Measurements of forward proton production with incident protons and charged pions on nuclear targets at the CERN Proton Synchrotron

DOE Office of Scientific and Technical Information (OSTI.GOV)

Apollonio, M.; Chimenti, P.; Giannini, G.

2010-10-15

Measurements of the double-differential proton production cross-section d{sup 2{sigma}}/dpd{Omega} in the range of momentum 0.5 GeV/c{<=}p<8.0 GeV/c and angle 0.05 rad{<=}{theta}<0.25 rad in collisions of charged pions and protons on beryllium, carbon, aluminium, copper, tin, tantalum, and lead are presented. The data were taken with the large acceptance HARP detector in the T9 beam line of the CERN Proton Synchrotron. Incident particles were identified by an elaborate system of beam detectors and impinged on a target of 5% of a nuclear interaction length. The tracking and identification of the produced particles was performed using the forward spectrometer of the HARPmore » experiment. Results are obtained for the double-differential cross-sections mainly at four incident beam momenta (3,5,8, and 12 GeV/c). Measurements are compared with predictions of the geant4 and mars Monte Carlo generators.« less

Rotationally resolved photoelectron spectroscopy of n-H/sub 2/, p-H/sub 2/, HD, and D/sub 2/

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pollard, J.E.; Trevor, D.J.; Reutt, J.E.

1982-07-01

The 584 A photoelectron spectra of n-H/sub 2/, p-H/sub 2/, HD, and D/sub 2/ were recorded at a resolution of 11 meV FWHM using a supersonic molecular beam source. Spectra were taken at several stagnation temperatures and pressures in order to vary the rotational population distribution in the beam with a corresponding variation in the relative intensities of the rotational transitions. Many of the Q-branch components were resolved for the first time. ..delta..G(v+1/2) and B/sub v/ values were measured for all observed vibrational states of H/sup +//sub 2/, HD/sup +/, and D/sup +//sub 2/ and were used to determined themore » ionic vibrational and rotational constants: ..omega../sub e/, ..omega../sub e/x/sub e/, ..omega../sub e/y/sub e/, ..omega../sub e/z/sub e/, B/sub e/, and ..cap alpha../sub e/. The results represent a substantial improvement over previous experimental determinations and were found to be consistent with the available theoretical rotation-vibration energy levels. The measurement of the intensity distribution of photoelectrons as a function of vibrational states yielded photoionization cross sections which were in good agreement with the theoretical values calculated by O'Niel and Reinhardt.« less

Extratropical signature of the quasi-biennial oscillation

NASA Technical Reports Server (NTRS)

Ruzmaikin, Alexander; Feynman, Joan; Jiang, Xun; Yung, Yuk L.

2005-01-01

Using the assimilated data from the National Centers for Environmental Prediction (NCEP) reanalysis, we show that the extratropical signature of the tropical quasi-biennial oscillation (QBO) is seen mostly in the North Annular Mode (NAM) of atmospheric variability. To understand the extratropical manifestation of the QBO, we discuss two effects that have been suggested earlier: (1) The extratropical circulation is driven by the QBO modulation of the planetary wave flux, and (2) the extratropical circulation is driven by the QBO-induced meridional circulation. We found that the first effect is seen in wave 1 in the beginning of winter and in wave 2 in the end of winter. The QBO-induced circulation affects midlatitude regions over the entire winter. To investigate the QBONAM coupling, we use an equation that relates the stream function of the meridional circulation and the polar cap averaged temperature, which is a proxy for the NAM index. In addition to the annual (omega)a and the QBO frequency (omega)Q the spectrum of its solutions indicates the satellite frequencies at (omega)a +/- (o.

Untranslated regions of diverse plant viral RNAs vary greatly in translation enhancement efficiency

PubMed Central

2012-01-01

Background Whole plants or plant cell cultures can serve as low cost bioreactors to produce massive amounts of a specific protein for pharmacological or industrial use. To maximize protein expression, translation of mRNA must be optimized. Many plant viral RNAs harbor extremely efficient translation enhancers. However, few of these different translation elements have been compared side-by-side. Thus, it is unclear which are the most efficient translation enhancers. Here, we compare the effects of untranslated regions (UTRs) containing translation elements from six plant viruses on translation in wheat germ extract and in monocotyledenous and dicotyledenous plant cells. Results The highest expressing uncapped mRNAs contained viral UTRs harboring Barley yellow dwarf virus (BYDV)-like cap-independent translation elements (BTEs). The BYDV BTE conferred the most efficient translation of a luciferase reporter in wheat germ extract and oat protoplasts, while uncapped mRNA containing the BTE from Tobacco necrosis virus-D translated most efficiently in tobacco cells. Capped mRNA containing the Tobacco mosaic virus omega sequence was the most efficient mRNA in tobacco cells. UTRs from Satellite tobacco necrosis virus, Tomato bushy stunt virus, and Crucifer-infecting tobamovirus (crTMV) did not stimulate translation efficiently. mRNA with the crTMV 5′ UTR was unstable in tobacco protoplasts. Conclusions BTEs confer the highest levels of translation of uncapped mRNAs in vitro and in vivo, while the capped omega sequence is most efficient in tobacco cells. These results provide a basis for understanding mechanisms of translation enhancement, and for maximizing protein synthesis in cell-free systems, transgenic plants, or in viral expression vectors. PMID:22559081

Electromagnetic properties of thin-film transformer-coupled superconducting tunnel junctions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Finnegan, T.F.; Lacquaniti, V.; Vaglio, R.

1981-09-01

Multisection superconducting microstrip transformers with designed output impedances below 0.1 ..cap omega.. have been fabricated via precise photolithographic techniques to investigate the electromagnetic properties of Nb-Nb oxide-Pb tunnel junctions. The low-impedance transformer sections incorporate a rf sputtered thin-film Ta-oxide dielectric, and the reproducible external coupling achievable with this type of geometry makes possible the systematic investigation of electromagnetic device parameters as a function of tunneling oxide thickness.

Forward production of charged pions with incident protons on nuclear targets at the CERN Proton Synchrotron

DOE Office of Scientific and Technical Information (OSTI.GOV)

Apollonio, M.; Chimenti, P.; Giannini, G.

2009-09-15

Measurements of the double-differential {pi}{sup {+-}} production cross section in the range of momentum 0.5{<=}p{<=}8.0 GeV/c and angle 0.025{<=}{theta}{<=}0.25 rad in collisions of protons on beryllium, carbon, nitrogen, oxygen, aluminum, copper, tin, tantalum, and lead are presented. The data were taken with the large-acceptance HAdRon Production (HARP) detector in the T9 beamline of the CERN Proton Synchrotron. Incident particles were identified by an elaborate system of beam detectors. Thin targets of 5% of a nuclear interaction length were used. The tracking and identification of the produced particles were performed using the forward system of the HARP experiment. Results are obtainedmore » for the double-differential cross sections d{sup 2}{sigma}/dp d{omega} mainly at four incident proton beam momenta (3, 5, 8, and 12 GeV/c). Measurements are compared with the GEANT4 and MARS Monte Carlo generators. A global parametrization is provided as an approximation of all the collected datasets, which can serve as a tool for quick yield estimates.« less

Driving of Dramatic Geomagnetic Activity by Enhancement of Meso-Scale Polar-cap Flows

NASA Astrophysics Data System (ADS)

Lyons, L. R.; Gallardo-Lacourt, B.; Zou, Y.; Nishimura, Y.; Anderson, P. C.; Angelopoulos, V.; Ruohoniemi, J. M.; Mitchell, E. J.; Paxton, L. J.; Nishitani, N.

2017-12-01

Recent studies have shown that mesoscale flows are common within the polar cap ionosphere. They often cross the magnetic separatrix, and become are critical to the driving of geomagnetic activity. They lead, for example, to plasma sheet flow bursts, auroral poleward boundary intensifications, auroral streamers, substorms, auroral omega bands, and poleward motion of the polar cap boundary from reconnection. We have found large enhancements of these meso-scale ionospheric polar cap flows heading towards the nightside separatrix. These enhancements are common immediately after the impact of CME shocks under southward IMF, but can also occur in other situations, including without substantial change in the solar wind or IMF. These meso-scale flow enhancements, which must extent outward along magnetospheric field lines from the ionosphere, are seen to drive an almost immediate strong auroral, ionospheric and field-aligned current, and reconnection activity. The resulting activity is particularly dramatic during the initiation of CME storms, but may reflect a more generally occurring phenomenon of mesoscale flow enhancements leading to similar oval responses without a shock impact, including during and following the expansion phase some substorms. If this phenomenon is indeed common, it could lead to possibly fundamental questions, such as when do polar cap convection enhancements lead to a substorm growth phase versus leading directly to strong poleward expansion of, and strong activity within, the auroral oval field line region? Another critical question would be what leads to and causes the enhancements in meso-scale polar cap flows?

Observations of the north polar water ice annulus on Mars using THEMIS and TES

USGS Publications Warehouse

Wagstaff, K.L.; Titus, T.N.; Ivanov, A.B.; Castano, R.; Bandfield, J.L.

2008-01-01

The Martian seasonal CO2 ice caps advance and retreat each year. In the spring, as the CO2 cap gradually retreats, it leaves behind an extensive defrosting zone from the solid CO2 cap to the location where all CO2 frost has sublimated. We have been studying this phenomenon in the north polar region using data from the THermal EMission Imaging System (THEMIS), a visible and infra-red (IR) camera on the Mars Odyssey spacecraft, and the Thermal Emission Spectrometer (TES) on Mars Global Surveyor. Recently, we discovered that some THEMIS images of the CO2 defrosting zone contain evidence for a distinct defrosting phenomenon: some areas just south of the CO2 cap edge are too bright in visible wavelengths to be defrosted terrain, but too warm in the IR to be CO2 ice. We hypothesize that we are seeing evidence for a seasonal annulus of water ice (frost) that recedes with the seasonal CO2 cap, as predicted by previous workers. In this paper, we describe our observations with THEMIS and compare them to simultaneous observations by TES and OMEGA. All three instruments find that this phenomenon is distinct from the CO2 cap and most likely composed of water ice. We also find strong evidence that the annulus widens as it recedes. Finally, we show that this annulus can be detected in the raw THEMIS data as it is collected, enabling future long-term onboard monitoring. ?? 2007.

Ligand-independent activation of EphA2 by arachidonic acid induces metastasis-like behaviour in prostate cancer cells

PubMed Central

Tawadros, T; Brown, M D; Hart, C A; Clarke, N W

2012-01-01

Background: High intake of omega-6 polyunsaturated fatty acids (PUFA) has been associated with clinical progression in prostate cancer (CaP). This study investigates the signalling mechanism by which the omega-6 PUFA arachidonic acid (AA) induces prostatic cellular migration to bone marrow stroma. Methods: Western blot analysis of the PC-3, PC3-GFP, DU 145 and LNCaP cells or their lipid raft (LR) components post AA stimulation was conducted in association with assays for adhesion and invasion through the bone marrow endothelial monolayers. Results: Arachidonic acid increased transendothelial migration of PC3-GFP cells (adhesion 37%±0.08, P=0.0124; transmigration 270%±0.145, P=0.0008). Akt, Src and focal adhesion kinase (FAK) pathways were induced by AA and integrally involved in transendothelial migration. LR were critical in AA uptake and induced Akt activity. Ephrin receptor A2 (EphA2), localised in LR, is expressed in DU 145 and PC-3 cells. Arachidonic acid induced a rapid increase of EphA2 Akt-dependent/ligand-independent activation, while knockdown of the EphrinA1 ligand decreased AA induced transendothelial migration, with an associated decrease in Src and FAK activity. Arachidonic acid activated Akt in EphA2− LNCaP cells but failed to induce BMEC transendothelial invasion. Conclusion: Arachidonic acid induced stimulation of EphA2 in vitro is associated fundamentally with CaP epithelial migration across the endothelial barrier. PMID:23037715

Series array of highly hysteretic Josephson junctions coupled to a microstrip resonator

DOE Office of Scientific and Technical Information (OSTI.GOV)

Costabile, G.; Andreone, D.; Lacquaniti, V.

1985-07-15

We have tested a new device based on a 12 junction array coupled to a resonator. We have explored the feasibility of the phase lock for all the junctions at the same biasing current, which yields voltage quantization across each junction, eliminating the need to individually bias the junctions. The whole rf structure has been realized by stripline technology. The resonator is fed by a 50-..cap omega.. line and is decoupled from the dc circuit by elliptical low-pass filters inserted in the bias leads.

Risk factors for exudative age-related macular degeneration in a large French case-control study.

PubMed

Zerbib, Jennyfer; Delcourt, Cécile; Puche, Nathalie; Querques, Giuseppe; Cohen, Salomon Yves; Sahel, José; Korobelnik, Jean-François; Le Goff, Mélanie; Souied, Eric H

2014-06-01

The purpose of the CAP (Creteil AMD PHRC-funded) Study was to analyze risk factors of exudative age-related macular degeneration (AMD) in a large French case-control population. One thousand and twenty-four patients with exudative AMD and 275 controls were recruited. Information about lifestyle, medical history, and dietary intake were collected. Associations of risk factors were estimated using logistic regression. After multivariate adjustment, CFH Y402H and ARMS2 A69S polymorphisms were associated with very high risk for exudative AMD (OR = 6.21 and OR = 11.7, respectively, p < 0.0001). Risk for exudative AMD was increased in current smokers (OR = 3.79, p = 0.0003) and former smokers having quitted since less than 20 years ago (OR = 2.30, p = 0.002), but not in former smokers having quitted since 20 years or more ago (OR = 0.81, p = 0.43). Heavy smokers (at least 25 pack-years) were particularly at risk (OR = 3.61, p < 0.0001). Use of cooking oils rich in omega 3 fatty acids was significantly associated with a reduced risk of exudative AMD (OR = 0.55, 95 % CI: 0.36-0.84, p = 0.006), as well as a high consumption of fruits (OR = 0.60, 95 % CI: 0.37-0.98, p = 0.04), but not the consumption of fish, vegetables or oils rich in omega 6. High waist circumference was associated with increased risk for exudative AMD (OR = 2.53, p < 0.0001), but not hypercholesterolemia, hypertension, or body mass index. The CAP Study confirms major genetic risk factors for exudative AMD. It further documents the high risk in heavy smokers and the long persistence of risk after smoking cessation, and the associations with waist circumference and fruit consumption. Furthermore, we observed an inverse correlation between AMD and cooking oils harboring a beneficial omega-3 fatty acid profile.

Simulation of electrostatic turbulence in the plasma sheet boundary layer with electron currents and bean-shaped ion beams

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nishikawa, K.; Frank, L.A.; Huang, C.Y.

Plasma data from ISEE 1 show the presence of electron currents as well as energetic ion beams in the plasma sheet boundary layer. Broadband electrostatic noise and low-frequency electromagnetic bursts are detected in the plasma sheet boundary layer, especially in the presence of strong ion flows, currents, and steep spacial gradients in the fluxes of few-keV electrons and ions. Particle simulations have been performed to investigate electrostatic turbulence driven by a cold electron beam and/or ion beams with a bean-shaped velocity distribution. The simulation results show that the counterstreaming ion beams as well as the counterstreaming of the cold electronmore » beam and the ion beam excite ion acoustic waves with the Doppler-shifted real frequency ..omega..approx. = +- k/sub parallel/(c/sub s/-V/sub i//sub //sub parallel/). However, the effect of the bean-shaped ion velocity distributions reduces the growth rates of ion acoustic instability. The simulation results also show that the slowing down of the ion beam is larger at the larger perpendicular velocity. The wave spectra of the electric fields at some points for simulations show turbulence generated by growing waves. The frequency of these spectra ranges from ..cap omega../sub i/ to ..omega../sub p//sub e/, which is in qualitative agreement with the satellite data. copyright American Geophysical Union 1988« less

Measurement of meson resonance production in $$\\pi ^- + C$$ interactions at SPS energies: The NA61/SHINE Collaboration

DOE Office of Scientific and Technical Information (OSTI.GOV)

Aduszkiewicz, A.; Ali, Y.; Andronov, E. V.

Here, we present measurements ofmore » $$\\rho^0$$, $$\\omega$$ and K$$^{*0}$$ spectra in $$\\pi^{-} + $$C production interactions at 158 GeV/c and $$\\rho^0$$ spectra at 350 GeV/c using the NA61/SHINE spectrometer at the CERN SPS. Spectra are presented as a function of the Feynman's variable $$x_\\text{F}$$ in the range $$0 < x_\\text{F} < 1$$ and $$0 < x_\\text{F} < 0.5$$ for 158 GeV/c and 350 GeV/c respectively. Furthermore, we show comparisons with previous measurements and predictions of several hadronic interaction models. Our measurements are essential for a better understanding of hadronic shower development and for improving the modeling of cosmic ray air showers.« less

Measurement of meson resonance production in $$\\pi ^- + C$$ interactions at SPS energies: The NA61/SHINE Collaboration

DOE PAGES

Aduszkiewicz, A.; Ali, Y.; Andronov, E. V.; ...

2017-09-20

Here, we present measurements ofmore » $$\\rho^0$$, $$\\omega$$ and K$$^{*0}$$ spectra in $$\\pi^{-} + $$C production interactions at 158 GeV/c and $$\\rho^0$$ spectra at 350 GeV/c using the NA61/SHINE spectrometer at the CERN SPS. Spectra are presented as a function of the Feynman's variable $$x_\\text{F}$$ in the range $$0 < x_\\text{F} < 1$$ and $$0 < x_\\text{F} < 0.5$$ for 158 GeV/c and 350 GeV/c respectively. Furthermore, we show comparisons with previous measurements and predictions of several hadronic interaction models. Our measurements are essential for a better understanding of hadronic shower development and for improving the modeling of cosmic ray air showers.« less

Iron mineralogy of the surface of Mars from the 1 μm band spectral properties

NASA Astrophysics Data System (ADS)

Carrozzo, F. G.; Altieri, F.; Bellucci, G.; Poulet, F.; D'Aversa, E.; Bibring, J.-P.

2012-10-01

We study the 1 μm absorption from OMEGA/MEX spectra to map Martian iron mineralogy at a global scale. This band is covered on the left by the VNIR (visible and near infrared) OMEGA channel and on the right by the SWIR (short wavelengths infrared) one. We first perform a systematic spatial coregistration of the two channels after an improvement of the VNIR radiometric calibration. The update of the VNIR Instrumental Transfer Function (ITF) and the internal stray-light estimation is based on the spectra of the Phobos red units and of the water ice north polar cap of Mars, which have been fitted according to an iterative process. The level of the signal in the blue wavelength range, previously systematically overestimated due to a stray-light residual and the general shape of the spectrum for λ > 0.7 μm are improved . Global maps of the 1 μm signature have been derived from 9 new spectral indices. The largest values of the 1 μm band integral are found in Noachian terrains and in the dunes around the north polar cap. In the south polar region, an area centered at ˜155°W and ˜83°S is mapped as a distinctive spectral unit, dominated by pyroxene. The northern lowlands of Mars together with other dark terrains located in the northern hemisphere show very low values of some spectral indices due to the negative spectral slope in the NIR. This behavior is consistent with the presence of weathered basalts with a possible glassy or amorphous component. Among the hydrated terrains, the only ones that can be isolated by studying the 1 μm band are those located in Terra Meridiani, Aram Chaos and Capri Chasma, enriched in sulfate and hematite. On the other hand, the sulfates of the dark dunes surrounding the northern polar cap and the phyllosilicates of the bright hydrated deposits of Mawrth Vallis cannot be isolated combining the parameters used in this study. This suggests that their distinctive mineralogy does not affect the 1 μm band, remaining similar to the global Martian average shape.

Piezo electric polaron and polaron pinning in n-CdS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nagasaka, K.

1976-05-01

The cyclotron resonance of the piezoelectric polaron in n-CdS has been investigated using far infrared spectroscopy at magnetic fields to 90 kOe. Both lamellar grating and Michelson Fourier transform spectrometers were used with a 0.3/sup 0/K Ge bolometer to study the photon energy region from 10 cm/sup -1/ to 60 cm/sup -1/. The theory of Miyake predicts that the frequency of the polaron's cyclotron resonance is shifted from the bare hand electron resonance frequency according to the expression: ..delta omega../sup p//sub c// ..cap omega../sub c/ varies as H/sup -1/ T/sup /sup 2///sup 3//. The magnetic field dependence of the presentmore » cyclotron resonance confirms this expression; the cyclotron mass isiezoelectric polaron effects. The bare band mass in n-CdS has also been determined by taking into account the Froehlich polaron interaction in addition to the piezoelectric polaron effects. For H parallel to the c-axis this cyclotron mass is 0.155 +- 0.005 m. The polaron pinning due to the 43 cm/sup -1/ optically inactive phonon has been observed.« less

Global maps of anhydrous minerals at the surface of Mars from OMEGA/MEx

NASA Astrophysics Data System (ADS)

Ody, A.; Poulet, F.; Langevin, Y.; Bibring, J.-P.; Bellucci, G.; Altieri, F.; Gondet, B.; Vincendon, M.; Carter, J.; Manaud, N.

2012-09-01

We here reassess the global distribution of several key mineral species using the entire OMEGA/Mars Express VIS-NIR imaging spectrometer data set, acquired from orbit insertion in January 2004 to August 2010. Thirty-two pixels per degree global maps of ferric oxides, pyroxenes and olivines have been derived. A significant filtering process was applied in order to exclude data acquired with unfavorable observation geometries or partial surface coverage with water and CO2 frosts. Because of strong atmospheric variations over the 3.6 Martian years of observations primarily due to the interannual variability of the aerosol opacity, a new filter based on the atmospheric dust opacity calibrated by the Mars Exploration Rovers measurements has also been implemented. The Fe3+ absorption features are present everywhere on the surface, with a variety of intensities indicating distinct formation processes. The pyroxene-bearing regions are localized in low albedo regions, while the bright regions are spectrally comparable to anhydrous nanophase ferric oxides. The expanded data set increases by a factor of about 2, the number of olivine detections reported in previous OMEGA-based studies. Olivine is mainly detected in three types of areas over the Martian surface: discontinuous patches on the terraces of the three main basins; smooth inter-crater plains and smooth crater floors throughout the southern highlands; and crater sand dunes, crater ejectas and extended bedrock exposures in the northern plains. Olivine is also detected in the low albedo pyroxene-bearing dunes surrounding the northern polar cap.

Pair-Starved Pulsar Magnetospheres

NASA Technical Reports Server (NTRS)

Muslimov, Alex G.; Harding, Alice K.

2009-01-01

We propose a simple analytic model for the innermost (within the light cylinder of canonical radius, approx. c/Omega) structure of open-magnetic-field lines of a rotating neutron star (NS) with relativistic outflow of charged particles (electrons/positrons) and arbitrary angle between the NS spin and magnetic axes. We present the self-consistent solution of Maxwell's equations for the magnetic field and electric current in the pair-starved regime where the density of electron-positron plasma generated above the pulsar polar cap is not sufficient to completely screen the accelerating electric field and thus establish thee E . B = 0 condition above the pair-formation front up to the very high altitudes within the light cylinder. The proposed mode1 may provide a theoretical framework for developing the refined model of the global pair-starved pulsar magnetosphere.

Quasi-stellar objects in the intergalactic medium: Source for the cosmic X-ray background

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sherman, R.D.

1980-06-15

QSOs are regarded as sources of both electromagnetic radiation and ejected matter that heat and ionize a dense intergalactic medium (IGM). Using current estimates of QSO luminosity, number density, evolution, and spectral index, we study three viable models: the diffuse cosmic X-ray background is (1) due entirely to thermal Bremsstrahlung of the IGM, (2) completely supplied by QSO X-radiation, (3) or a combination of both. The upper limits on an IGM fractional density with respect to closure are ..cap omega..=0.26, 0.24, and 0.21 for pure collisional, photo/collisional mixture, and pure photoionization, respectively. These calculations give emission spectra, Compton distortion ofmore » the cosmic microwave background, and optical depths to distant OSOs for comparison with relevant data.« less

Assessment of essential fatty acid and omega3-fatty acid status by measurement of erythrocyte 20:3omega9 (Mead acid), 22:5omega6/20:4omega6 and 22:5omega6/22:6omega3.

PubMed

Fokkema, M R; Smit, E N; Martini, I A; Woltil, H A; Boersma, E R; Muskiet, F A J

2002-11-01

Early suspicion of essential fatty acid deficiency (EFAD) or omega3-deficiency may rather focus on polyunsaturated fatty acid (PUFA) or long-chain PUFA (LCP) analyses than clinical symptoms. We determined cut-off values for biochemical EFAD, omega3-and omega3/22:6omega3 [docosahexaenoic acid (DHA)]-deficiency by measurement of erythrocyte 20:3omega9 (Mead acid), 22:5omega6/20:4omega6 and 22:5omega6/22:6omega3, respectively. Cut-off values, based on 97.5 percentiles, derived from an apparently healthy omnivorous group (six Dominica breast-fed newborns, 32 breast-fed and 27 formula+LCP-fed Dutch low-birth-weight infants, 31 Jerusalem infants, 33 Dutch 3.5-year-old infants, 69 omnivorous Dutch adults and seven Dominica mothers) and an apparently healthy group with low dietary LCP intake (81 formula-fed Dutch low-birth-weight infants, 12 Dutch vegans). Cut-off values were evaluated by their application in an EFAD suspected group of 108, mostly malnourished, Pakistani children, three pediatric patients with chronic fat-malabsorption (abetal-ipoproteinemia, congenital jejunal and biliary atresia) and one patient with a peroxisomal beta-oxidation disorder. Erythrocyte 20:3omega9, 22:5omega6/20:4omega6 and 22:5omega6/22:6omega3 proved age-dependent up to 0.2 years. Cut-off values for ages above 0.2 years were: 0.46mol% 20:3omega9 for EFAD, 0.068mol/mol 22:5omega6/20:4omega6 for omega3-deficiency, 0.22mol/mol 22:5omega6/22:6omega3 for omega3/DHA-marginality and 0.48mol/mol 22:5omega6/22:6omega3 for omega3/DHA-deficiency. Use of RBC 20:3omega9 and 22:5omega6/20:4omega6 cut-off values identified 20.4% of the Pakistani subjects as EFAD+omega3-deficient, 12.9% as EFAD+omega3-sufficient, 38.9% as EFA-sufficient+omega3-deficient and 27.8% as EFA-sufficient+omega3-sufficient. The patient with the peroxisomal disorder was classified as EFA-sufficient, omega3-sufficient (based on RBC 22:5omega6/20:4omega6) and omega3/DHA-deficient (based on RBC 22:5omega6/22:6omega3). The three other pediatric patients were classified as EFAD, omega3-deficient and omega3/DHA-deficient. Use of the combination of the present cut-off values for EFA, omega3 and omega3/DHA status assessment, as based on 97.5 percentiles, may serve for PUFA supplement intervention until better concepts have emerged.

Spatial profile reconstruction of individual componentsof the nonlinear susceptibility tensors {chi}-circumflex {sup (3)}(z, {omega}', {omega}' -{omega}, {omega}) and {chi}-circumflex {sup (3)}(z, 2{omega}{+-}{omega}', {+-}{omega}', {omega}, {omega}) of a one-dimensionally inhomogeneous medium

DOE Office of Scientific and Technical Information (OSTI.GOV)

Golubkov, A A; Makarov, Vladimir A

We have proved for the first time and proposed an algorithm of unique spatial profile reconstruction of the components {chi}-circumflex {sup (3)}{sub yyyy} of complex tensors {chi}-circumflex {sup (3)}(z, {omega}', {omega}', -{omega}, {omega}) and {chi}-circumflex {sup (3)}(z, 2{omega}{+-}{omega}', {+-}{omega}', {omega}, {omega}), describing four-photon interaction of light waves in a one-dimensionally inhomogeneous plate, whose medium has a symmetry plane m{sub y} that is perpendicular to its surface. For the media with an additional symmetry axis 2{sub z}, 4{sub z}, 6{sub z} or {infinity}{sub z} that is perpendicular to the plate surface, the proposed method can be used to reconstruct about one-fifthmore » of all independent components of the above tensors. (nonlinear optical phenomena)« less

78 FR 53189 - Dorel Juvenile Group, Denial of Petition for Decision of Inconsequential Noncompliance

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-28

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Tunable infrared source employing Raman mixing

DOEpatents

Byer, Robert L.; Herbst, Richard L.

1980-01-01

A tunable source of infrared radiation is obtained by irradiating an assemblage of Raman active gaseous atoms or molecules with a high intensity pumping beam of coherent radiation at a pump frequency .omega..sub.p to stimulate the generation of Stokes wave energy at a Stokes frequency .omega..sub.s and to stimulate the Raman resonant mode at the Raman mode frequency .omega..sub.R within the irradiated assemblage where the pump frequency .omega..sub.p minus the Stokes frequency .omega..sub.s is equal to the Raman mode frequency .omega..sub.R. The stimulated assemblage is irradiated with a tunable source of coherent radiation at a frequency .omega..sub.i to generate the output infrared radiation of the frequency .omega..sub.0 which is related to the Raman mode frequency .omega..sub.R and the input wave .omega..sub.i by the relation .omega..sub.0 =.omega..sub.i .+-..omega..sub.R. In one embodiment the interaction between the pump wave energy .omega..sub.p and the tunable input wave energy .omega..sub.i is collinear and the ratio of the phase velocity mismatch factor .DELTA.k to the electric field exponential gain coefficient T is within the range of 0.1 to 5. In another embodiment the pump wave energy .omega..sub.p and the tunable input wave energy .omega..sub.i have velocity vectors k.sub.p and k.sub.i which cross at an angle to each other to compensate for phase velocity mismatches in the medium. In another embodiment, the Stokes wave energy .omega..sub.s is generated by pump energy .omega..sub.p in a first Raman cell and .omega..sub.s, .omega..sub.i and .omega..sub.p are combined in a second Raman mixing cell to produce the output at .omega..sub.i.

Understanding the branching ratios of {chi}{sub c1{yields}{phi}{phi}}, {omega}{omega}, {omega}{phi} observed at BES-III

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chen Dianyong; He Jun; Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000

In this work, we discuss the contribution of the mesonic loops to the decay rates of {chi}{sub c1{yields}{phi}{phi}}, {omega}{omega}, which are suppressed by the helicity selection rules and {chi}{sub c1{yields}{phi}{omega}}, which is a double-Okubo-Zweig-Iizuka forbidden process. We find that the mesonic loop effects naturally explain the clear signals of {chi}{sub c1{yields}{phi}{phi}}, {omega}{omega} decay modes observed by the BES Collaboration. Moreover, we investigate the effects of the {omega}-{phi} mixing, which may result in the order of magnitude of the branching ratio BR({chi}{sub c1{yields}{omega}{phi}}) being 10{sup -7}. Thus, we are waiting for the accurate measurements of the BR({chi}{sub c1{yields}{omega}{omega}}), BR({chi}{sub c1{yields}{phi}{phi}}), andmore » BR({chi}{sub c1{yields}{omega}{phi}}), which may be very helpful for testing the long-distant contribution and the {omega}-{phi} mixing in {chi}{sub c1{yields}{phi}{phi}}, {omega}{omega}, {omega}{phi} decays.« less

Cubic optical nonlinearity of free electrons in bulk gold.

PubMed

Zheludev, N I; Bennett, P J; Loh, H; Popov, S V; Shatwell, I R; Svirko, Y P; Gusev, V E; Kamalov, V F; Slobodchikov, E V

1995-06-15

A fast (Tau(response) <90 fs) free-electron spin-f lipping frequency-degenerate nonlinearity with a signif icant value of|chi((3))(xxyy)(omega,omega,omega,-omega)chi((3))(xxyy)(omega,omega,omega,-omega)|~10(-)(8)esu has been observed in bulk gold at 1260 nm by use of a new pump-probe polarization-sensitive technique.

High-yield entangled single photon source

DOE Office of Scientific and Technical Information (OSTI.GOV)

Soh, Daniel B. S.; Bisson, Scott E.

The various technologies presented herein relate to utilizing photons at respective idler and signal frequencies to facilitate generation of photons at a pump frequency. A strong pump field can be applied at the .omega..sub.i and the .omega..sub.s frequencies, with the generated idler and signal pulses being utilized to generate a photon pair at the .omega..sub.p frequency. Further, the idler pump power can be increased relative to the signal pump power such that the pump power P.sub.i>pump power P.sub.s. Such reversed operation (e.g., .omega..sub.i+.omega..sub.s.fwdarw..omega..sub.p1+.omega..sub.p2) can minimize and/or negate Raman scattering effects. By complying with an energy conservation requirement, the .omega..sub.i andmore » .omega..sub.s photons interacting with the material through the four-wave mixing process facilitates the entanglement of the .omega..sub.p1 and .omega..sub.p2 photons. The .omega..sub.i and .omega..sub.s photons can be respectively formed in different length waveguides with a delay utilized to facilitate common timing between the .omega..sub.i and .omega..sub.s photons.« less

An Increase in the Omega-6/Omega-3 Fatty Acid Ratio Increases the Risk for Obesity.

PubMed

Simopoulos, Artemis P

2016-03-02

In the past three decades, total fat and saturated fat intake as a percentage of total calories has continuously decreased in Western diets, while the intake of omega-6 fatty acid increased and the omega-3 fatty acid decreased, resulting in a large increase in the omega-6/omega-3 ratio from 1:1 during evolution to 20:1 today or even higher. This change in the composition of fatty acids parallels a significant increase in the prevalence of overweight and obesity. Experimental studies have suggested that omega-6 and omega-3 fatty acids elicit divergent effects on body fat gain through mechanisms of adipogenesis, browning of adipose tissue, lipid homeostasis, brain-gut-adipose tissue axis, and most importantly systemic inflammation. Prospective studies clearly show an increase in the risk of obesity as the level of omega-6 fatty acids and the omega-6/omega-3 ratio increase in red blood cell (RBC) membrane phospholipids, whereas high omega-3 RBC membrane phospholipids decrease the risk of obesity. Recent studies in humans show that in addition to absolute amounts of omega-6 and omega-3 fatty acid intake, the omega-6/omega-3 ratio plays an important role in increasing the development of obesity via both AA eicosanoid metabolites and hyperactivity of the cannabinoid system, which can be reversed with increased intake of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). A balanced omega-6/omega-3 ratio is important for health and in the prevention and management of obesity.

An Increase in the Omega-6/Omega-3 Fatty Acid Ratio Increases the Risk for Obesity

PubMed Central

Simopoulos, Artemis P.

2016-01-01

In the past three decades, total fat and saturated fat intake as a percentage of total calories has continuously decreased in Western diets, while the intake of omega-6 fatty acid increased and the omega-3 fatty acid decreased, resulting in a large increase in the omega-6/omega-3 ratio from 1:1 during evolution to 20:1 today or even higher. This change in the composition of fatty acids parallels a significant increase in the prevalence of overweight and obesity. Experimental studies have suggested that omega-6 and omega-3 fatty acids elicit divergent effects on body fat gain through mechanisms of adipogenesis, browning of adipose tissue, lipid homeostasis, brain-gut-adipose tissue axis, and most importantly systemic inflammation. Prospective studies clearly show an increase in the risk of obesity as the level of omega-6 fatty acids and the omega-6/omega-3 ratio increase in red blood cell (RBC) membrane phospholipids, whereas high omega-3 RBC membrane phospholipids decrease the risk of obesity. Recent studies in humans show that in addition to absolute amounts of omega-6 and omega-3 fatty acid intake, the omega-6/omega-3 ratio plays an important role in increasing the development of obesity via both AA eicosanoid metabolites and hyperactivity of the cannabinoid system, which can be reversed with increased intake of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). A balanced omega-6/omega-3 ratio is important for health and in the prevention and management of obesity. PMID:26950145

Meat-based functional foods for dietary equilibrium omega-6/omega-3.

PubMed

Reglero, Guillermo; Frial, Paloma; Cifuentes, Alejandro; García-Risco, Mónica R; Jaime, Laura; Marin, Francisco R; Palanca, Vicente; Ruiz-Rodríguez, Alejandro; Santoyo, Susana; Señoráns, Francisco J; Soler-Rivas, Cristina; Torres, Carlos; Ibañez, Elena

2008-10-01

Nutritionists encourage improving the diet by combining meat products with fish or other sea-related foods, in order to equilibrate the omega-6/omega-3 ratio. Strong scientific evidence supports the beneficial health effects of a balanced omega-6/omega-3 PUFA (poly unsaturated fatty acids) diets. In the present work, the scientific bases of new functional meat products with both a balanced omega-6/omega-3 ratio and a synergic combination of antioxidants are discussed. The aim is to contribute to the dietary equilibrium omega-6/omega-3 and to increase the antioxidant intake. Conventional meat products supplemented with a specific fatty acids and antioxidants combination led to functional foods with healthier nutritional parameters.

Influence of tensor interactions on masses and decay widths of dibaryons

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pang Hourong; Ping Jialun; Chen Lingzhi

The influence of gluon and Goldstone boson induced tensor interactions on the dibaryon masses and D-wave decay widths has been studied in the quark delocalization, color screening model. The effective S-D wave transition interactions induced by gluon and Goldstone boson exchanges decrease rapidly with increasing strangeness of the channel. The tensor contribution of K and {eta} mesons is negligible in this model. There is no six-quark state in the light flavor world studied so far that can become bound by means of these tensor interactions besides the deuteron. The partial D-wave decay widths of the IJ{sup p}=(1/2)2{sup +}N{omega} state tomore » spin 0 and 1 {lambda}{xi} final states are 12.0 and 21.9 keV, respectively. This is a very narrow dibaryon resonance that might be detectable in those production reactions with rich high strangeness particles through the reconstruction of the vertex mass of the decay product {lambda}{xi} by existing detectors at RHIC and COMPASS at CERN or at JHF in Japan and FAIR in Germany in the future.« less

Using Caenorhabditis elegans to Uncover Conserved Functions of Omega-3 and Omega-6 Fatty Acids

PubMed Central

Watts, Jennifer L.

2016-01-01

The nematode Caenorhabditis elegans is a powerful model organism to study functions of polyunsaturated fatty acids. The ability to alter fatty acid composition with genetic manipulation and dietary supplementation permits the dissection of the roles of omega-3 and omega-6 fatty acids in many biological process including reproduction, aging and neurobiology. Studies in C. elegans to date have mostly identified overlapping functions of 20-carbon omega-6 and omega-3 fatty acids in reproduction and in neurons, however, specific roles for either omega-3 or omega-6 fatty acids are beginning to emerge. Recent findings with importance to human health include the identification of a conserved Cox-independent prostaglandin synthesis pathway, critical functions for cytochrome P450 derivatives of polyunsaturated fatty acids, the requirements for omega-6 and omega-3 fatty acids in sensory neurons, and the importance of fatty acid desaturation for long lifespan. Furthermore, the ability of C. elegans to interconvert omega-6 to omega-3 fatty acids using the FAT-1 omega-3 desaturase has been exploited in mammalian studies and biotechnology approaches to generate mammals capable of exogenous generation of omega-3 fatty acids. PMID:26848697

Lion roars and nonoscillatory drift mirror waves in the magnetosheath

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tsurutani, B.T.; Smith, E.J.; Anderson, R.R.

1982-08-01

A complete set of ISEE plasma wave, plasma, and field data are used to identify the plasma instability responsible for the generation of extremely low frequency (ELF) electromagnetic lion roars. Lion roars detected close to the magnetopause are generated by the cyclotron instability of anisotropic (T/sup -//sub perpendicular//T/sup -//sub parallel/approx. =1.2) thermal electrons when the local plasma critical energy, E/sub M/ = B/sup 2//8..pi..N, falls to values (E/sub M/ approx.10--30 eV) close to or below the electron thermal energy, 25 eV, as a result of decreases in B. The lion roars are terminated by increases in the ambient magnetic fieldmore » magnitude and consequential increases in E/sub M/ to values greater than 100 eV. Because there are few resonant particles at these high energies, the growth rate decreases by 3 orders of magnitude and measurable growth ceases. The value of the absolute upper limit of the frequency of unstable waves predicted by theory, ..omega../sub max/ = A/sup -/..cap omega../sup -//(A/sup -/+1), is compared with observations. The predictions and observations are found to be in general, but not exact, agreement. Several possible explanations are explored. The quasi-periodic, approx.20-s magnetic and plasma oscillations which cause the variations in E/sub M/ and hence alternately drive the cyclotron waves unstable and then stable are also investigated.« less

Vector-valued Lizorkin-Triebel spaces and sharp trace theory for functions in Sobolev spaces with mixed \\pmb{L_p}-norm for parabolic problems

NASA Astrophysics Data System (ADS)

Weidemaier, P.

2005-06-01

The trace problem on the hypersurface y_n=0 is investigated for a function u=u(y,t) \\in L_q(0,T;W_{\\underline p}^{\\underline m}(\\mathbb R_+^n)) with \\partial_t u \\in L_q(0,T; L_{\\underline p}(\\mathbb R_+^n)), that is, Sobolev spaces with mixed Lebesgue norm L_{\\underline p,q}(\\mathbb R^n_+\\times(0,T))=L_q(0,T;L_{\\underline p}(\\mathbb R_+^n)) are considered; here \\underline p=(p_1,\\dots,p_n) is a vector and \\mathbb R^n_+=\\mathbb R^{n-1} \\times (0,\\infty). Such function spaces are useful in the context of parabolic equations. They allow, in particular, different exponents of summability in space and time. It is shown that the sharp regularity of the trace in the time variable is characterized by the Lizorkin-Triebel space F_{q,p_n}^{1-1/(p_nm_n)}(0,T;L_{\\widetilde{\\underline p}}(\\mathbb R^{n-1})), \\underline p=(\\widetilde{\\underline p},p_n). A similar result is established for first order spatial derivatives of u. These results allow one to determine the exact spaces for the data in the inhomogeneous Dirichlet and Neumann problems for parabolic equations of the second order if the solution is in the space L_q(0,T; W_p^2(\\Omega)) \\cap W_q^1(0,T;L_p(\\Omega)) with p \\le q.

Propagation of an ultrashort, intense laser pulse in a relativistic plasma

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ritchie, B.; Decker, C.D.

1997-12-31

A Maxwell-relativistic fluid model is developed for the propagation of an ultrashort, intense laser pulse through an underdense plasma. The separability of plasma and optical frequencies ({omega}{sub p} and {omega} respectively) for small {omega}{sub p}/{omega} is not assumed; thus the validity of multiple-scales theory (MST) can be tested. The theory is valid when {omega}{sub p}/{omega} is of order unity or for cases in which {omega}{sub p}/{omega} {much_lt} 1 but strongly relativistic motion causes higher-order plasma harmonics to be generated which overlap the region of the first-order laser harmonic, such that MST would not expected to be valid although its principalmore » validity criterion {omega}{sub p}/{omega} {much_lt} 1 holds.« less

[Plasma fatty acids profile and lipids in Tunisian male elite athletes].

PubMed

Omar, Souheil; Sethom, Mohamed M; Feki-Mhiri, Sondes; Hadj-Taeib, Sameh; Ben Ayed, Ikram; Feki, Moncef; Kaabachi, Naziha

2010-05-01

Growing interest is accorded to polyunsaturated fatty acids (PUFAs) omega3, which are considered beneficial for health. to investigate the effect of sports on plasma lipids and fatty acids (FAs), especially omega6 and omega3 PUFAs and the omega6/omega3 ratio. The study included 75 Tunisian male elite athletes, practicing team sport and 70 sedentary healthy men as controls. Plasma FAs profile was analyzed by gas chromatography. Comparison between groups was performed using a univariate GLM analysis, with adjustment on age, body mass and energy intake. Athletes showed lower triglycerides and saturated FAs (27.64% +/- 2.17% vs. 30.41% +/- 4.35%) and increased HDL cholesterol and monounsaturated FAs (21.19% +/- 2 44% vs. 19.12% +/- 3.03%). However, there was no significant difference in total PUFAs, omega6 and omega3 families and omega6/omega3 ratio (10.15% +/- 3.24% vs. 10.20% +/- 3.37%) between athletes and sedentary. Sport favorably modifies the profile of plasma FAs by increasing monounsaturated FAs at the expense of saturated FAs, but has no effect on total PUFAs, and omega6 and omega3 families. A diet rich in omega3 PUFAs would lower the omega6/omega3 ratio, in order to improve the health and probably the performance of athletes.

Generation of Z mode radiation by diffuse auroral electron precipitation

NASA Astrophysics Data System (ADS)

Dusenbery, P. B.; Lyons, L. R.

1985-03-01

The generation of Z mode waves by diffuse auroral electron precipitation is investigated assuming that a loss cone exists in the upgoing portion of the distribution due to electron interactions with the atmosphere. The waves are generated at frequencies above, but very near, the local electron cyclotron frequency omega(e) and at wave normal angles larger than 90 deg. In agreement with Hewitt et al. (1983), the group velocity is directed downward in regions where the ratio of the upper hybrid frequency omega(pe) to Omega(e) is less than 0.5, so that Z mode waves excited above a satellite propagate toward it and away from the upper hybrid resonance. Z mode waves are excited in a frequency band between Omega(e) and about 1.02 Omega(e), and with maximum growth rates of about 0.001 Omega(e). The amplification length is about 100 km, which allows Z mode waves to grow to the intensities observed by high-altitude satellites.

Generation of Z mode radiation by diffuse auroral electron precipitation

NASA Technical Reports Server (NTRS)

Dusenbery, P. B.; Lyons, L. R.

1985-01-01

The generation of Z mode waves by diffuse auroral electron precipitation is investigated assuming that a loss cone exists in the upgoing portion of the distribution due to electron interactions with the atmosphere. The waves are generated at frequencies above, but very near, the local electron cyclotron frequency omega(e) and at wave normal angles larger than 90 deg. In agreement with Hewitt et al. (1983), the group velocity is directed downward in regions where the ratio of the upper hybrid frequency omega(pe) to Omega(e) is less than 0.5, so that Z mode waves excited above a satellite propagate toward it and away from the upper hybrid resonance. Z mode waves are excited in a frequency band between Omega(e) and about 1.02 Omega(e), and with maximum growth rates of about 0.001 Omega(e). The amplification length is about 100 km, which allows Z mode waves to grow to the intensities observed by high-altitude satellites.

Efficacy and Safety of Omega-3/6 Fatty Acids, Methylphenidate, and a Combined Treatment in Children With ADHD.

PubMed

Barragán, Eduardo; Breuer, Dieter; Döpfner, Manfred

2017-03-01

To compare efficacy of Omega-3/6 fatty acids (Equazen eye q™) with methylphenidate (MPH) and combined MPH + Omega-3/6 in children with ADHD. Participants ( N = 90) were randomized to Omega-3/6, long-acting MPH, or combination for 12 months. ADHD symptoms were assessed using the ADHD Rating Scale and Clinical Global Impressions-Severity (CGI-S) scale. ADHD symptoms decreased in all treatment arms. Although significant differences favoring Omega + MPH over Omega-3/6 alone were found for ADHD Total and Hyperactivity-Impulsivity subscales, results on the Inattention subscale were similar. CGI-S scores decreased slowly and consistently with Omega-3/6, compared with a rapid decrease and subsequent slight increase in the MPH-containing arms. Adverse events were numerically less frequent with Omega-3/6 or MPH + Omega-3/6 than MPH alone. The tested combination of Omega-3/6 fatty acids had similar effects to MPH, whereas the MPH + Omega combination appeared to have some tolerability benefits over MPH.

Diet-induced changes in n-3- and n-6-derived endocannabinoids and reductions in headache pain and psychological distress.

PubMed

Ramsden, Christopher E; Zamora, Daisy; Makriyannis, Alexandros; Wood, JodiAnne T; Mann, J Douglas; Faurot, Keturah R; MacIntosh, Beth A; Majchrzak-Hong, Sharon F; Gross, Jacklyn R; Courville, Amber B; Davis, John M; Hibbeln, Joseph R

2015-08-01

Omega-3 and omega-6 fatty acids are biosynthetic precursors of endocannabinoids with antinociceptive, anxiolytic, and neurogenic properties. We recently reported that targeted dietary manipulation-increasing omega-3 fatty acids while reducing omega-6 linoleic acid (the H3-L6 intervention)-reduced headache pain and psychological distress among chronic headache patients. It is not yet known whether these clinical improvements were due to changes in endocannabinoids and related mediators derived from omega-3 and omega-6 fatty acids. We therefore used data from this trial (N = 55) to investigate 1) whether the H3-L6 intervention altered omega-3- and omega-6-derived endocannabinoids in plasma and 2) whether diet-induced changes in these bioactive lipids were associated with clinical improvements. The H3-L6 intervention significantly increased the omega-3 docosahexaenoic acid derivatives 2-docosahexaenoylglycerol (+65%, P < .001) and docosahexaenoylethanolamine (+99%, P < .001) and reduced the omega-6 arachidonic acid derivative 2-arachidonoylglycerol (-25%, P = .001). Diet-induced changes in these endocannabinoid derivatives of omega-3 docosahexaenoic acid, but not omega-6 arachidonic acid, correlated with reductions in physical pain and psychological distress. These findings demonstrate that targeted dietary manipulation can alter endocannabinoids derived from omega-3 and omega-6 fatty acids in humans and suggest that 2-docosahexaenoylglycerol and docosahexaenoylethanolamine could have physical and/or psychological pain modulating properties. ClinicalTrials.gov (NCT01157208) PERSPECTIVE: This article demonstrates that targeted dietary manipulation can alter endocannabinoids derived from omega-3 and omega-6 fatty acids and that these changes are related to reductions in headache pain and psychological distress. These findings suggest that dietary interventions could provide an effective, complementary approach for managing chronic pain and related conditions. Published by Elsevier Inc.

A host-microbiome interaction mediates the opposing effects of omega-6 and omega-3 fatty acids on metabolic endotoxemia

PubMed Central

Kaliannan, Kanakaraju; Wang, Bin; Li, Xiang-Yong; Kim, Kui-Jin; Kang, Jing X.

2015-01-01

Metabolic endotoxemia, commonly derived from gut dysbiosis, is a primary cause of chronic low grade inflammation that underlies many chronic diseases. Here we show that mice fed a diet high in omega-6 fatty acids exhibit higher levels of metabolic endotoxemia and systemic low-grade inflammation, while transgenic conversion of tissue omega-6 to omega-3 fatty acids dramatically reduces endotoxemic and inflammatory status. These opposing effects of tissue omega-6 and omega-3 fatty acids can be eliminated by antibiotic treatment and animal co-housing, suggesting the involvement of the gut microbiota. Analysis of gut microbiota and fecal transfer revealed that elevated tissue omega-3 fatty acids enhance intestinal production and secretion of intestinal alkaline phosphatase (IAP), which induces changes in the gut bacteria composition resulting in decreased lipopolysaccharide production and gut permeability, and ultimately, reduced metabolic endotoxemia and inflammation. Our findings uncover an interaction between host tissue fatty acid composition and gut microbiota as a novel mechanism for the anti-inflammatory effect of omega-3 fatty acids. Given the excess of omega-6 and deficiency of omega-3 in the modern Western diet, the differential effects of tissue omega-6 and omega-3 fatty acids on gut microbiota and metabolic endotoxemia provide insight into the etiology and management of today’s health epidemics. PMID:26062993

A host-microbiome interaction mediates the opposing effects of omega-6 and omega-3 fatty acids on metabolic endotoxemia.

PubMed

Kaliannan, Kanakaraju; Wang, Bin; Li, Xiang-Yong; Kim, Kui-Jin; Kang, Jing X

2015-06-11

Metabolic endotoxemia, commonly derived from gut dysbiosis, is a primary cause of chronic low grade inflammation that underlies many chronic diseases. Here we show that mice fed a diet high in omega-6 fatty acids exhibit higher levels of metabolic endotoxemia and systemic low-grade inflammation, while transgenic conversion of tissue omega-6 to omega-3 fatty acids dramatically reduces endotoxemic and inflammatory status. These opposing effects of tissue omega-6 and omega-3 fatty acids can be eliminated by antibiotic treatment and animal co-housing, suggesting the involvement of the gut microbiota. Analysis of gut microbiota and fecal transfer revealed that elevated tissue omega-3 fatty acids enhance intestinal production and secretion of intestinal alkaline phosphatase (IAP), which induces changes in the gut bacteria composition resulting in decreased lipopolysaccharide production and gut permeability, and ultimately, reduced metabolic endotoxemia and inflammation. Our findings uncover an interaction between host tissue fatty acid composition and gut microbiota as a novel mechanism for the anti-inflammatory effect of omega-3 fatty acids. Given the excess of omega-6 and deficiency of omega-3 in the modern Western diet, the differential effects of tissue omega-6 and omega-3 fatty acids on gut microbiota and metabolic endotoxemia provide insight into the etiology and management of today's health epidemics.

Omega-3 polyunsaturated fatty acid and ursodeoxycholic acid have an additive effect in attenuating diet-induced nonalcoholic steatohepatitis in mice

PubMed Central

Kim, Ja Kyung; Lee, Kwan Sik; Lee, Dong Ki; Lee, Su Yeon; Chang, Hye Young; Choi, Junjeong; Lee, Jung Il

2014-01-01

Nonalcoholic steatohepatitis (NASH) can progress into liver cirrhosis; however, no definite treatment is available. Omega-3 polyunsaturated fatty acid (omega-3) has been reported to alleviate experimental NASH, although its beneficial effect was not evident when tested clinically. Thus, this study aimed to investigate the additive effect of omega-3 and ursodeoxycholic acid (UDCA) on diet-induced NASH in mice. C57BL/6 mice were given a high-fat diet (HFD) for 24 weeks, at which point the mice were divided into three groups and fed HFD alone, HFD with omega-3 or HFD with omega-3 in combination with UDCA for another 24 weeks. Feeding mice an HFD and administering omega-3 improved histologically assessed liver fibrosis, and UDCA in combination with omega-3 further attenuated this disease. The assessment of collagen α1(I) expression agreed with the histological evaluation. Omega-3 in combination with UDCA resulted in a significant attenuation of inflammation whereas administering omega-3 alone failed to improve histologically assessed liver inflammation. Quantitative analysis of tumor necrosis factor α showed an additive effect of omega-3 and UDCA on liver inflammation. HFD-induced hepatic triglyceride accumulation was attenuated by omega-3 and adding UDCA accentuated this effect. In accordance with this result, the expression of sterol regulatory binding protein-1c decreased after omega-3 administration and adding UDCA further diminished SREBP-1c expression. The expression of inducible nitric oxide synthase (iNOS), which may reflect oxidative stress-induced tissue damage, was suppressed by omega-3 administration and adding UDCA further attenuated iNOS expression. These results demonstrated an additive effect of omega-3 and UDCA for alleviating fibrosis, inflammation and steatosis in diet-induced NASH. PMID:25523099

Omega-3 polyunsaturated fatty acid and ursodeoxycholic acid have an additive effect in attenuating diet-induced nonalcoholic steatohepatitis in mice.

PubMed

Kim, Ja Kyung; Lee, Kwan Sik; Lee, Dong Ki; Lee, Su Yeon; Chang, Hye Young; Choi, Junjeong; Lee, Jung Il

2014-12-19

Nonalcoholic steatohepatitis (NASH) can progress into liver cirrhosis; however, no definite treatment is available. Omega-3 polyunsaturated fatty acid (omega-3) has been reported to alleviate experimental NASH, although its beneficial effect was not evident when tested clinically. Thus, this study aimed to investigate the additive effect of omega-3 and ursodeoxycholic acid (UDCA) on diet-induced NASH in mice. C57BL/6 mice were given a high-fat diet (HFD) for 24 weeks, at which point the mice were divided into three groups and fed HFD alone, HFD with omega-3 or HFD with omega-3 in combination with UDCA for another 24 weeks. Feeding mice an HFD and administering omega-3 improved histologically assessed liver fibrosis, and UDCA in combination with omega-3 further attenuated this disease. The assessment of collagen α1(I) expression agreed with the histological evaluation. Omega-3 in combination with UDCA resulted in a significant attenuation of inflammation whereas administering omega-3 alone failed to improve histologically assessed liver inflammation. Quantitative analysis of tumor necrosis factor α showed an additive effect of omega-3 and UDCA on liver inflammation. HFD-induced hepatic triglyceride accumulation was attenuated by omega-3 and adding UDCA accentuated this effect. In accordance with this result, the expression of sterol regulatory binding protein-1c decreased after omega-3 administration and adding UDCA further diminished SREBP-1c expression. The expression of inducible nitric oxide synthase (iNOS), which may reflect oxidative stress-induced tissue damage, was suppressed by omega-3 administration and adding UDCA further attenuated iNOS expression. These results demonstrated an additive effect of omega-3 and UDCA for alleviating fibrosis, inflammation and steatosis in diet-induced NASH.

Omega-3 fats: Good for your heart

MedlinePlus

... arteries - omega-3s; Coronary artery disease - omega-3s; Heart disease - omega-3s ... Omega-3s are good for your heart and blood vessels in several ways. They reduce triglycerides , a type of fat in your blood. They reduce the risk of an ...

Omega-3 deficiency impairs honey bee learning

PubMed Central

Arien, Yael; Dag, Arnon; Zarchin, Shlomi; Masci, Tania

2015-01-01

Deficiency in essential omega-3 polyunsaturated fatty acids (PUFAs), particularly the long-chain form of docosahexaenoic acid (DHA), has been linked to health problems in mammals, including many mental disorders and reduced cognitive performance. Insects have very low long-chain PUFA concentrations, and the effect of omega-3 deficiency on cognition in insects has not been studied. We show a low omega-6:3 ratio of pollen collected by honey bee colonies in heterogenous landscapes and in many hand-collected pollens that we analyzed. We identified Eucalyptus as an important bee-forage plant particularly poor in omega-3 and high in the omega-6:3 ratio. We tested the effect of dietary omega-3 deficiency on olfactory and tactile associative learning of the economically highly valued honey bee. Bees fed either of two omega-3–poor diets, or Eucalyptus pollen, showed greatly reduced learning abilities in conditioned proboscis-extension assays compared with those fed omega-3–rich diets, or omega-3–rich pollen mixture. The effect on performance was not due to reduced sucrose sensitivity. Omega-3 deficiency also led to smaller hypopharyngeal glands. Bee brains contained high omega-3 concentrations, which were only slightly affected by diet, suggesting additional peripheral effects on learning. The shift from a low to high omega-6:3 ratio in the Western human diet is deemed a primary cause of many diseases and reduced mental health. A similar shift seems to be occurring in bee forage, possibly an important factor in colony declines. Our study shows the detrimental effect on cognitive performance of omega-3 deficiency in a nonmammal. PMID:26644556

The Rosseland Mean Opacity in Dense Plasmas

NASA Astrophysics Data System (ADS)

van Horn, H. M.

1992-05-01

In post-main-sequence phases of stellar evolution, densities in the interiors of stars become large enough so that hbar omega_p /kT>1, where omega_p is the electron plasma frequency. The plasma is thus a strongly dispersive medium at frequencies near the peak of the Planck function, and only photons with frequencies omega >omega_p can propagate in the plasma. These effects must be taken into account in computing radiative transfer in stellar interiors. Here I first identify several late evolutionary stages in which these effects may be significant. Then I use the formalism Harris 1965 has developed to treat radiative transfer in a dispersive medium in order to derive the resulting modification of the Rosseland mean opacity kappa_R . The resulting expression is the same as that presented (without a full derivation) by Aharony & Opher 1979, who interpreted the frequency-dependent absorption coefficient kappa_ ω as that in vacuo. However, the absorption coefficient in a plasma scales from that in vacuum according to the relation kappa_ ω=n_ω(-1) kappa_ ω((vac)) (Bekefi 1966, p. 52), where n_ω equiv (kc/omega ) = [1-(omega_p (2/) omega (2)right ](1/2)) is the index of refraction of the plasma. With this correction, we find the Rosseland mean opacity to be given by the expression {1\\over \\kappa_R}={{\\int_{\\omega_p}^{\\infty} {n_{\\omega}^3 \\over \\kappa_{\\omega}^{(vac)}}{partial B_{\\omega} \\over partial T} \\bigg|_{\\omega} d\\omega} \\over{\\int_0^{\\infty}{partial B_{\\omega} \\over partial T} \\bigg|_{\\omega} d\\omega}}. This research has been supported in part by NASA grant NAGW-2444 and in part by NSF grant AST 91-15132. \\centerline{References} Aharony, U., and Opher, R. 1979, A&A, 79, 27. Bekefi, G. 1966, Radiation Processes in Plasmas, (John Wiley & Sons, Inc.: New York). Harris, E. G. 1965, Phys. Rev., 138, B479.

Omega-3 fatty acids improve appetite in cancer anorexia, but tumor resecting restores it.

PubMed

Goncalves, Carolina G; Ramos, Eduardo J B; Romanova, Irina V; Suzuki, Susumu; Chen, Chung; Meguid, Michael M

2006-02-01

Tumor growth leads to cancer anorexia that is ameliorated using omega-3 fatty acids (omega-3FA). We hypothesize that omega-3FA modulates up-regulation of hypothalamic orexigenic neuropeptide Y (NPY) and down-regulation of anorexigenic alpha melanocyte-stimulating hormone (alpha-MSH) and serotonin 1B receptors (5-HT(1B)-receptors) in tumor-bearing rats. Twenty-eight tumor-bearing rats were fed either chow (TB-Control) or omega-3FA (TB-omega-3FA). When anorexia developed in TB-Control rats, they and a cohort of TB-omega-pi-3 rats were killed. The rest had their tumor resected (R-Control and R-omega-3FA), and when anorexic TB-Controls normalized their food intake, brains were removed for hypothalamic immunocytochemical study of NPY, alpha-MSH, and 5-HT(1B)-receptor antibodies concentrations. Comparison among slides were assessed by image analysis and analyzed by ANOVA and t test. At anorexia, hypothalamic NPY in arcuate nucleus (ARC) increased by 38% in TB-omega3FA versus TB-Control, whereas alpha-MSH decreased 64% in ARC and 29% in paraventricular nucleus (PVN). Omega-3FA diet in anorexia (TB-omega-3FA vs R-omega-3FA) produced similar qualitative changes of NPY (22% increase) and alpha-MSH (31% decrease) in ARC, with concomitant decrease of 37% in 5-HT(1B)-receptors in PVN, confirming the influence of omega-3FA on the hypothalamic food intake modulators. However, after tumor resection (TB-Control vs R-Control) a 97% increase in NPY and a 62% decrease in alpha-MSH occurred that was significantly greater than in rats fed omega-3FA diet. Tumor resection and omega-3FA modifies hypothalamic food intake activity, up-regulating NPY and down-regulating alpha-MSH and 5-HT(1B)-receptors. Tumor resection in anorexic rats on chow diet restored hypothalamic NPY, alpha-MSH, and food intake quantitatively more than in rats fed omega3FA diet.

Effects of dietary omega-3 and -6 supplementations on phospholipid fatty acid composition in mice uterus during window of pre-implantation.

PubMed

Fattahi, Amir; Darabi, Masoud; Farzadi, Laya; Salmassi, Ali; Latifi, Zeinab; Mehdizadeh, Amir; Shaaker, Maghsood; Ghasemnejad, Tohid; Roshangar, Leila; Nouri, Mohammad

2018-03-01

Since fatty acid composition of uterus phospholipids is likely to influence embryo implantation, this study was conducted to investigate the effects of dietary omega-3 and -6 fatty acids on implantation rate as well as uterine phospholipid fatty acids composition during mice pre-implantation period. Sixty female mice were randomly distributed into:1) control (standard pellet), 2) omega-3 (standard pellet + 10% w/w of omega-3 fatty acids) and 3) omega-6 (standard pellet + 10% w/w of omega-6 fatty acids). Uterine phospholipid fatty acid composition during the pre-implantation window (days 1-5 of pregnancy) was analyzed using gas-chromatography. The implantation rate on the fifth day of pregnancy was also determined. Our results showed that on days 1, 2 and 3 of pregnancy, the levels of arachidonic acid (ARA) as well as total omega-6 fatty acids were significantly higher and the levels of linolenic acid and total omega-3 fatty acids were statistically lower in the omega-6 group compared to the omega-3 group (p < 0.05). On the fourth day of pregnancy, only the ARA, total omega-6 fatty acids, and poly-unsaturated fatty acids levels were significantly different between the two dietary supplemented groups (p < 0.05). There were positive correlations between the levels of omega-6 fatty acids, especially ARA, with the implantation rate. The present study showed that diets rich in omega-3 and -6 fatty acids could differently modify uterine phospholipid fatty acid composition and uterine levels of phospholipid ARA, and that the total omega-6 fatty acids had a positive association with the implantation rate. Copyright © 2017 Elsevier Inc. All rights reserved.

Predictors of Memory in Healthy Aging: Polyunsaturated Fatty Acid Balance and Fornix White Matter Integrity.

PubMed

Zamroziewicz, Marta K; Paul, Erick J; Zwilling, Chris E; Barbey, Aron K

2017-07-01

Recent evidence demonstrates that age and disease-related decline in cognition depends not only upon degeneration in brain structure and function, but also on dietary intake and nutritional status. Memory, a potential preclinical marker of Alzheimer's disease, is supported by white matter integrity in the brain and dietary patterns high in omega-3 and omega-6 polyunsaturated fatty acids. However, the extent to which memory is supported by specific omega-3 and omega-6 polyunsaturated fatty acids, and the degree to which this relationship is reliant upon microstructure of particular white matter regions is not known. This study therefore examined the cross-sectional relationship between empirically-derived patterns of omega-3 and omega-6 polyunsaturated fatty acids (represented by nutrient biomarker patterns), memory, and regional white matter microstructure in healthy, older adults. We measured thirteen plasma phospholipid omega-3 and omega-6 polyunsaturated fatty acids, memory, and regional white matter microstructure in 94 cognitively intact older adults (65 to 75 years old). A three-step mediation analysis was implemented using multivariate linear regressions, adjusted for age, gender, education, income, depression status, and body mass index. The mediation analysis revealed that a mixture of plasma phospholipid omega-3 and omega-6 polyunsaturated fatty acids is linked to memory and that white matter microstructure of the fornix fully mediates the relationship between this pattern of plasma phospholipid polyunsaturated fatty acids and memory. These results suggest that memory may be optimally supported by a balance of plasma phospholipid omega-3 and omega-6 polyunsaturated fatty acids through the preservation of fornix white matter microstructure in cognitively intact older adults. This report provides novel evidence for the benefits of plasma phospholipid omega-3 and omega-6 polyunsaturated fatty acid balance on memory and underlying white matter microstructure.

Acoustic radiation from weakly wrinkled premixed flames

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lieuwen, Tim; Mohan, Sripathi; Rajaram, Rajesh

2006-01-01

This paper describes a theoretical analysis of acoustic radiation from weakly wrinkled (i.e., u'/S{sub L}<1) premixed flames. Specifically, it determines the transfer function relating the spectrum of the acoustic pressure oscillations, P'({omega}), to that of the turbulent velocity fluctuations in the approach flow, U'({omega}). In the weakly wrinkled limit, this transfer function is local in frequency space; i.e., velocity fluctuations at a frequency {omega} distort the flame and generate sound at the same frequency. This transfer function primarily depends upon the flame Strouhal number St (based on mean flow velocity and flame length) and the correlation length, {lambda}, of themore » flow fluctuations. For cases where the ratio of the correlation length and duct radius {lambda}/a>>1, the acoustic pressure and turbulent velocity power spectra are related by P'({omega})-{omega}{sup 2}U'({omega}) and P'({omega})-U'({omega}) for St<<1 and St>>1, respectively. For cases where {lambda}/a<<1, the transfer functions take the form P'({omega})-{omega}{sup 2}({lambda}/a){sup 2}U'({omega}) and P'({omega})-{omega}{sup 2}({lambda}/a){sup 2}({psi}-{delta}ln({lambda}/a))U'({omega}) for St<<1 and St>>1, respectively, where (PS) and {delta} are constants. The latter result demonstrates that this transfer function does not exhibit a simple power law relationship in the high frequency region of the spectra. The simultaneous dependence of this pressure-velocity transfer function upon the Strouhal number and correlation length suggests a mechanism for the experimentally observed maximum in acoustic spectra and provides some insight into the controversy in the literature over how this peak should scale with the flame Strouhal number.« less

Scaling laws for homogeneous turbulent shear flows in a rotating frame

NASA Technical Reports Server (NTRS)

Speziale, Charles G.; Mhuiris, Nessan Macgiolla

1988-01-01

The scaling properties of plane homogeneous turbulent shear flows in a rotating frame are examined mathematically by a direct analysis of the Navier-Stokes equations. It is proved that two such shear flows are dynamically similar if and only if their initial dimensionless energy spectrum E star (k star, 0), initial dimensionless shear rate SK sub 0/epsilon sub 0, initial Reynolds number K squared sub 0/nu epsilon sub 0, and the ration of the rotation rate to the shear rate omega/S are identical. Consequently, if universal equilibrium states exist, at high Reynolds numbers, they will only depend on the single parameter omega/S. The commonly assumed dependence of such equilibrium states on omega/S through the Richardson number Ri=-2(omega/S)(1-2 omega/S) is proven to be inconsistent with the full Navier-Stokes equations and to constitute no more than a weak approximation. To be more specific, Richardson number similarity is shown to only rigorously apply to certain low-order truncations of the Navier-Stokes equations (i.e., to certain second-order closure models) wherein closure is achieved at the second-moment level by assuming that the higher-order moments are a small perturbation of their isotropic states. The physical dependence of rotating turbulent shear flows on omega/S is discussed in detail along with the implications for turbulence modeling.

Molecular modeling of proteinlike inclusions in lipid bilayers: lipid-mediated interactions.

PubMed

Kik, Richard A; Leermakers, Frans A M; Kleijn, J Mieke

2010-02-01

We investigated the insertion of transmembrane structures in a lipid bilayer and their interactions using self-consistent field theory. The lipids are coarse-grained on a united-atom level and consist of a phosphatidylcholinelike headgroup and two hydrophobic tails. The inclusions, acting as simple models for proteins that span biological membranes, are rigid rods (radius R ) with a hydrophobic surface and hydrophilic end caps. The insertion free energy Omega of an individual rod is strongly regulated by the affinity between its hydrophobic surface and the lipid tails. This affinity also controls the best match of the hydrophobic length of the rod with that of the bilayer. The line tension tau(=Omega/2piR) is practically independent of R . The perturbations in the bilayer as a function of distance from the inclusion, have the shape of a damped oscillation. The wavelength and decay length are related to the elastic properties of the bilayer and do not depend on R . These results are used to analyze how the lipid matrix affects the interaction between transmembrane objects, for computational reasons considering the limit of R-->infinity . Contributions on different length scales can be distinguished: (i) a long-range elastic interaction, which is an exponentially decaying oscillation; (ii) an exponentially decaying repulsion on an intermediate length scale, resulting from the loss of conformational entropy of the lipid tails; and (iii) a short-range interaction due to the finite compressibility of the lipid tails, which manifests either as a depletion attraction if there is no affinity between the tails and the inclusions' surface or, otherwise, as an oscillatory structural force.

Observation of {chi}{sub c1} Decays into Vector Meson Pairs {phi}{phi}, {omega}{omega}, and {omega}{phi}

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ablikim, M.; An, Z. H.; Bai, J. Z.

Using (106{+-}4)x10{sup 6} {psi}(3686) events accumulated with the BESIII detector at the BEPCII e{sup +}e{sup -} collider, we present the first measurement of decays of {chi}{sub c1} to vector meson pairs {phi}{phi}, {omega}{omega}, and {omega}{phi}. The branching fractions are measured to be (4.4{+-}0.3{+-}0.5)x10{sup -4}, (6.0{+-}0.3{+-}0.7)x10{sup -4}, and (2.2{+-}0.6{+-}0.2)x10{sup -5}, for {chi}{sub c1}{yields}{phi}{phi}, {omega}{omega}, and {omega}{phi}, respectively, which indicates that the hadron helicity selection rule is significantly violated in {chi}{sub cJ} decays. In addition, the measurement of {chi}{sub cJ}{yields}{omega}{phi} provides the first indication of the rate of doubly OZI-suppressed {chi}{sub cJ} decay. Finally, we present improved measurements for the branching fractionsmore » of {chi}{sub c0} and {chi}{sub c2} to vector meson pairs.« less

Omega-Omega interaction on the Lattice

NASA Astrophysics Data System (ADS)

Yamada, Masanori; Halqcd Collaboration

2014-09-01

We report our results of central potential between two Omega baryons from 2+1 flavor full Lattice QCD simulation. In the past studies, there is a possibility that some decouplet baryons have a bound state. However, almost all decuplet baryons are unstable due to decays via the strong interaction. An exception is the Omega decuplte baryon, which is stable against the strong decays, so its interaction is suitable to be investigated. It is, however, still difficult to investigate the Omega-Omega interaction experimentally due to its short-life time via weak decays. Therefore, the lattice QCD study for the Omega-Omega interaction is necessary and important. We present results obtained by the extension of the HAL QCD method to the system of two decuplet baryons. Our numerical results are obtained from 2+1 flavor full QCD gauge configurations at L ~ 2 . 9 fm mπ ~ 701 MeV and mΩ ~ 1966 MeV, generated by the PACS-CS Collaboration. We find that the Omega-Omega interaction is strong attractive, but it's not strong enough to make a bound state at out simulation set up.

Readily available sources of long-chain omega-3 oils: is farmed Australian seafood a better source of the good oil than wild-caught seafood?

PubMed

Nichols, Peter D; Glencross, Brett; Petrie, James R; Singh, Surinder P

2014-03-11

Seafood consumption enhances intake of omega-3 long-chain (≥C₂₀) polyunsaturated fatty acids (termed LC omega-3 oils). Humans biosynthesize only small amounts of LC-omega-3, so they are considered semi-essential nutrients in our diet. Concern has been raised that farmed fish now contain lower LC omega-3 content than wild-harvested seafood due to the use of oil blending in diets fed to farmed fish. However, we observed that two major Australian farmed finfish species, Atlantic salmon (Salmo salar) and barramundi (Lates calcifer), have higher oil and LC omega-3 content than the same or other species from the wild, and remain an excellent means to achieve substantial intake of LC omega-3 oils. Notwithstanding, LC omega-3 oil content has decreased in these two farmed species, due largely to replacing dietary fish oil with poultry oil. For Atlantic salmon, LC omega-3 content decreased ~30%-50% between 2002 and 2013, and the omega-3/omega-6 ratio also decreased (>5:1 to <1:1). Australian consumers increasingly seek their LC omega-3 from supplements, therefore a range of supplement products were compared. The development and future application of oilseeds containing LC omega-3 oils and their incorporation in aquafeeds would allow these health-benefitting oils to be maximized in farmed Australian seafood. Such advances can assist with preventative health care, fisheries management, aquaculture nutrition, an innovative feed/food industry and ultimately towards improved consumer health.

Determining the coordinate dependence of some components of the cubic susceptibility tensor {chi}-hat{sub yyyy}{sup (3)}(z, {omega}, -{omega}, {omega}, {omega}) of a one-dimensionally inhomogeneous absorbing plate at an arbitrary frequency dispersion

DOE Office of Scientific and Technical Information (OSTI.GOV)

Golubkov, A A; Makarov, Vladimir A

The possibility of unique reconstruction of the spatial profile of the cubic nonlinear susceptibility tensor component {chi}-hat{sub yyyy}{sup (3)}(z, {omega}, -{omega}, {omega}, {omega}) of a one-dimensionally inhomogeneous plate whose medium has a symmetry plane m{sub y} perpendicular to its surface is proved for the first time and the unique reconstruction algorithm is proposed. The amplitude complex coefficients of reflection and transmission (measured in some range of angles of incidence) as well as of conversion of an s-polarised plane signal monochromatic wave into two waves propagating on both sides of the plate make it possible to reconstruct the profile. These twomore » waves result from nonlinear interaction of a signal wave with an intense plane wave incident normally on the plate. All the waves under consideration have the same frequency {omega}, and so its variation helps study the frequency dispersion of the cubic nonlinear susceptibility tensor component {chi}-hat{sub yyyy}{sup (3)}(z, {omega}, -{omega}, {omega}, {omega}). For media with additional symmetry axes 2{sub z}, 4{sub z}, 6{sub z}, or {infinity}{sub z} that are perpendicular to the plate surface, the proposed method can be used to reconstruct the profile and to examine the frequency dispersion of about one third of all independent complex components of the tensor {chi}-hat{sup (3)}. (nonlinear-optics phenomena)« less

Readily Available Sources of Long-Chain Omega-3 Oils: Is Farmed Australian Seafood a Better Source of the Good Oil than Wild-Caught Seafood?

PubMed Central

Nichols, Peter D.; Glencross, Brett; Petrie, James R.; Singh, Surinder P.

2014-01-01

Seafood consumption enhances intake of omega-3 long-chain (≥C20) polyunsaturated fatty acids (termed LC omega-3 oils). Humans biosynthesize only small amounts of LC-omega-3, so they are considered semi-essential nutrients in our diet. Concern has been raised that farmed fish now contain lower LC omega-3 content than wild-harvested seafood due to the use of oil blending in diets fed to farmed fish. However, we observed that two major Australian farmed finfish species, Atlantic salmon (Salmo salar) and barramundi (Lates calcifer), have higher oil and LC omega-3 content than the same or other species from the wild, and remain an excellent means to achieve substantial intake of LC omega-3 oils. Notwithstanding, LC omega-3 oil content has decreased in these two farmed species, due largely to replacing dietary fish oil with poultry oil. For Atlantic salmon, LC omega-3 content decreased ~30%–50% between 2002 and 2013, and the omega-3/omega-6 ratio also decreased (>5:1 to <1:1). Australian consumers increasingly seek their LC omega-3 from supplements, therefore a range of supplement products were compared. The development and future application of oilseeds containing LC omega-3 oils and their incorporation in aquafeeds would allow these health-benefitting oils to be maximized in farmed Australian seafood. Such advances can assist with preventative health care, fisheries management, aquaculture nutrition, an innovative feed/food industry and ultimately towards improved consumer health. PMID:24618601

77 FR 2776 - Dorel Juvenile Group, Receipt of Petition for Decision of Inconsequential Noncompliance

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-19

... 22790CGT Deluxe 3 in 1 CC033BMT Alpha Omega Elite CC043ANK Alpha Omega Elite CC043ANL Alpha Omega Elite CC043AQS Alpha Omega Elite CC046AAI Deluxe 3 in 1 CC046AAU Deluxe 3 in 1 CC046CTA Deluxe 3 in 1 CC046SNW... between July 20, 2010 and May 18, 2011: 22187ANL Alpha Omega Elite 22187REM Alpha Omega Elite 22187REMA...

