A Path to Discovery

ERIC Educational Resources Information Center

Stegemoller, William; Stegemoller, Rebecca

2004-01-01

The path taken and the turns made as a turtle traces a polygon are examined to discover an important theorem in geometry. A unique tool, the Angle Adder, is implemented in the investigation. (Contains 9 figures.)

Paths of Discovery: Comparing the Search Effectiveness of EBSCO Discovery Service, Summon, Google Scholar, and Conventional Library Resources

ERIC Educational Resources Information Center

Asher, Andrew D.; Duke, Lynda M.; Wilson, Suzanne

2013-01-01

In 2011, researchers at Bucknell University and Illinois Wesleyan University compared the search efficacy of Serial Solutions Summon, EBSCO Discovery Service, Google Scholar, and conventional library databases. Using a mixed-methods approach, qualitative and quantitative data were gathered on students' usage of these tools. Regardless of the…

An Adaptive Jitter Mechanism for Reactive Route Discovery in Sensor Networks

PubMed Central

Cordero, Juan Antonio; Yi, Jiazi; Clausen, Thomas

2014-01-01

This paper analyses the impact of jitter when applied to route discovery in reactive (on-demand) routing protocols. In multi-hop non-synchronized wireless networks, jitter—a small, random variation in the timing of message emission—is commonly employed, as a means to avoid collisions of simultaneous transmissions by adjacent routers over the same channel. In a reactive routing protocol for sensor and ad hoc networks, jitter is recommended during the route discovery process, specifically, during the network-wide flooding of route request messages, in order to avoid collisions. Commonly, a simple uniform jitter is recommended. Alas, this is not without drawbacks: when applying uniform jitter to the route discovery process, an effect called delay inversion is observed. This paper, first, studies and quantifies this delay inversion effect. Second, this paper proposes an adaptive jitter mechanism, designed to alleviate the delay inversion effect and thereby to reduce the route discovery overhead and (ultimately) allow the routing protocol to find more optimal paths, as compared to uniform jitter. This paper presents both analytical and simulation studies, showing that the proposed adaptive jitter can effectively decrease the cost of route discovery and increase the path quality. PMID:25111238

42 CFR 495.368 - Combating fraud and abuse.

Code of Federal Regulations, 2010 CFR

2010-10-01

... (CONTINUED) STANDARDS AND CERTIFICATION STANDARDS FOR THE ELECTRONIC HEALTH RECORD TECHNOLOGY INCENTIVE... identified as an overpayment regardless of recoupment from such providers, within 60 days of discovery of the...

Receiver-Based Ad Hoc On Demand Multipath Routing Protocol for Mobile Ad Hoc Networks

PubMed Central

Al-Nahari, Abdulaziz; Mohamad, Mohd Murtadha

2016-01-01

Decreasing the route rediscovery time process in reactive routing protocols is challenging in mobile ad hoc networks. Links between nodes are continuously established and broken because of the characteristics of the network. Finding multiple routes to increase the reliability is also important but requires a fast update, especially in high traffic load and high mobility where paths can be broken as well. The sender node keeps re-establishing path discovery to find new paths, which makes for long time delay. In this paper we propose an improved multipath routing protocol, called Receiver-based ad hoc on demand multipath routing protocol (RB-AOMDV), which takes advantage of the reliability of the state of the art ad hoc on demand multipath distance vector (AOMDV) protocol with less re-established discovery time. The receiver node assumes the role of discovering paths when finding data packets that have not been received after a period of time. Simulation results show the delay and delivery ratio performances are improved compared with AOMDV. PMID:27258013

Receiver-Based Ad Hoc On Demand Multipath Routing Protocol for Mobile Ad Hoc Networks.

PubMed

Al-Nahari, Abdulaziz; Mohamad, Mohd Murtadha

2016-01-01

Decreasing the route rediscovery time process in reactive routing protocols is challenging in mobile ad hoc networks. Links between nodes are continuously established and broken because of the characteristics of the network. Finding multiple routes to increase the reliability is also important but requires a fast update, especially in high traffic load and high mobility where paths can be broken as well. The sender node keeps re-establishing path discovery to find new paths, which makes for long time delay. In this paper we propose an improved multipath routing protocol, called Receiver-based ad hoc on demand multipath routing protocol (RB-AOMDV), which takes advantage of the reliability of the state of the art ad hoc on demand multipath distance vector (AOMDV) protocol with less re-established discovery time. The receiver node assumes the role of discovering paths when finding data packets that have not been received after a period of time. Simulation results show the delay and delivery ratio performances are improved compared with AOMDV.

The discovery of long-term potentiation.

PubMed

Lømo, Terje

2003-04-29

This paper describes circumstances around the discovery of long-term potentiation (LTP). In 1966, I had just begun independent work for the degree of Dr medicinae (PhD) in Per Andersen's laboratory in Oslo after an eighteen-month apprenticeship with him. Studying the effects of activating the perforant path to dentate granule cells in the hippocampus of anaesthetized rabbits, I observed that brief trains of stimuli resulted in increased efficiency of transmission at the perforant path-granule cell synapses that could last for hours. In 1968, Tim Bliss came to Per Andersen's laboratory to learn about the hippocampus and field potential recording for studies of possible memory mechanisms. The two of us then followed up my preliminary results from 1966 and did the experiments that resulted in a paper that is now properly considered to be the basic reference for the discovery of LTP.

Microbial Efflux Systems and Inhibitors: Approaches to Drug Discovery and the Challenge of Clinical Implementation

PubMed Central

Kourtesi, Christina; Ball, Anthony R; Huang, Ying-Ying; Jachak, Sanjay M; Vera, D Mariano A; Khondkar, Proma; Gibbons, Simon; Hamblin, Michael R; Tegos, George P

2013-01-01

Conventional antimicrobials are increasingly ineffective due to the emergence of multidrug-resistance among pathogenic microorganisms. The need to overcome these deficiencies has triggered exploration for novel and unconventional approaches to controlling microbial infections. Multidrug efflux systems (MES) have been a profound obstacle in the successful deployment of antimicrobials. The discovery of small molecule efflux system blockers has been an active and rapidly expanding research discipline. A major theme in this platform involves efflux pump inhibitors (EPIs) from natural sources. The discovery methodologies and the available number of natural EPI-chemotypes are increasing. Advances in our understanding of microbial physiology have shed light on a series of pathways and phenotypes where the role of efflux systems is pivotal. Complementing existing antimicrobial discovery platforms such as photodynamic therapy (PDT) with efflux inhibition is a subject under investigation. This core information is a stepping stone in the challenge of highlighting an effective drug development path for EPIs since the puzzle of clinical implementation remains unsolved. This review summarizes advances in the path of EPI discovery, discusses potential avenues of EPI implementation and development, and underlines the need for highly informative and comprehensive translational approaches. PMID:23569468

Certification trails and software design for testability

NASA Technical Reports Server (NTRS)

Sullivan, Gregory F.; Wilson, Dwight S.; Masson, Gerald M.

1993-01-01

Design techniques which may be applied to make program testing easier were investigated. Methods for modifying a program to generate additional data which we refer to as a certification trail are presented. This additional data is designed to allow the program output to be checked more quickly and effectively. Certification trails were described primarily from a theoretical perspective. A comprehensive attempt to assess experimentally the performance and overall value of the certification trail method is reported. The method was applied to nine fundamental, well-known algorithms for the following problems: convex hull, sorting, huffman tree, shortest path, closest pair, line segment intersection, longest increasing subsequence, skyline, and voronoi diagram. Run-time performance data for each of these problems is given, and selected problems are described in more detail. Our results indicate that there are many cases in which certification trails allow for significantly faster overall program execution time than a 2-version programming approach, and also give further evidence of the breadth of applicability of this method.

The discovery of long-term potentiation.

PubMed Central

Lømo, Terje

2003-01-01

This paper describes circumstances around the discovery of long-term potentiation (LTP). In 1966, I had just begun independent work for the degree of Dr medicinae (PhD) in Per Andersen's laboratory in Oslo after an eighteen-month apprenticeship with him. Studying the effects of activating the perforant path to dentate granule cells in the hippocampus of anaesthetized rabbits, I observed that brief trains of stimuli resulted in increased efficiency of transmission at the perforant path-granule cell synapses that could last for hours. In 1968, Tim Bliss came to Per Andersen's laboratory to learn about the hippocampus and field potential recording for studies of possible memory mechanisms. The two of us then followed up my preliminary results from 1966 and did the experiments that resulted in a paper that is now properly considered to be the basic reference for the discovery of LTP. PMID:12740104

Survey alerts hospital to needs of consumers.

PubMed

Schoenfeldt, R C; Seale, W B; Hale, A W

1987-09-01

Because of rapidly changing developments in the healthcare field, more emphasis is being placed on marketing of hospital services. A hospital's success will depend more and more on strategic planning based on timely and accurate information. In light of this, Lourdes Hospital, Paducah, KY, undertook a survey to evaluate its current performance and to determine a path for the future. The survey found, among other discoveries, that patients want more voice in determining their own treatment; they prefer outpatient treatment when possible, even if it is not covered by insurance; and stress management and health assessment clinics are the most popular extra services a hospital could offer. Physicians surveyed said they wanted more input into the evaluation of new services and equipment at the hospital. The survey also found that most patients either select a hospital in conjunction with their physician or have their physician choose the hospital. The findings led to some major changes at the hospital, including a restructuring of the planning process to get physicians more involved, a new marketing strategy to enhance communication with consumers, and increased outpatient services. The results have given direction to the hospital administration, helped shape advertising, and provided support for certificate-of-need requests.

What is an "ideal" antibiotic? Discovery challenges and path forward.

PubMed

Singh, Sheo B; Young, Katherine; Silver, Lynn L

2017-06-01

An ideal antibiotic is an antibacterial agent that kills or inhibits the growth of all harmful bacteria in a host, regardless of site of infection without affecting beneficial gut microbes (gut flora) or causing undue toxicity to the host. Sadly, no such antibiotics exist. What exist are many effective Gram-positive antibacterial agents as well as broad-spectrum agents that provide treatment of certain Gram-negative bacteria but not holistic treatment of all bacteria. However effectiveness of all antibacterial agents is being rapidly eroded due to resistance. This viewpoint provides an overview of today's antibiotics, challenges and potential path forward of discovery and development of new (ideal) antibiotics. Copyright © 2017 Elsevier Inc. All rights reserved.

Soluble biomarkers development in osteoarthritis: from discovery to personalized medicine

PubMed Central

Henrotin, Yves; Sanchez, Christelle; Cornet, Anne; Van de Put, Joachim; Douette, Pierre; Gharbi, Myriam

2015-01-01

Abstract Context: Specific soluble biomarkers could be a precious tool for diagnosis, prognosis and personalized management of osteoarthritic (OA) patients. Objective: To describe the path of soluble biomarker development from discovery to clinical qualification and regulatory adoption toward OA-related biomarker qualification. Methods and results: This review summarizes current guidance on the use of biomarkers in OA in clinical trials and their utility at five stages, including preclinical development and phase 1 to phase 4 trials. It also presents all the available regulatory requirements. Conclusions: The path through the adoption of a specific soluble biomarker for OA is steep but is worth the challenge due to the benefit that it can provide. PMID:26954785

Towards Detection of Learner Misconceptions in a Medical Learning Environment: A Subgroup Discovery Approach

ERIC Educational Resources Information Center

Poitras, Eric G.; Doleck, Tenzin; Lajoie, Susanne P.

2018-01-01

Ill-structured problems, by definition, have multiple paths to a solution and are multifaceted making automated assessment and feedback a difficult challenge. Diagnostic reasoning about medical cases meet the criteria of ill-structured problem solving since there are multiple solution paths. The goal of this study was to develop an adaptive…

Inventions: Waiting for Eureka

ERIC Educational Resources Information Center

Engelfried, Steven

2010-01-01

Legend has it that when Archimedes made a discovery related to water displacement, he leapt out of a bath declaring, "Eureka!" Whether true or not, the tale serves as a symbol for the notion that a burst of inspiration can lead to an exciting new discovery. Most books about inventions, however, tell a different story. The path from the germ of an…

Radiation Detection Material Discovery Initiative at PNNL

NASA Astrophysics Data System (ADS)

Milbrath, Brian

2006-05-01

Today's security threats are being met with 30-year old radiation technology. Discovery of new radiation detection materials is currently a slow and Edisonian process. With heightened concerns over nuclear proliferation, terrorism and unconventional warfare, an alternative strategy for identification and development of potential radiation detection materials must be adopted. Through the Radiation Detection Materials Discovery Initiative, PNNL focuses on the science-based discovery of next generation materials for radiation detection by addressing three ``grand challenges'': fundamental understanding of radiation detection, identification of new materials, and accelerating the discovery process. The new initiative has eight projects addressing these challenges, which will be described, including early work, paths forward and the opportunities for collaboration.

Kleinberg Complex Networks

DTIC Science & Technology

2014-10-21

linear combinations of paths. This project featured research on two classes of routing problems , namely traveling salesman problems and multicommodity...flows. One highlight of this research was our discovery of a polynomial-time algorithm for the metric traveling salesman s-t path problem whose...metric TSP would resolve one of the most venerable open problems in the theory of approximation algorithms. Our research on traveling salesman

BCL-2: Long and winding path from discovery to therapeutic target

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schenk, Robyn L.; Strasser, Andreas; Department of Medical Biology, University of Melbourne, Parkville, Melbourne, Victoria 3010

In 1988, the BCL-2 protein was found to promote cancer by limiting cell death rather than enhancing proliferation. This discovery set the wheels in motion for an almost 30 year journey involving many international research teams that has recently culminated in the approval for a drug, ABT-199/venetoclax/Venclexta that targets this protein in the treatment of cancer. This review will describe the long and winding path from the discovery of this protein and understanding the fundamental process of apoptosis that BCL-2 and its numerous homologues control, through to its exploitation as a drug target that is set to have significant benefitmore » for cancer patients. - Highlights: • BCL-2 proteins control the intrinsic or mitochondrial pathway of apoptosis. • Defective apoptosis is a hallmark of cancer. • BH3-mimetics inhibit pro-survival BCL-2 proteins to induce cancer cell death. • ABT-199/venetoclax is approved for treatment of chronic lymphocytic leukaemia.« less

Biology-driven library design for probe discovery.

PubMed

Inglese, James; Hasson, Samuel A

2011-10-28

Libraries of diverse small molecules are important to probe and drug discovery. The current trend toward building massive screening collections to support drug development, a special application of chemical biology, can limit their broader potential. Biology-driven construction methods (Wallace et al., 2011) are rapidly emerging to bring chemical libraries back on a viable path. Copyright © 2011 Elsevier Ltd. All rights reserved.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Canfield, Paul C.

Materials science research can be both very demanding and extremely rewarding. In this Commentary, in my own research of new electronic and magnetic materials, I give numerous exemplars of the path followed to materials discovery. I also highlight the parallels between my research experiences with the pastime of running. I hope that my thoughts will help guide junior researchers along the often tortuous and exciting path to new materials and that I can teach them to be open minded and persistent about following new lines of discovery. “No-pain, no-gain” applies to many things in life, running and scientific research beingmore » just two examples, but I hope in the case of scientific research that I can convince you the gain normally outweighs the pain.« less

Certification Strategies using Run-Time Safety Assurance for Part 23 Autopilot Systems

NASA Technical Reports Server (NTRS)

Hook, Loyd R.; Clark, Matthew; Sizoo, David; Skoog, Mark A.; Brady, James

2016-01-01

Part 23 aircraft operation, and in particular general aviation, is relatively unsafe when compared to other common forms of vehicle travel. Currently, there exists technologies that could increase safety statistics for these aircraft; however, the high burden and cost of performing the requisite safety critical certification processes for these systems limits their proliferation. For this reason, many entities, including the Federal Aviation Administration, NASA, and the US Air Force, are considering new options for certification for technologies that will improve aircraft safety. Of particular interest, are low cost autopilot systems for general aviation aircraft, as these systems have the potential to positively and significantly affect safety statistics. This paper proposes new systems and techniques, leveraging run-time verification, for the assurance of general aviation autopilot systems, which would be used to supplement the current certification process and provide a viable path for near-term low-cost implementation. In addition, discussions on preliminary experimentation and building the assurance case for a system, based on these principles, is provided.

Putting Paraeducators on the Path to Teacher Certification

ERIC Educational Resources Information Center

Morrison, Judith; Lightner, Lindsay

2017-01-01

In response to local districts' needs for certified teachers with community roots who understand local schools and students, the authors developed an innovative alternative route for paraprofessionals based on a traditional bachelor's program. Their goals were to provide a rigorous, research-based program that allows paraprofessionals to get a…

"Fast Track" and "Traditional Path" Coaches: Affordances, Agency and Social Capital

ERIC Educational Resources Information Center

Rynne, Steven

2014-01-01

A recent development in large-scale coach accreditation (certification) structures has been the "fast tracking" of former elite athletes. Former elite athletes are often exempted from entry-level qualifications and are generally granted access to fast track courses that are shortened versions of the accreditation courses undertaken by…

Certification of computational results

NASA Technical Reports Server (NTRS)

Sullivan, Gregory F.; Wilson, Dwight S.; Masson, Gerald M.

1993-01-01

A conceptually novel and powerful technique to achieve fault detection and fault tolerance in hardware and software systems is described. When used for software fault detection, this new technique uses time and software redundancy and can be outlined as follows. In the initial phase, a program is run to solve a problem and store the result. In addition, this program leaves behind a trail of data called a certification trail. In the second phase, another program is run which solves the original problem again. This program, however, has access to the certification trail left by the first program. Because of the availability of the certification trail, the second phase can be performed by a less complex program and can execute more quickly. In the final phase, the two results are compared and if they agree the results are accepted as correct; otherwise an error is indicated. An essential aspect of this approach is that the second program must always generate either an error indication or a correct output even when the certification trail it receives from the first program is incorrect. The certification trail approach to fault tolerance is formalized and realizations of it are illustrated by considering algorithms for the following problems: convex hull, sorting, and shortest path. Cases in which the second phase can be run concurrently with the first and act as a monitor are discussed. The certification trail approach are compared to other approaches to fault tolerance.

Smell Detection Agent Based Optimization Algorithm

NASA Astrophysics Data System (ADS)

Vinod Chandra, S. S.

2016-09-01

In this paper, a novel nature-inspired optimization algorithm has been employed and the trained behaviour of dogs in detecting smell trails is adapted into computational agents for problem solving. The algorithm involves creation of a surface with smell trails and subsequent iteration of the agents in resolving a path. This algorithm can be applied in different computational constraints that incorporate path-based problems. Implementation of the algorithm can be treated as a shortest path problem for a variety of datasets. The simulated agents have been used to evolve the shortest path between two nodes in a graph. This algorithm is useful to solve NP-hard problems that are related to path discovery. This algorithm is also useful to solve many practical optimization problems. The extensive derivation of the algorithm can be enabled to solve shortest path problems.

An Analysis of Automated Solutions for the Certification and Accreditation of Navy Medicine Information Assets

DTIC Science & Technology

2005-09-01

discovery of network security threats and vulnerabilities will be done by doing penetration testing during the C&A process. This can be done on a...2.1.1; Appendix E, J COBR -1 Protection of Backup and Restoration Assets Availability 1.3.1; 2.1.3; 2.1.7; 3.1; 4.3; Appendix J, M CODB-2 Data... discovery , inventory, scanning and loading of C&A information in its central database, (2) automatic generation of the SRTM , (3) automatic generation

22 CFR 34.18 - Waivers of indebtedness.

Code of Federal Regulations, 2011 CFR

2011-04-01

... known through the exercise of due diligence that an error existed but failed to take corrective action... elapsed between the erroneous payment and discovery of the error and notification of the employee; (D... to duty because of disability (supported by an acceptable medical certificate); and (D) Whether...

How the Army Meter Data Management System (MDMS) Can Help on the Path to Net Zero

DTIC Science & Technology

2011-05-10

NY) • Meets DoD cyber-security requirements – Received Authority to Operate from Army NETCOM effective 23 April 2010 – Received Certificate of...How MDMS supports Net Zero Goals (cont) 4. Measure Production/Consumption balance a. Only way to demonstrate position on glide path to Net Zero 5...2010001D To 8 Aug 2010 00 00 En•l’iY f*ttk COnWtnptlon J96S9U81’ WII FillCilftl .. Totol , ......... ~ Metert - Met el\\ r;’l £1Htr1< 1....-J G.n

Against the Current

ERIC Educational Resources Information Center

Williamson, Lisa Ann

2011-01-01

Schools of education at colleges and universities are still the primary source of new teachers in U.S. schools. For the last generation, however, a small but growing stream of people has been taking a different path to the front of the classroom. These new teachers are the fruit of alternative teacher certification programs, programs that quickly…

Evaluating the Efficacy of a Healthcare Fellowship Certification Program as an Indication of Career Preparedness

ERIC Educational Resources Information Center

Jobes, Tammy L. Kester Engel

2017-01-01

Healthcare administration is a complex, multifaceted career path that requires constant adaptation and integration of external guidance. Organizations seeking the most qualified and skilled candidates draw from a multitude of applicants without having a single potential success indicator. The lack of a standard educational background,…

Network-based discovery through mechanistic systems biology. Implications for applications--SMEs and drug discovery: where the action is.

PubMed

Benson, Neil

2015-08-01

Phase II attrition remains the most important challenge for drug discovery. Tackling the problem requires improved understanding of the complexity of disease biology. Systems biology approaches to this problem can, in principle, deliver this. This article reviews the reports of the application of mechanistic systems models to drug discovery questions and discusses the added value. Although we are on the journey to the virtual human, the length, path and rate of learning from this remain an open question. Success will be dependent on the will to invest and make the most of the insight generated along the way. Copyright © 2015 Elsevier Ltd. All rights reserved.

On the Effects of Modeling As-Manufactured Geometry: Toward Digital Twin

NASA Technical Reports Server (NTRS)

Cerrone, Albert; Hochhalter, Jacob; Heber, Gerd; Ingraffea, Anthony

2014-01-01

Asimple, nonstandardized material test specimen,which fails along one of two different likely crack paths, is considered herein.The result of deviations in geometry on the order of tenths of amillimeter, this ambiguity in crack pathmotivates the consideration of asmanufactured component geometry in the design, assessment, and certification of structural systems.Herein, finite elementmodels of as-manufactured specimens are generated and subsequently analyzed to resolve the crack-path ambiguity. The consequence and benefit of such a "personalized" methodology is the prediction of a crack path for each specimen based on its as-manufactured geometry, rather than a distribution of possible specimen geometries or nominal geometry.The consideration of as-manufactured characteristics is central to the Digital Twin concept. Therefore, this work is also intended to motivate its development.

Econometrics of exhaustible resource supply: a theory and an application. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Epple, D.; Hansen, L.P.

1981-12-01

An econometric model of US oil and natural gas discoveries is developed in this study. The econometric model is explicitly derived as the solution to the problem of maximizing the expected discounted after tax present value of revenues net of exploration, development, and production costs. The model contains equations representing producers' formation of price expectations and separate equations giving producers' optimal exploration decisions contingent on expected prices. A procedure is developed for imposing resource base constraints (e.g., ultimate recovery estimates based on geological analysis) when estimating the econometric model. The model is estimated using aggregate post-war data for the Unitedmore » States. Production from a given addition to proved reserves is assumed to follow a negative exponential path, and additions of proved reserves from a given discovery are assumed to follow a negative exponential path. Annual discoveries of oil and natural gas are estimated as latent variables. These latent variables are the endogenous variables in the econometric model of oil and natural gas discoveries. The model is estimated without resource base constraints. The model is also estimated imposing the mean oil and natural gas ultimate recovery estimates of the US Geological Survey. Simulations through the year 2020 are reported for various future price regimes.« less

Chemseal 3808-A2 penetration into small leak path

NASA Technical Reports Server (NTRS)

Carruth, M. R., Jr.; Dehaye, R. F.

1988-01-01

A possible fix to a leak in the oxidizer system of the Space Shuttle Discovery's attitude control system was proposed by MSFC. This fix involved the passing of a shuttlecock past the leaking Dynaflow fitting and sealing the vent tube containing the fitting with Chemseal 3808-A2. The question of whether the Chemseal 3808-A2 can flow into the leak path and provide a better seal was addressed analytically and by experiment to verify the analytical formula used. The results show that the equations are applicable and that the Chemseal will flow into the expected leak path and seal.

Points on the Path to Probability.

ERIC Educational Resources Information Center

Kiernan, James F.

2001-01-01

Presents the problem of points and the development of the binomial triangle, or Pascal's triangle. Examines various attempts to solve this problem to give students insight into the nature of mathematical discovery. (KHR)

77 FR 11345 - Harmonization of Compliance Obligations for Registered Investment Companies Required To Register...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-24

... his or her knowledge and belief, the information contained in the document is accurate and complete. The first item in the certification required by SEC Form N-CSR is: ``Based on my knowledge, this..., competitiveness and financial integrity of futures markets; (3) price discovery; (4) sound risk management...

40 CFR 86.449 - Averaging provisions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... certification: (1) A statement that, to the best of your belief, you will not have a negative credit balance for... point of first retail sale. This point is called the final product-purchase location. (3) Send end-of... your credit balance The discovery occurs within 180 days of receipt Restore the credits for your use...

The Search for Life Beyond Earth

NASA Image and Video Library

2014-07-14

NASA Administrator Charles Bolden delivers opening remarks during a panel discussion on the search for life beyond Earth in the James E. Webb Auditorium at NASA Headquarters on Monday, July 14, 2014 in Washington, DC. The panel discussed how NASA's space-based observatories are making new discoveries and how the agency's new telescope, the James Webb Space Telescope, will continue this path of discovery after its schedule launch in 2018. Photo Credit: (NASA/Joel Kowsky)

Closing the Classroom Door and the Achievement Gap: Teach for America Alumni Teachers' Appropriation of Arizona Language Policy

ERIC Educational Resources Information Center

Heineke, Amy J.; Cameron, Quanna

2013-01-01

This qualitative study explored Teach for America (TFA) alumni teachers' discourse on Arizona language policy, conducted with eight teachers in the Phoenix metropolitan area who received their professional teacher preparation from TFA, a national organization that uses alternative paths to certification to place teachers in low-income schools.…

From the Tightrope: Designing, Developing, and Delivering an Alternative Teacher Education Model

ERIC Educational Resources Information Center

Yancey, Patty

2006-01-01

In the fall of 2003 a number of factors came together to create a fertile environment for developing an alternative, pre-service teacher education model. The overarching goal of the model is to diversify a rural university's credential program(s) by developing and offering alternative paths toward teacher certification within the constraints of a…

76 FR 42161 - Notice of Final Federal Agency Actions on Proposed Highway in California

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-18

... Gilman Drive; installation of new ramp meters; and, construction of a bicycle path along I-5. The project... at http://www.dot.ca.gov/dist11/envir.htm . Pending Federal actions include: 1. Section 401 Water Quality Certification from the San Diego Regional Water Quality Control Board (RWQCB), under Section 401...

What Makes Them Do It? School Librarians Join the Select Band of Board-Certified Teachers.

ERIC Educational Resources Information Center

Russell, Sandy; Sayers, Ann

2002-01-01

School library media specialists from all grade levels have embarked on the path toward certification through the National Board for Professional Teaching Standards (NBPTS). Discusses some background to the NBPTS and who the current candidates are. A sidebar presents a brief explanation of each of 13 dimensions of teaching expertise. (AEF)

A Descriptive Analysis of the Principal Workforce in Florida Schools. REL 2015-068

ERIC Educational Resources Information Center

Folsom, Jessica Sidler; Osborne-Lampkin, La'Tara; Herrington, Carolyn

2015-01-01

This report describes the results of a REL Southeast study using the Florida Department of Education staffing database to describe the demographic make-up, Florida Educator Certificate coverages, career paths from 2001/02 to 2011/12, and evaluation ratings of Florida's educational leaders (i.e., assistant principals and principals) in the 2011/12…

A unified approach to computational drug discovery.

PubMed

Tseng, Chih-Yuan; Tuszynski, Jack

2015-11-01

It has been reported that a slowdown in the development of new medical therapies is affecting clinical outcomes. The FDA has thus initiated the Critical Path Initiative project investigating better approaches. We review the current strategies in drug discovery and focus on the advantages of the maximum entropy method being introduced in this area. The maximum entropy principle is derived from statistical thermodynamics and has been demonstrated to be an inductive inference tool. We propose a unified method to drug discovery that hinges on robust information processing using entropic inductive inference. Increasingly, applications of maximum entropy in drug discovery employ this unified approach and demonstrate the usefulness of the concept in the area of pharmaceutical sciences. Copyright © 2015. Published by Elsevier Ltd.

An Operational Safety and Certification Assessment of a TASAR EFB Application

NASA Technical Reports Server (NTRS)

Koczo, Stefan; Wing, David

2013-01-01

This paper presents an overview of a Traffic Aware Strategic Aircrew Requests (TASAR) Electronic Flight Bag application intended to inform the pilot of trajectory improvement opportunities while en route that result in operational benefits. The results of safety analyses and a detailed review of Federal Aviation Administration (FAA) regulatory documents that establish certification and operational approval requirements are presented for TASAR. The safety analyses indicate that TASAR has a likely Failure Effects Classification of “No Effect,” and at most, is no worse than “Minor Effect.” Based on this safety assessment and the detailed review of FAA regulatory documents that determine certification and operational approval requirements, this study concludes that TASAR can be implemented in the flight deck as a Type B software application hosted on a Class 2 Portable Electronic Device (PED) Electronic Flight Bag (EFB). This implementation approach would provide a relatively low-cost path to certification and operational approval for both retrofit and forward fit implementation, while at the same time facilitating the business case for early ADS-B IN equipage. A preliminary review by FAA certification and operational approvers of the analyses presented here confirmed that the conclusions are appropriate and that TASAR will be considered a Type B application.

Experimental evaluation of the certification-trail method

NASA Technical Reports Server (NTRS)

Sullivan, Gregory F.; Wilson, Dwight S.; Masson, Gerald M.; Itoh, Mamoru; Smith, Warren W.; Kay, Jonathan S.

1993-01-01

Certification trails are a recently introduced and promising approach to fault-detection and fault-tolerance. A comprehensive attempt to assess experimentally the performance and overall value of the method is reported. The method is applied to algorithms for the following problems: huffman tree, shortest path, minimum spanning tree, sorting, and convex hull. Our results reveal many cases in which an approach using certification-trails allows for significantly faster overall program execution time than a basic time redundancy-approach. Algorithms for the answer-validation problem for abstract data types were also examined. This kind of problem provides a basis for applying the certification-trail method to wide classes of algorithms. Answer-validation solutions for two types of priority queues were implemented and analyzed. In both cases, the algorithm which performs answer-validation is substantially faster than the original algorithm for computing the answer. Next, a probabilistic model and analysis which enables comparison between the certification-trail method and the time-redundancy approach were presented. The analysis reveals some substantial and sometimes surprising advantages for ther certification-trail method. Finally, the work our group performed on the design and implementation of fault injection testbeds for experimental analysis of the certification trail technique is discussed. This work employs two distinct methodologies, software fault injection (modification of instruction, data, and stack segments of programs on a Sun Sparcstation ELC and on an IBM 386 PC) and hardware fault injection (control, address, and data lines of a Motorola MC68000-based target system pulsed at logical zero/one values). Our results indicate the viability of the certification trail technique. It is also believed that the tools developed provide a solid base for additional exploration.

The Search for Life Beyond Earth

NASA Image and Video Library

2014-07-14

John Grunsfeld, Associate Administrator for NASA's Science Mission Directorate, far left, speaks during a panel discussion on the search for life beyond Earth in the James E. Webb Auditorium at NASA Headquarters on Monday, July 14, 2014 in Washington, DC. The panel discussed how NASA's space-based observatories are making new discoveries and how the agency's new telescope, the James Webb Space Telescope, will continue this path of discovery after its schedule launch in 2018. Photo Credit: (NASA/Joel Kowsky)

The Search for Life Beyond Earth

NASA Image and Video Library

2014-07-14

NASA Chief Scientist Ellen Stofan, far left, introduces members of the panel prior to a discussion of the search for life beyond Earth in the James E. Webb Auditorium at NASA Headquarters on Monday, July 14, 2014 in Washington, DC. The panel discussed how NASA's space-based observatories are making new discoveries and how the agency's new telescope, the James Webb Space Telescope, will continue this path of discovery after its schedule launch in 2018. Photo Credit: (NASA/Joel Kowsky)

High Costs, Uncertain Benefits: What Do Americans without a College Degree Think about Postsecondary Education?

ERIC Educational Resources Information Center

Kelly, Andrew P.

2015-01-01

The path to economic mobility increasingly runs through postsecondary education. Although the combination of rising tuition prices and a difficult labor market have raised questions about the value of education after high school, degree and certificate holders are still better off than those with just a high school diploma. As a group, young…

Pathways to the Principalship: An Event History Analysis of the Careers of Teachers with Principal Certification

ERIC Educational Resources Information Center

Davis, Bradley W.; Gooden, Mark A.; Bowers, Alex J.

2017-01-01

Utilizing rich data on nearly 11,000 educators over 17 academic years in a highly diverse context, we examine the career paths of teachers to determine whether and when they transition into the principalship. We utilize a variety of event history analyses, including discrete-time hazard modeling, to determine how an individual's race, gender, and…

The path to producing pharmaceuticals from natural products uncovered by academia-from the perspective of a science coordinator.

PubMed

Fujie, Akihiko

2017-01-01

To actualize the invention of all-Japanese medicines, the Department of Innovative Drug Discovery and Development (iD3) in the Japan Agency for Medical Research and Development (AMED) serves as the headquarters for the Drug Discovery Support Network. iD3 assists with creating research strategies for the seeds of medicines discovered by academia and provides technological support, intellectual property management, and aid for applying the seeds through industry-led efforts. In this review, from the perspective of a science coordinator, I will describe the current activities of the drug discovery support network and iD3 as well as the challenges and future developments of pharmaceutical research and development using the natural product drug discovery method.

Allosteric Tuning of Caspase-7: A Fragment-Based Drug Discovery Approach.

PubMed

Vance, Nicholas R; Gakhar, Lokesh; Spies, M Ashley

2017-11-13

The caspase family of cysteine proteases are highly sought-after drug targets owing to their essential roles in apoptosis, proliferation, and inflammation pathways. High-throughput screening efforts to discover inhibitors have gained little traction. Fragment-based screening has emerged as a powerful approach for the discovery of innovative drug leads. This method has become a central facet of drug discovery campaigns in the pharmaceutical industry and academia. A fragment-based drug discovery campaign against human caspase-7 resulted in the discovery of a novel series of allosteric inhibitors. An X-ray crystal structure of caspase-7 bound to a fragment hit and a thorough kinetic characterization of a zymogenic form of the enzyme were used to investigate the allosteric mechanism of inhibition. This work further advances our understanding of the mechanisms of allosteric control of this class of pharmaceutically relevant enzymes, and provides a new path forward for drug discovery efforts. © 2017 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.

The Search for Life Beyond Earth

NASA Image and Video Library

2014-07-14

Dave Gallagher, Director of Astronomy, Physics, and Space Technology at NASA's Jet Propulsion Laboratory speaks during a panel discussion on the search for life beyond Earth in the James E. Webb Auditorium at NASA Headquarters on Monday, July 14, 2014 in Washington, DC. The panel discussed how NASA's space-based observatories are making new discoveries and how the agency's new telescope, the James Webb Space Telescope, will continue this path of discovery after its schedule launch in 2018. Photo Credit: (NASA/Joel Kowsky)

The Search for Life Beyond Earth

NASA Image and Video Library

2014-07-14

Sara Seager, a MacArthur Fellow and Professor of Planetary Science and Physics at the Massachusetts Institute of Technology, speaks during a panel discussion on the search for life beyond Earth in the James E. Webb Auditorium at NASA Headquarters on Monday, July 14, 2014 in Washington, DC. The panel discussed how NASA's space-based observatories are making new discoveries and how the agency's new telescope, the James Webb Space Telescope, will continue this path of discovery after its schedule launch in 2018. Photo Credit: (NASA/Joel Kowsky)

The Search for Life Beyond Earth

NASA Image and Video Library

2014-07-14

John Grunsfeld, Associate Administrator for NASA's Science Mission Directorate, second from left, answers a question from the audience during a panel discussion on the search for life beyond Earth in the James E. Webb Auditorium at NASA Headquarters on Monday, July 14, 2014 in Washington, DC. The panel discussed how NASA's space-based observatories are making new discoveries and how the agency's new telescope, the James Webb Space Telescope, will continue this path of discovery after its schedule launch in 2018. Photo Credit: (NASA/Joel Kowsky)

The Search for Life Beyond Earth

NASA Image and Video Library

2014-07-14

John Grunsfeld, Associate Administrator for NASA's Science Mission Directorate, far left, answers a question from the audience during a panel discussion on the search for life beyond Earth in the James E. Webb Auditorium at NASA Headquarters on Monday, July 14, 2014 in Washington, DC. The panel discussed how NASA's space-based observatories are making new discoveries and how the agency's new telescope, the James Webb Space Telescope, will continue this path of discovery after its schedule launch in 2018. Photo Credit: (NASA/Joel Kowsky)

The Search for Life Beyond Earth

NASA Image and Video Library

2014-07-14

Matt Mountain, Director of the Space Telescope Science Institute and telescope scientist for the James Webb Space Telescope, speaks during a panel discussion on the search for life beyond Earth in the James E. Webb Auditorium at NASA Headquarters on Monday, July 14, 2014 in Washington, DC. The panel discussed how NASA's space-based observatories are making new discoveries and how the agency's new telescope, the James Webb Space Telescope, will continue this path of discovery after its schedule launch in 2018. Photo Credit: (NASA/Joel Kowsky)

The Search for Life Beyond Earth

NASA Image and Video Library

2014-07-14

John Mather, Nobel Laureate and Project Scientist for the James Webb Space Telescope at NASA's Goddard Space Flight Center, speaks during a panel discussion on the search for life beyond Earth in the James E. Webb Auditorium at NASA Headquarters on Monday, July 14, 2014 in Washington, DC. The panel discussed how NASA's space-based observatories are making new discoveries and how the agency's new telescope, the James Webb Space Telescope, will continue this path of discovery after its schedule launch in 2018. Photo Credit: (NASA/Joel Kowsky)

The Search for Life Beyond Earth

NASA Image and Video Library

2014-07-14

NASA Chief Scientist Ellen Stofan, far left, asks the members of the panel a question during a discussion of the search for life beyond Earth in the James E. Webb Auditorium at NASA Headquarters on Monday, July 14, 2014 in Washington, DC. The panel discussed how NASA's space-based observatories are making new discoveries and how the agency's new telescope, the James Webb Space Telescope, will continue this path of discovery after its schedule launch in 2018. Photo Credit: (NASA/Joel Kowsky)

Cosmic Rays: "A Thin Rain of Charged Particles."

ERIC Educational Resources Information Center

Friedlander, Michael

1990-01-01

Discussed are balloons and electroscopes, understanding cosmic rays, cosmic ray paths, isotopes and cosmic-ray travel, sources of cosmic rays, and accelerating cosmic rays. Some of the history of the discovery and study of cosmic rays is presented. (CW)

Pep2Path: automated mass spectrometry-guided genome mining of peptidic natural products.

PubMed

Medema, Marnix H; Paalvast, Yared; Nguyen, Don D; Melnik, Alexey; Dorrestein, Pieter C; Takano, Eriko; Breitling, Rainer

2014-09-01

Nonribosomally and ribosomally synthesized bioactive peptides constitute a source of molecules of great biomedical importance, including antibiotics such as penicillin, immunosuppressants such as cyclosporine, and cytostatics such as bleomycin. Recently, an innovative mass-spectrometry-based strategy, peptidogenomics, has been pioneered to effectively mine microbial strains for novel peptidic metabolites. Even though mass-spectrometric peptide detection can be performed quite fast, true high-throughput natural product discovery approaches have still been limited by the inability to rapidly match the identified tandem mass spectra to the gene clusters responsible for the biosynthesis of the corresponding compounds. With Pep2Path, we introduce a software package to fully automate the peptidogenomics approach through the rapid Bayesian probabilistic matching of mass spectra to their corresponding biosynthetic gene clusters. Detailed benchmarking of the method shows that the approach is powerful enough to correctly identify gene clusters even in data sets that consist of hundreds of genomes, which also makes it possible to match compounds from unsequenced organisms to closely related biosynthetic gene clusters in other genomes. Applying Pep2Path to a data set of compounds without known biosynthesis routes, we were able to identify candidate gene clusters for the biosynthesis of five important compounds. Notably, one of these clusters was detected in a genome from a different subphylum of Proteobacteria than that in which the molecule had first been identified. All in all, our approach paves the way towards high-throughput discovery of novel peptidic natural products. Pep2Path is freely available from http://pep2path.sourceforge.net/, implemented in Python, licensed under the GNU General Public License v3 and supported on MS Windows, Linux and Mac OS X.

Progressing from programmatic to discovery research: a case example with the overjustification effect.

PubMed

Roane, Henry S; Fisher, Wayne W; McDonough, Erin M

2003-01-01

Scientific research progresses along planned (programmatic research) and unplanned (discovery research) paths. In the current investigation, we attempted to conduct a single-case evaluation of the overjustification effect (i.e., programmatic research). Results of the initial analysis were contrary to the overjustification hypothesis in that removal of the reward contingency produced an increase in responding. Based on this unexpected finding, we conducted subsequent analyses to further evaluate the mechanisms underlying these results (i.e., discovery research). Results of the additional analyses suggested that the reward contingency functioned as punishment (because the participant preferred the task to the rewards) and that withdrawal of the contingency produced punishment contrast.

Progressing from programmatic to discovery research: a case example with the overjustification effect.

PubMed Central

Roane, Henry S; Fisher, Wayne W; McDonough, Erin M

2003-01-01

Scientific research progresses along planned (programmatic research) and unplanned (discovery research) paths. In the current investigation, we attempted to conduct a single-case evaluation of the overjustification effect (i.e., programmatic research). Results of the initial analysis were contrary to the overjustification hypothesis in that removal of the reward contingency produced an increase in responding. Based on this unexpected finding, we conducted subsequent analyses to further evaluate the mechanisms underlying these results (i.e., discovery research). Results of the additional analyses suggested that the reward contingency functioned as punishment (because the participant preferred the task to the rewards) and that withdrawal of the contingency produced punishment contrast. PMID:12723865

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rhinefrank, Kenneth E.; Lenee-Bluhm, Pukha; Prudell, Joseph H.

The most prudent path to a full-scale design, build and deployment of a wave energy conversion (WEC) system involves establishment of validated numerical models using physical experiments in a methodical scaling program. This Project provides essential additional rounds of wave tank testing at 1:33 scale and ocean/bay testing at a 1:7 scale, necessary to validate numerical modeling that is essential to a utility-scale WEC design and associated certification.

Astrobiology Science and Technology: A Path to Future Discovery

NASA Technical Reports Server (NTRS)

Meyer, M. A.; Lavaery, D. B.

2001-01-01

The Astrobiology Program is described. However, science-driven robotic exploration of extreme environments is needed for a new era of planetary exploration requiring biologically relevant instrumentation and extensive, autonomous operations on planetary surfaces. Additional information is contained in the original extended abstract.

Service discovery with routing protocols for MANETs

NASA Astrophysics Data System (ADS)

Gu, Xuemai; Shi, Shuo

2005-11-01

Service discovery is becoming an important topic as its use throughout the Internet becomes more widespread. In Mobile Ad hoc Networks (MANETs), the routing protocol is very important because it is special network. To find a path for data, and destination nodes, nodes send packets to each node, creating substantial overhead traffic and consuming much time. Even though a variety of routing protocols have been developed for use in MANETs, they are insufficient for reducing overhead traffic and time. In this paper, we propose SDRP: a new service discovery protocol combined with routing policies in MANETs. The protocol is performed upon a distributed network. We describe a service by a unique ID number and use a group-cast routing policy in advertisement and request. The group-cast routing policy decreases the traffic in networks, and it is efficient to find destination node. In addition, the nodes included in the reply path also cache the advertisement information, and it means when each node finds a node next time, they can know where it is as soon as possible, so they minimize the time. Finally, we compare SDRP with both Flood and MAODV in terms of overload, and average delay. Simulation results show SDRP can spend less response time and accommodate even high mobility network environments.

A Metadata based Knowledge Discovery Methodology for Seeding Translational Research.

PubMed

Kothari, Cartik R; Payne, Philip R O

2015-01-01

In this paper, we present a semantic, metadata based knowledge discovery methodology for identifying teams of researchers from diverse backgrounds who can collaborate on interdisciplinary research projects: projects in areas that have been identified as high-impact areas at The Ohio State University. This methodology involves the semantic annotation of keywords and the postulation of semantic metrics to improve the efficiency of the path exploration algorithm as well as to rank the results. Results indicate that our methodology can discover groups of experts from diverse areas who can collaborate on translational research projects.

The Search for Life Beyond Earth

NASA Image and Video Library

2014-07-14

John Mather, Project Scientist for the James Webb Space Telescope at NASA's Goddard Space Flight Center, center, answers a question from the audience during a panel discussion on the search for life beyond Earth in the James E. Webb Auditorium at NASA Headquarters on Monday, July 14, 2014 in Washington, DC. The panel discussed how NASA's space-based observatories are making new discoveries and how the agency's new telescope, the James Webb Space Telescope, will continue this path of discovery after its schedule launch in 2018. Photo Credit: (NASA/Joel Kowsky)

The Search for Life Beyond Earth

NASA Image and Video Library

2014-07-14

An animation of the James Webb Space Telescope (JWST) is projected as John Mather, Nobel Laureate and Project Scientist for the JWST speaks during a panel discussion on the search for life beyond Earth in the James E. Webb Auditorium at NASA Headquarters on Monday, July 14, 2014 in Washington, DC. The panel discussed how NASA's space-based observatories are making new discoveries and how the agency's new telescope, the James Webb Space Telescope, will continue this path of discovery after its schedule launch in 2018. Photo Credit: (NASA/Joel Kowsky)

The Search for Life Beyond Earth

NASA Image and Video Library

2014-07-14

Members of the audience walk past an example of a 1.2 meter telescope mirror that could be used in a future space telescope following a panel discussion on the search for life beyond Earth in the James E. Webb Auditorium at NASA Headquarters on Monday, July 14, 2014 in Washington, DC. The panel discussed how NASA's space-based observatories are making new discoveries and how the agency's new telescope, the James Webb Space Telescope, will continue this path of discovery after its schedule launch in 2018. Photo Credit: (NASA/Joel Kowsky)

CNS Anticancer Drug Discovery and Development Conference White Paper

PubMed Central

Levin, Victor A.; Tonge, Peter J.; Gallo, James M.; Birtwistle, Marc R.; Dar, Arvin C.; Iavarone, Antonio; Paddison, Patrick J.; Heffron, Timothy P.; Elmquist, William F.; Lachowicz, Jean E.; Johnson, Ted W.; White, Forest M.; Sul, Joohee; Smith, Quentin R.; Shen, Wang; Sarkaria, Jann N.; Samala, Ramakrishna; Wen, Patrick Y.; Berry, Donald A.; Petter, Russell C.

