Explicit instructions and consolidation promote rewiring of automatic behaviors in the human mind.

PubMed

Szegedi-Hallgató, Emese; Janacsek, Karolina; Vékony, Teodóra; Tasi, Lia Andrea; Kerepes, Leila; Hompoth, Emőke Adrienn; Bálint, Anna; Németh, Dezső

2017-06-29

One major challenge in human behavior and brain sciences is to understand how we can rewire already existing perceptual, motor, cognitive, and social skills or habits. Here we aimed to characterize one aspect of rewiring, namely, how we can update our knowledge of sequential/statistical regularities when they change. The dynamics of rewiring was explored from learning to consolidation using a unique experimental design which is suitable to capture the effect of implicit and explicit processing and the proactive and retroactive interference. Our results indicate that humans can rewire their knowledge of such regularities incidentally, and consolidation has a critical role in this process. Moreover, old and new knowledge can coexist, leading to effective adaptivity of the human mind in the changing environment, although the execution of the recently acquired knowledge may be more fluent than the execution of the previously learned one. These findings can contribute to a better understanding of the cognitive processes underlying behavior change, and can provide insights into how we can boost behavior change in various contexts, such as sports, educational settings or psychotherapy.

Ecosystem processes and human influences regulate streamflow response to climate change at long-term ecological research sites

Treesearch

Julia A. Jones; Irena F. Creed; Kendra L. Hatcher; Robert J. Warren; Mary Beth Adams; Melinda H. Benson; Emery Boose; Warren A. Brown; John L. Campbell; Alan Covich; David W. Clow; Clifford N. Dahm; Kelly Elder; Chelcy R. Ford; Nancy B. Grimm; Donald L Henshaw; Kelli L. Larson; Evan S. Miles; Kathleen M. Miles; Stephen D. Sebestyen; Adam T. Spargo; Asa B. Stone; James M. Vose; Mark W. Williams

2012-01-01

Analyses of long-term records at 35 headwater basins in the United States and Canada indicate that climate change effects on streamflow are not as clear as might be expected, perhaps because of ecosystem processes and human influences. Evapotranspiration was higher than was predicted by temperature in water-surplus ecosystems and lower than was predicted in water-...

Integrating spatially explicit representations of landscape perceptions into land change research

USGS Publications Warehouse

Dorning, Monica; Van Berkel, Derek B.; Semmens, Darius J.

2017-01-01

Purpose of ReviewHuman perceptions of the landscape can influence land-use and land-management decisions. Recognizing the diversity of landscape perceptions across space and time is essential to understanding land change processes and emergent landscape patterns. We summarize the role of landscape perceptions in the land change process, demonstrate advances in quantifying and mapping landscape perceptions, and describe how these spatially explicit techniques have and may benefit land change research.Recent FindingsMapping landscape perceptions is becoming increasingly common, particularly in research focused on quantifying ecosystem services provision. Spatial representations of landscape perceptions, often measured in terms of landscape values and functions, provide an avenue for matching social and environmental data in land change studies. Integrating these data can provide new insights into land change processes, contribute to landscape planning strategies, and guide the design and implementation of land change models.SummaryChallenges remain in creating spatial representations of human perceptions. Maps must be accompanied by descriptions of whose perceptions are being represented and the validity and uncertainty of those representations across space. With these considerations, rapid advancements in mapping landscape perceptions hold great promise for improving representation of human dimensions in landscape ecology and land change research.

Microglia show altered morphology and reduced arborization in human brain during aging and Alzheimer's disease.

PubMed

Davies, Danielle S; Ma, Jolande; Jegathees, Thuvarahan; Goldsbury, Claire

2017-11-01

Changes in microglia function are involved in Alzheimer's disease (AD) for which ageing is the major risk factor. We evaluated microglial cell process morphologies and their gray matter coverage (arborized area) during ageing and in the presence and absence of AD pathology in autopsied human neocortex. Microglial cell processes were reduced in length, showed less branching and reduced arborized area with aging (case range 52-98 years). This occurred during normal ageing and without microglia dystrophy or changes in cell density. There was a larger reduction in process length and arborized area in AD compared to aged-matched control microglia. In AD cases, on average, 49%-64% of microglia had discontinuous and/or punctate Iba1 labeled processes instead of continuous Iba1 distribution. Up to 16% of aged-matched control microglia displayed discontinuous or punctate features. There was no change in the density of microglial cell bodies in gray matter during ageing or AD. This demonstrates that human microglia show progressive cell process retraction without cell loss during ageing. Additional changes in microglia occur with AD including Iba1 protein puncta and discontinuity. We suggest that reduced microglial arborized area may be an aging-related correlate of AD in humans. These variations in microglial cells during ageing and in AD could reflect changes in neural-glial interactions which are emerging as key to mechanisms involved in ageing and neurodegenerative disease. © 2016 International Society of Neuropathology.

Managed Relocation of Species: Noah's Ark or Pandora's Box?

NASA Astrophysics Data System (ADS)

Safford, Hugh D.; Hellmann, Jessica J.; McLachlan, Jason; Sax, Dov F.; Schwartz, Mark W.

2009-01-01

Assisted Migration: Evaluating a New Strategy for Species Conservation; Milwaukee, Wisconsin, 1-3 August 2008; The world's human population is growing rapidly. Annually we may now move more earth than natural geological processes, and our dependence on fossil fuels is causing wholesale changes in climate and many ecosystem processes. Although human impacts on the globe have long had major consequences for the Earth's other inhabitants, the current combination of massive habitat change and rapid climate change poses an especially daunting challenge for many species. Rates of anthropogenic global change, from habitat alteration to modifications of the atmosphere, are so high that many species do not possess the capacity to ``track'' these changes through natural dispersal. In addition, ``humanized'' landscapes are now so pervasive in some parts of the globe that natural dispersal corridors have all but completely disappeared.

Meta-studies in land use science: Current coverage and prospects.

PubMed

van Vliet, Jasper; Magliocca, Nicholas R; Büchner, Bianka; Cook, Elizabeth; Rey Benayas, José M; Ellis, Erle C; Heinimann, Andreas; Keys, Eric; Lee, Tien Ming; Liu, Jianguo; Mertz, Ole; Meyfroidt, Patrick; Moritz, Mark; Poeplau, Christopher; Robinson, Brian E; Seppelt, Ralf; Seto, Karen C; Verburg, Peter H

2016-02-01

Land use science has traditionally used case-study approaches for in-depth investigation of land use change processes and impacts. Meta-studies synthesize findings across case-study evidence to identify general patterns. In this paper, we provide a review of meta-studies in land use science. Various meta-studies have been conducted, which synthesize deforestation and agricultural land use change processes, while other important changes, such as urbanization, wetland conversion, and grassland dynamics have hardly been addressed. Meta-studies of land use change impacts focus mostly on biodiversity and biogeochemical cycles, while meta-studies of socioeconomic consequences are rare. Land use change processes and land use change impacts are generally addressed in isolation, while only few studies considered trajectories of drivers through changes to their impacts and their potential feedbacks. We provide a conceptual framework for linking meta-studies of land use change processes and impacts for the analysis of coupled human-environmental systems. Moreover, we provide suggestions for combining meta-studies of different land use change processes to develop a more integrated theory of land use change, and for combining meta-studies of land use change impacts to identify tradeoffs between different impacts. Land use science can benefit from an improved conceptualization of land use change processes and their impacts, and from new methods that combine meta-study findings to advance our understanding of human-environmental systems.

Applications of integrated human error identification techniques on the chemical cylinder change task.

PubMed

Cheng, Ching-Min; Hwang, Sheue-Ling

2015-03-01

This paper outlines the human error identification (HEI) techniques that currently exist to assess latent human errors. Many formal error identification techniques have existed for years, but few have been validated to cover latent human error analysis in different domains. This study considers many possible error modes and influential factors, including external error modes, internal error modes, psychological error mechanisms, and performance shaping factors, and integrates several execution procedures and frameworks of HEI techniques. The case study in this research was the operational process of changing chemical cylinders in a factory. In addition, the integrated HEI method was used to assess the operational processes and the system's reliability. It was concluded that the integrated method is a valuable aid to develop much safer operational processes and can be used to predict human error rates on critical tasks in the plant. Copyright © 2014 Elsevier Ltd and The Ergonomics Society. All rights reserved.

Human Systems Engineering: A Leadership Model for Collaboration and Change.

ERIC Educational Resources Information Center

Clark, Karen L.

Human systems engineering (HSE) was created to introduce a new way of viewing collaboration. HSE emphasizes the role of leaders who welcome risk, commit to achieving positive change, and help others achieve change. The principles of HSE and its successful application to the collaborative process were illustrated through a case study representing a…

Used planet: a global history.

PubMed

Ellis, Erle C; Kaplan, Jed O; Fuller, Dorian Q; Vavrus, Steve; Klein Goldewijk, Kees; Verburg, Peter H

2013-05-14

Human use of land has transformed ecosystem pattern and process across most of the terrestrial biosphere, a global change often described as historically recent and potentially catastrophic for both humanity and the biosphere. Interdisciplinary paleoecological, archaeological, and historical studies challenge this view, indicating that land use has been extensive and sustained for millennia in some regions and that recent trends may represent as much a recovery as an acceleration. Here we synthesize recent scientific evidence and theory on the emergence, history, and future of land use as a process transforming the Earth System and use this to explain why relatively small human populations likely caused widespread and profound ecological changes more than 3,000 y ago, whereas the largest and wealthiest human populations in history are using less arable land per person every decade. Contrasting two spatially explicit global reconstructions of land-use history shows that reconstructions incorporating adaptive changes in land-use systems over time, including land-use intensification, offer a more spatially detailed and plausible assessment of our planet's history, with a biosphere and perhaps even climate long ago affected by humans. Although land-use processes are now shifting rapidly from historical patterns in both type and scale, integrative global land-use models that incorporate dynamic adaptations in human-environment relationships help to advance our understanding of both past and future land-use changes, including their sustainability and potential global effects.

Disturbance in boreal forest ecosystems: human impacts and natural processes. Proceedings of the International Boreal Forest Research Association 1997 annual meeting; 1997 August 4-7; Duluth, Minnesota.

Treesearch

2000-01-01

The papers in these proceedings cover a wide range of topics related to human and natural disturbance processes in forests of the boreal zone in North America and Eurasia. Topics include historic and predicted landscape change; forest management; disturbance by insects, fire, air pollution, severe weather, and global climate change; and carbon cycling.

From nature-dominated to human-dominated environmental changes

NASA Astrophysics Data System (ADS)

Messerli, Bruno; Grosjean, Martin; Hofer, Thomas; Núñez, Lautaro; Pfister, Christian

2000-01-01

To what extent is it realistic and useful to view human history as a sequence of changes from highly vulnerable societies of hunters and gatherers through periods with less vulnerable, well buffered and highly productive agrarian-urban societies to a world with regions of extreme overpopulation and overuse of life support systems, so that vulnerability to climatic-environmental changes and extreme events is again increasing? This question cannot be fully answered in our present state of knowledge, but at least we can try to illustrate, with three case studies from different continents, time periods and ecosystems, some fundamental changes in the relationship between natural processes and human activities that occur, as we pass from a nature-dominated to a human dominated environment. 1. Early-mid Holocene: Nature dominated environment — human adaptation, mitigation, and migration. In the central Andes, the Holocene climate changed from humid (10,800-8000 BP) to extreme arid (8000-3600 BP) conditions. Over the same period, prehistoric hunting communities adopted a more sedentary pattern of resource use by settling close to the few perennial water bodies, where they began the process of domesticating camelids around 5000 BP and irrigation from about 3100 BP. 2. Historical period: An agrarian society in transition from an "enduring" to an innovative human response. Detailed documentary evidence from Western Europe may be used to reconstruct quite precisely the impacts of climatic variations on agrarian societies. The period considered spans a major transition from an apparently passive response to the vagaries of the environment during the 16th century to an active and innovative attitude from the onset of the agrarian revolution in the late 18th century through to the present day. The associated changes in technology and in agricultural practices helped to create a society better able to survive the impact of climatic extremes. 3. The present day: A human dominated environment with increasing vulnerability of societies and economies to extreme events and natural variability. The third example, dealing with the history and impact of floods in Bangladesh, shows the increasing vulnerability of an over-exploited and human-dominated ecosystem. Measurements exist for a short time only (decades), historical data allow a prolongation of the record into the last century, and paleo-research provides the long-term record of processes operating over millennia. The long-term paleo-perspective is essential for a better understanding of future potential impacts on an increasingly human-dominated environment. Understanding today's global change processes calls for several new perspectives and synergisms: the integration of biophysically oriented climate change research with research about the increasingly dominant processes of human forcing, a focus on overexploited or limited natural resources and on vulnerable and critical regions, fuller use of our understanding of variability on a range of different timescales: "The present without a past has no future".

Change Process in Organizations [in HRD].

ERIC Educational Resources Information Center

1995

These four papers are from a symposium that was facilitated by Toni Powell on the change process in organizations at the 1995 Academy of Human Resource Development (HRD) conference. "The Effectiveness of Change Agents as Affected by Strategic Interactions" (Marie A. George) explores the nature of strategic interactions exhibited by a chief…

Evolution and genomics of the human brain.

PubMed

Rosales-Reynoso, M A; Juárez-Vázquez, C I; Barros-Núñez, P

2018-05-01

Most living beings are able to perform actions that can be considered intelligent or, at the very least, the result of an appropriate reaction to changing circumstances in their environment. However, the intelligence or intellectual processes of humans are vastly superior to those achieved by all other species. The adult human brain is a highly complex organ weighing approximately 1500g, which accounts for only 2% of the total body weight but consumes an amount of energy equal to that required by all skeletal muscle at rest. Although the human brain displays a typical primate structure, it can be identified by its specific distinguishing features. The process of evolution and humanisation of the Homo sapiens brain resulted in a unique and distinct organ with the largest relative volume of any animal species. It also permitted structural reorganization of tissues and circuits in specific segments and regions. These steps explain the remarkable cognitive abilities of modern humans compared not only with other species in our genus, but also with older members of our own species. Brain evolution required the coexistence of two adaptation mechanisms. The first involves genetic changes that occur at the species level, and the second occurs at the individual level and involves changes in chromatin organisation or epigenetic changes. The genetic mechanisms include: a) genetic changes in coding regions that lead to changes in the sequence and activity of existing proteins; b) duplication and deletion of previously existing genes; c) changes in gene expression through changes in the regulatory sequences of different genes; and d) synthesis of non-coding RNAs. Lastly, this review describes some of the main documented chromosomal differences between humans and great apes. These differences have also contributed to the evolution and humanisation process of the H. sapiens brain. Copyright © 2014 Sociedad Española de Neurología. Publicado por Elsevier España, S.L.U. All rights reserved.

Long-term human response to uncertain environmental conditions in the Andes

PubMed Central

Dillehay, Tom D.; Kolata, Alan L.

2004-01-01

Human interaction with the physical environment has increasingly transformed Earth-system processes. Reciprocally, climate anomalies and other processes of environmental change of natural and anthropogenic origin have been affecting, and often disrupting, societies throughout history. Transient impact events, despite their brevity, can have significant long-term impact on society, particularly if they occur in the context of ongoing, protracted environmental change. Major climate events can affect human activities in critical conjunctures that shape particular trajectories of social development. Here we report variable human responses to major environmental events in the Andes with a particular emphasis on the period from anno Domini 500–1500 on the desert north coast of Perú. We show that preindustrial agrarian societies implemented distinct forms of anticipatory response to environmental change and uncertainty. We conclude that innovations in production strategies and agricultural infrastructures in these indigenous societies reflect differential social response to both transient (El Niño–Southern Oscillation events) and protracted (desertification) environmental change. PMID:15024122

Understanding and Projecting Climate and Human Impacts on Terrestrial-Coastal Carbon and Nutrient Fluxes

NASA Astrophysics Data System (ADS)

Lohrenz, S. E.; Cai, W. J.; Tian, H.; He, R.; Fennel, K.

2017-12-01

Changing climate and land use practices have the potential to dramatically alter coupled hydrologic-biogeochemical processes and associated movement of water, carbon and nutrients through various terrestrial reservoirs into rivers, estuaries, and coastal ocean waters. Consequences of climate- and land use-related changes will be particularly evident in large river basins and their associated coastal outflow regions. Here, we describe a NASA Carbon Monitoring System project that employs an integrated suite of models in conjunction with remotely sensed as well as targeted in situ observations with the objectives of describing processes controlling fluxes on land and their coupling to riverine, estuarine and ocean ecosystems. The nature of our approach, coupling models of terrestrial and ocean ecosystem dynamics and associated carbon processes, allows for assessment of how societal and human-related land use, land use change and forestry and climate-related change affect terrestrial carbon transport as well as export of materials through watersheds to the coastal margins. Our objectives include the following: 1) Provide representation of carbon processes in the terrestrial ecosystem to understand how changes in land use and climatic conditions influence the export of materials to the coastal ocean, 2) Couple the terrestrial exports of carbon, nutrients and freshwater to a coastal biogeochemical model and examine how different climate and land use scenarios influence fluxes across the land-ocean interface, and 3) Project future changes under different scenarios of climate and human impact, and support user needs related to carbon management and other activities (e.g., water quality, hypoxia, ocean acidification). This research is providing information that will contribute to determining an overall carbon balance in North America as well as describing and predicting how human- and climate-related changes impact coastal water quality including possible effects of coastal eutrophication and hypoxia.

Dynamic Landscapes and Sea Level Change in Human Evolution and Dispersal

NASA Astrophysics Data System (ADS)

King, G. C.; Devès, M. H.; Bailey, G.; Inglis, R.; Williams, M.

2012-12-01

Archaeological studies of human settlement in its wider landscape setting usually focus on climate change as the principal environmental driver of change in the physical features of the landscape, even on the long time scales of early human evolution. We emphasize that landscapes evolve dynamically due to an interplay of processes occurring over different timescales. Tectonic deformation, volcanism, sea level changes, by acting on the topography, the lithology and on the patterns of erosion-deposition in a given area, can moderate or amplify the influence of climate at the regional and local scale. These processes impose or alleviate physical barriers to movement, and modify the distribution and accessibility of plant and animal resources in ways critical to human ecological and evolutionary success (King and Bailey, JHE 2006; Bailey and King, Antiquity 2011). The DISPERSE project, an ERC-funded collaboration between the University of York and the Institut de Physique du Globe de Paris,are developing systematic methods for reconstructing landscapes associated with active tectonics, volcanism and sea level change at a variety of scales in order to study their potential impact on patterns of human evolution and dispersal. These approaches use remote sensing techniques combined with archaeological and tectonic field surveys on land and underwater. Examples are shown from Europe, the Middle East and Africa to illustrate the ways in which changes of significance to human settlement can occur at a range of geographical scales and on time scales that range from lifetimes to tens of millennia, creating and sustaining attractive conditions for human settlement and exercising powerful selective pressures on human development.

Treat me right, treat me equal: using national policy and legislation to create positive changes in local health services for people with intellectual disabilities.

PubMed

Roberts, Amanda; Townsend, Samantha; Morris, Jennifer; Rushbrooke, Elizabeth; Greenhill, Beth; Whitehead, Richard; Matthews, Tim; Golding, Laura

2013-01-01

Creative use of legislation can produce positive change in the lives of people with intellectual disabilities. This may be 'bottom-up' or 'top-down' or at multiple levels and with multiple stakeholders. Using a human rights-based approach (HRBA), four initiatives to improve services for people with intellectual disabilities in the UK are described. The first example explains the process of co-producing a DVD and board game to enable people with intellectual disabilities to understand their human rights. The second example considers the impact of organizational culture in the process of embedding a pilot evaluation of practical, human rights-based risk assessment and management tools. A third pilot project examines how the guiding principles of Mental Health Act (MHA) (2007) for England and Wales can be operationalized using an HRBA. Finally, improving equitable access to health care through a 'top-down' process of change involving the Green Light Toolkit is reported. The authors consider how to approach the process and where to focus in the system, to realize meaningful change. © 2012 Blackwell Publishing Ltd.

Climate change impact assessments on the water resources of India under extensive human interventions.

PubMed

Madhusoodhanan, C G; Sreeja, K G; Eldho, T I

2016-10-01

Climate change is a major concern in the twenty-first century and its assessments are associated with multiple uncertainties, exacerbated and confounded in the regions where human interventions are prevalent. The present study explores the challenges for climate change impact assessment on the water resources of India, one of the world's largest human-modified systems. The extensive human interventions in the Energy-Land-Water-Climate (ELWC) nexus significantly impact the water resources of the country. The direct human interventions in the landscape may surpass/amplify/mask the impacts of climate change and in the process also affect climate change itself. Uncertainties in climate and resource assessments add to the challenge. Formulating coherent resource and climate change policies in India would therefore require an integrated approach that would assess the multiple interlinkages in the ELWC nexus and distinguish the impacts of global climate change from that of regional human interventions. Concerted research efforts are also needed to incorporate the prominent linkages in the ELWC nexus in climate/earth system modelling.

Dynamic landscapes in human evolution and dispersal

NASA Astrophysics Data System (ADS)

Devès, Maud; King, Geoffrey; Bailey, Geoffrey; Inglis, Robyn; Williams, Matthew; Winder, Isabelle

2013-04-01

Archaeological studies of human settlement in its wider landscape setting usually focus on climate change as the principal environmental driver of change in the physical features of the landscape, even on the long time scales of early human evolution. We emphasize that landscapes evolve dynamically due to an interplay of processes occurring over different timescales. Tectonic deformation, volcanism, sea level changes, by acting on the topography, the lithology and on the patterns of erosion-deposition in a given area, can moderate or amplify the influence of climate at the regional and local scale. These processes impose or alleviate physical barriers to movement, and modify the distribution and accessibility of plant and animal resources in ways critical to human ecological and evolutionary success (King and Bailey, JHE 2006; Bailey and King, Antiquity 2011, Winder et al. Antiquity in press). The DISPERSE project, an ERC-funded collaboration between the University of York and the Institut de Physique du Globe de Paris, aims to develop systematic methods for reconstructing landscapes associated with active tectonics, volcanism and sea level change at a variety of scales in order to study their potential impact on patterns of human evolution and dispersal. Examples are shown to illustrate the ways in which changes of significance to human settlement can occur at a range of geographical scales and on time scales that range from lifetimes to tens of millennia, creating and sustaining attractive conditions for human settlement and exercising powerful selective pressures on human development.

Concordance in Genomic Changes Between Mouse Lungs and Human Airway Epithelial Cells Exposed to Diesel Exhaust Particles

EPA Science Inventory

Human and animal toxicity studies have shown that exposure to diesel exhaust particles (DEP) or their constituents affect multiple biological processes including immune and inflammatory pathways, mutagenesis and in some cases carcinogenesis. This study compared genomic changes by...

Climate Change and Socio-Hydrological Dynamics: Adaptations and Feedbacks

NASA Astrophysics Data System (ADS)

Woyessa, Yali E.; Welderufael, Worku A.

2012-10-01

A functioning ecological system results in ecosystem goods and services which are of direct value to human beings. Ecosystem services are the conditions and processes which sustain and fulfil human life, and maintain biodiversity and the production of ecosystem goods. However, human actions affect ecological systems and the services they provide through various activities, such as land use, water use, pollution and climate change. Climate change is perhaps one of the most important sustainable development challenges that threatens to undo many of the development efforts being made to reach the targets set for the Millennium Development Goals. Understanding the provision of ecosystem services and how they change under different scenarios of climate and biophysical conditions could assist in bringing the issue of ecosystem services into decision making process. Similarly, the impacts of land use change on ecosystems and biodiversity have received considerable attention from ecologists and hydrologists alike. Land use change in a catchment can impact on water supply by altering hydrological processes, such as infiltration, groundwater recharge, base flow and direct runoff. In the past a variety of models were used for predicting landuse changes. Recently, the focus has shifted away from using mathematically oriented models to agent-based modeling (ABM) approach to simulate land use scenarios. The agent-based perspective, with regard to land-use cover change, is centered on the general nature and rules of land-use decision making by individuals. A conceptual framework is developed to investigate the possibility of incorporating the human dimension of land use decision and climate change model into a hydrological model in order to assess the impact of future land use scenario and climate change on the ecological system in general and water resources in particular.

Effects of Plant Traits on Ecosystem and Regional Processes: a Conceptual Framework for Predicting the Consequences of Global Change

PubMed Central

CHAPIN, F. STUART

2003-01-01

Human activities are causing widespread changes in the species composition of natural and managed ecosystems, but the consequences of these changes are poorly understood. This paper presents a conceptual framework for predicting the ecosystem and regional consequences of changes in plant species composition. Changes in species composition have greatest ecological effects when they modify the ecological factors that directly control (and respond to) ecosystem processes. These interactive controls include: functional types of organisms present in the ecosystem; soil resources used by organisms to grow and reproduce; modulators such as microclimate that influence the activity of organisms; disturbance regime; and human activities. Plant traits related to size and growth rate are particularly important because they determine the productive capacity of vegetation and the rates of decomposition and nitrogen mineralization. Because the same plant traits affect most key processes in the cycling of carbon and nutrients, changes in plant traits tend to affect most biogeochemical cycling processes in parallel. Plant traits also have landscape and regional effects through their effects on water and energy exchange and disturbance regime. PMID:12588725

A Framework for Business Process Change Requirements Analysis

NASA Astrophysics Data System (ADS)

Grover, Varun; Otim, Samuel

The ability to quickly and continually adapt business processes to accommodate evolving requirements and opportunities is critical for success in competitive environments. Without appropriate linkage between redesign decisions and strategic inputs, identifying processes that need to be modified will be difficult. In this paper, we draw attention to the analysis of business process change requirements in support of process change initiatives. Business process redesign is a multifaceted phenomenon involving processes, organizational structure, management systems, human resource architecture, and many other aspects of organizational life. To be successful, the business process initiative should focus not only on identifying the processes to be redesigned, but also pay attention to various enablers of change. Above all, a framework is just a blueprint; management must lead change. We hope our modest contribution will draw attention to the broader framing of requirements for business process change.

Used planet: A global history

PubMed Central

Ellis, Erle C.; Kaplan, Jed O.; Fuller, Dorian Q.; Vavrus, Steve; Klein Goldewijk, Kees; Verburg, Peter H.

2013-01-01

Human use of land has transformed ecosystem pattern and process across most of the terrestrial biosphere, a global change often described as historically recent and potentially catastrophic for both humanity and the biosphere. Interdisciplinary paleoecological, archaeological, and historical studies challenge this view, indicating that land use has been extensive and sustained for millennia in some regions and that recent trends may represent as much a recovery as an acceleration. Here we synthesize recent scientific evidence and theory on the emergence, history, and future of land use as a process transforming the Earth System and use this to explain why relatively small human populations likely caused widespread and profound ecological changes more than 3,000 y ago, whereas the largest and wealthiest human populations in history are using less arable land per person every decade. Contrasting two spatially explicit global reconstructions of land-use history shows that reconstructions incorporating adaptive changes in land-use systems over time, including land-use intensification, offer a more spatially detailed and plausible assessment of our planet's history, with a biosphere and perhaps even climate long ago affected by humans. Although land-use processes are now shifting rapidly from historical patterns in both type and scale, integrative global land-use models that incorporate dynamic adaptations in human–environment relationships help to advance our understanding of both past and future land-use changes, including their sustainability and potential global effects. PMID:23630271

The U.S. Climate Change Science Program. Vision for the Program and Highlights of the Scientific Strategic Plan

DTIC Science & Technology

2003-07-01

CH4, N2O, O3, etc. Aerosols Clouds ATMOSPHERIC COMPOSITION WATER CYCLE LAND-USE/ LAND-COVER CHANGE HUMAN CONTRIBUTIONS AND RESPONSES CARBON...Oceanographic Institution. Climate Variability and Change ATMOSPHERIC COMPOSITION CLIMATE VARIABILITY AND CHANGE GLOBAL WATER CYCLE LAND-USE/LAND-COVER CHANGE...their access to and use of water. CCSP-supported research on the global water cycle focuses on how natural processes and human activities influence the

Unraveling the evolution of uniquely human cognition.

PubMed

MacLean, Evan L

2016-06-07

A satisfactory account of human cognitive evolution will explain not only the psychological mechanisms that make our species unique, but also how, when, and why these traits evolved. To date, researchers have made substantial progress toward defining uniquely human aspects of cognition, but considerably less effort has been devoted to questions about the evolutionary processes through which these traits have arisen. In this article, I aim to link these complementary aims by synthesizing recent advances in our understanding of what makes human cognition unique, with theory and data regarding the processes of cognitive evolution. I review evidence that uniquely human cognition depends on synergism between both representational and motivational factors and is unlikely to be accounted for by changes to any singular cognitive system. I argue that, whereas no nonhuman animal possesses the full constellation of traits that define the human mind, homologies and analogies of critical aspects of human psychology can be found in diverse nonhuman taxa. I suggest that phylogenetic approaches to the study of animal cognition-which can address questions about the selective pressures and proximate mechanisms driving cognitive change-have the potential to yield important insights regarding the processes through which the human cognitive phenotype evolved.

Challenges of Global Change for Lakes

NASA Astrophysics Data System (ADS)

Seekell, D.

2016-12-01

Lakes comprise a tiny fraction of Earth's surface, but contribute significantly to human life and wellbeing. Many lakes are disappearing due to climate change and water diversions, and there are widespread disruptions to ecosystem processes due to human influences. For example, pollution by nutrients and toxic chemicals causes toxicity to humans, livestock, fish, and wildlife. Lake desiccation reduces economic opportunity and food security, displacing entire communities. Understanding these changes at the global scale, and their implications for human societies, are a key challenges for aquatic scientists. In this talk, I will use results from my research to highlight some of the key uncertainties related to global change and lakes, as well as recent developments by aquatic scientists aimed at predicting, mitigating, and coping with these changes.

Our changing planet: The FY 1993 US global change research program. A supplement to the US President's fiscal year 1993 budget

NASA Technical Reports Server (NTRS)

1992-01-01

An improved predictive understanding of the integrated Earth system, including human interactions, will provide direct benefits by anticipating and planning for possible impacts on commerce, agriculture, energy, resource utilization, human safety, and environmental quality. The central goal of the U.S. Global Change Research Program (USGCRP) is to help establish the scientific understanding and the basis for national and international policymaking related to natural and human-induced changes in the global Earth system. This will be accomplished through: (1) establishing an integrated, comprehensive, long-term program of documenting the Earth system on a global scale; (2) conducting a program of focused studies to improve our understanding of the physical, geological, chemical, biological, and social processes that influence the Earth system processes; and (3) developing integrated conceptual and predictive Earth system models.

Maximizing Empower on a Human-dominated Planet: The Role of Exotic Spartina (Eco Eng.)

EPA Science Inventory

The emergy signature of the Earth has changed dramatically over the past 250 years as a result of the development of technologies to use fossil fuels for human purposes. This change has resulted in the self-organization of modern industrial societies and their concomitant process...

Innovative Staffing To Meet Technological Changes: A Case Study at Wake Forest University.

ERIC Educational Resources Information Center

Ganzert, Robin Roy; Watkins, Dawn Adele

1997-01-01

Examines the changes surrounding information technology as it relates to staffing issues at Wake Forest University (Winston-Salem, North Carolina). Highlights include: revision of organizational structure; decentralization of human resources processes; a survey of personnel attitudes; and trends for the human resources department. (AEF)

A conceptual connectivity framework for understanding geomorphic change in human-impacted fluvial systems

NASA Astrophysics Data System (ADS)

Poeppl, Ronald E.; Keesstra, Saskia D.; Maroulis, Jerry

2017-01-01

Human-induced landscape change is difficult to predict due to the complexity inherent in both geomorphic and social systems as well as due to the coupling relationships between them. To better understand system complexity and system response to changing inputs, "connectivity thinking" has become an important recent paradigm within various disciplines including ecology, hydrology and geomorphology. With the presented conceptual connectivity framework on geomorphic change in human-impacted fluvial systems a cautionary note is flagged regarding the need (i) to include and to systematically conceptualise the role of different types of human agency in altering connectivity relationships in geomorphic systems and (ii) to integrate notions of human-environment interactions to connectivity concepts in geomorphology to better explain causes and trajectories of landscape change. Geomorphic response of fluvial systems to human disturbance is shown to be determined by system-specific boundary conditions (incl. system history, related legacy effects and lag times), vegetation dynamics and human-induced functional relationships (i.e. feedback mechanisms) between the different spatial dimensions of connectivity. It is further demonstrated how changes in social systems can trigger a process-response feedback loop between social and geomorphic systems that further governs the trajectory of landscape change in coupled human-geomorphic systems.

Ecosystem Services Connect Environmental Change to Human Health Outcomes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bayles, Brett R.; Brauman, Kate A.; Adkins, Joshua N.

Global environmental change, driven in large part by human activities, profoundly impacts the structure and functioning of Earth’s ecosystems (Millennium Ecosystem Assessment 2005). We are beginning to push beyond planetary boundaries (Steffan et al. 2015), and the consequences for human health remain largely unknown (Myers et al. 2013). Growing evidence suggests that ecological transformations can dramatically affect human health in ways that are both obvious and obscure (Myers and Patz 2009; Myers et al. 2013). The framework of ecosystem services, designed to evaluate the benefits that people derive from ecosystem products and processes, provides a compelling framework for integrating themore » many factors that influence the human health response to global change, as well as for integrating health impacts into broader analyses of the impacts of this change« less

Adapting to and coping with the threat and impacts of climate change.

PubMed

Reser, Joseph P; Swim, Janet K

2011-01-01

This article addresses the nature and challenge of adaptation in the context of global climate change. The complexity of "climate change" as threat, environmental stressor, risk domain, and impacting process with dramatic environmental and human consequences requires a synthesis of perspectives and models from diverse areas of psychology to adequately communicate and explain how a more psychological framing of the human dimensions of global environmental change can greatly inform and enhance effective and collaborative climate change adaptation and mitigation policies and research. An integrative framework is provided that identifies and considers important mediating and moderating parameters and processes relating to climate change adaptation, with particular emphasis given to environmental stress and stress and coping perspectives. This psychological perspective on climate change adaptation highlights crucial aspects of adaptation that have been neglected in the arena of climate change science. Of particular importance are intra-individual and social "psychological adaptation" processes that powerfully mediate public risk perceptions and understandings, effective coping responses and resilience, overt behavioral adjustment and change, and psychological and social impacts. This psychological window on climate change adaptation is arguably indispensable to genuinely multidisciplinary and interdisciplinary research and policy initiatives addressing the impacts of climate change.

Electrophysiological and hemodynamic mismatch responses in rats listening to human speech syllables.

PubMed

Mahmoudzadeh, Mahdi; Dehaene-Lambertz, Ghislaine; Wallois, Fabrice

2017-01-01

Speech is a complex auditory stimulus which is processed according to several time-scales. Whereas consonant discrimination is required to resolve rapid acoustic events, voice perception relies on slower cues. Humans, right from preterm ages, are particularly efficient to encode temporal cues. To compare the capacities of preterms to those observed in other mammals, we tested anesthetized adult rats by using exactly the same paradigm as that used in preterm neonates. We simultaneously recorded neural (using ECoG) and hemodynamic responses (using fNIRS) to series of human speech syllables and investigated the brain response to a change of consonant (ba vs. ga) and to a change of voice (male vs. female). Both methods revealed concordant results, although ECoG measures were more sensitive than fNIRS. Responses to syllables were bilateral, but with marked right-hemispheric lateralization. Responses to voice changes were observed with both methods, while only ECoG was sensitive to consonant changes. These results suggest that rats more effectively processed the speech envelope than fine temporal cues in contrast with human preterm neonates, in whom the opposite effects were observed. Cross-species comparisons constitute a very valuable tool to define the singularities of the human brain and species-specific bias that may help human infants to learn their native language.

Archaeogenomic insights into the adaptation of plants to the human environment: pushing plant-hominin co-evolution back to the Pliocene.

PubMed

Allaby, Robin G; Kistler, Logan; Gutaker, Rafal M; Ware, Roselyn; Kitchen, James L; Smith, Oliver; Clarke, Andrew C

2015-02-01

The colonization of the human environment by plants, and the consequent evolution of domesticated forms is increasingly being viewed as a co-evolutionary plant-human process that occurred over a long time period, with evidence for the co-evolutionary relationship between plants and humans reaching ever deeper into the hominin past. This developing view is characterized by a change in emphasis on the drivers of evolution in the case of plants. Rather than individual species being passive recipients of artificial selection pressures and ultimately becoming domesticates, entire plant communities adapted to the human environment. This evolutionary scenario leads to systems level genetic expectations from models that can be explored through ancient DNA and Next Generation Sequencing approaches. Emerging evidence suggests that domesticated genomes fit well with these expectations, with periods of stable complex evolution characterized by large amounts of change associated with relatively small selective value, punctuated by periods in which changes in one-half of the plant-hominin relationship cause rapid, low-complexity adaptation in the other. A corollary of a single plant-hominin co-evolutionary process is that clues about the initiation of the domestication process may well lie deep within the hominin lineage. Copyright © 2014 The Authors. Published by Elsevier Ltd.. All rights reserved.

Science, Technology, and the Human Equation: Developing a New Paradigm for Education.

ERIC Educational Resources Information Center

Hartoonian, H. Michael

Since technology is a function within and a dominant part of the human equation, it is important to develop theories of social institutions and change consistent with the present electronic revolution, in order to avoid becoming "tools of our tools." Our intellectual and technological evolutionary process must change to accommodate the…

Observation of temperature trace, induced by changing of temperature inside the human body, on the human body skin using commercially available IR camera

NASA Astrophysics Data System (ADS)

Trofimov, Vyacheslav A.; Trofimov, Vladislav V.

2015-05-01

As it is well-known, application of the passive THz camera for the security problems is very promising way. It allows seeing concealed object without contact with a person and this camera is non-dangerous for a person. In previous papers, we demonstrate new possibility of the passive THz camera using for a temperature difference observing on the human skin if this difference is caused by different temperatures inside the body. For proof of validity of our statement we make the similar physical experiment using the IR camera. We show a possibility of temperature trace on human body skin, caused by changing of temperature inside the human body due to water drinking. We use as a computer code that is available for treatment of images captured by commercially available IR camera, manufactured by Flir Corp., as well as our developed computer code for computer processing of these images. Using both codes we demonstrate clearly changing of human body skin temperature induced by water drinking. Shown phenomena are very important for the detection of forbidden samples and substances concealed inside the human body using non-destructive control without X-rays using. Early we have demonstrated such possibility using THz radiation. Carried out experiments can be used for counter-terrorism problem solving. We developed original filters for computer processing of images captured by IR cameras. Their applications for computer processing of images results in a temperature resolution enhancing of cameras.

Climate Change: Modeling the Human Response

NASA Astrophysics Data System (ADS)

Oppenheimer, M.; Hsiang, S. M.; Kopp, R. E.

2012-12-01

Integrated assessment models have historically relied on forward modeling including, where possible, process-based representations to project climate change impacts. Some recent impact studies incorporate the effects of human responses to initial physical impacts, such as adaptation in agricultural systems, migration in response to drought, and climate-related changes in worker productivity. Sometimes the human response ameliorates the initial physical impacts, sometimes it aggravates it, and sometimes it displaces it onto others. In these arenas, understanding of underlying socioeconomic mechanisms is extremely limited. Consequently, for some sectors where sufficient data has accumulated, empirically based statistical models of human responses to past climate variability and change have been used to infer response sensitivities which may apply under certain conditions to future impacts, allowing a broad extension of integrated assessment into the realm of human adaptation. We discuss the insights gained from and limitations of such modeling for benefit-cost analysis of climate change.

A Comparison of Natural Language Processing Methods for Automated Coding of Motivational Interviewing.

PubMed

Tanana, Michael; Hallgren, Kevin A; Imel, Zac E; Atkins, David C; Srikumar, Vivek

2016-06-01

Motivational interviewing (MI) is an efficacious treatment for substance use disorders and other problem behaviors. Studies on MI fidelity and mechanisms of change typically use human raters to code therapy sessions, which requires considerable time, training, and financial costs. Natural language processing techniques have recently been utilized for coding MI sessions using machine learning techniques, rather than human coders, and preliminary results have suggested these methods hold promise. The current study extends this previous work by introducing two natural language processing models for automatically coding MI sessions via computer. The two models differ in the way they semantically represent session content, utilizing either 1) simple discrete sentence features (DSF model) and 2) more complex recursive neural networks (RNN model). Utterance- and session-level predictions from these models were compared to ratings provided by human coders using a large sample of MI sessions (N=341 sessions; 78,977 clinician and client talk turns) from 6 MI studies. Results show that the DSF model generally had slightly better performance compared to the RNN model. The DSF model had "good" or higher utterance-level agreement with human coders (Cohen's kappa>0.60) for open and closed questions, affirm, giving information, and follow/neutral (all therapist codes); considerably higher agreement was obtained for session-level indices, and many estimates were competitive with human-to-human agreement. However, there was poor agreement for client change talk, client sustain talk, and therapist MI-inconsistent behaviors. Natural language processing methods provide accurate representations of human derived behavioral codes and could offer substantial improvements to the efficiency and scale in which MI mechanisms of change research and fidelity monitoring are conducted. Copyright © 2016 Elsevier Inc. All rights reserved.

Problematics of Time and Timing in the Longitudinal Study of Human Development: Theoretical and Methodological Issues

PubMed Central

Lerner, Richard M.; Schwartz, Seth J; Phelps, Erin

2009-01-01

Studying human development involves describing, explaining, and optimizing intraindividual change and interindividual differences in such change and, as such, requires longitudinal research. The selection of the appropriate type of longitudinal design requires selecting the option that best addresses the theoretical questions asked about developmental process and the use of appropriate statistical procedures to best exploit data derived from theory-predicated longitudinal research. This paper focuses on several interrelated problematics involving the treatment of time and the timing of observations that developmental scientists face in creating theory-design fit and in charting in change-sensitive ways developmental processes across life. We discuss ways in which these problematics may be addressed to advance theory-predicated understanding of the role of time in processes of individual development. PMID:19554215

Feedbacks in Human-Landscape Systems

NASA Astrophysics Data System (ADS)

Chin, Anne; Florsheim, Joan L.; Wohl, Ellen; Collins, Brian D.

2014-01-01

This article identifies key questions and challenges for geomorphologists in investigating coupled feedbacks in human-landscape systems. While feedbacks occur in the absence of human influences, they are also altered by human activity. Feedbacks are a key element to understanding human-influenced geomorphic systems in ways that extend our traditional approach of considering humans as unidirectional drivers of change. Feedbacks have been increasingly identified in Earth-environmental systems, with studies of coupled human-natural systems emphasizing ecological phenomena in producing emerging concepts for social-ecological systems. Enormous gaps or uncertainties in knowledge remain with respect to understanding impact-feedback loops within geomorphic systems with significant human alterations, where the impacted geomorphic systems in turn affect humans. Geomorphology should play an important role in public policy by identifying the many diffuse and subtle feedbacks of both local- and global-scale processes. This role is urgent, while time may still be available to mitigate the impacts that limit the sustainability of human societies. Challenges for geomorphology include identification of the often weak feedbacks that occur over varied time and space scales ranging from geologic time to single isolated events and very short time periods, the lack of available data linking impact with response, the identification of multiple thresholds that trigger feedback mechanisms, the varied tools and metrics needed to represent both physical and human processes, and the need to collaborate with social scientists with expertise in the human causes of geomorphic change, as well as the human responses to such change.

Separating the impacts of climate change and human activities on streamflow: A review of methodologies and critical assumptions

NASA Astrophysics Data System (ADS)

Dey, Pankaj; Mishra, Ashok

2017-05-01

Climate change and human activity are two major drivers that alter hydrological cycle processes and cause change in spatio-temporal distribution of water availability. Streamflow, the most important component of hydrological cycle undergoes variation which is expected to be influenced by climate change as well as human activities. Since these two affecting conditions are time dependent, having unequal influence, identification of the change point in natural flow regime is of utmost important to separate the individual impact of climate change and human activities on streamflow variability. Subsequently, it is important as well for framing adaptation strategies and policies for regional water resources planning and management. In this paper, a comprehensive review of different approaches used by research community to isolate the impacts of climate change and human activities on streamflow are presented. The important issues pertaining to different approaches, to make rational use of methodology, are discussed so that researcher and policymaker can understand the importance of individual methodology and its use in water resources management. A new approach has also been suggested to select a representative change point under different scenarios of human activities with incorporation of climate variability/change.

Changing Times: Changing Libraries.

ERIC Educational Resources Information Center

Bonn, George S., Ed.; Faibisoff, Sylvia, Ed.

This collection of essays and responses by 18 specialists and librarians focuses on three research perspectives: (1) governmental, economic, and technological changes; (2) possible results of change in the humanities, education, and social institutions; and (3) the process of change and ways to create conditions for change. Each specialist's essay…

Aging and Gene Expression in the Primate Brain

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fraser, Hunter B.; Khaitovich, Philipp; Plotkin, Joshua B.

2005-02-18

It is well established that gene expression levels in many organisms change during the aging process, and the advent of DNA microarrays has allowed genome-wide patterns of transcriptional changes associated with aging to be studied in both model organisms and various human tissues. Understanding the effects of aging on gene expression in the human brain is of particular interest, because of its relation to both normal and pathological neurodegeneration. Here we show that human cerebral cortex, human cerebellum, and chimpanzee cortex each undergo different patterns of age-related gene expression alterations. In humans, many more genes undergo consistent expression changes inmore » the cortex than in the cerebellum; in chimpanzees, many genes change expression with age in cortex, but the pattern of changes in expression bears almost no resemblance to that of human cortex. These results demonstrate the diversity of aging patterns present within the human brain, as well as how rapidly genome-wide patterns of aging can evolve between species; they may also have implications for the oxidative free radical theory of aging, and help to improve our understanding of human neurodegenerative diseases.« less

Syllabic discrimination in premature human infants prior to complete formation of cortical layers

PubMed Central

Mahmoudzadeh, Mahdi; Dehaene-Lambertz, Ghislaine; Fournier, Marc; Kongolo, Guy; Goudjil, Sabrina; Dubois, Jessica; Grebe, Reinhard; Wallois, Fabrice

2013-01-01

The ontogeny of linguistic functions in the human brain remains elusive. Although some auditory capacities are described before term, whether and how such immature cortical circuits might process speech are unknown. Here we used functional optical imaging to evaluate the cerebral responses to syllables at the earliest age at which cortical responses to external stimuli can be recorded in humans (28- to 32-wk gestational age). At this age, the cortical organization in layers is not completed. Many neurons are still located in the subplate and in the process of migrating to their final location. Nevertheless, we observed several points of similarity with the adult linguistic network. First, whereas syllables elicited larger right than left responses, the posterior temporal region escaped this general pattern, showing faster and more sustained responses over the left than over the right hemisphere. Second, discrimination responses to a change of phoneme (ba vs. ga) and a change of human voice (male vs. female) were already present and involved inferior frontal areas, even in the youngest infants (29-wk gestational age). Third, whereas both types of changes elicited responses in the right frontal region, the left frontal region only reacted to a change of phoneme. These results demonstrate a sophisticated organization of perisylvian areas at the very onset of cortical circuitry, 3 mo before term. They emphasize the influence of innate factors on regions involved in linguistic processing and social communication in humans. PMID:23440196

Mistake proofing: changing designs to reduce error

PubMed Central

Grout, J R

2006-01-01

Mistake proofing uses changes in the physical design of processes to reduce human error. It can be used to change designs in ways that prevent errors from occurring, to detect errors after they occur but before harm occurs, to allow processes to fail safely, or to alter the work environment to reduce the chance of errors. Effective mistake proofing design changes should initially be effective in reducing harm, be inexpensive, and easily implemented. Over time these design changes should make life easier and speed up the process. Ideally, the design changes should increase patients' and visitors' understanding of the process. These designs should themselves be mistake proofed and follow the good design practices of other disciplines. PMID:17142609

The dynamic lift of developmental process.

PubMed

Smith, Linda B; Breazeal, Cynthia

2007-01-01

What are the essential properties of human intelligence, currently unparalleled in its power relative to other biological forms and relative to artificial forms of intelligence? We suggest that answering this question depends critically on understanding developmental process. This paper considers three principles potentially essential to building human-like intelligence: the heterogeneity of the component processes, the embedding of development in a social world, and developmental processes that change the cognitive system as a function of the history of soft-assemblies of these heterogeneous processes in specific tasks. The paper uses examples from human development and from developmental robotics to show how these processes also may underlie biological intelligence and enable us to generate more advanced forms of artificial intelligence.

Toward the Human Element. Beginning Handbook for Change. Volume I.

ERIC Educational Resources Information Center

Prince, Gerald; And Others

The primary aim of this handbook is to encourage and stimulate growth and renewal of the "human element" within the school environment. Four processes form the objectives that are fundamental to achieving this goal: problem solving, shared decision making, open communications, and accountability. Skills in these four processes are discussed in…

Neuroscience Evidence for Economic Humanism in Management Science: Organizational Implications and Strategy.

PubMed

Lattanzi, Nicola; Menicagli, Dario; Dal Maso, Lorenzo

2016-04-01

Globalization phenomena and Information Communication Technology (ICT) are producing deep changes worldwide. The economic environment and society where firms both cooperate and compete with each other are rapidly changing leading firms towards recognizing the role of intangible resources as a source of fresh competitive advantage. Experience, innovation and the ability to create new knowledge completely arise from the act of human resources inviting firms to focus on how to generate and shape knowledge. Therefore, the future of firms depends greatly on how managers are able to explore and exploit human resources. However, without a clear understanding of the nature of human beings and the complexity behind human interactions, we cannot understand the theory of organizational knowledge creation. Thus, how can firms discover, manage and valorize this "human advantage"? Neuroscience can increase the understanding of how cognitive and emotional processes work; in doing so, we may be able to better understand how individuals involved in a business organization make decisions and how external factors influence their behavior, especially in terms of commitment activation and engagement level. In this respect, a neuroscientific approach to business can support managers in decision-making processes. In a scenario where economic humanism plays a central role in the process of fostering firms' competitiveness and emerging strategies, we believe that a neuroscience approach in a business organization could be a valid source of value and inspiration for manager decision-making processes.

Biodiversity redistribution under climate change: Impacts on ecosystems and human well-being.

PubMed

Pecl, Gretta T; Araújo, Miguel B; Bell, Johann D; Blanchard, Julia; Bonebrake, Timothy C; Chen, I-Ching; Clark, Timothy D; Colwell, Robert K; Danielsen, Finn; Evengård, Birgitta; Falconi, Lorena; Ferrier, Simon; Frusher, Stewart; Garcia, Raquel A; Griffis, Roger B; Hobday, Alistair J; Janion-Scheepers, Charlene; Jarzyna, Marta A; Jennings, Sarah; Lenoir, Jonathan; Linnetved, Hlif I; Martin, Victoria Y; McCormack, Phillipa C; McDonald, Jan; Mitchell, Nicola J; Mustonen, Tero; Pandolfi, John M; Pettorelli, Nathalie; Popova, Ekaterina; Robinson, Sharon A; Scheffers, Brett R; Shaw, Justine D; Sorte, Cascade J B; Strugnell, Jan M; Sunday, Jennifer M; Tuanmu, Mao-Ning; Vergés, Adriana; Villanueva, Cecilia; Wernberg, Thomas; Wapstra, Erik; Williams, Stephen E

2017-03-31

Distributions of Earth's species are changing at accelerating rates, increasingly driven by human-mediated climate change. Such changes are already altering the composition of ecological communities, but beyond conservation of natural systems, how and why does this matter? We review evidence that climate-driven species redistribution at regional to global scales affects ecosystem functioning, human well-being, and the dynamics of climate change itself. Production of natural resources required for food security, patterns of disease transmission, and processes of carbon sequestration are all altered by changes in species distribution. Consideration of these effects of biodiversity redistribution is critical yet lacking in most mitigation and adaptation strategies, including the United Nation's Sustainable Development Goals. Copyright © 2017, American Association for the Advancement of Science.

An Integrative Theory of Psychotherapy: Research and Practice

PubMed Central

Epstein, Seymour; Epstein, Martha L.

2016-01-01

A dual-process personality theory and supporting research are presented. The dual processes comprise an experiential system and a rational system. The experiential system is an adaptive, associative learning system that humans share with other higher-order animals. The rational system is a uniquely human, primarily verbal, reasoning system. It is assumed that when humans developed language they did not abandon their previous ways of adapting, they simply added language to their experiential system. The two systems are assumed to operate in parallel and are bi-directionally interactive. The validity of these assumptions is supported by extensive research. Of particular relevance for psychotherapy, the experiential system, which is compatible with evolutionary theory, replaces the Freudian maladaptive unconscious system that is indefensible from an evolutionary perspective, as sub-human animals would then have only a single system that is maladaptive. The aim of psychotherapy is to produce constructive changes in the experiential system. Changes in the rational system are useful only to the extent that they contribute to constructive changes in the experiential system. PMID:27672302

An Integrative Theory of Psychotherapy: Research and Practice.

PubMed

Epstein, Seymour; Epstein, Martha L

2016-06-01

A dual-process personality theory and supporting research are presented. The dual processes comprise an experiential system and a rational system. The experiential system is an adaptive, associative learning system that humans share with other higher-order animals. The rational system is a uniquely human, primarily verbal, reasoning system. It is assumed that when humans developed language they did not abandon their previous ways of adapting, they simply added language to their experiential system. The two systems are assumed to operate in parallel and are bi-directionally interactive. The validity of these assumptions is supported by extensive research. Of particular relevance for psychotherapy, the experiential system, which is compatible with evolutionary theory, replaces the Freudian maladaptive unconscious system that is indefensible from an evolutionary perspective, as sub-human animals would then have only a single system that is maladaptive. The aim of psychotherapy is to produce constructive changes in the experiential system. Changes in the rational system are useful only to the extent that they contribute to constructive changes in the experiential system.

Visual Image Sensor Organ Replacement

NASA Technical Reports Server (NTRS)

Maluf, David A.

2014-01-01

This innovation is a system that augments human vision through a technique called "Sensing Super-position" using a Visual Instrument Sensory Organ Replacement (VISOR) device. The VISOR device translates visual and other sensors (i.e., thermal) into sounds to enable very difficult sensing tasks. Three-dimensional spatial brightness and multi-spectral maps of a sensed image are processed using real-time image processing techniques (e.g. histogram normalization) and transformed into a two-dimensional map of an audio signal as a function of frequency and time. Because the human hearing system is capable of learning to process and interpret extremely complicated and rapidly changing auditory patterns, the translation of images into sounds reduces the risk of accidentally filtering out important clues. The VISOR device was developed to augment the current state-of-the-art head-mounted (helmet) display systems. It provides the ability to sense beyond the human visible light range, to increase human sensing resolution, to use wider angle visual perception, and to improve the ability to sense distances. It also allows compensation for movement by the human or changes in the scene being viewed.

Conceptual and epistemological undercurrents of learning as a process of change

NASA Astrophysics Data System (ADS)

Montfort, Devlin B.

2011-12-01

In the preparation and education of civil engineers it is essential to both increase student knowledge of the world (conceptual understanding), but also to establish and develop new ways of thinking (epistemology). Both of these processes of change can be considered learning, but they are vastly different in the time, energy and resources they require to accomplish. The second type of learning (conceptual change) is more difficult, and is only rarely accomplished in traditional university education. The purpose of this research is to apply existing research approaches from cognitive science and educational psychology to explain why by investigating conceptual change in the contexts of student learning and faculty adoption of new pedagogies. In each context, the difficulty with conceptual change was associated with the ways in which people categorize fundamental phenomena in the world around them, and with epistemological expectations of how those categorizations should be applied in new contexts. While attempts to encourage change often focus on "educating" people by providing them with more knowledge, the change processes seem to be primarily limited by people's existing knowledge and how it is structured. Because civil engineers interact closely with societal goals and processes (such as human safety and environmental policies), they adopt epistemological stances that are as-yet unaccounted for in most research on the subject, which assumes a strong distinction between epistemological stances toward the physical world compared to the social world. These differences suggest that civil engineers' conceptual change could be enhanced by more directly addressing their particular epistemological stances---which incorporate high needs for certainty in guaranteeing human safety, as well as high flexibility when being applied to human systems.

Ethical tissue: a not-for-profit model for human tissue supply.

PubMed

Adams, Kevin; Martin, Sandie

2011-02-01

Following legislative changes in 2004 and the establishment of the Human Tissue Authority, access to human tissues for biomedical research became a more onerous and tightly regulated process. Ethical Tissue was established to meet the growing demand for human tissues, using a process that provided ease of access by researchers whilst maintaining the highest ethical and regulatory standards. The establishment of a licensed research tissue bank entailed several key criteria covering ethical, legal, financial and logistical issues being met. A wide range of stakeholders, including the HTA, University of Bradford, flagged LREC, hospital trusts and clinical groups were also integral to the process.

Voice processing in monkey and human brains.

PubMed

Scott, Sophie K

2008-09-01

Studies in humans have indicated that the anterior superior temporal sulcus has an important role in the processing of information about human voices, especially the identification of talkers from their voice. A new study using functional magnetic resonance imaging (fMRI) with macaques provides strong evidence that anterior auditory fields, part of the auditory 'what' pathway, preferentially respond to changes in the identity of conspecifics, rather than specific vocalizations from the same individual.

Ad hoc committee on global climate issues: Annual report

USGS Publications Warehouse

Gerhard, L.C.; Hanson, B.M.B.

2000-01-01

The AAPG Ad Hoc Committee on Global Climate Issues has studied the supposition of human-induced climate change since the committee's inception in January 1998. This paper details the progress and findings of the committee through June 1999. At that time there had been essentially no geologic input into the global climate change debate. The following statements reflect the current state of climate knowledge from the geologic perspective as interpreted by the majority of the committee membership. The committee recognizes that new data could change its conclusions. The earth's climate is constantly changing owing to natural variability in earth processes. Natural climate variability over recent geological time is greater than reasonable estimates of potential human-induced greenhouse gas changes. Because no tool is available to test the supposition of human-induced climate change and the range of natural variability is so great, there is no discernible human influence on global climate at this time.

Human-polar bear interactions in a changing Arctic: Existing and emerging concerns

USGS Publications Warehouse

Atwood, Todd C.; Simac, Kristin; Breck, Stewart; York, Geoff; Wilder, James

2017-01-01

The behavior and sociality of polar bears (Ursus maritimus) have been shaped by evolved preferences for sea ice habitat and preying on marine mammals. However, human behavior is causing changes to the Arctic marine ecosystem through the influence of greenhouse gas emissions that drive long-term change in ecosystem processes and via the presence of in situ stressors associated with increasing human activities. These changes are making it more difficult for polar bears to reliably use their traditional habitats and maintain fitness. Here, we provide an overview of how human activities in the Arctic are likely to change a polar bear’s behavior and to influence their resilience to environmental change. Developing a more thorough understanding of polar bear behavior and their capacity for flexibility in response to anthropogenic disturbances and subsequent mitigations may lead to successful near-term management interventions.

A conceptual connectivity framework for understanding geomorphic change in human-impacted fluvial systems

NASA Astrophysics Data System (ADS)

Pöppl, Ronald; Keesstra, Saskia; Maroulis, Jerry

2017-04-01

Human-induced landscape change is difficult to predict due to the complexity inherent in both geomorphic and social systems as well as due to emerging coupling relationships between them. To better understand system complexity and system response to change, connectivity has become an important research paradigm within various disciplines including geomorphology, hydrology and ecology. With the proposed conceptual connectivity framework on geomorphic change in human-impacted fluvial systems a cautionary note is flagged regarding the need (i) to include and to systematically conceptualise the role of different types of human agency in altering connectivity relationships in geomorphic systems and (ii) to integrate notions of human-environment interactions to connectivity concepts in geomorphology to better explain causes and trajectories of landscape change. Underpinned by case study examples, the presented conceptual framework is able to explain how geomorphic response of fluvial systems to human disturbance is determined by system-specific boundary conditions (incl. system history, related legacy effects and lag times), vegetation dynamics and human-induced functional relationships (i.e. feedback mechanisms) between the different spatial dimensions of connectivity. It is further demonstrated how changes in social systems can trigger a process-response feedback loop between social and geomorphic systems that further governs the trajectory of landscape change in coupled human-geomorphic systems.

The relative role of climate change and human activities in the desertification process in Yulin region of northwest China.

PubMed

Wang, Tao; Sun, Jian-Guo; Han, Hui; Yan, Chang-Zhen

2012-12-01

To overcome the shortcoming of existing studies, this paper put forward a statistical vegetation-climate relationship model with integrated temporal and spatial characteristics. Based on this model, we quantitatively discriminated on the grid scale the relative role of climate change and human activities in the desertification dynamics from 1986 to 2000 in Yulin region. Yulin region's desertification development occurred mainly in the southern hilly and gully area and its reverse in the northwest sand and marsh area. This spatial pattern was especially evident and has never changed thoroughly. From the first time section (1986-1990) to the second (1991-1995), the desertification was developing as a whole, and either in the desertification development district or in the reverse district human activities' role was always occupying an overwhelmingly dominant position (they were 98.7% and 101.4%, respectively), the role of climate change was extremely slight. From the second time section (1991-1995) to the third (1996-2000), the desertification process was reaching a state of stability, in the desertification development district the role of climate change was nearly equivalent to that of human activities (they were 46.2% and 53.8% separately), and yet in the desertification reverse district, the role of human activities came up to 119.0%, the role of climate change amounted to -19.0%. In addition, the relative role of climate change and human activities possessed great spatial heterogeneity. The above conclusion rather coincides with the qualitative analysis in many literatures, which indicates that this method has certain rationality and can be utilized as a reference for the monitoring and studying of desertification in other areas.

Learning to Change: New Dimensions.

ERIC Educational Resources Information Center

Loughlin, Kathleen

1996-01-01

Change involves thoughts, emotions, values, and actions but thought gets the most attention. Learning to change necessitates an integration of rational and nonrational ways of knowing. Nonrational ways and human care are important dimensions of the learning process. (SK)

A lincRNA connected to cell mortality and epigenetically-silenced in most common human cancers

DOE Office of Scientific and Technical Information (OSTI.GOV)

Vrba, Lukas; Garbe, James C.; Stampfer, Martha R.

Immortality is an essential characteristic of human carcinoma cells. We recently developed an efficient, reproducible method that immortalizes human mammary epithelial cells (HMEC) in the absence of gross genomic changes by targeting 2 critical senescence barriers. Consistent transcriptomic changes associated with immortality were identified using microarray analysis of isogenic normal finite pre-stasis, abnormal finite post-stasis, and immortal HMECs from 4 individuals. A total of 277 genes consistently changed in cells that transitioned from post-stasis to immortal. Gene ontology analysis of affected genes revealed biological processes significantly altered in the immortalization process. These immortalization-associated changes showed striking similarity to the genemore » expression changes seen in The Cancer Genome Atlas (TCGA) clinical breast cancer data. The most dramatic change in gene expression seen during the immortalization step was the downregulation of an unnamed, incompletely annotated transcript that we called MORT, for mortality, since its expression was closely associated with the mortal, finite lifespan phenotype. We show here that MORT (ZNF667-AS1) is expressed in all normal finite lifespan human cells examined to date and is lost in immortalized HMEC. MORT gene silencing at the mortal/immortal boundary was due to DNA hypermethylation of its CpG island promoter. This epigenetic silencing is also seen in human breast cancer cell lines and in a majority of human breast tumor tissues. The functional importance of DNA hypermethylation in MORT gene silencing is supported by the ability of 5-aza-2'- deoxycytidine to reactivate MORT expression. Analysis of TCGA data revealed deregulation of MORT expression due to DNA hypermethylation in 15 out of the 17 most common human cancers. In conclusion, the epigenetic silencing of MORT in a large majority of the common human cancers suggests a potential fundamental role in cellular immortalization during human carcinogenesis.« less

A lincRNA connected to cell mortality and epigenetically-silenced in most common human cancers

DOE PAGES

Vrba, Lukas; Garbe, James C.; Stampfer, Martha R.; ...

