Stress-Neutral Endings in Contemporary British English: An Updated Overview

ERIC Educational Resources Information Center

Trevian, Ives

2007-01-01

The present study is an attempt to account for current changes taking place in the behaviour of what are commonly taken to be stress-neutral endings in contemporary British English. The methodological framework being that of Lionel Guierre, this study aims for comprehensive coverage, via a survey of Guierre's original database (which was initially…

Effects of Neutral Density on Energetic Ions Produced Near High-Current Hollow Cathodes

NASA Technical Reports Server (NTRS)

Kameyama, Ikuya

1997-01-01

Energy distributions of ion current from high-current, xenon hollow cathodes, which are essential information to understand erosion phenomena observed in high-power ion thrusters, were obtained using an electrostatic energy analyzer (ESA). The effects of ambient pressure and external flow rate introduced immediately downstream of hollow cathode on ion currents with energies greater than that associated with the cathode-to-anode potential difference were investigated. The results were analyzed to determine the changes in the magnitudes of ion currents to the ESA at various energies. Either increasing the ambient pressure or adding external flow induces an increase in the distribution of ion currents with moderate energies (epsilon less than 25 to 35 eV) and a decrease in the distribution for high energies (epsilon greater than 25 to 35 eV). The magnitude of the current distribution increase in the moderate energy range is greater for a cathode equipped with a toroidal keeper than for one without a keeper, but the distribution in the high energy range does not seem to be affected by a keeper. An MHD model, which has been proposed to describe energetic-ion production mechanism in hollow cathode at high discharge currents, was developed to describe these effects. The results show, however, that this model involves no mechanism by which a significant increase of ion current could occur at any energy. It was found, on the other hand, that the potential-hill model of energetic ion production, which assumes existence of a local maximum of plasma potential, could explain combined increases in the currents of ions with moderate energies and decreases in high energy ions due to increased neutral atom density using a charge-exchange mechanism. The existing, simplified version of the potential-hill model, however, shows poor quantitative agreement with measured ion-current-energy-distribution changes induced by neutral density changes.

Search for the flavor-changing neutral-current decay t-->Zq in pp collisions at sqrt[s] = 1.96 TeV.

PubMed

Aaltonen, T; Adelman, J; Akimoto, T; Albrow, M G; Alvarez González, B; Amerio, S; Amidei, D; Anastassov, A; Annovi, A; Antos, J; Apollinari, G; Apresyan, A; Arisawa, T; Artikov, A; Ashmanskas, W; Attal, A; Aurisano, A; Azfar, F; Azzurri, P; Badgett, W; Barbaro-Galtieri, A; Barnes, V E; Barnett, B A; Bartsch, V; Bauer, G; Beauchemin, P-H; Bedeschi, F; Bednar, P; Beecher, D; Behari, S; Bellettini, G; Bellinger, J; Benjamin, D; Beretvas, A; Beringer, J; Bhatti, A; Binkley, M; Bisello, D; Bizjak, I; Blair, R E; Blocker, C; Blumenfeld, B; Bocci, A; Bodek, A; Boisvert, V; Bolla, G; Bortoletto, D; Boudreau, J; Boveia, A; Brau, B; Bridgeman, A; Brigliadori, L; Bromberg, C; Brubaker, E; Budagov, J; Budd, H S; Budd, S; Burkett, K; Busetto, G; Bussey, P; Buzatu, A; Byrum, K L; Cabrera, S; Calancha, C; Campanelli, M; Campbell, M; Canelli, F; Canepa, A; Carlsmith, D; Carosi, R; Carrillo, S; Carron, S; Casal, B; Casarsa, M; Castro, A; Catastini, P; Cauz, D; Cavaliere, V; Cavalli-Sforza, M; Cerri, A; Cerrito, L; Chang, S H; Chen, Y C; Chertok, M; Chiarelli, G; Chlachidze, G; Chlebana, F; Cho, K; Chokheli, D; Chou, J P; Choudalakis, G; Chuang, S H; Chung, K; Chung, W H; Chung, Y S; Ciobanu, C I; Ciocci, M A; Clark, A; Clark, D; Compostella, G; Convery, M E; Conway, J; Copic, K; Cordelli, M; Cortiana, G; Cox, D J; Crescioli, F; Cuenca Almenar, C; Cuevas, J; Culbertson, R; Cully, J C; Dagenhart, D; Datta, M; Davies, T; de Barbaro, P; De Cecco, S; Deisher, A; De Lorenzo, G; Dell'Orso, M; Deluca, C; Demortier, L; Deng, J; Deninno, M; Derwent, P F; di Giovanni, G P; Dionisi, C; Di Ruzza, B; Dittmann, J R; D'Onofrio, M; Donati, S; Dong, P; Donini, J; Dorigo, T; Dube, S; Efron, J; Elagin, A; Erbacher, R; Errede, D; Errede, S; Eusebi, R; Fang, H C; Farrington, S; Fedorko, W T; Feild, R G; Feindt, M; Fernandez, J P; Ferrazza, C; Field, R; Flanagan, G; Forrest, R; Franklin, M; Freeman, J C; Furic, I; Gallinaro, M; Galyardt, J; Garberson, F; Garcia, J E; Garfinkel, A F; Genser, K; Gerberich, H; Gerdes, D; Gessler, A; Giagu, S; Giakoumopoulou, V; Giannetti, P; Gibson, K; Gimmell, J L; Ginsburg, C M; Giokaris, N; Giordani, M; Giromini, P; Giunta, M; Giurgiu, G; Glagolev, V; Glenzinski, D; Gold, M; Goldschmidt, N; Golossanov, A; Gomez, G; Gomez-Ceballos, G; Goncharov, M; González, O; Gorelov, I; Goshaw, A T; Goulianos, K; Gresele, A; Grinstein, S; Grosso-Pilcher, C; Grundler, U; Guimaraes da Costa, J; Gunay-Unalan, Z; Haber, C; Hahn, K; Hahn, S R; Halkiadakis, E; Han, B-Y; Han, J Y; Handler, R; Happacher, F; Hara, K; Hare, D; Hare, M; Harper, S; Harr, R F; Harris, R M; Hartz, M; Hatakeyama, K; Hauser, J; Hays, C; Heck, M; Heijboer, A; Heinemann, B; Heinrich, J; Henderson, C; Herndon, M; Heuser, J; Hewamanage, S; Hidas, D; Hill, C S; Hirschbuehl, D; Hocker, A; Hou, S; Houlden, M; Hsu, S-C; Huffman, B T; Hughes, R E; Husemann, U; Huston, J; Incandela, J; Introzzi, G; Iori, M; Ivanov, A; James, E; Jayatilaka, B; Jeon, E J; Jha, M K; Jindariani, S; Johnson, W; Jones, M; Joo, K K; Jun, S Y; Jung, J E; Junk, T R; Kamon, T; Kar, D; Karchin, P E; Kato, Y; Kephart, R; Keung, J; Khotilovich, V; Kilminster, B; Kim, D H; Kim, H S; Kim, J E; Kim, M J; Kim, S B; Kim, S H; Kim, Y K; Kimura, N; Kirsch, L; Klimenko, S; Knuteson, B; Ko, B R; Koay, S A; Kondo, K; Kong, D J; Konigsberg, J; Korytov, A; Kotwal, A V; Kreps, M; Kroll, J; Krop, D; Krumnack, N; Kruse, M; Krutelyov, V; Kubo, T; Kuhr, T; Kulkarni, N P; Kurata, M; Kusakabe, Y; Kwang, S; Laasanen, A T; Lami, S; Lammel, S; Lancaster, M; Lander, R L; Lannon, K; Lath, A; Latino, G; Lazzizzera, I; LeCompte, T; Lee, E; Lee, S W; Leone, S; Lewis, J D; Lin, C S; Linacre, J; Lindgren, M; Lipeles, E; Lister, A; Litvintsev, D O; Liu, C; Liu, T; Lockyer, N S; Loginov, A; Loreti, M; Lovas, L; Lu, R-S; Lucchesi, D; Lueck, J; Luci, C; Lujan, P; Lukens, P; Lungu, G; Lyons, L; Lys, J; Lysak, R; Lytken, E; Mack, P; MacQueen, D; Madrak, R; Maeshima, K; Makhoul, K; Maki, T; Maksimovic, P; Malde, S; Malik, S; Manca, G; Manousakis-Katsikakis, A; Margaroli, F; Marino, C; Marino, C P; Martin, A; Martin, V; Martínez, M; Martínez-Ballarín, R; Maruyama, T; Mastrandrea, P; Masubuchi, T; Mattson, M E; Mazzanti, P; McFarland, K S; McIntyre, P; McNulty, R; Mehta, A; Mehtala, P; Menzione, A; Merkel, P; Mesropian, C; Miao, T; Miladinovic, N; Miller, R; Mills, C; Milnik, M; Mitra, A; Mitselmakher, G; Miyake, H; Moggi, N; Moon, C S; Moore, R; Morello, M J; Morlok, J; Movilla Fernandez, P; Mülmenstädt, J; Mukherjee, A; Muller, Th; Mumford, R; Murat, P; Mussini, M; Nachtman, J; Nagai, Y; Nagano, A; Naganoma, J; Nakamura, K; Nakano, I; Napier, A; Necula, V; Neu, C; Neubauer, M S; Nielsen, J; Nodulman, L; Norman, M; Norniella, O; Nurse, E; Oakes, L; Oh, S H; Oh, Y D; Oksuzian, I; Okusawa, T; Orava, R; Osterberg, K; Griso, S Pagan; Pagliarone, C; Palencia, E; Papadimitriou, V; Papaikonomou, A; Paramonov, A A; Parks, B; Pashapour, S; Patrick, J; Pauletta, G; Paulini, M; Paus, C; Pellett, D E; Penzo, A; Phillips, T J; Piacentino, G; Pianori, E; Pinera, L; Pitts, K; Plager, C; Pondrom, L; Poukhov, O; Pounder, N; Prakoshyn, F; Pronko, A; Proudfoot, J; Ptohos, F; Pueschel, E; Punzi, G; Pursley, J; Rademacker, J; Rahaman, A; Ramakrishnan, V; Ranjan, N; Redondo, I; Reisert, B; Rekovic, V; Renton, P; Rescigno, M; Richter, S; Rimondi, F; Ristori, L; Robson, A; Rodrigo, T; Rodriguez, T; Rogers, E; Rolli, S; Roser, R; Rossi, M; Rossin, R; Roy, P; Ruiz, A; Russ, J; Rusu, V; Saarikko, H; Safonov, A; Sakumoto, W K; Saltó, O; Saltzberg, D; Santi, L; Sarkar, S; Sartori, L; Sato, K; Savoy-Navarro, A; Scheidle, T; Schlabach, P; Schmidt, A; Schmidt, E E; Schmidt, M A; Schmidt, M P; Schmitt, M; Schwarz, T; Scodellaro, L; Scott, A L; Scribano, A; Scuri, F; Sedov, A; Seidel, S; Seiya, Y; Semenov, A; Sexton-Kennedy, L; Sfyrla, A; Shalhout, S Z; Shears, T; Shepard, P F; Sherman, D; Shimojima, M; Shiraishi, S; Shochet, M; Shon, Y; Shreyber, I; Sidoti, A; Sinervo, P; Sisakyan, A; Slaughter, A J; Slaunwhite, J; Sliwa, K; Smith, J R; Snider, F D; Snihur, R; Soha, A; Somalwar, S; Sorin, V; Spalding, J; Spreitzer, T; Squillacioti, P; Stanitzki, M; St Denis, R; Stelzer, B; Stelzer-Chilton, O; Stentz, D; Strologas, J; Stuart, D; Suh, J S; Sukhanov, A; Sutherland, M; Suslov, I; Suzuki, T; Taffard, A; Takashima, R; Takeuchi, Y; Tanaka, R; Tecchio, M; Teng, P K; Terashi, K; Thom, J; Thompson, A S; Thompson, G A; Thomson, E; Tipton, P; Tiwari, V; Tkaczyk, S; Toback, D; Tokar, S; Tollefson, K; Tomura, T; Tonelli, D; Torre, S; Torretta, D; Totaro, P; Tourneur, S; Tu, Y; Turini, N; Ukegawa, F; Vallecorsa, S; van Remortel, N; Varganov, A; Vataga, E; Vázquez, F; Velev, G; Vellidis, C; Veszpremi, V; Vidal, M; Vidal, R; Vila, I; Vilar, R; Vine, T; Vogel, M; Volobouev, I; Volpi, G; Würthwein, F; Wagner, P; Wagner, R G; Wagner, R L; Wagner-Kuhr, J; Wagner, W; Wakisaka, T; Wallny, R; Wang, S M; Warburton, A; Waters, D; Weinberger, M; Wester, W C; Whitehouse, B; Whiteson, D; Wicklund, A B; Wicklund, E; Williams, G; Williams, H H; Wilson, P; Winer, B L; Wittich, P; Wolbers, S; Wolfe, C; Wright, T; Wu, X; Wynne, S M; Yagil, A; Yamamoto, K; Yamaoka, J; Yang, U K; Yang, Y C; Yao, W M; Yeh, G P; Yoh, J; Yorita, K; Yoshida, T; Yu, G B; Yu, I; Yu, S S; Yun, J C; Zanello, L; Zanetti, A; Zaw, I; Zhang, X; Zheng, Y; Zucchelli, S