2015-01-01

Following the first CNS Anticancer Drug Discovery and Development Conference, the speakers from the first 4 sessions and organizers of the conference created this White Paper hoping to stimulate more and better CNS anticancer drug discovery and development. The first part of the White Paper reviews, comments, and, in some cases, expands on the 4 session areas critical to new drug development: pharmacological challenges, recent drug approaches, drug targets and discovery, and clinical paths. Following this concise review of the science and clinical aspects of new CNS anticancer drug discovery and development, we discuss, under the rubric “Accelerating Drug Discovery and Development for Brain Tumors,” further reasons why the pharmaceutical industry and academia have failed to develop new anticancer drugs for CNS malignancies and what it will take to change the current status quo and develop the drugs so desperately needed by our patients with malignant CNS tumors. While this White Paper is not a formal roadmap to that end, it should be an educational guide to clinicians and scientists to help move a stagnant field forward. PMID:26403167

Federation for a Secure Enterprise

DTIC Science & Technology

2016-09-10

12 October 2005 e. RFC Internet X.509 Public Key Infrastructure: Certification Path Building, 2005 f. Public Key Cryptography Standard, PKCS #1...v2.2: RSA Cryptography Standard, RSA Laboratories, October 27, 2012 g. PKCS#12 format PKCS #12 v1.0: Personal Information Exchange Syntax Standard, RSA...ClientHello padding extension, 2015-02-17 f. Elliptic Curve Cryptography (ECC) Cipher Suites for Transport Layer Security (TLS) Versions 1.2 and Earlier

Alternative Fuels Data Center: Status Update: New Mid-Level Ethanol Blends

Science.gov Websites

differs from Subject 87A-E85 in several key ways. This new certification path only requires one test fluid , an aggressive E25 fluid, rather than both an E25 and an E85 test fluid. Due to the lack of contracted with UL to conduct these tests at their laboratory. NREL will test the dispensers using an

Phages of life - the path to pharma.

PubMed

Forde, Amanda; Hill, Colin

2018-02-01

Bacteriophage (phage) therapy has encountered both enthusiasm and scepticism in the past century. New antimicrobial strategies against lethal pathogens are now a top priority for the World Health Organization, and although compassionate use of phages recently met with significant success, regulated clinical interventions seem unlikely in the near future. The hundredth anniversary of their discovery seems an appropriate time for a revival of phage therapy, particularly as the dilemma of antibiotic resistance grows. Phages are ubiquitous in the environment, on our food and in and on our bodies. Their influence on human health is currently being evaluated, and in this mini-review, we examine data from recent metagenomic studies that propose a role for phages in the structure of the microbiome and in health and disease. We assess evidence for phages as vehicles for gene transfer in the context of antibiotic resistance and discuss challenges and opportunities along the critical path from phage discovery to a patient-focused pharmaceutical intervention. © 2017 The British Pharmacological Society.

Application of chemical biology in target identification and drug discovery.

PubMed

Zhu, Yue; Xiao, Ting; Lei, Saifei; Zhou, Fulai; Wang, Ming-Wei

2015-09-01

Drug discovery and development is vital to the well-being of mankind and sustainability of the pharmaceutical industry. Using chemical biology approaches to discover drug leads has become a widely accepted path partially because of the completion of the Human Genome Project. Chemical biology mainly solves biological problems through searching previously unknown targets for pharmacologically active small molecules or finding ligands for well-defined drug targets. It is a powerful tool to study how these small molecules interact with their respective targets, as well as their roles in signal transduction, molecular recognition and cell functions. There have been an increasing number of new therapeutic targets being identified and subsequently validated as a result of advances in functional genomics, which in turn led to the discovery of numerous active small molecules via a variety of high-throughput screening initiatives. In this review, we highlight some applications of chemical biology in the context of drug discovery.

The equivalence of learning paths in early science instruction: effect of direct instruction and discovery learning.

PubMed

Klahr, David; Nigam, Milena

2004-10-01

In a study with 112 third- and fourth-grade children, we measured the relative effectiveness of discovery learning and direct instruction at two points in the learning process: (a) during the initial acquisition of the basic cognitive objective (a procedure for designing and interpreting simple, unconfounded experiments) and (b) during the subsequent transfer and application of this basic skill to more diffuse and authentic reasoning associated with the evaluation of science-fair posters. We found not only that many more children learned from direct instruction than from discovery learning, but also that when asked to make broader, richer scientific judgments, the many children who learned about experimental design from direct instruction performed as well as those few children who discovered the method on their own. These results challenge predictions derived from the presumed superiority of discovery approaches in teaching young children basic procedures for early scientific investigations.

Halley's Comet Makes a Comeback.

ERIC Educational Resources Information Center

Glenn, William H.

1984-01-01

Presents information on Halley's Comet including its discovery, impact on history, planned investigations related to its 1986 return, where and when to make observations, and predicted calendar of events. Gives general information on comets such as physical structure, theoretical origin, and paths and provides an annotated reference list. (JM)

SemaTyP: a knowledge graph based literature mining method for drug discovery.

PubMed

Sang, Shengtian; Yang, Zhihao; Wang, Lei; Liu, Xiaoxia; Lin, Hongfei; Wang, Jian

2018-05-30

Drug discovery is the process through which potential new medicines are identified. High-throughput screening and computer-aided drug discovery/design are the two main drug discovery methods for now, which have successfully discovered a series of drugs. However, development of new drugs is still an extremely time-consuming and expensive process. Biomedical literature contains important clues for the identification of potential treatments. It could support experts in biomedicine on their way towards new discoveries. Here, we propose a biomedical knowledge graph-based drug discovery method called SemaTyP, which discovers candidate drugs for diseases by mining published biomedical literature. We first construct a biomedical knowledge graph with the relations extracted from biomedical abstracts, then a logistic regression model is trained by learning the semantic types of paths of known drug therapies' existing in the biomedical knowledge graph, finally the learned model is used to discover drug therapies for new diseases. The experimental results show that our method could not only effectively discover new drug therapies for new diseases, but also could provide the potential mechanism of action of the candidate drugs. In this paper we propose a novel knowledge graph based literature mining method for drug discovery. It could be a supplementary method for current drug discovery methods.

Windshear database for forward-looking systems certification

NASA Technical Reports Server (NTRS)

Switzer, G. F.; Proctor, F. H.; Hinton, D. A.; Aanstoos, J. V.

1993-01-01

This document contains a description of a comprehensive database that is to be used for certification testing of airborne forward-look windshear detection systems. The database was developed by NASA Langley Research Center, at the request of the Federal Aviation Administration (FAA), to support the industry initiative to certify and produce forward-look windshear detection equipment. The database contains high resolution, three dimensional fields for meteorological variables that may be sensed by forward-looking systems. The database is made up of seven case studies which have been generated by the Terminal Area Simulation System, a state-of-the-art numerical system for the realistic modeling of windshear phenomena. The selected cases represent a wide spectrum of windshear events. General descriptions and figures from each of the case studies are included, as well as equations for F-factor, radar-reflectivity factor, and rainfall rate. The document also describes scenarios and paths through the data sets, jointly developed by NASA and the FAA, to meet FAA certification testing objectives. Instructions for reading and verifying the data from tape are included.

From Residency to Lifelong Learning.

PubMed

Brandt, Keith

2015-11-01

The residency training experience is the perfect environment for learning. The university/institution patient population provides a never-ending supply of patients with unique management challenges. Resources abound that allow the discovery of knowledge about similar situations. Senior teachers provide counseling and help direct appropriate care. Periodic testing and evaluations identify deficiencies, which can be corrected with future study. What happens, however, when the resident graduates? Do they possess all the knowledge they'll need for the rest of their career? Will medical discovery stand still limiting the need for future study? If initial certification establishes that the physician has the skills and knowledge to function as an independent physician and surgeon, how do we assure the public that plastic surgeons will practice lifelong learning and remain safe throughout their career? Enter Maintenance of Certification (MOC). In an ideal world, MOC would provide many of the same tools as residency training: identification of gaps in knowledge, resources to correct those deficiencies, overall assessment of knowledge, feedback about communication skills and professionalism, and methods to evaluate and improve one's practice. This article discusses the need; for education and self-assessment that extends beyond residency training and a commitment to lifelong learning. The American Board of Plastic Surgery MOC program is described to demonstrate how it helps the diplomate reach the goal of continuous practice improvement.

Forty years of secondhand smoke research: the gap between discovery and delivery.

PubMed

Harris, Jenine K; Luke, Douglas A; Zuckerman, Rachael B; Shelton, Sarah C

2009-06-01

Public health initiatives often focus on the discovery of risk factors associated with disease and death. Although this is an important step in protecting public health, recently the field has recognized that it is critical to move along the continuum from discovery of risk factors to delivery of interventions, and to improve the quality and speed of translating scientific discoveries into practice. To understand how public health problems move from discovery to delivery, citation network analysis was used to examine 1877 articles on secondhand smoke (SHS) published between 1965 and 2005. Data were collected and analyzed in 2006-2007. Citation patterns showed discovery and delivery to be distinct areas of SHS research. There was little cross-citation between discovery and delivery research, including only nine citation connections between the main paths. A discovery article was 83.5% less likely to cite a delivery article than to cite another discovery article (OR=0.165 [95% CI=0.139, 0.197]), and a delivery article was 64.3% less likely (OR=0.357 [95% CI=0.330, 0.386]) to cite a discovery article than to cite another delivery article. Research summaries, such as Surgeon General reports, were cited frequently and appear to bridge the discovery-delivery gap. There was a lack of cross-citation between discovery and delivery, even though they share the goal of understanding and reducing the impact of SHS. Reliance on research summaries, although they provide an important bridge between discovery and delivery, may slow the development of a field.

Jupiter Quest: A Path to Scientific Discovery.

ERIC Educational Resources Information Center

Bollman, Kelly A.; Rodgers, Mark H.; Mauller, Robert L.

2001-01-01

To experience the world of professional science, students must have access to the scientific community and be allowed to become real scientists. A partnership involving the National Aeronautics and Space Administration, the Jet Propulsion Laboratory, and the Lewis Center for Educational Research has produced Jupiter Quest, an engaging curriculum…

A new lead to NLRP3 inhibition

PubMed Central

2017-01-01

The discovery of a small molecule inhibitor that targets the inflammasome sensor NLRP3 offers a new path for the development of selective inflammasome blockers with potential therapeutic benefit in a wide range of human diseases (in this issue, see Jiang et al., https://doi.org/10.1084/jem.20171419). PMID:29061692

Automated Discovery of Elementary Chemical Reaction Steps Using Freezing String and Berny Optimization Methods.

PubMed

Suleimanov, Yury V; Green, William H

2015-09-08

We present a simple protocol which allows fully automated discovery of elementary chemical reaction steps using in cooperation double- and single-ended transition-state optimization algorithms--the freezing string and Berny optimization methods, respectively. To demonstrate the utility of the proposed approach, the reactivity of several single-molecule systems of combustion and atmospheric chemistry importance is investigated. The proposed algorithm allowed us to detect without any human intervention not only "known" reaction pathways, manually detected in the previous studies, but also new, previously "unknown", reaction pathways which involve significant atom rearrangements. We believe that applying such a systematic approach to elementary reaction path finding will greatly accelerate the discovery of new chemistry and will lead to more accurate computer simulations of various chemical processes.

IMG-ABC: An Atlas of Biosynthetic Gene Clusters to Fuel the Discovery of Novel Secondary Metabolites

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chen, I-Min; Chu, Ken; Ratner, Anna

2014-10-28

In the discovery of secondary metabolites (SMs), large-scale analysis of sequence data is a promising exploration path that remains largely underutilized due to the lack of relevant computational resources. We present IMG-ABC (https://img.jgi.doe.gov/abc/) -- An Atlas of Biosynthetic gene Clusters within the Integrated Microbial Genomes (IMG) system1. IMG-ABC is a rich repository of both validated and predicted biosynthetic clusters (BCs) in cultured isolates, single-cells and metagenomes linked with the SM chemicals they produce and enhanced with focused analysis tools within IMG. The underlying scalable framework enables traversal of phylogenetic dark matter and chemical structure space -- serving as a doorwaymore » to a new era in the discovery of novel molecules.« less

Creative foraging: An experimental paradigm for studying exploration and discovery

PubMed Central

Mayo, Avraham E.; Mayo, Ruth; Rozenkrantz, Liron; Tendler, Avichai; Alon, Uri; Noy, Lior

2017-01-01

Creative exploration is central to science, art and cognitive development. However, research on creative exploration is limited by a lack of high-resolution automated paradigms. To address this, we present such an automated paradigm, the creative foraging game, in which people search for novel and valuable solutions in a large and well-defined space made of all possible shapes made of ten connected squares. Players discovered shape categories such as digits, letters, and airplanes as well as more abstract categories. They exploited each category, then dropped it to explore once again, and so on. Aligned with a prediction of optimal foraging theory (OFT), during exploration phases, people moved along meandering paths that are about three times longer than the shortest paths between shapes; when exploiting a category of related shapes, they moved along the shortest paths. The moment of discovery of a new category was usually done at a non-prototypical and ambiguous shape, which can serve as an experimental proxy for creative leaps. People showed individual differences in their search patterns, along a continuum between two strategies: a mercurial quick-to-discover/quick-to-drop strategy and a thorough slow-to-discover/slow-to-drop strategy. Contrary to optimal foraging theory, players leave exploitation to explore again far before categories are depleted. This paradigm opens the way for automated high-resolution study of creative exploration. PMID:28767668

Molpher: a software framework for systematic chemical space exploration

PubMed Central

2014-01-01

Background Chemical space is virtual space occupied by all chemically meaningful organic compounds. It is an important concept in contemporary chemoinformatics research, and its systematic exploration is vital to the discovery of either novel drugs or new tools for chemical biology. Results In this paper, we describe Molpher, an open-source framework for the systematic exploration of chemical space. Through a process we term ‘molecular morphing’, Molpher produces a path of structurally-related compounds. This path is generated by the iterative application of so-called ‘morphing operators’ that represent simple structural changes, such as the addition or removal of an atom or a bond. Molpher incorporates an optimized parallel exploration algorithm, compound logging and a two-dimensional visualization of the exploration process. Its feature set can be easily extended by implementing additional morphing operators, chemical fingerprints, similarity measures and visualization methods. Molpher not only offers an intuitive graphical user interface, but also can be run in batch mode. This enables users to easily incorporate molecular morphing into their existing drug discovery pipelines. Conclusions Molpher is an open-source software framework for the design of virtual chemical libraries focused on a particular mechanistic class of compounds. These libraries, represented by a morphing path and its surroundings, provide valuable starting data for future in silico and in vitro experiments. Molpher is highly extensible and can be easily incorporated into any existing computational drug design pipeline. PMID:24655571

Molpher: a software framework for systematic chemical space exploration.

PubMed

Hoksza, David; Skoda, Petr; Voršilák, Milan; Svozil, Daniel

2014-03-21

Chemical space is virtual space occupied by all chemically meaningful organic compounds. It is an important concept in contemporary chemoinformatics research, and its systematic exploration is vital to the discovery of either novel drugs or new tools for chemical biology. In this paper, we describe Molpher, an open-source framework for the systematic exploration of chemical space. Through a process we term 'molecular morphing', Molpher produces a path of structurally-related compounds. This path is generated by the iterative application of so-called 'morphing operators' that represent simple structural changes, such as the addition or removal of an atom or a bond. Molpher incorporates an optimized parallel exploration algorithm, compound logging and a two-dimensional visualization of the exploration process. Its feature set can be easily extended by implementing additional morphing operators, chemical fingerprints, similarity measures and visualization methods. Molpher not only offers an intuitive graphical user interface, but also can be run in batch mode. This enables users to easily incorporate molecular morphing into their existing drug discovery pipelines. Molpher is an open-source software framework for the design of virtual chemical libraries focused on a particular mechanistic class of compounds. These libraries, represented by a morphing path and its surroundings, provide valuable starting data for future in silico and in vitro experiments. Molpher is highly extensible and can be easily incorporated into any existing computational drug design pipeline.

An Energy-Efficient and Robust Multipath Routing Protocol for Cognitive Radio Ad Hoc Networks.

PubMed

Singh, Kishor; Moh, Sangman

2017-09-04

Routing in cognitive radio ad hoc networks (CRAHNs) is a daunting task owing to dynamic topology, intermittent connectivity, spectrum heterogeneity, and energy constraints. Other prominent aspects such as channel stability, path reliability, and route discovery frequency should also be exploited. Several routing protocols have been proposed for CRAHNs in the literature. By stressing on one of the aspects more than any other, however, they do not satisfy all requirements of throughput, energy efficiency, and robustness. In this paper, we propose an energy-efficient and robust multipath routing (ERMR) protocol for CRAHNs by considering all prominent aspects including residual energy and channel stability in design. Even when the current routing path fails, the alternative routing path is immediately utilized. In establishing primary and alternative routing paths, both residual energy and channel stability are exploited simultaneously. Our simulation study shows that the proposed ERMR outperforms the conventional protocol in terms of network throughput, packet delivery ratio, energy consumption, and end-to-end delay.

An Energy-Efficient and Robust Multipath Routing Protocol for Cognitive Radio Ad Hoc Networks

PubMed Central

Singh, Kishor

2017-01-01

Routing in cognitive radio ad hoc networks (CRAHNs) is a daunting task owing to dynamic topology, intermittent connectivity, spectrum heterogeneity, and energy constraints. Other prominent aspects such as channel stability, path reliability, and route discovery frequency should also be exploited. Several routing protocols have been proposed for CRAHNs in the literature. By stressing on one of the aspects more than any other, however, they do not satisfy all requirements of throughput, energy efficiency, and robustness. In this paper, we propose an energy-efficient and robust multipath routing (ERMR) protocol for CRAHNs by considering all prominent aspects including residual energy and channel stability in design. Even when the current routing path fails, the alternative routing path is immediately utilized. In establishing primary and alternative routing paths, both residual energy and channel stability are exploited simultaneously. Our simulation study shows that the proposed ERMR outperforms the conventional protocol in terms of network throughput, packet delivery ratio, energy consumption, and end-to-end delay. PMID:28869551

Found in Translation: What’s going on at the USDA’s Beltsville Bee Research Laboratory

USDA-ARS?s Scientific Manuscript database

Practical research discoveries follow a twisting path. Basic research driven by the human need to understand nature can, often years or even decades later, lead to huge advances that benefit people or the environment. Alternatively, sure-thing tests of a new product, management strategy, or breeding...

Montessori(TM) Math by Colors [CD Rom.

ERIC Educational Resources Information Center

1995

Montessori(TM) Learning Software programs are purportedly built upon the core concept of the Montessori philosophy, that a major path to intellectual development is through a child's hands and senses. Math by Colors, recommended for ages 4 to 8, encourages hands-on discovery by allowing the child to choose the right color from the assembled paint…

Rediscovering Pascal's Mystic Hexagon

ERIC Educational Resources Information Center

Augros, Michael

2012-01-01

While the path to mathematical discovery is often intuitive and not simply reducible to the application of a method, neither is it in most cases entirely haphazard. Certain kinds of questions and certain ways of looking at things tend to produce new and interesting results. To illustrate, this paper tells a story of how someone might discover…

The Path of Many Journeys: The Benefits of Higher Education for Native People and Communities

ERIC Educational Resources Information Center

Institute for Higher Education Policy, 2007

2007-01-01

The economic and cultural plight of American Indians began when the first White settlers landed on the shores of North America. For American Indians, the "discovery" of America was the beginning of cultural and physical destruction, marginalization, discrimination, and impoverishment. The resulting gap between American Indians and mainstream…

A new lead to NLRP3 inhibition.

PubMed

Lamkanfi, Mohamed; Dixit, Vishva M

2017-11-06

The discovery of a small molecule inhibitor that targets the inflammasome sensor NLRP3 offers a new path for the development of selective inflammasome blockers with potential therapeutic benefit in a wide range of human diseases (in this issue, see Jiang et al., https://doi.org/10.1084/jem.20171419). © 2017 Lamkanfi and Dixit.

The Spider and the Fly

ERIC Educational Resources Information Center

Mellinger, Keith E.; Viglione, Raymond

2012-01-01

The Spider and the Fly puzzle, originally attributed to the great puzzler Henry Ernest Dudeney, and now over 100 years old, asks for the shortest path between two points on a particular square prism. We explore a generalization, find that the original solution only holds in certain cases, and suggest how this discovery might be used in the…

Many Paths toward Discovery: A Module for Teaching How Science Works

ERIC Educational Resources Information Center

Price, Rebecca M.; Perez, Kathryn E.

2018-01-01

Improving students' understanding of how science works requires explicit instruction. Here, we test the efficacy of a module based on two previously published activities (the "Cube Puzzle" and the case study "Asteroids and Dinosaurs") that teach how science works to college science majors. Students also use the How Science…

University of Washington's eScience Institute Promotes New Training and Career Pathways in Data Science

NASA Astrophysics Data System (ADS)

Stone, S.; Parker, M. S.; Howe, B.; Lazowska, E.

2015-12-01

Rapid advances in technology are transforming nearly every field from "data-poor" to "data-rich." The ability to extract knowledge from this abundance of data is the cornerstone of 21st century discovery. At the University of Washington eScience Institute, our mission is to engage researchers across disciplines in developing and applying advanced computational methods and tools to real world problems in data-intensive discovery. Our research team consists of individuals with diverse backgrounds in domain sciences such as astronomy, oceanography and geology, with complementary expertise in advanced statistical and computational techniques such as data management, visualization, and machine learning. Two key elements are necessary to foster careers in data science: individuals with cross-disciplinary training in both method and domain sciences, and career paths emphasizing alternative metrics for advancement. We see persistent and deep-rooted challenges for the career paths of people whose skills, activities and work patterns don't fit neatly into the traditional roles and success metrics of academia. To address these challenges the eScience Institute has developed training programs and established new career opportunities for data-intensive research in academia. Our graduate students and post-docs have mentors in both a methodology and an application field. They also participate in coursework and tutorials to advance technical skill and foster community. Professional Data Scientist positions were created to support research independence while encouraging the development and adoption of domain-specific tools and techniques. The eScience Institute also supports the appointment of faculty who are innovators in developing and applying data science methodologies to advance their field of discovery. Our ultimate goal is to create a supportive environment for data science in academia and to establish global recognition for data-intensive discovery across all fields.

Intelligent routing protocol for ad hoc wireless network

NASA Astrophysics Data System (ADS)

Peng, Chaorong; Chen, Chang Wen

2006-05-01

A novel routing scheme for mobile ad hoc networks (MANETs), which combines hybrid and multi-inter-routing path properties with a distributed topology discovery route mechanism using control agents is proposed in this paper. In recent years, a variety of hybrid routing protocols for Mobile Ad hoc wireless networks (MANETs) have been developed. Which is proactively maintains routing information for a local neighborhood, while reactively acquiring routes to destinations beyond the global. The hybrid protocol reduces routing discovery latency and the end-to-end delay by providing high connectivity without requiring much of the scarce network capacity. On the other side the hybrid routing protocols in MANETs likes Zone Routing Protocol still need route "re-discover" time when a route between zones link break. Sine the topology update information needs to be broadcast routing request on local zone. Due to this delay, the routing protocol may not be applicable for real-time data and multimedia communication. We utilize the advantages of a clustering organization and multi-routing path in routing protocol to achieve several goals at the same time. Firstly, IRP efficiently saves network bandwidth and reduces route reconstruction time when a routing path fails. The IRP protocol does not require global periodic routing advertisements, local control agents will automatically monitor and repair broke links. Secondly, it efficiently reduces congestion and traffic "bottlenecks" for ClusterHeads in clustering network. Thirdly, it reduces significant overheads associated with maintaining clusters. Fourthly, it improves clusters stability due to dynamic topology changing frequently. In this paper, we present the Intelligent Routing Protocol. First, we discuss the problem of routing in ad hoc networks and the motivation of IRP. We describe the hierarchical architecture of IRP. We describe the routing process and illustrate it with an example. Further, we describe the control manage mechanisms, which are used to control active route and reduce the traffic amount in the route discovery procedure. Finial, the numerical experiments are given to show the effectiveness of IRP routing protocol.

A collaborative network middleware project by Lambda Station, TeraPaths, and Phoebus

NASA Astrophysics Data System (ADS)

Bobyshev, A.; Bradley, S.; Crawford, M.; DeMar, P.; Katramatos, D.; Shroff, K.; Swany, M.; Yu, D.

2010-04-01

The TeraPaths, Lambda Station, and Phoebus projects, funded by the US Department of Energy, have successfully developed network middleware services that establish on-demand and manage true end-to-end, Quality-of-Service (QoS) aware, virtual network paths across multiple administrative network domains, select network paths and gracefully reroute traffic over these dynamic paths, and streamline traffic between packet and circuit networks using transparent gateways. These services improve network QoS and performance for applications, playing a critical role in the effective use of emerging dynamic circuit network services. They provide interfaces to applications, such as dCache SRM, translate network service requests into network device configurations, and coordinate with each other to setup up end-to-end network paths. The End Site Control Plane Subsystem (ESCPS) builds upon the success of the three projects by combining their individual capabilities into the next generation of network middleware. ESCPS addresses challenges such as cross-domain control plane signalling and interoperability, authentication and authorization in a Grid environment, topology discovery, and dynamic status tracking. The new network middleware will take full advantage of the perfSONAR monitoring infrastructure and the Inter-Domain Control plane efforts and will be deployed and fully vetted in the Large Hadron Collider data movement environment.

Energy-Aware Multipath Routing Scheme Based on Particle Swarm Optimization in Mobile Ad Hoc Networks

PubMed Central

Robinson, Y. Harold; Rajaram, M.

2015-01-01

Mobile ad hoc network (MANET) is a collection of autonomous mobile nodes forming an ad hoc network without fixed infrastructure. Dynamic topology property of MANET may degrade the performance of the network. However, multipath selection is a great challenging task to improve the network lifetime. We proposed an energy-aware multipath routing scheme based on particle swarm optimization (EMPSO) that uses continuous time recurrent neural network (CTRNN) to solve optimization problems. CTRNN finds the optimal loop-free paths to solve link disjoint paths in a MANET. The CTRNN is used as an optimum path selection technique that produces a set of optimal paths between source and destination. In CTRNN, particle swarm optimization (PSO) method is primly used for training the RNN. The proposed scheme uses the reliability measures such as transmission cost, energy factor, and the optimal traffic ratio between source and destination to increase routing performance. In this scheme, optimal loop-free paths can be found using PSO to seek better link quality nodes in route discovery phase. PSO optimizes a problem by iteratively trying to get a better solution with regard to a measure of quality. The proposed scheme discovers multiple loop-free paths by using PSO technique. PMID:26819966

Civil helicopter noise assessment study Boeing-Vertol model 347. [recommendations for reduction of helicopter noise levels

NASA Technical Reports Server (NTRS)

Hinterkeuser, E. G.; Sternfeld, H., Jr.

1974-01-01

A study was conducted to forecast the noise restrictions which may be imposed on civil transport helicopters in the 1975-1985 time period. Certification and community acceptance criteria were predicted. A 50 passenger tandem rotor helicopter based on the Boeing-Vertol Model 347 was studied to determine the noise reductions required, and the means of achieving them. Some of the important study recommendations are: (1) certification limits should be equivalent to 95 EPNdb at data points located at 500 feet to each side of the touchdown/takeoff point, and 1000 feet from this point directly under the approach and departure flight path. (2) community acceptance should be measured as Equivalent Noise Level (Leq), based on dBA, with separate limits for day and night operations, and (3) in order to comply with the above guidelines, the Model 347 helicopter will require studies and tests leading to several modifications.

Distributed Trust Evaluation in Ad-Hoc Networks

DTIC Science & Technology

2004-01-01

of money that the issuer will pay to anyone who is misled because of the certificate. Being misled means falsely authenticating the certified entity...Alice to Bob. This is the minimum amount of money for which Alice is insured in the case of her being misled by Bob’s key. Note that if all edges are...confidence gets to vote first. Moreover, some paths are pruned which means that fewer messages are exchanged, thus saving bandwidth, but also some of the

Discover for Yourself: An Optimal Control Model in Insect Colonies

ERIC Educational Resources Information Center

Winkel, Brian

2013-01-01

We describe the enlightening path of self-discovery afforded to the teacher of undergraduate mathematics. This is demonstrated as we find and develop background material on an application of optimal control theory to model the evolutionary strategy of an insect colony to produce the maximum number of queen or reproducer insects in the colony at…

Visual Reasoning in Computational Environment: A Case of Graph Sketching

ERIC Educational Resources Information Center

Leung, Allen; Chan, King Wah

2004-01-01

This paper reports the case of a form six (grade 12) Hong Kong student's exploration of graph sketching in a computational environment. In particular, the student summarized his discovery in the form of two empirical laws. The student was interviewed and the interviewed data were used to map out a possible path of his visual reasoning. Critical…

Nuclear Winter: Scientists in the Political Arena

NASA Astrophysics Data System (ADS)

Badash, Lawrence

2001-03-01

The nuclear winter phenomenon is used to illustrate the many paths by which scientific advice reaches decision makers in the United States government. Because the Reagan administration was hostile to the strategic policy that the scientific discovery seemed to demand, the leading proponent of nuclear winter, Carl Sagan, used his formidable talent for popularization to reach a larger audience.

Historical milestones and discoveries that shaped the toxicology sciences.

PubMed

Hayes, Antoinette N; Gilbert, Steven G

2009-01-01

Knowledge of the toxic and healing properties of plants, animals, and minerals has shaped civilization for millennia. The foundations of modern toxicology are built upon the significant milestones and discoveries of serendipity and crude experimentation. Throughout the ages, toxicological science has provided information that has shaped and guided society. This chapter examines the development of the discipline of toxicology and its influence on civilization by highlighting significant milestones and discoveries related to toxicology. The examples shed light on the beginnings of toxicology, as well as examine lessons learned and re-learned. This chapter also examines how toxicology and the toxicologist have interacted with other scientific and cultural disciplines, including religion, politics, and the government. Toxicology has evolved to a true scientific discipline with its own dedicated scientists, educational institutes, sub-disciplines, professional societies, and journals. It now stands as its own entity while traversing such fields as chemistry, physiology, pharmacology, and molecular biology. We invite you to join us on a path of discovery and to offer our suggestions as to what are the most significant milestones and discoveries in toxicology. Additional information is available on the history section of Toxipedia (www.toxipedia.org).

Verification and Validation Challenges for Adaptive Flight Control of Complex Autonomous Systems

NASA Technical Reports Server (NTRS)

Nguyen, Nhan T.

2018-01-01

Autonomy of aerospace systems requires the ability for flight control systems to be able to adapt to complex uncertain dynamic environment. In spite of the five decades of research in adaptive control, the fact still remains that currently no adaptive control system has ever been deployed on any safety-critical or human-rated production systems such as passenger transport aircraft. The problem lies in the difficulty with the certification of adaptive control systems since existing certification methods cannot readily be used for nonlinear adaptive control systems. Research to address the notion of metrics for adaptive control began to appear in the recent years. These metrics, if accepted, could pave a path towards certification that would potentially lead to the adoption of adaptive control as a future control technology for safety-critical and human-rated production systems. Development of certifiable adaptive control systems represents a major challenge to overcome. Adaptive control systems with learning algorithms will never become part of the future unless it can be proven that they are highly safe and reliable. Rigorous methods for adaptive control software verification and validation must therefore be developed to ensure that adaptive control system software failures will not occur, to verify that the adaptive control system functions as required, to eliminate unintended functionality, and to demonstrate that certification requirements imposed by regulatory bodies such as the Federal Aviation Administration (FAA) can be satisfied. This presentation will discuss some of the technical issues with adaptive flight control and related V&V challenges.

Graph theory enables drug repurposing--how a mathematical model can drive the discovery of hidden mechanisms of action.

PubMed

Gramatica, Ruggero; Di Matteo, T; Giorgetti, Stefano; Barbiani, Massimo; Bevec, Dorian; Aste, Tomaso

2014-01-01

We introduce a methodology to efficiently exploit natural-language expressed biomedical knowledge for repurposing existing drugs towards diseases for which they were not initially intended. Leveraging on developments in Computational Linguistics and Graph Theory, a methodology is defined to build a graph representation of knowledge, which is automatically analysed to discover hidden relations between any drug and any disease: these relations are specific paths among the biomedical entities of the graph, representing possible Modes of Action for any given pharmacological compound. We propose a measure for the likeliness of these paths based on a stochastic process on the graph. This measure depends on the abundance of indirect paths between a peptide and a disease, rather than solely on the strength of the shortest path connecting them. We provide real-world examples, showing how the method successfully retrieves known pathophysiological Mode of Action and finds new ones by meaningfully selecting and aggregating contributions from known bio-molecular interactions. Applications of this methodology are presented, and prove the efficacy of the method for selecting drugs as treatment options for rare diseases.

Exploiting microRNA Specificity and Selectivity: Paving a Sustainable Path Towards Precision Medicine.

PubMed

Santulli, Gaetano

2015-01-01

In his State of the Union address before both chambers of the US Congress, President Barack Obama called for increased investment in US infrastructure and research and announced the launch of a new Precision Medicine Initiative, aiming to accelerate biomedical discovery. Due to their well-established selectivity and specificity, microRNAs can represent a useful tool, both in diagnosis and therapy, in forging the path towards the achievement of precision medicine. This introductory chapter represents a guide for the Reader in examining the functional roles of microRNAs in the most diverse aspects of clinical practice, which will be explored in this third volume of the microRNA trilogy.

Exploiting microRNA Specificity and Selectivity: Paving a Sustainable Path Towards Precision Medicine

PubMed Central

2016-01-01

In his State of the Union address before both chambers of the US Congress, President Barack Obama called for increased investment in US infrastructure and research and announced the launch of a new Precision Medicine Initiative, aiming to accelerate biomedical discovery. Due to their well-established selectivity and specificity, microRNAs can represent a useful tool, both in diagnosis and therapy, in forging the path towards the achievement of precision medicine. This introductory chapter represents a guide for the Reader in examining the functional roles of microRNAs in the most diverse aspects of clinical practice, which will be explored in this third volume of the microRNA trilogy. PMID:26663175

Building a Path to College Success: Advocacy, Discovery and OER Adoption in Emerging Educational Models

ERIC Educational Resources Information Center

Woodward, Kristin M.

2017-01-01

In this case study we will examine the role of the library in Open Educational Resources through the lens of library value described in Megan Oakleaf's 2010 ACRL [Association of College and Research Libraries] report. While librarians in our organization have traditionally not played a role in textbook adoptions, the campus academic goal to…

Wireless Distribution Systems To Support Medical Response to Disasters

PubMed Central

Arisoylu, Mustafa; Mishra, Rajesh; Rao, Ramesh; Lenert, Leslie A.

2005-01-01

We discuss the design of multi-hop access networks with multiple gateways that supports medical response to disasters. We examine and implement protocols to ensure high bandwidth, robust, self-healing and secure wireless multi-hop access networks for extreme conditions. Address management, path setup, gateway discovery and selection protocols are described. Future directions and plans are also considered. PMID:16779171

Improving Upon String Methods for Transition State Discovery.

PubMed

Chaffey-Millar, Hugh; Nikodem, Astrid; Matveev, Alexei V; Krüger, Sven; Rösch, Notker

2012-02-14

Transition state discovery via application of string methods has been researched on two fronts. The first front involves development of a new string method, named the Searching String method, while the second one aims at estimating transition states from a discretized reaction path. The Searching String method has been benchmarked against a number of previously existing string methods and the Nudged Elastic Band method. The developed methods have led to a reduction in the number of gradient calls required to optimize a transition state, as compared to existing methods. The Searching String method reported here places new beads on a reaction pathway at the midpoint between existing beads, such that the resolution of the path discretization in the region containing the transition state grows exponentially with the number of beads. This approach leads to favorable convergence behavior and generates more accurate estimates of transition states from which convergence to the final transition states occurs more readily. Several techniques for generating improved estimates of transition states from a converged string or nudged elastic band have been developed and benchmarked on 13 chemical test cases. Optimization approaches for string methods, and pitfalls therein, are discussed.

Discovery of new candidate genes related to brain development using protein interaction information.

PubMed

Chen, Lei; Chu, Chen; Kong, Xiangyin; Huang, Tao; Cai, Yu-Dong

2015-01-01

Human brain development is a dramatic process composed of a series of complex and fine-tuned spatiotemporal gene expressions. A good comprehension of this process can assist us in developing the potential of our brain. However, we have only limited knowledge about the genes and gene functions that are involved in this biological process. Therefore, a substantial demand remains to discover new brain development-related genes and identify their biological functions. In this study, we aimed to discover new brain-development related genes by building a computational method. We referred to a series of computational methods used to discover new disease-related genes and developed a similar method. In this method, the shortest path algorithm was executed on a weighted graph that was constructed using protein-protein interactions. New candidate genes fell on at least one of the shortest paths connecting two known genes that are related to brain development. A randomization test was then adopted to filter positive discoveries. Of the final identified genes, several have been reported to be associated with brain development, indicating the effectiveness of the method, whereas several of the others may have potential roles in brain development.

Handling Neighbor Discovery and Rendezvous Consistency with Weighted Quorum-Based Approach

PubMed Central

Own, Chung-Ming; Meng, Zhaopeng; Liu, Kehan

2015-01-01

Neighbor discovery and the power of sensors play an important role in the formation of Wireless Sensor Networks (WSNs) and mobile networks. Many asynchronous protocols based on wake-up time scheduling have been proposed to enable neighbor discovery among neighboring nodes for the energy saving, especially in the difficulty of clock synchronization. However, existing researches are divided two parts with the neighbor-discovery methods, one is the quorum-based protocols and the other is co-primality based protocols. Their distinction is on the arrangements of time slots, the former uses the quorums in the matrix, the latter adopts the numerical analysis. In our study, we propose the weighted heuristic quorum system (WQS), which is based on the quorum algorithm to eliminate redundant paths of active slots. We demonstrate the specification of our system: fewer active slots are required, the referring rate is balanced, and remaining power is considered particularly when a device maintains rendezvous with discovered neighbors. The evaluation results showed that our proposed method can effectively reschedule the active slots and save the computing time of the network system. PMID:26404297

Service-based analysis of biological pathways

PubMed Central

Zheng, George; Bouguettaya, Athman

2009-01-01

Background Computer-based pathway discovery is concerned with two important objectives: pathway identification and analysis. Conventional mining and modeling approaches aimed at pathway discovery are often effective at achieving either objective, but not both. Such limitations can be effectively tackled leveraging a Web service-based modeling and mining approach. Results Inspired by molecular recognitions and drug discovery processes, we developed a Web service mining tool, named PathExplorer, to discover potentially interesting biological pathways linking service models of biological processes. The tool uses an innovative approach to identify useful pathways based on graph-based hints and service-based simulation verifying user's hypotheses. Conclusion Web service modeling of biological processes allows the easy access and invocation of these processes on the Web. Web service mining techniques described in this paper enable the discovery of biological pathways linking these process service models. Algorithms presented in this paper for automatically highlighting interesting subgraph within an identified pathway network enable the user to formulate hypothesis, which can be tested out using our simulation algorithm that are also described in this paper. PMID:19796403

Drug discovery in the next millennium.

PubMed

Ohlstein, E H; Ruffolo, R R; Elliott, J D

2000-01-01

Selection and validation of novel molecular targets have become of paramount importance in light of the plethora of new potential therapeutic drug targets that have emerged from human gene sequencing. In response to this revolution within the pharmaceutical industry, the development of high-throughput methods in both biology and chemistry has been necessitated. This review addresses these technological advances as well as several new areas that have been created by necessity to deal with this new paradigm, such as bioinformatics, cheminformatics, and functional genomics. With many of these key components of future drug discovery now in place, it is possible to map out a critical path for this process that will be used into the new millennium.

EuPathDB: the eukaryotic pathogen genomics database resource

PubMed Central

Aurrecoechea, Cristina; Barreto, Ana; Basenko, Evelina Y.; Brestelli, John; Brunk, Brian P.; Cade, Shon; Crouch, Kathryn; Doherty, Ryan; Falke, Dave; Fischer, Steve; Gajria, Bindu; Harb, Omar S.; Heiges, Mark; Hertz-Fowler, Christiane; Hu, Sufen; Iodice, John; Kissinger, Jessica C.; Lawrence, Cris; Li, Wei; Pinney, Deborah F.; Pulman, Jane A.; Roos, David S.; Shanmugasundram, Achchuthan; Silva-Franco, Fatima; Steinbiss, Sascha; Stoeckert, Christian J.; Spruill, Drew; Wang, Haiming; Warrenfeltz, Susanne; Zheng, Jie

2017-01-01

The Eukaryotic Pathogen Genomics Database Resource (EuPathDB, http://eupathdb.org) is a collection of databases covering 170+ eukaryotic pathogens (protists & fungi), along with relevant free-living and non-pathogenic species, and select pathogen hosts. To facilitate the discovery of meaningful biological relationships, the databases couple preconfigured searches with visualization and analysis tools for comprehensive data mining via intuitive graphical interfaces and APIs. All data are analyzed with the same workflows, including creation of gene orthology profiles, so data are easily compared across data sets, data types and organisms. EuPathDB is updated with numerous new analysis tools, features, data sets and data types. New tools include GO, metabolic pathway and word enrichment analyses plus an online workspace for analysis of personal, non-public, large-scale data. Expanded data content is mostly genomic and functional genomic data while new data types include protein microarray, metabolic pathways, compounds, quantitative proteomics, copy number variation, and polysomal transcriptomics. New features include consistent categorization of searches, data sets and genome browser tracks; redesigned gene pages; effective integration of alternative transcripts; and a EuPathDB Galaxy instance for private analyses of a user's data. Forthcoming upgrades include user workspaces for private integration of data with existing EuPathDB data and improved integration and presentation of host–pathogen interactions. PMID:27903906

Precompetitive Data Sharing as a Catalyst to Address Unmet Needs in Parkinson’s Disease 1

PubMed Central

Stephenson, Diane; Hu, Michele T.; Romero, Klaus; Breen, Kieran; Burn, David; Ben-Shlomo, Yoav; Bhattaram, Atul; Isaac, Maria; Venuto, Charles; Kubota, Ken; Little, Max A.; Friend, Stephen; Lovestone, Simon; Morris, Huw R.; Grosset, Donald; Sutherland, Margaret; Gallacher, John; Williams-Gray, Caroline; Bain, Lisa J.; Avilés, Enrique; Marek, Ken; Toga, Arthur W.; Stark, Yafit; Forrest Gordon, Mark; Ford, Steve

2015-01-01

Abstract Parkinson’s disease is a complex heterogeneous disorder with urgent need for disease-modifying therapies. Progress in successful therapeutic approaches for PD will require an unprecedented level of collaboration. At a workshop hosted by Parkinson’s UK and co-organized by Critical Path Institute’s (C-Path) Coalition Against Major Diseases (CAMD) Consortiums, investigators from industry, academia, government and regulatory agencies agreed on the need for sharing of data to enable future success. Government agencies included EMA, FDA, NINDS/NIH and IMI (Innovative Medicines Initiative). Emerging discoveries in new biomarkers and genetic endophenotypes are contributing to our understanding of the underlying pathophysiology of PD. In parallel there is growing recognition that early intervention will be key for successful treatments aimed at disease modification. At present, there is a lack of a comprehensive understanding of disease progression and the many factors that contribute to disease progression heterogeneity. Novel therapeutic targets and trial designs that incorporate existing and new biomarkers to evaluate drug effects independently and in combination are required. The integration of robust clinical data sets is viewed as a powerful approach to hasten medical discovery and therapies, as is being realized across diverse disease conditions employing big data analytics for healthcare. The application of lessons learned from parallel efforts is critical to identify barriers and enable a viable path forward. A roadmap is presented for a regulatory, academic, industry and advocacy driven integrated initiative that aims to facilitate and streamline new drug trials and registrations in Parkinson’s disease. PMID:26406139

Consolidated Afloat Networks and Enterprise Services (CANES). Manpower, Personnel, and Training Implications

DTIC Science & Technology

2009-01-01

certification and proceed to a unit. They are represented in the stock “Later pass to 4YOS ,” and the rest of their career follows the same path as ITs who...In the Status Quo and the Base Case, all ITs enter on a four-years-of-service ( 4YOS ) contract. In Case 1, which reflects current plans for ITs, the...IT community is split between those entering with 4YOS and those entering with 6YOS contracts. Thirty-five percent of the community enters with a

Eighth triennial toxicology salary survey.

PubMed

Gad, Shayne Cox; Sullivan, Dexter Wayne

2013-01-01

This survey serves as the eighth in a series of toxicology salary surveys conducted at 3-year intervals and beginning in 1988. An electronic survey instrument was distributed to 5800 individuals including members of the Society of Toxicology, American College of Toxicology, and 23 additional professional organizations. Question items inquired about gender, age, degree, years of experience, certifications held, areas of specialization, society membership, employment and income. Overall, 2057 responses were received (response rate 35.5%). The results of the 2012 survey provide insight into the job market and career path for current and future toxicologists.

Investigations of Shuttle Main Landing Gear Door Environmental Seals

NASA Technical Reports Server (NTRS)

Finkbeiner, Joshua; Dunlap, Pat; Steinetz, Bruce; DeMango, Jeff; Newswander, Daniel

2005-01-01

The environmental seals for the main landing gear doors of the Shuttle Orbiters were raised by the Columbia Accident Investigation Board as a potential safety concern. Inspections of seals installed on the Shuttle Discovery revealed that they were permanently deformed and no longer met certified seal compression requirements. Replacement of the seals led to the inability to fully close the main landing gear doors. Johnson Space Center requested that Glenn Research Center conduct tests on the main landing gear door environmental seals to assist in installing the seals in a manner to allow the main landing gear doors to fully close. Further testing was conducted to fill out the seal performance database. Results from the testing indicated that the method of bonding the seals was important in reducing seal loads on the main landing gear doors. Also, the replacement seals installed in Shuttle Discovery were found to have leakage performance sufficient to meet the certification requirements.

Learning from the unexpected in life and DNA self-assembly

PubMed Central

2015-01-01

Summary The greatest lessons in life and science often arise from the unexpected. Thus, rather than viewing these experiences as hindering our progress, they should be embraced and appreciated for their ability to lead to new discoveries. In this perspective, I will discuss the unexpected events that have shaped my career path and the early stages of my independent research program. PMID:26877793

UAS-Systems Integration, Validation, and Diagnostics Simulation Capability

NASA Technical Reports Server (NTRS)

Buttrill, Catherine W.; Verstynen, Harry A.

2014-01-01

As part of the Phase 1 efforts of NASA's UAS-in-the-NAS Project a task was initiated to explore the merits of developing a system simulation capability for UAS to address airworthiness certification requirements. The core of the capability would be a software representation of an unmanned vehicle, including all of the relevant avionics and flight control system components. The specific system elements could be replaced with hardware representations to provide Hardware-in-the-Loop (HWITL) test and evaluation capability. The UAS Systems Integration and Validation Laboratory (UAS-SIVL) was created to provide a UAS-systems integration, validation, and diagnostics hardware-in-the-loop simulation capability. This paper discusses how SIVL provides a robust and flexible simulation framework that permits the study of failure modes, effects, propagation paths, criticality, and mitigation strategies to help develop safety, reliability, and design data that can assist with the development of certification standards, means of compliance, and design best practices for civil UAS.

Catalysts for Change: The Role of Small Business Funders in the Creation and Dissemination of Innovation

PubMed Central

Shic, Frederick; Smith, Daniel; Horsburgh, Brian; Hollander, Eric; Rehg, James M.; Goodwin, Matthew

2015-01-01

A gap exists between the expanding space of technological innovations to aid those affected by autism spectrum disorders, and the actual impact of those technologies on daily lives. This gap can be addressed through a very practical path of commercialization. However, the path from a technological innovation to a commercially viable product is fraught with challenges. These challenges can be mitigated through small business funding agencies, which are, more and more, catalyzing the dissemination of innovation by fostering social entrepreneurship through capital support and venture philanthropy. This letter describes the differences and nature of these agencies, and their importance in facilitating the translational and real-world impact of technological and scientific discoveries. PMID:26481385

Catalysts for Change: The Role of Small Business Funders in the Creation and Dissemination of Innovation.