Omega-6/omega-3 fatty acid intake of children and older adults in the U.S.: dietary intake in comparison to current dietary recommendations and the Healthy Eating Index.

PubMed

Sheppard, Kelly W; Cheatham, Carol L

2018-03-09

Omega-6 and omega-3 fatty acids (FAs) and their ratio have been shown to affect cognitive function in children and older adults. With these analyses, we aimed to describe omega-6 and omega-3 FA intake among children and older adults in light of FA intake recommendations and with consideration of overall diet. Data were merged from two cross-sectional studies with 219 children 7 to 12 years old and one longitudinal study with 133 adults 65 to 79 years old. Demographic data, anthropometric data, and Healthy Eating Index scores were used to study relations among the omega-6 to omega-3 FA ratio and age, education, body mass index, and diet quality. FA intake, demographic, and anthropometric data were examined using partial correlations, t-tests, and analysis of variance. Most children and adults consumed at least the recommended amount of alpha-linolenic acid (LNA; omega-3) for their age and gender without consuming high amounts of linoleic acid (LA; omega-6), but did not consume sufficient eicosapentaenoic acid (EPA; omega-) and docosahexaenoic acid (DHA; omega-3). The average omega-6 to omega-3 ratios in both groups were lower than previously reported. Eating lower ratios was associated with healthier diets and consuming adequate amounts of several other nutrients. No demographic or anthropometric variables were related to FA intake in children. Adults with a college degree had significantly lower ratios than those without a college degree. American children and older adults are able to consume more balanced omega-6 to omega-3 ratios than has been indicated by commodity data. However, very few American children met even the lowest recommendations for EPA and DHA intake. Research is needed to clarify recommendations for the optimal ratio across development, which may aid in increasing EPA and DHA intake and improving health outcomes in the United States. ClinicalTrials.gov NCT02199808 13 July 2014, NCT01823419 (retrospectively registered) 20 March 2013, and NCT01515098 18 January 2012.

Nonlinear Optical Properties of High-Temperature Organic Structures

NASA Astrophysics Data System (ADS)

Shi, Rui-Fang

In this thesis, we report the discovery of a new class of electro-optic organic structures, 1,8-naphthoylene -benzimidazoles, developed with computer aided molecular design combined with actual syntheses. These structures are similar to polyimide repeat units and possess high thermal, chemical and photo stabilities. Thermal analysis shows that the new class retains its linear and nonlinear optical properties well above 300^circ C in both pure forms and guest/host polyimide systems. Importantly, side group substitutions not only increase the second-order optical responses but also enhance the thermal stability. The origin of the relatively large second order optical responses of the new class is revealed by quantum many-electron calculations that explicitly take electron -electron correlations into consideration. Contour diagrams indicate that electrons are decreased on the benzimidazole -donor-substituted side and increased on the naphthoylene side upon virtual excitations, illustrating the fact that the naphthoylene group acts both as an electron acceptor and a pi-bridge that provides the necessary electron delocalization. Results for most structures show that the most dominant virtual excitation process to beta_{ijk}(-omega _3;omega_1,omega_2) involves the ground (S_0) and first excited (S_1) pi -electronic states. Importantly, increasing the electron donor strength increase the electric dipole moments and transition moments, therefore second order optical responses are enhanced. Interestingly, it is found that the position of a donor group in the new class has a significant effect on second order optical responses. DC-induced second harmonic generation (DCSHG) dispersion measurements characterize the nonlinear optical properties of the new class, using both nanosecond and picosecond tunable laser sources ranging from 1400 to 2148 nm in wavelength. Comparison between theory and experiment demonstrates that there is good agreement between them over a wide nonresonant photon energy region, illustrating the great success of our understanding of the nonlinear optical responses even in these relatively complicated organic structures. In addition, it is found that these chromophores have large beta_{ijk }: for SY177 in solution with 1,4-dioxane, mu_{x}beta_ {x}(-2omega;omega,omega) + < gamma(-2omega;omega,omega,0) > 5kT = 418 times 10 ^{-48} esu and beta _{x}(-2omega;omega,omega ) 92 times 10^ {-30} esu at hbaromega = 0.65 eV. For SY215 in solution with CH _2Cl_2, mu_ {x}beta_{x}(-2omega; omega,omega) + < gamma( -2omega;omega,omega,0) > 5kT = 1468 times 10^{-48} esu and beta_{x}(-2omega; omega,omega) = 268 times 10^{-30} esu at hbaromega = 0.65 eV. The discovery and characterization of the new high temperature class represents a critical step in the development of new materials that are suitable for practical device applications. Work is underway to optimize these structures and incorporate them into waveguide devices.

A Comparison of Composite Reliability Estimators: Coefficient Omega Confidence Intervals in the Current Literature

ERIC Educational Resources Information Center

Padilla, Miguel A.; Divers, Jasmin

2016-01-01

Coefficient omega and alpha are both measures of the composite reliability for a set of items. Unlike coefficient alpha, coefficient omega remains unbiased with congeneric items with uncorrelated errors. Despite this ability, coefficient omega is not as widely used and cited in the literature as coefficient alpha. Reasons for coefficient omega's…

Simultaneously phase-matched second- and third-harmonic generation from 1.55 microm radiation in annealed proton-exchanged periodically poled lithium niobate waveguides.

PubMed

Marangoni, M; Lobino, M; Ramponi, R

2006-09-15

Third-harmonic generation (THG) in the cw regime from C-band radiation was achieved in annealed proton-exchanged periodically poled lithium niobate (PPLN) waveguides. By suitable design of fabrication parameters and operating conditions, quasi-phase-matching (QPM) is obtained simultaneously for the second-harmonic generation process (omega-->2omega, first-order QPM) and for the sum-frequency-generation process (omega+2omega-->3omega, third-order QPM), which provides the third harmonic of the pump field. The high overlap between the field profiles of the interacting modes--TM00 at omega and TM10 at 2omega and 3omega--results in what is believed to be the highest ever reported normalized conversion efficiency for THG from telecommunication wavelengths, equal to 0.72%W(-2) cm(-4).

Omega-3 Index and Anti-Arrhythmic Potential of Omega-3 PUFAs.

PubMed

Tribulova, Narcis; Szeiffova Bacova, Barbara; Egan Benova, Tamara; Knezl, Vladimir; Barancik, Miroslav; Slezak, Jan

2017-10-30

Omega-3 polyunsaturated fatty acids (PUFAs), namely eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are permanent subjects of interest in relation to the protection of cardiovascular health and the prevention of the incidence of both ventricular and atrial arrhythmias. The purpose of this updated review is to focus on the novel cellular and molecular effects of omega-3 PUFAs, in the context of the mechanisms and factors involved in the development of cardiac arrhythmias; to provide results of the most recent studies on the omega-3 PUFA anti-arrhythmic efficacy and to discuss the lack of the benefit in relation to omega-3 PUFA status. The evidence is in the favor of omega-3 PUFA acute and long-term treatment, perhaps with mitochondria-targeted antioxidants. However, for a more objective evaluation of the anti-arrhythmic potential of omega-3 PUFAs in clinical trials, it is necessary to monitor the basal pre-interventional omega-3 status of individuals, i.e., red blood cell content, omega-3 index and free plasma levels. In the view of evidence-based medicine, it seems to be crucial to aim to establish new approaches in the prevention of cardiac arrhythmias and associated morbidity and mortality that comes with these conditions.

A connection between domain-averaged Fermi hole orbitals and electron number distribution functions in real space.

PubMed

Francisco, E; Martín Pendás, A; Blanco, M A

2009-09-28

We show in this article how for single-determinant wave functions the one-electron functions derived from the diagonalization of the Fermi hole, averaged over an arbitrary domain Omega of real space, and expressed in terms of the occupied canonical orbitals, describe coarse-grained statistically independent electrons. With these domain-averaged Fermi hole (DAFH) orbitals, the full electron number distribution function (EDF) is given by a simple product of one-electron events. This useful property follows from the simultaneous orthogonality of the DAFH orbitals in Omega, Omega(')=R(3)-Omega, and R(3). We also show how the interfragment (shared electron) delocalization index, delta(Omega,Omega(')), transforms into a sum of one-electron DAFH contributions. Description of chemical bonding in terms of DAFH orbitals provides a vivid picture relating bonding and delocalization in real space. DAFH and EDF analyses are performed on several test systems to illustrate the close relationship between both concepts. Finally, these analyses clearly prove how DAFH orbitals well localized in Omega or Omega(') can be simply ignored in computing the EDFs and/or delta(Omega,Omega(')), and thus do not contribute to the chemical bonding between the two fragments.

Multiwire thermocouples: Frequency response

NASA Technical Reports Server (NTRS)

Forney, L. J.; Fralick, G. C.

1994-01-01

Experimental measurements are made with a novel two wire thermocouple. Signals from two wires of unequal diameters are recorded from the thermocouple suspended in constant flow with a periodic temperature fluctuation. It is demonstrated that the reconstructed signal from the two wire thermocouple requires no compensation for omega less than or equal to 2 omega(sub 1) where omega is the natural frequency of the smaller wire. A compensation factor is recommended for larger frequencies omega greater than 2 omega(sub 1). Theory and experimental measurements are compared with a novel three wire thermocouple. Signals from three wires of unequal diameters are recorded from the thermocouple suspended in constant flow with a periodic temperature fluctuation. It is demonstrated that the reconstructed signal from the three wire thermocouple requires no compensation for omega less than or equal to 5 omega(sub 1) where omega (sub 1) is the natural frequency of the smaller wire. The latter result represents a significant improvement compared to previous work with two wire thermocouples. A correction factor has also been derived to account for wires of arbitrary diameter. Measurements are recorded for multiwire thermocouples consisting of either two or three wires of unequal diameters. Signals from the multiwire probe are recorded for a reversing gas flow with a periodic temperature fluctuation. It is demonstrated that the reconstructed signal from the multiwire thermocouple requires no compensation provided omega/omega(sub 1) is less than 2.3 for two wires or omega/omega(sub 1) is less than 3.6 for three wires where omega(sub 1) is the natural frequency of the smaller wire based on the maximum gas velocity. The latter results were possible provided Fourier transformed data were used and knowledge of the gas velocity is available.

Omega-3 and omega-6 Fatty acids in blood and breast tissue of high-risk women and association with atypical cytomorphology.

PubMed

Hidaka, Brandon H; Li, Shengqi; Harvey, Katherine E; Carlson, Susan E; Sullivan, Debra K; Kimler, Bruce F; Zalles, Carola M; Fabian, Carol J

2015-05-01

The ratio of omega-3 to omega-6 fatty acids, especially the long-chain eicosapentaenoic acid (EPA) + docosahexaenoic acid (DHA) to arachidonic acid (AA) ratio, is inversely associated with breast cancer risk. We measured the association between cytologic atypia, a biomarker for short-term risk of breast cancer development, and omega-3 and omega-6 fatty acid intake and levels in blood and breast tissue. Blood and benign breast tissue, sampled by random periareolar fine-needle aspiration (RPFNA), was obtained from 70 women at elevated risk for breast cancer. Self-reported dietary intake was assessed by the NCI's Food Frequency Questionnaire. The fatty acid composition of five lipid compartments, red blood cell, plasma and breast phospholipids, and plasma and breast triaclyglycerides (TAG), was analyzed by gas chromatography as weight percent. Median daily intakes of EPA+DHA and total omega-3 fatty acids were 80 mg and 1.1 g, respectively. The median total omega-3:6 intake ratio was 1:10. Compared with women without atypia, those with cytologic atypia had lower total omega-3 fatty acids in red blood cell and plasma phospholipids and lower omega-3:6 ratios in plasma TAGs and breast TAGs (P < 0.05). The EPA+DHA:AA ratio in plasma TAGs was also lower among women with atypia. This is the first report of associations between tissue levels of omega-3 and omega-6 fatty acids and a reversible tissue biomarker of breast cancer risk. RPFNA cytomorphology could serve as a surrogate endpoint for breast cancer prevention trials of omega-3 fatty acid supplementation. ©2015 American Association for Cancer Research.

Omega-3 fatty acids (image)

MedlinePlus

Omega-3 fatty acids are a form of polyunsaturated fat that the body derives from food. Omega-3s (and omega-6s) are known as essential fatty acids (EFAs) because they are important for good health. ...

Differences in omega-3 and omega-6 polyunsaturated fatty acid consumption in people at ultra-high risk of psychosis, first-episode schizophrenia, and in healthy controls.

PubMed

Pawełczyk, Tomasz; Trafalska, Elżbieta; Pawełczyk, Agnieszka; Kotlicka-Antczak, Magdalena

2017-12-01

Supplementation with omega-3 PUFA showed efficacy in reducing the risk of transition into psychosis in UHR individuals. It is uncertain whether dietary patterns can be partly responsible for n-3 deficiencies observed in susceptible participants before the diagnosis of schizophrenia. The study was designed to assess differences in omega-3 and omega-6 PUFA consumption in healthy controls (HC), UHR participants and FES patients as well as to verify the hypothesis that dietary changes in PUFA consumption are present before active psychosis develops, that is, in UHR individuals. Dietary habits during the previous year were assessed in 34 patients at UHR of psychosis, 33 patients diagnosed with FES and 33 HC participants using a validated Food-Frequency Questionnaire and the Polish Food Composition Tables. Significant differences in omega-3 and omega-6 PUFA intake were observed between study groups. UHR and FES groups reported significantly higher consumption of omega-6 PUFA in comparison with HC. FES patients also reported a higher consumption of alpha-linolenic acid (omega-3) in comparison with HC. No significant differences were seen in consumption of long-chain marine PUFA. Differences in omega-6 and omega-3 PUFA consumption exist before development of psychotic symptoms, fulfilling the criteria of schizophrenia. © 2015 Wiley Publishing Asia Pty Ltd.

On the volume-dependence of the index of refraction from the viewpoint of the complex dielectric function and the Kramers-Kronig relation.

PubMed

Rocquefelte, Xavier; Jobic, Stéphane; Whangbo, Myung-Hwan

2006-02-16

How indices of refraction n(omega) of insulating solids are affected by the volume dilution of an optical entity and the mixing of different, noninteracting simple solid components was examined on the basis of the dielectric function epsilon(1)(omega) + iepsilon(2)(omega). For closely related insulating solids with an identical composition and the formula unit volume V, the relation [epsilon(1)(omega) - 1]V = constant was found by combining the relation epsilon(2)(omega)V = constant with the Kramers-Kronig relation. This relation becomes [n(2)(omega) - 1]V = constant for the index of refraction n(omega) determined for the incident light with energy less than the band gap (i.e., h omega < E(g)). For a narrow range of change in the formula unit volume, the latter relation is well approximated by a linear relation between n and 1/V.

Omega-3 Fatty Acid and Nutrient Deficits in Adverse Neurodevelopment and Childhood Behaviors

PubMed Central

Hibbeln, Joseph. R.; Gow, Rachel V.

2014-01-01

Synopsis Nutritional insufficiencies of omega-3 highly unsaturated fatty acids (HUFAs) may have adverse effects on brain development and neurodevelopmental outcomes. A recent meta-analysis of ten randomized controlled trials of omega-3 HUFAs reported a small to modest effect size for the efficacy of omega-3 for treating symptoms of ADHD in youth. Several controlled trials of omega-3 HUFAs combined with micronutrients (vitamins, minerals) show sizeable reductions in aggressive, antisocial, and violent behavior in youth and in young adult prisoners. Meta-analyses report efficacy for depressive symptoms in adults, and preliminary findings suggest anti-suicidal properties in adults, but studies in youth are insufficient to draw any conclusions regarding mood. Dietary adjustments to increase omega-3 and reduce omega-6 HUFA consumption are sensible recommendations for youth and adults based on general health considerations, while the evidence base for omega-3 HUFAs as potential psychiatric treatments develops. PMID:24975625

Insight into the contribution of isoprostanoids to the health effects of omega 3 PUFAs.

PubMed

Joumard-Cubizolles, Laurie; Lee, Jetty Chung-Yung; Vigor, Claire; Leung, Ho Hang; Bertrand-Michel, Justine; Galano, Jean-Marie; Mazur, André; Durand, Thierry; Gladine, Cecile

2017-11-01

Omega 3 polyunsaturated fatty acids have been reported to confer beneficial health effects notably in the field of cardiovascular and inflammatory diseases. The current knowledge suggests a significant portion of the effects of omega 3 polyunsaturated fatty acids are mediated by their oxygenated metabolites. This review attempts to cover the current literature about the contribution of specific omega 3 oxygenated metabolites, namely omega 3 isoprostanoids, which are produced through free-radical mediated oxidation. A special emphasis has been given to the most biologically relevant omega 3 polyunsaturated fatty acids namely the α-linolenic, eicosapentaenoic and docosahexaenoic acids. The review includes a comprehensive description of the biosynthetic pathways, a summary of studies related to the biological significance of omega 3 isoprostanoids as well as a critical description of analytical development in the field of omega 3 isoprostanoids profiling in biological samples. Copyright © 2017 Elsevier Inc. All rights reserved.

Original Research: Effect of various dietary fats on fatty acid profile in duck liver: Efficient conversion of short-chain to long-chain omega-3 fatty acids

PubMed Central

Chen, Xi; Du, Xue; Shen, Jianliang; Wang, Weiqun

2016-01-01

Omega-3 fatty acids, especially long-chain omega-3 fatty acids, have been associated with potential health benefits for chronic disease prevention. Our previous studies found that dietary omega-3 fatty acids could accumulate in the meat and eggs in a duck model. This study was to reveal the effects of various dietary fats on fatty acid profile and conversion of omega-3 fatty acids in duck liver. Female Shan Partridge Ducks were randomly assigned to five dietary treatments, each consisting of 6 replicates of 30 birds. The experimental diets substituted the basal diet by 2% of flaxseed oil, rapeseed oil, beef tallow, or fish oil, respectively. In addition, a dose response study was further conducted for flaxseed and fish oil diets at 0.5%, 1%, and 2%, respectively. At the end of the five-week treatment, fatty acids were extracted from the liver samples and analyzed by GC-FID. As expected, the total omega-3 fatty acids and the ratio of total omega-3/omega-6 significantly increased in both flaxseed and fish oil groups when compared with the control diet. No significant change of total saturated fatty acids or omega-3 fatty acids was found in both rapeseed and beef tallow groups. The dose response study further indicated that 59–81% of the short-chain omega-3 ALA in flaxseed oil-fed group was efficiently converted to long-chain DHA in the duck liver, whereas 1% of dietary flaxseed oil could produce an equivalent level of DHA as 0.5% of dietary fish oil. The more omega-3 fatty acids, the less omega-6 fatty acids in the duck liver. Taken together, this study showed the fatty acid profiling in the duck liver after various dietary fat consumption, provided insight into a dose response change of omega-3 fatty acids, indicated an efficient conversion of short- to long-chain omega-3 fatty acid, and suggested alternative long-chain omega-3 fatty acid-enriched duck products for human health benefits. PMID:27510581

Original Research: Effect of various dietary fats on fatty acid profile in duck liver: Efficient conversion of short-chain to long-chain omega-3 fatty acids.

PubMed

Chen, Xi; Du, Xue; Shen, Jianliang; Lu, Lizhi; Wang, Weiqun

2017-01-01

Omega-3 fatty acids, especially long-chain omega-3 fatty acids, have been associated with potential health benefits for chronic disease prevention. Our previous studies found that dietary omega-3 fatty acids could accumulate in the meat and eggs in a duck model. This study was to reveal the effects of various dietary fats on fatty acid profile and conversion of omega-3 fatty acids in duck liver. Female Shan Partridge Ducks were randomly assigned to five dietary treatments, each consisting of 6 replicates of 30 birds. The experimental diets substituted the basal diet by 2% of flaxseed oil, rapeseed oil, beef tallow, or fish oil, respectively. In addition, a dose response study was further conducted for flaxseed and fish oil diets at 0.5%, 1%, and 2%, respectively. At the end of the five-week treatment, fatty acids were extracted from the liver samples and analyzed by GC-FID. As expected, the total omega-3 fatty acids and the ratio of total omega-3/omega-6 significantly increased in both flaxseed and fish oil groups when compared with the control diet. No significant change of total saturated fatty acids or omega-3 fatty acids was found in both rapeseed and beef tallow groups. The dose response study further indicated that 59-81% of the short-chain omega-3 ALA in flaxseed oil-fed group was efficiently converted to long-chain DHA in the duck liver, whereas 1% of dietary flaxseed oil could produce an equivalent level of DHA as 0.5% of dietary fish oil. The more omega-3 fatty acids, the less omega-6 fatty acids in the duck liver. Taken together, this study showed the fatty acid profiling in the duck liver after various dietary fat consumption, provided insight into a dose response change of omega-3 fatty acids, indicated an efficient conversion of short- to long-chain omega-3 fatty acid, and suggested alternative long-chain omega-3 fatty acid-enriched duck products for human health benefits. © 2016 by the Society for Experimental Biology and Medicine.

Fish consumption in pregnancy and omega-3 status after birth are not associated with postnatal depression.

PubMed

Browne, Joanna C; Scott, Kate M; Silvers, Karen M

2006-02-01

Research to date suggests a relationship between fish consumption, omega-3 polyunsaturated fatty acids, and depression. However, interpretation of this research is difficult due to methodological limitations. Postpartum women provide an excellent opportunity to examine these relationships because omega-3s are transferred from mother to fetus during pregnancy and from mother to child after birth through breast milk. Hence new mothers are more likely to be depleted in omega-3s. Our aim was to determine whether prenatal fish consumption and omega-3 status after birth were associated with postnatal depression. Eighty first-time mothers were recruited; 41 who scored on or over the cut-off on one of two depression-screening instruments, and 39 in the control group. Depression was diagnosed using the Composite International Diagnostic Interview. Fish consumption was measured during pregnancy, and depression and omega-3 status were determined postnatally. Logistic regression and t-tests were used to examine relationships between fish consumption, omega-3 status, and postnatal depression, while controlling for known covariates. Prenatal fish consumption was not predictive of postnatal depression, and postnatal omega-3 status was not associated with postnatal depression. However, prenatal fish consumption did predict omega-3 status after birth. Prenatal fish consumption was measured using only a food frequency questionnaire, and no participants consumed oily fish (rich in omega-3s) regularly. There was no association between postnatal depression and either fish consumption in early pregnancy, or omega-3 status after birth. Our findings make it difficult to justify trials of omega-3 polyunsaturated fatty acids in the treatment of postnatal depression.

Antioxidant activity of omega-3 derivatives and their delivery via nanocages and nanocones: DFT and experimental in vivo investigation.

PubMed

Najafi, Houshang; Changizi-Ashtiyani, Saeed; Najafi, Meysam

2017-10-28

The antioxidant properties of omega-3 were investigated via experimental in vivo and theoretical methods. For experimental evaluation, oxidative stress was induced by 30 min bilateral renal ischemia and 24 h of reperfusion in male Sprague Dawley rats. The oxidative stress was evaluated through measuring malondialdehyde (MDA) and ferric reducing/antioxidant power (FRAP) levels in renal tissue. In theoretical methods, the reaction enthalpies of antioxidant mechanisms of omega-3 were calculated and the effects of NHMe, OMe, OH, Cl, and Me substituents on its antioxidant activity were investigated. Moreover, the omega-3 delivery potential by carbon and boron nitride nanocages and naocones were evaluated. The experimental results showed that omega-3 administration decreases MDA and increases FRAP levels after their changes by ischemia/reperfusion. Theoretical results indicated that NHMe and OMe substituents can significantly improve the antioxidant activity of omega-3. Also, boron nitride nanocone (BNNC) has higher |∆E ad | values, so it has higher potential for omega-3 delivery. Taken together, the new findings presented here indicate that omega-3 has anti-oxidative properties and NHMe and OMe substituents can improve its antioxidant activity. Moreover, adsorption of omega-3 on the surface of the studied nanostructures was exothermic, and BNNC with higher |∆Ead| values has higher potential for omega-3 delivery. Graphical abstract The interaction and adsorption of BNNC with omega-3 is exothermic and experimentally possible from the energetic viewpoint, so the BNNC with higher |∆E ad | and |∆G ad | values has higher potential for omega-3 delivery.

Impedance-spectroscopy analysis of a LiTaO{sub 3}-type single crystal

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ming, D.; Reau, J.M.; Ravez, J.

1995-04-01

Low-frequency dielectric dispersion phenomena in a LiTaO{sub 3}-type single crystal have been analyzed by impedance spectroscopy in directions parallel and perpendicular to the polar c-axis (rhombohedral system). An empirical expression has been deduced for the complex permittivity {epsilon}*({omega}), {epsilon}*({omega}) = {epsilon}{infinity} + {sup {epsilon}{sub s}-{epsilon}{infinity}}/{sub 1 + (i{omega}/{omega}{sub 1}){sup m}} + {sup {sigma}{sub 0}}/{sub {epsilon}{sub 0}{omega}} [1 + (i{omega}/{omega}{sub 2}){sup n}], where the ({omega}{sub 1}, m) and ({omega}{sub 2}, n) couples characterize respectively the lattice and the charge carrier responses. This relation may be considered as a generalization of the Cole-Cole dielectric expression. Excellent agreement has been obtained in amore » wide frequency domain (1-10{sup 6} Hz) between the measured and calculated permittivities in the 500-650{degrees}C temperature range ({Tc} = 600{degrees}C). The temperature dependence of various dielectrical parameters has been determined and discussed. The relaxations are correlated to Li atom motions.« less

Omega flight-test data reduction sequence. [computer programs for reduction of navigation data

NASA Technical Reports Server (NTRS)

Lilley, R. W.

1974-01-01

Computer programs for Omega data conversion, summary, and preparation for distribution are presented. Program logic and sample data formats are included, along with operational instructions for each program. Flight data (or data collected in flight format in the laboratory) is provided by the Ohio University Omega receiver base in the form of 6-bit binary words representing the phase of an Omega station with respect to the receiver's local clock. All eight Omega stations are measured in each 10-second Omega time frame. In addition, an event-marker bit and a time-slot D synchronizing bit are recorded. Program FDCON is used to remove data from the flight recorder tape and place it on data-processing cards for later use. Program FDSUM provides for computer plotting of selected LOP's, for single-station phase plots, and for printout of basic signal statistics for each Omega channel. Mean phase and standard deviation are printed, along with data from which a phase distribution can be plotted for each Omega station. Program DACOP simply copies the Omega data deck a controlled number of times, for distribution to users.

Breast milk docosahexaenoic acid (DHA) correlates with DHA status of malnourished infants.

PubMed

Smit, E N; Oelen, E A; Seerat, E; Muskiet, F A; Boersma, E R

2000-06-01

To investigate whether low docosahexaenoic acid (22:6omega3; DHA) status of malnourished, mostly breast fed infants is a result of low omega3 fatty acid intake via breast milk. Fatty acid composition of breast milk of eight Pakistani mothers, and of the erythrocytes of their malnourished children was analysed. The milk of the Pakistani mothers contained low percentages of all omega3 and most omega6 fatty acids, compared with milk of Dutch mothers. Breast milk DHA was positively correlated with infant erythrocyte DHA and arachidonic acid (20:4omega6). DHA status of these malnourished children is strongly dependent on the omega3 fatty acid intake from breast milk. Augmentation of the infants' omega3 long chain polyunsaturated fatty acid status, or the omega3 and omega6 fatty acid status in general, by supplementation is indicated in deprived circumstances where access to fresh fish is difficult. However, in terms of prevention, maternal supplementation of these long chain polyunsaturated fatty acids, preferably from early pregnancy onwards, may be a better option.

New directions in the CernVM file system

NASA Astrophysics Data System (ADS)

Blomer, Jakob; Buncic, Predrag; Ganis, Gerardo; Hardi, Nikola; Meusel, Rene; Popescu, Radu

2017-10-01

The CernVM File System today is commonly used to host and distribute application software stacks. In addition to this core task, recent developments expand the scope of the file system into two new areas. Firstly, CernVM-FS emerges as a good match for container engines to distribute the container image contents. Compared to native container image distribution (e.g. through the “Docker registry”), CernVM-FS massively reduces the network traffic for image distribution. This has been shown, for instance, by a prototype integration of CernVM-FS into Mesos developed by Mesosphere, Inc. We present a path for a smooth integration of CernVM-FS and Docker. Secondly, CernVM-FS recently raised new interest as an option for the distribution of experiment conditions data. Here, the focus is on improved versioning capabilities of CernVM-FS that allows to link the conditions data of a run period to the state of a CernVM-FS repository. Lastly, CernVM-FS has been extended to provide a name space for physics data for the LIGO and CMS collaborations. Searching through a data namespace is often done by a central, experiment specific database service. A name space on CernVM-FS can particularly benefit from an existing, scalable infrastructure and from the POSIX file system interface.

Analytical electron microscope study of the omega phase transformation in a zirconium-niobium alloy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zaluzec, N. J.

1979-01-01

The study of the as-quenched omega phase morphology shows that the domain size of Zr-15% Nb is on the order of 30 A. No alignment of omega domains along <222>..beta.. directions was observed and samples having undergone thermal cycling in thin foil form, did not develop a long-period structure of alternating ..beta.. and ..omega.. phases below the omega transformation temperature. (FS)

Omega-3 Index and Anti-Arrhythmic Potential of Omega-3 PUFAs

PubMed Central

Tribulova, Narcis; Szeiffova Bacova, Barbara; Egan Benova, Tamara; Knezl, Vladimir; Barancik, Miroslav; Slezak, Jan

2017-01-01

Omega-3 polyunsaturated fatty acids (PUFAs), namely eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are permanent subjects of interest in relation to the protection of cardiovascular health and the prevention of the incidence of both ventricular and atrial arrhythmias. The purpose of this updated review is to focus on the novel cellular and molecular effects of omega-3 PUFAs, in the context of the mechanisms and factors involved in the development of cardiac arrhythmias; to provide results of the most recent studies on the omega-3 PUFA anti-arrhythmic efficacy and to discuss the lack of the benefit in relation to omega-3 PUFA status. The evidence is in the favor of omega-3 PUFA acute and long-term treatment, perhaps with mitochondria-targeted antioxidants. However, for a more objective evaluation of the anti-arrhythmic potential of omega-3 PUFAs in clinical trials, it is necessary to monitor the basal pre-interventional omega-3 status of individuals, i.e., red blood cell content, omega-3 index and free plasma levels. In the view of evidence-based medicine, it seems to be crucial to aim to establish new approaches in the prevention of cardiac arrhythmias and associated morbidity and mortality that comes with these conditions. PMID:29084142

Omega-3 Index of Canadian adults.

PubMed

Langlois, Kellie; Ratnayake, Walisundera M N

2015-11-01

Cardioprotective properties have been associated with two fatty acids-eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). The Omega-3 Index indicates the percentage of EPA+DHA in red blood cell fatty acids. Omega-3 Index levels of the Canadian population have not been directly measured. Data for respondents aged 20 to 79 from cycle 3 (2012/2013) of the Canadian Health Measures Survey were used to calculate means and the prevalence of Omega-3 Index coronary heart disease (CHD) risk cut-offs-high (4% or less), moderate (more than 4% to less than 8%), and low (8% or more)-by sociodemographic and lifestyle characteristics, including fish consumption and use of omega-3 supplements. Associations between the Omega-3 Index and CHD-related factors including biomarkers, risk factors, and previous CHD events, were examined in multivariate regression models. The mean Omega-3 Index level of Canadians aged 20 to 79 was 4.5%. Levels were higher for women, older adults, Asians and other non-white Canadians, omega-3 supplement users, and fish consumers; levels were lower for smokers and people who were obese. Fewer than 3% of adults had levels associated with low CHD risk; 43% had levels associated with high risk. No CHD-related factor was associated with the Omega-3 Index when control variables were taken into account. Omega-3 Index levels among Canadian adults were strongly related to age, race, supplement use, fish consumption, smoking status and obesity. Fewer than 3% of adults had Omega-3 Index levels associated with low risk for CHD.

Nuts and Your Heart: Eating Nuts for Heart Health

MedlinePlus

... monounsaturated and polyunsaturated fats — lower bad cholesterol levels. Omega-3 fatty acids. Omega-3 fatty acids are found in many kinds of fish, but many nuts are also rich in omega-3 fatty acids. Omega-3s are a healthy form ...

7 Things to Know about Omega-3 Fatty Acids

MedlinePlus

... X Y Z 7 Things To Know About Omega-3 Fatty Acids Share: Omega-3 fatty acids are a group of polyunsaturated fatty ... a number of functions in the body. The omega-3 fatty acids EPA and DHA are found in ...

Tunneling ionization and harmonic generation in two-color fields

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kondo, K.; Kobayashi, Y.; Sagisaka, A.

1996-02-01

Tunneling ionization and harmonic generation in two-color fields were studied with a fundamental beam ({omega}) and its harmonics (2{omega},3{omega}), which were generated by a 100-fs Ti:sapphire laser. Ion yields of atoms and molecules were successfully controlled by means of a change in the relative phase between {omega} and 3{omega} pulses. Two-color interference was clearly observed in photoelectron spectra and harmonic spectra. In the {omega}{endash}2{omega} field even-order harmonics were observed in which the intensity was almost equal to that of the odd harmonics because of an asymmetric optical field. These results were compared with the quasi-static model for ionization and withmore » the quantum theory for harmonic generation. {copyright} {ital 1996 Optical Society of America.}« less

On Spectral Invariance of Single Scattering Albedo for Weakly Absorbing Wavelengths

NASA Technical Reports Server (NTRS)

Marshak, Alexander; Knyazikhin, Yuri; Chiu, J. Christine; Wiscombe, Warren J.

2011-01-01

This note shows that for water droplets at weakly absorbing wavelengths, the ratio omega(sub O lambda(r))/omega(sub O lambda(r(sub O)) of two single scattering albedo spectra, omega(sub O lambda(r) and omega(sub O lambda(r (sub O)), is a linear function of omega(sub O lambda(r). The slope and intercept of the linear function are wavelength independent and sum to unity. This relationship allows for a representation of any single scattering albedo omega(sub O lambda(r) via one known spectrum omega(sub O lambda(r(sub O)). The note provides a simple physical explanation of the discovered relationship. In addition to water droplets, similar linear relationships were found for the single scattering albedo of non-spherical ice crystals.

Analysis of OMEGA/Mars Express data hyperspectral data using a Multiple-Endmember Linear Spectral Unmixing Model (MELSUM): Methodology and first results

NASA Astrophysics Data System (ADS)

OMEGA Science Team; Combe, J.-Ph.; Le Mouélic, S.; Sotin, C.; Gendrin, A.; Mustard, J. F.; Le Deit, L.; Launeau, P.; Bibring, J.-P.; Gondet, B.; Langevin, Y.; Pinet, P.; OMEGA Science Team

2008-05-01

The mineralogical composition of the Martian surface is investigated by a Multiple-Endmember Linear Spectral Unmixing Model (MELSUM) of the Observatoire pour la Minéralogie, l'Eau, les Glaces et l'Activité (OMEGA) imaging spectrometer onboard Mars Express. OMEGA has fully covered the surface of the red planet at medium to low resolution (2-4 km per pixel). Several areas have been imaged at a resolution up to 300 m per pixel. One difficulty in the data processing is to extract the mineralogical composition, since rocks are mixtures of several components. MELSUM is an algorithm that selects the best linear combination of spectra among the families of minerals available in a reference library. The best fit of the observed spectrum on each pixel is calculated by the same unmixing equation used in the classical Spectral Mixture Analysis (SMA). This study shows the importance of the choice of the input library, which contains in our case 24 laboratory spectra (endmembers) of minerals that cover the diversity of the mineral families that may be found on the Martian surface. The analysis is restricted to the 1.0-2.5 μm wavelength range. Grain size variations and atmospheric scattering by aerosols induce changes in overall albedo level and continuum slopes. Synthetic flat and pure slope spectra have therefore been included in the input mineral spectral endmembers library in order to take these effects into account. The selection process for the endmembers is a systematic exploration of whole set of combinations of four components plus the straight line spectra. When negative coefficients occur, the results are discarded. This strategy is successfully tested on the terrestrial Cuprite site (Nevada, USA), for which extensive ground observations exist. It is then applied to different areas on Mars including Syrtis Major, Aram Chaos and Olympia Undae near the North Polar Cap. MELSUM on Syrtis Major reveals a region dominated by mafic minerals, with the oldest crustal regions composed of a mixing between low-calcium pyroxenes (LCPs) (orthopyroxenes (OPx)) and high-calcium pyroxenes (HCPs) (clinopyroxenes (CPx)). The Syrtis volcanic edifice appears depleted in LCP (OPx) and enriched in HCP (CPx), which is consistent with materials produced with a lower partial fusion degree at an age younger to the surrounding crust. Strong olivine signatures are found between the two calderas Nili Patera and Meroe Patera and in Nili Fossae. A strong signature of iron oxides is found within Aram Chaos, with a spatial distribution also consistent with thermal emission spectrometer (TES). Gypsum is unambiguously detected in the northern polar region, in agreement with the study of Langevin et al. [2005. Sulfates in the north polar region of Mars detected by OMEGA/Mars Express. Science 307(5715), 1584-1586]. Our results show that the linear spectral unmixing provides good first order results in a variety of mineralogical contexts, and can therefore confidently be used on a wider scale to analyze the complete archive of OMEGA data.

The body composition and lipid metabolic effects of long-term ethanol feeding during a high omega 6 polyunsaturated fatty acid diet in micropigs.

PubMed

Nakamura, M T; Tang, A B; Villanueva, J; Halsted, C H; Phinney, S D

1993-10-01

Our previous research with miniature pigs has shown that long-term ethanol feeding with a low-fat diet decreases arachidonic acid (20:4 omega 6) levels in multiple tissues, but we did not find significant liver pathology. In this study, we investigated the effect of ethanol feeding with high dietary linoleic acid (18:2 omega 6) on tissue fatty acid (FA) profiles and body composition. Five Yucatan micropigs were fed 370 kJ (89 kcal)/kg body weight of a diet containing ethanol and fat as 40% and 34% of energy, respectively; five control pigs were pair-fed corn starch in place of ethanol. Corn oil, 61% 18:2 omega 6, supplied most of the dietary fat. Liver biopsies were performed at baseline (n = 2 per group) and at three other time points (n = 5 per group). Phospholipid (PL) FA levels were measured by thin-layer and gas chromatography. Body composition was analyzed by underwater weighing of carcasses. Body composition analysis demonstrated a marked reduction of carcass fat in the ethanol group, but no significant reduction of carcass lean weight after 12 months. In liver PLs, the ethanol group showed decreased 20:4 omega 6 and docosahexaenoic acid (22:6 omega 3) after 1 month. While the decreased 20:4 omega 6 remained constant after 1 month, 22:6 omega 3 showed a progressive decrease up to 12-months, resulting in a continuous decrease of the omega 3/omega 6 FA ratio. This slowly progressive decrease in the omega 3/omega 6 ratio in liver PLs with ethanol feeding may have enhanced the inflammatory response in the liver, contributing to liver pathology. Body composition results indicate marked wasting of energy in the ethanol group.

Influence of Omega-3 Fatty Acid Status on the Way Rats Adapt to Chronic Restraint Stress

PubMed Central

Hennebelle, Marie; Balasse, Laure; Latour, Alizée; Champeil-Potokar, Gaelle; Denis, Stéphanie; Lavialle, Monique; Gisquet-Verrier, Pascale; Denis, Isabelle; Vancassel, Sylvie

2012-01-01

Omega-3 fatty acids are important for several neuronal and cognitive functions. Altered omega-3 fatty acid status has been implicated in reduced resistance to stress and mood disorders. We therefore evaluated the effects of repeated restraint stress (6 h/day for 21 days) on adult rats fed omega-3 deficient, control or omega-3 enriched diets from conception. We measured body weight, plasma corticosterone and hippocampus glucocorticoid receptors and correlated these data with emotional and depression-like behaviour assessed by their open-field (OF) activity, anxiety in the elevated-plus maze (EPM), the sucrose preference test and the startle response. We also determined their plasma and brain membrane lipid profiles by gas chromatography. Repeated restraint stress caused rats fed a control diet to lose weight. Their plasma corticosterone increased and they showed moderate behavioural changes, with increases only in grooming (OF test) and entries into the open arms (EPM). Rats fed the omega-3 enriched diet had a lower stress-induced weight loss and plasma corticosterone peak, and reduced grooming. Rats chronically lacking omega-3 fatty acid exhibited an increased startle response, a stress-induced decrease in locomotor activity and exaggerated grooming. The brain omega-3 fatty acids increased as the dietary omega-3 fatty acids increased; diets containing preformed long-chain omega-3 fatty acid were better than diets containing the precursor alpha-linolenic acid. However, the restraint stress reduced the amounts of omega-3 incorporated. These data showed that the response to chronic restraint stress was modulated by the omega-3 fatty acid supply, a dietary deficiency was deleterious while enrichment protecting against stress. PMID:22860066

Omega-3 Polyunsaturated Fatty Acids Enriched Hen Eggs Consumption Enhances Microvascular Reactivity in Young Healthy Individuals.

PubMed

Stupin, Ana; Rasic, Lidija; Matic, Anita; Stupin, Marko; Kralik, Zlata; Kralik, Gordana; Grcevic, Manuela; Drenjancevic, Ines

2018-04-10

Whilst the beneficial effect of omega-3 polyunsaturated fatty acids (PUFAs) supplementation on cardiovascular (CV) system is well supported in CV patients, the effect of consumption of omega-3 PUFAs enriched functional food in healthy individuals is still not fully elucidated. This study aimed to determine the effect of consumption of omega-3 PUFAs enriched hen eggs on microvascular reactivity (primary outcome), blood pressure (BP) and serum lipid profile in young healthy individuals. Control group (N=16) ate three ordinary hen eggs (277 mg omega-3 PUFAs/day), and OMEGA-3 group (N=20) ate three omega-3 PUFAs enriched eggs containing 259 mg of omega-3 PUFAs/egg daily (ALA 167 mg/egg, EPA 7 mg/egg, DHA 84 mg/egg) for 3 weeks (777 mg omega-3 PUFAs/day). Post-occlusive reactive hyperemia (PORH) in skin microcirculation assessed by laser Doppler flowmetry, serum lipid profile, fasting blood glucose, high-sensitivity C-reactive protein (hsCRP) and arterial BP were measured in all subjects before and after the protocol. PORH was significantly enhanced, and triglycerides, hsCRP and BP were significantly decreased in OMEGA-3 group compared to baseline measurement, while there was no significant difference in Control group after the protocol compared to baseline. This is the first study to demonstrate that consumption of a mixture of omega-3 PUFAs (ALA+EPA+DHA), provided via enriched hen eggs, elicits changes in microvascular reactivity, BP and triglycerides level in healthy subjects that are associated with CV benefits, thus suggesting that daily consumption of omega-3 PUFAs enriched eggs in healthy individuals may potentially contribute to CV risk factors attenuation and disease prevention.

Omega-3/Omega-6 Fatty Acids for Attention Deficit Hyperactivity Disorder: A Randomized Placebo-Controlled Trial in Children and Adolescents

ERIC Educational Resources Information Center

Johnson, Mats; Ostlund, Sven; Fransson, Gunnar; Kadesjo, Bjorn; Gillberg, Christopher

2009-01-01

Objective: The aim of the study was to assess omega 3/6 fatty acids (eye q) in attention deficit hyperactivity disorder (ADHD). Method: The study included a randomized, 3-month, omega 3/6 placebo-controlled, one-way crossover trial with 75 children and adolescents (8-18 years), followed by 3 months with omega 3/6 for all. Investigator-rated ADHD…

Comparison of Aerosol Single Scattering Albedos Derived by Diverse Techniques In Two North Atlantic Experiments

NASA Technical Reports Server (NTRS)

Russell, P. B.; Redemann, J.; Schmid, B.; Bergstrom, R. W.; Livingston, J. M.; McIntosh, D. M.; Ramirez, S. A.; Hartley, S.; Hobbs, P. V.; Quinn, P. K.

2002-01-01

Aerosol single scattering albedo omega (the ratio of scattering to extinction) is important in determining aerosol climatic effects, in explaining relationships between calculated and measured radiative fluxes, and in retrieving aerosol optical depths from satellite radiances. Recently, two experiments in the North Atlantic region, the Tropospheric Aerosol Radiative Forcing Observational Experiment (TARFOX) and the Second Aerosol Characterization Experiment (ACE-2), determined aerosol omega by a variety of techniques. The techniques included fitting of calculated to measured radiative fluxes; retrievals of omega from skylight radiances; best fits of complex refractive index to profiles of backscatter extinction, and size distribution; and in situ measurements of scattering and absorption at the surface and aloft. Both TARFOX and ACE-2 found a fairly wide range of values for omega at midvisable wavelengths approx. 550 nm, with omega(sub midvis) greater than or equal to 0.85 and less than or equal to 0.99 for the marine aerosol impacted by continental pollution. Frequency distributions of omega could usually be approximated by lognormals in omega(sub max) - omega, with some occurrence of bimodality, suggesting the influence of different aerosol sources or processing. In both TARFOX and ACE-2, closure tests between measured and calculated radiative fluxes yielded best-fit values of omega(sub midvis) 0.90 +/- 0.04 for the polluted boundary layer. Although these results have the virtue of describing the column aerosol unperturbed by sampling, they are subject to questions about representativeness and other uncertainties (e.g., thermal offsets, unknown gas absorption) The other techniques gave larger values for omega(sub midvis) for the polluted boundary layer, with a typical result of omega(sub midvis) = 0.95 +/- 0.04. Current uncertainties in omega are large in terms of climate effects More tests are needed of the consistency among different methods and of humidification effects on omega.

Effects of Diets High in Unsaturated Fatty Acids on Socially Induced Stress Responses in Guinea Pigs

PubMed Central

Nemeth, Matthias; Millesi, Eva; Wagner, Karl-Heinz; Wallner, Bernard

2014-01-01

Unsaturated fatty acids (UFAs), such as omega-3 and omega-6 poly- and omega-9 monounsaturated fatty acids are important nutrients and major components of neuronal cell membranes. They play a major role in modulating brain functions and physiology and may therefore diminish behavioral and physiological stress reactions in corroboration with decreased cortisol concentrations. Functionally, cortisol itself can modulate several behaviors and also the fatty acid metabolism in the long term. But only little is known about the behavioral and physiological influences of dietary UFAs in a social group, where individuals are regularly exposed to stressful situations. Therefore, the aim of this study was to determine the effects of dietary UFAs on saliva cortisol concentrations and behavioral responses in socially confronted guinea pigs. Three groups of animals were additionally supplemented with 500 mg chia seeds (high in omega-3), walnuts (high in omega-6), or peanuts (high in omega-9) per kg bodyweight each day and compared to a control group. During social confrontation saliva cortisol concentrations significantly increased in all groups, which was accompanied by a loss in bodyweight. However, cortisol levels remained lower in the chia and walnut groups compared to controls. Additionally, the walnut group displayed significantly increased locomotion, while no differences between groups were detected in socio-positive, sexual, or aggressive behaviors. Total plasma omega-3, omega-6, and omega-9 fatty acids were significantly increased in the corresponding groups, due to the dietary supplementations. However, a significant decrease in plasma omega-3 and an increase in plasma n-6 fatty acids were detected in the chia group when comparing the measurements before and after social confrontation. We conclude that both omega-3 and omega-6 polyunsaturated fatty acids can diminish behavioral and physiological stress responses to the social environment, enabling individuals to cope with social stressors, but at the expense of plasma derived omega-3 fatty acids. PMID:25551380

Effect of omega-3 fatty acids on canine atopic dermatitis.

PubMed

Mueller, R S; Fieseler, K V; Fettman, M J; Zabel, S; Rosychuk, R A W; Ogilvie, G K; Greenwalt, T L

2004-06-01

Twenty-nine dogs were included in a double-blinded, placebo-controlled, randomised trial and were orally supplemented for 10 weeks with either flax oil (200 mg/kg/day), eicosapentaenoic acid (50 mg/kg/day) and docosahexaenoic acid (35 mg/kg/day) in a commercial preparation, or mineral oil as a placebo. For each dog, clinical scores were determined based on a scoring system developed prior to the trial. Total omega-6 and omega-3 intake and the ratio of omega-6:omega-3 (omega-6:3) were calculated before and after the trial. The dogs' clinical scores improved in those supplemented with flax oil and the commercial preparation, but not in the placebo group. No correlation was identified between total fatty acid intake or omega-6:3 ratio and clinical scores. Based on the results of this study, the total intake of fatty acids or the omega-6:3 ratio do not seem to be the main factors in determining the clinical response.

A computational search for lipases that can preferentially hydrolyze long-chain omega-3 fatty acids from fish oil triacylglycerols.

PubMed

Kamal, Md Zahid; Barrow, Colin J; Rao, Nalam Madhusudhana

2015-04-15

Consumption of long-chain omega-3 fatty acids is known to decrease the risk of major cardiovascular events. Lipases, a class of triacylglycerol hydrolases, have been extensively tested to concentrate omega-3 fatty acids from fish oils, under mild enzymatic conditions. However, no lipases with preference for omega-3 fatty acids selectivity have yet been discovered or developed. In this study we performed an exhaustive computational study of substrate-lipase interactions by docking, both covalent and non-covalent, for 38 lipases with a large number of structured triacylglycerols containing omega-3 fatty acids. We identified some lipases that have potential to preferentially hydrolyze omega-3 fatty acids from structured triacylglycerols. However omega-3 fatty acid preferences were found to be modest. Our study provides an explanation for absence of reports of lipases with omega-3 fatty acid hydrolyzing ability and suggests methods for developing these selective lipases. Copyright © 2014 Elsevier Ltd. All rights reserved.

Vitamin E supplementation modulates the biological effects of omega-3 fatty acids in naturally aged rats.

PubMed

Narayanankutty, Arunaksharan; Kottekkat, Anagha; Mathew, Shaji E; Illam, Soorya P; Suseela, Indu M; Raghavamenon, Achuthan C

2017-03-01

Omega-3 fatty acids are well-known class of nutraceuticals with established health benefits. Recently, the oxidation products of these fatty acids are gaining attention, as they are likely to disturb body redox balance. Therefore, the efficacy of omega-3 fats under conditions of diminished antioxidant status, such as aging, is always a concern. Present study assessed the effects of omega-3 fats (DHA and EPA) together with or without vitamin-E in naturally aged rats. It was found that in omega-3 fats alone consumed rats the lipid profile was improved, while in omega-3 fat with vitamin-E-consumed group (OMVE), the hepato protective and antioxidant properties were pronounced, especially the redox status of brain tissue. It is possible that vitamin-E might have reduced the peroxidation of omega-3 fats, thereby allowing their synergistic effects. Hence, the use of vitamin-E along with omega-3 fat may be beneficial under aged conditions.

Evolutionary aspects of diet: the omega-6/omega-3 ratio and the brain.

PubMed

Simopoulos, Artemis P

2011-10-01

Several sources of information suggest that human beings evolved on a diet that had a ratio of omega-6 to omega-3 fatty acids (FA) of about 1/1; whereas today, Western diets have a ratio of 10/1 to 20-25/1, indicating that Western diets are deficient in omega-3 FA compared with the diet on which humans evolved and their genetic patterns were established. Omega-6 and omega-3 FA are not interconvertible in the human body and are important components of practically all cell membranes. Studies with nonhuman primates and human newborns indicate that docosahexaenoic acid (DHA) is essential for the normal functional development of the brain and retina, particularly in premature infants. DHA accounts for 40% of the membrane phospholipid FA in the brain. Both eicosapentaenoic acid (EPA) and DHA have an effect on membrane receptor function and even neurotransmitter generation and metabolism. There is growing evidence that EPA and DHA could play a role in hostility and violence in addition to the beneficial effects in substance abuse disorders and alcoholism. The balance of omega-6 and omega-3 FA is important for homeostasis and normal development throughout the life cycle.

Coherent generation of the terrestrial kilometric radiation by nonlinear beatings between electrostatic waves

NASA Technical Reports Server (NTRS)

Roux, A.; Pellat, R.

1978-01-01

The propagation of electrostatic plasma waves in an inhomogeneous and magnetized plasma was studied. These waves, which are driven unstable by auroral beams of electrons, are shown to suffer a further geometrical amplification while they propagate towards resonances. Simultaneously, their group velocities tend to be aligned with the geomagnetic field. It is shown that the electrostatic energy tends to accumulate at, or near omega sub LH and omega sub UH, the local lower and upper hybrid frequencies. Due to this process, large amplitude electrostatic waves with very narrow spectra are observed near these frequencies at any place along the auroral field lines where intense beam driven instability takes place. These intense quasi-monochromatic electrostatic waves are shown to give rise to an intense electromagnetic radiation. Depending upon the ratio omega sub pe/omega sub ce between the electron plasma frequency and the electron gyro-frequency the electromagnetic wave can be radiated in the ordinary mode (at omega sub UH), or in the extraordinary (at 2 omega sub UH). As the ratio omega sub pe/omega sub ce tends to be rather small, it is shown that the most intense radiation should be boserved at 2 omega sub UH in the extraordinary mode.

40 CFR 721.10286 - Formaldehyde, polymer with .alpha.- (2-aminomethylethyl)- .omega. - (2 - aminomethylethoxy)poly...

Code of Federal Regulations, 2013 CFR

2013-07-01

...-aminomethylethyl)- .omega. - (2 - aminomethylethoxy)poly[ oxy(methyl - 1,2 - ethanediyl)] and 4 - (1,1... Specific Chemical Substances § 721.10286 Formaldehyde, polymer with .alpha.- (2-aminomethylethyl)- .omega... formaldehyde, polymer with .alpha.-(2-aminomethylethyl)-.omega.-(2-aminomethylethoxy)poly[oxy(methyl-1,2...

Characterization of Ca2+ channel currents in cultured rat cerebellar granule neurones.

PubMed

Pearson, H A; Sutton, K G; Scott, R H; Dolphin, A C

1995-02-01

1. High-threshold voltage-gated calcium channel currents (IBa) were studied in cultured rat cerebellar granule neurones using the whole-cell patch clamp technique with 10 mM Ba2+ as the charge carrier. The putative P-type component of whole-cell current was characterized by utilizing the toxin omega-agatoxin IVA (omega-Aga IVA) in combination with other blockers. 2. omega-Aga IVA (100 nM) inhibited the high voltage-activated (HVA) IBa by 40.9 +/- 3.4% (n = 27), and the dissociation constant Kd was 2.7 nM. Maximal inhibition occurred within a 2-3 min time course, and was irreversible. The isolated omega-Aga IVA-sensitive current was non-inactivating. 3. omega-Aga IVA exhibited overlapping selectivity with both N- and L-channel blockers; omega-conotoxin GVIA (omega-CTX GVIA) (1 microM) and the dihydropyridine (-)-202-709 (1 microM), respectively. Together these toxins reduced the omega-Aga IVA-sensitive component to just 4.5 +/- 1.4% (n = 3). Thus only a small proportion of the current can be unequivocally attributed to P-type current. Inhibition of the HVA IBa by omega-Aga IA also reduced the proportion of omega-Aga IVA-sensitive current to 28.0 +/- 3.2% (n = 3). 4. Application of omega-Aga IVA and a synthetic form of funnel-web toxin, N-(7-amino-4-azaheptyl)-L-argininamide (sFTX-3.3; 10 microM), produced an additive block of the HVA IBa. Consequently these two toxins do not act on the same channel in cerebellar granule neurones. 5. omega-Aga IVA inhibition of low voltage-activated (LVA) IBa was studied in the ND7-23 neuronal cell line. omega-Aga IVA (100 nM) reduced the LVA current by 41.3 +/- 3.2% (n = 17) in a fully reversible manner with no shift in the steady-state inactivation of the channel. 6. A component of current insensitive to N-, L- and P-channel blockers remained unclassified in all our studies. This component, and also that remaining following block by omega-Aga IVA and omega-Aga IA, exhibited relatively rapid, although incomplete, inactivation compared to the other currents isolated in this study. 7. In conclusion, omega-Aga IVA inhibits a component of current in cultured cerebellar granule neurones which overlaps almost completely with that inhibited by L- and N-channel blockers. In addition, a large component of whole-cell current in these neurones still remains unclassified.

Omega 3 fatty acids for prevention and treatment of cardiovascular disease

PubMed Central

Hooper, Lee; Harrison, Roger A; Summerbell, Carolyn D; Moore, Helen; Worthington, Helen V; Ness, Andrew; Capps, Nigel; Smith, George Davey; Riemersma, Rudolph; Ebrahim, Shah

2014-01-01

Background It has been suggested that omega 3 (W3, n-3 or omega-3) fats from oily fish and plants are beneficial to health. Objectives To assess whether dietary or supplemental omega 3 fatty acids alter total mortality, cardiovascular events or cancers using both RCT and cohort studies. Search methods Five databases including CENTRAL, MEDLINE and EMBASE were searched to February 2002. No language restrictions were applied. Bibliographies were checked and authors contacted. Selection criteria RCTs were included where omega 3 intake or advice was randomly allocated and unconfounded, and study duration was at least six months. Cohorts were included where a cohort was followed up for at least six months and omega 3 intake estimated. Data collection and analysis Studies were assessed for inclusion, data extracted and quality assessed independently in duplicate. Random effects meta-analysis was performed separately for RCT and cohort data. Main results Forty eight randomised controlled trials (36,913 participants) and 41 cohort analyses were included. Pooled trial results did not show a reduction in the risk of total mortality or combined cardiovascular events in those taking additional omega 3 fats (with significant statistical heterogeneity). Sensitivity analysis, retaining only studies at low risk of bias, reduced heterogeneity and again suggested no significant effect of omega 3 fats. Restricting analysis to trials increasing fish-based omega 3 fats, or those increasing short chain omega 3s, did not suggest significant effects on mortality or cardiovascular events in either group. Subgroup analysis by dietary advice or supplementation, baseline risk of CVD or omega 3 dose suggested no clear effects of these factors on primary outcomes. Neither RCTs nor cohorts suggested increased relative risk of cancers with higher omega 3 intake but estimates were imprecise so a clinically important effect could not be excluded. Authors’ conclusions It is not clear that dietary or supplemental omega 3 fats alter total mortality, combined cardiovascular events or cancers in people with, or at high risk of, cardiovascular disease or in the general population. There is no evidence we should advise people to stop taking rich sources of omega 3 fats, but further high quality trials are needed to confirm suggestions of a protective effect of omega 3 fats on cardiovascular health. There is no clear evidence that omega 3 fats differ in effectiveness according to fish or plant sources, dietary or supplemental sources, dose or presence of placebo. PMID:15495044

Omega-3 fatty acids upregulate adult neurogenesis

PubMed Central

Beltz, Barbara S.; Tlusty, Michael F.; Benton, Jeannie L.; Sandeman, David C.

2007-01-01

Omega-3 fatty acids play crucial roles in the development and function of the central nervous system. These components, which must be obtained from dietary sources, have been implicated in a variety of neurodevelopmental and psychiatric disorders. Furthermore, the presence of omega-6 fatty acids may interfere with omega-3 fatty acid metabolism. The present study investigated whether changes in dietary ratios of omega-3:omega-6 fatty acids influence neurogenesis in the lobster (Homarus americanus) brain where, as in many vertebrate species, neurogenesis persists throughout life. The factors that regulate adult neurogenesis are highly conserved among species, and the crustacean brain has been successfully utilized as a model for investigating this process. In this study, lobsters were fed one of three diets that differed in fatty acid content. These animals were subsequently incubated in 5-bromo-2′-deoxyuridine (BrdU) to detect cells in S-phase of the cell cycle. A quantitative analysis of the resulting BrdU-labeled cells in the projection neuron cluster in the brain shows that short-term augmentation of dietary omega-3 relative to omega-6 fatty acids results in significant increases in the numbers of S-phase cells, and that the circadian pattern of neurogenesis is also altered. It is proposed that the ratio of omega-3:omega-6 fatty acids may alter neurogenesis via modulatory influences on membrane proteins, cytokines and/or neurotrophins. PMID:17240063

The Bloch Approximation in Periodically Perforated Media

DOE Office of Scientific and Technical Information (OSTI.GOV)

Conca, C.; Gomez, D., E-mail: gomezdel@unican.es; Lobo, M.

2005-06-15

We consider a periodically heterogeneous and perforated medium filling an open domain {omega} of R{sup N}. Assuming that the size of the periodicity of the structure and of the holes is O({epsilon}),we study the asymptotic behavior, as {epsilon} {sup {yields}} 0, of the solution of an elliptic boundary value problem with strongly oscillating coefficients posed in {omega}{sup {epsilon}}({omega}{sup {epsilon}} being {omega} minus the holes) with a Neumann condition on the boundary of the holes. We use Bloch wave decomposition to introduce an approximation of the solution in the energy norm which can be computed from the homogenized solution and themore » first Bloch eigenfunction. We first consider the case where {omega}is R{sup N} and then localize the problem for abounded domain {omega}, considering a homogeneous Dirichlet condition on the boundary of {omega}.« less

The Effect of Omega-3 Fatty Acid Supplementation on the Inflammatory Response to eccentric strength exercise.

PubMed

Jouris, Kelly B; McDaniel, Jennifer L; Weiss, Edward P

2011-01-01

Omega-3 fatty acids (omega-3) have anti-inflammatory properties. However, it is not known if omega-3 supplementation attenuates exercise-induced inflammation. We tested the hypothesis that omega-3 supplementation reduces inflammation that is induced by eccentric arm curl exercise. Healthy adult men and women (n=11; 35 ± 10 y) performed eccentric biceps curls on two occasions, once after 14d of dietary omega-3 restriction (control trial) and again after 7d of 3,000 mg/d omega-3 supplementation (omega-3 trial). Before and 48 h after eccentric exercise, signs of inflammation was assessed by measuring soreness ratings, swelling (arm circumference and arm volume), and temperature (infrared skin sensor). Arm soreness increased (p < 0.0001) in response to eccentric exercise; the magnitude of increase in soreness was 15% less in the omega-3 trial (p = 0.004). Arm circumference increased after eccentric exercise in the control trial (p = 0.01) but not in the omega-3 trial (p = 0.15). However, there was no difference between trials (p = 0.45). Arm volume and skin temperature did not change in response to eccentric exercise in either trial. These findings suggest that omega-3 supplementation decreases soreness, as a marker of inflammation, after eccentric exercise. Based on these findings, omega-3 supplementation could provide benefits by minimizing post-exercise soreness and thereby facilitate exercise training in individuals ranging from athletes undergoing heavy conditioning to sedentary subjects or patients who are starting exercise programs or medical treatments such as physical therapy or cardiac rehabilitation. Key pointsDietary supplementation with omega-3 fatty acids has been shown to reduce inflammation in numerous inflammatory diseases such as rheumatoid arthritis, inflammatory bowel disease, and Chrohn's disease.Although strenuous exercise is known to cause acute increases in inflammation, it is not clear if omega-3 fatty acid supplementation attenuates this adverse response to exercise.Our research demonstrates that 3000 mg·d-1 omega-3 fatty acid supplementation minimizes the severe, delayed-onset muscle soreness that results from strenuous eccentric strength exercise.This information, along with a plethora of information showing that omega-3 fatty acid supplementation has other health benefits, demonstrates that a readily available over the counter nutritional supplement (i.e. omega-3 fatty acids) reduces delayed-onset soreness caused by strenuous strength exercise.This information has obvious relevance to athletic populations but also to other groups such as physical therapy patients and newly admitted cardiac rehabilitation patients, as muscle soreness, if left unchecked, can slow the progress in adapting to a new exercise program.Furthermore, as inflammation is known to be involved in the pathogenesis if numerous diseases, including heart disease, cancer, and diabetes, it is likely prudent for individuals to use inflammation-attenuating interventions, such as omega-3 supplementation, to keep inflammatory responses to physical activity at a minimum.

Polyunsaturated fatty acids and calcaneal ultrasound parameters among Inuit women from Nuuk (Greenland): a longitudinal study.

PubMed

Paunescu, Alexandra-Cristina; Ayotte, Pierre; Dewailly, Eric; Dodin, Sylvie; Pedersen, Henning S; Mulvad, Gert; Côté, Suzanne

2013-01-01

The traditional diet of Inuit people comprises large amounts of fish and marine mammals that are rich in omega-3 polyunsaturated fatty acids (PUFAs). Results from in vitro studies, laboratory animal experiments and population studies suggest that omega-3 PUFA intake and a high omega-3/omega-6 ratio exert a positive effect on bone health. This longitudinal study was conducted to examine the relationship between omega-3 and omega-6 PUFA status and quantitative ultrasound (QUS) parameters in Greenlandic Inuit women. The study included 118 Inuit women from Nuuk (Greenland), aged 49-64 years, whose QUS parameters measured at baseline (year 2000), along with PUFA status and covariates, and follow-up QUS measurements 2 years later (year 2002). QUS parameters [speed of sound (SOS); broadband ultrasound attenuation (BUA)] were measured at the right calcaneus with a water-bath Lunar Achilles instrument. Omega-3 and omega-6 PUFA contents of erythrocyte membrane phospholipids were measured after transmethylation by gas chromatography coupled with a flame ionization detector. Relationships between QUS parameters and different PUFAs were studied in multiple linear regression models. Increasing values of EPA, DHA and the omega-3/omega-6 PUFA ratio were associated with increased BUA values measured at follow-up (year 2002). These associations were still present in models adjusted for several confounders and covariates. We found little evidence of associations between PUFAs and SOS values. The omega-3 PUFA intake from marine food consumption seems to have a positive effect on bone intrinsic quality and strength, as revealed by higher BUA values in this group of Greenlandic Inuit women.

Fluoxetine potentiation of omega-3 fatty acid antidepressant effect: evaluating pharmacokinetic and brain fatty acid-related aspects in rodents.

PubMed

Laino, Carlos Horacio; Garcia, Pilar; Podestá, María Fernanda; Höcht, Christian; Slobodianik, Nora; Reinés, Analía

2014-10-01

We previously reported that combined fluoxetine administration at antidepressant doses renders additive antidepressant effects, whereas non-antidepressant doses potentiate the omega-3 fatty acid antidepressant effect. In the present study, we aimed to evaluate putative pharmacokinetic and brain omega-3 fatty acid-related aspects for fluoxetine potentiation of omega-3 fatty acid antidepressant effect in rats. Coadministration of omega-3 fatty acids with a non-antidepressant dose of fluoxetine (1 mg/kg day) failed to affect both brain fluoxetine concentration and norfluoxetine plasma concentration profile. Fluoxetine plasma concentrations remained below the sensitivity limit of the detection method. Either antidepressant (10 mg/kg day) or non-antidepressant (1 mg/kg day) doses of fluoxetine in combination with omega-3 fatty acids increased hippocampal docosapentaenoic acid (DPA, 22:5 omega-3) levels. Although individual treatments had no effects on DPA concentration, DPA increase was higher when omega-3 were combined with the non-antidepressant dose of fluoxetine. Chronic DPA administration exerted antidepressant-like effects in the forced swimming test while increasing hippocampal docosahexaenoic (22:6 omega-3) and DPA levels. Our results suggest no pharmacokinetic interaction and reveal specific hippocampal DPA changes after fluoxetine and omega-3 combined treatments in our experimental conditions. The DPA role in the synergistic effect of fluoxetine and omega-3 combined treatments will be for sure the focus of future studies. © 2014 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 103:3316-3325, 2014. © 2014 Wiley Periodicals, Inc. and the American Pharmacists Association.

Lower omega-3 fatty acids are associated with the presence of anti-cyclic citrullinated peptide autoantibodies in a population at risk for future rheumatoid arthritis: a nested case-control study

PubMed Central

Gan, Ryan W.; Young, Kendra A.; Zerbe, Gary O.; Demoruelle, M. Kristen; Weisman, Michael H.; Buckner, Jane H.; Gregersen, Peter K.; Mikuls, Ted R.; O’Dell, James R.; Keating, Richard M.; Clare-Salzler, Michael J.; Deane, Kevin D.; Holers, V. Michael

2016-01-01

Objective. The aim of this study was to investigate omega-3 fatty acid (FA) supplement use and omega-3 FAs in erythrocyte membranes [omega-3 FA % in erythrocyte membranes (RBC)] and their association with anti-CCP autoantibodies in a population without RA, but who are at genetic risk for RA. Methods. The multicentre Studies of the Etiology of RA (SERA) cohort includes RA-free subjects who are first-degree relatives of RA probands or are enriched with the HLA-DR4 allele. In a nested case-control study, 30 SERA cases were identified who were anti-CCP2 antibody positive. We further identified 47 autoantibody negative controls, frequency matched to cases on age at study visit, sex, race and study site. Anti-CCP2 status, self-reported omega-3 FA supplement use and omega-3 FA % in RBCs were obtained from a single visit. Results. Anti-CCP2 positive cases were less likely than controls to report omega-3 FA supplement use (odds ratio: 0.14; 95% CI 0.03, 0.68). In addition, the likelihood of anti-CCP2 positivity was inversely associated with total omega-3 FA % in RBCs (odds ratio: 0.47; 95% CI 0.24, 0.92, for a s.d. increase). Conclusion. The inverse association between anti-CCP2 positivity and self-reported omega-3 FA supplement use and omega-3 FA % in RBCs suggests that omega-3 FAs may protect against the development of RA-related autoimmunity in pre-clinical RA. PMID:26370400

40 CFR 721.10286 - Formaldehyde, polymer with .alpha.-(2-aminomethylethyl)- .omega.-(2- aminomethylethoxy)poly[ oxy...

Code of Federal Regulations, 2014 CFR

2014-07-01

...-aminomethylethyl)- .omega.-(2- aminomethylethoxy)poly[ oxy(methyl- 1,2-ethanediyl)] and 4-(1,1-dimethylethyl)phenol... Specific Chemical Substances § 721.10286 Formaldehyde, polymer with .alpha.-(2-aminomethylethyl)- .omega... formaldehyde, polymer with .alpha.-(2- aminomethylethyl)-.omega.-(2- aminomethylethoxy)poly[oxy(methyl- 1,2...

Time to Talk: Five Things to Know about Omega-3s for Heart Disease

MedlinePlus

... X Y Z 5 Things To Know About Omega-3s for Heart Disease Share: Omega-3 fatty acids are a group of polyunsaturated fatty ... supplements. While experts agree that fish rich in omega-3 fatty acids should be included in a heart- ...

40 CFR 721.10286 - Formaldehyde, polymer with .alpha.-(2-aminomethylethyl)- .omega.-(2-aminomethylethoxy) poly[oxy...

Code of Federal Regulations, 2012 CFR

2012-07-01

...-aminomethylethyl)- .omega.-(2-aminomethylethoxy) poly[oxy(methyl-1,2-ethanediyl)] and 4-(1,1-dimethylethyl)phenol... Specific Chemical Substances § 721.10286 Formaldehyde, polymer with .alpha.-(2-aminomethylethyl)- .omega... formaldehyde, polymer with .alpha.-(2-aminomethylethyl)-.omega.-(2-aminomethylethoxy)poly[oxy(methyl-1,2...

75 FR 51382 - Alkyl Alcohol Alkoxylate Phosphate Derivatives; Exemption from the Requirement of a Tolerance

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-20

... branched, saturated and or unsaturated)-[omega]-hydroxypolyoxyethylene polymer with or without...), [alpha]-tridecyl- [omega] -hydroxy-, phosphate (9046-01-9); Poly(oxy-1 ,2-ethanediyl), [alpha]-dodecyl-[omega]-hydroxy-, phosphate (39464-66- 9); Poly(oxy-1 ,2-ethanediyl), [alpha]-hexadecyl-[omega]-hydroxy...

Substorms, poleward boundary activations and geosynchronous particle injections during sawtooth events

NASA Astrophysics Data System (ADS)

Henderson, M. G.

2006-12-01

During sawtooth events, the auroral distribution is typically comprised of an active and dynamic double oval configuration. In association with each tooth, the double oval evolves in a repeatable manner in which a wide double-oval configuration gradually thins down in association with an expansion of the polar cap and stretching of the tail field lines. This is followed by a localized substorm-like brightening of the auroral distribution in the dusk to midnight sector on the lower branch of the double oval which subsequently expands rapidly poleward and azimuthally. A new expanded double oval configuration emerges from this expansion phase activity and the cycle repeats itself for the duration of the sawtooth event. This behavior is highly consistent with the Akasofu picture of substorm onset occurring deep within the closed field-line region on the equator-most arc. Due to the large separation between the poleward boundary and the onset region during these types of substorms, the interaction between the onset region and poleward boundary intensifications, auroral streamers, inclined arcs, torches and omega bands are more easily determined. Here, we show that: (1) Sawtooth injections can be produced by the copious production of auroral streamers, without a substorm onset; (2) Auroral streamers typically evolve into torches and omega bands rather than leading to onsets; (3) Equatorward-moving "inclined arcs" can feed into the onset region. The observations might be explained by the scale-size-dependent behavior of earthward-moving depleted flux tubes in the tail. In this hypothesis, streamers can penetrate rapidly toward the earth (via interchange) and mitigate the pressure crisis in the near-earth region, while the slower-moving inclined arcs map to large-scale depleted flux tubes that do not efficiently penetrate earthward and hence do not alleviate the pressure crisis in the pre-midnight sector.

All-Sky Observational Evidence for An Inverse Correlation Between Dust Temperature and Emissivity Spectral Index

NASA Technical Reports Server (NTRS)

Liang, Z.; Fixsen, D. J.; Gold, B.

2012-01-01

We show that a one-component variable-emissivity-spectral-index model (the free- model) provides more physically motivated estimates of dust temperature at the Galactic polar caps than one- or two-component fixed-emissivity-spectral-index models (fixed- models) for interstellar dust thermal emission at far-infrared and millimeter wavelengths. For the comparison we have fit all-sky one-component dust models with fixed or variable emissivity spectral index to a new and improved version of the 210-channel dust spectra from the COBE-FIRAS, the 100-240 micrometer maps from the COBE-DIRBE and the 94 GHz dust map from the WMAP. The best model, the free-alpha model, is well constrained by data at 60-3000 GHz over 86 per cent of the total sky area. It predicts dust temperature (T(sub dust)) to be 13.7-22.7 (plus or minus 1.3) K, the emissivity spectral index (alpha) to be 1.2-3.1 (plus or minus 0.3) and the optical depth (tau) to range 0.6-46 x 10(exp -5) with a 23 per cent uncertainty. Using these estimates, we present all-sky evidence for an inverse correlation between the emissivity spectral index and dust temperature, which fits the relation alpha = 1/(delta + omega (raised dot) T(sub dust) with delta = -.0.510 plus or minus 0.011 and omega = 0.059 plus or minus 0.001. This best model will be useful to cosmic microwave background experiments for removing foreground dust contamination and it can serve as an all-sky extended-frequency reference for future higher resolution dust models.

Lunar and Planetary Science XXXVI, Part 6

NASA Technical Reports Server (NTRS)

2005-01-01

Contents include the following: A Model for Multiple Populations of Presolar Diamonds. Characterization of Martian North Polar Geologic Units Using Mars Odyssey THEMIS Data. Effect of Flow on the Internal Structure of the Martian North Polar Layered Deposits. Elemental Abundance Distributions in Basalt Clays and Meteorites: Is It a Biosignature? Early Results on the Saturn System from the Composite Infrared Spectrometer. NanoSIMS D/H Imaging of Isotopically Primitive Interplanetary Dust Particles. Presolar (Circumstellar and Interstellar) Phases in Renazzo: The Effects of Parent Body Processing. Catastrophic Disruption of Hydrated Targets: Implications for the Hydrated Asteroids and for the Production of Interplanetary Dust Particles. Chemical and Mineralogical Analyses of Particles from the Stratospheric Collections Coinciding with the 2002 Leonid Storm and the 2003 Comet Grigg-Skjellerup Trail Passage. An Analysis of the Solvus in the CaS-MnS System. ESA s SMART-1 Mission at the Moon: First Results, Status and Next Steps. Europa Analog Ice-splitting Measurements and Experiments with Ice-Hunveyor on the Frozen Balaton-Lake, Hungary. Chromium on Eros: Further Evidence of Ordinary Chondrite Composition. Dust Devil Tracks on Mars: Observation and Analysis from Orbit and the Surface. Spatial Variation of Methane and Other Trace Gases Detected on Mars: Interpretation with a General Circulation Model. Mars Water Ice and Carbon Dioxide Seasonal Polar Caps: GCM Modeling and Comparison with Mars Express Omega Observations. Component Separation of OMEGA Spectra with ICA. Clathrate Formation in the Near-Surface Environment of Titan. Space Weathering: A Proposed Laboratory Approach to Explaining the Sulfur Depletion on Eros. Sample Collection from Small Airless Bodies: Examination of Temperature Constraints for the TGIP. Sample Collector for the Hera Near-Earth Asteroid Sample Return Mission. A Rugged Miniature Mass-Spectrometer for Measuring Aqueous Geochemistry on Mars. Martian and Lunar Pyroxene Microstructures Studied by Single-Crystal X-Ray Diffraction.