2015-10-19

Immortality is an essential characteristic of human carcinoma cells. We recently developed an efficient, reproducible method that immortalizes human mammary epithelial cells (HMEC) in the absence of gross genomic changes by targeting 2 critical senescence barriers. Consistent transcriptomic changes associated with immortality were identified using microarray analysis of isogenic normal finite pre-stasis, abnormal finite post-stasis, and immortal HMECs from 4 individuals. A total of 277 genes consistently changed in cells that transitioned from post-stasis to immortal. Gene ontology analysis of affected genes revealed biological processes significantly altered in the immortalization process. These immortalization-associated changes showed striking similarity to the genemore » expression changes seen in The Cancer Genome Atlas (TCGA) clinical breast cancer data. The most dramatic change in gene expression seen during the immortalization step was the downregulation of an unnamed, incompletely annotated transcript that we called MORT, for mortality, since its expression was closely associated with the mortal, finite lifespan phenotype. We show here that MORT (ZNF667-AS1) is expressed in all normal finite lifespan human cells examined to date and is lost in immortalized HMEC. MORT gene silencing at the mortal/immortal boundary was due to DNA hypermethylation of its CpG island promoter. This epigenetic silencing is also seen in human breast cancer cell lines and in a majority of human breast tumor tissues. The functional importance of DNA hypermethylation in MORT gene silencing is supported by the ability of 5-aza-2'- deoxycytidine to reactivate MORT expression. Analysis of TCGA data revealed deregulation of MORT expression due to DNA hypermethylation in 15 out of the 17 most common human cancers. In conclusion, the epigenetic silencing of MORT in a large majority of the common human cancers suggests a potential fundamental role in cellular immortalization during human carcinogenesis.« less

Detection of cardiac activity changes from human speech

NASA Astrophysics Data System (ADS)

Tovarek, Jaromir; Partila, Pavol; Voznak, Miroslav; Mikulec, Martin; Mehic, Miralem

2015-05-01

Impact of changes in blood pressure and pulse from human speech is disclosed in this article. The symptoms of increased physical activity are pulse, systolic and diastolic pressure. There are many methods of measuring and indicating these parameters. The measurements must be carried out using devices which are not used in everyday life. In most cases, the measurement of blood pressure and pulse following health problems or other adverse feelings. Nowadays, research teams are trying to design and implement modern methods in ordinary human activities. The main objective of the proposal is to reduce the delay between detecting the adverse pressure and to the mentioned warning signs and feelings. Common and frequent activity of man is speaking, while it is known that the function of the vocal tract can be affected by the change in heart activity. Therefore, it can be a useful parameter for detecting physiological changes. A method for detecting human physiological changes by speech processing and artificial neural network classification is described in this article. The pulse and blood pressure changes was induced by physical exercises in this experiment. The set of measured subjects was formed by ten healthy volunteers of both sexes. None of the subjects was a professional athlete. The process of the experiment was divided into phases before, during and after physical training. Pulse, systolic, diastolic pressure was measured and voice activity was recorded after each of them. The results of this experiment describe a method for detecting increased cardiac activity from human speech using artificial neural network.

Climate and demography in early prehistory: using calibrated (14)C dates as population proxies.

PubMed

Riede, Felix

2009-04-01

Although difficult to estimate for prehistoric hunter-gatherer populations, demographic variables-population size, density, and the connectedness of demes-are critical for a better understanding of the processes of material culture change, especially in deep prehistory. Demography is the middle-range link between climatic changes and both biological and cultural evolutionary trajectories of human populations. Much of human material culture functions as a buffer against climatic changes, and the study of prehistoric population dynamics, estimated through changing frequencies of calibrated radiocarbon dates, therefore affords insights into how effectively such buffers operated and when they failed. In reviewing a number of case studies (Mesolithic Ireland, the origin of the Bromme culture, and the earliest late glacial human recolonization of southern Scandinavia), I suggest that a greater awareness of demographic processes, and in particular of demographic declines, provides many fresh insights into what structured the archaeological record. I argue that we cannot sideline climatic and environmental factors or extreme geophysical events in our reconstructions of prehistoric culture change. The implications of accepting demographic variability as a departure point for evaluating the archaeological record are discussed.

Inter-species activity correlations reveal functional correspondences between monkey and human brain areas

PubMed Central

Mantini, Dante; Hasson, Uri; Betti, Viviana; Perrucci, Mauro G.; Romani, Gian Luca; Corbetta, Maurizio; Orban, Guy A.; Vanduffel, Wim

2012-01-01

Evolution-driven functional changes in the primate brain are typically assessed by aligning monkey and human activation maps using cortical surface expansion models. These models use putative homologous areas as registration landmarks, assuming they are functionally correspondent. In cases where functional changes have occurred in an area, this assumption prohibits to reveal whether other areas may have assumed lost functions. Here we describe a method to examine functional correspondences across species. Without making spatial assumptions, we assess similarities in sensory-driven functional magnetic resonance imaging responses between monkey (Macaca mulatta) and human brain areas by means of temporal correlation. Using natural vision data, we reveal regions for which functional processing has shifted to topologically divergent locations during evolution. We conclude that substantial evolution-driven functional reorganizations have occurred, not always consistent with cortical expansion processes. This novel framework for evaluating changes in functional architecture is crucial to building more accurate evolutionary models. PMID:22306809

Impact of Urban Surfaces on Precipitation Processes

NASA Technical Reports Server (NTRS)

Shepherd, J. M.

2004-01-01

The Intergovernmental Panel on Climate Change (IPCC) was established in 1988 by two United Nations organizations, the World Meteorological Organization (WMO) and the United Nations Environment Programme (UNEP) to assess the "risk of human-induced climate change". Such reports are used by decision-makers around the world to assess how our climate is changing. Its reports are widely respected and cited and have been highly influential in forming national and international responses to climate change. The Fourth Assessment report includes a section on the effects of surface processes on climate. This sub-chapter provides an overview of recent developments related to the impact of cities on rainfall. It highlights the possible mechanisms that buildings, urban heat islands, urban aerosols or pollution, and other human factors in cities that can affect rainfall.

An ultra-sensitive biophysical risk assessment of light effect on skin cells.

PubMed

Bennet, Devasier; Viswanath, Buddolla; Kim, Sanghyo; An, Jeong Ho

2017-07-18

The aim of this study was to analyze photo-dynamic and photo-pathology changes of different color light radiations on human adult skin cells. We used a real-time biophysical and biomechanics monitoring system for light-induced cellular changes in an in vitro model to find mechanisms of the initial and continuous degenerative process. Cells were exposed to intermittent, mild and intense (1-180 min) light with On/Off cycles, using blue, green, red and white light. Cellular ultra-structural changes, damages, and ECM impair function were evaluated by up/down-regulation of biophysical, biomechanical and biochemical properties. All cells exposed to different color light radiation showed significant changes in a time-dependent manner. Particularly, cell growth, stiffness, roughness, cytoskeletal integrity and ECM proteins of the human dermal fibroblasts-adult (HDF-a) cells showed highest alteration, followed by human epidermal keratinocytes-adult (HEK-a) cells and human epidermal melanocytes-adult (HEM-a) cells. Such changes might impede the normal cellular functions. Overall, the obtained results identify a new insight that may contribute to premature aging, and causes it to look aged in younger people. Moreover, these results advance our understanding of the different color light-induced degenerative process and help the development of new therapeutic strategies.

A Review of the Foundational Processes that Influence Beliefs in Climate Change: Opportunities for Environmental Education Research

ERIC Educational Resources Information Center

Brownlee, Matthew T.J.; Powell, Robert B.; Hallo, Jeffery C.

2013-01-01

Recently, many organizations involved in environmental education have initiated programs that aim to educate visitors or other publics who interact with nature-based resources about the impacts and landscape transformations occurring because of climatic changes. However, many psychological, human-evolutionary, and social-ecological processes that…

Data-Driven Approaches for Paraphrasing across Language Variations

ERIC Educational Resources Information Center

Xu, Wei

2014-01-01

Our language changes very rapidly, accompanying political, social and cultural trends, as well as the evolution of science and technology. The Internet, especially the social media, has accelerated this process of change. This poses a severe challenge for both human beings and natural language processing (NLP) systems, which usually only model a…

From Performance to Decision Processes in 33 Years: A History of Organizational Behavior and Human Decision Processes under James C. Naylor.

PubMed

Weber

1998-12-01

For the past 33 years, Organizational Behavior and Human Decision Processes has thrived under a single editor. That editor, James C. Naylor, is retiring from his long stewardship. This article chronicles the course of the journal under Jim's direction and marks some of the accomplishments and changes over the past three decades that go to his credit. Copyright 1998 Academic Press.

Climate change: Conflict of observational science, theory, and politics

USGS Publications Warehouse

Gerhard, L.C.

2004-01-01

Debate over whether human activity causes Earth climate change obscures the immensity of the dynamic systems that create and maintain climate on the planet. Anthropocentric debate leads people to believe that they can alter these planetary dynamic systems to prevent that they perceive as negative climate impacts on human civilization. Although politicians offer simplistic remedies, such as the Kyoto Protocol, global climate continues to change naturally. Better planning for the inevitable dislocations that have followed natural global climate changes throughout human history requires us to accept the fact that climate will change, and that human society must adapt to the changes. Over the last decade, the scientific literature reported a shift in emphasis from attempting to build theoretical models of putative human impacts on climate to understanding the planetwide dynamic processes that are the natural climate drivers. The current scientific literature is beginning to report the history of past climate change, the extent of natural climate variability, natural system drivers, and the episodicity of many climate changes. The scientific arguments have broadened from focus upon human effects on climate to include the array of natural phenomena that have driven global climate change for eons. However, significant political issues with long-term social consequences continue their advance. This paper summarizes recent scientific progress in climate science and arguments about human influence on climate. ?? 2004. The American Association of Petroleum Geologists. All rights reserved.

Hands-On! Living in the Biosphere: Production, Pattern, Population, and Diversity. Developing Active Learning Module on the Human Dimensions of Global Change.

ERIC Educational Resources Information Center

Brown, Dwight

Biogeography examines questions of organism inventory and pattern, organisms' interactions with the environment, and the processes that create and change inventory, pattern, and interactions. This learning module uses time series maps and simple simulation models to illustrate how human actions alter biological productivity patterns at local and…

Geographical Applications of Remote Sensing

DOE Office of Scientific and Technical Information (OSTI.GOV)

Weng, Qihao; Zhou, Yuyu; Quattrochi, Dale

2013-02-28

Data and Information derived through Earth observation technology have been extensively used in geographic studies, such as in the areas of natural and human environments, resources, land use and land cover, human-environment interactions, and socioeconomic issues. Land-use and land-cover change (LULCC), affecting biodiversity, climate change, watershed hydrology, and other surface processes, is one of the most important research topics in geography.

Climate Change Vulnerability of Agro-Ecosystems: Does socio-economic factors matters?

NASA Astrophysics Data System (ADS)

Surendran Nair, S.; Preston, B. L.; King, A. W.; Mei, R.; Post, W. M.

2013-12-01

Climate variability and change has direct impacts on agriculture. Despite continual adaptation to climate as well as gains in technology innovation and adoption, agriculture is still vulnerable to changes in temperature and precipitation expected in coming decades. Generally, researchers use two major methodologies to understand the vulnerability of agro-ecosystems to climate change: process-based crop models and empirical models. However, these models are not yet designed to capture the influence of socioeconomic systems on agro-ecosystem processes and outcomes.. However, socioeconomic processes are an important factor driving agro-ecological responses to biophysical processes (climate, topography and soil), because of the role of human agency in mediating the response of agro-ecosystems to climate. We have developed a framework that integrates socioeconomic and biophysical characteristics of agro-ecosystems using cluster analysis and GIS tools. This framework has been applied to the U.S. Southeast to define unique socio-ecological domains for agriculture. The results demonstrate that socioeconomic characteristics are an important factor influencing agriculture production. These results suggest that the lack of attention to socioeconomic conditions and human agency in agro-ecological modeling creates a potential bias with respect to the representation of climate change impacts.

Fragmentation and Isolation

EPA Science Inventory

Landscapes are being modified by humans at ever-increasing rates worldwide. This landscape level modification has resulted in changes in ecological patterns and processes, including species distributions. The rate at which humans are altering both terrestrial and aquatic habitats...

Geomorphology: Perspectives on observation, history, and the field tradition

NASA Astrophysics Data System (ADS)

Vitek, John D.

2013-10-01

Other than a common interest in form and process, current geomorphologists have little in common with those who established the foundations of this science. Educated people who had an interest in Earth processes during the nineteenth century cannot be compared to the scholars who study geomorphology in the twenty-first century. Whereas Earth has undergone natural change from the beginning of time, the human record of observing and recording processes and changes in the surface Is but a recent phenomena. Observation is the only thread, however, that connects all practitioners of geomorphology through time. As people acquired knowledge related to all aspects of life, technological revolutions, such as the Iron Age, Bronze Age, agricultural revolution, the atomic age, and the digital age, shaped human existence and thought. Technology has greatly changed the power of human observation, including inward to the atomic scale and outward into the realm of space.Books and articles describe how to collect and analyze data but few references document the field experience. Each of us, however, has experienced unique circumstances during field work and we learned from various mentors how to observe. The surface of Earth on which we practice the vocation of geomorphology may not be much different from a hundred years ago but many things about how we collect data, analyze it and disseminate the results have changed. How we function in the field, including what we wear, what we eat, how we get there, and where we choose to collect data, clearly reflects the complexity of the human system on Earth and the processes and forms that arouse our interest. Computers, miniaturization of electronics, satellite communications and observation platforms in space provide access to data to aid in our quest to understand Earth surface processes. Once, people lived closer to nature in primitive shelters in contrast with life in urban environments. But as urban life continues to expand and people need to know how Earth operates, geomorphologists, therefore, serve humanity today as the primary observers and reporters in the realm of Earth surface processes.

Description of Changes in Climatic Indices in USA over 25 Years (1989 – 2013)

EPA Science Inventory

The spatial distribution of long-term changes in climatic factors and its relation with vegetation cover, human health, hydrology and many other ecosystem processes help to identify the consequences of climatic factors changes. In recent studies, the significant changes of select...

Global change in the geosphere-biosphere: Initial priorities for an IGBP

NASA Technical Reports Server (NTRS)

1986-01-01

Some of the factors are outlined that leads one to endorse the concept of focused, international geosphere-biosphere program, whose goal is to understand the interactive physical, chemical, and biological processes that regulate the Earth's unique environment for life, the changes that are occurring in this system, and the manner in which they are influenced by human actions. There is a pressing need to assess the consequence of human activities in the context of natural global change and to provide the body of knowledge necessary to chart a wise course to the future. A number of specific objectives were developed which leads to the conclusion that the need for new programs of observation of the Earth as a planet, a better understanding of the interactive processes that governs its changes, the development of a new generation of coupled modes, and the design of suitable tests to guide the development of these models and the understanding of the processes involved. Some general recommendations are summarized.

Face Processing: Models For Recognition

NASA Astrophysics Data System (ADS)

Turk, Matthew A.; Pentland, Alexander P.

1990-03-01

The human ability to process faces is remarkable. We can identify perhaps thousands of faces learned throughout our lifetime and read facial expression to understand such subtle qualities as emotion. These skills are quite robust, despite sometimes large changes in the visual stimulus due to expression, aging, and distractions such as glasses or changes in hairstyle or facial hair. Computers which model and recognize faces will be useful in a variety of applications, including criminal identification, human-computer interface, and animation. We discuss models for representing faces and their applicability to the task of recognition, and present techniques for identifying faces and detecting eye blinks.

Introduction to the special issue on “Understanding and predicting change in the coastal ecosystems of the northern Gulf of Mexico”

USGS Publications Warehouse

Brock, John C.; Barras, John A.; Williams, S. Jeffress

2013-01-01

The coastal region of the northern Gulf of Mexico owes its current landscape structure to an array of tectonic, erosional and depositional, climatic, geochemical, hydrological, ecological, and human processes that have resulted in some of the world's most complex, dynamic, productive, and threatened ecosystems. Catastrophic hurricane landfalls, ongoing subsidence and erosion exacerbated by sea-level rise, disintegration of barrier island chains, and high rates of wetland loss have called attention to the vulnerability of northern Gulf coast ecosystems, habitats, built infrastructure, and economy to natural and anthropogenic threats. The devastating hurricanes of 2005 (Katrina and Rita) motivated the U.S. Geological Survey Coastal and Marine Geology Program and partnering researchers to pursue studies aimed at understanding and predicting landscape change and the associated storm hazard vulnerability of northern Gulf coast region ecosystems and human communities. Attaining this science goal requires increased knowledge of landscape evolution on geologic, historical, and human time scales, and analysis of the implications of such changes in the natural and built components of the landscape for hurricane impact susceptibility. This Special Issue of the Journal of Coastal Research communicates northern Gulf of Mexico research results that (1) improve knowledge of prior climates and depositional environments, (2) assess broad regional ecosystem structure and change over Holocene to human time scales, (3) undertake process studies and change analyses of dynamic landscape components, and (4) integrate framework, climate, variable time and spatial scale mapping, monitoring, and discipline-specific process investigations within interdisciplinary studies.

Clearing the Highest Hurdle: Human-Based Case Studies Broaden Students' Knowledge of Core Evolutionary Concepts

ERIC Educational Resources Information Center

Werth, Alexander J.

2009-01-01

An anonymous survey instrument was used for a ten year study to gauge college student attitudes toward evolution. Results indicate that students are most likely to accept evolution as a historical process for change in physical features of non-human organisms. They are less likely to accept evolution as an ongoing process that shapes all traits…

Introduced Species: Can We Balance Human Systems with Natural Processes? Global Environmental Change Series.

ERIC Educational Resources Information Center

National Science Teachers Association, Arlington, VA.

The seven activities contained in this book are designed to equip students (grades 9-12) with scientific tools and skills for understanding what introduced species are, how they impact natural processes and human systems, and what may be done about them. The activities are designed to link the biology and ecology of introduced species with…

Rethinking schizophrenia in the context of normal neurodevelopment

PubMed Central

Catts, Vibeke S.; Fung, Samantha J.; Long, Leonora E.; Joshi, Dipesh; Vercammen, Ans; Allen, Katherine M.; Fillman, Stu G.; Rothmond, Debora A.; Sinclair, Duncan; Tiwari, Yash; Tsai, Shan-Yuan; Weickert, Thomas W.; Shannon Weickert, Cynthia

2013-01-01

The schizophrenia brain is differentiated from the normal brain by subtle changes, with significant overlap in measures between normal and disease states. For the past 25 years, schizophrenia has increasingly been considered a neurodevelopmental disorder. This frame of reference challenges biological researchers to consider how pathological changes identified in adult brain tissue can be accounted for by aberrant developmental processes occurring during fetal, childhood, or adolescent periods. To place schizophrenia neuropathology in a neurodevelopmental context requires solid, scrutinized evidence of changes occurring during normal development of the human brain, particularly in the cortex; however, too often data on normative developmental change are selectively referenced. This paper focuses on the development of the prefrontal cortex and charts major molecular, cellular, and behavioral events on a similar time line. We first consider the time at which human cognitive abilities such as selective attention, working memory, and inhibitory control mature, emphasizing that attainment of full adult potential is a process requiring decades. We review the timing of neurogenesis, neuronal migration, white matter changes (myelination), and synapse development. We consider how molecular changes in neurotransmitter signaling pathways are altered throughout life and how they may be concomitant with cellular and cognitive changes. We end with a consideration of how the response to drugs of abuse changes with age. We conclude that the concepts around the timing of cortical neuronal migration, interneuron maturation, and synaptic regression in humans may need revision and include greater emphasis on the protracted and dynamic changes occurring in adolescence. Updating our current understanding of post-natal neurodevelopment should aid researchers in interpreting gray matter changes and derailed neurodevelopmental processes that could underlie emergence of psychosis. PMID:23720610

Design for human factors (DfHF): a grounded theory for integrating human factors into production design processes.

PubMed

Village, Judy; Searcy, Cory; Salustri, Filipo; Patrick Neumann, W

2015-01-01

The 'design for human factors' grounded theory explains 'how' human factors (HF) went from a reactive, after-injury programme in safety, to being proactively integrated into each step of the production design process. In this longitudinal case study collaboration with engineers and HF Specialists in a large electronics manufacturer, qualitative data (e.g. meetings, interviews, observations and reflections) were analysed using a grounded theory methodology. The central tenet in the theory is that when HF Specialists acclimated to the engineering process, language and tools, and strategically aligned HF to the design and business goals of the organisation, HF became a means to improve business performance. This led to engineers 'pulling' HF Specialists onto their team. HF targets were adopted into engineering tools to communicate HF concerns quantitatively, drive continuous improvement, visibly demonstrate change and lead to benchmarking. Senior management held engineers accountable for HF as a key performance indicator, thus integrating HF into the production design process. Practitioner Summary: Research and practice lack explanations about how HF can be integrated early in design of production systems. This three-year case study and the theory derived demonstrate how ergonomists changed their focus to align with design and business goals to integrate HF into the design process.

Disruption of the Gut Ecosystem by Antibiotics

PubMed Central

2018-01-01

The intestinal microbiota is a complex ecosystem consisting of various microorganisms that expands human genetic repertoire and therefore affects human health and disease. The metabolic processes and signal transduction pathways of the host and intestinal microorganisms are intimately linked, and abnormal progression of each process leads to changes in the intestinal environment. Alterations in microbial communities lead to changes in functional structures based on the metabolites produced in the gut, and these environmental changes result in various bacterial infections and chronic enteric inflammatory diseases. Here, we illustrate how antibiotics are associated with an increased risk of antibiotic-associated diseases by driving intestinal environment changes that favor the proliferation and virulence of pathogens. Understanding the pathogenesis caused by antibiotics would be a crucial key to the treatment of antibiotic-associated diseases by mitigating changes in the intestinal environment and restoring it to its original state. PMID:29214770

Lessons for the anthropocene from the recent past: Tobacco use, HIV/AIDS, and social transformation

NASA Astrophysics Data System (ADS)

Travis, Charles; Holm, Poul

2017-09-01

In light of the dilemma of global climate change that we have presented ourselves with in the twenty-first century and beyond, many researchers express despair at the ability of humans and societies to change behavior. The paper identifies how global humanity at individual, institutional, and governmental levels have addressed life-threatening dangers in the recent past and begun processes of long-term corrective action. The paper thus discusses global social transformations from the recent past in regards to tobacco use and HIV/AIDS, to think about how Hannah Arendt's concept of the Polis detailed in The Human Condition (1958) may be engaged to address the human dimensions of climate change. As an output of the Andrew W. Mellon European Observatory of the New Human Condition, this paper's focus is commensurate with the thrust of this special issue of Global and Planetary Change which considers climate change to be more of a crisis in the human condition than an environmental problem. Arendt's concept of the Polis provides a framework for a better understanding of change in behavior, preference and motivation. We argue that her perspectives are central to developing multi and inter-disciplinary humanities, social science, science and business perspectives to mobilize collective human action towards adapting to and mitigating the social and environmental threats of global climate change.

Implications of global climate change for housing, human settlements and public health.

PubMed

Hales, Simon; Baker, Michael; Howden-Chapman, Philippa; Menne, Bettina; Woodruff, Rosalie; Woodward, Alistair

2007-01-01

Global climate change has profound implications for human societies. The present---ecologically unsustainable--trajectory of human development fails to provide for the basic needs of a substantial fraction of the global population, while diminishing the prospects for future generations. Human-caused climate change has already begun to affect weather patterns, physical and biological phenomena, and vulnerable human communities. Because the social processes of production and consumption have their own momentum, and because carbon dioxide has a long atmospheric lifetime, further climate change is inevitable over the coming century, even allowing for the adoption of mitigation measures. This situation implies that we should also try to reduce, and where possible to prevent, the adverse effects of climate changes by planned adaptation. Will human settlements be able to provide a healthy living environment and shelter from extreme climate events, such as cyclones and heat waves? In this paper, we review the nexus between human health, climate change, and the planning of housing and human settlements. We conclude that adapting to a rapidly changing global environment will be a major challenge, in the context of increasing population and per capita consumption, without increasing pressures on natural systems. Energy-efficient cities and the creation of opportunities for poor countries will be important elements of people centered, ecologically sustainable, development in the twenty-first century.

A question driven socio-hydrological modeling process

NASA Astrophysics Data System (ADS)

Garcia, M.; Portney, K.; Islam, S.

2016-01-01

Human and hydrological systems are coupled: human activity impacts the hydrological cycle and hydrological conditions can, but do not always, trigger changes in human systems. Traditional modeling approaches with no feedback between hydrological and human systems typically cannot offer insight into how different patterns of natural variability or human-induced changes may propagate through this coupled system. Modeling of coupled human-hydrological systems, also called socio-hydrological systems, recognizes the potential for humans to transform hydrological systems and for hydrological conditions to influence human behavior. However, this coupling introduces new challenges and existing literature does not offer clear guidance regarding model conceptualization. There are no universally accepted laws of human behavior as there are for the physical systems; furthermore, a shared understanding of important processes within the field is often used to develop hydrological models, but there is no such consensus on the relevant processes in socio-hydrological systems. Here we present a question driven process to address these challenges. Such an approach allows modeling structure, scope and detail to remain contingent on and adaptive to the question context. We demonstrate the utility of this process by revisiting a classic question in water resources engineering on reservoir operation rules: what is the impact of reservoir operation policy on the reliability of water supply for a growing city? Our example model couples hydrological and human systems by linking the rate of demand decreases to the past reliability to compare standard operating policy (SOP) with hedging policy (HP). The model shows that reservoir storage acts both as a buffer for variability and as a delay triggering oscillations around a sustainable level of demand. HP reduces the threshold for action thereby decreasing the delay and the oscillation effect. As a result, per capita demand decreases during periods of water stress are more frequent but less drastic and the additive effect of small adjustments decreases the tendency of the system to overshoot available supplies. This distinction between the two policies was not apparent using a traditional noncoupled model.

Science priorities for the human dimensions of global change

NASA Technical Reports Server (NTRS)

1994-01-01

The topics covered include the following: defining research needs; understanding land use change; improving policy analysis -- research on the decision-making process; designing policy instruments and institutions to address energy-related environmental problems; assessing impacts, vulnerability, and adaptation to global changes; and understanding population dynamics and global change.

A Quartet of Change Guides.

ERIC Educational Resources Information Center

Gates, Alan

Since spring 1979 numerous changes in Humanities offerings and operations have been discussed, agreed upon, and implemented at Clark College to revitalize enrollments and increase faculty energy levels. The process of change was based upon four principles: (1) the faculty perceived the need to change, wanted to explore the potential benefits of…

Impact of climate change on human infectious diseases: Empirical evidence and human adaptation.

PubMed

Wu, Xiaoxu; Lu, Yongmei; Zhou, Sen; Chen, Lifan; Xu, Bing

2016-01-01

Climate change refers to long-term shifts in weather conditions and patterns of extreme weather events. It may lead to changes in health threat to human beings, multiplying existing health problems. This review examines the scientific evidences on the impact of climate change on human infectious diseases. It identifies research progress and gaps on how human society may respond to, adapt to, and prepare for the related changes. Based on a survey of related publications between 1990 and 2015, the terms used for literature selection reflect three aspects--the components of infectious diseases, climate variables, and selected infectious diseases. Humans' vulnerability to the potential health impacts by climate change is evident in literature. As an active agent, human beings may control the related health effects that may be effectively controlled through adopting proactive measures, including better understanding of the climate change patterns and of the compound disease-specific health effects, and effective allocation of technologies and resources to promote healthy lifestyles and public awareness. The following adaptation measures are recommended: 1) to go beyond empirical observations of the association between climate change and infectious diseases and develop more scientific explanations, 2) to improve the prediction of spatial-temporal process of climate change and the associated shifts in infectious diseases at various spatial and temporal scales, and 3) to establish locally effective early warning systems for the health effects of predicated climate change. Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.

Effect of cAMP on short-circuit current in isolated human ciliary body.

PubMed

Wu, Ren-yi; Ma, Ning; Hu, Qian-qian

2013-07-01

Cyclic adenosine monophosphate (cAMP) could activate chloride channels in bovine ciliary body and trigger an increase in the ionic current (short-circuit current, Isc) across the ciliary processes in pigs. The purpose of this study was to investigate how cAMP modulates Isc in isolated human ciliary processes and the possible involvement of chloride transport across the tissue in cAMP-induced Isc change. In an Ussing-type chamber system, the Isc changes induced by the cAMP analogue 8-bromo-cAMP and an adenylyl cyclase activator forskolin in isolated human ciliary processes were assessed. The involvement of Cl(-) component in the bath solution was investigated. The effect of Cl(-) channel (10 µmol/L niflumic acid and 1 mmol/L 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid (DIDS)), K(+) channel (10 mmol/L tetraethylammonium chloride (TEA)), or Na(+) channel blockers (1 mmol/L amiloride) on 8-bromo-cAMP-induced Isc change was also studied. Dose-dependently, 8-bromo-cAMP (10 nmol/L-30 µmol/L) or forskolin (10 nmol/L-3 µmol/L) increased Isc across the ciliary processes with an increase in negative potential difference on the non-pigmented epithelium (NPE) side of the tissue. Isc increase induced by 8-bromo-cAMP was more pronounced when the drug was applied on the NPE side than on the pigmented epithelium side. When the tissue was bathed in low Cl(-) solutions, the Isc increase was significantly inhibited. Finally, niflumic acid and DIDS, but not TEA or amiloride, significantly prevented the Isc increase induced by 8-bromo-cAMP. cAMP stimulates stroma-to-aqueous anionic transport in isolated human ciliary processes. Chloride is likely to be among the ions, the transportation of which across the tissue is triggered by cAMP, suggesting the potential role of cAMP in the process of aqueous humor formation in human eyes.

Transgressing the Norm: Transformative Agency in Community-Based Learning for Sustainability in Southern African Contexts

ERIC Educational Resources Information Center

Lotz-Sisitka, Heila; Mukute, Mutizwa; Chikunda, Charles; Baloi, Aristides; Pesanayi, Tichaona

2017-01-01

Environment and sustainability education processes are often oriented to change and transformation, and frequently involve the emergence of new forms of human activity. However, not much is known about how such change emerges from the learning process, or "how" it contributes to the development of transformative agency in community…

Interactions of landscape disturbances and climate change dictate ecological pattern and process: spatial modeling of wildfire, insect, and disease dynamics under future climates

Treesearch

Rachel A. Loehman; Robert E. Keane; Lisa M. Holsinger; Zhiwei Wu

2017-01-01

Context: Interactions among disturbances, climate, and vegetation influence landscape patterns and ecosystem processes. Climate changes, exotic invasions, beetle outbreaks, altered fire regimes, and human activities may interact to produce landscapes that appear and function beyond historical analogs. Objectives We used the mechanistic...

Human Rights Education and the Research Process: Action Research as a Tool for Reflection and Change

ERIC Educational Resources Information Center

Tavares, Celma

2016-01-01

Human rights education (HRE) aims to achieve a change of mindsets and social attitudes that entails the construction of a culture of respect towards those values it teaches. Although HRE is a recent field of study, its consolidation in Latin America is a fact. During the latest decades several authors have carried out research related to HRE that…

Social change, cultural evolution, and human development.

PubMed

Greenfield, Patricia M

2016-04-01

Social change has accelerated globally. Greenfield's interdisciplinary and multilevel theory of social change and human development provides a unified framework for exploring implications of these changes for cultural values, learning environments/socialization processes, and human development/behavior. Data from societies where social change has occurred in place (US, China, and Mexico) and a community where it has occurred through international migration (Mexican immigrants in the US) elucidate these implications. Globally dominant sociodemographic trends are: rural to urban, agriculture to commerce, isolation to interconnectedness, less to more education, less to more technology, lesser to greater wealth, and larger to smaller families/households. These trends lead to both cultural losses (e.g., interdependence/collectivism, respect, tradition, contextualized thinking) and cultural gains (e.g., independence/individualism, equality, innovation, abstraction). Copyright © 2015. Published by Elsevier Ltd.

Report of the panel on the land surface: Process of change, section 5

NASA Technical Reports Server (NTRS)

Adams, John B.; Barron, Eric E.; Bloom, Arthur A.; Breed, Carol; Dohrenwend, J.; Evans, Diane L.; Farr, Thomas T.; Gillespie, Allan R.; Isaks, B. L.; Williams, Richard S.

1991-01-01

The panel defined three main areas of study that are central to the Solid Earth Science (SES) program: climate interactions with the Earth's surface, tectonism as it affects the Earth's surface and climate, and human activities that modify the Earth's surface. Four foci of research are envisioned: process studies with an emphasis on modern processes in transitional areas; integrated studies with an emphasis on long term continental climate change; climate-tectonic interactions; and studies of human activities that modify the Earth's surface, with an emphasis on soil degradation. The panel concluded that there is a clear requirement for global coverage by high resolution stereoscopic images and a pressing need for global topographic data in support of studies of the land surface.

Impacts of climate change on marine organisms and ecosystems.

PubMed

Brierley, Andrew S; Kingsford, Michael J

2009-07-28

Human activities are releasing gigatonnes of carbon to the Earth's atmosphere annually. Direct consequences of cumulative post-industrial emissions include increasing global temperature, perturbed regional weather patterns, rising sea levels, acidifying oceans, changed nutrient loads and altered ocean circulation. These and other physical consequences are affecting marine biological processes from genes to ecosystems, over scales from rock pools to ocean basins, impacting ecosystem services and threatening human food security. The rates of physical change are unprecedented in some cases. Biological change is likely to be commensurately quick, although the resistance and resilience of organisms and ecosystems is highly variable. Biological changes founded in physiological response manifest as species range-changes, invasions and extinctions, and ecosystem regime shifts. Given the essential roles that oceans play in planetary function and provision of human sustenance, the grand challenge is to intervene before more tipping points are passed and marine ecosystems follow less-buffered terrestrial systems further down a spiral of decline. Although ocean bioengineering may alleviate change, this is not without risk. The principal brake to climate change remains reduced CO(2) emissions that marine scientists and custodians of the marine environment can lobby for and contribute to. This review describes present-day climate change, setting it in context with historical change, considers consequences of climate change for marine biological processes now and in to the future, and discusses contributions that marine systems could play in mitigating the impacts of global climate change.

Archaeology as a social science.

PubMed

Smith, Michael E; Feinman, Gary M; Drennan, Robert D; Earle, Timothy; Morris, Ian

2012-05-15

Because of advances in methods and theory, archaeology now addresses issues central to debates in the social sciences in a far more sophisticated manner than ever before. Coupled with methodological innovations, multiscalar archaeological studies around the world have produced a wealth of new data that provide a unique perspective on long-term changes in human societies, as they document variation in human behavior and institutions before the modern era. We illustrate these points with three examples: changes in human settlements, the roles of markets and states in deep history, and changes in standards of living. Alternative pathways toward complexity suggest how common processes may operate under contrasting ecologies, populations, and economic integration.

Optical pre-clinical diagnostics of the cervical tissues malignant changing

NASA Astrophysics Data System (ADS)

Yermolenko, Sergey; Voloshynskyi, Dmytro; Fedoruk, Olexander; Gruia, Ion; Zimnyakov, Dmitry

2014-08-01

This work is directed to the investigation of the scope of the technique of laser polarimetry of oncological changes of the human prostate and cervical tissues under the conditions of multiple scattering, which presents a more general and real experimental clinical situation. This study is combining polarimetry and spectropolarimetry techniques for identifying the changes of optical-geometrical structure in different kinds of biotissues with solid tumours. It is researched that a linear dichroism appears in biotissues (human esophagus, muscle tissue of rats, human prostate tissue, cervical smear) with cancer diseases, magnitude of which depends on the type of the tissue and on the time of cancer process development.

Archaeology as a social science

PubMed Central

Smith, Michael E.; Feinman, Gary M.; Drennan, Robert D.; Earle, Timothy; Morris, Ian

2012-01-01

Because of advances in methods and theory, archaeology now addresses issues central to debates in the social sciences in a far more sophisticated manner than ever before. Coupled with methodological innovations, multiscalar archaeological studies around the world have produced a wealth of new data that provide a unique perspective on long-term changes in human societies, as they document variation in human behavior and institutions before the modern era. We illustrate these points with three examples: changes in human settlements, the roles of markets and states in deep history, and changes in standards of living. Alternative pathways toward complexity suggest how common processes may operate under contrasting ecologies, populations, and economic integration. PMID:22547811

How can climate change and engineered water conveyance affect sediment dynamics in the San Francisco Bay-Delta system?

USGS Publications Warehouse

Achete, Fernanda; Van der Wegen, Mick; Roelvink, Jan Adriaan; Jaffe, Bruce E.

2017-01-01

Suspended sediment concentration is an important estuarine health indicator. Estuarine ecosystems rely on the maintenance of habitat conditions, which are changing due to direct human impact and climate change. This study aims to evaluate the impact of climate change relative to engineering measures on estuarine fine sediment dynamics and sediment budgets. We use the highly engineered San Francisco Bay-Delta system as a case study. We apply a process-based modeling approach (Delft3D-FM) to assess the changes in hydrodynamics and sediment dynamics resulting from climate change and engineering scenarios. The scenarios consider a direct human impact (shift in water pumping location), climate change (sea level rise and suspended sediment concentration decrease), and abrupt disasters (island flooding, possibly as the results of an earthquake). Levee failure has the largest impact on the hydrodynamics of the system. Reduction in sediment input from the watershed has the greatest impact on turbidity levels, which are key to primary production and define habitat conditions for endemic species. Sea level rise leads to more sediment suspension and a net sediment export if little room for accommodation is left in the system due to continuous engineering works. Mitigation measures like levee reinforcement are effective for addressing direct human impacts, but less effective for a persistent, widespread, and increasing threat like sea level rise. Progressive adaptive mitigation measures to the changes in sediment and flow dynamics resulting from sea level rise may be a more effective strategy. Our approach shows that a validated process-based model is a useful tool to address long-term (decades to centuries) changes in sediment dynamics in highly engineered estuarine systems. In addition, our modeling approach provides a useful basis for long-term, process-based studies addressing ecosystem dynamics and health.

Mosaic evolution and the pattern of transitions in the hominin lineage

PubMed Central

Foley, Robert A.

2016-01-01

Humans are uniquely unique, in terms of the extreme differences between them and other living organisms, and the impact they are having on the biosphere. The evolution of humans can be seen, as has been proposed, as one of the major transitions in evolution, on a par with the origins of multicellular organisms or the eukaryotic cell (Maynard Smith & Szathmáry 1997 Major transitions in evolution). Major transitions require the evolution of greater complexity and the emergence of new evolutionary levels or processes. Does human evolution meet these conditions? I explore the diversity of evidence on the nature of transitions in human evolution. Four levels of transition are proposed—baseline, novel taxa, novel adaptive zones and major transitions—and the pattern of human evolution considered in the light of these. The primary conclusions are that changes in human evolution occur continuously and cumulatively; that novel taxa and the appearance of new adaptations are not clustered very tightly in particular periods, although there are three broad transitional phases (Pliocene, Plio-Pleistocene and later Quaternary). Each phase is distinctive, with the first based on ranging and energetics, the second on technology and niche expansion, and the third on cognition and cultural processes. I discuss whether this constitutes a ‘major transition’ in the context of the evolutionary processes more broadly; the role of behaviour in evolution; and the opportunity provided by the rich genetic, phenotypic (fossil morphology) and behavioural (archaeological) record to examine in detail major transitions and the microevolutionary patterns underlying macroevolutionary change. It is suggested that the evolution of the hominin lineage is consistent with a mosaic pattern of change. This article is part of the themed issue ‘Major transitions in human evolution’. PMID:27298474

Mosaic evolution and the pattern of transitions in the hominin lineage.

PubMed

Foley, Robert A

2016-07-05

Humans are uniquely unique, in terms of the extreme differences between them and other living organisms, and the impact they are having on the biosphere. The evolution of humans can be seen, as has been proposed, as one of the major transitions in evolution, on a par with the origins of multicellular organisms or the eukaryotic cell (Maynard Smith & Szathmáry 1997 Major transitions in evolution). Major transitions require the evolution of greater complexity and the emergence of new evolutionary levels or processes. Does human evolution meet these conditions? I explore the diversity of evidence on the nature of transitions in human evolution. Four levels of transition are proposed-baseline, novel taxa, novel adaptive zones and major transitions-and the pattern of human evolution considered in the light of these. The primary conclusions are that changes in human evolution occur continuously and cumulatively; that novel taxa and the appearance of new adaptations are not clustered very tightly in particular periods, although there are three broad transitional phases (Pliocene, Plio-Pleistocene and later Quaternary). Each phase is distinctive, with the first based on ranging and energetics, the second on technology and niche expansion, and the third on cognition and cultural processes. I discuss whether this constitutes a 'major transition' in the context of the evolutionary processes more broadly; the role of behaviour in evolution; and the opportunity provided by the rich genetic, phenotypic (fossil morphology) and behavioural (archaeological) record to examine in detail major transitions and the microevolutionary patterns underlying macroevolutionary change. It is suggested that the evolution of the hominin lineage is consistent with a mosaic pattern of change.This article is part of the themed issue 'Major transitions in human evolution'. © 2016 The Author(s).

Studying Biological Rhythms of Person's Skin-galvanic Reaction and Dynamics of Light Transmission by Isomeric Substance in Space Flight Conditions

NASA Technical Reports Server (NTRS)

Glushko, Vladimir

2004-01-01

Intensity and amplitude of human functional systems and human most important organs are wavelike, rhythmic by nature. These waves have constant periodicity, phase and amplitude. The mentioned characteristics can vary, however their variations have a pronounced reiteration in the course of time. This indicates a hashing of several wave processes and their interference. Stochastic changes in wave processes characteristics of a human organism are explained either by 'pulsations' associated with hashing (superposition) of several wave processes and their interference, or by single influence of environmental physical factors on a human organism. Human beings have respectively periods of higher and lower efficiency, state of health and so on, depending not only of environmental factors, but also of 'internal' rhythmic factor. Sometimes peaks and falls periodicity of some or other characteristics is broken. Disturbance of steady-state biological rhythms is usually accompanied by reduction of activity steadiness of the most important systems of a human organism. In its turn this has an effect on organism's adaptation to changing living conditions as well as on general condition and efficiency of a human being. The latter factor is very important for space medicine. Biological rhythmology is a special branch of biology and medicine, it studies rhythmic activity mechanisms of organs, their systems, individuals and species. Appropriate researches were also carried out in space medicine.

[Factors of success in the implementation of the technologies of the information and the communication in the health systems. The human factor].

PubMed

Roman-Viñas, Ramón

2010-02-01

In this work some of the fundamentals of change management techniques to ensure the introduction of information and communication technologies in health organizations are analized. Managing change is aimed at redirecting the impact of any transformation process in the organizations towards a positive attitude and enthusiasm of those involved. That is, this paper analyzes the most important of all factors that must be managed in any project for change: the human factor. If a proper change management is a critical success factor in implementing new processes and systems of information and communication technologies (ICT) in an organization, when we faced with the introduction of new processes and interoperability systems between different organizations, cooperation, leadership and motivation of individuals focused on a common goal is absolutely imperative. This is the case of the new ICT systems being introduced in the Catalan Health System. Indeed, by definition of the model itself, in Catalonia, continuity of care, increased efficiency and effectiveness and quality improvement of projects as the clinical history shared, electronic prescriptions, or scanning medical imaging, require necessarily the definition of processes in which a large number of different health organizations, different in their law status, and whose own interests should converge towards the ICT systems and processes of health care so that the contribution of all parties can make a whole. The success of these projects, a reality nowadays, is due largely to the management of the human factor conducted continuously since its inception. 2010 Elsevier España S.L. All rights reserved.

The topographic signature of anthropogenic geomorphic processes

NASA Astrophysics Data System (ADS)

Tarolli, P.; Sofia, G.

2014-12-01

Within an abiotic-dominated context, geomorphologic patterns and dynamics are single expressions of trade-offs between the physical resistance forces, and the mechanical and chemical forces related to climate and erosion. Recently, however, it has become essential for the geomorphological community to take into account also biota as a fundamental geomorphologic agent acting from local to regional scales. However, while there is a recent flourishing literature about the impacts of vegetation on geomorphic processes, the study of anthropogenic pressure on geomorphology is still at its early stages. Humans are indeed among the most prominent geomorphic agents, redistributing land surface, and causing drastic changes to the geomorphic organization of the landscape (e.g. intensive agriculture, urbanization), with direct consequences on land degradation and watershed response. The reconstruction or identification of artificial or anthropogenic topographies, therefore, provides a mechanism for quantifying anthropogenic changes to the landscape systems in the context of the Anthropocene epoch. High-resolution topographic data derived from the recent remote sensing technologies (e.g. lidar, SAR, SfM), offer now new opportunities to recognize better understand geomorphic processes from topographic signatures, especially in engineered landscapes where the direct anthropic alteration of processes is significant. It is possible indeed to better recognize human-induced geomorphic and anthropogenic features (e.g. road networks, agricultural terraces), and the connected erosion. The study presented here may allow improved understanding and targeted mitigation of the processes driving geomorphic changes during urban development and help guide future research directions for development-based watershed studies. Human society is deeply affecting the environment with consequences on the landscape. It is therefore fundamental to establish greater management control over the Earth's rapidly changing ecosystems. Tarolli, P. (2014). High-resolution topography for understanding Earth surface processes: opportunities and challenges, Geomorphology, 216, 295-312, doi:10.1016/j.geomorph.2014.03.008.

Physiological changes in neurodegeneration - mechanistic insights and clinical utility.

PubMed

Ahmed, Rebekah M; Ke, Yazi D; Vucic, Steve; Ittner, Lars M; Seeley, William; Hodges, John R; Piguet, Olivier; Halliday, Glenda; Kiernan, Matthew C

2018-05-01

The effects of neurodegenerative syndromes extend beyond cognitive function to involve key physiological processes, including eating and metabolism, autonomic nervous system function, sleep, and motor function. Changes in these physiological processes are present in several conditions, including frontotemporal dementia, amyotrophic lateral sclerosis, Alzheimer disease and the parkinsonian plus conditions. Key neural structures that mediate physiological changes across these conditions include neuroendocrine and hypothalamic pathways, reward pathways, motor systems and the autonomic nervous system. In this Review, we highlight the key changes in physiological processing in neurodegenerative syndromes and the similarities in these changes between different progressive neurodegenerative brain conditions. The changes and similarities between disorders might provide novel insights into the human neural correlates of physiological functioning. Given the evidence that physiological changes can arise early in the neurodegenerative process, these changes could provide biomarkers to aid in the early diagnosis of neurodegenerative diseases and in treatment trials.

Contemporary post-humanism: technological and human singularity.

PubMed

Colombetti, Elena

2014-01-01

Posthumanism entails the idea of transcendence of the human being achieved through technology. The article begins by distinguishing perfection and change (or growth). It also attempts to show the anthropological premises of posthumanism itself and suggests that we can identify two roots: the liberal humanistic subject (autonomous and unrelated that simply realizes herself/himself through her/his own project) and the interpretation of thought as a computable process. Starting from these premises, many authors call for the loosening of the clear boundaries of one's own subject in favour of blending with other beings. According to these theories, we should become post-human: if the human being is thought and thought is a computable process, whatever is able to process information broader and faster is better than the actual human being and has to be considered as the way towards the real completeness of the human being itself. The paper endeavours to discuss the adequacy of these premises highlighting the structural dependency of the human being, the role of the human body, the difference between thought and a computational process, the singularity of some useless and unexpected human acts. It also puts forward the need for axiological criteria to define growth as perfectionism.

Neurophysiological Factors in Human Information Processing Capacity

ERIC Educational Resources Information Center

Ramsey, Nick F.; Jansma, J. M.; Jager, G.; Van Raalten, T.; Kahn, R. S.

2004-01-01

What determines how well an individual can manage the complexity of information processing demands when several tasks have to be executed simultaneously? Various theoretical frameworks address the mechanisms of information processing and the changes that take place when processes become automated, and brain regions involved in various types of…

Climate Change, Soils, and Human Health

NASA Astrophysics Data System (ADS)

Brevik, Eric C.

2013-04-01

According to the Intergovernmental Panel on Climate Change, global temperatures are expected to increase 1.1 to 6.4 degrees C during the 21st century and precipitation patterns will be altered by climate change (IPCC, 2007). Soils are intricately linked to the atmospheric/climate system through the carbon, nitrogen, and hydrologic cycles. Altered climate will, therefore, have an effect on soil processes and properties. Studies into the effects of climate change on soil processes and properties are still incomplete, but have revealed that climate change will impact soil organic matter dynamics including soil organisms and the multiple soil properties that are tied to organic matter, soil water, and soil erosion. The exact direction and magnitude of those impacts will be dependent on the amount of change in atmospheric gases, temperature, and precipitation amounts and patterns. Recent studies give reason to believe at least some soils may become net sources of atmospheric carbon as temperatures rise; this is particularly true of high latitude regions with permanently frozen soils. Soil erosion by both wind and water is also likely to increase. These soil changes will lead to both direct and indirect impacts on human health. Possible indirect impacts include temperature extremes, food safety and air quality issues, increased and/or expanded disease incidences, and occupational health issues. Potential direct impacts include decreased food security and increased atmospheric dust levels. However, there are still many things we need to know more about. How climate change will affect the nitrogen cycle and, in turn, how the nitrogen cycle will affect carbon sequestration in soils is a major research need, as is a better understanding of soil water-CO2 level-temperature relationships. Knowledge of the response of plants to elevated atmospheric CO2 given limitations in nutrients like nitrogen and phosphorus and how that affects soil organic matter dynamics is a critical need. There is also a great need for a better understanding of how soil organisms will respond to climate change because those organisms are incredibly important in a number of soil processes, including the carbon and nitrogen cycles. All of these questions are important in trying to understand human health impacts. More information on climate change, soils, and human health issues can be found in Brevik (2012). References Brevik, E.C. 2012. Climate change, soils, and human health. In: E.C. Brevik and L. Burgess (Eds). Soils and human health. CRC Press, Boca Raton, FL. in press. IPCC. 2007. Summary for policymakers. pp. 1-18. In S. Solomon, D. Qin, M. Manning, Z. Chen, M. Marquis, K.B. Averyt, M.Tignor and H.L. Miller (eds). Climate change 2007: the physical science basis. Contribution of Working Group I to the Fourth Assessment Report of the Intergovernmental Panel on Climate Change. Cambridge University Press, Cambridge, UK.

Plants, arthropods, and birds of the Rio Grande [chapter 7

Treesearch

Deborah M. Finch; Gale L. Wolters; Wang Yong; Mary Jean Mund

1995-01-01

Human populations have increased dramatically along the Rio Grande since European settlement. Human use of water for irrigation and consumption, and human use of land for agriculture, urban centers, livestock grazing, and recreation have changed Rio Grande ecosystems by altering flood cycles, channel geomorphology, upslope processes, and water quality and quantity....

Hydrological effects of cropland and climatic changes in arid and semi-arid river basins: A case study from the Yellow River basin, China

NASA Astrophysics Data System (ADS)

Li, Huazhen; Zhang, Qiang; Singh, Vijay P.; Shi, Peijun; Sun, Peng

2017-06-01

The Yellow River basin is a typical semi-arid river basin in northern China. Serious water shortages have negative impacts on regional socioeconomic development. Recent years have witnessed changes in streamflow processes due to increasing human activities, such as agricultural activities and construction of dams and water reservoirs, and climatic changes, e.g. precipitation and temperature. This study attempts to investigate factors potentially driving changes in different streamflow components defined by different quantiles. The data used were daily streamflow data for the 1959-2005 period from 5 hydrological stations, daily precipitation and temperature data from 77 meteorological stations and data pertaining to cropland and large reservoirs. Results indicate a general decrease in streamflow across the Yellow River basin. Moreover significant decreasing streamflow has been observed in the middle and lower Yellow River basin with change points during the mid-1980s till the mid-1990s. The changes of cropland affect the streamflow components and also the cumulative effects on streamflow variations. Recent years have witnessed moderate cropland variations which result in moderate streamflow changes. Further, precipitation also plays a critical role in changes of streamflow components and human activities, i.e. cropland changes, temperature changes and building of water reservoirs, tend to have increasing impacts on hydrological processes across the Yellow River basin. This study provides a theoretical framework for the study of the hydrological effects of human activities and climatic changes on basins over the globe.

Natural vs. Human forcing: the new challenge for the Earth science community in the Anthropocene

NASA Astrophysics Data System (ADS)

Tarolli, Paolo

2014-05-01

From the analysis of Earth surface, we are able to learn a lot about its history and processes. Indeed, different landforms bear the signs of different ages, but also of climate and tectonic forcing. In addition to these processes, also the biota forcing has a role in shaping the landscape, of course at different scale and magnitude if compared with geology. In biotic landscapes the vegetation through the roots influences the soil formation and surface erosion. Biota affect also climate, and as a consequence the mechanisms and erosion rates that control the landscape evolution. However, the question is, if we can suppose that there is an evidence of biota forcing, what is the role of humans? Human activities, more than vegetation, are leaving a significant signature on the Earth, by altering its morphology and ecosystems. Also in this case, the temporal and spatial scale (and also the magnitude) are different respect to geological forcing, but the development of the society during the Holocene was significant (from hunting-gathering to farming to complex societies and metropolis): the increase of the population was related to a progressively increase of intensive agriculture and urbanization. This anthropogenic forcing deeply affected the environment, inducing or reducing erosion, and changing the equilibrium of several ecosystems. The recognition and the analysis of the human induced changes, signatures and processes represent a real challenge for the scientific community to better understand the evolution of our Planet. This analysis can help in scheduling a suitable environmental planning for a sustainable development, and to mitigate the consequences of anthropogenic alteration. Wider multidisciplinary groups based on these studies could be able to understand better the evolution of landscapes and ecosystems during the human era, providing a full dataset of multidisciplinary information that can be used by land managers and local authorities, and by the scientific community as well. The recent remotely sensed technologies (e.g. LIDAR, SAR, SfM) might help to reach part of the mentioned goals. High-resolution topography could really play a strategic and helpful role in the recognition of human-induced geomorphic and anthropogenic features, and the connected erosion. Among the most evident landscape signatures of the human fingerprint, for example, road networks and agricultural practices such as terracing deserve a great importance since significantly affect the erosional processes. A better recognition of these signatures is at the basis to improve the knowledge of the related induced processes. In addition to this, it is necessary to improve, through historical data (e.g. hydrogeological, meteorological, stratigraphy, also archeological data) and modeling, the understanding about the land use changes occurred during the last centuries, focusing on the reasoning behind these changes, and on the analysis of their effects on landscape and processes. Human society relies on the vast diversity of benefits provided by the environment. Soil biodiversity and conservation are part of the driving force behind its regulation. At the same time, human society is deeply affecting the environment with consequences on the landscape. It is therefore fundamental to establish greater management control over the Earth's rapidly changing ecosystems.

Implications of global climate change for the assessment and management of human health risks of chemicals in the natural environment.

PubMed

Balbus, John M; Boxall, Alistair B A; Fenske, Richard A; McKone, Thomas E; Zeise, Lauren

2013-01-01

Global climate change (GCC) is likely to alter the degree of human exposure to pollutants and the response of human populations to these exposures, meaning that risks of pollutants could change in the future. The present study, therefore, explores how GCC might affect the different steps in the pathway from a chemical source in the environment through to impacts on human health and evaluates the implications for existing risk-assessment and management practices. In certain parts of the world, GCC is predicted to increase the level of exposure of many environmental pollutants due to direct and indirect effects on the use patterns and transport and fate of chemicals. Changes in human behavior will also affect how humans come into contact with contaminated air, water, and food. Dietary changes, psychosocial stress, and coexposure to stressors such as high temperatures are likely to increase the vulnerability of humans to chemicals. These changes are likely to have significant implications for current practices for chemical assessment. Assumptions used in current exposure-assessment models may no longer apply, and existing monitoring methods may not be robust enough to detect adverse episodic changes in exposures. Organizations responsible for the assessment and management of health risks of chemicals therefore need to be more proactive and consider the implications of GCC for their procedures and processes. Copyright © 2012 SETAC.

Towards environmentally sustainable human behaviour: targeting non-conscious and conscious processes for effective and acceptable policies

NASA Astrophysics Data System (ADS)

Marteau, Theresa M.

2017-05-01

Meeting climate change targets to limit global warming to 2°C requires rapid and large reductions in demand for products that most contribute to greenhouse gas (GHG) emissions. These include production of bulk materials (e.g. steel and cement), energy supply (e.g. fossil fuels) and animal source foods (particularly ruminants and their products). Effective strategies to meet these targets require transformative changes in supply as well as demand, involving changes in economic, political and legal systems at local, national and international levels, building on evidence from many disciplines. This paper outlines contributions from behavioural science in reducing demand. Grounded in dual-process models of human behaviour (involving non-conscious and conscious processes) this paper considers first why interventions aimed at changing population values towards the environment are usually insufficient or unnecessary for reducing demand although they may be important in increasing public acceptability of policies that could reduce demand. It then outlines two sets of evidence from behavioural science towards effective systems-based strategies, to identify interventions likely to be effective at: (i) reducing demand for products that contribute most to GHG emissions, mainly targeting non-conscious processes and (ii) increasing public acceptability for policy changes to enable these interventions, targeting conscious processes. This article is part of the themed issue 'Material demand reduction'.

Towards environmentally sustainable human behaviour: targeting non-conscious and conscious processes for effective and acceptable policies.

PubMed

Marteau, Theresa M

2017-06-13

Meeting climate change targets to limit global warming to 2°C requires rapid and large reductions in demand for products that most contribute to greenhouse gas (GHG) emissions. These include production of bulk materials (e.g. steel and cement), energy supply (e.g. fossil fuels) and animal source foods (particularly ruminants and their products). Effective strategies to meet these targets require transformative changes in supply as well as demand, involving changes in economic, political and legal systems at local, national and international levels, building on evidence from many disciplines. This paper outlines contributions from behavioural science in reducing demand. Grounded in dual-process models of human behaviour (involving non-conscious and conscious processes) this paper considers first why interventions aimed at changing population values towards the environment are usually insufficient or unnecessary for reducing demand although they may be important in increasing public acceptability of policies that could reduce demand. It then outlines two sets of evidence from behavioural science towards effective systems-based strategies, to identify interventions likely to be effective at: (i) reducing demand for products that contribute most to GHG emissions, mainly targeting non-conscious processes and (ii) increasing public acceptability for policy changes to enable these interventions, targeting conscious processes.This article is part of the themed issue 'Material demand reduction'. © 2017 The Authors.

Towards environmentally sustainable human behaviour: targeting non-conscious and conscious processes for effective and acceptable policies

PubMed Central

2017-01-01

Meeting climate change targets to limit global warming to 2°C requires rapid and large reductions in demand for products that most contribute to greenhouse gas (GHG) emissions. These include production of bulk materials (e.g. steel and cement), energy supply (e.g. fossil fuels) and animal source foods (particularly ruminants and their products). Effective strategies to meet these targets require transformative changes in supply as well as demand, involving changes in economic, political and legal systems at local, national and international levels, building on evidence from many disciplines. This paper outlines contributions from behavioural science in reducing demand. Grounded in dual-process models of human behaviour (involving non-conscious and conscious processes) this paper considers first why interventions aimed at changing population values towards the environment are usually insufficient or unnecessary for reducing demand although they may be important in increasing public acceptability of policies that could reduce demand. It then outlines two sets of evidence from behavioural science towards effective systems-based strategies, to identify interventions likely to be effective at: (i) reducing demand for products that contribute most to GHG emissions, mainly targeting non-conscious processes and (ii) increasing public acceptability for policy changes to enable these interventions, targeting conscious processes. This article is part of the themed issue ‘Material demand reduction’. PMID:28461435

An Analytic Equation Partitioning Climate Variation and Human Impacts on River Sediment Load

NASA Astrophysics Data System (ADS)

Zhang, J.; Gao, G.; Fu, B.

2017-12-01

Spatial or temporal patterns and process-based equations could co-exist in hydrologic model. Yet, existing approaches quantifying the impacts of those variables on river sediment load (RSL) changes are found to be severely limited, and new ways to evaluate the contribution of these variables are thus needed. Actually, the Newtonian modeling is hardly achievable for this process due to the limitation of both observations and knowledge of mechanisms, whereas laws based on the Darwinian approach could provide one component of a developed hydrologic model. Since that streamflow is the carrier of suspended sediment, sediment load changes are documented in changes of streamflow and suspended sediment concentration (SSC) - water discharge relationships. Consequently, an analytic equation for river sediment load changes are proposed to explicitly quantify the relative contributions of climate variation and direct human impacts on river sediment load changes. Initially, the sediment rating curve, which is of great significance in RSL changes analysis, was decomposed as probability distribution of streamflow and the corresponding SSC - water discharge relationships at equally spaced discharge classes. Furthermore, a proposed segmentation algorithm based on the fractal theory was used to decompose RSL changes attributed to these two portions. Additionally, the water balance framework was utilized and the corresponding elastic parameters were calculated. Finally, changes in climate variables (i.e. precipitation and potential evapotranspiration) and direct human impacts on river sediment load could be figured out. By data simulation, the efficiency of the segmentation algorithm was verified. The analytic equation provides a superior Darwinian approach partitioning climate and human impacts on RSL changes, as only data series of precipitation, potential evapotranspiration and SSC - water discharge are demanded.

Tree physiology research in a changing world.

PubMed

Kaufmann, Merrill R.; Linder, Sune

1996-01-01

Changes in issues and advances in methodology have contributed to substantial progress in tree physiology research during the last several decades. Current research focuses on process interactions in complex systems and the integration of processes across multiple spatial and temporal scales. An increasingly important challenge for future research is assuring sustainability of production systems and forested ecosystems in the face of increased demands for natural resources and human disturbance of forests. Meeting this challenge requires significant shifts in research approach, including the study of limitations of productivity that may accompany achievement of system sustainability, and a focus on the biological capabilities of complex land bases altered by human activity.

Long-term watershed research and monitoring to understand ecosystem change in parks and equivalent reserves

USGS Publications Warehouse

Herrmann, R.

1997-01-01

Integrated watershed ecosystem studies in National Parks or equivalent reserves suggest that effects of external processes on 'protected' resources are subtle, chronic, and long-term. Ten years of data from National Park watersheds suggests that temperature and precipitation changes are linked to nitrogen levels in lakes and streams. We envision measurable biotic effects in these remote watersheds, if expected climate trends continue. The condition of natural resources within areas set aside for preservation are difficult to ascertain, but gaining this knowledge is the key to understanding ecosystem change and of processes operating among biotic and abiotic ecosystem components. There is increasing evidence that understanding the magnitude of variation within and between such processes can provide an early indication of environmental change and trends attributable to human-induced stress. The following four papers are case studies of how this concept has been implemented. These long-term studies have expanded our knowledge of ecosystem response to natural and human-induced stress. The existence of these sites with a commitment to gathering 'long-term' ecosystem-level data permits research activities aimed at testing more important hypotheses on ecosystem processes and structure.

Confocal Raman study of aging process in diabetes mellitus human voluntaries

NASA Astrophysics Data System (ADS)

Pereira, Liliane; Téllez Soto, Claudio Alberto; dos Santos, Laurita; Ali, Syed Mohammed; Fávero, Priscila Pereira; Martin, Airton A.

2015-06-01

Accumulation of AGEs [Advanced Glycation End - products] occurs slowly during the human aging process. However, its formation is accelerated in the presence of diabetes mellitus. In this paper, we perform a noninvasive analysis of glycation effect on human skin by in vivo confocal Raman spectroscopy. This technique uses a laser of 785 nm as excitation source and, by the inelastic scattering of light, it is possible to obtain information about the biochemical composition of the skin. Our aim in this work was to characterize the aging process resulting from the glycation process in a group of 10 Health Elderly Women (HEW) and 10 Diabetic Elderly Women (DEW). The Raman data were collected from the dermis at a depth of 70-130 microns. Through the theory of functional density (DFT) the bands positions of hydroxyproline, proline and AGEs (pentosidine and glucosepane) were calculated by using Gaussian 0.9 software. A molecular interpretation of changes in type I collagen was performed by the changes in the vibrational modes of the proline (P) and hydroxyproline (HP). The data analysis shows that the aging effects caused by glycation of proteins degrades type I collagen differently and leads to accelerated aging process.

Career Education for Mental Health Workers. Integrative Seminar in Human Service. Human Service Instructional Series. Module No. 5.

ERIC Educational Resources Information Center

Redcay, Shirley

This module on an integrative seminar in human service is one of a set of six developed to prepare human services workers for the changing mental health service delivery system. A total of eight objectives are included to help students integrate previously learned knowledge and skills into a process of assessing service need, developing treatment…

Detection of Hydrological changes of Wujiang River

NASA Astrophysics Data System (ADS)

Dong, L.; Chen, Y.

2016-12-01

In the century our earth experienced a rapid environment changes due to strong human activities, which impactedthe earth'shydrology and water resources systems negatively, and causedsevere problems to the society, such as increased flood and drought risk, water pollution and ecosystem degradation. Understanding the variations of hydrological characteristics has important meaning to solve the problem of hydrology and water resources and maintain sustainable development of river basin water resources.This paper takesWujiangriveras an example,which is a typical medium watershedaffected by human activities seriously in southern China.Using the methods of Mann-Kendall test and serial cluster analysis, this paper studies the characteristics and laws of historical hydrological process inWujiang river, detectsthe impact of changing environment to watershed hydrological processes, based on the observed hydrological data of 36 years from 1980 to 2015 in three representative hydrological stationsnamedFenshi,Chixi and Pingshi. The results show that the annual runoffandannual precipitation has some kind of changes.

Human-induced geomorphic change across environmental gradients

NASA Astrophysics Data System (ADS)

Vanacker, V.; Molina, A.; Bellin, N.; Christl, M.