PubMed

Shic, Frederick; Smith, Daniel; Horsburgh, Brian; Hollander, Eric; Rehg, James M; Goodwin, Matthew

2015-12-01

A gap exists between the expanding space of technological innovations to aid those affected by autism spectrum disorders, and the actual impact of those technologies on daily lives. This gap can be addressed through a very practical path of commercialization. However, the path from a technological innovation to a commercially viable product is fraught with challenges. These challenges can be mitigated through small business funding agencies, which are, more and more, catalyzing the dissemination of innovation by fostering social entrepreneurship through capital support and venture philanthropy. This letter describes the differences and nature of these agencies, and their importance in facilitating the translational and real-world impact of technological and scientific discoveries.

High temperature unfolding of a truncated hemoglobin by molecular dynamics simulation.

PubMed

Sharma, Ravi Datta; Kanwal, Rajnee; Lynn, Andrew M; Singh, Prerna; Pasha, Syed Tazeen; Fatma, Tasneem; Jawaid, Safdar

2013-09-01

Heme containing proteins are associated with peroxidase activity. The proteins like hemoglobin, myoglobins, cytochrome c and micro-peroxidase other than peroxidases have been shown to exhibit weak peroxidase-like activity. This weak peroxidase-like activity in hemoglobin-like molecules is due to heme moiety. We conducted molecular dynamics (MD) studies to decipher the unfolding path of Ba-Glb (a truncated hemoglobin from Bacillus anthracis) and the role of heme moiety to its unfolding path. The similar unfolding path is also observed in vitro by UV/VIS spectroscopy. The data confirmed that the unfolding of Ba-Glb follows a three state process with a meta-stable (intermediate) state between the native and unfolded conformations. The present study is supported by several unfolding parameters like root-mean-square-deviation (RMSD), dictionary of protein secondary structure (DSSP), and free energy landscape. Understanding the structure of hemoglobin like proteins in unicellular dreaded pathogens like B. anthracis will pave way for newer drug discovery targets and in the disease management of anthrax.

Solving the detour problem in navigation: a model of prefrontal and hippocampal interactions.

PubMed

Spiers, Hugo J; Gilbert, Sam J

2015-01-01

Adapting behavior to accommodate changes in the environment is an important function of the nervous system. A universal problem for motile animals is the discovery that a learned route is blocked and a detour is required. Given the substantial neuroscience research on spatial navigation and decision-making it is surprising that so little is known about how the brain solves the detour problem. Here we review the limited number of relevant functional neuroimaging, single unit recording and lesion studies. We find that while the prefrontal cortex (PFC) consistently responds to detours, the hippocampus does not. Recent evidence suggests the hippocampus tracks information about the future path distance to the goal. Based on this evidence we postulate a conceptual model in which: Lateral PFC provides a prediction error signal about the change in the path, frontopolar and superior PFC support the re-formulation of the route plan as a novel subgoal and the hippocampus simulates the new path. More data will be required to validate this model and understand (1) how the system processes the different options; and (2) deals with situations where a new path becomes available (i.e., shortcuts).

Effective Practices for Training and Inspiring High School Physics Teachers

NASA Astrophysics Data System (ADS)

Magee-Sauer, Karen

It is well-documented that there is a nationwide shortage of highly qualified high school physics teachers. Not surprising, institutions of higher education report that the most common number of physics teacher graduates is zero with the majority of institutions graduating less than two physics teachers per year. With these statistics in mind, it is critical that institutions take a careful look at how they recruit, train, and contribute to the retention of high school physics teachers. PhysTEC is a partnership between the APS and AAPT that is dedicated to improving and promoting the education of high school physics teachers. Primarily funded by the NSF and its partnering organizations, PhysTEC has identified key components that are common to successful physics teacher preparation programs. While creating a successful training program in physics, it is also important that students have the opportunity for a ``do-able'' path to certification that does not add further financial debt. This talk will present an overview of ``what works'' in creating a path for physics majors to a high school physics teaching career, actions and activities that help train and inspire pre-service physics teachers, and frameworks that provide the support for in-service teachers. Obstacles to certification and the importance of a strong partnership with colleges of education will be discussed. Several examples of successful physics high school teacher preparation programs will be presented. This material is part of the Physics Teacher Education Coalition project, which is based upon work supported by the National Science Foundation under Grant Nos. 0808790, 0108787, and 0833210.

a Framework for AN Open Source Geospatial Certification Model

NASA Astrophysics Data System (ADS)

Khan, T. U. R.; Davis, P.; Behr, F.-J.

2016-06-01

The geospatial industry is forecasted to have an enormous growth in the forthcoming years and an extended need for well-educated workforce. Hence ongoing education and training play an important role in the professional life. Parallel, in the geospatial and IT arena as well in the political discussion and legislation Open Source solutions, open data proliferation, and the use of open standards have an increasing significance. Based on the Memorandum of Understanding between International Cartographic Association, OSGeo Foundation, and ISPRS this development led to the implementation of the ICA-OSGeo-Lab imitative with its mission "Making geospatial education and opportunities accessible to all". Discussions in this initiative and the growth and maturity of geospatial Open Source software initiated the idea to develop a framework for a worldwide applicable Open Source certification approach. Generic and geospatial certification approaches are already offered by numerous organisations, i.e., GIS Certification Institute, GeoAcademy, ASPRS, and software vendors, i. e., Esri, Oracle, and RedHat. They focus different fields of expertise and have different levels and ways of examination which are offered for a wide range of fees. The development of the certification framework presented here is based on the analysis of diverse bodies of knowledge concepts, i.e., NCGIA Core Curriculum, URISA Body Of Knowledge, USGIF Essential Body Of Knowledge, the "Geographic Information: Need to Know", currently under development, and the Geospatial Technology Competency Model (GTCM). The latter provides a US American oriented list of the knowledge, skills, and abilities required of workers in the geospatial technology industry and influenced essentially the framework of certification. In addition to the theoretical analysis of existing resources the geospatial community was integrated twofold. An online survey about the relevance of Open Source was performed and evaluated with 105 respondents worldwide. 15 interviews (face-to-face or by telephone) with experts in different countries provided additional insights into Open Source usage and certification. The findings led to the development of a certification framework of three main categories with in total eleven sub-categories, i.e., "Certified Open Source Geospatial Data Associate / Professional", "Certified Open Source Geospatial Analyst Remote Sensing & GIS", "Certified Open Source Geospatial Cartographer", "Certified Open Source Geospatial Expert", "Certified Open Source Geospatial Associate Developer / Professional Developer", "Certified Open Source Geospatial Architect". Each certification is described by pre-conditions, scope and objectives, course content, recommended software packages, target group, expected benefits, and the methods of examination. Examinations can be flanked by proofs of professional career paths and achievements which need a peer qualification evaluation. After a couple of years a recertification is required. The concept seeks the accreditation by the OSGeo Foundation (and other bodies) and international support by a group of geospatial scientific institutions to achieve wide and international acceptance for this Open Source geospatial certification model. A business case for Open Source certification and a corresponding SWOT model is examined to support the goals of the Geo-For-All initiative of the ICA-OSGeo pact.

Feedback-Driven Dynamic Invariant Discovery

NASA Technical Reports Server (NTRS)

Zhang, Lingming; Yang, Guowei; Rungta, Neha S.; Person, Suzette; Khurshid, Sarfraz

2014-01-01

Program invariants can help software developers identify program properties that must be preserved as the software evolves, however, formulating correct invariants can be challenging. In this work, we introduce iDiscovery, a technique which leverages symbolic execution to improve the quality of dynamically discovered invariants computed by Daikon. Candidate invariants generated by Daikon are synthesized into assertions and instrumented onto the program. The instrumented code is executed symbolically to generate new test cases that are fed back to Daikon to help further re ne the set of candidate invariants. This feedback loop is executed until a x-point is reached. To mitigate the cost of symbolic execution, we present optimizations to prune the symbolic state space and to reduce the complexity of the generated path conditions. We also leverage recent advances in constraint solution reuse techniques to avoid computing results for the same constraints across iterations. Experimental results show that iDiscovery converges to a set of higher quality invariants compared to the initial set of candidate invariants in a small number of iterations.

FameLab provides competition and coaching on science communication

NASA Astrophysics Data System (ADS)

Scalice, Daniella; Weiss, Peter

2012-10-01

In today's media-intensive environment, the ability to convey science can reshape the face of scientific exploration and discovery. Many early-career scientists could benefit from training on how to communicate their work effectively to all stakeholders along their career paths, from deans and political representatives to neighbors and students, and perhaps even to public audiences through the lens of a camera or the voice of a blog.

Comparing the Impact of Course-Based and Apprentice-Based Research Experiences in a Life Science Laboratory Curriculum†

PubMed Central

Shapiro, Casey; Moberg-Parker, Jordan; Toma, Shannon; Ayon, Carlos; Zimmerman, Hilary; Roth-Johnson, Elizabeth A.; Hancock, Stephen P.; Levis-Fitzgerald, Marc; Sanders, Erin R.

2015-01-01

This four-year study describes the assessment of a bifurcated laboratory curriculum designed to provide upper-division undergraduate majors in two life science departments meaningful exposure to authentic research. The timing is critical as it provides a pathway for both directly admitted and transfer students to enter research. To fulfill their degree requirements, all majors complete one of two paths in the laboratory program. One path immerses students in scientific discovery experienced through team research projects (course-based undergraduate research experiences, or CUREs) and the other path through a mentored, independent research project (apprentice-based research experiences, or AREs). The bifurcated laboratory curriculum was structured using backwards design to help all students, irrespective of path, achieve specific learning outcomes. Over 1,000 undergraduates enrolled in the curriculum. Self-report survey results indicate that there were no significant differences in affective gains by path. Students conveyed which aspects of the curriculum were critical to their learning and development of research-oriented skills. Students’ interests in biology increased upon completion of the curriculum, inspiring a subset of CURE participants to subsequently pursue further research. A rubric-guided performance evaluation, employed to directly measure learning, revealed differences in learning gains for CURE versus ARE participants, with evidence suggesting a CURE can reduce the achievement gap between high-performing students and their peers. PMID:26751568

Toward Omics-Based, Systems Biomedicine, and Path and Drug Discovery Methodologies for Depression-Inflammation Research.

PubMed

Maes, Michael; Nowak, Gabriel; Caso, Javier R; Leza, Juan Carlos; Song, Cai; Kubera, Marta; Klein, Hans; Galecki, Piotr; Noto, Cristiano; Glaab, Enrico; Balling, Rudi; Berk, Michael

2016-07-01

Meta-analyses confirm that depression is accompanied by signs of inflammation including increased levels of acute phase proteins, e.g., C-reactive protein, and pro-inflammatory cytokines, e.g., interleukin-6. Supporting the translational significance of this, a meta-analysis showed that anti-inflammatory drugs may have antidepressant effects. Here, we argue that inflammation and depression research needs to get onto a new track. Firstly, the choice of inflammatory biomarkers in depression research was often too selective and did not consider the broader pathways. Secondly, although mild inflammatory responses are present in depression, other immune-related pathways cannot be disregarded as new drug targets, e.g., activation of cell-mediated immunity, oxidative and nitrosative stress (O&NS) pathways, autoimmune responses, bacterial translocation, and activation of the toll-like receptor and neuroprogressive pathways. Thirdly, anti-inflammatory treatments are sometimes used without full understanding of their effects on the broader pathways underpinning depression. Since many of the activated immune-inflammatory pathways in depression actually confer protection against an overzealous inflammatory response, targeting these pathways may result in unpredictable and unwanted results. Furthermore, this paper discusses the required improvements in research strategy, i.e., path and drug discovery processes, omics-based techniques, and systems biomedicine methodologies. Firstly, novel methods should be employed to examine the intracellular networks that control and modulate the immune, O&NS and neuroprogressive pathways using omics-based assays, including genomics, transcriptomics, proteomics, metabolomics, epigenomics, immunoproteomics and metagenomics. Secondly, systems biomedicine analyses are essential to unravel the complex interactions between these cellular networks, pathways, and the multifactorial trigger factors and to delineate new drug targets in the cellular networks or pathways. Drug discovery processes should delineate new drugs targeting the intracellular networks and immune-related pathways.

High Contrast Astronomy with Starshades

NASA Astrophysics Data System (ADS)

Harness, Anthony D.

2016-09-01

One of the most important scientific discoveries to be had this century is the spectroscopic characterization of Earth-like exoplanets to determine the occurrence rate of worlds capable of supporting life and to potentially answer: are we alone in the universe? To accomplish these lofty goals requires an advancement in the technology to separate the overwhelming starlight from that of the exoplanet. I believe starshades are the key technology that will enable these discoveries within our lifetime. This dissertation work is a contribution to the advancement of starshade technology to put us on the path towards discovery. In this dissertation I present a number of suborbital methods developed for testing small-scale starshades, which include a Vertical Takeoff Vertical Landing rocket, the surface of a dry lake bed, and the heliostat of a solar telescope. The results from our high contrast observations are used to validate the optical model I developed to conduct tolerance analyses that will drive future starshade designs. The results from testing a formation flying sensor on the VTVL rocket demonstrate the rocket's potential for conducting starshade experiments in the stratosphere. This dissertation (along with [Novicki, et al. (2016)]) presents the first astronomical observations with a starshade that provide photometric measurements of stars, previously unobserved in the visible spectrum, in the proximity of Vega. These observations led to the development of a visual feedback system for the heliostat that allows us to push farther in separation and inner working angle. These high contrast observations were made using a starshade in the most flight-like configuration (in terms of Fresnel number, inner working angle, and resolution) to date. The results of this dissertation have helped demonstrate the effectiveness and practicality of starshades for starlight suppression and have outlined a path forward to further advance starshade technology through optical testing and high contrast astronomy.

Ninth Triennial Toxicology Salary Survey.

PubMed

Gad, Shayne Cox; Sullivan, Dexter Wayne

2016-01-01

This survey serves as the ninth in a series of toxicology salary surveys conducted at 3-year intervals and beginning in 1988. An electronic survey instrument was distributed to 5919 individuals including members of the Society of Toxicology, American College of Toxicology, and 23 additional professional organizations. Question items inquired about gender, age, degree, years of experience, certifications held, areas of specialization, society membership, employment and income. Overall, 1293 responses were received (response rate 21.8%). The results of the 2014 survey provide insight into the job market and career path for current and future toxicologists. © The Author(s) 2016.

[Quality system in cardiology: practical example to develop an organizational model for management certification without bureaucracy].

PubMed

Colonna, Paolo; Pasini, Evasio; Pitocchi, Oreste; Bovenzi, Francesco; Sorino, Margherita; de Luca, Italo

2003-04-01

It is a difficult task to define practical guidelines and a pragmatic achievement for the new document of the Italian Ministry of Health for structures of the national health system obtaining a quality system according to the ISO 9000 standard. The present article illustrates the different steps to accomplish the quality management in our cardiology department, recently internationally certified, and it gives several practical examples of the path followed in the different sections of the department to obtain the best management of all the Operative Units, identifying customer requests and measuring customer satisfaction.

Control of Space-Based Electron Beam Free Form Fabrication

NASA Technical Reports Server (NTRS)

Seifzer. W. J.; Taminger, K. M.

2007-01-01

Engineering a closed-loop control system for an electron beam welder for space-based additive manufacturing is challenging. For earth and space based applications, components must work in a vacuum and optical components become occluded with metal vapor deposition. For extraterrestrial applications added components increase launch weight, increase complexity, and increase space flight certification efforts. Here we present a software tool that closely couples path planning and E-beam parameter controls into the build process to increase flexibility. In an environment where data collection hinders real-time control, another approach is considered that will still yield a high quality build.

Evaluation of the U.S. Department of Energy Challenge Home Program Certification of Production Builders

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kerrigan, P.; Loomis, H.

2014-09-01

The purpose of this project was to evaluate integrated packages of advanced measures in individual test homes to assess their performance with respect to Building America program goals, specifically compliance with the DOE Challenge Home Program. BSC consulted on the construction of five test houses by three cold climate production builders in three U.S. cities and worked with the builders to develop a design package tailored to the cost-related impacts for each builder. Also, BSC provided support through performance testing of the five test homes. Overall, the builders have concluded that the energy related upgrades (either through the prescriptive ormore » performance path) represent reasonable upgrades. The builders commented that while not every improvement in specification was cost effective (as in a reasonable payback period), many were improvements that could improve the marketability of the homes and serve to attract more energy efficiency discerning prospective homeowners. However, the builders did express reservations on the associated checklists and added certifications. An increase in administrative time was observed with all builders. The checklists and certifications also inherently increase cost due to: adding services to the scope of work for various trades, such as HERS Rater, HVAC contractor; and increased material costs related to the checklists, especially the EPA Indoor airPLUS and EPA WaterSense® Efficient Hot Water Distribution requirement.« less

Graph Analytics for Signature Discovery

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hogan, Emilie A.; Johnson, John R.; Halappanavar, Mahantesh

2013-06-01

Within large amounts of seemingly unstructured data it can be diffcult to find signatures of events. In our work we transform unstructured data into a graph representation. By doing this we expose underlying structure in the data and can take advantage of existing graph analytics capabilities, as well as develop new capabilities. Currently we focus on applications in cybersecurity and communication domains. Within cybersecurity we aim to find signatures for perpetrators using the pass-the-hash attack, and in communications we look for emails or phone calls going up or down a chain of command. In both of these areas, and inmore » many others, the signature we look for is a path with certain temporal properties. In this paper we discuss our methodology for finding these temporal paths within large graphs.« less

Visual images in Luigi Galvani's path to animal electricity.

PubMed

Piccolino, Marco

2008-01-01

The scientific endeavor that led Luigi Galvani to his hypothesis of "animal electricity," i.e., of an electricity present in a condition of disequilibrium between the interior and the exterior of excitable animal fibers, is reviewed here with particular emphasis to the role played by visual images in Galvani's path of discovery. In 1791 Galvani formulated his model of neuromuscular physiology on the base of the image of a muscle and a nerve fiber together as in a "minute animal Leyden jar." This was the last instance of a series of physical models that accompanied Galvani's experimental efforts in the search of a theory capable of accounting for the electric nature of nerve conduction in spite of the many objections formulated in the eighteenth century against a possible role of electricity in animal physiology.

The Path to Interferometry in Space

NASA Technical Reports Server (NTRS)

Rinehart, S. A.; Savini, G.; Holland, W.; Absil, O.; Defrere, D.; Spencer, L.; Leisawitz, D.; Rizzo, M.; Juanola-Parramon, R.; Mozurkewich, D.

2016-01-01

For over two decades, astronomers have considered the possibilities for interferometry in space. The first of these missions was the Space Interferometry Mission (SIM), but that was followed by missions for studying exoplanets (e.g Terrestrial Planet Finder, Darwin), and then far-infrared interferometers (e.g. the Space Infrared Interferometric Telescope, the Far-Infrared Interferometer). Unfortunately, following the cancellation of SIM, the future for space-based interferometry has been in doubt, and the interferometric community needs to reevaluate the path forward. While interferometers have strong potential for scientific discovery, there are technological developments still needed, and continued maturation of techniques is important for advocacy to the broader astronomical community. We review the status of several concepts for space-based interferometry, and look for possible synergies between missions oriented towards different science goals.

The path forward: 2015 International Children's Tumor Foundation conference on neurofibromatosis type 1, type 2, and schwannomatosis.

PubMed

Blakeley, Jaishri O; Bakker, Annette; Barker, Anne; Clapp, Wade; Ferner, Rosalie; Fisher, Michael J; Giovannini, Marco; Gutmann, David H; Karajannis, Matthias A; Kissil, Joseph L; Legius, Eric; Lloyd, Alison C; Packer, Roger J; Ramesh, Vijaya; Riccardi, Vincent M; Stevenson, David A; Ullrich, Nicole J; Upadhyaya, Meena; Stemmer-Rachamimov, Anat

2017-06-01

The Annual Children's Tumor Foundation International Neurofibromatosis Meeting is the premier venue for connecting discovery, translational and clinical scientists who are focused on neurofibromatosis types 1 and 2 (NF1 and NF2) and schwannomatosis (SWN). The meeting also features rare tumors such as glioma, meningioma, sarcoma, and neuroblastoma that occur both within these syndromes and spontaneously; associated with somatic mutations in NF1, NF2, and SWN. The meeting addresses both state of the field for current clinical care as well as emerging preclinical models fueling discovery of new therapeutic targets and discovery science initiatives investigating mechanisms of tumorigenesis. Importantly, this conference is a forum for presenting work in progress and bringing together all stakeholders in the scientific community. A highlight of the conference was the involvement of scientists from the pharmaceutical industry who presented growing efforts for rare disease therapeutic development in general and specifically, in pediatric patients with rare tumor syndromes. Another highlight was the focus on new investigators who presented new data about biomarker discovery, tumor pathogenesis, and diagnostic tools for NF1, NF2, and SWN. This report summarizes the themes of the meeting and a synthesis of the scientific discoveries presented at the conference in order to make the larger research community aware of progress in the neurofibromatoses. © 2017 Wiley Periodicals, Inc.

Credentialing Data Scientists: A Domain Repository Perspective

NASA Astrophysics Data System (ADS)

Lehnert, K. A.; Furukawa, H.

2015-12-01

A career in data science can have many paths: data curation, data analysis, metadata modeling - all of these in different commercial or scientific applications. Can a certification as 'data scientist' provide the guarantee that an applicant or candidate for a data science position has just the right skills? How valuable is a 'generic' certification as data scientist for an employer looking to fill a data science position? Credentials that are more specific and discipline-oriented may be more valuable to both the employer and the job candidate. One employment sector for data scientists are the data repositories that provide discipline-specific data services for science communities. Data science positions within domain repositories include a wide range of responsibilities in support of the full data life cycle - from data preservation and curation to development of data models, ontologies, and user interfaces, to development of data analysis and visualization tools to community education and outreach, and require a substantial degree of discipline-specific knowledge of scientific data acquisition and analysis workflows, data quality measures, and data cultures. Can there be certification programs for domain-specific data scientists that help build the urgently needed workforce for the repositories? The American Geophysical Union has recently started an initiative to develop a program for data science continuing education and data science professional certification for the Earth and space sciences. An Editorial Board has been charged to identify and develop curricula and content for these programs and to provide input and feedback in the implementation of the program. This presentation will report on the progress of this initiative and evaluate its utility for the needs of domain repositories in the Earth and space sciences.

Future hadron colliders: From physics perspectives to technology R&D

NASA Astrophysics Data System (ADS)

Barletta, William; Battaglia, Marco; Klute, Markus; Mangano, Michelangelo; Prestemon, Soren; Rossi, Lucio; Skands, Peter

2014-11-01

High energy hadron colliders have been instrumental to discoveries in particle physics at the energy frontier and their role as discovery machines will remain unchallenged for the foreseeable future. The full exploitation of the LHC is now the highest priority of the energy frontier collider program. This includes the high luminosity LHC project which is made possible by a successful technology-readiness program for Nb3Sn superconductor and magnet engineering based on long-term high-field magnet R&D programs. These programs open the path towards collisions with luminosity of 5×1034 cm-2 s-1 and represents the foundation to consider future proton colliders of higher energies. This paper discusses physics requirements, experimental conditions, technological aspects and design challenges for the development towards proton colliders of increasing energy and luminosity.

Multitarget drug discovery projects in CNS diseases: quantitative systems pharmacology as a possible path forward.

PubMed

Geerts, Hugo; Kennis, Ludo

2014-01-01

Clinical development in brain diseases has one of the lowest success rates in the pharmaceutical industry, and many promising rationally designed single-target R&D projects fail in expensive Phase III trials. By contrast, successful older CNS drugs do have a rich pharmacology. This article will provide arguments suggesting that highly selective single-target drugs are not sufficiently powerful to restore complex neuronal circuit homeostasis. A rationally designed multitarget project can be derisked by dialing in an additional symptomatic treatment effect on top of a disease modification target. Alternatively, we expand upon a hypothetical workflow example using a humanized computer-based quantitative systems pharmacology platform. The hope is that incorporating rationally multipharmacology drug discovery could potentially lead to more impactful polypharmacy drugs.

VERITAS: a Discovery-Class Venus Surface Geology and Geophysics Mission

NASA Technical Reports Server (NTRS)

Freeman, Anthony; Smrekar, Suzanne E.; Hensley, Scott; Wallace, Mark; Sotin, Christophe; Darrach, Murray; Xaypraseuth, Peter; Helbert, Joern; Mazarico, Erwan

2016-01-01

Our understanding of solar system evolution is limited by a great unanswered question: How Earthlike is Venus? We know that these "twin" planets formed with similar bulk composition and size. Yet the evolutionary path Venus followed has diverged from Earth's, in losing its surface water and becoming hotter than Mercury. What led to this? The answer has profound implications for how terrestrial planets become habitable and the potential for life in the universe.

Middleware Solutions for Self-organizing Multi-hop Multi-path Internet Connectivity Based on Bluetooth

NASA Astrophysics Data System (ADS)

Bellavista, Paolo; Giannelli, Carlo

The availability of heterogeneous wireless interfaces and of growing computing resources on widespread portable devices pushes for enabling innovative deployment scenarios where mobile nodes dynamically self-organize to offer Internet connectivity to their peers via dynamically established multi-hop multi-path opportunities. We claim the suitability of novel, mobility-aware, and application-layer middleware based on lightweight evaluation indicators to support the complexity of that scenario, involving heterogeneous wireless technologies over differentiated and statically unpredictable execution environments. To validate these claims, we have implemented an innovative middleware that manages the durability/throughput-aware formation and selection of different multi-hop paths simultaneously. This paper specifically focuses on how our middleware effectively exploits Bluetooth for multi-hop multi-path networking, by pointing out the crucial role of i) compliance with standard solutions to favor rapid deployment over off-the-shelf equipment and ii) the reduction of the usual overhead associated with some expensive Bluetooth operations, e.g., device inquiry. In particular, the paper shows how it is possible, on the one hand, to extend JSR-82 to portably access monitoring indicators for lightweight mobility/throughput estimations and, on the other hand, to reduce the time needed to update the set of available Bluetooth-based connectivity opportunities via approximated and lightweight forms of discovery.

Tracking the Career Paths of Physics Teachers in Texas

NASA Astrophysics Data System (ADS)

Mount, Jennifer; Marshall, Jill; Fuller, Edward

2013-10-01

In Texas, and some other states, there is a documented shortage of physics teachers, in terms of both number and qualifications. The shortage in Texas is due as much to teachers leaving the field (attrition) as to a lack of teachers entering. There are efforts under way to prepare more and better-qualified physics teachers who will stay in the field longer,2 but increasing the overall supply and retention will not necessarily address localized teacher shortages. To investigate this issue, we obtained a database cataloging every teacher who taught science in Texas public schools from 2003 to 2008, indicating the school where they taught during each of those years, the subjects they taught, and their route to certification. This allowed us to track not only teachers entering and leaving the public school system, but also migration between schools within the system. We found that migration poses a much bigger problem than attrition for some schools. We also found patterns in the movement of physics teachers in Texas that we would not necessarily have predicted and that varied substantially depending on certification.

National Training and Education Standards for Health and Wellness Coaching: The Path to National Certification

PubMed Central

Wolever, Ruth Q.; Lawson, Karen; Moore, Margaret

2015-01-01

The purpose of this article is twofold: (1) to announce the findings of the job task analysis as well as national training and education standards for health and wellness coaching (HWC) that have been developed by the large-scale, collaborative efforts of the National Consortium for Credentialing Health and Wellness Coaches (NCCHWC) and (2) to invite commentary from the public. The rapid proliferation of individuals and organizations using the terms of health and/or wellness coaches and the propagation of private industry and academic coach training and education programs endeavoring to prepare these coaches has created an urgent and pressing need for national standards for use of the term health and wellness coach, as well as minimal requirements for training, education, and certification. Professionalizing the field with national standards brings a clear and consistent definition of health and wellness coaching and accepted practice standards that are uniform across the field. In addition, clear standards allow for uniform curricular criteria to ensure a minimal benchmark for education, training, and skills and knowledge evaluation of professional health and wellness coaches. PMID:25984418

Report on the 10th anniversary of international drug discovery science and technology conference, 8 - 10 november 2012, nanjing, china.

PubMed

Everett, Jeremy R

2013-03-01

The 10th Anniversary of International Drug Discovery Science and Technology (IDDST) Conference was held in Nanjing, China from 8 to 10 November 2012. The conference ran in parallel with the 2nd Annual Symposium of Drug Delivery Systems. Over 400 delegates from both conferences came together for the Opening Ceremony and Keynote Addresses but otherwise pursued separate paths in the huge facilities of the Nanjing International Expo Centre. The IDDST was arranged into 19 separate Chapters covering drug discovery biology, target validation, chemistry, rational drug design, pharmacology and toxicology, drug screening technology, 'omics' technologies, analytical, automation and enabling technologies, informatics, stem cells and regenerative medicine, bioprocessing, generics, biosimilars and biologicals and seven disease areas: cancer, CNS, respiratory and inflammation, autoimmune, emerging infectious, bone and orphan diseases. There were also two sessions of a 'Bench to Bedside to Business' Program and a Chinese Scientist programme. In each period of the IDDST conference, up to seven sessions were running in parallel. This Meeting Highlight samples just a fraction of the content of this large meeting. The talks included have as a link, the use of new approaches to drug discovery. Many other excellent talks could have been highlighted and the author has necessarily had to be selective.

The Discovery of the Tau Lepton: Part 1, The Early History Through 1975; Part 2, Confirmation of the Discovery and Measurement of Major Properties, 1976--1982

DOE R&D Accomplishments Database

Perl, M. L.

1994-08-01

Several previous papers have given the history of the discovery of the {tau} lepton at the Stanford Linear Accelerator Center (SLAC). These papers emphasized (a) the experiments which led to our 1975 publication of the first evidence for the existence of the {tau}, (b) the subsequent experiments which confirmed the existence of the r, and (c) the experiments which elucidated the major properties of the {tau}. That history will be summarized in Part 2 of this talk. In this Part 1, I describe the earlier thoughts and work of myself and my colleagues at SLAC in the 1960's and early 1970's which led to the discovery. I also describe the theoretical and experimental events in particle physics in the 1960's in which our work was immersed. I will also try to describe for the younger generations of particle physicists, the atmosphere in the 1960's. That was before the elucidation of the quark model of hadrons, before the development of the concept of particle generations The experimental paths to program we hot as clear as they are today and we had to cast a wide experimental net.

The Mathematics of Mixing Things Up

NASA Astrophysics Data System (ADS)

Diaconis, Persi

2011-08-01

How long should a Markov chain Monte Carlo algorithm be run? Using examples from statistical physics (Ehrenfest urn, Ising model, hard discs) as well as card shuffling, this tutorial paper gives an overview of a body of mathematical results that can give useful answers to practitioners (viz: seven shuffles suffice for practical purposes). It points to new techniques (path coupling, geometric inequalities, and Harris recurrence). The discovery of phase transitions in mixing times (the cutoff phenomenon) is emphasized.

Ka-Band Propagation Studies using the ACTS Propagation Terminal and the CSU-CHILL Multiparameter Radar

NASA Technical Reports Server (NTRS)

Bringi, V. N.; Beaver, John

1996-01-01

One of the first experimental communications satellites using Ka-band technology is the NASA Advanced Communications Technology Satellite (ACTS). In September 1993, ACTS was deployed into a geostationary orbit near 100 degrees W longitude by the space shuttle Discovery. The ACTS system supports both communication and propagation experiments at the 20/30 GHz frequency bands. The propagation experiment involves multi-year attenuation measurements along the satellite-Earth slant path.

Why our patients (and we) need basic science research.

PubMed

Schor, Nina F

2013-05-28

In times of fiscal austerity, the tendency is to seek instant, inexpensive gratification. In the case of biomedical research, this means the shortest path to practical clinical implementation. But fueling the translational pipeline with discovery depends critically on allowing the biomedical research community to follow their science where it takes them. Fiscal constraints carry with them the risk of squelching creativity and forfeiting the power of serendipity to provide the substrate for the translational engine in the future.

Bridging the gap to therapeutic strategies based on connexin/pannexin biology.

PubMed

Naus, Christian C; Giaume, Christian

2016-11-29

A unique workshop was recently held focusing on enhancing collaborations leading to identify and update the development of therapeutic strategies targeting connexin/pannexin large pore channels. Basic scientists exploring the functions of these channels in various pathologies gathered together with leading pharma companies which are targeting gap junction proteins for specific therapeutic applications. This highlights how paths of discovery research can converge with therapeutic strategies in innovative ways to enhance target identification and validation.

Exp 29 9-13-10 crew approved

NASA Image and Video Library

2010-09-13

ISS029-S-001 (23 March 2011) --- On the Expedition 29 patch, the International Space Station (ISS) is shown following the path of the historic 18th century explorer, Captain James Cook, and his ship, Endeavour. During Cook?s three main voyages, he explored and mapped major portions of the oceans and coastlines under the flight path of the ISS and added immeasurably to the body of knowledge of that time. As the ISS sails a stardust trail ? following the spirit of Endeavour sailing toward the dark unknown and new discoveries ? it enlightens Earth below. Through the centuries, the quest for new discoveries has been a significant element of the human character, inspiring us to endure hardships and separation to be part of a mission which is greater than any individual. A spokesman for the crew stated, ?The crew of Expedition 29 is proud to continue the journey in this greatest of all human endeavors.? The NASA insignia design for shuttle and space station flights is reserved for use by the astronauts and for other official use as the NASA Administrator may authorize. Public availability has been approved only in the form of illustrations by the various news media. When and if there is any change in this policy, which is not anticipated, it will be publicly announced. Photo credit: NASA or National Aeronautics and Space Administration

DOE Office of Scientific and Technical Information (OSTI.GOV)

,

The reports included in this report are for project activities that occurred from October 2011 through September 2012. These reports describe in detail the discoveries, achievements, and challenges encountered by our talented and enthusiastic principal investigators (PIs). Many of the reports describe R&D efforts that were “successful” in their pursuits and resulted in a positive outcome or technology realization. As we’ve stated before, and continue to stress, in some cases the result is a “negative” finding, for instance a technology is currently impractical or out of reach. This can often be viewed erroneously as a “failure,” but is actually amore » valid outcome in the pursuit of high-risk research, which often leads to unforeseen new paths of discovery. Either result advances our knowledge and increases our ability to identify solutions and/or likewise avoid costly paths not appropriate for the challenges presented. The SDRD program continues to provide an unfettered mechanism for innovation and development that returns multifold to the NNSS mission. Overall the program is a strong R&D innovation engine, benefited by an enhanced mission, committed resources, and sound competitiveness to yield maximum benefit. The 23 projects described exemplify the creativity and ability of a diverse scientific and engineering talent base. The efforts also showcase an impressive capability and resource that can be brought to find solutions to a broad array of technology needs and applications relevant to the NNSS mission and national security.« less

k-neighborhood Decentralization: A Comprehensive Solution to Index the UMLS for Large Scale Knowledge Discovery

PubMed Central

Xiang, Yang; Lu, Kewei; James, Stephen L.; Borlawsky, Tara B.; Huang, Kun; Payne, Philip R.O.

2011-01-01

The Unified Medical Language System (UMLS) is the largest thesaurus in the biomedical informatics domain. Previous works have shown that knowledge constructs comprised of transitively-associated UMLS concepts are effective for discovering potentially novel biomedical hypotheses. However, the extremely large size of the UMLS becomes a major challenge for these applications. To address this problem, we designed a k-neighborhood Decentralization Labeling Scheme (kDLS) for the UMLS, and the corresponding method to effectively evaluate the kDLS indexing results. kDLS provides a comprehensive solution for indexing the UMLS for very efficient large scale knowledge discovery. We demonstrated that it is highly effective to use kDLS paths to prioritize disease-gene relations across the whole genome, with extremely high fold-enrichment values. To our knowledge, this is the first indexing scheme capable of supporting efficient large scale knowledge discovery on the UMLS as a whole. Our expectation is that kDLS will become a vital engine for retrieving information and generating hypotheses from the UMLS for future medical informatics applications. PMID:22154838

Data discovery with DATS: exemplar adoptions and lessons learned.

PubMed

Gonzalez-Beltran, Alejandra N; Campbell, John; Dunn, Patrick; Guijarro, Diana; Ionescu, Sanda; Kim, Hyeoneui; Lyle, Jared; Wiser, Jeffrey; Sansone, Susanna-Assunta; Rocca-Serra, Philippe

2018-01-01

The DAta Tag Suite (DATS) is a model supporting dataset description, indexing, and discovery. It is available as an annotated serialization with schema.org, a vocabulary used by major search engines, thus making the datasets discoverable on the web. DATS underlies DataMed, the National Institutes of Health Big Data to Knowledge Data Discovery Index prototype, which aims to provide a "PubMed for datasets." The experience gained while indexing a heterogeneous range of >60 repositories in DataMed helped in evaluating DATS's entities, attributes, and scope. In this work, 3 additional exemplary and diverse data sources were mapped to DATS by their representatives or experts, offering a deep scan of DATS fitness against a new set of existing data. The procedure, including feedback from users and implementers, resulted in DATS implementation guidelines and best practices, and identification of a path for evolving and optimizing the model. Finally, the work exposed additional needs when defining datasets for indexing, especially in the context of clinical and observational information. © The Author 2017. Published by Oxford University Press on behalf of the American Medical Informatics Association.

k-Neighborhood decentralization: a comprehensive solution to index the UMLS for large scale knowledge discovery.

PubMed

Xiang, Yang; Lu, Kewei; James, Stephen L; Borlawsky, Tara B; Huang, Kun; Payne, Philip R O

2012-04-01

The Unified Medical Language System (UMLS) is the largest thesaurus in the biomedical informatics domain. Previous works have shown that knowledge constructs comprised of transitively-associated UMLS concepts are effective for discovering potentially novel biomedical hypotheses. However, the extremely large size of the UMLS becomes a major challenge for these applications. To address this problem, we designed a k-neighborhood Decentralization Labeling Scheme (kDLS) for the UMLS, and the corresponding method to effectively evaluate the kDLS indexing results. kDLS provides a comprehensive solution for indexing the UMLS for very efficient large scale knowledge discovery. We demonstrated that it is highly effective to use kDLS paths to prioritize disease-gene relations across the whole genome, with extremely high fold-enrichment values. To our knowledge, this is the first indexing scheme capable of supporting efficient large scale knowledge discovery on the UMLS as a whole. Our expectation is that kDLS will become a vital engine for retrieving information and generating hypotheses from the UMLS for future medical informatics applications. Copyright © 2011 Elsevier Inc. All rights reserved.

Blood-based biomarkers in Alzheimer disease: Current state of the science and a novel collaborative paradigm for advancing from discovery to clinic.

PubMed

O'Bryant, Sid E; Mielke, Michelle M; Rissman, Robert A; Lista, Simone; Vanderstichele, Hugo; Zetterberg, Henrik; Lewczuk, Piotr; Posner, Holly; Hall, James; Johnson, Leigh; Fong, Yiu-Lian; Luthman, Johan; Jeromin, Andreas; Batrla-Utermann, Richard; Villarreal, Alcibiades; Britton, Gabrielle; Snyder, Peter J; Henriksen, Kim; Grammas, Paula; Gupta, Veer; Martins, Ralph; Hampel, Harald

2017-01-01

The last decade has seen a substantial increase in research focused on the identification of blood-based biomarkers that have utility in Alzheimer's disease (AD). Blood-based biomarkers have significant advantages of being time- and cost-efficient as well as reduced invasiveness and increased patient acceptance. Despite these advantages and increased research efforts, the field has been hampered by lack of reproducibility and an unclear path for moving basic discovery toward clinical utilization. Here we reviewed the recent literature on blood-based biomarkers in AD to provide a current state of the art. In addition, a collaborative model is proposed that leverages academic and industry strengths to facilitate the field in moving past discovery only work and toward clinical use. Key resources are provided. This new public-private partnership model is intended to circumvent the traditional handoff model and provide a clear and useful paradigm for the advancement of biomarker science in AD and other neurodegenerative diseases. Copyright © 2016 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved.

Blood Based Biomarkers in Alzheimer Disease: Current State of the Science and a Novel Collaborative Paradigm for Advancing from Discovery to Clinic

PubMed Central

O’Bryant, Sid E.; Mielke, Michelle M.; Rissman, Robert A.; Lista, Simone; Vanderstichele, Hugo; Zetterberg, Henrik; Lewczuk, Piotr; Posner, Holly; Hall, James; Johnson, Leigh; Fong, Yiu-Lian; Luthman, Johan; Jeromin, Andreas; Batrla-Utermann, Richard; Villarreal, Alcibiades; Britton, Gabrielle; Snyder, Peter J.; Henriksen, Kim; Grammas, Paula; Gupta, Veer; Martins, Ralph; Hampel, Harald

2016-01-01

The last decade has seen a substantial increase in research focused on the identification of blood-based biomarkers that have utility in Alzheimer’s disease (AD). Blood-based biomarkers have significant advantages of being time- and cost-efficient as well as reduced invasiveness and increased patient acceptance. Despite these advantages and increased research efforts, the field has been hampered by lack of reproducibility as well as an unclear path for moving basic discovery towards clinical utilization. Here we reviewed the recent literature on blood-based biomarkers in AD to provide a current state-of-the-art. Additionally, a collaborative model is proposed that leverages academic and industry strengths to facilitate the field in moving past discovery only work and towards clinical use. Key resources are provided. This new public-private partnership model is intended to circumvent the traditional hand-off model and provide a clear and useful paradigm for the advancement of biomarker science in AD and other neurodegenerative diseases. PMID:27870940

Silk Film Embossing System

NASA Astrophysics Data System (ADS)

Paquette, Mark S.

New tools are often required to facilitate new discoveries and test new methods. Commercial offerings can be prohibitively expensive and difficult to customize. The development of ad-hoc tools provides the most flexibility and provides an opportunity to modify and refine a technology. An embossing system was developed for silk film imprinting and stamping in order to facilitate and add versatility to the efforts involving micro- and nanoscale device manufacturing in biopolymers. This system features temperature controlled embossing surfaces, adjustable embossing pressures, and variable embossing times. The device can also be fitted with interchangeable temperature controlled embossing and stamping tools. The design, development, fabrication, applications, and future improvements are explored for the system. This device may facilitate new discoveries in the realm of biopolymer micro- and nanomanufacturing and may provide a path towards high volume production of silk film based technologies.

Discovery of CLC transport proteins: cloning, structure, function and pathophysiology

PubMed Central

Jentsch, Thomas J

2015-01-01

Abstract After providing a personal description of the convoluted path leading 25 years ago to the molecular identification of the Torpedo Cl− channel ClC-0 and the discovery of the CLC gene family, I succinctly describe the general structural and functional features of these ion transporters before giving a short overview of mammalian CLCs. These can be categorized into plasma membrane Cl− channels and vesicular Cl−/H+-exchangers. They are involved in the regulation of membrane excitability, transepithelial transport, extracellular ion homeostasis, endocytosis and lysosomal function. Diseases caused by CLC dysfunction include myotonia, neurodegeneration, deafness, blindness, leukodystrophy, male infertility, renal salt loss, kidney stones and osteopetrosis, revealing a surprisingly broad spectrum of biological roles for chloride transport that was unsuspected when I set out to clone the first voltage-gated chloride channel. PMID:25590607

Five critical elements to ensure the precision medicine.

PubMed

Chen, Chengshui; He, Mingyan; Zhu, Yichun; Shi, Lin; Wang, Xiangdong

2015-06-01

The precision medicine as a new emerging area and therapeutic strategy has occurred and was practiced in the individual and brought unexpected successes, and gained high attentions from professional and social aspects as a new path to improve the treatment and prognosis of patients. There will be a number of new components to appear or be discovered, of which clinical bioinformatics integrates clinical phenotypes and informatics with bioinformatics, computational science, mathematics, and systems biology. In addition to those tools, precision medicine calls more accurate and repeatable methodologies for the identification and validation of gene discovery. Precision medicine will bring more new therapeutic strategies, drug discovery and development, and gene-oriented treatment. There is an urgent need to identify and validate disease-specific, mechanism-based, or epigenetics-dependent biomarkers to monitor precision medicine, and develop "precision" regulations to guard the application of precision medicine.

KSC-2012-2337

NASA Image and Video Library

2012-04-16

CAPE CANAVERAL, Fla. – It’s a full house on the tarmac at the Shuttle Landing Facility at NASA’s Kennedy Space Center in Florida with the arrival of astronauts in T-38 jets, the “pathfinder” aircraft for space shuttle Discovery’s ferry flight and the Shuttle Carrier Aircraft with Discovery secured on its back. The astronauts are participating in the festivities related to the final departure of Discovery from Kennedy. The NASA C-9 pathfinder aircraft will fly about 100 miles ahead of Discovery to scout for the safest route between destinations. Its crew includes an SCA flight engineer who studies the weather patterns along the flight path to find a route free of rain and other turbulence. The carrier aircraft, also known as an SCA, is a Boeing 747 jet, originally manufactured for commercial use which was modified by NASA to transport the shuttles between destinations on Earth. NASA 905 is scheduled to ferry Discovery to the Washington Dulles International Airport in Virginia on April 17, and is assigned to all remaining ferry missions, delivering the shuttles to their permanent public display sites. After its arrival at Dulles, Discovery will be placed on display in the Smithsonian's National Air and Space Museum Steven F. Udvar-Hazy Center on April 19. For more information on the SCA, visit http://www.nasa.gov/centers/dryden/news/FactSheets/FS-013-DFRC.html. For more information on shuttle transition and retirement activities, visit http://www.nasa.gov/transition. Photo credit: NASA/Amanda Diller

Changing child neurology training: evolution or revolution?

PubMed

Greenwood, Robert S

2012-02-01

Child neurology training must change as our understanding of the diseases of the developing nervous system increases. A proposed child neurology training path leading to certification in child neurology would eliminate all but 3 months of adult neurology training; however gaining approval for a new Accreditation Council for Graduate Medical Education (ACGME) training program would be an arduous task. I review why this change would add significant administrative and financial burdens and how this change in training could negatively affect the education of child neurology residents. I believe that modifications of the current training requirements already underway could achieve the same aims with fewer losses.

Building America Case Study: Meeting DOE Challenge Home Program Certification, Chicago, Illinois; Denver, Colorado; Devens, Massachusetts (Fact Sheet)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

The purpose of this project was to evaluate integrated packages of advanced measures in individual test homes to assess their performance with respect to Building America Program goals, specifically compliance with the DOE Challenge Home Program. BSC consulted on the construction of five test houses by three Cold Climate production builders in three separate US cities. BSC worked with the builders to develop a design package tailored to the cost-related impacts for each builder. Therefore, the resulting design packages do vary from builder to builder. BSC provided support through this research project on the design, construction and performance testing ofmore » the five test homes. Overall, the builders have concluded that the energy related upgrades (either through the prescriptive or performance path) represent reasonable upgrades. The builders commented that while not every improvement in specification was cost effective (as in a reasonable payback period), many were improvements that could improve the marketability of the homes and serve to attract more energy efficiency discerning prospective homeowners. However, the builders did express reservations on the associated checklists and added certifications. An increase in administrative time was observed with all builders. The checklists and certifications also inherently increase cost due to: 1. Adding services to the scope of work for various trades, such as HERS Rater, HVAC contractor. 2. Increased material costs related to the checklists, especially the EPA Indoor airPLUS and EPA WaterSense Efficient Hot Water Distribution requirement.« less

Evaluation of the U.S. Department of Energy Challenge Home Program Certification of Production Builders

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kerrigan, P.; Loomis, H.