2008-11-07

We report a search for the flavor-changing neutral-current decay of the top quark t-->Zq (q=u, c) in pp collisions at sqrt[s]=1.96 TeV using a data sample corresponding to an integrated luminosity of 1.9 fb(-1) collected by the CDF II detector. This decay is strongly suppressed in the standard model and an observation of a signal at the Fermilab Tevatron would be an indication of physics beyond the standard model. Using Z+ > or = 4 jet final state candidate events, with and without an identified bottom quark jet, we obtain an upper limit of B(t-->Zq) < 3.7% at 95% C.L.

46 CFR 111.05-27 - Grounded neutral alternating current systems.

Code of Federal Regulations, 2011 CFR

2011-10-01

... the ground connection, is able to withstand the maximum available fault current without damage, and... 46 Shipping 4 2011-10-01 2011-10-01 false Grounded neutral alternating current systems. 111.05-27... Grounded neutral alternating current systems. Grounded neutral and high-impedance grounded neutral...

46 CFR 111.05-27 - Grounded neutral alternating current systems.

Code of Federal Regulations, 2010 CFR

2010-10-01

... the ground connection, is able to withstand the maximum available fault current without damage, and... 46 Shipping 4 2010-10-01 2010-10-01 false Grounded neutral alternating current systems. 111.05-27... Grounded neutral alternating current systems. Grounded neutral and high-impedance grounded neutral...

Learning to (dis)like: The effect of evaluative conditioning with tastes and faces on odor valence assessed by implicit and explicit measurements.

PubMed

van den Bosch, I; van Delft, J M; de Wijk, R A; de Graaf, C; Boesveldt, S

2015-11-01

Evaluative conditioning may be an important mechanism for learning food preferences and aversions; however, in both real life and experimental settings it has not been consistently successful. The current study aimed to gain more insight into which underlying factors may contribute to a successful outcome of olfactory evaluative conditioning. Two groups of 18 participants came in on three consecutive days, and were repeatedly exposed to four novel, neutral odors (CS) coupled to varying disliked, neutral, liked, or no stimuli (taste and/or pictures, US), following a 50% reinforcement schedule, leading to 40 odor presentations per session. Liking ratings, as well as changes in the autonomic nervous system were assessed before, during and after conditioning. We were able to induce negative, but not positive, affective changes by pairing neutral odors with tastes and pictures differing in valence. Negative as well as multimodal stimuli appear to be more potent US, since they may be considered more salient. Lastly, results of the current study imply that heart rate is responsive to changes in valence of olfactory stimuli, and perhaps even more sensitive than explicit ratings of liking. Copyright © 2015 Elsevier Inc. All rights reserved.

Feedbacks of Composition and Neutral Density Changes on the Structure of the Cusp Density Anomaly

NASA Astrophysics Data System (ADS)

Brinkman, D. G.; Walterscheid, R. L.; Clemmons, J. H.

2016-12-01

The Earth's magnetospheric cusp provides direct access of energetic particles to the thermosphere. These particles produce ionization and kinetic (particle) heating of the atmosphere. The increased ionization coupled with enhanced electric fields in the cusp produces increased Joule heating and ion drag forcing. These energy inputs cause large wind and temperature changes in the cusp region. Measurements by the CHAMP satellite (460-390- km altitude) have shown strongly enhanced density in the cusp region. The Streak mission (325-123 km), on the other hand, showed a relative depletion. The atmospheric response in the cusp can be sensitive to composition and neutral density changes. In response to heating in the cusp, air of heavier mean molecular weight is brought up from lower altitudes significantly affecting pressure gradients. This opposes the effects of temperature change due to heating and in-turn affects the density and winds produced in the cusp. Also changes in neutral density change the interaction between precipitating particles and the atmosphere and thus change heating rates and ionization in the region affected by cusp precipitation. In this study we assess the sensitivity of the wind and neutral density structure in the cusp region to changes in the mean molecular weight induced by neutral dynamics via advection, and the changes in particle heating rates and ionization which result from changes in neutral density. We use a high resolution two-dimensional time-dependent nonhydrostatic nonlinear dynamical model where inputs can be systematically altered. The resolution of the model allows us to examine the complete range of cusp widths. We compare the current simulations to observations by CHAMP and Streak. Acknowledgements: This material is based upon work supported by the National Aeronautics and Space Administration under Grant: NNX16AH46G issues through the Heliophysics Supporting Research Program. This research was also supported by The Aerospace Corporation's Technical Investment program

Measurement of the antineutrino neutral-current elastic differential cross section

NASA Astrophysics Data System (ADS)

Aguilar-Arevalo, A. A.; Brown, B. C.; Bugel, L.; Cheng, G.; Church, E. D.; Conrad, J. M.; Dharmapalan, R.; Djurcic, Z.; Finley, D. A.; Ford, R.; Garcia, F. G.; Garvey, G. T.; Grange, J.; Huelsnitz, W.; Ignarra, C.; Imlay, R.; Johnson, R. A.; Karagiorgi, G.; Katori, T.; Kobilarcik, T.; Louis, W. C.; Mariani, C.; Marsh, W.; Mills, G. B.; Mirabal, J.; Moore, C. D.; Mousseau, J.; Nienaber, P.; Osmanov, B.; Pavlovic, Z.; Perevalov, D.; Polly, C. C.; Ray, H.; Roe, B. P.; Russell, A. D.; Shaevitz, M. H.; Spitz, J.; Stancu, I.; Tayloe, R.; Van de Water, R. G.; Wascko, M. O.; White, D. H.; Wickremasinghe, D. A.; Zeller, G. P.; Zimmerman, E. D.; MiniBooNE Collaboration

2015-01-01

We report the measurement of the flux-averaged antineutrino neutral current elastic scattering cross section (d σν ¯N →ν ¯N/d Q2) on CH2 by the MiniBooNE experiment using the largest sample of antineutrino neutral current elastic candidate events ever collected. The ratio of the antineutrino to neutrino neutral current elastic scattering cross sections and a ratio of the antineutrino neutral current elastic to antineutrino charged current quasielastic cross sections are also presented.

Measurement of the antineutrino neutral-current elastic differential cross section

DOE PAGES

Aguilar-Arevalo, A.  A.; Brown, B.  C.; Bugel, L.; ...

2015-01-08

We report the measurement of the flux-averaged antineutrino neutral current elastic scattering cross section (dσ ν-barN→ν-barN/dQ 2) on CH 2 by the MiniBooNE experiment using the largest sample of antineutrino neutral current elastic candidate events ever collected. The ratio of the antineutrino to neutrino neutral current elastic scattering cross sections and a ratio of the antineutrino neutral current elastic to antineutrino charged current quasi elastic cross sections are also presented.

Ions beams and ferroelectric plasma sources

NASA Astrophysics Data System (ADS)

Stepanov, Anton

Near-perfect space-charge neutralization is required for the transverse compression of high perveance ion beams for ion-beam-driven warm dense matter experiments, such as the Neutralized Drift Compression eXperiment (NDCX). Neutralization can be accomplished by introducing a plasma in the beam path, which provides free electrons that compensate the positive space charge of the ion beam. In this thesis, charge neutralization of a 40 keV, perveance-dominated Ar+ beam by a Ferroelectric Plasma Source (FEPS) is investigated. First, the parameters of the ion beam, such as divergence due to the extraction optics, charge neutralization fraction, and emittance were measured. The ion beam was propagated through the FEPS plasma, and the effects of charge neutralization were inferred from time-resolved measurements of the transverse beam profile. In addition, the dependence of FEPS plasma parameters on the configuration of the driving pulser circuit was studied to optimize pulser design. An ion accelerator was constructed that produced a 30-50 keV Ar + beam with pulse duration <300 mus and dimensionless perveance Q up to 8 x 10-4. Transverse profile measurements 33 cm downstream of the ion source showed that the dependence of beam radius on Q was consistent with space charge expansion. It was concluded that the beam was perveance-dominated with a charge neutralization fraction of approximately zero in the absence of neutralizing plasma. Since beam expansion occurred primarily due to space charge, the decrease in effective perveance due to neutralization by FEPS plasma can be inferred from the reduction in beam radius. Results on propagation of the ion beam through FEPS plasma demonstrate that after the FEPS is triggered, the beam radius decreases to its neutralized value in about 5 mus. The duration of neutralization was about 10 mus at a charging voltage VFEPS = 5.5 kV and 35 mus at VFEPS = 6.5 kV. With VFEPS = 6.5 kV, the transverse current density profile 33 cm downstream of the source had a Gaussian shape with xrms =5 mm, which corresponds to a half-angle divergence of 0.87°. The measurements show that near-perfect charge neutralization with FEPS can be attained. No loss of ion beam current was detected, indicating the absence of a neutral cloud in the region of beam propagation, which would cause beam loss to charge exchange collisions. This provides evidence in favor of using FEPS in a future Heavy Ion Fusion accelerator. The FEPS discharge was investigated based on current-voltage measurements in the pulser circuit. Different values of series resistance and storage capacitance in the pulser circuit were used. The charged particle current emitted by the FEPS into vacuum was measured from the difference in forward and return currents in the driving circuit. It was found that FEPS is an emitter of negative charge, and that electron current emission begins approximately 0.5 mus after the fast-rising high voltage pulse is applied and lasts for tens of mus. The value of the series resistance in the pulser circuit was varied to change the rise time of the voltage pulse; plasma density was expected to decrease with increasing values of resistance. However, the data showed that changing the resistance had no significant effect. The average charge emitted per shot depends strongly on the value of the storage capacitance. Lowering the capacitance from 141 nF to 47 nF resulted in a near-complete shut-off of charge emission, although the amplitude of the applied voltage pulse was as high, and rise time as short, as when high-density plasma was produced. Increasing the capacitance from 141 nF to 235 nF increased the average charge emitted per shot by a factor of 2.