2016-12-01

Human-induced land cover changes are causing important adverse effects on the ecological services rendered by mountain ecosystems, and the number of case-studies of the impact of humans on soil erosion and sediment yield has mounted rapidly. Anthropogenic disturbance of natural vegetation can profoundly alter the physical, chemical and biological processes within soils. Rapid removal of topsoil during intense farming can result in an imbalance between soil production through chemical weathering and physical soil erosion, with direct implications on nutrient cycling, soil fertility and agricultural production. In this study, we present a conceptual model for assessing human-induced erosion for a wide variety of environmental settings and pose that human-induced geomorphic change cannot be assessed solely based on modern erosion rates as natural or baseline erosion rates can be important in e.g. mountainous terrain. As such, we assess the vulnerability of a given ecosystem to human-induced land cover change by quantifying the change in catchment-wide erosion rates resulting from anthropogenic changes in vegetation cover. Human-induced erosion is here approximated by the ratio of the total specific sediment yield to the natural erosional mass flux, and is dimensionless. The conceptual model is applied to three contrasting environmental settings where data on soil production, physical soil erosion and long-term denudation are available: the tropical Andes, subtropical southern Brazil, and semi-arid Spanish Cordillera. The magnitude of human-induced geomorphic change strongly differs between the three regions. The data suggest that the sensitivity to human-induced erosion is ecosystem dependent, and related to soil erosivity and potential vegetation cover disturbances as a result of human impact. It may therefore be expected that the potential for erosion regulation is larger in well-vegetated ecosystem where strong differences may exist in vegetation cover between human disturbed and undisturbed or restored sites.

Catchment sediment flux: a lake sediment perspective on the onset of the Anthropocene?

NASA Astrophysics Data System (ADS)

Chiverrell, Richard

2014-05-01

Definitions of the Anthropocene are varied but from a geomorphological perspective broadly can be described as the interval of recent Earth history during which 'humans have had an 'overwhelming' effect on the Earth system' (Brown et al., 2013). Identifying the switch to a human-dominated geomorphic process regime is actually a challenging process, with in the 'Old World' ramping up of human populations and impacts on earth surface processes since the Neolithic/Mesolithic transition and the onset of agriculture. In the terrestrial realm lakes offer a unique window on changes in human forcing of earth surface processes from a sedimentary flux perspective, because unlike alluvial and hill-slope systems sedimentation is broadly continuous and uninterrupted. Dearing and Jones (2003) showed for a global dataset of lakes a 5-10 fold increase in sediment delivery comparing pre- and post-anthropogenic disturbance. Here sediment records from several lakes in lowland agricultural landscapes are presented to examine the changes in the flux and composition of materials delivered from their catchments. By definition the lakes record the switch to a human dominated system, but not necessary in accelerated sediment accumulation rates with changes in sediment composition equally important. Data from Crose, Hatch and Peckforton Meres, in lowland northwest England are interrogated producing quantitative land-cover reconstructions from pollen spectra calculated using the REVEALS model (Sugita, 2007), geochemical evidence for changes sediment provenance and flux, and 14C and stable Pb pollutant based chronological models detecting changes in sediment accumulation rate. The lake sediment geochemistry points to several phases of heightened human impact within these small agricultural catchments. Following small-in-scale forest cover reductions and limited impacts in terms of sediment flux during the Neolithic, the Bronze to Iron Age saw the first substantial reductions in forest cover and widespread expansions of agriculture. In some cases the catchment responses, for example here detected via dry mass Zr concentrations, were substantial and outstrip later impacts driven by more intensive agriculture e.g. early Medieval, Norman Conquest and 19th century AD. These themes are developed in relation to the concept of an Anthropocene and wider European lake sediment record. References Brown AG, Tooth S, Chiverrell RC, Rose J, Thomas DSG, Wainwright J, Bullard JE, Thorndycraft VR, Aalto R, Downs P. 2013. The Anthropocene: is there a geomorphological case? Earth Surface Processes and Landforms 38: 431-434. Dearing JA, Jones RT. 2003. Coupling temporal and spatial dimensions of global sediment flux through lake and marine sediment records. Global and Planetary Change 39: 147-168. Sugita S. 2007. Theory of quantitative reconstruction of vegetation I: pollen from large sites REVEALS regional vegetation composition. Holocene 17, 2: 229-241.

Construction and updating of event models in auditory event processing.

PubMed

Huff, Markus; Maurer, Annika E; Brich, Irina; Pagenkopf, Anne; Wickelmaier, Florian; Papenmeier, Frank

2018-02-01

Humans segment the continuous stream of sensory information into distinct events at points of change. Between 2 events, humans perceive an event boundary. Present theories propose changes in the sensory information to trigger updating processes of the present event model. Increased encoding effort finally leads to a memory benefit at event boundaries. Evidence from reading time studies (increased reading times with increasing amount of change) suggest that updating of event models is incremental. We present results from 5 experiments that studied event processing (including memory formation processes and reading times) using an audio drama as well as a transcript thereof as stimulus material. Experiments 1a and 1b replicated the event boundary advantage effect for memory. In contrast to recent evidence from studies using visual stimulus material, Experiments 2a and 2b found no support for incremental updating with normally sighted and blind participants for recognition memory. In Experiment 3, we replicated Experiment 2a using a written transcript of the audio drama as stimulus material, allowing us to disentangle encoding and retrieval processes. Our results indicate incremental updating processes at encoding (as measured with reading times). At the same time, we again found recognition performance to be unaffected by the amount of change. We discuss these findings in light of current event cognition theories. (PsycINFO Database Record (c) 2018 APA, all rights reserved).

Auditory, Tactile, and Audiotactile Information Processing Following Visual Deprivation

ERIC Educational Resources Information Center

Occelli, Valeria; Spence, Charles; Zampini, Massimiliano

2013-01-01

We highlight the results of those studies that have investigated the plastic reorganization processes that occur within the human brain as a consequence of visual deprivation, as well as how these processes give rise to behaviorally observable changes in the perceptual processing of auditory and tactile information. We review the evidence showing…

Anger and the Change Process.

ERIC Educational Resources Information Center

Jacobson, Bonnie

Certain major thinkers regard both change and anger as inevitable aspects of human living. A system called Re-Creative Psychology (originally conceived by Paul Frisch) addresses one way to frame anger in order to create constructive change. It is an organized system of behavior management which deals with three broad categories:…

Singapore Students' Misconceptions of Climate Change

ERIC Educational Resources Information Center

Chang, Chew-Hung; Pascua, Liberty

2016-01-01

Climate change is an important theme in the investigation of human-environment interactions in geographic education. This study explored the nature of students' understanding of concepts and processes related to climate change. Through semi-structured interviews, data was collected from 27 Secondary 3 (Grade 9) students from Singapore. The data…

Environmental effects of ozone depletion and its interactions with climate change: Progress report, 2016

EPA Science Inventory

When considering the effects of climate change, it has become clear that processes resulting in changes in stratospheric ozone are more complex than previously believed. As a result of this, human health and environmental issues will be longer-lasting and more regionally variable...

Science-management collaborations: Developing adaptation options for National Forests

Treesearch

Forest Service U.S. Department of Agriculture

2010-01-01

Climate is constantly changing, prompting natural and managed ecosystems to adjust. As a natural process, adaptation refers to the reactive changes that species and ecosystems make in response to environmental changes. With human intervention, adaptation refers to management actions and decisions that help ecological, social, and economic systems accommodate challenges...

Reflections on the differences between religion and culture.

PubMed

Bonney, Richard

2004-01-01

Culture may be thought of as a causal agent that affects the evolutionary process by uniquely human means. Religion, on the other hand, is considered a process of revelation and contains the concept of the "faithful" who receive the message of revelation. Culture permits the "self-conscious evaluation of human possibilities" and therefore presents a device for increasing human control over species change. There are dangers, however, in accepting cultural relativism without any constraint, such as respect for human life and dignity. In this article, the author attempts to clarify the boundaries between religion and culture and acknowledges that further research is needed on the religion/culture dichotomy.

Gray Wave of the Great Transformation: A Satellite View of Urbanization, Climate Change, and Food Security

NASA Technical Reports Server (NTRS)

Imhoff, Marc Lee; Kamiell, Arnon Menahem

2010-01-01

Land cover change driven by human activity is profoundly affecting Earth's natural systems with impacts ranging from a loss of biological diversity to changes in regional and global climate. This change has been so pervasive and progressed so rapidly, compared to natural processes, scientists refer to it as "the great transformation". Urbanization or the 'gray wave' of land transformation is being increasingly recognized as an important process in global climate change. A hallmark of our success as a species, large urban conglomerates do in fact alter the land surface so profoundly that both local climate and the basic ecology of the landscape are affected in ways that have consequences to human health and economic well-being. Fortunately we have incredible new tools for planning and developing urban places that are both enjoyable and sustainable. A suite of Earth observing satellites is making it possible to study the interactions between urbanization, biological processes, and weather and climate. Using these Earth Observatories we are learning how urban heat islands form and potentially ameliorate them, how urbanization can affect rainfall, pollution, and surface water recharge at the local level and climate and food security globally.

Drought definitions and processes: how do humans fit in?

NASA Astrophysics Data System (ADS)

Van Loon, Anne; Van Lanen, Henny; Gleeson, Tom

2015-04-01

Drought is commonly defined as a temporary lack of water compared to normal conditions. In the traditional definition used in the natural sciences (climate science, hydrology, earth science) only natural drivers are included and the human effect on water resources is excluded. Drought impact studies, however, using observed crop yields, wildfire data, reservoir information, etc., can hardy make this division. The interdisciplinarity of drought asks for a broader definition that considers the interplay between the hazard, impacts and management. In flood research, human effects on the volume and timing of the flood event are traditionally taken into account and there is the awareness that human factors like channel modification, land surface changes and water supply engineering can both intensify and reduce flooding. Drought researchers can learn from the flooding community and try to elucidate the effects of human factors on drought duration and severity. This is not only a necessary step to answer relevant societal questions in the anthropocene, but also the IAHS Panta Rhei initiative urges hydrologists to include the connection with human systems. We propose a paradigm shift in the definition of drought, namely to expand it to include the effects of human action. Here, we will present a conceptual diagram that will do justice to the interdisciplinarity of drought. We will discuss the complex interconnected system of climate - hydrology - society - ecosystem and which processes in that system are most relevant to take into consideration when studying drought. The revised definition provides recognition and a common ground to researchers in all fields of research and is better aligned with drought impacts and with stakeholders' and policy maker's views on drought. We will also go into some of the pitfalls and challenges that come with applying this revised definition. For example, the natural and human-induced processes related to drought can have different scales and it is important that we consider both natural and human-induced variability instead of long-term change (such as climate change, desertification and depletion). This discussion of revised drought definitions and processes should inform drought quantification, so that the effects of human factors on drought can also be quantified. Just as for floods, the results of these analyses can then feed into the management of highly anthropogenic water systems.

Proceedings, 1995 meeting of the Northern Global Change Program; 1995 March 14-16; Pittsburgh, PA. : Introduction/Environmental Change

Treesearch

John Hom; Richard Birdsey; Kelly O' Brian; eds.

1996-01-01

Contains articles presented at the 1995 Northern Global Change Program meeting on the following topics: monitoring and predicting regional environmental change, responses of northern tree species to regional stress, responses of ecosystem processes to regional stress, forest and landscape responses to regional stress and management activities, human-forest interactions...

A rigorous approach to facilitate and guarantee the correctness of the genetic testing management in human genome information systems.

PubMed

Araújo, Luciano V; Malkowski, Simon; Braghetto, Kelly R; Passos-Bueno, Maria R; Zatz, Mayana; Pu, Calton; Ferreira, João E

2011-12-22

Recent medical and biological technology advances have stimulated the development of new testing systems that have been providing huge, varied amounts of molecular and clinical data. Growing data volumes pose significant challenges for information processing systems in research centers. Additionally, the routines of genomics laboratory are typically characterized by high parallelism in testing and constant procedure changes. This paper describes a formal approach to address this challenge through the implementation of a genetic testing management system applied to human genome laboratory. We introduced the Human Genome Research Center Information System (CEGH) in Brazil, a system that is able to support constant changes in human genome testing and can provide patients updated results based on the most recent and validated genetic knowledge. Our approach uses a common repository for process planning to ensure reusability, specification, instantiation, monitoring, and execution of processes, which are defined using a relational database and rigorous control flow specifications based on process algebra (ACP). The main difference between our approach and related works is that we were able to join two important aspects: 1) process scalability achieved through relational database implementation, and 2) correctness of processes using process algebra. Furthermore, the software allows end users to define genetic testing without requiring any knowledge about business process notation or process algebra. This paper presents the CEGH information system that is a Laboratory Information Management System (LIMS) based on a formal framework to support genetic testing management for Mendelian disorder studies. We have proved the feasibility and showed usability benefits of a rigorous approach that is able to specify, validate, and perform genetic testing using easy end user interfaces.

A rigorous approach to facilitate and guarantee the correctness of the genetic testing management in human genome information systems

PubMed Central

2011-01-01

Background Recent medical and biological technology advances have stimulated the development of new testing systems that have been providing huge, varied amounts of molecular and clinical data. Growing data volumes pose significant challenges for information processing systems in research centers. Additionally, the routines of genomics laboratory are typically characterized by high parallelism in testing and constant procedure changes. Results This paper describes a formal approach to address this challenge through the implementation of a genetic testing management system applied to human genome laboratory. We introduced the Human Genome Research Center Information System (CEGH) in Brazil, a system that is able to support constant changes in human genome testing and can provide patients updated results based on the most recent and validated genetic knowledge. Our approach uses a common repository for process planning to ensure reusability, specification, instantiation, monitoring, and execution of processes, which are defined using a relational database and rigorous control flow specifications based on process algebra (ACP). The main difference between our approach and related works is that we were able to join two important aspects: 1) process scalability achieved through relational database implementation, and 2) correctness of processes using process algebra. Furthermore, the software allows end users to define genetic testing without requiring any knowledge about business process notation or process algebra. Conclusions This paper presents the CEGH information system that is a Laboratory Information Management System (LIMS) based on a formal framework to support genetic testing management for Mendelian disorder studies. We have proved the feasibility and showed usability benefits of a rigorous approach that is able to specify, validate, and perform genetic testing using easy end user interfaces. PMID:22369688

Think Locally, Act Globally! Linking Local and Global Communities through Democracy and Environment. Hands-On! Developing Active Learning Modules on the Human Dimensions of Global Change.

ERIC Educational Resources Information Center

Dowler, Lorraine

Designed so that it can be adapted to a wide range of student abilities and institutional settings, this learning module on the human dimensions of global change seeks to: actively engage students in problem solving, challenge them to think critically, invite them to participate in the process of scientific inquiry, and involve them in cooperative…

Combining polarimetry and spectropolarimetry techniques in diagnostics of cancer changes in biological tissues

NASA Astrophysics Data System (ADS)

Yermolenko, Sergey; Ivashko, Pavlo; Gruia, Ion; Gruia, Maria; Peresunko, Olexander; Zelinska, Natalia; Voloshynskyi, Dmytro; Fedoruk, Olexander; Zimnyakov, Dmitry; Alonova, Marina

2015-02-01

The aim of the study is combining polarimetry and spectropolarimetry techniques for identifying the changes of opticalgeometrical structure in different kinds of biotissues with solid tumours. It is researched that a linear dichroism appears in biotissues (human esophagus, muscle tissue of rats, human prostate tissue, cervical smear) with cancer diseases, magnitude of which depends on the type of the tissue and on the time of cancer process development.

Contribution of Neuroimaging Studies to Understanding Development of Human Cognitive Brain Functions

PubMed Central

Morita, Tomoyo; Asada, Minoru; Naito, Eiichi

2016-01-01

Humans experience significant physical and mental changes from birth to adulthood, and a variety of perceptual, cognitive and motor functions mature over the course of approximately 20 years following birth. To deeply understand such developmental processes, merely studying behavioral changes is not sufficient; simultaneous investigation of the development of the brain may lead us to a more comprehensive understanding. Recent advances in noninvasive neuroimaging technologies largely contribute to this understanding. Here, it is very important to consider the development of the brain from the perspectives of “structure” and “function” because both structure and function of the human brain mature slowly. In this review, we first discuss the process of structural brain development, i.e., how the structure of the brain, which is crucial when discussing functional brain development, changes with age. Second, we introduce some representative studies and the latest studies related to the functional development of the brain, particularly for visual, facial recognition, and social cognition functions, all of which are important for humans. Finally, we summarize how brain science can contribute to developmental study and discuss the challenges that neuroimaging should address in the future. PMID:27695409

DOE Office of Scientific and Technical Information (OSTI.GOV)

Allen, Melissa R.; Aziz, H. M. Abdul; Coletti, Mark A.

Changing human activity within a geographical location may have significant influence on the global climate, but that activity must be parameterized in such a way as to allow these high-resolution sub-grid processes to affect global climate within that modeling framework. Additionally, we must have tools that provide decision support and inform local and regional policies regarding mitigation of and adaptation to climate change. The development of next-generation earth system models, that can produce actionable results with minimum uncertainties, depends on understanding global climate change and human activity interactions at policy implementation scales. Unfortunately, at best we currently have only limitedmore » schemes for relating high-resolution sectoral emissions to real-time weather, ultimately to become part of larger regions and well-mixed atmosphere. Moreover, even our understanding of meteorological processes at these scales is imperfect. This workshop addresses these shortcomings by providing a forum for discussion of what we know about these processes, what we can model, where we have gaps in these areas and how we can rise to the challenge to fill these gaps.« less

Emerging methods for the study of coastal ecosystem landscape structure and change

USGS Publications Warehouse

Brock, John C.; Danielson, Jeffrey J.; Purkis, Sam

2013-01-01

Coastal landscapes are heterogeneous, dynamic, and evolve over a range of time scales due to intertwined climatic, geologic, hydrologic, biologic, and meteorological processes, and are also heavily impacted by human development, commercial activities, and resource extraction. A diversity of complex coastal systems around the globe, spanning glaciated shorelines to tropical atolls, wetlands, and barrier islands are responding to multiple human and natural drivers. Interdisciplinary research based on remote-sensing observations linked to process studies and models is required to understand coastal ecosystem landscape structure and change. Moreover, new techniques for coastal mapping and monitoring are increasingly serving the needs of policy-makers and resource managers across local, regional, and national scales. Emerging remote-sensing methods associated with a diversity of instruments and platforms are a key enabling element of integrated coastal ecosystem studies. These investigations require both targeted and synoptic mapping, and involve the monitoring of formative processes such as hydrodynamics, sediment transport, erosion, accretion, flooding, habitat modification, land-cover change, and biogeochemical fluxes.

IMPLICATIONS OF GLOBAL CLIMATE CHANGE FOR THE ASSESSMENT AND MANAGEMENT OF HUMAN HEALTH RISKS OF CHEMICALS IN THE NATURAL ENVIRONMENT

PubMed Central

Balbus, John M; Boxall, Alistair BA; Fenske, Richard A; McKone, Thomas E; Zeise, Lauren

2013-01-01

Global climate change (GCC) is likely to alter the degree of human exposure to pollutants and the response of human populations to these exposures, meaning that risks of pollutants could change in the future. The present study, therefore, explores how GCC might affect the different steps in the pathway from a chemical source in the environment through to impacts on human health and evaluates the implications for existing risk-assessment and management practices. In certain parts of the world, GCC is predicted to increase the level of exposure of many environmental pollutants due to direct and indirect effects on the use patterns and transport and fate of chemicals. Changes in human behavior will also affect how humans come into contact with contaminated air, water, and food. Dietary changes, psychosocial stress, and coexposure to stressors such as high temperatures are likely to increase the vulnerability of humans to chemicals. These changes are likely to have significant implications for current practices for chemical assessment. Assumptions used in current exposure-assessment models may no longer apply, and existing monitoring methods may not be robust enough to detect adverse episodic changes in exposures. Organizations responsible for the assessment and management of health risks of chemicals therefore need to be more proactive and consider the implications of GCC for their procedures and processes. Environ. Toxicol. Chem. 2013;32:62–78. © 2012 SETAC PMID:23147420

Language Is a Complex Adaptive System: Position Paper

ERIC Educational Resources Information Center

Beckner, Clay; Blythe, Richard; Bybee, Joan; Christiansen, Morten H.; Croft, William; Ellis, Nick C.; Holland, John; Ke, Jinyun; Larsen-Freeman, Diane; Schoenemann, Tom

2009-01-01

Language has a fundamentally social function. Processes of human interaction along with domain-general cognitive processes shape the structure and knowledge of language. Recent research in the cognitive sciences has demonstrated that patterns of use strongly affect how language is acquired, is used, and changes. These processes are not independent…

The human physiological impact of global deoxygenation.

PubMed

Martin, Daniel; McKenna, Helen; Livina, Valerie

2017-01-01

There has been a clear decline in the volume of oxygen in Earth's atmosphere over the past 20 years. Although the magnitude of this decrease appears small compared to the amount of oxygen in the atmosphere, it is difficult to predict how this process may evolve, due to the brevity of the collected records. A recently proposed model predicts a non-linear decay, which would result in an increasingly rapid fall-off in atmospheric oxygen concentration, with potentially devastating consequences for human health. We discuss the impact that global deoxygenation, over hundreds of generations, might have on human physiology. Exploring the changes between different native high-altitude populations provides a paradigm of how humans might tolerate worsening hypoxia over time. Using this model of atmospheric change, we predict that humans may continue to survive in an unprotected atmosphere for ~3600 years. Accordingly, without dramatic changes to the way in which we interact with our planet, humans may lose their dominance on Earth during the next few millennia.

Forest fragmentation and selective logging have inconsistent effects on multiple animal-mediated ecosystem processes in a tropical forest.

PubMed

Schleuning, Matthias; Farwig, Nina; Peters, Marcell K; Bergsdorf, Thomas; Bleher, Bärbel; Brandl, Roland; Dalitz, Helmut; Fischer, Georg; Freund, Wolfram; Gikungu, Mary W; Hagen, Melanie; Garcia, Francisco Hita; Kagezi, Godfrey H; Kaib, Manfred; Kraemer, Manfred; Lung, Tobias; Naumann, Clas M; Schaab, Gertrud; Templin, Mathias; Uster, Dana; Wägele, J Wolfgang; Böhning-Gaese, Katrin

2011-01-01

Forest fragmentation and selective logging are two main drivers of global environmental change and modify biodiversity and environmental conditions in many tropical forests. The consequences of these changes for the functioning of tropical forest ecosystems have rarely been explored in a comprehensive approach. In a Kenyan rainforest, we studied six animal-mediated ecosystem processes and recorded species richness and community composition of all animal taxa involved in these processes. We used linear models and a formal meta-analysis to test whether forest fragmentation and selective logging affected ecosystem processes and biodiversity and used structural equation models to disentangle direct from biodiversity-related indirect effects of human disturbance on multiple ecosystem processes. Fragmentation increased decomposition and reduced antbird predation, while selective logging consistently increased pollination, seed dispersal and army-ant raiding. Fragmentation modified species richness or community composition of five taxa, whereas selective logging did not affect any component of biodiversity. Changes in the abundance of functionally important species were related to lower predation by antbirds and higher decomposition rates in small forest fragments. The positive effects of selective logging on bee pollination, bird seed dispersal and army-ant raiding were direct, i.e. not related to changes in biodiversity, and were probably due to behavioural changes of these highly mobile animal taxa. We conclude that animal-mediated ecosystem processes respond in distinct ways to different types of human disturbance in Kakamega Forest. Our findings suggest that forest fragmentation affects ecosystem processes indirectly by changes in biodiversity, whereas selective logging influences processes directly by modifying local environmental conditions and resource distributions. The positive to neutral effects of selective logging on ecosystem processes show that the functionality of tropical forests can be maintained in moderately disturbed forest fragments. Conservation concepts for tropical forests should thus include not only remaining pristine forests but also functionally viable forest remnants.

Forest Fragmentation and Selective Logging Have Inconsistent Effects on Multiple Animal-Mediated Ecosystem Processes in a Tropical Forest

PubMed Central

Schleuning, Matthias; Farwig, Nina; Peters, Marcell K.; Bergsdorf, Thomas; Bleher, Bärbel; Brandl, Roland; Dalitz, Helmut; Fischer, Georg; Freund, Wolfram; Gikungu, Mary W.; Hagen, Melanie; Garcia, Francisco Hita; Kagezi, Godfrey H.; Kaib, Manfred; Kraemer, Manfred; Lung, Tobias; Schaab, Gertrud; Templin, Mathias; Uster, Dana; Wägele, J. Wolfgang; Böhning-Gaese, Katrin

2011-01-01

Forest fragmentation and selective logging are two main drivers of global environmental change and modify biodiversity and environmental conditions in many tropical forests. The consequences of these changes for the functioning of tropical forest ecosystems have rarely been explored in a comprehensive approach. In a Kenyan rainforest, we studied six animal-mediated ecosystem processes and recorded species richness and community composition of all animal taxa involved in these processes. We used linear models and a formal meta-analysis to test whether forest fragmentation and selective logging affected ecosystem processes and biodiversity and used structural equation models to disentangle direct from biodiversity-related indirect effects of human disturbance on multiple ecosystem processes. Fragmentation increased decomposition and reduced antbird predation, while selective logging consistently increased pollination, seed dispersal and army-ant raiding. Fragmentation modified species richness or community composition of five taxa, whereas selective logging did not affect any component of biodiversity. Changes in the abundance of functionally important species were related to lower predation by antbirds and higher decomposition rates in small forest fragments. The positive effects of selective logging on bee pollination, bird seed dispersal and army-ant raiding were direct, i.e. not related to changes in biodiversity, and were probably due to behavioural changes of these highly mobile animal taxa. We conclude that animal-mediated ecosystem processes respond in distinct ways to different types of human disturbance in Kakamega Forest. Our findings suggest that forest fragmentation affects ecosystem processes indirectly by changes in biodiversity, whereas selective logging influences processes directly by modifying local environmental conditions and resource distributions. The positive to neutral effects of selective logging on ecosystem processes show that the functionality of tropical forests can be maintained in moderately disturbed forest fragments. Conservation concepts for tropical forests should thus include not only remaining pristine forests but also functionally viable forest remnants. PMID:22114695

Technology Changes Intelligence: Societal Implications and Soaring IQs.

ERIC Educational Resources Information Center

Sternberg, Robert J.

1997-01-01

Discusses the effects technology may have on human intelligence. Topics include the use of computational devices, including calculators, in schools; the changes word processing has brought about in writing; the use of television; and the effects of weapons on children. (LRW)

Dynamics of scene representations in the human brain revealed by magnetoencephalography and deep neural networks

PubMed Central

Cichy, Radoslaw Martin; Khosla, Aditya; Pantazis, Dimitrios; Oliva, Aude

2017-01-01

Human scene recognition is a rapid multistep process evolving over time from single scene image to spatial layout processing. We used multivariate pattern analyses on magnetoencephalography (MEG) data to unravel the time course of this cortical process. Following an early signal for lower-level visual analysis of single scenes at ~100 ms, we found a marker of real-world scene size, i.e. spatial layout processing, at ~250 ms indexing neural representations robust to changes in unrelated scene properties and viewing conditions. For a quantitative model of how scene size representations may arise in the brain, we compared MEG data to a deep neural network model trained on scene classification. Representations of scene size emerged intrinsically in the model, and resolved emerging neural scene size representation. Together our data provide a first description of an electrophysiological signal for layout processing in humans, and suggest that deep neural networks are a promising framework to investigate how spatial layout representations emerge in the human brain. PMID:27039703

Learning and Organizational Change in SPI Initiatives

NASA Astrophysics Data System (ADS)

Heikkilä, Marikka

Explaining how organizations chance has been a central and enduring quest of management scholars and many other disciplines. In order to be successful change requires not only a new process or technology but also the engagement and participation of the people involved. In this vein the change process results in new behavior and is routinized in practical daily business life of the company. Change management provides a framework for managing the human side of these changes. In this article we present a literature review on the change management in the context of Software Process Improvement. The traditional view of learning, as a “lessons learned” or post-mortem reporting activity is often apparent in SPI literature. However, learning can also be viewed as a continuous change process where specific learning cycle starts with creative conflict and ends up in formal norms and systems. Since this perspective has almost no visibility in SPI literature of past it could show a new direction to the future development of change management in SPI.

Geography and glocal scale - generational conversion/Geografia i skala glokalna - przemiana generacyjna

NASA Astrophysics Data System (ADS)

Pirveli, Marika; Lewczuk, Barbara

2013-12-01

The proposed text presents a conceptual change in the scope of some of the key concepts in the light of the two dictionaries (Britannica and Human Geography Dictionary) and Anglo-Saxon publications about the future of geography. Then, it combines the concept of references to the ongoing interdisciplinary studies included in the structure of the University of the Second and Third Generation. Applications built this way are of two types: (1) referring to a fundamental change in the process within the human perception of the environment for generations X and Y, and (2) referring to the process of glocalization, glocal scale and premises of the University of the Third Generation (3GU)

The 2nd State of the Carbon Cycle Report (SOCCR-2): Process, Progress and Institutional Context

NASA Astrophysics Data System (ADS)

Shrestha, G.; Cavallaro, N.; Zhu, Z.; Larson, E. K.; Butler, J. H.

2017-12-01

Over 200 scientists and program managers from U.S., Mexican and Canadian government and non-government institutions have been collaborating on SOCCR-2 since 2015. Responding to the U.S. Global Change Research Act (1990) and the U.S. Carbon Cycle Science Plan (2011), this special Sustained National Climate Assessment report covers many of the GCRA mandated sectors such as agriculture, energy, forestry, aquatic systems, coasts, wetlands, atmospheric and human social systems, integrating the scientific uncertainties and analyzing the effects of global change on the carbon cycle and vice versa, including projections for both human- induced and natural changes. This presentation covers the SOCCR-2 process, progress and institutional context, providing a historical perspective on the interagency instruments and mechanisms that have facilitated the last decades of carbon cycle science reflected in SOCCR-2.

Freezing and thawing effects on fat, protein, and lactose levels of human natural milk administered by gavage and continuous infusion.

PubMed

Abranches, Andrea D; Soares, Fernanda V M; Junior, Saint-Clair G; Moreira, Maria Elisabeth L

2014-01-01

to analyze the changes in human milk macronutrients: fat, protein, and lactose in natural human milk (raw), frozen and thawed, after administration simulation by gavage and continuous infusion. an experimental study was performed with 34 human milk samples. The infrared spectrophotometry using the infrared analysis equipment MilkoScan Minor® (Foss, Denmark) equipment was used to analyze the macronutrients in human milk during the study phases. The analyses were performed in natural (raw) samples and after freezing and fast thawing following two steps: gavage and continuous infusion. The non-parametric Wilcoxon test for paired samples was used for the statistical analysis. the fat content was significantly reduced after administration by continuous infusion (p<0.001) during administration of both raw and thawed samples. No changes in protein and lactose content were observed between the two forms of infusion. However, the thawing process significantly increased the levels of lactose and milk protein. the route of administration by continuous infusion showed the greatest influence on fat loss among all the processes required for human milk administration. Copyright © 2014 Sociedade Brasileira de Pediatria. Published by Elsevier Editora Ltda. All rights reserved.

Evaluating landscape health: Integrating societal goals and biophysical process

USGS Publications Warehouse

Rapport, D.J.; Gaudet, C.; Karr, J.R.; Baron, Jill S.; Bohlen, C.; Jackson, W.; Jones, Bruce; Naiman, R.J.; Norton, B.; Pollock, M. M.

1998-01-01

Evaluating landscape change requires the integration of the social and natural sciences. The social sciences contribute to articulating societal values that govern landscape change, while the natural sciences contribute to understanding the biophysical processes that are influenced by human activity and result in ecological change. Building upon Aldo Leopold's criteria for landscape health, the roles of societal values and biophysical processes in shaping the landscape are explored. A framework is developed for indicators of landscape health and integrity. Indicators of integrity are useful in measuring biological condition relative to the condition in landscapes largely unaffected by human activity, while indicators of health are useful in evaluating changes in highly modified landscapes. Integrating societal goals and biophysical processes requires identification of ecological services to be sustained within a given landscape. It also requires the proper choice of temporal and spatial scales. Societal values are based upon inter-generational concerns at regional scales (e.g. soil and ground water quality). Assessing the health and integrity of the environment at the landscape scale over a period of decades best integrates societal values with underlying biophysical processes. These principles are illustrated in two contrasting case studies: (1) the South Platte River study demonstrates the role of complex biophysical processes acting at a distance; and (2) the Kissimmee River study illustrates the critical importance of social, cultural and economic concerns in the design of remedial action plans. In both studies, however, interactions between the social and the biophysical governed the landscape outcomes. The legacy of evolution and the legacy of culture requires integration for the purpose of effectively coping with environmental change.

Summary and synthesis

Treesearch

V. Alaric Sample; Christopher Topik

2014-01-01

America’s forests are undergoing changes unlike any seen before in human history. The concept of the Anthropocene Era, a new geologic epoch characterized by anthropogenic dominance over the Earth’s systems, has become an important framework for thinking about the processes and consequences of worldwide environmental change, particularly global climate change,...

Adapting to and Coping with the Threat and Impacts of Climate Change

ERIC Educational Resources Information Center

Reser, Joseph P.; Swim, Janet K.

2011-01-01

This article addresses the nature and challenge of adaptation in the context of global climate change. The complexity of "climate change" as threat, environmental stressor, risk domain, and impacting process with dramatic environmental and human consequences requires a synthesis of perspectives and models from diverse areas of psychology to…

HRD & Business Outcomes.

ERIC Educational Resources Information Center

1996

These four papers were presented at a symposium on human resource development (HRD) and business outcomes moderated by Barbara L. Swanson at the 1996 conference of the Academy of Human Resource Development. "Incorporating Continuous Learning into a Cultural Change Process" (Carol Ann Zulauf, Joseph A. Ilacqua), focuses on best practices at…

Environmental and Landscape Remote Sensing Using Free and Open Source Image Processing Tools

EPA Science Inventory

As global climate change and human activities impact the environment, there is a growing need for scientific tools to monitor and measure environmental conditions that support human and ecological health. Remotely sensed imagery from satellite and airborne platforms provides a g...

Changing Homeland Security: Shape, Patterns, Not Programs

DTIC Science & Technology

2006-10-01

Nietzsche wrote about this process: To make plans and project designs brings with it many good sensations; and whoever had the strength to be...Friedrich Wilhelm Nietzsche , Human, All Too Human (Stanford University Press, 2000). 3 The phrase “homeland security community” and the pronoun “we

Women in Combat: The Case for Combat Exclusion

DTIC Science & Technology

1993-03-03

first we need to note the dual role of the hormones in gender differences. These processes are common not only to humans, but to all mammals. Sex...theories of how this difference helped both men and women in the performance of their gender roles through human history. Men needed persistence to...these bold and sweeping social changes, gender roles did not, in the long run, change. Within one generation 134 the kibbutz came to reflect the

[Epigenetic heredity (deoxyribonucleic acid methylation): Clinical context in neurodegenerative disorders and ATXN2 gene].

PubMed

Laffita-Mesa, José Miguel; Bauer, Peter

2014-10-21

Epigenetics is the group of changes in the phenotype which are related with the process independently of the primary DNA sequence. These changes are intimately related with changes in the gene expression level and its profile across the body. These are mediated by histone tail modifications, DNA methylation, micro-RNAs, with chromatin remodeling remaining as the foundation of epigenetic changes. DNA methylation involves the covalent addition of methyl group to cytosine of the DNA, which is mediated by methyltransferases enzymes. DNA methylation regulates gene expression by repressing transcription, while de-methylation activates gene transcription. Several human diseases are related with the epigenetic process: cancer, Alzheimer disease, stroke, Parkinson disease, and diabetes. We present here the basis of epigenetic inheritance and show the pathogenic mechanisms relating epigenetics in human diseases, specifically with regard to neurodegeneration. We discuss current concepts aimed at understanding the contribution of epigenetics to human neurodegenerative diseases. We also discuss recent findings obtained in our and other centers regarding the ATXN2 gene that causes spinocerebellar ataxia 2 and amyotrophic lateral sclerosis. Epigenetics play a pivotal role in the pathogenesis of human diseases and in several neurodegenerative disorders, and this knowledge will illuminate the pathways in the diagnostic and therapeutic field, which ultimately will be translated into the clinic context of neurodegenerative diseases. Copyright © 2013 Elsevier España, S.L.U. All rights reserved.

Developmental Processes across the First Two Years of Parenthood: Stability and Change in Adult Attachment Style

ERIC Educational Resources Information Center

Stern, Jessica A.; Fraley, R. Chris; Jones, Jason D.; Gross, Jacquelyn T.; Shaver, Phillip R.; Cassidy, Jude

2018-01-01

The first months after becoming a new parent are a unique and important period in human development. Despite substantial research on the many social and biological changes that occur during the first months of parenthood, little is known about changes in mothers' attachment. The present study examines developmental stability and change in…

Perceptual Learning Styles Modalities Utilizing the Multimodal Paired Associates Learning Test: An Analysis of Latinos Born in Central and South America

ERIC Educational Resources Information Center

Ramirez, Matias

2017-01-01

Businesses and Human Resources professionals face the ongoing challenge of continuously upskilling and developing employees. Changes to processes or procedures, changes in technology, changes in job functions, and updates or changes to compliance laws or regulations are all reasons that employees must attend and complete employer-developed…

Speech Communication Behavior; Perspectives and Principles.

ERIC Educational Resources Information Center

Barker, Larry L., Ed.; Kibler, Robert J., Ed.

Readings are included on seven topics: 1) theories and models of communication processes, 2) acquisition and performance of communication behaviors, 3) human information processing and diffusion, 4) persuasion and attitude change, 5) psychophysiological approaches to studying communication, 6) interpersonal communication within transracial…

Using avian functional traits to assess the impact of land-cover change on ecosystem processes linked to resilience in tropical forests.

PubMed

Bregman, Tom P; Lees, Alexander C; MacGregor, Hannah E A; Darski, Bianca; de Moura, Nárgila G; Aleixo, Alexandre; Barlow, Jos; Tobias, Joseph A

2016-12-14

Vertebrates perform key roles in ecosystem processes via trophic interactions with plants and insects, but the response of these interactions to environmental change is difficult to quantify in complex systems, such as tropical forests. Here, we use the functional trait structure of Amazonian forest bird assemblages to explore the impacts of land-cover change on two ecosystem processes: seed dispersal and insect predation. We show that trait structure in assemblages of frugivorous and insectivorous birds remained stable after primary forests were subjected to logging and fire events, but that further intensification of human land use substantially reduced the functional diversity and dispersion of traits, and resulted in communities that occupied a different region of trait space. These effects were only partially reversed in regenerating secondary forests. Our findings suggest that local extinctions caused by the loss and degradation of tropical forest are non-random with respect to functional traits, thus disrupting the network of trophic interactions regulating seed dispersal by forest birds and herbivory by insects, with important implications for the structure and resilience of human-modified tropical forests. Furthermore, our results illustrate how quantitative functional traits for specific guilds can provide a range of metrics for estimating the contribution of biodiversity to ecosystem processes, and the response of such processes to land-cover change. © 2016 The Author(s).

Using avian functional traits to assess the impact of land-cover change on ecosystem processes linked to resilience in tropical forests

PubMed Central

Bregman, Tom P.; Lees, Alexander C.; MacGregor, Hannah E. A.; Darski, Bianca; de Moura, Nárgila G.; Aleixo, Alexandre; Barlow, Jos

2016-01-01

Vertebrates perform key roles in ecosystem processes via trophic interactions with plants and insects, but the response of these interactions to environmental change is difficult to quantify in complex systems, such as tropical forests. Here, we use the functional trait structure of Amazonian forest bird assemblages to explore the impacts of land-cover change on two ecosystem processes: seed dispersal and insect predation. We show that trait structure in assemblages of frugivorous and insectivorous birds remained stable after primary forests were subjected to logging and fire events, but that further intensification of human land use substantially reduced the functional diversity and dispersion of traits, and resulted in communities that occupied a different region of trait space. These effects were only partially reversed in regenerating secondary forests. Our findings suggest that local extinctions caused by the loss and degradation of tropical forest are non-random with respect to functional traits, thus disrupting the network of trophic interactions regulating seed dispersal by forest birds and herbivory by insects, with important implications for the structure and resilience of human-modified tropical forests. Furthermore, our results illustrate how quantitative functional traits for specific guilds can provide a range of metrics for estimating the contribution of biodiversity to ecosystem processes, and the response of such processes to land-cover change. PMID:27928045

Transmission fidelity is the key to the build-up of cumulative culture

PubMed Central

Lewis, Hannah M.; Laland, Kevin N.

2012-01-01

Many animals have socially transmitted behavioural traditions, but human culture appears unique in that it is cumulative, i.e. human cultural traits increase in diversity and complexity over time. It is often suggested that high-fidelity cultural transmission is necessary for cumulative culture to occur through refinement, a process known as ‘ratcheting’, but this hypothesis has never been formally evaluated. We discuss processes of information transmission and loss of traits from a cognitive viewpoint alongside other cultural processes of novel invention (generation of entirely new traits), modification (refinement of existing traits) and combination (bringing together two established traits to generate a new trait). We develop a simple cultural transmission model that does not assume major evolutionary changes (e.g. in brain architecture) and show that small changes in the fidelity with which information is passed between individuals can lead to cumulative culture. In comparison, modification and combination have a lesser influence on, and novel invention appears unimportant to, the ratcheting process. Our findings support the idea that high-fidelity transmission is the key driver of human cumulative culture, and that progress in cumulative culture depends more on trait combination than novel invention or trait modification. PMID:22734060

Transmission fidelity is the key to the build-up of cumulative culture.

PubMed

Lewis, Hannah M; Laland, Kevin N

2012-08-05

Many animals have socially transmitted behavioural traditions, but human culture appears unique in that it is cumulative, i.e. human cultural traits increase in diversity and complexity over time. It is often suggested that high-fidelity cultural transmission is necessary for cumulative culture to occur through refinement, a process known as 'ratcheting', but this hypothesis has never been formally evaluated. We discuss processes of information transmission and loss of traits from a cognitive viewpoint alongside other cultural processes of novel invention (generation of entirely new traits), modification (refinement of existing traits) and combination (bringing together two established traits to generate a new trait). We develop a simple cultural transmission model that does not assume major evolutionary changes (e.g. in brain architecture) and show that small changes in the fidelity with which information is passed between individuals can lead to cumulative culture. In comparison, modification and combination have a lesser influence on, and novel invention appears unimportant to, the ratcheting process. Our findings support the idea that high-fidelity transmission is the key driver of human cumulative culture, and that progress in cumulative culture depends more on trait combination than novel invention or trait modification.

Gray Wave of the Great Transformation: A Satellite View of Urbanization, Climate, and Food Security

NASA Technical Reports Server (NTRS)

Imhoff, Marc L.

2007-01-01

Land cover change driven by human activity is profoundly affecting Earth's natural systems with impacts ranging from a loss of biological productivity to changes in atmospheric chemistry and regional and global climate. This change has been so pervasive and progressed so rapidly, compared to natural processes, scientists refer to it as 'the great transformation'. Urbanization or the 'gray wave' of this transformation is being increasingly recognized as an important process in global climate change. A hallmark of our success as a species, large urban conglomerates do in fact alter their environments so profoundly that the local climate, atmospheric composition, and the basic ecology of the landscape are affected in ways that have consequences to human health and economic well-being. Fortunately we have incredible new tools to observe and understand these processes in ways that can be used to plan and develop enjoyable and sustainable urban places. A suite of Earth observing satellites is making it possible to study the interactions between urbanization, biological processes, and the atmosphere including weather and climate. Using these Earth Observatories we are learning how urban heat islands form and potentially ameliorate them, how urbanization can affect rainfall, pollution, surface water recharge at the local level, and climate and food security globally.

Process Mining for Individualized Behavior Modeling Using Wireless Tracking in Nursing Homes

PubMed Central

Fernández-Llatas, Carlos; Benedi, José-Miguel; García-Gómez, Juan M.; Traver, Vicente

2013-01-01

The analysis of human behavior patterns is increasingly used for several research fields. The individualized modeling of behavior using classical techniques requires too much time and resources to be effective. A possible solution would be the use of pattern recognition techniques to automatically infer models to allow experts to understand individual behavior. However, traditional pattern recognition algorithms infer models that are not readily understood by human experts. This limits the capacity to benefit from the inferred models. Process mining technologies can infer models as workflows, specifically designed to be understood by experts, enabling them to detect specific behavior patterns in users. In this paper, the eMotiva process mining algorithms are presented. These algorithms filter, infer and visualize workflows. The workflows are inferred from the samples produced by an indoor location system that stores the location of a resident in a nursing home. The visualization tool is able to compare and highlight behavior patterns in order to facilitate expert understanding of human behavior. This tool was tested with nine real users that were monitored for a 25-week period. The results achieved suggest that the behavior of users is continuously evolving and changing and that this change can be measured, allowing for behavioral change detection. PMID:24225907

Changes in the hemagglutinin of H5N1 viruses during human infection – Influence on receptor binding☆

PubMed Central

Crusat, Martin; Liu, Junfeng; Palma, Angelina S.; Childs, Robert A.; Liu, Yan; Wharton, Stephen A.; Lin, Yi Pu; Coombs, Peter J.; Martin, Stephen R.; Matrosovich, Mikhail; Chen, Zi; Stevens, David J.; Hien, Vo Minh; Thanh, Tran Tan; Nhu, Le Nguyen Truc; Nguyet, Lam Anh; Ha, Do Quang; van Doorn, H.Rogier; Hien, Tran Tinh; Conradt, Harald S.; Kiso, Makoto; Gamblin, Steve J.; Chai, Wengang; Skehel, John J.; Hay, Alan J.; Farrar, Jeremy; de Jong, Menno D.; Feizi, Ten

2013-01-01

As avian influenza A(H5N1) viruses continue to circulate in Asia and Africa, global concerns of an imminent pandemic persist. Recent experimental studies suggest that efficient transmission between humans of current H5N1 viruses only requires a few genetic changes. An essential step is alteration of the virus hemagglutinin from preferential binding to avian receptors for the recognition of human receptors present in the upper airway. We have identified receptor-binding changes which emerged during H5N1 infection of humans, due to single amino acid substitutions, Ala134Val and Ile151Phe, in the hemagglutinin. Detailed biological, receptor-binding, and structural analyses revealed reduced binding of the mutated viruses to avian-like receptors, but without commensurate increased binding to the human-like receptors investigated, possibly reflecting a receptor-binding phenotype intermediate in adaptation to more human-like characteristics. These observations emphasize that evolution in nature of avian H5N1 viruses to efficient binding of human receptors is a complex multistep process. PMID:24050651

Real-time acquisition and display of flow contrast using speckle variance optical coherence tomography in a graphics processing unit.

PubMed

Xu, Jing; Wong, Kevin; Jian, Yifan; Sarunic, Marinko V

2014-02-01

In this report, we describe a graphics processing unit (GPU)-accelerated processing platform for real-time acquisition and display of flow contrast images with Fourier domain optical coherence tomography (FDOCT) in mouse and human eyes in vivo. Motion contrast from blood flow is processed using the speckle variance OCT (svOCT) technique, which relies on the acquisition of multiple B-scan frames at the same location and tracking the change of the speckle pattern. Real-time mouse and human retinal imaging using two different custom-built OCT systems with processing and display performed on GPU are presented with an in-depth analysis of performance metrics. The display output included structural OCT data, en face projections of the intensity data, and the svOCT en face projections of retinal microvasculature; these results compare projections with and without speckle variance in the different retinal layers to reveal significant contrast improvements. As a demonstration, videos of real-time svOCT for in vivo human and mouse retinal imaging are included in our results. The capability of performing real-time svOCT imaging of the retinal vasculature may be a useful tool in a clinical environment for monitoring disease-related pathological changes in the microcirculation such as diabetic retinopathy.

Coordinated Gene Expression of Neuroinflammatory and Cell Signaling Markers in Dorsolateral Prefrontal Cortex during Human Brain Development and Aging

PubMed Central

Primiani, Christopher T.; Ryan, Veronica H.; Rao, Jagadeesh S.; Cam, Margaret C.; Ahn, Kwangmi; Modi, Hiren R.; Rapoport, Stanley I.

2014-01-01

Background Age changes in expression of inflammatory, synaptic, and neurotrophic genes are not well characterized during human brain development and senescence. Knowing these changes may elucidate structural, metabolic, and functional brain processes over the lifespan, as well vulnerability to neurodevelopmental or neurodegenerative diseases. Hypothesis Expression levels of inflammatory, synaptic, and neurotrophic genes in the human brain are coordinated over the lifespan and underlie changes in phenotypic networks or cascades. Methods We used a large-scale microarray dataset from human prefrontal cortex, BrainCloud, to quantify age changes over the lifespan, divided into Development (0 to 21 years, 87 brains) and Aging (22 to 78 years, 144 brains) intervals, in transcription levels of 39 genes. Results Gene expression levels followed different trajectories over the lifespan. Many changes were intercorrelated within three similar groups or clusters of genes during both Development and Aging, despite different roles of the gene products in the two intervals. During Development, changes were related to reported neuronal loss, dendritic growth and pruning, and microglial events; TLR4, IL1R1, NFKB1, MOBP, PLA2G4A, and PTGS2 expression increased in the first years of life, while expression of synaptic genes GAP43 and DBN1 decreased, before reaching plateaus. During Aging, expression was upregulated for potentially pro-inflammatory genes such as NFKB1, TRAF6, TLR4, IL1R1, TSPO, and GFAP, but downregulated for neurotrophic and synaptic integrity genes such as BDNF, NGF, PDGFA, SYN, and DBN1. Conclusions Coordinated changes in gene transcription cascades underlie changes in synaptic, neurotrophic, and inflammatory phenotypic networks during brain Development and Aging. Early postnatal expression changes relate to neuronal, glial, and myelin growth and synaptic pruning events, while late Aging is associated with pro-inflammatory and synaptic loss changes. Thus, comparable transcriptional regulatory networks that operate throughout the lifespan underlie different phenotypic processes during Aging compared to Development. PMID:25329999

Coordinated gene expression of neuroinflammatory and cell signaling markers in dorsolateral prefrontal cortex during human brain development and aging.

PubMed

Primiani, Christopher T; Ryan, Veronica H; Rao, Jagadeesh S; Cam, Margaret C; Ahn, Kwangmi; Modi, Hiren R; Rapoport, Stanley I

2014-01-01

Age changes in expression of inflammatory, synaptic, and neurotrophic genes are not well characterized during human brain development and senescence. Knowing these changes may elucidate structural, metabolic, and functional brain processes over the lifespan, as well vulnerability to neurodevelopmental or neurodegenerative diseases. Expression levels of inflammatory, synaptic, and neurotrophic genes in the human brain are coordinated over the lifespan and underlie changes in phenotypic networks or cascades. We used a large-scale microarray dataset from human prefrontal cortex, BrainCloud, to quantify age changes over the lifespan, divided into Development (0 to 21 years, 87 brains) and Aging (22 to 78 years, 144 brains) intervals, in transcription levels of 39 genes. Gene expression levels followed different trajectories over the lifespan. Many changes were intercorrelated within three similar groups or clusters of genes during both Development and Aging, despite different roles of the gene products in the two intervals. During Development, changes were related to reported neuronal loss, dendritic growth and pruning, and microglial events; TLR4, IL1R1, NFKB1, MOBP, PLA2G4A, and PTGS2 expression increased in the first years of life, while expression of synaptic genes GAP43 and DBN1 decreased, before reaching plateaus. During Aging, expression was upregulated for potentially pro-inflammatory genes such as NFKB1, TRAF6, TLR4, IL1R1, TSPO, and GFAP, but downregulated for neurotrophic and synaptic integrity genes such as BDNF, NGF, PDGFA, SYN, and DBN1. Coordinated changes in gene transcription cascades underlie changes in synaptic, neurotrophic, and inflammatory phenotypic networks during brain Development and Aging. Early postnatal expression changes relate to neuronal, glial, and myelin growth and synaptic pruning events, while late Aging is associated with pro-inflammatory and synaptic loss changes. Thus, comparable transcriptional regulatory networks that operate throughout the lifespan underlie different phenotypic processes during Aging compared to Development.

Climate change and skin.

PubMed

Balato, N; Ayala, F; Megna, M; Balato, A; Patruno, C

2013-02-01

Global climate appears to be changing at an unprecedented rate. Climate change can be caused by several factors that include variations in solar radiation received by earth, oceanic processes (such as oceanic circulation), plate tectonics, and volcanic eruptions, as well as human-induced alterations of the natural world. Many human activities, such as the use of fossil fuel and the consequent accumulation of greenhouse gases in the atmosphere, land consumption, deforestation, industrial processes, as well as some agriculture practices are contributing to global climate change. Indeed, many authors have reported on the current trend towards global warming (average surface temperature has augmented by 0.6 °C over the past 100 years), decreased precipitation, atmospheric humidity changes, and global rise in extreme climatic events. The magnitude and cause of these changes and their impact on human activity have become important matters of debate worldwide, representing climate change as one of the greatest challenges of the modern age. Although many articles have been written based on observations and various predictive models of how climate change could affect social, economic and health systems, only few studies exist about the effects of this change on skin physiology and diseases. However, the skin is the most exposed organ to environment; therefore, cutaneous diseases are inclined to have a high sensitivity to climate. For example, global warming, deforestation and changes in precipitation have been linked to variations in the geographical distribution of vectors of some infectious diseases (leishmaniasis, lyme disease, etc) by changing their spread, whereas warm and humid environment can also encourage the colonization of the skin by bacteria and fungi. The present review focuses on the wide and complex relationship between climate change and dermatology, showing the numerous factors that are contributing to modify the incidence and the clinical pattern of many dermatoses.

Human Evolution: The Real Cause for Birth Palsy

PubMed Central

Sreekanth, R; Thomas, BP

2015-01-01

ABSTRACT Objective: Birth palsy, otherwise known as obstetric brachial plexus paralysis (OBPP), is a closed stretch injury to the brachial plexus of nerves during the birth process resulting in varying degree of paralysis and contractures of the upper limb. The study aimed to find out the susceptibility of humans and small-bodied primates to birth palsy. Method: A comparative study on parturition in modern humans, hominoids, hominids, small-bodied primates and great apes was done to determine if changes in the female pelvis and neonatal head and shoulder during human evolution is the real cause for OBPP. Results: During evolution, the morphology of the female pelvis and birth canal changed into a narrow and twisted one and also the size of the fetal head increased. Thus, the narrow and twisted pelvis of the mother, and the relatively large head and broad shoulders of the newborn has made the birthing process of modern human and small bodied primates a precarious fine-tuned act with a very narrow margin for error. This has necessitated proper obstetric care to reduce or even at times obviate the incidence of birth injuries like OBPP. Conclusion: Human evolution has made human babies susceptible to birth palsy and thus is the real cause of birth palsy. PMID:26624599

Environmental stress and adaptational responses: consequences for human health outcomes.

PubMed

Garruto, Ralph M; Little, Michael A; Weitz, Charles A

2004-12-01

With the dramatic pace of modernization of the world's population, human adaptation as a theoretical construct and paradigm will likely become a focal scientific issue involving scientists from many disciplinary areas during the 21st Century. Macro and micro environments are in rapid flux and human populations are exposed to rapid change. The concept of adaptation, at least in the field of biological anthropology and human biology, will likely remain tied to evolutionary processes and concepts of selection and fitness. In this paper, we discuss the theoretical constructs of adaptation and adaptability and select three current examples from our ongoing research that involve studies of adaptation and evolutionary processes in modernizing populations in different locations worldwide.

Integrated modelling of anthropogenic land-use and land-cover change on the global scale

NASA Astrophysics Data System (ADS)

Schaldach, R.; Koch, J.; Alcamo, J.

2009-04-01

In many cases land-use activities go hand in hand with substantial modifications of the physical and biological cover of the Earth's surface, resulting in direct effects on energy and matter fluxes between terrestrial ecosystems and the atmosphere. For instance, the conversion of forest to cropland is changing climate relevant surface parameters (e.g. albedo) as well as evapotranspiration processes and carbon flows. In turn, human land-use decisions are also influenced by environmental processes. Changing temperature and precipitation patterns for example are important determinants for location and intensity of agriculture. Due to these close linkages, processes of land-use and related land-cover change should be considered as important components in the construction of Earth System models. A major challenge in modelling land-use change on the global scale is the integration of socio-economic aspects and human decision making with environmental processes. One of the few global approaches that integrates functional components to represent both anthropogenic and environmental aspects of land-use change, is the LandSHIFT model. It simulates the spatial and temporal dynamics of the human land-use activities settlement, cultivation of food crops and grazing management, which compete for the available land resources. The rational of the model is to regionalize the demands for area intensive commodities (e.g. crop production) and services (e.g. space for housing) from the country-level to a global grid with the spatial resolution of 5 arc-minutes. The modelled land-use decisions within the agricultural sector are influenced by changing climate and the resulting effects on biomass productivity. Currently, this causal chain is modelled by integrating results from the process-based vegetation model LPJmL model for changing crop yields and net primary productivity of grazing land. Model output of LandSHIFT is a time series of grid maps with land-use/land-cover information that can serve as basis for further impact analysis. An exemplary simulation study with LandSHIFT is presented, based on scenario assumptions from the UNEP Global Environmental Outlook 4. Time horizon of the analysis is the year 2050. Changes of future food production on country level are computed by the agro-economy model IMPACT as a function of demography, economic development and global trade pattern. Together with scenario assumptions on climatic change and population growth, this data serves as model input to compute the changing land-use und land-cover. The continental and global scale model results are then analysed with respect to changes in the spatial pattern of natural vegetation as well as the resulting effects on evapotranspiration processes and land surface parameters. Furthermore, possible linkages of LandSHIFT to the different components of Earth System models (e.g. climate and natural vegetation) are discussed.

Natural and human forcing in recent geomorphic change; case studies in the Rio de la Plata basin.

PubMed

Bonachea, Jaime; Bruschi, Viola M; Hurtado, Martín A; Forte, Luis M; da Silva, Mario; Etcheverry, Ricardo; Cavallotto, José L; Dantas, Marcilene F; Pejon, Osni J; Zuquette, Lázaro V; Bezerra, Maria Angélica de O; Remondo, Juan; Rivas, Victoria; Gómez-Arozamena, José; Fernández, Gema; Cendrero, Antonio

2010-06-01

An analysis of geomorphic system's response to change in human and natural drivers in some areas within the Río de la Plata basin is presented. The aim is to determine whether an acceleration of geomorphic processes has taken place in recent years and, if so, to what extent it is due to natural (climate) or human (land-use) drivers. Study areas of different size, socio-economic and geomorphic conditions have been selected: the Río de la Plata estuary and three sub-basins within its watershed. Sediment cores were extracted and dated ((210)Pb) to determine sedimentation rates since the end of the 19th century. Rates were compared with time series on rainfall as well as human drivers such as population, GDP, livestock load, crop area, energy consumption or cement consumption, all of them related to human capacity to disturb land surface. Data on river discharge were also gathered. Results obtained indicate that sedimentation rates during the last century have remained essentially constant in a remote Andean basin, whereas they show important increases in the other two, particularly one located by the São Paulo metropolitan area. Rates in the estuary are somewhere in between. It appears that there is an intensification of denudation/sedimentation processes within the basin. Rainfall remained stable or varied very slightly during the period analysed and does not seem to explain increases of sedimentation rates observed. Human drivers, particularly those more directly related to capacity to disturb land surface (GDP, energy or cement consumption) show variations that suggest human forcing is a more likely explanation for the observed change in geomorphic processes. It appears that a marked increase in denudation, of a "technological" nature, is taking place in this basin and leading to an acceleration of sediment supply. This is coherent with similar increases observed in other regions. Copyright (c) 2010 Elsevier B.V. All rights reserved.

Age and Visual Information Processing.

ERIC Educational Resources Information Center

Gummerman, Kent; And Others

This paper reports on three studies concerned with aspects of human visual information processing. Study I was an effort to measure the duration of iconic storage using a partial report method in children ranging in age from 6 to 13 years. Study II was designed to detect age related changes in the rate of processing (perceptually encoding) letters…

The evolution of human and ape hand proportions.

PubMed

Almécija, Sergio; Smaers, Jeroen B; Jungers, William L

2015-07-14

Human hands are distinguished from apes by possessing longer thumbs relative to fingers. However, this simple ape-human dichotomy fails to provide an adequate framework for testing competing hypotheses of human evolution and for reconstructing the morphology of the last common ancestor (LCA) of humans and chimpanzees. We inspect human and ape hand-length proportions using phylogenetically informed morphometric analyses and test alternative models of evolution along the anthropoid tree of life, including fossils like the plesiomorphic ape Proconsul heseloni and the hominins Ardipithecus ramidus and Australopithecus sediba. Our results reveal high levels of hand disparity among modern hominoids, which are explained by different evolutionary processes: autapomorphic evolution in hylobatids (extreme digital and thumb elongation), convergent adaptation between chimpanzees and orangutans (digital elongation) and comparatively little change in gorillas and hominins. The human (and australopith) high thumb-to-digits ratio required little change since the LCA, and was acquired convergently with other highly dexterous anthropoids.

The evolution of human and ape hand proportions

PubMed Central

Almécija, Sergio; Smaers, Jeroen B.; Jungers, William L.

2015-01-01

Human hands are distinguished from apes by possessing longer thumbs relative to fingers. However, this simple ape-human dichotomy fails to provide an adequate framework for testing competing hypotheses of human evolution and for reconstructing the morphology of the last common ancestor (LCA) of humans and chimpanzees. We inspect human and ape hand-length proportions using phylogenetically informed morphometric analyses and test alternative models of evolution along the anthropoid tree of life, including fossils like the plesiomorphic ape Proconsul heseloni and the hominins Ardipithecus ramidus and Australopithecus sediba. Our results reveal high levels of hand disparity among modern hominoids, which are explained by different evolutionary processes: autapomorphic evolution in hylobatids (extreme digital and thumb elongation), convergent adaptation between chimpanzees and orangutans (digital elongation) and comparatively little change in gorillas and hominins. The human (and australopith) high thumb-to-digits ratio required little change since the LCA, and was acquired convergently with other highly dexterous anthropoids. PMID:26171589

Understanding and changing human behaviour--antibiotic mainstreaming as an approach to facilitate modification of provider and consumer behaviour.

PubMed

Stålsby Lundborg, Cecilia; Tamhankar, Ashok J

2014-05-01

This paper addresses: 1) Situations where human behaviour is involved in relation to antibiotics, focusing on providers and consumers; 2) Theories about human behaviour and factors influencing behaviour in relation to antibiotics; 3) How behaviour in relation to antibiotics can change; and, 4) Antibiotic mainstreaming as an approach to facilitate changes in human behaviour as regards antibiotics. Influencing human behaviour in relation to antibiotics is a complex process which includes factors like knowledge, attitudes, social norms, socio-economic conditions, peer pressure, experiences, and bio-physical and socio-behavioural environment. Further, key concepts are often perceived in different ways by different individuals. While designing and implementing projects or programmes for behavioural change with respect to antibiotics for professionals or consumers it is helpful to consider theories or models of behaviour change, e.g. the 'stages of change model', including pre-contemplation, contemplation, preparation, action, and maintenance. People in different stages of change are susceptible to different behaviour modification strategies. Application of marketing principles to 'global good', so-called 'social marketing', to improve 'welfare of the individual and society' is gaining increased attention in public health. In conclusion, just providing correct knowledge is not sufficient although it is a pre-requisite for behaviour modification in the desired direction. We can never change the behaviour of any other human, but we can facilitate for others to change their own behaviour. One possibility is to implement 'antibiotic mainstreaming' as a potentially effective way for behaviour modification, i.e. to address consequences for maintaining effective antibiotics in all activities and decisions in society.

Cue Representation and Situational Awareness in Task Analysis

ERIC Educational Resources Information Center

Carl, Diana R.

2009-01-01

Task analysis in human performance technology is used to determine how human performance can be well supported with training, job aids, environmental changes, and other interventions. Early work by Miller (1953) and Gilbert (1969, 1974) addressed cue processing in task execution and recommended cue descriptions in task analysis. Modern task…

Updating Regulations for Human Subjects Research: The New Common Rule Has arrived! What Changes Are Coming?

EPA Science Inventory

The “Common Rule” refers to the federal regulations that govern research involving human subjects. These regulations have been largely unchanged since 1981, while the research they cover has continued to evolve. After a 6-year rulemaking process, the Common Rule was ...