2014-09-01

The purpose of this project was to evaluate integrated packages of advanced measures in individual test homes to assess their performance with respect to Building America Program goals, specifically compliance with the DOE Challenge Home Program. BSC consulted on the construction of five test houses by three Cold Climate production builders in three separate US cities. BSC worked with the builders to develop a design package tailored to the cost-related impacts for each builder. Therefore, the resulting design packages do vary from builder to builder. BSC provided support through this research project on the design, construction and performance testing ofmore » the five test homes. Overall, the builders have concluded that the energy related upgrades (either through the prescriptive or performance path) represent reasonable upgrades. The builders commented that while not every improvement in specification was cost effective (as in a reasonable payback period), many were improvements that could improve the marketability of the homes and serve to attract more energy efficiency discerning prospective homeowners. However, the builders did express reservations on the associated checklists and added certifications. An increase in administrative time was observed with all builders. The checklists and certifications also inherently increase cost due to: 1. Adding services to the scope of work for various trades, such as HERS Rater, HVAC contractor; 2. Increased material costs related to the checklists, especially the EPA Indoor airPLUS and EPA WaterSense(R) Efficient Hot Water Distribution requirement.« less

[Medical certificates: law, deontology and practice].

PubMed

Phillipart, Fr; Moulin, D; Pestiaux, D; Duyver, C

2007-01-01

At the start of the 21st century, in a society that gives the impression of switching century every five years because of its never-ending evolution, the general practitioner is confronted every day to more complex situations, including problems encountered at the legal level. These last few years, the legal interrogations relevant to medicine and its progress became considerably more extensive in Belgium, as in many other countries. The medical law and its regulation are the subject of many front titles in the press and of animated political debates. The main issues concern the organ transplantation, the meddling with human genetics, the questions related to the reproduction, euthanasia or the protection of the patient's rights. All these legal problems, without exception, are the subject of a great deal of attention in society and create to many controversies. The growing number of regulations in many fields of medicine, as well as their growing complexity, reinforces the importance of the medical law as a distinct discipline of legal sciences. More and more, the doctors of any qualification are required to guarantee, by adequate certificates, the health, the aptitude, the situation of disease of their patients. The patients can then have certain advantages granted by society. Out of concern for their patients, the experts are sometimes tempted not to be perfectly objective. This attitude can lead to penal or disciplinary sanctions and may undermine the confidence of people who exercise authority to give the requested advantages. The initial mistrust, which led to the system of the certificate, extends to those who were supposed to fully collaborate. How to leave this infernal round that sterilizes, denatures the medical act? While waiting for men of goodwill to consider the system and reform it, it remains with the writers of certificates to avoid the traps lying in their path. The purpose of this work is to propose models of certificate that experts can fill in accordance of the circumstances. It is only a guide and consequently, it sometimes requires an interpretation. This is why each model is described together with its justification and its traps.

Systematic Evaluation of Molecular Networks for Discovery of Disease Genes. | Office of Cancer Genomics

Cancer.gov

Gene networks are rapidly growing in size and number, raising the question of which networks are most appropriate for particular applications. Here, we evaluate 21 human genome-wide interaction networks for their ability to recover 446 disease gene sets identified through literature curation, gene expression profiling, or genome-wide association studies. While all networks have some ability to recover disease genes, we observe a wide range of performance with STRING, ConsensusPathDB, and GIANT networks having the best performance overall.

STS-105 Crew Interview: Pat Forrester

NASA Technical Reports Server (NTRS)

2001-01-01

STS-105 Mission Specialist Pat Forrester is seen during a prelaunch interview. He answers questions about his inspiration to become an astronaut, his career path, training for the mission, and his role in the mission's activities. He gives details on the mission's goals, which include the transfer of supplies from the Discovery Orbiter to the International Space Station (ISS) and the change-over of the Expedition 2 and Expedition 3 crews (the resident crews of ISS). Forrester discusses the importance of the ISS in the future of human spaceflight.

STS-105 Crew Interview: Rick Sturckow

NASA Technical Reports Server (NTRS)

2001-01-01

STS-105 Pilot Rick Sturckow is seen during a prelaunch interview. He answers questions about his inspiration to become an astronaut, his career path, training for the mission, and his role in the mission's activities. He gives details on the mission's goals, which include the transfer of supplies from the Discovery Orbiter to the International Space Station (ISS) and the change-over of the Expedition 2 and Expedition 3 crews (the resident crews of ISS). Sturckow discusses the importance of the ISS in the future of human spaceflight.

STS-105 Crew Interview: Scott Horowitz

NASA Technical Reports Server (NTRS)

2001-01-01

STS-105 Commander Scott Horowitz is seen during a prelaunch interview. He answers questions about his inspiration to become an astronaut, his career path, training for the mission, and his role in the mission's activities. He gives details on the mission's goals, which include the transfer of supplies from the Discovery Orbiter to the International Space Station (ISS) and the change-over of the Expedition 2 and Expedition 3 crews (the resident crews of ISS). Horowitz discusses the importance of the ISS in the future of human spaceflight.

Reverse and Forward Translational Neuropharmacology in Psychiatric Drug Discovery.

PubMed

Shaffer, Christopher L

2018-02-01

The probability of achieving marketing approval of a novel therapeutic for psychiatric indications is extremely low due largely to the inability to demonstrate durable and reproducible efficacy in phase II trials and beyond. These failures are often attributed to the lack of translation of the underlying neuropharmacology from animal model(s) to the disease population. However, how assured is such a conclusion considering the clinical efficacy path rarely meticulously parallels the preclinical experiment(s) that underwrote it? © 2017 American Society for Clinical Pharmacology and Therapeutics.

Dark matter in the coming decade: Complementary paths to discovery and beyond

DOE PAGES

Bauer, Daniel; Buckley, James; Cahill-Rowley, Matthew; ...

2015-05-27

Here, we summarize the many dark matter searches currently being pursued through four complementary approaches: direct detection, indirect detection, collider experiments, and astrophysical probes. The essential features of broad classes of experiments are described, each with their own strengths and weaknesses. Furthermore, we discuss the complementarity of the different dark matter searches qualitatively and illustrated quantitatively in two simple theoretical frameworks. Our primary conclusion is that the diversity of possible dark matter candidates requires a balanced program drawing from all four approaches.

STS-105 Crew Interview: Dan Barry

NASA Technical Reports Server (NTRS)

2001-01-01

STS-105 Mission Specialist Dan Barry is seen during a prelaunch interview. He answers questions about his inspiration to become an astronaut, his career path, training for the mission, and his role in the mission's activities. He gives details on the mission's goals, which include the transfer of supplies from the Discovery Orbiter to the International Space Station (ISS) and the change-over of the Expedition 2 and Expedition 3 crews (the resident crews of ISS). Barry discusses the importance of the ISS in the future of human spaceflight.

Science to Policy: Many Roads to Travel (Invited)

NASA Astrophysics Data System (ADS)

Eriksson, S. C.; McCaughey, J.

2013-12-01

Transferring scientific discoveries to policies and their implementation is not a narrow, one-way road. The complexities of policy-making are not normally within the purview of either scientists or science educators and communicators. Politics, bureaucracy, economics, culture, religion, and local knowledge are a few areas that help determine how policies are made. These factors are compounded by differences in cultures among scientists, educators/communicators, and governments. To complicate this further, bodies of knowledge which could be brought to bear upon improved policies and implementation lie within different disciplines, e.g. natural sciences, disaster risk reduction, development, psychology, social science, communications, education and more. In a scientific research institution, we have found many potential paths to help transfer knowledge back and forth between scientists and decision-makers. Some of these paths are short with an end in sight. Others are longer, and the destination can't be seen. Some of these paths include a) education and discussion with various government agencies, b) educating students who will return to various agencies and educational institutions in their home countries, c) sharing scientific knowledge with research colleagues, d) consulting, e) working with NGOs, and media, f) working with colleagues in other fields, e.g. development, risk, regional consortia. Recognizing and transferring knowledge among different disciplines, learning the needs of various players, finding the most productive paths, and thinking about varying time frames are important in prioritizing the transference of science into action.

Synergetic interaction between neighbouring platinum monomers in CO2 hydrogenation

NASA Astrophysics Data System (ADS)

Li, Hongliang; Wang, Liangbing; Dai, Yizhou; Pu, Zhengtian; Lao, Zhuohan; Chen, Yawei; Wang, Menglin; Zheng, Xusheng; Zhu, Junfa; Zhang, Wenhua; Si, Rui; Ma, Chao; Zeng, Jie

2018-05-01

Exploring the interaction between two neighbouring monomers has great potential to significantly raise the performance and deepen the mechanistic understanding of heterogeneous catalysis. Herein, we demonstrate that the synergetic interaction between neighbouring Pt monomers on MoS2 greatly enhanced the CO2 hydrogenation catalytic activity and reduced the activation energy relative to isolated monomers. Neighbouring Pt monomers were achieved by increasing the Pt mass loading up to 7.5% while maintaining the atomic dispersion of Pt. Mechanistic studies reveal that neighbouring Pt monomers not only worked in synergy to vary the reaction barrier, but also underwent distinct reaction paths compared with isolated monomers. Isolated Pt monomers favour the conversion of CO2 into methanol without the formation of formic acid, whereas CO2 is hydrogenated stepwise into formic acid and methanol for neighbouring Pt monomers. The discovery of the synergetic interaction between neighbouring monomers may create a new path for manipulating catalytic properties.

A Hybrid Computational Method for the Discovery of Novel Reproduction-Related Genes

PubMed Central

Chen, Lei; Chu, Chen; Kong, Xiangyin; Huang, Guohua; Huang, Tao; Cai, Yu-Dong

2015-01-01

Uncovering the molecular mechanisms underlying reproduction is of great importance to infertility treatment and to the generation of healthy offspring. In this study, we discovered novel reproduction-related genes with a hybrid computational method, integrating three different types of method, which offered new clues for further reproduction research. This method was first executed on a weighted graph, constructed based on known protein-protein interactions, to search the shortest paths connecting any two known reproduction-related genes. Genes occurring in these paths were deemed to have a special relationship with reproduction. These newly discovered genes were filtered with a randomization test. Then, the remaining genes were further selected according to their associations with known reproduction-related genes measured by protein-protein interaction score and alignment score obtained by BLAST. The in-depth analysis of the high confidence novel reproduction genes revealed hidden mechanisms of reproduction and provided guidelines for further experimental validations. PMID:25768094

A hybrid computational method for the discovery of novel reproduction-related genes.

PubMed

Chen, Lei; Chu, Chen; Kong, Xiangyin; Huang, Guohua; Huang, Tao; Cai, Yu-Dong

2015-01-01

Uncovering the molecular mechanisms underlying reproduction is of great importance to infertility treatment and to the generation of healthy offspring. In this study, we discovered novel reproduction-related genes with a hybrid computational method, integrating three different types of method, which offered new clues for further reproduction research. This method was first executed on a weighted graph, constructed based on known protein-protein interactions, to search the shortest paths connecting any two known reproduction-related genes. Genes occurring in these paths were deemed to have a special relationship with reproduction. These newly discovered genes were filtered with a randomization test. Then, the remaining genes were further selected according to their associations with known reproduction-related genes measured by protein-protein interaction score and alignment score obtained by BLAST. The in-depth analysis of the high confidence novel reproduction genes revealed hidden mechanisms of reproduction and provided guidelines for further experimental validations.

Leibniz on teleology and the laws of optics

NASA Astrophysics Data System (ADS)

McDonough, Jeffrey Keegan

This essay explores Leibniz's defense of teleology and teleological explanations in the domain of physics in general, and the roles that teleology plays in his studies of optics in particular. I argue first that Leibniz draws upon Plato's defense of final causes to introduce a novel research program intended to steer a middle course, on the one hand, between Aristotelian-Scholasticism and the new mechanical philosophy, and, on the other hand, between Cartesian rationalism and Gassendist empiricism. The implementation of this program leads Leibniz to significant conceptual innovations, as he attempts to reconcile teleological and efficient explanatory frameworks, and important discoveries, as he tries to show how final causes can be used to achieve results in the study of the natural world. Having situated Leibniz's defense of final causes in the broader context of his general philosophy of physics, I turn to a more detailed investigation of the roles that teleology plays in his work in geometrical optics. Interest in final causes leads Leibniz to introduce his "Most Determined Path Principle" from which both of the central laws of geometrical optics may be derived. I argue that Leibniz uses the discovery of such principles to introduce a thin notion of final causation within the order of nature based on teleological laws that link prior events to subsequent events via the likely or expected outcomes of those events, and defend this view against objections made both by Leibniz's contemporaries and our own. I also argue that Leibniz uses the discovery of principles like Most Determined Path Principle to provide a novel connection within his system between considerations of divine perfection and the laws of nature. I defend the internal consistency of this connection, and explore its relations to Leibniz's mature physics, and to his view that the world is governed by two sets of equipotent laws, one teleological and one mechanical.

Anticancer and other therapeutic relevance of mushroom polysaccharides: A holistic appraisal.

PubMed

Kothari, Damini; Patel, Seema; Kim, Soo-Ki

2018-06-01

The discovery of nutritious dietary supplements and side effect-free therapeutics are a priority in the current scenario of increasing instances of metabolic syndromes. In this direction, mushroom polysaccharides have shown immense promise. Scores of studies have characterized and evaluated their biological relevance, which range from antioxidant, anti-inflammatory, anticancer, antidiabetic, antimicrobial, and antilipemic to immunomodulatory. Hence, it is important to accumulate the key findings of these investigations, and to apply the insights to develop functional foods, and immunomodulators. This review attempts to meet this goal by gleaning the key discoveries on mushroom polysaccharides in the recent years, and to present them in a comprehensive manner. With this objective, the physiological relevance of the polysaccharides, the underlying mechanism, and hurdles in the path of their therapeutics transition, have been discussed. Finally, critical comments have been made to expedite research in this area. Copyright © 2018 Elsevier Masson SAS. All rights reserved.

Natural Products and Their Mimics as Targets of Opportunity for Discovery

PubMed Central

2017-01-01

Diverse structural types of natural products and their mimics have served as targets of opportunity in our laboratory to inspire the discovery and development of new methods and strategies to assemble polyfunctional and polycyclic molecular architectures. Furthermore, our efforts toward identifying novel compounds having useful biological properties led to the creation of new targets, many of which posed synthetic challenges that required the invention of new methodology. In this Perspective, selected examples of how we have exploited a diverse range of natural products and their mimics to create, explore, and solve a variety of problems in chemistry and biology will be discussed. The journey was not without its twists and turns, but the unexpected often led to new revelations and insights. Indeed, in our recent excursion into applications of synthetic organic chemistry to neuroscience, avoiding the more-traveled paths was richly rewarding. PMID:28738152

Climatic shocks associate with innovation in science and technology.

PubMed

De Dreu, Carsten K W; van Dijk, Mathijs A

2018-01-01

Human history is shaped by landmark discoveries in science and technology. However, across both time and space the rate of innovation is erratic: Periods of relative inertia alternate with bursts of creative science and rapid cascades of technological innovations. While the origins of the rise and fall in rates of discovery and innovation remain poorly understood, they may reflect adaptive responses to exogenously emerging threats and pressures. Here we examined this possibility by fitting annual rates of scientific discovery and technological innovation to climatic variability and its associated economic pressures and resource scarcity. In time-series data from Europe (1500-1900CE), we indeed found that rates of innovation are higher during prolonged periods of cold (versus warm) surface temperature and during the presence (versus absence) of volcanic dust veils. This negative temperature-innovation link was confirmed in annual time-series for France, Germany, and the United Kingdom (1901-1965CE). Combined, across almost 500 years and over 5,000 documented innovations and discoveries, a 0.5°C increase in temperature associates with a sizable 0.30-0.60 standard deviation decrease in innovation. Results were robust to controlling for fluctuations in population size. Furthermore, and consistent with economic theory and micro-level data on group innovation, path analyses revealed that the relation between harsher climatic conditions between 1500-1900CE and more innovation is mediated by climate-induced economic pressures and resource scarcity.

Data Science in Radiology: A Path Forward.

PubMed

Aerts, Hugo J W L

2018-02-01

Artificial intelligence (AI), especially deep learning, has the potential to fundamentally alter clinical radiology. AI algorithms, which excel in quantifying complex patterns in data, have shown remarkable progress in applications ranging from self-driving cars to speech recognition. The AI application within radiology, known as radiomics, can provide detailed quantifications of the radiographic characteristics of underlying tissues. This information can be used throughout the clinical care path to improve diagnosis and treatment planning, as well as assess treatment response. This tremendous potential for clinical translation has led to a vast increase in the number of research studies being conducted in the field, a number that is expected to rise sharply in the future. Many studies have reported robust and meaningful findings; however, a growing number also suffer from flawed experimental or analytic designs. Such errors could not only result in invalid discoveries, but also may lead others to perpetuate similar flaws in their own work. This perspective article aims to increase awareness of the issue, identify potential reasons why this is happening, and provide a path forward. Clin Cancer Res; 24(3); 532-4. ©2017 AACR . ©2017 American Association for Cancer Research.

Discovery and the Search for the Design of the Universe

NASA Astrophysics Data System (ADS)

Harwit, Martin

2012-09-01

Astronomers tend to think of their discoveries as part of a larger set of astronomical endeavors engaging their community at a particular time. That the complexion of discoveries is dependent on societal or economic factors, if recognized at all, is often considered a regrettable distraction from a logical path forward. Actually, the opposite is true: In the second half of the 20th century, astronomical discoveries were dominated by societal priorities. As World War II was ending, the United States embarked on a national program of post-war research that would seamlessly coordinate basic research in academic institutions with efforts to strengthen the nation's economy and military security. As part of this thrust, astronomy became driven by radio, infrared, X-ray, and gamma-ray discoveries, many initially made as part of military programs, before academic astronomers and astrophysicists adopted the new tools. Similarly coordinated national research programs also began to shape research in other nations. I will describe these arrangements before turning to two questions: 1) Can such coordinated national research programs survive into the 21st century, when most military institutions are loath to release classified information on sophisticated detection systems to the large international consortia required to share progressively mounting costs? 2) Has our vision of the Cosmos, today, been selectively shaped by the instrumentation made available to astronomy, through society's military and economic priorities? We need only think of how our concepts of the Universe have changed since the days when ground-based optical techniques were the sole means for probing the Universe.

Cryopreservation: Evolution of Molecular Based Strategies.

PubMed

Baust, John M; Corwin, William; Snyder, Kristi K; Van Buskirk, Robert; Baust, John G

2016-01-01

Cryopreservation (CP) is an enabling process providing for on-demand access to biological material (cells and tissues) which serve as a starting, intermediate or even final product. While a critical tool, CP protocols, approaches and technologies have evolved little over the last several decades. A lack of conversion of discoveries from the CP sciences into mainstream utilization has resulted in a bottleneck in technological progression in areas such as stem cell research and cell therapy. While the adoption has been slow, discoveries including molecular control and buffering of cell stress response to CP as well as the development of new devices for improved sample freezing and thawing are providing for improved CP from both the processing and sample quality perspectives. Numerous studies have described the impact, mechanisms and points of control of cryopreservation-induced delayed-onset cell death (CIDOCD). In an effort to limit CIDOCD, efforts have focused on CP agent and freeze media formulation to provide a solution path and have yielded improvements in survival over traditional approaches. Importantly, each of these areas, new technologies and cell stress modulation, both individually and in combination, are now providing a new foundation to accelerate new research, technology and product development for which CP serves as an integral component. This chapter provides an overview of the molecular stress responses of cells to cryopreservation, the impact of the hypothermic and cell death continuums and the targeted modulation of common and/or cell specific responses to CP in providing a path to improving cell quality.

The current status of education and career paths of students after completion of medical physicist programs in Japan: a survey by the Japanese Board for Medical Physicist Qualification.

PubMed

Kadoya, Noriyuki; Karasawa, Kumiko; Sumida, Iori; Arimura, Hidetaka; Yamada, Syogo

2015-07-01

To standardize educational programs and clinical training for medical physics students, the Japanese Board for Medical Physicist Qualification (JBMP) began to accredit master's, doctorate, and residency programs for medical physicists in 2012. At present, 16 universities accredited by the JBMP offer 22 courses. In this study, we aimed to survey the current status of educational programs and career paths of students after completion of the medical physicist program in Japan. A questionnaire was sent in August 2014 to 32 universities offering medical physicist programs. The questionnaire was created and organized by the educational course certification committee of the JBMP and comprised two sections: the first collected information about the university attended, and the second collected information about characteristics and career paths of students after completion of medical physicist programs from 2008 to 2014. Thirty universities (16 accredited and 14 non-accredited) completed the survey (response rate 94 %). A total of 209, 40, and 3 students graduated from the master's, doctorate, and residency programs, respectively. Undergraduates entered the medical physicist program constantly, indicating an interest in medical physics among undergraduates. A large percentage of the students held a bachelor's degree in radiological technology (master's program 94 %; doctorate program 70 %); graduates obtained a national radiological technologist license. Regarding career paths, although the number of the graduates who work as medical physicist remains low, 7 % with a master's degree and 50 % with a doctorate degree worked as medical physicists. Our results could be helpful for improving the medical physicist program in Japan.

A Mastery Rubric: guiding curriculum design, admissions and development of course objectives.

PubMed

Tractenberg, Rochelle E; Umans, Jason G; McCarter, Robert J

This article describes a 'Mastery Rubric' (MR) used to design both the curriculum and the assessments in a new two-year certificate programme intended to train physicians in clinical research skills. The MR for clinical research skills is built around a set of core research skills: critical review of literature; articulation of research objective; development of research design; development of analysis plan; implementation of the study; implementation of the analysis plan and presentation of results. Four distinct levels of performance are described for each skill: beginning, novice, competent and proficient. This rubric outlines and provides a path to mastery of the clinical research skills the certificate programme was designed and funded to target. Using the rubric to design the curriculum ensures that courses will provide instruction in key domains, promotes assessment that demonstrates development in the target skills and knowledge, and encourages reflection and cognitive self-monitoring in the students. It is a flexible, criterion-referenced definition of 'success' for students as well as the programme itself. The criteria are characterised in terms of the skills, habits of mind and organisational principles that can foster excellence in clinical research, but the approach can be generalised.

Novel tools for accelerated materials discovery in the AFLOWLIB.ORG repository: breakthroughs and challenges in the mapping of the materials genome

NASA Astrophysics Data System (ADS)

Buongiorno Nardelli, Marco

2015-03-01

High-Throughput Quantum-Mechanics computation of materials properties by ab initio methods has become the foundation of an effective approach to materials design, discovery and characterization. This data driven approach to materials science currently presents the most promising path to the development of advanced technological materials that could solve or mitigate important social and economic challenges of the 21st century. In particular, the rapid proliferation of computational data on materials properties presents the possibility to complement and extend materials property databases where the experimental data is lacking and difficult to obtain. Enhanced repositories such as AFLOWLIB, open novel opportunities for structure discovery and optimization, including uncovering of unsuspected compounds, metastable structures and correlations between various properties. The practical realization of these opportunities depends on the the design effcient algorithms for electronic structure simulations of realistic material systems, the systematic compilation and classification of the generated data, and its presentation in easily accessed form to the materials science community, the primary mission of the AFLOW consortium. This work was supported by ONR-MURI under Contract N00014-13-1-0635 and the Duke University Center for Materials Genomics.

From Mollusks to Medicine: A Venomics Approach for the Discovery and Characterization of Therapeutics from Terebridae Peptide Toxins.

PubMed

Verdes, Aida; Anand, Prachi; Gorson, Juliette; Jannetti, Stephen; Kelly, Patrick; Leffler, Abba; Simpson, Danny; Ramrattan, Girish; Holford, Mandë

2016-04-19

Animal venoms comprise a diversity of peptide toxins that manipulate molecular targets such as ion channels and receptors, making venom peptides attractive candidates for the development of therapeutics to benefit human health. However, identifying bioactive venom peptides remains a significant challenge. In this review we describe our particular venomics strategy for the discovery, characterization, and optimization of Terebridae venom peptides, teretoxins. Our strategy reflects the scientific path from mollusks to medicine in an integrative sequential approach with the following steps: (1) delimitation of venomous Terebridae lineages through taxonomic and phylogenetic analyses; (2) identification and classification of putative teretoxins through omics methodologies, including genomics, transcriptomics, and proteomics; (3) chemical and recombinant synthesis of promising peptide toxins; (4) structural characterization through experimental and computational methods; (5) determination of teretoxin bioactivity and molecular function through biological assays and computational modeling; (6) optimization of peptide toxin affinity and selectivity to molecular target; and (7) development of strategies for effective delivery of venom peptide therapeutics. While our research focuses on terebrids, the venomics approach outlined here can be applied to the discovery and characterization of peptide toxins from any venomous taxa.

Flying qualities design criteria applicable to supersonic cruise aircraft

NASA Technical Reports Server (NTRS)

Chalk, C. R.

1980-01-01

A comprehensive set of flying qualities design criteria was prepared for use in the supersonic cruise research program. The framework for stating the design criteria is established and design criteria are included which address specific failures, approach to dangerous flight conditions, flight at high angle of attack, longitudinal and lateral directional stability and control, the primary flight control system, and secondary flight controls. Examples are given of lateral directional design criteria limiting lateral accelerations at the cockpit, time to roll through 30 deg of bank, and time delay in the pilot's command path. Flight test data from the Concorde certification program are used to substantiate a number of the proposed design criteria.

In-Space Manufacturing: Pioneering a Sustainable Path to Mars

NASA Technical Reports Server (NTRS)

Werkheiser, Niki

2015-01-01

ISM is responsible for developing the on-demand manufacturing capabilities that will be required for affordable, sustainable operations during Exploration Missions (in-transit and on-surface) to destinations such as Mars. This includes advancing the needed technologies, as well as establishing the skills & processes (such as certification and characterization) that will enable the technologies to go from novel to institutionalized. These technologies are evolving rapidly due to terrestrial markets. ISM is leveraging this commercial development to develop these capabilities within a realistic timeframe and budget. ISM utilizes the International Space Station (ISS) as a test-bed to adapt these technologies for microgravity operations and evolve the current operations mindset from earth-reliant to earth-independent.

Development of a low risk augmentation system for an energy efficient transport having relaxed static stability

NASA Technical Reports Server (NTRS)

Sizlo, T. R.; Berg, R. A.; Gilles, D. L.

1979-01-01

An augmentation system for a 230 passenger, twin engine aircraft designed with a relaxation of conventional longitudinal static stability was developed. The design criteria are established and candidate augmentation system control laws and hardware architectures are formulated and evaluated with respect to reliability, flying qualities, and flight path tracking performance. The selected systems are shown to satisfy the interpreted regulatory safety and reliability requirements while maintaining the present DC 10 (study baseline) level of maintainability and reliability for the total flight control system. The impact of certification of the relaxed static stability augmentation concept is also estimated with regard to affected federal regulations, system validation plan, and typical development/installation costs.

Book Review: Caves and Karst of the Yorkshire Dales

NASA Astrophysics Data System (ADS)

Westaway, Rob

2015-10-01

The British Cave Research Association (BCRA) is the research division of the British Caving Association (BCA), itself the principal society in Britain for those interested in caving, with activities including provision of training and safety certification for cavers and managing access to caves. Although some UK cave-related research is carried out by academics, this tends to be restricted to archaeological investigations of caves that have served as human habitations, and to be focused more on the occupants than the caves themselves. In contrast, most cave exploration is undertaken as a leisure activity, under the auspices of clubs affiliated to the BCA/BCRA, this being indeed virtually the only field of Earth science where amateur investigators can continue to make significant discoveries. Many cave explorers are also affiliated with academic researchers, such as managers of dating laboratories; the synergy between these two groups is highly productive, having resulted for instance in the discovery and exploration in recent years of the vast Ogof Draenen cave system in South Wales, which probably dates back to the Early Pleistocene (e.g., Farrant et al., 2014).

Early postpartum: a critical period in setting the path for breastfeeding success.

PubMed

Gross, Susan M; Resnik, Amy K; Nanda, Joy P; Cross-Barnet, Caitlin; Augustyn, Marycatherine; Kelly, Linda; Paige, David M

2011-12-01

In the United States, most mothers who initiate breastfeeding will either stop or begin supplementing with formula before their infants are 3 months old. Routine breastfeeding education and support following hospital discharge are critical to breastfeeding success. The purpose of this article is to identify this critical period for supporting and reinforcing breastfeeding. We will use data from participants enrolled in the Maryland State Program of the U.S. Department of Agriculture's Supplemental Nutrition Program for Women, Infants, and Children (WIC). This cross-sectional study will explore whether breastfeeding patterns during the period between birth and postnatal WIC certification differ by participation in a local WIC agency that provides breastfeeding peer counselor support (PC) versus two comparison groups, the lactation consultant (LC) and standard care (SC) groups. During 2007, 33,582 infants were enrolled in the Maryland State WIC program. Infant breastfeeding status was categorized as exclusively breastfeeding, partially breastfeeding, or not breastfeeding. At certification, 30.4% of infants were breastfeeding, 25.3% had been breastfed but had stopped before certification in WIC, and 44.3% never breastfed. The breastfeeding initiation rate was higher for the PC group compared with the LC and SC groups (61.6% vs. 54.4% and 47.6%, respectively; p < 0.001). Participants in the PC group were more likely to certify as exclusively and partially breastfeeding compared with the LC and SC groups (36.0% vs. 24.8% and 25.3%, respectively; p < 0.001). Our analysis identifies a window of opportunity during which targeted contact with breastfeeding mothers could enhance longer-term breastfeeding rates.

Pursuing the unlimited potential of microorganisms-progress and prospect of a fermentation company.

PubMed

Arisawa, Akira; Watanabe, Azuma

2017-01-01

Production of pharmaceuticals and chemicals using microbial functions has bestowed numerous benefits onto society. The Nobel Prize awarded to Professor Ōmura, Distinguished Emeritus Professor of Kitasato University, showed the world the importance of the discovery and practical application of microorganisms. Now, increasing attention is turned toward the future path of this field. As people involved in the microorganism industry, we will review the industrial activities thus far and consider the possible future developments in this field and its potential contribution to society.

The Age of the First Nucleosynthesis in the Galaxy

NASA Astrophysics Data System (ADS)

Cayrel, R.; Hill, V.; Spite, M.; Spite, F.; François, P.; Depagne, E.; Nordström, B.; Andersen, J.; Plez, B.; Barbuy, B.; Beers, T.; Bonifacio, P.; Molaro, P.; Primas, F.

The observation of extremely metal-poor stars makes possible to obtain the epoch of formation of the first elements produced by massive supernovae, or hypernovae. The classical way of obtaining stellar ages (isochrone fitting) is unfortunately not applicable at present, as the distances of these stars are not known with enough accuracy. Dating by decay of radio-elements is another path, which has been renewed by the observation of uranium in the yellow giant CS 31082-001. We discuss the prospects opened by this discovery, and recent theoretical works triggered by this new opportunity.

Hepatoblastoma: A Need for Cell Lines and Tissue Banks to Develop Targeted Drug Therapies

PubMed Central

Rikhi, Rishi Raj; Spady, Kimberlee K.; Hoffman, Ruth I.; Bateman, Michael S.; Bateman, Max; Howard, Lisa Easom

2016-01-01

Limited research exists regarding the most aggressive forms of hepatoblastoma. Cell lines of the rare subtypes of hepatoblastoma with poor prognosis are not only difficult to attain but also challenging to characterize histologically. A community-driven approach to educating parents and families, regarding the need for donated tissue, is necessary for scientists to have access to resources for murine models and drug discovery. Herein, we describe the currently available resources, existing gaps in research, and the path to move forward for uniform cure of hepatoblastoma. PMID:27047905

Collaborating to improve the use of free-energy and other quantitative methods in drug discovery

NASA Astrophysics Data System (ADS)

Sherborne, Bradley; Shanmugasundaram, Veerabahu; Cheng, Alan C.; Christ, Clara D.; DesJarlais, Renee L.; Duca, Jose S.; Lewis, Richard A.; Loughney, Deborah A.; Manas, Eric S.; McGaughey, Georgia B.; Peishoff, Catherine E.; van Vlijmen, Herman

2016-12-01

In May and August, 2016, several pharmaceutical companies convened to discuss and compare experiences with Free Energy Perturbation (FEP). This unusual synchronization of interest was prompted by Schrödinger's FEP+ implementation and offered the opportunity to share fresh studies with FEP and enable broader discussions on the topic. This article summarizes key conclusions of the meetings, including a path forward of actions for this group to aid the accelerated evaluation, application and development of free energy and related quantitative, structure-based design methods.

Stem cell signaling as a target for novel drug discovery: recent progress in the WNT and Hedgehog pathways.

PubMed

An, Songzhu Michael; Ding, Qiang Peter; Li, Ling-song

2013-06-01

One of the most exciting fields in biomedical research over the past few years is stem cell biology, and therapeutic application of stem cells to replace the diseased or damaged tissues is also an active area in development. Although stem cell therapy has a number of technical challenges and regulatory hurdles to overcome, the use of stem cells as tools in drug discovery supported by mature technologies and established regulatory paths is expected to generate more immediate returns. In particular, the targeting of stem cell signaling pathways is opening up a new avenue for drug discovery. Aberrations in these pathways result in various diseases, including cancer, fibrosis and degenerative diseases. A number of drug targets in stem cell signaling pathways have been identified. Among them, WNT and Hedgehog are two most important signaling pathways, which are the focus of this review. A hedgehog pathway inhibitor, vismodegib (Erivedge), has recently been approved by the US FDA for the treatment of skin cancer, while several drug candidates for the WNT pathway are entering clinical trials. We have discovered that the stem cell signaling pathways respond to traditional Chinese medicines. Substances isolated from herbal medicine may act specifically on components of stem cell signaling pathways with high affinities. As many of these events can be explained through molecular interactions, these phenomena suggest that discovery of stem cell-targeting drugs from natural products may prove to be highly successful.

Climatic shocks associate with innovation in science and technology

PubMed Central

van Dijk, Mathijs A.

2018-01-01

Human history is shaped by landmark discoveries in science and technology. However, across both time and space the rate of innovation is erratic: Periods of relative inertia alternate with bursts of creative science and rapid cascades of technological innovations. While the origins of the rise and fall in rates of discovery and innovation remain poorly understood, they may reflect adaptive responses to exogenously emerging threats and pressures. Here we examined this possibility by fitting annual rates of scientific discovery and technological innovation to climatic variability and its associated economic pressures and resource scarcity. In time-series data from Europe (1500–1900CE), we indeed found that rates of innovation are higher during prolonged periods of cold (versus warm) surface temperature and during the presence (versus absence) of volcanic dust veils. This negative temperature–innovation link was confirmed in annual time-series for France, Germany, and the United Kingdom (1901–1965CE). Combined, across almost 500 years and over 5,000 documented innovations and discoveries, a 0.5°C increase in temperature associates with a sizable 0.30–0.60 standard deviation decrease in innovation. Results were robust to controlling for fluctuations in population size. Furthermore, and consistent with economic theory and micro-level data on group innovation, path analyses revealed that the relation between harsher climatic conditions between 1500–1900CE and more innovation is mediated by climate-induced economic pressures and resource scarcity. PMID:29364910

Paths and wakes of deformable nearly spheroidal rising bubbles close to the transition to path instability

NASA Astrophysics Data System (ADS)

Cano-Lozano, José Carlos; Martínez-Bazán, Carlos; Magnaudet, Jacques; Tchoufag, Joël

2016-09-01

We report on a series of results provided by three-dimensional numerical simulations of nearly spheroidal bubbles freely rising and deforming in a still liquid in the regime close to the transition to path instability. These results improve upon those of recent computational studies [Cano-Lozano et al., Int. J. Multiphase Flow 51, 11 (2013), 10.1016/j.ijmultiphaseflow.2012.11.005; Phys. Fluids 28, 014102 (2016), 10.1063/1.4939703] in which the neutral curve associated with this transition was obtained by considering realistic but frozen bubble shapes. Depending on the dimensionless parameters that characterize the system, various paths geometries are observed by letting an initially spherical bubble starting from rest rise under the effect of buoyancy and adjust its shape to the surrounding flow. These include the well-documented rectilinear axisymmetric, planar zigzagging, and spiraling (or helical) regimes. A flattened spiraling regime that most often eventually turns into either a planar zigzagging or a helical regime is also frequently observed. Finally, a chaotic regime in which the bubble experiences small horizontal displacements (typically one order of magnitude smaller than in the other regimes) is found to take place in a region of the parameter space where no standing eddy exists at the back of the bubble. The discovery of this regime provides evidence that path instability does not always result from a wake instability as previously believed. In each regime, we examine the characteristics of the path, bubble shape, and vortical structure in the wake, as well as their couplings. In particular, we observe that, depending on the fluctuations of the rise velocity, two different vortex shedding modes exist in the zigzagging regime, confirming earlier findings with falling spheres. The simulations also reveal that significant bubble deformations may take place along zigzagging or spiraling paths and that, under certain circumstances, they dramatically alter the wake structure. The instability thresholds that can be inferred from the computations compare favorably with experimental data provided by various sets of recent experiments guaranteeing that the bubble surface is free of surfactants.

DOE Zero Energy Ready Home Case Study: Amaris Custom Homes, St. Paul, Minnesota

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

For this project, Amaris worked with U.S. Department of Energy (DOE) team, NorthernSTAR Building America Partnership, to develop the first Zero Energy Ready Home (ZERH) in Minnesota's cold climate using reasonable, cost-effective, and replicable construction materials and practices. The result is a passive solar, super-efficient 3542-ft2 walkout ranch-style home with all the creature comforts. Along with meeting ZERH standards, Amaris also achieved certifications for Leadership in Energy & Environmental Design for Homes v4, MN Green Path Emerald, and a Builders Association of the Twin Cities Reggie Award of Excellence. The home achieves a HERS score of 41 without photovoltaics; withmore » PV, the home achieves a HERS score of 5.« less

A Mobility-Aware QoS Signaling Protocol for Ambient Networks

NASA Astrophysics Data System (ADS)

Jeong, Seong-Ho; Lee, Sung-Hyuck; Bang, Jongho

Mobility-aware quality of service (QoS) signaling is crucial to provide seamless multimedia services in the ambient environment where mobile nodes may move frequently between different wireless access networks. The mobility of an IP-based node in ambient networks affects routing paths, and as a result, can have a significant impact on the operation and state management of QoS signaling protocols. In this paper, we first analyze the impact of mobility on QoS signaling protocols and how the protocols operate in mobility scenarios. We then propose an efficient mobility-aware QoS signaling protocol which can operate adaptively in ambient networks. The key features of the protocol include the fast discovery of a crossover node where the old and new paths converge or diverge due to handover and the localized state management for seamless services. Our analytical and simulation/experimental results show that the proposed/implemented protocol works better than existing protocols in the IP-based mobile environment.

Scientific innovation's two Valleys of Death: how blood and tissue banks can help to bridge the gap.

PubMed

Thompson, Sean D A

2014-12-01

Most biomedical basic research in the United States takes place at universities and research institutes and is funded by federal grants. Basic research is awarded billions of federal dollars every year, enabling new discoveries and greater understanding of the fundamental science that makes new innovations and therapies possible. However, when basic research yields an invention of practical use and the research evolves from basic to applied, the playing field changes. Pre-technology licensing federal dollars all but disappear, and innovations rely predominantly on private funding to support the full path from bench to bedside. It is along this path that the scientific advance faces two Valleys of Death. These sometimes insurmountable development stages are the product of the innovation's inherent financial, business and investment risks. Well-planned and executed in vivo studies using quality biological materials demonstrating proof-of-concept is often the key to bridging these gaps, and blood and tissue banks offer unique services and resources to enable this process.

Dial-in Topological Metamaterials Based on Bistable Stewart Platform.

PubMed

Wu, Ying; Chaunsali, Rajesh; Yasuda, Hiromi; Yu, Kaiping; Yang, Jinkyu

2018-01-08

Recently, there have been significant efforts to guide mechanical energy in structures by relying on a novel topological framework popularized by the discovery of topological insulators. Here, we propose a topological metamaterial system based on the design of the Stewart Platform, which can not only guide mechanical waves robustly in a desired path, but also can be tuned in situ to change this wave path at will. Without resorting to any active materials, the current system harnesses bistablilty in its unit cells, such that tuning can be performed simply by a dial-in action. Consequently, a topological transition mechanism inspired by the quantum valley Hall effect can be achieved. We show the possibility of tuning in a variety of topological and traditional waveguides in the same system, and numerically investigate key qualitative and quantitative differences between them. We observe that even though both types of waveguides can lead to significant wave transmission for a certain frequency range, topological waveguides are distinctive as they support robust, back scattering immune, one-way wave propagation.

Multiple Smaller Missions as a Direct Pathway to Mars Sample Return

NASA Technical Reports Server (NTRS)

Niles, P. B.; Draper, D. S.; Evans, C. A.; Gibson, E. K.; Graham, L. D.; Jones, J. H.; Lederer, S. M.; Ming, D.; Seaman, C. H.; Archer, P. D.;

Luigi Galvani's path to animal electricity.

PubMed

Piccolino, Marco

2006-01-01

In spite of the historical importance of the research that, in the second half of the 18th century, led Luigi Galvani (1737-1798) to lay down the foundation of modern electrophysiology, his scientific personality is largely misrepresented in science history and in popular imagery. He is still considered as a pioneer that by chance incurred some surprising experimental observations and was incapable of pursuing his research in a coherent way. In contrast with these views, Galvani was a high-standard scientist who succeeded, with the strength of experimental science, in demonstrating, in animals, electricity in a condition of disequilibrium between the interior and the exterior of excitable fibres. This electricity, called 'animal electricity', was deemed responsible for nerve conduction. By studying the scientific endeavours of Galvani, through his published and unpublished material, and by situating them in the historical context of the physiology of the Enlightenment, this paper attempts to trace the elusive and complex path that led Galvani to his extraordinary discovery. To cite this article: M. Piccolino, C. R. Biologies 329 (2006).

Scientific Innovation's Two Valleys of Death: How Blood and Tissue Banks Can Help to Bridge the Gap

PubMed Central

Thompson, Sean D.A.

2014-01-01

Abstract Most biomedical basic research in the United States takes place at universities and research institutes and is funded by federal grants. Basic research is awarded billions of federal dollars every year, enabling new discoveries and greater understanding of the fundamental science that makes new innovations and therapies possible. However, when basic research yields an invention of practical use and the research evolves from basic to applied, the playing field changes. Pre-technology licensing federal dollars all but disappear, and innovations rely predominantly on private funding to support the full path from bench to bedside. It is along this path that the scientific advance faces two Valleys of Death. These sometimes insurmountable development stages are the product of the innovation’s inherent financial, business and investment risks. Well-planned and executed in vivo studies using quality biological materials demonstrating proof-of-concept is often the key to bridging these gaps, and blood and tissue banks offer unique services and resources to enable this process. PMID:25457967

Discovery of a Kiloparsec Extended Hard X-Ray Continuum and Fe-Kα from the Compton Thick AGN ESO 428-G014

NASA Astrophysics Data System (ADS)

Fabbiano, G.; Elvis, M.; Paggi, A.; Karovska, M.; Maksym, W. P.; Raymond, J.; Risaliti, G.; Wang, Junfeng

2017-06-01

We report the discovery of kiloparsec-scale diffuse emission in both the hard continuum (3-6 keV) and in the Fe-Kα line in the Compton thick (CT) Seyfert galaxy ESO 428-G014. This extended hard component contains at least ˜24% of the observed 3-8 keV emission, and follows the direction of the extended optical line emission (ionization cone) and radio jet. The extended hard component has ˜0.5% of the intrinsic 2-10 keV luminosity within the bi-cones. A uniform scattering medium of density 1 {{cm}}-3 would produce this luminosity in a 1 kpc path length in the bi-cones. Alternatively, higher column density molecular clouds in the disk of ESO 428-G014 may be responsible for these components. The continuum may also be enhanced by the acceleration of charged particles in the radio jet. The steeper spectrum (Γ ˜ 1.7 ± 0.4) of the hard continuum outside of the central 1.″5 radius nuclear region suggests a contribution of scattered/fluorescent intrinsic Seyfert emission. Ultrafast nuclear outflows cannot explain the extended Fe-Kα emission. This discovery suggests that we may need to revise the picture at the base of our interpretation of CT AGN spectra.

Stem cells in drug discovery, tissue engineering, and regenerative medicine: emerging opportunities and challenges.

PubMed

Nirmalanandhan, Victor Sanjit; Sittampalam, G Sitta

2009-08-01

Stem cells, irrespective of their origin, have emerged as valuable reagents or tools in human health in the past 2 decades. Initially, a research tool to study fundamental aspects of developmental biology is now the central focus of generating transgenic animals, drug discovery, and regenerative medicine to address degenerative diseases of multiple organ systems. This is because stem cells are pluripotent or multipotent cells that can recapitulate developmental paths to repair damaged tissues. However, it is becoming clear that stem cell therapy alone may not be adequate to reverse tissue and organ damage in degenerative diseases. Existing small-molecule drugs and biologicals may be needed as "molecular adjuvants" or enhancers of stem cells administered in therapy or adult stem cells in the diseased tissues. Hence, a combination of stem cell-based, high-throughput screening and 3D tissue engineering approaches is necessary to advance the next wave of tools in preclinical drug discovery. In this review, the authors have attempted to provide a basic account of various stem cells types, as well as their biology and signaling, in the context of research in regenerative medicine. An attempt is made to link stem cells as reagents, pharmacology, and tissue engineering as converging fields of research for the next decade.

Open Innovation Drug Discovery (OIDD): a potential path to novel therapeutic chemical space.

PubMed

Alvim-Gaston, Maria; Grese, Timothy; Mahoui, Abdelaziz; Palkowitz, Alan D; Pineiro-Nunez, Marta; Watson, Ian

2014-01-01

The continued development of computational and synthetic methods has enabled the enumeration or preparation of a nearly endless universe of chemical structures. Nevertheless, the ability of this chemical universe to deliver small molecules that can both modulate biological targets and have drug-like physicochemical properties continues to be a topic of interest to the pharmaceutical industry and academic researchers alike. The chemical space described by public, commercial, in-house and virtual compound collections has been interrogated by multiple approaches including biochemical, cellular and virtual screening, diversity analysis, and in-silico profiling. However, current drugs and known chemical probes derived from these efforts are contained within a remarkably small volume of the predicted chemical space. Access to more diverse classes of chemical scaffolds that maintain the properties relevant for drug discovery is certainly needed to meet the increasing demands for pharmaceutical innovation. The Lilly Open Innovation Drug Discovery platform (OIDD) was designed to tackle barriers to innovation through the identification of novel molecules active in relevant disease biology models. In this article we will discuss several computational approaches towards describing novel, biologically active, drug-like chemical space and illustrate how the OIDD program may facilitate access to previously untapped molecules that may aid in the search for innovative pharmaceuticals.

The impact of genetics on future drug discovery in schizophrenia.