Lunar and Planetary Science XXXVI, Part 12

NASA Technical Reports Server (NTRS)

2005-01-01

Topics discussed include: The Ancient Lakes in Hellas Basin Region as Seen Through the First Year of Mars Express HRSC-Camera; DISR Observations of Craters at Titan at the Huygens Landing Site: Insights Anticipated; The Sun s Dust Disk - Discovery Potential of the New Horizons Mission During Interplanetary Cruise; Evidence for Aqueously Precipitated Sulfates in Northeast Meridiani Using THEMIS and TES Data; Integrated Spectroscopic Studies of Anhydrous Sulfate Minerals; Venusian Channel Formation as a Subsurface Process; Reexamination of Quartz Grains from the Permian-Triassic Boundary Section at Graphite Peak, Antarctica; Observations of Calcium Sulfate Deposits at High Latitudes by OMEGA/Mex at Km/Pixel Resolutions; Observations of the North Permanent Cap of Mars in Mid-Summer by OMEGA/MEX at km per Pixel Resolutions; Classification and Distribution of Patterned Ground in the Southern Hemisphere of Mars Genesis: Removing Contamination from Sample Collectors; Thermal Characterization of Fe3O4 Nanoparticles Formed from Poorly Crystalline Siderite; Hydrogen Abundances in Metal Grains from the Hammadah Al Hamra (HaH) 237 Metal-rich Chondrite: A Test of the Nebular-Formation Theory; REE and Some Other Trace Elements Distributions of Mineral Separates in Atlanta (EL6); The Composition and Origin of the Dewar Geochemical Anomaly; Asteroid Modal Mineralogy Using Hapke Mixing Models: Testing the Utility of Spectral Lookup Tables; and The Huygens Mission at Titan: Results Highlights. (sup 182)Hf-(sup 182)W Chronometry and an Early Differentiation in the Parent Body of Ureilites Ground Penetrating Radar in Sedimentary Rocks Mars, Always Cold, Sometimes Wet: New Constraints on Mars Denudation Rates and Climate Evolution from Analog Studies at Haughton Crater, Devon Island, High Arctic Europa s Porous Ice Rheology and Implications for Ice-penetrating Radar Scattering Loss Surface Generated Cracks on Europa

Section Editors

NASA Astrophysics Data System (ADS)

Groep, D. L.; Bonacorsi, D.

2014-06-01

1. Data Acquisition, Trigger and Controls Niko NeufeldCERNniko.neufeld@cern.ch Tassos BeliasDemokritosbelias@inp.demokritos.gr Andrew NormanFNALanorman@fnal.gov Vivian O'DellFNALodell@fnal.gov 2. Event Processing, Simulation and Analysis Rolf SeusterTRIUMFseuster@cern.ch Florian UhligGSIf.uhlig@gsi.de Lorenzo MonetaCERNLorenzo.Moneta@cern.ch Pete ElmerPrincetonpeter.elmer@cern.ch 3. Distributed Processing and Data Handling Nurcan OzturkU Texas Arlingtonnurcan@uta.edu Stefan RoiserCERNstefan.roiser@cern.ch Robert IllingworthFNAL Davide SalomoniINFN CNAFDavide.Salomoni@cnaf.infn.it Jeff TemplonNikheftemplon@nikhef.nl 4. Data Stores, Data Bases, and Storage Systems David LangeLLNLlange6@llnl.gov Wahid BhimjiU Edinburghwbhimji@staffmail.ed.ac.uk Dario BarberisGenovaDario.Barberis@cern.ch Patrick FuhrmannDESYpatrick.fuhrmann@desy.de Igor MandrichenkoFNALivm@fnal.gov Mark van de SandenSURF SARA sanden@sara.nl 5. Software Engineering, Parallelism & Multi-Core Solveig AlbrandLPSC/IN2P3solveig.albrand@lpsc.in2p3.fr Francesco GiacominiINFN CNAFfrancesco.giacomini@cnaf.infn.it Liz SextonFNALsexton@fnal.gov Benedikt HegnerCERNbenedikt.hegner@cern.ch Simon PattonLBNLSJPatton@lbl.gov Jim KowalkowskiFNAL jbk@fnal.gov 6. Facilities, Infrastructures, Networking and Collaborative Tools Maria GironeCERNMaria.Girone@cern.ch Ian CollierSTFC RALian.collier@stfc.ac.uk Burt HolzmanFNALburt@fnal.gov Brian Bockelman U Nebraskabbockelm@cse.unl.edu Alessandro de SalvoRoma 1Alessandro.DeSalvo@ROMA1.INFN.IT Helge MeinhardCERN Helge.Meinhard@cern.ch Ray PasetesFNAL rayp@fnal.gov Steven GoldfarbU Michigan Steven.Goldfarb@cern.ch

Omega Design and FEA Based Coriolis Mass Flow Sensor (CMFS) Analysis Using Titanium Material

NASA Astrophysics Data System (ADS)

Patil, Pravin P.; Kumar, Ashwani; Ahmad, Faraz

2018-02-01

The main highlight of this research work is evaluation of resonant frequency for titanium omega type coriolis mass flow sensor. Coriolis mass flow sensor is used for measuring direct mass flow in pipe useful for various industrial applications. It works on the principle of Coriolis effect. Finite Element Analysis (FEA) simulation of omega flow sensor was performed using Ansys 14.5 and Solid Edge, Pro-E was used for modelling of omega tube. Titanium was selected as omega tube material. Experimental setup was prepared for omega tube coriolis flow sensor for performing different test. Experimental setup was used for investigation of different parameters effect on CMFS and validation of simulation results.

Does Supplementation with Omega-3 PUFAs Add to the Prevention of Cardiovascular Disease?

PubMed

Rizos, Evangelos C; Elisaf, Moses S

2017-06-01

Omega-3 fatty acids are increasingly used for the protection of cardiovascular disease. The main but not the sole mechanism of action is the reduction of triglyceride levels. In this review, we summarize the effect of omega-3 supplements on all-cause and cardiovascular mortality, myocardial infarction, and stroke from the relevant randomized controlled trials. Twenty-one randomized controlled trials assessed omega-3 supplementation on mortality and cardiovascular-related outcomes. From these studies, as well as from the relevant meta-analyses, we found that omega-3 supplements do not exert a consistent benefit for cardiovascular protection. There is uncertainty of a clear profit from omega-3 supplementation in cardiovascular disease.

FY14 LLNL OMEGA Experimental Programs

DOE Office of Scientific and Technical Information (OSTI.GOV)

Heeter, R. F.; Fournier, K. B.; Baker, K.

In FY14, LLNL’s High-Energy-Density Physics (HED) and Indirect Drive Inertial Confinement Fusion (ICF-ID) programs conducted several campaigns on the OMEGA laser system and on the EP laser system, as well as campaigns that used the OMEGA and EP beams jointly. Overall these LLNL programs led 324 target shots in FY14, with 246 shots using just the OMEGA laser system, 62 shots using just the EP laser system, and 16 Joint shots using Omega and EP together. Approximately 31% of the total number of shots (62 OMEGA shots, 42 EP shots) shots supported the Indirect Drive Inertial Confinement Fusion Campaign (ICF-ID).more » The remaining 69% (200 OMEGA shots and 36 EP shots, including the 16 Joint shots) were dedicated to experiments for High- Energy-Density Physics (HED). Highlights of the various HED and ICF campaigns are summarized in the following reports.« less

Angular Momentum Transport in Turbulent Flow between Independently Rotating Cylinders

DOE Office of Scientific and Technical Information (OSTI.GOV)

Paoletti, M. S.; Lathrop, D. P.; Institute for Physical Science and Technology, University of Maryland, College Park, Maryland 20742

2011-01-14

We present measurements of the angular momentum flux (torque) in Taylor-Couette flow of water between independently rotating cylinders for all regions of the ({Omega}{sub 1}, {Omega}{sub 2}) parameter space at high Reynolds numbers, where {Omega}{sub 1} ({Omega}{sub 2}) is the inner (outer) cylinder angular velocity. We find that the Rossby number Ro=({Omega}{sub 1}-{Omega}{sub 2})/{Omega}{sub 2} fully determines the state and torque G as compared to G(Ro={infinity}){identical_to}G{sub {infinity}.} The ratio G/G{sub {infinity}} is a linear function of Ro{sup -1} in four sections of the parameter space. For flows with radially increasing angular momentum, our measured torques greatly exceed those of previousmore » experiments [Ji et al., Nature (London), 444, 343 (2006)], but agree with the analysis of Richard and Zahn [Astron. Astrophys. 347, 734 (1999)].« less

FY15 LLNL OMEGA Experimental Programs

DOE Office of Scientific and Technical Information (OSTI.GOV)

Heeter, R. F.; Baker, K. L.; Barrios, M. A.

In FY15, LLNL’s High-Energy-Density Physics (HED) and Indirect Drive Inertial Confinement Fusion (ICF-ID) programs conducted several campaigns on the OMEGA laser system and on the EP laser system, as well as campaigns that used the OMEGA and EP beams jointly. Overall these LLNL programs led 468 target shots in FY15, with 315 shots using just the OMEGA laser system, 145 shots using just the EP laser system, and 8 Joint shots using Omega and EP together. Approximately 25% of the total number of shots (56 OMEGA shots and 67 EP shots, including the 8 Joint shots) supported the Indirect Drivemore » Inertial Confinement Fusion Campaign (ICF-ID). The remaining 75% (267 OMEGA shots and 86 EP shots) were dedicated to experiments for High-Energy-Density Physics (HED). Highlights of the various HED and ICF campaigns are summarized in the following reports.« less

Antioxidant activity of sesamol and omega-oryzanol towards fish oil

USDA-ARS?s Scientific Manuscript database

Two natural antioxidants, sesamol and omega-oryzanol, were examined for their antioxidant activity towards omega-3 oil. Sesamol and omega-oryzanol have been known to provide antioxidant effects at high temperatures such as those used for frying. In this study, the effects of 0.84 mM and 8.4 mM oryza...

40 CFR 721.10398 - Poly(oxy-1,2-ethanediyl),. alpha., -monoalkyl ethers-.omega.-mono (hydrogen maleate)- (generic).

Code of Federal Regulations, 2014 CFR

2014-07-01

...., -monoalkyl ethers-.omega.-mono (hydrogen maleate)- (generic). 721.10398 Section 721.10398 Protection of...-ethanediyl),. alpha., -monoalkyl ethers-.omega.-mono (hydrogen maleate)- (generic). (a) Chemical substance... poly(oxy-1,2-ethanediyl), .alpha., -monoalkyl ethers-.omega.-mono (hydrogen maleate)- (PMN P-10-495) is...

40 CFR 721.10398 - Poly(oxy-1,2-ethanediyl),. alpha., -monoalkyl ethers-.omega.-mono (hydrogen maleate)- (generic).

Code of Federal Regulations, 2013 CFR

2013-07-01

...., -monoalkyl ethers-.omega.-mono (hydrogen maleate)- (generic). 721.10398 Section 721.10398 Protection of...-ethanediyl),. alpha., -monoalkyl ethers-.omega.-mono (hydrogen maleate)- (generic). (a) Chemical substance... poly(oxy-1,2-ethanediyl), .alpha., -monoalkyl ethers-.omega.-mono (hydrogen maleate)- (PMN P-10-495) is...

40 CFR 721.10398 - Poly(oxy-1,2-ethanediyl),. alpha., -monoalkyl ethers-.omega.-mono (hydrogen maleate)- (generic).

Code of Federal Regulations, 2012 CFR

2012-07-01

...., -monoalkyl ethers-.omega.-mono (hydrogen maleate)- (generic). 721.10398 Section 721.10398 Protection of...-ethanediyl),. alpha., -monoalkyl ethers-.omega.-mono (hydrogen maleate)- (generic). (a) Chemical substance... poly(oxy-1,2-ethanediyl), .alpha., -monoalkyl ethers-.omega.-mono (hydrogen maleate)- (PMN P-10-495) is...

40 CFR 721.10355 - Poly[oxy-1,2-ethanediyl), .alpha.-(1-oxododecyl)-.omega.-[3-triethoxysilyl)propoxy]-.

Code of Federal Regulations, 2014 CFR

2014-07-01

...-oxododecyl)-.omega.-[3-triethoxysilyl)propoxy]-. 721.10355 Section 721.10355 Protection of Environment....-(1-oxododecyl)-.omega.-[3-triethoxysilyl)propoxy]-. (a) Chemical substance and significant new uses...-oxododecyl)-.omega.-[3-triethoxysilyl)propoxy]- (PMN P-08-722; CAS No. 1041420-54-5) is subject to reporting...

40 CFR 721.10355 - Poly[oxy-1,2-ethanediyl), .alpha.-(1-oxododecyl)-.omega.-[3-triethoxysilyl)propoxy]-.

Code of Federal Regulations, 2012 CFR

2012-07-01

...-oxododecyl)-.omega.-[3-triethoxysilyl)propoxy]-. 721.10355 Section 721.10355 Protection of Environment....-(1-oxododecyl)-.omega.-[3-triethoxysilyl)propoxy]-. (a) Chemical substance and significant new uses...-oxododecyl)-.omega.-[3-triethoxysilyl)propoxy]- (PMN P-08-722; CAS No. 1041420-54-5) is subject to reporting...

40 CFR 721.10355 - Poly[oxy-1,2-ethanediyl), .alpha.-(1-oxododecyl)-.omega.-[3-triethoxysilyl)propoxy]-.

Code of Federal Regulations, 2013 CFR

2013-07-01

...-oxododecyl)-.omega.-[3-triethoxysilyl)propoxy]-. 721.10355 Section 721.10355 Protection of Environment....-(1-oxododecyl)-.omega.-[3-triethoxysilyl)propoxy]-. (a) Chemical substance and significant new uses...-oxododecyl)-.omega.-[3-triethoxysilyl)propoxy]- (PMN P-08-722; CAS No. 1041420-54-5) is subject to reporting...

Stability of omega-3 fatty acids in fortified surimi seafoods during chilled storage.

PubMed

Pérez-Mateos, Miriam; Boyd, Leon; Lanier, Tyre

2004-12-29

Physical, chemical, and sensory properties of cooked surimi seafood gels (crab analogue) fortified with omega-3 fatty acids (FA) were monitored during chilled storage. Three sources of stabilized omega-3 FA (fish oil concentrate, menhaden oil, and a purified marine oil) were each incorporated into gels to an omega-3 FA content of 1.5 or 2.5%, w/w. Omega-3 FA stability, development of off-flavors, and changes in color and texture were monitored during chilled storage for 2 months. Gels with fish oil concentrate developed fishy flavor and aroma within 30 days and were eliminated from the study. Gels containing menhaden oil and purified marine oil exhibited little change in sensory properties or oxidation products throughout 2 months of storage. Relative polyene index values (ratio of polyunsaturated to saturated fatty acids) indicated that the omega-3 FA were stable at both levels of addition. Omega-3 fortified gels were whiter than control gels, and gel texture was modified when menhaden and purified oils were added but not significantly affected by the level of omega-3 addition.

Laboratory discharge studies of a 6 V alkaline lantern-type battery Eveready Energizer no. 528, under various ambient temperatures (-15 deg C and + 22 deg C) and loads (30 omega and 60 omega)

NASA Technical Reports Server (NTRS)

Ahrens, S. T.

1984-01-01

The voltages of two Eveready No. 528 batteries, one the test battery, the other the control battery, were simultaneously recorded as they were discharged across 30 omega loads using a dual chart recorder. The test battery was initially put in a freezer at -15 + or - 3 C. After its voltage had fallen to .6 V, it was brought back out into the room at 22 + or - 3 C. A second run was made with 60 omega loads. Assuming a 3.0 V cut-off, the total energy output of the test battery at -15 C was 26 WHr 30 omega and 35 WHr 60 omega, and the corresponding numbers for the control battery at 22 C were 91 WHr and 100 WHr. When the test battery was subsequently allowed to warm up, the voltage rose above 4 V and the total energy output rose to 80 WHr 30 omega and 82 WHR 60 omega.

Conducting omega-3 clinical trials with cardiovascular outcomes: Proceedings of a workshop held at ISSFAL 2014.

PubMed

Rice, Harry B; Bernasconi, Aldo; Maki, Kevin C; Harris, William S; von Schacky, Clemens; Calder, Philip C

2016-04-01

In contrast to earlier long-chain (LC) omega-3 (i.e. EPA and DHA) investigations, some recent studies have not demonstrated significant effects of EPA and DHA on cardiovascular disease (CVD) outcomes. The neutral findings may have been due to experimental design issues, such as: maintenance on aggressive cardiovascular drug treatment overshadowing the benefits of LC omega-3s, high background LC omega-3 intake, too few subjects in the study, treatment duration too short, insufficient LC omega-3 dosage, increase in omega-6 fatty acid intake during the study, failure to assess the LC omega-3 status of the subjects prior to and during treatment and lack of clarity concerning which mechanisms were expected to produce benefits. At the 11th ISSFAL Congress, a workshop was held on conducting LC omega-3 clinical trials with cardiovascular outcomes, with the goal of gaining a better understanding concerning aspects of experimental design that should be considered when planning clinical studies related to EPA and DHA and potential cardiovascular benefits. Copyright © 2016 The Authors. Published by Elsevier Ltd.. All rights reserved.

The Role of Omega-3 Fatty Acids in Diets.

PubMed

Gomez-Candela, C; Roldan Puchalt, M C; Palma Milla, S; Lopez Plaza, B; Bermejo, L

2015-01-01

The article is a summary of Dra. Carmen Gómez Candela's presentation at the Science in Nutrition 3rd International Congress in Milan, March 2014. The article covers omega-3 fatty acids use in different medical areas and several institutions' opinions in relation to the topic. Omega-3 acids are essential fatty acids. A certain amount of omega-3 is needed in our daily diet; however, the usual consumption is generally less than the recommended amount. Changes in dietary patterns in the course of history have led to deficit levels of omega-3 in the human body. Currently, there is increasing evidence of the benefits of omega-3 in different medical specialities. There are still some gaps regarding its role in illnesses such as dementia, psychiatric disorders, and inflammatory diseases. Nevertheless, stronger evidence is being proved in cardiovascular diseases and cancer. This article provides a reflection on possible ways to increase omega-3 daily consumption and the constraints associated with food with high contents of heavy metals, which, in turn, are also rich in omega-3s.

Omega-3 and Omega-6 Fatty Acids Act as Inhibitors of the Matrix Metalloproteinase-2 and Matrix Metalloproteinase-9 Activity.

PubMed

Nicolai, Eleonora; Sinibaldi, Federica; Sannino, Gianpaolo; Laganà, Giuseppina; Basoli, Francesco; Licoccia, Silvia; Cozza, Paola; Santucci, Roberto; Piro, Maria Cristina

2017-08-01

Polyunsaturated fatty acids have been reported to play a protective role in a wide range of diseases characterized by an increased metalloproteinases (MMPs) activity. The recent finding that omega-3 and omega-6 fatty acids exert an anti-inflammatory effect in periodontal diseases has stimulated the present study, designed to determine whether such properties derive from a direct inhibitory action of these compounds on the activity of MMPs. To this issue, we investigated the effect exerted by omega-3 and omega-6 fatty acids on the activity of MMP-2 and MMP-9, two enzymes that actively participate to the destruction of the organic matrix of dentin following demineralization operated by bacteria acids. Data obtained (both in vitro and on ex-vivo teeth) reveal that omega-3 and omega-6 fatty acids inhibit the proteolytic activity of MMP-2 and MMP-9, two enzymes present in dentin. This observation is of interest since it assigns to these compounds a key role as MMPs inhibitors, and stimulates further study to better define their therapeutic potentialities in carious decay.

Diet fat alters synaptosomal phosphatidylethanolaminemethyl-transferase activity and phosphatidylcholine synthesis in brain

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hargreaves, K.M.; Clandinin, M.T.

1986-03-05

Phosphatidylcholine (PC) can be synthesized via three routes, each having potentially different metabolic fates. One route for PC synthesis is methylation of phosphatidylethanolamine (PE). To examine if dietary fat affects membrane PE composition and phosphatidylethanolaminemethyltransferase (PEMT) activity, male weanling rats were fed semi-purified diets containing 20% (w/w) fat of differing fatty acid composition for 24 days. Microsomal and synaptic plasma membranes were isolated and phospholipid composition analyzed. PEMT activity was measured by incorporation of the methyl group from /sup 3/H-S-adenosylmethionine into PE. Polyunsaturated diets high in omega 6 fatty acids produce a high ratio of omega 6/omega 3 fatty acidsmore » in synaptic plasma membranes. Dietary omega 3 and omega 6 fatty acid levels are reflected in membrane phospholipid content of 22:6(3), 20:4(6), 22:4(6) and 22:5(6). Diet-induced increase in these longer chain homologues of omega 6 and omega 3 fatty acids and a high ratio of omega 6/omega 3 fatty acids in PE are both associated with increased PEMT activity. These results suggest that diet-fat induced change in fatty acid composition of membrane PE results in transition in PEMT activity and synthesis of PC in brain, by providing preferred species of PE for methylation.« less

Anti-inflammatory effects of omega 3 and omega 6 polyunsaturated fatty acids in cardiovascular disease and metabolic syndrome.

PubMed

Tortosa-Caparrós, Esther; Navas-Carrillo, Diana; Marín, Francisco; Orenes-Piñero, Esteban

2017-11-02

A lipid excess produces a systemic inflammation process due to tumor necrosis factor-α, interleukin-6 and C-reactive protein synthesis. Simultaneously, this fat excess promotes the appearance of insulin resistance. All this contributes to the development of atherosclerosis and increases the risk of cardiovascular diseases (CVDs). On the other hand, polyunsaturated fatty acids (PUFAs), especially eicosapentaenoic acid and docosahexaenoic acid (omega 3), and arachidonic acid (omega 6) have shown anti-inflammatory properties. Lately, an inverse relationship between omega-3 fatty acids, inflammation, obesity and CVDs has been demonstrated. To check fatty acids effect, the levels of some inflammation biomarkers have been analyzed. Leptin, adiponectin and resistin represent a group of hormones associated with the development of CVDs, obesity, type 2 diabetes mellitus and insulin resistance and are modified in obese/overweight people comparing to normal weight people. Omega-3 PUFAs have been shown to decrease the production of inflammatory mediators, having a positive effect in obesity and diabetes mellitus type-2. Moreover, they significantly decrease the appearance of CVD risk factors. Regarding omega-6 PUFA, there is controversy whether their effects are pro- or anti-inflammatory. The aim of this manuscript is to provide a comprehensive overview about the role of omega-3 and omega-6 PUFAs in CVDs and metabolic syndrome.

An Improvement of Cardiovascular Risk Factors by Omega-3 Polyunsaturated Fatty Acids.

PubMed

Yanai, Hidekatsu; Masui, Yoshinori; Katsuyama, Hisayuki; Adachi, Hiroki; Kawaguchi, Akiko; Hakoshima, Mariko; Waragai, Yoko; Harigae, Tadanao; Sako, Akahito

2018-04-01

An epidemiological survey in the Northwest Greenland reported that the Greenlanders have a lower frequency of acute myocardial infarction and diabetes mellitus. The very low incidence of ischemic heart disease in the Greenlanders was explained by consumption of a diet rich in omega-3 polyunsaturated fatty acids (PUFAs). Possible anti-atherothrombotic effects of omega-3 PUFA include an improvement of lipid metabolism such as a reduction of triglyceride and an increase of high-density lipoprotein-cholesterol (HDL-C), and glucose metabolism, anti-platelet activity, anti-inflammatory effects, an improvement of endothelial function and stabilization of atherosclerotic plaque. The present study reviews an improvement of cardiovascular risk factors such as dyslipidemia and diabetes due to consumption of omega-3 PUFA. A sufficient number of studies suggest that omega-3 PUFA supplementation reduces serum triglyceride and increases HDL-cholesterol. The mechanisms for omega-3 PUFA-mediated improvements of lipid metabolism have been partially elucidated. The studies using experimental animals, part of trials in humans, have shown the beneficial effects of omega-3 PUFA on glucose metabolism and insulin sensitivity. The meta-analysis showed that omega-3 PUFA might prevent development of diabetes in part of population. Further studies should be performed to elucidate the association of omega-3 PUFA supplementation with diabetes, in the future.

Marine omega-3 fatty acids and mood disorders--linking the sea and the soul. 'Food for Thought' I.

PubMed

Hegarty, B D; Parker, G B

2011-07-01

While there has long been interest in any nutritional contribution to the onset and treatment of mood disorders, there has been increasing scientific evaluation of several candidate nutritional and dietary factors in recent years. In this inaugural study of our 'Food for Thought' series, we will overview the evidence for any role of omega-3 fatty acids (FA) in regulating mood. Relevant literature was identified through online database searches and cross-referencing. Plausible mechanisms exist by which omega-3 FA may influence neuronal function and mood. Cross-sectional studies demonstrate an association between omega-3 fatty acid deficiency and both depressive and bipolar disorders. Studies investigating the efficacy of omega-3 fatty acid supplementation for mood disorders have however provided inconsistent results. The proportion of treatment studies showing a significant advantage of omega-3 supplementation has dropped over the last 5 years. However, the vast heterogeneity of the trials in terms of constituent omega-3 FAs, dose and length of treatment makes comparisons of these studies difficult. More research is required before omega-3 supplementation can be firmly recommended as an effective treatment for mood disorders. Whereas increased omega-3 FA intake may alleviate depressive symptoms, there is little evidence of any benefit for mania. © 2011 John Wiley & Sons A/S.

Apparatus and method for closed-loop control of reactor power in minimum time

DOEpatents

Bernard, Jr., John A.

1988-11-01

Closed-loop control law for altering the power level of nuclear reactors in a safe manner and without overshoot and in minimum time. Apparatus is provided for moving a fast-acting control element such as a control rod or a control drum for altering the nuclear reactor power level. A computer computes at short time intervals either the function: .rho.=(.beta.-.rho.).omega.-.lambda..sub.e '.rho.-.SIGMA..beta..sub.i (.lambda..sub.i -.lambda..sub.e ')+l* .omega.+l* [.omega..sup.2 +.lambda..sub.e '.omega.] or the function: .rho.=(.beta.-.rho.).omega.-.lambda..sub.e .rho.-(.lambda..sub.e /.lambda..sub.e)(.beta.-.rho.)+l* .omega.+l* [.omega..sup.2 +.lambda..sub.e .omega.-(.lambda..sub.e /.lambda..sub.e).omega.] These functions each specify the rate of change of reactivity that is necessary to achieve a specified rate of change of reactor power. The direction and speed of motion of the control element is altered so as to provide the rate of reactivity change calculated using either or both of these functions thereby resulting in the attainment of a new power level without overshoot and in minimum time. These functions are computed at intervals of approximately 0.01-1.0 seconds depending on the specific application.

Statistical study of auroral omega bands

NASA Astrophysics Data System (ADS)

Partamies, Noora; Weygand, James M.; Juusola, Liisa

2017-09-01

The presence of very few statistical studies on auroral omega bands motivated us to test-use a semi-automatic method for identifying large-scale undulations of the diffuse aurora boundary and to investigate their occurrence. Five identical all-sky cameras with overlapping fields of view provided data for 438 auroral omega-like structures over Fennoscandian Lapland from 1996 to 2007. The results from this set of omega band events agree remarkably well with previous observations of omega band occurrence in magnetic local time (MLT), lifetime, location between the region 1 and 2 field-aligned currents, as well as current density estimates. The average peak emission height of omega forms corresponds to the estimated precipitation energies of a few keV, which experienced no significant change during the events. Analysis of both local and global magnetic indices demonstrates that omega bands are observed during substorm expansion and recovery phases that are more intense than average substorm expansion and recovery phases in the same region. The omega occurrence with respect to the substorm expansion and recovery phases is in a very good agreement with an earlier observed distribution of fast earthward flows in the plasma sheet during expansion and recovery phases. These findings support the theory that omegas are produced by fast earthward flows and auroral streamers, despite the rarity of good conjugate observations.

Study of the Rare Hyperon Decay $${\\boldmath \\Omega^\\mp \\to \\Xi^\\mp \\: \\pi^+\\pi^-}$$

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kamaev, O.; Solomey, N.; Burnstein, R.A.

The authors report a new measurement of the decay {Omega}{sup -} {yields} {Xi}{sup -} {pi}{sup +}{pi}{sup -} with 76 events and a first observation of the decay {bar {Omega}}{sup +} {yields} {bar {Xi}}{sup +} {pi}{sup +}{pi}{sup -} with 24 events, yielding a combined branching ratio (3.74{sub -0.56}{sup +0.67}) x 10{sup -4}. This represents a factor 25 increase in statistics over the best previous measurement. No evidence is seen for CP violation, with {Beta}({Omega}{sup -} {yields} {Xi}{sup -} {pi}{sup +}{pi}{sup -}) = 4.04{sub -0.71}{sup +0.83} x 10{sup -4} and {Beta}({bar {Omega}}{sup +} {yields} {bar {Xi}}{sup +} {pi}{sup +}{pi}{sup -}) = 3.15{submore » -0.89}{sup +1.12} x 10{sup -4}. Contrary to theoretical expectation, they see little evidence for the decays {Omega}{sup -} {yields} {Xi}*{sub 1530}{sup 0} {pi}{sup -} and {bar {Omega}}{sup +} {yields} {bar {Xi}}*{sub 1530}{sup 0} {pi}{sup +} and place a 90% C.L. upper limit on the combined branching ratio {Beta}({Omega}{sup -}({bar {Omega}}{sup +}) {yields} {Xi}*{sub 1530}{sup 0} ({bar {Xi}}*{sub 1530}{sup 0}){pi}{sup {-+}}) < 7.0 x 10{sup -5}.« less

FY16 LLNL Omega Experimental Programs

DOE Office of Scientific and Technical Information (OSTI.GOV)

Heeter, R. F.; Ali, S. J.; Benstead, J.

In FY16, LLNL’s High-Energy-Density Physics (HED) and Indirect Drive Inertial Confinement Fusion (ICF-ID) programs conducted several campaigns on the OMEGA laser system and on the EP laser system, as well as campaigns that used the OMEGA and EP beams jointly. Overall, these LLNL programs led 430 target shots in FY16, with 304 shots using just the OMEGA laser system, and 126 shots using just the EP laser system. Approximately 21% of the total number of shots (77 OMEGA shots and 14 EP shots) supported the Indirect Drive Inertial Confinement Fusion Campaign (ICF-ID). The remaining 79% (227 OMEGA shots and 112more » EP shots) were dedicated to experiments for High-Energy-Density Physics (HED). Highlights of the various HED and ICF campaigns are summarized in the following reports. In addition to these experiments, LLNL Principal Investigators led a variety of Laboratory Basic Science campaigns using OMEGA and EP, including 81 target shots using just OMEGA and 42 shots using just EP. The highlights of these are also summarized, following the ICF and HED campaigns. Overall, LLNL PIs led a total of 553 shots at LLE in FY 2016. In addition, LLNL PIs also supported 57 NLUF shots on Omega and 31 NLUF shots on EP, in collaboration with the academic community.« less

The investigation of the prenatal and postnatal alcohol exposure-induced neurodegeneration in rat brain: protection by betaine and/or omega-3.

PubMed

Kusat Ol, Kevser; Kanbak, Güngör; Oğlakcı Ilhan, Ayşegül; Burukoglu, Dilek; Yücel, Ferruh

2016-03-01

We aim to study the effect of neurodegeneration on the brain of rat pups caused by prenatal and postnatal ethanol exposure with modified liquid diet to elucidate protective effects of betaine and omega-3 supplementation. When ethanol is consumed during prenatal and postnatal periods, it may result in fetal alcohol syndrome (FAS) in the offspring. Rats were divided into control, ethanol, ethanol + betaine, ethanol + omega-3, ethanol + omega-3 + betaine groups. The effect of betaine and omega-3 in response to ethanol-induced changes on the brain, by biochemical analyses cytochrome c, caspase-3, calpain, cathepsin B and L, DNA fragmentation, histological and morfometric methods were evaluated. Caspase-3, calpain, cathepsin B, and cytochrome c levels in ethanol group were significantly higher than control. Caspase-3, calpain levels were decreased in ethanol + betaine, ethanol + omega-3, and ethanol + omega-3 + betaine groups compared to ethanol group. Cathepsin B in ethanol + omega-3 + betaine group was decreased compared to ethanol, ethanol + betaine groups. Cathepsin L and DNA fragmentation were found not statistically significant. We found similar results in histological and morfometric parameters. We found that pre- and postnatal ethanol exposure is capable of triggering necrotic cell death in rat brains, omega-3, and betaine reduce neurodegeneration. Omega-3 and betaine may prove beneficial for neurodegeneration, particularly in preventing FAS.

Effects of omega-3 fatty acid supplementation on neurocognitive functioning and mood in deployed U.S. soldiers: a pilot study.

PubMed

Dretsch, Michael N; Johnston, Daniel; Bradley, Ryan S; MacRae, Holden; Deuster, Patricia A; Harris, William S

2014-04-01

Omega-3 fatty acids (FAs) may have neuroprotective properties for psychological health and cognition. The objective of this study was to evaluate the effectiveness of omega-3 FAs (eicosapentaenoic + docosahexaenoic; Harris-Schacky [HS]-Omega-3 Index) on neuropsychological functioning among U.S. Soldiers deployed to Iraq. This randomized, double-blind, placebo-controlled trial included Soldiers between the ages of 18 and 55 years who were randomly assigned to either the active treatment group (n = 44) or placebo group (n = 34). Active treatment was 2.5 g per day of eicosapentaenoic + docosahexaenoic (Lovaza; GlaxoSmithKline, Research Triangle Park, North Carolina). The placebo was corn oil ethyl esters. HS-Omega-3 Index, a neurocognitive battery (Central Nervous System-Vital Signs, Morrisville, North Carolina), and psychological health scales were assessed at baseline and after 60 days of treatment. Although the results revealed that omega-3 FAs significantly increased the HS-Omega-3 Index (p = 0.001), there were no significant effects on indices psychological health and neurocognitive functioning by treatment group. Nevertheless, there was a significant inverse correlation between the changes in the HS-Omega-3 Index and daytime sleepiness (r = 0.30, p = 0.009). Short-term treatment with 2.5 g of omega-3 FAs did not alter measures of neurocognition or psychological health, but there was evidence of a relationship between omega-3 levels and daytime sleepiness. Reprint & Copyright © 2014 Association of Military Surgeons of the U.S.

Effect of diet with omega-3 in basal brain electrical activity and during status epilepticus in rats.

PubMed

Pessoa, Daniella Tavares; da Silva, Eva Luana Almeida; Costa, Edbhergue Ventura Lola; Nogueira, Romildo Albuquerque

2017-11-01

Western diets are high in saturated fat and low in omega-3. Certain animals cannot produce omega-3 from their own lipids, making it necessary for it to be acquired from the diet. However, omega-3s are important components of the plasma membrane, and altering their proportions can promote physical and chemical alterations in the membranes, which may modify neuronal excitability. These alterations occur in healthy individuals, as well as in patients with epilepsy who are more sensitive to changes in brain electrical activity. This study evaluated the effect of a diet supplemented with omega-3 on the basal brain electrical activity both before and during status epilepticus in rats. To evaluate the brain electrical activity, we recorded electrocorticograms (ECoG) of animals both with and without omega-3 supplementation before and during status epilepticus induced by pilocarpine. Calculation of the average brain wave power by a power spectrum revealed that omega-3 supplementation reduced the average power of the delta wave by 20% and increased the average power of the beta wave by 45%. These effects were exacerbated when status epilepticus was induced in the animals supplemented with omega-3. The animals with and without omega-3 supplementation exhibited increases in basal brain electrical activities during status epilepticus. The two groups showed hyperactivity, but no significant difference between them was noted. Even though the brain activity levels observed during status epilepticus were similar between the two groups, neuron damage to the animals supplemented with omega-3 was more slight, revealing the neuroprotective effect of the omega-3. Copyright © 2017 Elsevier B.V. All rights reserved.

Omega 3:6 ratio intake and incidence of glaucoma: the SUN cohort.

PubMed

Pérez de Arcelus, Mónica; Toledo, Estefanía; Martínez-González, Miguel Á; Sayón-Orea, Carmen; Gea, Alfredo; Moreno-Montañés, Javier

2014-12-01

Omega 3 and omega 6 polyunsaturated fatty acids have been related to many diseases, especially to cardiovascular diseases. We aimed to assess the association between the intake of omega 3, omega 6 fatty acids and their ratio and the incidence of glaucoma in this prospective cohort study. We followed-up 17,128 participants initially free of glaucoma for a median time of 8.2 years. Validated data of diet were collected at baseline with a 136-item semi-quantitative food-frequency questionnaire and information of new diagnosis of glaucoma in biennial follow-up questionnaires. Multivariable Cox regression models were fit to assess the relationship between omega 3, omega 6 and their ratio and the incidence of glaucoma in the total sample and in participants aged ≥40 years at baseline. During a median follow-up time of 8.2 years, 156 new cases of glaucoma were identified. No significant association was observed for the omega 3 or the omega 6 intake and the risk of glaucoma. Participants in the highest quintile of omega 3:6 ratio intake had a significantly higher risk of glaucoma than participants in the lowest quintile (hazard ratio (HR): 1.91 [95%CI: 1.05-3.46], p for trend 0.03). The association became stronger (HR for the comparison of the 5th versus the 1st quintile: 2.43 [95%CI: 1.17-5.03], p for trend 0.02) when we considered only those participants who were ≥40 years old. Our data suggest an association between omega 3:6 ratio intake and incident glaucoma in our cohort, especially among older participants. Copyright © 2013 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.

Omega-3 Index and Obstructive Sleep Apnea: A Cross-Sectional Study.

PubMed

Tittus, Janine; Huber, Marie Theres; Storck, Klaus; Köhler, Anton; Köhler, Jan M; von Arnim, Thomas; von Schacky, Clemens

2017-10-15

Erythrocyte levels of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) (Omega-3 Index) were previously found to be associated with obstructive sleep apnea (OSA) at very low levels (< 5.0%) in only one epidemiologic study. OSA has comorbidities, such as arterial hypertension, heart failure, or major depression, also associated with a low Omega-3 Index. These comorbidities can be improved by increasing intake of EPA and DHA, and thus the Omega-3 Index, preferably to its target range of 8% to 11%. Symptoms of OSA might improve by increasing the Omega-3 Index, but more research is needed. In our sleep laboratory, 357 participants with OSA were recruited, and data from 315 participants were evaluated. Three categories of OSA (none/ mild, moderate, severe) were defined based on apnea-hypopnea index. Anthropometrics and lifestyle characteristics (smoking, alcohol, fish intake, omega-3 supplementation) were recorded. Erythrocyte fatty acid compositions were assessed with the HS-Omega-3 Index methodology. The mean Omega-3 Index in all 3 categories of OSA was 5.7%, and no association with OSA was found. There were more male participants with severe OSA (79.7%, P = .042) than females, and participants with severe OSA had a significantly higher body mass index (32.11 ± 6.39 kg/m 2 , P = .009) than participants with mild or moderate OSA. Lifestyle characteristics were not significantly different. In contrast to our hypothesis, an Omega-3 Index of 5.7% was not associated with OSA severity. Previously, an Omega-3 Index < 5.0% was associated. Although our results suggest aiming for an Omega-3 Index > 5.7% in an intervention trial with EPA and DHA in OSA, comorbidities of OSA suggest a target range of 8% to 11%. © 2017 American Academy of Sleep Medicine

Recent Advances in Omega-3: Health Benefits, Sources, Products and Bioavailability

PubMed Central

Nichols, Peter D.; McManus, Alexandra; Krail, Kevin; Sinclair, Andrew J.; Miller, Matt

2014-01-01

The joint symposium of The Omega-3 Centre and the Australasian Section American Oil Chemists Society; Recent Advances in Omega-3: Health Benefits, Sources, Products and Bioavailability, was held November 7, 2013 in Newcastle, NSW, Australia. Over 115 attendees received new information on a range of health benefits, aquaculture as a sustainable source of supply, and current and potential new and novel sources of these essential omega-3 long-chain (LC, ≥C20) polyunsaturated fatty acid nutrients (also termed LC omega-3). The theme of “Food versus Fuel” was an inspired way to present a vast array of emerging and ground breaking Omega-3 research that has application across many disciplines. Eleven papers submitted following from the Omega-3 Symposium are published in this Special Issue volume, with topics covered including: an update on the use of the Omega-3 Index (O3I), the effects of dosage and concurrent intake of vitamins/minerals on omega-3 incorporation into red blood cells, the possible use of the O3I as a measure of risk for adiposity, the need for and progress with new land plant sources of docosahexaenoic acid (DHA, 22:6ω3), the current status of farmed Australian and New Zealand fish, and also supplements, in terms of their LC omega-3 and persistent organic pollutants (POP) content, progress with cheap carbon sources in the culture of DHA-producing single cell organisms, a detailed examination of the lipids of the New Zealand Greenshell mussel, and a pilot investigation of the purification of New Zealand hoki liver oil by short path distillation. The selection of papers in this Special Issue collectively highlights a range of forward looking and also new and including positive scientific outcomes occurring in the omega-3 field. PMID:25255830

Omega-3 fatty acids revert high-fat diet-induced neuroinflammation but not recognition memory impairment in rats.

PubMed

de Andrade, Aline Marcelino; Fernandes, Marilda da Cruz; de Fraga, Luciano Stürmer; Porawski, Marilene; Giovenardi, Márcia; Guedes, Renata Padilha

2017-12-01

Neuroinflammation is a consequence of overeating and may predispose to the development of cognitive decline and neurological disorders. This study aimed to evaluate the impact of omega-3 supplementation on memory and neuroinflammatory markers in rats fed a high-fat diet. Male Wistar rats were divided into four groups: standard diet (SD); standard diet + omega-3 (SD + O); high fat diet (HFD); and high fat diet + omega-3 (HFD + O). Diet administration was performed for 20 weeks and omega-3 supplementation started at the 16th week. HFD significantly increased body weight, while omega-3 supplementation did not modify the total weight gain. However, animals from the HFD + O group showed a lower level of visceral fat along with an improvement in insulin sensitivity following HFD. Thus, our results demonstrate a beneficial metabolic role of omega-3 following HFD. On the other hand, HFD animals presented an impairment in object recognition memory, which was not recovered by omega-3. In addition, there was an increase in GFAP-positive cells in the cerebral cortex of the HFD group, showing that omega-3 supplementation can be effective to decrease astrogliosis. However, no differences in GFAP number of cells were found in the hippocampus. We also demonstrated a significant increase in gene expression of pro-inflammatory cytokines IL-6 and TNF-α in cerebral cortex of the HFD group, reinforcing the anti-inflammatory role of this family of fatty acids. In summary, omega-3 supplementation was not sufficient to reverse the memory deficit caused by HFD, although it played an important role in reducing the neuroinflammatory profile. Therefore, omega-3 fatty acids may play an important role in the central nervous system, preventing the progression of neuroinflammation in obesity.

Associations Between Whole Blood and Dietary Omega-3 Polyunsaturated Fatty Acid Levels in Collegiate Athletes.

PubMed

Wilson, Patrick B; Madrigal, Leilani A

2016-12-01

Omega-3 polyunsaturated fatty acids (PUFAs) have important physiological functions and may offer select benefits for athletic performance and recovery. The purpose of this investigation was to assess dietary and whole blood omega-3 PUFAs among collegiate athletes. In addition, a brief questionnaire was evaluated as a valid tool for quantifying omega-3 PUFA intake. Fifty-eight athletes (9 males, 49 females) completed a 21-item questionnaire developed to assess omega-3 PUFA intake and provided dried whole blood samples to quantify α-linolenic acid (ALA), eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and the HS-Omega-3 Index. Geometric means (95% confidence intervals) for the HS-Omega-3 Index were 4.79% (4.37-5.25%) and 4.75% (4.50-5.01%) for males and females, respectively. Median dietary intakes of ALA, EPA, and DHA were all below 100 mg. Among females, several dietary omega-3 PUFA variables were positively associated with whole blood EPA, with total EPA (rho = 0.67, p < .001) and total DHA (rho = 0.69, p < .001) intakes showing the strongest correlations. Whole blood DHA among females showed positive associations with dietary intakes, with total EPA (rho = 0.62, p < .001) and total DHA (rho = 0.64, p < .001) intakes demonstrating the strongest correlations. The HS-Omega-3 Index in females was positively correlated with all dietary variables except ALA. Among males, the only significant correlation was between food and whole blood EPA (rho = 0.83, p < .01). Collegiate athletes had relatively low intakes of omega-3 PUFAs. A 21-item questionnaire may be useful for screening female athletes for poor omega-3 PUFA status.

Recent advances in omega-3: Health Benefits, Sources, Products and Bioavailability.

PubMed

Nichols, Peter D; McManus, Alexandra; Krail, Kevin; Sinclair, Andrew J; Miller, Matt

2014-09-16

The joint symposium of The Omega-3 Centre and the Australasian Section American Oil Chemists Society; Recent Advances in Omega-3: Health Benefits, Sources, Products and Bioavailability, was held November 7, 2013 in Newcastle, NSW, Australia. Over 115 attendees received new information on a range of health benefits, aquaculture as a sustainable source of supply, and current and potential new and novel sources of these essential omega-3 long-chain (LC, ≥ C20) polyunsaturated fatty acid nutrients (also termed LC omega-3). The theme of "Food versus Fuel" was an inspired way to present a vast array of emerging and ground breaking Omega-3 research that has application across many disciplines. Eleven papers submitted following from the Omega-3 Symposium are published in this Special Issue volume, with topics covered including: an update on the use of the Omega-3 Index (O3I), the effects of dosage and concurrent intake of vitamins/minerals on omega-3 incorporation into red blood cells, the possible use of the O3I as a measure of risk for adiposity, the need for and progress with new land plant sources of docosahexaenoic acid (DHA, 22:6ω3), the current status of farmed Australian and New Zealand fish, and also supplements, in terms of their LC omega-3 and persistent organic pollutants (POP) content, progress with cheap carbon sources in the culture of DHA-producing single cell organisms, a detailed examination of the lipids of the New Zealand Greenshell mussel, and a pilot investigation of the purification of New Zealand hoki liver oil by short path distillation. The selection of papers in this Special Issue collectively highlights a range of forward looking and also new and including positive scientific outcomes occurring in the omega-3 field.

Omega 3 but not omega 6 fatty acids inhibit AP-1 activity and cell transformation in JB6 cells.

PubMed

Liu, G; Bibus, D M; Bode, A M; Ma, W Y; Holman, R T; Dong, Z

2001-06-19

Epidemiological and animal-based investigations have indicated that the development of skin cancer is in part associated with poor dietary practices. Lipid content and subsequently the derived fatty acid composition of the diet are believed to play a major role in the development of tumorigenesis. Omega 3 (omega3) fatty acids, including docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), can effectively reduce the risk of skin cancer whereas omega 6 (omega6) fatty acids such as arachidonic acid (AA) reportedly promote risk. To investigate the effects of fatty acids on tumorigenesis, we performed experiments to examine the effects of the omega3 fatty acids EPA and DHA and of the omega6 fatty acid AA on phorbol 12-tetradecanoate 13-acetate (TPA)-induced or epidermal growth factor (EGF)-induced transcription activator protein 1 (AP-1) transactivation and on the subsequent cellular transformation in a mouse epidermal JB6 cell model. DHA treatment resulted in marked inhibition of TPA- and EGF-induced cell transformation by inhibiting AP-1 transactivation. EPA treatment also inhibited TPA-induced AP-1 transactivation and cell transformation but had no effect on EGF-induced transformation. AA treatment had no effect on either TPA- or EGF-induced AP-1 transactivation or transformation, but did abrogate the inhibitory effects of DHA on TPA- or EGF-induced AP-1 transactivation and cell transformation in a dose-dependent manner. The results of this study demonstrate that the inhibitory effects of omega3 fatty acids on tumorigenesis are more significant for DHA than for EPA and are related to an inhibition of AP-1. Similarly, because AA abrogates the beneficial effects of DHA, the dietary ratio of omega6 to omega3 fatty acids may be a significant factor in mediating tumor development.

Ultrafast Spectroscopic Studies of Two-Photon States in Third Order Optical Processes of Dye Chromophores.

NASA Astrophysics Data System (ADS)

Yu, Yi-Zhong

1995-01-01

Conjugated organic and polymeric materials usually have large, nonresonant third order optical nonlinearity due to correlations of their delocalized pi -electrons. Most materials studied so far show positive values of third order nonlinear susceptibility when all frequencies that generate the third order effect are below any optical transition. A new class of organic molecules, namely indole squarylium (ISQ) and anilinium squarylium (BSQ), exhibit negative < gamma(-omega_4;omega_1, omega_2,omega_3)> when all three frequencies, omega_1, omega_2 and omega_3, lie below the first electronic transition. Although quantum many-electron calculations based on multiple-excitation configuration interaction have shown that the negative third order coefficient is essentially due to the contribution from high-lying two-photon states, the field of experimental studies exploring the microscopic origins of the negative squaraines remains uncultivated. The work presented in this thesis involves extensive experimental investigation of squaraines using techniques such as time-resolved transit absorption spectroscopy and saturable absorption. Theoretical simulations studying nonlinear absorption behavior of a simplified two-level system with ultrashort pulses are also presented. Part of the thesis is dedicated to the development, fabrication and characterization of our ultrafast laser system which offers tunable femtosecond pulses at wavelengths from UV to IR and served as a major tool in the experimental measurements. The dynamics of the population inversion between the ground state and the first excited state was also investigated through time-resolved experiments. The experiment results agree well with the theoretical predictions. Strong couplings between the gateway state and high-lying two-photon states were observed in BSQ squarylium molecules, which suggested a complete quantum calculation with multiple energy levels is required to correctly describe the negative third order effect.

Plasma eicosapentaenoic acid is negatively associated with all-cause mortality among men and women in a population-based prospective study.

PubMed

Miura, Kyoko; Hughes, Maria Celia B; Ungerer, Jacobus Pj; Green, Adèle C

2016-11-01

Omega-3 polyunsaturated fatty acids (PUFAs) have anti-inflammatory properties, whereas omega-6 PUFAs appear to have proinflammatory properties. We aimed to assess plasma omega-3 and omega-6 PUFA status in relation to all-cause mortality in an Australian community-based study. We hypothesized that omega-3 PUFA would be inversely associated, and omega-6 PUFA positively associated with all-cause mortality. Plasma phospholipid omega-3 (eicosapentaenoic acid [EPA], docosapentaenoic acid [DPA], docosahexaenoic acid, α-linolenic acid, and total) and omega-6 PUFAs (linoleic acid, arachidonic acid, and total) were measured among 1008 adults (44% men) in 1996. Plasma PUFA composition was quantified using gas chromatography. During 17-year follow-up, 98 men and 81 women died. After adjustment for potential confounding factors, plasma EPA was inversely associated with all-cause mortality overall (adjusted hazard ratio [HR] per 1-SD increase, 0.81; 95% confidence interval [CI], 0.68-0.95), in men (HR, 0.78; 95% CI, 0.62-0.98), and in women (HR, 0.78; 95% CI, 0.65-0.94), separately. Inverse associations with mortality among men were also seen for DPA (HR, 0.76; 95% CI, 0.60-0.97) and α-linolenic acid (HR, 0.73; 95% CI, 0.57-0.94). No omega-6 PUFAs were significantly associated with mortality. Our findings of reduced all-cause mortality in men and women who have high EPA in plasma, and in men with high plasma DPA and α-linolenic acid, partially support our hypothesis that omega-3 PUFAs help reduce mortality but provide no evidence that omega-6 PUFAs may increase mortality. Copyright © 2016 Elsevier Inc. All rights reserved.

Effects of Ca2+ channel blockers on transmitter release and presynaptic currents at the frog neuromuscular junction.

PubMed Central

Katz, E; Ferro, P A; Cherksey, B D; Sugimori, M; Llinás, R; Uchitel, O D

1995-01-01

1. The effects of the calcium channel blockers, funnel-web spider toxin (FTX), omega-agatoxin IVA (omega-Aga IVA) and omega-conotoxin GVIA (omega-CgTX), were tested on transmitter release and presynaptic currents in frog motor nerve endings. 2. Evoked transmitter release was blocked by FTX (IC50 = 0.02 microliter ml-1) and omega-CgTX (1 microM) but was not affected by omega-Aga IVA (0.5 microM). When FTX (0.1 microliter ml-1) was assayed on spontaneous release either in normal Ringer solution or in low Ca(2+)-high Mg2+ solution, it was found not to affect miniature endplate potential (MEPP) amplitude but to increase MEPP frequency by approximately 2-fold in both conditions. 3. Presynaptic calcium currents (ICa), measured by the perineurial technique in the presence of 10 mM tetraethylammonium chloride (TEA) and 200 microM BaCl2 to block K+ currents, were blocked by omega-CgTX (5 microM), partially blocked by FTX (1 microliter ml-1) and not affected by omega-Aga IVA (0.5 microM). 4. The presynaptic calcium-activated potassium current (IK(Ca)) measured by the perineurial technique in the presence of 0.5 microM 3,4-aminopyridine (DAP) to block voltage-dependent K+ currents, was strongly affected by charybdotoxin (ChTX) (300 nM) and completely abolished by BaCl2 (200 microM). This current was also blocked by omega-CgTX (5 microM) and by CdCl2 (200 microM) but was not affected by FTX (1 microliter ml-1). The blockade by omega-CgTX could not be reversed by elevating [Ca]o to 10 mM. 5. The results suggest that in frog synaptic terminals two omega-CgTX-sensitive populations might coexist. The transmitter release process seems to be mediated by calcium influx through a omega-CgTX- and FTX-sensitive population. PMID:7473230

Effects of Ca2+ channel blockers on transmitter release and presynaptic currents at the frog neuromuscular junction.

PubMed

Katz, E; Ferro, P A; Cherksey, B D; Sugimori, M; Llinás, R; Uchitel, O D

1995-08-01

1. The effects of the calcium channel blockers, funnel-web spider toxin (FTX), omega-agatoxin IVA (omega-Aga IVA) and omega-conotoxin GVIA (omega-CgTX), were tested on transmitter release and presynaptic currents in frog motor nerve endings. 2. Evoked transmitter release was blocked by FTX (IC50 = 0.02 microliter ml-1) and omega-CgTX (1 microM) but was not affected by omega-Aga IVA (0.5 microM). When FTX (0.1 microliter ml-1) was assayed on spontaneous release either in normal Ringer solution or in low Ca(2+)-high Mg2+ solution, it was found not to affect miniature endplate potential (MEPP) amplitude but to increase MEPP frequency by approximately 2-fold in both conditions. 3. Presynaptic calcium currents (ICa), measured by the perineurial technique in the presence of 10 mM tetraethylammonium chloride (TEA) and 200 microM BaCl2 to block K+ currents, were blocked by omega-CgTX (5 microM), partially blocked by FTX (1 microliter ml-1) and not affected by omega-Aga IVA (0.5 microM). 4. The presynaptic calcium-activated potassium current (IK(Ca)) measured by the perineurial technique in the presence of 0.5 microM 3,4-aminopyridine (DAP) to block voltage-dependent K+ currents, was strongly affected by charybdotoxin (ChTX) (300 nM) and completely abolished by BaCl2 (200 microM). This current was also blocked by omega-CgTX (5 microM) and by CdCl2 (200 microM) but was not affected by FTX (1 microliter ml-1). The blockade by omega-CgTX could not be reversed by elevating [Ca]o to 10 mM. 5. The results suggest that in frog synaptic terminals two omega-CgTX-sensitive populations might coexist. The transmitter release process seems to be mediated by calcium influx through a omega-CgTX- and FTX-sensitive population.

In chronic fatigue syndrome, the decreased levels of omega-3 poly-unsaturated fatty acids are related to lowered serum zinc and defects in T cell activation.

PubMed

Maes, Michael; Mihaylova, Ivana; Leunis, Jean-Claude

2005-12-01

There is now evidence that major depression is accompanied by decreased levels of omega3 poly-unsaturated fatty acids (PUFA), such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). There is a strong comorbidity between major depression and chronic fatigue syndrome (CFS). The present study has been carried out in order to examine PUFA levels in CFS. In twenty-two CFS patients and 12 normal controls we measured serum PUFA levels using gas chromatography and mass spectrometry. We found that CFS was accompanied by increased levels of omega6 PUFAs, i.e. linoleic acid and arachidonic acid (AA), and mono-unsaturated fatty acids (MUFAs), i.e. oleic acid. The EPA/AA and total omega3/omega6 ratios were significantly lower in CFS patients than in normal controls. The omega3/omega6 ratio was significantly and negatively correlated to the severity of illness and some items of the FibroFatigue scale, i.e. aches and pain, fatigue and failing memory. The severity of illness was significantly and positively correlated to linoleic and arachidonic acid, oleic acid, omega9 fatty acids and one of the saturated fatty acids, i.e. palmitic acid. In CFS subjects, we found significant positive correlations between the omega3/omega6 ratio and lowered serum zinc levels and the lowered mitogen-stimulated CD69 expression on CD3+, CD3+ CD4+, and CD3+ CD8+ T cells, which indicate defects in early T cell activation. The results of this study show that a decreased availability of omega3 PUFAs plays a role in the pathophysiology of CFS and is related to the immune pathophysiology of CFS. The results suggest that patients with CFS should respond favourably to treatment with--amongst other things--omega3 PUFAs, such as EPA and DHA.

Adjuvant immunotherapy of feline fibrosarcoma with recombinant feline interferon-omega.

PubMed

Hampel, Verena; Schwarz, Bianca; Kempf, Christine; Köstlin, Roberto; Schillinger, Ulrike; Küchenhoff, Helmut; Fenske, Nora; Brill, Thomas; Hirschberger, Johannes

2007-01-01

Recombinant feline interferon-omega (rFeIFN-omega) was tested as a treatment option for cats with fibrosarcoma to assess safety and feasibility. Treatment with rFeIFN-omega in cats with fibrosarcoma is safe and feasible. Twenty domestic cats. In an open-labeled uncontrolled clinical trial 12 injections of 1 x 10(6) U/kg rFeIFN-omega were administered over a 5-week period: the 1st through 4th injections were given intratumorally, and the 5th through 12th injections were administered subcutaneously at the tumor excision site. Wide surgical excision of the tumors was carried out after the 4th injection and before the 5th injection of rFeIFN-omega. A Common Terminology Criteria for Adverse Events (CTCAE) analysis was conducted. Flow cytometry of fibrosarcoma cells after incubation with rFeIFN-omega and recombinant feline interferon-gamma was performed to assess the biological effect of rFeIFN-omega. Changes in blood cell count, increases in serum aspartate-amino-transferase activity, serum bilirubin concentration, serum creatinine and serum electrolyte concentrations, weight loss, anorexia, increased body temperature, and reduced general condition were observed but were mostly minor (grade 1 and 2) and self limiting. Eosinophilia (P = .025), neutropenia (P = .021), and weight loss (P < .001) were statistically correlated with rFeIFN-omega-treatment (analysis of parameters before treatment and after 3 injections of rFeIFN-omega). Flow cytometry of 5 unrelated feline fibrosarcoma cell lines showed increased expression of major histocompatibility complex (MHC) class I molecules (P = .026) in response to in vitro incubation with rFeIFN-omega, whereas expression of MHC class II molecules was not affected significantly. RFeIFN-omega for the treatment of feline fibrosarcoma is safe, well tolerated, and can be easily performed in practice. To assess the efficacy of the treatment, it should be tested in a placebo-controlled trial.

A randomised trial of the effect of omega-3 polyunsaturated fatty acid supplements on the human intestinal microbiota.

PubMed

Watson, Henry; Mitra, Suparna; Croden, Fiona C; Taylor, Morag; Wood, Henry M; Perry, Sarah L; Spencer, Jade A; Quirke, Phil; Toogood, Giles J; Lawton, Clare L; Dye, Louise; Loadman, Paul M; Hull, Mark A

2017-09-26

Omega-3 polyunsaturated fatty acids (PUFAs) have anticolorectal cancer (CRC) activity. The intestinal microbiota has been implicated in colorectal carcinogenesis. Dietary omega-3 PUFAs alter the mouse intestinal microbiome compatible with antineoplastic activity. Therefore, we investigated the effect of omega-3 PUFA supplements on the faecal microbiome in middle-aged, healthy volunteers (n=22). A randomised, open-label, cross-over trial of 8 weeks' treatment with 4 g mixed eicosapentaenoic acid/docosahexaenoic acid in two formulations (soft-gel capsules and Smartfish drinks), separated by a 12-week 'washout' period. Faecal samples were collected at five time-points for microbiome analysis by 16S ribosomal RNA PCR and Illumina MiSeq sequencing. Red blood cell (RBC) fatty acid analysis was performed by liquid chromatography tandem mass spectrometry. Both omega-3 PUFA formulations induced similar changes in RBC fatty acid content, except that drinks were associated with a larger, and more prolonged, decrease in omega-6 PUFA arachidonic acid than the capsule intervention (p=0.02). There were no significant changes in α or β diversity, or phyla composition, associated with omega-3 PUFA supplementation. However, a reversible increased abundance of several genera, including Bifidobacterium , Roseburia and Lactobacillus was observed with one or both omega-3 PUFA interventions. Microbiome changes did not correlate with RBC omega-3 PUFA incorporation or development of omega-3 PUFA-induced diarrhoea. There were no treatment order effects. Omega-3 PUFA supplementation induces a reversible increase in several short-chain fatty acid-producing bacteria, independently of the method of administration. There is no simple relationship between the intestinal microbiome and systemic omega-3 PUFA exposure. ISRCTN18662143. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Omega-3 Fatty Acids and Cardiovascular Disease: Are There Benefits?

PubMed

Bowen, Kate J; Harris, William S; Kris-Etherton, Penny M

2016-11-01

Early secondary prevention trials of fish and omega-3 polyunsaturated fatty acid (PUFA) capsules reported beneficial effects on cardiovascular disease (CVD) outcomes, including all-cause mortality and sudden cardiac death. These clinical findings, as well as observational and experimental data, demonstrated that omega-3 PUFAs reduced the risk of coronary outcomes and overall mortality and were the basis for recommendations made in the early 2000s to increase omega-3 PUFA intake. In the last 6 years, however, results from both primary and secondary prevention trials have generally failed to show a beneficial effect of omega-3 PUFA supplementation, bringing current recommendations into question. Several possible reasons for these null findings have been proposed, including short treatment periods, relatively low doses of omega-3 PUFAs, small sample sizes, higher background omega-3 intakes, and the concurrent use of modern pharmacotherapy for CVD prevention. At least one of these caveats is being assessed in major clinical trials, with two omega-3 PUFA pharmacological agents being tested at doses of 4 g/day (instead of the more common <1 g/day). These null findings, however, do not necessarily mean that omega-3 PUFAs "are ineffective" in general, only that they were not effective in the context in which they were tested. Accordingly, higher intakes of omega-3 PUFAs, either from fatty fish or from supplements, if continued for decades (as the epidemiological data support) are likely to contribute towards lower risk for CVD. At this time, evidence supports the consumption of a healthy dietary pattern with at least two servings per week of fatty fish. Omega-3 PUFA supplementation is a reasonable alternative for those who do not consume fish, although fish is the preferred source of omega-3 PUFAs because it also provides additional nutrients, some of which are often under-consumed.

Blood docosahexaenoic acid and eicosapentaenoic acid in vegans: Associations with age and gender and effects of an algal-derived omega-3 fatty acid supplement.

PubMed

Sarter, Barbara; Kelsey, Kristine S; Schwartz, Todd A; Harris, William S

2015-04-01

Several studies have demonstrated that vegetarians and vegans have much lower plasma concentrations of omega-3 fatty acids (i.e., docosahexaenoic and eicosapentaenoic acids) when compared to those who eat fish. The purposes of this study were 1) to define the age and/or sex-specific docosahexaenoic plus eicosapentaenoic acids levels in red blood cell membranes (expressed as a percent of total fatty acids; hereafter the omega-3 index) in long-term vegans, and 2) to determine the effects of a vegetarian omega-3 supplement (254 mg docosahexaenoic plus eicosapentaenoic acids/day for 4 months) on the omega-3 index. A sample (n = 165) of vegans was recruited, and their omega-3 index was determined using a dried blood spot methodology. A subset of 46 subjects with a baseline omega-3 index of <4% was given a vegetarian omega-3 supplement for 4 months and then retested. The mean ± SD omega-3 index was 3.7 ± 1.0% which was similar to that of a cohort of omnivores (deployed US soldiers) from a recently-reported study. Among the vegan cohort, the index was significantly higher in females than males (3.9 ± 1.0% vs. 3.5 ± 1.0%; p = 0.026) and was directly related to age (p for trend = 0.009). The omega-3 index increased from 3.1 ± 0.6% to 4.8 ± 0.8% (p = 0.009) in the supplementation study. We conclude that vegans have low baseline omega-3 levels, but not lower than omnivores who also consume very little docosahexaenoic and eicosapentaenoic acids. The vegans responded robustly to a relatively low dose of a vegetarian omega-3 supplement. Copyright © 2014 The Authors. Published by Elsevier Ltd.. All rights reserved.

Optimal Control of the Parametric Oscillator

ERIC Educational Resources Information Center

Andresen, B.; Hoffmann, K. H.; Nulton, J.; Tsirlin, A.; Salamon, P.

2011-01-01

We present a solution to the minimum time control problem for a classical harmonic oscillator to reach a target energy E[subscript T] from a given initial state (q[subscript i], p[subscript i]) by controlling its frequency [omega], [omega][subscript min] less than or equal to [omega] less than or equal to [omega][subscript max]. A brief synopsis…

40 CFR 721.2222 - Cyclohexanamine, N,N-dimethyl-, compd. with alpha-isotridecyl-omega-hydroxypoly(oxy-1,2...

Code of Federal Regulations, 2011 CFR

2011-07-01

.... with alpha-isotridecyl-omega-hydroxypoly(oxy-1,2-ethanediyl) phosphate. 721.2222 Section 721.2222... Cyclohexanamine, N,N-dimethyl-, compd. with alpha-isotridecyl-omega-hydroxypoly(oxy-1,2-ethanediyl) phosphate. (a... cyclohexanamine, N,N-dimethyl-, compd. with alpha-isotridecyl-omega-hydroxypoly(oxy-1,2-ethanediyl) phosphate (PMN...

40 CFR 721.2222 - Cyclohexanamine, N,N-dimethyl-, compd. with alpha-isotridecyl-omega-hydroxypoly(oxy-1,2...

Code of Federal Regulations, 2014 CFR

2014-07-01

.... with alpha-isotridecyl-omega-hydroxypoly(oxy-1,2-ethanediyl) phosphate. 721.2222 Section 721.2222... Cyclohexanamine, N,N-dimethyl-, compd. with alpha-isotridecyl-omega-hydroxypoly(oxy-1,2-ethanediyl) phosphate. (a... cyclohexanamine, N,N-dimethyl-, compd. with alpha-isotridecyl-omega-hydroxypoly(oxy-1,2-ethanediyl) phosphate (PMN...

40 CFR 721.2222 - Cyclohexanamine, N,N-dimethyl-, compd. with alpha-isotridecyl-omega-hydroxypoly(oxy-1,2...

Code of Federal Regulations, 2012 CFR

2012-07-01

.... with alpha-isotridecyl-omega-hydroxypoly(oxy-1,2-ethanediyl) phosphate. 721.2222 Section 721.2222... Cyclohexanamine, N,N-dimethyl-, compd. with alpha-isotridecyl-omega-hydroxypoly(oxy-1,2-ethanediyl) phosphate. (a... cyclohexanamine, N,N-dimethyl-, compd. with alpha-isotridecyl-omega-hydroxypoly(oxy-1,2-ethanediyl) phosphate (PMN...

40 CFR 721.2222 - Cyclohexanamine, N,N-dimethyl-, compd. with alpha-isotridecyl-omega-hydroxypoly(oxy-1,2...

Code of Federal Regulations, 2013 CFR

2013-07-01

.... with alpha-isotridecyl-omega-hydroxypoly(oxy-1,2-ethanediyl) phosphate. 721.2222 Section 721.2222... Cyclohexanamine, N,N-dimethyl-, compd. with alpha-isotridecyl-omega-hydroxypoly(oxy-1,2-ethanediyl) phosphate. (a... cyclohexanamine, N,N-dimethyl-, compd. with alpha-isotridecyl-omega-hydroxypoly(oxy-1,2-ethanediyl) phosphate (PMN...

OMEGA Navigation System Synchronization

DTIC Science & Technology

1982-12-01

DEC 1982 2. REPORT TYPE 3. DATES COVERED 00-00-1982 to 00-00-1982 4. TITLE AND SUBTITLE OMEGA Navigation System Synchronization 5a. CONTRACT...l execution of ONSOD’s annual $5 mi l l ion budget. OMEGA SYSTEM SYNCHRONIZATION One of ONSOD’s p r inc ipa l missions i s t o ensure the...OMEGA system i s maintained within es tabl ished timing t o l e r a ~ c e s . A l l OMEGA s t a t i o n s transmissions a r e synchronized , so t h

[Antioxidant activity of vegetable oils with various omega-6/omega-3 fatty acids ratio].

PubMed

Guseva, D A; Prozorovskaia, N N; Shironin, A V; Sanzhakov, M A; Evteeva, N M; Rusina, I F; Kasaikina, O T

2010-01-01

Antioxidant activity and the oxidative stability were investigated in flax, sesame, silybum oils and oils with different omega-6/omega-3 fatty acid ratio. The content of antioxidants (AO) in crude oils and their reactivity towards peroxyl radicals were studied using kinetic method for addition of oil in a model reaction of cumol oxidation. There were correlations between PUFA/omega-9 and thermal stability (50 degrees C); between gamma-tocopherol content and resistantance to oxidative changes after storage at (10 +/- 2) degrees C for 6 months.

Retina and Omega-3

PubMed Central

Querques, Giuseppe; Forte, Raimondo; Souied, Eric H.

2011-01-01

Over the last decade, several epidemiological studies based on food frequency questionnaires suggest that omega-3 polyunsaturated fatty acids could have a protective role in reducing the onset and progression of retinal diseases. The retina has a high concentration of omega-3, particularly DHA, which optimizes fluidity of photoreceptor membranes, retinal integrity, and visual function. Furthermore, many studies demonstrated that DHA has a protective, for example antiapoptotic, role in the retina. From a nutritional point of view, it is known that western populations, particularly aged individuals, have a higher than optimal omega-6/omega-3 ratio and should enrich their diet with more fish consumption or have DHA supplementation. This paper underscores the potential beneficial effect of omega-3 fatty acids on retinal diseases. PMID:22175009

Does lower Omega allow a resolution of the large-scale structure problem?

NASA Technical Reports Server (NTRS)

Silk, Joseph; Vittorio, Nicola

1987-01-01

The intermediate angular scale anisotropy of the cosmic microwave background, peculiar velocities, density correlations, and mass fluctuations for both neutrino and baryon-dominated universes with Omega less than one are evaluated. The large coherence length associated with a low-Omega, hot dark matter-dominated universe provides substantial density fluctuations on scales up to 100 Mpc: there is a range of acceptable models that are capable of producing large voids and superclusters of galaxies and the clustering of galaxy clusters, with Omega roughly 0.3, without violating any observational constraint. Low-Omega, cold dark matter-dominated cosmologies are also examined. All of these models may be reconciled with the inflationary requirement of a flat universe by introducing a cosmological constant 1-Omega.

CERN and high energy physics, the grand picture

ScienceCinema

Heuer, Rolf-Dieter

2018-05-24

The lecture will touch on several topics, to illustrate the role of CERN in the present and future of high-energy physics: how does CERN work? What is the role of the scientific community, of bodies like Council and SPC, and of international cooperation, in the definition of CERN's scientific programme? What are the plans for the future of the LHC and of the non-LHC physics programme? What is the role of R&D; and technology transfer at CERN?

P-type calcium channels in rat neocortical neurones.

PubMed Central

Brown, A M; Sayer, R J; Schwindt, P C; Crill, W E

1994-01-01

1. The high threshold, voltage-activated (HVA) calcium current was recorded from acutely isolated rat neocortical pyramidal neurones using the whole-cell patch technique to examine the effect of agents that block P-type calcium channels and to compare their effects to those of omega-conotoxin GVIA (omega-CgTX) and nifedipine. 2. When applied at a saturating concentration (100 nM) the peptide toxins omega-Aga-IVA and synthetic omega-Aga-IVA blocked 31.5 and 33.0% of the HVA current respectively. 3. A saturating concentration of nifedipine (10 microM) inhibited 48.2% of the omega-Aga-IVA-sensitive current, whereas saturating concentrations of both omega-Aga-IVA (100 nM) and omega-CgTX (10 microM) blocked separate specific components of the HVA current. 4. Partially purified funnel web spider toxin (FTX) at a dilution of 1:1000 blocked 81.4% of the HVA current and occluded the inhibitory effect of omega-Aga-IVA. Synthetic FTX 3.3 arginine polyamine (sFTX) at a concentration of 1 mM blocked 61.2% of the HVA current rapidly and reversibly. The effects of sFTX were partially occluded by pre-application of omega-Aga-IVA. We conclude that neither FTX nor sFTX blocked a specific component of the HVA current in these cells. 5. In view of the specificity of omega-Aga-IVA for P-type calcium channels in other preparations and for a specific component of the HVA current in dissociated neocortical neurones we conclude that about 30% of the HVA current in these neurones flow through P-channels. PMID:7517449

P-type calcium channels in rat neocortical neurones.

PubMed

Brown, A M; Sayer, R J; Schwindt, P C; Crill, W E

1994-03-01

1. The high threshold, voltage-activated (HVA) calcium current was recorded from acutely isolated rat neocortical pyramidal neurones using the whole-cell patch technique to examine the effect of agents that block P-type calcium channels and to compare their effects to those of omega-conotoxin GVIA (omega-CgTX) and nifedipine. 2. When applied at a saturating concentration (100 nM) the peptide toxins omega-Aga-IVA and synthetic omega-Aga-IVA blocked 31.5 and 33.0% of the HVA current respectively. 3. A saturating concentration of nifedipine (10 microM) inhibited 48.2% of the omega-Aga-IVA-sensitive current, whereas saturating concentrations of both omega-Aga-IVA (100 nM) and omega-CgTX (10 microM) blocked separate specific components of the HVA current. 4. Partially purified funnel web spider toxin (FTX) at a dilution of 1:1000 blocked 81.4% of the HVA current and occluded the inhibitory effect of omega-Aga-IVA. Synthetic FTX 3.3 arginine polyamine (sFTX) at a concentration of 1 mM blocked 61.2% of the HVA current rapidly and reversibly. The effects of sFTX were partially occluded by pre-application of omega-Aga-IVA. We conclude that neither FTX nor sFTX blocked a specific component of the HVA current in these cells. 5. In view of the specificity of omega-Aga-IVA for P-type calcium channels in other preparations and for a specific component of the HVA current in dissociated neocortical neurones we conclude that about 30% of the HVA current in these neurones flow through P-channels.

Therapeutic Effects of Omega-3 Fatty Acids on Chronic Kidney Disease-Associated Pruritus: a Literature Review

PubMed Central

Panahi, Yunes; Dashti-Khavidaki, Simin; Farnood, Farahnoosh; Noshad, Hamid; Lotfi, Mahsa; Gharekhani, Afshin

2016-01-01

Uremic pruritus remains one of the most tormenting, frequent and potentially disabling problem in chronic kidney disease (CKD) patients. However, an area of substantial etiological interest with relation to uremic pruritus is the essential fatty acids deficiency. So we performed a literature review to elucidate the efficacy of omega-3 fatty acids on uremic pruritus. This review evaluated all of the studies published in English language, focusing on the clinical effects of omega-3 fatty acids on uremic pruritus. The literature review was conducted in December 2015 and carried out by searching Scopus, Medline, Cochrane central register of controlled trials, and Cochrane database of systematic reviews. The search terms were "kidney injury", "kidney failure", "chronic kidney disease", "end-stage renal disease", "dialysis", "hemodialysis", "peritoneal dialysis", "pruritus", "itch", "skin problems", "fish oil", "omega 3", "n-3 fatty acids", "polyunsaturated fatty acids", "docosahexaenoic acid", and "eicosapentaenoic acid". Four small studies investigating potential benefits of omega-3 fatty acids on symptoms of uremic pruritus were found. Among them, three small randomized controlled trials have shown a significant improvement in pruritus symptoms (evaluated by a standard questionnaire) in CKD patients who took omega-3 supplement compared to omega-6, omega-9, and placebo supplementation. Despite numerous limitations of the studies, it is worth noting that even minor reduction in itching symptoms may be clinically significant for CKD patients. Therefore, and considering multiple health benefits of omega-3 fatty acids in advanced CKD and negligible risk profile, omega-3 intake can wisely be applied to CKD patients with uremic pruritus. PMID:28101457

Vitamin D Uptake in Patients Treated with a High-Dosed Purified Omega-3 Compound in a Randomized Clinical Trial Following an Acute Myocardial Infarction.

PubMed

Naesgaard, Patrycja A; Grundt, Heidi; Nordøy, Arne F; Staines, Harry; Nilsen, Dennis W T

2017-01-01

Fish is the natural dietary source of vitamin D. Reports on the influence of purified omega-3 fatty acids on its uptake are scarce. We investigated the impact of a purified high-dose omega-3 compound compared to corn oil on 25-hydroxyvitamin D [25(OH)D] levels following an acute myocardial infarction. 228 patients were randomized 1:1 to receive a daily dose of either 4 g omega-3 (OMACOR ® ) or an equal dose of corn oil, administered double-blindly for 12 months. Total omega-3 and omega-6 measurements were available in 40 randomly picked patients. There was no significant intergroup difference in 25(OH)D changes at 12 months follow-up ( p  = 0.12), but there was a minor statistical significant intragroup increase in 25(OH)D in both intervention arms ( p  < 0.001 for n-3 polyunsaturated fatty acids and p  = 0.013 for corn oil, respectively). A positive correlation was noted between 25(OH)D and omega-3 prior to inclusion; r  = 0.418, p  = 0.007, attenuated at 12 months by purified omega-3 intervention; r  = 0.021, p  = 0.93. No positive correlation was observed between omega-6 and 25(OH)D. Long-term treatment with a high dose of purified omega-3 as compared to corn oil did not improve serum concentrations of vitamin D. ClinicalTrials.gov, Identifier: NCT01422317.

Leukotriene B4 omega-hydroxylase in human polymorphonuclear leukocytes. Suicidal inactivation by acetylenic fatty acids.