Teaching global and local environmental change through Remote Sensing

NASA Astrophysics Data System (ADS)

Mauri, Emanuela Paola; Rossi, Giovanni

2013-04-01

Human beings perceive the world primarily through their sense of sight. This can explain why the use of images is so important and common in educational materials, in particular for scientific subjects. The development of modern technologies for visualizing the scientific features of the Earth has provided new opportunities for communicating the increasing complexity of science both to the public and in school education. In particular, the use of Earth observation satellites for civil purposes, which started in the 70s, has opened new perspectives in the study of natural phenomena and human impact on the environment; this is particularly relevant for those processes developing on a long term period and on a global scale. Instruments for Remote Sensing increase the power of human sight, giving access to additional information about the physical world, which the human eye could not otherwise perceive. The possibility to observe from a remote perspective significant processes like climate change, ozone depletion, desertification, urban development, makes it possible for observers to better appreciate and experience the complexity of environment. Remote Sensing reveals the impact of human activities on ecosystems: this allows students to understand important concepts like global and local change in much more depth. This poster describes the role and effectiveness of Remote Sensing imagery in scientific education, and its importance towards a better global environmental awareness.

Landscape moderation of biodiversity patterns and processes - eight hypotheses

USDA-ARS?s Scientific Manuscript database

Understanding how landscape characteristics affect local biodiversity patterns and ecological processes is critical for mitigating effects of global environmental change. In this review, we use knowledge gained from human-modified landscapes to suggest the following seven hypotheses, which we hope w...

Cognitive Design for Learning: Cognition and Emotion in the Design Process

ERIC Educational Resources Information Center

Hasebrook, Joachim

2016-01-01

We are so used to accept new technologies being the driver of change and innovation in human computer interfaces (HCI). In our research we focus on the development of innovations as a design process--or design, for short. We also refer to the entire process of creating innovations and putting them to use as "cognitive processes"--or…

Understanding Meta-Decisions: The Key To Effecting Organizational Change. Introduction

ERIC Educational Resources Information Center

Billings, Charles R.

1974-01-01

Discusses the need for individuals to become aware of the decisionmaking process of institutions that directly affect them. Past attempts to effect change within organizational systems are reviewed in terms of the traditional human relations approach and of a systems approach. (Author/WM)

Linking an agency strategic review to increase knowledge management: San Francisco County Human Service Agency.

PubMed

Harrison, Lindsay

2012-01-01

Led by the agency director, the agency engaged in a Strategic Review, based on a comprehensive assessment of agency performance that identified strategies to improve organizational effectiveness through increased data-informed practice and knowledge management. The Strategic Review gathered information on staff perceptions, perceptions of external stakeholders, changing citywide and neighborhood demographics, policy mandates, and budget and workload issues. The need for the review was based upon multiple, substantial changes not addressed in the 2000 Strategic Plan, including the 2004 merger of the Department of Human Services and the Department of Aging and Adult Services, changes among the executive management team, transitions among key political entities, new policy mandates and changing budget allocations. This case study describes the Strategic Review process and content, summarizing key challenges and lessons related to addressing workload demands, fostering positive staff attitudes, balancing internal and external information needs, and integrating data use and planning processes across the agency. Copyright © Taylor & Francis Group, LLC

MicroRNA, mRNA, and protein expression link development and aging in human and macaque brain

PubMed Central

Somel, Mehmet; Guo, Song; Fu, Ning; Yan, Zheng; Hu, Hai Yang; Xu, Ying; Yuan, Yuan; Ning, Zhibin; Hu, Yuhui; Menzel, Corinna; Hu, Hao; Lachmann, Michael; Zeng, Rong; Chen, Wei; Khaitovich, Philipp

2010-01-01

Changes in gene expression levels determine differentiation of tissues involved in development and are associated with functional decline in aging. Although development is tightly regulated, the transition between development and aging, as well as regulation of post-developmental changes, are not well understood. Here, we measured messenger RNA (mRNA), microRNA (miRNA), and protein expression in the prefrontal cortex of humans and rhesus macaques over the species' life spans. We find that few gene expression changes are unique to aging. Instead, the vast majority of miRNA and gene expression changes that occur in aging represent reversals or extensions of developmental patterns. Surprisingly, many gene expression changes previously attributed to aging, such as down-regulation of neural genes, initiate in early childhood. Our results indicate that miRNA and transcription factors regulate not only developmental but also post-developmental expression changes, with a number of regulatory processes continuing throughout the entire life span. Differential evolutionary conservation of the corresponding genomic regions implies that these regulatory processes, although beneficial in development, might be detrimental in aging. These results suggest a direct link between developmental regulation and expression changes taking place in aging. PMID:20647238

Satellite Studies of Cirrus Clouds for Project Fire

NASA Technical Reports Server (NTRS)

1997-01-01

Examine global cloud climatologies for evidence of human caused changes in cloud cover and their effect on the Earth's heat budget through radiative processes. Quantify climatological changes in global cloud cover and estimate their effect on the Earth's heat budget. Improve our knowledge of global cloud cover and its changes through the merging of several satellite data sets.

The human body odor compound androstadienone increases neural conflict coupled to higher behavioral costs during an emotional Stroop task.

PubMed

Hornung, Jonas; Kogler, Lydia; Erb, Michael; Freiherr, Jessica; Derntl, Birgit

2018-05-01

The androgen derivative androstadienone (AND) is a substance found in human sweat and thus may act as human chemosignal. With the current experiment, we aimed to explore in which way AND affects interference processing during an emotional Stroop task which used human faces as target and emotional words as distractor stimuli. This was complemented by functional magnetic resonance imaging (fMRI) to unravel the neural mechanism of AND-action. Based on previous accounts we expected AND to increase neural activation in areas commonly implicated in evaluation of emotional face processing and to change neural activation in brain regions linked to interference processing. For this aim, a total of 80 healthy individuals (oral contraceptive users, luteal women, men) were tested twice on two consecutive days with an emotional Stroop task using fMRI. Our results suggest that AND increases interference processing in brain areas that are heavily recruited during emotional conflict. At the same time, correlation analyses revealed that this neural interference processing was paralleled by higher behavioral costs (response times) with higher interference related brain activation under AND. Furthermore, AND elicited higher activation in regions implicated in emotional face processing including right fusiform gyrus, inferior frontal gyrus and dorsomedial cortex. In this connection, neural activation was not coupled to behavioral outcome. Furthermore, despite previous accounts of increased hypothalamic activation under AND, we were not able to replicate this finding and discuss possible reasons for this discrepancy. To conclude, AND increased interference processing in regions heavily recruited during emotional conflict which was coupled to higher costs in resolving emotional conflicts with stronger interference-related brain activation under AND. At the moment it remains unclear whether these effects are due to changes in conflict detection or resolution. However, evidence most consistently suggests that AND does not draw attention to the most potent socio-emotional information (human faces) but rather highlights representations of emotional words. Copyright © 2018 Elsevier Inc. All rights reserved.

Appropriate technology and climate change adaptation

NASA Astrophysics Data System (ADS)

Bandala, Erick R.; Patiño-Gomez, Carlos

2016-02-01

Climate change is emerging as the greatest significant environmental problem for the 21st Century and the most important global challenge faced by human kind. Based on evidence recognized by the international scientific community, climate change is already an unquestionable reality, whose first effects are beginning to be measured. Available climate projections and models can assist in anticipating potential far-reaching consequences for development processes. Climatic transformations will impact the environment, biodiversity and water resources, putting several productive processes at risk; and will represent a threat to public health and water availability in quantity and quality.

Physiological principles of vestibular function on earth and in space

NASA Technical Reports Server (NTRS)

Minor, L. B.

1998-01-01

Physiological mechanisms underlying vestibular function have important implications for our ability to understand, predict, and modify balance processes during and after spaceflight. The microgravity environment of space provides many unique opportunities for studying the effects of changes in gravitoinertial force on structure and function of the vestibular system. Investigations of basic vestibular physiology and of changes in reflexes occurring as a consequence of exposure to microgravity have important implications for diagnosis and treatment of vestibular disorders in human beings. This report reviews physiological principles underlying control of vestibular processes on earth and in space. Information is presented from a functional perspective with emphasis on signals arising from labyrinthine receptors. Changes induced by microgravity in linear acceleration detected by the vestibulo-ocular reflexes. Alterations of the functional requirements for postural control in space are described. Areas of direct correlation between studies of vestibular reflexes in microgravity and vestibular disorders in human beings are discussed.

Interacting Physical and Biological Processes Affecting Nutrient Transport Through Human Dominated Landscapes

NASA Astrophysics Data System (ADS)

Finlay, J. C.

2015-12-01

Human activities increasingly dominate biogeochemical cycles of limiting nutrients on Earth. Urban and agricultural landscapes represent the largest sources of excess nutrients that drive water quality degradation. The physical structure of both urban and agricultural watersheds has been extensively modified, and these changes have large impacts on water and nutrient transport. Despite strong physical controls over nutrient transport in human dominated landscapes, biological processes play important roles in determining the fates of both nitrogen and phosphorus. This talk uses examples from research in urban and agricultural watersheds in the Midwestern USA to illustrate interactions of physical and biological controls over nutrient cycles that have shifted nitrogen (N) and phosphorus (P) sources and cycling in unexpected ways in response to management changes. In urban watersheds, efforts to improve water quality have been hindered by legacy sources of phosphorus added to storm water through transport to drainage systems by vegetation. Similarly, reductions in field erosion in agricultural watersheds have not led to major reductions in phosphorus transport, because of continued release of biological sources of P. Where management of phosphorus has been most effective in reducing eutrophication of lakes, decreases in N removal processes have led to long term increases in N concentration and transport. Together, these examples show important roles for biological processes affecting nutrient movement in highly modified landscapes. Consideration of the downstream physical and biological responses of management changes are thus critical toward identification of actions that will most effectively reduce excess nutrients watersheds and coastal zones.

Contemporary changes of water resources, water and land use in Central Asia based on observations and modeling.

NASA Astrophysics Data System (ADS)

Shiklomanov, A. I.; Prousevitch, A.; Sokolik, I. N.; Lammers, R. B.

2015-12-01

Water is a key agent in Central Asia ultimately determining human well-being, food security, and economic development. There are complex interplays among the natural and anthropogenic drivers effecting the regional hydrological processes and water availability. Analysis of the data combined from regional censuses and remote sensing shows a decline in areas of arable and irrigated lands and a significant decrease in availability of arable and irrigated lands per capita across all Central Asian countries since the middle of 1990thas the result of post-Soviet transformation processes. This change could lead to considerable deterioration in food security and human system sustainability. The change of political situation in the region has also resulted in the escalated problems of water demand between countries in international river basins. We applied the University of New Hampshire - Water Balance Model - Transport from Anthropogenic and Natural Systems (WBM-TrANS) to understand the consequences of changes in climate, water and land use on regional hydrological processes and water availability. The model accounts for sub-pixel land cover types, glacier and snow-pack accumulation/melt across sub-pixel elevation bands, anthropogenic water use (e.g. domestic and industrial consumption, and irrigation for most of existing crop types), hydro-infrastructure for inter-basin water transfer and reservoir/dam regulations. A suite of historical climate re-analysis and temporal extrapolation of MIRCA-2000 crop structure datasets has been used in WBM-TrANS for this project. A preliminary analysis of the model simulations over the last 30 years has shown significant spatial and temporal changes in hydrology and water availability for crops and human across the region due to climatic and anthropogenic causes. We found that regional water availability is mostly impacted by changes in extents and efficiency of crop filed irrigation, especially in highly arid areas of Central Asia, changes in winter snow storage, and shifts in seasonality and intensity of glacier melt waters driven by climatic changes.

Non-Traditional Displays for Mission Monitoring

NASA Technical Reports Server (NTRS)

Trujillo, Anna C.; Schutte, Paul C.

1999-01-01

Advances in automation capability and reliability have changed the role of humans from operating and controlling processes to simply monitoring them for anomalies. However, humans are traditionally bad monitors of highly reliable systems over time. Thus, the human is assigned a task for which he is ill equipped. We believe that this has led to the dominance of human error in process control activities such as operating transportation systems (aircraft and trains), monitoring patient health in the medical industry, and controlling plant operations. Research has shown, though, that an automated monitor can assist humans in recognizing and dealing with failures. One possible solution to this predicament is to use a polar-star display that will show deviations from normal states based on parameters that are most indicative of mission health.

The human as a detector of changes in variance and bandwidth

NASA Technical Reports Server (NTRS)

Curry, R. E.; Govindaraj, T.

1977-01-01

The detection of changes in random process variance and bandwidth was studied. Psychophysical thresholds for these two parameters were determined using an adaptive staircase technique for second order random processes at two nominal periods (1 and 3 seconds) and damping ratios (0.2 and 0.707). Thresholds for bandwidth changes were approximately 9% of nominal except for the (3sec,0.2) process which yielded thresholds of 12%. Variance thresholds averaged 17% of nominal except for the (3sec,0.2) process in which they were 32%. Detection times for suprathreshold changes in the parameters may be roughly described by the changes in RMS velocity of the process. A more complex model is presented which consists of a Kalman filter designed for the nominal process using velocity as the input, and a modified Wald sequential test for changes in the variance of the residual. The model predictions agree moderately well with the experimental data. Models using heuristics, e.g. level crossing counters, were also examined and are found to be descriptive but do not afford the unification of the Kalman filter/sequential test model used for changes in mean.

Compounding Impacts of Human-Induced Water Stress and Climate Change on Water Availability

NASA Technical Reports Server (NTRS)

Mehran, Ali; AghaKouchak, Amir; Nakhjiri, Navid; Stewardson, Michael J.; Peel, Murray C.; Phillips, Thomas J.; Wada, Yoshihide; Ravalico, Jakin K.

2017-01-01

The terrestrial phase of the water cycle can be seriously impacted by water management and human water use behavior (e.g., reservoir operation, and irrigation withdrawals). Here we outline a method for assessing water availability in a changing climate, while explicitly considering anthropogenic water demand scenarios and water supply infrastructure designed to cope with climatic extremes. The framework brings a top-down and bottom-up approach to provide localized water assessment based on local water supply infrastructure and projected water demands. When our framework is applied to southeastern Australia we find that, for some combinations of climatic change and water demand, the region could experience water stress similar or worse than the epic Millennium Drought. We show considering only the influence of future climate on water supply, and neglecting future changes in water demand and water storage augmentation might lead to opposing perspectives on future water availability. While human water use can significantly exacerbate climate change impacts on water availability, if managed well, it allows societies to react and adapt to a changing climate. The methodology we present offers a unique avenue for linking climatic and hydrologic processes to water resource supply and demand management and other human interactions.

Compounding Impacts of Human-Induced Water Stress and Climate Change on Water Availability.

PubMed

Mehran, Ali; AghaKouchak, Amir; Nakhjiri, Navid; Stewardson, Michael J; Peel, Murray C; Phillips, Thomas J; Wada, Yoshihide; Ravalico, Jakin K

2017-07-24

The terrestrial phase of the water cycle can be seriously impacted by water management and human water use behavior (e.g., reservoir operation, and irrigation withdrawals). Here we outline a method for assessing water availability in a changing climate, while explicitly considering anthropogenic water demand scenarios and water supply infrastructure designed to cope with climatic extremes. The framework brings a top-down and bottom-up approach to provide localized water assessment based on local water supply infrastructure and projected water demands. When our framework is applied to southeastern Australia we find that, for some combinations of climatic change and water demand, the region could experience water stress similar or worse than the epic Millennium Drought. We show considering only the influence of future climate on water supply, and neglecting future changes in water demand and water storage augmentation might lead to opposing perspectives on future water availability. While human water use can significantly exacerbate climate change impacts on water availability, if managed well, it allows societies to react and adapt to a changing climate. The methodology we present offers a unique avenue for linking climatic and hydrologic processes to water resource supply and demand management and other human interactions.

The Psychology of Safety

NASA Technical Reports Server (NTRS)

Anderson, Brenda Lindley

2011-01-01

Many studies of mishaps show that human error is a factor in a significant majority of accidents. Trying to decide how to change human behavior to be safer is generally the biggest challenge of any safety program. However, understanding the human psyche is the first step to changing behavior. Many studies focus on the before and after of an accident, but what about the thoughts of a person in the commission of an unsafe act? This is a less understood area. Examining it reveals why it is not well comprehended. This paper attempts to examine a part of the thought process, with an eye to helping influence people to less hurtful actions.

"Reconstructing a Sense of Self": Trauma and Coping Among Returned Women Survivors of Human Trafficking in Vietnam.

PubMed

Le, PhuongThao D

2017-03-01

Survivors of human trafficking who return to their community of origin must cope with the trauma they experienced as victims as well as the conditions that contributed to their trafficking vulnerabilities. In this article, I examine the psychosocial adjustment process among women survivors of trafficking who returned to Vietnam. Supplemented by participation observation, thematic analysis of in-depth interviews with survivors revealed that throughout the trafficking process, the women experienced multiple abuses and changes in relationships and environments. The women coped by navigating a process of "reconstructing a sense of self," seeking congruence between their self-understandings and the changing contextual factors while exhibiting three main coping strategies: regulating emotional expression and thought, creating opportunities within constraints, and relating to cultural schemas. The findings underscore the importance of considering contextual factors such as cultural norms and societal values in efforts to assist trafficked survivors reintegrate into their communities.

[AGING AND OSTEOARTHRITIS. CHRONIC NONSPECIFIC INFLAMMATION AS A LINK BETWEEN AGING AND OSTEOARTHRITIS (REVIEW)].

PubMed

Mendel, O I; Luchihina, L V; Mendel, W

2015-01-01

This article presents review on the processes underlying aging and the most common age-associated diseases. Special attention is given to the role of chronic nonspecific inflammation. Based on the literature data it was demonstrated that aging and osteoarthritis have the same basic molecular and cellular mechanisms, among which general are cascades intracellular transcription chronic nonspecific inflammation and metabolic disturbances plays an important role. It is concluded that the process of normal aging is not a disease, but makes the human body, and particularly the musculoskeletal system, susceptible to age-associated changes. Number of changes in the human body that accompany the aging process, and play a role in the development and progression of OA, are potentially reversible, regardless of age (eg, chronic non-specific inflammation), and can be considered as a possible entry points for the effective prevention and complex therapy of OA in elderly people.

Using remote sensing to monitor past changes and assess future scenarios for the Sacramento-San Joaquin River Delta waterways, California USA

NASA Astrophysics Data System (ADS)

Santos, Maria J.; Hestir, Erin; Khanna, Shruti; Ustin, Susan L.

2017-04-01

Historically, deltas have been extensively affected both by natural processes and human intervention. Thus, understanding drivers, predicting impacts and optimizing solutions to delta problems requires a holistic approach spanning many sectors, disciplines and fields of expertise. Deltas are ideal model systems to understand the effects of the interaction between social and ecological domains, as they face unprecedented disturbances and threats to their biological and ecological sustainability. The challenge for deltas is to meet the goals of supporting biodiversity and ecosystem processes while also provisioning fresh water resources for human use. We provide an overview of the last 150 years of the Sacramento-San Joaquin River delta, where we illustrate the parallel process of an increase in disturbances, by particularly zooming in on the current cascading effects of invasive species on geophysical and biological processes. Using remote sensing data coupled with in situ measurements of water quality, turbidity, and species presence we show how the spread and persistence of aquatic invasive species affects sedimentation processes and ecosystem functioning. Our results show that the interactions between the biological and physical conditions in the Delta affect the trajectory of dominance by native and invasive aquatic plant species. Trends in growth and community characteristics associated with predicted impacts of climate change (sea level rise, warmer temperatures, changes in the hydrograph with high winter and low summer outflows) do not provide simple predictions. Individually, the impact of specific environmental changes on the biological components can be predicted, however it is the complex interactions of biological communities with the suite of physical changes that make predictions uncertain. Systematic monitoring is critical to provide the data needed to document and understand change of these delta systems, and to identify successful adaptation strategies.

Combining fMRI and behavioral measures to examine the process of human learning.

PubMed

Karuza, Elisabeth A; Emberson, Lauren L; Aslin, Richard N

2014-03-01

Prior to the advent of fMRI, the primary means of examining the mechanisms underlying learning were restricted to studying human behavior and non-human neural systems. However, recent advances in neuroimaging technology have enabled the concurrent study of human behavior and neural activity. We propose that the integration of behavioral response with brain activity provides a powerful method of investigating the process through which internal representations are formed or changed. Nevertheless, a review of the literature reveals that many fMRI studies of learning either (1) focus on outcome rather than process or (2) are built on the untested assumption that learning unfolds uniformly over time. We discuss here various challenges faced by the field and highlight studies that have begun to address them. In doing so, we aim to encourage more research that examines the process of learning by considering the interrelation of behavioral measures and fMRI recording during learning. Copyright © 2013 Elsevier Inc. All rights reserved.

Combining fMRI and Behavioral Measures to Examine the Process of Human Learning

PubMed Central

Karuza, Elisabeth A.; Emberson, Lauren L.; Aslin, Richard N.

2013-01-01

Prior to the advent of fMRI, the primary means of examining the mechanisms underlying learning were restricted to studying human behavior and non-human neural systems. However, recent advances in neuroimaging technology have enabled the concurrent study of human behavior and neural activity. We propose that the integration of behavioral response with brain activity provides a powerful method of investigating the process through which internal representations are formed or changed. Nevertheless, a review of the literature reveals that many fMRI studies of learning either (1) focus on outcome rather than process or (2) are built on the untested assumption that learning unfolds uniformly over time. We discuss here various challenges faced by the field and highlight studies that have begun to address them. In doing so, we aim to encourage more research that examines the process of learning by considering the interrelation of behavioral measures and fMRI recording during learning. PMID:24076012

Health promotion by social cognitive means.

PubMed

Bandura, Albert

2004-04-01

This article examines health promotion and disease prevention from the perspective of social cognitive theory. This theory posits a multifaceted causal structure in which self-efficacy beliefs operate together with goals, outcome expectations, and perceived environmental impediments and facilitators in the regulation of human motivation, behavior, and well-being. Belief in one's efficacy to exercise control is a common pathway through which psychosocial influences affect health functioning. This core belief affects each of the basic processes of personal change--whether people even consider changing their health habits, whether they mobilize the motivation and perseverance needed to succeed should they do so, their ability to recover from setbacks and relapses, and how well they maintain the habit changes they have achieved. Human health is a social matter, not just an individual one. A comprehensive approach to health promotion also requires changing the practices of social systems that have widespread effects on human health.

Human factors certification in the development of future air traffic control systems

NASA Technical Reports Server (NTRS)

Evans, Alyson E.

1994-01-01

If human factors certification of aviation technologies aims to encompass the wide range of issues which need to be addressed for any new system, then human factors involvement must be present throughout the whole design process in a manner which relates to final certification. A certification process cannot simply be applied to the final product of design. Standards and guidelines will be required by designers at the outset of design for reference in preparing for certification. The most effective use of human factors principles, methods, and measures is made as part of an iterative design process, leading to a system which reflects these as far as possible. This particularly applies where the technology is complex and may be represented by a number of components or sub-systems. Some aspects of the system are best certified during early prototyping, when there is still scope to make changes to software or hardware. At this stage in design, financial and/or time pressures will not rule out the possibility of necessary changes, as may be the case later. Other aspects of the system will be best certified during the final phases of design when the system is in a more complete form and in a realistic environment.

Postmortem succession of gut microbial communities in deceased human subjects

PubMed Central

Hauther, Kathleen A.

2017-01-01

The human microbiome has demonstrated an importance for the health and functioning in living individuals. However, the fate of the microbiome after death is less understood. In addition to a better understanding of microbe-mediated decomposition processes, postmortem succession of human-associated microbial communities has been suggested as a possible forensic tool for estimating time since death, or postmortem interval (PMI). The objective of our study was to document postmortem changes in human gut bacterial communities. Gut microflora were repeatedly sampled from the caeca of cadavers as they decayed under natural environmental conditions. 16S rRNA gene amplicon sequencing revealed that over time, bacterial richness significantly increased (rs = 0.449) while diversity decreased (rs =  − 0.701). The composition of gut bacterial communities changed in a similar manner over time towards a common decay community. OTUs belonging to Bacteroidales (Bacteroides, Parabacteroides) significantly declined while Clostridiales (Clostridium, Anaerosphaera) and the fly-associated Gammaproteobacteria Ignatzschineria and Wohlfahrtiimonas increased. Our examination of human caeca microflora in decomposing cadavers adds to the growing literature on postmortem microbial communities, which will ultimately contribute to a better understanding of decomposition processes. PMID:28626612

Cogenerating a Competency-based HRM Degree: A Model and Some Lessons from Experience.

ERIC Educational Resources Information Center

Wooten, Kevin C.; Elden, Max

2001-01-01

A competency-based degree program in human resource management was co-generated by six groups of stakeholders who synthesized competency models using group decision support software. The program focuses on core human resource processes, general business management, strategic decision making and problem solving, change management, and personal…

Human Capital: A Self-Assessment Checklist for Agency Leaders. Version 1.

ERIC Educational Resources Information Center

Comptroller General of the U.S., Washington, DC.

This document presents and discusses a self-assessment checklist that the General Accounting Office (GAO) developed to enable agency leaders to examine their human capital efforts through a process consisting of the following stages: analyze and plan; implement change; and evaluate and continuously improve. The preface defines the term "human…

Integrating CAD/CAM in Automation and Materials Handling

ERIC Educational Resources Information Center

Deal, Walter F.; Jones, Catherine E.

2012-01-01

Humans by their very nature are users of tools, materials, and processes as a part of their survival and existence. As humans have progressed over time, their civilizations and societies have changed beyond imagination and have moved from hunters and gatherers of food and materials for survival to sophisticated societies with complex social and…

Human Capability, Mild Perfectionism and Thickened Educational Praxis

ERIC Educational Resources Information Center

Walker, Melanie

2008-01-01

This paper argues for a mild perfectionism in applying Amartya Sen's capability approach for an education transformative of student agency and well-being. Key to the paper is the significance of education as a process of being and becoming in the future, and education's fundamental objective of a positively changed human being. The capability…

Social, moral, and temporal qualities: Pre-service teachers' considerations of evolution and creation

NASA Astrophysics Data System (ADS)

Hahn, Deirdre

The introduction of the theories of evolution into public education has created a history of misinterpretation and uncertainty about its application to understanding deep time and human origins. Conceptions about negative social and moral outcomes of evolution itself along with cognitive temporal constraints may be difficult for many individuals to uncouple from the scientific theory, serving to provoke the ongoing debate about the treatment of evolution in science education. This debate about teaching evolution is strongly influenced by groups who strive to add creationism to the science curriculum for a balanced treatment of human origins and to mediate implied negative social and moral outcomes of evolution. Individual conceptualization of evolution and creation may influence the choice of college students to teach science. This study is designed to examine if pre-service teachers' conceptualize an evolutionary and creationist process of human development using certain social, moral or temporal patterns; and if the patterns follow a negative conceptual theme. The pilot study explored 21 pre-service teachers' conceptual representation of an evolutionary process through personal narratives. Participants tended to link evolutionary changes with negative social and moral consequences and seemed to have difficulty envisioning change over time. The pilot study was expanded to include a quantitative examination of attribute patterns of an evolutionary and creationist developmental process. Seventy-three pre-service teachers participated in the second experiment and tended to fall evenly along a continuum of creationist and evolutionist beliefs about life. Using a chi-square and principle components analysis, participants were found to map concepts of evolution and creation onto each other using troubling attributes of development to distinguish negative change over time. A strong negative social and moral pattern of human development was found in the creation condition, though only a vague negative human developmental process was found for the evolution condition. Based on these results, pre-service teachers may not use evolution as a viable explanation of human origins, which may serve to contribute to evolution theory debates and discourage pre-service teachers' choice of being science instructors.

21st century United States emissions mitigation could increase water stress more than the climate change it is mitigating.

PubMed

Hejazi, Mohamad I; Voisin, Nathalie; Liu, Lu; Bramer, Lisa M; Fortin, Daniel C; Hathaway, John E; Huang, Maoyi; Kyle, Page; Leung, L Ruby; Li, Hong-Yi; Liu, Ying; Patel, Pralit L; Pulsipher, Trenton C; Rice, Jennie S; Tesfa, Teklu K; Vernon, Chris R; Zhou, Yuyu

2015-08-25

There is evidence that warming leads to greater evapotranspiration and surface drying, thus contributing to increasing intensity and duration of drought and implying that mitigation would reduce water stresses. However, understanding the overall impact of climate change mitigation on water resources requires accounting for the second part of the equation, i.e., the impact of mitigation-induced changes in water demands from human activities. By using integrated, high-resolution models of human and natural system processes to understand potential synergies and/or constraints within the climate-energy-water nexus, we show that in the United States, over the course of the 21st century and under one set of consistent socioeconomics, the reductions in water stress from slower rates of climate change resulting from emission mitigation are overwhelmed by the increased water stress from the emissions mitigation itself. The finding that the human dimension outpaces the benefits from mitigating climate change is contradictory to the general perception that climate change mitigation improves water conditions. This research shows the potential for unintended and negative consequences of climate change mitigation.

A Successful Infusion Process for Enabling Lunar Exploration Technologies

NASA Technical Reports Server (NTRS)

Over, Ann P.; Klem, Mark K.; Motil, Susan M.

2008-01-01

The NASA Vision for Space Exploration begins with a more reliable flight capability to the International Space Station and ends with sending humans to Mars. An important stepping stone on the path to Mars encompasses human missions to the Moon. There is little doubt throughout the stakeholder community that new technologies will be required to enable this Vision. However, there are many factors that influence the ability to successfully infuse any technology including the technical risk, requirement and development schedule maturity, and, funds available. This paper focuses on effective infusion processes that have been used recently for the technologies in development for the lunar exploration flight program, Constellation. Recent successes with Constellation customers are highlighted for the Exploration Technology Development Program (ETDP) Projects managed by NASA Glenn Research Center (GRC). Following an overview of the technical context of both the flight program and the technology capability mapping, the process is described for how to effectively build an integrated technology infusion plan. The process starts with a sound risk development plan and is completed with an integrated project plan, including content, schedule and cost. In reality, the available resources for this development are going to change over time, necessitating some level of iteration in the planning. However, the driving process is based on the initial risk assessment, which changes only when the overall architecture changes, enabling some level of stability in the process.

Active glass-type human augmented cognition system considering attention and intention

NASA Astrophysics Data System (ADS)

Kim, Bumhwi; Ojha, Amitash; Lee, Minho

2015-10-01

Human cognition is the result of an interaction of several complex cognitive processes with limited capabilities. Therefore, the primary objective of human cognitive augmentation is to assist and expand these limited human cognitive capabilities independently or together. In this study, we propose a glass-type human augmented cognition system, which attempts to actively assist human memory functions by providing relevant, necessary and intended information by constantly assessing intention of the user. To achieve this, we exploit selective attention and intention processes. Although the system can be used in various real-life scenarios, we test the performance of the system in a person identity scenario. To detect the intended face, the system analyses the gaze points and change in pupil size to determine the intention of the user. An assessment of the gaze points and change in pupil size together indicates that the user intends to know the identity and information about the person in question. Then, the system retrieves several clues through speech recognition system and retrieves relevant information about the face, which is finally displayed through head-mounted display. We present the performance of several components of the system. Our results show that the active and relevant assistance based on users' intention significantly helps the enhancement of memory functions.

Dynamics of scene representations in the human brain revealed by magnetoencephalography and deep neural networks.

PubMed

Martin Cichy, Radoslaw; Khosla, Aditya; Pantazis, Dimitrios; Oliva, Aude

2017-06-01

Human scene recognition is a rapid multistep process evolving over time from single scene image to spatial layout processing. We used multivariate pattern analyses on magnetoencephalography (MEG) data to unravel the time course of this cortical process. Following an early signal for lower-level visual analysis of single scenes at ~100ms, we found a marker of real-world scene size, i.e. spatial layout processing, at ~250ms indexing neural representations robust to changes in unrelated scene properties and viewing conditions. For a quantitative model of how scene size representations may arise in the brain, we compared MEG data to a deep neural network model trained on scene classification. Representations of scene size emerged intrinsically in the model, and resolved emerging neural scene size representation. Together our data provide a first description of an electrophysiological signal for layout processing in humans, and suggest that deep neural networks are a promising framework to investigate how spatial layout representations emerge in the human brain. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

Compendium of Immune Signatures Identifies Conserved and Species-Specific Biology in Response to Inflammation.

PubMed

Godec, Jernej; Tan, Yan; Liberzon, Arthur; Tamayo, Pablo; Bhattacharya, Sanchita; Butte, Atul J; Mesirov, Jill P; Haining, W Nicholas

2016-01-19

Gene-expression profiling has become a mainstay in immunology, but subtle changes in gene networks related to biological processes are hard to discern when comparing various datasets. For instance, conservation of the transcriptional response to sepsis in mouse models and human disease remains controversial. To improve transcriptional analysis in immunology, we created ImmuneSigDB: a manually annotated compendium of ∼5,000 gene-sets from diverse cell states, experimental manipulations, and genetic perturbations in immunology. Analysis using ImmuneSigDB identified signatures induced in activated myeloid cells and differentiating lymphocytes that were highly conserved between humans and mice. Sepsis triggered conserved patterns of gene expression in humans and mouse models. However, we also identified species-specific biological processes in the sepsis transcriptional response: although both species upregulated phagocytosis-related genes, a mitosis signature was specific to humans. ImmuneSigDB enables granular analysis of transcriptomic data to improve biological understanding of immune processes of the human and mouse immune systems. Copyright © 2016 Elsevier Inc. All rights reserved.

Preface: Ecosystem services, ecosystem health and human communities

NASA Astrophysics Data System (ADS)

Plag, Hans-Peter

2018-04-01

This special issue contains a collection of manuscripts that were originally intended to be included in the special issue on "Physics and Economics of Ecosystem Services Flows" (Volume 101, guest editors H. Su, J. Dong and S. Nagarajan) and "Biogeochemical Processes in the Changing Wetland Environment" (Volume 103, guest editors J. Bai, L. Huang and H. Gao). All of them are addressing issues related to ecosystem services in different settings. Ecosystem services are of high value for both the ecosystems and human communities, and understanding the impacts of environmental processes and human activities on ecosystems is of fundamental importance for the preservation of these services.

Evolution of cultural traits occurs at similar relative rates in different world regions.

PubMed

Currie, Thomas E; Mace, Ruth

2014-11-22

A fundamental issue in understanding human diversity is whether or not there are regular patterns and processes involved in cultural change. Theoretical and mathematical models of cultural evolution have been developed and are increasingly being used and assessed in empirical analyses. Here, we test the hypothesis that the rates of change of features of human socio-cultural organization are governed by general rules. One prediction of this hypothesis is that different cultural traits will tend to evolve at similar relative rates in different world regions, despite the unique historical backgrounds of groups inhabiting these regions. We used phylogenetic comparative methods and systematic cross-cultural data to assess how different socio-cultural traits changed in (i) island southeast Asia and the Pacific, and (ii) sub-Saharan Africa. The relative rates of change in these two regions are significantly correlated. Furthermore, cultural traits that are more directly related to external environmental conditions evolve more slowly than traits related to social structures. This is consistent with the idea that a form of purifying selection is acting with greater strength on these more environmentally linked traits. These results suggest that despite contingent historical events and the role of humans as active agents in the historical process, culture does indeed evolve in ways that can be predicted from general principles.

Evolution of cultural traits occurs at similar relative rates in different world regions

PubMed Central

Currie, Thomas E.; Mace, Ruth

2014-01-01

A fundamental issue in understanding human diversity is whether or not there are regular patterns and processes involved in cultural change. Theoretical and mathematical models of cultural evolution have been developed and are increasingly being used and assessed in empirical analyses. Here, we test the hypothesis that the rates of change of features of human socio-cultural organization are governed by general rules. One prediction of this hypothesis is that different cultural traits will tend to evolve at similar relative rates in different world regions, despite the unique historical backgrounds of groups inhabiting these regions. We used phylogenetic comparative methods and systematic cross-cultural data to assess how different socio-cultural traits changed in (i) island southeast Asia and the Pacific, and (ii) sub-Saharan Africa. The relative rates of change in these two regions are significantly correlated. Furthermore, cultural traits that are more directly related to external environmental conditions evolve more slowly than traits related to social structures. This is consistent with the idea that a form of purifying selection is acting with greater strength on these more environmentally linked traits. These results suggest that despite contingent historical events and the role of humans as active agents in the historical process, culture does indeed evolve in ways that can be predicted from general principles PMID:25297866

Changes in gene expression associated with reproductive maturation in wild female baboons.

PubMed

Babbitt, Courtney C; Tung, Jenny; Wray, Gregory A; Alberts, Susan C

2012-01-01

Changes in gene expression during development play an important role in shaping morphological and behavioral differences, including between humans and nonhuman primates. Although many of the most striking developmental changes occur during early development, reproductive maturation represents another critical window in primate life history. However, this process is difficult to study at the molecular level in natural primate populations. Here, we took advantage of ovarian samples made available through an unusual episode of human-wildlife conflict to identify genes that are important in this process. Specifically, we used RNA sequencing (RNA-Seq) to compare genome-wide gene expression patterns in the ovarian tissue of juvenile and adult female baboons from Amboseli National Park, Kenya. We combined this information with prior evidence of selection occurring on two primate lineages (human and chimpanzee). We found that in cases in which genes were both differentially expressed over the course of ovarian maturation and also linked to lineage-specific selection this selective signature was much more likely to occur in regulatory regions than in coding regions. These results suggest that adaptive change in the development of the primate ovary may be largely driven at the mechanistic level by selection on gene regulation, potentially in relationship to the physiology or timing of female reproductive maturation.

The interaction of neutral evolutionary processes with climatically-driven adaptive changes in the 3D shape of the human os coxae.

PubMed

Betti, Lia; von Cramon-Taubadel, Noreen; Manica, Andrea; Lycett, Stephen J

2014-08-01

Differences in the breadth of the pelvis among modern human populations and among extinct hominin species have often been interpreted in the light of thermoregulatory adaptation, whereby a larger pelvic girdle would help preserve body temperature in cold environments while a narrower pelvis would help dissipate heat in tropical climates. There is, however, a theoretical problem in interpreting a pattern of variation as evidence of selection without first accounting for the effects of neutral evolutionary processes (i.e., mutation, genetic drift and migration). Here, we analyse 3D configurations of 27 landmarks on the os coxae of 1494 modern human individuals representing 30 male and 23 female populations from five continents and a range of climatic conditions. We test for the effects of climate on the size and shape of the pelvic bone, while explicitly accounting for population history (i.e., geographically-mediated gene flow and genetic drift). We find that neutral processes account for a substantial proportion of shape variance in the human os coxae in both sexes. Beyond the neutral pattern due to population history, temperature is a significant predictor of shape and size variation in the os coxae, at least in males. The effect of climate on the shape of the pelvic bone, however, is comparatively limited, explaining only a small percentage of shape variation in males and females. In accordance with previous hypotheses, the size of the os coxae tends to increase with decreasing temperature, although the significance of the association is reduced when population history is taken into account. In conclusion, the shape and size of the human os coxae reflect both neutral evolutionary processes and climatically-driven adaptive changes. Neutral processes have a substantial effect on pelvic variation, suggesting such factors will need to be taken into account in future studies of human and fossil hominin coxal variation. Copyright © 2014 Elsevier Ltd. All rights reserved.

Understanding scale dependency of climatic processes with diarrheal disease

NASA Astrophysics Data System (ADS)

Nasr Azadani, F.; Jutla, A.; Akanda, A. S. S.; Colwell, R. R.

2015-12-01

The issue of scales in linking climatic processes with diarrheal diseases is perhaps one of the most challenging aspect to develop any predictive algorithm for outbreaks and to understand impacts of changing climate. Majority of diarrheal diseases have shown to be strongly associated with climate modulated environmental processes where pathogens survive. Using cholera as an example of characteristic diarrheal diseases, this study will provide methodological insights on dominant scale variability in climatic processes that are linked with trigger and transmission of disease. Cholera based epidemiological models use human to human interaction as a main transmission mechanism, however, environmental conditions for creating seasonality in outbreaks is not explicitly modeled. For example, existing models cannot create seasonality, unless some of the model parameters are a-priori chosen to vary seasonally. A systems based feedback approach will be presented to understand role of climatic processes on trigger and transmission disease. In order to investigate effect of changing climate on cholera, a downscaling approach using support vector machine will be used. Our preliminary results using three climate models, ECHAM5, GFDL, and HADCM show that varying modalities in future cholera outbreaks.

Scoring of Decomposition: A Proposed Amendment to the Method When Using a Pig Model for Human Studies.

PubMed

Keough, Natalie; Myburgh, Jolandie; Steyn, Maryna

2017-07-01

Decomposition studies often use pigs as proxies for human cadavers. However, differences in decomposition sequences/rates relative to humans have not been scientifically examined. Descriptions of five main decomposition stages (humans) were developed and refined by Galloway and later by Megyesi. However, whether these changes/processes are alike in pigs is unclear. Any differences can have significant effects when pig models are used for human PMI estimation. This study compared human decomposition models to the changes observed in pigs. Twenty pigs (50-90 kg) were decomposed over five months and decompositional features recorded. Total body scores (TBS) were calculated. Significant differences were observed during early decomposition between pigs and humans. An amended scoring system to be used in future studies was developed. Standards for PMI estimation derived from porcine models may not directly apply to humans and may need adjustment. Porcine models, however, remain valuable to study variables influencing decomposition. © 2016 American Academy of Forensic Sciences.

Wildlife disease prevalence in human-modified landscapes.

PubMed

Brearley, Grant; Rhodes, Jonathan; Bradley, Adrian; Baxter, Greg; Seabrook, Leonie; Lunney, Daniel; Liu, Yan; McAlpine, Clive

2013-05-01

Human-induced landscape change associated with habitat loss and fragmentation places wildlife populations at risk. One issue in these landscapes is a change in the prevalence of disease which may result in increased mortality and reduced fecundity. Our understanding of the influence of habitat loss and fragmentation on the prevalence of wildlife diseases is still in its infancy. What is evident is that changes in disease prevalence as a result of human-induced landscape modification are highly variable. The importance of infectious diseases for the conservation of wildlife will increase as the amount and quality of suitable habitat decreases due to human land-use pressures. We review the experimental and observational literature of the influence of human-induced landscape change on wildlife disease prevalence, and discuss disease transmission types and host responses as mechanisms that are likely to determine the extent of change in disease prevalence. It is likely that transmission dynamics will be the key process in determining a pathogen's impact on a host population, while the host response may ultimately determine the extent of disease prevalence. Finally, we conceptualize mechanisms and identify future research directions to increase our understanding of the relationship between human-modified landscapes and wildlife disease prevalence. This review highlights that there are rarely consistent relationships between wildlife diseases and human-modified landscapes. In addition, variation is evident between transmission types and landscape types, with the greatest positive influence on disease prevalence being in urban landscapes and directly transmitted disease systems. While we have a limited understanding of the potential influence of habitat loss and fragmentation on wildlife disease, there are a number of important areas to address in future research, particularly to account for the variability in increased and decreased disease prevalence. Previous studies have been based on a one-dimensional comparison between unmodified and modified sites. What is lacking are spatially and temporally explicit quantitative approaches which are required to enable an understanding of the range of key causal mechanisms and the reasons for variability. This is particularly important for replicated studies across different host-pathogen systems. Furthermore, there are few studies that have attempted to separate the independent effects of habitat loss and fragmentation on wildlife disease, which are the major determinants of wildlife population dynamics in human-modified landscapes. There is an urgent need to understand better the potential causal links between the processes of human-induced landscape change and the associated influences of habitat fragmentation, matrix hostility and loss of connectivity on an animal's physiological stress, immune response and disease susceptibility. This review identified no study that had assessed the influence of human-induced landscape change on the prevalence of a wildlife sexually transmitted disease. A better understanding of the various mechanisms linking human-induced landscape change and the prevalence of wildlife disease will lead to more successful conservation management outcomes. © 2012 The Authors. Biological Reviews © 2012 Cambridge Philosophical Society.

An assessment of anthropogenic and climatic stressors on estuaries using a spatio-temporal GIS-modelling approach for sustainability: Towamba estuary, southeastern Australia.

PubMed

Al-Nasrawi, Ali K M; Hamylton, Sarah M; Jones, Brian G

2018-06-03

Monitoring estuarine ecological-geomorphological dynamics has become a crucial aspect of studying the impacts of climate change and worldwide infrastructure development in coastal zones. Together, these factors have changed the natural eco-geomorphic processes that affect estuarine regimes and comprehensive modelling of coastal resources can assist managers to make appropriate decisions about their sustainable use. This study has utilised Towamba estuary (southeastern NSW, Australia), to demonstrate the value and priority of modelling estuarine dynamism as a measure of the rates and consequences of eco-geomorphic changes. This research employs several geoinformatic modelling approaches over time to investigate and assess how climate change and human activities have altered this estuarine eco-geomorphic setting. Multitemporal trend/change analysis of sediment delivery, shoreline positions and land cover, determined from fieldwork and GIS analysis of remote sensing datasets, shows significant spatio-temporal changes to the elevation and areal extent of sedimentary facies in the Towamba estuary over the past 65 years. Geomorphic growth (~ 2600 m 2 annually) has stabilised the estuarine habitats, particularly within native vegetation, salt marsh and mangrove areas. Geomorphic changes have occurred because of a combination of sediment runoff from the mostly unmodified terrestrial catchment, nearshore processes (ocean dynamics) and human activities. The construction of GIS models, verified with water and sediment samples, can characterise physical processes and quantify changes within the estuarine ecosystem. Such robust models will allow resource managers to evaluate the potential effects of changes to the current coastal ecosystems.

Psychotherapy: The Humanistic (and Effective) Treatment

ERIC Educational Resources Information Center

Wampold, Bruce E.

2007-01-01

Although it is well established that psychotherapy is remarkably effective, the change process in psychotherapy is not well understood. Psychotherapy is compared with medicine and cultural healing practices to argue that critical aspects of psychotherapy involve human processes that are used in religious, spiritual, and cultural healing practices.…

Brain reorganization, not relative brain size, primarily characterizes anthropoid brain evolution.

PubMed

Smaers, J B; Soligo, C

2013-05-22

Comparative analyses of primate brain evolution have highlighted changes in size and internal organization as key factors underlying species diversity. It remains, however, unclear (i) how much variation in mosaic brain reorganization versus variation in relative brain size contributes to explaining the structural neural diversity observed across species, (ii) which mosaic changes contribute most to explaining diversity, and (iii) what the temporal origin, rates and processes are that underlie evolutionary shifts in mosaic reorganization for individual branches of the primate tree of life. We address these questions by combining novel comparative methods that allow assessing the temporal origin, rate and process of evolutionary changes on individual branches of the tree of life, with newly available data on volumes of key brain structures (prefrontal cortex, frontal motor areas and cerebrocerebellum) for a sample of 17 species (including humans). We identify patterns of mosaic change in brain evolution that mirror brain systems previously identified by electrophysiological and anatomical tract-tracing studies in non-human primates and functional connectivity MRI studies in humans. Across more than 40 Myr of anthropoid primate evolution, mosaic changes contribute more to explaining neural diversity than changes in relative brain size, and different mosaic patterns are differentially selected for when brains increase or decrease in size. We identify lineage-specific evolutionary specializations for all branches of the tree of life covered by our sample and demonstrate deep evolutionary roots for mosaic patterns associated with motor control and learning.

Brain reorganization, not relative brain size, primarily characterizes anthropoid brain evolution

PubMed Central

Smaers, J. B.; Soligo, C.

2013-01-01

Comparative analyses of primate brain evolution have highlighted changes in size and internal organization as key factors underlying species diversity. It remains, however, unclear (i) how much variation in mosaic brain reorganization versus variation in relative brain size contributes to explaining the structural neural diversity observed across species, (ii) which mosaic changes contribute most to explaining diversity, and (iii) what the temporal origin, rates and processes are that underlie evolutionary shifts in mosaic reorganization for individual branches of the primate tree of life. We address these questions by combining novel comparative methods that allow assessing the temporal origin, rate and process of evolutionary changes on individual branches of the tree of life, with newly available data on volumes of key brain structures (prefrontal cortex, frontal motor areas and cerebrocerebellum) for a sample of 17 species (including humans). We identify patterns of mosaic change in brain evolution that mirror brain systems previously identified by electrophysiological and anatomical tract-tracing studies in non-human primates and functional connectivity MRI studies in humans. Across more than 40 Myr of anthropoid primate evolution, mosaic changes contribute more to explaining neural diversity than changes in relative brain size, and different mosaic patterns are differentially selected for when brains increase or decrease in size. We identify lineage-specific evolutionary specializations for all branches of the tree of life covered by our sample and demonstrate deep evolutionary roots for mosaic patterns associated with motor control and learning. PMID:23536600

Understanding and changing human behaviour—antibiotic mainstreaming as an approach to facilitate modification of provider and consumer behaviour

PubMed Central

Tamhankar, Ashok J.

2014-01-01

This paper addresses: 1) Situations where human behaviour is involved in relation to antibiotics, focusing on providers and consumers; 2) Theories about human behaviour and factors influencing behaviour in relation to antibiotics; 3) How behaviour in relation to antibiotics can change; and, 4) Antibiotic mainstreaming as an approach to facilitate changes in human behaviour as regards antibiotics. Influencing human behaviour in relation to antibiotics is a complex process which includes factors like knowledge, attitudes, social norms, socio-economic conditions, peer pressure, experiences, and bio-physical and socio-behavioural environment. Further, key concepts are often perceived in different ways by different individuals. While designing and implementing projects or programmes for behavioural change with respect to antibiotics for professionals or consumers it is helpful to consider theories or models of behaviour change, e.g. the ‘stages of change model’, including pre-contemplation, contemplation, preparation, action, and maintenance. People in different stages of change are susceptible to different behaviour modification strategies. Application of marketing principles to ‘global good’, so-called ‘social marketing’, to improve ‘welfare of the individual and society’ is gaining increased attention in public health. In conclusion, just providing correct knowledge is not sufficient although it is a pre-requisite for behaviour modification in the desired direction. We can never change the behaviour of any other human, but we can facilitate for others to change their own behaviour. One possibility is to implement ‘antibiotic mainstreaming’ as a potentially effective way for behaviour modification, i.e. to address consequences for maintaining effective antibiotics in all activities and decisions in society. PMID:24735112

A Study on Generic Representation of Skeletal Remains Replication of Prehistoric Burial

NASA Astrophysics Data System (ADS)

Shao, C.-W.; Chiu, H.-L.; Chang, S.-K.

2015-08-01

Generic representation of skeletal remains from burials consists of three dimensions which include physical anthropologists, replication technicians, and promotional educators. For the reason that archaeological excavation is irreversible and disruptive, detail documentation and replication technologies are surely needed for many purposes. Unearthed bones during the process of 3D digital scanning need to go through reverse procedure, 3D scanning, digital model superimposition, rapid prototyping, mould making, and the integrated errors generated from the presentation of colours and textures are important issues for the presentation of replicate skeleton remains among professional decisions conducted by physical anthropologists, subjective determination of makers, and the expectations of viewers. This study presents several cases and examines current issues on display and replication technologies for human skeletal remains of prehistoric burials. This study documented detail colour changes of human skeleton over time for the reference of reproduction. The tolerance errors of quantification and required technical qualification is acquired according to the precision of 3D scanning, the specification requirement of rapid prototyping machine, and the mould making process should following the professional requirement for physical anthropological study. Additionally, the colorimeter is adopted to record and analyse the "colour change" of the human skeletal remains from wet to dry condition. Then, the "colure change" is used to evaluate the "real" surface texture and colour presentation of human skeletal remains, and to limit the artistic presentation among the human skeletal remains reproduction. The"Lingdao man No.1", is a well preserved burial of early Neolithic period (8300 B.P.) excavated from Liangdao-Daowei site, Matsu, Taiwan , as the replicating object for this study. In this study, we examined the reproduction procedures step by step for ensuring the surface texture and colour of the replica matches the real human skeletal remains when discovered. The "colour change" of the skeleton documented and quantified in this study could be the reference for the future study and educational exhibition of human skeletal remain reproduction.

A blueprint for a Human Epigenome Project: the AACR Human Epigenome Workshop.

PubMed

Jones, Peter A; Martienssen, Robert

2005-12-15

Epigenetic processes control the packaging and function of the human genome and contribute to normal and pathologic states, including cancer. The time is ripe to undertake an international effort to identify all the chemical changes and relationships between chromatin constituents that provide function to the genetic code. A timely workshop of leading experts, convened by the American Association for Cancer Research (AACR), confirmed that the technology is at hand to begin defining human epigenomes at high resolution.

Combined global change effects on ecosystem processes in nine U.S

Treesearch

Melannie D. Hartman; Jill S. Baron; Holly A. Ewing; Kathleen C. Weathers; Chelcy Miniat

2014-01-01

Concurrent changes in climate, atmospheric nitrogen (N) deposition, and increasing levels of atmospheric carbon dioxide (CO2) affect ecosystems in complex ways. The DayCent-Chem model was used to investigate the combined effects of these human-caused drivers of change over the period 1980–2075 at seven forested montane and two alpine watersheds...

Integrated and Early Childhood Education: Preparation for Social Development. Theme D: Looking Forward - Integrated Participation in Processes of Change.

ERIC Educational Resources Information Center

Springer, Hugh

This seminar paper presents an analysis of the many complex issues inherent in planning and implementing those educational interventions designed to accelerate human change so that it matches the pace of external change in traditional societies. After establishing the importance of sensitive periods when learning can be massive and intervention is…

Direct and indirect effects of climate change on the risk of infection by water-transmitted pathogens.

PubMed

Sterk, Ankie; Schijven, Jack; de Nijs, Ton; de Roda Husman, Ana Maria

2013-11-19

Climate change is likely to affect the infectious disease burden from exposure to pathogens in water used for drinking and recreation. Effective intervention measures require quantification of impacts of climate change on the distribution of pathogens in the environment and their potential effects on human health. Objectives of this systematic review were to summarize current knowledge available to estimate how climate change may directly and indirectly affect infection risks due to Campylobacter, Cryptosporidium, norovirus, and Vibrio. Secondary objectives were to prioritize natural processes and interactions that are susceptible to climate change and to identify knowledge gaps. Search strategies were determined based on a conceptual model and scenarios with the main emphasis on The Netherlands. The literature search resulted in a large quantity of publications on climate variables affecting pathogen input and behavior in aquatic environments. However, not all processes and pathogens are evenly covered by the literature, and in many cases, the direction of change is still unclear. To make useful predictions of climate change, it is necessary to combine both negative and positive effects. This review provides an overview of the most important effects of climate change on human health and shows the importance of QMRA to quantify the net effects.

Transforming the Culture of School Leadership: Humanizing Our Practice

ERIC Educational Resources Information Center

Giancola, Joseph M.; Hutchison, Janice

2005-01-01

How do successful schools create meaningful change? How can stakeholders improve and impact final decisions in the change process? Lasting organizational improvement and effective leadership blossom in climates of compassion, trust, and productive relationships. The authors describe the key to true organizational transformation in the one-on-one…

Systems thinking for understanding and predicting regional and local climate change effects on human health & well being: workshop process

EPA Science Inventory

EPA’s Systems Thinking Advisory Team (STAT) was engaged to guide a multi-disciplinary (health officials, modelers, climate change scientists, city planners, ecologists, and architects), multi-agency (EPA, CDC, State and Country officials) team in the use systems thinking, diagram...

A Longitudinal Perspective on Inductive Reasoning Tasks. Illuminating the Probability of Change

ERIC Educational Resources Information Center

Ifenthaler, Dirk; Seel, Norbert M.

2011-01-01

Cognitive scientists have studied internal cognitive structures, processes, and systems for decades in order to understand how they function in human learning. Nevertheless, questions concerning the diagnosis of changes in these cognitive structures while solving inductive reasoning tasks are still being scrutinized. This paper reports findings…

Third Pole Environment (TPE) -Latest Progress

NASA Astrophysics Data System (ADS)

Liu, Z.; Yao, T.; Zhang, F.; Yang, X.; Wang, W.; Ping, F.

2014-12-01

Centered on the Tibetan Plateau, the Third Pole region is a unique geographical unit, which represents one of the largest ice masses on the Earth. The region has great impacts on environmental changes in China, the Northern Hemisphere and the globe.It also demonstrates sensitive feedbacks to global changes and the impacts of anthropogenic activities in surrounding regions. Like the Arctic and Antarctica, the Third Pole region is an especially sensitive area that draws great attention from the scientific community. In 2009, with support from the Chinese Academy of Sciences and international organizations, the Third Pole Environment (TPE) program, led by Chinese scientists, was officially launched. The program focuses on the theme of "water-ice-air-ecosystem-human" interactions, with the aim to address the following scientific questions, such as the spatial and temporal characteristics of past environmental changes in the Third pole, the interactions between hydrosphere and cryosphere and hazard processes, the ecological systems' impacts on and response to environmental changes, and the impacts of anthropogenic activities on environmental changes in the region and adaptation strategies. The goal of the program is to reveal environmental change processes and mechanisms on the Third Pole and their influences on and responses to global changes, and thus to serve for enhancement of human adaptation to the changing environment and realization of human-nature harmony. Under the leadership of the co-chairs, and relying on Scientific Committee and the TPE office, the program has accomplished a number of scientific tasks since its inauguration. TPE has made tremendous progress in the research of glacier changes, interactions between the westerlies and monsoon, establishment of field stations, data sharing and education.

Monkey Visual Short-Term Memory Directly Compared to Humans

PubMed Central

Elmore, L. Caitlin; Wright, Anthony A.

2015-01-01

Two adult rhesus monkeys were trained to detect which item in an array of memory items had changed using the same stimuli, viewing times, and delays as used with humans. Although the monkeys were extensively trained, they were less accurate than humans with the same array sizes (2, 4, & 6 items), with both stimulus types (colored squares, clip art), and showed calculated memory capacities of about one item (or less). Nevertheless, the memory results from both monkeys and humans for both stimulus types were well characterized by the inverse power-law of display size. This characterization provides a simple and straightforward summary of a fundamental process of visual short-term memory (how VSTM declines with memory load) that emphasizes species similarities based upon similar functional relationships. By more closely matching of monkey testing parameters to those of humans, the similar functional relationships strengthen the evidence suggesting similar processes underlying monkey and human VSTM. PMID:25706544

Uncertainty quantification and propagation in a complex human-environment system driven by fire and climate

NASA Astrophysics Data System (ADS)

Terando, A. J.; Reich, B. J.; Pacifici, K.

2013-12-01

Fire is an important disturbance process in many coupled natural-human systems. Changes in the frequency and severity of fires due to anthropogenic climate change could have significant costs to society and the plant and animal communities that are adapted to a particular fire regime Planning for these changes requires a robust model of the relationship between climate and fire that accounts for multiple sources of uncertainty that are present when simulating ecological and climatological processes. Here we model how anthropogenic climate change could affect the wildfire regime for a region in the Southeast US whose natural ecosystems are dependent on frequent, low-intensity fires while humans are at risk from large catastrophic fires. We develop a modeling framework that incorporates three major sources of uncertainty: (1) uncertainty in the ecological drivers of expected monthly area burned, (2) uncertainty in the environmental drivers influencing the probability of an extreme fire event, and (3) structural uncertainty in different downscaled climate models. In addition we use two policy-relevant emission scenarios (climate stabilization and 'business-as-usual') to characterize the uncertainty in future greenhouse gas forcings. We use a Bayesian framework to incorporate different sources of uncertainty including simulation of predictive errors and Stochastic Search Variable Selection. Our results suggest that although the mean process remains stationary, the probability of extreme fires declines through time, owing to the persistence of high atmospheric moisture content during the peak fire season that dampens the effect of increasing temperatures. Including multiple sources of uncertainty leads to wide prediction intervals, but is potentially more useful for decision-makers that will require adaptation strategies that are robust to rapid but uncertain climate and ecological change.

Preventing medical errors by designing benign failures.

PubMed

Grout, John R

2003-07-01

One way to successfully reduce medical errors is to design health care systems that are more resistant to the tendencies of human beings to err. One interdisciplinary approach entails creating design changes, mitigating human errors, and making human error irrelevant to outcomes. This approach is intended to facilitate the creation of benign failures, which have been called mistake-proofing devices and forcing functions elsewhere. USING FAULT TREES TO DESIGN FORCING FUNCTIONS: A fault tree is a graphical tool used to understand the relationships that either directly cause or contribute to the cause of a particular failure. A careful analysis of a fault tree enables the analyst to anticipate how the process will behave after the change. EXAMPLE OF AN APPLICATION: A scenario in which a patient is scalded while bathing can serve as an example of how multiple fault trees can be used to design forcing functions. The first fault tree shows the undesirable event--patient scalded while bathing. The second fault tree has a benign event--no water. Adding a scald valve changes the outcome from the undesirable event ("patient scalded while bathing") to the benign event ("no water") Analysis of fault trees does not ensure or guarantee that changes necessary to eliminate error actually occur. Most mistake-proofing is used to prevent simple errors and to create well-defended processes, but complex errors can also result. The utilization of mistake-proofing or forcing functions can be thought of as changing the logic of a process. Errors that formerly caused undesirable failures can be converted into the causes of benign failures. The use of fault trees can provide a variety of insights into the design of forcing functions that will improve patient safety.

Soil formation: Chapter 6

USGS Publications Warehouse

Goldhaber, Martin B.; Banwart, Steven A.

2015-01-01

Soil formation reflects the complex interaction of many factors, among the most important of which are (i) the nature of the soil parent material, (ii) regional climate, (iii) organisms, including humans, (iv) topography and (v) time. These processes operate in Earth's critical zone; the thin veneer of our planet where rock meets life. Understanding the operation of these soil-forming factors requires an interdisciplinary approach and is a necessary predicate to charactering soil processes and functions, mitigating soil degradation and adapting soil management to environmental change. In this chapter, we discuss how these soil-forming factors operate both singly and in concert in natural and human modified environments. We emphasize the role that soil organic matter plays in these processes to provide context for understanding the benefits that it bestows on humanity.

Individual differences in the learning potential of human beings

NASA Astrophysics Data System (ADS)

Stern, Elsbeth

2017-01-01

To the best of our knowledge, the genetic foundations that guide human brain development have not changed fundamentally during the past 50,000 years. However, because of their cognitive potential, humans have changed the world tremendously in the past centuries. They have invented technical devices, institutions that regulate cooperation and competition, and symbol systems, such as script and mathematics, that serve as reasoning tools. The exceptional learning ability of humans allows newborns to adapt to the world they are born into; however, there are tremendous individual differences in learning ability among humans that become obvious in school at the latest. Cognitive psychology has developed models of memory and information processing that attempt to explain how humans learn (general perspective), while the variation among individuals (differential perspective) has been the focus of psychometric intelligence research. Although both lines of research have been proceeding independently, they increasingly converge, as both investigate the concepts of working memory and knowledge construction. This review begins with presenting state-of-the-art research on human information processing and its potential in academic learning. Then, a brief overview of the history of psychometric intelligence research is combined with presenting recent work on the role of intelligence in modern societies and on the nature-nurture debate. Finally, promising approaches to integrating the general and differential perspective will be discussed in the conclusion of this review.

Lean processes for optimizing OR capacity utilization: prospective analysis before and after implementation of value stream mapping (VSM).

PubMed

Schwarz, Patric; Pannes, Klaus Dieter; Nathan, Michel; Reimer, Hans Jorg; Kleespies, Axel; Kuhn, Nicole; Rupp, Anne; Zügel, Nikolaus Peter

2011-10-01

The decision to optimize the processes in the operating tract was based on two factors: competition among clinics and a desire to optimize the use of available resources. The aim of the project was to improve operating room (OR) capacity utilization by reduction of change and throughput time per patient. The study was conducted at Centre Hospitalier Emil Mayrisch Clinic for specialized care (n = 618 beds) Luxembourg (South). A prospective analysis was performed before and after the implementation of optimized processes. Value stream analysis and design (value stream mapping, VSM) were used as tools. VSM depicts patient throughput and the corresponding information flows. Furthermore it is used to identify process waste (e.g. time, human resources, materials, etc.). For this purpose, change times per patient (extubation of patient 1 until intubation of patient 2) and throughput times (inward transfer until outward transfer) were measured. VSM, change and throughput times for 48 patient flows (VSM A(1), actual state = initial situation) served as the starting point. Interdisciplinary development of an optimized VSM (VSM-O) was evaluated. Prospective analysis of 42 patients (VSM-A(2)) without and 75 patients (VSM-O) with an optimized process in place were conducted. The prospective analysis resulted in a mean change time of (mean ± SEM) VSM-A(2) 1,507 ± 100 s versus VSM-O 933 ± 66 s (p < 0.001). The mean throughput time VSM-A(2) (mean ± SEM) was 151 min (±8) versus VSM-O 120 min (±10) (p < 0.05). This corresponds to a 23% decrease in waiting time per patient in total. Efficient OR capacity utilization and the optimized use of human resources allowed an additional 1820 interventions to be carried out per year without any increase in human resources. In addition, perioperative patient monitoring was increased up to 100%.

Image-plane processing of visual information

NASA Technical Reports Server (NTRS)

Huck, F. O.; Fales, C. L.; Park, S. K.; Samms, R. W.