PubMed

Matsumoto, Mitsuyuki; Walton, Noah M; Yamada, Hiroshi; Kondo, Yuji; Marek, Gerard J; Tajinda, Katsunori

2017-07-01

Failures of investigational new drugs (INDs) for schizophrenia have left huge unmet medical needs for patients. Given the recent lackluster results, it is imperative that new drug discovery approaches (and resultant drug candidates) target pathophysiological alterations that are shared in specific, stratified patient populations that are selected based on pre-identified biological signatures. One path to implementing this paradigm is achievable by leveraging recent advances in genetic information and technologies. Genome-wide exome sequencing and meta-analysis of single nucleotide polymorphism (SNP)-based association studies have already revealed rare deleterious variants and SNPs in patient populations. Areas covered: Herein, the authors review the impact that genetics have on the future of schizophrenia drug discovery. The high polygenicity of schizophrenia strongly indicates that this disease is biologically heterogeneous so the identification of unique subgroups (by patient stratification) is becoming increasingly necessary for future investigational new drugs. Expert opinion: The authors propose a pathophysiology-based stratification of genetically-defined subgroups that share deficits in particular biological pathways. Existing tools, including lower-cost genomic sequencing and advanced gene-editing technology render this strategy ever more feasible. Genetically complex psychiatric disorders such as schizophrenia may also benefit from synergistic research with simpler monogenic disorders that share perturbations in similar biological pathways.

Marketed Marine Natural Products in the Pharmaceutical and Cosmeceutical Industries: Tips for Success

PubMed Central

Martins, Ana; Vieira, Helena; Gaspar, Helena; Santos, Susana

2014-01-01

The marine environment harbors a number of macro and micro organisms that have developed unique metabolic abilities to ensure their survival in diverse and hostile habitats, resulting in the biosynthesis of an array of secondary metabolites with specific activities. Several of these metabolites are high-value commercial products for the pharmaceutical and cosmeceutical industries. The aim of this review is to outline the paths of marine natural products discovery and development, with a special focus on the compounds that successfully reached the market and particularly looking at the approaches tackled by the pharmaceutical and cosmetic companies that succeeded in marketing those products. The main challenges faced during marine bioactives discovery and development programs were analyzed and grouped in three categories: biodiversity (accessibility to marine resources and efficient screening), supply and technical (sustainable production of the bioactives and knowledge of the mechanism of action) and market (processes, costs, partnerships and marketing). Tips to surpass these challenges are given in order to improve the market entry success rates of highly promising marine bioactives in the current pipelines, highlighting what can be learned from the successful and unsuccessful stories that can be applied to novel and/or ongoing marine natural products discovery and development programs. PMID:24549205

Engagement of groups in family medicine board maintenance of certification.

PubMed

Fisher, Dena M; Brenner, Christopher J; Cheren, Mark; Stange, Kurt C

2013-01-01

The American Board of Medical Specialties' Performance in Practice ("Part IV") portion of Maintenance of Certification (MOC) requirement provides an opportunity for practicing physicians to demonstrate quality improvement (QI) competence. However, specialty boards' certification of one physician at a time does not tap into the potential of collective effort. This article shares learning from a project to help family physicians work in groups to meet their Part IV MOC requirement. A year-long implementation and evaluation project was conducted. Initially, 348 members of a regional family physician organization were invited to participate. A second path was established through 3 health care systems and a county-wide learning collaborative. Participants were offered (1) a basic introduction to QI methods, (2) the option of an alternative Part IV MOC module using a patient experience survey to guide QI efforts, (3) practice-level improvement coaching, (4) support for collaboration and co-learning, and (5) provision of QI resources. More physicians participated through group (66) than individual (12) recruitment, for a total of 78 physicians in 20 practices. Participation occurred at 3 levels: individual, intrapractice, and interpractice. Within the 1-year time frame, intrapractice collaboration occurred most frequently. Interpractice and system-level collaboration has begun and continues to evolve. Physicians felt that they benefited from access to a practice coach and group process. Practice-level collaboration, access to a practice coach, flexibility in choosing and focusing improvement projects, tailored support, and involvement with professional affiliations can enhance the Part IV MOC process. Specialty boards are likely to discover productive opportunities from working with practices, professional organizations, and health care systems to support intra- and interpractice collaborative QI work that uses Part IV MOC requirements to motivate practice improvement.

Continuous Improvement and the Safety Case for the Waste Isolation Pilot Plant Geologic Repository - 13467

DOE Office of Scientific and Technical Information (OSTI.GOV)

Van Luik, Abraham; Patterson, Russell; Nelson, Roger

2013-07-01

The Waste Isolation Pilot Plant (WIPP) is a geologic repository 2150 feet (650 m) below the surface of the Chihuahuan desert near Carlsbad, New Mexico. WIPP permanently disposes of transuranic waste from national defense programs. Every five years, the U.S. Department of Energy (DOE) submits an application to the U.S. Environmental Protection Agency (EPA) to request regulatory-compliance re-certification of the facility for another five years. Every ten years, DOE submits an application to the New Mexico Environment Department (NMED) for the renewal of its hazardous waste disposal permit. The content of the applications made by DOE to the EPA formore » re-certification, and to the NMED for permit-renewal, reflect any optimization changes made to the facility, with regulatory concurrence if warranted by the nature of the change. DOE points to such changes as evidence for its having taken seriously its 'continuous improvement' operations and management philosophy. Another opportunity for continuous improvement is to look at any delta that may exist between the re-certification and re-permitting cases for system safety and the consensus advice on the nature and content of a safety case as being developed and published by the Nuclear Energy Agency's Integration Group for the Safety Case (IGSC) expert group. DOE at WIPP, with the aid of its Science Advisor and teammate, Sandia National Laboratories, is in the process of discerning what can be done, in a reasonably paced and cost-conscious manner, to continually improve the case for repository safety that is being made to the two primary regulators on a recurring basis. This paper will discuss some aspects of that delta and potential paths forward to addressing them. (authors)« less

Self-assembling peptide nanofiber hydrogels in tissue engineering and regenerative medicine: Progress, design guidelines, and applications.

PubMed

Koutsopoulos, Sotirios

2016-04-01

Until the mid-1980s, mainly biologists were conducting peptide research. This changed with discoveries that opened new paths of research involving the use of peptides in bioengineering, biotechnology, biomedicine, nanotechnology, and bioelectronics. Peptide engineering and rational design of novel peptide sequences with unique and tailor-made properties further expanded the field. The discovery of short self-assembling peptides, which upon association form well-defined supramolecular architectures, created new and exciting areas of research. Depending on the amino acid sequence, the pH, and the type of the electrolyte in the medium, peptide self-assembly leads to the formation of nanofibers, which are further organized to form a hydrogel. In this review, the application of ionic complementary peptides which self-assemble to form nanofiber hydrogels for tissue engineering and regenerative medicine will be discussed through a selective presentation of the most important work performed during the last 25 years. © 2016 Wiley Periodicals, Inc.

Systematic Evaluation of Molecular Networks for Discovery of Disease Genes.

PubMed

Huang, Justin K; Carlin, Daniel E; Yu, Michael Ku; Zhang, Wei; Kreisberg, Jason F; Tamayo, Pablo; Ideker, Trey

2018-04-25

Gene networks are rapidly growing in size and number, raising the question of which networks are most appropriate for particular applications. Here, we evaluate 21 human genome-wide interaction networks for their ability to recover 446 disease gene sets identified through literature curation, gene expression profiling, or genome-wide association studies. While all networks have some ability to recover disease genes, we observe a wide range of performance with STRING, ConsensusPathDB, and GIANT networks having the best performance overall. A general tendency is that performance scales with network size, suggesting that new interaction discovery currently outweighs the detrimental effects of false positives. Correcting for size, we find that the DIP network provides the highest efficiency (value per interaction). Based on these results, we create a parsimonious composite network with both high efficiency and performance. This work provides a benchmark for selection of molecular networks in human disease research. Copyright © 2018 Elsevier Inc. All rights reserved.

Synthetic Biomaterials to Rival Nature's Complexity-a Path Forward with Combinatorics, High-Throughput Discovery, and High-Content Analysis.

PubMed

Zhang, Douglas; Lee, Junmin; Kilian, Kristopher A

2017-10-01

Cells in tissue receive a host of soluble and insoluble signals in a context-dependent fashion, where integration of these cues through a complex network of signal transduction cascades will define a particular outcome. Biomaterials scientists and engineers are tasked with designing materials that can at least partially recreate this complex signaling milieu towards new materials for biomedical applications. In this progress report, recent advances in high throughput techniques and high content imaging approaches that are facilitating the discovery of efficacious biomaterials are described. From microarrays of synthetic polymers, peptides and full-length proteins, to designer cell culture systems that present multiple biophysical and biochemical cues in tandem, it is discussed how the integration of combinatorics with high content imaging and analysis is essential to extracting biologically meaningful information from large scale cellular screens to inform the design of next generation biomaterials. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

The Search for Life Beyond Earth

NASA Image and Video Library

2014-07-14

Panelists (from left) Ellen Stofan, NASA Chief Scientist, left; John Grunsfeld, Associate Administrator for NASA's Science Mission DIrectorate, second from left; John Mather, Nobel Laureate and Senior Project Scientist for the James Webb Space Telescope (JWST) at NASA's Goddard Space Flight Center, third from left; Sara Seager, MacArthur Fellow and Professor of Planetary Science and Physics at the Massachusetts Institute of Technology, third from right; Dave Gallagher, Director for Astronomy and Physics at NASA's Jet Propulsion Laboratory, second from right; and Matt Mountain, Director of the Space Telescope Science Institute and Telescope Scientist for the JWST, right; are seen during a panel discussion on the search for life beyond Earth in the James E. Webb Auditorium at NASA Headquarters on Monday, July 14, 2014 in Washington, DC. The panel discussed how NASA's space-based observatories are making new discoveries and how the agency's new telescope, the James Webb Space Telescope, will continue this path of discovery after its schedule launch in 2018. Photo Credit: (NASA/Joel Kowsky)

Terrain discovery and navigation of a multi-articulated linear robot using map-seeking circuits

NASA Astrophysics Data System (ADS)

Snider, Ross K.; Arathorn, David W.

2006-05-01

A significant challenge in robotics is providing a robot with the ability to sense its environment and then autonomously move while accommodating obstacles. The DARPA Grand Challenge, one of the most visible examples, set the goal of driving a vehicle autonomously for over a hundred miles avoiding obstacles along a predetermined path. Map-Seeking Circuits have shown their biomimetic capability in both vision and inverse kinematics and here we demonstrate their potential usefulness for intelligent exploration of unknown terrain using a multi-articulated linear robot. A robot that could handle any degree of terrain complexity would be useful for exploring inaccessible crowded spaces such as rubble piles in emergency situations, patrolling/intelligence gathering in tough terrain, tunnel exploration, and possibly even planetary exploration. Here we simulate autonomous exploratory navigation by an interaction of terrain discovery using the multi-articulated linear robot to build a local terrain map and exploitation of that growing terrain map to solve the propulsion problem of the robot.

A new ophiovirus is associated with blueberry mosaic disease.

PubMed

Thekke-Veetil, Thanuja; Ho, Thien; Keller, Karen E; Martin, Robert R; Tzanetakis, Ioannis E

2014-08-30

Blueberry mosaic disease (BMD) was first described more than 60 years ago and is caused by a yet unidentified graft transmissible agent. A combination of traditional methods and next generation sequencing disclosed the presence of a new ophiovirus in symptomatic plants. The virus was detected in all BMD samples collected from several production areas of North America and was thus named blueberry mosaic associated virus. Phylogenetic analysis, supported by high bootstrap values, places the virus within the family Ophioviridae. The genome organization resembles that of citrus psorosis virus, the type member of the genus Ophiovirus. The implications of this discovery in BMD control and blueberry virus certification schemes are also discussed. Copyright © 2014 Elsevier B.V. All rights reserved.

Jupiter's Auroras Acceleration Processes

NASA Image and Video Library

2017-09-06

This image, created with data from Juno's Ultraviolet Imaging Spectrometer (UVS), marks the path of Juno's readings of Jupiter's auroras, highlighting the electron measurements that show the discovery of the so-called discrete auroral acceleration processes indicated by the "inverted Vs" in the lower panel (Figure 1). This signature points to powerful magnetic-field-aligned electric potentials that accelerate electrons toward the atmosphere to energies that are far greater than what drive the most intense aurora at Earth. Scientists are looking into why the same processes are not the main factor in Jupiter's most powerful auroras. https://photojournal.jpl.nasa.gov/catalog/PIA21937

Two-photon excitation fluorescence bioassays.

PubMed

Hänninen, Pekka; Soukka, Jori; Soini, Juhani T

2008-01-01

Application of two-photon excitation of fluorescence in microscopy is one of the major discoveries of the "renaissance" of light microscopy that started in the 1980s. The technique derives its advantages from the biologically "smooth" wavelength of the excitation light and the confinement of the excitation. Difficult, and seemingly nontransparent, samples may be imaged with the technique with good resolution. Although the bioresearch has been concentrating mostly on the positive properties of the technique for imaging, the same properties may be applied successfully to nonimaging bioassays. This article focuses on the development path of two-photon excitation-based assay system.

It's a wonderful life: a career as an academic scientist.

PubMed

Vale, Ronald D

2010-01-01

Many years of training are required to obtain a job as an academic scientist. Is this investment of time and effort worthwhile? My answer is a resounding "yes." Academic scientists enjoy tremendous freedom in choosing their research and career path, experience unusual camaraderie in their lab, school, and international community, and can contribute to and enjoy being part of this historical era of biological discovery. In this essay, I further elaborate by listing my top ten reasons why an academic job is a desirable career for young people who are interested in the life sciences.

jsc2018m000274_Alpha-Space-Small-Business-Makes-Big-Strides_MP4

NASA Image and Video Library

2018-03-30

The path to discovery and exploration is paved with determination, innovation, and most of all, big ideas. The International Space Station is home to many of those ideas and creating new ways for small businesses, entrepreneurs and researchers to test their science and technology in space every day.Formed in 2015 in response to the need for a commercial payload that would be available to private companies aboard the space station, Alpha Space is a woman- and minority-owned small business responsible for developing the Materials International Space Station Experiment Flight Facility (MISSE-FF).

Computational Psychiatry and the Challenge of Schizophrenia.

PubMed

Krystal, John H; Murray, John D; Chekroud, Adam M; Corlett, Philip R; Yang, Genevieve; Wang, Xiao-Jing; Anticevic, Alan

2017-05-01

Schizophrenia research is plagued by enormous challenges in integrating and analyzing large datasets and difficulties developing formal theories related to the etiology, pathophysiology, and treatment of this disorder. Computational psychiatry provides a path to enhance analyses of these large and complex datasets and to promote the development and refinement of formal models for features of this disorder. This presentation introduces the reader to the notion of computational psychiatry and describes discovery-oriented and theory-driven applications to schizophrenia involving machine learning, reinforcement learning theory, and biophysically-informed neural circuit models. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center 2017.

Education and training of future wetland scientists and managers

USGS Publications Warehouse

Wilcox, D.A.

2008-01-01

Wetland science emerged as a distinct discipline in the 1980s. In response, courses addressing various aspects of wetland science and management were developed by universities, government agencies, and private firms. Professional certification of wetland scientists began in the mid-1990s to provide confirmation of the quality of education and experience of persons involved in regulatory, management, restoration/construction, and research involving wetland resources. The education requirements for certification and the need for persons with specific wetland training to fill an increasing number of wetland-related positions identified a critical need to develop curriculum guidelines for an undergraduate wetland science and management major for potential accreditation by the Society of Wetland Scientists. That proposed major contains options directed toward either wetland science or management. Both options include required basic courses to meet the general education requirements of many universities, required upper-level specialized courses that address critical aspects of physical and biological sciences applicable to wetlands, and a minimum of four additional upper-level specialized courses that can be used to tailor a degree to students' interests. The program would be administered by an independent review board that would develop guidelines and evaluate university applications for accreditation. Students that complete the required coursework will fulfill the education requirements for professional wetland scientist certification and possess qualifications that make them attractive candidates for graduate school or entry-level positions in wetland science or management. Universities that offer this degree program could gain an advantage in recruiting highly qualified students with an interest in natural resources. Alternative means of educating established wetland scientists are likewise important, especially to provide specialized knowledge and experience or updates related to new management discoveries, policies, and regulations. ?? 2008 The Society of Wetland Scientists.

Lawrence Livermore National Laboratory- Completing the Human Genome Project and Triggering Nearly $1 Trillion in U.S. Economic Activity

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stewart, Jeffrey S.

The success of the Human Genome project is already nearing $1 Trillion dollars of U.S. economic activity. Lawrence Livermore National Laboratory (LLNL) was a co-leader in one of the biggest biological research effort in history, sequencing the Human Genome Project. This ambitious research effort set out to sequence the approximately 3 billion nucleotides in the human genome, an effort many thought was nearly impossible. Deoxyribonucleic acid (DNA) was discovered in 1869, and by 1943 came the discovery that DNA was a molecule that encodes the genetic instructions used in the development and functioning of living organisms and many viruses. Tomore » make full use of the information, scientists needed to first sequence the billions of nucleotides to begin linking them to genetic traits and illnesses, and eventually more effective treatments. New medical discoveries and improved agriculture productivity were some of the expected benefits. While the potential benefits were vast, the timeline (over a decade) and cost ($3.8 Billion) exceeded what the private sector would normally attempt, especially when this would only be the first phase toward the path to new discoveries and market opportunities. The Department of Energy believed its best research laboratories could meet this Grand Challenge and soon convinced the National Institute of Health to formally propose the Human Genome project to the federal government. The U.S. government accepted the risk and challenge to potentially create new healthcare and food discoveries that could benefit the world and the U.S. Industry.« less

Regulators of G-protein signaling and their Gα substrates: promises and challenges in their use as drug discovery targets.

PubMed

Kimple, Adam J; Bosch, Dustin E; Giguère, Patrick M; Siderovski, David P

2011-09-01

Because G-protein coupled receptors (GPCRs) continue to represent excellent targets for the discovery and development of small-molecule therapeutics, it is posited that additional protein components of the signal transduction pathways emanating from activated GPCRs themselves are attractive as drug discovery targets. This review considers the drug discovery potential of two such components: members of the "regulators of G-protein signaling" (RGS protein) superfamily, as well as their substrates, the heterotrimeric G-protein α subunits. Highlighted are recent advances, stemming from mouse knockout studies and the use of "RGS-insensitivity" and fast-hydrolysis mutations to Gα, in our understanding of how RGS proteins selectively act in (patho)physiologic conditions controlled by GPCR signaling and how they act on the nucleotide cycling of heterotrimeric G-proteins in shaping the kinetics and sensitivity of GPCR signaling. Progress is documented regarding recent activities along the path to devising screening assays and chemical probes for the RGS protein target, not only in pursuits of inhibitors of RGS domain-mediated acceleration of Gα GTP hydrolysis but also to embrace the potential of finding allosteric activators of this RGS protein action. The review concludes in considering the Gα subunit itself as a drug target, as brought to focus by recent reports of activating mutations to GNAQ and GNA11 in ocular (uveal) melanoma. We consider the likelihood of several strategies for antagonizing the function of these oncogene alleles and their gene products, including the use of RGS proteins with Gα(q) selectivity.

Final Technical Report for ``Paths to Discovery at the LHC : Dark Matter and Track Triggering"

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hahn, Kristian

Particle Dark Matter (DM) is perhaps the most compelling and experimentally well-motivated new physics scenario anticipated at the Large Hadron Collider (LHC). The DE-SC0014073 award allowed the PI to define and pursue a path to the discovery of Dark Matter in Run-2 of the LHC with the Compact Muon Solenoid (CMS) experiment. CMS can probe regions of Dark Matter phase-space that direct and indirect detection experiments are unable to constrain. The PI’s team initiated the exploration of these regions, searching specifically for the associated production of Dark Matter with top quarks. The effort focuses on the high-yield, hadronic decays ofmore » W bosons produced in top decay, which provides the highest sensitivity to DM produced via through low-mass spin-0 mediators. The group developed identification algorithms that achieve high efficiency and purity in the selection of hadronic top decays, and analysis techniques that provide powerful signal discrimination in Run-2. The ultimate reach of new physics searches with CMS will be established at the high-luminosity LHC (HL-LHC). To fully realize the sensitivity the HL-LHC promises, CMS must minimize the impact of soft, inelastic (“pileup”) interactions on the real-time “trigger” system the experiment uses for data refinement. Charged particle trajectory information (“tracking”) will be essential for pileup mitigation at the HL-LHC. The award allowed the PI’s team to develop firmware-based data delivery and track fitting algorithms for an unprecedented, real-time tracking trigger to sustain the experiment’s sensitivity to new physics in the next decade.« less

Drosophila learn efficient paths to a food source.

PubMed

Navawongse, Rapeechai; Choudhury, Deepak; Raczkowska, Marlena; Stewart, James Charles; Lim, Terrence; Rahman, Mashiur; Toh, Alicia Guek Geok; Wang, Zhiping; Claridge-Chang, Adam

2016-05-01

Elucidating the genetic, and neuronal bases for learned behavior is a central problem in neuroscience. A leading system for neurogenetic discovery is the vinegar fly Drosophila melanogaster; fly memory research has identified genes and circuits that mediate aversive and appetitive learning. However, methods to study adaptive food-seeking behavior in this animal have lagged decades behind rodent feeding analysis, largely due to the challenges presented by their small scale. There is currently no method to dynamically control flies' access to food. In rodents, protocols that use dynamic food delivery are a central element of experimental paradigms that date back to the influential work of Skinner. This method is still commonly used in the analysis of learning, memory, addiction, feeding, and many other subjects in experimental psychology. The difficulty of microscale food delivery means this is not a technique used in fly behavior. In the present manuscript we describe a microfluidic chip integrated with machine vision and automation to dynamically control defined liquid food presentations and sensory stimuli. Strikingly, repeated presentations of food at a fixed location produced improvements in path efficiency during food approach. This shows that improved path choice is a learned behavior. Active control of food availability using this microfluidic system is a valuable addition to the methods currently available for the analysis of learned feeding behavior in flies. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

Identification of conserved lipid/detergent-binding sites in a high-resolution structure of the membrane protein cytochrome c oxidase

PubMed Central

Qin, Ling; Hiser, Carrie; Mulichak, Anne; Garavito, R. Michael; Ferguson-Miller, Shelagh

2006-01-01

Well ordered reproducible crystals of cytochrome c oxidase (CcO) from Rhodobacter sphaeroides yield a previously unreported structure at 2.0 Å resolution that contains the two catalytic subunits and a number of alkyl chains of lipids and detergents. Comparison with crystal structures of other bacterial and mammalian CcOs reveals that the positions occupied by native membrane lipids and detergent substitutes are highly conserved, along with amino acid residues in their vicinity, suggesting a more prevalent and specific role of lipid in membrane protein structure than often envisioned. Well defined detergent head groups (maltose) are found associated with aromatic residues in a manner similar to phospholipid head groups, likely contributing to the success of alkyl glycoside detergents in supporting membrane protein activity and crystallizability. Other significant features of this structure include the following: finding of a previously unreported crystal contact mediated by cadmium and an engineered histidine tag; documentation of the unique His–Tyr covalent linkage close to the active site; remarkable conservation of a chain of waters in one proton pathway (D-path); and discovery of an inhibitory cadmium-binding site at the entrance to another proton path (K-path). These observations provide important insight into CcO structure and mechanism, as well as the significance of bound lipid in membrane proteins. PMID:17050688

Path toward economic resilience for family caregivers: mitigating household deprivation and the health care talent shortage at the same time.

PubMed

Simon, Melissa A; Gunia, Brian; Martin, Emily J; Foucar, Charles E; Kundu, Tapas; Ragas, Daiva M; Emanuel, Linda L

2013-10-01

Rising costs and a workforce talent shortage are two of the health care industry's most pressing challenges. In particular, serious illnesses often impose significant costs on individuals and their families, which can place families at an increased risk for multigenerational economic deprivation or even an illness-poverty trap. At the same time, family caregivers often acquire a wide variety of health care skills that neither these caregivers nor the health care industry typically use. As these skills are marketable and could be paired with many existing medical certifications, this article describes a possible "path toward economic resilience" (PER) through a program whereby family caregivers could find meaningful employment using their new skills. The proposed program would identify ideal program candidates, assess and supplement their competencies, and connect them to the health care industry. We provide a set of practical steps and recommended tools for implementation, discuss pilot data on the program's appeal and feasibility, and raise several considerations for program development and future research. Our analysis suggests that this PER program could appeal to family caregivers and the health care industry alike, possibly helping to address two of our health care system's most pressing challenges with one solution.

Path Toward Economic Resilience for Family Caregivers: Mitigating Household Deprivation and the Health Care Talent Shortage at the Same Time

PubMed Central

Simon, Melissa A.

2013-01-01

Rising costs and a workforce talent shortage are two of the health care industry’s most pressing challenges. In particular, serious illnesses often impose significant costs on individuals and their families, which can place families at an increased risk for multigenerational economic deprivation or even an illness–poverty trap. At the same time, family caregivers often acquire a wide variety of health care skills that neither these caregivers nor the health care industry typically use. As these skills are marketable and could be paired with many existing medical certifications, this article describes a possible “path toward economic resilience” (PER) through a program whereby family caregivers could find meaningful employment using their new skills. The proposed program would identify ideal program candidates, assess and supplement their competencies, and connect them to the health care industry. We provide a set of practical steps and recommended tools for implementation, discuss pilot data on the program’s appeal and feasibility, and raise several considerations for program development and future research. Our analysis suggests that this PER program could appeal to family caregivers and the health care industry alike, possibly helping to address two of our health care system’s most pressing challenges with one solution. PMID:23633216

Materials Genome Initiative

NASA Technical Reports Server (NTRS)

Vickers, John

2015-01-01

The Materials Genome Initiative (MGI) project element is a cross-Center effort that is focused on the integration of computational tools to simulate manufacturing processes and materials behavior. These computational simulations will be utilized to gain understanding of processes and materials behavior to accelerate process development and certification to more efficiently integrate new materials in existing NASA projects and to lead to the design of new materials for improved performance. This NASA effort looks to collaborate with efforts at other government agencies and universities working under the national MGI. MGI plans to develop integrated computational/experimental/ processing methodologies for accelerating discovery and insertion of materials to satisfy NASA's unique mission demands. The challenges include validated design tools that incorporate materials properties, processes, and design requirements; and materials process control to rapidly mature emerging manufacturing methods and develop certified manufacturing processes

The History of Cortisone Discovery and Development.

PubMed

Burns, Christopher M

2016-02-01

Philip Hench, Edward Kendall, and Tadeus Reichstein received the Nobel Prize in medicine and physiology in 1950 for their "investigations of the hormones of the adrenal cortex." Hench and Kendall took compound E from the laboratory to the clinic to the Nobel Prize in a span of 2 years. This article examines the paths that led to the day when the first rheumatoid arthritis patient received cortisone, and from there to the 1950 Nobel Prize ceremony. The aftermath of this achievement is also discussed. Although there have been significant advances in corticosteroid preparations and use since 1950, the side effects remain daunting. Copyright © 2016 Elsevier Inc. All rights reserved.

Overview of cancer vaccines

PubMed Central

Kudrin, Alex

2012-01-01

Cancer immunotherapy has seen a tremendous number of failures and only few recent regulatory successes. This is a review dedicated to determine major regulatory and developmental issues around cancer immunotherapeutics. A three pillar approach should be used in setting a development path: discovery platforms and sufficient pool of validated tumor antigens, product development strategy enabling to bring the product closer to the patient and clinical development strategy accounting for competitive landscape, treatment paradigm, technical and commercial risks. Regulatory framework existing around cancer vaccines in the EU, US, Japan and some developing countries is outlined. In addition, the review covers some specific issues on the design and conduct of clinical trials with cancer vaccines. PMID:22894970

Science of science.

PubMed

Fortunato, Santo; Bergstrom, Carl T; Börner, Katy; Evans, James A; Helbing, Dirk; Milojević, Staša; Petersen, Alexander M; Radicchi, Filippo; Sinatra, Roberta; Uzzi, Brian; Vespignani, Alessandro; Waltman, Ludo; Wang, Dashun; Barabási, Albert-László

2018-03-02

Identifying fundamental drivers of science and developing predictive models to capture its evolution are instrumental for the design of policies that can improve the scientific enterprise-for example, through enhanced career paths for scientists, better performance evaluation for organizations hosting research, discovery of novel effective funding vehicles, and even identification of promising regions along the scientific frontier. The science of science uses large-scale data on the production of science to search for universal and domain-specific patterns. Here, we review recent developments in this transdisciplinary field. Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

A Perspective of the future of nuclear medicine training and certification

PubMed Central

Arevalo-Perez, Julio; Paris, Manuel; Graham, Michael M.; Osborne, Joseph R.

2016-01-01

Nuclear Medicine has evolved from a medical subspecialty using quite basic tests to one using elaborate methods to image organ physiology and has truly become “Molecular Imaging”. Concurrently, there has also been a timely debate about who has to be responsible for keeping pace with all of the components of the developmental cycle; imaging, radiopharmaceuticals and instrumentation. Since the foundation of the ABNM, the practice of Nuclear Medicine and the process toward certification have undergone major revisions. At present, the debate is focused on the inevitable future convergence of Radiology and Nuclear Medicine. The potential for further cooperation or fusion of the American Board of Radiology (ABR) and the American Board of Nuclear Medicine (ABNM) is likely to bring about a new path for Nuclear Medicine and Molecular Imaging training. If the merger is done carefully, respecting the strengths of both partners equally, there is an excellent potential to create a hybrid Nuclear Medicine – Radiology specialty that combines Physiology and Molecular Biology with detailed anatomic imaging that will sustain the innovation that has been central to nuclear medicine residency and practice. Herein, we also introduce a few basic trends in imaging utilization in the United States. These trends do not predict future utilization, but highlight the need for an appropriately credentialed practitioner to interpret these examinations and provide value to the healthcare system. PMID:26687859

Fragment based drug discovery: practical implementation based on ¹⁹F NMR spectroscopy.

PubMed

Jordan, John B; Poppe, Leszek; Xia, Xiaoyang; Cheng, Alan C; Sun, Yax; Michelsen, Klaus; Eastwood, Heather; Schnier, Paul D; Nixey, Thomas; Zhong, Wenge

2012-01-26

Fragment based drug discovery (FBDD) is a widely used tool for discovering novel therapeutics. NMR is a powerful means for implementing FBDD, and several approaches have been proposed utilizing (1)H-(15)N heteronuclear single quantum coherence (HSQC) as well as one-dimensional (1)H and (19)F NMR to screen compound mixtures against a target of interest. While proton-based NMR methods of fragment screening (FBS) have been well documented and are widely used, the use of (19)F detection in FBS has been only recently introduced (Vulpetti et al. J. Am. Chem. Soc.2009, 131 (36), 12949-12959) with the aim of targeting "fluorophilic" sites in proteins. Here, we demonstrate a more general use of (19)F NMR-based fragment screening in several areas: as a key tool for rapid and sensitive detection of fragment hits, as a method for the rapid development of structure-activity relationship (SAR) on the hit-to-lead path using in-house libraries and/or commercially available compounds, and as a quick and efficient means of assessing target druggability.

Imaging in Central Nervous System Drug Discovery.

PubMed

Gunn, Roger N; Rabiner, Eugenii A

2017-01-01

The discovery and development of central nervous system (CNS) drugs is an extremely challenging process requiring large resources, timelines, and associated costs. The high risk of failure leads to high levels of risk. Over the past couple of decades PET imaging has become a central component of the CNS drug-development process, enabling decision-making in phase I studies, where early discharge of risk provides increased confidence to progress a candidate to more costly later phase testing at the right dose level or alternatively to kill a compound through failure to meet key criteria. The so called "3 pillars" of drug survival, namely; tissue exposure, target engagement, and pharmacologic activity, are particularly well suited for evaluation by PET imaging. This review introduces the process of CNS drug development before considering how PET imaging of the "3 pillars" has advanced to provide valuable tools for decision-making on the critical path of CNS drug development. Finally, we review the advances in PET science of biomarker development and analysis that enable sophisticated drug-development studies in man. Copyright © 2017 Elsevier Inc. All rights reserved.

The NOAA OneStop System: From Well-Curated Metadata to Data Discovery

NASA Astrophysics Data System (ADS)

McQuinn, E.; Jakositz, A.; Caldwell, A.; Delk, Z.; Neufeld, D.; Shapiro, J.; Partee, R.; Milan, A.

2017-12-01

The NOAA OneStop project is a pathfinder in the realm of enabling users to search for, discover, and access NOAA data. As the project continues along its path to maturity, it has become evident that three areas are of utmost importance to its success in the Earth science community: ensuring quality metadata, building a robust and scalable backend architecture, and keeping the user interface simple to use. Why is this the case? Because, simply put, we are dealing with all aspects of a Big Data problem: large volumes of disparate data needing to be quickly and easily processed and retrieved. In this presentation we discuss the three key aspects of OneStop architecture and how development in each area must be done through cross-team collaboration in order to succeed. We cover aspects of the web-based user interface and OneStop API and how metadata curators and software engineers have worked together to continually iterate on an ever-improving data discovery tool meant to be used by a variety of users searching across a broad assortment of data types.

A resurgence in field research is essential to better understand the diversity, ecology, and evolution of microbial eukaryotes.

PubMed

Heger, Thierry J; Edgcomb, Virginia P; Kim, Eunsoo; Lukeš, Julius; Leander, Brian S; Yubuki, Naoji

2014-01-01

The discovery and characterization of protist communities from diverse environments are crucial for understanding the overall evolutionary history of life on earth. However, major questions about the diversity, ecology, and evolutionary history of protists remain unanswered, notably because data obtained from natural protist communities, especially of heterotrophic species, remain limited. In this review, we discuss the challenges associated with "field protistology", defined here as the exploration, characterization, and interpretation of microbial eukaryotic diversity within the context of natural environments or field experiments, and provide suggestions to help fill this important gap in knowledge. We also argue that increased efforts in field studies that combine molecular and microscopical methods offer the most promising path toward (1) the discovery of new lineages that expand the tree of eukaryotes; (2) the recognition of novel evolutionary patterns and processes; (3) the untangling of ecological interactions and functions, and their roles in larger ecosystem processes; and (4) the evaluation of protist adaptations to a changing climate. © 2013 The Author(s) Journal of Eukaryotic Microbiology © 2013 International Society of Protistologists.

Lessons from the Salk Polio Vaccine: Methods for and Risks of Rapid Translation

PubMed Central

Juskewitch, B.A., Justin E.; Tapia, B.A., Carmen J.; Windebank, Anthony J.

2010-01-01

Abstract The Salk inactivated poliovirus vaccine is one of the most rapid examples of bench‐to‐bedside translation in medicine. In the span of 6 years, the key basic lab discoveries facilitating the development of the vaccine were made, optimization and safety testing was completed in both animals and human volunteers, the largest clinical trial in history of 1.8 million children was conducted, and the results were released to an eagerly awaiting public. Such examples of rapid translation cannot only offer clues to what factors can successfully drive and accelerate the translational process but also what mistakes can occur (and thus should be avoided) during such a swift process. In this commentary, we explore the translational path of the Salk polio vaccine from the key basic science discoveries to the 1954 Field Trials and delve into the scientific and sociopolitical factors that aided in its rapid development. Moreover, we look at the Cutter and Wyeth incidents after the vaccine’s approval and the errors that led to them. Clin Trans Sci 2010; Volume 3: 182–185 PMID:20718820

Computational Physics' Greatest Hits

NASA Astrophysics Data System (ADS)

Bug, Amy

2011-03-01

The digital computer, has worked its way so effectively into our profession that now, roughly 65 years after its invention, it is virtually impossible to find a field of experimental or theoretical physics unaided by computational innovation. It is tough to think of another device about which one can make that claim. In the session ``What is computational physics?'' speakers will distinguish computation within the field of computational physics from this ubiquitous importance across all subfields of physics. This talk will recap the invited session ``Great Advances...Past, Present and Future'' in which five dramatic areas of discovery (five of our ``greatest hits'') are chronicled: The physics of many-boson systems via Path Integral Monte Carlo, the thermodynamic behavior of a huge number of diverse systems via Monte Carlo Methods, the discovery of new pharmaceutical agents via molecular dynamics, predictive simulations of global climate change via detailed, cross-disciplinary earth system models, and an understanding of the formation of the first structures in our universe via galaxy formation simulations. The talk will also identify ``greatest hits'' in our field from the teaching and research perspectives of other members of DCOMP, including its Executive Committee.

High-throughput materials discovery and development: breakthroughs and challenges in the mapping of the materials genome

NASA Astrophysics Data System (ADS)

Buongiorno Nardelli, Marco

High-Throughput Quantum-Mechanics computation of materials properties by ab initio methods has become the foundation of an effective approach to materials design, discovery and characterization. This data driven approach to materials science currently presents the most promising path to the development of advanced technological materials that could solve or mitigate important social and economic challenges of the 21st century. In particular, the rapid proliferation of computational data on materials properties presents the possibility to complement and extend materials property databases where the experimental data is lacking and difficult to obtain. Enhanced repositories such as AFLOWLIB open novel opportunities for structure discovery and optimization, including uncovering of unsuspected compounds, metastable structures and correlations between various properties. The practical realization of these opportunities depends almost exclusively on the the design of efficient algorithms for electronic structure simulations of realistic material systems beyond the limitations of the current standard theories. In this talk, I will review recent progress in theoretical and computational tools, and in particular, discuss the development and validation of novel functionals within Density Functional Theory and of local basis representations for effective ab-initio tight-binding schemes. Marco Buongiorno Nardelli is a pioneer in the development of computational platforms for theory/data/applications integration rooted in his profound and extensive expertise in the design of electronic structure codes and in his vision for sustainable and innovative software development for high-performance materials simulations. His research activities range from the design and discovery of novel materials for 21st century applications in renewable energy, environment, nano-electronics and devices, the development of advanced electronic structure theories and high-throughput techniques in materials genomics and computational materials design, to an active role as community scientific software developer (QUANTUM ESPRESSO, WanT, AFLOWpi)

ALISEO on MIOSat: an imaging interferometer for earth observation

NASA Astrophysics Data System (ADS)

Barducci, A.; Castagnoli, F.; Castellini, G.; Guzzi, D.; Marcoionni, P.; Pippi, I.

2017-11-01

The Italian Space Agency (ASI) decided to perform an low cost Earth observation mission based on a new mini satellite named MIOsat which will carry various technological payloads. Among them an imaging interferometer designed and now ready to be assembled and tested by our Institute. The instrument, named ALISEO (Aerospace Leap-frog Imaging Stationary interferometer for Earth Observation), operates in the common-path Sagnac configuration, and it does not utilize any moving part to scan the phase delays between the two interfering beams. The sensor acquires target images modulated by a pattern of autocorrelation functions of the energy coming from each scene pixel, and the resulting fringe pattern remains spatially fixed with respect to the instrument's field-of-view. The complete interferogram of each target location is retrieved by introducing a relative source-observer motion, which allows any image pixels to be observed under different viewing-angles and experience discrete path differences. The paper describes the main characteristics of the imaging interferometer as well as the overall optical configuration and the electronics layout. Moreover some theoretical issues concerning sampling theory in "common path" imaging interferometry are investigated. The experimental activity performed in laboratory is presented and its outcomes are analysed. Particularly, a set of measurements has been carried out using both standard (certificate) reflectance tiles and natural samples of different volcanic rocks. An algorithm for raw data pre-processing aimed at retrieving the at-sensor radiance spectrum is introduced and its performance is addressed by taking into account various issues such as dark signal subtraction, spectral instrument response compensation, effects of vignetting, and Fourier backtransform. Finally, examples of retrieved absolute reflectance of several samples are sketched at different wavelengths.

Continuous in-situ methane measurements at paddy fields in a rural area of India with poor electric infrastructure, using a low-cost instrument based on open-path near-IR laser absorption spectroscopy

NASA Astrophysics Data System (ADS)

Hidemori, T.; Matsumi, Y.; Nakayama, T.; Kawasaki, M.; Sasago, H.; Takahashi, K.; Imasu, R.; Takeuchi, W.; Adachi, M.; Machida, T.; Terao, Y.; Nomura, S.; Dhaka, S. K.; Singh, J.

2015-12-01

In southeast and south Asia, the previous satellite observations suggest that the methane emission from rice paddies is significant and important source of methane during rainy season. Since it is difficult to measure methane stably and continuously at rural areas such as the paddy fields in terms of infrastructures and maintenances, there are large uncertainties in quantitative estimation of methane emission in these areas and there are needs for more certification between satellite and ground based measurements. To measure methane concentrations continuously at difficult situations such as the center of paddy fields　and wetlands, we developed the continuous in-situ measurement system, not to look for your lost keys under the streetlight. The methane gas sensor is used an open-path laser based measurement instrument (LaserMethane, ANRITSU CORPORATION), which can quickly and selectively detect average methane concentrations on the optical path of the laser beam. The developed system has the power supply and telecommunication system to run the laser gas sensor in rural areas with poor electricity infrastructure.The methane measurement system was installed at paddy fields of Sonepat, Haryana on the north of Delhi in India and has been operated from the end of 2014. The air sampling along with our measurement has been carried out once a week during daytime to calibrate the laser instrument. We found that the seasonal variation of methane concentrations was different from the satellite observations and there were significant diurnal variations, which it was difficult to detect from occasional air samplings. We will present details of the measurement system and recent results of continuous methane measurements in India.

Energy Savings Modeling and Inspection Guidelines for Commercial Building Federal Tax Deductions for Buildings in 2016 and Later

DOE Office of Scientific and Technical Information (OSTI.GOV)

Deru, Michael; Field-Macumber, Kristin

This document provides guidance for modeling and inspecting energy-efficient property in commercial buildings for certification of the energy and power cost savings related to Section 179D of the Internal Revenue Code (IRC) enacted in Section 1331 of the 2005 Energy Policy Act (EPAct) of 2005, noted in Internal Revenue Service (IRS) Notices 2006-52 (IRS 2006), 2008-40 (IRS 2008) and 2012-26 (IRS 2012), and updated by the Protecting Americans from Tax Hikes (PATH) Act of 2015. Specifically, Section 179D provides federal tax deductions for energy-efficient property related to a commercial building's envelope; interior lighting; heating, ventilating, and air conditioning (HVAC); andmore » service hot water (SHW) systems. This document applies to buildings placed in service on or after January 1, 2016.« less

The fastclime Package for Linear Programming and Large-Scale Precision Matrix Estimation in R.

PubMed

Pang, Haotian; Liu, Han; Vanderbei, Robert

2014-02-01

We develop an R package fastclime for solving a family of regularized linear programming (LP) problems. Our package efficiently implements the parametric simplex algorithm, which provides a scalable and sophisticated tool for solving large-scale linear programs. As an illustrative example, one use of our LP solver is to implement an important sparse precision matrix estimation method called CLIME (Constrained L 1 Minimization Estimator). Compared with existing packages for this problem such as clime and flare, our package has three advantages: (1) it efficiently calculates the full piecewise-linear regularization path; (2) it provides an accurate dual certificate as stopping criterion; (3) it is completely coded in C and is highly portable. This package is designed to be useful to statisticians and machine learning researchers for solving a wide range of problems.

Citizen science can improve conservation science, natural resource management, and environmental protection

USGS Publications Warehouse

McKinley, Duncan C.; Miller-Rushing, Abe J.; Ballard, Heidi L.; Bonney, Rick; Brown, Hutch; Cook-Patton, Susan; Evans, Daniel M.; French, Rebecca A.; Parrish, Julia; Phillips, Tina B.; Ryan, Sean F.; Shanley, Lea A.; Shirk, Jennifer L.; Stepenuck, Kristine F.; Weltzin, Jake F.; Wiggins, Andrea; Boyle, Owen D.; Briggs, Russell D.; Chapin, Stuart F.; Hewitt, David A.; Preuss, Peter W.; Soukup, Michael A.

2017-01-01

Citizen science has advanced science for hundreds of years, contributed to many peer-reviewed articles, and informed land management decisions and policies across the United States. Over the last 10 years, citizen science has grown immensely in the United States and many other countries. Here, we show how citizen science is a powerful tool for tackling many of the challenges faced in the field of conservation biology. We describe the two interwoven paths by which citizen science can improve conservation efforts, natural resource management, and environmental protection. The first path includes building scientific knowledge, while the other path involves informing policy and encouraging public action. We explore how citizen science is currently used and describe the investments needed to create a citizen science program. We find that:Citizen science already contributes substantially to many domains of science, including conservation, natural resource, and environmental science. Citizen science informs natural resource management, environmental protection, and policymaking and fosters public input and engagement.Many types of projects can benefit from citizen science, but one must be careful to match the needs for science and public involvement with the right type of citizen science project and the right method of public participation.Citizen science is a rigorous process of scientific discovery, indistinguishable from conventional science apart from the participation of volunteers. When properly designed, carried out, and evaluated, citizen science can provide sound science, efficiently generate high-quality data, and help solve problems.

Interactive analysis of geographically distributed population imaging data collections over light-path data networks

NASA Astrophysics Data System (ADS)

van Lew, Baldur; Botha, Charl P.; Milles, Julien R.; Vrooman, Henri A.; van de Giessen, Martijn; Lelieveldt, Boudewijn P. F.

2015-03-01

The cohort size required in epidemiological imaging genetics studies often mandates the pooling of data from multiple hospitals. Patient data, however, is subject to strict privacy protection regimes, and physical data storage may be legally restricted to a hospital network. To enable biomarker discovery, fast data access and interactive data exploration must be combined with high-performance computing resources, while respecting privacy regulations. We present a system using fast and inherently secure light-paths to access distributed data, thereby obviating the need for a central data repository. A secure private cloud computing framework facilitates interactive, computationally intensive exploration of this geographically distributed, privacy sensitive data. As a proof of concept, MRI brain imaging data hosted at two remote sites were processed in response to a user command at a third site. The system was able to automatically start virtual machines, run a selected processing pipeline and write results to a user accessible database, while keeping data locally stored in the hospitals. Individual tasks took approximately 50% longer compared to a locally hosted blade server but the cloud infrastructure reduced the total elapsed time by a factor of 40 using 70 virtual machines in the cloud. We demonstrated that the combination light-path and private cloud is a viable means of building an analysis infrastructure for secure data analysis. The system requires further work in the areas of error handling, load balancing and secure support of multiple users.

NEOview: Near Earth Object Data Discovery and Query

NASA Astrophysics Data System (ADS)

Tibbetts, M.; Elvis, M.; Galache, J. L.; Harbo, P.; McDowell, J. C.; Rudenko, M.; Van Stone, D.; Zografou, P.

2013-10-01

Missions to Near Earth Objects (NEOs) figure prominently in NASA's Flexible Path approach to human space exploration. NEOs offer insight into both the origins of the Solar System and of life, as well as a source of materials for future missions. With NEOview scientists can locate NEO datasets, explore metadata provided by the archives, and query or combine disparate NEO datasets in the search for NEO candidates for exploration. NEOview is a software system that illustrates how standards-based interfaces facilitate NEO data discovery and research. NEOview software follows a client-server architecture. The server is a configurable implementation of the International Virtual Observatory Alliance (IVOA) Table Access Protocol (TAP), a general interface for tabular data access, that can be deployed as a front end to existing NEO datasets. The TAP client, seleste, is a graphical interface that provides intuitive means of discovering NEO providers, exploring dataset metadata to identify fields of interest, and constructing queries to retrieve or combine data. It features a powerful, graphical query builder capable of easing the user's introduction to table searches. Through science use cases, NEOview demonstrates how potential targets for NEO rendezvous could be identified by combining data from complementary sources. Through deployment and operations, it has been shown that the software components are data independent and configurable to many different data servers. As such, NEOview's TAP server and seleste TAP client can be used to create a seamless environment for data discovery and exploration for tabular data in any astronomical archive.