PubMed

Shak, S; Reich, N O; Goldstein, I M; Ortiz de Montellano, P R

1985-10-25

Human polymorphonuclear leukocytes (PMN) not only generate and respond to leukotriene B4 (LTB4), but also catabolize this mediator of inflammation rapidly and specifically by omega-oxidation (probably due to the action of a cytochrome P-450 enzyme). To develop pharmacologically useful inhibitors of the LTB4 omega-hydroxylase in human PMN, we devised a general scheme for synthesizing terminal acetylenic fatty acids based on the "acetylenic zipper" reaction. We found that the LTB4 omega-hydroxylase in intact PMN and in PMN sonicates is inactivated in a concentration-dependent fashion by terminal acetylenic analogues of lauric, palmitic, and stearic acids (i.e. 11-dodecynoic, 15-hexadecynoic, and 17-octadecynoic acids). Consistent with a suicidal process, inactivation of the LTB4 omega-hydroxylase requires molecular oxygen and NADPH, is time-dependent, and follows pseudo-first-order kinetics. Inactivation of the omega-hydroxylase by acetylenic fatty acids also is dependent on the terminal acetylenic moiety and the carbon chain length. Saturated fatty acids lacking a terminal acetylenic moiety do not inactivate the omega-hydroxylase. In addition, the two long-chain (C16, C18) acetylenic fatty acids inactivate the omega-hydroxylase at much lower concentrations (less than 5.0 microM) than those required for inactivation by the short-chain (C12) terminal acetylenic fatty acid (100 microM). Potent suicidal inhibitors of the LTB4 omega-hydroxylase in human PMN will help elucidate the roles played by LTB4 and its omega-oxidation products in regulating PMN function and in mediating inflammation.

Cardiovascular disease and omega-3s: Prescription products and fish oil dietary supplements are not the same.

PubMed

Gutstein, Adina S; Copple, Tina

2017-12-01

Despite achievement of optimal low-density lipoprotein cholesterol (LDL-C) control with statin therapy, patients with elevated triglycerides (TGs) and residual cardiovascular risk are commonly encountered in clinical practice. We present information from completed and ongoing clinical trials examining Rx omega-3s for TG-lowering and omega-3 dietary supplements to highlight important differences affecting patient management for nurse practitioners. Rx omega-3s demonstrate robust reductions in TGs and may have a role in reducing residual cardiovascular risk. Products containing docosahexaenoic acid (DHA) may raise LDL-C and should not be substituted for Rx eicosapentaenoic acid (EPA)-only icosapent ethyl, which does not raise LDL-C. Omega-3 dietary supplements (e.g., fish oils containing EPA and DHA) may be used for general health promotion; however, they are not regulated as medications and concerns regarding quality, purity, safety, and variability of content exist. It is important to advise patients that omega-3 dietary supplements are not medications and should not be substituted for Rx omega-3s. Large-scale cardiovascular outcomes studies are underway for Rx omega-3s in statin-treated patients. Nurse practitioners can take an active role in reducing residual cardiovascular risk and educating patients about important differences between Rx omega-3s and fish oil supplements. ©2017 American Association of Nurse Practitioners.

Evaluation of chronic omega-3 fatty acids supplementation on behavioral and neurochemical alterations in 6-hydroxydopamine-lesion model of Parkinson's disease.

PubMed

Delattre, Ana Marcia; Kiss, Agata; Szawka, Raphael E; Anselmo-Franci, Janete A; Bagatini, Pamela Brambilla; Xavier, Léder Leal; Rigon, Paula; Achaval, Matilde; Iagher, Fabíola; de David, Cíntia; Marroni, Norma A P; Ferraz, Anete Curte

2010-03-01

Omega-3 polyunsaturated fatty acids (omega-3 PUFAs) have been widely associated to beneficial effects over different neuropathologies, but only a few studies associate them to Parkinson's disease (PD). Rats were submitted to chronic supplementation (21-90 days of life) with fish oil, rich in omega-3 PUFAs, and were uni- or bilaterally lesioned with 4microg of the neurotoxin 6-hydroxydopamine (6-OHDA) in the medial forebrain bundle. Although lipid incorporation was evidenced in neuronal membranes, it was not sufficient to compensate motor deficits induced by 6-OHDA. In contrast, omega-3 PUFAs were capable of reducing rotational behavior induced by apomorphine, suggesting neuroprotection over dyskinesia. The beneficial effects of omega-3 PUFAs were also evident in the maintenance of thiobarbituric acid reactive substances index from animals lesioned with 6-OHDA similar to levels from SHAM and intact animals. Although omega-3 PUFAs did not modify the tyrosine hydroxylase immunoreactivity in the substantia nigra pars compacta and in the ventral tegmental area, nor the depletion of dopamine (DA) and its metabolites in the striatum, DA turnover was increased after omega-3 PUFAs chronic supplementation. Therefore, it is proposed that omega-3 PUFAs action characterizes the adaptation of remaining neurons activity, altering striatal DA turnover without modifying the estimated neuronal population.

Association between omega-3 fatty acids consumption and the risk of type 2 diabetes: A meta-analysis of cohort studies.

PubMed

Chen, Cai; Yang, Yan; Yu, Xuefeng; Hu, Shuhong; Shao, Shiying

2017-07-01

Epidemiological evidence for the effect of omega-3 fatty acids on the risk of type 2 diabetes is controversial. A meta-analysis based on prospective cohorts was carried out to evaluate this issue. Pooled diabetic risk was calculated using a fixed or random effects model. The dose-response relationship was assessed by meta-regression analysis. The study showed that consumption of single omega-3 was associated with an increased risk of type 2 diabetes (relative risk [RR] = 1.45, P < 0.001); whereas the RR for mixed omega-3 was statistically insignificant. The dose-response curve presented an inverted U-shape of diabetes risk corresponding to the dose of omega-3 consumption. Subanalysis showed that omega-3 was inversely associated with type 2 diabetes risk in Asians (RR = 0.82, P < 0.001); whereas the risk was increased in Westerners (RR = 1.30, P < 0.001). Studies with follow-up duration ≥16 years and baseline age ≥54 years showed a positive association between type 2 diabetes risk and omega-3 intake. The present findings suggest that dosage and composition of omega-3, ethnicity, trial duration, and age could influence the effect of omega-3 on type 2 diabetes progression. © 2016 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd.

Morphologies of omega band auroras

NASA Astrophysics Data System (ADS)

Sato, Natsuo; Yukimatu, Akira Sessai; Tanaka, Yoshimasa; Hori, Tomoaki

2017-08-01

We examined the morphological signatures of 315 omega band aurora events observed using the Time History of Events and Macroscale Interactions during Substorm ground-based all-sky imager network over a period of 8 years. We find that omega bands can be classified into the following three subtypes: (1) classical (O-type) omega bands, (2) torch or tongue (T-type) omega bands, and (3) combinations of classical and torch or tongue (O/T-type) omega bands. The statistical results show that T-type bands occur the most frequently (45%), followed by O/T-type bands (35%) and O-type bands (18%). We also examined the morphologies of the omega bands during their formation, from the growth period to the declining period through the maximum period. Interestingly, the omega bands are not stable, but rather exhibit dynamic changes in shape, intensity, and motion. They grow from small-scale bumps (seeds) at the poleward boundary of preexisting east-west-aligned auroras, rather than via the rotation or shear motion of preexisting east-west-aligned auroras, and do not exhibit any shear motion during the periods of auroral activity growth. Furthermore, the auroral luminosity is observed to increase during the declining period, and the total time from the start of the growth period to the end of the declining period is found to be about 20 min. Such dynamical signatures may be important in determining the mechanism responsible for omega band formation.

Dietary omega-3 PUFA and health: stearidonic acid-containing seed oils as effective and sustainable alternatives to traditional marine oils.

PubMed

Surette, Marc E

2013-05-01

The daily consumption of dietary omega-3 PUFA is recommended by governmental agencies in several countries and by a number of health organizations. The molecular mechanisms by which these dietary PUFA affect health involve the enrichment of cellular membranes with long-chain 20- and 22-carbon omega-3 PUFA that impacts tissues by altering membrane protein functions, cell signaling, and gene expression profiles. These changes are recognized to have health benefits in humans, especially relating to cardiovascular outcomes. Cellular membrane enrichment and health benefits are associated with the consumption of long-chain omega-3 PUFA found in marine oils, but are not generally linked with the consumption of alpha-linolenic acid, the 18-carbon omega-3 PUFA found in plant seed oils. However, the supply of omega-3 PUFA from marine sources is limited and may not be sustainable. New plant-derived sources of omega-3 PUFA like stearidonic acid-soy oil from genetically modified soybeans and Ahiflower oil from Buglossoides arvensis seeds that are enriched in the 18-carbon omega-3 PUFA stearidonic acid are being developed and show promise to become effective as well as sustainable sources of omega-3 PUFA. An example of changes in tissue lipid profiles associated with the consumption of Ahiflower oil is presented in a mouse feeding study. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

40 CFR 721.10283 - Poly[oxy(methyl-1,2-ethanediyl)], .alpha.-sulfo-.omega.-hydroxy-, C12-13-branched and linear...

Code of Federal Regulations, 2013 CFR

2013-07-01

...)], .alpha.-sulfo-.omega.-hydroxy-, C12-13-branched and linear alkyl ethers, sodium salts. 721.10283 Section... Substances § 721.10283 Poly[oxy(methyl-1,2-ethanediyl)], .alpha.-sulfo-.omega.-hydroxy-, C12-13-branched and.... (1) The chemical substance identified as poly[oxy(methyl-1,2-ethanediyl)], .alpha.-sulfo-.omega...

40 CFR 721.10284 - Poly[oxy(methyl-1,2-ethanediyl)], .alpha.-sulfo-.omega.-hydroxy-, C14-15-branched and linear...

Code of Federal Regulations, 2012 CFR

2012-07-01

...)], .alpha.-sulfo-.omega.-hydroxy-, C14-15-branched and linear alkyl ethers, sodium salts. 721.10284 Section... Substances § 721.10284 Poly[oxy(methyl-1,2-ethanediyl)], .alpha.-sulfo-.omega.-hydroxy-, C14-15-branched and.... (1) The chemical substance identified as poly[oxy(methyl-1,2-ethanediyl)], .alpha.-sulfo-.omega...

40 CFR 721.10284 - Poly[oxy(methyl-1,2-ethanediyl)], .alpha.-sulfo-.omega.-hydroxy-, C14-15-branched and linear...

Code of Federal Regulations, 2014 CFR

2014-07-01

...)], .alpha.-sulfo-.omega.-hydroxy-, C14-15-branched and linear alkyl ethers, sodium salts. 721.10284 Section... Substances § 721.10284 Poly[oxy(methyl-1,2-ethanediyl)], .alpha.-sulfo-.omega.-hydroxy-, C14-15-branched and.... (1) The chemical substance identified as poly[oxy(methyl-1,2-ethanediyl)], .alpha.-sulfo-.omega...

40 CFR 721.10283 - Poly[oxy(methyl-1,2-ethanediyl)], .alpha.-sulfo-.omega.-hydroxy-, C12-13-branched and linear...

Code of Federal Regulations, 2012 CFR

2012-07-01

...)], .alpha.-sulfo-.omega.-hydroxy-, C12-13-branched and linear alkyl ethers, sodium salts. 721.10283 Section... Substances § 721.10283 Poly[oxy(methyl-1,2-ethanediyl)], .alpha.-sulfo-.omega.-hydroxy-, C12-13-branched and.... (1) The chemical substance identified as poly[oxy(methyl-1,2-ethanediyl)], .alpha.-sulfo-.omega...

40 CFR 721.10284 - Poly[oxy(methyl-1,2-ethanediyl)], .alpha.-sulfo-.omega.-hydroxy-, C14-15-branched and linear...

Code of Federal Regulations, 2013 CFR

2013-07-01

...)], .alpha.-sulfo-.omega.-hydroxy-, C14-15-branched and linear alkyl ethers, sodium salts. 721.10284 Section... Substances § 721.10284 Poly[oxy(methyl-1,2-ethanediyl)], .alpha.-sulfo-.omega.-hydroxy-, C14-15-branched and.... (1) The chemical substance identified as poly[oxy(methyl-1,2-ethanediyl)], .alpha.-sulfo-.omega...

40 CFR 721.10283 - Poly[oxy(methyl-1,2-ethanediyl)], .alpha.-sulfo-.omega.-hydroxy-, C12-13-branched and linear...

Code of Federal Regulations, 2014 CFR

2014-07-01

...)], .alpha.-sulfo-.omega.-hydroxy-, C12-13-branched and linear alkyl ethers, sodium salts. 721.10283 Section... Substances § 721.10283 Poly[oxy(methyl-1,2-ethanediyl)], .alpha.-sulfo-.omega.-hydroxy-, C12-13-branched and.... (1) The chemical substance identified as poly[oxy(methyl-1,2-ethanediyl)], .alpha.-sulfo-.omega...

Enhancement of optical Kerr effect in quantum-cascade lasers with multiple resonance levels.

PubMed

Bai, Jing; Citrin, D S

2008-08-18

In this paper, we investigated the optical Kerr lensing effect in quantum-cascade lasers with multiple resonance levels. The Kerr refractive index n2 is obtained through the third-order susceptibility at the fundamental frequency chi(3)( omega; omega, omega,-omega). Resonant two-photon processes are found to have almost equal contributions to chi(3)( omega; omega, omega,-omega) as the single-photon processes, which result in the predicted enhancement of the positive nonlinear (Kerr) refractive index, and thus may enhance mode-locking of quantum-cascade lasers. Moreover, we also demonstrate an isospectral optimization strategy for further improving n2 through the band-structure design, in order to boost the multimode performance of quantum-cascade lasers. Simulation results show that the optimized stepwise multiple-quantum-well structure has n2 approximately 10-8 cm2/W, a twofold enhancement over the original flat quantum-well structure. This leads to a refractive-index change (delta)n of about 0.01, which is at the upper bound of those reported for typical Kerr medium. This stronger Kerr refractive index may be important for quantum-cascade lasers ultimately to demonstrate self-mode-locking.

Omega-3 polyunsaturated fatty acids for cardiovascular diseases: present, past and future.

PubMed

Watanabe, Yasuhiro; Tatsuno, Ichiro

2017-08-01

Large-scale epidemiological studies on Greenlandic, Canadian and Alaskan Eskimos have examined the health benefits of omega-3 fatty acids consumed as part of the diet, and found statistically significant relative reduction in cardiovascular risk in people consuming omega-3 fatty acids. Areas covered: This article reviews studies on omega-3 fatty acids during the last 50 years, and identifies issues relevant to future studies on cardiovascular (CV) risk. Expert commentary: Although a meta-analysis of large-scale prospective cohort studies and randomized studies reported that fish and fish oil consumption reduced coronary heart disease-related mortality and sudden cardiac death, omega-3 fatty acids have not yet been shown to be effective in secondary prevention trials on patients with multiple cardiovascular disease (CVD) risk factors. The ongoing long-term CV interventional outcome studies investigate high-dose, prescription-strength omega-3 fatty acids. The results are expected to clarify the potential role of omega-3 fatty acids in reducing CV risk. The anti-inflammatory properties of omega-3 fatty acids are also important. Future clinical trials should also focus on the role of these anti-inflammatory mediators in human arteriosclerotic diseases as well as inflammatory diseases.

Arc-evaporated carbon films: Optical properties and electron mean free paths

DOE Office of Scientific and Technical Information (OSTI.GOV)

Arakawa, E.T.; Dolfini, S.M.; Ashley, J.C.

1985-06-15

The real and imaginary parts of the complex refractive index, n(..omega..) = n(..omega..)+ik(..omega..), of arc-evaporated carbon films have been obtained over the range of photon energies h..omega.. from 0.5 to 62.0 eV. Values of k(..omega..) obtained from transmission measurements in this energy range were combined with values of k(..omega..) from the literature in the infrared and soft-x-ray regions. A Kramers-Kronig analysis then yielded the values of n(..omega..). The density of the arc-evaporated carbon films was found to be 1.90 +- 0.05 g cm/sup -3/ by the ''sink-float'' method, and their thicknesses were determined optically. A sum-rule calculation yielded the effectivemore » numbers of valence and core electrons to be 4.2 and 1.8, respectively. The experimental values determined for n(..omega..) have been used to estimate values of the inelastic mean free path ..lambda..(E) for electrons of energy E from 200 to 3000 eV in amorphous carbon. Good agreement is found between ..lambda..(E) and experimentally determined values of electron attenuation length L(E) from the literature.« less

A lower ratio of omega-6 to omega-3 fatty acids predicts better hippocampus-dependent spatial memory and cognitive status in older adults.

PubMed

Andruchow, Nadia D; Konishi, Kyoko; Shatenstein, Bryna; Bohbot, Véronique D

2017-10-01

Evidence from several cross-sectional studies indicates that an increase in omega-6 to omega-3 fatty acids (FAs) may negatively affect cognition in old age. The hippocampus is among the first neural structures affected by age and atrophy in this brain region is associated with cognitive decline. Therefore, we hypothesized that a lower omega-6:3 FA ratio would predict better hippocampus-dependent spatial memory, and a higher general cognitive status. Fifty-two healthy older adults completed a Food Frequency Questionnaire, the Montreal Cognitive Assessment test (MoCA; a test of global cognition) and virtual navigation tasks that assess navigational strategies and spatial memory. In this cross-sectional study, a lower ratio of omega-6 to omega-3 FA intake strongly predicted more accurate hippocampus-dependent spatial memory and faster learning on our virtual navigation tasks, as well as higher cognitive status overall. These results may help elucidate why certain dietary patterns with a lower omega-6:3 FA ratio, like the Mediterranean diet, are associated with reduced risk of cognitive decline. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

The response of an expert panel to Nutritional armor for the warfighter: can omega-3 fatty acids enhance stress resilience, wellness, and military performance?

PubMed

Coulter, Ian D

2014-11-01

Recommendations of an Expert Panel on 5 central questions addressed during the workshop. The Panel reviewed available scientific literature, workshop presentations, and comments from workshop guests. The Panel unanimously agreed that a military Daily Recommended Intake for long-chain omega-3 fatty acids (FAs) should be established within the context of lowering current intakes of omega-6 FAs. The Panelists also felt that there was sufficient evidence to support increasing omega-3 intake to receive cardiovascular, immunological, and surgical benefits. In addition, research indicates that preloading with omega-3 FAs before combat exposure may be beneficial. Evidence for reduction of depressive symptoms and suicide prevention was felt to be strong. Insufficient data were available to evaluate post-traumatic stress disorder and impulsive aggression. Benefits for traumatic brain injury were promising. Adverse side effects were deemed negligible. The Panel concluded that based on studies analyzing omega-3 and omega-6 FA balance, it would be unethical to not attempt elevating the omega-3 status among U.S. military personnel. Reprint & Copyright © 2014 Association of Military Surgeons of the U.S.

Robust Coefficients Alpha and Omega and Confidence Intervals With Outlying Observations and Missing Data: Methods and Software.

PubMed

Zhang, Zhiyong; Yuan, Ke-Hai

2016-06-01

Cronbach's coefficient alpha is a widely used reliability measure in social, behavioral, and education sciences. It is reported in nearly every study that involves measuring a construct through multiple items. With non-tau-equivalent items, McDonald's omega has been used as a popular alternative to alpha in the literature. Traditional estimation methods for alpha and omega often implicitly assume that data are complete and normally distributed. This study proposes robust procedures to estimate both alpha and omega as well as corresponding standard errors and confidence intervals from samples that may contain potential outlying observations and missing values. The influence of outlying observations and missing data on the estimates of alpha and omega is investigated through two simulation studies. Results show that the newly developed robust method yields substantially improved alpha and omega estimates as well as better coverage rates of confidence intervals than the conventional nonrobust method. An R package coefficientalpha is developed and demonstrated to obtain robust estimates of alpha and omega.

Robust Coefficients Alpha and Omega and Confidence Intervals With Outlying Observations and Missing Data

PubMed Central

Zhang, Zhiyong; Yuan, Ke-Hai

2015-01-01

Cronbach’s coefficient alpha is a widely used reliability measure in social, behavioral, and education sciences. It is reported in nearly every study that involves measuring a construct through multiple items. With non-tau-equivalent items, McDonald’s omega has been used as a popular alternative to alpha in the literature. Traditional estimation methods for alpha and omega often implicitly assume that data are complete and normally distributed. This study proposes robust procedures to estimate both alpha and omega as well as corresponding standard errors and confidence intervals from samples that may contain potential outlying observations and missing values. The influence of outlying observations and missing data on the estimates of alpha and omega is investigated through two simulation studies. Results show that the newly developed robust method yields substantially improved alpha and omega estimates as well as better coverage rates of confidence intervals than the conventional nonrobust method. An R package coefficientalpha is developed and demonstrated to obtain robust estimates of alpha and omega. PMID:29795870

Transposition of an intron in yeast mitochondria requires a protein encoded by that intron.

PubMed

Macreadie, I G; Scott, R M; Zinn, A R; Butow, R A

1985-06-01

The optional 1143 bp intron in the yeast mitochondrial 21S rRNA gene (omega +) is nearly quantitatively inserted in genetic crosses into 21S rRNA alleles that lack it (omega -). The intron contains an open reading frame that can encode a protein of 235 amino acids, but no function has been ascribed to this sequence. We previously found an in vivo double-strand break in omega - DNA at or close to the intron insertion site only in zygotes of omega + X omega - crosses that appears with the same kinetics as intron insertion. We now show that mutations in the intron open reading frame that would alter the translation product simultaneously inhibit nonreciprocal omega recombination and the in vivo double-strand break in omega - DNA. These results provide evidence that the open reading frame encodes a protein required for intron transposition and support the role of the double-strand break in the process.

Investigation of new techniques for aircraft navigation using the omega navigation

NASA Technical Reports Server (NTRS)

Baxa, E. G., Jr.

1978-01-01

An OMEGA navigation receiver with a microprocessor as the computational component was investigated. A version of the INTEL 4004 microprocessor macroassembler suitable for use on the CDC-6600 system and development of a FORTRAN IV simulator program for the microprocessor was developed. Supporting studies included development and evaluation of navigation algorithms to generate relative position information from OMEGA VLF phase measurements. Simulation studies were used to evaluate assumptions made in developing a navigation equation in OMEGA Line of Position (LOP) coordinates. Included in the navigation algorithms was a procedure for calculating a position in latitude/longitude given an OMEGA LOP fix. Implementation of a digital phase locked loop (DPLL) was evaluated on the basic of phase response characteristics over a range of input phase variations. Included also is an analytical evaluation on the basis of error probability of an algorithm for automatic time synchronization of the receiver to the OMEGA broadcast format. The use of actual OMEGA phase data and published propagation prediction corrections to determine phase velocity estimates was discussed.

Dissemination of CERN's Technology Transfer: Added Value from Regional Transfer Agents

ERIC Educational Resources Information Center

Hofer, Franz

2005-01-01

Technologies developed at CERN, the European Organization for Nuclear Research, are disseminated via a network of external technology transfer officers. Each of CERN's 20 member states has appointed at least one technology transfer officer to help establish links with CERN. This network has been in place since 2001 and early experiences indicate…

Simulation analysis of a microcomputer-based, low-cost Omega navigation system

NASA Technical Reports Server (NTRS)

Lilley, R. W.; Salter, R. J., Jr.

1976-01-01

The current status of research on a proposed micro-computer-based, low-cost Omega Navigation System (ONS) is described. The design approach emphasizes minimum hardware, maximum software, and the use of a low-cost, commercially-available microcomputer. Currently under investigation is the implementation of a low-cost navigation processor and its interface with an omega sensor to complete the hardware-based ONS. Sensor processor functions are simulated to determine how many of the sensor processor functions can be handled by innovative software. An input data base of live Omega ground and flight test data was created. The Omega sensor and microcomputer interface modules used to collect the data are functionally described. Automatic synchronization to the Omega transmission pattern is described as an example of the algorithms developed using this data base.

Enhanced sensitivity to the time variation of the fine-structure constant and m{p}/m{e} in diatomic molecules.

PubMed

Flambaum, V V; Kozlov, M G

2007-10-12

Sensitivity to temporal variation of the fundamental constants may be strongly enhanced in transitions between narrow close levels of different nature. This enhancement may be realized in a large number of molecules due to cancellation between the ground state fine-structure omega{f} and vibrational interval omega{v} [omega=omega{f}-nomega{v} approximately 0, delta omega/omega=K(2delta alpha/alpha+0.5 delta mu/mu), K>1, mu=m{p}/m{e}]. The intervals between the levels are conveniently located in microwave frequency range and the level widths are very small. Required accuracy of the shift measurements is about 0.01-1 Hz. As examples, we consider molecules Cl(+)(2), CuS, IrC, SiBr, and HfF(+).

Probing the dark energy with quasar clustering.

PubMed

Calvão, M O; de Mello Neto, J R T; Waga, I

2002-03-04

We show through Monte Carlo simulations that the Alcock-Paczyński test, as applied to quasar clustering, is a powerful tool to probe the cosmological density and equation of state parameters Omega(m0), Omega(x0), and w. By taking into account the effect of peculiar velocities upon the correlation function we obtain for the Two-Degree Field QSO Redshift Survey the predicted confidence contours for the cosmological constant (w = -1) and spatially flat (Omega(m0)+Omega(x0) = 1) cases. For w = -1, the test is especially sensitive to the difference Omega(m0)-Omega(Lambda0), thus being ideal to combine with cosmic microwave background results. For the flat case, it is competitive with future supernova and galaxy number count tests, besides being complementary to them.

Development of a Low-Cost Method for Whole-Spacecraft Isolation of Small Satellites

DTIC Science & Technology

2017-01-10

c*m1* omega (i)^ 3 *j + c*m2* omega (i)^ 3 *j); % Sff(i)=(1+( omega (i)/w2/Q)^2)/((1-( omega (i)/w2)^2)^2+( omega (i)/... w2/Q)^2)*ABC_MPE_full(i)*abs(H2(i))^2...Paperwork Reduction Project (0704-0188) Washington DC 20503. 1. AGENCY USE ONLY (Leave Blank) 2. REPORT DATE December 2015 3 . REPORT TYPE AND DATES COVERED... 3 Incorporating Isolators on NPSCuL 41 3.1 Design Updates to NPSCuL . . . . . . . . . . . . . . . . . . . . 41 3.2 Test Set-Up and Configurations

Implementation of an experimental program to investigate the performance characteristics of OMEGA navigation

NASA Technical Reports Server (NTRS)

Baxa, E. G., Jr.

1974-01-01

A theoretical formulation of differential and composite OMEGA error is presented to establish hypotheses about the functional relationships between various parameters and OMEGA navigational errors. Computer software developed to provide for extensive statistical analysis of the phase data is described. Results from the regression analysis used to conduct parameter sensitivity studies on differential OMEGA error tend to validate the theoretically based hypothesis concerning the relationship between uncorrected differential OMEGA error and receiver separation range and azimuth. Limited results of measurement of receiver repeatability error and line of position measurement error are also presented.

Baseline Omega-3 Index Correlates with Aggressive and Attention Deficit Disorder Behaviours in Adult Prisoners

PubMed Central

Meyer, Barbara J.; Byrne, Mitchell K.; Collier, Carole; Parletta, Natalie; Crawford, Donna; Winberg, Pia C.; Webster, David; Chapman, Karen; Thomas, Gayle; Dally, Jean; Batterham, Marijka; Farquhar, Ian; Martin, Anne-Marie; Grant, Luke

2015-01-01

Background There is emerging evidence that the supplementation of omega-3 contributes to a decrease in aggressive behaviour in prison populations. A challenge of such research is achieving statistical power against effect sizes which may be affected by the baseline omega-3 index. There are no published data on the blood omega-3 index with studies of this kind to assess the variability of the blood omega-3 index in conjunction with aggression and attention deficit assessments. Objective To determine if the variance of the omega-3 index is correlated with aggressive and attention deficit behaviour in a prison population. Design 136 adult male prisoners were recruited from South Coast Correctional Centre (SCCC), NSW Australia. A 7 point categorisation was used to quantify levels of aggressive behaviour (4 weeks) from individual SCCC case notes, whereby higher scores correspond to increasingly aggressive behaviour. Study participants completed the Aggression Questionnaire (AQ) and the Brown’s Attention Deficit Disorder Scales (BADDS), provided a blood sample for erythrocyte fatty acid analysis using gas chromatography and the omega-3 index was calculated. Results The baseline omega-3 index ranged from 2.3% to 10.3%, indicating that some participants already had substantial omega-3 intake, however a median of 4.7% indicated a lower overall omega-3 intake than the general Australian population. Assessment of aggressive and attention deficit behaviour shows that there were negative correlations between baseline omega-3 index and baseline aggression categorisation scores (r = −0.21, P = 0.016); total AQ score (r = −0.234, P = 0.011); Anger (r = -0.222 p = 0.016); Hostility AQ (r = −0.239, P = 0.009); indirect aggression (r = −0.188 p = 0.042); total BADDS (r = −0.263, p = 0.005); Activation (r = −0.224, p = 0.016); Attention (r = −0.192, p = 0.043); Effort (r = −0.253, p = 0.007); Affect (r = −0.330, p = 0.000) and Memory (r = −0.240, p = 0.010). Conclusions There is a high variability in omega-3 status of a NSW prison population, and inmates with lower omega-3 index were more aggressive and had higher ADD scores. PMID:25793501

Global, regional, and national consumption levels of dietary fats and oils in 1990 and 2010: a systematic analysis including 266 country-specific nutrition surveys.

PubMed

Micha, Renata; Khatibzadeh, Shahab; Shi, Peilin; Fahimi, Saman; Lim, Stephen; Andrews, Kathryn G; Engell, Rebecca E; Powles, John; Ezzati, Majid; Mozaffarian, Dariush

2014-04-15

To quantify global consumption of key dietary fats and oils by country, age, and sex in 1990 and 2010. Data were identified, obtained, and assessed among adults in 16 age- and sex-specific groups from dietary surveys worldwide on saturated, omega 6, seafood omega 3, plant omega 3, and trans fats, and dietary cholesterol. We included 266 surveys in adults (83% nationally representative) comprising 1,630,069 unique individuals, representing 113 of 187 countries and 82% of the global population. A multilevel hierarchical Bayesian model accounted for differences in national and regional levels of missing data, measurement incomparability, study representativeness, and sampling and modelling uncertainty. Global adult population, by age, sex, country, and time. In 2010, global saturated fat consumption was 9.4%E (95%UI=9.2 to 9.5); country-specific intakes varied dramatically from 2.3 to 27.5%E; in 75 of 187 countries representing 61.8% of the world's adult population, the mean intake was <10%E. Country-specific omega 6 consumption ranged from 1.2 to 12.5%E (global mean=5.9%E); corresponding range was 0.2 to 6.5%E (1.4%E) for trans fat; 97 to 440 mg/day (228 mg/day) for dietary cholesterol; 5 to 3,886 mg/day (163 mg/day) for seafood omega 3; and <100 to 5,542 mg/day (1,371 mg/day) for plant omega 3. Countries representing 52.4% of the global population had national mean intakes for omega 6 fat ≥ 5%E; corresponding proportions meeting optimal intakes were 0.6% for trans fat (≤ 0.5%E); 87.6% for dietary cholesterol (<300 mg/day); 18.9% for seafood omega 3 fat (≥ 250 mg/day); and 43.9% for plant omega 3 fat (≥ 1,100 mg/day). Trans fat intakes were generally higher at younger ages; and dietary cholesterol and seafood omega 3 fats generally higher at older ages. Intakes were similar by sex. Between 1990 and 2010, global saturated fat, dietary cholesterol, and trans fat intakes remained stable, while omega 6, seafood omega 3, and plant omega 3 fat intakes each increased. These novel global data on dietary fats and oils identify dramatic diversity across nations and inform policies and priorities for improving global health.

Reduced bone breakage and increased bone strength in free range laying hens fed omega-3 polyunsaturated fatty acid supplemented diets.

PubMed

Tarlton, John F; Wilkins, Lindsay J; Toscano, Michael J; Avery, Nick C; Knott, Lynda

2013-02-01

The omega-3 and omega-6 polyunsaturated fatty acids (PUFAs) are the immediate precursors to a number of important mediators of immunity, inflammation and bone function, with products of omega-6 generally thought to promote inflammation and favour bone resorption. Western diets generally provide a 10 to 20-fold deficit in omega-3 PUFAs compared with omega-6, and this is thought to have contributed to the marked rise in incidence of disorders of modern human societies, such as heart disease, colitis and perhaps osteoporosis. Many of our food production animals, fed on grains rich in omega-6, are also exposed to a dietary deficit in omega-3, with perhaps similar health consequences. Bone fragility due to osteoporotic changes in laying hens is a major economic and welfare problem, with our recent estimates of breakage rates indicating up to 95% of free range hens suffer breaks during lay. Free range hens housed in full scale commercial systems were provided diets supplemented with omega-3 alpha linolenic acid, and the skeletal benefits were investigated by comparison to standard diets rich in omega-6. There was a significant 40-60% reduction in keel bone breakage rate, and a corresponding reduction in breakage severity in the omega-3 supplemented hens. There was significantly greater bone density and bone mineral content, alongside increases in total bone and trabecular volumes. The mechanical properties of the omega-3 supplemented hens were improved, with strength, energy to break and stiffness demonstrating significant increases. Alkaline phosphatase (an osteoblast marker) and tartrate-resistant acid phosphatase (an osteoclast marker) both showed significant increases with the omega-3 diets, indicating enhanced bone turnover. This was corroborated by the significantly lower levels of the mature collagen crosslinks, hydroxylysyl pyridinoline, lysyl pyridinoline and histidinohydroxy-lysinonorleucine, with a corresponding significant shift in the mature:immature crosslink ratio. The improved skeletal health in laying hens corresponds to as many as 68million fewer hens suffering keel fractures in the EU each year. The biomechanical and biochemical evidence suggests that increased bone turnover has enhanced the bone mechanical properties, and that this may suggest potential benefits for human osteoporosis. Copyright © 2012 Elsevier Inc. All rights reserved.

Effects of eye drops containing a mixture of omega-3 essential fatty acids and hyaluronic acid on the ocular surface in desiccating stress-induced murine dry eye.

PubMed

Li, Zhengri; Choi, Jung-Han; Oh, Han-Jin; Park, Soo-Hyun; Lee, Jee-Bum; Yoon, Kyung Chul

2014-09-01

To investigate the efficacy of the topical application of omega-3 essential fatty acids (EFAs) and hyaluronic acid (HA) mixtures in a mouse model of experimental dry eye (EDE). Eye drops consisting of 0.1% HA, 0.02%, or 0.2% omega-3 EFAs alone and mixture of 0.02%, or 0.2% omega-3 EFAs and 0.1% HA were applied in desiccating stress-induced murine dry eye. Corneal irregularity scores and fluorescein staining scores were measured 5 and 10 days after treatment. Levels of interleukin (IL)-1β, -17, and interferon gamma-induced protein (IP)-10 were measured in the conjunctiva at 10 days using a multiplex immunobead assay. The concentrations of hexanoyl-lys (HEL) and 4-hydroxynonenal (4-HNE) in conjunctiva tissue were measured with enzyme-linked immunosorbent assays. Mice treated with the mixture containing 0.2% omega-3 EFAs showed a significant improvement in corneal irregularity scores and corneal fluorescein staining scores compared with EDE, HA, 0.02% or 0.2% omega-3 EFAs alone, and 0.02% omega-3 EFAs mixture-treated mice. A significant decrease in the levels of IL-1β, -17, and IP-10 were observed in the 0.2% EFAs mixture-treated group, compared with the other groups. In the mice treated with the mixture containing 0.2% omega-3 EFAs, the concentration of 4-HNE was also lower than the other groups. Although 0.2% omega-3 EFAs alone group also had a significant improvement in corneal irregularity scores and IL-17, IL-10, and 4 HNE levels compared with the other groups, the efficacy was lower than 0.2% omega-3 mixture group. Topically applied eye drops containing a mixture of omega-3 EFAs and HA could improve corneal irregularity and corneal epithelial barrier disruption, and decrease inflammatory cytokines and oxidative stress markers on the ocular surface. Topical omega-3 EFAs and HA mixture may have a greater therapeutic effect on clinical signs and inflammation of dry eye compared with HA artificial tears.

Observation of the {omega}{sub b}{sup -} baryon and measurement of the properties of the {xi}{sub b}{sup -} and {omega}{sub b}{sup -} baryons

DOE Office of Scientific and Technical Information (OSTI.GOV)

Aaltonen, T.; Maki, T.; Mehtala, P.

We report the observation of the bottom, doubly-strange baryon {omega}{sub b}{sup -} through the decay chain {omega}{sub b}{sup -}{yields}J/{psi}{omega}{sup -}, where J/{psi}{yields}{mu}{sup +}{mu}{sup -}, {omega}{sup -}{yields}{lambda}K{sup -}, and {lambda}{yields}p{pi}{sup -}, using 4.2 fb{sup -1} of data from pp collisions at {radical}(s)=1.96 TeV, and recorded with the Collider Detector at Fermilab. A signal is observed whose probability of arising from a background fluctuation is 4.0x10{sup -8}, or 5.5 Gaussian standard deviations. The {omega}{sub b}{sup -} mass is measured to be 6054.4{+-}6.8(stat){+-}0.9(syst) MeV/c{sup 2}. The lifetime of the {omega}{sub b}{sup -} baryon is measured to be 1.13{sub -0.40}{sup +0.53}(stat){+-}0.02(syst) ps. In addition,more » for the {xi}{sub b}{sup -} baryon we measure a mass of 5790.9{+-}2.6(stat){+-}0.8(syst) MeV/c{sup 2} and a lifetime of 1.56{sub -0.25}{sup +0.27}(stat){+-}0.02(syst) ps. Under the assumption that the {xi}{sub b}{sup -} and {omega}{sub b}{sup -} are produced with similar kinematic distributions to the {lambda}{sub b}{sup 0} baryon, we find ({sigma}({xi}{sub b}{sup -})B({xi}{sub b}{sup -}{yields}J/{psi}{xi}{sup -})/{sigma}({lambda}{sub b}{sup 0})B({lambda}{sub b}{sup 0}{yields}J/{psi}{lambda}))=0.167{sub -0.025}{sup +0.037}(stat){+-}0.012(syst) and ({sigma}({omega}{sub b}{sup -})B({omega}{sub b}{sup -}{yields}J/{psi}{omega}{sup -})/{sigma}({lambda}{sub b}{sup 0})B({lambda}{sub b}{sup 0}{yields}J/{psi}{lambda}))=0.045{sub -0.012}{sup +0.017}(stat){+-} 0.004(syst) for baryons produced with transverse momentum in the range of 6-20 GeV/c.« less

Omega-3 fatty acids as treatments for mental illness: which disorder and which fatty acid?

PubMed Central

Ross, Brian M; Seguin, Jennifer; Sieswerda, Lee E

2007-01-01

Background A growing number of observational and epidemiological studies have suggested that mental illness, in particular mood disorders, is associated with reduced dietary intake and/or cellular abundance of omega-3 polyunsaturated fatty acids (PUFA). This has prompted researchers to test the efficacy of omega-3 PUFA in a range of different psychiatric disorders. We have critically reviewed the double blind placebo controlled clinical trials published prior to April 2007 to determine whether omega-3 PUFA are likely to be efficacious in these disorders. Results Most trials involved a small number of participants but were largely well designed. Omega-3 PUFA were well tolerated by both children and adults with mild gastrointestinal effects being the only consistently reported adverse event. For schizophrenia and borderline personality disorder we found little evidence of a robust clinically relevant effect. In the case of attention deficit hyperactivity disorder and related disorders, most trials showed at most small benefits over placebo. A limited meta-analysis of these trials suggested that benefits of omega-3 PUFA supplementation may be greater in a classroom setting than at home. Some evidence indicates that omega-3 PUFA may reduce symptoms of anxiety although the data is preliminary and inconclusive. The most convincing evidence for beneficial effects of omega-3 PUFA is to be found in mood disorders. A meta-analysis of trials involving patients with major depressive disorder and bipolar disorder provided evidence that omega-3 PUFA supplementation reduces symptoms of depression. Furthermore, meta-regression analysis suggests that supplementation with eicosapentaenoic acid may be more beneficial in mood disorders than with docosahexaenoic acid, although several confounding factors prevented a definitive conclusion being made regarding which species of omega-3 PUFA is most beneficial. The mechanisms underlying the apparent efficacy of omega-3 PUFA in mood disorders compared to schizophrenia are discussed as is a rational for the possibly greater efficacy of EPA compared to DHA. Conclusion While it is not currently possible to recommend omega-3 PUFA as either a mono- or adjunctive-therapy in any mental illness, the available evidence is strong enough to justify continued study, especially with regard to attentional, anxiety and mood disorders. PMID:17877810

Effect of Oral Re-esterified Omega-3 Nutritional Supplementation on Dry Eyes.

PubMed

Epitropoulos, Alice T; Donnenfeld, Eric D; Shah, Zubin A; Holland, Edward J; Gross, Michael; Faulkner, William J; Matossian, Cynthia; Lane, Stephen S; Toyos, Melissa; Bucci, Frank A; Perry, Henry D

2016-09-01

To assess the effect of oral re-esterified omega-3 fatty acids on tear osmolarity, matrix metalloproteinase-9 (MMP-9), tear break-up time (TBUT), Ocular Surface Disease Index (OSDI), fluorescein corneal staining, Schirmer score, meibomian gland dysfunction (MGD) stage and omega-3 index in subjects with dry eyes and confirmed MGD. This was a multicenter, prospective, interventional, placebo-controlled, double-masked study. Subjects were randomized to receive 4 softgels containing a total of 1680 mg of eicosapentaenoic acid/560 mg of docosahexaenoic acid or a control of 3136 mg of linoleic acid, daily for 12 weeks. Subjects were measured at baseline, week 6, and week 12 for tear osmolarity, TBUT, OSDI, fluorescein corneal staining, and Schirmer test with anesthesia. MMP-9 testing and omega-3 index were done at baseline and at 12 weeks. One hundred five subjects completed the study. They were randomized to omega-3 (n = 54) and control group (n = 51). Statistically significant reduction in tear osmolarity was observed in the omega-3 group versus control group at week 6 (-16.8 ± 2.6 vs. -9.0 ± 2.7 mOsm/L, P = 0.042) and week 12 (-19.4 ± 2.7 vs. -8.3 ± 2.8 mOsm/L, P = 0.004). At 12 weeks, a statistically significant increase in omega-3 index levels (P < 0.001) and TBUT (3.5 ± 0.5 s vs. 1.2 ± 0.5 s, P = 0.002) was also observed. Omega-3 group experienced a significant reduction in MMP-9 positivity versus control group (67.9% vs. 35.0%, P = 0.024) and OSDI scores decreased significantly in omega-3 (-17.0 ± 2.6) versus control group (-5.0 ± 2.7, P = 0.002). Oral consumption of re-esterified omega-3 fatty acids is associated with statistically significant improvement in tear osmolarity, omega-3 index levels, TBUT, MMP-9, and OSDI symptom scores.

Whole blood omega-3 fatty acid concentrations are inversely associated with blood pressure in young, healthy adults.

PubMed

Filipovic, Mark G; Aeschbacher, Stefanie; Reiner, Martin F; Stivala, Simona; Gobbato, Sara; Bonetti, Nicole; Risch, Martin; Risch, Lorenz; Camici, Giovanni G; Luescher, Thomas F; von Schacky, Clemens; Conen, David; Beer, Juerg H

2018-07-01

Omega-3 fatty acids (n - 3 FA) may have blood pressure (BP)-lowering effects in untreated hypertensive and elderly patients. The effect of n - 3 FA on BP in young, healthy adults remains unknown. The Omega-3 Index reliably reflects an individuals' omega-3 status. We hypothesized that the Omega-3 Index is inversely associated with BP levels in young healthy adults. The current study (n = 2036) is a cross-sectional study investigating the baseline characteristics of a cohort, which includes healthy adults, age 25-41 years. Individuals with cardiovascular disease, known diabetes or a BMI higher than 35 kg/m were excluded. The Omega-3 Index was determined in whole blood using gas chromatography. Association with office and 24-h BP was assessed using multivariable linear regression models adjusted for potential confounders. Median Omega-3 Index was 4.58% (interquartile range 4.08; 5.25). Compared with individuals in the lowest Omega-3 Index quartile, individuals in the highest had a SBP and DBP that was 4 and 2 mmHg lower, respectively (P < 0.01). A significant linear inverse relationship of the Omega-3 Index with 24-h and office BP was observed. Per 1-U increase in log-transformed Omega-3 Index the lowering in BP (given as multivariable adjusted β coefficients; 95% confidence interval) was -2.67 mmHg (-4.83; -0.51; P = 0.02) and -2.30 mmHg (-3.92; -0.68; P = 0.005) for 24-h SBP and DBP, respectively. A higher Omega-3 Index is associated with statistically significant, clinically relevant lower SBP and DBP levels in normotensive young and healthy individuals. Diets rich in n - 3 FA may be a strategy for primary prevention of hypertension.

Sex Differences in Omega-3 and -6 Fatty Acids and Health Status Among Young Adults With Acute Myocardial Infarction: Results From the VIRGO Study.

PubMed

Lu, Yuan; Ding, Qinglan; Xu, Xiao; Spatz, Erica S; Dreyer, Rachel P; D'Onofrio, Gail; Caulfield, Michael; Nasir, Khurram; Spertus, John A; Krumholz, Harlan M

2018-05-30

Young women (aged ≤55 years) with acute myocardial infarction (AMI) have poorer health status outcomes than similarly aged men. Low omega-3 fatty acids (FAs) have been implicated as risk factors for cardiovascular outcomes in AMI patients, but it is not clear whether young women have similar or different post-AMI omega-3 FA profiles compared with young men. We assessed the sex differences in post-AMI omega-3 FAs and the associations of these biomarkers with patient-reported outcomes (symptom, functioning status, and quality of life) at 12-month follow-up, using data from 2985 US adults with AMI aged 18 to 55 years enrolled in the VIRGO (Variation in Recovery: Role of Gender on Outcomes of Young Acute Myocardial Infarction Patients) study. Biomarkers including eicosapentaenoic acid, docosahexaenoic acid, arachidonic acid (AA), eicosapentaenoic acid/AA ratio, omega-3/omega-6 ratio, and omega-3 index were measured 1 month after AMI. Overall, the omega-3 FAs and AA were similar in young men and women with AMI. In both unadjusted and adjusted analysis (controlling for age, sex, race, smoking, hypertension, diabetes mellitus, body mass index, and health status score at 1 month), omega-3 FAs and AA were not significantly associated with 12-month health status scores using the Bonferroni corrected statistical threshold. We found no evidence of sex differences in omega-3 FAs and AA in young men and women 1 month after AMI. Omega-3 FAs and AA at 1-month after AMI were generally not associated with 12-month patient-reported health status after adjusting for patient demographic, clinical characteristics, and the corresponding 1-month health status score. © 2018 The Authors and Quest Diagnostics Inc. Published on behalf of the American Heart Association, Inc., by Wiley.

The influence of vertical disparity gradient and cue conflict on EEG omega complexity in Panum's limiting case.

PubMed

Li, Huayun; Jia, Huibin; Yu, Dongchuan

2018-03-01

Using behavioral measures and ERP technique, researchers discovered at least two factors could influence the final perception of depth in Panum's limiting case, which are the vertical disparity gradient and the degree of cue conflict between two- and three-dimensional shapes. Although certain event-related potential components have been proved to be sensitive to the different levels of these two factors, some methodological limitations existed in this technique. In this study, we proposed that the omega complexity of EEG signal may serve as an important supplement of the traditional event-related potential technique. We found that the trials with lower vertical gradient disparity have lower omega complexity (i.e., higher global functional connectivity) of the occipital region, especially that of the right-occipital hemisphere. Moreover, for occipital omega complexity, the trials with low-cue conflict have significantly larger omega complexity than those with medium- and high-cue conflict. It is also found that the electrodes located in the middle line of the occipital region (i.e., POz and Oz) are more crucial to the impact of different levels of cue conflict on omega complexity than the other electrodes located in the left- and right-occipital hemispheres. These evidences demonstrated that the EEG omega complexity could reflect distinct neural activities evoked by Panum's limiting case configurations, with different levels of vertical disparity gradient and cue conflict. Besides, the influence of vertical disparity gradient and cue conflict on omega complexity may be regional dependent. NEW & NOTEWORTHY The EEG omega complexity could reflect distinct neural activities evoked by Panum's limiting case configurations with different levels of vertical disparity gradient and cue conflict. The influence of vertical disparity gradient and cue conflict on omega complexity is regional dependent. The omega complexity of EEG signal can serve as an important supplement of the traditional ERP technique.

Omega-3 fatty acids have antidepressant activity in forced swimming test in Wistar rats.

PubMed

Lakhwani, Lalit; Tongia, Sudheer K; Pal, Veerendra S; Agrawal, Rajendra P; Nyati, Prem; Phadnis, Pradeep

2007-01-01

Forced swimming test is used to induce a characteristic behavior of immobility in rats, which resembles depression in humans to some extent. We evaluated the effect of omega-3 fatty acids alone as well as compared it with the standard antidepressant therapy with fluoxetine in both acute and chronic studies. In both the studies, rats were divided into 4 groups and subjected to the following drug interventions - Group 1- control: Group 2- fluoxetine in dose of 10 mg/kg subcutaneously 23.5, 5 and 1 h before the test: Group 3- omega-3 fatty acids in dose of 500 mg/kg orally; Group 4- fluoxetine plus omega-3 fatty acids both. In acute study, omega-3 fatty acids were given in single dose 2 h prior to the test while in chronic study omega-3 fatty acids were given daily for a period of 28 days. All animals were subjected to a 15-min pretest followed 24 h later by a 5-min test. A time sampling method was used to score the behavioral activity in each group. The results revealed that in acute study, omega-3 fatty acids do not have any significant effect in forced swimming test. However, in chronic study, omega-3 fatty acids affect the immobility and swimming behavior significantly when compared with control (p < 0.01) without any significant effect on climbing behavior and the efficacy of combination of omega-3 fatty acids and fluoxetine is significantly more than that of fluoxetine alone in changing the behavioral activity of rats in forced swimming test. It leads to the conclusion that omega-3 fatty acids have antidepressant activity per se, and the combination of fluoxetine and omega-3 fatty acids has more antidepressant efficacy than fluoxetine alone in forced swimming test in Wistar rats.

Omega-3 supplements in pregnancy: are we too late to identify the possible benefits?

PubMed

Grigoriadis, Sophie; Barrett, Jon; Pittini, Richard; Herer, Elaine; Zaltz, Arthur; Bazinet, Richard P; Bradley, Lana; Kennedy, Sidney; Steiner, Meir; Levitt, Anthony

2010-03-01

Postpartum depression (PPD) is a common and recurring illness. Most women who experience PPD do not seek professional help; for those who do, the available treatment options are not supported by extensive research evidence. Several lines of research have linked omega-3 fatty acids (omega-3) supplementation with a reduced risk of PPD. Although it has been suggested that women in the perinatal period consume sufficient omega-3 to potentially prevent PPD, there is a lack of definitive research evidence. This pilot study surveyed pregnant women's current use of omega-3, multivitamin, and other supplements, as well as their attitudes toward omega-3 research during pregnancy, to assess the feasibility of pregnant women's participation in a large randomized controlled trial evaluating omega-3 supplementation. Women attending prenatal clinics over a three-week period were invited to participate in a survey. The survey contained an information letter that was followed by a brief questionnaire assessing the use of nutritional supplements and opinions regarding the likelihood of participating in a clinical trial during pregnancy. Of the 176 women who completed the survey, six women were in the first trimester of pregnancy, 82 were in the second trimester, and 87 were in the third trimester. One hundred fifty-nine respondents (90.3%) reported taking a multivitamin supplement but none were taking a supplement that contained omega-3; only 20 (11.4%) were taking omega-3. Seventy-eight women (44.4%) responded that they would participate in a clinical study evaluating the effects of fish oil on their health. The results of our study indicate that many pregnant women take prenatal multivitamins and nutritional supplements, that there are currently few pregnant women attending clinics at our hospitals who are supplementing with omega-3, and that pregnant women would be willing to participate in a clinical trial evaluating the effects of omega-3.

Role of Omega-3 Fatty Acids on Lipid Profile in Diabetic Dyslipidaemia: Single Blind, Randomised Clinical Trial.

PubMed

Chauhan, Shaylika; Kodali, Hanish; Noor, Jawad; Ramteke, Karuna; Gawai, Vidisha

2017-03-01

Diabetic dyslipidaemia is characterised by hypertriglyceridaemia, low High Density Lipoprotein (HDL), postprandial lipimea, small and dense LDL particles is considered to be a major predisposing factor for various macrovascular complications. Omega-3 fatty acids are fish oil derivative introduced in the market for dyslipidaemia associated with increased triglyceride level. To study the effect of omega-3 fatty acids on lipid profile in Type II diabetes patients. This study was prospective, single blind, randomized comparative trial. Hundred patients were randomized into three groups. Group I received metformin 500 mg twice daily and placebo, Group II received metformin 500 mg twice daily and omega-3 fatty acids (1 gram) once daily and the Group III received metformin 500 mg twice daily and omega-3 fatty acids (1 gram) twice daily. ANOVA test was applied for analysis. Group II was effective in reducing the triglyceride level from 144.59±14.18 mg/dl to 101±13.31 mg/dl which was significant as compared to Group I from 147.67±18.57 mg/dl to 145.8±19.86 mg/dl respectively. Group III containing 1 g of omega-3 fatty acids twice daily showed decrease from 144.83±22.17 mg/dl to 86±17.46 mg/dl and was more effective in reducing triglyceride levels than Group II containing 1 gram of omega-3 fatty acids once daily. Omega-3 fatty acids can be given in conjunction with metformin to reduce triglyceride levels in diabetic dyslipidaemia without any adverse drug reactions or any drug interaction. Omega-3 fatty acids were effective in reducing the triglyceride level significantly as compared to placebo. Two grams of omega-3 fatty acids were more effective than 1 gram of omega-3 fatty acids in reducing triglyceride levels.

High dietary ratio of omega-6 to omega-3 polyunsaturated acids during pregnancy and prevalence of post-partum depression.

PubMed

da Rocha, Camilla M M; Kac, Gilberto

2012-01-01

Observational studies suggest association between low concentrations of omega-3 family fatty acids and greater risk for post-partum depression (PPD). The objective was to investigate the effect of unbalanced dietary intake of omega-6/omega-3 ratio >9:1 in the prevalence for PPD. The study comprises a prospective cohort with four waves of follow-up during pregnancy and one following delivery. PPD was evaluated according to the Edinburgh Post-partum Depression Scale (PPD ≥ 11) in 106 puerperae between 2005 and 2007, in Rio de Janeiro, Brazil. Independent variables included socio-demographic, obstetric, pre-pregnancy body mass index (BMI) and dietary intake data, which were obtained by means of a food frequency questionnaire in the first trimester of pregnancy. Statistical analysis involved calculation of PPD prevalence and multivariate Poisson regression with robust variance. PPD prevalence amounted to 26.4% [n = 28; confidence interval (CI) 95%: 18.0-34.8], and higher prevalences of PPD were observed in women who consumed an omega-6/omega-3 ratio >9:1 (60.0%) and in those with pre-pregnancy BMI <18.5 kg/m(2) (66.7%). These variables held as factors associated to PPD in the multivariate model, elevating the chances of occurrence of the outcome in 2.50 (CI 95%: 1.21-5.14) and 4.01 times (CI 95%: 1.96-8.20), respectively. Analyses were adjusted for age, schooling, pre-pregnancy BMI, lipids consumption and time elapsed since delivery. It verified an association between omega-6/omega-3 ratio above 9:1, the levels recommended by the Institute of Medicine, and the prevalence of PPD. These results add to the evidence regarding the importance of omega-6 and omega-3 fatty acids in the regulation of mental health mechanisms. © 2010 Blackwell Publishing Ltd.

Scaling the CERN OpenStack cloud

NASA Astrophysics Data System (ADS)

Bell, T.; Bompastor, B.; Bukowiec, S.; Castro Leon, J.; Denis, M. K.; van Eldik, J.; Fermin Lobo, M.; Fernandez Alvarez, L.; Fernandez Rodriguez, D.; Marino, A.; Moreira, B.; Noel, B.; Oulevey, T.; Takase, W.; Wiebalck, A.; Zilli, S.

2015-12-01

CERN has been running a production OpenStack cloud since July 2013 to support physics computing and infrastructure services for the site. In the past year, CERN Cloud Infrastructure has seen a constant increase in nodes, virtual machines, users and projects. This paper will present what has been done in order to make the CERN cloud infrastructure scale out.

Pharmacological characterization of the voltage-dependent Ca2+ channels present in synaptosomes from rat and chicken central nervous system.

PubMed

Alvarez Maubecin, V; Sanchez, V N; Rosato Siri, M D; Cherksey, B D; Sugimori, M; Llinás, R; Uchitel, O D

1995-06-01

The voltage-dependent calcium channels present in mammalian and chicken brain synaptosomes were characterized pharmacologically using specific blockers of L-type channels (1,4-dihydropyridines), N-type channels (omega-conotoxin GVIA), and P-type channels [funnel web toxin (FTX) and omega-agatoxin IVA]. K(+)-induced Ca2+ uptake by chicken synaptosomes was blocked by omega-conotoxin GVIA (IC50 = 250 nM). This toxin at 5 microM did not block Ca2+ entry into rat frontal cortex synaptosomes. FTX and omega-agatoxin IVA blocked Ca2+ uptake by rat synaptosomes (IC50 = 0.17 microliter/ml and 40 nM, respectively). Likewise, in chicken synaptosomes, FTX and omega-agatoxin IVA affected Ca2+ uptake, FTX (3 microliters/ml) exerted a maximal inhibition of 40% with an IC50 similar to the one obtained in rat preparations, whereas with omega-agatoxin IVA saturation was not reached even at 5 microM. In chicken preparations, the combined effect of saturating concentrations of FTX (1 microliter/ml) and different concentrations of omega-conotoxin GVIA showed no additive effects. However, the effect of saturating concentrations of FTX and omega-conotoxin GVIA was never greater than the one observed with omega-conotoxin GVIA. We also found that 60% of the Ca2+ uptake by rat and chicken synaptosomes was inhibited by omega-conotoxin MVIID (1 microM), a toxin that has a high index of discrimination against N-type channels. Conversely, nitrendipine (10 microM) had no significant effect on Ca2+ uptake in either the rat or the chicken. In conclusion, Ca2+ uptake by rat synaptosomes is potently inhibited by different P-type Ca2+ channel blockers, thus indicating that P-type channels are predominant in this preparation.(ABSTRACT TRUNCATED AT 250 WORDS)

Electrical properties of toad sartorius muscle fibres in summer and winter.

PubMed

Dulhunty, A F; Gage, P W

1973-05-01

1. The area and circumference of surface fibres of sartorius muscles were measured from photomicrographs of frozen sections of whole muscles, and compared with the values obtained assuming a circular cross-section. The latter assumption gave an over-estimate of the mean area of 28%, but only a 2% over-estimate of the circumference. In isolated, single fibres, the assumption gave over-estimates of 25 and 6%, of area and circumference respectively.2. The passive electrical properties of fibres were different in summer and winter. The mean internal resistivity, membrane resistance and membrane capacitance were 147 Omega.cm, 7.6 kOmega.cm(2) and 4 muF/cm(2) in summer, and 194 Omega.cm, 3.9 kOmega.cm(2) and 6.7 muF/cm(2) in winter, in fibres of comparable diameters in situ. In single fibres in summer, the mean values were 120 Omega.cm, 8.6 kOmega.cm(2) and 3.6 muF/cm(2).3. In glycerol-treated fibres the mean specific membrane capacitance was 1.0 muF/cm(2) in summer and 2.0 muF/cm(2) in winter. The internal resistivity and specific membrane resistance were 167 Omega.cm and 8.9 kOmega.cm(2) in summer, and 232 Omega.cm and 3.9 kOmega.cm(2) in winter.4. Early after-depolarizations were recorded in glycerol-treated fibres which had a low membrane capacitance, did not twitch and showed little ;creep'. Electron micrographs of glycerol-treated fibres showed disruption of the transverse tubular system and sarcoplasmic reticulum.5. After exposure of muscles to 400 mM urea or acetamide for 1 hr, muscle fibres did not twitch and had a reduced membrane capacitance in Ringer solution.

High levels of omega-3 fatty acids in milk from omega-3 fatty acid-supplemented mothers are related to less immunoglobulin E-associated disease in infancy.

PubMed

Warstedt, Kristina; Furuhjelm, Catrin; Fälth-Magnusson, Karin; Fagerås, Malin; Duchén, Karel

2016-11-01

We previously reported a protective effect of maternal omega-3 fatty acid supplements on the development of immunoglobulin E (IgE)-associated disease in infancy. This study assessed omega-3 long-chain polyunsaturated fatty acids (LCPUFA) in maternal milk in relation to omega-3 LCPUFA supplementation and the development of allergic disease in their infants. This study randomised 95 pregnant women at risk of having an allergic infant, to daily supplements of 2.6 g omega-3 LCPUFA or a placebo of 2.7 g soya bean oil from gestational week 25 until 3 months of lactation. Breast milk samples were collected as colostrum, at one and 3 months. Milk fatty acids were related to allergic outcome in the infants at 24 months. Omega-3 milk fatty acids were higher in women who received omega-3 supplements than the placebo group (p < 0.01). Higher proportions of milk eicosapentaenoic acid and docosahexaenoic acid and a lower arachidonic/eicosapentaenoic acid ratio were associated with an absence of IgE-associated disease in the infants. None of the children developed IgE-associated atopic eczema above a level of 0.83 mol% eicosapentaenoic acid in colostrum. [Correction added on 7 July 2016, after online publication: In the preceding sentence, the correct word should be "above" instead of "below" and this has been amended in this current version.] CONCLUSION: High omega-3 LCPUFA milk levels in mothers who received omega-3 LCPUFA supplements were related to fewer allergies in their children. ©2016 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.

Omega 3 and 6 oils for primary prevention of allergic disease: systematic review and meta-analysis.

PubMed

Anandan, C; Nurmatov, U; Sheikh, A

2009-06-01

There is conflicting evidence on the use of omega 3 and omega 6 supplementation for the prevention of allergic diseases. We conducted a systematic review evaluating the effectiveness of omega 3 and 6 oils for the primary prevention of sensitization and development of allergic disorders. We searched The Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE, LILACS, PsycInfo, AMED, ISI Web of Science and Google Scholar for double-blind randomized controlled trials. Two authors independently assessed articles for inclusion. Meta-analyses were undertaken using fixed effects modelling, or random effects modelling in the event of detecting significant heterogeneity. Of the 3129 articles identified, 10 reports (representing six unique studies) satisfied the inclusion criteria. Four studies compared omega 3 supplements with placebo and two studies compared omega 6 supplements with placebo. There was no clear evidence of benefit in relation to reduced risk of allergic sensitization or a favourable immunological profile. Meta-analyses failed to identify any consistent or clear benefits associated with use of omega 3 [atopic eczema: RR = 1.10 (95% CI 0.78-1.54); asthma: RR = 0.81 (95% CI 0.53-1.25); allergic rhinitis: RR = 0.80 (95% CI 0.34-1.89) or food allergy RR = 0.51 (95% CI 0.10-2.55)] or omega 6 oils [atopic eczema: RR = 0.80 (95% CI 0.56-1.16)] for the prevention of clinical disease. Contrary to the evidence from basic science and epidemiological studies, our systematic review and meta-analysis suggests that supplementation with omega 3 and omega 6 oils is probably unlikely to play an important role as a strategy for the primary prevention of sensitization or allergic disease.

Omega-6 and omega-3 polyunsaturated fatty acid levels are reduced in whole blood of Italian patients with a recent myocardial infarction: the AGE-IM study.

PubMed

Marangoni, Franca; Novo, Giuseppina; Perna, Giampiero; Perrone Filardi, Pasquale; Pirelli, Salvatore; Ceroti, Marco; Querci, Andrea; Poli, Andrea

2014-02-01

The relationship between whole blood fatty acids and myocardial infarction (MI) risk has not been analyzed in detail, especially in Mediterranean countries. The AGE-IM (Acidi Grassi Essenziali e Infarto Miocardico) study was planned to examine the relationships between MI, whole blood fatty acids and the diet in an Italian cohort. 119 Patients with a recent MI and 103 control subjects were enrolled in the study. The whole blood fatty acid composition was determined; information on anthropometrics, biochemical parameters and blood pressure values were also obtained. Diet composition was assessed using a validated food frequency questionnaire from 86 cases and 72 controls. Total PUFA, omega-6 and omega-3 PUFA (as percentage of whole blood fatty acids) were significantly lower in MI patients than in matched controls, whereas saturated and monounsaturated fatty acids were higher in cases. MI infarction risk significantly and steadily decreased with increasing levels of total PUFA (OR: 0.14) and of total omega-6 and omega-3 (OR: 0.15 and 0.37, respectively). No correlation was identified between dietary fats and MI risk or between whole blood fatty acid levels and dietary nutrients and fats. Percentage levels of total PUFA, total omega-3 PUFA and total omega-6 PUFA are lower in MI patients than in matched control subjects in the AGE-IM cohort. These data support a favorable association not only of whole blood percentage levels of total omega-3, but also of total omega-6, with cardiovascular risk. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

Wavelength and pulselength dependence of laser conditioning and bulk damage in doubler-cut KH2PO4

DOE Office of Scientific and Technical Information (OSTI.GOV)

Adams, J J; Bruere, J R; Bolourchi, M

2005-10-28

An experimental technique has been utilized to measure the variation of bulk damage scatter with damaging fluence in plates of KH{sub 2}PO{sub 4} (KDP) crystals. Bulk damage in unconditioned and laser-conditioned doubler-cut KDP crystals has been studied using 527 nm (2{omega}) light at pulselengths of 0.3-10 ns. It is found that there is less scatter due to damage at fixed fluence for longer pulselengths. In particular, there is {approx}4X increase in fluence for equivalent scatter for damage at 2{omega}, 10 ns as compared to 0.30 ns in unconditioned KDP. The results for the unconditioned and conditioned KDP show that formore » all the pulselengths the scatter due to the bulk damage is a strong function of the damaging fluence ({phi}{sup -5}). It is determined that the 2{omega} fluence pulselength-scaling for equivalent bulk damage scatter in unconditioned KDP varies as {tau}{sup 0.30{+-}0.11} and in 3{omega}, 3ns ramp-conditioned KDP varies as {tau}{sup 0.27{+-}0.14}. The effectiveness of 2{omega} and 3{omega} laser conditioning at pulselengths in the range of 0.30-23 ns for damage induced 2{omega}, 3 ns is analyzed in terms of scatter. For the protocols tested (i.e. peak conditioning irradiance, etc.), the 3{omega}, 300 ps conditioning to a peak fluence of 3 J/cm{sup 2} had the best performance under 2{omega}, 3 ns testing. The general trend in the performance of the conditioning protocols was shorter wavelength and shorter pulselength appear to produce better conditioning for testing at 2{omega}, 3 ns.« less

Mapping QTL for Omega-3 Content in Hybrid Saline Tilapia.

PubMed

Lin, Grace; Wang, Le; Ngoh, Si Te; Ji, Lianghui; Orbán, Laszlo; Yue, Gen Hua

2018-02-01

Tilapia is one of most important foodfish species. The low omega-3 to omega-6 fatty acid ratio in freshwater tilapia meat is disadvantageous for human health. Increasing omega-3 content is an important task in breeding to increase the nutritional value of tilapia. However, conventional breeding to increase omega-3 content is difficult and slow. To accelerate the increase of omega-3 through marker-assisted selection (MAS), we conducted QTL mapping for fatty acid contents and profiles in a F 2 family of saline tilapia generated by crossing red tilapia and Mozambique tilapia. The total omega-3 content in F 2 hybrid tilapia was 2.5 ± 1.0 mg/g, higher than that (2.00 mg/g) in freshwater tilapia. Genotyping by sequencing (GBS) technology was used to discover and genotype SNP markers, and microsatellites were also genotyped. We constructed a linkage map with 784 markers (151 microsatellites and 633 SNPs). The linkage map was 2076.7 cM long and consisted of 22 linkage groups. Significant and suggestive QTL for total lipid content were mapped on six linkage groups (LG3, -4, -6, -8, -13, and -15) and explained 5.8-8.3% of the phenotypic variance. QTL for omega-3 fatty acids were located on four LGs (LG11, -18, -19, and -20) and explained 5.0 to 7.5% of the phenotypic variance. Our data suggest that the total lipid and omega-3 fatty acid content were determined by multiple genes in tilapia. The markers flanking the QTL for omega-3 fatty acids can be used in MAS to accelerate the genetic improvements of these traits in salt-tolerant tilapia.

Renal-protective and ameliorating impacts of omega-3 fatty acids against aspartame damaged MDCK cells.

PubMed

Pandurangan, Muthuraman; Enkhtaivan, Gansukh; Veerappan, Muthuviveganandavel; Mistry, Bhupendra; Patel, Rahul; Moon, So Hyun; Nagajyothi, Patnamsetty Chidanandha; Kim, Doo Hwan

2017-11-01

Aspartame is widely used artificial sweeteners as food additives. Several researchers have pointed that the controversial report on the use of aspartame over more than decades. Omega-3 fatty acids are essential and unsaturated fatty acids, and it plays a remarkable role in vision, intelligence, neural development, and metabolism of neurotransmitters. Therefore, the present study was aimed to investigate the effect of omega-3 fatty acids on aspartame treated renal cells. Experimental groups were divided into three such as sham control, aspartame treated, and aspartame with omega-3 fatty acids. Cell viability was determined by sulforhodamine-b assay and flow cytometric analysis. The experimental results showed that the aspartame induced altered cell viability were reduced following treatment of aspartame with omega-3 fatty acids. Altered cell morphology was recovered by omega-3 fatty acids. DNA damage appeared in the highest concentration of aspartame used in this study. DNA damage characteristics such as comet tail and tiny head sections did not appear in the omega-3 fatty acids treated cells. Several microvilli and vesicular structures were found in aspartame treated cells. Altered morphology such as rounding, microvilli, and formation of dome-like structures did not appear in the omega-3 fatty acids with aspartame treated cells. Caspase-3 mRNA and protein expression were increased in aspartame treated cells, and these levels were reduced following omega-3 fatty acids treatment. Taking all these data together, it is suggested that the omega-3 fatty acids may be a therapeutic agent to reduce the aspartame induced biochemical and morphological alterations in normal renal cells. © 2017 BioFactors, 43(6):847-857, 2017. © 2017 International Union of Biochemistry and Molecular Biology.

Galaxy Cluster Gas Mass Fractions From Sunyaev-Zeldovich Effect Measurements: Constraints on Omega(M)

NASA Technical Reports Server (NTRS)

Grego, Laura; Carlstrom, John E.; Reese, Erik D.; Holder, Gilbert P.; Holzapfel, William L.; Joy, Marshall K.; Mohr, Joseph J.; Patel, Sandeep

2001-01-01

Using sensitive centimeter-wave receivers mounted on the Owens Valley Radio Observatory and Berkeley-Illinois-Maryland-Association millimeter arrays, we have obtained interferometric measurements of the Sunyaev-Zeldovich(SZ) effect toward massive galaxy clusters. We use the SZ data to determine the pressure distribution of the cluster gas and, in combination with published X-ray temperatures, to infer the gas mass and total gravitational mass of 18 clusters. The gas mass fraction, f(g), is calculated for each cluster and is extrapolated to the fiducial radius r(500) using the results of numerical simulations. The mean f(g) within r(500) is 0.081(+ 0.009 / - 0.011) per h(100) (statistical uncertainty at 68% confidence level, assuming Omega(M) = 0.3, Omega(Lambda) = 0.7). We discuss possible sources of systematic errors in the mean f(sub g) measurement. We derive an upper limit for Omega(M) from this sample under the assumption that the mass composition of clusters within r(500) reflects the universal mass composition: Omega(M)h is less than or equal to Omega(B)/f(g). The gas mass fractions depend on cosmology through the angular diameter distance and the r(500) correction factors. For a flat universe (Omega(Lambda) is identical with 1 - Omega(M)) and h = 0.7, we find the measured gas mass fractions are consistent with Omega(M) is less than 0.40, at 68% confidence. Including estimates of the baryons contained in galaxies and the baryons which failed to become bound during the cluster formation process, we find Omega(M) is approximately equal to 0.25.

Absolute versus relative measures of plasma fatty acids and health outcomes: example of phospholipid omega-3 and omega-6 fatty acids and all-cause mortality in women.

PubMed

Miura, Kyoko; Hughes, Maria Celia B; Ungerer, Jacobus P J; Smith, David D; Green, Adèle C

2018-03-01

In a well-characterised community-based prospective study, we aimed to systematically assess the differences in associations of plasma omega-3 and omega-6 fatty acid (FA) status with all-cause mortality when plasma FA status is expressed in absolute concentrations versus relative levels. In a community sample of 564 women aged 25-75 years in Queensland, Australia, baseline plasma phospholipid FA levels were measured using gas chromatography. Specific FAs analysed were eicosapentaenoic acid, docosapentaenoic acid, docosahexaenoic acid, total long-chain omega-3 FAs, linoleic acid, arachidonic acid, and total omega-6 FAs. Levels of each FA were expressed in absolute amounts (µg/mL) and relative levels (% of total FAs) and divided into thirds. Deaths were monitored for 17 years and hazard ratios and 95% confidence intervals calculated to assess risk of death according to absolute versus relative plasma FA levels. In total 81 (14%) women died during follow-up. Agreement between absolute and relative measures of plasma FAs was higher in omega-3 than omega-6 FAs. The results of multivariate analyses for risk of all-cause mortality were generally similar with risk tending to inverse associations with plasma phospholipid omega-3 FAs and no association with omega-6 FAs. Sensitivity analyses examining effects of age and presence of serious medical conditions on risk of mortality did not alter findings. The directions and magnitude of associations with mortality of absolute versus relative FA levels were comparable. However, plasma FA expressed as absolute concentrations may be preferred for ease of comparison and since relative units can be deduced from absolute units.

New parenteral lipid emulsions for clinical use.

PubMed

Waitzberg, Dan L; Torrinhas, Raquel Susana; Jacintho, Thiago Manzoni

2006-01-01

Routine use of parenteral lipid emulsions (LE) in clinical practice began in 1961, with the development of soybean oil (SO) - based LE. Although clinically safe, experimental reports indicated that SO-based LE could exert a negative influence on immunological functions. Those findings were related to its absolute and relative excess of omega-6 polyunsaturated fatty acids (PUFA) and the low amount of omega-3 PUFA and also to its high PUFA content with an increased peroxidation risk. This motivated the development of new LE basically designed along the reduction of omega-6 PUFA and the omega-3 PUFA addition in order to obtain balanced levels of the omega-6/omega-3 ratio. The new LE for clinical use (available in Europe and South America) are differentiated by their content in polyunsaturated (omega-6 and omega-3), monounsaturated, and saturated fatty acids (FA), as well as FA source of their origin, including soy, coconut, olive, and fish oil. This article presents the new LE nutrition and energy functions but also its biochemical, metabolic, and immunomodulating aspects, according to their FA content. LE at 20% when infused from 1.0 to 2.0 g/kg body weight/day rates, either alone or in association with amino acids and glucose, are safe and well tolerated in routine clinical practice. LE combining SO with medium-chain triglycerides and/or olive oil have less omega-6 PUFA and are better metabolized, with less inflammatory and immunosuppressive effects than in relation to pure SO-based LE. The omega-3 PUFA used alone or as component of a new and complex LE (soy, MCT, olive and fish oil) has demonstrated anti-inflammatory and immunomodulatory effects.

Update on marine omega-3 fatty acids: management of dyslipidemia and current omega-3 treatment options.

PubMed

Weintraub, Howard

2013-10-01

Low-density lipoprotein cholesterol (LDL-C) is currently the primary target in the management of dyslipidemia, and statins are first-line pharmacologic interventions. Adjunct therapy such as niacins, fibrates, bile acid sequestrants, or cholesterol absorption inhibitors may be considered to help reduce cardiovascular risk. This review discusses the need for alternative adjunct treatment options and the potential place for omega-3 fatty acids as such. The cardiovascular benefits of fish consumption are attributed to the omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), and a variety of omega-3 fatty acid products are available with varied amounts of EPA and DHA. The product types include prescription drugs, food supplements, and medical foods sourced from fish, krill, algal and plant oils or purified from these oils. Two prescription omega-3 fatty acids are currently available, omega-3 fatty acid ethyl esters (contains both EPA and DHA ethyl esters), and icosapent ethyl (IPE; contains high-purity EPA ethyl ester). A pharmaceutical containing free fatty acid forms of omega-3 is currently in development. Omega-3 fatty acid formulations containing EPA and DHA have been shown to increase LDL-C levels while IPE has been shown to lower triglyceride levels without raising LDL-C levels, alone or in combination with statin therapy. In addition, recent studies have not been able to demonstrate reduced cardiovascular risk following treatment with fibrates, niacins, cholesterol absorption inhibitors, or omega-3 fatty acid formulations containing both EPA and DHA in statin-treated patients; thus, there remains a need for further cardiovascular outcomes studies for adjunct therapy. Copyright © 2013 The Author. Published by Elsevier Ireland Ltd.. All rights reserved.

Cardiovascular benefits of omega-3 fatty acids.

PubMed

von Schacky, Clemens; Harris, William S

2007-01-15

Cardiac societies recommend the intake of 1 g/day of the two omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) for cardiovascular disease prevention, treatment after a myocardial infarction, prevention of sudden death, and secondary prevention of cardiovascular disease. These recommendations are based on a body of scientific evidence that encompasses literally thousands of publications. Of four large scale intervention studies three also support the recommendations of these cardiac societies. One methodologically questionable study with a negative result led a Cochrane meta-analysis to a null conclusion. This null conclusion, however, has not swayed the recommendations of the cardiac societies mentioned, and has been refuted with good reason by scientific societies. Based on the scientific evidence just mentioned, we propose a new risk factor to be considered for sudden cardiac death, the omega-3 index. It is measured in red blood cells, and is expressed as a percentage of EPA + DHA of total fatty acids. An omega-3 index of >8% is associated with 90% less risk for sudden cardiac death, as compared to an omega-3 index of <4%. The omega-3 index as a risk factor for sudden cardiac death has striking similarities to LDL as a risk factor for coronary artery disease. Moreover, the omega-3 index reflects the omega-3 fatty acid status of a given individual (analogous to HbA1c reflecting glucose homeostasis). The omega-3 index can therefore be used as a goal for treatment with EPA and DHA. As is the case now for LDL, in the future, the cardiac societies might very well recommend treatment with EPA and DHA to become goal oriented (e.g. an omega-3 index>8%).