1984-01-01

Shannon's theory of information is used to optimize the optical design of sensor-array imaging systems which use neighborhood image-plane signal processing for enhancing edges and compressing dynamic range during image formation. The resultant edge-enhancement, or band-pass-filter, response is found to be very similar to that of human vision. Comparisons of traits in human vision with results from information theory suggest that: (1) Image-plane processing, like preprocessing in human vision, can improve visual information acquisition for pattern recognition when resolving power, sensitivity, and dynamic range are constrained. Improvements include reduced sensitivity to changes in lighter levels, reduced signal dynamic range, reduced data transmission and processing, and reduced aliasing and photosensor noise degradation. (2) Information content can be an appropriate figure of merit for optimizing the optical design of imaging systems when visual information is acquired for pattern recognition. The design trade-offs involve spatial response, sensitivity, and sampling interval.

Modulators of mercury risk to wildlife and humans in the context of rapid global change

USGS Publications Warehouse

Eagles-Smith, Collin A.; Silbergeld, Ellen K.; Basu, Niladri; Bustamante, Paco; Diaz-Barriga, Fernando; Hopkins, William A.; Kidd, Karen A.; Nyland, Jennifer F.

2018-01-01

Environmental mercury (Hg) contamination is an urgent global health threat. The complexity of Hg in the environment can hinder accurate determination of ecological and human health risks, particularly within the context of the rapid global changes that are altering many ecological processes, socioeconomic patterns, and other factors like infectious disease incidence, which can affect Hg exposures and health outcomes. However, the success of global Hg-reduction efforts depends on accurate assessments of their effectiveness in reducing health risks. In this paper, we examine the role that key extrinsic and intrinsic drivers play on several aspects of Hg risk to humans and organisms in the environment. We do so within three key domains of ecological and human health risk. First, we examine how extrinsic global change drivers influence pathways of Hg bioaccumulation and biomagnification through food webs. Next, we describe how extrinsic socioeconomic drivers at a global scale, and intrinsic individual-level drivers, influence human Hg exposure. Finally, we address how the adverse health effects of Hg in humans and wildlife are modulated by a range of extrinsic and intrinsic drivers within the context of rapid global change. Incorporating components of these three domains into research and monitoring will facilitate a more holistic understanding of how ecological and societal drivers interact to influence Hg health risks.

Contributions of visual and embodied expertise to body perception.

PubMed

Reed, Catherine L; Nyberg, Andrew A; Grubb, Jefferson D

2012-01-01

Recent research has demonstrated that our perception of the human body differs from that of inanimate objects. This study investigated whether the visual perception of the human body differs from that of other animate bodies and, if so, whether that difference could be attributed to visual experience and/or embodied experience. To dissociate differential effects of these two types of expertise, inversion effects (recognition of inverted stimuli is slower and less accurate than recognition of upright stimuli) were compared for two types of bodies in postures that varied in typicality: humans in human postures (human-typical), humans in dog postures (human-atypical), dogs in dog postures (dog-typical), and dogs in human postures (dog-atypical). Inversion disrupts global configural processing. Relative changes in the size and presence of inversion effects reflect changes in visual processing. Both visual and embodiment expertise predict larger inversion effects for human over dog postures because we see humans more and we have experience producing human postures. However, our design that crosses body type and typicality leads to distinct predictions for visual and embodied experience. Visual expertise predicts an interaction between typicality and orientation: greater inversion effects should be found for typical over atypical postures regardless of body type. Alternatively, embodiment expertise predicts a body, typicality, and orientation interaction: larger inversion effects should be found for all human postures but only for atypical dog postures because humans can map their bodily experience onto these postures. Accuracy data supported embodiment expertise with the three-way interaction. However, response-time data supported contributions of visual expertise with larger inversion effects for typical over atypical postures. Thus, both types of expertise affect the visual perception of bodies.

Chew Bahir, southern Ethiopia: an archive of environmental history during the evolution and dispersal of anatomically modern humans

NASA Astrophysics Data System (ADS)

Schaebitz, F.; Asrat, A.; Lamb, H. F.; Trauth, M. H.; Junginger, A.; Foerster, V. E.; Guenter, C.; Viehberg, F. A.; Just, J.; Roberts, H. M.; Chapot, M. S.; Leng, M. J.; Dean, J.; Cohen, A. S.

2016-12-01

Chew Bahir is a tectonic basin in the southern Ethiopian Rift, close to the Lower Omo valley, site of earliest known fossil of anatomically modern humans. It was drilled in Nov-Dec 2014 as part of the Hominin Sites and Paleolakes Drilling Project (HSPDP) and the Collaborative Research Center (CRC806) "Our Way to Europe". Two overlapping cores of mostly clayey silts, reaching a composite depths of 280m, were collected and may cover the last 500,000 years, thus providing a potential record of environmental history during the evolution and spread of anatomically modern humans. Here we present the lithology and stratigraphy of the composite core as well as results of high resolution MSCL and XRF scanning data. Initial sedimentological and geochemical results show that the Chew Bahir deposits are a sensitive record of changes in moisture, sediment influx, provenance, transport and diagenetic processes, evident from mineralogy, elemental concentration and physical properties. The potassium record is highly sensitive to changes in moisture balance (Foerster et al. 2015). XRF and XRD data suggest that the process linking climate with potassium concentrations is the diagenetic illitization of smectites during dry episodes with high alkalinity and salinity in the closed-basin lake. The core records will allow tests of the various hypotheses about the influence of environmental change on the evolution and dispersal of anatomically modern humans. Foerster, V., Vogelsang, R., Junginger, A., Asrat, A., Lamb, H.F., Schaebitz, F., Trauth, M.H. (2015): Environmental Change and Human Occupation of Southern Ethiopia and Northern Kenya during the last 20,000 years. Quaternary Science Reviews, 129: 333-340. doi:10.1016/j.quascirev.2015.10.026.

Economic Liberalization and Its Impact on Human Development: A Comparative Analysis of Turkey and Azerbaijan

ERIC Educational Resources Information Center

Gulaliyev, Mayis G.; Ok, Nuri I.; Musayeva, Fargana Q.; Efendiyev, Rufat J.; Musayeva, Jamila Q.; Agayeva, Samira R.

2016-01-01

The aim of the article is to study the nature of liberalization as a specific economic process, which is formed and developed under the influence of the changing conditions of the globalization and integration processes in the society, as well as to identify the characteristic differences in the processes of liberalization of Turkey and Azerbaijan…

Emotions, the Great Captains of Our Lives: Their Role in the Process of Change in Psychotherapy

ERIC Educational Resources Information Center

Greenberg, Leslie S.

2012-01-01

A view of human functioning is presented in which functioning is seen as integrating head and heart, emotion and reason, in a process by which people are constantly making sense of their lived emotional experience to form narratives of told experience. Because much of the processing involved in the generation of emotional experience occurs…

Smart Camera Technology Increases Quality

NASA Technical Reports Server (NTRS)

2004-01-01

When it comes to real-time image processing, everyone is an expert. People begin processing images at birth and rapidly learn to control their responses through the real-time processing of the human visual system. The human eye captures an enormous amount of information in the form of light images. In order to keep the brain from becoming overloaded with all the data, portions of an image are processed at a higher resolution than others, such as a traffic light changing colors. changing colors. In the same manner, image processing products strive to extract the information stored in light in the most efficient way possible. Digital cameras available today capture millions of pixels worth of information from incident light. However, at frame rates more than a few per second, existing digital interfaces are overwhelmed. All the user can do is store several frames to memory until that memory is full and then subsequent information is lost. New technology pairs existing digital interface technology with an off-the-shelf complementary metal oxide semiconductor (CMOS) imager to provide more than 500 frames per second of specialty image processing. The result is a cost-effective detection system unlike any other.

Using conceptual maps to assess students' climate change understanding and misconceptions

NASA Astrophysics Data System (ADS)

Gautier, C.

2011-12-01

The complex and interdisciplinary nature of climate change science poses special challenges for educators in helping students understand the climate system, and how it is evolving under natural and anthropogenic forcing. Students and citizens alike have existing mental models that may limit their perception and processing of the multiple relationships between processes (e.g., feedback) that arise in global change science, and prevent adoption of complex scientific concepts. Their prior knowledge base serves as the scaffold for all future learning and grasping its range and limitations serves as an important basis upon which to anchor instruction. Different instructional strategies can be adopted to help students understand the inherently interdisciplinary topic of global climate change, its interwoven human and natural causes, and the connections it has with society through a complex range of political, social, technological and economic factors. One assessment method for students' understanding of global climate change with its many uncertainties, whether associated with the workings of the climate system or with respect to social, cultural and economic processes that mediate human responses to changes within the system, is through the use of conceptual maps. When well designed, they offer a representation of students' mental model prior and post instruction. We will present two conceptual mapping activities used in the classroom to assess students' knowledge and understanding about global climate change and uncover misconceptions. For the first one, concept maps will be used to demonstrate evidence of learning and conceptual change, while for the second we will show how conceptual maps can provide information about gaps in knowledge and misconceptions students have about the topic.

Variations in Urine Calcium Isotope: Composition Reflect Changes in Bone Mineral Balance in Humans

NASA Technical Reports Server (NTRS)

Skulan, Joseph; Anbar, Ariel; Bullen, Thomas; Puzas, J. Edward; Shackelford, Linda; Smith, Scott M.

2004-01-01

Changes in bone mineral balance cause rapid and systematic changes in the calcium isotope composition of human urine. Urine from subjects in a 17 week bed rest study was analyzed for calcium isotopic composition. Comparison of isotopic data with measurements of bone mineral density and metabolic markers of bone metabolism indicates the calcium isotope composition of urine reflects changes in bone mineral balance. Urine calcium isotope composition probably is affected by both bone metabolism and renal processes. Calcium isotope. analysis of urine and other tissues may provide information on bone mineral balance that is in important respects better than that available from other techniques, and illustrates the usefulness of applying geochemical techniques to biomedical problems.

Animal taxa contrast in their scale-dependent responses to land use change in rural Africa.

PubMed

Foord, Stefan Hendrik; Swanepoel, Lourens Hendrik; Evans, Steven William; Schoeman, Colin Stefan; Erasmus, Barend Frederik N; Schoeman, M Corrie; Keith, Mark; Smith, Alain; Mauda, Evans Vusani; Maree, Naudene; Nembudani, Nkhumeleni; Dippenaar-Schoeman, Anna Sophia; Munyai, Thinandavha Caswell; Taylor, Peter John

2018-01-01

Human-dominated landscapes comprise the bulk of the world's terrestrial surface and Africa is predicted to experience the largest relative increase over the next century. A multi-scale approach is required to identify processes that maintain diversity in these landscapes. Here we identify scales at which animal diversity responds by partitioning regional diversity in a rural African agro-ecosystem between one temporal and four spatial scales. Human land use practices are the main driver of diversity in all seven animal assemblages considered, with medium sized mammals and birds most affected. Even the least affected taxa, bats and non-volant small mammals (rodents), responded with increased abundance in settlements and agricultural sites respectively. Regional turnover was important to invertebrate taxa and their response to human land use was intermediate between that of the vertebrate extremes. Local scale (< 300 m) heterogeneity was the next most important level for all taxa, highlighting the importance of fine scale processes for the maintenance of biodiversity. Identifying the triggers of these changes within the context of functional landscapes would provide the context for the long-term sustainability of these rapidly changing landscapes.

Specialization in the Human Brain: The Case of Numbers

PubMed Central

Kadosh, Roi Cohen; Bahrami, Bahador; Walsh, Vincent; Butterworth, Brian; Popescu, Tudor; Price, Cathy J.

2011-01-01

How numerical representation is encoded in the adult human brain is important for a basic understanding of human brain organization, its typical and atypical development, its evolutionary precursors, cognitive architectures, education, and rehabilitation. Previous studies have shown that numerical processing activates the same intraparietal regions irrespective of the presentation format (e.g., symbolic digits or non-symbolic dot arrays). This has led to claims that there is a single format-independent, numerical representation. In the current study we used a functional magnetic resonance adaptation paradigm, and effective connectivity analysis to re-examine whether numerical processing in the intraparietal sulci is dependent or independent on the format of the stimuli. We obtained two novel results. First, the whole brain analysis revealed that format change (e.g., from dots to digits), in the absence of a change in magnitude, activated the same intraparietal regions as magnitude change, but to a greater degree. Second, using dynamic causal modeling as a tool to disentangle neuronal specialization across regions that are commonly activated, we found that the connectivity between the left and right intraparietal sulci is format-dependent. Together, this line of results supports the idea that numerical representation is subserved by multiple mechanisms within the same parietal regions. PMID:21808615

Animal taxa contrast in their scale-dependent responses to land use change in rural Africa

PubMed Central

Swanepoel, Lourens Hendrik; Evans, Steven William; Schoeman, Colin Stefan; Erasmus, Barend Frederik N.; Schoeman, M. Corrie; Keith, Mark; Smith, Alain; Mauda, Evans Vusani; Maree, Naudene; Nembudani, Nkhumeleni; Dippenaar-Schoeman, Anna Sophia; Munyai, Thinandavha Caswell; Taylor, Peter John

2018-01-01

Human-dominated landscapes comprise the bulk of the world’s terrestrial surface and Africa is predicted to experience the largest relative increase over the next century. A multi-scale approach is required to identify processes that maintain diversity in these landscapes. Here we identify scales at which animal diversity responds by partitioning regional diversity in a rural African agro-ecosystem between one temporal and four spatial scales. Human land use practices are the main driver of diversity in all seven animal assemblages considered, with medium sized mammals and birds most affected. Even the least affected taxa, bats and non-volant small mammals (rodents), responded with increased abundance in settlements and agricultural sites respectively. Regional turnover was important to invertebrate taxa and their response to human land use was intermediate between that of the vertebrate extremes. Local scale (< 300 m) heterogeneity was the next most important level for all taxa, highlighting the importance of fine scale processes for the maintenance of biodiversity. Identifying the triggers of these changes within the context of functional landscapes would provide the context for the long-term sustainability of these rapidly changing landscapes. PMID:29738559

Evaluating Decoupling Process in OECD Countries: Case Study of Turkey

NASA Astrophysics Data System (ADS)

An, Nazan; Şengün Ucal, Meltem; Kurnaz, M. Levent

2017-04-01

Climate change is at the top of the present and future problems facing humanity. Climate change is now largely attributed to human activities and economic activities are the source of human activities that cause climate change by creating pressure on the environment. Providing the sustainability of resources for the future seems possible by reducing the pressure of these economic activities on the environment. Given the increasing population pressure and growth-focused economies, it is possible to say that achieving decoupling is not so easy on a global basis. It is known that there are some problems in developing countries especially in terms of accessing reliable data in transition and implementation process of decoupling. Developed countries' decoupling practices and proper calculation methods can also be a guide for developing countries. In this study, we tried to calculate the comparative decoupling index for OECD countries and Turkey in terms of data suitability, and we showed the differences between them. We tried to indicate the level of decoupling (weak, stable, strong) for each country. We think that the comparison of Turkey can be an example in terms of developing countries. Acknowledgement: This research has been supported by Bogazici University Research Fund Grant Number 12220.

[Effects of infrasound therapy on proliferation, apoptosis and ultrastructure of human B lymphoma Raji cells].

PubMed

Bao, Yong; Fan, Jian-Zhong; Li, Ke; Li, Chuan; Yang, Jun-Feng

2008-06-01

To investigate the effect of infrasound therapy on the proliferation, apoptosis and ultrastructure of human B lymphoma Raji cells. Human B lymphoma Raji cells were exposed to infrasound treatment for 15, 30, 60, 90 and 120 min and cultured subsequently for 24 or 48 h. MTT assay, flow cytometry analysis, and electron microscopy were performed to examine the proliferative status, cell apoptosis and ultrastructural changes of the exposed cells, respectively. MTT assay revealed no significant changes in the proliferation of the cells exposed to infrasound treatment (P>0.05), nor did flow cytometry analysis identified significant variation in the cell apoptosis (P>0.05). Scanning electron microscopy, however, identified shortened or reduced cell processes and microvilli on the surface of the cells with infrasound exposure and a subsequent 24-hour culture, and the cell membrane surface became smooth. Under transmission electron microscope, the cells with infrasound treatment presented with significantly reduced microvilli, and the cell nuclei appeared homogeneous, with cytoplasmic budding and losses after a 48-hour culture. Infrasound less than 90 dB does not obviously affect the proliferation and apoptosis of Raji cells, but may directly cause cell ultrastructural changes such as reduction of the cell processes.

A Network Neuroscience of Human Learning: Potential To Inform Quantitative Theories of Brain and Behavior

PubMed Central

Bassett, Danielle S.; Mattar, Marcelo G.

2017-01-01

Humans adapt their behavior to their external environment in a process often facilitated by learning. Efforts to describe learning empirically can be complemented by quantitative theories that map changes in neurophysiology to changes in behavior. In this review we highlight recent advances in network science that offer a sets of tools and a general perspective that may be particularly useful in understanding types of learning that are supported by distributed neural circuits. We describe recent applications of these tools to neuroimaging data that provide unique insights into adaptive neural processes, the attainment of knowledge, and the acquisition of new skills, forming a network neuroscience of human learning. While promising, the tools have yet to be linked to the well-formulated models of behavior that are commonly utilized in cognitive psychology. We argue that continued progress will require the explicit marriage of network approaches to neuroimaging data and quantitative models of behavior. PMID:28259554

A Network Neuroscience of Human Learning: Potential to Inform Quantitative Theories of Brain and Behavior.

PubMed

Bassett, Danielle S; Mattar, Marcelo G

2017-04-01

Humans adapt their behavior to their external environment in a process often facilitated by learning. Efforts to describe learning empirically can be complemented by quantitative theories that map changes in neurophysiology to changes in behavior. In this review we highlight recent advances in network science that offer a sets of tools and a general perspective that may be particularly useful in understanding types of learning that are supported by distributed neural circuits. We describe recent applications of these tools to neuroimaging data that provide unique insights into adaptive neural processes, the attainment of knowledge, and the acquisition of new skills, forming a network neuroscience of human learning. While promising, the tools have yet to be linked to the well-formulated models of behavior that are commonly utilized in cognitive psychology. We argue that continued progress will require the explicit marriage of network approaches to neuroimaging data and quantitative models of behavior. Copyright © 2017 Elsevier Ltd. All rights reserved.

Towards a new paradigm of Socio-Hydrology; insights from the Saskatchewan River Basin

NASA Astrophysics Data System (ADS)

Wheater, H. S.; Gober, P.

2011-12-01

Effects of human-induced change on the land surface and the functioning of water systems are ubiquitous. There is a basic need to understand these human processes and to represent them appropriately in hydrological models. Some land use effects, such as urbanisation, are well understood, but not readily quantifiable at catchment scale. Agricultural intensification, on the other hand, is poorly understood, and tools for quantification often lack scientific basis. And while land surface change affects runoff and recharge, in most major river systems flows are also modified by storage, withdrawals and returns; groundwater is also often heavily influenced by management. Quantification of these effects remains a major and neglected challenge - much large-scale hydrological modelling is concerned with hypothetical 'natural' systems. At a deeper level, in an era of rapid change and profound uncertainties about both human and physical systems, water management requires an understanding of the drivers of, and responses to change. Socio-hydrology has two very specific social components: 1. Integrating humans and their activities into water science. 2. Ensuring that water decision-making incorporates a range of values and perspectives about the meaning, value and use of water. Socio-hydrology recognizes that many of the current stresses on water systems stem from social factors such as demography, the global economy, changing societal values and norms, technological innovation, laws and customs, and financial markets. It also acknowledges that the inability of many water systems to adjust to change is because of outdated governance, institutional rigidity, failure to adequately perceive threats to water security, ill-functioning markets, and undue focus on physical at the expense of social change. Increasingly, it is recognized that some of the most critical vulnerabilities in contemporary water systems lie at the intersection between human activities and physical systems, such as when governance systems are incapable of dealing with climate-induced changes in water supply. Socio-hydrology also incorporates research into the processes by translating traditional scientific information into tools for water decision making. These processes are inherently social and value-based. They depend upon the way various water stakeholders (e.g. municipalities, farmers, mining companies, environmental groups, Aboriginal Peoples) define the problem of water security and the values they place on different aspects of it. Socio-hydrology is at the forefront of efforts to establish and study participatory processes for decision making in the water sector. We illustrate these issues by reference to the inter-provincial Saskatchewan River Basin in western Canada. The University of Saskatchewan has established socio-hydrology as a priority research area. Our goal is to integrate hydro-ecological research with social science to study societal responses to water stresses like flooding, drought and nutrient pollution and investigate the potential of existing and new economic and other policy instruments to help communities make sound decisions under uncertainty.

Online mentalising investigated with functional MRI.

PubMed

Kircher, Tilo; Blümel, Isabelle; Marjoram, Dominic; Lataster, Tineke; Krabbendam, Lydia; Weber, Jochen; van Os, Jim; Krach, Sören

2009-05-01

For successful interpersonal communication, inferring intentions, goals or desires of others is highly advantageous. Increasingly, humans also interact with computers or robots. In this study, we sought to determine to what degree an interactive task, which involves receiving feedback from social partners that can be used to infer intent, engaged the medial prefrontal cortex, a region previously associated with Theory of Mind processes among others. Participants were scanned using fMRI as they played an adapted version of the Prisoner's Dilemma Game with alleged human and computer partners who were outside the scanner. The medial frontal cortex was activated when both human and computer partner were played, while the direct contrast revealed significantly stronger signal change during the human-human interaction. The results suggest a link between activity in the medial prefrontal cortex and the partner played in a mentalising task. This signal change was also present for to the computers partner. Implying agency or a will to non-human actors might be an innate human resource that could lead to an evolutionary advantage.

Modeling large-scale human alteration of land surface hydrology and climate

NASA Astrophysics Data System (ADS)

Pokhrel, Yadu N.; Felfelani, Farshid; Shin, Sanghoon; Yamada, Tomohito J.; Satoh, Yusuke

2017-12-01

Rapidly expanding human activities have profoundly affected various biophysical and biogeochemical processes of the Earth system over a broad range of scales, and freshwater systems are now amongst the most extensively altered ecosystems. In this study, we examine the human-induced changes in land surface water and energy balances and the associated climate impacts using a coupled hydrological-climate model framework which also simulates the impacts of human activities on the water cycle. We present three sets of analyses using the results from two model versions—one with and the other without considering human activities; both versions are run in offline and coupled mode resulting in a series of four experiments in total. First, we examine climate and human-induced changes in regional water balance focusing on the widely debated issue of the desiccation of the Aral Sea in central Asia. Then, we discuss the changes in surface temperature as a result of changes in land surface energy balance due to irrigation over global and regional scales. Finally, we examine the global and regional climate impacts of increased atmospheric water vapor content due to irrigation. Results indicate that the direct anthropogenic alteration of river flow in the Aral Sea basin resulted in the loss of 510 km3 of water during the latter half of the twentieth century which explains about half of the total loss of water from the sea. Results of irrigation-induced changes in surface energy balance suggest a significant surface cooling of up to 3.3 K over 1° grids in highly irrigated areas but a negligible change in land surface temperature when averaged over sufficiently large global regions. Results from the coupled model indicate a substantial change in 2 m air temperature and outgoing longwave radiation due to irrigation, highlighting the non-local (regional and global) implications of irrigation. These results provide important insights on the direct human alteration of land surface water and energy balances, highlighting the need to incorporate human activities such as irrigation into the framework of global climate models and Earth system models for better prediction of future changes under increasing human influence and continuing global climate change.

Consequences of residential development for biodiversity and human well-being

Treesearch

Liba Pejchar; Sarah E. Reed; Patrick Bixler; Lindsay Ex; Miranda H. Mockrin

2015-01-01

Residential development is a leading driver of land-use change, with important implications for biodiversity, ecosystem processes, and human well-being. We reviewed over 500 published scientific articles on the biophysical, economic, and social effects of residential development and open space in the US. We concluded that current knowledge of the effects of this type...

The Human Cost of Producing Human Capital

ERIC Educational Resources Information Center

Zaiser, Richard

2017-01-01

In Austria the process of business-oriented educational reforms started 15 years ago but it is only now, after the implementation of the new school-leaving exams in the 2014-15 school year, that everybody has become aware of the profound changes made in the educational system. Despite the long-lasting debates and arguments, and the visible…

Predator Force Structure Changes at Indian Springs Air Force Auxiliary Field, Nevada Environmental Assessment

DTIC Science & Technology

2003-07-01

Office Agency for Nuclear Projects Energy Agriculture Business & Industry Minerals Economic Development Tourism Fire Marshal Human Resources...Agriculture Business & Industry Minerals Economic Development Tourism Fire Marshal Human Resources A in Services Indian Commission Colorado...Data EIAP Environmental Impact Analysis Process EMCS Central Energy Management System ERP Environmental Restoration Program ESA Endangered

Life Is Getting Better: Societal Evolution and Fit with Human Nature

ERIC Educational Resources Information Center

Veenhoven, Ruut

2010-01-01

Human society has changed much over the last centuries and this process of "modernization" has profoundly affected the lives of individuals; currently we live quite different lives from those forefathers lived only five generations ago. There is difference of opinion as to whether we live better now than before and consequently there is also…

Capturing Moment-To-Moment Changes in Multivariate Human Experience

ERIC Educational Resources Information Center

De Ruiter, Naomi M. P.; Van Der Steen, Steffie; Den Hartigh, Ruud J. R.; Van Geert, Paul L. C.

2017-01-01

In this article, we aim to shed light on a technique to study intra-individual variability that spans the time frame of seconds and minutes, i.e., micro-level development. This form of variability is omnipresent in behavioural development and processes of human experience, yet is often ignored in empirical studies, given a lack of proper analysis…

Building Futurism into the Institution's Strategic Planning and Human Resource Development Model.

ERIC Educational Resources Information Center

Groff, Warren H.

A process for building futurism into the institution's strategic planning and human resource development model is described. It is an attempt to assist faculty and staff to understand the future and the formulation and revision of professional goals in relation to an image of the future. A conceptual framework about the changing nature of human…

Degradation of soils as a result of human-induced transformation of their water regime and soil-protective practice

NASA Astrophysics Data System (ADS)

Zaidel'Man, F. R.

2009-01-01

The adverse human-induced changes in the water regime of soils leading to their degradation are considered. Factors of the human activity related to the water industry, agriculture, and silviculture are shown to play the most active role in the soil degradation. Among them are the large-scale hydraulic works on rivers, drainage and irrigation of soils, ameliorative and agricultural impacts, road construction, and uncontrolled impacts of industry and silviculture on the environment. The reasons for each case of soil degradation related to changes in the soil water regime are considered, and preventive measures are proposed. The role of secondary soil degradation processes is shown.

About possibility of temperature trace observing on a human skin through clothes by using computer processing of IR image

NASA Astrophysics Data System (ADS)

Trofimov, Vyacheslav A.; Trofimov, Vladislav V.; Shestakov, Ivan L.; Blednov, Roman G.

2017-05-01

One of urgent security problems is a detection of objects placed inside the human body. Obviously, for safety reasons one cannot use X-rays for such object detection widely and often. For this purpose, we propose to use THz camera and IR camera. Below we continue a possibility of IR camera using for a detection of temperature trace on a human body. In contrast to passive THz camera using, the IR camera does not allow to see very pronounced the object under clothing. Of course, this is a big disadvantage for a security problem solution based on the IR camera using. To find possible ways for this disadvantage overcoming we make some experiments with IR camera, produced by FLIR Company and develop novel approach for computer processing of images captured by IR camera. It allows us to increase a temperature resolution of IR camera as well as human year effective susceptibility enhancing. As a consequence of this, a possibility for seeing of a human body temperature changing through clothing appears. We analyze IR images of a person, which drinks water and eats chocolate. We follow a temperature trace on human body skin, caused by changing of temperature inside the human body. Some experiments are made with observing of temperature trace from objects placed behind think overall. Demonstrated results are very important for the detection of forbidden objects, concealed inside the human body, by using non-destructive control without using X-rays.

Physiological studies of the brain: Implications for science teaching

NASA Astrophysics Data System (ADS)

Esler, William K.

Physiological changes resulting from repeated, long-term stimulation have been observed in the brains of both humans and laboratory animals. It may be speculated that these changes are related to short-term and long-term memory processes. A physiologically based model for memory processing (PBMMP) can serve to explain the interrelations of various areas of the brain as they process new stimuli and recall past events. The model can also serve to explain many current principles of learning theory and serve as a foundation for developing new theories of learning based upon the physiology of the brain.

Sister grouping of chimpanzees and humans as revealed by genome-wide phylogenetic analysis of brain gene expression profiles

PubMed Central

Uddin, Monica; Wildman, Derek E.; Liu, Guozhen; Xu, Wenbo; Johnson, Robert M.; Hof, Patrick R.; Kapatos, Gregory; Grossman, Lawrence I.; Goodman, Morris

2004-01-01

Gene expression profiles from the anterior cingulate cortex (ACC) of human, chimpanzee, gorilla, and macaque samples provide clues about genetic regulatory changes in human and other catarrhine primate brains. The ACC, a cerebral neocortical region, has human-specific histological features. Physiologically, an individual's ACC displays increased activity during that individual's performance of cognitive tasks. Of ≈45,000 probe sets on microarray chips representing transcripts of all or most human genes, ≈16,000 were commonly detected in human ACC samples and comparable numbers, 14,000–15,000, in gorilla and chimpanzee ACC samples. Phylogenetic results obtained from gene expression profiles contradict the traditional expectation that the non-human African apes (i.e., chimpanzee and gorilla) should be more like each other than either should be like humans. Instead, the chimpanzee ACC profiles are more like the human than like the gorilla; these profiles demonstrate that chimpanzees are the sister group of humans. Moreover, for those unambiguous expression changes mapping to important biological processes and molecular functions that statistically are significantly represented in the data, the chimpanzee clade shows at least as much apparent regulatory evolution as does the human clade. Among important changes in the ancestry of both humans and chimpanzees, but to a greater extent in humans, are the up-regulated expression profiles of aerobic energy metabolism genes and neuronal function-related genes, suggesting that increased neuronal activity required increased supplies of energy. PMID:14976249

Using critical evaluation to reappraise plausibility judgments: A critical cognitive component of conceptual change

NASA Astrophysics Data System (ADS)

Lombardi, D.

2011-12-01

Plausibility judgments-although well represented in conceptual change theories (see, for example, Chi, 2005; diSessa, 1993; Dole & Sinatra, 1998; Posner et al., 1982)-have received little empirical attention until our recent work investigating teachers' and students' understanding of and perceptions about human-induced climate change (Lombardi & Sinatra, 2010, 2011). In our first study with undergraduate students, we found that greater plausibility perceptions of human-induced climate accounted for significantly greater understanding of weather and climate distinctions after instruction, even after accounting for students' prior knowledge (Lombardi & Sinatra, 2010). In a follow-up study with inservice science and preservice elementary teachers, we showed that anger about the topic of climate change and teaching about climate change was significantly related to implausible perceptions about human-induced climate change (Lombardi & Sinatra, 2011). Results from our recent studies helped to inform our development of a model of the role of plausibility judgments in conceptual change situations. The model applies to situations involving cognitive dissonance, where background knowledge conflicts with an incoming message. In such situations, we define plausibility as a judgment on the relative potential truthfulness of incoming information compared to one's existing mental representations (Rescher, 1976). Students may not consciously think when making plausibility judgments, expending only minimal mental effort in what is referred to as an automatic cognitive process (Stanovich, 2009). However, well-designed instruction could facilitate students' reappraisal of plausibility judgments in more effortful and conscious cognitive processing. Critical evaluation specifically may be one effective method to promote plausibility reappraisal in a classroom setting (Lombardi & Sinatra, in progress). In science education, critical evaluation involves the analysis of how evidentiary data support a hypothesis and its alternatives. The presentation will focus on how instruction promoting critical evaluation can encourage individuals to reappraise their plausibility judgments and initiate knowledge reconstruction. In a recent pilot study, teachers experienced an instructional scaffold promoting critical evaluation of two competing climate change theories (i.e., human-induced and increasing solar irradiance) and significantly changed both their plausibility judgments and perceptions of correctness toward the scientifically-accepted model of human-induced climate change. A comparison group of teachers who did not experience the critical evaluation activity showed no significant change. The implications of these studies for future research and instruction will be discussed in the presentation, including effective ways to increase students' and teachers' ability to be critically evaluative and reappraise their plausibility judgments. With controversial science issues, such as climate change, such abilities may be necessary to facilitate conceptual change.

Total Quality Management: Getting Started

DTIC Science & Technology

1990-08-01

Quality Management (TQM) program using Organizational Development (OD) intervention techniques to gain acceptance of the program. It emphasizes human behavior and the need for collaborative management and consensus in organizational change. Lessons learned stress the importance of choosing a skilled TQM facilitator, training process action teams, and fostering open communication and teamwork to minimize resistance to change. Keywords: Management planning and control, Quality control, Quality , Management , Organization change, Organization development,

Climate and land use controls over terrestrial water use efficiency in monsoon Asia.

Treesearch

Hanqin Tian; Chaoqun Lu; Guangsheng Chen; Xiaofeng Xu; Mingliang Liu; et al

2011-01-01

Much concern has been raised regarding how and to what extent climate change and intensive human activities have altered water use efficiency (WUE, amount of carbon uptake per unit of water use) in monsoon Asia. By using a process-based ecosystem model [dynamic land ecosystem model (DLEM)], we examined effects of climate change, land use/cover change, and land...

An Objective Method of Measuring Psychological States Associated With Changes in Neural Function: Content Analysis of Verbal Behavior.

ERIC Educational Resources Information Center

Gottschalk, Louis A.

This paper examines the use of content analysis of speech in the objective recording and measurement of changes in emotional and cognitive function of humans in whom natural or experimental changes in neural status have occurred. A brief description of the data gathering process, details of numerous physiological effects, an anxiety scale, and a…

Compounding Impacts of Human-Induced Water Stress and Climate Change on Water Availability

DOE PAGES

Mehran, Ali; AghaKouchak, Amir; Nakhjiri, Navid; ...

2017-07-24

The terrestrial phase of the water cycle can be seriously impacted by water management and human water use behavior (e.g., reservoir operation, and irrigation withdrawals). Here we outline a method for assessing water availability in a changing climate, while explicitly considering anthropogenic water demand scenarios and water supply infrastructure designed to cope with climatic extremes. The framework brings a top-down and bottom-up approach to provide localized water assessment based on local water supply infrastructure and projected water demands. When our framework is applied to southeastern Australia we find that, for some combinations of climatic change and water demand, the regionmore » could experience water stress similar or worse than the epic Millennium Drought. We show considering only the influence of future climate on water supply, and neglecting future changes in water demand and water storage augmentation might lead to opposing perspectives on future water availability. While human water use can significantly exacerbate climate change impacts on water availability, if managed well, it allows societies to react and adapt to a changing climate. The methodology we present offers a unique avenue for linking climatic and hydrologic processes to water resource supply and demand management and other human interactions.« less

Compounding Impacts of Human-Induced Water Stress and Climate Change on Water Availability

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mehran, Ali; AghaKouchak, Amir; Nakhjiri, Navid

The terrestrial phase of the water cycle can be seriously impacted by water management and human water use behavior (e.g., reservoir operation, and irrigation withdrawals). Here we outline a method for assessing water availability in a changing climate, while explicitly considering anthropogenic water demand scenarios and water supply infrastructure designed to cope with climatic extremes. The framework brings a top-down and bottom-up approach to provide localized water assessment based on local water supply infrastructure and projected water demands. When our framework is applied to southeastern Australia we find that, for some combinations of climatic change and water demand, the regionmore » could experience water stress similar or worse than the epic Millennium Drought. We show considering only the influence of future climate on water supply, and neglecting future changes in water demand and water storage augmentation might lead to opposing perspectives on future water availability. While human water use can significantly exacerbate climate change impacts on water availability, if managed well, it allows societies to react and adapt to a changing climate. The methodology we present offers a unique avenue for linking climatic and hydrologic processes to water resource supply and demand management and other human interactions.« less

GEO-MOTION: A fresh approach to land, water and sea level changes in a European habitat

NASA Astrophysics Data System (ADS)

Cloetingh, S.; Geo-Motion Consortium, T.; GEO-MOTION Consortium

2003-04-01

The present state and behaviour of the Shallow Earth System is a consequence of processes on a wide range of time scales. These include the long term tectonic effects on uplift, subsidence and river systems, residual effects of the ice ages on crustal movement and geochemistry, natural climate to environmental changes over recent millennia and up to the present, and the powerful anthropogenic impacts of the last century. If we are to understand the present state of the system, to predict its future and to engineer our use of it, this spectrum of processes, operating concurrently but on different time scales, needs to be better understood. The challenge to the Geosciences is to describe the state of the system, to monitor its changes, to forecast its evolution and, in collaboration with others, to evaluate modes of sustainable use by human society. Land, water and sea level changes can seriously affect the sustainability of ecological and human habitats in Europe. When sea water or surface water levels rise, or land subsides, the risk of flooding increases, directly inflicting on local ecosystems and human habitats. The effects on society are widely known as many of the affected areas in Europe are densely populated and the financial loss foreseen is tremendous. On the other hand, declining water levels and uplift may lead to a higher risk of desertification. These changes are caused by both natural processes and human activities, but the absolute and relative contributions of each of these processes are still little understood. Only very recently, the impact of processes located in the underlying subsurface of intraplate areas has been recognized in the coastal realm, leading to the newly coined term ‘Environmental Earth System Dynamics’. The members of the Geo-Motion consortium have joined forces in order to create a fully integrated pan-European research infrastructure (a virtual scientific centre) on a hitherto not existing scale. It runs monitoring programs including satellite, surface and borehole monitoring instruments. It integrates large scale and excellent geo-mechanical, geo-chemical and geo-biological laboratory facilities. Based on existing structures and data sets it develops a new geo data infrastructure containing historical data on global and regional changes in combination with the vulnerability of natural and human habitats. Most significant milestones are a large scale and excellent know-how base on geo-motion modelling and simulation, as well as on risk and impact assessment. The development of a foresight and assessment competency represents a long-term strategic scientific objective for the consortium. It is vital that it is also promoted in education, which will be done through the development of a European School for Predictive Geoscience, in which parallel masters programmes will be offered by the university partners based on their pooled expertise. The national geoscience surveys play a key role in delivering the outputs of research into the public, policy and industrial domains.

DHM simulation in virtual environments: a case-study on control room design.

PubMed

Zamberlan, M; Santos, V; Streit, P; Oliveira, J; Cury, R; Negri, T; Pastura, F; Guimarães, C; Cid, G

2012-01-01

This paper will present the workflow developed for the application of serious games in the design of complex cooperative work settings. The project was based on ergonomic studies and development of a control room among participative design process. Our main concerns were the 3D human virtual representation acquired from 3D scanning, human interaction, workspace layout and equipment designed considering ergonomics standards. Using Unity3D platform to design the virtual environment, the virtual human model can be controlled by users on dynamic scenario in order to evaluate the new work settings and simulate work activities. The results obtained showed that this virtual technology can drastically change the design process by improving the level of interaction between final users and, managers and human factors team.

Climate change reduces the net sink of CH4 and N2O in a semiarid grassland

USDA-ARS?s Scientific Manuscript database

Methane (CH4) and nitrous oxide (N2O) are potent greenhouse gases; their concentrations in the atmosphere have increased because of human activity. Soils are important sources and sinks of both gases where their production and consumption are largely regulated by biological processes. Climate change...

Life and Work in a Technological Society. ERIC Digest No. 147.

ERIC Educational Resources Information Center

Kerka, Sandra

Technology is more than applied science. It is the processes and products by which humans have coped with and changed their environment throughout history. People have always lived and worked in a "technological society." Never before, however, has technological change been so rapid or broad in scope. The concept of an "educated…

Teaching to the Test: Climate Change, Militarism, and the Pedagogy of Hopefulness

ERIC Educational Resources Information Center

Amster, Randall

2014-01-01

Climate change and militarism pose existential threats to human existence, and are linked through a number of related processes including access to resources, patterns of consumption, and the workings of the global economy. As nations increasingly militarize their domestic affairs and international postures alike, such patterns can feed back into…

42 CFR 82.30 - How will NIOSH inform the public of any plans to change scientific elements underlying the dose...

Code of Federal Regulations, 2010 CFR

2010-10-01

... HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES METHODS FOR... change scientific elements underlying the dose reconstruction process to maintain methods reasonably... methods reasonably current with scientific progress? Periodically, NIOSH will publish a notice in the...

Narrative Inquiry: A Dynamic Relationship between Culture, Language and Education

ERIC Educational Resources Information Center

Chan, Esther Yim Mei

2017-01-01

Human development is a cultural process, and language serves as a cultural tool is closely related to virtually all the cognitive changes. The author addresses issues of language in education, and suggests that changing the medium of instruction should not be understood as purely a pedagogical decision. The connection between culture and language…

The Southern Appalachians: A History of the Landscape

Treesearch

Susan L. Yarnell

1998-01-01

Natural and geological processes have changed the Southern Appalachian landscape repeatedly over millions of years. About 12,000 years ago, humans arrived and became important agents of change. People affected their environment by hunting, by spreading the seeds of plants they had gathered, by disturbing the vegetation around their habitations, and by increasing the...

Prenatal androgen exposure alters girls' responses to information indicating gender-appropriate behaviour

PubMed Central

Hines, Melissa; Pasterski, Vickie; Spencer, Debra; Neufeld, Sharon; Patalay, Praveetha; Hindmarsh, Peter C.; Hughes, Ieuan A.; Acerini, Carlo L.

2016-01-01

Individual variability in human gender-related behaviour is influenced by many factors, including androgen exposure prenatally, as well as self-socialization and socialization by others postnatally. Many studies have looked at these types of influences in isolation, but little is known about how they work together. Here, we report that girls exposed to high concentrations of androgens prenatally, because they have the genetic condition congenital adrenal hyperplasia, show changes in processes related to self-socialization of gender-related behaviour. Specifically, they are less responsive than other girls to information that particular objects are for girls and they show reduced imitation of female models choosing particular objects. These findings suggest that prenatal androgen exposure may influence subsequent gender-related behaviours, including object (toy) choices, in part by changing processes involved in the self-socialization of gendered behaviour, rather than only by inducing permanent changes in the brain during early development. In addition, the findings suggest that some of the behavioural effects of prenatal androgen exposure might be subject to alteration by postnatal socialization processes. The findings also suggest a previously unknown influence of early androgen exposure on later processes involved in self-socialization of gender-related behaviour, and thus expand understanding of the developmental systems regulating human gender development. PMID:26833843

Prenatal androgen exposure alters girls' responses to information indicating gender-appropriate behaviour.

PubMed

Hines, Melissa; Pasterski, Vickie; Spencer, Debra; Neufeld, Sharon; Patalay, Praveetha; Hindmarsh, Peter C; Hughes, Ieuan A; Acerini, Carlo L

2016-02-19

Individual variability in human gender-related behaviour is influenced by many factors, including androgen exposure prenatally, as well as self-socialization and socialization by others postnatally. Many studies have looked at these types of influences in isolation, but little is known about how they work together. Here, we report that girls exposed to high concentrations of androgens prenatally, because they have the genetic condition congenital adrenal hyperplasia, show changes in processes related to self-socialization of gender-related behaviour. Specifically, they are less responsive than other girls to information that particular objects are for girls and they show reduced imitation of female models choosing particular objects. These findings suggest that prenatal androgen exposure may influence subsequent gender-related behaviours, including object (toy) choices, in part by changing processes involved in the self-socialization of gendered behaviour, rather than only by inducing permanent changes in the brain during early development. In addition, the findings suggest that some of the behavioural effects of prenatal androgen exposure might be subject to alteration by postnatal socialization processes. The findings also suggest a previously unknown influence of early androgen exposure on later processes involved in self-socialization of gender-related behaviour, and thus expand understanding of the developmental systems regulating human gender development. © 2016 The Author(s).

Efficient Processing of the Immunodominant, HLA-A*0201-Restricted Human Immunodeficiency Virus Type 1 Cytotoxic T-Lymphocyte Epitope despite Multiple Variations in the Epitope Flanking Sequences

PubMed Central

Brander, Christian; Yang, Otto O.; Jones, Norman G.; Lee, Yun; Goulder, Philip; Johnson, R. Paul; Trocha, Alicja; Colbert, David; Hay, Christine; Buchbinder, Susan; Bergmann, Cornelia C.; Zweerink, Hans J.; Wolinsky, Steven; Blattner, William A.; Kalams, Spyros A.; Walker, Bruce D.

1999-01-01

Immune escape from cytotoxic T-lymphocyte (CTL) responses has been shown to occur not only by changes within the targeted epitope but also by changes in the flanking sequences which interfere with the processing of the immunogenic peptide. However, the frequency of such an escape mechanism has not been determined. To investigate whether naturally occurring variations in the flanking sequences of an immunodominant human immunodeficiency virus type 1 (HIV-1) Gag CTL epitope prevent antigen processing, cells infected with HIV-1 or vaccinia virus constructs encoding different patient-derived Gag sequences were tested for recognition by HLA-A*0201-restricted, p17-specific CTL. We found that the immunodominant p17 epitope (SL9) and its variants were efficiently processed from minigene expressing vectors and from six HIV-1 Gag variants expressed by recombinant vaccinia virus constructs. Furthermore, SL9-specific CTL clones derived from multiple donors efficiently inhibited virus replication when added to HLA-A*0201-bearing cells infected with primary or laboratory-adapted strains of virus, despite the variability in the SL9 flanking sequences. These data suggest that escape from this immunodominant CTL response is not frequently accomplished by changes in the epitope flanking sequences. PMID:10559335

Simulating tropical carbon stocks and fluxes in a changing world using an individual-based forest model.

NASA Astrophysics Data System (ADS)

Fischer, Rico; Huth, Andreas

2014-05-01

Large areas of tropical forests are disturbed due to climate change and human influence. Experts estimate that the last remaining rainforests could be destroyed in less than 100 years with strong consequences for both developing and industrial countries. Using a modelling approach we analyse how disturbances modify carbon stocks and carbon fluxes of African rainforests. In this study we use the process-based, individual-oriented forest model FORMIND. The main processes of this model are tree growth, mortality, regeneration and competition. The study regions are tropical rainforests in the Kilimanjaro region and Madagascar. Modelling above and below ground carbon stocks, we analyze the impact of disturbances and climate change on forest dynamics and forest carbon stocks. Droughts and fire events change the structure of tropical rainforests. Human influence like logging intensify this effect. With the presented results we could establish new allometric relationships between forest variables and above ground carbon stocks in tropical regions. Using remote sensing techniques, these relationships would offer the possibility for a global monitoring of the above ground carbon stored in the vegetation.

Establishing a culture for patient safety - the role of education.

PubMed

Milligan, Frank J

2007-02-01

This paper argues that the process of making significant moves towards a patient safety culture requires changes in healthcare education. Improvements in patient safety are a shared international priority as too many errors and other forms of unnecessary harm are currently occurring in the process of caring for and treating patients. A description of the patient safety agenda is given followed by a brief analysis of human factors theory and its use in other safety critical industries, most notably aviation. The all too common problem of drug administration errors is used to illustrate the relevance of human factors theory to healthcare education with specific mention made of the Human Factors Analysis and Classification System (HFACS).

[Does Alzheimer's disease exist in all primates? Alzheimer pathology in non-human primates and its pathophysiological implications (II)].

PubMed

Toledano, A; Álvarez, M I; López-Rodríguez, A B; Toledano-Díaz, A; Fernández-Verdecia, C I

2014-01-01

In the ageing process there are some species of non-human primates which can show some of the defining characteristics of the Alzheimer's disease (AD) of man, both in neuropathological changes and cognitive-behavioural symptoms. The study of these species is of prime importance to understand AD and develop therapies to combat this neurodegenerative disease. In this second part of the study, these AD features are discussed in the most important non-experimental AD models (Mouse Lemur -Microcebus murinus, Caribbean vervet -Chlorocebus aethiops, and the Rhesus and stump-tailed macaque -Macaca mulatta and M. arctoides) and experimental models (lesional, neurotoxic, pharmacological, immunological, etc.) non-human primates. In all these models cerebral amyloid neuropathology can occur in senility, although with different levels of incidence (100% in vervets;<30% in macaques). The differences between normal and pathological (Alzheimer's) senility in these species are difficult to establish due to the lack of cognitive-behavioural studies in the many groups analysed, as well as the controversy in the results of these studies when they were carried out. However, in some macaques, a correlation between a high degree of functional brain impairment and a large number of neuropathological changes ("possible AD") has been found. In some non-human primates, such as the macaque, the existence of a possible continuum between "normal" ageing process, "normal" ageing with no deep neuropathological and cognitive-behavioural changes, and "pathological ageing" (or "Alzheimer type ageing"), may be considered. In other cases, such as the Caribbean vervet, neuropathological changes are constant and quite marked, but its impact on cognition and behaviour does not seem to be very important. This does assume the possible existence in the human senile physiological regression of a stable phase without dementia even if neuropathological changes appeared. Copyright © 2011 Sociedad Española de Neurología. Published by Elsevier Espana. All rights reserved.

[Causes for change in producing areas of geo-authentic herbs].

PubMed

Liang, Fei; Li, Jian; Zhang, Wei; Zhang, Rui-Xian

2013-05-01

Geo-authentic herbs lay stress on their producing areas. The producing areas of most geo-authentic herbs have never changed since the ancient times. However, many other geo-authentic herbs have experienced significant changes in the long history. There are two main causes for the change in producing areas of herbs-change of natural environment and development of human society, which are restricted by each other and play a great role throughout the development process of geo-authentic herbs.

Virtual reality: Avatars in human spaceflight training

NASA Astrophysics Data System (ADS)

Osterlund, Jeffrey; Lawrence, Brad

2012-02-01

With the advancements in high spatial and temporal resolution graphics, along with advancements in 3D display capabilities to model, simulate, and analyze human-to-machine interfaces and interactions, the world of virtual environments is being used to develop everything from gaming, movie special affects and animations to the design of automobiles. The use of multiple object motion capture technology and digital human tools in aerospace has demonstrated to be a more cost effective alternative to the cost of physical prototypes, provides a more efficient, flexible and responsive environment to changes in the design and training, and provides early human factors considerations concerning the operation of a complex launch vehicle or spacecraft. United Space Alliance (USA) has deployed this technique and tool under Research and Development (R&D) activities on both spacecraft assembly and ground processing operations design and training on the Orion Crew Module. USA utilizes specialized products that were chosen based on functionality, including software and fixed based hardware (e.g., infrared and visible red cameras), along with cyber gloves to ensure fine motor dexterity of the hands. The key findings of the R&D were: mock-ups should be built to not obstruct cameras from markers being tracked; a mock-up toolkit be assembled to facilitate dynamic design changes; markers should be placed in accurate positions on humans and flight hardware to help with tracking; 3D models used in the virtual environment be striped of non-essential data; high computational capable workstations are required to handle the large model data sets; and Technology Interchange Meetings with vendors and other industries also utilizing virtual reality applications need to occur on a continual basis enabling USA to maintain its leading edge within this technology. Parameters of interest and benefit in human spaceflight simulation training that utilizes virtual reality technologies are to familiarize and assess operational processes, allow the ability to train virtually, experiment with "what if" scenarios, and expedite immediate changes to validate the design implementation are all parameters of interest in human spaceflight. Training benefits encompass providing 3D animation for post-training assessment, placement of avatars within 3D replicated work environments in assembling or processing hardware, offering various viewpoints of processes viewed and assessed giving the evaluators the ability to assess task feasibility and identify potential support equipment needs; and provide human factors determinations, such as reach, visibility, and accessibility. Multiple object motion capture technology provides an effective tool to train and assess ergonomic risks, simulations for determination of negative interactions between technicians and their proposed workspaces, and evaluation of spaceflight systems prior to, and as part of, the design process to contain costs and reduce schedule delays.

Progressive changes in non-coding RNA profile in leucocytes with age

PubMed Central

Muñoz-Culla, Maider; Irizar, Haritz; Gorostidi, Ana; Alberro, Ainhoa; Osorio-Querejeta, Iñaki; Ruiz-Martínez, Javier; Olascoaga, Javier; de Munain, Adolfo López; Otaegui, David

2017-01-01

It has been observed that immune cell deterioration occurs in the elderly, as well as a chronic low-grade inflammation called inflammaging. These cellular changes must be driven by numerous changes in gene expression and in fact, both protein-coding and non-coding RNA expression alterations have been observed in peripheral blood mononuclear cells from elder people. In the present work we have studied the expression of small non-coding RNA (microRNA and small nucleolar RNA -snoRNA-) from healthy individuals from 24 to 79 years old. We have observed that the expression of 69 non-coding RNAs (56 microRNAs and 13 snoRNAs) changes progressively with chronological age. According to our results, the age range from 47 to 54 is critical given that it is the period when the expression trend (increasing or decreasing) of age-related small non-coding RNAs is more pronounced. Furthermore, age-related miRNAs regulate genes that are involved in immune, cell cycle and cancer-related processes, which had already been associated to human aging. Therefore, human aging could be studied as a result of progressive molecular changes, and different age ranges should be analysed to cover the whole aging process. PMID:28448962

Configural processing of biological motion in human superior temporal sulcus.

PubMed

Thompson, James C; Clarke, Michele; Stewart, Tennille; Puce, Aina

2005-09-28

Observers recognize subtle changes in the movements of others with relative ease. However, tracking a walking human is computationally difficult, because the degree of articulation is high and scene changes can temporarily occlude parts of the moving figure. Here, we used functional magnetic resonance imaging to test the hypothesis that the superior temporal sulcus (STS) uses form cues to aid biological movement tracking. The same 10 healthy subjects detected human gait changes in a walking mannequin in two experiments. In experiment 1, we tested the effects of configural change and occlusion. The walking mannequin was presented intact or with the limbs and torso apart in visual space and either unoccluded or occluded by a set of vertical white bars. In experiment 2, the effects of inversion and occlusion were investigated, using an intact walking mannequin. Subjects reliably detected gait changes under all stimulus conditions. The intact walker produced significantly greater activation in the STS, inferior temporal sulcus (ITS), and inferior parietal cortex relative to the apart walker, regardless of occlusion. Interestingly, STS and ITS activation to the upright versus inverted walker was not significantly different. In contrast, superior parietal lobule and parieto-occipital cortex showed greater activation to the apart relative to intact walker. In the absence of an intact body configuration, parietal cortex activity increased to the independent movements of the limbs and torso. Our data suggest that the STS may use a body configuration-based model to process biological movement, thus forming a representation that survives partial occlusion.

Fluvial Sediments as GeoArchives in the Tsauchab Valley, Namibia

NASA Astrophysics Data System (ADS)

Völkel, Jörg; Bens, Oliver; Eden, Marie; Heine, Klaus; Hürkamp, Kerstin

2015-04-01

Understanding the history of how humans have interacted with the landscape can help clarify the options for managing our increasingly interconnected global system. In consequence of changing climate, major regional impacts on the human habitat is expected and must be addressed in modern land-use planning and management strategies which in turn has to rely on a diligent assessment of the nature of possible impacts on regional environments. In warm arid and semi-arid climatic zones, land use can result in landscape degradation, leading to enhanced activity of earth surface processes. Climatic changes can also be instrumental in producing landscape and ecosystem changes, similar to earth surface processes brought about by land-use change. However, predictions of the future behaviour of complex geo/bio-systems are limited, because these are open systems. Apart from modelling a promising approach to better understand the processes of environment responses is to learn lessons from past variability, i.e. searching for 'palaeo-analogue' situations. These are time intervals in the past with boundary conditions (e.g. sea-level changes, atmospheric circulation patterns) more similar to future scenarios than to the present day situation. Signals of these past climate and ecosystem changes are stored in a variety of natural continental and marine archives (sediments, biogens). These geoarchives have the potential for providing researchers with high-resolution data for the reconstruction of palaeo-ecosystems and their dynamics. The influence of key forcing variables and their effects extracted from the geoarchives will be cross-checked in order to validate and adjust models of present and future processes. This knowledge will help justify and calibrate prognostic scenarios in order to deliver proxy-data for southern-hemisphere records. - The project "GeoArchives" is funded by BMBF within the SPACES-Program.

Human Health/Human Factors Considerations in Trans-Lunar Space

NASA Technical Reports Server (NTRS)

Moore, E. Cherice; Howard, Robert; Mendeck, Gavin

2014-01-01

The human factors insights of how they are incorporated into the vehicle are crucial towards designing and planning the internal designs necessary for future spacecraft and missions. The adjusted mission concept of supporting the Asteroid Redirect Crewed Mission will drive some human factors changes on how the Orion will be used and will be reassessed so as to best contribute to missions success. Recognizing what the human factors and health functional needs are early in the design process and how to integrate them will improve this and future generations of space vehicles to achieve mission success and continue to minimize risks.

Cognitive consequences of clumsy automation on high workload, high consequence human performance

NASA Technical Reports Server (NTRS)

Cook, Richard I.; Woods, David D.; Mccolligan, Elizabeth; Howie, Michael B.

1991-01-01

The growth of computational power has fueled attempts to automate more of the human role in complex problem solving domains, especially those where system faults have high consequences and where periods of high workload may saturate the performance capacity of human operators. Examples of these domains include flightdecks, space stations, air traffic control, nuclear power operation, ground satellite control rooms, and surgical operating rooms. Automation efforts may have unanticipated effects on human performance, particularly if they increase the workload at peak workload times or change the practitioners' strategies for coping with workload. Smooth and effective changes in automation requires detailed understanding of the congnitive tasks confronting the user: it has been called user centered automation. The introduction of a new computerized technology in a group of hospital operating rooms used for heart surgery was observed. The study revealed how automation, especially 'clumsy automation', effects practitioner work patterns and suggest that clumsy automation constrains users in specific and significant ways. Users tailor both the new system and their tasks in order to accommodate the needs of process and production. The study of this tailoring may prove a powerful tool for exposing previously hidden patterns of user data processing, integration, and decision making which may, in turn, be useful in the design of more effective human-machine systems.

TRIBES: A New Way of Learning Together.

ERIC Educational Resources Information Center

Gibbs, Jeanne; And Others

Blending the fields of group process and cooperative learning; prevention and resiliency; learning theory; and school change into a comprehensive guide, this book describes the on-going development of the Tribes group process, whereby small learning groups are used to promote human growth and learning. A tribe consists of three to six students who…

Some Interrelationships between Constructivist Models of Learning and Current Neurobiological Theory, with Implications for Science Education.

ERIC Educational Resources Information Center

Anderson, O. Roger

1992-01-01

This paper examines how some fundamental mechanisms of nervous system activity can explain human information processing and the acquisition of knowledge and provides additional theoretical support for constructivist applications to science education reform. The implications for scientific epistemology and conceptual change processes in science…

78 FR 18234 - Service of Process on Manufacturers; Manufacturers Importing Electronic Products Into the United...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-26

... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration 21 CFR Part 1005 [Docket No. FDA-2007-N-0091; (formerly 2007N-0104)] Service of Process on Manufacturers; Manufacturers Importing Electronic Products Into the United States; Agent Designation; Change of Address AGENCY: Food and Drug...

Changes in Information Processing with Aging: Implications for Teaching Motor Skills.

ERIC Educational Resources Information Center

Anshel, Mark H.

Although there are marked individual differences in the effect of aging on learning and performing motor skills, there is agreement that humans process information less efficiently with advanced age. Significant decrements have been found specifically with motor tasks that are characterized as externally-paced, rapid, complex, and requiring rapid…

Mitigation strategies to reduce the generation and transmission of airborne highly pathogenic avian influenza virus particles during processing of infected poultry.

PubMed

Bertran, Kateri; Clark, Andrew; Swayne, David E

2018-06-08

Airborne transmission of H5N1 highly pathogenic avian influenza (HPAI) viruses has occurred among poultry and from poultry to humans during home or live-poultry market slaughter of infected poultry, and such transmission has been experimentally reproduced. In this study, we investigated simple, practical changes in the processing of H5N1 virus-infected chickens to reduce infectious airborne particles and their transmission. Our findings suggest that containing the birds during the killing and bleeding first step by using a disposable plastic bag, a commonly available cooking pot widely used in Egypt (halla), or a bucket significantly reduces generation of infectious airborne particles and transmission to ferrets. Similarly, lack of infectious airborne particles was observed when processing vaccinated chickens that had been challenged with HPAI virus. Moreover, the use of a mechanical defeatherer significantly increased total number of particles in the air compared to manual defeathering. This study confirms that simple changes in poultry processing can efficiently mitigate generation of infectious airborne particles and their transmission to humans. Published by Elsevier GmbH.

Panta Rhei-Everything flows: Global Hotspots of Human-Water Interactions

NASA Astrophysics Data System (ADS)

Di Baldassarre, G.; Srinivasan, V.; Tian, F.; Mohamed, Y.; Krueger, T.; Kreibich, H.; Liu, J.; Troy, T. J.; AghaKouchak, A.

2017-12-01

Panta Rhei-Everything Flows is the scientific decade (2013-2022) of the International Association of Hydrological Sciences (IAHS). This initiative aims to reach an improved interpretation of the processes governing the water cycle by focusing on their changing dynamics in connection with rapidly changing human systems (Montanari et al., 2013; McMillan et al., 2016). More than 400 water scientists have been involved in Panta Rhei so far, and several working groups have produced significant outcomes. In this presentation, we first summarize some key achievements of this initiative by showing how they have advanced our understanding of the way in which humans impact on, and respond to, hydrological change. Then, we suggest simple indicators to characterize interactions between water and human systems. These indicators aim to capture the relevance of human-water interactions and their potential to generate negative effects, such as water crises or unintended consequences. Finally, we show an application of these indicators to global hotspots, i.e. contrasting case studies from around the world. Our goal is to facilitate a community-wide effort in collecting and sharing essential data to map the role of human-water interactions across social and hydrological conditions. ReferencesMontanari et al. (2013) Panta Rhei—Everything Flows: Change in hydrology and society—The IAHS Scientific Decade 2013-2022, Hydrological Sciences Journal, 58(6), 1256-1275. McMillan et al. (2016) Panta Rhei 2013-2015: Global perspectives on hydrology, society and change. Hydrological sciences journal 61(7), 1174-1191.

Evidence for a synchronization of hormonal states between humans and dogs during competition.

PubMed

Buttner, Alicia Phillips; Thompson, Breanna; Strasser, Rosemary; Santo, Jonathan

2015-08-01

Social interactions with humans have been shown to influence hormonal processes in dogs, but it is unclear how the hormonal states of humans factor into this relationship. In this study, we explored the associations between changes in the cortisol levels of dogs with humans' hormonal changes, behavior, and perceptions of their performance at an agility competition. A total of 58 dogs and their handlers (44 women, 14 men) provided saliva samples before and after competing. Dogs' saliva samples were later assayed for cortisol and humans' samples for cortisol and testosterone. Following the competition, handler-dog interactions were observed for affiliative and punitive behavior towards their dogs, and handlers completed questionnaires that included personal ratings of their performance. Structural equation modeling revealed that elevations in handlers' cortisol levels were associated with increases in their dogs' cortisol levels. Handlers' affiliative and punitive behaviors towards their dogs following competition were associated with their ratings of their performance, but these variables were unrelated to changes in their own cortisol levels and their dogs', implying their behavior did not mediate the relationship. These findings suggest that changes in the hormonal states were reflected between humans and their dogs, and this relationship was not due to handlers' perceptions of their performance or the behaviors we observed during post-competition social interactions. This study is one of the first to provide evidence for a synchronization of hormonal changes between species. Copyright © 2015 Elsevier Inc. All rights reserved.

Land-cover change detection

USGS Publications Warehouse

Chen, Xuexia; Giri, Chandra; Vogelmann, James

2012-01-01

Land cover is the biophysical material on the surface of the earth. Land-cover types include grass, shrubs, trees, barren, water, and man-made features. Land cover changes continuously.  The rate of change can be either dramatic and abrupt, such as the changes caused by logging, hurricanes and fire, or subtle and gradual, such as regeneration of forests and damage caused by insects (Verbesselt et al., 2001).  Previous studies have shown that land cover has changed dramatically during the past sevearal centuries and that these changes have severely affected our ecosystems (Foody, 2010; Lambin et al., 2001). Lambin and Strahlers (1994b) summarized five types of cause for land-cover changes: (1) long-term natural changes in climate conditions, (2) geomorphological and ecological processes, (3) human-induced alterations of vegetation cover and landscapes, (4) interannual climate variability, and (5) human-induced greenhouse effect.  Tools and techniques are needed to detect, describe, and predict these changes to facilitate sustainable management of natural resources.

Advances in memory research: single-neuron recordings from the human medial temporal lobe aid our understanding of declarative memory.