Axial compressor gas path design for desensitization of aerodynamic performance and stability to tip clearance

NASA Astrophysics Data System (ADS)

Cevik, Mert

Tip clearance is the necessary small gap left between the moving rotor tip and stationary shroud of a turbomachine. In a compressor, the pressure driven flow through this gap, called tip clearance flow, has a major and generally detrimental impact on compressor performance (pressure ratio and efficiency) and aerodynamic stability (stall margin). The increase in tip clearance, either temporary during transient engine operations or permanent from wear, leads to a drop in compressor performance and aerodynamic stability which results in a fuel consumption increase and a reduced operating envelope for a gas turbine engine. While much research has looked into increasing compressor performance and stall margin at the design (minimum or nominal) tip clearance, very little attention has been paid for reducing the sensitivity of these parameters to tip clearance size increase. The development of technologies that address this issue will lead to aircraft engines whose performance and operating envelope are more robust to operational demands and wear. The current research is the second phase of a research programme to develop design strategies to reduce the sensitivity of axial compressor performance and aerodynamic stability to tip clearance. The first phase had focused on blade design strategies and had led to the discovery and explanation of two flow features that reduces tip sensitivity, namely increased incoming meridional momentum in the rotor tip region and reduction/elimination of double leakage. Double leakage is the flow that exits one tip clearance and enters the tip clearance of the adjacent blade instead of convecting downstream out of the rotor passage. This flow was shown to be very detrimental to compressor performance and stall margin. Two rotor design strategies involving sweep and tip stagger reduction were proposed and shown by CFD simulations to exploit these features to reduce sensitivity. As the second phase, the objectives of the current research project are to develop gas path design strategies for axial compressors to achieve the same goal, to assess their ability to be combined with desensitizing axial compressor blade design strategies and to be applied to non-axial compressors. The search for gas path design strategies was based on the exploitation of the two flow desensitizing features listed above. Two gas path design strategies were proposed and analyzed. The first was gas path contouring in the form of a concave gas path to increase incoming tip meridional momentum.

Discovery of novel EGFR tyrosine kinase inhibitors by structure-based virtual screening.

PubMed

Li, Siyuan; Sun, Xianqiang; Zhao, Hongli; Tang, Yun; Lan, Minbo

2012-06-15

By using of structure-based virtual screening, 13 novel epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors were discovered from 197,116 compounds in the SPECS database here. Among them, 8 compounds significantly inhibited EGFR kinase activity with IC(50) values lower than 10 μM. 3-{[1-(3-Chloro-4-fluorophenyl)-3,5-dioxo-4-pyrazolidinylidene]methyl}phenyl 2-thiophenecarboxylate (13), particularly, was the most potent inhibitor possessing the IC(50) value of 3.5 μM. The docking studies also provide some useful information that the docking models of the 13 compounds are beneficial to find a new path for designing novel EGFR inhibitors. Copyright © 2012 Elsevier Ltd. All rights reserved.

Two Basic Scientists Walk into a Translational Space.

PubMed

2017-09-21

When John Schiller first joined Douglas Lowy's lab at the National Cancer Institute of the NIH, he could have not predicted that their common interest in the molecular biology of oncogenes would set them in path for discoveries that ultimately enabled the development of a vaccine for the human papillomavirus, which causes the majority of cervical cancers worldwide. John and Doug, the recipients of the 2017 Lasker-DeBakey Clinical Award, have joined Cell editor João Monteiro in a Conversation about science, public health, and the joys and challenges of being basic scientists in a translational space. Annotated excerpts from this conversation are presented below. Copyright © 2017. Published by Elsevier Inc.

Qualitative and quantitative mass spectrometry imaging of drugs and metabolites.

PubMed

Lietz, Christopher B; Gemperline, Erin; Li, Lingjun

2013-07-01

Mass spectrometric imaging (MSI) has rapidly increased its presence in the pharmaceutical sciences. While quantitative whole-body autoradiography and microautoradiography are the traditional techniques for molecular imaging of drug delivery and metabolism, MSI provides advantageous specificity that can distinguish the parent drug from metabolites and modified endogenous molecules. This review begins with the fundamentals of MSI sample preparation/ionization, and then moves on to both qualitative and quantitative applications with special emphasis on drug discovery and delivery. Cutting-edge investigations on sub-cellular imaging and endogenous signaling peptides are also highlighted, followed by perspectives on emerging technology and the path for MSI to become a routine analysis technique. Copyright © 2013 Elsevier B.V. All rights reserved.

Qualitative and quantitative mass spectrometry imaging of drugs and metabolites

PubMed Central

Lietz, Christopher B.; Gemperline, Erin; Li, Lingjun

2013-01-01

Mass spectrometric imaging (MSI) has rapidly increased its presence in the pharmaceutical sciences. While quantitative whole-body autoradiography and microautoradiography are the traditional techniques for molecular imaging of drug delivery and metabolism, MSI provides advantageous specificity that can distinguish the parent drug from metabolites and modified endogenous molecules. This review begins with the fundamentals of MSI sample preparation/ionization, and then moves on to both qualitative and quantitative applications with special emphasis on drug discovery and delivery. Cutting-edge investigations on sub-cellular imaging and endogenous signaling peptides are also highlighted, followed by perspectives on emerging technology and the path for MSI to become a routine analysis technique. PMID:23603211

Drug discovery in the next decade: innovation needed ASAP.

PubMed

Bennani, Youssef L

2011-09-01

Pharmaceutical companies must find a better way to increase their output of truly new drugs for the benefit of patients and for their business survival. Here, I highlight a general perspective from within pharmaceutical research as it pertains to research advances in chemistry, biology, pharmacology, pharmacokinetics and toxicology that, if well integrated, stands to put the industry on a productive path. In addition, I provide a complementary perspective on the corporate culture aspect of innovation. I also introduce a new concept, termed 'innovation ASAP' (iASAP; asking powerful questions, seeking the outliers, accepting defeat and populating astutely) and provide support for it using examples of several successful drugs. Copyright © 2011 Elsevier Ltd. All rights reserved.

Biopharma business models in Canada.

PubMed

March-Chordà, I; Yagüe-Perales, R M

2011-08-01

This article provides new insights into the different strategy paths or business models currently being implemented by Canadian biopharma companies. Through a case-study methodology, seven biopharma companies pertaining to three business models were analyzed, leading to a broad set of results emerging from the following areas: activity, business model and strategy; management and human resources; and R&D, technology and innovation strategy. The three business models represented were: model 1 (conventional biotech oriented to new drug development, radical innovation and search for discoveries); model 2 (development of a technology platform, usually in proteomics and bioinformatics); and model 3 (incremental innovation, with shorter and less risky development timelines). Copyright © 2011 Elsevier Ltd. All rights reserved.

Genetics and biology of pancreatic ductal adenocarcinoma

PubMed Central

Ying, Haoqiang; Dey, Prasenjit; Yao, Wantong; Kimmelman, Alec C.; Draetta, Giulio F.; Maitra, Anirban; DePinho, Ronald A.

2016-01-01

With 5-year survival rates remaining constant at 6% and rising incidences associated with an epidemic in obesity and metabolic syndrome, pancreatic ductal adenocarcinoma (PDAC) is on track to become the second most common cause of cancer-related deaths by 2030. The high mortality rate of PDAC stems primarily from the lack of early diagnosis and ineffective treatment for advanced tumors. During the past decade, the comprehensive atlas of genomic alterations, the prominence of specific pathways, the preclinical validation of such emerging targets, sophisticated preclinical model systems, and the molecular classification of PDAC into specific disease subtypes have all converged to illuminate drug discovery programs with clearer clinical path hypotheses. A deeper understanding of cancer cell biology, particularly altered cancer cell metabolism and impaired DNA repair processes, is providing novel therapeutic strategies that show strong preclinical activity. Elucidation of tumor biology principles, most notably a deeper understanding of the complexity of immune regulation in the tumor microenvironment, has provided an exciting framework to reawaken the immune system to attack PDAC cancer cells. While the long road of translation lies ahead, the path to meaningful clinical progress has never been clearer to improve PDAC patient survival. PMID:26883357

First Results from Contamination Monitoring with the WFC3 UVIS G280 Grism

NASA Astrophysics Data System (ADS)

Rothberg, B.; Pirzkal, N.; Baggett, S.

2011-11-01

The presence of contaminants within the optical light path of the instrument or telescope can alter photometric zeropoints and the observed flux levels of imaging and spectra, particularly at UV wavelengths. Regular monitoring of a spectro-photometric standard star using photometric filters has been used in the past to monitor the presence of contaminants and (when necessary) re-calibrate zeropoints. However, the use of the WFC3 UVIS Grism mode (G280 filter) may provide a more robust early alert detection system for the presence of contaminants, in particular, those that are photo-polymerized from the bright Earth. These contaminants may collect on surfaces in the optical light path of the telescope. The G280 grism is sensitive to light at wavelengths below the cutoff of the bluest UV filter (F218W). In this ISR, we present: 1) the first results from G280 monitoring for the period of 2010-November through 2011-August; 2) the discovery of an anomaly in the WCS header information of sub-array exposures; and 3) an outline for reducing standard G280 grism observations and the specialized case of observations obtained in sub-array mode.

Mistletoe Berry Outline Mapping with a Path Curve Function and Recording the Circadian Rhythm of Their Phenotypic Shape Change

PubMed Central

Derbidge, Renatus; Baumgartner, Stephan; Heusser, Peter

2016-01-01

This paper presents a discovery: the change of the outline shape of mistletoe (Viscum album ssp. album) berries in vivo and in situ during ripening. It was found that a plant organ that is usually considered to merely increase in size actually changes shape in a specific rhythmic fashion. We introduce a new approach to chronobiological research on a macro-phenotypic scale to trace changes over long periods of time (with a resolution from hours to months) by using a dynamic form-determining parameter called Lambda (λ). λ is known in projective geometry as a measure for pertinent features of the outline shapes of egg-like forms, so called path curves. Ascertained circadian changes of form were analyzed for their correlation with environmental factors such as light, temperature, and other weather influences. Certain weather conditions such as sky cover, i.e., sunshine minutes per hour, have an impact on the amplitude of the daily change in form. The present paper suggests a possible supplement to established methods in chronobiology, as in this case the dynamic of form-change becomes a measurable feature, displaying a convincing accordance between mathematical rule and plant shape. PMID:27933073

9977 TYPE B PACKAGING INTERNAL DATA COLLECTION FEASIBILITY TESTING - MAGNETIC FIELD COMMUNICATIONS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shull, D.

2012-06-18

The objective of this report is to document the findings from proof-of-concept testing performed by the Savannah River National Laboratory (SRNL) R&D Engineering and Visible Assets, Inc. for the DOE Packaging Certification Program (PCP) to determine if RuBee (IEEE 1902.1) tags and readers could be used to provide a communication link from within a drum-style DOE certified Type B radioactive materials packaging. A Model 9977 Type B Packaging was used to test the read/write capability and range performance of a RuBee tag and reader. Testing was performed with the RuBee tags placed in various locations inside the packaging including insidemore » the drum on the outside of the lid of the containment vessel and also inside of the containment vessel. This report documents the test methods and results. A path forward will also be recommended.« less

Chile's National Center for Health Information Systems: A Public-Private Partnership to Foster Health Care Information Interoperability.

PubMed

Capurro, Daniel; Echeverry, Aisen; Figueroa, Rosa; Guiñez, Sergio; Taramasco, Carla; Galindo, César; Avendaño, Angélica; García, Alejandra; Härtel, Steffen

2017-01-01

Despite the continuous technical advancements around health information standards, a critical component to their widespread adoption involves political agreement between a diverse set of stakeholders. Countries that have addressed this issue have used diverse strategies. In this vision paper we present the path that Chile is taking to establish a national program to implement health information standards and achieve interoperability. The Chilean government established an inter-agency program to define the current interoperability situation, existing gaps, barriers, and facilitators for interoperable health information systems. As an answer to the identified issues, the government decided to fund a consortium of Chilean universities to create the National Center for Health Information Systems. This consortium should encourage the interaction between all health care stakeholders, both public and private, to advance the selection of national standards and define certification procedures for software and human resources in health information technologies.

9978 AND 9975 TYPE B PACKAGING INTERNAL DATA COLLECTION FEASIBILITY TESTING

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fogle, R.

The objective of this report is to document the findings from a series of proof-of-concept tests performed by Savannah River National Laboratory (SRNL) R and D Engineering, for the DOE Packaging Certification Program to determine if a viable radio link could be established from within the stainless steel confines of several drum-style DOE certified Type B radioactive materials packagings. Two in-hand, off-the-shelf radio systems were tested. The first system was a Wi-Fi Librestream Onsight{trademark} camera with a Fortress ES820 Access Point and the second was the On-Ramp Wireless Ultra-Link Processing{trademark} (ULP) radio system. These radio systems were tested within themore » Model 9975 and 9978 Type B packagings at the SRNL. This report documents the test methods and results. A path forward will also be recommended.« less

42 CFR 493.43 - Application for registration certificate, certificate for provider-performed microscopy (PPM...

Code of Federal Regulations, 2013 CFR

2013-10-01

..., certificate for provider-performed microscopy (PPM) procedures, and certificate of compliance. 493.43 Section... Provider-performed Microscopy Procedures, and Certificate of Compliance § 493.43 Application for registration certificate, certificate for provider-performed microscopy (PPM) procedures, and certificate of...

42 CFR 493.43 - Application for registration certificate, certificate for provider-performed microscopy (PPM...

Code of Federal Regulations, 2010 CFR

2010-10-01

..., certificate for provider-performed microscopy (PPM) procedures, and certificate of compliance. 493.43 Section... Provider-performed Microscopy Procedures, and Certificate of Compliance § 493.43 Application for registration certificate, certificate for provider-performed microscopy (PPM) procedures, and certificate of...

42 CFR 493.43 - Application for registration certificate, certificate for provider-performed microscopy (PPM...

Code of Federal Regulations, 2012 CFR

2012-10-01

..., certificate for provider-performed microscopy (PPM) procedures, and certificate of compliance. 493.43 Section... Provider-performed Microscopy Procedures, and Certificate of Compliance § 493.43 Application for registration certificate, certificate for provider-performed microscopy (PPM) procedures, and certificate of...

42 CFR 493.43 - Application for registration certificate, certificate for provider-performed microscopy (PPM...

Code of Federal Regulations, 2011 CFR

2011-10-01

..., certificate for provider-performed microscopy (PPM) procedures, and certificate of compliance. 493.43 Section... Provider-performed Microscopy Procedures, and Certificate of Compliance § 493.43 Application for registration certificate, certificate for provider-performed microscopy (PPM) procedures, and certificate of...

42 CFR 493.43 - Application for registration certificate, certificate for provider-performed microscopy (PPM...

Code of Federal Regulations, 2014 CFR

2014-10-01

..., certificate for provider-performed microscopy (PPM) procedures, and certificate of compliance. 493.43 Section... Provider-performed Microscopy Procedures, and Certificate of Compliance § 493.43 Application for registration certificate, certificate for provider-performed microscopy (PPM) procedures, and certificate of...

Religion and reality: the three doubts of Hillel.

PubMed

Nicholis, W; Kent, I

1975-01-01

The authors present an existential approach to the understanding of reality through an analysis of doubt. Doubt is understood as a healthy questioning of what others take for real, a search for that which will stand up to all criticism. Doubt begins in childhood, when one questions the authenticity of his parent's relationship to him. This doubt evokes anger, which normally leads to rebellion against or identification with the parents. Neither choice leads to personal authenticity or reality. Only the discovery of the true Self can heal this pain. There is a third choice possible, however, which takes account of another aspect of doubt, the one who doubts. When I doubt, I know that I don't know. Doubt then leads to the existential question, Who am I? This doubt is really faith, leading to Self-discovery. On the basis of this analysis, we re-open the old question of religion and reality. In predominantly religious cultures, the existential question, Who am I? has given rise to practical philosophies such as Yoga and Zen, together with their Western counterparts, the mysticisms associated with Judaism, Christianity and Islam. The same analysis of existential doubt as a path to the Self is to be found in Hillel's three questions.

Concise Review: Progress and Challenges in Using Human Stem Cells for Biological and Therapeutics Discovery: Neuropsychiatric Disorders.

PubMed

Panchision, David M

2016-03-01

In facing the daunting challenge of using human embryonic and induced pluripotent stem cells to study complex neural circuit disorders such as schizophrenia, mood and anxiety disorders, and autism spectrum disorders, a 2012 National Institute of Mental Health workshop produced a set of recommendations to advance basic research and engage industry in cell-based studies of neuropsychiatric disorders. This review describes progress in meeting these recommendations, including the development of novel tools, strides in recapitulating relevant cell and tissue types, insights into the genetic basis of these disorders that permit integration of risk-associated gene regulatory networks with cell/circuit phenotypes, and promising findings of patient-control differences using cell-based assays. However, numerous challenges are still being addressed, requiring further technological development, approaches to resolve disease heterogeneity, and collaborative structures for investigators of different disciplines. Additionally, since data obtained so far is on small sample sizes, replication in larger sample sets is needed. A number of individual success stories point to a path forward in developing assays to translate discovery science to therapeutics development. Published 2016. This article is a U.S. Government work and is in the public domain in the USA.

Bridging the gap

PubMed Central

Mahler, Stephen M; Huang, Edwin P; Chin, David Y; Gray, Peter P

2011-01-01

Therapeutic monoclonal antibodies (mAbs) currently dominate the biologics marketplace. Development of a new therapeutic mAb candidate is a complex, multistep process and early stages of development typically begin in an academic research environment. Recently, a number of facilities and initiatives have been launched to aid researchers along this difficult path and facilitate progression of the next mAb blockbuster. Complementing this, there has been a renewed interest from the pharmaceutical industry to reconnect with academia in order to boost dwindling pipelines and encourage innovation. In this review, we examine the steps required to take a therapeutic mAb from discovery through early stage preclinical development and toward becoming a feasible clinical candidate. Discussion of the technologies used for mAb discovery, production in mammalian cells and innovations in single-use bioprocessing is included. We also examine regulatory requirements for product quality and characterization that should be considered at the earliest stages of mAb development. We provide details on the facilities available to help researchers and small-biotech build value into early stage product development, and include examples from within our own facility of how technologies are utilized and an analysis of our client base. PMID:21822050

[Cardiology was born with the modern medical science].

PubMed

de Micheli, Alfredo

2015-01-01

Modern medical science was born in the post-Renaissance age and began to consolidate towards the middle of the XVII century thanks to physicists, physiologists and biologists, most of whom were direct or indirect pupils of Galileo. The discovery of blood circulation by Harvey is now considered the only progress in physiology at the beginning of the XVII century, comparable to the current advances seen in physical sciences. The history of this exploit could be written from view point of the progressive advance in knowledge. In his experiments, Harvey referred to the authentic not imaginary experiments, and put forward irrefutable quantitative arguments. We can therefore claim that his discovery of blood circulation was the first proper explanation of an organic process and the starting point leading to experimental physiology. So it seems justified to assert that modern medical science did not all rise suddenly, but was gradually structured starting from the middle of the XVII century following the path traced by William Harvey in light of Galileo's thought. Copyright © 2014 Instituto Nacional de Cardiología Ignacio Chávez. Published by Masson Doyma México S.A. All rights reserved.

Barriers to the Preclinical Development of Therapeutics that Target Aging Mechanisms

PubMed Central

Burd, Christin E.; Gill, Matthew S.; Niedernhofer, Laura J.; Robbins, Paul D.; Austad, Steven N.; Barzilai, Nir

2016-01-01

Through the progress of basic science research, fundamental mechanisms that contribute to age-related decline are being described with increasing depth and detail. Although these efforts have identified new drug targets and compounds that extend life span in model organisms, clinical trials of therapeutics that target aging processes remain scarce. Progress in aging research is hindered by barriers associated with the translation of basic science discoveries into the clinic. This report summarizes discussions held at a 2014 Geroscience Network retreat focused on identifying hurdles that currently impede the preclinical development of drugs targeting fundamental aging processes. From these discussions, it was evident that aging researchers have varied perceptions of the ideal preclinical pipeline. To forge a clear and cohesive path forward, several areas of controversy must first be resolved and new tools developed. Here, we focus on five key issues in preclinical drug development (drug discovery, lead compound development, translational preclinical biomarkers, funding, and integration between researchers and clinicians), expanding upon discussions held at the Geroscience Retreat and suggesting areas for further research. By bringing these findings to the attention of the aging research community, we hope to lay the foundation for a concerted preclinical drug development pipeline. PMID:27535964

Heterogeniety and Heterarchy: How far can network analyses in Earth and space sciences?

NASA Astrophysics Data System (ADS)

Prabhu, A.; Fox, P. A.; Eleish, A.; Li, C.; Pan, F.; Zhong, H.

2017-12-01

The vast majority of explorations of Earth systems are limited in their ability to effectively explore the most important (often most difficult) problems because they are forced to interconnect at the data-element, or syntactic, level rather than at a higher scientific, or conceptual/ semantic, level. Recent successes in the application of complex network theory and algorithms to minerology, fossils and proteins over billions of years of Earth's history, raise expectations that more general graph-based approaches offer the opportunity for new discoveries = needles instead of haystacks. In the past 10 years in the natural sciences there has substantial progress in providing both specialists and non-specialists the ability to describe in machine readable form, geophysical quantities and relations among them in meaningful and natural ways, effectively breaking the prior syntax barrier. The corresponding open-world semantics and reasoning provide higher-level interconnections. That is, semantics provided around the data structures, using open-source tools, allow for discovery at the knowledge level. This presentation will cover the fundamentals of data-rich network analyses for geosciences, provide illustrative examples in mineral evolution and offer future paths for consideration.

Bridging the gap: facilities and technologies for development of early stage therapeutic mAb candidates.

PubMed

Munro, Trent P; Mahler, Stephen M; Huang, Edwin P; Chin, David Y; Gray, Peter P

2011-01-01

Therapeutic monoclonal antibodies (mAbs) currently dominate the biologics marketplace. Development of a new therapeutic mAb candidate is a complex, multistep process and early stages of development typically begin in an academic research environment. Recently, a number of facilities and initiatives have been launched to aid researchers along this difficult path and facilitate progression of the next mAb blockbuster. Complementing this, there has been a renewed interest from the pharmaceutical industry to reconnect with academia in order to boost dwindling pipelines and encourage innovation. In this review, we examine the steps required to take a therapeutic mAb from discovery through early stage preclinical development and toward becoming a feasible clinical candidate. Discussion of the technologies used for mAb discovery, production in mammalian cells and innovations in single-use bioprocessing is included. We also examine regulatory requirements for product quality and characterization that should be considered at the earliest stages of mAb development. We provide details on the facilities available to help researchers and small-biotech build value into early stage product development, and include examples from within our own facility of how technologies are utilized and an analysis of our client base.

An interactive visualization tool for mobile objects

NASA Astrophysics Data System (ADS)

Kobayashi, Tetsuo

Recent advancements in mobile devices---such as Global Positioning System (GPS), cellular phones, car navigation system, and radio-frequency identification (RFID)---have greatly influenced the nature and volume of data about individual-based movement in space and time. Due to the prevalence of mobile devices, vast amounts of mobile objects data are being produced and stored in databases, overwhelming the capacity of traditional spatial analytical methods. There is a growing need for discovering unexpected patterns, trends, and relationships that are hidden in the massive mobile objects data. Geographic visualization (GVis) and knowledge discovery in databases (KDD) are two major research fields that are associated with knowledge discovery and construction. Their major research challenges are the integration of GVis and KDD, enhancing the ability to handle large volume mobile objects data, and high interactivity between the computer and users of GVis and KDD tools. This dissertation proposes a visualization toolkit to enable highly interactive visual data exploration for mobile objects datasets. Vector algebraic representation and online analytical processing (OLAP) are utilized for managing and querying the mobile object data to accomplish high interactivity of the visualization tool. In addition, reconstructing trajectories at user-defined levels of temporal granularity with time aggregation methods allows exploration of the individual objects at different levels of movement generality. At a given level of generality, individual paths can be combined into synthetic summary paths based on three similarity measures, namely, locational similarity, directional similarity, and geometric similarity functions. A visualization toolkit based on the space-time cube concept exploits these functionalities to create a user-interactive environment for exploring mobile objects data. Furthermore, the characteristics of visualized trajectories are exported to be utilized for data mining, which leads to the integration of GVis and KDD. Case studies using three movement datasets (personal travel data survey in Lexington, Kentucky, wild chicken movement data in Thailand, and self-tracking data in Utah) demonstrate the potential of the system to extract meaningful patterns from the otherwise difficult to comprehend collections of space-time trajectories.

Rod Photopigment Kinetics After Photodisruption of the Retinal Pigment Epithelium

PubMed Central

Masella, Benjamin D.; Hunter, Jennifer J.; Williams, David R.

2014-01-01

Purpose. Advances in retinal imaging have led to the discovery of long-lasting retinal changes caused by light exposures below published safety limits, including disruption of the RPE. To investigate the functional consequences of RPE disruption, we combined adaptive optics ophthalmoscopy with retinal densitometry. Methods. A modified adaptive optics scanning light ophthalmoscope (AOSLO) measured the apparent density and regeneration rate of rhodopsin in two macaques before and after four different 568-nm retinal radiant exposures (RREs; 400–3200 J/cm2). Optical coherence tomography (OCT) was used to measure the optical path length through the photoreceptor outer segments before and after RPE disruption. Results. All tested RREs caused visible RPE disruption. Apparent rhodopsin density was significantly reduced following 1600 (P = 0.01) and 3200 J/cm2 (P = 0.007) exposures. No significant change in apparent density was observed in response to 800 J/cm2. Surprisingly, exposure to 400 J/cm2 showed a significant increase in apparent density (P = 0.047). Rhodopsin recovery rate was not significantly affected by these RREs. Optical coherence tomography measurements showed a significant decrease in the optical path length through the photoreceptor outer segments for RREs above 800 J/cm2 (P < 0.001). Conclusions. At higher RREs, optical path length through the outer segments was reduced. However, the rate of photopigment regeneration was unchanged. While some ambiguity remains as to the correlation between measured reflectivity and absolute rhodopsin density; at the lowest RREs, RPE disruption appears not to be accompanied by a loss of apparent rhodopsin density, which would have been indicative of functional loss. PMID:25316724

Public-private partnerships as driving forces in the quest for innovative medicines

PubMed Central

2013-01-01

Background Despite progress in translational research, we are still falling short in developing the innovative medicines required to address major public health needs. Furthermore, the failure rate, time, and cost required for registration of a new drug are pushing the economics of the industry to the breaking point. New models of drug development based on collaborative endeavours are badly needed to improve this dire situation. Findings In 2004, the US Food and Drug Administration (FDA) introduced the Critical Path Initiative with the intent of modernizing drug development by implementing public-private partnerships (PPP) to share data, expertise, and resources. In response to FDA’s initiative, in the following year the non-profit Critical Path Institute (C-Path) was formed. At the same time, the National Institutes of Health (NIH) Public-Private Partnership program was established. In Europe, the Innovative Medicines Initiative (IMI) supported jointly by the European Union and the European Federation of Pharmaceutical Industries and Associations was launched in 2008. These independent efforts have a common long-term objective, namely to facilitate the emergence of innovative medicines by developing new tools for drug discovery, new indicators for drug efficacy or safety, and new approaches for patient stratification. Herein, we present evidence that PPP already exert a positive impact on the drug development process. Conclusions Public-private partnerships represent attractive means to leverage resources dispersed across industry, academia, and voluntary health organizations in order to address multiple challenges of drug development in an era of constrained resources and increased regulatory pressure. PMID:23369569

40 CFR 745.90 - Renovator certification and dust sampling technician certification.

Code of Federal Regulations, 2010 CFR

2010-07-01

... sampling technician certification. 745.90 Section 745.90 Protection of Environment ENVIRONMENTAL PROTECTION... RESIDENTIAL STRUCTURES Residential Property Renovation § 745.90 Renovator certification and dust sampling technician certification. (a) Renovator certification and dust sampling technician certification. (1) To...

Certificates in General Education for Adults. Certificate I (Foundation). Certificate II & Certificate II (Further Study).

ERIC Educational Resources Information Center

National Languages and Literacy Inst. of Australia, Melbourne. Adult Education Resource and Information Service.

This document is intended for adult education providers in Victoria, Australia, who intend to deliver courses leading to one or more of the following certificates in general education for adults: Certificate I in General Education for Adults (Foundation); Certificate II in General Education for Adults; and Certificate II in General Education for…

Discovery of estrogen receptor α modulators from natural compounds in Si-Wu-Tang series decoctions using estrogen-responsive MCF-7 breast cancer cells.

PubMed

Liu, Li; Ma, Hongyue; Tang, Yuping; Chen, Wenxing; Lu, Yin; Guo, Jianming; Duan, Jin-Ao

2012-01-01

The binding between the estrogen receptor α (ER-α) and a variety of compounds in traditional Chinese formulae, Si-Wu-Tang (SWT) series decoctions, was studied using a stably-transfected human breast cancer cell line (MVLN). In 38 compounds tested from SWT series decoctions, the estrogen-like activity of 22 compounds was above 60% in 20 μg mL(-1). Furthermore, theoretical affinity of these compounds was certificated using the functional virtual screen of ER-α modulators by FlexX-Pharm. The accuracy of functional virtual screening of ER-α modulators could reach to 77.27%. The results showed that some compounds, such as organic acids and flavones in SWT series decoctions could be used as selective estrogen receptor modulators (SERMs) and could be selected for further development as potential agents for estrogen related diseases. Copyright © 2011 Elsevier Ltd. All rights reserved.

Analysis of the Correlation between Environmental Performance in Enterprise Green Management and the Competitive Edge

NASA Astrophysics Data System (ADS)

Li, Xing; Yang, Zihan; Zhang, Peiyao

2017-03-01

In recent years, there has been an increasing concern over the topics of enterprise green management and environmental performance’s influence on a company’s competitive edge. This paper mainly analyzed the effect of enterprise green management on a company’s environmental performance and its competitive advantages, as well as environmental performance’s influence over the competitive edge. Furthermore, this paper discussed the role of environmental performance between enterprise green management and competitive edge. Objects of this study are manufactures in northwestern China which have acquired the ISO 9001 certification before December, 2014. Research discoveries shows that enterprise green management would exert positive influence on the environmental performance and its competitive edge; the environmental performance could also add significant competitive edge to a company; last but not the least, environmental performance also plays an intermediary role between enterprise green management and its competitive advantages

42 CFR 493.53 - Notification requirements for laboratories issued a certificate for provider-performed microscopy...

Code of Federal Regulations, 2012 CFR

2012-10-01

... certificate for provider-performed microscopy (PPM) procedures. 493.53 Section 493.53 Public Health CENTERS... CERTIFICATION LABORATORY REQUIREMENTS Registration Certificate, Certificate for Provider-performed Microscopy... certificate for provider-performed microscopy (PPM) procedures. Laboratories issued a certificate for PPM...

42 CFR 493.53 - Notification requirements for laboratories issued a certificate for provider-performed microscopy...

Code of Federal Regulations, 2013 CFR

2013-10-01

... certificate for provider-performed microscopy (PPM) procedures. 493.53 Section 493.53 Public Health CENTERS... CERTIFICATION LABORATORY REQUIREMENTS Registration Certificate, Certificate for Provider-performed Microscopy... certificate for provider-performed microscopy (PPM) procedures. Laboratories issued a certificate for PPM...

42 CFR 493.53 - Notification requirements for laboratories issued a certificate for provider-performed microscopy...

Code of Federal Regulations, 2011 CFR

2011-10-01

... certificate for provider-performed microscopy (PPM) procedures. 493.53 Section 493.53 Public Health CENTERS... CERTIFICATION LABORATORY REQUIREMENTS Registration Certificate, Certificate for Provider-performed Microscopy... certificate for provider-performed microscopy (PPM) procedures. Laboratories issued a certificate for PPM...

42 CFR 493.53 - Notification requirements for laboratories issued a certificate for provider-performed microscopy...

Code of Federal Regulations, 2014 CFR

2014-10-01

... certificate for provider-performed microscopy (PPM) procedures. 493.53 Section 493.53 Public Health CENTERS... CERTIFICATION LABORATORY REQUIREMENTS Registration Certificate, Certificate for Provider-performed Microscopy... certificate for provider-performed microscopy (PPM) procedures. Laboratories issued a certificate for PPM...

42 CFR 493.53 - Notification requirements for laboratories issued a certificate for provider-performed microscopy...

Code of Federal Regulations, 2010 CFR

2010-10-01

... certificate for provider-performed microscopy (PPM) procedures. 493.53 Section 493.53 Public Health CENTERS... CERTIFICATION LABORATORY REQUIREMENTS Registration Certificate, Certificate for Provider-performed Microscopy... certificate for provider-performed microscopy (PPM) procedures. Laboratories issued a certificate for PPM...

75 FR 70871 - Photo Requirements for Pilot Certificates

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-19

... Prevention Act (IRTPA). The FAA previously required all pilots to obtain a plastic certificate (excepting... pilots to obtain a plastic certificate with photo. Student pilot certificates would also have the same... certificates and began issuing plastic airman certificates in 2003. The plastic certificates are of high...

IMG-ABC: A Knowledge Base To Fuel Discovery of Biosynthetic Gene Clusters and Novel Secondary Metabolites.

PubMed

Hadjithomas, Michalis; Chen, I-Min Amy; Chu, Ken; Ratner, Anna; Palaniappan, Krishna; Szeto, Ernest; Huang, Jinghua; Reddy, T B K; Cimermančič, Peter; Fischbach, Michael A; Ivanova, Natalia N; Markowitz, Victor M; Kyrpides, Nikos C; Pati, Amrita

2015-07-14

In the discovery of secondary metabolites, analysis of sequence data is a promising exploration path that remains largely underutilized due to the lack of computational platforms that enable such a systematic approach on a large scale. In this work, we present IMG-ABC (https://img.jgi.doe.gov/abc), an atlas of biosynthetic gene clusters within the Integrated Microbial Genomes (IMG) system, which is aimed at harnessing the power of "big" genomic data for discovering small molecules. IMG-ABC relies on IMG's comprehensive integrated structural and functional genomic data for the analysis of biosynthetic gene clusters (BCs) and associated secondary metabolites (SMs). SMs and BCs serve as the two main classes of objects in IMG-ABC, each with a rich collection of attributes. A unique feature of IMG-ABC is the incorporation of both experimentally validated and computationally predicted BCs in genomes as well as metagenomes, thus identifying BCs in uncultured populations and rare taxa. We demonstrate the strength of IMG-ABC's focused integrated analysis tools in enabling the exploration of microbial secondary metabolism on a global scale, through the discovery of phenazine-producing clusters for the first time in Alphaproteobacteria. IMG-ABC strives to fill the long-existent void of resources for computational exploration of the secondary metabolism universe; its underlying scalable framework enables traversal of uncovered phylogenetic and chemical structure space, serving as a doorway to a new era in the discovery of novel molecules. IMG-ABC is the largest publicly available database of predicted and experimental biosynthetic gene clusters and the secondary metabolites they produce. The system also includes powerful search and analysis tools that are integrated with IMG's extensive genomic/metagenomic data and analysis tool kits. As new research on biosynthetic gene clusters and secondary metabolites is published and more genomes are sequenced, IMG-ABC will continue to expand, with the goal of becoming an essential component of any bioinformatic exploration of the secondary metabolism world. Copyright © 2015 Hadjithomas et al.

Minimum Climb to Cruise Noise Trajectories Modeled for the High Speed Civil Transport

NASA Technical Reports Server (NTRS)

Berton, Jeffrey J.

1998-01-01

The proposed U.S. High Speed Civil Transport (HSCT) will revolutionize commercial air travel by providing economical supersonic passenger service to destinations worldwide. Unlike the high-bypass turbofan engines that propel today's subsonic airliners, HSCT engines will have much higher jet exhaust speeds. Jet noise, caused by the turbulent mixing of high-speed exhaust with the surrounding air, poses a significant challenge for HSCT engine designers. To resolve this challenge, engineers have designed advanced mixer rejector nozzles that reduce HSCT jet noise to airport noise certification levels by entraining and mixing large quantities of ambient air with the engines' jet streams. Although this works well during the first several minutes of flight, far away from the airport, as the HSCT gains speed and climbs, poor ejector inlet recovery and ejector ram drag contribute to poor thrust, making it advantageous to turn off the ejector. Doing so prematurely, however, can cause unacceptable noise levels to propagate to the ground, even when the aircraft is many miles from the airport. This situation lends itself ideally to optimization, where the aircraft trajectory, throttle setting, and ejector setting can be varied (subject to practical aircraft constraints) to minimize the noise propagated to the ground. A method was developed at the NASA Lewis Research Center that employs a variation of the classic energy state approximation: a trajectory analysis technique historically used to minimize climb time or fuel burned in many aircraft problems. To minimize the noise on the ground at any given throttle setting, high aircraft altitudes are desirable; but the HSCT may either climb quickly to high altitudes using a high, noisy throttle setting or climb more slowly at a lower, quieter throttle setting. An optimizer has been programmed into NASA's existing aircraft and noise analysis codes to balance these options by dynamically choosing the best altitude-velocity path and throttle setting history. The noise level standard, or metric, used in the optimizer should be one that accurately reflects the subjective annoyance levels of ground-based observers under the flight path. A variety of noise metrics are available, many of which are practical for airport-vicinity noise certification. Unlike airport noise, however, the HSCT's climb noise will be characterized by relatively low noise levels, long durations, and low-frequency spectra. The noise metrics used in these calculations are based on the recommendations of researchers at the NASA Langley Research Center, who have correlated the flyover noise annoyance levels of actual laboratory subjects with a variety of measurements. Analysis of data from this optimizer has shown that significant reductions in noise may be obtained with trajectory optimization. And since throttling operations are performed in the subsonic portion of the climb path (where thrust is plentiful), only small penalties in HSCT range or fuel performance occur.

Working Group Report: Dark Matter Complementarity (Dark Matter in the Coming Decade: Complementary Paths to Discovery and Beyond)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Arrenberg, Sebastian; et al.,

2013-10-31

In this Report we discuss the four complementary searches for the identity of dark matter: direct detection experiments that look for dark matter interacting in the lab, indirect detection experiments that connect lab signals to dark matter in our own and other galaxies, collider experiments that elucidate the particle properties of dark matter, and astrophysical probes sensitive to non-gravitational interactions of dark matter. The complementarity among the different dark matter searches is discussed qualitatively and illustrated quantitatively in several theoretical scenarios. Our primary conclusion is that the diversity of possible dark matter candidates requires a balanced program based on allmore » four of those approaches.« less

East-West paths to unconventional computing.

PubMed

Adamatzky, Andrew; Akl, Selim; Burgin, Mark; Calude, Cristian S; Costa, José Félix; Dehshibi, Mohammad Mahdi; Gunji, Yukio-Pegio; Konkoli, Zoran; MacLennan, Bruce; Marchal, Bruno; Margenstern, Maurice; Martínez, Genaro J; Mayne, Richard; Morita, Kenichi; Schumann, Andrew; Sergeyev, Yaroslav D; Sirakoulis, Georgios Ch; Stepney, Susan; Svozil, Karl; Zenil, Hector

2017-12-01

Unconventional computing is about breaking boundaries in thinking, acting and computing. Typical topics of this non-typical field include, but are not limited to physics of computation, non-classical logics, new complexity measures, novel hardware, mechanical, chemical and quantum computing. Unconventional computing encourages a new style of thinking while practical applications are obtained from uncovering and exploiting principles and mechanisms of information processing in and functional properties of, physical, chemical and living systems; in particular, efficient algorithms are developed, (almost) optimal architectures are designed and working prototypes of future computing devices are manufactured. This article includes idiosyncratic accounts of 'unconventional computing' scientists reflecting on their personal experiences, what attracted them to the field, their inspirations and discoveries. Copyright © 2017 Elsevier Ltd. All rights reserved.

Lessons from Retinoblastoma: Implications for Cancer, Development, Evolution, and Regenerative Medicine.

PubMed

Dyer, Michael A

2016-10-01

Retinoblastoma is a rare childhood cancer of the developing retina, and studies on this orphan disease have led to fundamental discoveries in cancer biology. Retinoblastoma has also emerged as a model for translational research for pediatric solid tumors, which is particularly important as personalized medicine expands in oncology. Research on retinoblastomas has been combined with the exploration of retinal development and retinal degeneration to advance a new model of cell type-specific disease susceptibility termed 'cellular pliancy'. The concept can even be extended to species-specific regeneration. This review discusses the remarkable path of retinoblastoma research and how it has shaped the most current efforts in basic, translational, and clinical research in oncology and beyond. Copyright © 2016 Elsevier Ltd. All rights reserved.

Life in cellulose houses: Symbiotic bacterial biosynthesis of ascidian drugs and drug leads

PubMed Central

Schmidt, Eric W.; Donia, Mohamed S.

2010-01-01

Ascidians (tunicates; sea squirts) are sources of diverse, bioactive natural products, one of which is an approved drug and many of which are potent drug leads. It has been shown that symbiotic bacteria living with ascidians produce some of the bioactive compounds isolated from whole animals, and indirect evidence strongly implicates symbiotic bacteria in the synthesis of many others. However, for the majority the producing organism has not been identified. In cases where a symbiotic origin has been definitively assigned, the resulting data lead to improved paths to drug discovery and development from marine animals. This review traces evidence for symbiotic production where such evidence exists and describes the strengths and limitations of that evidence. PMID:21050742

Integrated Bio-Entity Network: A System for Biological Knowledge Discovery

PubMed Central

Bell, Lindsey; Chowdhary, Rajesh; Liu, Jun S.; Niu, Xufeng; Zhang, Jinfeng

2011-01-01

A significant part of our biological knowledge is centered on relationships between biological entities (bio-entities) such as proteins, genes, small molecules, pathways, gene ontology (GO) terms and diseases. Accumulated at an increasing speed, the information on bio-entity relationships is archived in different forms at scattered places. Most of such information is buried in scientific literature as unstructured text. Organizing heterogeneous information in a structured form not only facilitates study of biological systems using integrative approaches, but also allows discovery of new knowledge in an automatic and systematic way. In this study, we performed a large scale integration of bio-entity relationship information from both databases containing manually annotated, structured information and automatic information extraction of unstructured text in scientific literature. The relationship information we integrated in this study includes protein–protein interactions, protein/gene regulations, protein–small molecule interactions, protein–GO relationships, protein–pathway relationships, and pathway–disease relationships. The relationship information is organized in a graph data structure, named integrated bio-entity network (IBN), where the vertices are the bio-entities and edges represent their relationships. Under this framework, graph theoretic algorithms can be designed to perform various knowledge discovery tasks. We designed breadth-first search with pruning (BFSP) and most probable path (MPP) algorithms to automatically generate hypotheses—the indirect relationships with high probabilities in the network. We show that IBN can be used to generate plausible hypotheses, which not only help to better understand the complex interactions in biological systems, but also provide guidance for experimental designs. PMID:21738677

The Discovery of the Electromagnetic Counterpart of GW170817: Kilonova AT 2017gfo/DLT17ck

NASA Astrophysics Data System (ADS)

Valenti, Stefano; David; Sand, J.; Yang, Sheng; Cappellaro, Enrico; Tartaglia, Leonardo; Corsi, Alessandra; Jha, Saurabh W.; Reichart, Daniel E.; Haislip, Joshua; Kouprianov, Vladimir

2017-10-01

During the second observing run of the Laser Interferometer Gravitational-wave Observatory (LIGO) and Virgo Interferometer, a gravitational-wave signal consistent with a binary neutron star coalescence was detected on 2017 August 17th (GW170817), quickly followed by a coincident short gamma-ray burst trigger detected by the Fermi satellite. The Distance Less Than 40 (DLT40) Mpc supernova search performed pointed follow-up observations of a sample of galaxies regularly monitored by the survey that fell within the combined LIGO+Virgo localization region and the larger Fermi gamma-ray burst error box. Here we report the discovery of a new optical transient (DLT17ck, also known as SSS17a; it has also been registered as AT 2017gfo) spatially and temporally coincident with GW170817. The photometric and spectroscopic evolution of DLT17ck is unique, with an absolute peak magnitude of M r = -15.8 ± 0.1 and an r-band decline rate of 1.1 mag day-1. This fast evolution is generically consistent with kilonova models, which have been predicted as the optical counterpart to binary neutron star coalescences. Analysis of archival DLT40 data does not show any sign of transient activity at the location of DLT17ck down to r ˜ 19 mag in the time period between 8 months and 21 days prior to GW170817. This discovery represents the beginning of a new era for multi-messenger astronomy, opening a new path by which to study and understand binary neutron star coalescences, short gamma-ray bursts, and their optical counterparts.

Undergraduates' Intentions to Take Examinations for Professional Certification: Examinations of Four Competing Models

ERIC Educational Resources Information Center

Cheng, Pi-Yueh; Hsu, Ping-Kun; Chiou, Wen-Bin

2012-01-01

Previous research on professional certification has primarily focused on graduate certificates in intensive care nursing, writing certificates for practitioners, maintenance of certification in radiation oncology, and the certification of teachers and surgeons. Research on certification in the domain of business and management from an…

21 CFR 80.35 - Color additive mixtures; certification and exemption from certification.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 21 Food and Drugs 1 2012-04-01 2012-04-01 false Color additive mixtures; certification and... HEALTH AND HUMAN SERVICES GENERAL COLOR ADDITIVE CERTIFICATION Certification Procedures § 80.35 Color additive mixtures; certification and exemption from certification. (a) Color additive mixtures to be...

21 CFR 80.35 - Color additive mixtures; certification and exemption from certification.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 21 Food and Drugs 1 2013-04-01 2013-04-01 false Color additive mixtures; certification and... HEALTH AND HUMAN SERVICES GENERAL COLOR ADDITIVE CERTIFICATION Certification Procedures § 80.35 Color additive mixtures; certification and exemption from certification. (a) Color additive mixtures to be...

21 CFR 80.35 - Color additive mixtures; certification and exemption from certification.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 21 Food and Drugs 1 2014-04-01 2014-04-01 false Color additive mixtures; certification and... HEALTH AND HUMAN SERVICES GENERAL COLOR ADDITIVE CERTIFICATION Certification Procedures § 80.35 Color additive mixtures; certification and exemption from certification. (a) Color additive mixtures to be...

Rational confederation of genes and diseases: NGS interpretation via GeneCards, MalaCards and VarElect.