Particle Astrophysics after COBE- Blois 92- Summary Talk

NASA Astrophysics Data System (ADS)

Primack, J. R.

The IV Rencontres de Blois, on Particle Astrophysics, held at the Ch\\^ateau de Blois, June 15-20, 1992, was a meeting well-timed for a reconsideration of the issues in particle astrophysics in the light of the COBE discovery of the cosmic microwave background (CMB) fluctuations. This is a summary of what I thought were the most interesting things discussed at Blois: (1) The near-success of Cold Dark Matter (CDM) in predicting the COBE fluctuation amplitude, which favors the hypothesis that structure formed in the universe through gravitational collapse. (2) The indications that $\\Omega\\approx1$ and that the power spectrum has a little more power on supercluster and larger scales than CDM. These are suggested by the IRAS and CfA redshift surveys and POTENT galaxy peculiar velocity analysis, and also by the COBE data. (3) The consequent demise of CDM and the rise of hybrid schemes such as Cold+Hot Dark Matter (C+HDM). (4) The possible implications for neutrino masses and mixings, and for cosmology, of the recent results on solar neutrinos. (5) The first discovery of TeV $\\gamma$ rays from an extragalactic source, which was announced at Blois. I also summarize here a number of the exciting ongoing and planned experiments and observations discussed at Blois: CERN experiments on $\

Facts about polyunsaturated fats

MedlinePlus

... your risk for heart disease. Polyunsaturated fats include omega-3 and omega-6 fats. These are essential fatty ... so you can only get them from food. Omega-3 fatty acids are good for your heart in ...

Omega-3 Fatty Acids

MedlinePlus

Omega-3 fatty acids are used together with lifestyle changes (diet, weight-loss, exercise) to reduce the amount ... the blood in people with very high triglycerides. Omega-3 fatty acids are in a class of medications ...

Isolated-attosecond-pulse generation from asymmetric molecules with an {omega}+2{omega}/3 multicycle two-color field

DOE Office of Scientific and Technical Information (OSTI.GOV)

Li Qianguang; Department of Physics, Xiaogan University, Xiaogan 432000; Hong Weiyi

2010-05-15

The high harmonic generation from asymmetric molecules with an {omega}+2{omega}/3 multicycle bichromatic laser pulse has been investigated. It is shown that the ionization asymmetry in consecutive half optical cycles for asymmetric molecules is further enhanced since the 2{omega}/3 control laser pulse further enhances the amplitude of the ionization peak at the center of the laser pulse. The 2{omega}/3 control laser pulse also significantly enlarges the difference of the photon energies emitted from the ejected electron in the half optical cycle at the central laser pulse and its next half optical cycle. In addition, a broadband supercontinuum is produced in themore » plateau of the spectrum, from which an isolated 90-as pulse can be directly obtained.« less

Electromagnetic Tunneling and Resonances in Pseudochiral Omega Slabs

PubMed Central

Razzaz, Faroq; Alkanhal, Majeed A. S.

2017-01-01

This paper presents theoretical investigation of the electromagnetic wave tunneling and anomalous transmission around the trapped modes in a pseudochiral omega slab. The dispersion relation, the conditions of the trapped modes, and the evanescent wave coupling and tunneling in two different reciprocal pseudochiral omega slab structures are derived. The Berreman’s matrix method is applied to obtain the transmission coefficients across the pseudochiral omega slab. When the structure is perturbed, a resonance phenomenon is detected around the trapped modes. This resonance results in transmission anomalies (total transmission and total reflection) and dramatic field amplifications around the trapped modes. The number of the discrete trapped modes and then the resonance frequencies are prescribed by the parameters of the pseudochiral omega slab such as the value of the omega parameter and its orientation and the slab thickness. PMID:28165058

Effect of omega-3 and ascorbic acid on inflammation markers in depressed shift workers in Shahid Tondgoyan Oil Refinery, Iran: a randomized double-blind placebo-controlled study

PubMed Central

Khajehnasiri, Farahnaz; Mortazavi, Seyed Bagher; Allameh, Abdolamir; Akhondzadeh, Shahin

2013-01-01

The present study aimed to assess the effect of supplementation of omega-3 and/or vitamin C on serum interleukin-6 and high sensitivity C-reactive protein concentration and depression scores among shift workers in Shahid Tondgoyan oil refinery. The study design was randomized, double-blind, placebo-controlled, parallel trial. Totally 136 shift workers with a depression score ≥10 in 21-item Beck Depression Rating Scale were randomly assigned to receive omega-3 (180 mg eicosapentaenoate acid and 120 mg docosahexaenoic acid) or/and vitamin C 250 mg or placebo twice daily (with the same taste and shape as omega-3 and vitamin C) for 60 days in four groups. Depression score, interleukin-6 and high sensitivity C-reactive protein were measured at baseline and after 60 days. This study showed that supplementation of omega-3 plus vitamin C is associated with a decrease in depression score (p<0.05). Supplementation of omega-3 without vitamin C, is associated with a reduction in depression score (p<0.0001) and high sensitivity C-reactive protein concentration (p<0.01). Therefore omega-3 supplementation showed a better effect on reducing depression score and high sensitivity C-reactive protein, but supplementation of vitamin C along with omega-3 did not have significant effect on change in C-reactive protein level compared to omega-3 alone. (Registration number: IRCT201202189056N1) PMID:23874068

Effect of the omega-3 fatty acid plus vitamin E supplementation on subjective global assessment score, glucose metabolism, and lipid concentrations in chronic hemodialysis patients.

PubMed

Asemi, Zatollah; Soleimani, Alireza; Bahmani, Fereshteh; Shakeri, Hossein; Mazroii, Navid; Abedi, Fatemeh; Fallah, Melika; Mohammadi, Ali Akbar; Esmaillzadeh, Ahmad

2016-02-01

This study was conducted to determine the effects of omega-3 fatty acid plus vitamin E supplementation on subjective global assessment (SGA) score and metabolic profiles in chronic hemodialysis (HD) patients. This randomized double-blind placebo-controlled clinical trial was conducted among 120 chronic HD patients. Participants were randomly divided into four groups to receive: (i) 1250 mg/day omega-3 fatty acid containing 600 mg eicosapentaenoic acid and 300 mg docosahexaenoic acid + vitamin E placebo (n = 30), (ii) 400 IU/day vitamin E + omega-3 fatty acids placebo (n = 30), (iii) 1250 mg omega-3 fatty acids/day + 400 IU/day vitamin E (n = 30), and (iv) omega-3 fatty acids placebo + vitamin E placebo (n = 30) for 12 wk. Fasting blood samples were taken at baseline and after 12-wk intervention to measure metabolic profiles. Patients who received combined omega-3 fatty acids and vitamin E supplements compared with vitamin E, omega-3 fatty acids, and placebo had significantly decreased SGA score (p < 0.001), fasting plasma glucose (p = 0.01), serum insulin levels (p = 0.001), homeostasis model of assessment insulin resistance (p = 0.002), and improved quantitative insulin sensitivity check index (p = 0.006). Omega-3 fatty acids plus vitamin E supplementation for 12 wk among HD patients had beneficial effects on SGA score and metabolic profiles. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Hydrated Minerals in Circumpolar Terrains: Geographic Distribution, Mineralogical Composition and Possible Origins

NASA Astrophysics Data System (ADS)

Langevin, Y.; Poulet, F.; Fishbaugh, K. E.; Roach, L.; Vincendon, M.; Gondet, B.; Bibring, J.; Murchie, S.

2007-12-01

The nearly global mapping provided at a scale of a few km by the OMEGA Vis/NIR imaging spectrometer on board Mars Express revealed that hydrated minerals on Mars are mostly observed in ancient terrains (Bibring et al., 2005). These discoveries led to the conclusion that surface water on Mars was mainly present early in the history of the planet, and that Mars has remained cold and dry during the last 3 billion years (Bibring et al., 2006). The observation by OMEGA of a very strong calcium sulfate signature (most likely dominated by gypsum) within the boundaries of the Olympia Planitia Dune field (Langevin et al., 2005) is a major puzzle as this geological feature is at most a few 100 m.y. old. An independent analysis of the OMEGA data (Horgan et al. 2007) confirmed the results of Langevin et al. (2005), in particular the identification of gypsum as the dominant mineralogical hydrated species in the dune field. The extended region richest in gypsum (~ 60 km x 200 km) remained unresolved at a resolution of 1 km/pixel (Langevin et al., 2006). With its 20 m resolution, CRISM, the Vis/NIR imaging spectrometer on board MRO, secured the relationship between the gypsum signature and the dune field as well as its absence over the "basal unit" (only a few pixels wide in OMEGA data) which is exposed between the dune field and the ice (Roach et al., 2007). CRISM showed that the gypsum signatures were highest over dune crests and weakest over exposed bedrock. Mineralogical modeling of the CRISM and OMEGA spectra shows that Gypsum represents at least 60% of the dune material in the eastern part of the Olympia field and decreases towards the western part. This lower limit has been raised since then by accounting for aerosol contributions which reduce the strength of absorption bands. The low albedo (< 20%) requires significant intimate and/or intra- mixture of dark material. The low thermal inertia (Herkenhoff and Vasavada, 1999) is difficult to reconcile with morphologic evidence for induration (Schatz et al., 2006). Weaker occurrences of the 1.93 µm OH stretch band have been observed in other northern and southern circumpolar locations. Sulfates and hydrated oxides provide much better matches for these signatures than phyllosilicates. The formation of large amounts of hydrated sulfates in the relatively young northern circumpolar terrains requires a source of sulfur (already present in soils? volcanic activity?) as well as water, which most likely is provided by outflows from the nearby polar cap (Fishbaugh et al., 2007). This process for generating hydrated minerals is distinct from that which was active during the first few hundred million years of the history of the planet. Bibring et al., Science 307, p. 1576-1581 (2005); Bibring et al., Science 312, p. 400-404 (2006); Feldman et al., Lunar Planet. Sci. 38 #2311 (2007); Fishbaugh et al., J. Geophys. Res. 112, E07002 (2007); Herkenhoff and Vasavada, J. Geophys. Res. 104, 16484. Horgan et al., 7th Int. Conf. on Mars #3241 (2007); Langevin et al., Science 307, p. 1581-1583 ; Langevin et al., Lunar Planet. Sci. 36 #1652 (2005) ; Roach et al., Lunar Planet. Sci. 38 #1970 (2007) ; Schatz et al., J. Geophys. Res. 111, E04006 (2006).

Omega-3 Fatty Acids and Depression: Scientific Evidence and Biological Mechanisms

PubMed Central

Galvano, Fabio; Marventano, Stefano; Malaguarnera, Michele; Bucolo, Claudio; Drago, Filippo; Caraci, Filippo

2014-01-01

The changing of omega-6/omega-3 polyunsaturated fatty acids (PUFA) in the food supply of Western societies occurred over the last 150 years is thought to promote the pathogenesis of many inflammatory-related diseases, including depressive disorders. Several epidemiological studies reported a significant inverse correlation between intake of oily fish and depression or bipolar disorders. Studies conducted specifically on the association between omega-3 intake and depression reported contrasting results, suggesting that the preventive role of omega-3 PUFA may depend also on other factors, such as overall diet quality and the social environment. Accordingly, tertiary prevention with omega-3 PUFA supplement in depressed patients has reached greater effectiveness during the last recent years, although definitive statements on their use in depression therapy cannot be yet freely asserted. Among the biological properties of omega-3 PUFA, their anti-inflammatory effects and their important role on the structural changing of the brain should be taken into account to better understand the possible pathway through which they can be effective both in preventing or treating depression. However, the problem of how to correct the inadequate supply of omega-3 PUFA in the Westernized countries' diet is a priority in order to set food and health policies and also dietary recommendations for individuals and population groups. PMID:24757497

Development of food-grade nanoemulsions and emulsions for delivery of omega-3 fatty acids: opportunities and obstacles in the food industry.

PubMed

Walker, Rebecca; Decker, Eric A; McClements, David Julian

2015-01-01

Consumption of biologically active amounts of omega-3 fatty acids is linked to improved human health, which has partly been attributed to their important role in brain development and cardiovascular health. Western diets are relatively low in omega-3 fatty acids and many consumers turn to supplements or functional foods to increase their intake of these healthy lipids. Fish oil is one of the most widely used sources of omega-3 fatty acid for supplementation and has greater health benefits than plant sources because of its higher concentration of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). The incorporation of omega-3 fatty acids into foods and beverages is often challenging due to their low water-solubility, poor oxidative stability, and variable bioavailability. Nanoemulsions offer a promising way to incorporate omega-3 fatty acids into liquid food systems like beverages, dressing, sauces, and dips. Nanoemulsions are colloidal dispersions that contain small oil droplets (r<100 nm) that may be able to overcome many of the challenges of fortifying foods and beverages with omega-3 fatty acids. The composition and fabrication of nanoemulsions can be optimized to increase the chemical and physical stability of oil droplets, as well as to increase the bioavailability of omega-3 fatty acids.

The LHC timeline: a personal recollection (1980-2012)

NASA Astrophysics Data System (ADS)

Maiani, Luciano; Bonolis, Luisa

2017-12-01

The objective of this interview is to study the history of the Large Hadron Collider in the LEP tunnel at CERN, from first ideas to the discovery of the Brout-Englert-Higgs boson, seen from the point of view of a member of CERN scientific committees, of the CERN Council and a former Director General of CERN in the years of machine construction.

Effects of omega-3 fatty acid supplementation on mood and emotional information processing in recovered depressed individuals.

PubMed

Antypa, Niki; Smelt, August H M; Strengholt, Annette; Van der Does, A J Willem

2012-05-01

Beneficial effects of omega-3 fatty acids have been reported for several psychiatric disorders, particularly for depression. Association studies show a relationship between omega-3 intake and depression risk. Meta-analyses of clinical trials have shown a moderate effect of supplementation on depressive symptoms, but not on normal mood states. Few studies have investigated effects on cognition. The purpose of this study was to examine effects of omega-3 supplements on cognition and mood of recovered depressed individuals. Seventy-one participants were randomized to receive either omega-3 or placebo for four weeks in a randomized double-blind design. Results showed small effects of omega-3 supplementation on aspects of emotional decision-making and on self-reported states of depression and tension. Some of the effects were confounded by learning effects. No significant effects were observed on memory, attention, cognitive reactivity and depressive symptoms. While inconclusive, the present findings may indicate that omega-3 supplementation has selective effects on emotional cognition and mood in recovered depressed participants.

Time Correlations and the Frequency Spectrum of Sound Radiated by Turbulent Flows

NASA Technical Reports Server (NTRS)

Rubinstein, Robert; Zhou, Ye

1997-01-01

Theories of turbulent time correlations are applied to compute frequency spectra of sound radiated by isotropic turbulence and by turbulent shear flows. The hypothesis that Eulerian time correlations are dominated by the sweeping action of the most energetic scales implies that the frequency spectrum of the sound radiated by isotropic turbulence scales as omega(exp 4) for low frequencies and as omega(exp -3/4) for high frequencies. The sweeping hypothesis is applied to an approximate theory of jet noise. The high frequency noise again scales as omega(exp -3/4), but the low frequency spectrum scales as omega(exp 2). In comparison, a classical theory of jet noise based on dimensional analysis gives omega(exp -2) and omega(exp 2) scaling for these frequency ranges. It is shown that the omega(exp -2) scaling is obtained by simplifying the description of turbulent time correlations. An approximate theory of the effect of shear on turbulent time correlations is developed and applied to the frequency spectrum of sound radiated by shear turbulence. The predicted steepening of the shear dominated spectrum appears to be consistent with jet noise measurements.

Omega-3 free fatty acids attenuate insulin-promoted breast cancer cell proliferation.

PubMed

Guo, Yang; Zhu, Sheng-Long; Wu, Yi-Kuan; He, Zhao; Chen, Yong-Quan

2017-06-01

High insulin levels in obese people are considered as a risk factor to induce breast carcinogenesis. And consumption of fish oils which mainly contain omega-3 fatty acids is associated with a reduced risk of breast cancer. However, whether omega-3 free fatty acids (FFAs) modulate insulin signaling pathway to prevent breast cancer is poorly understood. The current study tested the hypothesis that omega-3 FFAs attenuate insulin-induced breast cancer cell proliferation and regulate insulin signaling pathway. We show here that omega-3 FFAs attenuate MCF-7 cell proliferation and Akt and Erk1/2 phosphorylation levels stimulated by insulin. Knockdown Shp2 by siRNA resulted in significantly elevated omega-3 FFAs-activated Akt phosphorylation but failed to change insulin-stimulated Akt and Erk1/2 phosphorylation. And viable cell number was not affected by either downregulation of Shp2 expression or Erk1/2 inhibitor U0126 treatment. These observations indicated that omega-3 FFAs attenuate insulin-promoted breast cancer cell proliferation and insulin-activated Akt phosphorylation. Copyright © 2017 Elsevier Inc. All rights reserved.

Omega-3 fatty acids: cardiovascular benefits, sources and sustainability.

PubMed

Lee, John H; O'Keefe, James H; Lavie, Carl J; Harris, William S

2009-12-01

The evidence for the cardioprotective nature of omega-3 fatty acids is abundant, and currently available data indicate that patients with known coronary heart disease should consume at least 1 g daily of long-chain omega-3 fatty acids from either oily fish or fish-oil supplements, and that individuals without disease should consume at least 250-500 mg daily. However, this area of research poses two questions. Firstly, which is the best source of omega-3 fatty acids-fish or fish-oil supplements? Secondly, are recommendations for omega-3 supplementation warranted in view of the rapid depletion of world fish stocks? The argument that eating fish is better than taking fish-oil supplements stems from the fact that several important nutrients, such as vitamin D, selenium, and antioxidants, are missing from the supplements. However, three major prevention trials have clearly indicated that omega-3 fatty acid capsules confer cardiovascular benefits and, therefore, that both are cardioprotective. Sustainable sources of omega-3 fatty acids will need to be identified if long-term cardiovascular risk reduction is to be achieved at the population level.

Microalgal biofactories: a promising approach towards sustainable omega-3 fatty acid production

PubMed Central

2012-01-01

Omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) provide significant health benefits and this has led to an increased consumption as dietary supplements. Omega-3 fatty acids EPA and DHA are found in animals, transgenic plants, fungi and many microorganisms but are typically extracted from fatty fish, putting additional pressures on global fish stocks. As primary producers, many marine microalgae are rich in EPA (C20:5) and DHA (C22:6) and present a promising source of omega-3 fatty acids. Several heterotrophic microalgae have been used as biofactories for omega-3 fatty acids commercially, but a strong interest in autotrophic microalgae has emerged in recent years as microalgae are being developed as biofuel crops. This paper provides an overview of microalgal biotechnology and production platforms for the development of omega-3 fatty acids EPA and DHA. It refers to implications in current biotechnological uses of microalgae as aquaculture feed and future biofuel crops and explores potential applications of metabolic engineering and selective breeding to accumulate large amounts of omega-3 fatty acids in autotrophic microalgae. PMID:22830315

40 CFR 721.10556 - Poly(oxy-1,2-ethanediyl), .alpha.- (2-methyl-2-propen-1-yl) -.omega.-hydroxy-,C12-15-alkyl ethers.

Code of Federal Regulations, 2013 CFR

2013-07-01

....- (2-methyl-2-propen-1-yl) -.omega.-hydroxy-,C12-16-alkyl ethers (PMN P-06-452; CAS No. 675869-05-3...-methyl-2-propen-1-yl) -.omega.-hydroxy-,C12-15-alkyl ethers. 721.10556 Section 721.10556 Protection of...-ethanediyl), .alpha.- (2-methyl-2-propen-1-yl) -.omega.-hydroxy-,C12-15-alkyl ethers. (a) Chemical substance...

40 CFR 721.10556 - Poly(oxy-1,2-ethanediyl), .alpha.- (2-methyl-2-propen-1-yl) -.omega.-hydroxy-,C12-15-alkyl ethers.

Code of Federal Regulations, 2014 CFR

2014-07-01

....- (2-methyl-2-propen-1-yl) -.omega.-hydroxy-,C12-16-alkyl ethers (PMN P-06-452; CAS No. 675869-05-3...-methyl-2-propen-1-yl) -.omega.-hydroxy-,C12-15-alkyl ethers. 721.10556 Section 721.10556 Protection of...-ethanediyl), .alpha.- (2-methyl-2-propen-1-yl) -.omega.-hydroxy-,C12-15-alkyl ethers. (a) Chemical substance...

40 CFR 721.10558 - Poly(oxy-1,2-ethanediyl), .alpha.- (2-methyl-2-propen-1-yl) -.omega.-hydroxy-,C12-16-alkyl ethers.

Code of Federal Regulations, 2013 CFR

2013-07-01

....- (2-methyl-2-propen-1-yl) -.omega.-hydroxy-,C12-16-alkyl ethers (PMN P-06-452; CAS No. 675869-05-3...-methyl-2-propen-1-yl) -.omega.-hydroxy-,C12-16-alkyl ethers. 721.10558 Section 721.10558 Protection of...-ethanediyl), .alpha.- (2-methyl-2-propen-1-yl) -.omega.-hydroxy-,C12-16-alkyl ethers. (a) Chemical substance...

40 CFR 721.10557 - Poly(oxy-1,2-ethanediyl), .alpha.- (2-methyl-2-propen-1-yl) -.omega.-hydroxy-,C10-16-alkyl ethers.

Code of Federal Regulations, 2014 CFR

2014-07-01

....- (2-methyl-2-propen-1-yl) -.omega.-hydroxy-,C12-16-alkyl ethers (PMN P-06-452; CAS No. 675869-05-3...-methyl-2-propen-1-yl) -.omega.-hydroxy-,C10-16-alkyl ethers. 721.10557 Section 721.10557 Protection of...-ethanediyl), .alpha.- (2-methyl-2-propen-1-yl) -.omega.-hydroxy-,C10-16-alkyl ethers. (a) Chemical substance...

40 CFR 721.10558 - Poly(oxy-1,2-ethanediyl), .alpha.- (2-methyl-2-propen-1-yl) -.omega.-hydroxy-,C12-16-alkyl ethers.

Code of Federal Regulations, 2014 CFR

2014-07-01

....- (2-methyl-2-propen-1-yl) -.omega.-hydroxy-,C12-16-alkyl ethers (PMN P-06-452; CAS No. 675869-05-3...-methyl-2-propen-1-yl) -.omega.-hydroxy-,C12-16-alkyl ethers. 721.10558 Section 721.10558 Protection of...-ethanediyl), .alpha.- (2-methyl-2-propen-1-yl) -.omega.-hydroxy-,C12-16-alkyl ethers. (a) Chemical substance...

40 CFR 721.10557 - Poly(oxy-1,2-ethanediyl), .alpha.- (2-methyl-2-propen-1-yl) -.omega.-hydroxy-,C10-16-alkyl ethers.

Code of Federal Regulations, 2013 CFR

2013-07-01

....- (2-methyl-2-propen-1-yl) -.omega.-hydroxy-,C12-16-alkyl ethers (PMN P-06-452; CAS No. 675869-05-3...-methyl-2-propen-1-yl) -.omega.-hydroxy-,C10-16-alkyl ethers. 721.10557 Section 721.10557 Protection of...-ethanediyl), .alpha.- (2-methyl-2-propen-1-yl) -.omega.-hydroxy-,C10-16-alkyl ethers. (a) Chemical substance...

Flight test and evaluation of Omega navigation in a general aviation aircraft. Volume 1: Technical

NASA Technical Reports Server (NTRS)

Howell, J. D.; Hoffman, W. C.; Hwoschinsky, P. V.; Wischmeyer, C. E.

1975-01-01

A low cost flight research program was conducted to evaluate the performance of differential Omega navigation in a general aviation aircraft. The flight program consisted of two distinct parts corresponding to the two major objectives of the study. The Wallops Flight Program was conducted to obtain Omega signal and phase data in the Wallops Flight Center vicinity to provide preliminary technical information and experience in preparation for a comprehensive NASA/FAA flight test program of an experimental differential Omega system. The Northeast Corridor Flight Program was conducted to examine Omega operational suitability and performance on low altitude area navigation (RNAV) routes for city-center to city-center VTOL commercial operations in the Boston-New York-Washington corridor. The development, execution and conclusions of the flight research program are discribed. The results of the study provide both quantitative and qualitative data on the Omega Navigation System under actual operating conditions.

Resonance frequency broadening of wave-particle interaction in tokamaks due to Alfvénic eigenmode

DOE Office of Scientific and Technical Information (OSTI.GOV)

Meng, Guo; Gorelenkov, Nikolai N.; Duarte, Vinicius N.

We use the guiding center code ORBIT to study the broadening of resonances and the parametric dependence of the resonance frequency broadening widthmore » $$\\Delta\\Omega$$ on the nonlinear particle trapping frequency $$\\omega_b$$ of wave-particle interaction with specific examples using realistic equilibrium DIII-D shot 159243 (Collins et al. 2016 Phys. Rev. Lett. 116 095001). When the mode amplitude is small, the pendulum approximation for energetic particle dynamics near the resonance is found to be applicable and the ratio of the resonance frequency width to the deeply trapped bounce frequency $$\\Delta\\Omega/\\omega_b$$ equals 4, as predicted by theory. Lastly, it is found that as the mode amplitude increases, the coefficient $$a=\\Delta\\Omega/\\omega_b$$ becomes increasingly smaller because of the breaking down of the nonlinear pendulum approximation for the wave-particle interaction.« less

Rare B Meson Decays With Omega Mesons

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhang, Lei; /Colorado U.

2006-04-24

Rare charmless hadronic B decays are particularly interesting because of their importance in understanding the CP violation, which is essential to explain the matter-antimatter asymmetry in our universe, and of their roles in testing the ''effective'' theory of B physics. The study has been done with the BABAR experiment, which is mainly designed for the study of CP violation in the decays of neutral B mesons, and secondarily for rare processes that become accessible with the high luminosity of the PEP-II B Factory. In a sample of 89 million produced B{bar B} pairs on the BABAR experiment, we observed themore » decays B{sup 0} {yields} {omega}K{sup 0} and B{sup +} {yields} {omega}{rho}{sup +} for the first time, made more precise measurements for B{sup +} {yields} {omega}h{sup +} and reported tighter upper limits for B {yields} {omega}K* and B{sup 0} {yields} {omega}{rho}{sup 0}.« less

Offshore Membrane Enclosure for Growing Algai (Omega) System for Biofuel Production, Wastewater Treatment, and CO2 Sequestration

NASA Technical Reports Server (NTRS)

Trent, Jonathan; Embaye, Tsegereda; Buckwalter, Patrick; Richardson, Tra-My; Kagawa, Hiromi; Reinsch, Sigrid

2010-01-01

We are developing Offshore Membrane Enclosures for Growing Algae (OMEGA). OMEGAs are closed photo-bioreactors constructed of flexible, inexpensive, and durable plastic with small sections of semi-permeable membranes for gas exchange and forward osmosis (FO). Each OMEGA modules is filled with municipal wastewater and provided with CO2 from coastal CO2 sources. The OMEGA modules float just below the surface, and the surrounding seawater provides structural support, temperature control, and mixing for the freshwater algae cultures inside. The salinity gradient from inside to outside drives forward osmosis through the patches of FO membranes. This concentrates nutrients in the wastewater, which enhances algal growth, and slowly dewaters the algae, which facilitates harvesting. The concentrated algal biomass is harvested for producing biofuels and fertilizer. OMEGA system cleans the wastewater released into the surrounding coastal waters and functions as a carbon sequestration system.

Resonance frequency broadening of wave-particle interaction in tokamaks due to Alfvénic eigenmode

DOE PAGES

Meng, Guo; Gorelenkov, Nikolai N.; Duarte, Vinicius N.; ...

2018-01-19

We use the guiding center code ORBIT to study the broadening of resonances and the parametric dependence of the resonance frequency broadening widthmore » $$\\Delta\\Omega$$ on the nonlinear particle trapping frequency $$\\omega_b$$ of wave-particle interaction with specific examples using realistic equilibrium DIII-D shot 159243 (Collins et al. 2016 Phys. Rev. Lett. 116 095001). When the mode amplitude is small, the pendulum approximation for energetic particle dynamics near the resonance is found to be applicable and the ratio of the resonance frequency width to the deeply trapped bounce frequency $$\\Delta\\Omega/\\omega_b$$ equals 4, as predicted by theory. Lastly, it is found that as the mode amplitude increases, the coefficient $$a=\\Delta\\Omega/\\omega_b$$ becomes increasingly smaller because of the breaking down of the nonlinear pendulum approximation for the wave-particle interaction.« less

Offshore Membrane Enclosures for Growing Algae (OMEGA: A System for Biofuel Production, Wastewater Treatment, and CO2 Sequestration

NASA Technical Reports Server (NTRS)

Trent, Jonathan; Embaye, Tsegereda; Buckwalter, Patrick; Richardson, Tra-My; Kagawa, Hiromi; Reinsch, Sigrid; Martis, Mary

2010-01-01

We are developing Offshore Membrane Enclosures for Growing Algae (OMEGA). OMEGAs are closed photo-bioreactors constructed of flexible, inexpensive, and durable plastic with small sections of semi-permeable membranes for gas exchange and forward osmosis (FO). Each OMEGA modules is filled with municipal wastewater and provided with CO2 from coastal CO2 sources. The OMEGA modules float just below the surface, and the surrounding seawater provides structural support, temperature control, and mixing for the freshwater algae cultures inside. The salinit7 gradient from inside to outside drives forward osmosis through the patches of FO membranes. This concentrates nutrients in the wastewater, which enhances algal growth, and slowly dewaters the algae, which facilitates harvesting. Thy concentrated algal biomass is harvested for producing biofuels and fertilizer. OMEGA system cleans the wastewater released into the surrounding coastal waters and functions as a carbon sequestration system.

Global, regional, and national consumption levels of dietary fats and oils in 1990 and 2010: a systematic analysis including 266 country-specific nutrition surveys

PubMed Central

Khatibzadeh, Shahab; Shi, Peilin; Fahimi, Saman; Lim, Stephen; Andrews, Kathryn G; Engell, Rebecca E; Powles, John; Ezzati, Majid

2014-01-01

Objectives To quantify global consumption of key dietary fats and oils by country, age, and sex in 1990 and 2010. Design Data were identified, obtained, and assessed among adults in 16 age- and sex-specific groups from dietary surveys worldwide on saturated, omega 6, seafood omega 3, plant omega 3, and trans fats, and dietary cholesterol. We included 266 surveys in adults (83% nationally representative) comprising 1 630 069 unique individuals, representing 113 of 187 countries and 82% of the global population. A multilevel hierarchical Bayesian model accounted for differences in national and regional levels of missing data, measurement incomparability, study representativeness, and sampling and modelling uncertainty. Setting and population Global adult population, by age, sex, country, and time. Results In 2010, global saturated fat consumption was 9.4%E (95%UI=9.2 to 9.5); country-specific intakes varied dramatically from 2.3 to 27.5%E; in 75 of 187 countries representing 61.8% of the world’s adult population, the mean intake was <10%E. Country-specific omega 6 consumption ranged from 1.2 to 12.5%E (global mean=5.9%E); corresponding range was 0.2 to 6.5%E (1.4%E) for trans fat; 97 to 440 mg/day (228 mg/day) for dietary cholesterol; 5 to 3,886 mg/day (163 mg/day) for seafood omega 3; and <100 to 5,542 mg/day (1,371 mg/day) for plant omega 3. Countries representing 52.4% of the global population had national mean intakes for omega 6 fat ≥5%E; corresponding proportions meeting optimal intakes were 0.6% for trans fat (≤0.5%E); 87.6% for dietary cholesterol (<300 mg/day); 18.9% for seafood omega 3 fat (≥250 mg/day); and 43.9% for plant omega 3 fat (≥1,100 mg/day). Trans fat intakes were generally higher at younger ages; and dietary cholesterol and seafood omega 3 fats generally higher at older ages. Intakes were similar by sex. Between 1990 and 2010, global saturated fat, dietary cholesterol, and trans fat intakes remained stable, while omega 6, seafood omega 3, and plant omega 3 fat intakes each increased. Conclusions These novel global data on dietary fats and oils identify dramatic diversity across nations and inform policies and priorities for improving global health. PMID:24736206

Effects of omega-3 fatty acid plus alpha-tocopherol supplementation on malnutrition-inflammation score, biomarkers of inflammation and oxidative stress in chronic hemodialysis patients.

PubMed

Asemi, Zatollah; Soleimani, Alireza; Shakeri, Hossein; Mazroii, Navid; Esmaillzadeh, Ahmad

2016-11-01

The current study was carried out to assess the effects of omega-3 fatty acid and alpha-tocopherol co-supplementation on malnutrition-inflammation score (MIS), biomarkers of inflammation and oxidative stress in chronic hemodialysis (HD) patients. In a randomized double-blind placebo-controlled clinical trial, 120 patients with chronic HD were included. Patients were randomly allocated into four groups to receive: (1) 1250 mg/day omega-3 fatty acid containing 600 mg EPA and 300 mg DHA + alpha-tocopherol placebo (n = 30); (2) 400 IU/day alpha-tocopherol + omega-3 fatty acids placebo (n = 30); (3) 1250 mg omega-3 fatty acids/day + 400 IU/day alpha-tocopherol (n = 30); and (4) omega-3 fatty acids placebo + alpha-tocopherol placebo (n = 30) for 12 weeks. After 12 weeks of intervention, all three groups of alpha-tocopherol only, individual omega-3 fatty acids, and combined omega-3 fatty acids and alpha-tocopherol experienced a significant improvements in MIS compared with the placebo group; however, improvements were much greater in the individual omega-3 fats (-1.4 ± 1.4) and combined omega-3 fats and alpha-tocopherol (-1.1 ± 2.3) groups compared with alpha-tocopherol group alone (-0.5 ± 1.7, P = 0.004). Furthermore, both individual and combined intervention with omega-3 fats and alpha-tocopherol led to a significant increase in plasma nitric oxide (NO) (combined group: +17.6 ± 29.3; alpha-tocopherol: +43.1 ± 36.3; omega-3 fats: +31.0 ± 40.0; and placebo: -0.5 ± 18.5 µmol/L, respectively, P < 0.001) and total antioxidant capacity (TAC) (+64.9 ± 113.6, +53.0 ± 144.6, +57.6 ± 157.8 and -69.9 ± 215.1 mmol/L, respectively, P = 0.004) levels. Overall, omega-3 fatty acids and alpha-tocopherol co-supplementation for 12 weeks among HD patients improved MIS, plasma NO and TAC levels. Future studies with longer duration of the intervention are needed to confirm the validity of our findings. CLINICAL REGISTRATION: www.irct.ir as IRCT201410245623N28.

Emulsified omega-3 fatty-acids modulate the symptoms of depressive disorder in children and adolescents: a pilot study.

PubMed

Trebatická, Jana; Hradečná, Zuzana; Böhmer, František; Vaváková, Magdaléna; Waczulíková, Iveta; Garaiova, Iveta; Luha, Ján; Škodáček, Igor; Šuba, Ján; Ďuračková, Zdeňka

2017-01-01

The prevalence of mood disorders in children is a growing global concern. Omega-3 fatty acids (FA) are emerging as a promising adjuvant therapy for depressive disorder (DD) in paediatric patients. The primary objective of this pilot, single-centre, randomized, double-blind controlled study was to compare the efficacy of an Omega-3 FA fish oil emulsion with a control oil emulsion alongside standard treatment for depressive symptoms in children and adolescents suffering from depressive disorder (DD) and mixed anxiety depressive disorder (MADD). 38 children (12 patients were treated and diagnosed for at least 1 month before enrolment, 26 patients were first-time diagnosed as DD) aged 11-17 years were randomised 1:1 to the intervention (Omega-3 FA, 19 patients) or active comparator (Omega-6 FA, 19 patients) groups. Children's depression inventory (CDI) ratings were performed at baseline, every 2 weeks for a 12-week intervention period and at 4-week post-intervention. 35 patients (17 in Omega-3 and 18 in Omega-6 groups) who completed the whole intervention period were evaluated. Patients from Omega-3 group were stratified according to diagnosis into two subgroups (DD-10/17 and mixed anxiety depressive disorder (MADD)-7/17 patients) and in the Omega-6 group into DD-10/18 and MADD-8/18 patients. Groups were evaluated separately. Differences between-groups were tested with the Student´s t test or non-parametric Mann-Whitney U test. Two-way ANOVA with repeated measures and Friedman test were used to analyse the Treatment effect for response in CDI score. p < 0.05 was considered significant in all statistical analyses. Significant reductions in CDI scores in 35 analysed patients who completed 12 weeks intervention were observed after 12 weeks of intervention only in the Omega-3 group (p = 0.034). After stratification to depressive disorder and mixed anxiety depressive disorder subgroups, the DD subgroup receiving the Omega-3 FA fish oil showed statistically greater improvement (score reduction after 8 week treatment of -9.1 CDI, p = 0.0001) when compared to the MADD subgroup (score reduction after 8 week treatment -4.24 CDI, p = 0.271). CDI scores were reduced in the Omega-3 group and the depression subgroup had greater improvement than the mixed depressive/anxiety group. An Omega-3 fatty acid rich fish oil emulsion may be an effective adjuvant supplement during the treatment of depressive disorders in children. Trial registration ISRCTN81655012.

Omega-3 Fatty Acid Biomarkers and Subsequent Depressive Symptoms

PubMed Central

Persons, Jane E.; Robinson, Jennifer G.; Ammann, Eric M.; Coryell, William H.; Espeland, Mark A.; Harris, William S.; Manson, JoAnn E.; Fiedorowicz, Jess G.

2014-01-01

Objective We sought to determine the relationship between the omega-3 fatty acid content of red blood cell membranes (RBC), in particular docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), and baseline and new-onset depressive symptoms in postmenopausal women. We secondarily sought to characterize the association between dietary omega-3 fatty acid intake and depressive symptomatology. Methods Study participants included 7,086 members of the Women's Health Initiative Memory Study (aged 63–81) who had an assessment of RBC omega-3 fatty acid concentrations at the baseline screening visit. Depressive symptoms at baseline and follow-up were characterized using the Burnam 8-item scale for depressive disorders (CES-D/DIS short form), and secondarily additionally inferred by antidepressant medication use. Results In multivariable-adjusted models, our primary exposure, RBC DHA+EPA, was not related to depressive symptoms by any measure at baseline or follow-up, nor were RBC total omega-3, DHA, or EPA (all p>0.2). In contrast, dietary intake of omega-3 was positively associated with depressive symptoms at baseline (adjusted OR 1.082, 95% C.I. 1.004–1.166; p=0.04 for dietary DHA+EPA and Burnam Score ≥ 0.06), although this generally did not persist at follow-up. Conclusion No relationship between RBC omega-3 levels and subsequent depressive symptoms was evident, and associations between dietary omega-3 and depressive symptoms were variable. Biomarkers of omega-3 status do not appear to be related to risk of new depression in post-menopausal women. PMID:24338726

Penetration and screening of perpendicularly launched electromagnetic waves through bounded supercritical plasma confined in multicusp magnetic field

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dey, Indranuj; Bhattacharjee, Sudeep

2011-02-15

The question of electromagnetic wave penetration and screening by a bounded supercritical ({omega}{sub p}>{omega} with {omega}{sub p} and {omega} being the electron-plasma and wave frequencies, respectively) plasma confined in a minimum B multicusp field, for waves launched in the k perpendicular B{sub o} mode, is addressed through experiments and numerical simulations. The scale length of radial plasma nonuniformity (|n{sub e}/({partial_derivative}n{sub e}/{partial_derivative}r)|) and magnetostatic field (B{sub o}) inhomogeneity (|B{sub o}/({partial_derivative}B{sub o}/{partial_derivative}r)|) are much smaller than the free space ({lambda}{sub o}) and guided wavelengths ({lambda}{sub g}). Contrary to predictions of plane wave dispersion theory and the Clemow-Mullaly-Allis (CMA) diagram, for a boundedmore » plasma a finite propagation occurs through the central plasma regions where {alpha}{sub p}{sup 2}={omega}{sub p}{sup 2}/{omega}{sup 2}{>=}1 and {beta}{sub c}{sup 2}={omega}{sub ce}{sup 2}/{omega}{sup 2}<<1({approx}10{sup -4}), with {omega}{sub ce} being the electron cyclotron frequency. Wave screening, as predicted by the plane wave model, does not remain valid due to phase mixing and superposition of reflected waves from the conducting boundary, leading to the formation of electromagnetic standing wave modes. The waves are found to satisfy a modified upper hybrid resonance (UHR) relation in the minimum B field and are damped at the local electron cyclotron resonance (ECR) location.« less

Reductions of intimate partner violence resulting from supplementing children with omega-3 fatty acids: A randomized, double-blind, placebo-controlled, stratified, parallel-group trial.

PubMed

Portnoy, Jill; Raine, Adrian; Liu, Jianghong; Hibbeln, Joseph R

2018-05-20

Omega-3 supplementation has been found to reduce externalizing behavior in children. Reciprocal models of parent-child behavior suggest that improving child behavior could lead to improvements in parent behavior, however no study has examined whether omega-3 supplementation in children could reduce intimate partner violence or child maltreatment by their adult caregivers. In this randomized, double-blind, placebo-controlled, stratified, parallel group trial, a community sample of children were randomized to receive either a fruit drink containing 1 gm of omega-3 fats (Smartfish Recharge; Omega-3 group, n = 100) or the same fruit drink without omega-3's (Placebo group, n = 100). Child participants, adult caregivers, and research staff were blinded to group assignment. Adult caregivers reported inter-partner and child-directed physical assault and psychological aggression at baseline, 6 months (end of treatment) and 12 months (6 months post-treatment) using the Conflicts Tactics Scale. Caregivers of children in the omega-3 group reported long-term reductions in psychological aggression in a group × time interaction. Improvements in adult psychological aggression were correlated with improvements in child externalizing behavior scores. No differences were reported for child maltreatment. This study is the first to show that omega-3 supplementation in children can reduce inter-partner psychological aggression among adult caregivers not receiving supplements. Findings suggest that improving child behavior through omega-3 supplementation could have long-term benefits to the family system as a whole. © 2018 Wiley Periodicals, Inc.

Galaxy Cluster Gas Mass Fractions From Sunyaev-Zel'dovich Effect Measurement: Constraints on Omega_M

NASA Technical Reports Server (NTRS)

Grego, Laura; Carlstrom, John E.; Reese, Erik D.; Holder, Gilbert P.; Holzapfel, William L.; Joy, Marshall K.; Mohr, Joseph J.; Patel, Sandeep; Rose, M. Franklin (Technical Monitor)

2001-01-01

Using sensitive centimeter-wave receivers mounted on the Owens Valley Radio Observatory and Berkeley-Illinois-Maryland-Association millimeter arrays, we have obtained interferometric measurements of the Sunyaev-Zei'dovich (SZ) effect toward massive galaxy clusters. We use the SZ data to determine the pressure distribution of the cluster gas and, in combination with published X-ray temperatures, to infer the gas mass and total gravitational mass of 18 clusters. The gas mass fraction, fg, is calculated for each cluster, and is extrapolated to the fiducial radius r_{500} using the results of numerical simulations. The mean f_g within r_{500} is 0.081 + 0.009 - 0.011/(h_{100} (statistical uncertainty at 68% confidence level, assuming OmegaM=0.3, OmegaL=0.7). We discuss possible sources of systematic errors in the mean f 9 measurement. We derive an upper limit for OmegaM from this sample under the assumption that the mass composition of clusters within r_{500} reflects the universal mass composition: Omega_M h

The Omega-3 Index and relative risk for coronary heart disease mortality: Estimation from 10 cohort studies.

PubMed

Harris, William S; Del Gobbo, Liana; Tintle, Nathan L

2017-07-01

A recent 19-cohort meta-analysis examined the relationships between biomarkers of omega-3 fatty acids and risk for coronary heart disease (CHD). That study did not, however, report hazard ratios (HRs) specifically as a function of erythrocyte eicosapentaenoic (EPA) plus docosahexaenoic (DHA) levels, a metric called the Omega-3 Index in which EPA + DHA content is expressed as a percent of total fatty acids. The Omega-3 Index has been used in several recent studies and is a validated biomarker of omega-3 fatty acid tissue levels, but additional data are needed to confirm (or refute) the originally-proposed clinical cut-points of <4% (higher risk) and 8%-12% (lower risk). The present study was therefore undertaken using published data from this meta-analysis to estimate HRs per 1-SD increase in the Omega-3 Index and median quintile values for this metric across 10 of the cohorts for which the needed data were available. The overall mean (SD) for the Omega-3 Index in these 10 cohort studies was 6.1% (2.1%), and the HR for a 1-SD increase was 0.85 (95% confidence interval, 0.80-0.91). Median quintile 1 and 5 levels were 4.2% vs. 8.3%, respectively. Based on these values, we estimate that risk for fatal CHD would have been reduced by about 30% moving from an Omega-3 Index of 4%-8%. These findings support the use of <4% and >8% as reasonable therapeutic targets for the Omega-3 Index. Copyright © 2017 Elsevier B.V. All rights reserved.

Omega-3 Supplementation and Loneliness-Related Memory Problems: Secondary Analyses Of A Randomized Controlled Trial

PubMed Central

Jaremka, Lisa M.; Derry, Heather M.; Bornstein, Robert; Prakash, Ruchika Shaurya; Peng, Juan; Belury, Martha A.; Andridge, Rebecca R.; Malarkey, William B.; Kiecolt-Glaser, Janice K.

2014-01-01

Objective Loneliness enhances risk for episodic memory declines over time. Omega-3 supplementation can improve cognitive function for people experiencing mild cognitive difficulties. Accordingly, we explored whether omega-3 supplementation would attenuate loneliness-related episodic memory problems. Methods Participants (N=138) from a parent randomized controlled trial (RCT) were randomized to the placebo, 1.25 grams/day of omega-3, or 2.50 grams/day of omega-3 conditions for a 4-month period. They completed a baseline loneliness questionnaire and a battery of cognitive tests both at baseline and at the end of the RCT. Results Controlling for baseline verbal episodic memory scores, lonelier people within the placebo condition had poorer verbal episodic memory post-supplementation, as measured by immediate (b = −0.28, t(117) = −2.62, p = .010) and long-delay (b = −.06, t(116) = −2.07, p = .040) free recall, than their less lonely counterparts. This effect was not observed in the 1.25 grams/day and 2.50 grams/day supplementation groups, all p values > .10. The plasma omega-6:omega-3 ratio data mirrored these results. There were no loneliness-related effects of omega-3 supplementation on short-delay recall or the other cognitive tests, all p values > .32. Conclusion These results suggest that omega-3 supplementation attenuates loneliness-related verbal episodic memory declines over time and support the utility of exploring novel interventions for treating episodic memory problems among lonely people. ClinicalTrials.gov identifier: NCT00385723 PMID:25264972

Dual-shank attachment design for omega seals

DOEpatents

Sattinger, Stanley S.

1978-01-01

An improved apparatus and process for attaching welded omega seal segments to reactor heads, standpipes, mechanisms, and plugs comprises a first shank in combination with a second shank to attach an omega seal at a metal-to-metal interface.

40 CFR 721.10214 - Poly(oxyalkylenediyl),.alpha.-substituted carbomonocycle-.omega.-substituted carbomonocycle...

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Poly(oxyalkylenediyl),.alpha... Poly(oxyalkylenediyl),.alpha.-substituted carbomonocycle-.omega.-substituted carbomonocycle (generic... identified generically as poly(oxyalkylenediyl),.alpha.-substituted carbomonocycle-.omega.-substituted...

40 CFR 721.10214 - Poly(oxyalkylenediyl),.alpha.-substituted carbomonocycle-.omega.-substituted carbomonocycle...

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 31 2011-07-01 2011-07-01 false Poly(oxyalkylenediyl),.alpha... Poly(oxyalkylenediyl),.alpha.-substituted carbomonocycle-.omega.-substituted carbomonocycle (generic... identified generically as poly(oxyalkylenediyl),.alpha.-substituted carbomonocycle-.omega.-substituted...

40 CFR 721.10214 - Poly(oxyalkylenediyl),.alpha.-substituted carbomonocycle-.omega.-substituted carbomonocycle...

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Poly(oxyalkylenediyl),.alpha... Poly(oxyalkylenediyl),.alpha.-substituted carbomonocycle-.omega.-substituted carbomonocycle (generic... identified generically as poly(oxyalkylenediyl),.alpha.-substituted carbomonocycle-.omega.-substituted...

40 CFR 721.10214 - Poly(oxyalkylenediyl),.alpha.-substituted carbomonocycle-.omega.-substituted carbomonocycle...

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 32 2012-07-01 2012-07-01 false Poly(oxyalkylenediyl),.alpha... Poly(oxyalkylenediyl),.alpha.-substituted carbomonocycle-.omega.-substituted carbomonocycle (generic... identified generically as poly(oxyalkylenediyl),.alpha.-substituted carbomonocycle-.omega.-substituted...

Silencing of omega-5 gliadins in transgenic wheat eliminates a major source of environmental variability and improves dough mixing properties of flour.

PubMed

Altenbach, Susan B; Tanaka, Charlene K; Seabourn, Bradford W

2014-12-24

The end-use quality of wheat flour varies as a result of the growth conditions of the plant. Among the wheat gluten proteins, the omega-5 gliadins have been identified as a major source of environmental variability, increasing in proportion in grain from plants that receive fertilizer or are subjected to high temperatures during grain development. The omega-5 gliadins also have been associated with the food allergy wheat-dependent exercise-induced anaphylaxis (WDEIA). Recently, transgenic lines with reduced levels of omega-5 gliadins were developed using RNA interference (RNAi). These lines make it possible to determine whether changes in the levels of omega-5 gliadins in response to environmental conditions and agronomic inputs may be responsible for changes in flour end-use quality. Two transgenic wheat lines and a non-transgenic control were grown under a controlled temperature regimen with or without post-anthesis fertilizer and the protein composition of the resulting flour was analyzed by quantitative two-dimensional gel electrophoresis (2-DE). In one transgenic line, all 2-DE spots identified as omega-5 gliadins were substantially reduced without effects on other proteins. In the other transgenic line, the omega-5 gliadins were absent and there was a partial reduction in the levels of the omega-1,2 gliadins and the omega-1,2 chain-terminating gliadins as well as small changes in several other proteins. With the exception of the omega gliadins, the non-transgenic control and the transgenic plants showed similar responses to the fertilizer treatment. Protein contents of flour were determined by the fertilizer regimen and were similar in control and transgenic samples produced under each regimen while both mixing time and mixing tolerance were improved in flour from transgenic lines when plants received post-anthesis fertilizer. The data indicate that omega-5 gliadins have a negative effect on flour quality and suggest that changes in quality with the growth environment may be due in part to alterations in the levels of the omega gliadins. Because a known food allergen and one of the major sources of environmentally-induced variation in wheat flour protein composition has been eliminated, the transgenic lines may yield flour with both improved end-use quality and more consistent functionality when grown in different locations.

Multiwire Thermocouples in Reversing Flow

NASA Technical Reports Server (NTRS)

Forney, L. J.; Fralick, G. C.

1995-01-01

Measurements are recorded for multiwire thermocouples consisting of either two or three wires of unequal diameters. Signals from the multiwire probe are recorded for a reversing gas flow with both a periodic temperature and time constant fluctuation. It is demonstrated that the reconstructed signal from the multiwire thermocouple requires no compensation provided omega/omega(sub 1) less than 2.3 for two wires or omega/omega(sub 1) less than 3.6 for three wires where omega(sub 1) (= 2(pi)f) is the natural frequency of the smaller wire based on the maximum gas velocity. The latter results were possible provided Fourier transformed data from the wires were used and knowledge of the gas velocity phase angle was available.

Omega-3 fatty acids in baked freshwater fish from south of Brazil.

PubMed

Andrade, A D; Visentainer, J V; Matsushita, M; de Souza, N E

1997-03-01

Lipid and fatty acid levels in the edible flesh of 17 baked freshwater fish from Brazil's southern region were determined. Analyses of fatty acids methyl esters were performed by gas chromatography. Palmitic acid (C16:0) was the predominant saturated fatty acid, accouting for 50-70% of total saturated acids. Linoleic acid (C18:2 omega 6), linolenic acid (C18:3 omega 3), and docosahexaenoic acid (C22:6 omega 3) were the predominant polyunsatured fatty acids (PUFA). The data revealed that species such as barbado, corvina, pintado, and truta were good sources of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), and that most freshwater fish examined were good sources of PUFA-omega 3.

Continued investigation of potential application of Omega navigation to civil aviation

NASA Technical Reports Server (NTRS)

Baxa, E. G., Jr.

1978-01-01

Major attention is given to an analysis of receiver repeatability in measuring OMEGA phase data. Repeatability is defined as the ability of two like receivers which are co-located to achieve the same LOP phase readings. Specific data analysis is presented. A propagation model is described which has been used in the analysis of propagation anomalies. Composite OMEGA analysis is presented in terms of carrier phase correlation analysis and the determination of carrier phase weighting coefficients for minimizing composite phase variation. Differential OMEGA error analysis is presented for receiver separations. Three frequency analysis includes LOP error and position error based on three and four OMEGA transmissions. Results of phase amplitude correlation studies are presented.

[Polymethylene derivatives of nucleic bases with omega-functional groups: VII. Cytotoxicity in the series of N-(2-oxocyclohexyl)-omega-oxoalkyl substituted purines and pyrimidines].

PubMed

Komissarov, V V; Volgareva, G M; Ol'shanskaia, Ia S; Chernyshova, M E; Zavalishina, L E; Frank, G A; Shtil', A A; Kritsyn, A M

2009-01-01

New polymethylene derivatives of nucleic bases with a beta-diketo function in the omega-position were obtained by alkylation of uracil, thymine, cytosine, hypoxanthine, adenine, and N(2)-isobutyryl guanine with 2-omega-chloroal-kanoyl)cyclohexanones. The physical and chemical characteristics of the compounds synthesized and their effect on the K562 and HCT116 tumor cell lines were studied.

40 CFR 721.9663 - Poly(oxy-1,2-ethanediyl), alpha, alpha′-[thiobis (1-oxo-3,1-propanediyl)]bis [omega-hydroxy-,bis...

Code of Federal Regulations, 2012 CFR

2012-07-01

..., alphaâ²-[thiobis (1-oxo-3,1-propanediyl)]bis [omega-hydroxy-,bis (C11-15 and C11-15-isoalkyl) ethers. 721... Substances § 721.9663 Poly(oxy-1,2-ethanediyl), alpha, alpha′-[thiobis (1-oxo-3,1-propanediyl)]bis [omega...′-[thiobis (1-oxo-3,1-propanediyl)]bis [omega-hydroxy-,bis(C11-15 and C11-15-isoalkyl) ethers (PMN P-97-497...

Forward-Backward asymmetry in $$\\Lambda_{b}$$ production and search for the $$\\Xi^{-}_{b}$$ and $$\\Omega^{-}_{b}$$ baryons in $$p\\bar{p}$$ collisions at $$\\sqrt{s} = 1.96$$ TeV

DOE Office of Scientific and Technical Information (OSTI.GOV)

Garcia Gonzalez, Jose Andres

We present a search for the heavy-flavor baryonsmore » $$\\Xi_{b}$$ (bsd) and $$\\Omega^{-}_{b}$$ in decays $$\\Xi^{-}_{b}$$→ J/ψ$$\\Xi^{-}_{b}$$ → J/ψΛπ-, J/ψ → μ + μ - and $$\\Omega^{-}_{b}$$ → J/ψ$$\\Omega^{-}_{b}$$ J/ψΛ $$K^{-}_{b}$$, J/ψ → μ + μ - respectively.« less

40 CFR 721.9663 - Poly(oxy-1,2-ethanediyl), alpha, alpha′-[thiobis (1-oxo-3,1-propanediyl)]bis [omega-hydroxy-,bis...

Code of Federal Regulations, 2014 CFR

2014-07-01

..., alphaâ²-[thiobis (1-oxo-3,1-propanediyl)]bis [omega-hydroxy-,bis (C11-15 and C11-15-isoalkyl) ethers. 721... Substances § 721.9663 Poly(oxy-1,2-ethanediyl), alpha, alpha′-[thiobis (1-oxo-3,1-propanediyl)]bis [omega...′-[thiobis (1-oxo-3,1-propanediyl)]bis [omega-hydroxy-,bis(C11-15 and C11-15-isoalkyl) ethers (PMN P-97-497...

40 CFR 721.9663 - Poly(oxy-1,2-ethanediyl), alpha, alpha′-[thiobis (1-oxo-3,1-propanediyl)]bis [omega-hydroxy-,bis...

Code of Federal Regulations, 2013 CFR

2013-07-01

..., alphaâ²-[thiobis (1-oxo-3,1-propanediyl)]bis [omega-hydroxy-,bis (C11-15 and C11-15-isoalkyl) ethers. 721... Substances § 721.9663 Poly(oxy-1,2-ethanediyl), alpha, alpha′-[thiobis (1-oxo-3,1-propanediyl)]bis [omega...′-[thiobis (1-oxo-3,1-propanediyl)]bis [omega-hydroxy-,bis(C11-15 and C11-15-isoalkyl) ethers (PMN P-97-497...

40 CFR 721.9663 - Poly(oxy-1,2-ethanediyl), alpha, alpha′-[thiobis (1-oxo-3,1-propanediyl)]bis [omega-hydroxy-,bis...

Code of Federal Regulations, 2011 CFR

2011-07-01

..., alphaâ²-[thiobis (1-oxo-3,1-propanediyl)]bis [omega-hydroxy-,bis (C11-15 and C11-15-isoalkyl) ethers. 721... Substances § 721.9663 Poly(oxy-1,2-ethanediyl), alpha, alpha′-[thiobis (1-oxo-3,1-propanediyl)]bis [omega...′-[thiobis (1-oxo-3,1-propanediyl)]bis [omega-hydroxy-,bis(C11-15 and C11-15-isoalkyl) ethers (PMN P-97-497...

40 CFR 721.10336 - Poly(oxy-1,2-ethanediyl), .alpha.-(1-oxo-2-propen-1-yl)-.omega.-([1,1′-biphenyl]-2-yloxy)-.

Code of Federal Regulations, 2012 CFR

2012-07-01

...-oxo-2-propen-1-yl)-.omega.-([1,1â²-biphenyl]-2-yloxy)-. 721.10336 Section 721.10336 Protection of...-ethanediyl), .alpha.-(1-oxo-2-propen-1-yl)-.omega.-([1,1′-biphenyl]-2-yloxy)-. (a) Chemical substance and...), .alpha.-(1-oxo-2-propen-1-yl)-.omega.-([1,1′-biphenyl]-2-yloxy)- (PMN P-04-1; CAS No. 72009-86-0) is...

40 CFR 721.10336 - Poly(oxy-1,2-ethanediyl), .alpha.-(1-oxo-2-propen-1-yl)-.omega.-([1,1′-biphenyl]-2-yloxy)-.

Code of Federal Regulations, 2014 CFR

2014-07-01

...-oxo-2-propen-1-yl)-.omega.-([1,1â²-biphenyl]-2-yloxy)-. 721.10336 Section 721.10336 Protection of...-ethanediyl), .alpha.-(1-oxo-2-propen-1-yl)-.omega.-([1,1′-biphenyl]-2-yloxy)-. (a) Chemical substance and...), .alpha.-(1-oxo-2-propen-1-yl)-.omega.-([1,1′-biphenyl]-2-yloxy)- (PMN P-04-1; CAS No. 72009-86-0) is...

40 CFR 721.10336 - Poly(oxy-1,2-ethanediyl), .alpha.-(1-oxo-2-propen-1-yl)-.omega.-([1,1′-biphenyl]-2-yloxy)-.

Code of Federal Regulations, 2013 CFR

2013-07-01

...-oxo-2-propen-1-yl)-.omega.-([1,1â²-biphenyl]-2-yloxy)-. 721.10336 Section 721.10336 Protection of...-ethanediyl), .alpha.-(1-oxo-2-propen-1-yl)-.omega.-([1,1′-biphenyl]-2-yloxy)-. (a) Chemical substance and...), .alpha.-(1-oxo-2-propen-1-yl)-.omega.-([1,1′-biphenyl]-2-yloxy)- (PMN P-04-1; CAS No. 72009-86-0) is...

40 CFR 721.9663 - Poly(oxy-1,2-ethanediyl), alpha, alpha′-[thiobis (1-oxo-3,1-propanediyl)]bis [omega-hydroxy-,bis...

Code of Federal Regulations, 2010 CFR

2010-07-01

..., alphaâ²-[thiobis (1-oxo-3,1-propanediyl)]bis [omega-hydroxy-,bis (C11-15 and C11-15-isoalkyl) ethers. 721... Substances § 721.9663 Poly(oxy-1,2-ethanediyl), alpha, alpha′-[thiobis (1-oxo-3,1-propanediyl)]bis [omega...′-[thiobis (1-oxo-3,1-propanediyl)]bis [omega-hydroxy-,bis(C11-15 and C11-15-isoalkyl) ethers (PMN P-97-497...

Efficacy of nutritional supplementation with omega-3 and omega-6 fatty acids in dry eye syndrome: a systematic review of randomized clinical trials.

PubMed

Molina-Leyva, Ignacio; Molina-Leyva, Alejandro; Bueno-Cavanillas, Aurora

2017-12-01

To critically appraise scientific evidence regarding the efficacy of nutritional supplementation with omega-3 and omega-6 fatty acids for the treatment of dry eye syndrome (DES). A systematic review of randomized clinical trials was performed. Two independent reviewers selected and analysed the scientific papers that met inclusion and exclusion criteria. Objective and subjective efficacy outcomes were assessed. The trials involved a total of 2591 patients in fifteen independent studies. All studies were published between 2005 and 2015. The supplements used were mostly omega-3 and omega-6 in different proportions. Subjective improvement was measured using mainly Ocular Surface Disease Index (OSDI) test and Dry Eye Severity Score (DESS) test: significant differences in favour of the experimental group were found in seven of the studies. The objective amelioration was assessed by lacrimal function parameters: Tear break-up time (TBUT) significantly increased in nine studies and Schirmer's test in four studies. We observed a discrete improvement in the parameters of tear function. Scientific evidence is not strong enough to systematically recommend the use of omega-3 and omega-6 fatty acids as a standalone treatment of DES independently from its aetiology. However, they could be considered as an effective alternative to topical treatment in patients with DES secondary to certain pathologies. © 2017 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.

Contribution of Golden Apple Snail Flour to Enhance Omega- 3 and Omega-6 Fatty Acids Contents in Weaning Food

NASA Astrophysics Data System (ADS)

Marsyha, D. D.; Wijayanti, H. S.; Nuryanto; Anjani, G.

2018-02-01

The case of undernourished children in Grobogan District (15.3%) is caused by children nutrients intake less than the Recommendation Dietary Allowance (RDA). To enhance children nutrients intake, be required formulation of weaning food using high-nutrient local food such as golden apple snail (Pomacea canaliculata). Golden apple snail flour contains high contents of zinc, iron, omega-3 and omega-6 fatty acids. This study aims to analyze the effect of golden apple snail flour substitution on nutrients content and organoleptic properties of weaning food (baby porridge). This is an experimental research by substitution of golden apple snail flour in the making of weaning food with four treatments of substitution (0%, 5%, 10%, 15%). Substitution of golden apple snails flour could affect the nutrient content levels of fat, zinc, iron (p=0.0001), carbohydrate (p=0.011), water (p=0.003), ash (p=0.001), omega-3 and omega-6 fatty acids. Whereas, it could not affect the content of energy (p=0.678), protein (p=0.129) and fiber (p=0.482). Furthermore, the substitution could affect the organoleptic properties include color, texture and taste (p=0.0001) while not for the aroma (p=0.798). Based on nutrient content analysis, substitution of golden apple snail flour could enhance the zinc, iron, omega-3 and omega-6 fatty acids contents of weaning food.

Omega-3 versus isoflavones in the control of vasomotor symptoms in postmenopausal women.

PubMed

Palacios, S; Lilue, M; Mejia, A; Menendez, C

2017-12-01

Determine the efficacy and tolerability of omega-3 fatty acids versus soybean isoflavones in reducing the vasomotor symptoms (VMSs) frequency in postmenopausal women. A randomized, prospective, two-arm study was performed in healthy postmenopausal women aged 45-65. The two arms were: two capsules/day of omega-3 (425 mg of omega-3/capsule) administered orally (n = 38) and two tablets/day of soybean isoflavones (54.4 mg of isoflavones/tablet) (n = 30), over 16 weeks. The mean baseline frequency of moderate and severe VMSs per week in the omega-3 group was 24.56 and 23.90, respectively, and 19.65 and 19.51 in the isoflavone group. After 4 months, the reduction in moderate and severe hot flashes with omega-3 was significant (p < .001), whereas in the case of isoflavones, there was a significant difference in severe (p = .02) hot flashes after 4 months, but not in moderate hot flashes (p = .077). Omega-3 did not demonstrate significant efficacy differences versus isoflavones over time. The use of omega-3 has a beneficial effect on hot flash reduction after 4 months of treatment. This is comparable to the benefits found with soybean isoflavones after 3-4 weeks and after 4 months in severe hot flash women, but higher than those found with soybean isoflavones in moderate symptom women.

Association between Blood Omega-3 Index and Cognition in Typically Developing Dutch Adolescents

PubMed Central

van der Wurff, Inge S. M.; von Schacky, Clemens; Berge, Kjetil; Zeegers, Maurice P.; Kirschner, Paul A.; de Groot, Renate H. M.

2016-01-01

The impact of omega-3 long-chain polyunsaturated fatty acids (LCPUFAs) on cognition is heavily debated. In the current study, the possible association between omega-3 LCPUFAs in blood and cognitive performance of 266 typically developing adolescents aged 13–15 years is investigated. Baseline data from Food2Learn, a double-blind and randomized placebo controlled krill oil supplementation trial in typically developing adolescents, were used for the current study. The Omega-3 Index was determined with blood from a finger prick. At baseline, participants finished a neuropsychological test battery consisting of the Letter Digit Substitution Test (LDST), D2 test of attention, Digit Span Forward and Backward, Concept Shifting Test and Stroop test. Data were analyzed with multiple regression analyses with correction for covariates. The average Omega-3 Index was 3.83% (SD 0.60). Regression analyses between the Omega-3 Index and the outcome parameters revealed significant associations with scores on two of the nine parameters. The association between the Omega-3 Index and both scores on the LDST (β = 0.136 and p = 0.039), and the number of errors of omission on the D2 (β = −0.053 and p = 0.007). This is a possible indication for a higher information processing speed and less impulsivity in those with a higher Omega-3 Index. PMID:26729157

A meta-analysis of placebo-controlled trials of omega-3 fatty acid augmentation in schizophrenia: Possible stage-specific effects.

PubMed

Chen, Alexander T; Chibnall, John T; Nasrallah, Henry A

2015-11-01

Omega-3 fatty acids have shown promise as an adjunctive treatment for schizophrenia. However, efficacy across studies has been inconsistent. We conducted a meta-analysis of published controlled studies with the goal of detecting different efficacy profiles at various stages of schizophrenia. An online search was conducted for randomized, double-blind, placebo-controlled clinical trials, and a meta-analysis was conducted. Ten studies met the criteria for inclusion. Among patients in the prodromal phase of schizophrenia, omega-3 supplementation reduced psychotic symptom severity and lowered conversion rates to first-episode psychosis. In patients with first-episode schizophrenia, omega-3 decreased nonpsychotic symptoms, required lower antipsychotic medication dosages, and improved early treatment response rates. Omega-3 had mixed results in patients with stable chronic schizophrenia, with only some patients experiencing significant benefits. Among patients with chronic schizophrenia, use of omega-3 fatty acids both by those experiencing acute exacerbations and those who had discontinued antipsychotic medications resulted in worsening of psychotic symptoms. The data suggest that omega-3 fatty acids may be efficacious in reducing clinical symptoms for patients in the earlier stages of schizophrenia (prodrome and first episode), while producing mixed results for patients in the chronic stages. Based on these results, omega-3 fatty acids would not be recommended for acute exacerbations in patients with chronic schizophrenia nor for relapse prevention after discontinuation of antipsychotics.

The Role for Dietary Omega-3 Fatty Acids Supplementation in Older Adults

PubMed Central

Molfino, Alessio; Gioia, Gianfranco; Fanelli, Filippo Rossi; Muscaritoli, Maurizio

2014-01-01

Optimal nutrition is one of the most important determinants of healthier ageing, reducing the risk of disability, maintaining mental and physical functions, and thus preserving and ensuring a better quality of life. Dietary intake and nutrient absorption decline with age, thus increasing the risk of malnutrition, morbidity and mortality. Specific nutrients, particularly long-chain omega-3 polyunsaturated fatty acids (PUFAs), might have the potential of preventing and reducing co-morbidities in older adults. Omega-3 PUFAs are able to modulate inflammation, hyperlipidemia, platelet aggregation, and hypertension. Different mechanisms contribute to these effects, including conditioning cell membrane function and composition, eicosanoid production, and gene expression. The present review analyzes the influence of omega-3 PUFAs status and intake on brain function, cardiovascular system, immune function, muscle performance and bone health in older adults. Omega-3 FAs may have substantial benefits in reducing the risk of cognitive decline in older people. The available data encourage higher intakes of omega-3 PUFAs in the diet or via specific supplements. More studies are needed to confirm the role of omega-3 FAs in maintaining bone health and preventing the loss of muscle mass and function associated with ageing. In summary, omega-3 PUFAs are now identified as potential key nutrients, safe and effective in the treatment and prevention of several negative consequences of ageing. PMID:25285409

Jovian Chromophore Characteristics from Multispectral HST Images

NASA Technical Reports Server (NTRS)

Strycker, Paul D.; Chanover, Nancy J.; Simon-Miller, Amy A.; Banfield, Don; Gierasch, Peter J.

2011-01-01

The chromophores responsible for coloring the jovian atmosphere are embedded within Jupiter's vertical aerosol structure. Sunlight propagates through this vertical distribution of aerosol particles, whose colors are defined by omega-bar (sub 0)(lambda), and we remotely observe the culmination of the radiative transfer as I/F(lambda). In this study, we employed a radiative transfer code to retrieve omega-bar (sub 0)(lambda) for particles in Jupiter's tropospheric haze at seven wavelengths in the near-UV and visible regimes. The data consisted of images of the 2008 passage of Oval BA to the south of the Great Red Spot obtained by the Wide Field Planetary Camera 2 on-board the Hubble Space Telescope. We present derived particle colors for locations that were selected from 14 weather regions, which spanned a large range of observed colors. All omega-bar (sub 0)(lambda) curves were absorbing in the blue, and omega-bar (sub 0)(lambda) increased monotonically to approximately unity as wavelength increased. We found accurate fits to all omega-bar (sub 0)(lambda) curves using an empirically derived functional form: omega-bar (sub 0)(lambda) = 1 A exp(-B lambda). The best-fit parameters for the mean omega-bar (sub 0)(lambda) curve were A = 25.4 and B = 0.0149 for lambda in units of nm. We performed a principal component analysis (PCA) on our omega-bar (sub 0)(lambda) results and found that one or two independent chromophores were sufficient to produce the variations in omega-bar (sub 0)(lambda). A PCA of I/F(lambda) for the same jovian locations resulted in principal components (PCs) with roughly the same variances as the omega-bar (sub 0)(lambda) PCA, but they did not result in a one-to-one mapping of PC amplitudes between the omega-bar (sub 0)(lambda) PCA and I/F(lambda) PCA. We suggest that statistical analyses performed on I/ F(lambda) image cubes have limited applicability to the characterization of chromophores in the jovian atmosphere due to the sensitivity of 1/ F(lambda) to horizontal variations in the vertical aerosol distribution.

Omega-3 fatty acids for major depressive disorder during pregnancy: results from a randomized, double-blind, placebo-controlled trial.

PubMed

Su, Kuan-Pin; Huang, Shih-Yi; Chiu, Tsan-Hung; Huang, Kuo-Cherh; Huang, Chieh-Liang; Chang, Hui-Chih; Pariante, Carmine M

2008-04-01

Perinatal depression is common, and treatment remains challenging. Depression has been reported to be associated with the abnormality of omega-3 polyunsaturated fatty acids (PUFAs). A profound decrease of omega-3 PUFAs in the mother during pregnancy is associated with the higher demand of fetal development and might precipitate the occurrence of depression. In this study, we examined the efficacy of omega-3 PUFA monotherapy for the treatment of depression during pregnancy. From June 2004 to June 2006, we conducted an 8-week, double-blind, placebo-controlled trial comparing omega-3 PUFAs (3.4 g/d) with placebo in pregnant women with major depressive disorder (DSM-IV criteria). No psychotropic agent was given 1 month prior to or during the study period. The Hamilton Rating Scale for Depression (HAM-D) was scored every other week as the primary measurement of efficacy, while the Edinburgh Postnatal Depression Scale (EPDS) and Beck Depression Inventory (BDI) were secondary measures. Thirty-six subjects were randomly assigned to either omega-3 PUFAs or placebo, and 33 among them were evaluated in more than 2 visits. A total of 24 subjects completed the study. As compared to the placebo group, subjects in the omega-3 group had significantly lower HAM-D scores at weeks 6 (p = .001) and 8 (p = .019), a significantly higher response rate (62% vs. 27%, p = .03), and a higher remission rate, although the latter did not reach statistical significance (38% vs. 18%, p = .28). At the study end point, subjects in the omega-3 group also had significantly lower depressive symptom ratings on the EPDS and BDI. The omega-3 PUFAs were well tolerated and there were no adverse effects on the subjects and newborns. Omega-3 PUFAs may have therapeutic benefits in depression during pregnancy. In regard to the safety issue and psychotherapeutic effect, as well as health promotion to mothers and their newborns, it is worthy to conduct replication studies in a larger sample with a broad regimen of omega-3 PUFAs in pregnant women with depression. clinicaltrials.gov Identifier: NCT00618865.

Red blood cell membrane omega-3 fatty acid levels and physical performance: Cross-sectional data from the MAPT study.

PubMed

Fougère, Bertrand; de Souto Barreto, Philipe; Goisser, Sabine; Soriano, Gaëlle; Guyonnet, Sophie; Andrieu, Sandrine; Vellas, Bruno

2018-08-01

Studies have shown that omega-3 polyunsaturated fatty acids (PUFAs) are associated with brain, cardiovascular and immune function, as well as physical performance and bone health in older adults. So far, few studies have highlighted the associations between PUFA status and performance-based tests of physical function. To study the associations between the omega-3 index (red blood cell (RBC) membrane content of omega-3 PUFAs, such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)) and physical performance measured with the Short Physical Performance Battery (SPPB) in a sample of community-dwelling older adults. Cross-sectional study using the baseline data of the Multidomain Alzheimer's Disease Trial (MAPT), a randomized, placebo-controlled trial. 1449 participants with available data on PUFAs were included. Omega-3 index and Short Physical Performance Battery (SPPB) scores were measured at enrollment and the omega-3 index expressed as the percentage of total fatty acid content was calculated. We also dichotomized the omega-3 index as low (lowest quartile) vs. high (three upper quartiles). Participants were 75.2 (±4.4) years old, 64.5% were female. Bivariate analyses found that participants who were in the lowest omega-3 index quartile (Q1) had a SPPB score significantly lower than participants in the three other quartiles (Q2-Q4). However, adjusted (for age, gender, cognitive function, depressive status, Body Mass Index and grip strength) multiple linear regression showed that the omega-3 index-SPPB score association did not reach statistical significance [β = -0.166; (-0.346; 0.013); p = 0.07] in our sample. This cross-sectional study found that participants with a low omega-3 index had worse performance-based test results of physical function than people with a high omega-3 index, but this association did not reach statistical significance once confounders were controlled for. Studies looking at the over-time associations between PUFA status and physical performance changes may shed more light on this topic. Copyright © 2017 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.

Role of Omega-3 Fatty Acids in the Treatment of Depressive Disorders: A Comprehensive Meta-Analysis of Randomized Clinical Trials

PubMed Central

Grosso, Giuseppe; Pajak, Andrzej; Marventano, Stefano; Castellano, Sabrina; Galvano, Fabio; Bucolo, Claudio; Drago, Filippo; Caraci, Filippo

2014-01-01

Background Despite omega-3 polyunsaturated fatty acids (PUFA) supplementation in depressed patients have been suggested to improve depressive symptomatology, previous findings are not univocal. Objectives To conduct an updated meta-analysis of randomized controlled trials (RCTs) of omega-3 PUFA treatment of depressive disorders, taking into account the clinical differences among patients included in the studies. Methods A search on MEDLINE, EMBASE, PsycInfo, and the Cochrane Database of RCTs using omega-3 PUFA on patients with depressive symptoms published up to August 2013 was performed. Standardized mean difference in clinical measure of depression severity was primary outcome. Type of omega-3 used (particularly eicosapentaenoic acid [EPA] and docosahexaenoic acid [DHA]) and omega-3 as mono- or adjuvant therapy was also examined. Meta-regression analyses assessed the effects of study size, baseline depression severity, trial duration, dose of omega-3, and age of patients. Results Meta-analysis of 11 and 8 trials conducted respectively on patients with a DSM-defined diagnosis of major depressive disorder (MDD) and patients with depressive symptomatology but no diagnosis of MDD demonstrated significant clinical benefit of omega-3 PUFA treatment compared to placebo (standardized difference in random-effects model 0.56 SD [95% CI: 0.20, 0.92] and 0.22 SD [95% CI: 0.01, 0.43], respectively; pooled analysis was 0.38 SD [95% CI: 0.18, 0.59]). Use of mainly EPA within the preparation, rather than DHA, influenced final clinical efficacy. Significant clinical efficacy had the use of omega-3 PUFA as adjuvant rather than mono-therapy. No relation between efficacy and study size, baseline depression severity, trial duration, age of patients, and study quality was found. Omega-3 PUFA resulted effective in RCTs on patients with bipolar disorder, whereas no evidence was found for those exploring their efficacy on depressive symptoms in young populations, perinatal depression, primary disease other than depression and healthy subjects. Conclusions The use of omega-3 PUFA is effective in patients with diagnosis of MDD and on depressive patients without diagnosis of MDD. PMID:24805797

MicrOmega IR: a new infrared hyperspectral imaging microscope or in situ analysis

NASA Astrophysics Data System (ADS)

Vaitua, Leroi; Bibring, Jean-Pierre; Berthé, Michel

2017-11-01

MicrOmega IR is an ultra miniaturized Near Infrared hyperspectral microscope for in situ analysis of samples. It is designed to be implemented on board space planetary vehicles (lander and/or rovers). It acquires images of samples typically some 5 mm in width with a spatial sampling of 20 μm. On each pixel, MicrOmega acquires the spectrum in the spectral range 0.9 - 2.6 μm, with a possibility to extend the sensibility up to 4 μm. The spectrum will be measured in up to 300 contiguous spectral channels (600 in the extended range): given the diagnostic spectral features present in this domain, it provides the composition of each spatially resolved constituent. MicrOmega has thus the potential to identify: minerals, such as pyroxene and olivine, ferric oxides, hydrated phases such as phyllosilicates, sulfates and carbonates, ices and organics. The composition of the various phases within a given sample is a critical record of its formation and evolution. Coupled to the mapping information, it provides unique clues to describe the history of the parent body. In particular, the capability to identify hydrated grains and to characterize their adjacent phases has a huge potential in the search for potential bio-relics in Martian samples. This purely non destructive characterization enables further analyses (e.g. through mass spectrometry) to be performed, and/or to contribute to sample selection to return to Earth. MicrOmega IR is coupled to a visible microscope: MicrOmega VIS. Thus, the MicrOmega instrument is developed by an international consortium: IAS (Orsay, France), LESIA (Meudon, France), CBM (Orléans, France), University Of Bern (Bern, Switzerland), IKI (Moscow, Russia). This instrument (MicrOmega IR, MicrOmega VIS and the electronics) is selected for the ESA Exomars mission (launch scheduled for 2013). MicrOmega IR will be used in a reduced spectral range (0.9 - 2.6 μm), due to power, mass and thermal constraints: however, most minerals and other constituents have diagnostic spectral signature in this range. A full demonstrator model of ExoMars/MicrOmega IR has been assembled at IAS and we will present the design and the experimental results.