Search for Production of Single Top Quarks Via tcg and tug Flavor-Changing-Neutral-Current Couplings

NASA Astrophysics Data System (ADS)

Abazov, V. M.; Abbott, B.; Abolins, M.; Acharya, B. S.; Adams, M.; Adams, T.; Aguilo, E.; Ahn, S. H.; Ahsan, M.; Alexeev, G. D.; Alkhazov, G.; Alton, A.; Alverson, G.; Alves, G. A.; Anastasoaie, M.; Ancu, L. S.; Andeen, T.; Anderson, S.; Andrieu, B.; Anzelc, M. S.; Arnoud, Y.; Arov, M.; Askew, A.; Åsman, B.; Assis Jesus, A. C. S.; Atramentov, O.; Autermann, C.; Avila, C.; Ay, C.; Badaud, F.; Baden, A.; Bagby, L.; Baldin, B.; Bandurin, D. V.; Banerjee, P.; Banerjee, S.; Barberis, E.; Barfuss, A.-F.; Bargassa, P.; Baringer, P.; Barnes, C.; Barreto, J.; Bartlett, J. F.; Bassler, U.; Bauer, D.; Beale, S.; Bean, A.; Begalli, M.; Begel, M.; Belanger-Champagne, C.; Bellantoni, L.; Bellavance, A.; Benitez, J. A.; Beri, S. B.; Bernardi, G.; Bernhard, R.; Berntzon, L.; Bertram, I.; Besançon, M.; Beuselinck, R.; Bezzubov, V. A.; Bhat, P. C.; Bhatnagar, V.; Binder, M.; Biscarat, C.; Blackler, I.; Blazey, G.; Blekman, F.; Blessing, S.; Bloch, D.; Bloom, K.; Boehnlein, A.; Boline, D.; Bolton, T. A.; Boos, E. E.; Borissov, G.; Bos, K.; Bose, T.; Brandt, A.; Brock, R.; Brooijmans, G.; Bross, A.; Brown, D.; Buchanan, N. J.; Buchholz, D.; Buehler, M.; Buescher, V.; Bunichev, V.; Burdin, S.; Burke, S.; Burnett, T. H.; Busato, E.; Buszello, C. P.; Butler, J. M.; Calfayan, P.; Calvet, S.; Cammin, J.; Caron, S.; Carvalho, W.; Casey, B. C. K.; Cason, N. M.; Castilla-Valdez, H.; Chakrabarti, S.; Chakraborty, D.; Chan, K.; Chan, K. M.; Chandra, A.; Charles, F.; Cheu, E.; Chevallier, F.; Cho, D. K.; Choi, S.; Choudhary, B.; Christofek, L.; Christoudias, T.; Claes, D.; Clément, B.; Clément, C.; Coadou, Y.; Cooke, M.; Cooper, W. E.; Corcoran, M.; Couderc, F.; Cousinou, M.-C.; Cox, B.; Crépé-Renaudin, S.; Cutts, D.; Ćwiok, M.; da Motta, H.; Das, A.; Davies, B.; Davies, G.; de, K.; de Jong, P.; de Jong, S. J.; de La Cruz-Burelo, E.; de Oliveira Martins, C.; Degenhardt, J. D.; Déliot, F.; Demarteau, M.; Demina, R.; Denisov, D.; Denisov, S. P.; Desai, S.; Diehl, H. T.; Diesburg, M.; Doidge, M.; Dominguez, A.; Dong, H.; Dudko, L. V.; Duflot, L.; Dugad, S. R.; Duggan, D.; Duperrin, A.; Dyer, J.; Dyshkant, A.; Eads, M.; Edmunds, D.; Ellison, J.; Elvira, V. D.; Enari, Y.; Eno, S.; Ermolov, P.; Evans, H.; Evdokimov, A.; Evdokimov, V. N.; Ferapontov, A. V.; Ferbel, T.; Fiedler, F.; Filthaut, F.; Fisher, W.; Fisk, H. E.; Ford, M.; Fortner, M.; Fox, H.; Fu, S.; Fuess, S.; Gadfort, T.; Galea, C. F.; Gallas, E.; Galyaev, E.; Garcia, C.; Garcia-Bellido, A.; Gavrilov, V.; Gay, P.; Geist, W.; Gelé, D.; Gerber, C. E.; Gershtein, Y.; Gillberg, D.; Ginther, G.; Gollub, N.; Gómez, B.; Goussiou, A.; Grannis, P. D.; Greenlee, H.; Greenwood, Z. D.; Gregores, E. M.; Grenier, G.; Gris, Ph.; Grivaz, J.-F.; Grohsjean, A.; Grünendahl, S.; Grünewald, M. W.; Guo, F.; Guo, J.; Gutierrez, G.; Gutierrez, P.; Haas, A.; Hadley, N. J.; Haefner, P.; Hagopian, S.; Haley, J.; Hall, I.; Hall, R. E.; Han, L.; Hanagaki, K.; Hansson, P.; Harder, K.; Harel, A.; Harrington, R.; Hauptman, J. M.; Hauser, R.; Hays, J.; Hebbeker, T.; Hedin, D.; Hegeman, J. G.; Heinmiller, J. M.; Heinson, A. P.; Heintz, U.; Hensel, C.; Herner, K.; Hesketh, G.; Hildreth, M. D.; Hirosky, R.; Hobbs, J. D.; Hoeneisen, B.; Hoeth, H.; Hohlfeld, M.; Hong, S. J.; Hooper, R.; Houben, P.; Hu, Y.; Hubacek, Z.; Hynek, V.; Iashvili, I.; Illingworth, R.; Ito, A. S.; Jabeen, S.; Jaffré, M.; Jain, S.; Jakobs, K.; Jarvis, C.; Jenkins, A.; Jesik, R.; Johns, K.; Johnson, C.; Johnson, M.; Jonckheere, A.; Jonsson, P.; Juste, A.; Käfer, D.; Kahn, S.; Kajfasz, E.; Kalinin, A. M.; Kalk, J. M.; Kalk, J. R.; Kappler, S.; Karmanov, D.; Kasper, J.; Kasper, P.; Katsanos, I.; Kau, D.; Kaur, R.; Kehoe, R.; Kermiche, S.; Khalatyan, N.; Khanov, A.; Kharchilava, A.; Kharzheev, Y. M.; Khatidze, D.; Kim, H.; Kim, T. J.; Kirby, M. H.; Klima, B.; Kohli, J. M.; Konrath, J.-P.; Kopal, M.; Korablev, V. M.; Kotcher, J.; Kothari, B.; Koubarovsky, A.; Kozelov, A. V.; Krop, D.; Kryemadhi, A.; Kuhl, T.; Kumar, A.; Kunori, S.; Kupco, A.; Kurča, T.; Kvita, J.; Lam, D.; Lammers, S.; Landsberg, G.; Lazoflores, J.; Lebrun, P.; Lee, W. M.; Leflat, A.; Lehner, F.; Lesne, V.; Leveque, J.; Lewis, P.; Li, J.; Li, L.; Li, Q. Z.; Lietti, S. M.; Lima, J. G. R.; Lincoln, D.; Linnemann, J.; Lipaev, V. V.; Lipton, R.; Liu, Z.; Lobo, L.; Lobodenko, A.; Lokajicek, M.; Lounis, A.; Love, P.; Lubatti, H. J.; Lynker, M.; Lyon, A. L.; Maciel, A. K. A.; Madaras, R. J.; Mättig, P.; Magass, C.; Magerkurth, A.; Makovec, N.; Mal, P. K.; Malbouisson, H. B.; Malik, S.; Malyshev, V. L.; Mao, H. S.; Maravin, Y.; Martin, B.; McCarthy, R.; Melnitchouk, A.; Mendes, A.; Mendoza, L.; Mercadante, P. G.; Merkin, M.; Merritt, K. W.; Meyer, A.; Meyer, J.; Michaut, M.; Miettinen, H.; Millet, T.; Mitrevski, J.; Molina, J.; Mommsen, R. K.; Mondal, N. K.; Monk, J.; Moore, R. W.; Moulik, T.; Muanza, G. S.; Mulders, M.; Mulhearn, M.; Mundal, O.; Mundim, L.; Nagy, E.; Naimuddin, M.; Narain, M.; Naumann, N. A.; Neal, H. A.; Negret, J. P.; Neustroev, P.; Nilsen, H.; Noeding, C.; Nomerotski, A.; Novaes, S. F.; Nunnemann, T.; O'Dell, V.; O'Neil, D. C.; Obrant, G.; Ochando, C.; Oguri, V.; Oliveira, N.; Onoprienko, D.; Oshima, N.; Osta, J.; Otec, R.; Otero Y Garzón, G. J.; Owen, M.; Padley, P.; Pangilinan, M.; Parashar, N.; Park, S.-J.; Park, S. K.; Parsons, J.; Partridge, R.; Parua, N.; Patwa, A.; Pawloski, G.; Perea, P. M.; Perfilov, M.; Peters, K.; Peters, Y.; Pétroff, P.; Petteni, M.; Piegaia, R.; Piper, J.; Pleier, M.-A.; Podesta-Lerma, P. L. M.; Podstavkov, V. M.; Pogorelov, Y.; Pol, M.-E.; Pompoš, A.; Pope, B. G.; Popov, A. V.; Potter, C.; Prado da Silva, W. L.; Prosper, H. B.; Protopopescu, S.; Qian, J.; Quadt, A.; Quinn, B.; Rangel, M. S.; Rani, K. J.; Ranjan, K.; Ratoff, P. N.; Renkel, P.; Reucroft, S.; Rijssenbeek, M.; Ripp-Baudot, I.; Rizatdinova, F.; Robinson, S.; Rodrigues, R. F.; Royon, C.; Rubinov, P.; Ruchti, R.; Sajot, G.; Sánchez-Hernández, A.; Sanders, M. P.; Santoro, A.; Savage, G.; Sawyer, L.; Scanlon, T.; Schaile, D.; Schamberger, R. D.; Scheglov, Y.; Schellman, H.; Schieferdecker, P.; Schmitt, C.; Schwanenberger, C.; Schwartzman, A.; Schwienhorst, R.; Sekaric, J.; Sengupta, S.; Severini, H.; Shabalina, E.; Shamim, M.; Shary, V.; Shchukin, A. A.; Shivpuri, R. K.; Shpakov, D.; Siccardi, V.; Sidwell, R. A.; Simak, V.; Sirotenko, V.; Skubic, P.; Slattery, P.; Smirnov, D.; Smith, R. P.; Snow, G. R.; Snow, J.; Snyder, S.; Söldner-Rembold, S.; Sonnenschein, L.; Sopczak, A.; Sosebee, M.; Soustruznik, K.; Souza, M.; Spurlock, B.; Stark, J.; Steele, J.; Stolin, V.; Stone, A.; Stoyanova, D. A.; Strandberg, J.; Strandberg, S.; Strang, M. A.; Strauss, M.; Ströhmer, R.; Strom, D.; Strovink, M.; Stutte, L.; Sumowidagdo, S.; Svoisky, P.; Sznajder, A.; Talby, M.; Tamburello, P.; Taylor, W.; Telford, P.; Temple, J.; Tiller, B.; Tissandier, F.; Titov, M.; Tokmenin, V. V.; Tomoto, M.; Toole, T.; Torchiani, I.; Trefzger, T.; Trincaz-Duvoid, S.; Tsybychev, D.; Tuchming, B.; Tully, C.; Tuts, P. M.; Unalan, R.; Uvarov, L.; Uvarov, S.; Uzunyan, S.; Vachon, B.; van den Berg, P. J.; van Eijk, B.; van Kooten, R.; van Leeuwen, W. M.; Varelas, N.; Varnes, E. W.; Vartapetian, A.; Vasilyev, I. A.; Vaupel, M.; Verdier, P.; Vertogradov, L. S.; Verzocchi, M.; Villeneuve-Seguier, F.; Vint, P.; Vlimant, J.-R.; von Toerne, E.; Voutilainen, M.; Vreeswijk, M.; Wahl, H. D.; Wang, L.; Wang, M. H. L. S.; Warchol, J.; Watts, G.; Wayne, M.; Weber, G.; Weber, M.; Weerts, H.; Wenger, A.; Wermes, N.; Wetstein, M.; White, A.; Wicke, D.; Wilson, G. W.; Wimpenny, S. J.; Wobisch, M.; Wood, D. R.; Wyatt, T. R.; Xie, Y.; Yacoob, S.; Yamada, R.; Yan, M.; Yasuda, T.; Yatsunenko, Y. A.; Yip, K.; Yoo, H. D.; Youn, S. W.; Yu, C.; Yu, J.; Yurkewicz, A.; Zatserklyaniy, A.; Zeitnitz, C.; Zhang, D.; Zhao, T.; Zhou, B.; Zhu, J.; Zielinski, M.; Zieminska, D.; Zieminski, A.; Zutshi, V.; Zverev, E. G.