PubMed

Viskontas, Indre V

2008-12-01

To gain a complete understanding of how the brain functions, both in illness and good health, data from multiple levels of analysis must be integrated. Technical advances have made direct recordings of neuronal activity deep inside the human brain tractable, providing a rare glimpse into cellular processes during long-term memory formation. Recent findings using intracranial recordings in the medial temporal lobe inform current neural network models of memory, and may lead to a more comprehensive understanding of the neural basis of memory-related processes. These recordings have shown that cells in the hippocampus appear to support declarative learning by distinguishing novel and familiar stimuli via changes in firing patterns. Some cells with highly selective and invariant responses have also been described, and these responses seem to represent abstract concepts such as identity, rather than superficial perceptual features of items. Importantly, however, both selective and globally responsive cells are capable of changing their preferred stimulus depending on the conscious demands of the task. Firing patterns of human medial temporal lobe neurons indicate that cells can be both plastic and stable in terms of the information that they code; although some cells show highly selective and reproducible excitatory responses when presented with a familiar object, other cells change their receptive fields in line with changes in experience and the cognitive environment.

Functional Relationships for Investigating Cognitive Processes

PubMed Central

Wright, Anthony A.

2013-01-01

Functional relationships (from systematic manipulation of critical variables) are advocated for revealing fundamental processes of (comparative) cognition—through examples from my work in psychophysics, learning, and memory. Functional relationships for pigeon wavelength (hue) discrimination revealed best discrimination at the spectral points of hue transition for pigeons—a correspondence (i.e., functional relationship) similar to that for humans. Functional relationships for learning revealed: Item-specific or relational learning in matching to sample as a function of the pigeons’ sample-response requirement, and same/different abstract-concept learning as a function of the training set size for rhesus monkeys, capuchin monkeys, and pigeons. Functional relationships for visual memory revealed serial position functions (a 1st order functional relationship) that changed systematically with retention delay (a 2nd order relationship) for pigeons, capuchin monkeys, rhesus monkeys, and humans. Functional relationships for rhesus-monkey auditory memory also revealed systematic changes in serial position functions with delay, but these changes were opposite to those for visual memory. Functional relationships for proactive interference revealed interference that varied as a function of a ratio of delay times. Functional relationships for change detection memory revealed (qualitative) similarities and (quantitative) differences in human and monkey visual short term memory as a function of the number of memory items. It is concluded that these findings were made possible by varying critical variables over a substantial portion of the manipulable range to generate functions and derive relationships. PMID:23174335

All is not loss: plant biodiversity in the anthropocene.

PubMed

Ellis, Erle C; Antill, Erica C; Kreft, Holger

2012-01-01

Anthropogenic global changes in biodiversity are generally portrayed in terms of massive native species losses or invasions caused by recent human disturbance. Yet these biodiversity changes and others caused directly by human populations and their use of land tend to co-occur as long-term biodiversity change processes in the Anthropocene. Here we explore contemporary anthropogenic global patterns in vascular plant species richness at regional landscape scales by combining spatially explicit models and estimates for native species loss together with gains in exotics caused by species invasions and the introduction of agricultural domesticates and ornamental exotic plants. The patterns thus derived confirm that while native losses are likely significant across at least half of Earth's ice-free land, model predictions indicate that plant species richness has increased overall in most regional landscapes, mostly because species invasions tend to exceed native losses. While global observing systems and models that integrate anthropogenic species loss, introduction and invasion at regional landscape scales remain at an early stage of development, integrating predictions from existing models within a single assessment confirms their vast global extent and significance while revealing novel patterns and their potential drivers. Effective global stewardship of plant biodiversity in the Anthropocene will require integrated frameworks for observing, modeling and forecasting the different forms of anthropogenic biodiversity change processes at regional landscape scales, towards conserving biodiversity within the novel plant communities created and sustained by human systems.

All Is Not Loss: Plant Biodiversity in the Anthropocene

PubMed Central

Ellis, Erle C.; Antill, Erica C.; Kreft, Holger

2012-01-01

Anthropogenic global changes in biodiversity are generally portrayed in terms of massive native species losses or invasions caused by recent human disturbance. Yet these biodiversity changes and others caused directly by human populations and their use of land tend to co-occur as long-term biodiversity change processes in the Anthropocene. Here we explore contemporary anthropogenic global patterns in vascular plant species richness at regional landscape scales by combining spatially explicit models and estimates for native species loss together with gains in exotics caused by species invasions and the introduction of agricultural domesticates and ornamental exotic plants. The patterns thus derived confirm that while native losses are likely significant across at least half of Earth's ice-free land, model predictions indicate that plant species richness has increased overall in most regional landscapes, mostly because species invasions tend to exceed native losses. While global observing systems and models that integrate anthropogenic species loss, introduction and invasion at regional landscape scales remain at an early stage of development, integrating predictions from existing models within a single assessment confirms their vast global extent and significance while revealing novel patterns and their potential drivers. Effective global stewardship of plant biodiversity in the Anthropocene will require integrated frameworks for observing, modeling and forecasting the different forms of anthropogenic biodiversity change processes at regional landscape scales, towards conserving biodiversity within the novel plant communities created and sustained by human systems. PMID:22272360

Assessing and managing multiple risks in a changing world-The Roskilde recommendations.

PubMed

Selck, Henriette; Adamsen, Peter B; Backhaus, Thomas; Banta, Gary T; Bruce, Peter K H; Burton, G Allen; Butts, Michael B; Boegh, Eva; Clague, John J; Dinh, Khuong V; Doorn, Neelke; Gunnarsson, Jonas S; Hauggaard-Nielsen, Henrik; Hazlerigg, Charles; Hunka, Agnieszka D; Jensen, John; Lin, Yan; Loureiro, Susana; Miraglia, Simona; Munns, Wayne R; Nadim, Farrokh; Palmqvist, Annemette; Rämö, Robert A; Seaby, Lauren P; Syberg, Kristian; Tangaa, Stine R; Thit, Amalie; Windfeld, Ronja; Zalewski, Maciej; Chapman, Peter M

2017-01-01

Roskilde University (Denmark) hosted a November 2015 workshop, Environmental Risk-Assessing and Managing Multiple Risks in a Changing World. This Focus article presents the consensus recommendations of 30 attendees from 9 countries regarding implementation of a common currency (ecosystem services) for holistic environmental risk assessment and management; improvements to risk assessment and management in a complex, human-modified, and changing world; appropriate development of protection goals in a 2-stage process; dealing with societal issues; risk-management information needs; conducting risk assessment of risk management; and development of adaptive and flexible regulatory systems. The authors encourage both cross-disciplinary and interdisciplinary approaches to address their 10 recommendations: 1) adopt ecosystem services as a common currency for risk assessment and management; 2) consider cumulative stressors (chemical and nonchemical) and determine which dominate to best manage and restore ecosystem services; 3) fully integrate risk managers and communities of interest into the risk-assessment process; 4) fully integrate risk assessors and communities of interest into the risk-management process; 5) consider socioeconomics and increased transparency in both risk assessment and risk management; 6) recognize the ethical rights of humans and ecosystems to an adequate level of protection; 7) determine relevant reference conditions and the proper ecological context for assessments in human-modified systems; 8) assess risks and benefits to humans and the ecosystem and consider unintended consequences of management actions; 9) avoid excessive conservatism or possible underprotection resulting from sole reliance on binary, numerical benchmarks; and 10) develop adaptive risk-management and regulatory goals based on ranges of uncertainty. Environ Toxicol Chem 2017;36:7-16. © 2016 SETAC. © 2016 SETAC.

Internal structural changes in keratin fibres resulting from combined hair waving and stress relaxation treatments: a Raman spectroscopic investigation.

PubMed

Kuzuhara, A

2016-04-01

The objective of our research was to investigate the influence of chemical treatments (reduction, stress relaxation and oxidation) on hair keratin fibres. The structure of cross-sections at various depths of virgin white human hair resulting from permanent waving treatments with stress relaxation process was directly analysed at a molecular level using Raman spectroscopy. In particular, the three disulphide (-SS-) conformations in human hair were compared by S-S band analysis. The gauche-gauche-gauche (GGG) and gauche-gauche-trans (GGT) contents of -SS- groups remarkably decreased, while the trans-gauche-trans (TGT) content was not changed by performing the reduction process with thioglycolic acid. In addition, the high-temperature stress relaxation process after reduction accelerated the disconnection of -SS- (GGG and GGT) groups in the human hair, while the low-temperature stress relaxation process after reduction accelerated the reconnection of -SS- (GGG and GGT) groups. Moreover, the S-O band intensity at 1042 cm(-1) , assigned to cysteic acid, existing in the cuticle region and the surface of the cortex region increased, while the GGG content significantly decreased by performing the oxidation process after the reduction and the high-temperature stress relaxation processes. The author concluded that the high-temperature relaxation process after reduction accelerated the disconnection of -SS- (GGG and GGT) groups, thereby leading to the remarkable local molecular disorganization (an increase in the cysteic acid content and a decrease in the GGG content) on the cuticle and cortex cells during the oxidation process. © 2015 Society of Cosmetic Scientists and the Société Française de Cosmétologie.

How do organizations and social policies 'acculturate' to immigrants? Accommodating skilled immigrants in Canada.

PubMed

Sakamoto, Izumi; Wei, Yi; Truong, Lele

2008-12-01

While the idea of acculturation (Berry 1997) was originally proposed as the mutual change of both parties (e.g., immigrants and the host society), the change processes of host societies are neglected in research. A grounded theory study explored the efforts of human service organizations to 'acculturate' to an increasingly diverse immigrant population, through interviews conducted with service providers serving Mainland Chinese immigrants. Acculturation efforts of human service organizations (mezzo-level acculturation) were often needs-driven and affected by the political will and resultant funding programs (macro-level forces). Even with limitations, human service organizations commonly focused on hiring Mainland Chinese immigrants to reflect the changing demographics of their clientele and creating new programs to meet the language and cultural backgrounds of the clients. To contextualize these organizational efforts, an analysis of how policy changes (macro-level acculturation) interact with organizational practice is presented. Finally, the meaning of acculturation for the host society is discussed.

[Significance of emotion-focused concepts to cognitive-behavioral therapy].

PubMed

Lammers, C-H

2006-09-01

Emotions are the central process of motivation and play a key role in adaptive behavior in humans. Although cognitive-behavioral therapy stresses the importance of changing both cognition and behavior, there is growing emphasis on direct therapeutic work on emotions and emotional processing, as problematic emotional processes are at the core of nearly all psychic disorders. This type of work is the goal of emotion-focused psychotherapy, which centers on direct change of problematic emotions, especially those which are usually suppressed resp. overregulated by the patient. This paper examines the basic phobic/emotional conflict, the problematic emotional processes arising from this conflict, and the importance to cognitive-behavioral therapy of their potentially integrative role.

Linked Open Data in the Global Change Information System (GCIS)

NASA Technical Reports Server (NTRS)

Tilmes, Curt A.

2012-01-01

The U.S. Global Change Research Program (http://globalchange.gov) coordinates and integrates federal research on changes in the global environment and their implications for society. The USGCRP is developing a Global Change Information System (GCIS) that will centralize access to data and information related to global change across the U.S. federal government. The first implementation will focus on the 2013 National Climate Assessment (NCA) . (http://assessment.globalchange.gov) The NCA integrates, evaluates, and interprets the findings of the USGCRP; analyzes the effects of global change on the natural environment, agriculture, energy production and use, land and water resources, transportation, human health and welfare, human social systems, and biological diversity; and analyzes current trends in global change, both human-induced and natural, and projects major trends for the subsequent 25 to 100 years. The NCA has received over 500 distinct technical inputs to the process, many of which are reports distilling and synthesizing even more information, coming from thousands of individuals around the federal, state and local governments, academic institutions and non-governmental organizations. The GCIS will present a web-based version of the NCA including annotations linking the findings and content of the NCA with the scientific research, datasets, models, observations, etc. that led to its conclusions. It will use semantic tagging and a linked data approach, assigning globally unique, persistent, resolvable identifiers to all of the related entities and capturing and presenting the relationships between them, both internally and referencing out to other linked data sources and back to agency data centers. The developing W3C PROV Data Model and ontology will be used to capture the provenance trail and present it in both human readable web pages and machine readable formats such as RDF and SPARQL. This will improve visibility into the assessment process, increase understanding and reproducibility, and ultimately increase credibility and trust of the resulting report. Building on the foundation of the NCA, longer term plans for the GCIS include extending these capabilities throughout the U.S. Global Change Research Program, centralizing access to global change data and information across the thirteen agencies that comprise the program.

Internal structure changes in bleached black human hair resulting from chemical treatments: A Raman spectroscopic investigation

NASA Astrophysics Data System (ADS)

Kuzuhara, Akio

2014-11-01

In order to investigate in detail the influence of chemical treatments (reduction, hydrolyzed eggwhite protein (HEWP) treatment, and oxidation) on damaged hair keratin fibers, the structure of cross-sections at various depths of excessively bleached (damaged) black human hair resulting from a permanent waving process was directly analyzed using Raman spectroscopy. It was found that L-cysteine (CYS) largely reacted with the gauche-gauche-gauche (GGG) conformation of disulfide (-SS-) groups (while CYS did not react with the trans-gauche-trans (TGT) conformation). In particular, not only the GGG content, but also the cysteic acid content existing throughout the cortex region of the excessively bleached human hair remarkably decreased by performing the oxidation process after reduction. On the other hand, the GGG content of the excessively bleached black human hair increased, while the TGT content decreased by performing the oxidation process after reduction and then HEWP treatment processes. From these experiments, the authors concluded that some of the keratin associated protein (KAP), which has a rich -SS- content and cysteic acid content was eluted from the cortex region along with the disconnection of -SS- groups, thereby leading to the remarkable reduction in the reconnection of -SS- groups of the excessively bleached black human hair after the permanent waving process (the reduction and oxidation processes). Also, the authors concluded that the HEWP treatment process in the permanent waving process caused the reconstruction of the KAP, thereby contributing to the acceleration of the reconnection of -SS- groups during the oxidation process.

Studies of the Processing of Single Words Using Positron Tomographic Measures of Cerebral Blood Flow Change.

DTIC Science & Technology

1987-01-01

BLOOD FLOW CHANGE Steven E. Petersen, Peter T. Fox, Michael I. Posner, Marcus Raichle McDonnell Center for Studies of Higher Brain Function...Single Words Using Positron Emission Tomographic Measurements of Cerebral Blood Flow Change *= ’I PERSONAL AUTHOR(S) * Petersen, Steven E. 13a. TYPE OF...CHANGE Steven E. Petersen, Peter T. Fox, Michael I. Posner, Marcus E. Raichle INTRODUCTION Language is an essential characteristic of the human

Understanding the Dynamics of Socio-Hydrological Environment: a Conceptual Framework

NASA Astrophysics Data System (ADS)

Woyessa, Y.; Welderufael, W.; Edossa, D.

2011-12-01

Human actions affect ecological systems and the services they provide through various activities, such as land use, water use, pollution and climate change. Climate change is perhaps one of the most important sustainable development challenges that threaten to undo many of the development efforts being made to reach the targets set for the Millennium Development Goals. Understanding the change of ecosystems under different scenarios of climate and biophysical conditions could assist in bringing the issue of ecosystem services into decision making process. Similarly, the impacts of land use change on ecosystems and biodiversity have received considerable attention from ecologists and hydrologists alike. Land use change in a catchment can impact on water supply by altering hydrological processes, such as infiltration, groundwater recharge, base flow and direct runoff. In the past a variety of models were used for predicting land-use changes. Recently the focus has shifted away from using mathematically oriented models to agent-based modelling (ABM) approach to simulate land use scenarios. A conceptual framework is being developed which integrates climate change scenarios and the human dimension of land use decision into a hydrological model in order to assess its impacts on the socio-hydrological dynamics of a river basin. The following figures present the framework for the analysis and modelling of the socio-hydrological dynamics. Keywords: climate change, land use, river basin

Freedom: A Promise of Possibility.

PubMed

Bunkers, Sandra Schmidt

2015-10-01

The idea of freedom as a promise of possibility is explored in this column. The core concepts from a research study on considering tomorrow (Bunkers, 1998) coupled with humanbecoming community change processes (Parse, 2003) are used to illuminate this notion. The importance of intentionality in human freedom is discussed from both a human science and a natural science perspective. © The Author(s) 2015.

Multivoxel pattern similarity suggests the integration of temporal duration in hippocampal event sequence representations.

PubMed

Thavabalasingam, Sathesan; O'Neil, Edward B; Lee, Andy C H

2018-05-22

Recent rodent work suggests the hippocampus may provide a temporal representation of event sequences, in which the order of events and the interval durations between them are encoded. There is, however, limited human evidence for the latter, in particular whether the hippocampus processes duration information pertaining to the passage of time rather than qualitative or quantitative changes in event content. We scanned participants while they made match-mismatch judgements on each trial between a study sequence of events and a subsequent test sequence. Participants explicitly remembered event order or interval duration information (Experiment 1), or monitored order only, with duration being manipulated implicitly (Experiment 2). Hippocampal study-test pattern similarity was significantly reduced by changes to order or duration in mismatch trials, even when duration was processed implicitly. Our findings suggest the human hippocampus processes short intervals within sequences and support the idea that duration information is integrated into hippocampal mnemonic representations. Copyright © 2018 Elsevier Inc. All rights reserved.

Quantifying Anthropogenic Dust Emissions

NASA Astrophysics Data System (ADS)

Webb, Nicholas P.; Pierre, Caroline

2018-02-01

Anthropogenic land use and land cover change, including local environmental disturbances, moderate rates of wind-driven soil erosion and dust emission. These human-dust cycle interactions impact ecosystems and agricultural production, air quality, human health, biogeochemical cycles, and climate. While the impacts of land use activities and land management on aeolian processes can be profound, the interactions are often complex and assessments of anthropogenic dust loads at all scales remain highly uncertain. Here, we critically review the drivers of anthropogenic dust emission and current evaluation approaches. We then identify and describe opportunities to: (1) develop new conceptual frameworks and interdisciplinary approaches that draw on ecological state-and-transition models to improve the accuracy and relevance of assessments of anthropogenic dust emissions; (2) improve model fidelity and capacity for change detection to quantify anthropogenic impacts on aeolian processes; and (3) enhance field research and monitoring networks to support dust model applications to evaluate the impacts of disturbance processes on local to global-scale wind erosion and dust emissions.

Labor of love. A model for planning human resource needs.

PubMed

Brady, F J

1989-01-01

Typically, the annual budgeting process is the hospital's only attempt to forecast human resource requirements. In times of rapid change, this traditional ad hoc approach is incapable of satisfying either the Catholic hospital's ethical obligations as an employer or its responsibilities to provide healthcare to the poor and suffering. Assumptions about future activity, including volume projections on admissions, patient days, and other services, influence the budgeting process to a large degree. Because the amount of work to be done and the number of employees required to do it are related, changes in demand for service immediately and directly affect staffing requirements. A hospital cannot achieve ethical human resource management or provide high-quality healthcare if inadequate planning forces management into a cycle of crisis-coping--reacting to this year's nursing shortage with a major recruiting effort and next year's financial crunch with a traumatic reduction in force. The human resource planning approach outlined here helps the hospital meet legitimate business needs while satisfying its ethical obligations. The model has four phases and covers a charge to the planning committee; committee appointments; announcements; the establishment of ground rules, focus, and task forces; and the work of each task force.

Assessing and managing multiple risks in a changing world ...

EPA Pesticide Factsheets

Roskilde University (Denmark) hosted a November 2015 workshop, Environmental Risk—Assessing and Managing Multiple Risks in a Changing World. This Focus article presents the consensus recommendations of 30 attendees from 9 countries regarding implementation of a common currency (ecosystem services) for holistic environmental risk assessment and management; improvements to risk assessment and management in a complex, human-modified, and changing world; appropriate development of protection goals in a 2-stage process; dealing with societal issues; risk-management information needs; conducting risk assessment of risk management; and development of adaptive and flexible regulatory systems. The authors encourage both cross-disciplinary and interdisciplinary approaches to address their 10 recommendations: 1) adopt ecosystem services as a common currency for risk assessment and management; 2) consider cumulative stressors (chemical and nonchemical) and determine which dominate to best manage and restore ecosystem services; 3) fully integrate risk managers and communities of interest into the risk-assessment process; 4) fully integrate risk assessors and communities of interest into the risk-management process; 5) consider socioeconomics and increased transparency in both risk assessment and risk management; 6) recognize the ethical rights of humans and ecosystems to an adequate level of protection; 7) determine relevant reference conditions and the proper ecological c

Development, epigenetics and metabolic programming

PubMed Central

Godfrey, Keith M; Costello, Paula; Lillycrop, Karen

2016-01-01

It is now widely recognised that the environment in early life can have important effects on human growth and development, including the “programming” of far reaching effects on the risk of developing common metabolic and other non-communicable diseases in later life. We have shown that greater childhood adiposity is associated with higher maternal adiposity, low maternal vitamin D status, excessive gestational weight gain, and short duration of breastfeeding; maternal dietary patterns in pregnancy and vitamin D status have been linked with childhood bone mineral content and muscle function. Human studies have identified fetal liver blood flow adaptations and epigenetic changes as potential mechanisms that could link maternal influences with offspring body composition. In experimental studies there is now substantial evidence that the environment during early life induces altered phenotypes through epigenetic mechanisms. Epigenetic processes such as DNA methylation, covalent modifications of histones and non-coding RNAs can induce changes in gene expression without a change in DNA base sequence. Such processes are involved in cell differentiation and genomic imprinting, as well as the phenomenon of developmental plasticity in response to environmental influences. Elucidation of such epigenetic processes may enable early intervention strategies to improve early development and growth. PMID:27088334

Assessing and Managing Multiple Risks in a Changing World ...

EPA Pesticide Factsheets

Roskilde University hosted a November 2015 workshop on “Environmental Risk – Assessing and Managing Multiple Risks in a Changing World”. Thirty attendees from 9 countries developed consensus recommendations regarding: implementation of a common currency (ecosystem services) for holistic environmental risk assessment and management; improvements to risk assessment and management in a complex, human-modified, and changing world; appropriate development of protection goals in a 2-stage process involving both universal and site-, region-, or problem-specific protection goals; addressing societal issues; risk management information needs; conducting risk assessment of risk management; and development of adaptive and flexible regulatory systems. We encourage both cross- and inter-disciplinary approaches to address 10 recommendations: 1) adopt ecosystem services as a common currency for risk assessment and management; 2) consider cumulative stressors (chemical and non-chemical) and determine which dominate to best manage and restore ecosystem services; 3) fully integrate risk managers and communities of interest into the risk assessment process; 4) fully integrate risk assessors and communities of interest into the risk management process; 5) consider socio-economics and increase transparency in both risk assessment and risk management; 6) recognize the ethical rights of humans and ecosystems to an adequate level of protection; 7) determine relevant reference con

Aspects of human biometeorology in past, present and future.

PubMed

Höppe, P

1997-02-01

Human biometeorology is quite an old science: during the times of Hippokrates in ancient Greece the influence of weather changes on physiological processes in the human body were considered to exist. However, not until the progress in modern statistics, physics and physiology in the course of this century provided quantitative methods did human-biometeorology become an acknowledged natural science. In the first half of this century primarily the explanation of the phenomena of reactions of the body to weather changes was the general objective. In the second half of this century quantitative descriptions of thermal interchanges between the human body and the environment by means of energy balance models of the human body have gained increasing importance. The methods of modern human biometeorology increasingly are acknowledged by workers in disciplines of potential application, such as urban or regional planners or air conditioning engineers. Human biometeorology tries to assess all atmospheric influences in its entirety, including the air pollution pattern. The discipline considers itself as branch of science which is tied closely to environmental meteorology and environmental medicine.

The change of European landscapes: human-nature relationships, public attitudes towards rewilding, and the implications for landscape management in Switzerland.

PubMed

Bauer, Nicole; Wallner, Astrid; Hunziker, Marcel

2009-07-01

The rewilding of landscapes is one of the most important and intensively discussed landscape changes occurring in Switzerland, as the need for agricultural and forest land is decreasing. To ensure that decisions concerning future landscape management will be supported by the public, it is crucial to take public opinion into account. Hence the present study aims to assess the public attitudes towards nature and "rewilding" processes. In order to analyze these attitudes, we sent a standardized questionnaire to 4000 randomly selected households throughout Switzerland. A cluster analysis led to a typology with four different types of human-nature relationship ("nature lovers", "nature sympathizers", "nature-connected users" and "nature controllers") that each characterize a particular attitude towards nature. These human-nature relationship types differ in their attitudes towards rewilding as well, allowing a rough classification of the sample into wilderness opponents (51.1%) and wilderness proponents (49.9%). However both groups agree with regard to their opinion concerning the rules and regulations that should apply in future wilderness areas. The parallels of the human-nature relationship typology of this survey with other typologies, and the implications for further research are discussed. We can conclude that, due to the differences concerning the attitudes towards wilderness between the human-nature relationship types, between the rural and urban dwellers, and between the language regions, a uniform strategy for the designation and management of wilderness areas in Switzerland is not possible. We recommend that, when managing landscape change, all stakeholders are included in a participatory process and we advise a thorough assessment of the attitudes of the involved persons towards nature and rewilding at the start of such processes. Such an assessment would facilitate the identification of well-defined target groups allowing specific interventions and management actions customized to the needs and characteristics of each of these groups. In addition we see the commonalities between wilderness opponents and wilderness proponents concerning the rules in wilderness areas as an ideal starting point for a successful participatory process.

Quantifying long-term human impact in contrasting environments: Statistical analysis of modern and fossil pollen records

NASA Astrophysics Data System (ADS)

Broothaerts, Nils; López-Sáez, José Antonio; Verstraeten, Gert

2017-04-01

Reconstructing and quantifying human impact is an important step to understand human-environment interactions in the past. Quantitative measures of human impact on the landscape are needed to fully understand long-term influence of anthropogenic land cover changes on the global climate, ecosystems and geomorphic processes. Nevertheless, quantifying past human impact is not straightforward. Recently, multivariate statistical analysis of fossil pollen records have been proposed to characterize vegetation changes and to get insights in past human impact. Although statistical analysis of fossil pollen data can provide useful insights in anthropogenic driven vegetation changes, still it cannot be used as an absolute quantification of past human impact. To overcome this shortcoming, in this study fossil pollen records were included in a multivariate statistical analysis (cluster analysis and non-metric multidimensional scaling (NMDS)) together with modern pollen data and modern vegetation data. The information on the modern pollen and vegetation dataset can be used to get a better interpretation of the representativeness of the fossil pollen records, and can result in a full quantification of human impact in the past. This methodology was applied in two contrasting environments: SW Turkey and Central Spain. For each region, fossil pollen data from different study sites were integrated, together with modern pollen data and information on modern vegetation. In this way, arboreal cover, grazing pressure and agricultural activities in the past were reconstructed and quantified. The data from SW Turkey provides new integrated information on changing human impact through time in the Sagalassos territory, and shows that human impact was most intense during the Hellenistic and Roman Period (ca. 2200-1750 cal a BP) and decreased and changed in nature afterwards. The data from central Spain shows for several sites that arboreal cover decreases bellow 5% from the Feudal period onwards (ca. 850 cal a BP) related to increasing human impact in the landscape. At other study sites arboreal cover remained above 25% beside significant human impact. Overall, the presented examples from two contrasting environments shows how cluster analysis and NMDS of modern and fossil pollen data can help to provide quantitative insights in anthropogenic land cover changes. Our study extensively discuss and illustrate the possibilities and limitations of statistical analysis of pollen data to quantify human induced land use changes.

Major transitions in human evolution.

PubMed

Foley, Robert A; Martin, Lawrence; Mirazón Lahr, Marta; Stringer, Chris

2016-07-05

Evolutionary problems are often considered in terms of 'origins', and research in human evolution seen as a search for human origins. However, evolution, including human evolution, is a process of transitions from one state to another, and so questions are best put in terms of understanding the nature of those transitions. This paper discusses how the contributions to the themed issue 'Major transitions in human evolution' throw light on the pattern of change in hominin evolution. Four questions are addressed: (1) Is there a major divide between early (australopithecine) and later (Homo) evolution? (2) Does the pattern of change fit a model of short transformations, or gradual evolution? (3) Why is the role of Africa so prominent? (4) How are different aspects of adaptation-genes, phenotypes and behaviour-integrated across the transitions? The importance of developing technologies and approaches and the enduring role of fieldwork are emphasized.This article is part of the themed issue 'Major transitions in human evolution'. © 2016 The Author(s).

Major transitions in human evolution

PubMed Central

Foley, Robert A.; Martin, Lawrence; Mirazón Lahr, Marta; Stringer, Chris

2016-01-01

Evolutionary problems are often considered in terms of ‘origins', and research in human evolution seen as a search for human origins. However, evolution, including human evolution, is a process of transitions from one state to another, and so questions are best put in terms of understanding the nature of those transitions. This paper discusses how the contributions to the themed issue ‘Major transitions in human evolution’ throw light on the pattern of change in hominin evolution. Four questions are addressed: (1) Is there a major divide between early (australopithecine) and later (Homo) evolution? (2) Does the pattern of change fit a model of short transformations, or gradual evolution? (3) Why is the role of Africa so prominent? (4) How are different aspects of adaptation—genes, phenotypes and behaviour—integrated across the transitions? The importance of developing technologies and approaches and the enduring role of fieldwork are emphasized. This article is part of the themed issue ‘Major transitions in human evolution’. PMID:27298461

Deciphering the Swine-Flu Pandemics of 1918 and 2009

NASA Astrophysics Data System (ADS)

Goldstein, Richard; Dos Reis, Mario; Tamuri, Asif; Hay, Alan

The devastating "Spanish flu" of 1918 killed an estimated 50 million people worldwide, ranking it as the deadliest pandemic in recorded human history. It is generally believed that the virus transferred from birds directly to humans shortly before the start of the pandemic, subsequently jumping from humans to swine. By developing 'non-homogeneous' substitution models that consider that substitution patterns may be different in human, avian, and swine hosts, we can determine the timing of the host shift to mammals. We find it likely that the Spanish flu of 1918, like the current 2009 pandemic, was a 'swine-origin' influenza virus. Now that we are faced with a new pandemic, can we understand how influenza is able to change hosts? Again by modelling the evolutionary process, considering the different selective constraints for viruses in the different hosts, we can identify locations that seem to be under different selective constraints in humans and avian hosts. This allows us to identify changes that may have facilitated the establishment of the 2009 swine-origin flu in humans.

Vertex- and atlas-based comparisons in measures of cortical thickness, gyrification and white matter volume between humans and chimpanzees.

PubMed

Hopkins, William D; Li, Xiang; Crow, Tim; Roberts, Neil

2017-01-01

What changes in cortical organisation characterise global and localised variation between humans and chimpanzees remains a topic of considerable interest in evolutionary neuroscience. Here, we examined regional variation in cortical thickness, gyrification and white matter in samples of human and chimpanzee brains. Both species were MRI scanned on the same platform using identical procedures. The images were processed and segmented by FSL and FreeSurfer and the relative changes in cortical thickness, gyrification and white matter across the entire cortex were compared between species. In general, relative to chimpanzees, humans had significantly greater gyrification and significantly thinner cortex, particularly in the frontal lobe. Human brains also had disproportionately higher white matter volumes in the frontal lobe, particularly in prefrontal regions. Collectively, the findings suggest that after the split from the common ancestor, white matter expansion and subsequently increasing gyrification occurred in the frontal lobe possibly due to increased selection for human cognitive and motor specialisations.

Inhalation of 7.5% carbon dioxide increases threat processing in humans.

PubMed

Garner, Matthew; Attwood, Angela; Baldwin, David S; James, Alexandra; Munafò, Marcus R

2011-07-01

Inhalation of 7.5% CO(2) increases anxiety and autonomic arousal in humans, and elicits fear behavior in animals. However, it is not known whether CO(2) challenge in humans induces dysfunction in neurocognitive processes that characterize generalized anxiety, notably selective attention to environmental threat. Healthy volunteers completed an emotional antisaccade task in which they looked toward or away from (inhibited) negative and neutral stimuli during inhalation of 7.5% CO(2) and air. CO(2) inhalation increased anxiety, autonomic arousal, and erroneous eye movements toward threat on antisaccade trials. Autonomic response to CO(2) correlated with hypervigilance to threat (speed to initiate prosaccades) and reduced threat inhibition (increased orienting toward and slower orienting away from threat on antisaccade trials) independent of change in mood. Findings extend evidence that CO(2) triggers fear behavior in animals via direct innervation of a distributed fear network that mobilizes the detection of and allocation of processing resources toward environmental threat in humans.

Analysis of metabolomic profile of fermented Orostachys japonicus A. Berger by capillary electrophoresis time of flight mass spectrometry

PubMed Central

Das, Gitishree; Patra, Jayanta Kumar; Lee, Sun-Young; Kim, Changgeon; Park, Jae Gyu

2017-01-01

Microbial cell performance in food biotechnological processes has become an important concern for improving human health worldwide. Lactobacillus plantarum, which is widely distributed in nature, is a lactic acid bacterium with many industrial applications for fermented foods or functional foods (e.g., probiotics). In the present study, using capillary electrophoresis time of flight mass spectrometry, the metabolomic profile of dried Orostachys japonicus A. Berger, a perennial medicinal herb with L. plantarum was compared with that of O. japonicus fermented with L. plantarum to elucidate the metabolomic changes induced by the fermentation process. The levels of several metabolites were changed by the fermentation process, indicating their involvement in microbial performance. For example, glycolysis, the pentose phosphate pathway, the TCA cycle, the urea cycle-related metabolism, nucleotide metabolism, and lipid and amino acid metabolism were altered significantly by the fermentation process. Although the fermented metabolites were not tested using in vivo studies to increase human health benefits, our findings provide an insight into the alteration of metabolites induced by fermentation, and indicated that the metabolomic analysis for the process should be accompanied by fermenting strains and conditions. PMID:28704842

Evaluation of Ultrasonic Fiber Structure Extraction Technique Using Autopsy Specimens of Liver

NASA Astrophysics Data System (ADS)

Yamaguchi, Tadashi; Hirai, Kazuki; Yamada, Hiroyuki; Ebara, Masaaki; Hachiya, Hiroyuki

2005-06-01

It is very important to diagnose liver cirrhosis noninvasively and correctly. In our previous studies, we proposed a processing technique to detect changes in liver tissue in vivo. In this paper, we propose the evaluation of the relationship between liver disease and echo information using autopsy specimens of a human liver in vitro. It is possible to verify the function of a processing parameter clearly and to compare the processing result and the actual human liver tissue structure by in vitro experiment. In the results of our processing technique, information that did not obey a Rayleigh distribution from the echo signal of the autopsy liver specimens was extracted depending on changes in a particular processing parameter. The fiber tissue structure of the same specimen was extracted from a number of histological images of stained tissue. We constructed 3D structures using the information extracted from the echo signal and the fiber structure of the stained tissue and compared the two. By comparing the 3D structures, it is possible to evaluate the relationship between the information that does not obey a Rayleigh distribution of the echo signal and the fibrosis structure.

Analysis of metabolomic profile of fermented Orostachys japonicus A. Berger by capillary electrophoresis time of flight mass spectrometry.

PubMed

Das, Gitishree; Patra, Jayanta Kumar; Lee, Sun-Young; Kim, Changgeon; Park, Jae Gyu; Baek, Kwang-Hyun

2017-01-01

Microbial cell performance in food biotechnological processes has become an important concern for improving human health worldwide. Lactobacillus plantarum, which is widely distributed in nature, is a lactic acid bacterium with many industrial applications for fermented foods or functional foods (e.g., probiotics). In the present study, using capillary electrophoresis time of flight mass spectrometry, the metabolomic profile of dried Orostachys japonicus A. Berger, a perennial medicinal herb with L. plantarum was compared with that of O. japonicus fermented with L. plantarum to elucidate the metabolomic changes induced by the fermentation process. The levels of several metabolites were changed by the fermentation process, indicating their involvement in microbial performance. For example, glycolysis, the pentose phosphate pathway, the TCA cycle, the urea cycle-related metabolism, nucleotide metabolism, and lipid and amino acid metabolism were altered significantly by the fermentation process. Although the fermented metabolites were not tested using in vivo studies to increase human health benefits, our findings provide an insight into the alteration of metabolites induced by fermentation, and indicated that the metabolomic analysis for the process should be accompanied by fermenting strains and conditions.

The Human Dimension of Systemic Department-Level Change: A Change Agent's Retrospective on a Case of Reform

ERIC Educational Resources Information Center

Vanasupa, Linda

2011-01-01

This paper represents a narrative of the process of department-level reform through the eyes of the initiating agent of change. Over the course of reform, our program has grown by 40%, primarily through retaining students. We exhibit a 10% net important rate of engineering students in the first two years of the curriculum relative to the college's…

Characterization of the Epigenetic Changes During Human Gonadal Primordial Germ Cells Reprogramming.

PubMed

Eguizabal, C; Herrera, L; De Oñate, L; Montserrat, N; Hajkova, P; Izpisua Belmonte, J C

2016-09-01

Epigenetic reprogramming is a central process during mammalian germline development. Genome-wide DNA demethylation in primordial germ cells (PGCs) is a prerequisite for the erasure of epigenetic memory, preventing the transmission of epimutations to the next generation. Apart from DNA demethylation, germline reprogramming has been shown to entail reprogramming of histone marks and chromatin remodelling. Contrary to other animal models, there is limited information about the epigenetic dynamics during early germ cell development in humans. Here, we provide further characterization of the epigenetic configuration of the early human gonadal PGCs. We show that early gonadal human PGCs are DNA hypomethylated and their chromatin is characterized by low H3K9me2 and high H3K27me3 marks. Similarly to previous observations in mice, human gonadal PGCs undergo dynamic chromatin changes concomitant with the erasure of genomic imprints. Interestingly, and contrary to mouse early germ cells, expression of BLIMP1/PRDM1 persists in through all gestational stages in human gonadal PGCs and is associated with nuclear lysine-specific demethylase-1. Our work provides important additional information regarding the chromatin changes associated with human PGCs development between 6 and 13 weeks of gestation in male and female gonads. Stem Cells 2016;34:2418-2428. © 2016 AlphaMed Press.

Amphetamine sensitization alters reward processing in the human striatum and amygdala.

PubMed

O'Daly, Owen G; Joyce, Daniel; Tracy, Derek K; Azim, Adnan; Stephan, Klaas E; Murray, Robin M; Shergill, Sukhwinder S

2014-01-01

Dysregulation of mesolimbic dopamine transmission is implicated in a number of psychiatric illnesses characterised by disruption of reward processing and goal-directed behaviour, including schizophrenia, drug addiction and impulse control disorders associated with chronic use of dopamine agonists. Amphetamine sensitization (AS) has been proposed to model the development of this aberrant dopamine signalling and the subsequent dysregulation of incentive motivational processes. However, in humans the effects of AS on the dopamine-sensitive neural circuitry associated with reward processing remains unclear. Here we describe the effects of acute amphetamine administration, following a sensitising dosage regime, on blood oxygen level dependent (BOLD) signal in dopaminoceptive brain regions during a rewarded gambling task performed by healthy volunteers. Using a randomised, double-blind, parallel-groups design, we found clear evidence for sensitization to the subjective effects of the drug, while rewarded reaction times were unchanged. Repeated amphetamine exposure was associated with reduced dorsal striatal BOLD signal during decision making, but enhanced ventromedial caudate activity during reward anticipation. The amygdala BOLD response to reward outcomes was blunted following repeated amphetamine exposure. Positive correlations between subjective sensitization and changes in anticipation- and outcome-related BOLD signal were seen for the caudate nucleus and amygdala, respectively. These data show for the first time in humans that AS changes the functional impact of acute stimulant exposure on the processing of reward-related information within dopaminoceptive regions. Our findings accord with pathophysiological models which implicate aberrant dopaminergic modulation of striatal and amygdala activity in psychosis and drug-related compulsive disorders.

Sustainability. Planetary boundaries: guiding human development on a changing planet.

PubMed

Steffen, Will; Richardson, Katherine; Rockström, Johan; Cornell, Sarah E; Fetzer, Ingo; Bennett, Elena M; Biggs, Reinette; Carpenter, Stephen R; de Vries, Wim; de Wit, Cynthia A; Folke, Carl; Gerten, Dieter; Heinke, Jens; Mace, Georgina M; Persson, Linn M; Ramanathan, Veerabhadran; Reyers, Belinda; Sörlin, Sverker

2015-02-13

The planetary boundaries framework defines a safe operating space for humanity based on the intrinsic biophysical processes that regulate the stability of the Earth system. Here, we revise and update the planetary boundary framework, with a focus on the underpinning biophysical science, based on targeted input from expert research communities and on more general scientific advances over the past 5 years. Several of the boundaries now have a two-tier approach, reflecting the importance of cross-scale interactions and the regional-level heterogeneity of the processes that underpin the boundaries. Two core boundaries—climate change and biosphere integrity—have been identified, each of which has the potential on its own to drive the Earth system into a new state should they be substantially and persistently transgressed. Copyright © 2015, American Association for the Advancement of Science.

Onset of alveolar recirculation in the developing lungs and its consequence on nanoparticle deposition in the pulmonary acinus

PubMed Central

Henry, Frank S.

2015-01-01

The structure of the gas exchange region of the human lung (the pulmonary acinus) undergoes profound change in the first few years of life. In this paper, we investigate numerically how the change in alveolar shape with time affects the rate of nanoparticle deposition deep in the lung during postnatal development. As human infant data is unavailable, we use a rat model of lung development. The process of postnatal lung development in the rat is remarkably similar to that of the human, and the structure of the rat acinus is indistinguishable from that of the human acinus. The current numerical predictions support our group's recent in vivo findings, which were also obtained by using growing rat lung models, that nanoparticle deposition in infants is strongly affected by the change in the structure of the pulmonary acinus. In humans, this major structural change occurs over the first 2 yr of life. Our current predictions would suggest that human infants at the age of ∼2 yr might be most at risk to the harmful effects of air pollution. Our results also suggest that dose estimates for inhalation therapies using nanoparticles, based on fully developed adult lungs with simple body weight scaling, are likely to overestimate deposition by up to 55% for newborns and underestimate deposition by up to 17% for 2-yr-old infants. PMID:26494453

The pro-life argument from substantial identity and the pro-choice argument from asymmetric value: a reply to Patrick Lee.

PubMed

Reiman, Jeffrey

2007-07-01

Lee claims that foetuses and adult humans are phases of the same identical substance, and thus have the same moral status because: first, foetuses and adults are the same physical organism, and second, the development from foetus to adult is quantitative and thus not a change of substance. Versus the first argument, I contend that the fact that foetuses and adults are the same physical organism implies only that they are the same thing but not the same substance, much as living adults and their corpses are the same thing (same body) but not the same substance. Against Lee's second argument, I contend that Lee confuses the nature of a process with the nature of its result. A process of quantitative change can produce a change in substance. Lee also fails to show that foetuses are rational and thus have all the essential properties of adults, as required for them to be the same substance. Against the pro-choice argument from asymmetric value (that only the fact that a human has become conscious of its life and begun to count on its continuing can explain human life's asymmetric moral value, i.e. that it is vastly worse to kill a human than not to produce one), Lee claims that foetus's lives are asymmetrically valuable to them before consciousness. This leads to counterintuitive outcomes, and it confuses the goodness of life (a symmetric value that cannot account for why it is worse to kill a human than not produce one) with asymmetric value.

Stem Cells: A Renaissance in Human Biology Research.

PubMed

Wu, Jun; Izpisua Belmonte, Juan Carlos

2016-06-16

The understanding of human biology and how it relates to that of other species represents an ancient quest. Limited access to human material, particularly during early development, has restricted researchers to only scratching the surface of this inherently challenging subject. Recent technological innovations, such as single cell "omics" and human stem cell derivation, have now greatly accelerated our ability to gain insights into uniquely human biology. The opportunities afforded to delve molecularly into scarce material and to model human embryogenesis and pathophysiological processes are leading to new insights of human development and are changing our understanding of disease and choice of therapy options. Copyright © 2016 Elsevier Inc. All rights reserved.

Lack of correlation between phonetic magnetic mismatch field and plasma d-serine levels in humans.

PubMed

Suga, Motomu; Kawakubo, Yuki; Nishimura, Yukika; Hashimoto, Kenji; Yumoto, Masato; Kasai, Kiyoto

2018-04-24

Uncovering molecular bases for auditory language processing in the human brain is a fundamental scientific challenge. The power and latency of the magnetic mismatch field (MMF) elicited by phoneme change, which are magnetoencephalographic indices of language function in its early stage of information processing, are theoretically thought to be modulated by N-methyl-d-aspartate-type glutamate receptor (NMDAR) function, but no study has yet assessed this possibility. We have thus sought to demonstrate an association between phonetic MMF power/latency and levels of plasma d-serine, an intrinsic co-agonist of glycine binding sites on NMDAR, in adults. The MMF response to phoneme changes was recorded using 204-channel magnetoencephalography in 61 healthy, right-handed, Japanese adults. Plasma levels of d- and l-serine were measured for each participant. We did not find a significant correlation between MMF power/latency and plasma serine levels. Despite a sufficient sample size, we failed to find an association between the physiological markers of the early stage of information processing of language in the auditory cortex and biomarkers indexing glutamatergic function. Our study did not indicate that a molecular index of glutamatergic function could be a surrogate marker for the early stage of information processing of language in humans. Copyright © 2018 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.

A proven knowledge-based approach to prioritizing process information

NASA Technical Reports Server (NTRS)

Corsberg, Daniel R.

1991-01-01

Many space-related processes are highly complex systems subject to sudden, major transients. In any complex process control system, a critical aspect is rapid analysis of the changing process information. During a disturbance, this task can overwhelm humans as well as computers. Humans deal with this by applying heuristics in determining significant information. A simple, knowledge-based approach to prioritizing information is described. The approach models those heuristics that humans would use in similar circumstances. The approach described has received two patents and was implemented in the Alarm Filtering System (AFS) at the Idaho National Engineering Laboratory (INEL). AFS was first developed for application in a nuclear reactor control room. It has since been used in chemical processing applications, where it has had a significant impact on control room environments. The approach uses knowledge-based heuristics to analyze data from process instrumentation and respond to that data according to knowledge encapsulated in objects and rules. While AFS cannot perform the complete diagnosis and control task, it has proven to be extremely effective at filtering and prioritizing information. AFS was used for over two years as a first level of analysis for human diagnosticians. Given the approach's proven track record in a wide variety of practical applications, it should be useful in both ground- and space-based systems.

In a Time of Change: Integrating the Arts and Humanities with Climate Change Science in Alaska

NASA Astrophysics Data System (ADS)

Leigh, M.; Golux, S.; Franzen, K.

2011-12-01

The arts and humanities have a powerful capacity to create lines of communication between the public, policy and scientific spheres. A growing network of visual and performing artists, writers and scientists has been actively working together since 2007 to integrate scientific and artistic perspectives on climate change in interior Alaska. These efforts have involved field workshops and collaborative creative processes culminating in public performances and a visual art exhibit. The most recent multimedia event was entitled In a Time of Change: Envisioning the Future, and challenged artists and scientists to consider future scenarios of climate change. This event included a public performance featuring original theatre, modern dance, Alaska Native Dance, poetry and music that was presented concurrently with an art exhibit featuring original works by 24 Alaskan visual artists. A related effort targeted K12 students, through an early college course entitled Climate Change and Creative Expression, which was offered to high school students at a predominantly Alaska Native charter school and integrated climate change science, creative writing, theatre and dance. Our program at Bonanza Creek Long Term Ecological Research (LTER) site is just one of many successful efforts to integrate arts and humanities with science within and beyond the NSF LTER Program. The efforts of various LTER sites to engage the arts and humanities with science, the public and policymakers have successfully generated excitement, facilitated mutual understanding, and promoted meaningful dialogue on issues facing science and society. The future outlook for integration of arts and humanities with science appears promising, with increasing interest from artists, scientists and scientific funding agencies.

Darwinian perspectives on the evolution of human languages.

PubMed

Pagel, Mark

2017-02-01

Human languages evolve by a process of descent with modification in which parent languages give rise to daughter languages over time and in a manner that mimics the evolution of biological species. Descent with modification is just one of many parallels between biological and linguistic evolution that, taken together, offer up a Darwinian perspective on how languages evolve. Combined with statistical methods borrowed from evolutionary biology, this Darwinian perspective has brought new opportunities to the study of the evolution of human languages. These include the statistical inference of phylogenetic trees of languages, the study of how linguistic traits evolve over thousands of years of language change, the reconstruction of ancestral or proto-languages, and using language change to date historical events.

Forest responses to changing climate: lessons from the past and uncertainty for the future

Treesearch

Donald H. DeHayes; George L., Jr. Jacobson; Paul G. Schaberg; Bruce Bongarten; Louis Iverson; Ann C. Dieffenbacher-Krall

2000-01-01

The earth's climate has undergone dramatic and long-term changes through natural processes many millennia before humans influenced global climate. Considerable evidence indicates that increasing concentrations of carbon dioxide and other greenhouse gases in the earth's atmosphere will lead to near-term warming, perhaps as much as 2 to 4°C in...

Changes in Situation Models Modulate Processes of Event Perception in Audiovisual Narratives

ERIC Educational Resources Information Center

Huff, Markus; Meitz, Tino G. K.; Papenmeier, Frank

2014-01-01

Humans understand text and film by mentally representing their contents in situation models. These describe situations using dimensions like time, location, protagonist, and action. Changes in 1 or more dimensions (e.g., a new character enters the scene) cause discontinuities in the story line and are often perceived as boundaries between 2…

Changing with the climate

Treesearch

Rhonda Mazza

2008-01-01

Carbon is a naturally occurring compound, essential to life on this planet. We exhale it, while plants absorb it as part of the photosynthetic process. Human activities have altered the carbon balance, however, and as a result have triggered changes in climates around the world. By extracting and burning oil, coal, and natural gas, carbon that was locked in long-term...

Land Cover Change and Remote Sensing in the Classroom: An Exercise to Study Urban Growth

ERIC Educational Resources Information Center

Delahunty, Tina; Lewis-Gonzales, Sarah; Phelps, Jack; Sawicki, Ben; Roberts, Charles; Carpenter, Penny

2012-01-01

The processes and implications of urban growth are studied in a variety of disciplines as urban growth affects both the physical and human landscape. Remote sensing methods provide ways to visualize and mathematically represent urban growth; and resultant land cover change data enable both quantitative and qualitative analysis. This article helps…

Environmental Education and Education for Sustainability Projects: Inspiring and Facilitating Implementation

ERIC Educational Resources Information Center

Williams, Ashley

2010-01-01

Our world is faced with a vast array of environmental catastrophes ranging everywhere from climate change, to air and water pollution, to mass extinction of species which all threaten the environment and human existence. As of now, students are not being informed on the sustainability issues, or engaged in the change process at school. Rote…

Evaluations of alternative methods for monitoring and estimating responses of salmon productivity in the North Pacific to future climatic change and other processes: A simulation study

EPA Science Inventory

Estimation of the relative influence of climate change, compared to other human activities, on dynamics of Pacific salmon (Oncorhynchus spp.) populations can help management agencies take appropriate management actions. We used empirically based simulation modelling of 48 sockeye...

How to Quantify Human-environment Interactions in the Past: A Global Historical Land Use Data Set for the Holocene

NASA Astrophysics Data System (ADS)

Klein Goldewijk, K.

2015-12-01

Land use plays an important role in the climate system. Many ecosystem processes are directly or indirectly climate driven, and together with human driven land use changes, they determine how the land surface will evolve through time. To assess the effects of land cover changes on the climate system, models are required which are capable of simulating interactions between the involved components of the Earth system. Since driving forces for global environmental change differ among regions, a geographically (spatially) explicit modeling approach is called for, so that it can be incorporated in global and regional (climate and/or biophysical) change models in order to enhance our understanding of the underlying processes and thus improving future projections.Some researchers suggest that mankind has shifted from living in the Holocene (~emergence of agriculture) into the Anthropocene (~humans capable of changing the Earth' atmosphere) since the start of the Industrial Revolution. But in the light of the sheer size and magnitude of some historical land use changes (e.g. the Black Plague in the 14th century and the aftermath of the Colombian Exchange in the 16th century), some believe that this point might have occurred earlier in time. There are still many uncertainties and gaps in our knowledge about the importance of land use (change) in the global biogeochemical cycle, and it is crucial that researchers from other disciplines are involved in decreasing the uncertainties.Thus, integrated records of the co-evolving human-environment system over millennia are needed to provide a basis for a deeper understanding of the present and for forecasting the future. This requires the major task of assembling and integrating regional and global historical, archaeological, and paleo-environmental records. Humans cannot predict the future. Here I present a tool for such long term global change studies; it is the latest update (v 3.2) of the History Database of the Global Environment (HYDE), which tries to incorporate many of these cross-disciplinary records and create thus new and more accurate estimates of the underlying demographic and agricultural driving factors for the whole Holocene. Estimates include population, cropland, pasture, rangeland, irrigation, rice, and built-up area.

The time course of attentional modulation on emotional conflict processing.

PubMed

Zhou, Pingyan; Yang, Guochun; Nan, Weizhi; Liu, Xun

2016-01-01

Cognitive conflict resolution is critical to human survival in a rapidly changing environment. However, emotional conflict processing seems to be particularly important for human interactions. This study examined whether the time course of attentional modulation on emotional conflict processing was different from cognitive conflict processing during a flanker task. Results showed that emotional N200 and P300 effects, similar to colour conflict processing, appeared only during the relevant task. However, the emotional N200 effect preceded the colour N200 effect, indicating that emotional conflict can be identified earlier than cognitive conflict. Additionally, a significant emotional N100 effect revealed that emotional valence differences could be perceived during early processing based on rough aspects of input. The present data suggest that emotional conflict processing is modulated by top-down attention, similar to cognitive conflict processing (reflected by N200 and P300 effects). However, emotional conflict processing seems to have more time advantages during two different processing stages.

Influence of Homogenization and Thermal Processing on the Gastrointestinal Fate of Bovine Milk Fat: In Vitro Digestion Study.

PubMed

Liang, Li; Qi, Ce; Wang, Xingguo; Jin, Qingzhe; McClements, David Julian

2017-12-20

Dairy lipids are an important source of energy and nutrients for infants and adults. The dimensions, aggregation state, and interfacial properties of fat globules in raw milk are changed by dairy processing operations, such as homogenization and thermal processing. These changes influence the behavior of fat globules within the human gastrointestinal tract (GIT). The gastrointestinal fate of raw milk, homogenized milk, high temperature short time (HTST) pasteurized milk, and ultrahigh temperature (UHT) pasteurized milk samples was therefore determined using a simulated GIT. The properties of particles in different regions of the GIT depended on the degree of milk processing. Homogenization increased the initial lipid digestion rate but did not influence the final digestion extent. Thermal processing of homogenized milk decreased the initial rate and final extent of lipid digestion, which was attributed to changes in interfacial structure. These results provide insights into the impact of dairy processing on the gastrointestinal fate of milk fat.

Perceptual and category processing of the Uncanny Valley hypothesis' dimension of human likeness: some methodological issues.

PubMed

Cheetham, Marcus; Jancke, Lutz

2013-06-03

Mori's Uncanny Valley Hypothesis(1,2) proposes that the perception of humanlike characters such as robots and, by extension, avatars (computer-generated characters) can evoke negative or positive affect (valence) depending on the object's degree of visual and behavioral realism along a dimension of human likeness (DHL) (Figure 1). But studies of affective valence of subjective responses to variously realistic non-human characters have produced inconsistent findings (3, 4, 5, 6). One of a number of reasons for this is that human likeness is not perceived as the hypothesis assumes. While the DHL can be defined following Mori's description as a smooth linear change in the degree of physical humanlike similarity, subjective perception of objects along the DHL can be understood in terms of the psychological effects of categorical perception (CP) (7). Further behavioral and neuroimaging investigations of category processing and CP along the DHL and of the potential influence of the dimension's underlying category structure on affective experience are needed. This protocol therefore focuses on the DHL and allows examination of CP. Based on the protocol presented in the video as an example, issues surrounding the methodology in the protocol and the use in "uncanny" research of stimuli drawn from morph continua to represent the DHL are discussed in the article that accompanies the video. The use of neuroimaging and morph stimuli to represent the DHL in order to disentangle brain regions neurally responsive to physical human-like similarity from those responsive to category change and category processing is briefly illustrated.

Perceptual and Category Processing of the Uncanny Valley Hypothesis' Dimension of Human Likeness: Some Methodological Issues

PubMed Central

Cheetham, Marcus; Jancke, Lutz

2013-01-01

Mori's Uncanny Valley Hypothesis1,2 proposes that the perception of humanlike characters such as robots and, by extension, avatars (computer-generated characters) can evoke negative or positive affect (valence) depending on the object's degree of visual and behavioral realism along a dimension of human likeness (DHL) (Figure 1). But studies of affective valence of subjective responses to variously realistic non-human characters have produced inconsistent findings 3, 4, 5, 6. One of a number of reasons for this is that human likeness is not perceived as the hypothesis assumes. While the DHL can be defined following Mori's description as a smooth linear change in the degree of physical humanlike similarity, subjective perception of objects along the DHL can be understood in terms of the psychological effects of categorical perception (CP) 7. Further behavioral and neuroimaging investigations of category processing and CP along the DHL and of the potential influence of the dimension's underlying category structure on affective experience are needed. This protocol therefore focuses on the DHL and allows examination of CP. Based on the protocol presented in the video as an example, issues surrounding the methodology in the protocol and the use in "uncanny" research of stimuli drawn from morph continua to represent the DHL are discussed in the article that accompanies the video. The use of neuroimaging and morph stimuli to represent the DHL in order to disentangle brain regions neurally responsive to physical human-like similarity from those responsive to category change and category processing is briefly illustrated. PMID:23770728

Cryptic genetic variation, evolution's hidden substrate

PubMed Central

Paaby, Annalise B.; Rockman, Matthew V.

2016-01-01

Cryptic genetic variation is invisible under normal conditions but fuel for evolution when circumstances change. In theory, CGV can represent a massive cache of adaptive potential or a pool of deleterious alleles in need of constant suppression. CGV emerges from both neutral and selective processes and it may inform how human populations respond to change. In experimental settings, CGV facilitates adaptation, but does it play an important role in the real world? We review the empirical support for widespread CGV in natural populations, including its potential role in emerging human diseases and the growing evidence of its contribution to evolution. PMID:24614309

Characterization of human cervical remodeling throughout pregnancy using in vivo Raman spectroscopy

NASA Astrophysics Data System (ADS)

O'Brien, Christine M.; Vargis, Elizabeth; Slaughter, Chris; Rudin, Amy P.; Herington, Jennifer L.; Bennett, Kelly A.; Reese, Jeff; Mahadevan-Jansen, Anita

2015-02-01

Globally, fifteen million babies are born preterm each year, affecting 1 in 8 pregnancies in the US alone. Cervical remodeling includes a biochemical cascade of changes that ultimately result in the thinning and dilation of the cervix for passage of a fetus. This process is poorly understood and is the focus of this study. Our group is utilizing Raman spectroscopy to evaluate biochemical changes occurring in the human cervix throughout pregnancy. This technique has high molecular specificity and can be performed in vivo, with the potential to unveil new molecular dynamics essential for cervical remodeling.

Teaching Climate Change Using System Models: An Understanding Global Change Project Pilot Study

NASA Astrophysics Data System (ADS)

Bean, J. R.; Stuhlsatz, M.; Bracey, Z. B.; Marshall, C. R.

2017-12-01

Teaching and learning about historical and anthropogenic climate change in the classroom requires integrating instructional resources that address physical, chemical, and biological processes. The Understanding Global Change (UGC) framework and system models developed at the University of California Museum of Paleontology (UCMP) provide visualizations of the relationships and feedbacks between Earth system processes, and the consequences of anthropogenic activities on global climate. This schema provides a mechanism for developing pedagogic narratives that are known to support comprehension and retention of information and relationships. We designed a nine-day instructional unit for middle and high school students that includes a sequence of hands-on, inquiry-based, data rich activities combined with conceptual modeling exercises intended to foster students' development of systems thinking and their understanding of human influences on Earth system processes. The pilot unit, Sea Level Rise in the San Francisco Bay Area, addresses the human causes and consequences of sea level rise and related Earth system processes (i.e., the water cycle and greenhouse effect). Most of the content is not Bay Area specific, and could be used to explore sea level rise in any coastal region. Students completed pre and post assessments, which included questions about the connectedness of components of the Earth system and probed their attitudes towards participating in environmental stewardship activities. Students sequentially drew models representing the content explored in the activities and wrote short descriptions of their system diagrams that were collected by teachers for analysis. We also randomly assigned classes to engage in a very short additional intervention that asked students to think about the role that humans play in the Earth system and to draw themselves into the models. The study will determine if these students have higher stewardship scores and more frequently discuss their personal impact on the Earth system in their writing tasks. The results from this pilot will inform the design of future resources using UGC system models.

The Changing Model of Soil

NASA Astrophysics Data System (ADS)

Richter, D. D.; Yaalon, D.

2012-12-01

The contemporary genetic model of soil is changing rapidly in response to advances in soil science and to human and environmental forcings in the 21st century (Richter and Yaalon, 2012). Three ongoing changes in the model of soil include that: (1) lower soil boundaries are much deeper than the solum, historically the O to B horizons, (2) most soils are polygenetic paleosols, products of soil-forming processes that have ranged widely over soils' lifetimes, and (3) soils are globally human-natural bodies, no longer natural bodies. Together, these changes in the model of soil mean that human forcings are a global wave of soil polygenesis altering fluxes of matter and energy and transforming soil thermodynamics as potentially very deep systems. Because soils are non-linear systems resulting from high-order interactions of physics, chemistry, and biology, trajectories of how human forcings alter soils over decades are not readily predictable and require long-term soil observations. There is much to learn about how soils are changing internally as central components of management systems and externally in relation to wider environments. To be critical, research has been remarkably superficial in studies of soil, reductionist in approach, and lacking in time-series observations of responses to soil management. While this criticism may sound negative, it creates significant opportunities for contemporary soil scientists.

Base changes in tumour DNA have the power to reveal the causes and evolution of cancer

DOE PAGES

Hollstein, M.; Alexandrov, L. B.; Wild, C. P.; ...

2016-06-06

Next-generation sequencing (NGS) technology has demonstrated that the cancer genomes are peppered with mutations. Although most somatic tumour mutations are unlikely to have any role in the cancer process per se, the spectra of DNA sequence changes in tumour mutation catalogues have the potential to identify the mutagens, and to reveal the mutagenic processes responsible for human cancer. Very recently, a novel approach for data mining of the vast compilations of tumour NGS data succeeded in separating and precisely defining at least 30 distinct patterns of sequence change hidden in mutation databases. At least half of these mutational signatures canmore » be readily assigned to known human carcinogenic exposures or endogenous mechanisms of mutagenesis. A quantum leap in our knowledge of mutagenesis in human cancers has resulted, stimulating a flurry of research activity. We trace here the major findings leading first to the hypothesis that carcinogenic insults leave characteristic imprints on the DNA sequence of tumours, and culminating in empirical evidence from NGS data that well-defined carcinogen mutational signatures are indeed present in tumour genomic DNA from a variety of cancer types. The notion that tumour DNAs can divulge environmental sources of mutation is now a well-accepted fact. This approach to cancer aetiology has also incriminated various endogenous, enzyme-driven processes that increase the somatic mutation load in sporadic cancers. The tasks now confronting the field of molecular epidemiology are to assign mutagenic processes to orphan and newly discovered tumour mutation patterns, and to determine whether avoidable cancer risk factors influence signatures produced by endogenous enzymatic mechanisms. As a result, innovative research with experimental models and exploitation of the geographical heterogeneity in cancer incidence can address these challenges.« less

Base changes in tumour DNA have the power to reveal the causes and evolution of cancer

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hollstein, M.; Alexandrov, L. B.; Wild, C. P.

Next-generation sequencing (NGS) technology has demonstrated that the cancer genomes are peppered with mutations. Although most somatic tumour mutations are unlikely to have any role in the cancer process per se, the spectra of DNA sequence changes in tumour mutation catalogues have the potential to identify the mutagens, and to reveal the mutagenic processes responsible for human cancer. Very recently, a novel approach for data mining of the vast compilations of tumour NGS data succeeded in separating and precisely defining at least 30 distinct patterns of sequence change hidden in mutation databases. At least half of these mutational signatures canmore » be readily assigned to known human carcinogenic exposures or endogenous mechanisms of mutagenesis. A quantum leap in our knowledge of mutagenesis in human cancers has resulted, stimulating a flurry of research activity. We trace here the major findings leading first to the hypothesis that carcinogenic insults leave characteristic imprints on the DNA sequence of tumours, and culminating in empirical evidence from NGS data that well-defined carcinogen mutational signatures are indeed present in tumour genomic DNA from a variety of cancer types. The notion that tumour DNAs can divulge environmental sources of mutation is now a well-accepted fact. This approach to cancer aetiology has also incriminated various endogenous, enzyme-driven processes that increase the somatic mutation load in sporadic cancers. The tasks now confronting the field of molecular epidemiology are to assign mutagenic processes to orphan and newly discovered tumour mutation patterns, and to determine whether avoidable cancer risk factors influence signatures produced by endogenous enzymatic mechanisms. As a result, innovative research with experimental models and exploitation of the geographical heterogeneity in cancer incidence can address these challenges.« less

Flaws in the Flow: The Weakness of Unstructured Business Process Modeling Languages Dealing with Data

NASA Astrophysics Data System (ADS)

Combi, Carlo; Gambini, Mauro

Process-Aware Information Systems (PAISs) need more flexibility for supporting complex and varying human activities. PAISs usually support business process design by means of graphical graph-oriented business process modeling languages (BPMLs) in conjunction with textual executable specifications. In this paper we discuss the flexibility of such BPMLs which are the main interface for users that need to change the behavior of PAISs. In particular, we show how common BPMLs features, that seem good when considered alone, have a negative impact on flexibility when they are combined together for providing a complete executable specification. A model has to be understood before being changed and a change is made only when the benefits outweigh the effort. Two main factors have a great impact on comprehensibility and ease of change: concurrency and modularity. We show why BPMLs usually offer a limited concurrency model and lack of modularity; finally we discuss how to overcome these problems.