Method and apparatus for fast laser-pulse detection using gaseous plasmas

DOEpatents

McLellan, E.J.; Webb, J.A.

1981-06-18

The method and device of the instant invention is a detector of pulsed laser radiation which utilizes the electromotive force generated by the plasma formed when such radiation is focused onto a surface. Measurements are made with a 10.6 ..mu..m CO/sub 2/ laser capable of producing peak intensities of 10/sup 13/ W/cm/sup 2/ when directed through a converging lens. Evacuated detector response to such laser intensity if 1 kV signal peak amplitude and subnanosecond risetimes into a 50 ..cap omega.. load. Detector performance is found to be greatly altered with the introduction of a background gas. For example, with one atmosphere of air, the detector produces prompt signals of the order of 1 V with subnanosecond response for pulse trains lasting 100 ns. With argon, krypton, or zenon at pressures of the order of 10 torr, the detector generates trigger pulses of about 250 V amplitude and 0.2 ns risetimes. Such detectors are quite robust when irradiated with high intensity laser radiation and are useful for qualitative laser beam monitoring.

QM2017: Status and Key open Questions in Ultra-Relativistic Heavy-Ion Physics

NASA Astrophysics Data System (ADS)

Schukraft, Jurgen

2017-11-01

Almost exactly 3 decades ago, in the fall of 1986, the era of experimental ultra-relativistic E / m ≫ 1) heavy ion physics started simultaneously at the SPS at CERN and the AGS at Brookhaven with first beams of light Oxygen ions at fixed target energies of 200 GeV/A and 14.6 GeV/A, respectively. The event was announced by CERN [CERN's subatomic particle accelerators: Set up world-record in energy and break new ground for physics (CERN-PR-86-11-EN) (1986) 4 p, issued on 29 September 1986. URL (http://cds.cern.ch/record/855571)

Update on CERN Search based on SharePoint 2013

NASA Astrophysics Data System (ADS)

Alvarez, E.; Fernandez, S.; Lossent, A.; Posada, I.; Silva, B.; Wagner, A.

2017-10-01

CERN’s enterprise Search solution “CERN Search” provides a central search solution for users and CERN service providers. A total of about 20 million public and protected documents from a wide range of document collections is indexed, including Indico, TWiki, Drupal, SharePoint, JACOW, E-group archives, EDMS, and CERN Web pages. In spring 2015, CERN Search was migrated to a new infrastructure based on SharePoint 2013. In the context of this upgrade, the document pre-processing and indexing process was redesigned and generalised. The new data feeding framework allows to profit from new functionality and it facilitates the long term maintenance of the system.

[The effect of diet ratio of polyunsaturated fatty acids of omega-3 and omega-6 families on activity of aminotransferases and gamma-glutamyltransferase in rat blood serum].

PubMed

Ketsa, O V; Marchenko, M M

2014-01-01

The effect of diet fat compositions with various ratio of omega-3 and omega-6 polyunsaturated fatty acids (PUFAs) on alanine aminotransferase (ALT), aspartate aminotransferase (AST) and gamma-glutamyltransferase (GGT) activities in blood serum of 45 white mongrel rats weighing 90-110 g (9 animals in group) has been investigated. Fat components in the semi-synthetic diet, compiled on the basis of AIN-93 diet, and sources of omega-6 and omega-3 PUFA were presented by sunflower oil, soybean oil and fish oil. It has been shown that four-week inclusion of linoleic acid (LA) and alpha-linolenic acid (alpha-LNA) in a ratio of 7:1 into the diet (soybean oil) as well as use of only omega-6 PUFA (sunflower oil) has lead to an increase in the activity of ALT and GGT in rat blood serum compared to control animals treated with the complex of linolenic, eicosapentaenoic (EPA) and docosahexaenoic (DHA) acid through the mixture of sunflower oil and fish oil (9:1) with the ratio of omega-6 and omega-3 PUFA 7:1. Along with this, the AST:ALT ratio (de Ritis ratio) was lower (p < 0.05) as compared with the control group of rat, amounting respectively 0.92 +/- 0.08 and 0.79 +/- 0.12 vs 1.26 +/- 0.10. The use of high doses of omega-3 fatty acids (600 mg EPA and 400 mg DHA per kg of animal weight per day coming through fish oil) did not affect the activity of ALT and GGT, but increased AST serum activity (0.47 +/- 0.04 micromoles/min per mg protein) and the de Ritis ratio (2.53 +/- 0.23). The diet deprived with fat increased enzyme activity of ALT, AST and GGT in rat blood serum.

Omega-3 polyunsaturated fatty acid has an anti-oxidant effect via the Nrf-2/HO-1 pathway in 3T3-L1 adipocytes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kusunoki, Chisato, E-mail: yosizaki@belle.shiga-med.ac.jp; Yang, Liu; Yoshizaki, Takeshi

Highlights: Black-Right-Pointing-Pointer Omega-3 PUFA has a direct anti-oxidant effect in adipocytes. Black-Right-Pointing-Pointer EPA and DHA induce HO-1 expression in 3T3-L1 adipocytes. Black-Right-Pointing-Pointer Omega-3 PUFA and its end-product, 4-HHE, activates the Nrf-2/HO-1 pathway. Black-Right-Pointing-Pointer Omega-3 PUFA protects against oxidative stress-induced cytotoxicity. -- Abstract: Oxidative stress is produced in adipose tissue of obese subjects and has been associated with obesity-related disorders. Recent studies have shown that omega-3 polyunsaturated fatty acid ({omega}3-PUFA) has beneficial effects in preventing atherosclerotic diseases and insulin resistance in adipose tissue. However, the role of {omega}3-PUFA on adipocytes has not been elucidated. In this study, 3T3-L1 adipocytes were treatedmore » with {omega}3-PUFA and its metabolites, eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), or 4-hydroxy hexenal (4-HHE). {omega}3-PUFA and its metabolites dose-dependently increased mRNA and protein levels of the anti-oxidative enzyme, heme oxygenase-1 (HO-1); whereas no changes in the well-known anti-oxidant molecules, superoxide dismutase, catalase, and glutathione peroxidase, were observed. Knockdown of nuclear factor erythroid 2-related factor 2 (Nrf-2) significantly reduced EPA, DHA or 4-HHE-induced HO-1 mRNA and protein expression. Also, pretreatment with {omega}3-PUFA prevented H{sub 2}O{sub 2}-induced cytotoxicity in a HO-1 dependent manner. In conclusion, treatment with EPA and DHA induced HO-1 through the activation of Nrf-2 and prevented oxidative stress in 3T3-L1 adipocytes. This anti-oxidant defense may be of high therapeutic value for clinical conditions associated with systemic oxidative stress.« less

Influence of omega-6/omega-3 rich dietary oils on lipid profile and antioxidant enzymes in normal and stressed rats.

PubMed

Benson, M K; Devi, Kshama

2009-02-01

To evaluate the influence of omega-6/omega-3 poly unsaturated fatty acid (PUFA) containing oils on lipid profile and endogenous antioxidant enzymes in normal and stressed (immobilization) rats, 28 day old male Wistar rats were fed for 45 days with fat enriched special diet (10% fat) prepared with sunflower oil (SO)--omega-6 rich, mustard oil (MO)--omega-3 rich and groundnut oil--control respectively. SO treated normal rats have significantly reduced total cholesterol, high density lipoprotein-cholesterol (HDL-C) and catalase thereby significantly increased the atherogenic index (AI) and lipid peroxidation (LPO). However, treatment with MO increased superoxide dismutase; decreased LPO significantly. Under stress conditions AI and LPO were significantly high with SO and significantly less with MO. In addition, SO decreased HDL-C whereas MO decreased non-HDL-C significantly. Results suggest a protective role against AI and LPO in normal and stress conditions in MO. The quantity of omega-3 fatty acids in dietary oil may play a crucial role in the body against atherogenicity. The findings signify that not just PUFA, but type of PUFA present in dietary oil used is important.

Omega-3 fatty acids prevent early-life antibiotic exposure-induced gut microbiota dysbiosis and later-life obesity.

PubMed

Kaliannan, K; Wang, B; Li, X-Y; Bhan, A K; Kang, J X

2016-06-01

Early-life antibiotic exposure can disrupt the founding intestinal microbial community and lead to obesity later in life. Recent studies show that omega-3 fatty acids can reduce body weight gain and chronic inflammation through modulation of the gut microbiota. We hypothesize that increased tissue levels of omega-3 fatty acids may prevent antibiotic-induced alteration of gut microbiota and obesity later in life. Here, we utilize the fat-1 transgenic mouse model, which can endogenously produce omega-3 fatty acids and thereby eliminates confounding factors of diet, to show that elevated tissue levels of omega-3 fatty acids significantly reduce body weight gain and the severity of insulin resistance, fatty liver and dyslipidemia resulting from early-life exposure to azithromycin. These effects were associated with a reversal of antibiotic-induced dysbiosis of gut microbiota in fat-1 mice. These results demonstrate the beneficial effects of omega-3 fatty acids on antibiotic-induced gut dysbiosis and obesity, and suggest the potential utility of omega-3 supplementation as a safe and effective means for the prevention of obesity in children who are exposed to antibiotics.

40 CFR 721.10690 - Benzenedicarboxylic acid, polymer with substituted alkanediol, dodecanedioic acid, 1,2-ethanediol...

Code of Federal Regulations, 2014 CFR

2014-07-01

..., alkanediol,.alpha.-hydro-.omega.-hydroxypoly[oxyalkanediyl], 1,3-isobenzofurandione, methylene diphenyl...-ethanediol, alkanedioic acid, alkanediol,.alpha.-hydro-.omega.-hydroxypoly[oxyalkanediyl], 1,3... substituted alkanediol, dodecanedioic acid, 1,2-ethanediol, alkanedioic acid, alkanediol,.alpha.-hydro-.omega...

Targeted Alteration of Dietary Omega 3 and Omega 6 Fatty Acids for the Treatment of Post Traumatic Headaches

DTIC Science & Technology

2017-10-01

AWARD NUMBER: W81XWH-15-2-0059 TITLE: Targeted Alteration of Dietary Omega-3 and Omega-6 Fatty Acids for the Treatment of Post -Traumatic...Acids for the Treatment of Post - 5b. GRANT NUMBER Traumatic Headaches 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER Kimbra Kenney, M.D...SUPPLEMENTARY NOTES 14. ABSTRACT Post -traumatic headache (PTH) is a common problem in military personnel due to their high rate of traumatic brain

Low cost omega navigation receiver

NASA Technical Reports Server (NTRS)

Lilley, R. W.

1974-01-01

The development of a low cost Omega navigation receiver is discussed. Emphasis is placed on the completion and testing of a modular, multipurpose Omega receiver which utilizes a digital memory-aided, phase-locked loop to provide phase measurement data to a variety of applications interfaces. The functional units contained in the prototype device are described. The receiver is capable of receiving and storing phase measurements for up to eight Omega signals and computes two switch-selectable lines of position, displaying this navigation data in chart-recorded form.

Harmonic mixing characteristics of metal-barrier-metal junctions as predicted by electron tunneling

NASA Technical Reports Server (NTRS)

Faris, S. M.; Gustafson, T. K.

1974-01-01

The bias dependence of the nonlinear mixing characteristics of metal-barrier-metal junction currents is deduced assuming an electron tunneling model. The difference-frequency beat voltage at frequency omega sub 1 - (n x omega sub 2), when n is an integer and omega sub 1 and omega sub 2 are the assumed frequencies of two induced currents, is found to have n zeros as the diode bias is varied. Recent experimental observations have demonstrated such characteristics.

AdS black disk model for small-x DIS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cornalba, Lorenzo; Costa, Miguel S.; Penedones, Joao

2011-05-23

Using the approximate conformal invariance of QCD at high energies we consider a simple AdS black disk model to describe saturation in DIS. Deep inside saturation the structure functions have the same power law scaling, F{sub T}{approx}F{sub L}{approx}{sup -}{omega}, where {omega} is related to the expansion rate of the black disk with energy. Furthermore, the ratio F{sub L}/F{sub T} is given by the universal value (1+{omega}/3+{omega}), independently of the target.

Nonlinear response of a harmonic diatomic molecule: Algebraic nonperturbative calculation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Recamier, Jose; Mochan, W. Luis; Maytorena, Jesus A.

2005-08-15

Even harmonic molecules display a nonlinear behavior when driven by an inhomogeneous field. We calculate the response of single harmonic molecules to a monochromatic time and space dependent electric field E(r,t) of frequency {omega} employing exact algebraic methods. We evaluate the responses at the fundamental frequency {omega} and at successive harmonics 2{omega}, 3{omega}, etc., as a function of the intensity and of the frequency of the field and compare the results with those of first and second order perturbation theory.

40 CFR 721.10160 - Poly(oxy-1,2-ethanediyl), .alpha.-[(13Z)-1-oxo-13-docosen-1-yl]-.omega.-[[(13Z)-1-oxo-13-docosen...

Code of Federal Regulations, 2012 CFR

2012-07-01

....-[(13Z)-1-oxo-13-docosen-1-yl]-.omega.-[[(13Z)-1-oxo-13-docosen-1-yl]oxy]-. 721.10160 Section 721.10160... Poly(oxy-1,2-ethanediyl), .alpha.-[(13Z)-1-oxo-13-docosen-1-yl]-.omega.-[[(13Z)-1-oxo-13-docosen-1-yl... substance identified as poly(oxy-1,2-ethanediyl), .alpha.-[(13Z)-1-oxo-13-docosen-1-yl]-.omega.-[[(13Z)-1...

40 CFR 721.10160 - Poly(oxy-1,2-ethanediyl), .alpha.-[(13Z)-1-oxo-13-docosen-1-yl]-.omega.-[[(13Z)-1-oxo-13-docosen...

Code of Federal Regulations, 2010 CFR

2010-07-01

....-[(13Z)-1-oxo-13-docosen-1-yl]-.omega.-[[(13Z)-1-oxo-13-docosen-1-yl]oxy]-. 721.10160 Section 721.10160... Poly(oxy-1,2-ethanediyl), .alpha.-[(13Z)-1-oxo-13-docosen-1-yl]-.omega.-[[(13Z)-1-oxo-13-docosen-1-yl... substance identified as poly(oxy-1,2-ethanediyl), .alpha.-[(13Z)-1-oxo-13-docosen-1-yl]-.omega.-[[(13Z)-1...

40 CFR 721.10160 - Poly(oxy-1,2-ethanediyl), .alpha.-[(13Z)-1-oxo-13-docosen-1-yl]-.omega.-[[(13Z)-1-oxo-13-docosen...

Code of Federal Regulations, 2014 CFR

2014-07-01

....-[(13Z)-1-oxo-13-docosen-1-yl]-.omega.-[[(13Z)-1-oxo-13-docosen-1-yl]oxy]-. 721.10160 Section 721.10160... Poly(oxy-1,2-ethanediyl), .alpha.-[(13Z)-1-oxo-13-docosen-1-yl]-.omega.-[[(13Z)-1-oxo-13-docosen-1-yl... substance identified as poly(oxy-1,2-ethanediyl), .alpha.-[(13Z)-1-oxo-13-docosen-1-yl]-.omega.-[[(13Z)-1...

40 CFR 721.10160 - Poly(oxy-1,2-ethanediyl), .alpha.-[(13Z)-1-oxo-13-docosen-1-yl]-.omega.-[[(13Z)-1-oxo-13-docosen...

Code of Federal Regulations, 2013 CFR

2013-07-01

....-[(13Z)-1-oxo-13-docosen-1-yl]-.omega.-[[(13Z)-1-oxo-13-docosen-1-yl]oxy]-. 721.10160 Section 721.10160... Poly(oxy-1,2-ethanediyl), .alpha.-[(13Z)-1-oxo-13-docosen-1-yl]-.omega.-[[(13Z)-1-oxo-13-docosen-1-yl... substance identified as poly(oxy-1,2-ethanediyl), .alpha.-[(13Z)-1-oxo-13-docosen-1-yl]-.omega.-[[(13Z)-1...

40 CFR 721.10160 - Poly(oxy-1,2-ethanediyl), .alpha.-[(13Z)-1-oxo-13-docosen-1-yl]-.omega.-[[(13Z)-1-oxo-13-docosen...

Code of Federal Regulations, 2011 CFR

2011-07-01

....-[(13Z)-1-oxo-13-docosen-1-yl]-.omega.-[[(13Z)-1-oxo-13-docosen-1-yl]oxy]-. 721.10160 Section 721.10160... Poly(oxy-1,2-ethanediyl), .alpha.-[(13Z)-1-oxo-13-docosen-1-yl]-.omega.-[[(13Z)-1-oxo-13-docosen-1-yl... substance identified as poly(oxy-1,2-ethanediyl), .alpha.-[(13Z)-1-oxo-13-docosen-1-yl]-.omega.-[[(13Z)-1...

Omega-3 Fatty Acid Formulations in Cardiovascular Disease: Dietary Supplements are Not Substitutes for Prescription Products.

PubMed

Fialkow, Jonathan

2016-08-01

Omega-3 fatty acid products are available as prescription formulations (icosapent ethyl, omega-3-acid ethyl esters, omega-3-acid ethyl esters A, omega-3-carboxylic acids) and dietary supplements (predominantly fish oils). Most dietary supplements and all but one prescription formulation contain mixtures of the omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). Products containing both EPA and DHA may raise low-density lipoprotein cholesterol (LDL-C). In clinical trials, the EPA-only prescription product, icosapent ethyl, did not raise LDL-C compared with placebo. To correct a common misconception, it is important to note that omega-3 fatty acid dietary supplements are not US FDA-approved over-the-counter drugs and are not required to demonstrate safety and efficacy prior to marketing. Conversely, prescription products are supported by extensive clinical safety and efficacy investigations required for FDA approval and have active and ongoing safety monitoring programs. While omega-3 fatty acid dietary supplements may have a place in the supplementation of diet, they generally contain lower levels of EPA and DHA than prescription products and are not approved or intended to treat disease. Perhaps due to the lack of regulation of dietary supplements, EPA and DHA levels may vary widely within and between brands, and products may also contain unwanted cholesterol or fats or potentially harmful components, including toxins and oxidized fatty acids. Accordingly, omega-3 fatty acid dietary supplements should not be substituted for prescription products. Similarly, prescription products containing DHA and EPA should not be substituted for the EPA-only prescription product, as DHA may raise LDL-C and thereby complicate the management of patients with dyslipidemia.

Intake of total omega-3 fatty acids, eicosapentaenoic acid and docosahexaenoic acid and risk of coronary heart disease in the Spanish EPIC cohort study.

PubMed

Amiano, P; Machón, M; Dorronsoro, M; Chirlaque, M Dolores; Barricarte, A; Sánchez, M-J; Navarro, C; Huerta, J M; Molina-Montes, E; Sánchez-Cantalejo, E; Urtizberea, M; Arriola, L; Larrañaga, N; Ardanaz, E; Quirós, J R; Moreno-Iribas, C; González, C A

2014-03-01

The evidence about the benefits of omega-3 fatty acid intake on coronary heart disease (CHD) is not consistent. We thus aimed to assess the relation between dietary intake of total omega-3 fatty acids (from plant and marine foods) and marine polyunsaturated fatty acids (PUFAs), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), on the risk of CHD in the Spanish cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC). The analysis included 41,091 men and women aged 20-69 years, recruited from 1992 to 1996 and followed-up until December 2004. Omega-3 fatty acid intake was estimated from a validated dietary questionnaire. Only participants with definite incident CHD event were considered as cases. Cox regression models were used to assess the association between the intake of total omega-3 fatty acids, EPA or DHA and CHD. A total of 609 participants (79% men) had a definite CHD event. Mean intakes of total omega-3 fatty acids, EPA and DHA were very similar in the cases and in the cohort, both in men and women. In the multivariate adjusted model, omega-3 fatty acids, EPA and DHA were not related to incident CHD in either men or women. The hazard ratios (HR) for omega-3 were 1.23 in men (95% CI 0.94-15.9, p = 0.20); and 0.77 in women (95% CI 0.46-1.30, p = 0.76). In the Spanish EPIC cohort, with a relatively high intake of fish, no association was found between EPA, DHA and total omega-3 fatty acid intake and risk of CHD. Copyright © 2013 Elsevier B.V. All rights reserved.

Potentiation of omega-3 fatty acid antidepressant-like effects with low non-antidepressant doses of fluoxetine and mirtazapine.

PubMed

Laino, Carlos Horacio; Fonseca, Cristina; Sterin-Speziale, Norma; Slobodianik, Nora; Reinés, Analía

2010-12-01

Despite the advances in psychopharmacology, the treatment of depressive disorders is still not satisfactory. Side effects and resistance to antidepressant drugs are the greatest complications during treatment. Based on recent evidence, omega-3 fatty acids may influence vulnerability and outcome in depressive disorders. The aim of this study was to further characterize the omega-3 antidepressant-like effect in rats in terms of its behavioral features in the depression model forced swimming test either alone or in combination with antidepressants fluoxetine or mirtazapine. Ultimately, we prompted to determine the lowest dose at which omega-3 fatty acids and antidepressant drugs may still represent a pharmacological advantage when employed in combined treatments. Chronic diet supplementation with omega-3 fatty acids produced concentration-dependent antidepressant-like effects in the forced swimming test displaying a behavioral profile similar to fluoxetine but different from mirtazapine. Fluoxetine or mirtazapine at antidepressant doses (10 and 20 mg/kg/day, respectively) rendered additive effects in combination with omega-3 fatty acid supplementation (720 mg/kg/day). Beneficial effects of combined treatment were also observed at sub-effective doses (1 mg/kg/day) of fluoxetine or mirtazapine, since in combination with omega-3 fatty acids (720 mg/kg/day), antidepressants potentiated omega-3 antidepressant-like effects. The antidepressant-like effects occurred in the absence of changes in brain phospholipid classes. The therapeutic approach of combining omega-3 fatty acids with low ineffective doses of antidepressants might represent benefits in the treatment of depression, especially in patients with depression resistant to conventional treatments and even may contribute to patient compliance by decreasing the magnitude of some antidepressant dose-dependent side effects. Copyright © 2010 Elsevier B.V. All rights reserved.

Omega 3 (peripheral type benzodiazepine binding) site distribution in the rat immune system: an autoradiographic study with the photoaffinity ligand (/sup 3/H)PK 14105

DOE Office of Scientific and Technical Information (OSTI.GOV)

Benavides, J.; Dubois, A.; Dennis, T.

1989-04-01

The anatomical distribution of omega 3 (peripheral type benzodiazepine binding) sites in the immune system organs of the rat has been studied autoradiographically at both macroscopic and microscopic levels of resolution using either reversible or irreversible (UV irradiation) labeling with (/sup 3/H)PK 14105. In thymus sections, (/sup 3/H)PK 14105 labeled with high affinity (Kd, derived from saturation experiments = 10.8 nM) a single population of sites which possessed the pharmacological characteristics of omega 3 sites. In the thymus gland, higher omega 3 site densities were detected in the cortex than in the medulla; in these subregions, silver grains were associatedmore » to small (10-18 microns diameter) cells. In the spleen, omega 3 sites were more abundant in the white than in the red pulp. In the white pulp, silver grains were denser in the marginal zone than in the vicinity of the central artery and labeling was, as in the thymus, associated to small cytoplasm-poor cells. In the red pulp, omega 3 site associated silver grains were observed mainly in the Bilroth cords. In the lymph nodes, the medullary region showed a higher labeling than the surrounding follicles and paracortex. A significant accumulation of silver grains was observed in the lymph node medullary cords. In the intestine, Peyer patches were particularly enriched in omega 3 sites (especially in the periphery of the follicles). The distribution of omega 3 sites in the immune system organs suggests a preferential labeling of cells of T and monocytic lineages. This is consistent with the proposed immunoregulatory properties of some omega 3 site ligands.« less

Oral Omega-3 Supplementation Lowers Intraocular Pressure in Normotensive Adults.

PubMed

Downie, Laura Elizabeth; Vingrys, Algis Jonas

2018-05-01

Elevated intraocular pressure (IOP) is the major modifiable risk factor for the sight-threatening eye disease, glaucoma. We investigated whether oral omega-3 supplements affect IOP in normotensive adults. We undertook a pooled analysis of data from two double-masked, placebo-controlled randomized trials (Australian New Zealand Clinical Trials Registry, ACTRN12614001019695, ACTRN12615000173594) that investigated the efficacy and safety of oral omega-3 supplementation for treating ocular surface inflammation. Recruitment involved adults ( n = 105) with IOP <21 mm Hg, and without a current or prior glaucoma diagnosis. Participants were randomly allocated to either an oral omega-3 (∼1000 mg/day eicosapentaenoic acid + ∼500 mg/day docosahexaenoic acid ± 900 mg/day α-linolenic acid) or placebo (olive oil, 1500 mg/day) supplement. IOP was quantified at baseline and after 3 months of supplementation (day 90). Change in IOP, relative to baseline, was compared between groups. At baseline, participants were of similar age (omega-3/placebo groups: mean ± SEM, 33.7 ± 1.7, n = 72/35.6 ± 3.0 years, n = 33), sex (65%/79% female), and had similar IOP (14.3 ± 0.3/13.8 ± 0.5 mm Hg). At day 90, IOP was reduced to 13.6 ± 0.3 mm Hg in the omega-3 group; controls had a slight IOP increase to 14.2 ± 0.4 mm Hg ( P < 0.05). Oral omega-3 supplementation for 3 months significantly reduced IOP in normotensive adults. To our knowledge, this is the first study to report that omega-3 fatty acids lower IOP in humans. These findings justify further investigation into the therapeutic potential of omega-3 supplementation for reducing IOP, to prevent and/or treat conditions with IOP elevation, including ocular hypertension and glaucoma.

Supplementation with Omega-3 Fatty Acids in Psychiatric Disorders: A Review of Literature Data

PubMed Central

Bozzatello, Paola; Brignolo, Elena; De Grandi, Elisa; Bellino, Silvio

2016-01-01

A new application for omega-3 fatty acids has recently emerged, concerning the treatment of several mental disorders. This indication is supported by data of neurobiological research, as highly unsaturated fatty acids (HUFAs) are highly concentrated in neural phospholipids and are important components of the neuronal cell membrane. They modulate the mechanisms of brain cell signaling, including the dopaminergic and serotonergic pathways. The aim of this review is to provide a complete and updated account of the empirical evidence of the efficacy and safety that are currently available for omega-3 fatty acids in the treatment of psychiatric disorders. The main evidence for the effectiveness of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) has been obtained in mood disorders, in particular in the treatment of depressive symptoms in unipolar and bipolar depression. There is some evidence to support the use of omega-3 fatty acids in the treatment of conditions characterized by a high level of impulsivity and aggression and borderline personality disorders. In patients with attention deficit hyperactivity disorder, small-to-modest effects of omega-3 HUFAs have been found. The most promising results have been reported by studies using high doses of EPA or the association of omega-3 and omega-6 fatty acids. In schizophrenia, current data are not conclusive and do not allow us either to refuse or support the indication of omega-3 fatty acids. For the remaining psychiatric disturbances, including autism spectrum disorders, anxiety disorders, obsessive-compulsive disorder, eating disorders and substance use disorder, the data are too scarce to draw any conclusion. Concerning tolerability, several studies concluded that omega-3 can be considered safe and well tolerated at doses up to 5 g/day. PMID:27472373

Effect of dietary selenium and omega-3 fatty acids on muscle composition and quality in broilers

PubMed Central

Haug, Anna; Eich-Greatorex, Susanne; Bernhoft, Aksel; Wold, Jens P; Hetland, Harald; Christophersen, Olav A; Sogn, Trine

2007-01-01

Background Human health may be improved if dietary intakes of selenium and omega-3 fatty acids are increased. Consumption of broiler meat is increasing, and the meat content of selenium and omega-3 fatty acids are affected by the composition of broiler feed. A two-way analyses of variance was used to study the effect of feed containing omega-3 rich plant oils and selenium enriched yeast on broiler meat composition, antioxidation- and sensory parameters. Four different wheat-based dietary treatments supplemented with 5% rapeseed oil or 4% rapeseed oil plus 1% linseed oil, and either 0.50 mg selenium or 0.84 mg selenium (organic form) per kg diet was fed to newly hatched broilers for 22 days. Results The different dietary treatments gave distinct different concentrations of selenium and fatty acids in thigh muscle; one percent linseed oil in the diet increased the concentration of the omega-3 fatty acids 18:3, 20:5 and 22:5, and 0.84 mg selenium per kg diet gave muscle selenium concentration at the same level as is in fish muscle (0.39 mg/kg muscle). The high selenium intake also resulted in increased concentration of the long-chain omega-3 fatty acids EPA (20:5), DPA (22:5) and DHA (22:6), thus it may be speculated if high dietary selenium might have a role in increasing the concentration of EPA, DPA and DHA in tissues after intake of plant oils contning omega-3 fatty acids. Conclusion Moderate modifications of broiler feed may give a healthier broiler meat, having increased content of selenium and omega-3 fatty acids. High intakes of selenium (organic form) may increase the concentration of very long-chain omega-3 fatty acids in muscle. PMID:17967172

Matrix metalloproteinase (MMP)-9 in cancer-associated fibroblasts (CAFs) is suppressed by omega-3 polyunsaturated fatty acids in vitro and in vivo.

PubMed

Taguchi, Ayumi; Kawana, Kei; Tomio, Kensuke; Yamashita, Aki; Isobe, Yosuke; Nagasaka, Kazunori; Koga, Kaori; Inoue, Tomoko; Nishida, Haruka; Kojima, Satoko; Adachi, Katsuyuki; Matsumoto, Yoko; Arimoto, Takahide; Wada-Hiraike, Osamu; Oda, Katsutoshi; Kang, Jing X; Arai, Hiroyuki; Arita, Makoto; Osuga, Yutaka; Fujii, Tomoyuki

2014-01-01

Cancer associated fibroblasts (CAFs) are responsible for tumor growth, angiogenesis, invasion, and metastasis. Matrix metalloproteinase (MMP)-9 secreted from cancer stroma populated by CAFs is a prerequisite for cancer angiogenesis and metastasis. Omega-3 polyunsaturated fatty acids (omega-3 PUFA) have been reported to have anti-tumor effects on diverse types of malignancies. Fat-1 mice, which can convert omega-6 to omega-3 PUFA independent of diet, are useful to investigate the functions of endogenous omega-3 PUFA. To examine the effect of omega-3 PUFA on tumorigenesis, TC-1 cells, a murine epithelial cell line immortalized by human papillomavirus (HPV) oncogenes, were injected subcutaneously into fat-1 or wild type mice. Tumor growth and angiogenesis of the TC-1 tumor were significantly suppressed in fat-1 compared to wild type mice. cDNA microarray of the tumors derived from fat-1 and wild type mice revealed that MMP-9 is downregulated in fat-1 mice. Immunohistochemical study demonstrated immunoreactivity for MMP-9 in the tumor stromal fibroblasts was diffusely positive in wild type whereas focal in fat-1 mice. MMP-9 was expressed in primary cultured fibroblasts isolated from fat-1 and wild type mice but was not expressed in TC-1 cells. Co-culture of fibroblasts with TC-1 cells enhanced the expression and the proteinase activity of MMP-9, although the protease activity of MMP-9 in fat-1-derived fibroblasts was lower than that in wild type fibroblasts. Our data suggests that omega-3 PUFAs suppress MMP-9 induction and tumor angiogenesis. These findings may provide insight into mechanisms by which omega-3 PUFAs exert anti-tumor effects by modulating tumor microenvironment.

Big Bang Day: The Making of CERN (Episode 1)

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

2009-10-06

A two-part history of the CERN project. Quentin Cooper explores the fifty-year history of CERN, the European particle physics laboratory in Switzerland. The institution was created to bring scientists together after WW2 .......

Big Bang Day: The Making of CERN (Episode 1)

ScienceCinema

None

2017-12-09

A two-part history of the CERN project. Quentin Cooper explores the fifty-year history of CERN, the European particle physics laboratory in Switzerland. The institution was created to bring scientists together after WW2 .......

Differences in Pop Levels between Conventional and Omega-3 Fatty Acid-Enriched Milk and Dairy Products

PubMed Central

Guerranti, Cristiana; Focardi, Silvano Ettore

2011-01-01

Conventional and omega-3 fatty acid-enriched milk and cheese were analyzed for persistent organic pollutants (POPs). Omega-3-enriched products are usually supplemented with fish oil which is potentially contaminated. All classes of the considered POPs (PCBs, DDT, HCB, PBDEs, and PCDD/Fs) were found in the samples, with average concentrations higher in omega-3-enriched products than in conventional ones. For PCBs, DDT, and HCB, differences were statistically significant and, therefore, cannot be ascribed to normal variability. With regard to all classes of compounds, the highest levels in individual samples were always found in omega-3 products, in line with the hypothesis that these foods are potentially more contaminated than conventional ones. PMID:23724286

Coherent control of ultrafast optical four-wave mixing with two-color {omega}-3{omega} laser pulses

DOE Office of Scientific and Technical Information (OSTI.GOV)

Serrat, Carles

2005-08-15

A theoretical investigation on the coherent control of optical transient four-wave mixing interactions in two-level systems with two intense few-cycle propagating laser pulses of central angular frequencies {omega} and 3{omega} is reported. By numerically solving the full Maxwell-Bloch equations beyond the slowly varying envelope and rotating-wave approximations in the time domain, the nonlinear coupling to the optical field at frequency 5{omega} is found to depend critically on the initial relative phase {phi} of the propagating pulses: the coupling is enhanced when the pulses interfere constructively in the center ({phi}=0), while it is nearly suppressed when they are out of phasemore » ({phi}={pi})« less

AdS Black Disk Model for Small-x Deep Inelastic Scattering

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cornalba, Lorenzo; Costa, Miguel S.; Penedones, Joao

2010-08-13

Using the approximate conformal invariance of QCD at high energies we consider a simple anti-de Sitter black disk model to describe saturation in deep inelastic scattering. Deep inside saturation the structure functions have the same power law scaling, F{sub T}{approx}F{sub L}{approx}x{sup -{omega}}, where {omega} is related to the expansion rate of the black disk with energy. Furthermore, the ratio F{sub L}/F{sub T} is given by the universal value (1+{omega}/3+{omega}), independently of the target. For {gamma}*-{gamma}* scattering at high energies we obtain explicit expressions and ratios for the total cross sections of transverse and longitudinal photons in terms of the singlemore » parameter {omega}.« less

77 FR 76029 - Certain New Chemicals; Receipt and Status Information

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-26

..., .alpha.- hydro-.omega.- hydroxypoly[oxy(methyl- 1,2-ethanediyl)], 1,3- isobenzofurandione, 1,1..., .alpha.- hydro-.omega.- hydroxypoly[oxy(methyl- 1,2-ethanediyl)], 1,3- isobenzofurandione, 1,1..., alkanediol, .alpha.- hydro-.omega.- hydroxypoly[oxy(methyl- 1,2-ethanediyl)], 1,3- isobenzofurandione, 1,1...

21 CFR 178.1010 - Sanitizing solutions.

Code of Federal Regulations, 2011 CFR

2011-04-01

...-nium chloride, sodium metaborate, alpha-terpineol and alpha[p-(1,1,3,3-tetramethylbutyl)phenyl] -omega...-(1,1,3,3-tetramethylbutyl)-phenyl]-omega-hydroxypoly-(oxyethylene) produced with one mole of the... parts per million of alpha[p-(1,1,3,3-tetramethylbutyl) phenyl]-omega-hydroxypoly (oxyethylene). (14...

21 CFR 178.1010 - Sanitizing solutions.

Code of Federal Regulations, 2013 CFR

2013-04-01

...-nium chloride, sodium metaborate, alpha-terpineol and alpha[p-(1,1,3,3-tetramethylbutyl)phenyl] -omega...-(1,1,3,3-tetramethylbutyl)-phenyl]-omega-hydroxypoly-(oxyethylene) produced with one mole of the... parts per million of alpha[p-(1,1,3,3-tetramethylbutyl) phenyl]-omega-hydroxypoly (oxyethylene). (14...

21 CFR 178.1010 - Sanitizing solutions.

Code of Federal Regulations, 2012 CFR

2012-04-01

...-nium chloride, sodium metaborate, alpha-terpineol and alpha[p-(1,1,3,3-tetramethylbutyl)phenyl] -omega...-(1,1,3,3-tetramethylbutyl)-phenyl]-omega-hydroxypoly-(oxyethylene) produced with one mole of the... parts per million of alpha[p-(1,1,3,3-tetramethylbutyl) phenyl]-omega-hydroxypoly (oxyethylene). (14...

Long-chain omega-3 from low-trophic-level fish provides value to farmed seafood

PubMed Central

Bibus, Douglas M

2015-01-01

Low-trophic-level fish are a crucial source of long-chain (LC) omega-3 fatty acids for farmed fish and humans. Many farm-raised fish species have a clear need for these nutrients. Farmed fish deposit the LC omega-3s in their flesh and transfer them up the food chain. However, the content of LC omega-3s in farm-raised seafood continues to decline, while the content of shorter-chain plant-sourced omega-3s, and pro-inflammtory omega-6s continue to increase. This reduces its nutritional worth. The value of low-trophic-level fish is often viewed merely as its price at the dock. Some reports and metrics steer public attention towards the mass balance between quantities of low-trophic-level fish and farmed seafood. However, the the nutritional value of seafood is more important than its mere quantities. The role of low-trophic-level fish in human nutrition, health, and wellbeing is a fundamental component of its economic value to society. PMID:26097289

Proper balance of omega-3 and omega-6 fatty acid supplements with topical cyclosporine attenuated contact lens-related dry eye syndrome.

PubMed

Wang, Ling; Chen, Xi; Hao, Jingfang; Yang, Lu

2016-12-01

Essential fatty acids had been applied in the treatment of dry eye syndrome (DES), but the effects of different combinations of fatty acids have not been investigated. 360 long-term contact lens wearers were included in this double-blinded study. Omega-3 and omega-6 fatty acids were combined in different ratios and supplied to the participants that were randomly divided into six groups, and the effects of different essential fatty acids mixture on DES with or without topical cyclosporine were investigated. More than half of long-term contact lens wearers suffered from DES, which were found to be attenuated by oral supplement of properly balanced O3FA and O6FA fatty acid. The topical cyclosporine treatment considerably inhibited the production of cytokines compared to the cyclosporine negative groups, which further relieved DES. Proper balance of omega-3 and omega-6 fatty acid combination significantly alleviated contact lens-related DES.

Long-chain omega-3 from low-trophic-level fish provides value to farmed seafood.

PubMed

Bibus, Douglas M

2015-03-01

Low-trophic-level fish are a crucial source of long-chain (LC) omega-3 fatty acids for farmed fish and humans. Many farm-raised fish species have a clear need for these nutrients. Farmed fish deposit the LC omega-3s in their flesh and transfer them up the food chain. However, the content of LC omega-3s in farm-raised seafood continues to decline, while the content of shorter-chain plant-sourced omega-3s, and pro-inflammtory omega-6s continue to increase. This reduces its nutritional worth. The value of low-trophic-level fish is often viewed merely as its price at the dock. Some reports and metrics steer public attention towards the mass balance between quantities of low-trophic-level fish and farmed seafood. However, the the nutritional value of seafood is more important than its mere quantities. The role of low-trophic-level fish in human nutrition, health, and wellbeing is a fundamental component of its economic value to society.

Theoretical analysis of high-order harmonic generation from a coherent superposition of states

DOE Office of Scientific and Technical Information (OSTI.GOV)

Milosevic, Dejan B.; Max-Born-Institut, Max-Born-Strasse 2a, Berlin, 12489

2006-02-15

A quantum theory of high-order harmonic generation by a strong laser field in the presence of more bound states is formulated. The obtained numerical and analytical results for a two-state hydrogenlike atom model show that the harmonic spectrum consists of two parts: a usual single-state harmonic spectrum of odd harmonics having the energies (2k+1){omega} and a resonant part with the peaks around the excitation energy {delta}{omega}. The energy of the harmonics in the resonant part of the spectrum is equal to {delta}{omega}{+-}{omega}, {delta}{omega}{+-}3{omega}, .... For energies higher than the excitation energy, the resonant part forms a plateau, followed by amore » cutoff. The emission rate of the harmonics in this resonant plateau is many orders of magnitude higher than that of the harmonics generated in the presence of the ground state alone. The influence of the depletion of the initial states, as well as of the pulse shape and intensity, is analyzed.« less

On Spectral Invariance of Single Scattering Albedo for Water Droplets and Ice Crystals at Weakly Absorbing Wavelengths

NASA Technical Reports Server (NTRS)

Marshak, Alexander; Knyazikhin, Yuri; Chiu, J. Christine; Wiscombe, Warren J.

2012-01-01

The single scattering albedo omega(sub O lambda) in atmospheric radiative transfer is the ratio of the scattering coefficient to the extinction coefficient. For cloud water droplets both the scattering and absorption coefficients, thus the single scattering albedo, are functions of wavelength lambda and droplet size r. This note shows that for water droplets at weakly absorbing wavelengths, the ratio omega(sub O lambda)(r)/omega(sub O lambda)(r (sub O)) of two single scattering albedo spectra is a linear function of omega(sub O lambda)(r). The slope and intercept of the linear function are wavelength independent and sum to unity. This relationship allows for a representation of any single scattering albedo spectrum omega(sub O lambda)(r) via one known spectrum omega(sub O lambda)(r (sub O)). We provide a simple physical explanation of the discovered relationship. Similar linear relationships were found for the single scattering albedo spectra of non-spherical ice crystals.

Encapsulation of vegetable oils as source of omega-3 fatty acids for enriched functional foods.

PubMed

Ruiz Ruiz, Jorge Carlos; Ortiz Vazquez, Elizabeth De La Luz; Segura Campos, Maira Rubi

2017-05-03

Polyunsaturated omega-3 fatty acids (PUFAs), a functional component present in vegetable oils, are generally recognized as being beneficial to health. Omega-3 PUFAs are rich in double bonds and unsaturated in nature; this attribute makes them highly susceptible to lipid oxidation and unfit for incorporation into long shelf life foods. The microencapsulation of oils in a polymeric matrix (mainly polysaccharides) offers the possibility of controlled release of the lipophilic functional ingredient and can be useful for the supplementation of foods with PUFAs. The present paper provides a literature review of different vegetable sources of omega-3 fatty acids, the functional effects of omega-3 fatty acids, different microencapsulation methods that can possibly be used for the encapsulation of oils, the properties of vegetable oil microcapsules, the effect of encapsulation on oxidation stability and fatty acid composition of vegetable oils, and the incorporation of long-chain omega-3 polyunsaturated fatty acids in foods.

CERN welcomes new members

NASA Astrophysics Data System (ADS)

2017-08-01

Lithuania is on course to become an associate member of CERN, pending final approval by the Lithuanian parliament. Associate membership will allow representatives of the Baltic nation to take part in meetings of the CERN Council, which oversees the Geneva-based physics lab.

Role of ionization and electron drift velocity profile to Rayleigh instability in a Hall thruster plasma

DOE Office of Scientific and Technical Information (OSTI.GOV)

Singh, Sukhmander; Malik, Hitendra K.

Role of ionization to Rayleigh instability is clarified in a Hall thruster plasma under the variety of profiles of electron drift velocity, namely, step-like profile (SLP) and two different super-Gaussian profiles (SGP1 and SGP2). For this, a relevant Rayleigh equation is derived and solved numerically using fourth-order Runge-Kutta method. Interestingly, an upper cutoff frequency of oscillations {omega}{sub max} is realized for the occurrence of the instability that shows dependence on the ionization rate {alpha}, electron drift velocity u{sub 0}, electron cyclotron frequency {Omega}, azimuthal wave number k{sub y}, plasma density n{sub 0}, density gradient {partial_derivative}n{sub 0}/{partial_derivative}x, ion (electron) thermal speedmore » V{sub thI}(V{sub thE}), and ion (electron) plasma frequency {omega}{sub pi}({omega}{sub pe}). The frequency {omega}{sub max} follows the trend {omega}{sub max} (for SGP2) >{omega}{sub max} (for SLP) >{omega}{sub max} (for SGP1) and shows a similar behaviour with ionization for all types of the velocity profiles. The instability is found to grow faster for the higher {alpha} and the ion temperature but it acquires lower rate under the effect of the higher electron temperature; the perturbed potential also varies in accordance with the growth rate. The electron temperature influences the growth rate and cutoff frequency less significantly in comparison with the ion temperature.« less

Probiotics Supplemented with Omega-3 Fatty Acids are More Effective for Hepatic Steatosis Reduction in an Animal Model of Obesity.

PubMed

Kobyliak, Nazarii; Falalyeyeva, Tetyana; Bodnar, Petro; Beregova, Tetyana

2017-06-01

Today probiotics have been suggested as a treatment for the prevention of NAFLD. Omega-3 fatty acid supplementation may have beneficial effects in regulating hepatic lipid metabolism, adipose tissue function and inflammation. The present study was designed to determine whether probiotics plus omega-3 are superior to probiotics alone on the monosodium glutamate (MSG)-induced NAFLD model in rats. We included 60 rats divided into four groups, 15 animals in each. Rats of group I were intact. Newborn rats of groups II-IV were injected with MSG. The III (Symbiter) group received 2.5 ml/kg of multiprobiotic "Symbiter" containing concentrated biomass of 14 probiotic bacteria genera. The IV (Symbiter-Omega) groups received "Symbiter-Omega" combination of probiotic biomass supplemented with flax and wheat germ oil (250 mg of each, concentration of omega-3 fatty acids 1-5 %). In both interventional groups reduction in total NAS score was observed. Supplementation of alive probiotic mixture with omega-3 fatty acids lead to 20 % higher decrease in steatosis score (0.73 ± 0.11 vs 0.93 ± 0.22, p = 0.848) and reduction by 16.6 % of triglycerides content in liver as compared to probiotic alone. Our study demonstrated more pronounced reduction in hepatic steatosis and hepatic lipid accumulation after treatment with combination of alive probiotics and omega-3 as compared to probiotics alone.

Evaluating Changes in Omega-3 Fatty Acid Intake after Receiving Personal FADS1 Genetic Information: A Randomized Nutrigenetic Intervention.

PubMed

Roke, Kaitlin; Walton, Kathryn; Klingel, Shannon L; Harnett, Amber; Subedi, Sanjeena; Haines, Jess; Mutch, David M

2017-03-06

Nutrigenetics research is anticipated to lay the foundation for personalized dietary recommendations; however, it remains unclear if providing individuals with their personal genetic information changes dietary behaviors. Our objective was to evaluate if providing information for a common variant in the fatty acid desaturase 1 ( FADS1 ) gene changed omega-3 fatty acid (FA) intake and blood levels in young female adults (18-25 years). Participants were randomized into Genetic (intervention) and Non-Genetic (control) groups, with measurements taken at Baseline and Final (12 weeks). Dietary intake of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) was assessed using an omega-3 food frequency questionnaire. Red blood cell (RBC) FA content was quantified by gas chromatography. Implications of participation in a nutrigenetics study and awareness of omega-3 FAs were assessed with online questionnaires. Upon completion of the study, EPA and DHA intake increased significantly ( p = 1.0 × 10 -4 ) in all participants. This change was reflected by small increases in RBC %EPA. Participants in the Genetic group showed increased awareness of omega-3 terminology by the end of the study, reported that the dietary recommendations were more useful, and rated cost as a barrier to omega-3 consumption less often than those in the Non-Genetic group. Providing participants FADS1 genetic information did not appear to influence omega-3 intake during the 12 weeks, but did change perceptions and behaviors related to omega-3 FAs in this timeframe.

Omega-3 Fatty Acids Attenuate Brain Alterations in High-Fat Diet-Induced Obesity Model.

PubMed

de Mello, Aline Haas; Schraiber, Rosiane de Bona; Goldim, Mariana Pereira de Souza; Garcez, Michelle Lima; Gomes, Maria Luiza; de Bem Silveira, Gustavo; Zaccaron, Rubya Pereira; Schuck, Patrícia Fernanda; Budni, Josiane; Silveira, Paulo Cesar Lock; Petronilho, Fabricia; Rezin, Gislaine Tezza

2018-05-04

This study evaluated the effects of omega-3 on inflammation, oxidative stress, and energy metabolism parameters in the brain of mice subjected to high-fat diet-induced obesity model. Body weight and visceral fat weight were evaluated as well. Male Swiss mice were divided into control (purified low-fat diet) and obese (purified high-fat diet). After 6 weeks, the groups were divided into control + saline, control + omega-3, obese + saline, and obese + OMEGA-3. Fish oil (400 mg/kg/day) or saline solution was administrated orally, during 4 weeks. When the experiment completed 10 weeks, the animals were euthanized and the brain and visceral fat were removed. The brain structures (hypothalamus, hippocampus, prefrontal cortex, and striatum) were isolated. Treatment with omega-3 had no effect on body weight, but reduced the visceral fat. Obese animals showed increased inflammation, increased oxidative damage, decreased antioxidant enzymes activity and levels, changes in the Krebs cycle enzyme activities, and inhibition of mitochondrial respiratory chain complexes in the brain structures. Omega-3 treatment partially reversed the changes in the inflammatory and in the oxidative damage parameters and attenuated the alterations in the antioxidant defense and in the energy metabolism (Krebs cycle and mitochondrial respiratory chain). Omega-3 had a beneficial effect on the brain of obese animals, as it partially reversed the changes caused by the consumption of a high-fat diet and consequent obesity. Our results support studies that indicate omega-3 may contribute to obesity treatment.

Evaluating Changes in Omega-3 Fatty Acid Intake after Receiving Personal FADS1 Genetic Information: A Randomized Nutrigenetic Intervention

PubMed Central

Roke, Kaitlin; Walton, Kathryn; Klingel, Shannon L.; Harnett, Amber; Subedi, Sanjeena; Haines, Jess; Mutch, David M.

2017-01-01

Nutrigenetics research is anticipated to lay the foundation for personalized dietary recommendations; however, it remains unclear if providing individuals with their personal genetic information changes dietary behaviors. Our objective was to evaluate if providing information for a common variant in the fatty acid desaturase 1 (FADS1) gene changed omega-3 fatty acid (FA) intake and blood levels in young female adults (18–25 years). Participants were randomized into Genetic (intervention) and Non-Genetic (control) groups, with measurements taken at Baseline and Final (12 weeks). Dietary intake of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) was assessed using an omega-3 food frequency questionnaire. Red blood cell (RBC) FA content was quantified by gas chromatography. Implications of participation in a nutrigenetics study and awareness of omega-3 FAs were assessed with online questionnaires. Upon completion of the study, EPA and DHA intake increased significantly (p = 1.0 × 10−4) in all participants. This change was reflected by small increases in RBC %EPA. Participants in the Genetic group showed increased awareness of omega-3 terminology by the end of the study, reported that the dietary recommendations were more useful, and rated cost as a barrier to omega-3 consumption less often than those in the Non-Genetic group. Providing participants FADS1 genetic information did not appear to influence omega-3 intake during the 12 weeks, but did change perceptions and behaviors related to omega-3 FAs in this timeframe. PMID:28272299

A proposed microcomputer implementation of an Omega navigation processor

NASA Technical Reports Server (NTRS)

Abel, J. D.

1976-01-01

A microprocessor navigation systems using the Omega process is discussed. Several methods for correcting incoming sky waves are presented along with the hardware design which depends on a microcomputer. The control program is discussed, and block diagrams of the Omega processor and interface systems are presented.

21 CFR 177.1680 - Polyurethane resins.

Code of Federal Regulations, 2012 CFR

2012-04-01

...′,α″-1,2,3-Propanetriyltris [omega-hydroxypoly (oxypropylene) (15-18 moles)], average molecular weight 3,000. Propylene glycol. α,α′,α″-[Propylidynetris (methylene)] tris [omega-hydroxypoly (oxypropylene) (minimum 1.5 moles)], minimum molecular weight 400. α-[ρ(1,1,3,3-Tetramethylbutyl) - phenyl]-omega...

21 CFR 177.1680 - Polyurethane resins.

Code of Federal Regulations, 2011 CFR

2011-04-01

...′,α″-1,2,3-Propanetriyltris [omega-hydroxypoly (oxypropylene) (15-18 moles)], average molecular weight 3,000. Propylene glycol. α,α′,α″-[Propylidynetris (methylene)] tris [omega-hydroxypoly (oxypropylene) (minimum 1.5 moles)], minimum molecular weight 400. α-[ρ(1,1,3,3-Tetramethylbutyl) - phenyl]-omega...

21 CFR 177.1680 - Polyurethane resins.

Code of Federal Regulations, 2010 CFR

2010-04-01

...′,α″-1,2,3-Propanetriyltris [omega-hydroxypoly (oxypropylene) (15-18 moles)], average molecular weight 3,000. Propylene glycol. α,α′,α″-[Propylidynetris (methylene)] tris [omega-hydroxypoly (oxypropylene) (minimum 1.5 moles)], minimum molecular weight 400. α-[ρ(1,1,3,3-Tetramethylbutyl) - phenyl]-omega...

21 CFR 177.1680 - Polyurethane resins.

Code of Federal Regulations, 2013 CFR

2013-04-01

...′,α″-1,2,3-Propanetriyltris [omega-hydroxypoly (oxypropylene) (15-18 moles)], average molecular weight 3,000. Propylene glycol. α,α′,α″-[Propylidynetris (methylene)] tris [omega-hydroxypoly (oxypropylene) (minimum 1.5 moles)], minimum molecular weight 400. α-[ρ(1,1,3,3-Tetramethylbutyl) - phenyl]-omega...

Omega-3 fatty acids (from fish oils) for cystic fibrosis.

PubMed

McKarney, C; Everard, M; N'Diaye, T

2007-10-17

Epidemiological and other studies suggest that a diet rich in omega-3 essential fatty acids (derived from fish oil) may have beneficial anti-inflammatory effects for chronic conditions such as cystic fibrosis (CF). To determine whether there is evidence that omega-3 polyunsaturated fatty acid supplementation reduces morbidity and mortality. To identify any adverse events associated with omega-3 polyunsaturated fatty acid supplementation. We searched the Cochrane Cystic Fibrosis and Genetic Disorders Group's Trials Register comprising references identified from comprehensive electronic database searches and handsearches of relevant journals and abstract books of conference proceedings. Authors and persons interested in the subject of the review were contacted. Most recent search: April 2007 Randomised controlled trials in people with CF comparing omega-3 fatty acid supplements with placebo. Two authors independently selected the studies for inclusion in the review, independently extracted data and assessed the methodological quality of the studies. Searches identified seven studies; three of which, involving 48 participants, were eligible for inclusion in the review. Two studies compared omega-3 fatty acids to olive oil controls for a six-week treatment period. One study compared omega-3 fatty acids in the form of a liquid dietary supplement containing polyunsaturated fatty acids to a liquid dietary supplement control for six months. One short-term study (19 participants) comparing omega-3 to placebo reported a significant improvement in forced expiratory volume in one second, forced vital capacity and Shwachman score and a reduction in sputum volume in the omega-3 group. The longer-term study (17 participants) demonstrated a significant increase in essential fatty acid content in neutrophil membranes in study participants taking omega-3 supplements compared to placebo, weighted mean difference 0.90 (95% confidence interval 0.46 to 1.34). This review found that regular omega-3 supplements may provide some benefits for people with CF with relatively few adverse effects, although the evidence is insufficient to draw firm conclusions or to recommend routine use of supplements of omega-3 fatty acids in people with CF. This review has highlighted the lack of data for many of the outcomes likely to be meaningful to people with or making treatment decisions about CF. A large, long-term, multicentre, randomised controlled study is needed in order to determine if there is a significant therapeutic effect and to assess the influence of disease severity, dosage and duration of treatment. Future researchers should note the need for additional pancreatic enzymes.

Omega-3 fatty acids in health and disease and in growth and development.

PubMed

Simopoulos, A P

1991-09-01

Several sources of information suggest that man evolved on a diet with a ratio of omega 6 to omega 3 fatty acids of approximately 1 whereas today this ratio is approximately 10:1 to 20-25:1, indicating that Western diets are deficient in omega 3 fatty acids compared with the diet on which humans evolved and their genetic patterns were established. Omega-3 fatty acids increase bleeding time; decrease platelet aggregation, blood viscosity, and fibrinogen; and increase erythrocyte deformability, thus decreasing the tendency to thrombus formation. In no clinical trial, including coronary artery graft surgery, has there been any evidence of increased blood loss due to ingestion of omega 3 fatty acids. Many studies show that the effects of omega 3 fatty acids on serum lipids depend on the type of patient and whether the amount of saturated fatty acids in the diet is held constant. In patients with hyperlipidemia, omega 3 fatty acids decrease low-density-lipoprotein (LDL) cholesterol if the saturated fatty acid content is decreased, otherwise there is a slight increase, but at high doses (32 g) they lower LDL cholesterol; furthermore, they consistently lower serum triglycerides in normal subjects and in patients with hypertriglyceridemia whereas the effect on high-density lipoprotein (HDL) varies from no effect to slight increases. The discrepancies between animal and human studies most likely are due to differences between animal and human metabolism. In clinical trials eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in the form of fish oils along with antirheumatic drugs improve joint pain in patients with rheumatoid arthritis; have a beneficial effect in patients with ulcerative colitis; and in combination with drugs, improve the skin lesions, lower the hyperlipidemia from etretinates, and decrease the toxicity of cyclosporin in patients with psoriasis. In various animal models omega 3 fatty acids decrease the number and size of tumors and increase the time elapsed before appearance of tumors. Studies with nonhuman primates and human newborns indicate that DHA is essential for the normal functional development of the retina and brain, particularly in premature infants. Because omega 3 fatty acids are essential in growth and development throughout the life cycle, they should be included in the diets of all humans. Omega-3 and omega 6 fatty acids are not interconvertible in the human body and are important components of practically all cell membranes. Whereas cellular proteins are genetically determined, the polyunsaturated fatty acid (PUFA) composition of cell membranes is to a great extent dependent on the dietary intake.(ABSTRACT TRUNCATED AT 400 WORDS)

21 CFR 177.1680 - Polyurethane resins.

Code of Federal Regulations, 2014 CFR

2014-04-01

...′-(Isopropylidenedi-p-phenylene)bis[omega-hydroxypoly (oxy-pro-pylene)(3-4 moles)], average molecular weight 675... propylene oxide). Polypropylene glycol. α,α′,α″-1,2,3-Propanetriyltris [omega-hydroxypoly (oxypropylene) (15...)] tris [omega-hydroxypoly (oxypropylene) (minimum 1.5 moles)], minimum molecular weight 400. α-[ρ(1,1,3,3...

Functional beverage products using caseinate–omega-3 oil-oat beta glucan emulsions

USDA-ARS?s Scientific Manuscript database

Beverages with soluble dietary fiber and Omega 3 oil are highly desired by health conscious consumers. However, Omega 3 oil is prone to oxidation and accompanying deterioration of sensory profiles; there is an issue to incorporate soluble fiber into beverage products that will not interfere with oxi...

Pasting and rheological properties of chia composites containing barley flour

USDA-ARS?s Scientific Manuscript database

The chia containing omega-3 polyunsaturated fatty acids (omega-3 PUFAs) was composited with barley flour having high ß-glucan content. Both omega-3 PUFAs and ß-glucan are well known for lowering blood cholesterol and preventing coronary heart disease. Barley flour was dry blended with ground chia ...

40 CFR 721.10121 - Poly[oxy(methyl-1,2-ethanediyl)], .alpha.-methyl-.omega.-(4-nonylphenoxy)-, branched.

Code of Federal Regulations, 2012 CFR

2012-07-01

...)], .alpha.-methyl-.omega.-(4-nonylphenoxy)-, branched. 721.10121 Section 721.10121 Protection of Environment...)], .alpha.-methyl-.omega.-(4-nonylphenoxy)-, branched. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified as poly[oxy(methyl-1,2-ethanediyl)], .alpha...

40 CFR 721.10121 - Poly[oxy(methyl-1,2-ethanediyl)], .alpha.-methyl-.omega.-(4-nonylphenoxy)-, branched.

Code of Federal Regulations, 2010 CFR

2010-07-01

...)], .alpha.-methyl-.omega.-(4-nonylphenoxy)-, branched. 721.10121 Section 721.10121 Protection of Environment...)], .alpha.-methyl-.omega.-(4-nonylphenoxy)-, branched. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified as poly[oxy(methyl-1,2-ethanediyl)], .alpha...

40 CFR 721.10121 - Poly[oxy(methyl-1,2-ethanediyl)], .alpha.-methyl-.omega.-(4-nonylphenoxy)-, branched.

Code of Federal Regulations, 2013 CFR

2013-07-01

...)], .alpha.-methyl-.omega.-(4-nonylphenoxy)-, branched. 721.10121 Section 721.10121 Protection of Environment...)], .alpha.-methyl-.omega.-(4-nonylphenoxy)-, branched. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified as poly[oxy(methyl-1,2-ethanediyl)], .alpha...

40 CFR 721.10121 - Poly[oxy(methyl-1,2-ethanediyl)], .alpha.-methyl-.omega.-(4-nonylphenoxy)-, branched.

Code of Federal Regulations, 2014 CFR

2014-07-01

...)], .alpha.-methyl-.omega.-(4-nonylphenoxy)-, branched. 721.10121 Section 721.10121 Protection of Environment...)], .alpha.-methyl-.omega.-(4-nonylphenoxy)-, branched. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified as poly[oxy(methyl-1,2-ethanediyl)], .alpha...

40 CFR 721.10121 - Poly[oxy(methyl-1,2-ethanediyl)], .alpha.-methyl-.omega.-(4-nonylphenoxy)-, branched.

Code of Federal Regulations, 2011 CFR

2011-07-01

...)], .alpha.-methyl-.omega.-(4-nonylphenoxy)-, branched. 721.10121 Section 721.10121 Protection of Environment...)], .alpha.-methyl-.omega.-(4-nonylphenoxy)-, branched. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified as poly[oxy(methyl-1,2-ethanediyl)], .alpha...

Organogel as an approach to protect omega-3 oils from oxidation

USDA-ARS?s Scientific Manuscript database

The global omega-3 oil market is steadily growing due to their beneficial health effects. However, it has been challenging to prevent oxidation of omega-3 oils since their polyunsaturated fats are very prone to oxidation during manufacturing processes, transportation, and storage. Organogels have ga...

Diurnal measurements with prototype CMOS Omega receivers

NASA Technical Reports Server (NTRS)

Burhans, R. W.

1976-01-01

Diurnal signals from eight omega channels have been monitored at 10.2 KHz for selected station pairs. All eight Omega stations have been received at least 50 percent of the time over a 24 hour period during the month of October 1976. The data presented confirm the expected performance of the CMOS omega sensor processor in being able to digsignals out of a noisy environment. Of particular interest are possibilities for use of antipodal reception phenomena and a need for some ways of correcting for multi-modal propagation effects.

A vectorized Poisson solver over a spherical shell and its application to the quasi-geostrophic omega-equation

NASA Technical Reports Server (NTRS)

Mullenmeister, Paul

1988-01-01

The quasi-geostrophic omega-equation in flux form is developed as an example of a Poisson problem over a spherical shell. Solutions of this equation are obtained by applying a two-parameter Chebyshev solver in vector layout for CDC 200 series computers. The performance of this vectorized algorithm greatly exceeds the performance of its scalar analog. The algorithm generates solutions of the omega-equation which are compared with the omega fields calculated with the aid of the mass continuity equation.

Enhancements to the timing of the OMEGA laser system to improve illumination uniformity

NASA Astrophysics Data System (ADS)

Donaldson, W. R.; Katz, J.; Kosc, T. Z.; Kelly, J. H.; Hill, E. M.; Bahr, R. E.

2016-09-01

Two diagnostics have been developed to improve the uniformity on the OMEGA Laser System, which is used for inertial confinement fusion (ICF) research. The first diagnostic measures the phase of an optical modulator (used for the spectral dispersion technique employed on OMEGA to enhance spatial smoothing), which adds bandwidth to the optical pulse. Setting this phase precisely is required to reduce pointing errors. The second diagnostic ensures that the arrival times of all the beams are synchronized. The arrival of each of the 60 OMEGA beams is measured by placing a 1-mm diffusing sphere at target chamber center. By comparing the arrival time of each beam with respect to a reference pulse, the measured timing spread of the OMEGA Laser System is now 3.8 ps.

Two omega method for active thermocouple microscopy.

PubMed

Thiery, Laurent; Gavignet, Eric; Cretin, Bernard

2009-03-01

We present a contribution to a new mode of scanning thermal microscopy (SThM) based on the use of thermoelectric junction operating in ac active mode. This is the first alternative to 3omega operating mode of a resistive SThM probe for measuring thermophysical parameters of materials at micro- and nanoscale. Whereas a current at omega frequency generates by Joule effect a 2omega thermal oscillation along the wires, the junction thermoelectric voltage can be measured by means of a differential bridge scheme associated to a lock-in amplifier. A thermal model is presented that confirms measurements performed in different situations with different wire probes. Values of thermal contact conductance of different materials have been extracted and a comparison has been performed between this technique and the resistive 3omega mode.

Potential adverse effects of omega-3 Fatty acids in dogs and cats.

PubMed

Lenox, C E; Bauer, J E

2013-01-01

Fish oil omega-3 fatty acids, mainly eicosapentaenoic acid and docosahexaenoic acid, are used in the management of several diseases in companion animal medicine, many of which are inflammatory in nature. This review describes metabolic differences among omega-3 fatty acids and outlines potential adverse effects that may occur with their supplementation in dogs and cats with a special focus on omega-3 fatty acids from fish oil. Important potential adverse effects of omega-3 fatty acid supplementation include altered platelet function, gastrointestinal adverse effects, detrimental effects on wound healing, lipid peroxidation, potential for nutrient excess and toxin exposure, weight gain, altered immune function, effects on glycemic control and insulin sensitivity, and nutrient-drug interactions. Copyright © 2013 by the American College of Veterinary Internal Medicine.

Omega-3 Polyunsaturated Fatty Acids and Their Health Benefits.

PubMed

Shahidi, Fereidoon; Ambigaipalan, Priyatharini

2018-03-25

Omega-3 polyunsaturated fatty acids (PUFAs) include α-linolenic acid (ALA; 18:3 ω-3), stearidonic acid (SDA; 18:4 ω-3), eicosapentaenoic acid (EPA; 20:5 ω-3), docosapentaenoic acid (DPA; 22:5 ω-3), and docosahexaenoic acid (DHA; 22:6 ω-3). In the past few decades, many epidemiological studies have been conducted on the myriad health benefits of omega-3 PUFAs. In this review, we summarized the structural features, properties, dietary sources, metabolism, and bioavailability of omega-3 PUFAs and their effects on cardiovascular disease, diabetes, cancer, Alzheimer's disease, dementia, depression, visual and neurological development, and maternal and child health. Even though many health benefits of omega-3 PUFAs have been reported in the literature, there are also some controversies about their efficacy and certain benefits to human health.

Helicons, magnetoplasma edge, and faraday rotation in solid state plasmas at microwave frequencies.

PubMed

Furdyna, J K

1967-04-01

The effect of magnetic field on propagation of electromagnetic waves through free carrier plasmas in semiconductors is discussed. The Faraday configuration and the parameter ranges omega(c),omega(p) > omega and omega(c) > tau(-1) are specifically considered. Dispersion of helicon waves, propagation near the magnetoplasma edge (omega(p)(2) = omegaomega(c)), and the Faraday rotation are developed in terms of the one-electron Drude theory. Microwave transmission measurements at 35 Gc/s on n-type InSb are presented. Experiments near the magnetoplasma edge yield the value of the static dielectric constant of the InSb lattice K(l) = 19.3 +/- 0.8. Faraday rotation, observed beyond the edge, is found to be extremely large. Some practical possibilities for this effect are considered.

Carbon monoxide inhibits omega-oxidation of leukotriene B4 by human polymorphonuclear leukocytes: evidence that catabolism of leukotriene B4 is mediated by a cytochrome P-450 enzyme.

PubMed

Shak, S; Goldstein, I M

1984-09-17

Carbon monoxide significantly inhibits omega-oxidation of exogenous leukotriene B4 to 20-OH-leukotriene B4 and 20-COOH-leukotriene B4 by unstimulated polymorphonuclear leukocytes as well as omega-oxidation of leukotriene B4 that is generated when cells are stimulated with the calcium ionophore, A23187. Inhibition of omega-oxidation by carbon monoxide is concentration-dependent, completely reversible, and specific. Carbon monoxide does not affect synthesis of leukotriene B4 by stimulated polymorphonuclear leukocytes or other cell functions (i.e., degranulation, superoxide anion generation). These findings suggest that a cytochrome P-450 enzyme in human polymorphonuclear leukocytes is responsible for catabolizing leukotriene B4 by omega-oxidation.

Dietary sources of omega 3 fatty acids: public health risks and benefits.

PubMed

Tur, J A; Bibiloni, M M; Sureda, A; Pons, A

2012-06-01

Omega 3 fatty acids can be obtained from several sources, and should be added to the daily diet to enjoy a good health and to prevent many diseases. Worldwide, general population use omega-3 fatty acid supplements and enriched foods to get and maintain adequate amounts of these fatty acids. The aim of this paper was to review main scientific evidence regarding the public health risks and benefits of the dietary sources of omega-3 fatty acids. A systematic literature search was performed, and one hundred and forty-five articles were included in the results for their methodological quality. The literature described benefits and risks of algal, fish oil, plant, enriched dairy products, animal-derived food, krill oil, and seal oil omega-3 fatty acids.

Understanding the Impact of Omega-3 Rich Diet on the Gut Microbiota

PubMed Central

Noriega, Blanca S.; Salyakina, Daria; Coffman, Jonathan

2016-01-01

Background. Recently, the importance of the gut microbiota in the pathogenesis of several disorders has gained clinical interests. Among exogenous factors affecting gut microbiome, diet appears to have the largest effect. Fatty acids, especially omega-3 polyunsaturated, ameliorate a range of several diseases, including cardiometabolic and inflammatory and cancer. Fatty acids associated beneficial effects may be mediated, to an important extent, through changes in gut microbiota composition. We sought to understand the changes of the gut microbiota in response to an omega-3 rich diet. Case Presentation. This case study investigated changes of gut microbiota with an omega-3 rich diet. Fecal samples were collected from a 45-year-old male who consumed 600 mg of omega-3 daily for 14 days. After the intervention, species diversity was decreased, but several butyrate-producing bacteria increased. There was an important decrease in Faecalibacterium prausnitzii and Akkermansia spp. Gut microbiota changes were reverted after the 14-day washout. Conclusion. Some of the health-related benefits of omega-3 may be due, in part, to increases in butyrate-producing bacteria. These findings may shed light on the mechanisms explaining the effects of omega-3 in several chronic diseases and may also serve as an existing foundation for tailoring personalized medical treatments. PMID:27065349

Impact of Omega-3 Fatty Acids on the Gut Microbiota

PubMed Central

Farinon, Barbara

2017-01-01

Long-term dietary habits play a crucial role in creating a host-specific gut microbiota community in humans. Despite the many publications about the effects of carbohydrates (prebiotic fibers), the impact of dietary fats, such as omega-3 polyunsaturated fatty acids (PUFAs), on the gut microbiota is less well defined. The few studies completed in adults showed some common changes in the gut microbiota after omega-3 PUFA supplementation. In particular, a decrease in Faecalibacterium, often associated with an increase in the Bacteroidetes and butyrate-producing bacteria belonging to the Lachnospiraceae family, has been observed. Coincidentally, a dysbiosis of these taxa is found in patients with inflammatory bowel disease. Omega-3 PUFAs can exert a positive action by reverting the microbiota composition in these diseases, and increase the production of anti-inflammatory compounds, like short-chain fatty acids. In addition, accumulating evidence in animal model studies indicates that the interplay between gut microbiota, omega-3 fatty acids, and immunity helps to maintain the intestinal wall integrity and interacts with host immune cells. Finally, human and animal studies have highlighted the ability of omega-3 PUFAs to influence the gut–brain axis, acting through gut microbiota composition. From these findings, the importance of the omega-3 connection to the microbiota emerges, encouraging further studies. PMID:29215589

Theory of hydro-equivalent ignition for inertial fusion and its applications to OMEGA and the National Ignition Facility

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nora, R.; Betti, R.; Bose, A.

The theory of ignition for inertial confinement fusion capsules [R. Betti et al., Phys. Plasmas 17, 058102 (2010)] is used to assess the performance requirements for cryogenic implosion experiments on the Omega Laser Facility. The theory of hydrodynamic similarity is developed in both one and two dimensions and tested using multimode hydrodynamic simulations with the hydrocode DRACO [P. B. Radha et al., Phys. Plasmas 12, 032702 (2005)] of hydro-equivalent implosions (implosions with the same implosion velocity, adiabat, and laser intensity). The theory is used to scale the performance of direct-drive OMEGA implosions to the National Ignition Facility (NIF) energy scalesmore » and determine the requirements for demonstrating hydro-equivalent ignition on OMEGA. Hydro-equivalent ignition on OMEGA is represented by a cryogenic implosion that would scale to ignition on the NIF at 1.8 MJ of laser energy symmetrically illuminating the target. It is found that a reasonable combination of neutron yield and areal density for OMEGA hydro-equivalent ignition is 3 to 6 × 10{sup 13} and ∼0.3 g/cm{sup 2}, respectively, depending on the level of laser imprinting. This performance has not yet been achieved on OMEGA.« less

The Effect of Omega-3 on Circulating Adiponectin in Adults with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

PubMed

Bahreini, Mehdi; Ramezani, Amir-Hossein; Shishehbor, Farideh; Mansoori, Anahita

2018-01-04

Whether consumption of omega-3 affects circulating adiponectin has not been established. The objective of this study was to evaluate the effect of omega-3 (food or supplement) on circulating adiponectin in patients with type 2 diabetes through a systematic review of meta-analyses of randomized controlled trials. PubMed, Scopus and Web of Science were searched for relevant studies through May 2016. Two researchers screened and abstracted the literature independently. Pooled estimates were obtained using the random-effects models. Overall, omega-3 increased adiponectin by 0.57 µg/mL (95% confidence interval [CI] 0.15 to 1.31; p=0.01, I-square=74.2% p for heterogeneity <0.001). The source of observed heterogeneity was explored by subgroup analyses. In subgroup analyses, adiponectin levels increased only in those who had consumed omega-3 for more than 8 weeks. This systematic review and meta-analysis of randomized, placebo-controlled clinical trials suggests that omega-3 in patients with type 2 diabetes increases circulating adiponectin. These findings support the potentially beneficial effects of dietary omega-3 in patients with type 2 diabetes on pathways related to adiponectin metabolism. Copyright © 2017 Diabetes Canada. Published by Elsevier Inc. All rights reserved.

Omega-3 Fatty Acids and Skeletal Muscle Health

PubMed Central

Jeromson, Stewart; Gallagher, Iain J.; Galloway, Stuart D. R.; Hamilton, D. Lee

2015-01-01

Skeletal muscle is a plastic tissue capable of adapting and mal-adapting to physical activity and diet. The response of skeletal muscle to adaptive stimuli, such as exercise, can be modified by the prior nutritional status of the muscle. The influence of nutrition on skeletal muscle has the potential to substantially impact physical function and whole body metabolism. Animal and cell based models show that omega-3 fatty acids, in particular those of marine origin, can influence skeletal muscle metabolism. Furthermore, recent human studies demonstrate that omega-3 fatty acids of marine origin can influence the exercise and nutritional response of skeletal muscle. These studies show that the prior omega-3 status influences not only the metabolic response of muscle to nutrition, but also the functional response to a period of exercise training. Omega-3 fatty acids of marine origin therefore have the potential to alter the trajectory of a number of human diseases including the physical decline associated with aging. We explore the potential molecular mechanisms by which omega-3 fatty acids may act in skeletal muscle, considering the n-3/n-6 ratio, inflammation and lipidomic remodelling as possible mechanisms of action. Finally, we suggest some avenues for further research to clarify how omega-3 fatty acids may be exerting their biological action in skeletal muscle. PMID:26610527

Technological trends and market perspectives for production of microbial oils rich in omega-3.