2007-11-01

We search for the production of single top quarks via flavor-changing-neutral-current couplings of a gluon to the top quark and a charm (c) or up (u) quark. We analyze 230pb-1 of lepton+jets data from pp¯ collisions at a center of mass energy of 1.96 TeV collected by the D0 detector at the Fermilab Tevatron Collider. We observe no significant deviation from standard model predictions, and hence set upper limits on the anomalous coupling parameters κgc/Λ and κgu/Λ, where κg define the strength of tcg and tug couplings, and Λ defines the scale of new physics. The limits at 95% C.L. are κgc/Λ<0.15TeV-1 and κgu/Λ<0.037TeV-1.

Real Time Computer Control of Neutral Beam Energy and Current During a DIII-D Tokamak Shot

NASA Astrophysics Data System (ADS)

Pawley, C. J.; Pace, D. C.; Rauch, J. M.; Scoville, J. T.

2017-10-01

A new control system has been implemented on DIII-D neutral beams which has been used during the 2016 and 2017 experimental campaign to directly change the beam acceleration voltage (V) and beam current (I) by the Plasma Control System (PCS) during a shot. Small changes in the beam voltage of 1-2 kV can be made in 1 msec or larger changes of up to 20kV in 0.5 seconds. The beam current can be modified by as much as +/-20% at a fixed beam voltage. Since both can be independently and simultaneously changed it is possible to change beam power (IV) at fixed voltage, keep constant power while sweeping beam voltage, or to maintain minimum beam divergence during a beam voltage sweep by changing I simultaneously to keep a constant beam perveance. The limitations of the variability will be presented with required changes in equipment to extend either the speed or range of the controls. Some of the effects on fast ion plasma instabilities or other plasma mode changes made possible by this control will also be presented (see also D.C. Pace, this conference). Design and changes to the control system was performed under General Atomics Internal Research and Development support, while plasma experiments on DIII-D were supported in part by the US Department of Energy under Award No. DE-FC02-04ER54698.

A case study of magnetotail current sheet disruption and diversion

NASA Technical Reports Server (NTRS)

Lui, A. T. Y.; Lopez, R. E.; Krimigis, S. M.; Mcentire, R. W.; Zanetti, L. J.

1988-01-01

On June 1, 1985 the AMPTE/CCE spacecraft (at a geocentric distance of about 8.8 earth radii at the midnight neutral sheet region) observed a dispersionless energetic particle injection and an increase in magnetic field magnitude, which are features commonly attributed to disruption of the near-earth cross-tail current sheet during substorm expansion onsets. An analysis based on high time-resolution measurements from the magnetometer and the energetic particle detector indicates that the current sheet disruption region exhibited localized (less than 1 earth radius) and transient (less than 1 min) particle intensity enhancements, accompanied by complex magnetic field changes with occasional development of a southward magnetic field component. Similar features are seen in other current disruption/diversion events observed by the CCE. The present analysis suggests that the current disruption region is quite turbulent, similar to laboratory experiments on current sheet disruption, with signatures unlike those expected from an X-type neutral line configuration. No clear indication of periodicity in any magnetic field parameter is discernible for this current disruption event.

Conserved stem fragment from H3 influenza hemagglutinin elicits cross-clade neutralizing antibodies through stalk-targeted blocking of conformational change during membrane fusion.

PubMed

Gong, Xin; Yin, He; Shi, Yuhua; Guan, Shanshan; He, Xiaoqiu; Yang, Lan; Yu, Yongjiao; Kuai, Ziyu; Jiang, Chunlai; Kong, Wei; Wang, Song; Shan, Yaming

2016-04-01

Currently available influenza vaccines typically fail to elicit/boost broadly neutralizing antibodies due to the mutability of virus sequences and conformational changes during protective immunity, thereby limiting their efficacy. This problem needs to be addressed by further understanding the mechanisms of neutralization and finding the desired neutralizing site during membrane fusion. This study specifically focused on viruses of the H3N2 subtype, which have persisted as a principal source of influenza-related morbidity and mortality in humans since the 1968 influenza pandemic. Through sequence alignment and epitope prediction, a series of highly conserved stem fragments (spanning 47 years) were found and coupled to the Keyhole Limpet Hemocyanin (KLH) protein. By application of a combinatorial display library and crystal structure modeling, a stem fragment immunogen, located at the turning point of the HA neck undergoing conformational change during membrane fusion with both B- and T-cell epitopes, was identified. After synthesis of the optimal stem fragment using a multiple antigen peptide (MAP) system, strong humoral immune responses and cross-clade neutralizing activities against strains from the H3 subtype of group 2 influenza viruses after animal immunizations were observed. By detection of nuclear protein immunofluorescence with acid bypass treatment, antisera raised against MAP4 immunogens of the stem fragment showed the potential to inhibit the conformational change of HA in stem-targeted virus neutralization. The identification of this conserved stem fragment provides great potential for exploitation of this site of vulnerability in therapeutic and vaccine design. Copyright © 2016 European Federation of Immunological Societies. Published by Elsevier B.V. All rights reserved.

Search for production of single top quarks via tcg and tug flavor-changing-neutral-current couplings.

PubMed

Abazov, V M; Abbott, B; Abolins, M; Acharya, B S; Adams, M; Adams, T; Aguilo, E; Ahn, S H; Ahsan, M; Alexeev, G D; Alkhazov, G; Alton, A; Alverson, G; Alves, G A; Anastasoaie, M; Ancu, L S; Andeen, T; Anderson, S; Andrieu, B; Anzelc, M S; Arnoud, Y; Arov, M; Askew, A; Asman, B; Assis Jesus, A C S; Atramentov, O; Autermann, C; Avila, C; Ay, C; Badaud, F; Baden, A; Bagby, L; Baldin, B; Bandurin, D V; Banerjee, P; Banerjee, S; Barberis, E; Barfuss, A-F; Bargassa, P; Baringer, P; Barnes, C; Barreto, J; Bartlett, J F; Bassler, U; Bauer, D; Beale, S; Bean, A; Begalli, M; Begel, M; Belanger-Champagne, C; Bellantoni, L; Bellavance, A; Benitez, J A; Beri, S B; Bernardi, G; Bernhard, R; Berntzon, L; Bertram, I; Besançon, M; Beuselinck, R; Bezzubov, V A; Bhat, P C; Bhatnagar, V; Binder, M; Biscarat, C; Blackler, I; Blazey, G; Blekman, F; Blessing, S; Bloch, D; Bloom, K; Boehnlein, A; Boline, D; Bolton, T A; Boos, E E; Borissov, G; Bos, K; Bose, T; Brandt, A; Brock, R; Brooijmans, G; Bross, A; Brown, D; Buchanan, N J; Buchholz, D; Buehler, M; Buescher, V; Bunichev, V; Burdin, S; Burke, S; Burnett, T H; Busato, E; Buszello, C P; Butler, J M; Calfayan, P; Calvet, S; Cammin, J; Caron, S; Carvalho, W; Casey, B C K; Cason, N M; Castilla-Valdez, H; Chakrabarti, S; Chakraborty, D; Chan, K; Chan, K M; Chandra, A; Charles, F; Cheu, E; Chevallier, F; Cho, D K; Choi, S; Choudhary, B; Christofek, L; Christoudias, T; Claes, D; Clément, B; Clément, C; Coadou, Y; Cooke, M; Cooper, W E; Corcoran, M; Couderc, F; Cousinou, M-C; Cox, B; Crépé-Renaudin, S; Cutts, D; Cwiok, M; da Motta, H; Das, A; Davies, B; Davies, G; De, K; de Jong, P; de Jong, S J; De La Cruz-Burelo, E; De Oliveira Martins, C; Degenhardt, J D; Déliot, F; Demarteau, M; Demina, R; Denisov, D; Denisov, S P; Desai, S; Diehl, H T; Diesburg, M; Doidge, M; Dominguez, A; Dong, H; Dudko, L V; Duflot, L; Dugad, S R; Duggan, D; Duperrin, A; Dyer, J; Dyshkant, A; Eads, M; Edmunds, D; Ellison, J; Elvira, V D; Enari, Y; Eno, S; Ermolov, P; Evans, H; Evdokimov, A; Evdokimov, V N; Ferapontov, A V; Ferbel, T; Fiedler, F; Filthaut, F; Fisher, W; Fisk, H E; Ford, M; Fortner, M; Fox, H; Fu, S; Fuess, S; Gadfort, T; Galea, C F; Gallas, E; Galyaev, E; Garcia, C; Garcia-Bellido, A; Gavrilov, V; Gay, P; Geist, W; Gelé, D; Gerber, C E; Gershtein, Y; Gillberg, D; Ginther, G; Gollub, N; Gómez, B; Goussiou, A; Grannis, P D; Greenlee, H; Greenwood, Z D; Gregores, E M; Grenier, G; Gris, Ph; Grivaz, J-F; Grohsjean, A; Grünendahl, S; Grünewald, M W; Guo, F; Guo, J; Gutierrez, G; Gutierrez, P; Haas, A; Hadley, N J; Haefner, P; Hagopian, S; Haley, J; Hall, I; Hall, R E; Han, L; Hanagaki, K; Hansson, P; Harder, K; Harel, A; Harrington, R; Hauptman, J M; Hauser, R; Hays, J; Hebbeker, T; Hedin, D; Hegeman, J G; Heinmiller, J M; Heinson, A P; Heintz, U; Hensel, C; Herner, K; Hesketh, G; Hildreth, M D; Hirosky, R; Hobbs, J D; Hoeneisen, B; Hoeth, H; Hohlfeld, M; Hong, S J; Hooper, R; Houben, P; Hu, Y; Hubacek, Z; Hynek, V; Iashvili, I; Illingworth, R; Ito, A S; Jabeen, S; Jaffré, M; Jain, S; Jakobs, K; Jarvis, C; Jenkins, A; Jesik, R; Johns, K; Johnson, C; Johnson, M; Jonckheere, A; Jonsson, P; Juste, A; Käfer, D; Kahn, S; Kajfasz, E; Kalinin, A M; Kalk, J M; Kalk, J R; Kappler, S; Karmanov, D; Kasper, J; Kasper, P; Katsanos, I; Kau, D; Kaur, R; Kehoe, R; Kermiche, S; Khalatyan, N; Khanov, A; Kharchilava, A; Kharzheev, Y M; Khatidze, D; Kim, H; Kim, T J; Kirby, M H; Klima, B; Kohli, J M; Konrath, J-P; Kopal, M; Korablev, V M; Kotcher, J; Kothari, B; Koubarovsky, A; Kozelov, A V; Krop, D; Kryemadhi, A; Kuhl, T; Kumar, A; Kunori, S; Kupco, A; Kurca, T; Kvita, J; Lam, D; Lammers, S; Landsberg, G; Lazoflores, J; Lebrun, P; Lee, W M; Leflat, A; Lehner, F; Lesne, V; Leveque, J; Lewis, P; Li, J; Li, L; Li, Q Z; Lietti, S M; Lima, J G R; Lincoln, D; Linnemann, J; Lipaev, V V; Lipton, R; Liu, Z; Lobo, L; Lobodenko, A; Lokajicek, M; Lounis, A; Love, P; Lubatti, H J; Lynker, M; Lyon, A L; Maciel, A K A; Madaras, R J; Mättig, P; Magass, C; Magerkurth, A; Makovec, N; Mal, P K; Malbouisson, H B; Malik, S; Malyshev, V L; Mao, H S; Maravin, Y; Martin, B; McCarthy, R; Melnitchouk, A; Mendes, A; Mendoza, L; Mercadante, P G; Merkin, M; Merritt, K W; Meyer, A; Meyer, J; Michaut, M; Miettinen, H; Millet, T; Mitrevski, J; Molina, J; Mommsen, R K; Mondal, N K; Monk, J; Moore, R W; Moulik, T; Muanza, G S; Mulders, M; Mulhearn, M; Mundal, O; Mundim, L; Nagy, E; Naimuddin, M; Narain, M; Naumann, N A; Neal, H A; Negret, J P; Neustroev, P; Nilsen, H; Noeding, C; Nomerotski, A; Novaes, S F; Nunnemann, T; O'Dell, V; O'Neil, D C; Obrant, G; Ochando, C; Oguri, V; Oliveira, N; Onoprienko, D; Oshima, N; Osta, J; Otec, R; Otero Y Garzón, G J; Owen, M; Padley, P; Pangilinan, M; Parashar, N; Park, S-J; Park, S K; Parsons, J; Partridge, R; Parua, N; Patwa, A; Pawloski, G; Perea, P M; Perfilov, M; Peters, K; Peters, Y; Pétroff, P; Petteni, M; Piegaia, R; Piper, J; Pleier, M-A; Podesta-Lerma, P L M; Podstavkov, V M; Pogorelov, Y; Pol, M-E; Pompos, A; Pope, B G; Popov, A V; Potter, C; Prado da Silva, W L; Prosper, H B; Protopopescu, S; Qian, J; Quadt, A; Quinn, B; Rangel, M S; Rani, K J; Ranjan, K; Ratoff, P N; Renkel, P; Reucroft, S; Rijssenbeek, M; Ripp-Baudot, I; Rizatdinova, F; Robinson, S; Rodrigues, R F; Royon, C; Rubinov, P; Ruchti, R; Sajot, G; Sánchez-Hernández, A; Sanders, M P; Santoro, A; Savage, G; Sawyer, L; Scanlon, T; Schaile, D; Schamberger, R D; Scheglov, Y; Schellman, H; Schieferdecker, P; Schmitt, C; Schwanenberger, C; Schwartzman, A; Schwienhorst, R; Sekaric, J; Sengupta, S; Severini, H; Shabalina, E; Shamim, M; Shary, V; Shchukin, A A; Shivpuri, R K; Shpakov, D; Siccardi, V; Sidwell, R A; Simak, V; Sirotenko, V; Skubic, P; Slattery, P; Smirnov, D; Smith, R P; Snow, G R; Snow, J; Snyder, S; Söldner-Rembold, S; Sonnenschein, L; Sopczak, A; Sosebee, M; Soustruznik, K; Souza, M; Spurlock, B; Stark, J; Steele, J; Stolin, V; Stone, A; Stoyanova, D A; Strandberg, J; Strandberg, S; Strang, M A; Strauss, M; Ströhmer, R; Strom, D; Strovink, M; Stutte, L; Sumowidagdo, S; Svoisky, P; Sznajder, A; Talby, M; Tamburello, P; Taylor, W; Telford, P; Temple, J; Tiller, B; Tissandier, F; Titov, M; Tokmenin, V V; Tomoto, M; Toole, T; Torchiani, I; Trefzger, T; Trincaz-Duvoid, S; Tsybychev, D; Tuchming, B; Tully, C; Tuts, P M; Unalan, R; Uvarov, L; Uvarov, S; Uzunyan, S; Vachon, B; van den Berg, P J; van Eijk, B; Van Kooten, R; van Leeuwen, W M; Varelas, N; Varnes, E W; Vartapetian, A; Vasilyev, I A; Vaupel, M; Verdier, P; Vertogradov, L S; Verzocchi, M; Villeneuve-Seguier, F; Vint, P; Vlimant, J-R; Von Toerne, E; Voutilainen, M; Vreeswijk, M; Wahl, H D; Wang, L; Wang, M H L S; Warchol, J; Watts, G; Wayne, M; Weber, G; Weber, M; Weerts, H; Wenger, A; Wermes, N; Wetstein, M; White, A; Wicke, D; Wilson, G W; Wimpenny, S J; Wobisch, M; Wood, D R; Wyatt, T R; Xie, Y; Yacoob, S; Yamada, R; Yan, M; Yasuda, T; Yatsunenko, Y A; Yip, K; Yoo, H D; Youn, S W; Yu, C; Yu, J; Yurkewicz, A; Zatserklyaniy, A; Zeitnitz, C; Zhang, D; Zhao, T; Zhou, B; Zhu, J; Zielinski, M; Zieminska, D; Zieminski, A; Zutshi, V; Zverev, E G