Performance of a process-based hydrodynamic model in predicting shoreline change

NASA Astrophysics Data System (ADS)

Safak, I.; Warner, J. C.; List, J. H.

2012-12-01

Shoreline change is controlled by a complex combination of processes that include waves, currents, sediment characteristics and availability, geologic framework, human interventions, and sea level rise. A comprehensive data set of shoreline position (14 shorelines between 1978-2002) along the continuous and relatively non-interrupted North Carolina Coast from Oregon Inlet to Cape Hatteras (65 km) reveals a spatial pattern of alternating erosion and accretion, with an erosional average shoreline change rate of -1.6 m/yr and up to -8 m/yr in some locations. This data set gives a unique opportunity to study long-term shoreline change in an area hit by frequent storm events while relatively uninfluenced by human interventions and the effects of tidal inlets. Accurate predictions of long-term shoreline change may require a model that accurately resolves surf zone processes and sediment transport patterns. Conventional methods for predicting shoreline change such as one-line models and regression of shoreline positions have been designed for computational efficiency. These methods, however, not only have several underlying restrictions (validity for small angle of wave approach, assuming bottom contours and shoreline to be parallel, depth of closure, etc.) but also their empirical estimates of sediment transport rates in the surf zone have been shown to vary greatly from the calculations of process-based hydrodynamic models. We focus on hind-casting long-term shoreline change using components of the process-based, three-dimensional coupled-ocean-atmosphere-wave-sediment transport modeling system (COAWST). COAWST is forced with historical predictions of atmospheric and oceanographic data from public-domain global models. Through a method of coupled concurrent grid-refinement approach in COAWST, the finest grid with resolution of O(10 m) that covers the surf zone along the section of interest is forced at its spatial boundaries with waves and currents computed on the grids that cover the U.S. East Coast with resolutions as low as O(1 km). The computed patterns of the gradients of surf-zone integrated longshore sediment transport rates are compared with the observed shoreline change.

Innovation leadership: new perspectives for new work.

PubMed

Malloch, Kathy

2010-03-01

The industrial age command and control leadership style and supporting infrastructure are ineffective in meeting the challenges of the increased availability and sharing of information, the media used for knowledge transfer, the changing range and types of relationships between individuals, and the time required to transfer and share information. What has not changed is the need for effective personal relationships in the evaluation and selection of new technologies; human to human sensitivity, acknowledgment, and respect for the patient care experience. As individuals embrace these new technologies, the essence of the innovation leader emerges to purposefully guide, assess, integrate, and synthesize technology into the human work of patient care. Building organizational infrastructures with openness for technology and innovations to enhance effective patient care relationships now requires an innovation skill set that understands and integrates human needs with the best of technology. In this article a brief description of innovation leadership is presented as the backdrop for change along with 4 significant changes in work processes that have irreversibly altered health care work, the trimodal organizational structure to accommodate operations, innovation, and transition between the 2, and finally, individual and team behaviors that emphasize the work of innovation. Copyright 2010 Elsevier Inc. All rights reserved.

Roughing in Human Replumbing of the Water Cycle: Challenges, Opportunities, and Progress in Capturing the Influence of Water Management in Regional Models of Hydrology and Climate

NASA Astrophysics Data System (ADS)

Flores, A. N.; Kaiser, K. E.; Steimke, A.; Leonard, A.; FitzGerald, K.; Benner, S. G.; Vache, K. B.; Hillis, V.; Bolte, J.; Han, B.

2017-12-01

Humans exert tremendous influence on the redistribution of water in space and time. Humans have developed substantial infrastructure to provide water in adequate quantity and quality for production of food and energy, while seeking to maintain landscape processes and properties giving rise to ecosystem services on which humans rely (even when and if they are not well understood). Cyber-physical infrastructure includes dams, distributary canal networks, ditches to manage return flow, and networks of sensors to monitor environmental conditions. Social infrastructure includes legal frameworks for water rights, governance networks, and land management policies aimed at maintaining water quality. Changes in regional climate, land use and its intensity, and land cover in source areas exert pressures on this infrastructure, requiring models to characterize system-wide vulnerability and resilience. Here we present a synthesis of several ongoing and completed studies aimed at advancing our fundamental understanding of and ability to numerically model a system in which biophysical and human components cannot be separated. These studies are set within the Boise and Snake River Basin in the US Pacific Northwest and are organized around the aims of: (1) developing improved understanding and models of the ways that humans interact with each other and with biophysical processes at a range of spatiotemporal scales, and (2) using those models to predict how changes in climate and societal drivers, including in-migration and shifts in agricultural practices, will impact regional hydroclimate and associated ecosystem services. Key findings indicate differential pressures on water availability based on water rights seniority within the Lower Boise River basin under historical conditions, the potential for significantly earlier curtailment of water rights in future decades, and potential changes in agricultural practices in anticipation of future climate changes. This ongoing suite of projects illustrate significant improvements in modeling human modification of the timing and partitioning of hydrologic fluxes. Important challenges and opportunities remain, however, particularly in improving modeling the interactions between and among actors that exert controls on the redistribution of water.

42 CFR 82.32 - How will NIOSH make changes in scientific elements underlying the dose reconstruction process...

Code of Federal Regulations, 2010 CFR

2010-10-01

... PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES METHODS FOR CONDUCTING DOSE RECONSTRUCTION UNDER THE ENERGY EMPLOYEES...

Quantitative Proteomic Profiling of Low-Dose Ionizing Radiation Effects in a Human Skin Model

PubMed Central

Hengel, Shawna M.; Aldrich, Joshua T.; Waters, Katrina M.; Pasa-Tolic, Ljiljana; Stenoien, David L.

2014-01-01

To assess responses to low-dose ionizing radiation (LD-IR) exposures potentially encountered during medical diagnostic procedures, nuclear accidents or terrorist acts, a quantitative proteomic approach was used to identify changes in protein abundance in a reconstituted human skin tissue model treated with 0.1 Gy of ionizing radiation. To improve the dynamic range of the assay, subcellular fractionation was employed to remove highly abundant structural proteins and to provide insight into radiation-induced alterations in protein localization. Relative peptide quantification across cellular fractions, control and irradiated samples was performing using 8-plex iTRAQ labeling followed by online two-dimensional nano-scale liquid chromatography and high resolution MS/MS analysis. A total of 107 proteins were detected with statistically significant radiation-induced change in abundance (>1.5 fold) and/or subcellular localization compared to controls. The top biological pathways identified using bioinformatics include organ development, anatomical structure formation and the regulation of actin cytoskeleton. From the proteomic data, a change in proteolytic processing and subcellular localization of the skin barrier protein, filaggrin, was identified, and the results were confirmed by western blotting. This data indicate post-transcriptional regulation of protein abundance, localization and proteolytic processing playing an important role in regulating radiation response in human tissues. PMID:28250387

Climate-driven increase of natural wetland methane emissions offset by human-induced wetland reduction in China over the past three decades

USGS Publications Warehouse

Zhu, Qiuan; Peng, Changhui; Liu, Jinxun; Jiang, Hong; Fang, Xiuqin; Chen, Huai; Niu, Zhichun; Gong, Peng; Lin, Guanghui; Wang, Meng; Yang, Yanzheng; Chang, Jie; Ge, Ying; Xiang, Wenhua; Deng, Xiangwen; He, Jin-Sheng

2016-01-01

Both anthropogenic activities and climate change can affect the biogeochemical processes of natural wetland methanogenesis. Quantifying possible impacts of changing climate and wetland area on wetland methane (CH4) emissions in China is important for improving our knowledge on CH4 budgets locally and globally. However, their respective and combined effects are uncertain. We incorporated changes in wetland area derived from remote sensing into a dynamic CH4 model to quantify the human and climate change induced contributions to natural wetland CH4 emissions in China over the past three decades. Here we found that human-induced wetland loss contributed 34.3% to the CH4 emissions reduction (0.92 TgCH4), and climate change contributed 20.4% to the CH4 emissions increase (0.31 TgCH4), suggesting that decreasing CH4 emissions due to human-induced wetland reductions has offset the increasing climate-driven CH4 emissions. With climate change only, temperature was a dominant controlling factor for wetland CH4 emissions in the northeast (high latitude) and Qinghai-Tibet Plateau (high altitude) regions, whereas precipitation had a considerable influence in relative arid north China. The inevitable uncertainties caused by the asynchronous for different regions or periods due to inter-annual or seasonal variations among remote sensing images should be considered in the wetland CH4 emissions estimation.

Understanding The Individual Impacts Of Human Interventions And Climate Change On Hydrologic Variables In India

NASA Astrophysics Data System (ADS)

Sharma, T.; Chhabra, S., Jr.; Karmakar, S.; Ghosh, S.

2015-12-01

We have quantified the historical climate change and Land Use Land Cover (LULC) change impacts on the hydrologic variables of Indian subcontinent by using Variable Infiltration Capacity (VIC) mesoscale model at 0.5° spatial resolution and daily temporal resolution. The results indicate that the climate change in India has predominating effects on the basic water balance components such as water yield, evapotranspiration and soil moisture. This analysis is with the assumption of naturalised hydrologic cycle, i.e., the impacts of human interventions like construction of controlled (primarily dams, diversions and reservoirs) and water withdrawals structures are not taken into account. The assumption is unrealistic since there are numerous anthropogenic disturbances which result in large changes on vegetation composition and distribution patterns. These activities can directly or indirectly influence the dynamics of water cycle; subsequently affecting the hydrologic processes like plant transpiration, infiltration, evaporation, runoff and sublimation. Here, we have quantified the human interventions by using the reservoir and irrigation module of VIC model which incorporates the irrigation schemes, reservoir characteristics and water withdrawals. The impact of human interventions on hydrologic variables in many grids are found more predominant than climate change and might be detrimental to water resources at regional level. This spatial pattern of impacts will facilitate water manager and planners to design and station hydrologic structures for a sustainable water resources management.

Climate-driven increase of natural wetland methane emissions offset by human-induced wetland reduction in China over the past three decades

PubMed Central

Zhu, Qiuan; Peng, Changhui; Liu, Jinxun; Jiang, Hong; Fang, Xiuqin; Chen, Huai; Niu, Zhenguo; Gong, Peng; Lin, Guanghui; Wang, Meng; Wang, Han; Yang, Yanzheng; Chang, Jie; Ge, Ying; Xiang, Wenhua; Deng, Xiangwen; He, Jin-Sheng

2016-01-01

Both anthropogenic activities and climate change can affect the biogeochemical processes of natural wetland methanogenesis. Quantifying possible impacts of changing climate and wetland area on wetland methane (CH4) emissions in China is important for improving our knowledge on CH4 budgets locally and globally. However, their respective and combined effects are uncertain. We incorporated changes in wetland area derived from remote sensing into a dynamic CH4 model to quantify the human and climate change induced contributions to natural wetland CH4 emissions in China over the past three decades. Here we found that human-induced wetland loss contributed 34.3% to the CH4 emissions reduction (0.92 TgCH4), and climate change contributed 20.4% to the CH4 emissions increase (0.31 TgCH4), suggesting that decreasing CH4 emissions due to human-induced wetland reductions has offset the increasing climate-driven CH4 emissions. With climate change only, temperature was a dominant controlling factor for wetland CH4 emissions in the northeast (high latitude) and Qinghai-Tibet Plateau (high altitude) regions, whereas precipitation had a considerable influence in relative arid north China. The inevitable uncertainties caused by the asynchronous for different regions or periods due to inter-annual or seasonal variations among remote sensing images should be considered in the wetland CH4 emissions estimation. PMID:27892535

Exploring Land Use and Land Cover Change and Feedbacks in the Global Change Assessment Model

NASA Astrophysics Data System (ADS)

Chen, M.; Vernon, C. R.; Huang, M.; Calvin, K. V.; Le Page, Y.; Kraucunas, I.

2017-12-01

Land Use and Land Cover Change (LULCC) is a major driver of global and regional environmental change. Projections of land use change are thus an essential component in Integrated Assessment Models (IAMs) to study feedbacks between transformation of energy systems and land productivity under the context of climate change. However, the spatial scale of IAMs, e.g., the Global Change Assessment Model (GCAM), is typically larger than the scale of terrestrial processes in the human-Earth system, LULCC downscaling therefore becomes a critical linkage among these multi-scale and multi-sector processes. Parametric uncertainties in LULCC downscaling algorithms, however, have been under explored, especially in the context of how such uncertainties could propagate to affect energy systems in a changing climate. In this study, we use a LULCC downscaling model, Demeter, to downscale GCAM-based future land use scenarios into fine spatial scales, and explore the sensitivity of downscaled land allocations to key parameters. Land productivity estimates (e.g., biomass production and crop yield) based on the downscaled LULCC scenarios are then fed to GCAM to evaluate how energy systems might change due to altered water and carbon cycle dynamics and their interactions with the human system, , which would in turn affect future land use projections. We demonstrate that uncertainties in LULCC downscaling can result in significant differences in simulated scenarios, indicating the importance of quantifying parametric uncertainties in LULCC downscaling models for integrated assessment studies.

Building social cognitive models of language change.

PubMed

Hruschka, Daniel J; Christiansen, Morten H; Blythe, Richard A; Croft, William; Heggarty, Paul; Mufwene, Salikoko S; Pierrehumbert, Janet B; Poplack, Shana

2009-11-01

Studies of language change have begun to contribute to answering several pressing questions in cognitive sciences, including the origins of human language capacity, the social construction of cognition and the mechanisms underlying culture change in general. Here, we describe recent advances within a new emerging framework for the study of language change, one that models such change as an evolutionary process among competing linguistic variants. We argue that a crucial and unifying element of this framework is the use of probabilistic, data-driven models both to infer change and to compare competing claims about social and cognitive influences on language change.

Development of an integrated, zero-G pneumatic transporter/rotating-paddle incinerator/catalytic afterburner subsystem for processing human waste on board spacecraft

NASA Technical Reports Server (NTRS)

Fields, S. F.; Labak, L. J.; Honegger, R. J.

1974-01-01

A baseline laboratory prototype of an integrated, six man, zero-g subsystem for processing human wastes onboard spacecraft was investigated, and included the development of an operational specification for the baseline subsystem, followed by design and fabrication. The program was concluded by performing a series of six tests over a period of two weeks to evaluate the performance of the subsystem. The results of the tests were satisfactory, however, several changes in the design of the subsystem are required before completely satisfactory performance can be achieved.

Give Design a Chance: A Case for a Human Centered Approach to Operational Art

DTIC Science & Technology

2017-03-30

strategy development and operational art. This demands fuller integration of the Army Design Methodology (ADM) and the Military Decision Making Process...MDMP). This monograph proposes a way of thinking and planning that goes beyond current Army doctrinal methodologies to address the changing...between conceptual and detailed planning. 15. SUBJECT TERMS Design; Army Design Methodology (ADM); Human Centered; Strategy; Operational Art

Toward a Psychology of Human Agency: Pathways and Reflections.

PubMed

Bandura, Albert

2018-03-01

Social cognitive theory is founded on an agentic perspective. This article reviews the core features of human agency and the individual, proxy, and collective forms in which it is exercised. Agency operates through a triadic codetermination process of causation. Knowledge from this line of theorizing is widely applied to effect individual and social change, including worldwide applications that address some of the most urgent global problems.

The Transmission of Environmental Values from Sources of Influence to Young Adults: Toward an Understanding of the Process Leading to Environmental Values Internalization

ERIC Educational Resources Information Center

Depper, Gina L.

2017-01-01

The world faces significant environmental challenges due largely to unsustainable human behavior. Values have been found to be a direct and indirect predictor of human behavior and understanding how they are formed/influenced is critical to any strategy of behavioral change. Our understanding of how environmental values are transmitted and…

Managing changes in distributed biomedical ontologies using hierarchical distributed graph transformation.

PubMed

Shaban-Nejad, Arash; Haarslev, Volker

2015-01-01

The issue of ontology evolution and change management is inadequately addressed by available tools and algorithms, mostly due to the lack of suitable knowledge representation formalisms to deal with temporal abstract notations and the overreliance on human factors. Also most of the current approaches have been focused on changes within the internal structure of ontologies and interactions with other existing ontologies have been widely neglected. In our research, after revealing and classifying some of the common alterations in a number of popular biomedical ontologies, we present a novel agent-based framework, Represent, Legitimate and Reproduce (RLR), to semi-automatically manage the evolution of bio-ontologies, with emphasis on the FungalWeb Ontology, with minimal human intervention. RLR assists and guides ontology engineers through the change management process in general and aids in tracking and representing the changes, particularly through the use of category theory and hierarchical graph transformation.

Understanding bladder management on a palliative care unit: a grounded theory study.

PubMed

Gutmanis, Iris; Hay, Melissa; Shadd, Joshua; Byrne, Janette; McCallum, Sarah; Bishop, Kristen; Whitfield, Patricia; Faulds, Cathy

2017-03-16

Research regarding factors associated with nursing-initiated changes to bladder management at end-of-life is sparse. To explore the process of Palliative Care Unit (PCU) nurses' approach to bladder management changes. Nursing staff from one PCU in London, Canada were interviewed regarding bladder management care practices. A constructivist grounded theory was generated. Four interconnected themes emerged: humanity (compassionate support of patients); journey (making the most of a finite timeline); health condition (illness, functional decline); and context (orders, policies, supplies). These overlapping themes must be considered in light of ongoing changes which prompt recycling through the framework. While bladder management necessitates shared decision-making and individualised care, nurses' phronetic experience may serve to detect the presence of change and the need to consider other alternatives. End-of-life bladder management requires nurses to continually reconsider the significance of humanity, journey, health condition and context in light of ongoing changes.

Glial cell morphological and density changes through the lifespan of rhesus macaques.

PubMed

Robillard, Katelyn N; Lee, Kim M; Chiu, Kevin B; MacLean, Andrew G

2016-07-01

How aging impacts the central nervous system (CNS) is an area of intense interest. Glial morphology is known to affect neuronal and immune function as well as metabolic and homeostatic balance. Activation of glia, both astrocytes and microglia, occurs at several stages during development and aging. The present study analyzed changes in glial morphology and density through the entire lifespan of rhesus macaques, which are physiologically and anatomically similar to humans. We observed apparent increases in gray matter astrocytic process length and process complexity as rhesus macaques matured from juveniles through adulthood. These changes were not attributed to cell enlargement because they were not accompanied by proportional changes in soma or process volume. There was a decrease in white matter microglial process length as rhesus macaques aged. Aging was shown to have a significant effect on gray matter microglial density, with a significant increase in aged macaques compared with adults. Overall, we observed significant changes in glial morphology as macaques age indicative of astrocytic activation with subsequent increase in microglial density in aged macaques. Copyright © 2016 Elsevier Inc. All rights reserved.

Quantitative EEG analysis in minimally conscious state patients during postural changes.

PubMed

Greco, A; Carboncini, M C; Virgillito, A; Lanata, A; Valenza, G; Scilingo, E P

2013-01-01

Mobilization and postural changes of patients with cognitive impairment are standard clinical practices useful for both psychic and physical rehabilitation process. During this process, several physiological signals, such as Electroen-cephalogram (EEG), Electrocardiogram (ECG), Photopletysmography (PPG), Respiration activity (RESP), Electrodermal activity (EDA), are monitored and processed. In this paper we investigated how quantitative EEG (qEEG) changes with postural modifications in minimally conscious state patients. This study is quite novel and no similar experimental data can be found in the current literature, therefore, although results are very encouraging, a quantitative analysis of the cortical area activated in such postural changes still needs to be deeply investigated. More specifically, this paper shows EEG power spectra and brain symmetry index modifications during a verticalization procedure, from 0 to 60 degrees, of three patients in Minimally Consciousness State (MCS) with focused region of impairment. Experimental results show a significant increase of the power in β band (12 - 30 Hz), commonly associated to human alertness process, thus suggesting that mobilization and postural changes can have beneficial effects in MCS patients.

Ambiguous meanings of projects as facilitators of sensegiving.

PubMed

Lunkka, Nina; Suhonen, Marjo

2015-10-01

To describe mid-level nurse managers' experiences of sensegiving in the context of hospital projects. Sensegiving is about shaping and affecting how employees see themselves, their work and issues related to their work. It has been little studied in the context of hospital projects from mid-level nurse managers' point of view. Mid-level nurse managers (n = 10) were interviewed about their experiences of projects from the viewpoint of sensegiving during change processes. Data was analysed using discourse analysis. Three repertoires were constructed from the data: the repertoires of regeneration, control and humane. Projects were considered as appropriate ways for sensegiving in hospitals from the viewpoint of mid-level nurse managers. In order to use projects effectively in hospitals as means for change management mid-level nurse managers ought to enhance their role as interpreters during the change process (i.e. strengthen their visioning, talk and dialogue skills). Training on the nature of change as a social and interactive process could deepen mid-level nurse managers' understanding of the change process in the context of hospital projects. © 2014 John Wiley & Sons Ltd.

Automated Processing of 2-D Gel Electrophoretograms of Genomic DNA for Hunting Pathogenic DNA Molecular Changes.

PubMed

Takahashi; Nakazawa; Watanabe; Konagaya

1999-01-01

We have developed the automated processing algorithms for 2-dimensional (2-D) electrophoretograms of genomic DNA based on RLGS (Restriction Landmark Genomic Scanning) method, which scans the restriction enzyme recognition sites as the landmark and maps them onto a 2-D electrophoresis gel. Our powerful processing algorithms realize the automated spot recognition from RLGS electrophoretograms and the automated comparison of a huge number of such images. In the final stage of the automated processing, a master spot pattern, on which all the spots in the RLGS images are mapped at once, can be obtained. The spot pattern variations which seemed to be specific to the pathogenic DNA molecular changes can be easily detected by simply looking over the master spot pattern. When we applied our algorithms to the analysis of 33 RLGS images derived from human colon tissues, we successfully detected several colon tumor specific spot pattern changes.

Testing pigeon memory in a change detection task.

PubMed

Wright, Anthony A; Katz, Jeffrey S; Magnotti, John; Elmore, L Caitlin; Babb, Stephanie; Alwin, Sarah

2010-04-01

Six pigeons were trained in a change detection task with four colors. They were shown two colored circles on a sample array, followed by a test array with the color of one circle changed. The pigeons learned to choose the changed color and transferred their performance to four unfamiliar colors, suggesting that they had learned a generalized concept of color change. They also transferred performance to test delays several times their 50-msec training delay without prior delay training. The accurate delay performance of several seconds suggests that their change detection was memory based, as opposed to a perceptual attentional capture process. These experiments are the first to show that an animal species (pigeons, in this case) can learn a change detection task identical to ones used to test human memory, thereby providing the possibility of directly comparing short-term memory processing across species.

Semi-quantitative proteomics of mammalian cells upon short-term exposure to non-ionizing electromagnetic fields.

PubMed

Kuzniar, Arnold; Laffeber, Charlie; Eppink, Berina; Bezstarosti, Karel; Dekkers, Dick; Woelders, Henri; Zwamborn, A Peter M; Demmers, Jeroen; Lebbink, Joyce H G; Kanaar, Roland

2017-01-01

The potential effects of non-ionizing electromagnetic fields (EMFs), such as those emitted by power-lines (in extremely low frequency range), mobile cellular systems and wireless networking devices (in radio frequency range) on human health have been intensively researched and debated. However, how exposure to these EMFs may lead to biological changes underlying possible health effects is still unclear. To reveal EMF-induced molecular changes, unbiased experiments (without a priori focusing on specific biological processes) with sensitive readouts are required. We present the first proteome-wide semi-quantitative mass spectrometry analysis of human fibroblasts, osteosarcomas and mouse embryonic stem cells exposed to three types of non-ionizing EMFs (ELF 50 Hz, UMTS 2.1 GHz and WiFi 5.8 GHz). We performed controlled in vitro EMF exposures of metabolically labeled mammalian cells followed by reliable statistical analyses of differential protein- and pathway-level regulations using an array of established bioinformatics methods. Our results indicate that less than 1% of the quantitated human or mouse proteome responds to the EMFs by small changes in protein abundance. Further network-based analysis of the differentially regulated proteins did not detect significantly perturbed cellular processes or pathways in human and mouse cells in response to ELF, UMTS or WiFi exposure. In conclusion, our extensive bioinformatics analyses of semi-quantitative mass spectrometry data do not support the notion that the short-time exposures to non-ionizing EMFs have a consistent biologically significant bearing on mammalian cells in culture.

Semi-quantitative proteomics of mammalian cells upon short-term exposure to non-ionizing electromagnetic fields

PubMed Central

Laffeber, Charlie; Eppink, Berina; Bezstarosti, Karel; Dekkers, Dick; Woelders, Henri; Zwamborn, A. Peter M.; Demmers, Jeroen; Lebbink, Joyce H. G.; Kanaar, Roland

2017-01-01

The potential effects of non-ionizing electromagnetic fields (EMFs), such as those emitted by power-lines (in extremely low frequency range), mobile cellular systems and wireless networking devices (in radio frequency range) on human health have been intensively researched and debated. However, how exposure to these EMFs may lead to biological changes underlying possible health effects is still unclear. To reveal EMF-induced molecular changes, unbiased experiments (without a priori focusing on specific biological processes) with sensitive readouts are required. We present the first proteome-wide semi-quantitative mass spectrometry analysis of human fibroblasts, osteosarcomas and mouse embryonic stem cells exposed to three types of non-ionizing EMFs (ELF 50 Hz, UMTS 2.1 GHz and WiFi 5.8 GHz). We performed controlled in vitro EMF exposures of metabolically labeled mammalian cells followed by reliable statistical analyses of differential protein- and pathway-level regulations using an array of established bioinformatics methods. Our results indicate that less than 1% of the quantitated human or mouse proteome responds to the EMFs by small changes in protein abundance. Further network-based analysis of the differentially regulated proteins did not detect significantly perturbed cellular processes or pathways in human and mouse cells in response to ELF, UMTS or WiFi exposure. In conclusion, our extensive bioinformatics analyses of semi-quantitative mass spectrometry data do not support the notion that the short-time exposures to non-ionizing EMFs have a consistent biologically significant bearing on mammalian cells in culture. PMID:28234898

Contemplating Catastrophe: conveying the causes, effects, risks of and responses to global change

NASA Astrophysics Data System (ADS)

McCaffrey, M.; Berbeco, M.; Lahsen, M.

2013-12-01

Humans are changing nature and undermining the life supporting systems of the planet to an unprecedented extent, eroding more soil than all natural processes combined, fixing more nitrogen than all the bacteria on the planet, and substantially altering the land cover and chemistry of the atmosphere and waters. Yet, especially in the United States but also elsewhere, environmental awareness and policy action has been lackluster and hesitant due to a range of factors, including manufactured doubt and denial, psychological, cultural and economic investments in maintenance of status quo, and - when concern does exist - lack of knowledge about how to foster effective change. This paper will examine how recent research findings on human impacts on the planet are being conveyed to non-technical audiences and discuss challenges and opportunities to provide the public with the relevant knowledge and knowhow to address the risks of, and responses to global change. It will argue that a second-wave scientific literacy consisting in deeper understanding of the scientific process must be nurtured as part of a process to capacitate populations, especially youths, to navigate conflicting evidence and claims that surround many environmental threats. Such literacy must be fostered through 'learning conversations,' community and capacity-building, and integrated education, communication and outreach infusing science and solutions to foster a more effective approach to confronting potential catastrophe. 25 February 2013 at 16:30 Pacific Time

CEOS Theory: A Comprehensive Approach to Understanding Hard to Maintain Behaviour Change.

PubMed

Borland, Ron

2017-03-01

This paper provides a brief introduction to CEOS theory, a comprehensive theory for understanding hard to maintain behaviour change. The name CEOS is an acronym for Context, Executive, and Operational Systems theory. Behaviour is theorised to be the result of the moment by moment interaction between internal needs (operational processes) in relation to environmental conditions, and for humans this is augmented by goal-directed, executive action which can transcend immediate contingencies. All behaviour is generated by operational processes. Goal-directed behaviours only triumph over contingency-generated competing behaviours when operational processes have been sufficiently activated to support them. Affective force can be generated around executive system (ES) goals from such things as memories of direct experience, vicarious experience, and emotionally charged communications mediated through stories the person generates. This paper makes some refinements and elaborations of the theory, particularly around the role of feelings, and of the importance of stories and scripts for facilitating executive action. It also sketches out how it reconceptualises a range of issues relevant to behaviour change. CEOS provides a framework for understanding the limitations of both informational and environmental approaches to behaviour change, the need for self-regulatory strategies and for taking into account more basic aspects of human functioning. © 2016 The Authors. Applied Psychology: Health and Well-Being published by John Wiley & Sons Ltd on behalf of International Association of Applied Psychology.

Microenvironmental reprogramming by three-dimensional culture enables dermal papilla cells to induce de novo human hair-follicle growth

PubMed Central

Higgins, Claire A.; Chen, James C.; Cerise, Jane E.; Jahoda, Colin A. B.; Christiano, Angela M.

2013-01-01

De novo organ regeneration has been observed in several lower organisms, as well as rodents; however, demonstrating these regenerative properties in human cells and tissues has been challenging. In the hair follicle, rodent hair follicle-derived dermal cells can interact with local epithelia and induce de novo hair follicles in a variety of hairless recipient skin sites. However, multiple attempts to recapitulate this process in humans using human dermal papilla cells in human skin have failed, suggesting that human dermal papilla cells lose key inductive properties upon culture. Here, we performed global gene expression analysis of human dermal papilla cells in culture and discovered very rapid and profound molecular signature changes linking their transition from a 3D to a 2D environment with early loss of their hair-inducing capacity. We demonstrate that the intact dermal papilla transcriptional signature can be partially restored by growth of papilla cells in 3D spheroid cultures. This signature change translates to a partial restoration of inductive capability, and we show that human dermal papilla cells, when grown as spheroids, are capable of inducing de novo hair follicles in human skin. PMID:24145441

Enhanced Expression of Interferon-γ-Induced Antigen-Processing Machinery Components in a Spontaneously Occurring Cancer1

PubMed Central

Cerruti, Fulvia; Martano, Marina; Petterino, Claudio; Bollo, Enrico; Morello, Emanuela; Bruno, Renato; Buracco, Paolo; Cascio, Paolo

2007-01-01

In human tumors, changes in the surface expression and/or function of major histocompatibility complex (MHC) class I antigens are frequently found and may provide malignant cells with a mechanism to escape control of the immune system. This altered human lymphocyte antigen (HLA) class I phenotype can be caused by either structural alterations or dysregulation of genes encoding subunits of HLA class I antigens and/or components of the MHC class I antigen-processing machinery (APM). Herein we analyze the expression of several proteins involved in the generation of MHC class I epitopes in feline injection site sarcoma, a spontaneously occurring tumor in cats that is an informativemodel for the study of tumor biology in other species, including humans. Eighteen surgically removed primary fibrosarcoma lesions were analyzed, and an enhanced expression of two catalytic subunits of immunoproteasomes, PA28 and leucine aminopeptidase, was found in tumors compared to matched normal tissues. As a functional counterpart of these changes in protein levels, proteasomal activities were increased in tissue extracts from fibrosarcomas. Taken together, these results suggest that alterations in the APM system may account for reduced processing of selected tumor antigens and may potentially provide neoplastic fibroblasts with a mechanism for escape from T-cell recognition and destruction. PMID:18030364

Enhanced expression of interferon-gamma-induced antigen-processing machinery components in a spontaneously occurring cancer.

PubMed

Cerruti, Fulvia; Martano, Marina; Petterino, Claudio; Bollo, Enrico; Morello, Emanuela; Bruno, Renato; Buracco, Paolo; Cascio, Paolo

2007-11-01

In human tumors, changes in the surface expression and/or function of major histocompatibility complex (MHC) class I antigens are frequently found and may provide malignant cells with a mechanism to escape control of the immune system. This altered human lymphocyte antigen (HLA) class I phenotype can be caused by either structural alterations or dysregulation of genes encoding subunits of HLA class I antigens and/or components of the MHC class I antigen-processing machinery (APM). Herein we analyze the expression of several proteins involved in the generation of MHC class I epitopes in feline injection site sarcoma, a spontaneously occurring tumor in cats that is an informative model for the study of tumor biology in other species, including humans. Eighteen surgically removed primary fibrosarcoma lesions were analyzed, and an enhanced expression of two catalytic subunits of immunoproteasomes, PA28 and leucine aminopeptidase, was found in tumors compared to matched normal tissues. As a functional counterpart of these changes in protein levels, proteasomal activities were increased in tissue extracts from fibrosarcomas. Taken together, these results suggest that alterations in the APM system may account for reduced processing of selected tumor antigens and may potentially provide neoplastic fibroblasts with a mechanism for escape from T-cell recognition and destruction.

Effect of the bifurcation angle on the flow within a synthetic model of lower human airways

NASA Astrophysics Data System (ADS)

Espinosa Moreno, Andres Santiago; Duque Daza, Carlos Alberto

2016-11-01

The effect of the bifurcation angle on the flow pattern developed during respiratory inhalation and exhalation processes was explored numerically using a synthetic model of lower human airways featuring three generations of a dichotomous morphology as described by a Weibel model. Laminar flow simulations were performed for six bifurcation angles and four Reynolds numbers relevant to human respiratory flow. Numerical results of the inhalation process showed a peak displacement trend of the velocity profile towards the inner walls of the model. This displacement exhibited correlation with Dean-type secondary flow patterns, as well as with the onset and location of vortices. High wall shear stress regions on the inner walls were observed for a range of bifurcation angles. Noteworthy, specific bifurcation angles produced higher values of pressure drop, compared to the average behavior, as well as changes in the volumetric flow through the branches. Results of the simulations for exhalation process showed a different picture, mainly the appearance of symmetrical velocity profiles and the change of location of the regions of high wall shear stress. The use of this modelling methodology for biomedical applications is discussed considering the validity of the obtained results. Department of Mechanical and Mechatronics Engineering, Universidad Nacional de Colombia.

Mercury in tropical and subtropical coastal environments

PubMed Central

Costa, Monica F.; Landing, William M.; Kehrig, Helena A.; Barletta, Mário; Holmes, Christopher D.; Barrocas, Paulo R. G.; Evers, David C.; Buck, David G.; Vasconcellos, Ana Claudia; Hacon, Sandra S.; Moreira, Josino C.; Malm, Olaf

2012-01-01

Anthropogenic activities influence the biogeochemical cycles of mercury, both qualitatively and quantitatively, on a global scale from sources to sinks. Anthropogenic processes that alter the temporal and spatial patterns of sources and cycling processes are changing the impacts of mercury contamination on aquatic biota and humans. Human exposure to mercury is dominated by the consumption of fish and products from aquaculture operations. The risk to society and to ecosystems from mercury contamination is growing, and it is important to monitor these expanding risks. However, the extent and manner to which anthropogenic activities will alter mercury sources and biogeochemical cycling in tropical and sub-tropical coastal environments is poorly understood. Factors as (1) lack of reliable local/regional data; (2) rapidly changing environmental conditions; (3) governmental priorities and; (4) technical actions from supra-national institutions, are some of the obstacles to overcome in mercury cycling research and policy formulation. In the tropics and sub-tropics, research on mercury in the environment is moving from an exploratory “inventory” phase towards more process-oriented studies. Addressing biodiversity conservation and human health issues related to mercury contamination of river basins and tropical coastal environments are an integral part of paragraph 221 paragraph of the United Nations document “The Future We Want” issued in Rio de Janeiro in June 2012. PMID:22901765

Drought in a human-modified world: reframing drought definitions, understanding, and analysis approaches

NASA Astrophysics Data System (ADS)

Van Loon, Anne F.; Stahl, Kerstin; Di Baldassarre, Giuliano; Clark, Julian; Rangecroft, Sally; Wanders, Niko; Gleeson, Tom; Van Dijk, Albert I. J. M.; Tallaksen, Lena M.; Hannaford, Jamie; Uijlenhoet, Remko; Teuling, Adriaan J.; Hannah, David M.; Sheffield, Justin; Svoboda, Mark; Verbeiren, Boud; Wagener, Thorsten; Van Lanen, Henny A. J.

2016-09-01

In the current human-modified world, or Anthropocene, the state of water stores and fluxes has become dependent on human as well as natural processes. Water deficits (or droughts) are the result of a complex interaction between meteorological anomalies, land surface processes, and human inflows, outflows, and storage changes. Our current inability to adequately analyse and manage drought in many places points to gaps in our understanding and to inadequate data and tools. The Anthropocene requires a new framework for drought definitions and research. Drought definitions need to be revisited to explicitly include human processes driving and modifying soil moisture drought and hydrological drought development. We give recommendations for robust drought definitions to clarify timescales of drought and prevent confusion with related terms such as water scarcity and overexploitation. Additionally, our understanding and analysis of drought need to move from single driver to multiple drivers and from uni-directional to multi-directional. We identify research gaps and propose analysis approaches on (1) drivers, (2) modifiers, (3) impacts, (4) feedbacks, and (5) changing the baseline of drought in the Anthropocene. The most pressing research questions are related to the attribution of drought to its causes, to linking drought impacts to drought characteristics, and to societal adaptation and responses to drought. Example questions include

• (i) What are the dominant drivers of drought in different parts of the world? (ii) How do human modifications of drought enhance or alleviate drought severity? (iii) How do impacts of drought depend on the physical characteristics of drought vs. the vulnerability of people or the environment? (iv) To what extent are physical and human drought processes coupled, and can feedback loops be identified and altered to lessen or mitigate drought? (v) How should we adapt our drought analysis to accommodate changes in the normal situation (i.e. what are considered normal or reference conditions) over time?

Space Biophysics: Accomplishments, Trends, Challenges

NASA Technical Reports Server (NTRS)

Smith, Jeffrey D.

2015-01-01

Physics and biology are inextricably linked. All the chemical and biological processes of life are dutifully bound to follow the rules and laws of physics. In space, these physical laws seem to turn on their head and biological systems, from microbes to humans, adapt and evolve in myriad ways to cope with the changed physical influences of the space environment. Gravity is the most prominent change in space that influences biology. In microgravity, the physical processes of sedimentation, density-driven convective flow, influence of surface tension and fluid pressure profoundly influence biology at the molecular and cellular level as well as at the whole-body level. Gravity sensing mechanisms are altered, structural and functional components of biology (such as bone and muscle) are reduced and changes in the way fluids and gasses behave also drive the way microbial systems and biofilms grow as well as the way plants and animals adapt. The radiation environment also effects life in space. Solar particle events and high energy cosmic radiation can cause serious damage to DNA and other biomolecules. The results can cause mutation, cellular damage or death, leading to health consequences of acute radiation damage or long-term health consequences such as increased cancer risk. Space Biophysics is the study and utilization of physical changes in space that cause changes in biological systems. The unique physical environment in space has been used successfully to grow high-quality protein crystals and 3D tissue cultures that could not be grown in the presence of unidirectional gravitational acceleration here on Earth. All biological processes that change in space have their root in a biophysical alteration due to microgravity and/or the radiation environment of space. In order to fully-understand the risks to human health in space and to fully-understand how humans, plants, animals and microbes can safely and effectively travel and eventually live for long periods beyond the protective environment of Earth, the biophysical properties underlying these changes must be studied, characterized and understood. This lecture reviews the current state of NASA biophysics research accomplishments and identifies future trends and challenges for biophysics research on the International Space Station and beyond.

How does the anthropogenic activity affect the spring discharge?

NASA Astrophysics Data System (ADS)

Hao, Yonghong; Zhang, Juan; Wang, Jiaojiao; Li, Ruifang; Hao, Pengmei; Zhan, Hongbin

2016-09-01

Karst hydrological process has largely been altered by climate change and human activity. In many places throughout the world, human activity (e.g. groundwater pumping and dewatering from mining) has intensified and surpassed climate change, where human activity becomes the primary factor that affects groundwater system. But it is still largely unclear how the human activity affects spring discharge in magnitude and periodicity. This study investigates the effects of anthropogenic activity on spring discharge, using the Xin'an Springs of China as an example. The Xin'an Spring discharge were divided into two time periods: the pre-development period from 1956 to 1971 and the post-development period from 1972 to 2013. We confirm the dividing time (i.e. 1971) of these two periods using the Wilcoxon rank-sum test. Then the wavelet transform and wavelet coherence were used to analyze the karst hydrological processes for the two periods respectively. We analyze the correlations of precipitation and the Xin'an spring discharge with the monsoons including the Indian Summer Monsoon (ISM) and the West North Pacific Monsoon (WNPM) and the climate teleconnections including El Niño Southern Oscillation (ENSO) and Pacific Decadal Oscillation (PDO), respectively. The results indicated that the spring discharge was attenuated about 19.63% under the influence of human activity in the Xin'an Springs basin. However, human activity did not alter the size of the resonance frequencies between the spring discharge and the monsoons. In contrast, it reinforced the periodicities of the monsoons-driven spring discharge. It suggested that human has adapted to the major climate periodicities, and human activity had the same rhyme with the primary climate periodicity. In return, human activity enhances the correlation between the monsoons and the spring discharge.

Dystrophic microglia in the aging human brain.

PubMed

Streit, Wolfgang J; Sammons, Nicole W; Kuhns, Amanda J; Sparks, D Larry

2004-01-15

We have studied microglial morphology in the human cerebral cortex of two nondemented subjects using high-resolution LN-3 immunohistochemistry. Several abnormalities in microglial cytoplasmic structure, including deramification, spheroid formation, gnarling, and fragmentation of processes, were identified. These changes were determined to be different from the morphological changes that occur during microglial activation and they were designated collectively as microglial dystrophy. Quantitative evaluation of dystrophic changes in microglia revealed that these were much more prevalent in the older subject (68-year-old) than in the younger one (38-year-old). Thus, we conclude that microglial dystrophy is a sign of microglial cell senescence. We hypothesize that microglial senescence could be important for understanding age-related declines in cognitive function. Copyright 2003 Wiley-Liss, Inc.

[Advances in plant ecophysiological studies on re-vegetation of degraded ecosystem].

PubMed

Zhao, Ping

2003-11-01

Natural force and human intervention lead to many local, regional, and sometimes global changes in plant community patterns. Regardless of the cause and intensity of these changes, ecosystem can recover most of their attributes through natural succession, or can be repaired by human assistance. The essentiality of restoration of degraded ecosystem is community succession, a process during which an ecosystem evolves from primary stage to advanced stage, and its structure and function change from simple to complex plant. Ecophysiological study could explain some macroscopical phenomena of the ecology of re-vegetation of degraded ecosystem, and provide a scientific base for assembling pioneering plant community. The advances in plant ecophysiological study on re-vegetation of degraded ecosystems were reviewed in this paper.

Water-quality monitoring and process understanding in support of environmental policy and management

USGS Publications Warehouse

Peters, N.E.

2008-01-01

The quantity and quality of freshwater at any point on the landscape reflect the combined effects of many processes operating along hydrological pathways within a drainage basin/watershed/catchment. Primary drivers for the availability of water are landscape changes and patterns, and the processes affecting the timing, magnitude, and intensity of precipitation, including global climate change. The degradation of air, land, and water in one part of a drainage basin can have negative effects on users downstream; the time and space scales of the effects are determined by the residence time along the various hydrological pathways. Hydrology affects transport, deposition, and recycling of inorganic materials and sediment. These components affect biota and associated ecosystem processes, which rely on sustainable flows throughout a drainage basin. Human activities on all spatial scales affect both water quantity and quality, and some human activities can have a disproportionate effect on an entire drainage basin. Aquatic systems have been continuously modified by agriculture, through land-use change, irrigation and navigation, disposal of urban, mining, and industrial wastes, and engineering modifications to the environment. Interdisciplinary integrated basin studies within the last several decades have provided a more comprehensive understanding of the linkages among air, land, and water resources. This understanding, coupled with environmental monitoring, has evolved a more multidisciplinary integrated approach to resource management, particularly within drainage basins.

Do Quercus ilex woodlands undergo abrupt non-linear functional changes in response to human disturbance along a climatic gradient?

NASA Astrophysics Data System (ADS)

Bochet, Esther; García-Fayos, Patricio; José Molina, Maria; Moreno de las Heras, Mariano; Espigares, Tíscar; Nicolau, Jose Manuel; Monleon, Vicente

2017-04-01

Theoretical models predict that drylands are particularly prone to suffer critical transitions with abrupt non-linear changes in their structure and functions as a result of the existing complex interactions between climatic fluctuations and human disturbances. However, so far, few studies provide empirical data to validate these models. We aim at determining how holm oak (Quercus ilex) woodlands undergo changes in their functions in response to human disturbance along an aridity gradient (from semi-arid to sub-humid conditions), in eastern Spain. For that purpose, we used (a) remote-sensing estimations of precipitation-use-efficiency (PUE) from enhanced vegetation index (EVI) observations performed in 231x231 m plots of the Moderate Resolution Imaging Spectroradiometer (MODIS); (b) biological and chemical soil parameter determinations (extracellular soil enzyme activity, soil respiration, nutrient cycling processes) from soil sampled in the same plots; (c) vegetation parameter determinations (ratio of functional groups) from vegetation surveys performed in the same plots. We analyzed and compared the shape of the functional change (in terms of PUE and soil and vegetation parameters) in response to human disturbance intensity for our holm oak sites along the aridity gradient. Overall, our results evidenced important differences in the shape of the functional change in response to human disturbance between climatic conditions. Semi-arid areas experienced a more accelerated non-linear decrease with an increasing disturbance intensity than sub-humid ones. The proportion of functional groups (herbaceous vs. woody cover) played a relevant role in the shape of the functional response of the holm oak sites to human disturbance.

Multiscale Modeling of Human-Water Interactions: The Role of Time-Scales

NASA Astrophysics Data System (ADS)

Bloeschl, G.; Sivapalan, M.

2015-12-01

Much of the interest in hydrological modeling in the past decades revolved around resolving spatial variability. With the rapid changes brought about by human impacts on the hydrologic cycle, there is now an increasing need to refocus on time dependency. We present a co-evolutionary view of hydrologic systems, in which every part of the system including human systems, co-evolve, albeit at different rates. The resulting coupled human-nature system is framed as a dynamical system, characterized by interactions of fast and slow time scales and feedbacks between environmental and social processes. This gives rise to emergent phenomena such as the levee effect, adaptation to change and system collapse due to resource depletion. Changing human values play a key role in the emergence of these phenomena and should therefore be considered as internal to the system in a dynamic way. The co-evolutionary approach differs from the traditional view of water resource systems analysis as it allows for path dependence, multiple equilibria, lock-in situations and emergent phenomena. The approach may assist strategic water management for long time scales through facilitating stakeholder participation, exploring the possibility space of alternative futures, and helping to synthesise the observed dynamics of different case studies. Future research opportunities include the study of how changes in human values are connected to human-water interactions, historical analyses of trajectories of system co-evolution in individual places and comparative analyses of contrasting human-water systems in different climate and socio-economic settings. Reference Sivapalan, M. and G. Blöschl (2015) Time Scale Interactions and the Co-evolution of Humans and Water. Water Resour. Res., 51, in press.

DNA methylation and healthy human aging.

PubMed

Jones, Meaghan J; Goodman, Sarah J; Kobor, Michael S

2015-12-01

The process of aging results in a host of changes at the cellular and molecular levels, which include senescence, telomere shortening, and changes in gene expression. Epigenetic patterns also change over the lifespan, suggesting that epigenetic changes may constitute an important component of the aging process. The epigenetic mark that has been most highly studied is DNA methylation, the presence of methyl groups at CpG dinucleotides. These dinucleotides are often located near gene promoters and associate with gene expression levels. Early studies indicated that global levels of DNA methylation increase over the first few years of life and then decrease beginning in late adulthood. Recently, with the advent of microarray and next-generation sequencing technologies, increases in variability of DNA methylation with age have been observed, and a number of site-specific patterns have been identified. It has also been shown that certain CpG sites are highly associated with age, to the extent that prediction models using a small number of these sites can accurately predict the chronological age of the donor. Together, these observations point to the existence of two phenomena that both contribute to age-related DNA methylation changes: epigenetic drift and the epigenetic clock. In this review, we focus on healthy human aging throughout the lifetime and discuss the dynamics of DNA methylation as well as how interactions between the genome, environment, and the epigenome influence aging rates. We also discuss the impact of determining 'epigenetic age' for human health and outline some important caveats to existing and future studies. © 2015 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.

State of the Carbon Cycle - Consequences of Rising Atmospheric CO2

NASA Astrophysics Data System (ADS)

Moore, D. J.; Cooley, S. R.; Alin, S. R.; Brown, M. E.; Butman, D. E.; French, N. H. F.; Johnson, Z. I.; Keppel-Aleks, G.; Lohrenz, S. E.; Ocko, I.; Shadwick, E. H.; Sutton, A. J.; Potter, C. S.; Yu, R. M. S.

2016-12-01

The rise of atmospheric CO2, largely attributable to human activity through fossil fuel emissions and land-use change, has been dampened by carbon uptake by the ocean and terrestrial biosphere. We outline the consequences of this carbon uptake as direct and indirect effects on terrestrial and oceanic systems and processes for different regions of North America and the globe. We assess the capacity of these systems to continue to act as carbon sinks. Rising CO2 has decreased seawater pH; this process of ocean acidification has impacted some marine species and altered fundamental ecosystem processes with further effects likely. In terrestrial ecosystems, increased atmospheric CO2 causes enhanced photosynthesis, net primary production, and increased water-use efficiency. Rising CO2 may change vegetation composition and carbon storage, and widespread increases in water use efficiency likely influence terrestrial hydrology and biogeochemical cycling. Consequences for human populations include changes to ecosystem services including cultural activities surrounding land use, agricultural or harvesting practices. Commercial fish stocks have been impacted and crop production yields have been changed as a result of rising CO2. Ocean and terrestrial effects are contingent on, and feedback to, global climate change. Warming and modified precipitation regimes impact a variety of ecosystem processes, and the combination of climate change and rising CO2 contributes considerable uncertainty to forecasting carbon sink capacity in the ocean and on land. Disturbance regime (fire and insects) are modified with increased temperatures. Fire frequency and intensity increase, and insect lifecycles are disrupted as temperatures move out of historical norms. Changes in disturbance patterns modulate the effects of rising CO2 depending on ecosystem type, disturbance frequency, and magnitude of events. We discuss management strategies designed to limit the rise of atmospheric CO2 and reduce uncertainty in forecasts of decadal and centennial feedbacks of rising atmospheric CO2 on carbon storage.

State of the Carbon Cycle - Consequences of Rising Atmospheric CO2

NASA Technical Reports Server (NTRS)

Moore, David J.; Cooley, Sarah R.; Alin, Simone R.; Brown, Molly; Butman, David E.; French, Nancy H. F.; Johnson, Zackary I.; Keppel-Aleks; Lohrenz, Steven E.; Ocko, Ilissa;

From traditional to patient-centered learning: curriculum change as an intervention for changing institutional culture and promoting professionalism in undergraduate medical education.

PubMed

Christianson, Charles E; McBride, Rosanne B; Vari, Richard C; Olson, Linda; Wilson, H David

2007-11-01

The authors reframe a curriculum change from a traditional lecture-based to an integrated patient-centered approach as an intervention for changing the culture and hidden curriculum of an institution in ways that promote professionalism. Within this context, the authors articulate some of the inherent process and relational factors brought about by these curricular changes that are essential elements of this intervention process. In 1998 the University of North Dakota School of Medicine and Health Sciences (UNDSMHS) introduced a new preclinical patient-centered learning (PCL) curriculum for first- and second-year medical students. Case-based, small-group learning forms the critical foundation of the PCL process, and an integrated basic and clinical science didactic component supports this process. At the student level, the case-based PCL process generates innovative opportunities for professionalism education from the explicitly articulated formal content that arises naturally from the cases, but more importantly from the implicit values inherent to the PCL small-group process itself--humanism, accountability, pursuit of excellence, and altruism. Further, the organizational changes necessary for the transformation to the PCL curriculum required process changes at student, faculty, and administrative levels that have resulted in a cultural shift toward relationship centeredness within the institution. The authors describe the evolution and structure of the PCL curriculum at UNDSMHS and how this curricular transformation has served as an intervention that promotes professionalism and institutional culture change through (1) processes at the student level that present new opportunities for professionalism education, and (2) processes at student, faculty, administrative, and institutional levels that have created an institutional culture that supports, models, and promotes relationship-centered professional values.

Human Factors Principles in Information Dashboard Design

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hugo, Jacques V.; St. Germain, Shawn

When planning for control room upgrades, nuclear power plants have to deal with a multitude of engineering and operational impacts. This will inevitably include several human factors considerations, including physical ergonomics of workstations, viewing angles, lighting, seating, new communication requirements, and new concepts of operation. In helping nuclear power utilities to deal with these challenges, the Idaho National Laboratory (INL) has developed effective methods to manage the various phases of the upgrade life cycle. These methods focus on integrating human factors engineering processes with the plant’s systems engineering process, a large part of which is the development of end-state conceptsmore » for control room modernization. Such an end-state concept is a description of a set of required conditions that define the achievement of the plant’s objectives for the upgrade. Typically, the end-state concept describes the transition of a conventional control room, over time, to a facility that employs advanced digital automation technologies in a way that significantly improves system reliability, reduces human and control room-related hazards, reduces system and component obsolescence, and significantly improves operator performance. To make the various upgrade phases as concrete and as visible as possible, an end-state concept would include a set of visual representations of the control room before and after various upgrade phases to provide the context and a framework within which to consider the various options in the upgrade. This includes the various control systems, human-system interfaces to be replaced, and possible changes to operator workstations. This paper describes how this framework helps to ensure an integrated and cohesive outcome that is consistent with human factors engineering principles and also provide substantial improvement in operator performance. The paper further describes the application of this integrated approach in the strategic modernization program at a nuclear power plant where legacy systems are upgraded to advanced digital technologies through a systematic process that links human factors principles to the systems engineering process. This approach will help to create an integrated control room architecture beyond what is possible for individual subsystem upgrades alone. In addition, several human factors design and evaluation methods were used to develop the end-state concept, including interactive sessions with operators in INL’s Human System Simulation Laboratory, three-dimensional modeling to visualize control board changes.« less

Editorial for Journal of Hydrology: Regional Studies

USGS Publications Warehouse

Willems, Patrick; Batelaan, Okke; Hughes, Denis A.; Swarzenski, Peter W.

2014-01-01

Hydrological regimes and processes show strong regional differences. While some regions are affected by extreme drought and desertification, others are under threat of increased fluvial and/or pluvial floods. Changes to hydrological systems as a consequence of natural variations and human activities are region-specific. Many of these changes have significant interactions with and implications for human life and ecosystems. Amongst others, population growth, improvements in living standards and other demographic and socio-economic trends, related changes in water and energy demands, change in land use, water abstractions and returns to the hydrological system (UNEP, 2008), introduce temporal and spatial changes to the system and cause contamination of surface and ground waters. Hydro-meteorological boundary conditions are also undergoing spatial and temporal changes. Climate change has been shown to increase temporal and spatial variations of rainfall, increase temperature and cause changes to evapotranspiration and other hydro-meteorological variables (IPCC, 2013). However, these changes are also region specific. In addition to these climate trends, (multi)-decadal oscillatory changes in climatic conditions and large variations in meteorological conditions will continue to occur.

Transcriptome Network Analysis Reveals Aging-Related Mitochondrial and Proteasomal Dysfunction and Immune Activation in Human Thyroid

PubMed Central

Cho, Byuri Angela; Yoo, Seong-Keun; Song, Young Shin; Kim, Su-jin; Lee, Kyu Eun; Shong, Minho

2018-01-01

Background: Elucidating aging-related transcriptomic changes in human organs is necessary to understand the aging physiology and mechanisms, but little is known regarding the thyroid gland. We investigated aging-related transcriptomic alterations in the human thyroid gland and characterized the related molecular functions. Methods: Publicly available RNA sequencing data of 322 thyroid tissue samples from the Genotype-Tissue Expression project were analyzed. In addition, our own 64 RNA sequencing data of normal thyroid tissue samples were used as a validation set. To comprehensively evaluate the associations between aging and transcriptomic changes, we performed a weighted gene coexpression network analysis and pathway enrichment analysis. The thyroid differentiation score was then used for further analysis, defining the correlations between thyroid differentiation and aging. Results: The most significant aging-related transcriptomic change in thyroid was the downregulation of genes related to the mitochondrial and proteasomal functions (p = 3 × 10−6). Moreover, genes that are associated with immune processes were significantly upregulated with age (p = 3 × 10−4), and all of them overlapped with the upregulated genes in the thyroid glands affected by lymphocytic thyroiditis. Furthermore, these aging-related changes were not significantly different according to sex, but in terms of the thyroid differentiation, females were more susceptible to aging-related changes (p for trend = 0.03). Conclusions: Aging-related transcriptomic changes in the thyroid gland were associated with mitochondrial and proteasomal dysfunction, loss of differentiation, and activation of autoimmune processes. Our results provide clues to better understanding the age-related decline in thyroid function and higher susceptibility to autoimmune thyroid disease. PMID:29652618

Assessing hydrological effects of human interventions on coastal systems: numerical applications to the Venice Lagoon

NASA Astrophysics Data System (ADS)

Ferrarin, C.; Ghezzo, M.; Umgiesser, G.; Tagliapietra, D.; Camatti, E.; Zaggia, L.; Sarretta, A.

2013-05-01

The hydrological consequences of historical, contemporary and future human activities on a coastal system were investigated by means of numerical models. The changes in the morphology of the Lagoon of Venice during the last century result from the sedimentological response to the combined effects of human interventions on the environment and global changes. This study focuses on changes from 1927 to 2012 and includes the changes planned for the protection of the city of Venice from storm surges and exceptional tides under future sea level rise scenarios. The application of a hydrodynamic model allowed for the analysis of the morphological effects on the lagoon circulation, the interaction with the sea and the internal mixing processes. The absolute values of the exchange between the lagoon and sea increased from 1927 to 2002 (from 3900 to 4600 m3 s-1), while the daily fraction of lagoon water volume exchanged decreased. At the same time, the flattening of the lagoon and loss of morphological heterogeneity enhanced the internal mixing processes driven by the tide and wind, reducing thus the overall water renewal time from 11.9 days in 1927 to 10.8 days in 2002. Morphological changes during the last decade reduced the water exchange through the inlets and induced an increase of the basin-wide water renewal time of 0.5 day. In the future, Venice Lagoon will evolve to a more restricted environment due to sea level rise, which increases the lagoon volume, and periodical closure of the lagoon from the sea during flooding events, which reduces the communication with the open sea. Therefore, the flushing capacity of the lagoon will decrease considerably, especially in its central part. Furthermore, some considerations on the impact of the hydromorphological changes on the ecological dynamics are proposed.

Psychophysics and Neuronal Bases of Sound Localization in Humans

PubMed Central

Ahveninen, Jyrki; Kopco, Norbert; Jääskeläinen, Iiro P.

2013-01-01

Localization of sound sources is a considerable computational challenge for the human brain. Whereas the visual system can process basic spatial information in parallel, the auditory system lacks a straightforward correspondence between external spatial locations and sensory receptive fields. Consequently, the question how different acoustic features supporting spatial hearing are represented in the central nervous system is still open. Functional neuroimaging studies in humans have provided evidence for a posterior auditory “where” pathway that encompasses non-primary auditory cortex areas, including the planum temporale (PT) and posterior superior temporal gyrus (STG), which are strongly activated by horizontal sound direction changes, distance changes, and movement. However, these areas are also activated by a wide variety of other stimulus features, posing a challenge for the interpretation that the underlying areas are purely spatial. This review discusses behavioral and neuroimaging studies on sound localization, and some of the competing models of representation of auditory space in humans. PMID:23886698

[Human ecology. Which is the main challenge to Russia?].

PubMed

Velichkovskiĭ, B T

2002-01-01

The main direction in the study of human ecology in Russia today is to provide evidence for how to maintain environmental balance in the biosphere of the Earth, though the above factor also exerts a constantly growing negative impact on the health and life quality of the population. During the years of the reforms in the country, all the principal medical and demographic indices have undergone negative changes. To overcome the medicodemographic crisis should be now a priority problem to be solved in human ecology in Russia. The crisis was mainly caused by the "shock" strategy of the reforms. To eliminate the negative medicodemographic consequences, a strong working motivation should be firstly created for the population, that is to create such conditions that allow people to earn well-deserved living by honest work. All this requires the development of small business, democratization of private property forms of private property, and changes in the Government's policy concerning work payment. Medical scientists should clarify how biological mechanisms, that is negative social, economic and psychological factors, cause a drastic increase in mortality, particularly in the able-bodied population. This process is likely to involve three regulation levels; the central nervous system (dynamic stereotype break, as called by I. P. Pavlov), the neuroendocrine system (great stress, as described by G. Selye), molecular-cellular free radical processes (phenoptosis, as outlined by V. P. Skulachev). Five factors that most negatively affect human health and demographic processes were identified.

Integrating human and ecological risk assessment: application to the cyanobacterial harmful algal bloom problem.

PubMed

Orme-Zavaleta, Jennifer; Munns, Wayne R

2008-01-01

Environmental and public health policy continues to evolve in response to new and complex social, economic and environmental drivers. Globalization and centralization of commerce, evolving patterns of land use (e.g., urbanization, deforestation), and technological advances in such areas as manufacturing and development of genetically modified foods have created new and complex classes of stressors and risks (e.g., climate change, emergent and opportunist disease, sprawl, genomic change). In recognition of these changes, environmental risk assessment and its use are changing from stressor-endpoint specific assessments used in command and control types of decisions to an integrated approach for application in community-based decisions. As a result, the process of risk assessment and supporting risk analyses are evolving to characterize the human-environment relationship. Integrating risk paradigms combine the process of risk estimation for humans, biota, and natural resources into one assessment to improve the information used in environmental decisions (Suter et al. 2003b). A benefit to this approach includes a broader, system-wide evaluation that considers the interacting effects of stressors on humans and the environment, as well the interactions between these entities. To improve our understanding of the linkages within complex systems, risk assessors will need to rely on a suite of techniques for conducting rigorous analyses characterizing the exposure and effects relationships between stressors and biological receptors. Many of the analytical techniques routinely employed are narrowly focused and unable to address the complexities of an integrated assessment. In this paper, we describe an approach to integrated risk assessment, and discuss qualitative community modeling and Probabilistic Relational Modeling techniques that address these limitations and evaluate their potential for use in an integrated risk assessment of cyanobacteria.

Thermal processing of food reduces gut microbiota diversity of the host and triggers adaptation of the microbiota: evidence from two vertebrates.

PubMed

Zhang, Zhimin; Li, Dapeng

2018-05-31

Adoption of thermal processing of the diet drives human evolution and gut microbiota diversity changes in a dietary habit-dependent manner. However, whether thermal processing of food triggers gut microbial variation remains unknown. Herein, we compared the microbiota of non-thermally processed and thermally processed food (NF and TF) and investigated gut microbiota associated with NF and TF in catfish Silurus meridionalis and C57BL/6 mice to assess effects of thermal processing of food on gut microbiota and to further identify the differences in host responses. We found no differences in overall microbial composition and structure in the pairwise NF and TF, but identified differential microbial communities between food and gut. Both fish and mice fed TF had significantly lower gut microbial diversity than those fed NF. Moreover, thermal processing of food triggered the changes in their microbial communities. Comparative host studies further indicated host species determined gut microbial assemblies, even if fed with the same food. Fusobacteria was the most abundant phylum in the fish, and Bacteroidetes and Firmicutes dominated in the mice. Besides the consistent reduction of Bacteroidetes and the balanced Protebacteria, the response of other dominated gut microbiota in the fish and mice to TF was taxonomically opposite at the phylum level, and those further found at the genus level. Our results reveal that thermal processing of food strongly contributes to the reduction of gut microbial diversity and differentially drives microbial alterations in a host-dependent manner, suggesting specific adaptations of host-gut microbiota in vertebrates responding to thermal processing of food. These findings open a window of opportunity to understand the decline in gut microbial diversity and the community variation in human evolution and provide new insights into the host-specific microbial assemblages associated with the use of processing techniques in food preparation in humans and domesticated animals.