PubMed

Finco, Ana Maria de Oliveira; Mamani, Luis Daniel Goyzueta; Carvalho, Júlio Cesar de; de Melo Pereira, Gilberto Vinícius; Thomaz-Soccol, Vanete; Soccol, Carlos Ricardo

2017-08-01

In recent years, foods that contain omega-3 lipids have emerged as important promoters of human health. These lipids are essential for the functional development of the brain and retina, and reduction of the risk of cardiovascular and Alzheimer's diseases. The global market for omega-3 production, particularly docosahexaenoic acid (DHA), saw a large expansion in the last decade due to the increasing use of this lipid as an important component of infant food formulae and supplements. The production of omega-3 lipids from fish and vegetable oil sources has some drawbacks, such as complex purification procedures, unwanted contamination by marine pollutants, reduction or even extinction of several species of fish, and aspects related to sustainability. A promising alternative system for the production of omega-3 lipids is from microbial metabolism of yeast, fungi, or microalgae. The aim of this review is to discuss the various omega-3 sources in the context of the global demand and market potential for these bioactive compounds. To summarize, it is clear that fish and vegetable oil sources will not be sufficient to meet the future needs of the world population. The biotechnological production of single-cell oil comes as a sustainable alternative capable of supplementing the global demand for omega-3, causing less environmental impact.

Efficient optical nonlinear Langmuir-Blodgett films: roles of matrix molecules

NASA Astrophysics Data System (ADS)

Ma, Shihong; Lu, Xingze; Liu, Liying; Han, Kui; Wang, Wencheng; Zhang, Zhi-Ming

1996-10-01

A novel bifat-chain amphiphilic molecule nitrogencrown (NC) was adopted as an inert material for fabrication of optical nonlinear Langmuir-Blodgett (LB) multilayers. Structural improvement in the Z-type mixed fullerene derivative (C60-Be)/NC LB multilayers samples was realized by insertion of the C60-Be molecules between two hydrophobic chains of the NC molecules. The relatively large third-order susceptibility (chi) (3)xxxx(- 3(omega) ;(omega) ,(omega) ,(omega) ) equals 2.9 multiplied by 10-19 M2V-2 (or 2.1 multiplied by 10-11 esu) was deduced by measuring third harmonic generation (THG) from the C60-Be samples. The second harmonic generation (SHG) intensity increased quadratically with the bilayer number (up to 116 bilayers) in Y-type hemicyanine (HEM)/NC interleaving LB multilayers due to improvement of the structural properties by insertion of the long hydrophobic tail of HEM molecules between two chains of NC molecules. The second-order susceptibility (chi) (2)zxx(-2(omega) ;(omega) ,(omega) ) equals 18 pM V-1 (or 4.35 multiplied by 10-8 esu) was obtained by measuring SHG from the HEM samples. The NC molecule has attractive features as a matrix material in fabrications of LB multilayers made from optically nonlinear materials with hydrophobic long tails or ball-like molecules.

Effects of oral supplementation with omega-3 fatty acids on nutritional state and inflammatory markers in maintenance hemodialysis patients.

PubMed

Gharekhani, Afshin; Khatami, Mohammad-Reza; Dashti-Khavidaki, Simin; Razeghi, Effat; Abdollahi, Alireza; Hashemi-Nazari, Seyed-Saeed; Mansournia, Mohammad-Ali

2014-05-01

The objective was to determine the effects of omega-3 supplementation on nutritional state and inflammatory markers of hemodialysis patients. This was a randomized, placebo-controlled trial. Adult patients undergoing maintenance hemodialysis were included. Patients with malignancy, pregnancy, concurrent inflammatory or infectious diseases, or concomitant use of any medication affecting inflammation status were excluded. The omega-3 group received 6 soft-gel capsules of fish oil (180 mg eicosapentaenoic acid and 120 mg docosahexaenoic acid in each) daily for 4 months, and the placebo group received corresponding paraffin oil capsules.Nutrition indices including body mass index; mid-arm muscle circumference; serum concentrations of albumin, prealbumin, and transferrin; and serum levels of inflammatory/anti-inflammatory markers including interleukin (IL)-6, IL-10, tumor necrosis factor (TNF)-α, C-reactive protein, ferritin, parathyroid hormone, and ratios of IL-10 to TNF-α and IL-10 to IL-6 were measured before and after 4 months of intervention. Twenty patients in the placebo and 25 patients in the omega-3 group completed the study. There were no significant changes in nutritional markers between the omega-3 and placebo groups after 4 months of intervention. Regression analysis adjusting post-treatment values of nutrition markers for baseline values, omega-3 treatment, and patients' baseline demographic and clinical data revealed that omega-3 treatment was a significant independent predictor of increased serum prealbumin level (182.53; 95% confidence interval 21.14, 511.18; P = .11). Although slight reduction of inflammatory state was observed in the omega-3 group, no significant differences were evident in the mean changes of inflammatory and anti-inflammatory markers between the 2 groups with the exception of serum ferritin level and the IL-10 to IL-6 ratio, which significantly changed in favor of omega-3 supplementation (P < .001 and P = .003, respectively). Omega-3 supplementation in hemodialysis patients produced a slight attenuation in systemic inflammation without any remarkable effects on nutritional markers. Copyright © 2014 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.

Inhibitory effects of omega-3 fatty acids on early brain injury after subarachnoid hemorrhage in rats: Possible involvement of G protein-coupled receptor 120/β-arrestin2/TGF-β activated kinase-1 binding protein-1 signaling pathway.

PubMed

Yin, Jia; Li, Haiying; Meng, Chengjie; Chen, Dongdong; Chen, Zhouqing; Wang, Yibin; Wang, Zhong; Chen, Gang

2016-06-01

Omega-3 fatty acids have been reported to improve neuron functions during aging and in patients affected by mild cognitive impairment, and mediate potent anti-inflammatory via G protein-coupled receptor 120 (GPR120) signal pathway. Neuron dysfunction and inflammatory response also contributed to the progression of subarachnoid hemorrhage (SAH)-induced early brain injury (EBI). This study was to examine the effects of omega-3 fatty acids on SAH-induced EBI. Two weeks before SAH, 30% Omega-3 fatty acids was administered by oral gavage at 1g/kg body weight once every 24h. Specific siRNA for GPR120 was exploited. Terminal deoxynucleotidyl transferase dUTP nick end labeling, fluoro-Jade B staining, and neurobehavioral scores and brain water content test showed that omega-3 fatty acids effectively suppressed SAH-induced brain cell apoptosis and neuronal degradation, behavioral impairment, and brain edema. Western blot, immunoprecipitation, and electrophoretic mobility shift assays results showed that omega-3 fatty acids effectively suppressed SAH-induced elevation of inflammatory factors, including cyclooxygenase-2, monocyte chemoattractant protein-1, and inducible nitric oxide synthase. In addition, omega-3 fatty acids could inhibit phosphorylation of transforming growth factor β activated kinase-1 (TAK1), MEK4, c-Jun N-terminal kinase, and IkappaB kinase as well as activation of nuclear factor kappa B through regulating GPR120/β-arrestin2/TAK1 binding protein-1 pathway. Furthermore, siRNA-induced GPR120 silencing blocked the protective effects of omega-3 fatty acids. Here, we show that stimulation of GPR120 with omega-3 fatty acids pretreatment causes anti-apoptosis and anti-inflammatory effects via β-arrestin2/TAK1 binding protein-1/TAK1 pathway in the brains of SAH rats. Fish omega-3 fatty acids as part of a daily diet may reduce EBI in an experimental rat model of SAH. Copyright © 2016 Elsevier Ltd. All rights reserved.

New Constraints on Dark Energy from Chandra X-rayObservations of the Largest Relaxed Galaxy Clusters

DOE Office of Scientific and Technical Information (OSTI.GOV)

Allen, S.W.; Rapetti, D.A.; /KIPAC, Menlo Park

2007-06-06

We present constraints on the mean matter density, {Omega}{sub m}, dark energy density, {Omega}{sub DE}, and the dark energy equation of state parameter, w, using Chandra measurements of the X-ray gas mass fraction (fgas) in 42 hot (kT > 5keV), X-ray luminous, dynamically relaxed galaxy clusters spanning the redshift range 0.05 < z < 1.1. Using only the fgas data for the 6 lowest redshift clusters at z < 0.15, for which dark energy has a negligible effect on the measurements, we measure {Omega}{sub m}=0.28{+-}0.06 (68% confidence, using standard priors on the Hubble Constant, H{sub 0}, and mean baryon density,more » {Omega}{sub b}h{sup 2}). Analyzing the data for all 42 clusters, employing only weak priors on H{sub 0} and {Omega}{sub b}h{sup 2}, we obtain a similar result on {Omega}{sub m} and detect the effects of dark energy on the distances to the clusters at {approx}99.99% confidence, with {Omega}{sub DE}=0.86{+-}0.21 for a non-flat LCDM model. The detection of dark energy is comparable in significance to recent SNIa studies and represents strong, independent evidence for cosmic acceleration. Systematic scatter remains undetected in the f{sub gas} data, despite a weighted mean statistical scatter in the distance measurements of only {approx}5%. For a flat cosmology with constant w, we measure {Omega}{sub m}=0.28{+-}0.06 and w=-1.14{+-}0.31. Combining the fgas data with independent constraints from CMB and SNIa studies removes the need for priors on {Omega}{sub b}h{sup 2} and H{sub 0} and leads to tighter constraints: {Omega}{sub m}=0.253{+-}0.021 and w=-0.98{+-}0.07 for the same constant-w model. More general analyses in which we relax the assumption of flatness and/or allow evolution in w remain consistent with the cosmological constant paradigm. Our analysis includes conservative allowances for systematic uncertainties. The small systematic scatter and tight constraints bode well for future dark energy studies using the f{sub gas} method.« less

Flow Shears at the Poleward Boundary of Omega Bands Observed During Conjunctions of Swarm and THEMIS ASI

NASA Astrophysics Data System (ADS)

Liu, Jiang; Lyons, L. R.; Archer, W. E.; Gallardo-Lacourt, B.; Nishimura, Y.; Zou, Ying; Gabrielse, C.; Weygand, J. M.

2018-02-01

Omega bands are curved aurora forms that evolve from a quiet arc located along the poleward edge of a diffuse auroral band within the midnight to morningside auroral oval. They usually propagate eastward. Because omega bands are a significant contributor to an active magnetotail, knowledge about their generation is important for understanding tail dynamics. Previous studies have shown that auroral streamers, footprints of fast flows in the tail, can propagate into omega bands. Such events, however, are limited, and it is still unclear whether and how the flows trigger the bands. The ionospheric flows associated with omega bands may provide valuable information on the driving mechanisms of the bands. We examine these flows taking advantage of the conjunctions between the Swarm spacecraft and Time History of Events and Macroscale Interactions during Substorms all-sky imagers, which allow us to demonstrate the relative location of the flows to the omega bands' bright arcs for the first time. We find that a strong eastward ionospheric flow is consistently present immediately poleward of the omega band's bright arc, resulting in a sharp flow shear near the poleward boundary of the band. This ionospheric flow shear should correspond to a flow shear near the inner edge of the plasma sheet. This plasma sheet shear may drive a Kelvin-Helmholz instability which then distorts the quiet arc to form omega bands. It seems plausible that the strong eastward flows are driven by streamer-related fast flows or enhanced convection in the magnetotail.

Effect of Omega-3 Fatty Acids on Depressive Symptoms in HIV-Positive Individuals: A Randomized, Placebo-Controlled Clinical Trial.

PubMed

Ravi, Saeedeh; Khalili, Hossein; Abbasian, Ladan; Arbabi, Mohammad; Ghaeli, Padideh

2016-10-01

The antidepressant effect of omega-3 fatty acids has been described in the non-HIV population. The effect of omega-3 fatty acid supplementation on the mood status of HIV-positive patients has not been evaluated yet. In this study, the effect of omega-3 fatty acids on depressive symptoms was evaluated in HIV-positive individuals. A total of 100 HIV-positive patients with Beck Depression Score ≥16, were assigned to receive either omega-3 fatty acids or placebo twice daily for 8 weeks. Depressive symptoms of each participant were evaluated at baseline (month 0) and at the end of months 1 and 2 of the study. Beck Depression Inventory Second Edition, depression subscale of the Hospital Anxiety and Depression Scale, and Patient Health Questionnaire were used for assessment of depressive symptoms. Reduction in mean ± SD of all depression scores during the study period was statistically significant within the omega-3 group and when compared with the placebo group (for both comparisons, P < 0.001). Also, the mean differences of all depression scores were decreased significantly during the intervals: months 0, 1, and 2 (P < 0.001 for all comparisons). Among the participants, 7 (7%) and 4 (4%) patients in the omega-3 and the placebo group, respectively, experienced mild gastrointestinal problems, but the incidence of adverse drug reactions related to the interventions was not statistically different between the groups (P = 0.09). Omega-3 fatty acids improved depressive symptoms in HIV-positive individuals without any significant adverse reaction. © The Author(s) 2016.

Resonances in the optical response of a slab with time-periodic dielectric function {epsilon}(t)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zurita-Sanchez, Jorge R.; Halevi, P.

2010-05-15

We demonstrate that the optical response of a periodically modulated dynamic slab exhibits infinite resonances for frequencies {omega}=({Omega}/2)(2l+1), namely, odd multiples of one-half of the modulating frequency {Omega} of the dielectric function {epsilon}(t). These frequencies coincide partially with the usual condition of parametric amplification. However, the resonances occur only for certain normalized slab thicknesses L{sub R}. These resonances follow from detailed numerical studies based on our recent paper [Zurita-Sanchez, Halevi, and Cervantes-Gonzalez, Phys. Rev. A 79, 053821 (2009)]. As the thickness L nearly matches a resonance thickness L{sub R}, the amplitudes of counterpropagating modes in the slab obey a conditionmore » implying that both have the same modulus and their phases match a condition related to L{sub R} and the bulk wave vectors. When this condition is met, the electric field profile inside the slab is a superposition of standing waves with odd and even symmetries, and the reflection and transmission coefficients can reach great values and become infinite at exact resonance. Numerical simulations of the optical response are shown for a sinusoidal {epsilon}(t) with either moderate or strong modulation. As expected, as the modulation strength increases, higher-order harmonics {omega}-n{Omega} (n=0,{+-}1,{+-}2,...) become more noticeable, and short-wavelength bulk modes contribute significantly. However, we found that, regardless of the excitation frequency {omega}=({Omega}/2)(2l+1), the dominant spectral component of the generated fields is {Omega}/2. Also, as the excitation frequency increases, the parity of the standing waves is conserved.« less

Dietary optimisation with omega-3 and omega-6 fatty acids for 12-23-month-old overweight and obese children in urban Jakarta.

PubMed

Cahyaningrum, Fitrianna; Permadhi, Inge; Ansari, Muhammad Ridwan; Prafiantini, Erfi; Rachman, Purnawati Hustina; Agustina, Rina

2016-12-01

Diets with a specific omega-6/omega-3 fatty acid ratio have been reported to have favourable effects in controlling obesity in adults. However, development a local-based diet by considering the ratio of these fatty acids for improving the nutritional status of overweight and obese children is lacking. Therefore, using linear programming, we developed an affordable optimised diet focusing on the ratio of omega- 6/omega-3 fatty acid intake for obese children aged 12-23 months. A crosssectional study was conducted in two subdistricts of East Jakarta involving 42 normal-weight and 29 overweight and obese children, grouped on the basis of their body mass index for-age Z scores and selected through multistage random sampling. A 24-h recall was performed for 3-nonconsecutive days to assess the children's dietary intake levels and food patterns. We conducted group and structured interviews as well as market surveys to identify food availability, accessibility and affordability. Three types of affordable optimised 7-day diet meal plans were developed on the basis of breastfeeding status. The optimised diet plan fulfilled energy and macronutrient intake requirements within the acceptable macronutrient distribution range. The omega-6/omega-3 fatty acid ratio in the children was between 4 and 10. Moreover, the micronutrient intake level was within the range of the recommended daily allowance or estimated average recommendation and tolerable upper intake level. The optimisation model used in this study provides a mathematical solution for economical diet meal plans that approximate the nutrient requirements for overweight and obese children.

Cardiac function in children with premature ventricular contractions: the effect of omega-3 polyunsaturated fatty acid supplementation.

PubMed

Oner, Taliha; Ozdemir, Rahmi; Doksöz, Onder; Genc, Dildar B; Guven, Baris; Demirpence, Savas; Yilmazer, Murat M; Yozgat, Yilmaz; Mese, Timur; Tavli, Vedide

2018-07-01

Premature ventricular contractions are accepted as benign in structurally normal hearts. However, reversible cardiomyopathy can sometimes develop. Omega-3 polyunsaturated fatty acids have anti-arrhythmic properties in animals and humans.AimWe evaluated left ventricular function in children with premature ventricular contractions with normal cardiac anatomy and assessed the impact of omega-3 fatty acid supplementation on left ventricular function in a prospective trial. A total of 25 patients with premature ventricular contraction, with more than 2% premature ventricular contractions on 24-hour Holter electrocardiography, and 30 healthy patients were included into study. All patients underwent electrocardiography, left ventricular M-mode echocardiography, and myocardial performance index testing. Patients with premature ventricular contraction were given omega-3 fatty acids at a dose of 1 g/day for 3 months, and control echocardiography and 24-hour Holter electrocardiography were performed. Neither placebo nor omega-3 fatty acids were given to the control group. Compared with the values of the control group, the patients with premature ventricular contraction had significantly lower fractional shortening. The myocardial performance index decreased markedly in the patient groups. The mean heart rate and mean premature ventricular contraction percentage of Group 2 significantly decreased in comparison with their baseline values after the omega-3 supplementation. In conclusion, premature ventricular contractions can lead to systolic cardiac dysfunction in children. Omega-3 supplementation may improve cardiac function in children with premature ventricular contractions. This is the first study conducted in children to investigate the possible role of omega-3 fatty acid supplementation on treatment of premature ventricular contractions.

Association of Omega-3 Fatty Acid and Epileptic Seizure in Epileptic Patients: A Systematic Review.

PubMed

Pourmasoumi, Makan; Vosoughi, Nooshin; Derakhshandeh-Rishehri, Seyedeh-Masoumeh; Assarroudi, Mostafa; Heidari-Beni, Motahar

2018-01-01

The evidence on the association between omega-3 consumption and epileptic seizure is inconsistent. Therefore, we have conducted this systematic review to clarify the possible relationship. Original articles were searched in electronic databases (PubMed, Scopus, Google Scholar, Cochrane, and Ovid) and by reviewing the reference lists of retrieved articles. The main evaluated outcome was the epileptic seizures. We included the English language studies that reported the original data on the effect of omega-3 on epileptic human patients. We included the nine articles with 230 patients in the present systematic review. The mean ± standard deviation age of them was about 31.01 ± 14.99 years. The average of study duration was 22 ± 15.27 weeks. Omega-3 fatty acid supplements were defined as the sum of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) (1100 mg/d); as the sum of EPA, DHA, and alpha-linolenic acid (5 g/d); and as the sum of EPA alone (565 mg/d) in different studies. Among the nine studies, four studies reported a significant positive association between omega-3 fatty acids and epileptic seizures. However, power and quality of these studies are low, and we cannot consider the beneficial effect of omega-3 on seizures. In addition, five studies did not reveal any significant effect. Majority of the included studies did not show a significant association between omega-3 and epileptic seizure in epileptic patients, but further studies are necessary. It is controversial whether omega-3 fatty acids can produce positive effects on epileptic patients or not.

Fishy business: effect of omega-3 fatty acids on zinc transporters and free zinc availability in human neuronal cells.

PubMed

De Mel, Damitha; Suphioglu, Cenk

2014-08-15

Omega-3 (ω-3) fatty acids are one of the two main families of long chain polyunsaturated fatty acids (PUFA). The main omega-3 fatty acids in the mammalian body are α-linolenic acid (ALA), docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA). Central nervous tissues of vertebrates are characterized by a high concentration of omega-3 fatty acids. Moreover, in the human brain, DHA is considered as the main structural omega-3 fatty acid, which comprises about 40% of the PUFAs in total. DHA deficiency may be the cause of many disorders such as depression, inability to concentrate, excessive mood swings, anxiety, cardiovascular disease, type 2 diabetes, dry skin and so on. On the other hand, zinc is the most abundant trace metal in the human brain. There are many scientific studies linking zinc, especially excess amounts of free zinc, to cellular death. Neurodegenerative diseases, such as Alzheimer's disease, are characterized by altered zinc metabolism. Both animal model studies and human cell culture studies have shown a possible link between omega-3 fatty acids, zinc transporter levels and free zinc availability at cellular levels. Many other studies have also suggested a possible omega-3 and zinc effect on neurodegeneration and cellular death. Therefore, in this review, we will examine the effect of omega-3 fatty acids on zinc transporters and the importance of free zinc for human neuronal cells. Moreover, we will evaluate the collective understanding of mechanism(s) for the interaction of these elements in neuronal research and their significance for the diagnosis and treatment of neurodegeneration.

Omega-3 fatty acids: new insights into the pharmacology and biology of docosahexaenoic acid, docosapentaenoic acid, and eicosapentaenoic acid.

PubMed

Davidson, Michael H

2013-12-01

Fish oil contains a complex mixture of omega-3 fatty acids, which are predominantly eicosapentaenoic acid (EPA), docosapentaenoic acid, and docosahexaenoic acid (DHA). Each of these omega-3 fatty acids has distinct biological effects that may have variable clinical effects. In addition, plasma levels of omega-3 fatty acids are affected not only by dietary intake, but also by the polymorphisms of coding genes fatty acid desaturase 1-3 for the desaturase enzymes that convert short-chain polyunsaturated fatty acids to long-chain polyunsaturated fatty acids. The clinical significance of this new understanding regarding the complexity of omega-3 fatty acid biology is the purpose of this review. FADS polymorphisms that result in either lower levels of long-chain omega-3 fatty acids or higher levels of long-chain omega-6 polyunsaturated fatty acids, such as arachidonic acid, are associated with dyslipidemia and other cardiovascular risk factors. EPA and DHA have differences in their effects on lipoprotein metabolism, in which EPA, with a more potent peroxisome proliferator-activated receptor-alpha effect, decreases hepatic lipogenesis, whereas DHA not only enhances VLDL lipolysis, resulting in greater conversion to LDL, but also increases HDL cholesterol and larger, more buoyant LDL particles. Overall, these results emphasize that blood concentrations of individual long-chain polyunsaturated fatty acids, which reflect both dietary intake and metabolic influences, may have independent, but also complementary- biological effects and reinforce the need to potentially provide a complex mixture of omega-3 fatty acids to maximize cardiovascular risk reduction.

EFQPSK Versus CERN: A Comparative Study

NASA Technical Reports Server (NTRS)

Borah, Deva K.; Horan, Stephen

2001-01-01

This report presents a comparative study on Enhanced Feher's Quadrature Phase Shift Keying (EFQPSK) and Constrained Envelope Root Nyquist (CERN) techniques. These two techniques have been developed in recent times to provide high spectral and power efficiencies under nonlinear amplifier environment. The purpose of this study is to gain insights into these techniques and to help system planners and designers with an appropriate set of guidelines for using these techniques. The comparative study presented in this report relies on effective simulation models and procedures. Therefore, a significant part of this report is devoted to understanding the mathematical and simulation models of the techniques and their set-up procedures. In particular, mathematical models of EFQPSK and CERN, effects of the sampling rate in discrete time signal representation, and modeling of nonlinear amplifiers and predistorters have been considered in detail. The results of this study show that both EFQPSK and CERN signals provide spectrally efficient communications compared to filtered conventional linear modulation techniques when a nonlinear power amplifier is used. However, there are important differences. The spectral efficiency of CERN signals, with a small amount of input backoff, is significantly better than that of EFQPSK signals if the nonlinear amplifier is an ideal clipper. However, to achieve such spectral efficiencies with a practical nonlinear amplifier, CERN processing requires a predistorter which effectively translates the amplifier's characteristics close to those of an ideal clipper. Thus, the spectral performance of CERN signals strongly depends on the predistorter. EFQPSK signals, on the other hand, do not need such predistorters since their spectra are almost unaffected by the nonlinear amplifier, Ibis report discusses several receiver structures for EFQPSK signals. It is observed that optimal receiver structures can be realized for both coded and uncoded EFQPSK signals with not too much increase in computational complexity. When a nonlinear amplifier is used, the bit error rate (BER) performance of the CERN signals with a matched filter receiver is found to be more than one decibel (dB) worse compared to the bit error performance of EFQPSK signals. Although channel coding is found to provide BER performance improvement for both EFQPSK and CERN signals, the performance of EFQPSK signals remains better than that of CERN. Optimal receiver structures for CERN signals with nonlinear equalization is left as a possible future work. Based on the numerical results, it is concluded that, in nonlinear channels, CERN processing leads towards better bandwidth efficiency with a compromise in power efficiency. Hence for bandwidth efficient communications needs, CERN is a good solution provided effective adaptive predistorters can be realized. On the other hand, EFQPSK signals provide a good power efficient solution with a compromise in band width efficiency.

Dried blood spot omega-3 and omega-6 long chain polyunsaturated fatty acid levels in 7-9 year old Zimbabwean children: a cross sectional study.

PubMed

Mashavave, Grace; Kuona, Patience; Tinago, Willard; Stray-Pedersen, Babill; Munjoma, Marshall; Musarurwa, Cuthbert

2016-01-01

Omega-3 long chain-polyunsaturated fatty acids (LC-PUFAs)-docosahexaenoic acid (DHA), docosapentaenoic acid (DPA) and eicosapentaenoic acid (EPA)- and omega-6 LC-PUFA arachidonic acid (ARA), are essential for optimum physical and mental development in children. Prior to this study, the blood omega-3 LC-PUFA levels were unknown in Zimbabwean children, particularly in those aged 7-9 years, despite the documented benefits of LC-PUFAs. Documentation of the LC-PUFA levels in this age group would help determine whether interventions, such as fortification, are necessary. This study aimed to determine dried whole blood spot omega-3 and omega-6 LC-PUFA levels and LC-PUFA reference intervals among a selected group of Zimbabwean children aged 7-9 years old. We conducted a cross sectional study from September 2011 to August 2012 on a cohort of peri-urban, Zimbabwean children aged 7-9 years. The children were born to mothers enrolled at late pregnancy into an HIV prevention program between 2002 and 2004. Dried whole blood spots were sampled on butylated hydroxytoluene antioxidant impregnated filter papers and dried. LC-PUFAs were quantified using gas liquid chromatography. Differences in LC-PUFAs between groups were compared using the Kruskal Wallis test and reference intervals determined using non-parametric statistical methods. LC-PUFAs levels were determined in 297 Zimbabwean children of whom 170 (57.2 %) were girls. The study determined that LC-PUFAs (wt/wt) ranges were EPA 0.06-0.55 %, DPA 0.38-1.98 %, DHA 1.13-3.52 %, ARA 5.58-14.64 % and ARA: EPA ratio 15.47-1633.33. Sixteen participants had omega-3 LC-PUFAs levels below the determined reference intervals, while 18 had higher omega-6 LC-PUFAs. The study did not show gender differences in omega-3 and omega-6 LC-PUFAs levels (all p > 0.05). EPA was significantly higher in the 8 year age group compared to those aged 7 and 9 years (median; 0.20 vs 0.17 vs 0.18, respectively, p = 0.049). ARA: EPA ratio was significantly higher in the 7 year age group compared to those aged 8 and 9 years (median; 64.38 vs 56.43 vs 55.87 respectively, p = 0.014). In this cohort of children, lower EPA levels and higher ARA: EPA ratios were observed compared to those reported in apparently healthy children elsewhere. The high ARA: EPA ratios might increase the vulnerability of these children to inflammatory pathologies. Identification and incorporation into diet of locally produced foodstuffs rich in omega-3 LC-PUFAs is recommended as well as advocating for dietary supplementation with omega-3 fish oils and algae based oils.

Omega-3 fatty acids for cystic fibrosis.

PubMed

Oliver, Colleen; Watson, Helen

2016-01-05

Studies suggest that a diet rich in omega-3 essential fatty acids may have beneficial anti-inflammatory effects for chronic conditions such as cystic fibrosis. This is an updated version of a previously published review. To determine whether there is evidence that omega-3 polyunsaturated fatty acid supplementation reduces morbidity and mortality and to identify any adverse events associated with supplementation. We searched the Cochrane Cystic Fibrosis and Genetic Disorders Group's Trials Register comprising references identified from comprehensive electronic database searches and handsearches of relevant journals and abstract books of conference proceedings. Authors and persons interested in the subject of the review were contacted.Date of last search: 13 August 2013. Randomised controlled trials in people with cystic fibrosis comparing omega-3 fatty acid supplements with placebo. Two authors independently selected studies for inclusion, extracted data and assessed the risk of bias of the studies. The searches identified 15 studies; four studies with 91 participants (children and adults) were included; duration of studies ranged from six weeks to six months. Two studies were judged to be at low risk of bias based on adequate randomisation but this was unclear in the other two studies. Three of the studies adequately blinded patients, however, the risk of bias was unclear in all studies with regards to allocation concealment and selective reporting.Two studies compared omega-3 fatty acids to olive oil for six weeks. One study compared a liquid dietary supplement containing omega-3 fatty acids to one without for six months. One study compared omega-3 fatty acids and omega-6 fatty acids to a control (capsules with customised fatty acid blends) for three months. Only one short-term study (19 participants) comparing omega-3 to placebo reported a significant improvement in lung function and Shwachman score and a reduction in sputum volume in the omega-3 group. Another study (43 participants) demonstrated a significant increase in serum phospholipid essential fatty acid content and a significant drop in the n-6/n-3 fatty acid ratio following omega-3 fatty acid supplementation compared to control. The longer-term study (17 participants) demonstrated a significant increase in essential fatty acid content in neutrophil membranes and a significant decrease in the leukotriene B4 to leukotriene B5 ratio in participants taking omega-3 supplements compared to placebo. This review found that regular omega-3 supplements may provide some benefits for people with cystic fibrosis with relatively few adverse effects, although evidence is insufficient to draw firm conclusions or recommend routine use of these supplements in people with cystic fibrosis. This review has highlighted the lack of data for many outcomes meaningful to people with or making treatment decisions about cystic fibrosis. A large, long-term, multicentre, randomised controlled study is needed to determine any significant therapeutic effect and to assess the influence of disease severity, dosage and duration of treatment. Future researchers should note the need for additional pancreatic enzymes.

Sensitivity of postplanning target and OAR coverage estimates to dosimetric margin distribution sampling parameters

DOE Office of Scientific and Technical Information (OSTI.GOV)

Xu Huijun; Gordon, J. James; Siebers, Jeffrey V.

2011-02-15

Purpose: A dosimetric margin (DM) is the margin in a specified direction between a structure and a specified isodose surface, corresponding to a prescription or tolerance dose. The dosimetric margin distribution (DMD) is the distribution of DMs over all directions. Given a geometric uncertainty model, representing inter- or intrafraction setup uncertainties or internal organ motion, the DMD can be used to calculate coverage Q, which is the probability that a realized target or organ-at-risk (OAR) dose metric D{sub v} exceeds the corresponding prescription or tolerance dose. Postplanning coverage evaluation quantifies the percentage of uncertainties for which target and OAR structuresmore » meet their intended dose constraints. The goal of the present work is to evaluate coverage probabilities for 28 prostate treatment plans to determine DMD sampling parameters that ensure adequate accuracy for postplanning coverage estimates. Methods: Normally distributed interfraction setup uncertainties were applied to 28 plans for localized prostate cancer, with prescribed dose of 79.2 Gy and 10 mm clinical target volume to planning target volume (CTV-to-PTV) margins. Using angular or isotropic sampling techniques, dosimetric margins were determined for the CTV, bladder and rectum, assuming shift invariance of the dose distribution. For angular sampling, DMDs were sampled at fixed angular intervals {omega} (e.g., {omega}=1 deg., 2 deg., 5 deg., 10 deg., 20 deg.). Isotropic samples were uniformly distributed on the unit sphere resulting in variable angular increments, but were calculated for the same number of sampling directions as angular DMDs, and accordingly characterized by the effective angular increment {omega}{sub eff}. In each direction, the DM was calculated by moving the structure in radial steps of size {delta}(=0.1,0.2,0.5,1 mm) until the specified isodose was crossed. Coverage estimation accuracy {Delta}Q was quantified as a function of the sampling parameters {omega} or {omega}{sub eff} and {delta}. Results: The accuracy of coverage estimates depends on angular and radial DMD sampling parameters {omega} or {omega}{sub eff} and {delta}, as well as the employed sampling technique. Target |{Delta}Q|<1% and OAR |{Delta}Q|<3% can be achieved with sampling parameters {omega} or {omega}{sub eff}=20 deg., {delta}=1 mm. Better accuracy (target |{Delta}Q|<0.5% and OAR |{Delta}Q|<{approx}1%) can be achieved with {omega} or {omega}{sub eff}=10 deg., {delta}=0.5 mm. As the number of sampling points decreases, the isotropic sampling method maintains better accuracy than fixed angular sampling. Conclusions: Coverage estimates for post-planning evaluation are essential since coverage values of targets and OARs often differ from the values implied by the static margin-based plans. Finer sampling of the DMD enables more accurate assessment of the effect of geometric uncertainties on coverage estimates prior to treatment. DMD sampling with {omega} or {omega}{sub eff}=10 deg. and {delta}=0.5 mm should be adequate for planning purposes.« less

21 CFR 175.105 - Adhesives.

Code of Federal Regulations, 2013 CFR

2013-04-01

...) content averages 9 or 30 moles endo-cis-5-Norbornene-2,3-dicarboxylic anhydride α-cis-9-Octadecenyl-omega...) Potassium tripolyphosphate α, α′, α″-1,2,3-Propanetriyltris [omega-(2,3-epoxypropoxy) poly (oxypropylene... (3,5-di-tert-butyl-4-hydroxy-hydro-cinnamate)] methane a[p-(1,1,3,3-Tetramethylbutyl) phenyl]-omega...

21 CFR 175.105 - Adhesives.

Code of Federal Regulations, 2012 CFR

2012-04-01

...) content averages 9 or 30 moles endo-cis-5-Norbornene-2,3-dicarboxylic anhydride α-cis-9-Octadecenyl-omega...) Potassium tripolyphosphate α, α′, α″-1,2,3-Propanetriyltris [omega-(2,3-epoxypropoxy) poly (oxypropylene... (3,5-di-tert-butyl-4-hydroxy-hydro-cinnamate)] methane a[p-(1,1,3,3-Tetramethylbutyl) phenyl]-omega...

76 FR 6487 - National Center for Complementary and Alternative Medicine; Announcement of Workshop on...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-04

... Mechanistic and Translational Research on Omega-3 Fatty Acids and Their Metabolites ACTION: Notice. SUMMARY... Research on Omega-3 Fatty Acids and their Metabolites. The purpose of this workshop is to bring together... the underlying mechanisms of Omega-3 fatty acids and their metabolites. The goal is to identify...

21 CFR 175.105 - Adhesives.

Code of Federal Regulations, 2014 CFR

2014-04-01

...) content averages 9 or 30 moles endo-cis-5-Norbornene-2,3-dicarboxylic anhydride α-cis-9-Octadecenyl-omega...) Potassium tripolyphosphate α, α′, α″-1,2,3-Propanetriyltris [omega-(2,3-epoxypropoxy) poly (oxypropylene... (3,5-di-tert-butyl-4-hydroxy-hydro-cinnamate)] methane a[p-(1,1,3,3-Tetramethylbutyl) phenyl]-omega...

Effects of supplementation with omega-3 on insulin sensitivity and non-esterified free fatty acid (NEFA) in type 2 diabetic patients.

PubMed

Farsi, Payam Farahbakhsh; Djazayery, Abolghassem; Eshraghian, Mohammad Reza; Koohdani, Fariba; Saboor-Yaraghi, Ali Akbar; Derakhshanian, Hoda; Zarei, Mahnaz; Javanbakht, Mohammad Hassan; Djalali, Mahmoud

2014-06-01

The aim of this study was to determine the role of omega-3 supplementation on NEFA concentration, insulin sensitivity and resistance, and glucose and lipid metabolism in type 2 diabetic patients. Forty-four type 2 diabetic patients were randomly recruited into two groups. Group A received 4 g/day omega-3 soft gels, and group B received a placebo for 10 wks. Blood samples were collected after 12-h fast. Physical activity records, three-day food records, and anthropometric measurements were obtained from all participants at the beginning and end of the study. Omega-3 supplementation caused a significant reduction in NEFA in the intervention group compared with the placebo group (P = 0.009). Additionally, the administration of omega-3 resulted in significantly greater changes (Diff) for the intervention group in various parameters, such as insulin and Quicki indices compared with the placebo group (P < 0.05). Omega-3 fatty acid supplementation in type 2 diabetic patients improved insulin sensitivity, probably due to the decrease in NEFA concentrations.

Fatty acid profiles among the Inuit of Nunavik: current status and temporal change.

PubMed

Proust, Françoise; Lucas, Michel; Dewailly, Eric

2014-05-01

The Inuit undergo substantial changes in their lifestyle, but few data exist on how these changes occur in biomarkers, such as polyunsaturated fatty acids (PUFAs). Here, we report data from a cross-sectional survey conducted in 2004 among 861 representative Nunavik Inuit adults, in whom FAs were measured in red blood cells (RBCs). FAs were also measured in plasma phospholipids (n=452) to assess temporal trend by comparing plasma PUFAs measured in 1992. Food intakes were estimated using a validated food frequency questionnaire. In 2004, marine food intake was 84±4g/d (±SEM). Adjusted-mean of RBC omega-3 was significantly higher, and omega-6 lower, in older age groups (Ptrend<0.001). In 2004, plasma omega-3 was 25% lower, while omega-6 was 9% higher, compared to 1992. Our study revealed that Nunavik Inuit adults still have high RBC omega-3, but show signs of nutritional transition - as indicated by lower omega-3 and higher trans-fats in RBCs of young compared to older. Copyright © 2014 Elsevier Ltd. All rights reserved.

Effect of omega-3 fatty acids on the modification of erythrocyte membrane fatty acid content including oleic acid in peritoneal dialysis patients.

PubMed

An, W S; Lee, S M; Son, Y K; Kim, S E; Kim, K H; Han, J Y; Bae, H R; Park, Y

2012-01-01

Erythrocyte membrane fatty acids (FA), such as oleic acid, are related to acute coronary syndrome. There is no report about the effect of omega-3 FA on oleic acid in peritoneal dialysis (PD) patients. We hypothesized that omega-3 FA can modify erythrocyte membrane FA, including oleic acid, in PD patients. In a double-blind, randomized, placebo-controlled study, 18 patients who were treated with PD for at least 6 months were randomized to treatment for 12 weeks with omega-3 FA or placebo. Erythrocyte membrane FA content was measured by gas chromatography at baseline and after 12 weeks. The erythrocyte membrane content of eicosapentaenoic acid and docosahexaenoic acid was significantly increased and saturated FA and oleic acid were significantly decreased in the omega-3 FA supplementation group after 12 weeks compared to baseline. In conclusion, erythrocyte membrane FA content, including oleic acid, was significantly modified by omega-3 FA supplementation for 12 weeks in PD patients. Copyright © 2011 Elsevier Ltd. All rights reserved.

The effects of diazepam and zolpidem on cocaine- and amphetamine-induced place preference.

PubMed

Meririnne, E; Kankaanpää, A; Lillsunde, P; Seppälä, T

1999-01-01

Drugs such as benzodiazepines, which enhance the effects of inhibitory neurotransmitter gamma-amino butyric acid (GABA), are known to modulate the mesocorticolimbic dopaminergic system, which is considered to mediate the rewarding effects of psychostimulants. The effects of diazepam, a benzodiazepine that binds unspecifically to omega 1- (omega1-) and omega2-receptors, and zolpidem, a nonbenzodiazepine drug that binds preferentially to omega1-receptors, on cocaine- and amphetamine-induced place preference were evaluated in Wistar rats. In tests using the counterbalanced method, neither diazepam (0.2, 1, and 5 mg/kg) nor zolpidem (2.5, 5, and 10 mg/kg) alone induced place preference or place aversion. Diazepam pretreatment prevented both cocaine- and amphetamine-induced (15 and 9 mg/kg, respectively) place preference; however, at doses that were earlier shown to cause sedation and amnesia, zolpidem failed to prevent either cocaine- or amphetamine-induced place preference. These results suggest that diazepam interferes with the rewarding properties of the psychostimulants, whereas zolpidem is less effective in this respect, possibly due to differential distribution of omega1- and omega2-receptors in the brain.

Sharing scientific discovery globally: toward a CERN virtual visit service

NASA Astrophysics Data System (ADS)

Goldfarb, S.; Hatzifotiadou, D.; Lapka, M.; Papanestis, A.

2017-10-01

The installation of virtual visit services by the LHC collaborations began shortly after the first high-energy collisions were provided by the CERN accelerator in 2010. The experiments: ATLAS [1], CMS [2], LHCb [3], and ALICE [4] have all joined in this popular and effective method to bring the excitement of scientific exploration and discovery into classrooms and other public venues around the world. Their programmes, which use a combination of video conference, webcast, and video recording to communicate with remote audiences have already reached tens of thousands of viewers, and the demand only continues to grow. Other venues, such as the CERN Control Centre, are also considering similar permanent installations. We present a summary of the development of the various systems in use around CERN today, including the technology deployed and a variety of use cases. We then lay down the arguments for the creation of a CERN-wide service that would support these programmes in a more coherent and effective manner. Potential services include a central booking system and operational management similar to what is currently provided for the common CERN video conference facilities. Certain choices in technology could be made to support programmes based on popular tools including (but not limited to) Skype™ [5], Google Hangouts [6], Facebook Live [7], and Periscope [8]. Successful implementation of the project, which relies on close partnership between the experiments, CERN IT CDA [9], and CERN IR ECO [10], has the potential to reach an even larger, global audience, more effectively than ever before.

A case series on the potential effect of omega-3-fatty acid supplementation on 24-h heart rate variability and its circadian variation in children with attention deficit (hyperactivity) disorder.

PubMed

Buchhorn, Reiner; Koenig, Julian; Jarczok, Marc N; Eichholz, Hanna; Willaschek, Christian; Thayer, Julian F; Kaess, Michael

2018-06-01

Attention deficit disorder with and without hyperactivity (ADHD) in children is associated with decreased 24-h heart rate variability (HRV). Previous research has shown that supplementation of omega-3-fatty acid increases HRV. Here, we aimed to investigate whether the supplementation of omega-3-fatty acids would increase 24-h HRV in an uncontrolled case series of children with ADHD. HRV was recorded in 18 children and adolescents (age 13.35 ± 2.8 years) before and after omega-3 supplementation. Preliminary results indicate that omega-3 supplementation in children with AD(H)D may reduce mean heart rate and increase its variability. Future studies would do well to implement randomized, placebo-controlled designs with greater methodological rigor.

Beneficial effects of omega-3 fatty acids and vitamin B12 supplementation on brain docosahexaenoic acid, brain derived neurotrophic factor, and cognitive performance in the second-generation Wistar rats.

PubMed

Rathod, Richa S; Khaire, Amrita A; Kale, Anvita A; Joshi, Sadhana R

2015-01-01

In vegetarian population, vitamin B12 deficiency coexists with suboptimal levels of omega-3 fatty acids. Studies indicate a need for supplementation/fortification of vitamin B12 and omega-3 fatty acids to reduce the risk of brain disorders. We have described the effects of vitamin B12 and omega-3 fatty acid supplementation on brain development in F1 generation animals. The current study investigates the effects of vitamin B12 and omega-3 fatty acids supplementation on brain function and cognition. Pregnant Wistar rats were assigned the following groups: control, vitamin B12 deficient (BD), vitamin B12 deficient + omega-3 fatty acid (BDO), vitamin B12 supplemented (BS), vitamin B12 supplemented + omega-3 fatty acid (BSO). The same diets were continued for two generations. BDO group showed higher (P < 0.05) levels of BDNF (brain derived neurotrophic factor) and DHA (docosahexaenoic acid) in the cortex and hippocampus as compared with the BD group. The cognitive performance was also normalized in this group. BS showed comparable levels of DHA, BDNF (protein and mRNA), and CREB mRNA (cAMP response element-binding protein) to that of control group while Tropomyosin receptor kinase mRNA levels were higher. The combined vitamin B12 and omega-3 fatty acid supplementation further enhanced the levels of DHA (P < 0.05) and BDNF (P < 0.05) in the hippocampus and CREB mRNA (P < 0.01) in the cortex as compared with BS group. The cognitive performance of these animals was higher (P < 0.05) as compared with BS group. Our data indicates the beneficial effects of vitamin B12 and omega-3 fatty acid supplementation across two generations on brain development and function. © 2015 International Union of Biochemistry and Molecular Biology.

Resonances in the predissociation of the A{sup 2}{Pi}{sub {Omega}} state of MgBr

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sadygov, R.G.; Rostas, J.; Taieb, G.

1997-03-01

Electronic structure methods and nonperturbative resonance theory are applied to study the radiative and radiationless decay mechanisms of the MgBr (A{sup 2}{Pi}{sub {Omega}}) vibrational levels. The X{sup 2}{Sigma}{sup +} and 1,2{sup 2}{Pi}{sub {Omega}} adiabatic electronic states are characterized using {ital ab initio} state-averaged multiconfigurational self-consistent field/second order configuration interaction wave functions. Interstate derivative couplings between the {sup 2}{Pi} states have been calculated and used to construct a rigorous diabatic basis. The nonrelativistic potential energy curves are modified in the first order of degenerate perturbation theory to take account of the spin{endash}orbit interactions treated within Breit{endash}Pauli approximation. All vibrational levels inmore » the A{sup 2}{Pi}{sub {Omega}} manifold are resonances predissociated by the repulsive 2{sup 2}{Pi} state. A recently developed computational approach [S. Han and D. R. Yarkony, Mol. Phys. {bold 88}, 53 (1996)] based on a Feshbach formalism is employed to determine energies, linewidths, and radiative and radiationless decay rates in a coupled diabatic states basis within a Hund`s case (a) approximation. Large nonadiabatic interactions cause significant energy shifts in the resonances levels. It is shown that a pronounced {Omega}-dependence in the radiationless decay rates results from the large fine structure splitting in the 2{sup 2}{Pi}{sub {Omega}} diabatic state which corresponds to Mg({sup 1}S)Br({sup 2}P). Comparisons with absorption and fluorescence spectra reveal important insights into A{sup 2}{Pi}{sub {Omega}} state decay. The spectroscopic constants of the A{sup 2}{Pi}{sub {Omega}}, {Omega}=3/2 and 1/2 states and the A{sup 2}{Pi}{sub 3/2} state predissociation are well described in a Hund`s case (a) approximation. However it is found that the A{sup 2}{Pi}{sub 1/2} state predissociation is significantly underestimated in this limit. (Abstract Truncated)« less

Effect of Omega-3 Polyunsaturated Fatty Acids Supplementation on Body Composition and Circulating Levels of Follistatin-Like 1 in Males With Coronary Artery Disease: A Randomized Double-Blind Clinical Trial.

PubMed

Jafari Salim, Shirin; Alizadeh, Shahab; Djalali, Mahmoud; Nematipour, Ebrahim; Hassan Javanbakht, Mohammad

2017-11-01

Adipokines are mediators of body composition and are involved in obesity-related complications such as cardiovascular disease. Omega-3 supplementation has not been studied in the setting of body composition and follistatin-like 1 (FSTL1) levels in patients with coronary artery disease (CAD). This study aimed to investigate the effect of omega-3 polyunsaturated fatty acid (ω-3 PUFA) supplementation on body composition indices and serum levels of FSTL1 in CAD patients. A total of 42 male (aged 45-65 years) subjects with angiographically confirmed CAD were included in this randomized, double-blind, placebo-controlled trial study. The subjects were randomly divided into omega-3 and placebo groups. During the 8-week intervention, the omega-3 group received 1,200 mg of omega-3 daily, while the placebo group received paraffin. Before and after the study, anthropometric measurements and body composition components were taken; serum FSTL1 levels were assessed by an enzyme-linked immunosorbent assay (ELISA) kit. In the omega-3 group, a significant 27.6% increase in serum FSTL1 was seen after 8 weeks of intervention ( p = .001), but no significant difference in posttreatment levels of FSTL1 was observed between the two groups ( p > .05). At the end of the study, a significant decrease in low-density lipoprotein cholesterol (LDL-C; 94.29 ± 22.04 vs. 112.24 ± 24.5; p = .01) and high-sensitivity C-reactive protein (hs-CRP; 1.92 ± 0.79 vs. 3.19 ± 2.51; p = .03) concentration was detected between the two groups. Changes in fasting blood sugar, fasting insulin, body composition, and anthropometric parameters were not significant within and between the groups. Oral omega-3 might increase FSTL1 and decrease LDL-C and hs-CRP concentrations in CAD patients. However, omega-3 supplementation did not have any effect on FSTL1 levels between the groups.

Replication of a Gene-Diet Interaction at CD36, NOS3 and PPARG in Response to Omega-3 Fatty Acid Supplements on Blood Lipids: A Double-Blind Randomized Controlled Trial.

PubMed

Zheng, Ju-Sheng; Chen, Jiewen; Wang, Ling; Yang, Hong; Fang, Ling; Yu, Ying; Yuan, Liping; Feng, Jueping; Li, Kelei; Tang, Jun; Lin, Mei; Lai, Chao-Qiang; Li, Duo

2018-05-01

Modulation of genetic variants on the effect of omega-3 fatty acid supplements on blood lipids is still unclear. In a double-blind randomized controlled trial, 150 patients with type 2 diabetes (T2D) were randomized into omega-3 fatty acid group (n = 56 for fish oil and 44 for flaxseed oil) and control group (n = 50) for 180 days. All patients were genotyped for genetic variants at CD36 (rs1527483), NOS3 (rs1799983) and PPARG (rs1801282). Linear regression was used to examine the interaction between omega-3 fatty acid intervention and CD36, NOS3 or PPARG variants for blood lipids. Significant interaction with omega-3 fatty acid supplements was observed for CD36 on triglycerides (p-interaction = 0.042) and PPAGR on low-density lipoprotein-cholesterol (p-interaction = 0.02). We also found a significant interaction between change in erythrocyte phospholipid omega-3 fatty acid composition and NOS3 genotype on triglycerides (p-interaction = 0.042), total cholesterol (p-interaction = 0.013) and ratio of total cholesterol to high-density lipoprotein cholesterol (p-interaction = 0.015). The T2D patients of CD36-G allele, PPARG-G allele and NOS3-A allele tended to respond better to omega-3 fatty acids in improving lipid profiles. The interaction results of the omega-3 fatty acid group were mainly attributed to the fish oil supplements. This study suggests that T2D patients with different genotypes at CD36, NOS3 and PPARG respond differentially to intervention of omega-3 supplements in blood lipid profiles. Copyright © 2018 The Authors. Published by Elsevier B.V. All rights reserved.

Monitoring the efficacy of omega-3 supplementation on liver steatosis and carotid intima-media thickness: a pilot study.

PubMed

Lacasse, M-C; Tang, A; Dubois, J; Alvarez, F; Spahis, S; Chagnon, M; Deschênes, S; Levy, E

2017-06-01

To determine the effects of omega-3 supplementation on liver fat and carotid intima-media thickness (IMT) and to assess accuracy of ultrasound (US) for grading liver steatosis. In this one-way crossover pilot study, we assigned children with obesity and liver steatosis to receive 1.2 g daily of omega-3 supplementation vs. inactive sunflower oil for 24 or 12 weeks. Liver fat content was assessed by magnetic resonance spectroscopy (MRS), magnetic resonance imaging (MRI) and US, and common carotid IMT by US. Statistical analysis included Chi-square, Student's t -tests, ANOVA tests and receiver operating characteristic (ROC) curves. Omega-3 supplementation was associated with a trend towards decrease in MRS-determined liver fat fraction (0.7% and 2.1% decrease in the 24-week and 12-week omega-3 group, respectively) compared with the sunflower oil group (1.0% increase). These changes were not significant, whether assessed by MRS ( P  = 0.508), MRI ( P  = 0.508) or US ( P  = 0.678). Using US, the area under the ROC curves were 0.964, 0.817 and 0.783 for distinguishing inferred steatosis grades 0 vs. 1-2-3, 0-1 vs. 2-3 and 0-1-2 vs. 3, respectively, indicating good accuracy of US-based fat grading. Omega-3 supplementation was associated with a decrease in US-determined IMT (0.05-mm decrease in the 24-week omega-3 group. A 0.015-mm increase was found in the 12-week omega-3 group, and a 0.007-mm decrease in the sunflower oil group ( P  = 0.003). Omega-3 supplementation had no significant effect on liver fat fraction, but led to carotid IMT decrease in children with obesity and liver steatosis.

Impact of Biological Feedback and Incentives on Blood Fatty Acid Concentrations, Including Omega-3 Index, in an Employer-Based Wellness Program.

PubMed

McBurney, Michael I; Bird, Julia K

2017-08-05

Eicosapentaenoic acid (EPA, C20:5n-3) and docosahexaenoic acid (DHA, C22:6n-3) are important fatty acids for the retina and brain. More than 95% of Americans have suboptimal EPA + DHA blood concentrations. This cross-sectional employer-based study assessed whole blood fatty acid levels of volunteers participating in an onsite wellness biometric screening program and was designed to determine if an incentive, a $5 coupon for a 90-day supply of fish oil supplement typically costing $18-30, stimulated incremental dietary behavior change relative to nutritional status assessment alone to increase EPA + DHA concentrations. Volunteers completed a dietary survey and finger stick blood samples were collected to be analyzed for fatty acid composition. In addition, 636 individuals participated in the initial onsite biometric screening. Three months later, and without prior knowledge, all employees were invited to a second screening. At the second screening, 198 employees volunteered for the first time and 149 employees had a second test (17.9%). At baseline, the average age ( n = 834) was 45 year and omega-3 index was 5.0% with 41% female. EPA + DHA concentration, i.e., omega-3 index, was significantly lower in men (4.8%) than women (5.2%), as were DHA and linoleic acid (LA) concentrations ( p < 0.05). Baseline omega-3 index was positively and linearly associated with omega-3 intake. Only 4% of volunteers had an omega-3 index >8% on initial screening. Among the 149 individuals with two measurements, omega-3 intake from supplements, but not food, increased significantly from 258 to 445 mg/d ( p < 0.01) at the second test as did the omega-3 index (+0.21, p < 0.02). In this employed population, only 1% redeemed a coupon for an omega-3 supplement.

Red blood cell oleic acid levels reflect olive oil intake while omega-3 levels reflect fish intake and the use of omega-3 acid ethyl esters: The Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico-Heart Failure trial.

PubMed

Harris, William S; Masson, Serge; Barlera, Simona; Milani, Valentina; Pileggi, Silvana; Franzosi, Maria Grazia; Marchioli, Roberto; Tognoni, Gianni; Tavazzi, Luigi; Latini, Roberto

2016-09-01

The Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico-Heart Failure (GISSI-HF) study reported benefits of n-3 fatty acid (FA) treatment on cardiovascular (CV) events, but the effects of treatment on a putative CV disease risk factor, the red blood cell (RBC) n-3 FA level (the omega-3 index), have not been examined in this context. We hypothesized that treatment with prescription omega-3 acid ethyl esters (O3AEE) would increase the omega-3 index to the proposed cardioprotective value of 8%. RBCs were collected from a subset of patients participating in the GISSI-HF study (n=461 out of 6975 randomized), at baseline and after 3 months of treatment with either an olive oil placebo or O3AEE (1 g/d). RBC FA levels were expressed as a percentage of total FA. Patients also reported their typical olive oil and fish intakes. RBC oleic acid levels were directly correlated with reported frequency of olive oil consumption, and the omega-3 index was correlated with reported fish intake (P for trends <0.001 for both). After treatment, the omega-3 index increased from 4.8±1.7% to 6.7±1.9% but was unchanged in the placebo group (4.7±1.7 to 4.8±1.5%) (P<.0001 for changes between groups). At 3 months, more patients reached the proposed target omega-3 index level of 8%-12% in the treated vs placebo group (22.6% vs. 1.3%, P<.0001), however, what omega-3 index levels were ultimately achieved after four years in this trial are unknown. Copyright © 2016 Elsevier Inc. All rights reserved.

Thermodynamics of the clusterization process of cis isomers of unsaturated fatty acids at the air/water interface.

PubMed

Vysotsky, Yu B; Belyaeva, E A; Fainerman, V B; Vollhardt, D; Aksenenko, E V; Miller, R

2009-04-02

In the framework of the semiempirical PM3 method, the thermodynamic parameters of cis isomers of unsaturated carboxylic acids at the air/water interface are studied. The model systems used are unsaturated cis fatty acid of the composition Delta = 12-15 and omega = 6-11, where Delta and omega refer to the number of carbon atoms between the functional group and double bond, and that between the double bond and methyl group, respectively. For dimers, trimers, and tetramers of the four acid series, the thermodynamic parameters of clusterization are calculated. It is shown that the position of the double bond does not significantly affect the values of thermodynamic parameters of formation and clusterization of carboxylic acids for equal chain lengths (n = Delta + omega). The calculated results show that for cis unsaturated fatty acid with odd Delta values the spontaneous clusterization threshold corresponds to n = 17-18 carbon atoms in the alkyl chain, while for monounsaturated acids with even Delta values this threshold corresponds to n = 18-19 carbon atoms in the alkyl chain. These differences in the clusterization threshold between the acids with even and odd Delta values are attributed to the formation of additional intermolecular hydrogen bonds between the ketonic oxygen atom of one monomer and the hydrogen atom linked to the alpha-carbon atom of the second monomer for the acids with odd Delta values or between the hydroxyl oxygen atom of one monomer and hydrogen atom linked to the alpha-carbon atom of the second monomer for the acids with even Delta values. The results obtained in the study agree satisfactorily with our experimental data for cis unsaturated nervonic (Delta15, omega9) and erucic acids (Delta13, omega9), and published data for some fatty acids, namely cis-16-heptadecenoic (Delta16, omega1), cis-9-hexadecenoic (Delta7, omega9), cis-11-eicosenoic (Delta11, omega9) and cis-9-octadecenoic acid (Delta9, omega9).

Omega 3 Chia seed loading as a means of carbohydrate loading.

PubMed

Illian, Travis G; Casey, Jason C; Bishop, Phillip A

2011-01-01

The purpose of this study was to determine if Omega 3 Chia seed loading is a viable option for enhancing sports performance in events lasting >90 minutes and allow athletes to decrease their dietary intake of sugar while increasing their intake of Omega 3 fatty acids. It has been well documented that a high dietary carbohydrate (CHO) intake for several days before competition is known to increase muscle glycogen stores resulting in performance improvements in events lasting >90 minutes. This study compared performance testing results between 2 different CHO-loading treatments. The traditional CHO-loading treatment served as the control (100% cals from Gatorade). The Omega 3 Chia drink (50% of calories from Greens Plus Omega 3 Chia seeds, 50% Gatorade) served as the Omega 3 Chia loading drink. Both CHO-loading treatments were based on the subject's body weight and were thus isocaloric. Six highly trained male subjects V(O2)max 47.8-84.2 ml · kg(-1); mean (SD) of V(O2)max 70.3 ml · kg(-1) (13.3) performed a 1-hour run at ∼65% of their V(O2)max on a treadmill, followed by a 10k time trial on a track. There were 2 trials in a crossover counterbalanced repeated-measures design with a 2-week washout between testing sessions to allow the participants to recover from the intense exercise and any effects of the treatment. There was no statistical difference (p = 0.83) between Omega 3 Chia loading (mean 10k time = 37 minutes 49 seconds) and CHO loading (mean = 37 minutes 43 seconds). Under our conditions, Omega 3 Chia loading appears a viable option for enhancing performance for endurance events lasting >90 minutes and allows athletes to decrease their dietary intake of sugar while increasing their intake of Omega 3 fatty acids but offered no performance advantages.

The Local Supercluster as a test of cosmological models

NASA Technical Reports Server (NTRS)

Cen, Renyue

1994-01-01

The Local Supercluster kinematic properties (the Local Group infall toward the Virgo Cluster and galaxy density distribution about the Virgo Cluster) in various cosmological models are examined utilizing large-scale N-body (PM) simulations 500(exp 3) cells, 250(exp 3) particles, and box size of 400 h(exp -1) Mpc) and are compared to observations. Five models are investigated: (1) the standard, Cosmic Background Explorer Satellite (COBE)-normalized cold dark matter (CDM) model with omega = 1, h = 0.5, and sigma(sub 8) = 1.05; (2) the standard Hot Dark Matter (HDM) model with omega = 1, h = 0.75, and sigma(sub 8) = 1; (3) the tilted CDM model with omega = 1, h = 0.5, n = 0.7, and sigma(sub 8) = 0.5; (4) a CDM + lambda model with omega = 0.3, lambda = 0.7, h = 2/3, and sigma(sub 8) = 2/3; (5) the PBI model with omega = 0.2, h = 0.8, x = 0.1, m = -0.5, and sigma(sub 8) = 0.9. Comparison of the five models with the presently available observational measurements v(sub LG) = 85 - 305 km/s (with mean of 250 km/s), delta(n(sub g))/(n(sub g)-bar) = 1.40 + or - 0.35) suggests that an open universe with omega approximately 0.5 (with or without lambda) and sigma(sub 8) approximately 0.8 is preferred, with omega = 0.3-1.0 (with or without lambda) and sigma(sub 8) = 0.7-1.0 being the acceptable range. At variance with some previous claims based on either direct N-body or spherical nonlinear approaches, we find that a flat model with sigma(sub 8) approximately 0.7-1.0 seems to be reasonably consistent with observations. However, if one favors the low limit of v(sub LG) = 85 km/s, then an omega approximately 0.2-0.3 universe seems to provide a better fit, and flat (omega = 1) models are ruled out at approximately 95% confidence level. On the other hand, if the high limit of v(sub LG) = 350 km/s is closer to the truth, then it appears that omega approximately 0.7-0.8 is more consistent. This test is insensitive to the shape of the power spectrum, but rather sensitive to the normalization of the perturbation amplitude on the relevant scale (e.g., sigma(sub 8)) and omega. We find that neither linear nor nonlinear relations (with spherical symmetry) are good approximations for the relation between radial peculiar velocity and density perturbation, i.e., nonspherical effects and gravitational tidal field are important. The derived omega using either of the two relations is underestimated. In some cases, this error is as large as a factor of 2-4.

Spin fluctations and heavy fermions in the Kondo lattice

DOE Office of Scientific and Technical Information (OSTI.GOV)

Khaliullin, G.G.

1994-09-01

This paper studies the spectrum of the spin and electronic excitations of the Kondo lattice at low temperatures. To avoid unphysical states, the Mattis {open_quotes}drone{close_quotes}-fermion representation for localized spins is employed. First, the known Fermi liquid properties of a single impurity are examined. The behavior of the correlator between a localized spin and the electron spin density at large distances shows that the effective interaction between electrons on the Fermi level and low-energy localized spin fluctuations scales as {rho}{sup {minus}1}, where {rho} is the band-state density. This fact is developed into a renormalization of the band spectrum in a periodicmore » lattice. If the Ruderman-Kittel-Kasuya-Yosida (RKKY) interaction between localized spins is much smaller than the Kondo fluctuation frequency {omega}{sub k}, the temperature of the crossover to the single-parameter Fermi liquid mode is determined by {omega}{sub k}. When the RKKY interaction becomes of order {omega}{sub k}, there is a new scale {omega}{sub sf}, the energy of the (antiferromagnetic) paramagnon mode, with {omega}{sub sf}{much_lt}{omega}{sub k}. Here the coherent Fermi liquid regime is realized only below a temperature T{sub coh} of order {omega}{sub sf}, while above T{sub coh} quasiparticle damping exhibits a linear temperature dependence. Finally, the nuclear-spin relaxation rate is calculated. 42 refs.« less

The effects of vitamin E and omega-3 PUFAs on endothelial function among adolescents with metabolic syndrome.

PubMed

Ahmadi, Alireza; Gharipour, Mojgan; Arabzadeh, Gholamreza; Moin, Payam; Hashemipour, Mahin; Kelishadi, Roya

2014-01-01

The present study aims to explore the effects of vitamin E and omega-3 on endothelial function indicators among adolescents with metabolic syndrome. In a randomized, double blind, and placebo-controlled trial, 90 young individuals, aged 10 to 18 years, with metabolic syndrome were randomly assigned to receive either vitamin E tablets (400 IU/day) or omega-3 tablets (2.4 gr/day) or placebo. For assessing endothelial functional state, the serum level of vascular endothelial growth factor (VEGF) was measured by ELISA test. The use of omega-3 supplementation for eight weeks led to significant increase in serum HDL level compared with the group treated with vitamin E or placebo group. In this regard, no significant correlations were found between the change in VEGF and baseline levels of other markers including anthropometric indices and serum lipids. Omega-3 could significantly reduce VEGF with the presence of other baseline variables (Beta = -12.55; P = 0.012). The administration of omega-3 can effectively improve endothelial function in adolescents with metabolic syndrome by reducing the level of serum VEGF, as a major index for atherosclerosis progression and endothelial destabilization. Omega-3 can be proposed as a VEGF antagonist for improving endothelial function in metabolic syndrome. The clinical implications of our findings should be assessed in future studies.

Bioavailability of Dietary Omega-3 Fatty Acids Added to a Variety of Sausages in Healthy Individuals

PubMed Central

Köhler, Anton; Heinrich, Johanna; von Schacky, Clemens

2017-01-01

A low Omega-3 Index (eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in erythrocytes) is associated with cardiac, cerebral, and other health issues. Intake of EPA and DHA, but not of alpha-linolenic acid (ALA), increases the Omega-3 Index. We investigated bioavailability, safety, palatability and tolerability of EPA and DHA in a novel source: a variety of sausages. We screened 96 healthy volunteers, and recruited 44 with an Omega-3 Index <5%. Participants were randomly assigned to receive a variety of sausages enriched with approximately 250 mg EPA and DHA per 80 g (n = 22) daily for 8 weeks, or matching placebo sausages (n = 22). All sausages contained approximately 250 mg ALA/80 g. In the verum group, the mean Omega-3 Index increased from 4.18 ± 0.54 to 5.72 ± 0.66% (p < 0.001), while it remained unchanged in the placebo group. While ALA levels increased only in the placebo group, DPA levels increased in both groups. Inter-individual variability in the response was large. The mean increase of the Omega-3 Index per intake of EPA and DHA we observed was higher than for other sources previously studied, indicating superior bioavailability. As increasing production of EPA and DHA is difficult, improvements of bioavailability can facilitate reaching the target range for the Omega-3 Index (8–11%). PMID:28629180

Are There Changes in the Fatty Acid Profile of Breast Milk with Supplementation of Omega-3 Sources? A Systematic Review.

PubMed

Amaral, Yasmin Notarbartolo di Villarosa do; Marano, Daniele; Silva, Leila Maria Lopes da; Guimarães, Aline Carnevale Lia Dias; Moreira, Maria Elisabeth Lopes

2017-03-01

Purpose  To evaluate the effect of supplementation with omega-3 sources on the fatty acid composition of human milk. Methods  The review consisted of the search for articles published in PubMed, Biblioteca Virtual de Saúde (Virtual Health Library[VHL]) and Web of Science databases using the following keywords: fatty acids , omega-3 , human milk and supplementation ; for this purpose, we have used the program of research to integrate the services for the maintenance of autonomy (PRISMA) checklist. The following selection criteria were used: articles in English, Portuguese, Spanish or Italian, published between 2000 and 2015, and about studies performed in humans. We found 710 articles that met the established criteria; however, only 22 of them were selected to be part of this study. Results  All studies found a positive relationship between the consumption of omega-3 sources and their concentration in human milk. The differences in the findings are due to the distinct methods used, such as the specific time of the omega-3 supplementation, the type of omega-3 source offered, as well as the sample size. Conclusion  Although the studies were different in several methodological aspects, it was possible to observe the importance of omega-3 supplementation during gestation and/or the puerperium. Thieme-Revinter Publicações Ltda Rio de Janeiro, Brazil.

Influence of omega-3 fatty acids from the flaxseed (Linum usitatissimum) on the brain development of newborn rats.

PubMed

Lenzi Almeida, K C; Teles Boaventura, G; Guzmán Silva, M A

2011-01-01

The importance of essential fatty acids, in particular the omega-3 family, in the central nervous system development of newborns is well documented. The flaxseed (Linum usitatissimum) is considered one of the best vegetable sources of omega-3 fatty acids. The influence of omega-3 fatty acids from flaxseed on the brain development of newborn rats was evaluated. Pups of the F1 generation were obtained from 18 female Wistar rats divided in 3 groups (n=6), FG: fed with diet based on Flaxseed added with casein, CG: Casein, and MCG: Modified Casein supplemented with fibers and soybean oil. Newborn pups were weighted and submitted to euthanasia; brains were collected for evaluation of weight and lipid profile through gaseous chromatography. Significant increase in brain weight (39%) and relative brain weight (37%) was verified in pups from mothers fed with flaxseed diet. The omega-3 (n-3) fatty acids from the flaxseed were found in abundance in the diet made with this oleaginous and also significant increase in docosahexaenoic acid (DHA) (38%), as well as in total of omega-3 (n-3) fatty acids (62%). Maternal diet of flaxseed during pregnancy influences the incorporation of omega-3 fatty acid in the composition of brain tissue, assuring a good development of this organ in newborn rats.

Omega-3 prevents behavior response and brain oxidative damage in the ketamine model of schizophrenia.

PubMed

Zugno, A I; Chipindo, H L; Volpato, A M; Budni, J; Steckert, A V; de Oliveira, M B; Heylmann, A S; da Rosa Silveira, F; Mastella, G A; Maravai, S G; Wessler, P G; Binatti, A R; Panizzutti, B; Schuck, P F; Quevedo, J; Gama, C S

2014-02-14

Supplementation with omega-3 has been identified as an adjunctive alternative for the treatment of psychiatric disorders, in order to minimize symptoms. Considering the lack of understanding concerning the pathophysiology of schizophrenia, the present study hypothesized that omega 3 prevents the onset of symptoms similar to schizophrenia in young Wistar rats submitted to ketamine treatment. Moreover, the role of oxidative stress in this model was assessed. Omega-3 (0.8g/kg) or vehicle was given by orogastric gavage once daily. Both treatments were performed during 21days, starting at the 30th day of life in young rats. After 14days of treatment with omega-3 or vehicle, a concomitant treatment with saline or ketamine (25mg/kg ip daily) was started and maintained until the last day of the experiment. We evaluated the pre-pulse inhibition of the startle reflex, activity of antioxidant systems and damage to proteins and lipids. Our results demonstrate that supplementation of omega-3 prevented: decreased inhibition of startle reflex, damage to lipids in the hippocampus and striatum and damage to proteins in the prefrontal cortex. Furthermore, these changes are associated with decreased GPx in brain tissues evaluated. Together, our results suggest the prophylactic role of omega-3 against the outcome of symptoms associated with schizophrenia. Copyright © 2014. Published by Elsevier Ltd.

Potential applications of fish oils rich in omega-3 polyunsaturated fatty acids in the management of gastrointestinal cancer.

PubMed

Eltweri, A M; Thomas, A L; Metcalfe, M; Calder, P C; Dennison, A R; Bowrey, D J

2017-02-01

Despite advances in chemotherapeutic agents and surgical approaches for its management, gastrointestinal cancer still accounts for 27% of new cancer cases and 35% of cancer related mortality worldwide. Omega-3 polyunsaturated fatty acids (PUFAs) specifically eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have anti-inflammatory and anticancer activities and are used as immuno-nutrients. A literature search was conducted to identify primary research reporting on applications of the omega-3 PUFAs in gastrointestinal cancer. Reported laboratory studies indicate a clear role for omega-3 PUFAs in preventing cancer development at various stages including cancer cell proliferation, survival, angiogenesis, inflammation and metastasis. In clinical settings, omega-3 PUFAs have been reported to improve the immune response, maintain lean body mass, improve quality of life and improve overall survival in patients with colorectal and pancreatic cancer. In contrast to other GI cancers, there is a strong connection between inflammation and oesophageal cancer. Little work has been done exploring the role for omega-3 PUFAs in oesophageal cancer prevention and management. The authors are conducting a clinical trial investigating the use of parenteral omega-3 PUFAs supplementary to the standard of care (epirubicin, oxaliplatin and capecitabine palliative chemotherapy) in patients with advanced oesophagogastric cancer as a promising new therapeutic approach. Copyright © 2016 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.

Bioavailability of Dietary Omega-3 Fatty Acids Added to a Variety of Sausages in Healthy Individuals.

PubMed

Köhler, Anton; Heinrich, Johanna; von Schacky, Clemens

2017-06-19

A low Omega-3 Index (eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in erythrocytes) is associated with cardiac, cerebral, and other health issues. Intake of EPA and DHA, but not of alpha-linolenic acid (ALA), increases the Omega-3 Index. We investigated bioavailability, safety, palatability and tolerability of EPA and DHA in a novel source: a variety of sausages. We screened 96 healthy volunteers, and recruited 44 with an Omega-3 Index <5%. Participants were randomly assigned to receive a variety of sausages enriched with approximately 250 mg EPA and DHA per 80 g ( n = 22) daily for 8 weeks, or matching placebo sausages ( n = 22). All sausages contained approximately 250 mg ALA/80 g. In the verum group, the mean Omega-3 Index increased from 4.18 ± 0.54 to 5.72 ± 0.66% ( p < 0.001), while it remained unchanged in the placebo group. While ALA levels increased only in the placebo group, DPA levels increased in both groups. Inter-individual variability in the response was large. The mean increase of the Omega-3 Index per intake of EPA and DHA we observed was higher than for other sources previously studied, indicating superior bioavailability. As increasing production of EPA and DHA is difficult, improvements of bioavailability can facilitate reaching the target range for the Omega-3 Index (8-11%).

Prescription omega-3 fatty acid products containing highly purified eicosapentaenoic acid (EPA).

PubMed

Brinton, Eliot A; Mason, R Preston

2017-01-31

The omega-3 fatty acid eicosapentaenoic acid (EPA) has multiple actions potentially conferring cardiovascular benefit, including lowering serum triglyceride (TG) and non-high-density lipoprotein cholesterol (non-HDL-C) levels and potentially reducing key steps in atherogenesis. Dietary supplements are a common source of omega-3 fatty acids in the US, but virtually all contain docosahexaenoic acid (DHA) in addition to EPA, and lipid effects differ between DHA and EPA. Contrary to popular belief, no over-the-counter omega-3 products are available in the US, only prescription products and dietary supplements. Among the US prescription omega-3 products, only one contains EPA exclusively (Vascepa); another closely related prescription omega-3 product also contains highly purified EPA, but is approved only in Japan and is provided in different capsule sizes. These high-purity EPA products do not raise low-density lipoprotein cholesterol (LDL-C) levels, even in patients with TG levels >500 mg/dL, in contrast to the increase in LDL-C levels with prescription omega-3 products that also contain DHA. The Japanese prescription EPA product was shown to significantly reduce major coronary events in hypercholesterolemic patients when added to statin therapy in the Japan EPA Lipid Intervention Study (JELIS). The effects of Vascepa on cardiovascular outcomes are being investigated in statin-treated patients with high TG levels in the Reduction of Cardiovascular Events With EPA-Intervention Trial (REDUCE-IT).

Learning with the ATLAS Experiment at CERN

ERIC Educational Resources Information Center

Barnett, R. M.; Johansson, K. E.; Kourkoumelis, C.; Long, L.; Pequenao, J.; Reimers, C.; Watkins, P.

2012-01-01

With the start of the LHC, the new particle collider at CERN, the ATLAS experiment is also providing high-energy particle collisions for educational purposes. Several education projects--education scenarios--have been developed and tested on students and teachers in several European countries within the Learning with ATLAS@CERN project. These…

First experience with the new .cern Top Level Domain

NASA Astrophysics Data System (ADS)

Alvarez, E.; Malo de Molina, M.; Salwerowicz, M.; Silva De Sousa, B.; Smith, T.; Wagner, A.

2017-10-01

In October 2015, CERN’s core website has been moved to a new address, http://home.cern, marking the launch of the brand new top-level domain .cern. In combination with a formal governance and registration policy, the IT infrastructure needed to be extended to accommodate the hosting of Web sites in this new top level domain. We will present the technical implementation in the framework of the CERN Web Services that allows to provide virtual hosting, a reverse proxy solution and that also includes the provisioning of SSL server certificates for secure communications.

Omega-3 Fatty Acids for Autistic Spectrum Disorder: A Systematic Review

ERIC Educational Resources Information Center

Bent, Stephen; Bertoglio, Kiah; Hendren, Robert L.

2009-01-01

We conducted a systematic review to determine the safety and efficacy of omega-3 fatty acids for autistic spectrum disorder (ASD). Articles were identified by a search of MEDLINE, EMBASE, and the Cochrane Database using the terms autism or autistic and omega-3 fatty acids. The search identified 143 potential articles and six satisfied all…

75 FR 62422 - Notice of Lodging of Consent Decree Under the Comprehensive Environmental Response, Compensation...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-08

..., Inc., Case No. CV10-7032 GAF (AJWx) (C.D. Cal.), with respect to the Omega Chemical Superfund Site, located in Whittier, Los Angeles County, California (the ``Omega Site'') and the Casmalia Resources... Resources Site Special Account. The remaining amount ($482,100) will be applied towards the Omega Chemical...

40 CFR 721.9582 - Certain perfluoroalkyl sulfonates.

Code of Federal Regulations, 2012 CFR

2012-07-01

...-0319306979-40-8 Poly(oxy-1,2-ethanediyl), .alpha.-[2-(methylamino)ethyl]-.omega.-[(1,1,3,3-tetramethylbutyl...]amino]ethyl]-.omega.-hydroxy- 38850-52-1 1-Propanaminium, 3-[(carboxymethyl)[(1,1,2,2,3,3,4,4,5,5,6,6,6...-heptadecafluorooctyl)sulfonyl]methylamino]carbonyl]-.omega.-butoxy- 52166-82-2 1-Propanaminium, N,N,N-trimethyl-3-[[(1...