2007-11-09

We search for the production of single top quarks via flavor-changing-neutral-current couplings of a gluon to the top quark and a charm (c) or up (u) quark. We analyze 230 pb{-1} of lepton+jets data from pp[over] collisions at a center of mass energy of 1.96 TeV collected by the D0 detector at the Fermilab Tevatron Collider. We observe no significant deviation from standard model predictions, and hence set upper limits on the anomalous coupling parameters kappa{g}{c}/Lambda and kappa{g}{u}/Lambda, where kappa{g} define the strength of tcg and tug couplings, and Lambda defines the scale of new physics. The limits at 95% C.L. are kappa{g}{c}/Lambda<0.15 TeV-1 and kappa{g}{u}/Lambda<0.037 TeV-1.

Saturn Ring

NASA Image and Video Library

2007-12-12

Like Earth, Saturn has an invisible ring of energetic ions trapped in its magnetic field. This feature is known as a "ring current." This ring current has been imaged with a special camera on Cassini sensitive to energetic neutral atoms. This is a false color map of the intensity of the energetic neutral atoms emitted from the ring current through a processed called charged exchange. In this process a trapped energetic ion steals and electron from cold gas atoms and becomes neutral and escapes the magnetic field. The Cassini Magnetospheric Imaging Instrument's ion and neutral camera records the intensity of the escaping particles, which provides a map of the ring current. In this image, the colors represent the intensity of the neutral emission, which is a reflection of the trapped ions. This "ring" is much farther from Saturn (roughly five times farther) than Saturn's famous icy rings. Red in the image represents the higher intensity of the particles, while blue is less intense. Saturn's ring current had not been mapped before on a global scale, only "snippets" or areas were mapped previously but not in this detail. This instrument allows scientists to produce movies (see PIA10083) that show how this ring changes over time. These movies reveal a dynamic system, which is usually not as uniform as depicted in this image. The ring current is doughnut shaped but in some instances it appears as if someone took a bite out of it. This image was obtained on March 19, 2007, at a latitude of about 54.5 degrees and radial distance 1.5 million kilometres (920,000 miles). Saturn is at the center, and the dotted circles represent the orbits of the moon's Rhea and Titan. The Z axis points parallel to Saturn's spin axis, the X axis points roughly sunward in the sun-spin axis plane, and the Y axis completes the system, pointing roughly toward dusk. The ion and neutral camera's field of view is marked by the white line and accounts for the cut-off of the image on the left. The image is an average of the activity over a (roughly) 3-hour period. http://photojournal.jpl.nasa.gov/catalog/PIA10094

Neutral-current x-distributions

DOE R&D Accomplishments Database

Friedman, J. I.; Kendall, H. W.; Bogert, D.; Burnstein, R.; Fisk, R.; Fuess, S.; Bofill, J.; Busza, W.; Eldridge, T.; Abolins, M.; Brock, R.; et al.

1984-06-01

The role of the semi leptonic neutral current interaction as a probe of nucleon structure is examined. Previous measurements of neutral current x-distributions are reviewed, and new results from the Fermilab - MIT - MSU collaboration are presented.

Analysis and Countermeasure Study on DC Bias of Main Transformer in a City

NASA Astrophysics Data System (ADS)

Wang, PengChao; Wang, Hongtao; Song, Xinpu; Gu, Jun; Liu, yong; Wu, weili

2017-07-01

According to the December 2015 Guohua Beijing thermal power transformer DC magnetic bias phenomenon, the monitoring data of 24 hours of direct current is analyzed. We find that the maximum DC current is up to 25 and is about 30s for the trend cycle, on this basis, then, of the geomagnetic storm HVDC and subway operation causes comparison of the mechanism, and make a comprehensive analysis of the thermal power plant’s geographical location, surrounding environment and electrical contact etc.. The results show that the main reason for the DC bias of Guohua thermal power transformer is the operation of the subway, and the change of the DC bias current is periodic. Finally, of Guohua thermal power transformer DC magnetic bias control method is studied, the simulation results show that the method of using neutral point with small resistance or capacitance can effectively inhibit the main transformer neutral point current.

Preliminary measurements of plasma fluctuations in an 8-cm mercury ion thruster

NASA Technical Reports Server (NTRS)

Serafini, J. S.; Nakanishi, S.

1975-01-01

The rms magnitude, spectra, and cross correlations for the fluctuations in the beam current, the neutralizer keeper current, and the discharge current and voltage were measured for an 8-cm diameter, dished grid ion thruster for a beam current of 72 milliamps. The ratio of the rms magnitude of the fluctuations to the time-mean neutralizer keeper current was found to depend significantly on the neutralizer time-mean keeper current, the flow rate, and keeper hold diameter. The maxima of the spectra of the beam current fluctuations did not depend on the discharge fluctuations. It was found that: (1) the discharge current fluctuations do not directly contribute to the beam current fluctuations; and (2) the neutralizer contributions to the beam fluctuations are small (for good neutralizer-to-beam coupling) but not negligible and appear mostly in the higher frequency range measured.

Modeling of the coupled magnetospheric and neutral wind dynamos

NASA Technical Reports Server (NTRS)

Thayer, Jeffrey P.

1994-01-01

This report summarizes the progress made in the first year of NASA Grant No. NAGW-3508 entitled 'Modeling of the Coupled Magnetospheric and Neutral Wind Dynamos.' The approach taken has been to impose magnetospheric boundary conditions with either pure voltage or current characteristics and solve the neutral wind dynamo equation under these conditions. The imposed boundary conditions determine whether the neutral wind dynamo will contribute to the high-latitude current system or the electric potential. The semi-annual technical report, dated December 15, 1993, provides further detail describing the scientific and numerical approach of the project. The numerical development has progressed and the dynamo solution for the case when the magnetosphere acts as a voltage source has been evaluated completely using spectral techniques. The simulation provides the field-aligned current distribution at high latitudes due to the neutral wind dynamo. A number of geophysical conditions can be simulated to evaluate the importance of the neutral wind dynamo contribution to the field-aligned current system. On average, field-aligned currents generated by the neutral wind dynamo contributed as much as 30 percent to the large-scale field-aligned current system driven by the magnetosphere. A term analysis of the high-latitude neutral wind dynamo equation describing the field aligned current distribution has also been developed to illustrate the important contributing factors involved in the process. The case describing the neutral dynamo response for a magnetosphere acting as a pure current generator requires the existing spectral code to be extended to a pseudo-spectral method and is currently under development.

Transportation of high-current ion and electron beams in the accelerator drift gap in the presence of an additional electron background

DOE Office of Scientific and Technical Information (OSTI.GOV)

Karas’, V. I., E-mail: karas@kipt.kharkov.ua; Kornilov, E. A.; Manuilenko, O. V.

2015-12-15

The dynamics of a high-current ion beam propagating in the drift gap of a linear induction accelerator with collective focusing is studied using 3D numerical simulations in the framework of the full system of the Vlasov–Maxwell equations (code KARAT). The ion beam is neutralized by a comoving electron beam in the current density and, partially, in space charge, since the velocities of electrons and ions differ substantially. The dynamics of the high-current ion beam is investigated for different versions of additional neutralization of its space charge. It is established that, for a given configuration of the magnetic field and inmore » the presence of a specially programmed injection of additional electrons from the boundary opposite to the ion injection boundary, the angular divergence of the ion beam almost vanishes, whereas the current of the ion beam at the exit from the accelerator drift gap changes insignificantly and the beam remains almost monoenergetic.« less

Transportation of high-current ion and electron beams in the accelerator drift gap in the presence of an additional electron background

NASA Astrophysics Data System (ADS)

Karas', V. I.; Kornilov, E. A.; Manuilenko, O. V.; Tarakanov, V. P.; Fedorovskaya, O. V.

2015-12-01

The dynamics of a high-current ion beam propagating in the drift gap of a linear induction accelerator with collective focusing is studied using 3D numerical simulations in the framework of the full system of the Vlasov-Maxwell equations (code KARAT). The ion beam is neutralized by a comoving electron beam in the current density and, partially, in space charge, since the velocities of electrons and ions differ substantially. The dynamics of the high-current ion beam is investigated for different versions of additional neutralization of its space charge. It is established that, for a given configuration of the magnetic field and in the presence of a specially programmed injection of additional electrons from the boundary opposite to the ion injection boundary, the angular divergence of the ion beam almost vanishes, whereas the current of the ion beam at the exit from the accelerator drift gap changes insignificantly and the beam remains almost monoenergetic.