PubMed

Rappaport, Noa; Fishilevich, Simon; Nudel, Ron; Twik, Michal; Belinky, Frida; Plaschkes, Inbar; Stein, Tsippi Iny; Cohen, Dana; Oz-Levi, Danit; Safran, Marilyn; Lancet, Doron

2017-08-18

A key challenge in the realm of human disease research is next generation sequencing (NGS) interpretation, whereby identified filtered variant-harboring genes are associated with a patient's disease phenotypes. This necessitates bioinformatics tools linked to comprehensive knowledgebases. The GeneCards suite databases, which include GeneCards (human genes), MalaCards (human diseases) and PathCards (human pathways) together with additional tools, are presented with the focus on MalaCards utility for NGS interpretation as well as for large scale bioinformatic analyses. VarElect, our NGS interpretation tool, leverages the broad information in the GeneCards suite databases. MalaCards algorithms unify disease-related terms and annotations from 69 sources. Further, MalaCards defines hierarchical relatedness-aliases, disease families, a related diseases network, categories and ontological classifications. GeneCards and MalaCards delineate and share a multi-tiered, scored gene-disease network, with stringency levels, including the definition of elite status-high quality gene-disease pairs, coming from manually curated trustworthy sources, that includes 4500 genes for 8000 diseases. This unique resource is key to NGS interpretation by VarElect. VarElect, a comprehensive search tool that helps infer both direct and indirect links between genes and user-supplied disease/phenotype terms, is robustly strengthened by the information found in MalaCards. The indirect mode benefits from GeneCards' diverse gene-to-gene relationships, including SuperPaths-integrated biological pathways from 12 information sources. We are currently adding an important information layer in the form of "disease SuperPaths", generated from the gene-disease matrix by an algorithm similar to that previously employed for biological pathway unification. This allows the discovery of novel gene-disease and disease-disease relationships. The advent of whole genome sequencing necessitates capacities to go beyond protein coding genes. GeneCards is highly useful in this respect, as it also addresses 101,976 non-protein-coding RNA genes. In a more recent development, we are currently adding an inclusive map of regulatory elements and their inferred target genes, generated by integration from 4 resources. MalaCards provides a rich big-data scaffold for in silico biomedical discovery within the gene-disease universe. VarElect, which depends significantly on both GeneCards and MalaCards power, is a potent tool for supporting the interpretation of wet-lab experiments, notably NGS analyses of disease. The GeneCards suite has thus transcended its 2-decade role in biomedical research, maturing into a key player in clinical investigation.

78 FR 64153 - Direct Certification and Certification of Homeless, Migrant and Runaway Children for Free School...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-28

...-0001] RIN 0584-AD60 Direct Certification and Certification of Homeless, Migrant and Runaway Children... interim rule entitled Direct Certification and Certification of Homeless, Migrant and Runaway Children for...

A Stochastic Sprint in the Vague Direction of Data Science: Perspectives from a Graduate Student and Aspiring Data Scientist.

NASA Astrophysics Data System (ADS)

Barberie, S. R.

2015-12-01

Since data science does not exist as a stand-alone discipline within major universities, learning data science, or even learning that data science exists is, for an aspiring researcher at the graduate or undergraduate level, something that only happens by accident. Here I present my own series of accidents that transformed me from a somewhat aimless graduate student into an aspiring data scientist and the challenges that that aspiration has created in fitting into traditional academic programs and finding a coherent path forward. I also present my current conundrum: with the clear intention of pursuing data science but an academic background in other subjects, where do I go from here? Do I start my education over, pursue professional certification courses and bootcamp programs, or engage in not-very-marketable self study? This career chasm creates a strange environment for aspiring data scientists where we have a destination, but not a clear road to get there. I also discuss how joining a data focused interest group called The Federation of Earth Science Information Partners (ESIP) bridged some of the gap left by Academia in allowing me to network and collaborate with real data scientists from a variety of backgrounds. Organizations like this may someday play an important role in helping aspiring data scientists find their place, although for the moment many gaps and obstacles still remain, and the path forward is far from clear.

42 CFR 488.12 - Effect of survey agency certification.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 5 2010-10-01 2010-10-01 false Effect of survey agency certification. 488.12... SERVICES (CONTINUED) STANDARDS AND CERTIFICATION SURVEY, CERTIFICATION, AND ENFORCEMENT PROCEDURES General Provisions § 488.12 Effect of survey agency certification. Certifications by the State survey agency...

14 CFR 61.23 - Medical certificates: Requirement and duration.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false Medical certificates: Requirement and....23 Medical certificates: Requirement and duration. (a) Operations requiring a medical certificate... medical certificate: (i) When exercising the privileges of an airline transport pilot certificate; or (ii...

16 CFR 1110.13 - Availability of electronic certificate.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Availability of electronic certificate. 1110... ACT REGULATIONS CERTIFICATES OF COMPLIANCE § 1110.13 Availability of electronic certificate. (a) CPSA... electronic certificate satisfies the “accompany” requirement if the certificate is identified by a unique...

16 CFR 1110.13 - Availability of electronic certificate.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 16 Commercial Practices 2 2014-01-01 2014-01-01 false Availability of electronic certificate. 1110... ACT REGULATIONS CERTIFICATES OF COMPLIANCE § 1110.13 Availability of electronic certificate. (a) CPSA... electronic certificate satisfies the “accompany” requirement if the certificate is identified by a unique...

16 CFR 1110.13 - Availability of electronic certificate.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 16 Commercial Practices 2 2012-01-01 2012-01-01 false Availability of electronic certificate. 1110... ACT REGULATIONS CERTIFICATES OF COMPLIANCE § 1110.13 Availability of electronic certificate. (a) CPSA... electronic certificate satisfies the “accompany” requirement if the certificate is identified by a unique...

16 CFR 1110.13 - Availability of electronic certificate.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 16 Commercial Practices 2 2011-01-01 2011-01-01 false Availability of electronic certificate. 1110... ACT REGULATIONS CERTIFICATES OF COMPLIANCE § 1110.13 Availability of electronic certificate. (a) CPSA... electronic certificate satisfies the “accompany” requirement if the certificate is identified by a unique...

10 CFR 76.51 - Conditions of certification.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 2 2011-01-01 2011-01-01 false Conditions of certification. 76.51 Section 76.51 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) CERTIFICATION OF GASEOUS DIFFUSION PLANTS Certification § 76.51 Conditions of certification. The Corporation shall comply with the certificate of compliance, any approved...

10 CFR 76.51 - Conditions of certification.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 2 2014-01-01 2014-01-01 false Conditions of certification. 76.51 Section 76.51 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) CERTIFICATION OF GASEOUS DIFFUSION PLANTS Certification § 76.51 Conditions of certification. The Corporation shall comply with the certificate of compliance, any approved...

10 CFR 76.51 - Conditions of certification.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 2 2010-01-01 2010-01-01 false Conditions of certification. 76.51 Section 76.51 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) CERTIFICATION OF GASEOUS DIFFUSION PLANTS Certification § 76.51 Conditions of certification. The Corporation shall comply with the certificate of compliance, any approved...

10 CFR 76.51 - Conditions of certification.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 2 2013-01-01 2013-01-01 false Conditions of certification. 76.51 Section 76.51 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) CERTIFICATION OF GASEOUS DIFFUSION PLANTS Certification § 76.51 Conditions of certification. The Corporation shall comply with the certificate of compliance, any approved...

10 CFR 76.51 - Conditions of certification.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 2 2012-01-01 2012-01-01 false Conditions of certification. 76.51 Section 76.51 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) CERTIFICATION OF GASEOUS DIFFUSION PLANTS Certification § 76.51 Conditions of certification. The Corporation shall comply with the certificate of compliance, any approved...

14 CFR 47.71 - Duration of Certificate; change of status.

Code of Federal Regulations, 2013 CFR

2013-01-01

... TRANSPORTATION AIRCRAFT AIRCRAFT REGISTRATION Dealers' Aircraft Registration Certificate § 47.71 Duration of Certificate; change of status. (a) A Dealer's Aircraft Registration Certificate, AC Form 8050-6, expires 1... certificate expires. (b) The holder of a Dealer's Aircraft Registration Certificate must immediately notify...

14 CFR 47.71 - Duration of Certificate; change of status.

Code of Federal Regulations, 2012 CFR

2012-01-01

... TRANSPORTATION AIRCRAFT AIRCRAFT REGISTRATION Dealers' Aircraft Registration Certificate § 47.71 Duration of Certificate; change of status. (a) A Dealer's Aircraft Registration Certificate, AC Form 8050-6, expires 1... certificate expires. (b) The holder of a Dealer's Aircraft Registration Certificate must immediately notify...

14 CFR 47.71 - Duration of Certificate; change of status.

Code of Federal Regulations, 2014 CFR

2014-01-01

... TRANSPORTATION AIRCRAFT AIRCRAFT REGISTRATION Dealers' Aircraft Registration Certificate § 47.71 Duration of Certificate; change of status. (a) A Dealer's Aircraft Registration Certificate, AC Form 8050-6, expires 1... certificate expires. (b) The holder of a Dealer's Aircraft Registration Certificate must immediately notify...

14 CFR 47.49 - Replacement of Certificate.

Code of Federal Regulations, 2010 CFR

2010-01-01

... AIRCRAFT REGISTRATION Certificates of Aircraft Registration § 47.49 Replacement of Certificate. (a) If a Certificate of Aircraft Registration is lost, stolen, or mutilated, the holder of the Certificate of Aircraft Registration may apply to the FAA Aircraft Registry for a duplicate certificate, accompanying his application...

14 CFR 47.71 - Duration of Certificate; change of status.

Code of Federal Regulations, 2011 CFR

2011-01-01

... TRANSPORTATION AIRCRAFT AIRCRAFT REGISTRATION Dealers' Aircraft Registration Certificate § 47.71 Duration of Certificate; change of status. (a) A Dealer's Aircraft Registration Certificate, AC Form 8050-6, expires 1... certificate expires. (b) The holder of a Dealer's Aircraft Registration Certificate must immediately notify...

7 CFR 160.61 - Kinds of certificates issued.

Code of Federal Regulations, 2013 CFR

2013-01-01

.... The kind of certificates issued are as follows: (a) Turpentine analysis and classification certificate. (b) Turpentine field classification certificate. (c) Rosin classification and grade certificate. (d...

7 CFR 160.61 - Kinds of certificates issued.

Code of Federal Regulations, 2014 CFR

2014-01-01

.... The kind of certificates issued are as follows: (a) Turpentine analysis and classification certificate. (b) Turpentine field classification certificate. (c) Rosin classification and grade certificate. (d...

7 CFR 160.61 - Kinds of certificates issued.

Code of Federal Regulations, 2011 CFR

2011-01-01

.... The kind of certificates issued are as follows: (a) Turpentine analysis and classification certificate. (b) Turpentine field classification certificate. (c) Rosin classification and grade certificate. (d...

7 CFR 160.61 - Kinds of certificates issued.

Code of Federal Regulations, 2012 CFR

2012-01-01

.... The kind of certificates issued are as follows: (a) Turpentine analysis and classification certificate. (b) Turpentine field classification certificate. (c) Rosin classification and grade certificate. (d...

46 CFR 8.320 - Classification society authorization to issue international certificates.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Safety Equipment Certificate; (5) International Certificate of Fitness for the Carriage of Dangerous Chemicals in Bulk; (6) International Certificate of Fitness for the Carriage of Liquefied Gases in Bulk; (7... Certificate; (11) High-Speed Craft Safety Certificate; (12) MARPOL 73/78 International Air Pollution...

46 CFR 8.320 - Classification society authorization to issue international certificates.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Safety Equipment Certificate; (5) International Certificate of Fitness for the Carriage of Dangerous Chemicals in Bulk; (6) International Certificate of Fitness for the Carriage of Liquefied Gases in Bulk; (7... Certificate; (11) High-Speed Craft Safety Certificate; (12) MARPOL 73/78 International Air Pollution...

46 CFR 8.320 - Classification society authorization to issue international certificates.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Safety Equipment Certificate; (5) International Certificate of Fitness for the Carriage of Dangerous Chemicals in Bulk; (6) International Certificate of Fitness for the Carriage of Liquefied Gases in Bulk; (7... Certificate; (11) High-Speed Craft Safety Certificate; (12) MARPOL 73/78 International Air Pollution...

46 CFR 91.60-40 - Duration of Convention certificates.

Code of Federal Regulations, 2010 CFR

2010-10-01

... VESSELS INSPECTION AND CERTIFICATION Certificates Under International Convention for Safety of Life at Sea... period of not more than 60 months. (1) A Cargo Ship Safety Construction Certificate. (2) A Cargo Ship Safety Equipment Certificate. (3) A Safety Management Certificate. (4) A Cargo Ship Safety Radio...

14 CFR 147.35 - Transcripts and graduation certificates.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Transcripts and graduation certificates... Operating Rules § 147.35 Transcripts and graduation certificates. (a) Upon request, each certificated... received. (b) Each school shall give a graduation certificate or certificate of completion to each student...

14 CFR 147.35 - Transcripts and graduation certificates.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Transcripts and graduation certificates... Operating Rules § 147.35 Transcripts and graduation certificates. (a) Upon request, each certificated... received. (b) Each school shall give a graduation certificate or certificate of completion to each student...

14 CFR 147.35 - Transcripts and graduation certificates.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Transcripts and graduation certificates... Operating Rules § 147.35 Transcripts and graduation certificates. (a) Upon request, each certificated... received. (b) Each school shall give a graduation certificate or certificate of completion to each student...

14 CFR 147.35 - Transcripts and graduation certificates.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Transcripts and graduation certificates... Operating Rules § 147.35 Transcripts and graduation certificates. (a) Upon request, each certificated... received. (b) Each school shall give a graduation certificate or certificate of completion to each student...

42 CFR 418.22 - Certification of terminal illness.

Code of Federal Regulations, 2010 CFR

2010-10-01

... certification of terminal illness for each of the periods listed in § 418.21, even if a single election... certification. Certification will be based on the physician's or medical director's clinical judgment regarding... certification or recertification form, in addition to the physician's signature on the certification or...

47 CFR 54.410 - Certification and Verification of Consumer Qualification for Lifeline.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 47 Telecommunication 3 2010-10-01 2010-10-01 false Certification and Verification of Consumer... § 54.410 Certification and Verification of Consumer Qualification for Lifeline. (a) Certification of... within that calendar year. (b) Self-certifications. After income certification procedures are implemented...

16 CFR § 1110.13 - Availability of electronic certificate.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 16 Commercial Practices 2 2013-01-01 2013-01-01 false Availability of electronic certificate. Â... SAFETY ACT REGULATIONS CERTIFICATES OF COMPLIANCE § 1110.13 Availability of electronic certificate. (a.... (1) An electronic certificate satisfies the “accompany” requirement if the certificate is identified...

10 CFR 76.65 - Inalienability of certificates.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 2 2011-01-01 2011-01-01 false Inalienability of certificates. 76.65 Section 76.65 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) CERTIFICATION OF GASEOUS DIFFUSION PLANTS Certification § 76.65 Inalienability of certificates. The certificate granted under the regulations in this part may not be transferred...

10 CFR 76.65 - Inalienability of certificates.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 2 2014-01-01 2014-01-01 false Inalienability of certificates. 76.65 Section 76.65 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) CERTIFICATION OF GASEOUS DIFFUSION PLANTS Certification § 76.65 Inalienability of certificates. The certificate granted under the regulations in this part may not be transferred...

10 CFR 76.65 - Inalienability of certificates.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 2 2013-01-01 2013-01-01 false Inalienability of certificates. 76.65 Section 76.65 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) CERTIFICATION OF GASEOUS DIFFUSION PLANTS Certification § 76.65 Inalienability of certificates. The certificate granted under the regulations in this part may not be transferred...

10 CFR 76.65 - Inalienability of certificates.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 2 2012-01-01 2012-01-01 false Inalienability of certificates. 76.65 Section 76.65 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) CERTIFICATION OF GASEOUS DIFFUSION PLANTS Certification § 76.65 Inalienability of certificates. The certificate granted under the regulations in this part may not be transferred...

10 CFR 76.65 - Inalienability of certificates.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 2 2010-01-01 2010-01-01 false Inalienability of certificates. 76.65 Section 76.65 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) CERTIFICATION OF GASEOUS DIFFUSION PLANTS Certification § 76.65 Inalienability of certificates. The certificate granted under the regulations in this part may not be transferred...

Certification Manual for Wisconsin Public Librarians. Bulletin No. 94111.

ERIC Educational Resources Information Center

Lamb, Donald K.

This manual contains the guidelines and procedures for public librarian certification and certification renewal in Wisconsin. Certification is not required for library personnel other than administrators, but nonadministrators may apply for certification at the level for which they are eligible. Requirements for voluntary library certification are…

14 CFR 21.41 - Type certificate.

Code of Federal Regulations, 2013 CFR

2013-01-01

... PROCEDURES FOR PRODUCTS AND PARTS Type Certificates § 21.41 Type certificate. Each type certificate is considered to include the type design, the operating limitations, the certificate data sheet, the applicable... 14 Aeronautics and Space 1 2013-01-01 2013-01-01 false Type certificate. 21.41 Section 21.41...

14 CFR 21.41 - Type certificate.

Code of Federal Regulations, 2014 CFR

2014-01-01

... PROCEDURES FOR PRODUCTS AND PARTS Type Certificates § 21.41 Type certificate. Each type certificate is considered to include the type design, the operating limitations, the certificate data sheet, the applicable... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Type certificate. 21.41 Section 21.41...

14 CFR 21.41 - Type certificate.

Code of Federal Regulations, 2011 CFR

2011-01-01

... PROCEDURES FOR PRODUCTS AND PARTS Type Certificates § 21.41 Type certificate. Each type certificate is considered to include the type design, the operating limitations, the certificate data sheet, the applicable... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Type certificate. 21.41 Section 21.41...

14 CFR 21.41 - Type certificate.

Code of Federal Regulations, 2010 CFR

2010-01-01

... PROCEDURES FOR PRODUCTS AND PARTS Type Certificates § 21.41 Type certificate. Each type certificate is considered to include the type design, the operating limitations, the certificate data sheet, the applicable... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Type certificate. 21.41 Section 21.41...

14 CFR 21.41 - Type certificate.

Code of Federal Regulations, 2012 CFR

2012-01-01

... PROCEDURES FOR PRODUCTS AND PARTS Type Certificates § 21.41 Type certificate. Each type certificate is considered to include the type design, the operating limitations, the certificate data sheet, the applicable... 14 Aeronautics and Space 1 2012-01-01 2012-01-01 false Type certificate. 21.41 Section 21.41...

21 CFR 1311.15 - Limitations on CSOS digital certificates.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 9 2011-04-01 2011-04-01 false Limitations on CSOS digital certificates. 1311.15... ELECTRONIC ORDERS AND PRESCRIPTIONS Obtaining and Using Digital Certificates for Electronic Orders § 1311.15 Limitations on CSOS digital certificates. (a) A CSOS digital certificate issued by the DEA Certification...

40 CFR 91.122 - Amending the application and certificate of conformity.

Code of Federal Regulations, 2010 CFR

2010-07-01

... certificate of conformity. 91.122 Section 91.122 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Standards and Certification Provisions § 91.122 Amending the application and certificate of conformity. (a... to a certificate of conformity or changes are to be made to a product line covered by a certificate...

40 CFR 91.122 - Amending the application and certificate of conformity.

Code of Federal Regulations, 2011 CFR

2011-07-01

... certificate of conformity. 91.122 Section 91.122 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Standards and Certification Provisions § 91.122 Amending the application and certificate of conformity. (a... to a certificate of conformity or changes are to be made to a product line covered by a certificate...

14 CFR 125.27 - Issue of certificate.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Issue of certificate. 125.27 Section 125.27... AND OPERATORS FOR COMPENSATION OR HIRE: CERTIFICATION AND OPERATIONS CERTIFICATION AND OPERATIONS... Requirements § 125.27 Issue of certificate. (a) An applicant for a certificate under this subpart is entitled...

14 CFR 67.409 - Denial of medical certificate.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 2 2013-01-01 2013-01-01 false Denial of medical certificate. 67.409... (CONTINUED) AIRMEN MEDICAL STANDARDS AND CERTIFICATION Certification Procedures § 67.409 Denial of medical certificate. (a) Any person who is denied a medical certificate by an aviation medical examiner may, within 30...

14 CFR 67.409 - Denial of medical certificate.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 2 2014-01-01 2014-01-01 false Denial of medical certificate. 67.409... (CONTINUED) AIRMEN MEDICAL STANDARDS AND CERTIFICATION Certification Procedures § 67.409 Denial of medical certificate. (a) Any person who is denied a medical certificate by an aviation medical examiner may, within 30...

23 CFR 450.334 - Self-certifications and Federal certifications.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 23 Highways 1 2010-04-01 2010-04-01 false Self-certifications and Federal certifications. 450.334... Self-certifications and Federal certifications. (a) For all MPAs, concurrent with the submittal of the... discrimination on the basis of race, color, creed, national origin, sex, or age in employment or business...

17 CFR 210.12-26 - Certificate reserves.

Code of Federal Regulations, 2014 CFR

2014-04-01

... CONSERVATION ACT OF 1975 For Face-Amount Certificate Investment Companies § 210.12-26 Certificate reserves... (ii) the difference on a $1,000 face-amount certificate basis. (b) There shall be shown by footnote or... maturity amount of the certificate. Such information shall be stated on a $1,000 face-amount certificate...

14 CFR 139.205 - Amendment of Airport Certification Manual.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Amendment of Airport Certification Manual... CERTIFICATION OF AIRPORTS Airport Certification Manual § 139.205 Amendment of Airport Certification Manual. (a) Under § 139.3, the Regional Airports Division Manager may amend any Airport Certification Manual...

14 CFR 139.205 - Amendment of Airport Certification Manual.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Amendment of Airport Certification Manual... CERTIFICATION OF AIRPORTS Airport Certification Manual § 139.205 Amendment of Airport Certification Manual. (a) Under § 139.3, the Regional Airports Division Manager may amend any Airport Certification Manual...

14 CFR 139.205 - Amendment of Airport Certification Manual.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Amendment of Airport Certification Manual... CERTIFICATION OF AIRPORTS Airport Certification Manual § 139.205 Amendment of Airport Certification Manual. (a) Under § 139.3, the Regional Airports Division Manager may amend any Airport Certification Manual...

14 CFR 139.205 - Amendment of Airport Certification Manual.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Amendment of Airport Certification Manual... CERTIFICATION OF AIRPORTS Airport Certification Manual § 139.205 Amendment of Airport Certification Manual. (a) Under § 139.3, the Regional Airports Division Manager may amend any Airport Certification Manual...

13 CFR 120.1709 - Transfers of Pool Certificates.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 13 Business Credit and Assistance 1 2012-01-01 2012-01-01 false Transfers of Pool Certificates... Transfers of Pool Certificates. (a) Transfer of Pool Certificates. A Pool Certificate is transferable. A transfer of a Pool Certificate must comply with Article 8 of the Uniform Commercial Code of the State of...

13 CFR 120.1709 - Transfers of Pool Certificates.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Transfers of Pool Certificates... Transfers of Pool Certificates. (a) Transfer of Pool Certificates. A Pool Certificate is transferable. A transfer of a Pool Certificate must comply with Article 8 of the Uniform Commercial Code of the State of...

13 CFR 120.1709 - Transfers of Pool Certificates.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 13 Business Credit and Assistance 1 2014-01-01 2014-01-01 false Transfers of Pool Certificates... Transfers of Pool Certificates. (a) Transfer of Pool Certificates. A Pool Certificate is transferable. A transfer of a Pool Certificate must comply with Article 8 of the Uniform Commercial Code of the State of...

13 CFR 120.1709 - Transfers of Pool Certificates.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 13 Business Credit and Assistance 1 2011-01-01 2011-01-01 false Transfers of Pool Certificates... Transfers of Pool Certificates. (a) Transfer of Pool Certificates. A Pool Certificate is transferable. A transfer of a Pool Certificate must comply with Article 8 of the Uniform Commercial Code of the State of...

Evolutionary genomics of yeast pathogens in the Saccharomycotina

PubMed Central

Naranjo-Ortíz, Miguel A.; Marcet-Houben, Marina

2016-01-01

Saccharomycotina comprises a diverse group of yeasts that includes numerous species of industrial or clinical relevance. Opportunistic pathogens within this clade are often assigned to the genus Candida but belong to phylogenetically distant lineages that also comprise non-pathogenic species. This indicates that the ability to infect humans has evolved independently several times among Saccharomycotina. Although the mechanisms of infection of the main groups of Candida pathogens are starting to be unveiled, we still lack sufficient understanding of the evolutionary paths that led to a virulent phenotype in each of the pathogenic lineages. Deciphering what genomic changes underlie the evolutionary emergence of a virulence trait will not only aid the discovery of novel virulence mechanisms but it will also provide valuable information to understand how new pathogens emerge, and what clades may pose a future danger. Here we review recent comparative genomics efforts that have revealed possible evolutionary paths to pathogenesis in different lineages, focusing on the main three agents of candidiasis worldwide: Candida albicans, C. parapsilosis and C. glabrata. We will discuss what genomic traits may facilitate the emergence of virulence, and focus on two different genome evolution mechanisms able to generate drastic phenotypic changes and which have been associated to the emergence of virulence: gene family expansion and interspecies hybridization. PMID:27493146

Event-based criteria in GT-STAF information indices: theory, exploratory diversity analysis and QSPR applications.

PubMed

Barigye, S J; Marrero-Ponce, Y; Martínez López, Y; Martínez Santiago, O; Torrens, F; García Domenech, R; Galvez, J

2013-01-01

Versatile event-based approaches for the definition of novel information theory-based indices (IFIs) are presented. An event in this context is the criterion followed in the "discovery" of molecular substructures, which in turn serve as basis for the construction of the generalized incidence and relations frequency matrices, Q and F, respectively. From the resultant F, Shannon's, mutual, conditional and joint entropy-based IFIs are computed. In previous reports, an event named connected subgraphs was presented. The present study is an extension of this notion, in which we introduce other events, namely: terminal paths, vertex path incidence, quantum subgraphs, walks of length k, Sach's subgraphs, MACCs, E-state and substructure fingerprints and, finally, Ghose and Crippen atom-types for hydrophobicity and refractivity. Moreover, we define magnitude-based IFIs, introducing the use of the magnitude criterion in the definition of mutual, conditional and joint entropy-based IFIs. We also discuss the use of information-theoretic parameters as a measure of the dissimilarity of codified structural information of molecules. Finally, a comparison of the statistics for QSPR models obtained with the proposed IFIs and DRAGON's molecular descriptors for two physicochemical properties log P and log K of 34 derivatives of 2-furylethylenes demonstrates similar to better predictive ability than the latter.

Clinical research and the development of medical therapeutics.

PubMed

Antman, Elliott M

2014-01-01

Clinical research plays a central role in the development of medical therapeutics, but the current system is estimated to take 10-15 years from initial discovery to regulatory approval, at a cost of approximately US$1 billion. Contrast the paths by which 2 anticoagulant options for atrial fibrillation were discovered and ultimately established as treatment options in clinical medicine. Warfarin was discovered by serendipity and compared with placebo in relatively small trials; this was associated with a low cost of development. The new oral anticoagulants were synthesized to provide highly specific, targeted inhibition of critical steps in the coagulation system. They were compared with warfarin for prevention of stroke and systemic embolic events in large, phase 3 trials; this resulted in very expensive development programs. Neither of these paths is desirable for future development of therapeutics. We need to focus on innovative approaches at the preclinical level (systems approach, greater use of inducible pluripotent stem cells, use of novel bioengineering platforms) and clinical trial level (adaptive design, greater use of new and emerging technology). Focusing on disruptive innovations for development of medical therapeutics has the potential to bring us closer to the goal of precision medicine where safer, more effective treatments are discovered in a more efficient system.

Software Programs Derive Measurements from Photographs

NASA Technical Reports Server (NTRS)

2012-01-01

Even under the most unfortunate circumstances, NASA continues on a path of innovation. After the Space Shuttle Columbia reentered the atmosphere on February 1, 2003, it experienced a catastrophic failure, and the entire crew and vehicle were lost. For the two weeks prior to the accident, Columbia STS-107 was on a mission to perform physical, life, and space sciences research in the unique environment of microgravity. Following the accident, the remaining shuttles - Endeavor, Atlantis, and Discovery - were grounded, and an intense investigation ensued. The Columbia Accident Investigation Board spent nearly 7 months examining the cause of the accident and determining what would ensure a safe return to flight. To this end, investigators performed an extensive review down five analytic paths: aerodynamic, thermodynamic, sensor data timeline, debris reconstruction, and imaging. As part of the evaluation of all the available imagery from Columbia's ascent, orbit, and entry, investigators needed a new method for analyzing still video images to determine the size of the material that fell from Columbia, as well as the distance that the material traveled. John Lane, a scientist at Kennedy Space Center, devised a software program to calculate the unknown dimension of the material in the images, and soon after the investigation was complete, continued to enhance the technology. Eventually, the program that assisted in the Columbia investigation became available for licensing.

Discover the Cosmos - Bringing Cutting Edge Science to Schools across Europe

NASA Astrophysics Data System (ADS)

Doran, Rosa

2015-03-01

The fast growing number of science data repositories is opening enormous possibilities to scientists all over the world. The emergence of citizen science projects is engaging in science discovery a large number of citizens globally. Astronomical research is now a possibility to anyone having a computer and some form of data access. This opens a very interesting and strategic possibility to engage large audiences in the making and understanding of science. On another perspective it would be only natural to imagine that soon enough data mining will be an active part of the academic path of university or even secondary schools students. The possibility is very exciting but the road not very promising. Even in the most developed nations, where all schools are equipped with modern ICT facilities the use of such possibilities is still a very rare episode. The Galileo Teacher Training Program GTTP, a legacy of IYA2009, is participating in some of the most emblematic projects funded by the European Commission and targeting modern tools, resources and methodologies for science teaching. One of this projects is Discover the Cosmos which is aiming to target this issue by empowering educators with the necessary skills to embark on this innovative path: teaching science while doing science.

14 CFR 21.15 - Application for type certificate.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 1 2013-01-01 2013-01-01 false Application for type certificate. 21.15... CERTIFICATION PROCEDURES FOR PRODUCTS AND PARTS Type Certificates § 21.15 Application for type certificate. (a) An application for a type certificate is made on a form and in a manner prescribed by the FAA and is...

14 CFR 21.15 - Application for type certificate.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Application for type certificate. 21.15... CERTIFICATION PROCEDURES FOR PRODUCTS AND PARTS Type Certificates § 21.15 Application for type certificate. Link to an amendment published at 74 FR 53385, October 16, 2009. (a) An application for a type certificate...

Discovery of Novel NOx Catalysts for CIDI Applications by High-throughput Methods

DOE Office of Scientific and Technical Information (OSTI.GOV)

Blint, Richard J.

DOE project DE-PS26-00NT40758 has developed very active, lean exhaust, NOx reduction catalysts that have been tested on the discovery system, laboratory reactors and engine dynamometer systems. The goal of this project is the development of effective, affordable NOx reduction catalysts for lean combustion engines in the US light duty vehicle market which can meet Tier II emission standards with hydrocarbons based reductants for reducing NOx. General Motors (prime contractor) along with subcontractors BASF (Engelhard) (a catalytic converter developer) and ACCELRYS (an informatics supplier) carried out this project which began in August of 2002. BASF (Engelhard) has run over 16,000 testsmore » of 6100 possible catalytic materials on a high throughput discovery system suitable for automotive catalytic materials. Accelrys developed a new database informatics system which allowed material tracking and data mining. A program catalyst was identified and evaluated at all levels of the program. Dynamometer evaluations of the program catalyst both with and without additives show 92% NOx conversions on the HWFET, 76% on the US06, 60% on the cold FTP and 65% on the Set 13 heavy duty test using diesel fuel. Conversions of over 92% on the heavy duty FTP using ethanol as a second fluid reductant have been measured. These can be competitive with both of the alternative lean NOx reduction technologies presently in the market. Conversions of about 80% were measured on the EUDC for lean gasoline applications without using active dosing to adjust the C:N ratio for optimum NOx reduction at all points in the certification cycle. A feasibility analysis has been completed and demonstrates the advantages and disadvantages of the technology using these materials compared with other potential technologies. The teaming agreements among the partners contain no obstacles to commercialization of new technologies to any potential catalyst customers.« less

Mission safety evaluation report for STS-39, postflight edition

NASA Technical Reports Server (NTRS)

Hardie, Kenneth O.; Hill, William C.; Finkel, Seymour I.

1991-01-01

After a delay of approximately 2 months due to a rollback from the pad to replace the External Tank door lug housing, Space Shuttle Discovery was launched from NASA-Kennedy at 7:33 a.m. Eastern Daylight Time on 28 April 1991. STS-39 was the first unclassified DoD Shuttle mission. On 28 April, countdown proceeded normally through the T-20 minute hold. No significant problems were encountered except for the Operations Sequence-2 recorder starting unexpectedly; it was stopped by an uplink command. Discovery landed on KSC runway 15 at 2:55 p.m. EDT on 6 May 1991. This was the second time in 6 months that the Space Shuttle was diverted to KSC for landing because of high winds at Edwards AFB, Calif. This was also the 7th of 40 Shuttle missions to land at KSC in the history of the Space Shuttle Program. The Main Landing Gear outer right tire shredded 3 of the 16 cords due to either an uneven landing or a maximum force breaking test during rollout. Contributing factors to the tire cord shredding were the development of last minute crosswinds and reluctance of the ground controllers to distract the Shuttle pilots with warnings of the low flight path. As a corrective action, communication procedures will be modified for future flights.

Barriers to the Preclinical Development of Therapeutics that Target Aging Mechanisms.

PubMed

Burd, Christin E; Gill, Matthew S; Niedernhofer, Laura J; Robbins, Paul D; Austad, Steven N; Barzilai, Nir; Kirkland, James L

2016-11-01

Through the progress of basic science research, fundamental mechanisms that contribute to age-related decline are being described with increasing depth and detail. Although these efforts have identified new drug targets and compounds that extend life span in model organisms, clinical trials of therapeutics that target aging processes remain scarce. Progress in aging research is hindered by barriers associated with the translation of basic science discoveries into the clinic. This report summarizes discussions held at a 2014 Geroscience Network retreat focused on identifying hurdles that currently impede the preclinical development of drugs targeting fundamental aging processes. From these discussions, it was evident that aging researchers have varied perceptions of the ideal preclinical pipeline. To forge a clear and cohesive path forward, several areas of controversy must first be resolved and new tools developed. Here, we focus on five key issues in preclinical drug development (drug discovery, lead compound development, translational preclinical biomarkers, funding, and integration between researchers and clinicians), expanding upon discussions held at the Geroscience Retreat and suggesting areas for further research. By bringing these findings to the attention of the aging research community, we hope to lay the foundation for a concerted preclinical drug development pipeline. © The Author 2016. Published by Oxford University Press on behalf of The Gerontological Society of America.

Pharmaceutical cocrystals: along the path to improved medicines.

PubMed

Duggirala, Naga K; Perry, Miranda L; Almarsson, Örn; Zaworotko, Michael J

2016-01-14

Cocrystals, a long known but understudied class of crystalline solids, have attracted interest from crystal engineers and pharmaceutical scientists in the past decade and are now an integral part of the preformulation stage of drug development. This is largely because cocrystals that contain a drug molecule, pharmaceutical cocrystals, can modify physicochemical properties without the need for covalent modification of the drug molecule. This review presents a brief history of cocrystals before addressing recent advances in design, discovery and development of pharmaceutical cocrystals that have occurred since an earlier review published in 2004. We address four aspects of cocrystals: nomenclature; design using hydrogen-bonded supramolecular synthons; methods of discovery and synthesis; development of pharmaceutical cocrystals as drug products. Cocrystals can be classified into molecular cocrystals (MCCs) that contain only neutral components (coformers) and ionic cocrystals (ICCs), which are comprised of at least one ionic coformer that is a salt. That cocrystals, especially ICCs, offer much greater diversity in terms of composition and properties than single component crystal forms and are amenable to design makes them of continuing interest. Seven recent case studies that illustrate how pharmaceutical cocrystals can improve physicochemical properties and clinical performance of drug substances, including a recently approved drug product based upon an ICC, are presented.

2014 Edition Release 2 Electronic Health Record (EHR) certification criteria and the ONC HIT Certification Program; regulatory flexibilities, improvements, and enhanced health information exchange. Final rule.

PubMed

2014-09-11

This final rule introduces regulatory flexibilities and general improvements for certification to the 2014 Edition EHR certification criteria (2014 Edition). It also codifies a few revisions and updates to the ONC HIT Certification Program for certification to the 2014 Edition and future editions of certification criteria as well as makes administrative updates to the Code of Federal Regulations.

Looking for Skeletons in the Data Centre `Cupboard': How Repository Certification Can Help

NASA Astrophysics Data System (ADS)

Sorvari, S.; Glaves, H.

2017-12-01

There has been a national geoscience repository at the British Geological Survey (or one of its previous incarnations) almost since its inception in 1835. This longevity has resulted in vast amounts of analogue material and, more recently, digital data some of which has been collected by our scientists but much more has been acquired either through various legislative obligations or donated from various sources. However, the role and operation of the UK National Geoscience Data Centre (NGDC) in the 21st Century is very different to that of the past, with new systems and procedures dealing with predominantly digital data. A web-based ingestion portal allows users to submit their data directly to the NGDC while online services provide discovery and access to data and derived products. Increasingly we are also required to implement an array of standards e.g. ISO, OGC, W3C, best practices e.g. FAIR and legislation e.g. EU INSPIRE Directive; whilst at the same time needing to justifying our very existence to our funding agency and hosting organisation. External pressures to demonstrate that we can be recognised as a trusted repository by researchers, various funding agencies, publishers and other related entities have forced us to look at how we function, and to benchmark our operations against those of other organisations and current relevant standards such as those laid down by different repository certification processes. Following an assessment of the various options, the WDS/DSA certification process was selected as the most appropriate route for accreditation of NGDC as a trustworthy repository. It provided a suitable framework for reviewing the current systems, procedures and best practices. Undertaking this process allowed us to identify where the NGDC already has robust systems in place and where there were gaps and deficiencies in current practices. The WDS/DSA assessment process also helped to reinforce best practice throughout the NGDC and demonstrated that many of the recognised and required procedures and standards for recognition as a trusted repository were already in place, even if they were not always followed!

8 CFR 214.4 - Denial of certification, denial of recertification or withdrawal of SEVP certification.

Code of Federal Regulations, 2010 CFR

2010-01-01

... school will be notified of the reasons and appeal rights if a petition for certification is denied, in... certification. A petitioning school denied certification may file a new petition for certification at any time. (2) Denial of recertification or withdrawal on notice. The school must wait at least one calendar...

14 CFR 61.403 - What are the age, language, and pilot certificate requirements for a flight instructor...

Code of Federal Regulations, 2012 CFR

2012-01-01

... certificate requirements for a flight instructor certificate with a sport pilot rating? 61.403 Section 61.403... CERTIFICATION: PILOTS, FLIGHT INSTRUCTORS, AND GROUND INSTRUCTORS Flight Instructors With a Sport Pilot Rating... certificate with a sport pilot rating? To be eligible for a flight instructor certificate with a sport pilot...

14 CFR 61.403 - What are the age, language, and pilot certificate requirements for a flight instructor...

Code of Federal Regulations, 2013 CFR

2013-01-01

... certificate requirements for a flight instructor certificate with a sport pilot rating? 61.403 Section 61.403... CERTIFICATION: PILOTS, FLIGHT INSTRUCTORS, AND GROUND INSTRUCTORS Flight Instructors With a Sport Pilot Rating... certificate with a sport pilot rating? To be eligible for a flight instructor certificate with a sport pilot...

14 CFR 61.403 - What are the age, language, and pilot certificate requirements for a flight instructor...

Code of Federal Regulations, 2014 CFR

2014-01-01

... certificate requirements for a flight instructor certificate with a sport pilot rating? 61.403 Section 61.403... CERTIFICATION: PILOTS, FLIGHT INSTRUCTORS, AND GROUND INSTRUCTORS Flight Instructors With a Sport Pilot Rating... certificate with a sport pilot rating? To be eligible for a flight instructor certificate with a sport pilot...

46 CFR 31.40-5 - Cargo Ship Safety Construction Certificate-T/ALL.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 1 2010-10-01 2010-10-01 false Cargo Ship Safety Construction Certificate-T/ALL. 31.40... CERTIFICATION Certificates Under International Convention for Safety of Life at Sea, 1974 § 31.40-5 Cargo Ship... a Cargo Ship Safety Construction Certificate. This certificate shall be issued by the U.S. Coast...

46 CFR 31.40-5 - Cargo Ship Safety Construction Certificate-T/ALL.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 1 2011-10-01 2011-10-01 false Cargo Ship Safety Construction Certificate-T/ALL. 31.40... CERTIFICATION Certificates Under International Convention for Safety of Life at Sea, 1974 § 31.40-5 Cargo Ship... a Cargo Ship Safety Construction Certificate. This certificate shall be issued by the U.S. Coast...

46 CFR 31.40-5 - Cargo Ship Safety Construction Certificate-T/ALL.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 1 2013-10-01 2013-10-01 false Cargo Ship Safety Construction Certificate-T/ALL. 31.40... CERTIFICATION Certificates Under International Convention for Safety of Life at Sea, 1974 § 31.40-5 Cargo Ship... a Cargo Ship Safety Construction Certificate. This certificate shall be issued by the U.S. Coast...

46 CFR 31.40-5 - Cargo Ship Safety Construction Certificate-T/ALL.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 1 2014-10-01 2014-10-01 false Cargo Ship Safety Construction Certificate-T/ALL. 31.40... CERTIFICATION Certificates Under International Convention for Safety of Life at Sea, 1974 § 31.40-5 Cargo Ship... a Cargo Ship Safety Construction Certificate. This certificate shall be issued by the U.S. Coast...

46 CFR 31.40-5 - Cargo Ship Safety Construction Certificate-T/ALL.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 1 2012-10-01 2012-10-01 false Cargo Ship Safety Construction Certificate-T/ALL. 31.40... CERTIFICATION Certificates Under International Convention for Safety of Life at Sea, 1974 § 31.40-5 Cargo Ship... a Cargo Ship Safety Construction Certificate. This certificate shall be issued by the U.S. Coast...

14 CFR 61.403 - What are the age, language, and pilot certificate requirements for a flight instructor...

Code of Federal Regulations, 2011 CFR

2011-01-01

... certificate requirements for a flight instructor certificate with a sport pilot rating? 61.403 Section 61.403... CERTIFICATION: PILOTS, FLIGHT INSTRUCTORS, AND GROUND INSTRUCTORS Flight Instructors With a Sport Pilot Rating... certificate with a sport pilot rating? To be eligible for a flight instructor certificate with a sport pilot...

14 CFR 61.403 - What are the age, language, and pilot certificate requirements for a flight instructor...

Code of Federal Regulations, 2010 CFR

2010-01-01

... certificate requirements for a flight instructor certificate with a sport pilot rating? 61.403 Section 61.403... CERTIFICATION: PILOTS, FLIGHT INSTRUCTORS, AND GROUND INSTRUCTORS Flight Instructors With a Sport Pilot Rating... certificate with a sport pilot rating? To be eligible for a flight instructor certificate with a sport pilot...

42 CFR 493.1775 - Standard: Inspection of laboratories issued a certificate of waiver or a certificate for provider...

Code of Federal Regulations, 2010 CFR

2010-10-01

... certificate of waiver or a certificate for provider-performed microscopy procedures. 493.1775 Section 493.1775... laboratories issued a certificate of waiver or a certificate for provider-performed microscopy procedures. (a... microscopy procedures is not subject to biennial inspections. (b) If necessary, CMS or a CMS agent may...

42 CFR 493.1775 - Standard: Inspection of laboratories issued a certificate of waiver or a certificate for provider...

Code of Federal Regulations, 2011 CFR

2011-10-01

... certificate of waiver or a certificate for provider-performed microscopy procedures. 493.1775 Section 493.1775... laboratories issued a certificate of waiver or a certificate for provider-performed microscopy procedures. (a... microscopy procedures is not subject to biennial inspections. (b) If necessary, CMS or a CMS agent may...

42 CFR 493.1775 - Standard: Inspection of laboratories issued a certificate of waiver or a certificate for provider...

Code of Federal Regulations, 2014 CFR

2014-10-01

... certificate of waiver or a certificate for provider-performed microscopy procedures. 493.1775 Section 493.1775... laboratories issued a certificate of waiver or a certificate for provider-performed microscopy procedures. (a... microscopy procedures is not subject to biennial inspections. (b) If necessary, CMS or a CMS agent may...

42 CFR 493.1775 - Standard: Inspection of laboratories issued a certificate of waiver or a certificate for provider...

Code of Federal Regulations, 2013 CFR

2013-10-01

... certificate of waiver or a certificate for provider-performed microscopy procedures. 493.1775 Section 493.1775... laboratories issued a certificate of waiver or a certificate for provider-performed microscopy procedures. (a... microscopy procedures is not subject to biennial inspections. (b) If necessary, CMS or a CMS agent may...

42 CFR 493.1775 - Standard: Inspection of laboratories issued a certificate of waiver or a certificate for provider...

Code of Federal Regulations, 2012 CFR

2012-10-01

... certificate of waiver or a certificate for provider-performed microscopy procedures. 493.1775 Section 493.1775... laboratories issued a certificate of waiver or a certificate for provider-performed microscopy procedures. (a... microscopy procedures is not subject to biennial inspections. (b) If necessary, CMS or a CMS agent may...

78 FR 42678 - Certification of Factual Information To Import Administration During Antidumping and...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-17

...The Department of Commerce (``the Department'') is amending the regulation which governs the certification of factual information submitted to the Department by a person or his or her representative during antidumping (``AD'') and countervailing duty (``CVD'') proceedings. The amended regulation is intended to strengthen the current certification requirements. For example, the amendment revises the certification in order to identify to which document the certification applies, to identify to which segment of an AD/CVD proceeding the certification applies, to identify who is making the certification, and to indicate the date on which the certification was made. In addition, the amendments are intended to ensure that parties and their counsel are aware of potential consequences for false certifications.

Solving Hard Computational Problems Efficiently: Asymptotic Parametric Complexity 3-Coloring Algorithm

PubMed Central

Martín H., José Antonio

2013-01-01

Many practical problems in almost all scientific and technological disciplines have been classified as computationally hard (NP-hard or even NP-complete). In life sciences, combinatorial optimization problems frequently arise in molecular biology, e.g., genome sequencing; global alignment of multiple genomes; identifying siblings or discovery of dysregulated pathways. In almost all of these problems, there is the need for proving a hypothesis about certain property of an object that can be present if and only if it adopts some particular admissible structure (an NP-certificate) or be absent (no admissible structure), however, none of the standard approaches can discard the hypothesis when no solution can be found, since none can provide a proof that there is no admissible structure. This article presents an algorithm that introduces a novel type of solution method to “efficiently” solve the graph 3-coloring problem; an NP-complete problem. The proposed method provides certificates (proofs) in both cases: present or absent, so it is possible to accept or reject the hypothesis on the basis of a rigorous proof. It provides exact solutions and is polynomial-time (i.e., efficient) however parametric. The only requirement is sufficient computational power, which is controlled by the parameter . Nevertheless, here it is proved that the probability of requiring a value of to obtain a solution for a random graph decreases exponentially: , making tractable almost all problem instances. Thorough experimental analyses were performed. The algorithm was tested on random graphs, planar graphs and 4-regular planar graphs. The obtained experimental results are in accordance with the theoretical expected results. PMID:23349711

Greater than the sum of its parts: single-nucleus sequencing identifies convergent evolution of independent EGFR mutants in GBM.

PubMed

Gini, Beatrice; Mischel, Paul S

2014-08-01

Single-cell sequencing approaches are needed to characterize the genomic diversity of complex tumors, shedding light on their evolutionary paths and potentially suggesting more effective therapies. In this issue of Cancer Discovery, Francis and colleagues develop a novel integrative approach to identify distinct tumor subpopulations based on joint detection of clonal and subclonal events from bulk tumor and single-nucleus whole-genome sequencing, allowing them to infer a subclonal architecture. Surprisingly, the authors identify convergent evolution of multiple, mutually exclusive, independent EGFR gain-of-function variants in a single tumor. This study demonstrates the value of integrative single-cell genomics and highlights the biologic primacy of EGFR as an actionable target in glioblastoma. ©2014 American Association for Cancer Research.