40 CFR 721.9582 - Certain perfluoroalkyl sulfonates.

Code of Federal Regulations, 2013 CFR

2013-07-01

...-0319306979-40-8 Poly(oxy-1,2-ethanediyl), .alpha.-[2-(methylamino)ethyl]-.omega.-[(1,1,3,3-tetramethylbutyl...]amino]ethyl]-.omega.-hydroxy- 38850-52-1 1-Propanaminium, 3-[(carboxymethyl)[(1,1,2,2,3,3,4,4,5,5,6,6,6...-heptadecafluorooctyl)sulfonyl]methylamino]carbonyl]-.omega.-butoxy- 52166-82-2 1-Propanaminium, N,N,N-trimethyl-3-[[(1...

40 CFR 721.9582 - Certain perfluoroalkyl sulfonates.

Code of Federal Regulations, 2011 CFR

2011-07-01

...-0319306979-40-8 Poly(oxy-1,2-ethanediyl), .alpha.-[2-(methylamino)ethyl]-.omega.-[(1,1,3,3-tetramethylbutyl...]amino]ethyl]-.omega.-hydroxy- 38850-52-1 1-Propanaminium, 3-[(carboxymethyl)[(1,1,2,2,3,3,4,4,5,5,6,6,6...-heptadecafluorooctyl)sulfonyl]methylamino]carbonyl]-.omega.-butoxy- 52166-82-2 1-Propanaminium, N,N,N-trimethyl-3-[[(1...

40 CFR 721.9582 - Certain perfluoroalkyl sulfonates.

Code of Federal Regulations, 2010 CFR

2010-07-01

...-0319306979-40-8 Poly(oxy-1,2-ethanediyl), .alpha.-[2-(methylamino)ethyl]-.omega.-[(1,1,3,3-tetramethylbutyl...]amino]ethyl]-.omega.-hydroxy- 38850-52-1 1-Propanaminium, 3-[(carboxymethyl)[(1,1,2,2,3,3,4,4,5,5,6,6,6...-heptadecafluorooctyl)sulfonyl]methylamino]carbonyl]-.omega.-butoxy- 52166-82-2 1-Propanaminium, N,N,N-trimethyl-3-[[(1...

Reduction of omega-3 oil oxidation in stable emulsion of caseinate-omega-3 oil-oat beta-glucan

USDA-ARS?s Scientific Manuscript database

Lipid oxidation, particularly oxidation of unsaturated fatty acids such as omega-3 fatty acids, has posed a serious challenge to the food industry trying to incorporate heart-healthy oil products into their lines of healthful foods and beverages. In this study, heart healthy plant and marine based o...

Pharmacological identification of a novel Ca2+ channel in chicken brain synaptosomes.

PubMed

Lundy, P M; Hamilton, M G; Frew, R

1994-04-18

Ca2+ influx was measured in rat and chicken brain synaptosomes in the presence of a number of pharmacological tools which have recently been used to define voltage-sensitive Ca(2+)-channel (VSCC) types. In chicken brain synaptosomes. VSCCs which, because of their sensitivity to inhibition by omega-conotoxin (omega-CgTx), are thought to be exclusively N-type, the P-type VSCC polyamine inhibitor FTX (from Agelenopsis aperta venom; 1 microliters/ml), its synthetic analogue, sFTX (1-5 mM) and the polypeptides AgaIVA (IC50 0.29 microM) and omega-CgTx MVIIC (IC50 0.0022 microM) inhibited 70-100% of the measurable K+ stimulated Ca2+ influx. The prototypical N-channel VSCC inhibitor omega-CgTx GVIA (IC50 0.014 microM), Cd2+ (50 microM) and diluted venom from Hololena curta (1:2,500) also caused complete or almost complete, inhibition of Ca2+ influx. In comparable studies using rat brain synaptosomes, sFTX (1-10 mM) caused a dose-dependent reduction of Ca2+ influx, while FTX (1 microliters/ml) and AgaIVA (IC50 0.02 microM) completely inhibited Ca2+ influx. Similar to the findings in chicken synaptosomes, Cd2+ (50 microM) and H. curta (1:2,500 dilution) both inhibited K+ stimulated influx by > 80% whereas omega-CgTx (1 microM) only caused a maximum 25% inhibition. Both sFTX and its congener spermine, inhibited [125I]omega-CgTx binding to rat and chicken synaptosomal membranes. These results strongly implicate P-type channels as the major VSCC in rat brain. The results also clearly demonstrate a heretofore unrecognized, novel, FTX/AgaIVA/omega-CgTx GVIA/omega-CgTx MVIIC-sensitive VSCC in chicken brain.

Omega-3 fatty acids, inflammatory status and biochemical markers of patients with systemic lupus erythematosus: a pilot study.

PubMed

Curado Borges, Mariane; de Miranda Moura Dos Santos, Fabiana; Weiss Telles, Rosa; Melo de Andrade, Marcus Vinícius; Toulson Davisson Correia, Maria Isabel; Lanna, Cristina Costa Duarte

Studies have shown that omega-3 fatty acids reduce the concentrations of eicosanoids, cytokines, chemokines, C-reactive protein (CRP) and other inflammatory mediators. To investigate the effects of omega-3 fatty acids on circulating levels of inflammatory mediators and biochemical markers in women with systemic lupus erythematosus (SLE). Experimental clinical study (clinical trial: NCT02524795); 49 women with SLE (ACR1982/1997) were randomized: 22 to the omega-3 group (daily intake of 1080mg EPA+200mg DHA, for 12 weeks) and 27 to the control group. The inflammatory mediators and biochemical markers at T0 and T1 in omega-3 group were compared using Wilcoxon test. U-Mann-Whitney test was used to compare variations of measured variables [ΔV=pre-treatment (T0)-post-treatment (T1) concentrations] between groups. p<0.05 was considered significant. The median (interquartile range - IQR) of age was 37 (29-48) years old, of disease duration was 7 (4-13) years, and of SLEDAI-2K was 1 (0-2). The median (IQR) of variation in CRP levels between the two groups showed a decrease in omega-3 group while there was an increase in control group (p=0.008). The serum concentrations of IL-6 and IL-10, leptin and adiponectin did not change after a 12 week treatment. Supplementation with omega-3 had no impact on serum concentrations of IL-6, IL-10, leptin and adiponectin in women with SLE and low disease activity. There was a significant decrease of CRP levels as well as evidence that omega-3 may impact total and LDL-cholesterol. Copyright © 2016. Published by Elsevier Editora Ltda.

Chronic administration of docosahexaenoic acid or eicosapentaenoic acid, but not arachidonic acid, alone or in combination with uridine, increases brain phosphatide and synaptic protein levels in gerbils.

PubMed

Cansev, M; Wurtman, R J

2007-08-24

Synthesis of phosphatidylcholine, the most abundant brain membrane phosphatide, requires three circulating precursors: choline; a pyrimidine (e.g. uridine); and a polyunsaturated fatty acid. Supplementing a choline-containing diet with the uridine source uridine-5'-monophosphate (UMP) or, especially, with UMP plus the omega-3 fatty acid docosahexaenoic acid (given by gavage), produces substantial increases in membrane phosphatide and synaptic protein levels within gerbil brain. We now compare the effects of various polyunsaturated fatty acids, given alone or with UMP, on these synaptic membrane constituents. Gerbils received, daily for 4 weeks, a diet containing choline chloride with or without UMP and/or, by gavage, an omega-3 (docosahexaenoic or eicosapentaenoic acid) or omega-6 (arachidonic acid) fatty acid. Both of the omega-3 fatty acids elevated major brain phosphatide levels (by 18-28%, and 21-27%) and giving UMP along with them enhanced their effects significantly. Arachidonic acid, given alone or with UMP, was without effect. After UMP plus docosahexaenoic acid treatment, total brain phospholipid levels and those of each individual phosphatide increased significantly in all brain regions examined (cortex, striatum, hippocampus, brain stem, and cerebellum). The increases in brain phosphatides in gerbils receiving an omega-3 (but not omega-6) fatty acid, with or without UMP, were accompanied by parallel elevations in levels of pre- and post-synaptic proteins (syntaxin-3, PSD-95 and synapsin-1) but not in those of a ubiquitous structural protein, beta-tubulin. Hence administering omega-3 polyunsaturated fatty acids can enhance synaptic membrane levels in gerbils, and may do so in patients with neurodegenerative diseases, especially when given with a uridine source, while the omega-6 polyunsaturated fatty acid arachidonic acid is ineffective.

Chronic administration of docosahexaenoic acid or eicosapentaenoic acid, but not arachidonic acid, alone or in combination with uridine, increases brain phosphatide and synaptic protein levels in gerbils

PubMed Central

Cansev, M.; Wurtman, R. J.

2007-01-01

Synthesis of phosphatidylcholine, the most abundant brain membrane phosphatide, requires three circulating precursors: choline; a pyrimidine (e.g., uridine); and a polyunsaturated fatty acid. Supplementing a choline-containing diet with the uridine source uridine-5′-monophosphate (UMP) or, especially, with UMP plus the omega-3 fatty acid docosahexaenoic acid (given by gavage), produces substantial increases in membrane phosphatide and synaptic protein levels within gerbil brain. We now compare the effects of various polyunsaturated fatty acids, given alone or with UMP, on these synaptic membrane constituents. Gerbils received, daily for 4 weeks, a diet containing choline chloride with or without UMP and/or, by gavage, an omega-3 (docosahexaenoic or eicosapentaenoic acid) or omega-6 (arachidonic acid) fatty acid. Both of the omega-3 fatty acids elevated major brain phosphatide levels (by 18-28%, and 21-27%) and giving UMP along with them enhanced their effects significantly. Arachidonic acid, given alone or with UMP, was without effect. After UMP plus docosahexaenoic acid treatment, total brain phospholipids levels and those of each individual phosphatide increased significantly in all brain regions examined (cortex, striatum, hippocampus, brain stem, and cerebellum). The increases in brain phosphatides in gerbils receiving an omega-3 (but not omega-6) fatty acid, with or without UMP, were accompanied by parallel elevations in levels of pre- and post-synaptic proteins (syntaxin-3, PSD-95 and Synapsin-1) but not in those of a ubiquitous structural protein, β-tubulin. Hence administering omega-3 polyunsaturated fatty acids can enhance synaptic membrane levels in gerbils, and may do so in patients with neurodegenerative diseases, especially when given with a uridine source, while the omega-6 polyunsaturated fatty acid arachidonic acid is ineffective. PMID:17683870

Omega-3 supplementation effects on polycystic ovary syndrome symptoms and metabolic syndrome.

PubMed

Khani, Behnaz; Mardanian, Farahnaz; Fesharaki, Sajadeh Jafari

2017-01-01

Polycystic ovary syndrome (PCOS) is the most common female endocrine disorder with unknown etiology and with different complications. The aim of this study was to evaluate the effect of omega-3 supplementation on PCOS symptoms and metabolic syndrome. This double-blind clinical trial was performed in 2015 in Alzahra and Shahid Beheshti Hospitals, Isfahan, Iran, on 88 patients with PCOS. Intervention group took omega-3 supplements with dose of 2 g/day for 6 months (two capsules), but control group received two olive oil capsules. Finally, ultrasound and laboratory findings and the recovery rate of menstrual disorders in both groups were compared. After 6 months' intervention, waist circumference (WC) was significantly lower in omega-3 as compared to control (81.18 ± 2.87 vs. 84.22 ± 2.61 cm, respectively, P < 0.0001). High-density lipoprotein was increased (47.2 ± 1.37 vs. 41.56 ± 1.34 mg/dl, respectively, P < 0.0001) while low-density lipoprotein (107.79 ± 1.68 vs. 117.4 ± 1.57 mg/dl, respectively), triglyceride (116.02 ± 3.13 vs. 125.06 ± 2.91 mg/dl, respectively), and cholesterol (180.34 ± 6.34 vs. 189.56 ± 5.93 mg/dl, respectively) in omega-3 were significantly lower than control ( P < 0.0001). The interval between periods in omega-3 was significantly shorter than control (29.83 ± 4.68 vs. 47.11 ± 8.72 days, respectively, P < 0.001). Omega-3 decrease lipid profiles, WC, and interval between periods while weight, hip circumference, fasting blood sugar, number of ovarian follicle, size of ovary, bleeding volume, menstrual bleeding, and hirsutism score did not change by administration of omega-3.

Internet-Based, Randomized Controlled Trial of Omega-3 Fatty Acids for Hyperactivity in Autism

PubMed Central

Bent, Stephen; Hendren, Robert L.; Zandi, Tara; Law, Kiely; Choi, Jae-Eun; Widjaja, Felicia; Kalb, Luther; Nestle, Jay; Law, Paul

2014-01-01

Objective Preliminary evidence suggests that omega-3 fatty acids may reduce hyperactivity in children with autism spectrum disorder (ASD). We sought to examine the feasibility of a novel, internet-based clinical trial design to evaluate the efficacy of this supplement. Method E-mail invitations were sent to parents of children aged 5-8 enrolled in the Interactive Autism Network. All study procedures, including screening, informed consent, and collection of outcome measures took place over the internet. The primary outcome measures were parent- and teacher-rated changes in hyperactivity on the Aberrant Behavior Checklist. Results During the 6-week recruitment period, 57 children from 28 states satisfied all eligibility criteria and were randomly assigned to 1.3 grams of omega-3 fatty acids or an identical placebo daily for 6 weeks. Outcome assessments were obtained from all 57 participants and 57 teachers, and the study was completed in 3 months. Children in the omega-3 fatty acid group had a greater reduction in hyperactivity (-5.3 points) compared to the placebo group (-2.6 points), but the difference was not statistically significant (1.9 point greater improvement in the omega-3 group, 95% CI -2.2 to 5.2). Side effects were rare and not associated with omega-3 fatty acids. Participant feedback was positive. Conclusion Internet-based randomized controlled trials of therapies in children with ASD are feasible and may lead to marked reductions in the time and cost of completing trials. A larger sample size is required to definitively determine the efficacy of omega-3 fatty acids. Clinical trial registration information—Omega-3 Fatty Acids for Hyperactivity Treatment in Autism Spectrum Disorder; http://clinicaltrials.gov; NCT01694667. PMID:24839884

Fishy Business: Effect of Omega-3 Fatty Acids on Zinc Transporters and Free Zinc Availability in Human Neuronal Cells

PubMed Central

De Mel, Damitha; Suphioglu, Cenk

2014-01-01

Omega-3 (ω-3) fatty acids are one of the two main families of long chain polyunsaturated fatty acids (PUFA). The main omega-3 fatty acids in the mammalian body are α-linolenic acid (ALA), docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA). Central nervous tissues of vertebrates are characterized by a high concentration of omega-3 fatty acids. Moreover, in the human brain, DHA is considered as the main structural omega-3 fatty acid, which comprises about 40% of the PUFAs in total. DHA deficiency may be the cause of many disorders such as depression, inability to concentrate, excessive mood swings, anxiety, cardiovascular disease, type 2 diabetes, dry skin and so on. On the other hand, zinc is the most abundant trace metal in the human brain. There are many scientific studies linking zinc, especially excess amounts of free zinc, to cellular death. Neurodegenerative diseases, such as Alzheimer’s disease, are characterized by altered zinc metabolism. Both animal model studies and human cell culture studies have shown a possible link between omega-3 fatty acids, zinc transporter levels and free zinc availability at cellular levels. Many other studies have also suggested a possible omega-3 and zinc effect on neurodegeneration and cellular death. Therefore, in this review, we will examine the effect of omega-3 fatty acids on zinc transporters and the importance of free zinc for human neuronal cells. Moreover, we will evaluate the collective understanding of mechanism(s) for the interaction of these elements in neuronal research and their significance for the diagnosis and treatment of neurodegeneration. PMID:25195602

Tissue Fatty Acid Profile is Differently Modulated from Olive Oil and Omega-3 Polyunsaturated Fatty Acids in ApcMin/+ Mice.

PubMed

Tutino, Valeria; Caruso, Maria G; De Leonardis, Giampiero; De Nunzio, Valentina; Notarnicola, Maria

2017-11-16

Fatty acid profile can be considered an appropriate biomarker for investigating the relations between the patterns of fatty acid metabolism and specific diseases, as cancer, cardiovascular and degenerative diseases. Aim of this study was to test the effects of diets enriched with olive oil and omega-3 Polyunsaturated Fatty Acids (PUFAs) on fatty acid profile in intestinal tissue of ApcMin/+ mice. Three groups of animals were considered: control group, receiving a standard diet; olive oilgroup, receiving a standard diet enriched with olive oil; omega-3 group, receiving a standard diet enriched with salmon fish. Tissue fatty acid profile was evaluated by gas chromatography method. Olive oil and omega-3 PUFAs in the diet differently affect the tissue fatty acid profile. Compared to control group, the levels of Saturated Fatty Acids (SFAs) were lower in olive oil group, while an increase of SFAs was found in omega-3 group. Monounsaturated Fatty Acids (MUFAs) levels were enhanced after olive oil treatment, and in particular, a significant increase of oleic acid levels was detected; MUFAs levels were instead reduced in omega-3 group in line with the decrease of oleic acid levels. The total PUFAs levels were lower in olive oil respect to control group. Moreover, a significant induction of Saturation Index (SI) levels was observed after omega-3 PUFAs treatment, while its levels were reduced in mice fed with olive oil. Our data demonstrated a different effect of olive oil and omega-3 PUFAs on tissue lipid profile in APCMin/+ mice. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Coherent and phase-sensitive phenomena of ultrashort laser pulses propagating in three-level {lambda}-type systems studied with the finite-difference time-domain method

DOE Office of Scientific and Technical Information (OSTI.GOV)

Loiko, Yurii; Institute of Molecular and Atomic Physics, National Academy of Sciences of Belarus, Nezaleznasty Ave. 70, 220072 Minsk; Serrat, Carles

2006-06-15

Propagation of single- and two-color hyperbolic secant femtosecond laser pulses in a three-level {lambda}-type quantum system is investigated by solving the Maxwell and density matrix equations with the finite-difference time-domain and Runge-Kutta methods. As a first study of our modeling, we simulate pulse self-induced transparency (SIT) in two-level systems and see how this phenomenon can be controlled by manipulating the initial relative phase between the SIT pulse and a second control pulse, provided the ratio between both pulse frequencies obeys the relation {omega}{sub 1}/{omega}{sub 2}=3. We then examine frequency down-conversion processes that are observed with single- and two-color pulses themore » envelope area of which is equal to or a multiple of 2{pi}, for pulse frequencies close to resonance with the transitions of a three-level {lambda} medium. Also, phase-sensitive phenomena are discussed in the case of two-color {omega}-3{omega} pulses propagating resonantly in the three-level system. In particular, possibilities for such coherent control are found for frequency down-conversion processes when the ratio of the frequencies of optical transitions is {omega}{sub 13}/{omega}{sub 12}=3. The conditions for quantum control of four-wave mixing processes are also examined when the pulse frequencies of two-color {omega}-3{omega} pulses are far from any resonance of the three-level system. We demonstrate the possibility to cancel the phase sensitivity of the four-wave coupling in a {lambda}-type system by competition effects between optical transitions.« less

Omega-3 PUFA concentration by a novel PVDF nano-composite membrane filled with nano-porous silica particles.

PubMed

Ghasemian, Samaneh; Sahari, Mohammad Ali; Barzegar, Mohsen; Ahmadi Gavlighi, Hasan

2017-09-01

In this study, polyvinylidene fluoride (PVDF) and nano-porous silica particle were used to fabricate an asymmetric nano-composite membrane. Silica particles enhanced the thermal stability of PVDF/SiO 2 membranes; increasing the decomposition temperature from 371°C to 408°C. Cross sectional morphology showed that silica particles were dispersed in polymer matrix uniformly. However, particle agglomeration was found at higher loading of silica (i.e., 20 by weight%). The separation performance of nano-composite membranes was also evaluated using the omega-3 polyunsaturated fatty acids (PUFA) concentration at a temperature and pressure of 30°C and 4bar, respectively. Silica particle increased the omega-3PUFA concentration from 34.8 by weight% in neat PVDF to 53.9 by weight% in PVDF with 15 by weight% of silica. Moreover, PVDF/SiO 2 nano-composite membranes exhibited enhanced anti-fouling property compared to neat PVDF membrane. Fouling mechanism analysis revealed that complete pore blocking was the predominant mechanism occurring in oil filtration. The concentration of omega-3 polyunsaturated fatty acids (PUFA) is important in the oil industries. While the current methods demand high energy consumptions in concentrating the omega-3, membrane separation technology offers noticeable advantages in producing pure omega-3 PUFA. Moreover, concentrating omega-3 via membrane separation produces products in the triacylglycerol form which possess better oxidative stability. In this work, the detailed mechanisms of fouling which limits the performance of membrane separation were investigated. Incorporating silica particles to polymeric membrane resulted in the formation of mixed matrix membrane with improved anti-fouling behaviour compared to the neat polymeric membrane. Hence, the industrial potential of membrane processing to concentrate omega-3 fatty acids is enhanced. Copyright © 2017. Published by Elsevier Ltd.

Omega-3 supplementation on inflammatory markers in patients with chronic Chagas cardiomyopathy: a randomized clinical study.

PubMed

Silva, Paula Simplício da; Mediano, Mauro Felippe Felix; Silva, Gilberto Marcelo Sperandio da; Brito, Patricia Dias de; Cardoso, Claudia Santos de Aguiar; Almeida, Cristiane Fonseca de; Sangenis, Luiz Henrique Conde; Pinheiro, Roberta Olmo; Hasslocher-Moreno, Alejandro Marcel; Brasil, Pedro Emmanuel Alvarenga Americano do; Sousa, Andrea Silvestre de

2017-06-09

Several studies have been focusing on the effect of omega-3 polyunsaturated fatty acids on modulation of inflammatory markers in several cardiopathies. Although immunoregulatory dysfunction has been associated to the chronic cardiac involvement in Chagas disease, there is no study examining the effects of omega-3 supplementation in these patients. We investigated the effects of omega-3 PUFAs on markers of inflammation and lipid profile in chronic Chagas cardiomyopathy patients. The present study was a single-center double-blind clinical trial including patients with chronic Chagas cardiomyopathy. Patients were randomly assigned to receive omega-3 PUFAs capsules (1.8g EPA and 1.2g DHA) or placebo (corn oil) during an 8-week period. Cytokines, fasting glucose, lipid, and anthropometric profiles were evaluated. Forty-two patients (23 women and 19 men) were included in the study and there were only two losses to follow-up during the 8-week period. Most of sociodemographic and clinical characteristics were similar between the groups at baseline, except for the cytokines IL-1β, IL-6, IL-8, IL-10, IL-17α, and IFNγ. The omega-3 PUFAs group demonstrated greater improvements in serum triglycerides (-21.1 vs. -4.1; p = 0.05) and IL-10 levels (-10.6 vs. -35.7; p = 0.01) in comparison to controls after 8 weeks of intervention. No further differences were observed between groups. Omega-3 PUFAs supplementation may favorably affect lipid and inflammatory profile in chronic Chagas cardiomyopathy patients, demonstrated by a decrease in triglycerides and improvements on IL-10 concentration. Further studies examining the clinical effects of omega-3 fatty acids supplementation in chronic Chagas cardiomyopathy are necessary. NCT01863576.

Omega-oxidation is the major pathway for the catabolism of leukotriene B4 in human polymorphonuclear leukocytes.

PubMed

Shak, S; Goldstein, I M

1984-08-25

Leukotriene B4 (LTB4), formed by the 5-lipoxygenase pathway in human polymorphonuclear leukocytes (PMN), may be an important mediator of inflammation. Recent studies suggest that human leukocytes can convert LTB4 to products that are less biologically active. To examine the catabolism of LTB4, we developed (using high performance liquid chromatography) a sensitive, reproducible assay for this mediator and its omega-oxidation products (20-OH- and 20-COOH-LTB4). With this assay, we have found that human PMN (but not human monocytes, lymphocytes, or platelets) convert exogenous LTB4 almost exclusively to 20-OH- and 20-COOH-LTB4 (identified by gas chromatography-mass spectrometry). Catabolism of exogenous LTB4 by omega-oxidation is rapid (t1/2 approximately 4 min at 37 degrees C in reaction mixtures containing 1.0 microM LTB4 and 20 X 10(6) PMN/ml), temperature-dependent (negligible at 0 degrees C), and varies with cell number as well as with initial substrate concentration. The pathway for omega-oxidation in PMN is specific for LTB4 and 5(S),12(S)-dihydroxy-6,8,10,14-eicosatetraenoic acid (only small amounts of other dihydroxylated-derivatives of arachidonic acid are converted to omega-oxidation products). Even PMN that are stimulated by phorbol myristate acetate to produce large amounts of superoxide anion radicals catabolize exogenous leukotriene B4 primarily by omega-oxidation. Finally, LTB4 that is generated when PMN are stimulated with the calcium ionophore, A23187, is rapidly catabolized by omega-oxidation. Thus, human PMN not only generate and respond to LTB4, but also rapidly and specifically catabolize this mediator by omega-oxidation.

N-3 Polyunsaturated Fatty Acids through the Lifespan: Implication for Psychopathology

PubMed Central

Pusceddu, Matteo M.; Kelly, Philip; Stanton, Catherine; Cryan, John F.

2016-01-01

Objective: The impact of lifetime dietary habits and their role in physical, mental, and social well-being has been the focus of considerable recent research. Omega-3 polyunsaturated fatty acids as a dietary constituent have been under the spotlight for decades. Omega-3 polyunsaturated fatty acids constitute key regulating factors of neurotransmission, neurogenesis, and neuroinflammation and are thereby fundamental for development, functioning, and aging of the CNS. Of note is the fact that these processes are altered in various psychiatric disorders, including attention deficit hyperactivity disorder, depression, and Alzheimer’s disease. Design: Relevant literature was identified through a search of MEDLINE via PubMed using the following words, “n-3 PUFAs,” “EPA,” and “DHA” in combination with “stress,” “cognition,” “ADHD,” “anxiety,” “depression,” “bipolar disorder,” “schizophrenia,” and “Alzheimer.” The principal focus was on the role of omega-3 polyunsaturated fatty acids throughout the lifespan and their implication for psychopathologies. Recommendations for future investigation on the potential clinical value of omega-3 polyunsaturated fatty acids were examined. Results: The inconsistent and inconclusive results from randomized clinical trials limits the usage of omega-3 polyunsaturated fatty acids in clinical practice. However, a body of literature demonstrates an inverse correlation between omega-3 polyunsaturated fatty acid levels and quality of life/ psychiatric diseases. Specifically, older healthy adults showing low habitual intake of omega-3 polyunsaturated fatty acids benefit most from consuming them, showing improved age-related cognitive decline. Conclusions: Although further studies are required, there is an exciting and growing body of research suggesting that omega-3 polyunsaturated fatty acids may have a potential clinical value in the prevention and treatment of psychopathologies. PMID:27608809

Plasma and erythrocyte uptake of omega-3 fatty acids from an intravenous fish oil based lipid emulsion in patients with advanced oesophagogastric cancer.

PubMed

Eltweri, A M; Thomas, A L; Fisk, H L; Arshad, A; Calder, P C; Dennison, A R; Bowrey, D J

2017-06-01

It has been demonstrated that short term intravenous (IV) administration of omega-3 polyunsaturated fatty acids (PUFAs) is more effective than oral supplementation at promoting incorporation of the bioactive omega-3 PUFAs eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) into plasma, blood cells and tissues. The effect of repeated short term IV infusion of omega-3 PUFAs was investigated in patients with advanced oesophagogastric cancer during palliative chemotherapy. Patients with advanced oesophagogastric cancer (n = 21) were recruited into a phase II pilot clinical trial. All patients were scheduled for an intravenous infusion of Omegaven ® (fish oil supplement containing EPA and DHA) at a rate of 2 ml/kg body weight for 4 h once a week for up to six months. Blood samples were collected to assess omega-3 PUFA uptake into plasma non-esterified fatty acids (NEFAs) and phosphatidylcholine (PC) and into red blood cell (RBC) membranes. Fatty acid profiles were analysed by gas chromatography. Twenty patients received at least one Omegaven ® treatment and were included in the analysis. Each infusion of omega-3 PUFAs resulted in increased EPA and DHA in plasma NEFAs, but there was little effect on PUFAs within plasma PC during the infusions. However, with repeated weekly infusion of omega-3 PUFAs, the EPA content of plasma PC and of RBC membranes increased. Repeated weekly omega-3 PUFA infusion is effective in enriching plasma PC and RBC membranes in EPA in patients with advanced oesophagogastric cancer receiving palliative chemotherapy. Clinical Trials.Gov NCT01870791. Copyright © 2016 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.

Effects of omega-3 fatty acids on arterial stiffness in patients with hypertension: a randomized pilot study.

PubMed

Krantz, Mori J; Havranek, Edward P; Pereira, Rocio I; Beaty, Brenda; Mehler, Philip S; Long, Carlin S

2015-12-02

Omega-3 fatty acids prevent cardiovascular disease (CVD) events in patients with myocardial infarction or heart failure. Benefits in patients without overt CVD have not been demonstrated, though most studies did not use treatment doses (3.36 g) of omega-3 fatty acids. Arterial stiffness measured by pulse wave velocity (PWV) predicts CVD events independent of standard risk factors. However, no therapy has been shown to reduce PWV in a blood pressure-independent manner. We assessed the effects of esterified omega-3 fatty acids on PWV and serum markers of inflammation among patients with hypertension. We performed a prospective, randomized; double-blinded pilot study of omega-3 fatty acids among 62 patients in an urban, safety net hospital. Patients received 3.36 g of omega-3 fatty acids vs. matched placebo daily for 3-months. The principal outcome measure was change in brachial-ankle PWV. Serum inflammatory markers associated with CVD risk were also assessed. The majority (71 %) were of Latino ethnicity. After 3-months, mean change in arterial PWV among omega-3 and placebo groups was -97 cm/s vs. -33 cm/s respectively (p = 0.36 for difference, after multivariate adjustment for baseline age, systolic blood pressure, and serum adiponectin). Non-significant reductions in lipoprotein-associated phospholipase A2 (LpPLA2) mass and high sensitivity C-reactive protein (hsCRP) relative to placebo were also observed (p = 0.08, and 0.21, respectively). High-dose omega-3 fatty acids did not reduce arterial PWV or markers of inflammation among patients within a Latino-predominant population with hypertension. NCT00935766 , registered July 8 2009.

Effects of omega-3 fatty acids on depression and quality of life in maintenance hemodialysis patients.

PubMed

Dashti-Khavidaki, Simin; Gharekhani, Afshin; Khatami, Mohammad-Reza; Miri, Elham-Sadat; Khalili, Hossein; Razeghi, Effat; Hashemi-Nazari, Seyed-Saeed; Mansournia, Mohammad-Ali

2014-01-01

Depression and health-related quality of life (HRQoL) are closely interrelated among hemodialysis (HD) patients and associated with negative impacts on patients' clinical outcomes. Considering previous reports on clinical benefits of omega-3 fatty acids in major depression and HRQoL in other patient populations, this study examined effects of omega-3 fatty acids on depression and HRQoL in chronic HD patients. In this randomized placebo-controlled trial, 40 adult patients with a Beck Depression Inventory (BDI) score of ≥16 and HD vintage of at least 3 months were randomized to ingest 6 soft-gel capsules of either omega-3 fatty acids (180 mg eicosapentaenoic acid and 120 mg docosahexaenoic acid in each capsule) or corresponding placebo, daily for 4 months. At baseline and after 4 months, 2 questionnaires of BDI and the Medical Outcome Study 36-Item Short-Form Health Survey were completed by each patient. Although baseline BDI score was comparable between the 2 groups, it was significantly lower in the omega-3 group compared with the placebo group at the end of the study (P = 0.008). Except for mental health, social functioning, and general health, other domains of HRQoL showed significant improvement in the omega-3 group compared with the placebo group at month 4 of the study (P < 0.05 for all). Regression analysis revealed that ameliorated BDI score by omega-3 treatment had considerable role in the improvement of overall HRQoL score, physical and mental component dimensions, and score of physical functioning, role-physical, and bodily pain. Supplemental use of omega-3 fatty acids in HD patients with depressive symptoms seems to be efficacious in improving depressive symptoms and HRQoL.

Associations of maternal long-chain polyunsaturated fatty acids, methyl mercury, and infant development in the Seychelles Child Development Nutrition Study.

PubMed

Strain, J J; Davidson, Philip W; Bonham, Maxine P; Duffy, Emeir M; Stokes-Riner, Abbie; Thurston, Sally W; Wallace, Julie M W; Robson, Paula J; Shamlaye, Conrad F; Georger, Lesley A; Sloane-Reeves, Jean; Cernichiari, Elsa; Canfield, Richard L; Cox, Christopher; Huang, Li Shan; Janciuras, Joanne; Myers, Gary J; Clarkson, Thomas W

2008-09-01

Fish consumption during gestation can provide the fetus with long-chain polyunsaturated fatty acids (LCPUFA) and other nutrients essential for growth and development of the brain. However, fish consumption also exposes the fetus to the neurotoxicant, methyl mercury (MeHg). We studied the association between these fetal exposures and early child development in the Seychelles Child Development Nutrition Study (SCDNS). Specifically, we examined a priori models of Omega-3 and Omega-6 LCPUFA measures in maternal serum to test the hypothesis that these LCPUFA families before or after adjusting for prenatal MeHg exposure would reveal associations with child development assessed by the BSID-II at ages 9 and 30 months. There were 229 children with complete outcome and covariate data available for analysis. At 9 months, the PDI was positively associated with total Omega-3 LCPUFA and negatively associated with the ratio of Omega-6/Omega-3 LCPUFA. These associations were stronger in models adjusted for prenatal MeHg exposure. Secondary models suggested that the MeHg effect at 9 months varied by the ratio of Omega-6/Omega-3 LCPUFA. There were no significant associations between LCPUFA measures and the PDI at 30 months. There were significant adverse associations, however, between prenatal MeHg and the 30-month PDI when the LCPUFA measures were included in the regression analysis. The BSID-II mental developmental index (MDI) was not associated with any exposure variable. These data support the potential importance to child development of prenatal availability of Omega-3 LCPUFA present in fish and of LCPUFA in the overall diet. Furthermore, they indicate that the beneficial effects of LCPUFA can obscure the determination of adverse effects of prenatal MeHg exposure in longitudinal observational studies.

The Effects of Omega-3 Fatty Acids Supplementation on Gene Expression Involved in the Insulin and Lipid Signaling Pathway in Patients with Polycystic Ovary Syndrome.

PubMed

Nasri, Khadijeh; Hantoushzadeh, Sedigheh; Aghadavod, Esmat; Taghizadeh, Mohsen; Asemi, Zatollah

2017-06-01

Limited data are available evaluating the effects of omega-3 fatty acids supplementation on gene expression involved in the insulin and lipid-signaling pathway in women with polycystic ovary syndrome (PCOS). This study was conducted to evaluate the effects of omega-3 fatty acids supplementation on gene expression involved in the insulin and lipid signaling pathway in women with PCOS. This randomized double blind, placebo-controlled trial was done among 60 women aged 18-40 years old and diagnosed with PCOS according to the Rotterdam criteria. Participants were randomly assigned into 2 groups to receive either 1 000 mg omega-3 fatty acids from flaxseed oil containing 400 mg α-linolenic acid (n=30) or placebo (n=30) twice a day for 12 weeks. Gene expressions involved in the insulin and lipid-signaling pathway were quantified in blood samples of PCOS women with RT-PCR method. Quantitative results of RT-PCR demonstrated that compared with the placebo, omega-3 fatty acids supplementation upregulated peroxisome proliferator-activated receptor gamma (PPAR-γ) mRNA (p=0.005) in peripheral blood mononuclear cells of women with PCOS. In addition, compared to the placebo, omega-3 fatty acids supplementation downregulated expressed levels of oxidized low-density lipoprotein receptor (LDLR) mRNA (p=0.002) in peripheral blood mononuclear cells of women with PCOS. We did not observe any significant effect of omega-3 fatty acids supplementation on expressed levels of glucose transporter 1 (GLUT-1) and lipoprotein(a) [Lp(a)] genes in peripheral blood mononuclear cells. Overall, omega-3 fatty acids supplementation for 12 weeks in PCOS women significantly improved gene expression of PPAR-γ and LDLR. © Georg Thieme Verlag KG Stuttgart · New York.

Investigation into the propagation of Omega very low frequency signals and techniques for improvement of navigation accuracy including differential and composite omega

NASA Technical Reports Server (NTRS)

1973-01-01

An analysis of Very Low Frequency propagation in the atmosphere in the 10-14 kHz range leads to a discussion of some of the more significant causes of phase perturbation. The method of generating sky-wave corrections to predict the Omega phase is discussed. Composite Omega is considered as a means of lane identification and of reducing Omega navigation error. A simple technique for generating trapezoidal model (T-model) phase prediction is presented and compared with the Navy predictions and actual phase measurements. The T-model prediction analysis illustrates the ability to account for the major phase shift created by the diurnal effects on the lower ionosphere. An analysis of the Navy sky-wave correction table is used to provide information about spatial and temporal correlation of phase correction relative to the differential mode of operation.

A far-wing line shape theory which satisfies the detailed balance principle

NASA Technical Reports Server (NTRS)

Ma, Q.; Tipping, R. H.; Hartmann, J.-M.; Boulet, C.

1995-01-01

A far-wing theory in which the validity of the detailed balance principle is maintained in each step of the derivation is presented. The role of the total density matrix including the initial correlations is analyzed rigorously. By factoring out the rapidly varying terms in the complex-time development operator in the interaction representation, better approximate expressions can be obtained. As a result, the spectral density can be expressed in terms of the line-coupling functions in which two coupled lines are arranged symmetrically and whose frequency detunings are omega - 1/2(omega(sub ji) + omega (sub j'i'). Using the approximate values omega - omega(sub ji) results in expressions that do not satisfy the detailed balance principle. However, this principle remains satisfied for the symmetrized spectral density in which not only the coupled lines are arranged symmetrically, but also the initial and final states belonging to the same lines are arranged symmetrically as well.

Not Simply a Matter of Fish Intake.

PubMed

Scherr, Carlos; Figueiredo, Valeria N; Moura, Filipe A; Sposito, Andrei C

2015-01-01

Recent findings have highlighted enhanced fish consumption as a potential measure to increase intake of healthy fatty acids, particularly omega-3. The generalizability of this recommendation, however, may fall short of differences in fish species and cooking techniques. Hence, we investigated how these 2 variables affect the lipid content in fish flesh. Nine species of freshwater, deep sea or shore fish were grilled, steamed or fried with or without the addition of soybean oil, olive oil or butter. The lipid composition was analysed and a significant difference was observed in cholesterol, saturated fatty acids, polyunsaturated fatty acids, omega-3 fatty acids and omega-6 fatty acids contents between species (p<0.05). The use of soybean or olive oil was associated with a significant change in flesh concentration of polyunsaturated, omega-3 and omega-6 fatty acids (p<0.05). This study calls attention to the specific lipid content that must be expected from different fish species and cooking techniques.

Eccentricity and argument of perigee control for orbits with repeat ground tracks

NASA Technical Reports Server (NTRS)

Vincent, Mark A.

1992-01-01

In order to gain an understanding into the problem of eccentricity (e) and argument of perigee (omega) control for TOPEX/Poseidon, the two cases where the highest latitude crossing time and one of the equator crossings are held constant are investigated. Variations in e and omega cause a significant effect on the satellite's ground-track repeatability. Maintaining e and omega near their frozen values will minimize this variation. Analytical expressions are found to express this relationship while keeping an arbitrary point of the ground track fixed. The initial offset of the ground track from its nominal path determines the subsequent evolution of e and omega about their frozen values. This long-term behavior is numerically determined using an earth gravitational field including the first 17 zonal harmonics. The numerical results are plotted together with the analytical constraints to see if the later values of e and omega cause unacceptable deviation in the ground track.

Theoretical properties of Omega-loops in the convective zone of the Sun. 1: Emerging bipolar magnetic regions

NASA Technical Reports Server (NTRS)

Parker, E. N.

1994-01-01

It is proposed that the observed 500 G intensity of the magnetic fields emerging through the surface of the Sun can be understood from the Bernoulli effect in the upwelling Omega-loops of magnetic field. It is also proposed that the inferred 10(exp 5) G azimuthal flux bundles below the base of the convective zone can be understood as a consequence of the large-scale buoyancy associated with the upwelling fluid in and around the rising Omega-loop. The process fits in naturally with the Babcock-Leighton form of the solar alpha-omega-dynamo. The emerging Omega-loop implies the coherence of the upwelling all the way from the bottom of the convective zone, enhancing the convective heat transport to account for the observed variation of the solar irradiance by about two parts in 10(exp 3).

Omega-3 fatty acid supplementation in perinatal settings.

PubMed

Blanchard, Dawn S

2006-01-01

The purpose of this article is (a) to explain the role of omega-3 fatty acids in human health, specifically in fetal/neonatal development, (b) to summarize the recent research behind the innovations in infant formula manufacturing and advertisement of omega-3 fatty acid supplementation for pregnant and lactating mothers, and (c) to relate the research findings to clinical practice. Omega-3 fatty acid supplementation in perinatal settings is discussed here from three vantage points: (a) supplementation of the third-trimester pregnant woman to enhance fetal development, (b) supplementation of the lactating mother to enhance development of the breastfeeding infant, and (c) supplementation of infant formulas to enhance development of the bottle-feeding infant. Supplementation can occur by increasing one's intake of foods high in omega-3 fatty acids or by ingesting fatty acid nutritional supplements. The challenge of supplementation for vegan and vegetarian women is also addressed.

Hangout with CERN: a direct conversation with the public

NASA Astrophysics Data System (ADS)

Rao, Achintya; Goldfarb, Steven; Kahle, Kate

2016-04-01

Hangout with CERN refers to a weekly, half-hour-long, topical webcast hosted at CERN. The aim of the programme is threefold: (i) to provide a virtual tour of various locations and facilities at CERN, (ii) to discuss the latest scientific results from the laboratory, and, most importantly, (iii) to engage in conversation with the public and answer their questions. For each ;episode;, scientists gather around webcam-enabled computers at CERN and partner institutes/universities, connecting to one another using the Google+ social network's ;Hangouts; tool. The show is structured as a conversation mediated by a host, usually a scientist, and viewers can ask questions to the experts in real time through a Twitter hashtag or YouTube comments. The history of Hangout with CERN can be traced back to ICHEP 2012, where several physicists crowded in front of a laptop connected to Google+, using a ;Hangout On Air; webcast to explain to the world the importance of the discovery of the Higgs-like boson, announced just two days before at the same conference. Hangout with CERN has also drawn inspiration from two existing outreach endeavours: (i) ATLAS Virtual Visits, which connected remote visitors with scientists in the ATLAS Control Room via video conference, and (ii) the Large Hangout Collider, in which CMS scientists gave underground tours via Hangouts to groups of schools and members of the public around the world. In this paper, we discuss the role of Hangout with CERN as a bi-directional outreach medium and an opportunity to train scientists in effective communication.

CERN Winter School on Supergravity, Strings, and Gauge Theory 2010

ScienceCinema

None

2018-05-15

The CERN Winter School on Supergravity, Strings, and Gauge Theory is the analytic continuation of the yearly training school of the former EC-RTN string network Constituents, Fundamental Forces and Symmetries of the Universe. The 2010 edition of the school is supported and organized by the CERN Theory Divison, and will take place from Monday January 25 to Friday January 29, at CERN. As its predecessors, this school is meant primarily for training of doctoral students and young postdoctoral researchers in recent developments in theoretical high-energy physics and string theory. The programme of the school will consist of five series of pedagogical lectures, complemented by tutorial discussion sessions in the afternoons. Previous schools in this series were organized in 2005 at SISSA in Trieste, and in 2006, 2007, 2008, and 2009 at CERN, Geneva.

Total dietary fat and omega-3 fatty acids have modest effects on urinary sex hormones in postmenopausal women

USDA-ARS?s Scientific Manuscript database

Total fat and omega-3 fatty acids in the diet may affect breast cancer risk by altering estrogen metabolism. The purpose of this study was to elucidate the effects of differing total fat and omega-3 fatty acid content of diets on a panel of urinary estrogens and metabolites. A controlled, cross-ove...

On a theorem of existence for scaling problems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Osmolovskii, V.G.

1995-12-05

The authors study the question of the existence of the global minimum of the functional over the set of functions where {Omega} {contained_in} R{sup n} is a bounded domain, and a fixed function K (x,y) = K (y,x) belongs to L{sub 2} ({Omega} x {Omega}). Such functionals arise in some mathematical models of economics and sociology.

Supernova Cosmology Project

Science.gov Websites

universe. PDF Top panel only of previous Hubble diagram Figure 6 PDF Figure 8 Confidence regions for Omega_Mass vs Omega_Lambda PDF Figure 8 with results from CMB and galaxy cluster data added. PDF Figure 12 Joint measurements of Omega_Mass and w assuming a flat universe and w constant in time. PDF These slides

40 CFR 721.10408 - Poly[oxy(methyl-1,2-ethanediyl)], .alpha.-[2-[[2,2-dimethyl-3-[(1-oxododecyl) oxy]propylidene...

Code of Federal Regulations, 2013 CFR

2013-07-01

...)], .alpha.-[2-[[2,2-dimethyl-3-[(1-oxododecyl) oxy]propylidene] amino] methylethyl]-.omega.-[2-[[2,2...-ethanediyl)], .alpha.-[2-[[2,2-dimethyl-3-[(1-oxododecyl) oxy]propylidene] amino] methylethyl]-.omega.-[2-[[2...-ethanediyl)], .alpha.-[2-[[2,2-dimethyl-3-[(1-oxododecyl)oxy]propylidene] amino] methylethyl]-.omega.-[2-[[2...

Omega-3 Fatty Acid Supplementation for the Treatment of Children with Attention-Deficit/Hyperactivity Disorder Symptomatology: Systematic Review and Meta-Analysis

ERIC Educational Resources Information Center

Bloch, Michael H.; Qawasmi, Ahmad

2011-01-01

Objective: Several studies have demonstrated differences in omega-3 fatty acid composition in plasma and in erythrocyte membranes in patients with attention-deficit/hyperactivity disorder (ADHD) compared with unaffected controls. Omega-3 fatty acids have anti-inflammatory properties and can alter central nervous system cell membrane fluidity and…

40 CFR 721.10408 - Poly[oxy(methyl-1,2-ethanediyl)], .alpha.-[2-[[2,2-dimethyl-3-[(1-oxododecyl) oxy]propylidene...

Code of Federal Regulations, 2014 CFR

2014-07-01

...)], .alpha.-[2-[[2,2-dimethyl-3-[(1-oxododecyl) oxy]propylidene] amino] methylethyl]-.omega.-[2-[[2,2...-ethanediyl)], .alpha.-[2-[[2,2-dimethyl-3-[(1-oxododecyl) oxy]propylidene] amino] methylethyl]-.omega.-[2-[[2...-ethanediyl)], .alpha.-[2-[[2,2-dimethyl-3-[(1-oxododecyl)oxy]propylidene] amino] methylethyl]-.omega.-[2-[[2...

40 CFR 721.10408 - Poly[oxy(methyl-1,2-ethanediyl)], .alpha.-[2-[[2,2-dimethyl-3-[(1-oxododecyl) oxy]propylidene...

Code of Federal Regulations, 2012 CFR

2012-07-01

...)], .alpha.-[2-[[2,2-dimethyl-3-[(1-oxododecyl) oxy]propylidene] amino] methylethyl]-.omega.-[2-[[2,2...-ethanediyl)], .alpha.-[2-[[2,2-dimethyl-3-[(1-oxododecyl) oxy]propylidene] amino] methylethyl]-.omega.-[2-[[2...-ethanediyl)], .alpha.-[2-[[2,2-dimethyl-3-[(1-oxododecyl)oxy]propylidene] amino] methylethyl]-.omega.-[2-[[2...

Oleic Acid: Natural variation and potential enhancement in oilseed crops.

USDA-ARS?s Scientific Manuscript database

Oleic acid is a monounsaturated omega 9 fatty acid (MUFA, C18:1) which can be found in various plant lipids and animal fats. Unlike omega 3 (a-linolenic acid, C18:3) and omega 6 (linoleic acid, C18:2) fatty acids which are essential because they cannot be synthesized by humans and must be obtained f...

Physical explanations of the destabilizing effect of damping in rotating parts

NASA Technical Reports Server (NTRS)

Crandall, S. H.

1980-01-01

The destabilizing effect of rotating damping was investigated. When the rotation was faster than the whirl, rotating damping drags the orbiting particle forward. When stationary damping was also present, the stability borderline was readily determined by balancing the backward and forward drags. A key notion was that a forward whirl at rate omega a sub n with respect to stationary axes appears to be a backward whirl at rate Omega - omega sub n with respect to a system rotating supercritically at rate Omega. The growth rate of unstable whirls (or the decay rate of stable whirls was readily estimated by a simple energy balance.

Demonstration of high-energy 2 omega (526.5 nm) operation on the National Ignition Facility Laser System.

PubMed

Heestand, G M; Haynam, C A; Wegner, P J; Bowers, M W; Dixit, S N; Erbert, G V; Henesian, M A; Hermann, M R; Jancaitis, K S; Knittel, K; Kohut, T; Lindl, J D; Manes, K R; Marshall, C D; Mehta, N C; Menapace, J; Moses, E; Murray, J R; Nostrand, M C; Orth, C D; Patterson, R; Sacks, R A; Saunders, R; Shaw, M J; Spaeth, M; Sutton, S B; Williams, W H; Widmayer, C C; White, R K; Whitman, P K; Yang, S T; Van Wonterghem, B M

2008-07-01

A single beamline of the National Ignition Facility (NIF) has been operated at a wavelength of 526.5 nm (2 omega) by frequency converting the fundamental 1053 nm (1 omega) wavelength with an 18.2 mm thick type-I potassium dihydrogen phosphate (KDP) second-harmonic generator (SHG) crystal. Second-harmonic energies of up to 17.9 kJ were measured at the final optics focal plane with a conversion efficiency of 82%. For a similarly configured 192-beam NIF, this scales to a total 2 omega energy of 3.4 MJ full NIF equivalent (FNE).

Computation of Turbulent Heat Transfer on the Walls of a 180 Degree Turn Channel With a Low Reynolds Number Reynolds Stress Model

NASA Technical Reports Server (NTRS)

Ameri, A. A.; Rigby, D. L.; Steinthorsson, E.; Gaugler, Raymond (Technical Monitor)

2002-01-01

The Low Reynolds number version of the Stress-omega model and the two equation k-omega model of Wilcox were used for the calculation of turbulent heat transfer in a 180 degree turn simulating an internal coolant passage. The Stress-omega model was chosen for its robustness. The turbulent thermal fluxes were calculated by modifying and using the Generalized Gradient Diffusion Hypothesis. The results showed that using this Reynolds Stress model allowed better prediction of heat transfer compared to the k-omega two equation model. This improvement however required a finer grid and commensurately more CPU time.

PNPLA1 Deficiency in Mice and Humans Leads to a Defect in the Synthesis of Omega-O-Acylceramides

PubMed Central

Grond, Susanne; Eichmann, Thomas O.; Dubrac, Sandrine; Kolb, Dagmar; Schmuth, Matthias; Fischer, Judith; Crumrine, Debra; Elias, Peter M.; Haemmerle, Guenter; Zechner, Rudolf; Lass, Achim; Radner, Franz P.W.

2017-01-01

Mutations in PNPLA1 have been identified as causative for autosomal recessive congenital ichthyosis in humans and dogs. So far, the underlying molecular mechanisms are unknown. In this study, we generated and characterized PNPLA1-deficient mice and found that PNPLA1 is crucial for epidermal sphingolipid synthesis. The absence of functional PNPLA1 in mice impaired the formation of omega-O-acylceramides and led to an accumulation of nonesterified omega-hydroxy-ceramides. As a consequence, PNPLA1-deficient mice lacked a functional corneocyte-bound lipid envelope leading to a severe skin barrier defect and premature death of newborn animals. Functional analyses of differentiated keratinocytes from a patient with mutated PNPLA1 demonstrated an identical defect in omega-O-acylceramide synthesis in human cells, indicating that PNPLA1 function is conserved among mammals and indispensable for normal skin physiology. Notably, topical application of epidermal lipids from wild-type onto Pnpla1-mutant mice promoted rebuilding of the corneocyte-bound lipid envelope, indicating that supplementation of ichthyotic skin with omega-O-acylceramides might be a therapeutic approach for the treatment of skin symptoms in individuals affected by omega-O-acylceramide deficiency. PMID:27751867

Evidence that norflurazon affects chloroplast lipid unsaturation in soybean leaves (Glycine max L.).

PubMed

Abrous-Belbachir, Ouzna; De Paepe, Rosine; Trémolières, Antoine; Mathieu, Chantal; Ad, Fatiha; Benhassaine-Kesri, Ghouziel

2009-12-09

Norflurazon is a bleaching herbicide known to block carotenoid biosynthesis by inhibiting phytoene desaturase activity. Soybean plants were treated with norflurazon, and we examined the effects on the desaturation of lipid molecular species in leaves using ammonium [1-(14)C] oleate labeling. In monogalactosyldiacylglycerol (MGDG), the main chloroplast lipid, a decrease in 18:3/18:3 molecular species and an increase in its precursors 18:2/18:3 and 18:2/18:2 were observed suggesting that the omega(3) FAD7 desaturase activity in planta was inhibited by norflurazon. The in vitro activity of MGDG synthase was also inhibited by 69%. In contrast, the amount of 18:3/18:3 molecular species of phosphatidylcholine (PC) in the extraplastid compartment increased. The observed increase in in vitro lysoPC-acyltransferase activity and activation of desaturation of [1-(14)C] oleate suggest that extraplastid omega(3)FAD3 desaturase was activated. Analysis of the expression of omega(3) FAD3 and omega(3) FAD7 genes in norflurazon treated plants indicate that omega(3) FAD7 and omega(3) FAD3 desaturases are controlled at the post-transcriptional level.

Bioengineered Plants Can Be a Useful Source of Omega-3 Fatty Acids

PubMed Central

Lyu, Shan-Wu

2017-01-01

Omega-3 fatty acids have proven to be very essential for human health due to their multiple health benefits. These essential fatty acids (EFAs) need to be uptaken through diet because they are unable to be produced by the human body. These are important for skin and hair growth as well as for proper visual, neural, and reproductive functions of the body. These fatty acids are proven to be extremely vital for normal tissue development during pregnancy and infancy. Omega-3 fatty acids can be obtained mainly from two dietary sources: marine and plant oils. Eicosapentaenoic acid (EPA; C20:5 n-3) and docosahexaenoic acid (DHA; C22:6 n-3) are the primary marine-derived omega-3 fatty acids. Marine fishes are high in omega-3 fatty acids, yet high consumption of those fishes will cause a shortage of fish stocks existing naturally in the oceans. An alternative source to achieve the recommended daily intake of EFAs is the demand of today. In this review article, an attempt has, therefore, been made to discuss the importance of omega-3 fatty acids and the recent developments in order to produce these fatty acids by the genetic modifications of the plants. PMID:28316988

Bioengineered Plants Can Be a Useful Source of Omega-3 Fatty Acids.

PubMed

Amjad Khan, Waleed; Chun-Mei, Hu; Khan, Nadeem; Iqbal, Amjad; Lyu, Shan-Wu; Shah, Farooq

2017-01-01

Omega-3 fatty acids have proven to be very essential for human health due to their multiple health benefits. These essential fatty acids (EFAs) need to be uptaken through diet because they are unable to be produced by the human body. These are important for skin and hair growth as well as for proper visual, neural, and reproductive functions of the body. These fatty acids are proven to be extremely vital for normal tissue development during pregnancy and infancy. Omega-3 fatty acids can be obtained mainly from two dietary sources: marine and plant oils. Eicosapentaenoic acid (EPA; C20:5 n-3) and docosahexaenoic acid (DHA; C22:6 n-3) are the primary marine-derived omega-3 fatty acids. Marine fishes are high in omega-3 fatty acids, yet high consumption of those fishes will cause a shortage of fish stocks existing naturally in the oceans. An alternative source to achieve the recommended daily intake of EFAs is the demand of today. In this review article, an attempt has, therefore, been made to discuss the importance of omega-3 fatty acids and the recent developments in order to produce these fatty acids by the genetic modifications of the plants.

Understanding diet and modeling changes in the omega-3 and omega-6 fatty acid composition of U.S. garrison foods for active duty personnel.

PubMed

Marriott, Bernadette P; Yu, Karina; Majchrzak-Hong, Sharon; Johnson, Jeremiah; Hibbeln, Joseph R

2014-11-01

Research indicates that dietary omega-3 and omega-6 polyunsaturated fatty acids (PUFAs) are important in reducing the risk of mental illness. We used the DoD Survey of Health Related Behaviors among Active Duty Military Personnel (HRBS) to assess current military dietary patterns and meal locations. We used the Lands Equation to model PUFAs in a sample Garrison diet and the nutritional impact of substitution of foods higher in omega-3 PUFAs and lower in omega-6 PUFAs on tissue composition. The military diet was very poor quality compared to 2010 Healthy People Guidelines. A representative Garrison diet does not meet our estimated healthy n-3 HUFA intake at 3.5 g/d, corresponding with a tissue composition of 60% n-3 in HUFA (i.e., 40% n-6 in HUFA). Substitution of n-3 rich eggs, poultry, pork and other food commodities, combined with use on low linoleic acid oils, may contribute significantly to attaining healthier n-6/n-3 proportions in the tissue. Reprint & Copyright © 2014 Association of Military Surgeons of the U.S.

Exploration of the perceived and actual benefits of omega-3 fatty acids and the impact of FADS1 and FADS2 genetic information on dietary intake and blood levels of EPA and DHA.

PubMed

Roke, Kaitlin

2017-03-01

From a global health perspective, increased intake of omega-3 fatty acids (FAs), in particular eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are beneficial for human health. However, the consumption of EPA- and DHA-rich foods such as fatty fish is low in the Western diet. Therefore, finding new ways to motivate people to increase their consumption of omega-3 FAs is essential. To find effective ways to motivate individuals, understanding people's awareness of omega-3 FAs and how they obtain their knowledge about nutrition and health is critical. Consequently, we developed an online survey to assess awareness and self-reported intake of omega-3 FAs and supplements in young adults. EPA and DHA are also produced endogenously to a limited extent through a pathway regulated by fatty acid desaturase 1 and 2 (FADS1 and FADS2) genes. Of relevance, single nucleotide polymorphisms (SNPs) in the FADS genes influence levels of omega-3 FAs, where minor allele carriers have lower levels compared with major allele carriers. Accordingly, we conducted a clinical trial to investigate FA levels in response to dietary EPA and DHA supplementation in young adults stratified by SNPs in FADS1 and FADS2. The level of reported awareness of omega-3 terminology varied depending on an individual's field of study and thus providing all participants with the same set of nutrition information could be an effective tool to increase knowledge and motivate behaviour change. Additionally, the variation in FA levels in accordance to SNPs in FADS1 and FADS2 could be used to create tailored nutritional recommendations which may improve lifestyle habits. The results discovered in the first 2 studies regarding awareness of omega-3 FAs and genetic variation were subsequently used to design a nutrigenetics intervention in young adults. Individuals who received their FADS1 genetic information were more aware of different omega-3 FAs and reported fewer barriers to their consumption by the end of the study, compared with those who did not receive their personal genetic information. All participants increased their intake of EPA and DHA, which was reflected in the analyses of red blood cells. Overall, this thesis demonstrates the power of combining nutritional and genetic information as motivators to increase omega-3 consumption.

The time course of erythrocyte membrane fatty acid concentrations during and after treatment of non-human primates with increasing doses of an omega-3 rich phospholipid preparation derived from krill-oil.

PubMed

Hals, Petter-Arnt; Wang, Xiaoli; Piscitelli, Fabiana; Di Marzo, Vincenzo; Xiao, Yong-Fu

2017-01-21

A commonly used measure to reflect the intake of the long-chain omega-3 fatty acids EPA and DHA is the omega-3 index, defined as the sum of EPA + DHA as % of total fatty acids in erythrocyte membrane. When the omega-3 index changes it follows that the relative fractions of other fatty acids in the membrane are also changed. In the present study, increasing doses of a preparation of omega-3 rich phospholipids extracted from krill oil were administered orally to non-human primates for 12 weeks and the time course of EPA, DHA and 22 other fatty acids in erythrocytes was determined bi-weekly during treatment and for 8 weeks after cessation of treatment. Plasma concentrations of six endocannabinoid-type mediators being downstream metabolites of some fatty acids analyzed in erythrocytes were also determined. Six diabetic, dyslipidemic non-human primates were included, three in a vehicle control group and three being treated with the omega-3 rich phospholipid preparation. The vehicle control and test items were given daily by gavage and the test item doses were 50, 150 and 450 mg phospholipids/kg/day. Each dose level was given for four weeks. Blood was sampled at baseline and thereafter bi-weekly. Fatty acids were determined in erythrocytes by methylation followed by gas-chromatography. Endocannabinoids and endocannabinoid-like mediators were analyzed in plasma by liquid chromatography-atmospheric pressure chemical ionization-mass spectrometry. The treatment resulted in a dose-related increase in the fraction of EPA and DHA in erythrocyte membranes and a dose-related decrease of other poly-unsaturated fatty acids, in particular omega-6 polyunsaturated fatty acids. Erythrocyte concentrations of saturated fatty acids remained unchanged throughout the experiment. Plasma concentrations of endocannabinoids and endocannabinoid-like mediators changed accordingly as those being downstream arachidonic acid decreased, downstream of the saturated palmitic and oleic acids remained unchanged while a downstream EPA metabolite increased. Increasing the omega-3 index by administering an omega-3 rich phospholipid extracted from krill oil did not alter the ratio of unsaturated vs. saturated fatty acids in the erythrocyte membranes but only the relative concentrations of unsaturated fatty acids, in particular unsaturated omega-6 fatty acids. Concentrations of saturated fatty acids remained unchanged.

Convective instabilities of electromagnetic ion cyclotron waves in the outer magnetosphere

NASA Technical Reports Server (NTRS)

Horne, Richard B.; Thorne, Richard M.

1994-01-01

The path-integrated linear growth of electromagnetic ion cyclotron waves in the outer (L is greater than or equal to 7) magnetosphere is investigated using a realistic thermal plasma distribution with an additional anisotropic energetic ring current H(+) to provide free energy for instability. The results provide a realistic simulation of the recent Active Magneto- spheric Particle Tracer Explorers (AMPTE) observations. For conditions typical of the dayside magnetosphere, high plasma beta effects reduce the group velocity and significantly increase the spatial growth rates for left-handed polarized instabilities just below the helium gyrofrequency Omega(sub He(+)), and on the guided mode above Omega(sub He(+)) but below the cross over frequency omega(sub cr). Relatively high densities, typical of the afternoon local time sector, favor these low group velocity effects for predominantly field-aligned waves. Lower densities, typical of those found in the early morning local time sector, increase the group velocity but allow strong convective instabilities at high normalized frequencies well above Omega(sub He(+)). These waves are reflected in the magnetosphere and can exist for several equatorial transits without significant damping. They are left-handed polarized only on the first equatorial crossing and become linearly polarized for the remainder of the ray path. Consequently, these waves should be observed with basically linear polarization at all frequencies and all latitudes in the early morning local time sector. Wave growth below Omega(sub He(+)) is severely limited owing to the narrow bandwidth for instability and the small resonant path lengths. In the afternoon sector, where plasma densities can exceed 10(exp 7)/cu m, intense convective amplification is possible both above and below Omega(sub He(+)). Waves below Omega(sub He(+)) are not subject to reflection when the O(+) concentration is small and therefore should be observed with left-handed polarization near the equator and essentially linear polarization at higher latitudes. Since the He(+) concentration is usually large in the afternoon sector, guided mode waves above Omega(sub He(+)) reflect to form a background distribution with basically linear polarization. We suggest that the strong left-handed polarized emissions observed by AMPTE in the afternoon sector near the equator are probably due to strongly growing low group velocity waves at frequencies just below Omega(sub He(+)), and on the guided mode above Omega(sub He(+)).

PREFACE: International Conference on Computing in High Energy and Nuclear Physics (CHEP 2010)

NASA Astrophysics Data System (ADS)

Lin, Simon C.; Shen, Stella; Neufeld, Niko; Gutsche, Oliver; Cattaneo, Marco; Fisk, Ian; Panzer-Steindel, Bernd; Di Meglio, Alberto; Lokajicek, Milos

2011-12-01

The International Conference on Computing in High Energy and Nuclear Physics (CHEP) was held at Academia Sinica in Taipei from 18-22 October 2010. CHEP is a major series of international conferences for physicists and computing professionals from the worldwide High Energy and Nuclear Physics community, Computer Science, and Information Technology. The CHEP conference provides an international forum to exchange information on computing progress and needs for the community, and to review recent, ongoing and future activities. CHEP conferences are held at roughly 18 month intervals, alternating between Europe, Asia, America and other parts of the world. Recent CHEP conferences have been held in Prauge, Czech Republic (2009); Victoria, Canada (2007); Mumbai, India (2006); Interlaken, Switzerland (2004); San Diego, California(2003); Beijing, China (2001); Padova, Italy (2000) CHEP 2010 was organized by Academia Sinica Grid Computing Centre. There was an International Advisory Committee (IAC) setting the overall themes of the conference, a Programme Committee (PC) responsible for the content, as well as Conference Secretariat responsible for the conference infrastructure. There were over 500 attendees with a program that included plenary sessions of invited speakers, a number of parallel sessions comprising around 260 oral and 200 poster presentations, and industrial exhibitions. We thank all the presenters, for the excellent scientific content of their contributions to the conference. Conference tracks covered topics on Online Computing, Event Processing, Software Engineering, Data Stores, and Databases, Distributed Processing and Analysis, Computing Fabrics and Networking Technologies, Grid and Cloud Middleware, and Collaborative Tools. The conference included excursions to various attractions in Northern Taiwan, including Sanhsia Tsu Shih Temple, Yingko, Chiufen Village, the Northeast Coast National Scenic Area, Keelung, Yehliu Geopark, and Wulai Aboriginal Village, as well as two banquets held at the Grand Hotel and Grand Formosa Regent in Taipei. The next CHEP conference will be held in New York, the United States on 21-25 May 2012. We would like to thank the National Science Council of Taiwan, the EU ACEOLE project, commercial sponsors, and the International Advisory Committee and the Programme Committee members for all their support and help. Special thanks to the Programme Committee members for their careful choice of conference contributions and enormous effort in reviewing and editing about 340 post conference proceedings papers. Simon C Lin CHEP 2010 Conference Chair and Proceedings Editor Taipei, Taiwan November 2011 Track Editors/ Programme Committee Chair Simon C Lin, Academia Sinica, Taiwan Online Computing Track Y H Chang, National Central University, Taiwan Harry Cheung, Fermilab, USA Niko Neufeld, CERN, Switzerland Event Processing Track Fabio Cossutti, INFN Trieste, Italy Oliver Gutsche, Fermilab, USA Ryosuke Itoh, KEK, Japan Software Engineering, Data Stores, and Databases Track Marco Cattaneo, CERN, Switzerland Gang Chen, Chinese Academy of Sciences, China Stefan Roiser, CERN, Switzerland Distributed Processing and Analysis Track Kai-Feng Chen, National Taiwan University, Taiwan Ulrik Egede, Imperial College London, UK Ian Fisk, Fermilab, USA Fons Rademakers, CERN, Switzerland Torre Wenaus, BNL, USA Computing Fabrics and Networking Technologies Track Harvey Newman, Caltech, USA Bernd Panzer-Steindel, CERN, Switzerland Antonio Wong, BNL, USA Ian Fisk, Fermilab, USA Niko Neufeld, CERN, Switzerland Grid and Cloud Middleware Track Alberto Di Meglio, CERN, Switzerland Markus Schulz, CERN, Switzerland Collaborative Tools Track Joao Correia Fernandes, CERN, Switzerland Philippe Galvez, Caltech, USA Milos Lokajicek, FZU Prague, Czech Republic International Advisory Committee Chair: Simon C. Lin , Academia Sinica, Taiwan Members: Mohammad Al-Turany , FAIR, Germany Sunanda Banerjee, Fermilab, USA Dario Barberis, CERN & Genoa University/INFN, Switzerland Lothar Bauerdick, Fermilab, USA Ian Bird, CERN, Switzerland Amber Boehnlein, US Department of Energy, USA Kors Bos, CERN, Switzerland Federico Carminati, CERN, Switzerland Philippe Charpentier, CERN, Switzerland Gang Chen, Institute of High Energy Physics, China Peter Clarke, University of Edinburgh, UK Michael Ernst, Brookhaven National Laboratory, USA David Foster, CERN, Switzerland Merino Gonzalo, CIEMAT, Spain John Gordon, STFC-RAL, UK Volker Guelzow, Deutsches Elektronen-Synchrotron DESY, Hamburg, Germany John Harvey, CERN, Switzerland Frederic Hemmer, CERN, Switzerland Hafeez Hoorani, NCP, Pakistan Viatcheslav Ilyin, Moscow State University, Russia Matthias Kasemann, DESY, Germany Nobuhiko Katayama, KEK, Japan Milos Lokajícek, FZU Prague, Czech Republic David Malon, ANL, USA Pere Mato Vila, CERN, Switzerland Mirco Mazzucato, INFN CNAF, Italy Richard Mount, SLAC, USA Harvey Newman, Caltech, USA Mitsuaki Nozaki, KEK, Japan Farid Ould-Saada, University of Oslo, Norway Ruth Pordes, Fermilab, USA Hiroshi Sakamoto, The University of Tokyo, Japan Alberto Santoro, UERJ, Brazil Jim Shank, Boston University, USA Alan Silverman, CERN, Switzerland Randy Sobie , University of Victoria, Canada Dongchul Son, Kyungpook National University, South Korea Reda Tafirout , TRIUMF, Canada Victoria White, Fermilab, USA Guy Wormser, LAL, France Frank Wuerthwein, UCSD, USA Charles Young, SLAC, USA

CERN@school: bringing CERN into the classroom

NASA Astrophysics Data System (ADS)

Whyntie, T.; Cook, J.; Coupe, A.; Fickling, R. L.; Parker, B.; Shearer, N.

2016-04-01

CERN@school brings technology from CERN into the classroom to aid with the teaching of particle physics. It also aims to inspire the next generation of physicists and engineers by giving participants the opportunity to be part of a national collaboration of students, teachers and academics, analysing data obtained from detectors based on the ground and in space to make new, curiosity-driven discoveries at school. CERN@school is based around the Timepix hybrid silicon pixel detector developed by the Medipix 2 Collaboration, which features a 300 μm thick silicon sensor bump-bonded to a Timepix readout ASIC. This defines a 256-by-256 grid of pixels with a pitch of 55 μm, the data from which can be used to visualise ionising radiation in a very accessible way. Broadly speaking, CERN@school consists of a web portal that allows access to data collected by the Langton Ultimate Cosmic ray Intensity Detector (LUCID) experiment in space and the student-operated Timepix detectors on the ground; a number of Timepix detector kits for ground-based experiments, to be made available to schools for both teaching and research purposes; and educational resources for teachers to use with LUCID data and detector kits in the classroom. By providing access to cutting-edge research equipment, raw data from ground and space-based experiments, CERN@school hopes to provide the foundation for a programme that meets the many of the aims and objectives of CERN and the project's supporting academic and industrial partners. The work presented here provides an update on the status of the programme as supported by the UK Science and Technology Facilities Council (STFC) and the Royal Commission for the Exhibition of 1851. This includes recent results from work with the GridPP Collaboration on using grid resources with schools to run GEANT4 simulations of CERN@school experiments.

[Food sources and adequacy of intake of omega 3 and omega-6 fatty acids in a representative sample of Spanish adults].

PubMed

Ortega Anta, Rosa M; González Rodríguez, Liliana G; Villalobos Cruz, Tania K; Perea Sánchez, José Miguel; Aparicio Vizuete, Aránzazu; López Sobaler, Ana María

2013-11-01

Taking into account the sanitary importance of the contribution of omega 3 and omega 6 fatty acids and given the scarcity of studies on the subject in Spanish collectives, the aims of the present study were to determine the intake of these fatty acids, their adequacy to the established nutritional goals and food sources in a representative sample of the Spanish population. A group of 1,068 adults (521 men and 547 women) with ages ranging from 17 and 60 years were studied. The subjects were selected from ten Spanish provinces to constitute a representative sample of the nationwide population. The intakes of polyunsaturated fatty acids (PUFA), omega-3 fatty acids, α-linolenic acid (ALA), eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), omega-6 fatty acids, linoleic acid (LA) and arachidonic acid, expressed in g/day and percentage of the total energy intake, were determined by using a food record for 3 consecutive days, including a Sunday. Personal, anthropometric and sanitary data of individuals were also studied. The intake of total fat and saturated fat was higher than the established as advisable in 89.2% and 93.3% of the studied subjects, respectively. The opposite was observed for the intake of PUFA, where an insufficient contribution was most frequent (79.2% of the subjects have an intake less than the 6% of the energy). The contribution of omega-3 fatty acids (1.85±0.82 g/day) is particularly low, and provides less than 1% of the energy in 85.3% of subjects. Specifically the ALA (1.40±0.55 g/day) did not exceed the 0.5% of energy in 53.7% of the cases, and the EPA + DHA (0.55±0.58 g/day) did not exceed 0.5 g/day in 64.6%. On the other hand, the contribution of omega-6 was more appropriate (10.95±3.79 g/day), specifically for LA intake (10.77±3.76 g/day), representing less than 3% of the energy in the 25.5 % of subjects. The main food sources for omega-3 were fish, followed by meat, dairy and fats/oils, whereas for omega-6 were fats/oils, meat and cereals. Taking into account that the low consumption of omega-3 fatty acids is noteworthy in the studied group, especially for EPA + DHA, the influence of the fish consumption is important, since people who consume less than 0.5 servings/day (29.8%) have intakes of omega-3 (1.46±0.57 g/day) and EPA + DHA (0.19±0.19 g/day) significantly lower than individuals with a higher consumption of fish (which have intakes of omega-3 and EPA + DHA of 2.02±0.85 g/day and 0.70±0.61 g/day, respectively) (p < 0.001). The increase in fish consumption facilitates meeting the nutritional goals set for omega-3 (≥ 1% of energy) (OR 0.371, 95% CI 0.306-0.451, p < 0.001) and for EPA + DHA (> 0.5 g/day) (OR 0.121, 95% CI 0.092-0.158, p < 0.001). Due to the high percentage of individuals who do not meet the nutritional goals set for omega-3, ALA, EPA and DHA, it would be advisable to increase the consumption of fish and/or foods enriched with these fatty acids in order to obtain nutritional and health benefits. Copyright AULA MEDICA EDICIONES 2013. Published by AULA MEDICA. All rights reserved.

News Conference: Serbia hosts teachers' seminar Resources: Teachers TV website closes for business Festival: Science takes to the stage in Denmark Research: How noise affects learning in secondary schools CERN: CERN visit inspires new teaching ideas Education: PLS aims to improve perception of science for school students Conference: Scientix conference discusses challenges in science education

NASA Astrophysics Data System (ADS)

2011-07-01

Conference: Serbia hosts teachers' seminar Resources: Teachers TV website closes for business Festival: Science takes to the stage in Denmark Research: How noise affects learning in secondary schools CERN: CERN visit inspires new teaching ideas Education: PLS aims to improve perception of science for school students Conference: Scientix conference discusses challenges in science education

News Particle Physics: ATLAS unveils mural at CERN Prize: Corti Trust invites essay entries Astrophysics: CERN holds cosmic-ray conference Researchers in Residence: Lord Winston returns to school Music: ATLAS scientists record physics music Conference: Champagne flows at Reims event Competition: Students triumph at physics olympiad Teaching: Physics proves popular in Japanese schools Forthcoming Events

NASA Astrophysics Data System (ADS)

2011-01-01

Particle Physics: ATLAS unveils mural at CERN Prize: Corti Trust invites essay entries Astrophysics: CERN holds cosmic-ray conference Researchers in Residence: Lord Winston returns to school Music: ATLAS scientists record physics music Conference: Champagne flows at Reims event Competition: Students triumph at physics olympiad Teaching: Physics proves popular in Japanese schools Forthcoming Events

Signature CERN-URSS

ScienceCinema

None

2017-12-09

Le DG W.Jentschke souhaite la bienvenue à l'assemblée et aux invités pour la signature du protocole entre le Cern et l'URSS qui est un événement important. C'est en 1955 que 55 visiteurs soviétiques ont visité le Cern pour la première fois. Le premier DG au Cern, F.Bloch, et Mons.Amaldi sont aussi présents. Tandis que le discours anglais de W.Jentschke est traduit en russe, le discours russe de Mons.Morozov est traduit en anglais.

The reliability of multidimensional neuropsychological measures: from alpha to omega.

PubMed

Watkins, Marley W

To demonstrate that Coefficient omega, a model-based estimate, is more a more appropriate index of reliability than coefficient alpha for the multidimensional scales that are commonly employed by neuropsychologists. As an illustration, a structural model of an overarching general factor and four first-order factors for the WAIS-IV based on the standardization sample of 2200 participants was identified and omega coefficients were subsequently computed for WAIS-IV composite scores. Alpha coefficients were ≥ .90 and omega coefficients ranged from .75 to .88 for WAIS-IV factor index scores, indicating that the blend of general and group factor variance in each index score created a reliable multidimensional composite. However, the amalgam of variance from general and group factors did not allow the precision of Full Scale IQ (FSIQ) and factor index scores to be disentangled. In contrast, omega hierarchical coefficients were low for all four factor index scores (.10-.41), indicating that most of the reliable variance of each factor index score was due to the general intelligence factor. In contrast, the omega hierarchical coefficient for the FSIQ score was .84. Meaningful interpretation of WAIS-IV factor index scores as unambiguous indicators of group factors is imprecise, thereby fostering unreliable identification of neurocognitive strengths and weaknesses, whereas the WAIS-IV FSIQ score can be interpreted as a reliable measure of general intelligence. It was concluded that neuropsychologists should base their clinical decisions on reliable scores as indexed by coefficient omega.