Application of scenario-neutral methods to quantify impacts of climate change on water resources in East Africa

NASA Astrophysics Data System (ADS)

Ascott, M.; Macdonald, D.; Lapworth, D.; Tindimugaya, C.

2017-12-01

Quantification of the impact of climate change on water resources is essential for future resource planning. Unfortunately, climate change impact studies in African regions are often hindered by the extent in variability in future rainfall predictions, which also diverge from current drying trends. To overcome this limitation, "scenario-neutral" methods have been developed which stress a hydrological system using a wide range of climate futures to build a "climate response surface". We developed a hydrological model and scenario-neutral framework to quantify climate change impacts on river flows in the Katonga catchment, Uganda. Using the lumped catchment model GR4J, an acceptable calibration to historic daily flows (1966 - 2010, NSE = 0.69) was achieved. Using a delta change approach, we then systematically changed rainfall and PET inputs to develop response surfaces for key metrics, developed with Ugandan water resources planners (e.g. Q5, Q95). Scenarios from the CMIP5 models for 2030s and 2050s were then overlain on the response surface. The CMIP5 scenarios show consistent increases in temperature but large variability in rainfall increases, which results in substantial variability in increases in river flows. The developed response surface covers a wide range of climate futures beyond the CMIP5 projections, and can help water resources planners understand the sensitivity of water resource systems to future changes. When future climate scenarios are available, these can be directly overlain on the response surface without the need to re-run the hydrological model. Further work will consider using scenario-neutral approaches in more complex, semi-distributed models (e.g. SWAT), and will consider land use and socioeconomic change.

Thermal neutral format based on the step technology

NASA Technical Reports Server (NTRS)

Almazan, P. Planas; Legal, J. L.

1995-01-01

The exchange of models is one of the most serious problems currently encountered in the practice of spacecraft thermal analysis. Essentially, the problem originates in the diversity of computing environments that are used across different sites, and the consequent proliferation of native tool formats. Furthermore, increasing pressure to reduce the development's life cycle time has originated a growing interest in the so-called spacecraft concurrent engineering. In this context, the realization of the interdependencies between different disciplines and the proper communication between them become critical issues. The use of a neutral format represents a step forward in addressing these problems. Such a means of communication is adopted by consensus. A neutral format is not directly tied to any specific tool and it is kept under stringent change control. Currently, most of the groups promoting exchange formats are contributing with their experience to STEP, the Standard for Exchange of Product Model Data, which is being developed under the auspices of the International Standards Organization (ISO 10303). This paper presents the different efforts made in Europe to provide the spacecraft thermal analysis community with a Thermal Neutral Format (TNF) based on STEP. Following an introduction with some background information, the paper presents the characteristics of the STEP standard. Later, the first efforts to produce a STEP Spacecraft Thermal Application Protocol are described. Finally, the paper presents the currently harmonized European activities that follow up and extend earlier work on the area.

A 13000-hour test of a mercury hollow cathode

NASA Technical Reports Server (NTRS)

Rawlin, V. K.

1973-01-01

A mercury-fed hollow cathode was tested for 12,979 hours in a bell jar at SERT 2 neutralizer operating conditions. The net electron current drawn to a collector was 0.25 ampere at average collector voltages between 21.8 and 36.7 volts. The mercury flow rate was varied from 5.6 to 30.8 equivalent milliamperes to give stable operation at the desired electrode voltages and currents. Variations with time in the neutralizer discharge characteristics were observed and hypothesized to be related to changes in the cathode orifice dimensions and the availability of electron emissive material. A facility failure caused abnormal test conditions for the last 876 hours and led to the cathode heater failure which concluded the test.

Efficacy Evaluation of Current and Future Naval Mine Warfare Neutralization Method

DTIC Science & Technology

2016-12-01

Distribution is unlimited. EFFICACY EVALUATION OF CURRENT AND FUTURE NAVAL MINE WARFARE NEUTRALIZATION METHOD by Team MIW Cohort SE311-152O...EFFICACY EVALUATION OF CURRENT AND FUTURE NAVAL MINE WARFARE NEUTRALIZATION METHOD 5. FUNDING NUMBERS 6. AUTHOR (S) Team MIW, Systems Engineering...NEUTRALIZATION METHOD Team MIW, Systems Engineering Cohort SE311-152O Submitted in partial fulfillment of the requirements for the degrees of

Electric-current Neutralization, Magnetic Shear, and Eruptive Activity in Solar Active Regions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liu, Yang; Sun, Xudong; Török, Tibor

The physical conditions that determine whether or not solar active regions (ARs) produce strong flares and coronal mass ejections (CMEs) are not yet well understood. Here, we investigate the association between electric-current neutralization, magnetic shear along polarity inversion lines (PILs), and eruptive activity in four ARs: two emerging and two well-developed ones. We find that the CME-producing ARs are characterized by a strongly non-neutralized total current, while the total current in the ARs that did not produce CMEs is almost perfectly neutralized. The difference in the PIL shear between these two groups is much less pronounced, which suggests that themore » degree of current neutralization may serve as a better proxy for assessing the ability of ARs to produce CMEs.« less

Design and simulation of control algorithms for stored energy and plasma current in non-inductive scenarios on NSTX-U

NASA Astrophysics Data System (ADS)

Boyer, Mark; Andre, Robert; Gates, David; Gerhardt, Stefan; Menard, Jonathan; Poli, Francesca

2015-11-01

One of the major goals of NSTX-U is to demonstrate non-inductive operation. To facilitate this and other program goals, the center stack has been upgraded and a second neutral beam line has been added with three sources aimed more tangentially to provide higher current drive efficiency and the ability to shape the current drive profile. While non-inductive start-up and ramp-up scenarios are being developed, initial non-inductive studies will likely rely on clamping the Ohmic coil current after the plasma current has been established inductively. In this work the ability to maintain control of stored energy and plasma current once the Ohmic coil has been clamped is explored. The six neutral beam sources and the mid-plane outer gap of the plasma are considered as actuators. System identification is done using TRANSP simulations in which the actuators are modulated around a reference shot. The resulting reduced model is used to design an optimal control law with anti-windup and a recently developed framework for closed loop simulations in TRANSP is used to test the control. Limitations due to actuator saturation are assessed and robustness to beam modulation, changes in the plasma density and confinement, and changes in density and temperature profile shapes are studied. Supported by US DOE contract DE-AC02-09CH11466.

Rapid quantification of neutral lipids and triglycerides during zebrafish embryogenesis.

PubMed

Yoganantharjah, Prusothman; Byreddy, Avinesh R; Fraher, Daniel; Puri, Munish; Gibert, Yann

2017-01-01

The zebrafish is a useful vertebrate model to study lipid metabolism. Oil Red-O (ORO) staining of zebrafish embryos, though sufficient for visualizing the localization of triglycerides, was previously inadequate to quantify neutral lipid abundance. For metabolic studies, it is crucial to be able to quantify lipids during embryogenesis. Currently no cost effective, rapid and reliable method exists to quantify the deposition of neutral lipids and triglycerides. Thin layer chromatography (TLC), gas chromatography and mass spectrometry can be used to accurately measure lipid levels, but are time consuming and costly in their use. Hence, we developed a rapid and reliable method to quantify neutral lipids and triglycerides. Zebrafish embryos were exposed to Rimonabant (Rimo) or WIN 55,212-2 mesylate (WIN), compounds previously shown to modify lipid content during zebrafish embryogenesis. Following this, ORO stain was extracted out of both the zebrafish body and yolk sac and optical density was measured to give an indication of neutral lipid and triglyceride accumulation. Embryos treated with 0.3 microM WIN resulted in increased lipid accumulation, whereas 3 microM Rimo caused a decrease in lipid accumulation during embryogenesis. TLC was performed on zebrafish bodies to validate the developed method. In addition, BODIPY free fatty acids were injected into zebrafish embryos to confirm quantification of changes in lipid content in the embryo. Previously, ORO was limited to qualitative assessment; now ORO can be used as a quantitative tool to directly determine changes in the levels of neutral lipids and triglycerides.

Observation of the Baryonic Flavor-Changing Neutral Current Decay Λ b 0 → Λµ +µ -

DOE PAGES

Aaltonen, T.

2011-11-08

The authors report the first observation of the baryonic flavor-changing neutral current decay Λ b 0 → Λµ +µ - with 24 signal events and a statistical significance of 5.8 Gaussian standard deviations. This measurement uses a pp¯ collisions data sample corresponding to 6.8 fb -1 at √s = 1.96 TeV collected by the CDF II detector at the Tevatron collider. The total and differential branching ratios for Λ b 0 → Λµ +µ - are measured. They find Β(Λ b 0 → Λµ +µ -) = [1.73 ± 0.42(stat) ± 0.55(syst)] x 10 -6. They also report the firstmore » measurement of the differential branching ratio of B s 0→φµ +µ - using 49 signal events. In addition, they report branching ratios for B +→K +µ +µ -, B 0→K 0µ +µ - and Β→ K*(892)µ +µ - decays.« less

Search for flavour-changing neutral current top-quark decays to [Formula: see text] in [Formula: see text] collision data collected with the ATLAS detector at [Formula: see text] TeV.