Ecosystem stressors in southern Nevada [Chapter 2] (Executive Summary)

Treesearch

Burton K. Pendleton; Jeanne C. Chambers; Matthew L. Brooks; Steven M. Ostoja

2013-01-01

Southern Nevada ecosystems are subject to a number of stressors that range in scope from local to regional to global. At the regional scale, human population growth and related activities constitute a major stressor. Nevada has undergone significant change due to unprecedented population growth and ongoing global change processes. Nevada’s growth rate has been the...

Human Dimensions of Global Environmental Change: Proposals for Research. Report of a Chinese-U.S. Workshop (May 12-16, 1988).

ERIC Educational Resources Information Center

1988

In 1986, the International Council fo Scientific Unions (ICSU) launched the International Geosphere-Biosphere Programme: A Study of Global Change (IGBP). The IGBP seeks to focus attention on the physical, chemical, and biological processes which contribute to understanding the components of the Earth as a system. The research topics presented in…

Introduction to the special section on alternative futures for Great Basin ecosystems

Treesearch

Erica Fleishman; Jeanne C. Chambers; Michael J. Wisdom

2009-01-01

Natural and anthropogenic processes are causing extensive and rapid ecological, social, and economic changes in arid and semiarid ecosystems worldwide. Nowhere are these changes more evident than in the Great Basin of the western United States, a region of 400,000 km2 that largely is managed by federal agencies. Major drivers of ecosystems and human demographics of the...

White Matter Maturation Supports the Development of Reasoning Ability through Its Influence on Processing Speed

ERIC Educational Resources Information Center

Ferrer, Emilio; Whitaker, Kirstie J.; Steele, Joel S.; Green, Chloe T.; Wendelken, Carter; Bunge, Silvia A.

2013-01-01

The structure of the human brain changes in several ways throughout childhood and adolescence. Perhaps the most salient of these changes is the strengthening of white matter tracts that enable distal brain regions to communicate with one another more quickly and efficiently. Here, we sought to understand whether and how white matter changes…

The footprints of visual attention in the Posner cueing paradigm revealed by classification images

NASA Technical Reports Server (NTRS)

Eckstein, Miguel P.; Shimozaki, Steven S.; Abbey, Craig K.

2002-01-01

In the Posner cueing paradigm, observers' performance in detecting a target is typically better in trials in which the target is present at the cued location than in trials in which the target appears at the uncued location. This effect can be explained in terms of a Bayesian observer where visual attention simply weights the information differently at the cued (attended) and uncued (unattended) locations without a change in the quality of processing at each location. Alternatively, it could also be explained in terms of visual attention changing the shape of the perceptual filter at the cued location. In this study, we use the classification image technique to compare the human perceptual filters at the cued and uncued locations in a contrast discrimination task. We did not find statistically significant differences between the shapes of the inferred perceptual filters across the two locations, nor did the observed differences account for the measured cueing effects in human observers. Instead, we found a difference in the magnitude of the classification images, supporting the idea that visual attention changes the weighting of information at the cued and uncued location, but does not change the quality of processing at each individual location.

Our Changing Planet: The FY 1993 US Global Change Research Program. A report by the Committee on Earth and Environmental Sciences, a supplement to the US President's fiscal year 1993 budget

NASA Technical Reports Server (NTRS)

1992-01-01

The U.S. Global Change Reasearch Program (USGCRP) was established as a Presidential initiative in the FY-1990 Budget to help develop sound national and international policies related to global environmental issues, particularly global climate change. The USGCRP is implemented through a priority-driven scientific research agenda that is designed to be integrated, comprehensive, and multidisciplinary. It is designed explicitly to address scientific uncertainties in such areas as climate change, ozone depletion, changes in terrestrial and marine productivity, global water and energy cycles, sea level changes, the impact of global changes on human health and activities, and the impact of anthropogenic activities on the Earth system. The USGCRP addresses three parallel but interconnected streams of activity: documenting global change (observations); enhancing understanding of key processes (process research); and predicting global and regional environmental change (integrated modeling and prediction).

Effects of geomagnetic activity variations on the physiological and psychological state of functionally healthy humans: Some results of Azerbaijani studies

NASA Astrophysics Data System (ADS)

Babayev, Elchin S.; Allahverdiyeva, Aysel A.

There are collaborative and cross-disciplinary space weather studies in the Azerbaijan National Academy of Sciences conducted with purposes of revealing possible effects of solar, geomagnetic and cosmic ray variability on certain technological, biological and ecological systems. This paper describes some results of the experimental studies of influence of the periodical and aperiodical changes of geomagnetic activity upon human brain, human health and psycho-emotional state. It also covers the conclusions of studies on influence of violent solar events and severe geomagnetic storms of the solar cycle 23 on the mentioned systems in middle-latitude location. It is experimentally established that weak and moderate geomagnetic storms do not cause significant changes in the brain's bioelectrical activity and exert only stimulating influence while severe disturbances of geomagnetic conditions cause negative influence, seriously disintegrate brain's functionality, activate braking processes and amplify the negative emotional background of an individual. It is concluded that geomagnetic disturbances affect mainly emotional and vegetative spheres of human beings while characteristics reflecting personality properties do not undergo significant changes.

Changes in human skull morphology across the agricultural transition are consistent with softer diets in preindustrial farming groups.

PubMed

Katz, David C; Grote, Mark N; Weaver, Timothy D

2017-08-22

Agricultural foods and technologies are thought to have eased the mechanical demands of diet-how often or how hard one had to chew-in human populations worldwide. Some evidence suggests correspondingly worldwide changes in skull shape and form across the agricultural transition, although these changes have proved difficult to characterize at a global scale. Here, adapting a quantitative genetics mixed model for complex phenotypes, we quantify the influence of diet on global human skull shape and form. We detect modest directional differences between foragers and farmers. The effects are consistent with softer diets in preindustrial farming groups and are most pronounced and reliably directional when the farming class is limited to dairying populations. Diet effect magnitudes are relatively small, affirming the primary role of neutral evolutionary processes-genetic drift, mutation, and gene flow structured by population history and migrations-in shaping diversity in the human skull. The results also bring an additional perspective to the paradox of why Homo sapiens , particularly agriculturalists, appear to be relatively well suited to efficient (high-leverage) chewing.

Variation in the loss of O6-methylguanine-DNA methyltransferase during immortalization of human fibroblasts.

PubMed

Green, M H; Karran, P; Lowe, J E; Priestley, A; Arlett, C F; Mayne, L

1990-01-01

We have examined O6-methylguanine-DNA methyltransferase (MT) activity in four human fibroblast cell lines during immortalization. Transfection of primary fibroblasts with the plasmid pSV3gpt or pSV3neo, which encode the SV40 large T antigen, confers a transformed phenotype but not immediate immortality. After a period of growth (pre-crisis) the cells enter a quiescent phase (crisis) from which an immortal clone of cells eventually grows out. From measurements of MT activity in extracts of cells taken at different defined stages of the immortalization process, we conclude that the establishment of a Mex- (MT-deficient) cell population is not specifically associated with cellular transformation or with any particular stage of immortalization. It appears that in different cell populations the change from Mex+ to Mex- may occur at different times during the immortalization process and that the change may be very abrupt.

Multiple Transient Signals in Human Visual Cortex Associated with an Elementary Decision

PubMed Central

Nolte, Guido

2017-01-01

The cerebral cortex continuously undergoes changes in its state, which are manifested in transient modulations of the cortical power spectrum. Cortical state changes also occur at full wakefulness and during rapid cognitive acts, such as perceptual decisions. Previous studies found a global modulation of beta-band (12–30 Hz) activity in human and monkey visual cortex during an elementary visual decision: reporting the appearance or disappearance of salient visual targets surrounded by a distractor. The previous studies disentangled neither the motor action associated with behavioral report nor other secondary processes, such as arousal, from perceptual decision processing per se. Here, we used magnetoencephalography in humans to pinpoint the factors underlying the beta-band modulation. We found that disappearances of a salient target were associated with beta-band suppression, and target reappearances with beta-band enhancement. This was true for both overt behavioral reports (immediate button presses) and silent counting of the perceptual events. This finding indicates that the beta-band modulation was unrelated to the execution of the motor act associated with a behavioral report of the perceptual decision. Further, changes in pupil-linked arousal, fixational eye movements, or gamma-band responses were not necessary for the beta-band modulation. Together, our results suggest that the beta-band modulation was a top-down signal associated with the process of converting graded perceptual signals into a categorical format underlying flexible behavior. This signal may have been fed back from brain regions involved in decision processing to visual cortex, thus enforcing a “decision-consistent” cortical state. SIGNIFICANCE STATEMENT Elementary visual decisions are associated with a rapid state change in visual cortex, indexed by a modulation of neural activity in the beta-frequency range. Such decisions are also followed by other events that might affect the state of visual cortex, including the motor command associated with the report of the decision, an increase in pupil-linked arousal, fixational eye movements, and fluctuations in bottom-up sensory processing. Here, we ruled out the necessity of these events for the beta-band modulation of visual cortex. We propose that the modulation reflects a decision-related state change, which is induced by the conversion of graded perceptual signals into a categorical format underlying behavior. The resulting decision signal may be fed back to visual cortex. PMID:28495972

Modelling human decision-making in coupled human and natural systems

NASA Astrophysics Data System (ADS)

Feola, G.

2012-12-01

A solid understanding of human decision-making is essential to analyze the complexity of coupled human and natural systems (CHANS) and inform policies to promote resilience in the face of environmental change. Human decisions drive and/or mediate the interactions and feedbacks, and contribute to the heterogeneity and non-linearity that characterize CHANS. However, human decision-making is usually over-simplistically modeled, whereby human agents are represented deterministically either as dumb or clairvoyant decision-makers. Decision-making models fall short in the integration of both environmental and human behavioral drivers, and concerning the latter, tend to focus on only one category, e.g. economic, cultural, or psychological. Furthermore, these models render a linear decision-making process and therefore fail to account for the recursive co-evolutionary dynamics in CHANS. As a result, these models constitute only a weak basis for policy-making. There is therefore scope and an urgent need for better approaches to human decision-making, to produce the knowledge that can inform vulnerability reduction policies in the face of environmental change. This presentation synthesizes the current state-of-the-art of modelling human decision-making in CHANS, with particular reference to agricultural systems, and delineates how the above mentioned shortcomings can be overcome. Through examples from research on pesticide use and adaptation to climate change, both based on the integrative agent-centered framework (Feola and Binder, 2010), the approach for an improved understanding of human agents in CHANS are illustrated. This entails: integrative approach, focus on behavioral dynamics more than states, feedbacks between individual and system levels, and openness to heterogeneity.

Co-evolutionary dynamics of the human-environment system in the Heihe River basin in the past 2000years.

PubMed

Lu, Zhixiang; Wei, Yongping; Feng, Qi; Xie, Jiali; Xiao, Honglang; Cheng, Guodong

2018-09-01

There is limited quantitative understanding of interactions between human and environmental systems over the millennial scale. We aim to reveal the co-evolutionary dynamics of the human-environment system in a river basin by simulating the water use and net primary production (NPP) allocation for human and environmental systems over the last 2000years in Heihe River basin (HRB) in northwest China. We partition the catchment total evapotranspiration (ET) into ET for human and environmental systems with a social-hydrological framework and estimate the NPP for human and environmental systems using the Box-Lieth model, then classify the co-evolutionary processes of the human-environment system into distinct phases using the rate of changes of NPP over time, and discover the trade-offs or synergies relationships between them based on the elasticity of change of the NPP for humans to the change of NPP for environment. The co-evolutionary dynamics of human-environment system in the HRB can be divided into four periods, including: Phase I (Han Dynasty-Yuan Dynasty): predevelopment characterized by nearly no trade-offs between human and environment; Phase II (Yuan Dynasty-RC): slow agricultural development: characterized by a small human win due to small trade-offs between human and environment; Phase III (RC-2000): rapid agricultural development: characterized by a large human win due to large trade-offs between human and environment, and Phase IV (2000-2010): a rebalance characterized by large human wins with a small-environment win due to synergies, although these occurred very occasionally. This study provides a quantitative approach to describe the co-evolution of the human-environment system from the perspective of trade-offs and synergies in the millennial scale for the first time. The relationships between humans and environment changed from trade-off to synergy with the implementation of the water reallocation scheme in 2000. These findings improve the understanding of how humans influence environmental systems and responses to environmental stresses. Copyright © 2018 Elsevier B.V. All rights reserved.

Protein oxidation and degradation during proliferative senescence of human MRC-5 fibroblasts.

PubMed

Sitte, N; Merker, K; von Zglinicki, T; Grune, T

2000-03-01

One of the highlights of age-related changes of cellular metabolism is the accumulation of oxidized proteins. The aging process on a cellular level can be treated either as the ongoing proliferation until a certain number of cell divisions is reached (the Hayflick limit) or as the aging of nondividing cells, that is, the age-related changes in cells without proliferation. The present investigation was undertaken to reveal the changes in protein turnover, proteasome activity, and protein oxidation status during proliferative senescence. We were able to demonstrate that the activity of the cytosolic proteasomal system declines dramatically during the proliferative senescence of human MRC-5 fibroblasts. Regardless of the loss in activity, it could be demonstrated that there are no changes in the transcription and translation of proteasomal subunits. This decline in proteasome activity was accompanied by an increased concentration of oxidized proteins. Cells at higher proliferation stages were no longer able to respond with increased degradation of endogenous [(35)S]-Met-radiolabeled proteins after hydrogen peroxide- or quinone-induced oxidative stress. It could be demonstrated that oxidized proteins in senescent human MRC-5 fibroblasts are not as quickly removed as they are in young cells. Therefore, our study demonstrates that the accumulation of oxidized proteins and decline in protein turnover and activity of the proteasomal system are not only a process of postmitotic aging but also occur during proliferative senescence and result in an increased half-life of oxidized proteins.

Detecting phenotype-driven transitions in regulatory network structure.

PubMed

Padi, Megha; Quackenbush, John

2018-01-01

Complex traits and diseases like human height or cancer are often not caused by a single mutation or genetic variant, but instead arise from functional changes in the underlying molecular network. Biological networks are known to be highly modular and contain dense "communities" of genes that carry out cellular processes, but these structures change between tissues, during development, and in disease. While many methods exist for inferring networks and analyzing their topologies separately, there is a lack of robust methods for quantifying differences in network structure. Here, we describe ALPACA (ALtered Partitions Across Community Architectures), a method for comparing two genome-scale networks derived from different phenotypic states to identify condition-specific modules. In simulations, ALPACA leads to more nuanced, sensitive, and robust module discovery than currently available network comparison methods. As an application, we use ALPACA to compare transcriptional networks in three contexts: angiogenic and non-angiogenic subtypes of ovarian cancer, human fibroblasts expressing transforming viral oncogenes, and sexual dimorphism in human breast tissue. In each case, ALPACA identifies modules enriched for processes relevant to the phenotype. For example, modules specific to angiogenic ovarian tumors are enriched for genes associated with blood vessel development, and modules found in female breast tissue are enriched for genes involved in estrogen receptor and ERK signaling. The functional relevance of these new modules suggests that not only can ALPACA identify structural changes in complex networks, but also that these changes may be relevant for characterizing biological phenotypes.

Process Consultancy. The Demand for Consultancy on Group Processes in the Open University--Implications of Change (Report No. 59). Process Consultancy within the Open University 1981-1991 (Report No. 61).

ERIC Educational Resources Information Center

Nicodemus, Robert

The two reports combined here provide introductory information on consultancy work at Great Britain's Open University Institution of Educational Technology. The approach at the institution was influenced by the theories and methods developed at the Tavistock Institute of Human Relations and applied to group relations training. It is noted that the…

Agile manufacturing: The factory of the future

NASA Technical Reports Server (NTRS)

Loibl, Joseph M.; Bossieux, Terry A.

1994-01-01

The factory of the future will require an operating methodology which effectively utilizes all of the elements of product design, manufacturing and delivery. The process must respond rapidly to changes in product demand, product mix, design changes or changes in the raw materials. To achieve agility in a manufacturing operation, the design and development of the manufacturing processes must focus on customer satisfaction. Achieving greatest results requires that the manufacturing process be considered from product concept through sales. This provides the best opportunity to build a quality product for the customer at a reasonable rate. The primary elements of a manufacturing system include people, equipment, materials, methods and the environment. The most significant and most agile element in any process is the human resource. Only with a highly trained, knowledgeable work force can the proper methods be applied to efficiently process materials with machinery which is predictable, reliable and flexible. This paper discusses the affect of each element on the development of agile manufacturing systems.

Interaction of preservation methods and radiation sterilization in human skin processing, with particular insight on the impact of the final water content and collagen disruption. Part I: process validation, water activity and collagen changes in tissues cryopreserved or processed using 50, 85 or 98% glycerol solutions.

PubMed

Herson, M R; Hamilton, K; White, J; Alexander, D; Poniatowski, S; O'Connor, A J; Werkmeister, J A

2018-04-25

Current regulatory requirements demand an in-depth understanding and validation of protocols used in tissue banking. The aim of this work was to characterize the quality of split thickness skin allografts cryopreserved or manufactured using highly concentrated solutions of glycerol (50, 85 or 98%), where tissue water activity (a w ), histology and birefringence changes were chosen as parameters. Consistent a w outcomes validated the proposed processing protocols. While no significant changes in tissue quality were observed under bright-field microscopy or in collagen birefringence, in-process findings can be harnessed to fine-tune and optimize manufacturing outcomes in particular when further radiation sterilization is considered. Furthermore, exposing the tissues to 85% glycerol seems to derive the most efficient outcomes as far as a w and control of microbiological growth.

Organizational change tactics: the evidence base in the literature.

PubMed

Packard, Thomas; Shih, Amber

2014-01-01

Planned organizational change processes can be used to address the many challenges facing human service organizations (HSOs) and improve organizational outcomes. There is massive literature on organizational change, ranging from popular management books to academic research on specific aspects of change. Regarding HSOs, there is a growing literature, including increasing attention to implementation science and evidence-based practices. However, research which offers generalizable, evidence-based guidelines for implementing change is not common. The purpose of the authors was to assess the evidence base in this organizational change literature to lay the groundwork for more systematic knowledge development in this important field.

Social Climate Science: A New Vista for Psychological Science.

PubMed

Pearson, Adam R; Schuldt, Jonathon P; Romero-Canyas, Rainer

2016-09-01

The recent Paris Agreement to limit greenhouse gas emissions, adopted by 195 nations at the 2015 United Nations Climate Change Conference, signaled unprecedented commitment by world leaders to address the human social aspects of climate change. Indeed, climate change increasingly is recognized by scientists and policymakers as a social issue requiring social solutions. However, whereas psychological research on intrapersonal and some group-level processes (e.g., political polarization of climate beliefs) has flourished, research into other social processes-such as an understanding of how nonpartisan social identities, cultural ideologies, and group hierarchies shape public engagement on climate change-has received substantially less attention. In this article, we take stock of current psychological approaches to the study of climate change to explore what is "social" about climate change from the perspective of psychology. Drawing from current interdisciplinary perspectives and emerging empirical findings within psychology, we identify four distinct features of climate change and three sets of psychological processes evoked by these features that are fundamentally social and shape both individual and group responses to climate change. Finally, we consider how a more nuanced understanding of the social underpinnings of climate change can stimulate new questions and advance theory within psychology. © The Author(s) 2016.

M-CSF increases proliferation and phagocytosis while modulating receptor and transcription factor expression in adult human microglia

PubMed Central

2013-01-01

Background Microglia are the primary immune cells of the brain whose phenotype largely depends on their surrounding micro-environment. Microglia respond to a multitude of soluble molecules produced by a variety of brain cells. Macrophage colony-stimulating factor (M-CSF) is a cytokine found in the brain whose receptor is expressed by microglia. Previous studies suggest a critical role for M-CSF in brain development and normal functioning as well as in several disease processes involving neuroinflammation. Methods Using biopsy tissue from patients with intractable temporal epilepsy and autopsy tissue, we cultured primary adult human microglia to investigate their response to M-CSF. Mixed glial cultures were treated with 25 ng/ml M-CSF for 96 hours. Proliferation and phagocytosis assays, and high through-put immunocytochemistry, microscopy and image analysis were performed to investigate microglial phenotype and function. Results We found that the phenotype of primary adult human microglia was markedly changed following exposure to M-CSF. A greater number of microglia were present in the M-CSF- treated cultures as the percentage of proliferating (BrdU and Ki67-positive) microglia was greatly increased. A number of changes in protein expression occurred following M-CSF treatment, including increased transcription factors PU.1 and C/EBPβ, increased DAP12 adaptor protein, increased M-CSF receptor (CSF-1R) and IGF-1 receptor, and reduced HLA-DP, DQ, DR antigen presentation protein. Furthermore, a distinct morphological change was observed with elongation of microglial processes. These changes in phenotype were accompanied by a functional increase in phagocytosis of Aβ1-42 peptide. Conclusions We show here that the cytokine M-CSF dramatically influences the phenotype of adult human microglia. These results pave the way for future investigation of M-CSF-related targets for human therapeutic benefit. PMID:23866312

Gravity and neuronal adaptation, in vitro and in vivo-from neuronal cells up to neuromuscular responses: a first model.

PubMed

Kohn, Florian P M; Ritzmann, Ramona

2018-03-01

For decades it has been shown that acute changes in gravity have an effect on neuronal systems of human and animals on different levels, from the molecular level to the whole nervous system. The functional properties and gravity-dependent adaptations of these system levels have been investigated with no or barely any interconnection. This review summarizes the gravity-dependent adaptation processes in human and animal organisms from the in vitro cellular level with its biophysical properties to the in vivo motor responses and underlying sensorimotor functions of human subjects. Subsequently, a first model for short-term adaptation of neuronal transmission is presented and discussed for the first time, which integrates the responses of the different levels of organization to changes in gravity.

Influence of prolonged storage process, pasteurization, and heat treatment on biologically-active human milk proteins.

PubMed

Chang, Jih-Chin; Chen, Chao-Huei; Fang, Li-Jung; Tsai, Chi-Ren; Chang, Yu-Chuan; Wang, Teh-Ming

2013-12-01

The bioactive proteins in human milk may be influenced by prolonged storage process, pasteurization, and heat treatment. This study was conducted to evaluate the effects of these procedures. Three forms of human milk - freshly expressed, frozen at -20°C for a prolonged duration, and pasteurized milk - were collected from 14 healthy lactating mothers and a milk bank. The concentrations of major bioactive proteins (secretory immunoglobulin A, lactoferrin, lysozyme, and leptin) were quantified using enzyme-linked immunosorbent assay kits. Changes in these proteins by heat treatment at 40°C or 60°C for 30 minutes were further evaluated. The mean concentrations of lactoferrin and secretory immunoglobulin A were significantly reduced by 66% and 25.9%, respectively, in pasteurized milk compared with those in freshly-expressed milk. Heat treatment at 40°C or 60°C did not cause significant changes in lactoferrin and secretory immunoglobulin A, but there was an apparent increase in lysozyme (p = 0.016). There were no significant differences in leptin level among these three forms of milk prior to (p = 0.153) or after heat treatment (p = 0.053). Various freezing/heating/pasteurization processes applied to human milk prior to delivery to neonates could affect the concentration of immunomodulatory proteins, especially lactoferrin, secretory immunoglobulin A, and lysozyme. Leptin was unaffected by the various handling processes tested. Fresh milk was found to be the best food for neonates. Further studies are warranted to evaluate the functional activity of these proteins and their effects on infants' immunological status. Copyright © 2013. Published by Elsevier B.V.

Preparation of Artificial Skin that Mimics Human Skin Surface and Mechanical Properties.

PubMed

Shimizu, Rana; Nonomura, Yoshimune

2018-01-01

We have developed an artificial skin that mimics the morphological and mechanical properties of human skin. The artificial skin comprises a polyurethane block possessing a microscopically rough surface. We evaluated the tactile sensations when skin-care cream was applied to the artificial skin. Many subjects perceived smooth, moist, and soft feels during the application process. Cluster analysis showed that these characteristic tactile feels are similar to those when skin-care cream is applied to real human skin. Contact angle analysis showed that an oil droplet spread smoothly on the artificial skin surface, which occurred because there were many grooves several hundred micrometers in width on the skin surface. In addition, when the skin-care cream was applied, the change in frictional force during the dynamic friction process increased. These wetting and frictional properties are important factors controlling the similarity of artificial skin to real human skin.

Proposal of Self-Learning and Recognition System of Facial Expression

NASA Astrophysics Data System (ADS)

Ogawa, Yukihiro; Kato, Kunihito; Yamamoto, Kazuhiko

We describe realization of more complicated function by using the information acquired from some equipped unripe functions. The self-learning and recognition system of the human facial expression, which achieved under the natural relation between human and robot, are proposed. The robot with this system can understand human facial expressions and behave according to their facial expressions after the completion of learning process. The system modelled after the process that a baby learns his/her parents’ facial expressions. Equipping the robot with a camera the system can get face images and equipping the CdS sensors on the robot’s head the robot can get the information of human action. Using the information of these sensors, the robot can get feature of each facial expression. After self-learning is completed, when a person changed his facial expression in front of the robot, the robot operates actions under the relevant facial expression.

On the trails of markers and proxies: the socio-cognitive technologies of human movement, knowledge assemblage, and their relevance to the etiology of nasopharyngeal carcinoma

PubMed Central

Turnbull, David

2011-01-01

Bacteria, pigs, rats, pots, plants, words, bones, stones, earrings, diseases, and genetic indicators of all varieties are markers and proxies for the complexity of interweaving trails and stories integral to understanding human movement and knowledge assemblage in Southeast Asia and around the world. Understanding human movement and knowledge assemblage is central to comprehending the genetic basis of disease, especially of a cancer like nasopharyngeal carcinoma. The problem is that the markers and trails, taken in isolation, do not all tell the same story. Human movement and knowledge assemblage are in constant interaction in an adaptive process of co-production with genes, terrain, climate, sea level changes, kinship relations, diet, materials, food and transport technologies, social and cognitive technologies, and knowledge strategies and transmission. Nasopharyngeal carcinoma is the outcome of an adaptive process involving physical, social, and genetic components. PMID:21272440

Quantifying the magnitude of the impact of climate change and human activity on runoff decline in Mian River Basin, China.

PubMed

Fan, Jing; Tian, Fei; Yang, Yonghui; Han, Shumin; Qiu, Guoyu

2010-01-01

Runoff in North China has been dramatically declining in recent decades. Although climate change and human activity have been recognized as the primary driving factors, the magnitude of impact of each of the above factors on runoff decline is still not entirely clear. In this study, Mian River Basin (a watershed that is heavily influenced by human activity) was used as a proxy to quantify the contributions of human and climate to runoff decline in North China. SWAT (Soil and Water Assessment Tool) model was used to isolate the possible impacts of man and climate. SWAT simulations suggest that while climate change accounts for only 23.89% of total decline in mean annual runoff, human activity accounts for the larger 76.11% in the basin. The gap between the simulated and measured runoff has been widening since 1978, which can only be explained in terms of increasing human activity in the region. Furthermore, comparisons of similar annual precipitation in 3 dry-years and 3 wet-years representing hydrological processes in the 1970s, 1980s, and 1990s were used to isolate the magnitude of runoff decline under similar annual precipitations. The results clearly show that human activity, rather than climate, is the main driving factor of runoff decline in the basin.

Area and percent of forest affected by abiotic agents beyond reference conditions

Treesearch

2012-01-01

Criterion 3, Indicator 16, of the Montréal Process Criteria and Indicators for the Conservation and Sustainable Management of Temperate and Boreal Forests was designed to assess the impact of abiotic agents upon forests (Montréal Process Working Group 2007). Various abiotic agents, both natural and human-induced, can change forest structure and species composition....

Explanation of climate and human impacts on sediment discharge change in Darwinian hydrology: Derivation of a differential equation

NASA Astrophysics Data System (ADS)

Zhang, Jianjun; Gao, Guangyao; Fu, Bojie; Zhang, Lu

2018-04-01

The assessment for impacts of climate variability and human activities on suspended sediment yield (SSY) change has long been a question of great interest. However, the sediment generation processes are sophisticated with high nonlinearity and great uncertainty, which give rise to extreme complexity for SSY change assessment in Newtonian approach. Consequently, few approaches can be simply but widely applied to decompose impacts of climatic variability and human activities on SSY change. Thus, it is an urgent need to develop advanced methods that are simple and robust. Since that the Newtonian approach is hardly achievable due to limitation of either observations or knowledge of mechanisms, there have been repeated calls to capture the hydrologic system in Darwinian approach for hydrological change prediction or explanation. As streamflow is the carrier of suspended sediment, SSY change are thus documented in changes of sediment concentrated flow and suspended sediment concentration - water discharge (C-Q) relationships. By deduced corollaries, a differential equation of sediment discharge change was derived to explicitly decompose impacts of climate variability and human activities in Darwinian hydrology. Besides, a new form of sediment rating curves was proposed and curved as C-Q relationships and probability distribution of sediment concentrated flow. River sediment flux can be revealed by this representation, which simply elucidates mechanism of SSY generation covering a range of time scales from finer than rainfall-event to long term. By the new sediment rating curves, the differential equation was partly solved using a segmentation algorithm proposed and validated in this paper, and then was submitted to water balance framework expressed by Budyko-type equation. Thus, for catchment management, hydrologists can obtain explicit explanation of how climate variation and human activities propagate through landscape and result in sediment discharge change. The differential equation is simple and robust for widely application in sediment discharge change assessment, as only discrete data of precipitation, potential evaporation and C-Q observed at gauging stations are required.

A Fuzzy Cognitive Model of aeolian instability across the South Texas Sandsheet

NASA Astrophysics Data System (ADS)

Houser, C.; Bishop, M. P.; Barrineau, C. P.

2014-12-01

Characterization of aeolian systems is complicated by rapidly changing surface-process regimes, spatio-temporal scale dependencies, and subjective interpretation of imagery and spatial data. This paper describes the development and application of analytical reasoning to quantify instability of an aeolian environment using scale-dependent information coupled with conceptual knowledge of process and feedback mechanisms. Specifically, a simple Fuzzy Cognitive Model (FCM) for aeolian landscape instability was developed that represents conceptual knowledge of key biophysical processes and feedbacks. Model inputs include satellite-derived surface biophysical and geomorphometric parameters. FCMs are a knowledge-based Artificial Intelligence (AI) technique that merges fuzzy logic and neural computing in which knowledge or concepts are structured as a web of relationships that is similar to both human reasoning and the human decision-making process. Given simple process-form relationships, the analytical reasoning model is able to map the influence of land management practices and the geomorphology of the inherited surface on aeolian instability within the South Texas Sandsheet. Results suggest that FCMs can be used to formalize process-form relationships and information integration analogous to human cognition with future iterations accounting for the spatial interactions and temporal lags across the sand sheets.

Historical change and evolutionary theory.

PubMed

Masters, Roger D

2007-09-01

Despite advances in fields like genetics, evolutionary psychology, and human behavior and evolution--which generally focus on individual or small group behavior from a biological perspective--evolutionary biology has made little impact on studies of political change and social history. Theories of natural selection often seem inapplicable to human history because our social behavior is embedded in language (which makes possible the concepts of time and social identity on which what we call "history" depends). Peter Corning's Holistic Darwinism reconceptualizes evolutionary biology, making it possible to go beyond the barriers separating the social and natural sciences. Corning focuses on two primary processes: "synergy" (complex multivariate interactions at multiple levels between a species and its environment) and "cybernetics" (the information systems permitting communication between individuals and groups over time). Combining this frame of reference with inclusive fitness theory, it is possible to answer the most important (and puzzling) question in human history: How did a species that lived for millennia in hunter-gatherer bands form centralized states governing large populations of non-kin (including multi-ethnic empires as well as modern nation-states)? The fragility and contemporary ethnic violence in Kenya and the Congo should suffice as evidence that these issues need to be taken seriously. To explain the rise and fall of states as well as changes in human laws and customs--the core of historical research--it is essential to show how the provision of collective goods can overcome the challenge of self-interest and free-riding in some instances, yet fail to do so in others. To this end, it is now possible to consider how a state providing public goods can--under circumstances that often include effective leadership--contribute to enhanced inclusive fitness of virtually all its members. Because social behavior needs to adapt to ecology, but ecological systems are constantly transformed by human technology and social behavior, multilevel evolutionary processes can explain two central features of human history: the rise, transformations, and ultimate fall of centralized governments (the "stuff" of history); and the biological uniqueness of Homo sapiens as the mammalian species that colonized--and became top carnivore--in virtually every habitable environment on the earth's surface. Once scholars admit the necessity of linking processes of natural selection with human transformations of the natural world, it will seem anomalous that it has taken so long to integrate Darwinian biology and the social sciences.

Change-point detection of induced and natural seismicity

NASA Astrophysics Data System (ADS)

Fiedler, B.; Holschneider, M.; Zoeller, G.; Hainzl, S.

2016-12-01

Earthquake rates are influenced by tectonic stress buildup, earthquake-induced stress changes, and transient aseismic sources. While the first two sources can be well modeled due to the fact that the source is known, transient aseismic processes are more difficult to detect. However, the detection of the associated changes of the earthquake activity is of great interest, because it might help to identify natural aseismic deformation patterns (such as slow slip events) and the occurrence of induced seismicity related to human activities. We develop a Bayesian approach to detect change-points in seismicity data which are modeled by Poisson processes. By means of a Likelihood-Ratio-Test, we proof the significance of the change of the intensity. The model is also extended to spatiotemporal data to detect the area of the transient changes. The method is firstly tested for synthetic data and then applied to observational data from central US and the Bardarbunga volcano in Iceland.

Developmental trajectories during adolescence in males and females: a cross-species understanding of underlying brain changes

PubMed Central

Brenhouse, Heather C.; Andersen, Susan L.

2011-01-01

Adolescence is a transitional period between childhood and adulthood that encompasses vast changes within brain systems that parallel some, but not all, behavioral changes. Elevations in emotional reactivity and reward processing follow an inverted U shape in terms of onset and remission, with the peak occurring during adolescence. However, cognitive processing follows a more linear course of development. This review will focus on changes within key structures and will highlight the relationships between brain changes and behavior, with evidence spanning from functional magnetic resonance imaging (fMRI) in humans to molecular studies of receptor and signaling factors in animals. Adolescent changes in neuronal substrates will be used to understand how typical and atypical behaviors arise during adolescence. We draw upon clinical and preclinical studies to provide a neural framework for defining adolescence and its role in the transition to adulthood. PMID:21600919

Individual human cell responses to low doses of chemicals studied by synchrotron infrared spectromicroscopy

NASA Astrophysics Data System (ADS)

Holman, Hoi-Ying N.; Goth-Goldstein, Regine; Blakely, Elanor A.; Bjornstad, Kathy; Martin, Michael C.; McKinney, Wayne R.

2000-05-01

Vibrational spectroscopy, when combined with synchrotron radiation-based (SR) microscopy, is a powerful new analytical tool with high spatial resolution for detecting biochemical changes in the individual living cells. In contrast to other microscopy methods that require fixing, drying, staining or labeling, SR-FTIR microscopy probes intact living cells providing a composite view of all of the molecular response and the ability to monitor the response over time in the same cell. Observed spectral changes include all types of lesions induced in that cell as well as cellular responses to external and internal stresses. These spectral changes combined with other analytical tools may provide a fundamental understanding of the key molecular mechanisms induced in response to stresses created by low- doses of chemicals. In this study we used the high spatial - resolution SR-FTIR vibrational spectromicroscopy as a sensitive analytical tool to detect chemical- and radiation- induced changes in individual human cells. Our preliminary spectral measurements indicate that this technique is sensitive enough to detect changes in nucleic acids and proteins of cells treated with environmentally relevant concentrations of dioxin. This technique has the potential to distinguish changes from exogenous or endogenous oxidative processes. Future development of this technique will allow rapid monitoring of cellular processes such as drug metabolism, early detection of disease, bio- compatibility of implant materials, cellular repair mechanisms, self assembly of cellular apparatus, cell differentiation and fetal development.

Sacred Values, Strategic Communication, and Military Operations in Afghanistan

DTIC Science & Technology

2010-02-17

remembrance afterward is nothing less than a people‟s mass. War is the liturgy of identity.” Michael Vlahos 20 Combatant commanders (COCOMs) require...development. Identify Formation: Michael Vlahos ―…maintains that the process of globalization ushered into human consciousness a crisis of human change...provide contexts for the clash of political will. Conflict provides stories, symbols, and rituals that create narratives and form identity. Vlahos

Using Empowering Processes to Create Empowered Outcomes through the Family Development Credential Program: An Empirical Study of Change in Human Service Workers

ERIC Educational Resources Information Center

Hewitt, Nicole M.

2010-01-01

This study employed a quasi-experimental non-equivalent control group design with pretest and posttest. Two waves of data were collected from a non-random sample of 180 human service professionals in Western and Central Pennsylvania using two research instruments: the Social Work Empowerment Scale and the Conditions of Work Effectiveness-II Scale.…

Human-provided waters for desert wildlife: What is the problem?

USGS Publications Warehouse

Mattson, D.J.; Chambers, N.

2009-01-01

Conflict persists in southwestern deserts of the United States over management of human-constructed devices to provide wildlife with water. We appraised decision processes in this case relative to the goal of human dignity and by the standards of civility and common interest outcomes. Our analysis suggested that conflict was scientized, rooted in worldviews, and aggravated by use of inflammatory symbols such as "wilderness" and "bighorn sheep." Contested problem definitions, framed as matters of science, advanced factional interests largely by allocating the burden of proof and failing to disclose private concerns about well-being, affection, respect, skill and power. Decision processes were shaped by precepts of scientific management, and thus largely failed to foster civility, common ground, and a focus on common interests, and instead tended to exacerbate deprivations of dignity and respect. If the status quo continues, we foresee further erosion of human dignity because there are likely to be increases in system stressors, such as climate change and human population growth. The prognosis would be more hopeful if alternatives were adopted that entailed authoritative, equitable, and collaborative public decision-making processes that took into consideration national-level common interests such as the U.S. Endangered Species Act. ?? Springer Science+Business Media, LLC. 2008.

Temperature resolution enhancing of commercially available IR camera using computer processing

NASA Astrophysics Data System (ADS)

Trofimov, Vyacheslav A.; Trofimov, Vladislav V.

2015-09-01

As it is well-known, application of the passive THz camera for the security problems is very promising way. It allows seeing concealed object without contact with a person and this camera is non-dangerous for a person. Using such THz camera, one can see a temperature difference on the human skin if this difference is caused by different temperatures inside the body. Because the passive THz camera is very expensive, we try to use the IR camera for observing of such phenomenon. We use a computer code that is available for treatment of the images captured by commercially available IR camera, manufactured by Flir Corp. Using this code we demonstrate clearly changing of human body skin temperature induced by water drinking. Nevertheless, in some cases it is necessary to use additional computer processing to show clearly changing of human body temperature. One of these approaches is developed by us. We believe that we increase ten times (or more) the temperature resolution of such camera. Carried out experiments can be used for solving the counter-terrorism problem and for medicine problems solving. Shown phenomenon is very important for the detection of forbidden objects and substances concealed inside the human body using non-destructive control without X-ray application. Early we have demonstrated such possibility using THz radiation.

Adaptive Parameter Estimation of Person Recognition Model in a Stochastic Human Tracking Process

NASA Astrophysics Data System (ADS)

Nakanishi, W.; Fuse, T.; Ishikawa, T.

2015-05-01

This paper aims at an estimation of parameters of person recognition models using a sequential Bayesian filtering method. In many human tracking method, any parameters of models used for recognize the same person in successive frames are usually set in advance of human tracking process. In real situation these parameters may change according to situation of observation and difficulty level of human position prediction. Thus in this paper we formulate an adaptive parameter estimation using general state space model. Firstly we explain the way to formulate human tracking in general state space model with their components. Then referring to previous researches, we use Bhattacharyya coefficient to formulate observation model of general state space model, which is corresponding to person recognition model. The observation model in this paper is a function of Bhattacharyya coefficient with one unknown parameter. At last we sequentially estimate this parameter in real dataset with some settings. Results showed that sequential parameter estimation was succeeded and were consistent with observation situations such as occlusions.

A study of adsorption behavior of human serum albumin and ovalbumin on hydroxyapatite/chitosan composite.

PubMed

Xu, Chao; He, Deliang; Zeng, Liping; Luo, Shenglian

2009-10-15

In situ adsorption of human serum albumin (HSA) and ovalbumin (OVA) was real-time monitored by piezoelectric quartz crystal impedance (PQCI) technique to fully understand the initial cellular response on hydroxyapatite/chitosan (HAP/CS) composite. The PQCI parameters, such as resonant frequency (f), static capacitance (C(s)), and motional resistance (R(m)) were measured for investigating the kinetic adsorption behaviors of both proteins. The change in frequency shifts (Deltaf) depends on the amount of the adsorbed protein, and the change in motional resistance (DeltaR(m)) results from the microporosity variation of HAP/CS coating. The results show that the amount of the absorbed HSA is much greater than that of OVA on HAP/CS coating because of the unique construction of HSA as well as a flexible protein. Furthermore, Deltaf and DeltaR(m) data were fitted according to the kinetic exponential decay equations. It can be seen that there is only one adsorption process for OVA, but the absorption process for HSA is followed by a rearrangement process, and the former process is faster than the rearrangement process. Subsequently, the composite binding with proteins were demonstrated by the Fourier transform infrared (FTIR), cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS).

Pattern and process of biotic homogenization in the New Pangaea

PubMed Central

Baiser, Benjamin; Olden, Julian D.; Record, Sydne; Lockwood, Julie L.; McKinney, Michael L.

2012-01-01

Human activities have reorganized the earth's biota resulting in spatially disparate locales becoming more or less similar in species composition over time through the processes of biotic homogenization and biotic differentiation, respectively. Despite mounting evidence suggesting that this process may be widespread in both aquatic and terrestrial systems, past studies have predominantly focused on single taxonomic groups at a single spatial scale. Furthermore, change in pairwise similarity is itself dependent on two distinct processes, spatial turnover in species composition and changes in gradients of species richness. Most past research has failed to disentangle the effect of these two mechanisms on homogenization patterns. Here, we use recent statistical advances and collate a global database of homogenization studies (20 studies, 50 datasets) to provide the first global investigation of the homogenization process across major faunal and floral groups and elucidate the relative role of changes in species richness and turnover. We found evidence of homogenization (change in similarity ranging from −0.02 to 0.09) across nearly all taxonomic groups, spatial extent and grain sizes. Partitioning of change in pairwise similarity shows that overall change in community similarity is driven by changes in species richness. Our results show that biotic homogenization is truly a global phenomenon and put into question many of the ecological mechanisms invoked in previous studies to explain patterns of homogenization. PMID:23055062

Pattern and process of biotic homogenization in the New Pangaea.

PubMed

Baiser, Benjamin; Olden, Julian D; Record, Sydne; Lockwood, Julie L; McKinney, Michael L

2012-12-07

Human activities have reorganized the earth's biota resulting in spatially disparate locales becoming more or less similar in species composition over time through the processes of biotic homogenization and biotic differentiation, respectively. Despite mounting evidence suggesting that this process may be widespread in both aquatic and terrestrial systems, past studies have predominantly focused on single taxonomic groups at a single spatial scale. Furthermore, change in pairwise similarity is itself dependent on two distinct processes, spatial turnover in species composition and changes in gradients of species richness. Most past research has failed to disentangle the effect of these two mechanisms on homogenization patterns. Here, we use recent statistical advances and collate a global database of homogenization studies (20 studies, 50 datasets) to provide the first global investigation of the homogenization process across major faunal and floral groups and elucidate the relative role of changes in species richness and turnover. We found evidence of homogenization (change in similarity ranging from -0.02 to 0.09) across nearly all taxonomic groups, spatial extent and grain sizes. Partitioning of change in pairwise similarity shows that overall change in community similarity is driven by changes in species richness. Our results show that biotic homogenization is truly a global phenomenon and put into question many of the ecological mechanisms invoked in previous studies to explain patterns of homogenization.

Community assembly processes underlying phytoplankton and bacterioplankton across a hydrologic change in a human-impacted river.

PubMed

Isabwe, Alain; Yang, Jun R; Wang, Yongming; Liu, Lemian; Chen, Huihuang; Yang, Jun

2018-07-15

Although the influence of microbial community assembly processes on aquatic ecosystem function and biodiversity is well known, the processes that govern planktonic communities in human-impacted rivers remain largely unstudied. Here, we used multivariate statistics and a null model approach to test the hypothesis that environmental conditions and obstructed dispersal opportunities, dictate a deterministic community assembly for phytoplankton and bacterioplankton across contrasting hydrographic conditions in a subtropical mid-sized river (Jiulong River, southeast China). Variation partitioning analysis showed that the explanatory power of local environmental variables was larger than that of the spatial variables for both plankton communities during the dry season. During the wet season, phytoplankton community variation was mainly explained by local environmental variables, whereas the variance in bacterioplankton was explained by both environmental and spatial predictors. The null model based on Raup-Crick coefficients for both planktonic groups suggested little evidences of the stochastic processes involving dispersal and random distribution. Our results showed that hydrological change and landscape structure act together to cause divergence in communities along the river channel, thereby dictating a deterministic assembly and that selection exceeds dispersal limitation during the dry season. Therefore, to protect the ecological integrity of human-impacted rivers, watershed managers should not only consider local environmental conditions but also dispersal routes to account for the effect of regional species pool on local communities. Copyright © 2018 Elsevier B.V. All rights reserved.

Adsorption of human tear lipocalin to human meibomian lipid films.

PubMed

Millar, Thomas J; Mudgil, Poonam; Butovich, Igor A; Palaniappan, Chendur K

2009-01-01

Tear lipocalin (Tlc) is a major lipid binding protein in tears and is thought to have an important role in stabilizing the Meibomian lipid layer by transferring lipids to it from the aqueous layer or ocular surface, or by adsorbing to it directly. These possible roles have been investigated in vitro using human Tlc. Tlc was purified from human tears by size exclusion chromatography followed by ion exchange chromatography. Three additional samples of the Tlc were prepared by lipidation, delipidation, and relipidation. The lipids extracted from the purified Tlc were analyzed by HPLC-MS followed by fragmentation. Adsorption of these different forms of Tlc to a human Meibomian lipid film spread on the surface of an artificial tear buffer in a Langmuir trough were observed by recording changes in the pressure with time (Pi-T profile) and monitoring the appearance of the film microscopically. These results were compared with similar experiments using a bovine Meibomian lipid film. The results indicated that Tlc binds slowly to a human Meibomian lipid film compared with lysozyme or lactoferrin, even at 37 degrees C. The adsorption of Tlc to a human Meibomian lipid film was very different from its adsorption to a bovine Meibomian lipid film, indicating the nature of the lipids in the film is critical to the adsorption process. Similarly, the different forms of Tlc had quite distinct adsorption patterns, as indicated both by changes in Pi-T profiles and the microscopic appearance of the films. It was concluded that human Tlc was capable of adsorbing to and penetrating into a Meibomian lipid layer, but this process is very complex and depends on both the types of lipids bound to Tlc and the lipid complement comprising the Meibomian lipid film.

Adsorption of Human Tear Lipocalin to Human Meibomian Lipid Films

PubMed Central

Millar, Thomas J.; Mudgil, Poonam; Butovich, Igor A.; Palaniappan, Chendur K.

2009-01-01

Purpose Tear lipocalin (Tlc) is a major lipid binding protein in tears and is thought to have an important role in stabilizing the Meibomian lipid layer by transferring lipids to it from the aqueous layer or ocular surface, or by adsorbing to it directly. These possible roles have been investigated in vitro using human Tlc. Methods Tlc was purified from human tears by size exclusion chromatography followed by ion exchange chromatography. Three additional samples of the Tlc were prepared by lipidation, delipidation, and relipidation. The lipids extracted from the purified Tlc were analyzed by HPLC-MS followed by fragmentation. Adsorption of these different forms of Tlc to a human Meibomian lipid film spread on the surface of an artificial tear buffer in a Langmuir trough were observed by recording changes in the pressure with time (∏-T profile) and monitoring the appearance of the film microscopically. These results were compared with similar experiments using a bovine Meibomian lipid film. Results The results indicated that Tlc binds slowly to a human Meibomian lipid film compared with lysozyme or lactoferrin, even at 37°C. The adsorption of Tlc to a human Meibomian lipid film was very different from its adsorption to a bovine Meibomian lipid film, indicating the nature of the lipids in the film is critical to the adsorption process. Similarly, the different forms of Tlc had quite distinct adsorption patterns, as indicated both by changes in ∏-T profiles and the microscopic appearance of the films. Conclusions It was concluded that human Tlc was capable of adsorbing to and penetrating into a Meibomian lipid layer, but this process is very complex and depends on both the types of lipids bound to Tlc and the lipid complement comprising the Meibomian lipid film. PMID:18757516

Cryptic genetic variation: evolution's hidden substrate.

PubMed

Paaby, Annalise B; Rockman, Matthew V

2014-04-01

Cryptic genetic variation (CGV) is invisible under normal conditions, but it can fuel evolution when circumstances change. In theory, CGV can represent a massive cache of adaptive potential or a pool of deleterious alleles that are in need of constant suppression. CGV emerges from both neutral and selective processes, and it may inform about how human populations respond to change. CGV facilitates adaptation in experimental settings, but does it have an important role in the real world? Here, we review the empirical support for widespread CGV in natural populations, including its potential role in emerging human diseases and the growing evidence of its contribution to evolution.

Human Aging: Usual and Successful.

ERIC Educational Resources Information Center

Rowe, John W.; Kahn, Robert L.

1987-01-01

Offers perspectives on the role of extrinsic factors in the aging process, the long-term consequences of extrinsically initiated changes, and implications for gerontological research. Explains the distinction between usual and successful aging in light of physiologic and psychosocial characteristics. (ML)

Aging and immunosenescence in invertebrates

USDA-ARS?s Scientific Manuscript database

Most contemporary research into aging is driven by interest in the human aging process and in interventions that attenuate the normal and pathophysiological effects of aging, or senescence. Operationally, senescence is the progressive, inevitable breakdown of the organism. Among the changes associat...

Runoff response to climate change and human activities in a typical karst watershed, SW China.

PubMed

Xu, Yan; Wang, Shijie; Bai, Xiaoyong; Shu, Dongcai; Tian, Yichao

2018-01-01

This study aims to reveal the runoff variation characteristics of long time series in a karst region, analyse comprehensively its different driving factors, and estimate quantitatively the contribution rates of climate change and human activities to net runoff variation. Liudong river basin, a typical karst watershed in southwest China, is the study site. Statistical methods, such as linear fitting, the Morlet wavelet analysis, normalized curve and double mass curve, are applied to analyse the runoff of the watershed. Results show that the runoff in the karst watershed during the research period exhibits a three-stage change and the abrupt change points are the years 1981 and 2007: (1) 1968-1980, the runoff initially exhibited a trend of sustained decreasing and then an abrupt fluctuation. The runoff was obviously destroyed through precipitation-producing processes. Improper land utilisation and serious forest and grass destruction intensified the fluctuation variation amplitude of the runoff. (2) 1981-2006, the changing processes of runoff and precipitation exhibited good synchronism. Precipitation significantly affected runoff variation and human activities had a slight interference degree. (3) 2007-2013, the fluctuation range of runoff was considerably smaller than that of precipitation. The significant growth of forest and grassland areas and the increase in water consumption mitigated runoff fluctuation and greatly diminished runoff variation amplitude. According to calculation, the relative contribution rates of precipitation and human activities to net runoff variation with 1981-2007 as the reference period were -81% and 181% in average, respectively, during 1968-1980, and -117% and 217% in average, respectively, during 2007-2013. In general, the analysis of runoff variation trend and of the contribution rate of its main influencing factors in the typical karst watershed for nearly half a century may be significant to solve the drought problem in the karst region and for the sustainable development of the drainage basin.

Runoff response to climate change and human activities in a typical karst watershed, SW China

PubMed Central

Xu, Yan; Wang, Shijie; Shu, Dongcai; Tian, Yichao

2018-01-01

This study aims to reveal the runoff variation characteristics of long time series in a karst region, analyse comprehensively its different driving factors, and estimate quantitatively the contribution rates of climate change and human activities to net runoff variation. Liudong river basin, a typical karst watershed in southwest China, is the study site. Statistical methods, such as linear fitting, the Morlet wavelet analysis, normalized curve and double mass curve, are applied to analyse the runoff of the watershed. Results show that the runoff in the karst watershed during the research period exhibits a three-stage change and the abrupt change points are the years 1981 and 2007: (1) 1968–1980, the runoff initially exhibited a trend of sustained decreasing and then an abrupt fluctuation. The runoff was obviously destroyed through precipitation-producing processes. Improper land utilisation and serious forest and grass destruction intensified the fluctuation variation amplitude of the runoff. (2) 1981–2006, the changing processes of runoff and precipitation exhibited good synchronism. Precipitation significantly affected runoff variation and human activities had a slight interference degree. (3) 2007–2013, the fluctuation range of runoff was considerably smaller than that of precipitation. The significant growth of forest and grassland areas and the increase in water consumption mitigated runoff fluctuation and greatly diminished runoff variation amplitude. According to calculation, the relative contribution rates of precipitation and human activities to net runoff variation with 1981–2007 as the reference period were −81% and 181% in average, respectively, during 1968–1980, and −117% and 217% in average, respectively, during 2007–2013. In general, the analysis of runoff variation trend and of the contribution rate of its main influencing factors in the typical karst watershed for nearly half a century may be significant to solve the drought problem in the karst region and for the sustainable development of the drainage basin. PMID:29494602

A stretchable strain sensor based on a metal nanoparticle thin film for human motion detection

NASA Astrophysics Data System (ADS)

Lee, Jaehwan; Kim, Sanghyeok; Lee, Jinjae; Yang, Daejong; Park, Byong Chon; Ryu, Seunghwa; Park, Inkyu

2014-09-01

Wearable strain sensors for human motion detection are being highlighted in various fields such as medical, entertainment and sports industry. In this paper, we propose a new type of stretchable strain sensor that can detect both tensile and compressive strains and can be fabricated by a very simple process. A silver nanoparticle (Ag NP) thin film patterned on the polydimethylsiloxane (PDMS) stamp by a single-step direct transfer process is used as the strain sensing material. The working principle is the change in the electrical resistance caused by the opening/closure of micro-cracks under mechanical deformation. The fabricated stretchable strain sensor shows highly sensitive and durable sensing performances in various tensile/compressive strains, long-term cyclic loading and relaxation tests. We demonstrate the applications of our stretchable strain sensors such as flexible pressure sensors and wearable human motion detection devices with high sensitivity, response speed and mechanical robustness.Wearable strain sensors for human motion detection are being highlighted in various fields such as medical, entertainment and sports industry. In this paper, we propose a new type of stretchable strain sensor that can detect both tensile and compressive strains and can be fabricated by a very simple process. A silver nanoparticle (Ag NP) thin film patterned on the polydimethylsiloxane (PDMS) stamp by a single-step direct transfer process is used as the strain sensing material. The working principle is the change in the electrical resistance caused by the opening/closure of micro-cracks under mechanical deformation. The fabricated stretchable strain sensor shows highly sensitive and durable sensing performances in various tensile/compressive strains, long-term cyclic loading and relaxation tests. We demonstrate the applications of our stretchable strain sensors such as flexible pressure sensors and wearable human motion detection devices with high sensitivity, response speed and mechanical robustness. Electronic supplementary information (ESI) available. See DOI: 10.1039/c4nr03295k

Intra-individual metameric variation expressed at the enamel-dentine junction of lower post-canine dentition of South African fossil hominins and modern humans.

PubMed

Pan, Lei; Thackeray, John Francis; Dumoncel, Jean; Zanolli, Clément; Oettlé, Anna; de Beer, Frikkie; Hoffman, Jakobus; Duployer, Benjamin; Tenailleau, Christophe; Braga, José

2017-08-01

The aim of this study is to compare the degree and patterning of inter- and intra-individual metameric variation in South African australopiths, early Homo and modern humans. Metameric variation likely reflects developmental and taxonomical issues, and could also be used to infer ecological and functional adaptations. However, its patterning along the early hominin postcanine dentition, particularly among South African fossil hominins, remains unexplored. Using microfocus X-ray computed tomography (µXCT) and geometric morphometric tools, we studied the enamel-dentine junction (EDJ) morphology and we investigated the intra- and inter-individual EDJ metameric variation among eight australopiths and two early Homo specimens from South Africa, as well as 32 modern humans. Along post-canine dentition, shape changes between metameres represented by relative positions and height of dentine horns, outlines of the EDJ occlusal table are reported in modern and fossil taxa. Comparisons of EDJ mean shapes and multivariate analyses reveal substantial variation in the direction and magnitude of metameric shape changes among taxa, but some common trends can be found. In modern humans, both the direction and magnitude of metameric shape change show increased variability in M 2 -M 3 compared to M 1 -M 2 . Fossil specimens are clustered together showing similar magnitudes of shape change. Along M 2 -M 3 , the lengths of their metameric vectors are not as variable as those of modern humans, but they display considerable variability in the direction of shape change. The distalward increase of metameric variation along the modern human molar row is consistent with the odontogenetic models of molar row structure (inhibitory cascade model). Though much remains to be tested, the variable trends and magnitudes in metamerism in fossil hominins reported here, together with differences in the scale of shape change between modern humans and fossil hominins may provide valuable information regarding functional morphology and developmental processes in fossil species. © 2017 Wiley Periodicals, Inc.

The Role of Time-Scales in Socio-hydrology

NASA Astrophysics Data System (ADS)

Blöschl, Günter; Sivapalan, Murugesu

2016-04-01

Much of the interest in hydrological modeling in the past decades revolved around resolving spatial variability. With the rapid changes brought about by human impacts on the hydrologic cycle, there is now an increasing need to refocus on time dependency. We present a co-evolutionary view of hydrologic systems, in which every part of the system including human systems, co-evolve, albeit at different rates. The resulting coupled human-nature system is framed as a dynamical system, characterized by interactions of fast and slow time scales and feedbacks between environmental and social processes. This gives rise to emergent phenomena such as the levee effect, adaptation to change and system collapse due to resource depletion. Changing human values play a key role in the emergence of these phenomena and should therefore be considered as internal to the system in a dynamic way. The co-evolutionary approach differs from the traditional view of water resource systems analysis as it allows for path dependence, multiple equilibria, lock-in situations and emergent phenomena. The approach may assist strategic water management for long time scales through facilitating stakeholder participation, exploring the possibility space of alternative futures, and helping to synthesise the observed dynamics of different case studies. Future research opportunities include the study of how changes in human values are connected to human-water interactions, historical analyses of trajectories of system co-evolution in individual places and comparative analyses of contrasting human-water systems in different climate and socio-economic settings. Reference Sivapalan, M. and G. Blöschl (2015) Time scale interactions and the coevolution of humans and water. Water Resour. Res., 51, 6988-7022, doi:10.1002/2015WR017896.

Assessing corporate project impacts in changeable contexts: A human rights perspective

DOE Office of Scientific and Technical Information (OSTI.GOV)

Salcito, Kendyl, E-mail: kendyl.salcito@unibas.ch; University of Basel, P.O. Box, CH-4003 Basel; NomoGaia, 1900 Wazee Street, Suite 303, Denver, CO 80202

Project-level impact assessment was originally conceived as a snapshot taken in advance of project implementation, contrasting current conditions with a likely future scenario involving a variety of predicted impacts. Current best practice guidance has encouraged a shift towards longitudinal assessments from the pre-project stage through the implementation and operating phases. Experience and study show, however, that assessment of infrastructure-intensive projects rarely endures past the project's construction phase. Negative consequences for environmental, social and health outcomes have been documented. Such consequences clarify the pressing need for longitudinal assessment in each of these domains, with human rights impact assessment (HRIA) as anmore » umbrella over, and critical augmentation of, environmental, social and health assessments. Project impacts on human rights are more closely linked to political, economic and other factors beyond immediate effects of a company's policy and action throughout the project lifecycle. Delineating these processes requires an adequate framework, with strategies for collecting longitudinal data, protocols that provide core information for impact assessment and guidance for adaptive mitigation strategies as project-related effects change over time. This article presents general principles for the design and implementation of sustained, longitudinal HRIA, based on experience assessing and responding to human rights impact in a uranium mining project in Malawi. The case study demonstrates the value of longitudinal assessment both for limiting corporate risk and improving human welfare. - Graphical abstract: Assessing changes in human rights condition as affected by both project and context, over time. - Highlights: • Corporate capital projects affect human rights in myriad ways. • Ongoing, longitudinal impact assessment techniques are needed. • We present an approach for conducting longitudinal human rights impact assessment. • Our methodology allows distinguishing corporate impacts from contextual changes. • Promptly observing context changes and impacts enables companies to react nimbly.« less

Quantifying Intrinsic and Extrinsic Contributions to Human Longevity: Application of a Two-Process Vitality Model to the Human Mortality Database.

PubMed

Sharrow, David J; Anderson, James J

2016-12-01

The rise in human life expectancy has involved declines in intrinsic and extrinsic mortality processes associated, respectively, with senescence and environmental challenges. To better understand the factors driving this rise, we apply a two-process vitality model to data from the Human Mortality Database. Model parameters yield intrinsic and extrinsic cumulative survival curves from which we derive intrinsic and extrinsic expected life spans (ELS). Intrinsic ELS, a measure of longevity acted on by intrinsic, physiological factors, changed slowly over two centuries and then entered a second phase of increasing longevity ostensibly brought on by improvements in old-age death reduction technologies and cumulative health behaviors throughout life. The model partitions the majority of the increase in life expectancy before 1950 to increasing extrinsic ELS driven by reductions in environmental, event-based health challenges in both childhood and adulthood. In the post-1950 era, the extrinsic ELS of females appears to be converging to the intrinsic ELS, whereas the extrinsic ELS of males is approximately 20 years lower than the intrinsic ELS.

Quantifying Intrinsic and Extrinsic Contributions to Human Longevity: Application of a Two-Process Vitality Model to the Human Mortality Database

PubMed Central

Anderson, James J.

2016-01-01

The rise in human life expectancy has involved declines in intrinsic and extrinsic mortality processes associated, respectively, with senescence and environmental challenges. To better understand the factors driving this rise, we apply a two-process vitality model to data from the Human Mortality Database. Model parameters yield intrinsic and extrinsic cumulative survival curves from which we derive intrinsic and extrinsic expected life spans (ELS). Intrinsic ELS, a measure of longevity acted on by intrinsic, physiological factors, changed slowly over two centuries and then entered a second phase of increasing longevity ostensibly brought on by improvements in old-age death reduction technologies and cumulative health behaviors throughout life. The model partitions the majority of the increase in life expectancy before 1950 to increasing extrinsic ELS driven by reductions in environmental, event-based health challenges in both childhood and adulthood. In the post-1950 era, the extrinsic ELS of females appears to be converging to the intrinsic ELS, whereas the extrinsic ELS of males is approximately 20 years lower than the intrinsic ELS. PMID:27837429

Pigeons (Columba livia) plan future moves on computerized maze tasks.

PubMed

Miyata, Hiromitsu; Fujita, Kazuo

2008-07-01

Planning, the internal process of formulating an organized method about one's future behavior, should be advantageous for non-human animals as well as for humans. However, little is known about this process in avian species. We examined planning processes in pigeons (Columba livia) using a computerized maze task. In Experiment 1, we found that the pigeons plan their next one step, and in some cases even correctly adjust their actions after change of goal locations, while performing on a plus-shaped maze. We also showed that the pigeons might even plan two steps on familiar, well-practiced mazes. In Experiment 2, we discovered that the subjects plan the direction they would go first before starting to solve a four-arm shuriken (a Japanese traditional throwing knife)-shaped maze. The birds also corrected their previously planned actions after change of goal locations. Our results from these experiments suggest that planning ahead is within the cognitive capacity of a "bird brain", and that it may be more widespread in the animal kingdom than has been presumed.

Evolution of the violin: The law of effect in action.

PubMed

Wasserman, Edward A; Cullen, Patrick

2016-01-01

As is true for most other human inventions, the origin of the violin is unknown. What is known is that this popular and versatile instrument has notably changed over the course of several hundred years. At issue is whether those evolutionary changes in the construction of the violin are the result of premeditated, intelligent design or whether they arose through a trial-and-error process. Recent scientific evidence favors the latter account. Our perspective piece puts these recent empirical findings into a comprehensive selectionist framework. According to this view, the many things we do and make--like violins--arise from a process of variation and selection which accords with the law of effect. Contrary to popular opinion, there is neither mystique nor romance in this process; it is as fundamental and ubiquitous as the law of natural selection. As with the law of natural selection in the evolution of organisms, there is staunch resistance to the role of the law of effect in the evolution of human inventions. We conclude our piece by considering several objections to our perspective. (c) 2016 APA, all rights reserved).