From the GKLS Equation to the Theory of Solar and Fuel Cells

NASA Astrophysics Data System (ADS)

Alicki, R.

The mathematically sound theory of quantum open systems, formulated in the ’70s and highlighted by the discovery of Gorini-Kossakowski-Lindblad-Sudarshan (GKLS) equation, found a wide range of applications in various branches of physics and chemistry, notably in the field of quantum information and quantum thermodynamics. However, it took 40 years before this formalism has been applied to explain correctly the operation principles of long existing energy transducers like photovoltaic, thermoelectric and fuel cells. This long path is briefly reviewed from the author’s perspective. Finally, the new, fully quantum model of chemical engine based on GKLS equation and applicable to fuel cells or replicators is outlined. The model illustrates the difficulty with an entirely quantum operational definition of work, comparable to the problem of quantum measurement.

Vesper - Venus Chemistry and Dynamics Orbiter - A NASA Discovery Mission Proposal: Submillimeter Investigation of Atmospheric Chemistry and Dynamics

NASA Technical Reports Server (NTRS)

Chin, Gordon

2011-01-01

Vesper conducts a focused investigation of the chemistry and dynamics of the middle atmosphere of our sister planet- from the base of the global cloud cover to the lower thermosphere. The middle atmosphere controls the stability of the Venus climate system. Vesper determines what processes maintain the atmospheric chemical stability, cause observed variability of chemical composition, control the escape of water, and drive the extreme super-rotation. The Vesper science investigation provides a unique perspective on the Earth environment due to the similarities in the middle atmosphere processes of both Venus and the Earth. Understanding key distinctions and similarities between Venus and Earth will increase our knowledge of how terrestrial planets evolve along different paths from nearly identical initial conditions.

The path to next generation biofuels: successes and challenges in the era of synthetic biology

PubMed Central

2010-01-01

Volatility of oil prices along with major concerns about climate change, oil supply security and depleting reserves have sparked renewed interest in the production of fuels from renewable resources. Recent advances in synthetic biology provide new tools for metabolic engineers to direct their strategies and construct optimal biocatalysts for the sustainable production of biofuels. Metabolic engineering and synthetic biology efforts entailing the engineering of native and de novo pathways for conversion of biomass constituents to short-chain alcohols and advanced biofuels are herewith reviewed. In the foreseeable future, formal integration of functional genomics and systems biology with synthetic biology and metabolic engineering will undoubtedly support the discovery, characterization, and engineering of new metabolic routes and more efficient microbial systems for the production of biofuels. PMID:20089184

Vicarious trial and error

PubMed Central

Redish, A. David

2016-01-01

When rats come to a decision point, they sometimes pause and look back and forth as if deliberating over the choice; at other times, they proceed as if they have already made their decision. In the 1930s, this pause-and-look behaviour was termed ‘vicarious trial and error’ (VTE), with the implication that the rat was ‘thinking about the future’. The discovery in 2007 that the firing of hippocampal place cells gives rise to alternating representations of each of the potential path options in a serial manner during VTE suggested a possible neural mechanism that could underlie the representations of future outcomes. More-recent experiments examining VTE in rats suggest that there are direct parallels to human processes of deliberative decision making, working memory and mental time travel. PMID:26891625

Lighting a path: genetic studies pinpoint neurodevelopmental mechanisms in autism and related disorders.

PubMed

Pescosolido, Matthew F; Yang, Unikora; Sabbagh, Mark; Morrow, Eric M

2012-09-01

In this review, we outline critical molecular processes that have been implicated by discovery of genetic mutations in autism. These mechanisms need to be mapped onto the neurodevelopment step(s) gone awry that may be associated with cause in autism. Molecular mechanisms include: (i) regulation of gene expression; (ii) pre-mRNA splicing; (iii) protein localization, translation, and turnover; (iv) synaptic transmission; (v) cell signaling; (vi) the functions of cytoskeletal and scaffolding proteins; and (vii) the function of neuronal cell adhesion molecules. While the molecular mechanisms appear broad, they may converge on only one of a few steps during neurodevelopment that perturbs the structure, function, and/or plasticity of neuronal circuitry. While there are many genetic mutations involved, novel treatments may need to target only one of few developmental mechanisms.

Big Data: Next-Generation Machines for Big Science

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hack, James J.; Papka, Michael E.

Addressing the scientific grand challenges identified by the US Department of Energy’s (DOE’s) Office of Science’s programs alone demands a total leadership-class computing capability of 150 to 400 Pflops by the end of this decade. The successors to three of the DOE’s most powerful leadership-class machines are set to arrive in 2017 and 2018—the products of the Collaboration Oak Ridge Argonne Livermore (CORAL) initiative, a national laboratory–industry design/build approach to engineering nextgeneration petascale computers for grand challenge science. These mission-critical machines will enable discoveries in key scientific fields such as energy, biotechnology, nanotechnology, materials science, and high-performance computing, and servemore » as a milestone on the path to deploying exascale computing capabilities.« less

DISCOVERY OF A PSEUDOBULGE GALAXY LAUNCHING POWERFUL RELATIVISTIC JETS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kotilainen, Jari K.; Olguín-Iglesias, Alejandro; León-Tavares, Jonathan

Supermassive black holes launching plasma jets at close to the speed of light, producing gamma-rays, have ubiquitously been found to be hosted by massive elliptical galaxies. Since elliptical galaxies are generally believed to be built through galaxy mergers, active galactic nuclei (AGN) launching relativistic jets are associated with the latest stages of galaxy evolution. We have discovered a pseudobulge morphology in the host galaxy of the gamma-ray AGN PKS 2004-447. This is the first gamma-ray emitter radio-loud AGN found to have been launched from a system where both the black hole and host galaxy have been actively growing via secularmore » processes. This is evidence of an alternative black hole–galaxy co-evolutionary path to develop powerful relativistic jets, which is not merger driven.« less

The origin of scientific neurology and its consequences for modern and future neuroscience.

PubMed

Steinberg, David A

2014-01-01

John Hughlings Jackson (1835-1911) created a science of brain function that, in scope and profundity, is among the great scientific discoveries of the 19th century. It is interesting that the magnitude of his achievement is not completely recognized even among his ardent admirers. Although thousands of practitioners around the world use the clinical applications of his science every day, the principles from which bedside neurology is derived have broader consequences-for modern and future science-that remain unrecognized and unexploited. This paper summarizes the scientific formalism that created modern neurology, demonstrates how its direct implications affect a current area of neuroscientific research, and indicates how Hughlings Jackson's ideas form a path toward a novel solution to an important open problem of the brain and mind.

The International Space Station: A National Science Laboratory

NASA Technical Reports Server (NTRS)

Giblin, Timothy W.

2011-01-01

After more than a decade of assembly missions and on the heels of the final voyage of Space Shuttle Discovery, the International Space Station (ISS) has reached assembly completion. With visiting spacecraft now docking with the ISS on a regular basis, the Station now serves as a National Laboratory to scientists back on Earth. ISS strengthens relationships among NASA, other Federal entities, higher educational institutions, and the private sector in the pursuit of national priorities for the advancement of science, technology, engineering, and mathematics. In this lecture we will explore the various areas of research onboard ISS to promote this advancement: (1) Human Research, (2) Biology & Biotechnology, (3) Physical & Material Sciences, (4) Technology, and (5) Earth & Space Science. The ISS National Laboratory will also open new paths for the exploration and economic development of space.

13 CFR 127.301 - When may a contracting officer accept a concern's self-certification?

Code of Federal Regulations, 2014 CFR

2014-01-01

...) Third-Party Certifications. A contracting officer may accept a concern's self-certification in SAM (or...) Non-Third Party Certification. A contracting officer may accept a concern's self-certification in SAM...

15 CFR 996.22 - Certification.

Code of Federal Regulations, 2014 CFR

2014-01-01

... REQUIREMENTS FOR NOAA HYDROGRAPHIC PRODUCTS AND SERVICES QUALITY ASSURANCE AND CERTIFICATION REQUIREMENTS FOR NOAA HYDROGRAPHIC PRODUCTS AND SERVICES Certification of a Hydrographic Product and Decertification... automatically be considered for certification by NOAA. NOAA shall make its certification determination, if its...

15 CFR 996.22 - Certification.

Code of Federal Regulations, 2012 CFR

2012-01-01

... REQUIREMENTS FOR NOAA HYDROGRAPHIC PRODUCTS AND SERVICES QUALITY ASSURANCE AND CERTIFICATION REQUIREMENTS FOR NOAA HYDROGRAPHIC PRODUCTS AND SERVICES Certification of a Hydrographic Product and Decertification... automatically be considered for certification by NOAA. NOAA shall make its certification determination, if its...

15 CFR 996.22 - Certification.

Code of Federal Regulations, 2013 CFR

2013-01-01

... REQUIREMENTS FOR NOAA HYDROGRAPHIC PRODUCTS AND SERVICES QUALITY ASSURANCE AND CERTIFICATION REQUIREMENTS FOR NOAA HYDROGRAPHIC PRODUCTS AND SERVICES Certification of a Hydrographic Product and Decertification... automatically be considered for certification by NOAA. NOAA shall make its certification determination, if its...

15 CFR 996.22 - Certification.

Code of Federal Regulations, 2011 CFR

2011-01-01

... REQUIREMENTS FOR NOAA HYDROGRAPHIC PRODUCTS AND SERVICES QUALITY ASSURANCE AND CERTIFICATION REQUIREMENTS FOR NOAA HYDROGRAPHIC PRODUCTS AND SERVICES Certification of a Hydrographic Product and Decertification... automatically be considered for certification by NOAA. NOAA shall make its certification determination, if its...

13 CFR 127.301 - When may a contracting officer accept a concern's self-certification?

Code of Federal Regulations, 2013 CFR

2013-01-01

...) Third-Party Certifications. A contracting officer may accept a concern's self-certification on ORCA as... Certification. A contracting officer may accept a concern's self-certification in ORCA if the apparent...

13 CFR 127.301 - When may a contracting officer accept a concern's self-certification?

Code of Federal Regulations, 2012 CFR

2012-01-01

...) Third-Party Certifications. A contracting officer may accept a concern's self-certification on ORCA as... Certification. A contracting officer may accept a concern's self-certification in ORCA if the apparent...

45 CFR 170.557 - Authorized certification methods.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 170.557 Public Welfare Department of Health and Human Services HEALTH INFORMATION TECHNOLOGY HEALTH INFORMATION TECHNOLOGY STANDARDS, IMPLEMENTATION SPECIFICATIONS, AND CERTIFICATION CRITERIA AND CERTIFICATION PROGRAMS FOR HEALTH INFORMATION TECHNOLOGY ONC HIT Certification Program § 170.557 Authorized certification...

45 CFR 170.557 - Authorized certification methods.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 170.557 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH INFORMATION TECHNOLOGY HEALTH INFORMATION TECHNOLOGY STANDARDS, IMPLEMENTATION SPECIFICATIONS, AND CERTIFICATION CRITERIA AND CERTIFICATION PROGRAMS FOR HEALTH INFORMATION TECHNOLOGY ONC HIT Certification Program § 170.557 Authorized certification...

45 CFR 170.550 - EHR Module certification.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH INFORMATION TECHNOLOGY HEALTH INFORMATION TECHNOLOGY STANDARDS, IMPLEMENTATION SPECIFICATIONS, AND CERTIFICATION CRITERIA AND CERTIFICATION PROGRAMS FOR HEALTH INFORMATION TECHNOLOGY ONC HIT Certification Program § 170.550 EHR Module certification. (a...

45 CFR 170.510 - Types of certification.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH INFORMATION TECHNOLOGY HEALTH INFORMATION TECHNOLOGY STANDARDS, IMPLEMENTATION SPECIFICATIONS, AND CERTIFICATION CRITERIA AND CERTIFICATION PROGRAMS FOR HEALTH INFORMATION TECHNOLOGY ONC HIT Certification Program § 170.510 Types of certification...

45 CFR 170.550 - EHR Module certification.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Public Welfare Department of Health and Human Services HEALTH INFORMATION TECHNOLOGY HEALTH INFORMATION TECHNOLOGY STANDARDS, IMPLEMENTATION SPECIFICATIONS, AND CERTIFICATION CRITERIA AND CERTIFICATION PROGRAMS FOR HEALTH INFORMATION TECHNOLOGY ONC HIT Certification Program § 170.550 EHR Module certification...

45 CFR 170.510 - Types of certification.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Public Welfare Department of Health and Human Services HEALTH INFORMATION TECHNOLOGY HEALTH INFORMATION TECHNOLOGY STANDARDS, IMPLEMENTATION SPECIFICATIONS, AND CERTIFICATION CRITERIA AND CERTIFICATION PROGRAMS FOR HEALTH INFORMATION TECHNOLOGY ONC HIT Certification Program § 170.510 Types of certification...

A machine-learned computational functional genomics-based approach to drug classification.

PubMed

Lötsch, Jörn; Ultsch, Alfred

2016-12-01

The public accessibility of "big data" about the molecular targets of drugs and the biological functions of genes allows novel data science-based approaches to pharmacology that link drugs directly with their effects on pathophysiologic processes. This provides a phenotypic path to drug discovery and repurposing. This paper compares the performance of a functional genomics-based criterion to the traditional drug target-based classification. Knowledge discovery in the DrugBank and Gene Ontology databases allowed the construction of a "drug target versus biological process" matrix as a combination of "drug versus genes" and "genes versus biological processes" matrices. As a canonical example, such matrices were constructed for classical analgesic drugs. These matrices were projected onto a toroid grid of 50 × 82 artificial neurons using a self-organizing map (SOM). The distance, respectively, cluster structure of the high-dimensional feature space of the matrices was visualized on top of this SOM using a U-matrix. The cluster structure emerging on the U-matrix provided a correct classification of the analgesics into two main classes of opioid and non-opioid analgesics. The classification was flawless with both the functional genomics and the traditional target-based criterion. The functional genomics approach inherently included the drugs' modulatory effects on biological processes. The main pharmacological actions known from pharmacological science were captures, e.g., actions on lipid signaling for non-opioid analgesics that comprised many NSAIDs and actions on neuronal signal transmission for opioid analgesics. Using machine-learned techniques for computational drug classification in a comparative assessment, a functional genomics-based criterion was found to be similarly suitable for drug classification as the traditional target-based criterion. This supports a utility of functional genomics-based approaches to computational system pharmacology for drug discovery and repurposing.

The Discovery of the Electromagnetic Counterpart of GW170817: Kilonova AT 2017gfo/DLT17ck

DOE Office of Scientific and Technical Information (OSTI.GOV)

Valenti, Stefano; Yang, Sheng; Tartaglia, Leonardo

During the second observing run of the Laser Interferometer Gravitational-wave Observatory (LIGO) and Virgo Interferometer, a gravitational-wave signal consistent with a binary neutron star coalescence was detected on 2017 August 17th (GW170817), quickly followed by a coincident short gamma-ray burst trigger detected by the Fermi satellite. The Distance Less Than 40 (DLT40) Mpc supernova search performed pointed follow-up observations of a sample of galaxies regularly monitored by the survey that fell within the combined LIGO+Virgo localization region and the larger Fermi gamma-ray burst error box. Here we report the discovery of a new optical transient (DLT17ck, also known as SSS17a;more » it has also been registered as AT 2017gfo) spatially and temporally coincident with GW170817. The photometric and spectroscopic evolution of DLT17ck is unique, with an absolute peak magnitude of M {sub r} = −15.8 ± 0.1 and an r -band decline rate of 1.1 mag day{sup −1}. This fast evolution is generically consistent with kilonova models, which have been predicted as the optical counterpart to binary neutron star coalescences. Analysis of archival DLT40 data does not show any sign of transient activity at the location of DLT17ck down to r ∼ 19 mag in the time period between 8 months and 21 days prior to GW170817. This discovery represents the beginning of a new era for multi-messenger astronomy, opening a new path by which to study and understand binary neutron star coalescences, short gamma-ray bursts, and their optical counterparts.« less

Pheochromocytoma and paraganglioma

PubMed Central

Kantorovich, Vitaly; Pacak, Karel

2016-01-01

Pheochromocytoma is a very special kind of tumor full of duplicity. On the one hand it represents its own microworld with unique clinical, biochemical and pathological features, while on the other it constitutes a tremendously significant part of whole body system, playing a vital role for practically every organ system. It has a very special character – sometimes like a child it can be sweet and predictable, while at times it can behave like a deadly wild beast, crashing and tearing everything on its path in a fierce rage. It also consists of the amazingly intelligent neuroendocrine cells that possess a magical ability to make miraculous substances of many kinds. But most of all, it is a system that is able to drive our curiosity and the itch of “Cogito, ergo sum” to limitless depths and year by year it still amazes us with new and unexpected discoveries that move our understanding of multiple pathways and metabolic events closer to the ultimate truth. Recent discoveries of succinate dehydrogenase (SHD) and prolyl hydroxylase (PHD) mutations, for example, propelled our understanding of neuroendocrine tumorigenesis as a whole, as well as physiology of mitochondrial respiratory chain and phenomenon of pseudohypoxia in particular. Good old discoveries make their way from dusty repositories to shine with new meaning, appropriate for the current level of knowledge. This acquired wisdom makes us better physicians – knowing the specific expression makeup of catecholamine transporters, GLUTs and SRIFs allows for better tailored imaging and therapeutic manipulations. There are still long ways to go, keeping in mind that pheochromocytoma is but so very special, and we are optimistic and expect many great things to come. PMID:20541673

Gaze training enhances laparoscopic technical skill acquisition and multi-tasking performance: a randomized, controlled study.

PubMed

Wilson, Mark R; Vine, Samuel J; Bright, Elizabeth; Masters, Rich S W; Defriend, David; McGrath, John S

2011-12-01

The operating room environment is replete with stressors and distractions that increase the attention demands of what are already complex psychomotor procedures. Contemporary research in other fields (e.g., sport) has revealed that gaze training interventions may support the development of robust movement skills. This current study was designed to examine the utility of gaze training for technical laparoscopic skills and to test performance under multitasking conditions. Thirty medical trainees with no laparoscopic experience were divided randomly into one of three treatment groups: gaze trained (GAZE), movement trained (MOVE), and discovery learning/control (DISCOVERY). Participants were fitted with a Mobile Eye gaze registration system, which measures eye-line of gaze at 25 Hz. Training consisted of ten repetitions of the "eye-hand coordination" task from the LAP Mentor VR laparoscopic surgical simulator while receiving instruction and video feedback (specific to each treatment condition). After training, all participants completed a control test (designed to assess learning) and a multitasking transfer test, in which they completed the procedure while performing a concurrent tone counting task. Not only did the GAZE group learn more quickly than the MOVE and DISCOVERY groups (faster completion times in the control test), but the performance difference was even more pronounced when multitasking. Differences in gaze control (target locking fixations), rather than tool movement measures (tool path length), underpinned this performance advantage for GAZE training. These results suggest that although the GAZE intervention focused on training gaze behavior only, there were indirect benefits for movement behaviors and performance efficiency. Additionally, focusing on a single external target when learning, rather than on complex movement patterns, may have freed-up attentional resources that could be applied to concurrent cognitive tasks.

Discovery and resolve: the Human Genetics Society of Australasia Oration 2011.

PubMed

Pearn, John

2011-10-01

Human genetics spans every facet of biology from molecular science, through laboratory and clinical practice, to psychology and anthropology. In each of these areas, the history of human genetics has been punctuated by paradigm shifts in knowledge. Each such new concept has been received with skepticism, often with perplexity, and sometimes with frank incredulity. Such comprise the datum milestones along the path leading to our present corpus of genetic knowledge. In parallel to the personal threats to Copernicus and Galileo in the field of astronomy in the 17th century, almost all genetic discoveries of the 19th and 20th centuries were seen as challenges to the received wisdom, and sometimes the social order, of their time and place. Researchers, scientists and clinicians encountering such new and often-heretical paradigm shifts have required considerable resolve to promote and publish their work. Just as in the field of astronomy, new directions in genetics have threatened not only the reputations and sometimes the careers of scientists, but also have been challenges to fundamental religious and sociological beliefs in society more broadly. Examples followed the discovery of biological sexual dimorphism (in plants as well as animals) by Nehemiah Grew (1641-1712). Darwinian evolution, Mendel's First and Second Laws, the existence of mitochondrial genes, apoptosis and its genetic basis, and uniparental disomy are more recent examples. Many of these new revelations, which today have led to the current understanding of fundamental biology, were discovered by individuals working in relative isolation. To promote and publish findings that fundamentally challenge received wisdom continues to require considerable resolve, if not courage. Herein lies a message for all clinicians and researchers.

7 CFR 205.404 - Granting certification.

Code of Federal Regulations, 2010 CFR

2010-01-01

... PROVISIONS NATIONAL ORGANIC PROGRAM Certification § 205.404 Granting certification. (a) Within a reasonable... certified operation; (2) Effective date of certification; (3) Categories of organic operation, including... operation's organic certification continues in effect until surrendered by the organic operation or...

Perceived value of national certification for pediatric nurses.

PubMed

Messmer, Patricia R; Hill-Rodriguez, Deborah; Williams, Arthur R; Ernst, Mary E; Tahmooressi, Jill

2011-09-01

This study evaluated whether pediatric nurses who were certified valued national certifications to a greater degree than those who were not certified. The Gaberson, Schroeter, Killen, and Valentine (2003) Perceived Value of Certification Tool (PVCT) was used to measure nurses' perceptions of certification. The PVCT includes 18 certification-related value statements, using a five-point Likert scale response ranging from strongly agree to strongly disagree. A principal factor analysis was performed to identify clusters of related variables. Certified pediatric nurses valued national certifications to a greater degree than those who were not certified. More favorable views of certification were moderately associated with favorable views of the effects of certification on salary. The PVCT was found to have one factor, not two, as previously reported in the literature. Lower perceived relationships were reported between certification and salary, clinical competence, and consumer confidence compared with feelings of professionalism and personal satisfaction. Efforts to improve the relationship between certification and its perceived value at one institution were addressed. More attention may be needed to strengthen relationships, perceived or otherwise, between certification and competency skills, public awareness, and compensation of nurses for holding national certification. Copyright 2011, SLACK Incorporated.

7 CFR 353.7 - Certificates.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 5 2012-01-01 2012-01-01 false Certificates. 353.7 Section 353.7 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE EXPORT CERTIFICATION § 353.7 Certificates. (a) Phytosanitary certificate (PPQ Form...

45 CFR 170.302 - General certification criteria for Complete EHRs or EHR Modules.

Code of Federal Regulations, 2013 CFR

2013-10-01

... INFORMATION TECHNOLOGY HEALTH INFORMATION TECHNOLOGY STANDARDS, IMPLEMENTATION SPECIFICATIONS, AND CERTIFICATION CRITERIA AND CERTIFICATION PROGRAMS FOR HEALTH INFORMATION TECHNOLOGY Certification Criteria for Health Information Technology § 170.302 General certification criteria for Complete EHRs or EHR Modules...

45 CFR 170.302 - General certification criteria for Complete EHRs or EHR Modules.

Code of Federal Regulations, 2014 CFR

2014-10-01

... INFORMATION TECHNOLOGY HEALTH INFORMATION TECHNOLOGY STANDARDS, IMPLEMENTATION SPECIFICATIONS, AND CERTIFICATION CRITERIA AND CERTIFICATION PROGRAMS FOR HEALTH INFORMATION TECHNOLOGY Certification Criteria for Health Information Technology § 170.302 General certification criteria for Complete EHRs or EHR Modules...

45 CFR 170.302 - General certification criteria for Complete EHRs or EHR Modules.

Code of Federal Regulations, 2011 CFR

2011-10-01

... INFORMATION TECHNOLOGY HEALTH INFORMATION TECHNOLOGY STANDARDS, IMPLEMENTATION SPECIFICATIONS, AND CERTIFICATION CRITERIA AND CERTIFICATION PROGRAMS FOR HEALTH INFORMATION TECHNOLOGY Certification Criteria for Health Information Technology § 170.302 General certification criteria for Complete EHRs or EHR Modules...

45 CFR 170.302 - General certification criteria for Complete EHRs or EHR Modules.

Code of Federal Regulations, 2012 CFR

2012-10-01

... INFORMATION TECHNOLOGY HEALTH INFORMATION TECHNOLOGY STANDARDS, IMPLEMENTATION SPECIFICATIONS, AND CERTIFICATION CRITERIA AND CERTIFICATION PROGRAMS FOR HEALTH INFORMATION TECHNOLOGY Certification Criteria for Health Information Technology § 170.302 General certification criteria for Complete EHRs or EHR Modules...

40 CFR 75.20 - Initial certification and recertification procedures.

Code of Federal Regulations, 2014 CFR

2014-07-01

... all applicable initial certification tests under paragraph (c) of this section are completed by the... installed, initial certification is required. (1) Notification of initial certification test dates. The...) tests. (4) Certification (or recertification) application formal approval process. The Administrator...

40 CFR 75.20 - Initial certification and recertification procedures.

Code of Federal Regulations, 2013 CFR

2013-07-01

... all applicable initial certification tests under paragraph (c) of this section are completed by the... installed, initial certification is required. (1) Notification of initial certification test dates. The...) tests. (4) Certification (or recertification) application formal approval process. The Administrator...

40 CFR 75.20 - Initial certification and recertification procedures.

Code of Federal Regulations, 2011 CFR

2011-07-01

... all applicable initial certification tests under paragraph (c) of this section are completed by the... installed, initial certification is required. (1) Notification of initial certification test dates. The...) tests. (4) Certification (or recertification) application formal approval process. The Administrator...

14 CFR 147.3 - Certificate required.

Code of Federal Regulations, 2010 CFR

2010-01-01

... OTHER CERTIFICATED AGENCIES AVIATION MAINTENANCE TECHNICIAN SCHOOLS General § 147.3 Certificate required. No person may operate as a certificated aviation maintenance technician school without, or in violation of, an aviation maintenance technician school certificate issued under this part. [Doc. No. 15196...

Certification, Re-certification and Continuing Education.

ERIC Educational Resources Information Center

Conchelos, Mary

1983-01-01

Discussion of certification for librarians notes definitions, certification program of Medical Library Association, continuing education as means of maintaining certification, and the voluntary recognition system, which encourages and supports those who participate in continuing education by setting standards for programs, objectively evaluating…

Developing an interdisciplinary certificate program in transportation planning, phase 2 : the eCertificate.

DOT National Transportation Integrated Search

2011-11-01

This proposal extends the delivery of the recently developed graduate Certificate in Transportation : Planning to a wider audience through the establishment of an Executive Certificate Program by distance : (eCertificate). While the need for an inter...

45 CFR 170.302 - General certification criteria for Complete EHRs or EHR Modules.

Code of Federal Regulations, 2010 CFR

2010-10-01

... INFORMATION TECHNOLOGY HEALTH INFORMATION TECHNOLOGY STANDARDS, IMPLEMENTATION SPECIFICATIONS, AND CERTIFICATION CRITERIA AND CERTIFICATION PROGRAMS FOR HEALTH INFORMATION TECHNOLOGY Certification Criteria for Health Information Technology § 170.302 General certification criteria for Complete EHRs or EHR Modules...

14 CFR 47.61 - Dealer's Aircraft Registration Certificates.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Dealer's Aircraft Registration Certificates... TRANSPORTATION AIRCRAFT AIRCRAFT REGISTRATION Dealers' Aircraft Registration Certificate § 47.61 Dealer's Aircraft Registration Certificates. (a) The FAA issues a Dealer's Aircraft Registration Certificate, AC...

14 CFR 47.61 - Dealer's Aircraft Registration Certificates.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 1 2013-01-01 2013-01-01 false Dealer's Aircraft Registration Certificates... TRANSPORTATION AIRCRAFT AIRCRAFT REGISTRATION Dealers' Aircraft Registration Certificate § 47.61 Dealer's Aircraft Registration Certificates. (a) The FAA issues a Dealer's Aircraft Registration Certificate, AC...

14 CFR 47.61 - Dealer's Aircraft Registration Certificates.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Dealer's Aircraft Registration Certificates... TRANSPORTATION AIRCRAFT AIRCRAFT REGISTRATION Dealers' Aircraft Registration Certificate § 47.61 Dealer's Aircraft Registration Certificates. (a) The FAA issues a Dealer's Aircraft Registration Certificate, AC...

14 CFR 47.61 - Dealer's Aircraft Registration Certificates.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 1 2012-01-01 2012-01-01 false Dealer's Aircraft Registration Certificates... TRANSPORTATION AIRCRAFT AIRCRAFT REGISTRATION Dealers' Aircraft Registration Certificate § 47.61 Dealer's Aircraft Registration Certificates. (a) The FAA issues a Dealer's Aircraft Registration Certificate, AC...

14 CFR 47.61 - Dealers' Aircraft Registration Certificates.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Dealers' Aircraft Registration Certificates... TRANSPORTATION AIRCRAFT AIRCRAFT REGISTRATION Dealers' Aircraft Registration Certificate § 47.61 Dealers' Aircraft Registration Certificates. (a) The FAA issues a Dealers' Aircraft Registration Certificate, AC...

Acoustic flight tests of rotorcraft noise-abatement approaches using local differential GPS guidance

NASA Technical Reports Server (NTRS)

Chen, Robert T. N.; Hindson, William S.; Mueller, Arnold W.

1995-01-01

This paper presents the test design, instrumentation set-up, data acquisition, and the results of an acoustic flight experiment to study how noise due to blade-vortex interaction (BVI) may be alleviated. The flight experiment was conducted using the NASA/Army Rotorcraft Aircrew Systems Concepts Airborne Laboratory (RASCAL) research helicopter. A Local Differential Global Positioning System (LDGPS) was used for precision navigation and cockpit display guidance. A laser-based rotor state measurement system on board the aircraft was used to measure the main rotor tip-path-plane angle-of-attack. Tests were performed at Crows Landing Airfield in northern California with an array of microphones similar to that used in the standard ICAO/FAA noise certification test. The methodology used in the design of a RASCAL-specific, multi-segment, decelerating approach profile for BVI noise abatement is described, and the flight data pertaining to the flight technical errors and the acoustic data for assessing the noise reduction effectiveness are reported.

Used fuel extended storage security and safeguards by design roadmap

DOE Office of Scientific and Technical Information (OSTI.GOV)

Durbin, Samuel G.; Lindgren, Eric Richard; Jones, Robert

2016-05-01

In the United States, spent nuclear fuel (SNF) is safely and securely stored in spent fuel pools and dry storage casks. The available capacity in spent fuel pools across the nuclear fleet has nearly reached a steady state value. The excess SNF continues to be loaded in dry storage casks. Fuel is expected to remain in dry storage for periods beyond the initial dry cask certification period of 20 years. Recent licensing renewals have approved an additional 40 years. This report identifies the current requirements and evaluation techniques associated with the safeguards and security of SNF dry cask storage. Amore » set of knowledge gaps is identified in the current approaches. Finally, this roadmap identifies known knowledge gaps and provides a research path to deliver the tools and models needed to close the gaps and allow the optimization of the security and safeguards approaches for an interim spent fuel facility over the lifetime of the storage site.« less

Radiation Oncology Physics and Medical Physics Education

NASA Astrophysics Data System (ADS)

Bourland, Dan

2011-10-01

Medical physics, an applied field of physics, is the applications of physics in medicine. Medical physicists are essential professionals in contemporary healthcare, contributing primarily to the diagnosis and treatment of diseases through numerous inventions, advances, and improvements in medical imaging and cancer treatment. Clinical service, research, and teaching by medical physicists benefits thousands of patients and other individuals every day. This talk will cover three main topics. First, exciting current research and development areas in the medical physics sub-specialty of radiation oncology physics will be described, including advanced oncology imaging for treatment simulation, image-guided radiation therapy, and biologically-optimized radiation treatment. Challenges in patient safety in high-technology radiation treatments will be briefly reviewed. Second, the educational path to becoming a medical physicist will be reviewed, including undergraduate foundations, graduate training, residency, board certification, and career opportunities. Third, I will introduce the American Association of Physicists in Medicine (AAPM), which is the professional society that represents, advocates, and advances the field of medical physics (www.aapm.org).

Training for Leadership Roles in Academic Medicine: Opportunities for Psychologists in the AAMC LEAD Program.

PubMed

LaPaglia, Donna; Thompson, Britta; Hafler, Janet; Chauvin, Sheila

2017-06-01

Psychologists' roles within academic medicine have expanded well beyond research and scholarship. They are active as providers of patient care, medical education, and clinical supervision. Although the number of psychologists in academic health centers continues to grow, they represent a small portion of total medical school faculties. However, with the movement toward collaborative care models, emphasis on interprofessional teams, and increased emphasis on psychological science topics in medical curricula, psychologists are well-positioned to make further contributions. Another path through which psychologists can further increase their contributions and value within academic health centers is to aspire to leadership roles. This article describes the first author's reflections on her experiences in a two-year, cohort-based, educational leadership development certificate program in academic medicine. The cohort was comprised largely of physicians and basic scientists, and a small number of non-physician participants of which the first author was the only clinical psychologist. The insights gained from this experience provide recommendations for psychologists interested in leadership opportunities in academic medicine.

The Horizontal Gaze Nystagmus test: fraudulent science in the American courts.

PubMed

Booker, J L

2004-01-01

The Horizontal Gaze Nystagmus (HGN) test was conceived, developed and promulgated as a simple procedure for the determination of the blood alcohol concentration of drivers suspected of driving while intoxicated (DWI). Bypassing the usual scientific review process and touted through the good offices of the federal agency responsible for traffic safety, it was rushed into use as a law enforcement procedure, and was soon adopted and protected from scientific criticism by courts throughout the United States. In fact, research findings, training manuals and other relevant documents were often held as secrets by the state. Still, the protective certification of its practitioners and the immunity afforded by judicial notice failed to silence all the critics of this deeply flawed procedure. Responding to criticism, the sponsors of the test traveled the path documented in this paper that led from mere (if that word can ever truly apply to a matter of such gravity) carelessness in research through self-serving puffery and finally into deliberate fraud--always at the expense of the citizen accused.

Analysis of Operational Hazards and Safety Requirements for Traffic Aware Strategic Aircrew Requests (TASAR)

NASA Technical Reports Server (NTRS)

Koczo, Stefan, Jr.

2013-01-01

Safety analyses of the Traffic Aware Strategic Aircrew Requests (TASAR) Electronic Flight Bag (EFB) application are provided to establish its Failure Effects Classification which affects certification and operational approval requirements. TASAR was developed by NASA Langley Research Center to offer flight path improvement opportunities to the pilot during flight for operational benefits (e.g., reduced fuel, flight time). TASAR, using own-ship and network-enabled information concerning the flight and its environment, including weather and Air Traffic Control (ATC) system constraints, provides recommended improvements to the flight trajectory that the pilot can choose to request via Change Requests to ATC for revised clearance. This study reviews the Change Request process of requesting updates to the current clearance, examines the intended function of TASAR, and utilizes two safety assessment methods to establish the Failure Effects Classification of TASAR. Considerable attention has been given in this report to the identification of operational hazards potentially associated with TASAR.

7 CFR 205.400 - General requirements for certification.

Code of Federal Regulations, 2010 CFR

2010-01-01

...) ORGANIC FOODS PRODUCTION ACT PROVISIONS NATIONAL ORGANIC PROGRAM Certification § 205.400 General requirements for certification. A person seeking to receive or maintain organic certification under the... 7 Agriculture 3 2010-01-01 2010-01-01 false General requirements for certification. 205.400...

32 CFR 173.2 - Competitive Information Certification.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 1 2011-07-01 2011-07-01 false Competitive Information Certification. 173.2... CONTRACTING COMPETITIVE INFORMATION CERTIFICATE AND PROFIT REDUCTION CLAUSE § 173.2 Competitive Information Certification. (a) The Competitive Information Certificate is required prior to award of all competitively...

14 CFR 21.275 - Experimental certificates.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Experimental certificates. 21.275 Section... CERTIFICATION PROCEDURES FOR PRODUCTS AND PARTS Delegation Option Authorization Procedures § 21.275 Experimental certificates. (a) The manufacturer shall, before issuing an experimental certificate, obtain from the...

14 CFR 21.275 - Experimental certificates.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Experimental certificates. 21.275 Section... CERTIFICATION PROCEDURES FOR PRODUCTS AND PARTS Delegation Option Authorization Procedures § 21.275 Experimental certificates. (a) The manufacturer shall, before issuing an experimental certificate, obtain from the...

14 CFR 21.73 - Eligibility.

Code of Federal Regulations, 2010 CFR

2010-01-01

... Class II provisional type certificates, for amendments to provisional type certificates held by him, and for provisional amendments to type certificates held by him. (b) Any manufacturer of aircraft... provisional type certificates held by him, and for provisional amendments to type certificates held by him. (c...

7 CFR 75.31 - Appeal inspection certificate.

Code of Federal Regulations, 2011 CFR

2011-01-01

... AND CERTIFICATION OF QUALITY OF AGRICULTURAL AND VEGETABLE SEEDS Appeal Inspection § 75.31 Appeal... inspection certificate previously issued for the seed involved. Each appeal inspection certificate shall clearly identify the number and date of the inspection certificate which it supersedes. The superseded...

15 CFR 996.20 - Submission of a hydrographic product for certification.

Code of Federal Regulations, 2010 CFR

2010-01-01

... QUALITY ASSURANCE AND CERTIFICATION REQUIREMENTS FOR NOAA HYDROGRAPHIC PRODUCTS AND SERVICES QUALITY ASSURANCE AND CERTIFICATION REQUIREMENTS FOR NOAA HYDROGRAPHIC PRODUCTS AND SERVICES Certification of a Hydrographic Product and Decertification. § 996.20 Submission of a hydrographic product for certification. (a...

14 CFR 47.49 - Replacement of Certificate.

Code of Federal Regulations, 2011 CFR

2011-01-01

... AIRCRAFT REGISTRATION Certificates of Aircraft Registration § 47.49 Replacement of Certificate. (a) If the original Certificate of Aircraft Registration, AC Form 8050-3, is lost, stolen, or mutilated, the... owner. (b) The registered owner may request a temporary Certificate of Aircraft Registration pending...

14 CFR 47.49 - Replacement of Certificate.

Code of Federal Regulations, 2012 CFR

2012-01-01

... AIRCRAFT REGISTRATION Certificates of Aircraft Registration § 47.49 Replacement of Certificate. (a) If the original Certificate of Aircraft Registration, AC Form 8050-3, is lost, stolen, or mutilated, the... owner. (b) The registered owner may request a temporary Certificate of Aircraft Registration pending...

14 CFR 47.49 - Replacement of Certificate.

Code of Federal Regulations, 2014 CFR

2014-01-01

... AIRCRAFT REGISTRATION Certificates of Aircraft Registration § 47.49 Replacement of Certificate. (a) If the original Certificate of Aircraft Registration, AC Form 8050-3, is lost, stolen, or mutilated, the... owner. (b) The registered owner may request a temporary Certificate of Aircraft Registration pending...

14 CFR 47.49 - Replacement of Certificate.

Code of Federal Regulations, 2013 CFR

2013-01-01

... AIRCRAFT REGISTRATION Certificates of Aircraft Registration § 47.49 Replacement of Certificate. (a) If the original Certificate of Aircraft Registration, AC Form 8050-3, is lost, stolen, or mutilated, the... owner. (b) The registered owner may request a temporary Certificate of Aircraft Registration pending...

76 FR 55000 - Notice of Agricultural Management Assistance Organic Certification Cost-Share Program

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-06

...] Notice of Agricultural Management Assistance Organic Certification Cost-Share Program AGENCY... Departments of Agriculture for the Agricultural Management Assistance Organic Certification Cost-Share Program... organic certification cost-share funds. The AMS has allocated $1.5 million for this organic certification...

78 FR 36747 - Export Trade Certificate of Review

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-19

... DEPARTMENT OF COMMERCE International Trade Administration [Application No. 89-4A018] Export Trade Certificate of Review ACTION: Notice of Application to amend the Export Trade Certificate of Review Issued to... received an application to amend an Export Trade Certificate of Review (``Certificate''). This notice...

78 FR 62585 - Export Trade Certificate of Review

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-22

... DEPARTMENT OF COMMERCE International Trade Administration [Application No. 89-5A018] Export Trade Certificate of Review ACTION: Notice of Application to amend the Export Trade Certificate of Review Issued to... received an application to amend an Export Trade Certificate of Review (``Certificate''). This notice...

78 FR 30273 - Export Trade Certificate of Review

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-22

... DEPARTMENT OF COMMERCE International Trade Administration [Application No. 84-24A12] Export Trade Certificate of Review ACTION: Notice of Application to Amend the Export Trade Certificate of Review Issued to... application to amend an Export Trade Certificate of Review (``Certificate''). This notice summarizes the...

76 FR 10885 - Export Trade Certificate of Review

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-28

... DEPARTMENT OF COMMERCE International Trade Administration [Application No. 11-00001] Export Trade Certificate of Review ACTION: Notice of Application ( 11-00001) for an Export Trade Certificate of Review for... an application for an Export Trade Certificate of Review (``Certificate'') on February 3, 2011. This...

77 FR 61744 - Export Trade Certificate of Review

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-11

... DEPARTMENT OF COMMERCE International Trade Administration [Application No. 84-23A12] Export Trade Certificate of Review ACTION: Notice of application to amend the Export Trade Certificate of Review issued to... application to amend an Export Trade Certificate of Review (``Certificate''). This notice summarizes the...

16 CFR 1110.5 - Acceptable certificates.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 16 Commercial Practices 2 2011-01-01 2011-01-01 false Acceptable certificates. 1110.5 Section 1110.5 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION CONSUMER PRODUCT SAFETY ACT REGULATIONS CERTIFICATES OF COMPLIANCE § 1110.5 Acceptable certificates. A certificate that is in hard copy or electronic...

16 CFR 1110.5 - Acceptable certificates.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Acceptable certificates. 1110.5 Section 1110.5 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION CONSUMER PRODUCT SAFETY ACT REGULATIONS CERTIFICATES OF COMPLIANCE § 1110.5 Acceptable certificates. A certificate that is in hard copy or electronic...

16 CFR 1110.5 - Acceptable certificates.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 16 Commercial Practices 2 2012-01-01 2012-01-01 false Acceptable certificates. 1110.5 Section 1110.5 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION CONSUMER PRODUCT SAFETY ACT REGULATIONS CERTIFICATES OF COMPLIANCE § 1110.5 Acceptable certificates. A certificate that is in hard copy or electronic...

16 CFR 1110.5 - Acceptable certificates.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 16 Commercial Practices 2 2014-01-01 2014-01-01 false Acceptable certificates. 1110.5 Section 1110.5 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION CONSUMER PRODUCT SAFETY ACT REGULATIONS CERTIFICATES OF COMPLIANCE § 1110.5 Acceptable certificates. A certificate that is in hard copy or electronic...

20 CFR 656.16 - Labor certification applications for sheepherders.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Labor certification applications for... LABOR LABOR CERTIFICATION PROCESS FOR PERMANENT EMPLOYMENT OF ALIENS IN THE UNITED STATES Labor Certification Process § 656.16 Labor certification applications for sheepherders. (a) Filing requirements and...

46 CFR 169.215 - Certificate of inspection amendment.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 7 2011-10-01 2011-10-01 false Certificate of inspection amendment. 169.215 Section 169.215 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) NAUTICAL SCHOOLS SAILING SCHOOL VESSELS Inspection and Certification Certificate of Inspection § 169.215 Certificate of inspection...

46 CFR 169.215 - Certificate of inspection amendment.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 7 2010-10-01 2010-10-01 false Certificate of inspection amendment. 169.215 Section 169.215 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) NAUTICAL SCHOOLS SAILING SCHOOL VESSELS Inspection and Certification Certificate of Inspection § 169.215 Certificate of inspection...

14 CFR 47.71 - Duration of Certificate; change of status.

Code of Federal Regulations, 2010 CFR

2010-01-01

... TRANSPORTATION AIRCRAFT AIRCRAFT REGISTRATION Dealers' Aircraft Registration Certificate § 47.71 Duration of Certificate; change of status. (a) A Dealer's Aircraft Registration Certificate expires 1 year after the date...) The holder of a Dealer's Aircraft Registration Certificate shall immediately notify the FAA Aircraft...

Standards for Endovascular Neurosurgical Training and Certification of the Society of Korean Endovascular Neurosurgeons 2013

PubMed Central

Shin, Dong-Seong; Park, Sukh-Que; Kang, Hyun-Seung; Yoon, Seok-Mann; Cho, Jae-Hoon; Lim, Dong-Jun; Baik, Min-Woo; Kwon, O Ki

2014-01-01

The need for standard endovascular neurosurgical (ENS) training programs and certification in Korea cannot be overlooked due to the increasing number of ENS specialists and the expanding ENS field. The Society of Korean Endovascular Neurosurgeons (SKEN) Certification Committee has prepared training programs and certification since 2010, and the first certificates were issued in 2013. A task force team (TFT) was organized in August 2010 to develop training programs and certification. TFT members researched programs and systems in other countries to develop a program that best suited Korea. After 2 years, a rough draft of the ENS training and certification regulations were prepared, and the standard training program title was decided. The SKEN Certification Committee made an official announcement about the certification program in March 2013. The final certification regulations comprised three major parts: certified endovascular neurosurgeons (EN), certified ENS institutions, and certified ENS training institutions. Applications have been evaluated and the results were announced in June 2013 as follows: 126 members received EN certification and 55 hospitals became ENS-certified institutions. The SKEN has established standard ENS training programs together with a certification system, and it is expected that they will advance the field of ENS to enhance public health and safety in Korea. PMID:24851145

Death Certification Errors and the Effect on Mortality Statistics.

PubMed

McGivern, Lauri; Shulman, Leanne; Carney, Jan K; Shapiro, Steven; Bundock, Elizabeth

Errors in cause and manner of death on death certificates are common and affect families, mortality statistics, and public health research. The primary objective of this study was to characterize errors in the cause and manner of death on death certificates completed by non-Medical Examiners. A secondary objective was to determine the effects of errors on national mortality statistics. We retrospectively compared 601 death certificates completed between July 1, 2015, and January 31, 2016, from the Vermont Electronic Death Registration System with clinical summaries from medical records. Medical Examiners, blinded to original certificates, reviewed summaries, generated mock certificates, and compared mock certificates with original certificates. They then graded errors using a scale from 1 to 4 (higher numbers indicated increased impact on interpretation of the cause) to determine the prevalence of minor and major errors. They also compared International Classification of Diseases, 10th Revision (ICD-10) codes on original certificates with those on mock certificates. Of 601 original death certificates, 319 (53%) had errors; 305 (51%) had major errors; and 59 (10%) had minor errors. We found no significant differences by certifier type (physician vs nonphysician). We did find significant differences in major errors in place of death ( P < .001). Certificates for deaths occurring in hospitals were more likely to have major errors than certificates for deaths occurring at a private residence (59% vs 39%, P < .001). A total of 580 (93%) death certificates had a change in ICD-10 codes between the original and mock certificates, of which 348 (60%) had a change in the underlying cause-of-death code. Error rates on death certificates in Vermont are high and extend to ICD-10 coding, thereby affecting national mortality statistics. Surveillance and certifier education must expand beyond local and state efforts. Simplifying and standardizing underlying literal text for cause of death may improve accuracy, decrease coding errors, and improve national mortality statistics.