PubMed

Aad, G; Abbott, B; Abdallah, J; Abdinov, O; Aben, R; Abolins, M; AbouZeid, O S; Abramowicz, H; Abreu, H; Abreu, R; Abulaiti, Y; Acharya, B S; Adamczyk, L; Adams, D L; Adelman, J; Adomeit, S; Adye, T; Affolder, A A; Agatonovic-Jovin, T; Agricola, J; Aguilar-Saavedra, J A; Ahlen, S P; Ahmadov, F; Aielli, G; Akerstedt, H; Åkesson, T P A; Akimov, A V; Alberghi, G L; Albert, J; Albrand, S; Alconada Verzini, M J; Aleksa, M; Aleksandrov, I N; Alexa, C; Alexander, G; Alexopoulos, T; Alhroob, M; Alimonti, G; Alio, L; Alison, J; Alkire, S P; Allbrooke, B M M; Allport, P P; Aloisio, A; Alonso, A; Alonso, F; Alpigiani, C; Altheimer, A; Alvarez Gonzalez, B; Álvarez Piqueras, D; Alviggi, M G; Amadio, B T; Amako, K; Amaral Coutinho, Y; Amelung, C; Amidei, D; Amor Dos Santos, S P; Amorim, A; Amoroso, S; Amram, N; Amundsen, G; Anastopoulos, C; Ancu, L S; Andari, N; Andeen, T; Anders, C F; Anders, G; Anders, J K; Anderson, K J; Andreazza, A; Andrei, V; Angelidakis, S; Angelozzi, I; Anger, P; Angerami, A; Anghinolfi, F; Anisenkov, A V; Anjos, N; Annovi, A; Antonelli, M; Antonov, A; Antos, J; Anulli, F; Aoki, M; Aperio Bella, L; Arabidze, G; Arai, Y; Araque, J P; Arce, A T H; Arduh, F A; Arguin, J-F; Argyropoulos, S; Arik, M; Armbruster, A J; Arnaez, O; Arnal, V; Arnold, H; Arratia, M; Arslan, O; Artamonov, A; Artoni, G; Asai, S; Asbah, N; Ashkenazi, A; Åsman, B; Asquith, L; Assamagan, K; Astalos, R; Atkinson, M; Atlay, N B; Augsten, K; Aurousseau, M; Avolio, G; Axen, B; Ayoub, M K; Azuelos, G; Baak, M A; Baas, A E; Baca, M J; Bacci, C; Bachacou, H; Bachas, K; Backes, M; Backhaus, M; Bagiacchi, P; Bagnaia, P; Bai, Y; Bain, T; Baines, J T; Baker, O K; Baldin, E M; Balek, P; Balestri, T; Balli, F; Banas, E; Banerjee, Sw; Bannoura, A A E; Bansil, H S; Barak, L; Barberio, E L; Barberis, D; Barbero, M; Barillari, T; Barisonzi, M; Barklow, T; Barlow, N; Barnes, S L; Barnett, B M; Barnett, R M; Barnovska, Z; Baroncelli, A; Barone, G; Barr, A J; Barreiro, F; Barreiro Guimarães da Costa, J; Bartoldus, R; Barton, A E; Bartos, P; Basalaev, A; Bassalat, A; Basye, A; Bates, R L; Batista, S J; Batley, J R; Battaglia, M; Bauce, M; Bauer, F; Bawa, H S; Beacham, J B; Beattie, M D; Beau, T; Beauchemin, P H; Beccherle, R; Bechtle, P; Beck, H P; Becker, K; Becker, M; Becker, S; Beckingham, M; Becot, C; Beddall, A J; Beddall, A; Bednyakov, V A; Bee, C P; Beemster, L J; Beermann, T A; Begel, M; Behr, J K; Belanger-Champagne, C; Bell, W H; Bella, G; Bellagamba, L; Bellerive, A; Bellomo, M; Belotskiy, K; Beltramello, O; Benary, O; Benchekroun, D; Bender, M; Bendtz, K; Benekos, N; Benhammou, Y; Benhar Noccioli, E; Benitez Garcia, J A; Benjamin, D P; Bensinger, J R; Bentvelsen, S; Beresford, L; Beretta, M; Berge, D; Bergeaas Kuutmann, E; Berger, N; Berghaus, F; Beringer, J; Bernard, C; Bernard, N R; Bernius, C; Bernlochner, F U; Berry, T; Berta, P; Bertella, C; Bertoli, G; Bertolucci, F; Bertsche, C; Bertsche, D; Besana, M I; Besjes, G J; Bessidskaia Bylund, O; Bessner, M; Besson, N; Betancourt, C; Bethke, S; Bevan, A J; Bhimji, W; Bianchi, R M; Bianchini, L; Bianco, M; Biebel, O; Biedermann, D; Bieniek, S P; Biglietti, M; Bilbao De Mendizabal, J; Bilokon, H; Bindi, M; Binet, S; Bingul, A; Bini, C; Biondi, S; Black, C W; Black, J E; Black, K M; Blackburn, D; Blair, R E; Blanchard, J-B; Blanco, J E; Blazek, T; Bloch, I; Blocker, C; Blum, W; Blumenschein, U; Bobbink, G J; Bobrovnikov, V S; Bocchetta, S S; Bocci, A; Bock, C; Boehler, M; Bogaerts, J A; Bogavac, D; Bogdanchikov, A G; Bohm, C; Boisvert, V; Bold, T; Boldea, V; Boldyrev, A S; Bomben, M; Bona, M; Boonekamp, M; Borisov, A; Borissov, G; Borroni, S; Bortfeldt, J; Bortolotto, V; Bos, K; Boscherini, D; Bosman, M; Boudreau, J; Bouffard, J; Bouhova-Thacker, E V; Boumediene, D; Bourdarios, C; Bousson, N; Boveia, A; Boyd, J; Boyko, I R; Bozic, I; Bracinik, J; Brandt, A; Brandt, G; Brandt, O; Bratzler, U; Brau, B; Brau, J E; Braun, H M; Brazzale, S F; Breaden Madden, W D; Brendlinger, K; Brennan, A J; Brenner, L; Brenner, R; Bressler, S; Bristow, K; Bristow, T M; Britton, D; Britzger, D; Brochu, F M; Brock, I; Brock, R; Bronner, J; Brooijmans, G; Brooks, T; Brooks, W K; Brosamer, J; Brost, E; Brown, J; Bruckman de Renstrom, P A; Bruncko, D; Bruneliere, R; Bruni, A; Bruni, G; Bruschi, M; Bruscino, N; Bryngemark, L; Buanes, T; Buat, Q; Buchholz, P; Buckley, A G; Buda, S I; Budagov, I A; Buehrer, F; Bugge, L; Bugge, M K; Bulekov, O; Bullock, D; Burckhart, H; Burdin, S; Burgard, C D; Burghgrave, B; Burke, S; Burmeister, I; Busato, E; Büscher, D; Büscher, V; Bussey, P; Butler, J M; Butt, A I; Buttar, C M; Butterworth, J M; Butti, P; Buttinger, W; Buzatu, A; Buzykaev, A R; Cabrera Urbán, S; Caforio, D; Cairo, V M; Cakir, O; Calace, N; Calafiura, P; Calandri, A; Calderini, G; Calfayan, P; Caloba, L P; Calvet, D; Calvet, S; Camacho Toro, R; Camarda, S; Camarri, P; Cameron, D; Caminal Armadans, R; Campana, S; Campanelli, M; Campoverde, A; Canale, V; Canepa, A; Cano Bret, M; Cantero, J; Cantrill, R; Cao, T; Capeans Garrido, M D M; Caprini, I; 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A search for the flavour-changing neutral-current decay [Formula: see text] is presented. Data collected by the ATLAS detector during 2012 from proton-proton collisions at the Large Hadron Collider at a centre-of-mass energy of [Formula: see text] TeV, corresponding to an integrated luminosity of 20.3 fb[Formula: see text], are analysed. Top-quark pair-production events with one top quark decaying through the [Formula: see text] ([Formula: see text]) channel and the other through the dominant Standard Model mode [Formula: see text] are considered as signal. Only the decays of the Z boson to charged leptons and leptonic W boson decays are used. No evidence for a signal is found and an observed (expected) upper limit on the [Formula: see text] branching ratio of [Formula: see text] ([Formula: see text]) is set at the 95 % confidence level.

Beyond face value: does involuntary emotional anticipation shape the perception of dynamic facial expressions?

PubMed

Palumbo, Letizia; Jellema, Tjeerd

2013-01-01

Emotional facial expressions are immediate indicators of the affective dispositions of others. Recently it has been shown that early stages of social perception can already be influenced by (implicit) attributions made by the observer about the agent's mental state and intentions. In the current study possible mechanisms underpinning distortions in the perception of dynamic, ecologically-valid, facial expressions were explored. In four experiments we examined to what extent basic perceptual processes such as contrast/context effects, adaptation and representational momentum underpinned the perceptual distortions, and to what extent 'emotional anticipation', i.e. the involuntary anticipation of the other's emotional state of mind on the basis of the immediate perceptual history, might have played a role. Neutral facial expressions displayed at the end of short video-clips, in which an initial facial expression of joy or anger gradually morphed into a neutral expression, were misjudged as being slightly angry or slightly happy, respectively (Experiment 1). This response bias disappeared when the actor's identity changed in the final neutral expression (Experiment 2). Videos depicting neutral-to-joy-to-neutral and neutral-to-anger-to-neutral sequences again produced biases but in opposite direction (Experiment 3). The bias survived insertion of a 400 ms blank (Experiment 4). These results suggested that the perceptual distortions were not caused by any of the low-level perceptual mechanisms (adaptation, representational momentum and contrast effects). We speculate that especially when presented with dynamic, facial expressions, perceptual distortions occur that reflect 'emotional anticipation' (a low-level mindreading mechanism), which overrules low-level visual mechanisms. Underpinning neural mechanisms are discussed in relation to the current debate on action and emotion understanding.

Beyond Face Value: Does Involuntary Emotional Anticipation Shape the Perception of Dynamic Facial Expressions?

PubMed Central

Palumbo, Letizia; Jellema, Tjeerd

2013-01-01

Emotional facial expressions are immediate indicators of the affective dispositions of others. Recently it has been shown that early stages of social perception can already be influenced by (implicit) attributions made by the observer about the agent’s mental state and intentions. In the current study possible mechanisms underpinning distortions in the perception of dynamic, ecologically-valid, facial expressions were explored. In four experiments we examined to what extent basic perceptual processes such as contrast/context effects, adaptation and representational momentum underpinned the perceptual distortions, and to what extent ‘emotional anticipation’, i.e. the involuntary anticipation of the other’s emotional state of mind on the basis of the immediate perceptual history, might have played a role. Neutral facial expressions displayed at the end of short video-clips, in which an initial facial expression of joy or anger gradually morphed into a neutral expression, were misjudged as being slightly angry or slightly happy, respectively (Experiment 1). This response bias disappeared when the actor’s identity changed in the final neutral expression (Experiment 2). Videos depicting neutral-to-joy-to-neutral and neutral-to-anger-to-neutral sequences again produced biases but in opposite direction (Experiment 3). The bias survived insertion of a 400 ms blank (Experiment 4). These results suggested that the perceptual distortions were not caused by any of the low-level perceptual mechanisms (adaptation, representational momentum and contrast effects). We speculate that especially when presented with dynamic, facial expressions, perceptual distortions occur that reflect ‘emotional anticipation’ (a low-level mindreading mechanism), which overrules low-level visual mechanisms. Underpinning neural mechanisms are discussed in relation to the current debate on action and emotion understanding. PMID:23409112

Mutation exposed: a neutral explanation for extreme base composition of an endosymbiont genome.

PubMed

Wernegreen, Jennifer J; Funk, Daniel J

2004-12-01

The influence of neutral mutation pressure versus selection on base composition evolution is a subject of considerable controversy. Yet the present study represents the first explicit population genetic analysis of this issue in prokaryotes, the group in which base composition variation is most dramatic. Here, we explore the impact of mutation and selection on the dynamics of synonymous changes in Buchnera aphidicola, the AT-rich bacterial endosymbiont of aphids. Specifically, we evaluated three forms of evidence. (i) We compared the frequencies of directional base changes (AT-->GC vs. GC-->AT) at synonymous sites within and between Buchnera species, to test for selective preference versus effective neutrality of these mutational categories. Reconstructed mutational changes across a robust intraspecific phylogeny showed a nearly 1:1 AT-->GC:GC-->AT ratio. Likewise, stationarity of base composition among Buchnera species indicated equal rates of AT-->GC and GC-->AT substitutions. The similarity of these patterns within and between species supported the neutral model. (ii) We observed an equivalence of relative per-site AT mutation rate and current AT content at synonymous sites, indicating that base composition is at mutational equilibrium. (iii) We demonstrated statistically greater equality in the frequency of mutational categories in Buchnera than in parallel mammalian studies that documented selection on synonymous sites. Our results indicate that effectively neutral mutational pressure, rather than selection, represents the major force driving base composition evolution in Buchnera. Thus they further corroborate recent evidence for the critical role of reduced N(e) in the molecular evolution of bacterial endosymbionts.

Compensated control loops for a 30-cm ion thruster

NASA Technical Reports Server (NTRS)

Robson, R. R.

1976-01-01

The vaporizer dynamic control characteristics of a 30-cm diameter mercury ion thruster were determined by operating the thruster in an open loop steady state mode and then introducing a small sinusoidal signal on the main, cathode, or neutralizer vaporizer current and observing the response of the beam current, discharge voltage, and neutralizer keeper voltage, respectively. This was done over a range of frequencies and operating conditions. From these data, Bode plots for gain and phase were made and mathematical models were obtained. The Bode plots and mathematical models were analyzed for stability and appropriate compensation networks determined. The compensated control loops were incorporated into a power processor and operated with a thruster. The time responses of the compensated loops to changes in set points and recovery from arc conditions are presented.

Mumps outbreaks in a highly vaccinated population: Investigation of a neutralization titre against the current circulating wildtype genotype G5 mumps virus.

PubMed

Kenny, Lena; O'Kelly, Edwin; Connell, Jeff; De Gascun, Cillian; Hassan, Jaythoon

2016-01-01

Mumps outbreaks continue to occur globally, despite high levels of uptake of the mumps vaccine. In order to address immunity to the current circulating wildtype virus, we sought to determine a mumps G5 specific IgG quantitative value which correlates with genotype G5 specific neutralization ability in vitro. Sera from 199 individuals including controls and acute mumps cases were assessed for mumps specific IgG titres using five different enzyme immunoassays coated with antigen from different mumps virus strains. A subset of 66 sera was also assessed for in vitro neutralizing antibody against a contemporary circulating genotype G5 mumps virus. For all the different antigenic targets, mumps specific IgG titres were higher in patients following acute mumps infection compared to controls. In acute mumps infected patients, females showed significantly higher serum titres of anti-G5 IgG compared to males (p<0.05). Furthermore, control males did not show any change in G5 specific IgG with increasing age whereas females show a progressive rise in titre. Linear regression analysis revealed a significant association between the mumps G5 specific IgG levels in the EIA and the in vitro neutralization titres (r(2)=0.59). Specific IgG to the current circulating genotype G5 mumps strain showed significantly lower titres in males which supports our previous observation that there is a male gender bias in cases of acute mumps infection. Furthermore, in this preliminary study, the data indicate that genotype G5 specific IgG levels of >40 RU/ml are required for neutralization capability to be observed in vitro. Copyright © 2015 Elsevier B.V. All rights reserved.

The neutral current sheet and its radiation pairs of side sources in coronal mass ejections

NASA Astrophysics Data System (ADS)

Ji, Shu-Chen

Using the data observed with the soft X-ray telescope, hard X-ray telescope aboard on Yohkoh and the Nobeyama Radioheliograph on 1998 April 23, a comprehensive study on soft X-ray coronal mass ejection (SXRCME) and radio Type IV burst is carried out and some significant results are obtained as follows: A magnetic capacity belt (MCB) between two magnetic dipole sources (MDSs) was found and there were only a few activitation sources (ASs). During the MCB changed into a magnetic energy belt (MEB) by the ASs, activating energy and shining material both concentrated to the neutral current sheet (NCS) in the course of its formation. When two MDSs were put through by the MEB, the NCS formed and the SXRCME occurred. The matter ejected not only from the NCS, but also from the whole MEB. The expanding loop of the SXRCME had two foot points, both were just two MDSs. The head of the expanding loop always tended to the foot point of the weak source, because it was equilibrium point of magnetic pressures coming from two foot points. For this reason, its locus was neutral line. From this, the neutral line can also determine the position of NCS. Finally, the radiation pairs of side sources of NCS on the MEB are found.

Generation of electric fields and currents by neutral flows in weakly ionized plasmas through collisional dynamos

NASA Astrophysics Data System (ADS)

Dimant, Y. S.; Oppenheim, M. M.; Fletcher, A. C.

2016-08-01

In weakly ionized plasmas neutral flows drag plasma across magnetic field lines generating intense electric fields and currents. An example occurs in the Earth's ionosphere near the geomagnetic equator. Similar processes take place in the Solar chromosphere and magnetohydrodynamic generators. This paper argues that not all convective neutral flows generate electric fields and currents and it introduces the corresponding universal criterion for their formation, ∇×(U ×B )≠∂B /∂t , where U is the neutral flow velocity, B is the magnetic field, and t is time. This criterion does not depend on the conductivity tensor, σ ̂ . For many systems, the displacement current, ∂B /∂t , is negligible making the criterion even simpler. This theory also shows that the neutral-dynamo driver that generates E-fields and currents plays the same role as the DC electric current plays for the generation of the magnetic field in the Biot-Savart law.

Electroweak penguins at LHCb

NASA Astrophysics Data System (ADS)

He, Jibo; LHCb Collaboration

2016-04-01

Electroweak penguin decays are flavour-changing neutral current processes, and are highly suppressed in the Standard Model. They can only proceed via loop diagrams. Such decays may receive contributions from New Physics and change their decay behaviours like decay rate and angular distribution. Studying the properties of these decays thus provides a powerful method to probe for New Physics. In this contribution the most recent LHCb results on electroweak penguin decays are reported.

Triggered lightning spectroscopy: Part 1. A qualitative analysis

NASA Astrophysics Data System (ADS)

Walker, T. Daniel; Christian, Hugh J.

2017-08-01

The first high-speed spectra of triggered lightning have been obtained. During the summers of 2012 and 2013, spectra were recorded at the International Center for Lightning Research and Testing, Camp Blanding, FL. The spectra were recorded with a high-speed camera with a grism mounted in front of it. The triggered lightning channels observed were generally at low altitude in a region that included the copper wire. Spectral emissions were recorded at each phase: the initial stage, dart leader, return stroke, and continuing current. These spectra are separated into two major regions: soft ultraviolet to visible (3800-6200 Å) and visible to near infrared (6200-8700 Å). The emissions during the initial stage reflect those of a copper wire burn in air. The majority of the emissions are neutral copper. After the initial stage comes the first return stroke which contains no detected molecular emissions; however, it does contain neutral, singly, and doubly ionized nitrogen and oxygen, neutral argon, and neutral hydrogen. Occasionally, before a return stroke, the dart leader coming down the channel will be stepped. During these occasions the leader spectra resemble that of the return stroke but are dimmer and shorter lived. After the initial portion of the return stroke, there are often changes in the luminosity of the spectrum which corresponds with fluctuations in the continuing current. During these "reillumination phases" no singly or doubly ionized lines have been observed to reemerge over the detection threshold, only neutral emission features.

Current disruptions in the near-earth neutral sheet region

NASA Technical Reports Server (NTRS)

Lui, A. T. Y.; Lopez, R. E.; Anderson, B. J.; Takahashi, K.; Zanetti, L. J.; Mcentire, R. W.; Potemra, T. A.; Klumpar, D. M.; Greene, E. M.; Strangeway, R.

1992-01-01

Current disruption events observed by the Charge Composition Explorer during 1985 and 1986 are examined. Occurrence of current disruption was accompanied by large magnetic field turbulence and frequently with reversal in the sign of the field component normal to the neutral sheet. Current disruptions in the near-earth region are found to be typically shortlived (about 1-5 min), and their onsets coincide well with the ground onsets of substorm expansion or intensification in the local time sector of the footpoint of the spacecraft. These events are found almost exclusively close to the field reversal plane of the neutral sheet (within about 0.5 RE). Prior to current disruption the field strength can be reduced to as low as one seventh of the dipole field value and can recover to nearly the dipole value after disruption. The temporal evolution of particle pressure in the near-earth neutral sheet during the onset of current disruption indicates that the current buildup during the substorm growth phase is associated with enhancement in the particle pressure at the neutral sheet.

Neutral Pion Production in MINERvA

NASA Astrophysics Data System (ADS)

Palomino, Jose

2012-03-01

MINERνA is a neutrino-nucleus scattering experiment employing multiple nuclear targets. The experiment is searching for neutral pion production, both in charged current and neutral current, from coherent, resonant and deep-inelastic processes off these targets. Neutral pions are detected through the 2 photon decay that then produce electromagnetic showers. We will describe how we isolate and reconstruct the electromagnetic showers to calculate the invariant mass of the photon pair.

The neutral wind 'flywheel' as a source of quiet-time, polar-cap currents

NASA Technical Reports Server (NTRS)

Lyons, L. R.; Walterscheid, R. L.; Killeen, T. L.

1985-01-01

The neutral wind pattern over the summer polar cap can be driven by plasma convection to resemble the convection pattern. For a north-south component of the interplanetary magnetic field Bz directed southward, the wind speeds in the conducting E-region can become approximately 25 percent of the electric field drift speeds. If convection ceases, this neutral wind distribution can drive a significant polar cap current system for approximately 6 hours. The currents are reversed from those driven by the electric fields for southward Bz, and the Hall and field-aligned components of the current system resemble those observed during periods of northward Bz. The current magnitudes are similar to those observed during periods of small, northward Bz; however, observations indicate that electric fields often contribute to the currents as much as, or more than, the neutral winds.

A Passive EMI Filter with Access to the Ungrounded Motor Neutral Line-Its Effect on Eliminating Leakage Current from the Inverter Heat Sink-

NASA Astrophysics Data System (ADS)

Doumoto, Takafumi; Akagi, Hirofumi

This paper deals with a leakage current flowing out of the heat sink of a voltage-source PWM inverter. The heat-sink leakage current is caused by a steep change in the common-mode voltage produced by the inverter. It flows through parasitic capacitors between the heat sink and power semiconductor devices when no EMI filter is connected. Experimental results reveal that the heat-sink leakage current flows not into the supply side, but into the motor side. These understandings succeed in describing an equivalent common-mode circuit taking the parasitic capacitors into account. The authors have proposed a passive EMI filter that is unique in access to the ungrounded motor neutral line. It is discussed from this equivalent circuit that the passive EMI filter is effective in preventing the leakage current from flowing. Moreover, installation of another small-sized common-mode inductor at the ac side of the diode rectifier prevents the leakage current from flowing into the supply side. Experimental results obtained from a 200-V, 3.7-kW laboratory system confirm the effectiveness and viability of the EMI filter.

Calculation of the non-inductive current profile in high-performance NSTX plasmas

NASA Astrophysics Data System (ADS)

Gerhardt, S. P.; Fredrickson, E.; Gates, D.; Kaye, S.; Menard, J.; Bell, M. G.; Bell, R. E.; Le Blanc, B. P.; Kugel, H.; Sabbagh, S. A.; Yuh, H.

2011-03-01

The constituents of the current profile have been computed for a wide range of high-performance plasmas in NSTX (Ono et al 2000 Nucl. Fusion 40 557); these include cases designed to maximize the non-inductive fraction, pulse length, toroidal-β or stored energy. In the absence of low-frequency MHD activity, good agreement is found between the reconstructed current profile and that predicted by summing the independently calculated inductive, pressure-driven and neutral beam currents, without the need to invoke any anomalous beam ion diffusion. Exceptions occur, for instance, when there are toroidal Alfvén eigenmode avalanches or coupled m/n = 1/1 + 2/1 kink-tearing modes. In these cases, the addition of a spatially and temporally dependent fast-ion diffusivity can reduce the core beam current drive, restoring agreement between the reconstructed profile and the summed constituents, as well as bringing better agreement between the simulated and measured neutron emission rate. An upper bound on the fast-ion diffusivity of ~0.5-1 m2 s-1 is found in 'MHD-free' discharges, based on the neutron emission, the time rate of change in the neutron signal when a neutral beam is stepped and reconstructed on-axis current density.

Search for flavour-changing neutral current top-quark decays to qZ in pp collision data collected with the ATLAS detector at √s = 8 TeV

DOE PAGES

Aad, G.; Abbott, B.; Abdallah, J.; ...

2016-01-08

A search for the flavour-changing neutral-current decay t → qZ is presented. Data collected by the ATLAS detector during 2012 from proton–proton collisions at the Large Hadron Collider at a centre-of-mass energy of √s = 8 TeV, corresponding to an integrated luminosity of 20.3 fb –1 , are analysed. Top-quark pair-production events with one top quark decaying through the t → qZ ( q=u,c ) channel and the other through the dominant Standard Model mode t → bW are considered as signal. Only the decays of the Z boson to charged leptons and leptonic W boson decays are used. Furthermore,more » no evidence for a signal is found and an observed (expected) upper limit on the t → qZ branching ratio of 7×10 –4 ( 8×10 –4) is set at the 95 % confidence level« less

Discharge Characterization of 40 cm-Microwave ECR Ion Source and Neutralizer

NASA Technical Reports Server (NTRS)

Foster, John E.; Patterson, Michael J.; Britton, Melissa

2003-01-01

Discharge characteristics of a 40 cm, 2.45 GHz Electron Cyclotron Resonance (ECR) ion thruster discharge chamber and neutralizer were acquired. Thruster bulk discharge plasma characteristics were assessed using a single Langmuir probe. Total extractable ion current was measured as a function of input microwave power and flow rate. Additionally, radial ion current density profiles at the thruster.s exit plane were characterized using five equally spaced Faraday probes. Distinct low and high density operating modes were observed as discharge input power was varied from 0 to 200 W. In the high mode, extractable ion currents as high as 0.82 A were measured. Neutralizer emission current was characterized as a function of flow rate and microwave power. Neutralizer extraction currents as high as 0.6 A were measured.

Effect of Thermospheric Neutral Density upon Inner Trapped-belt Proton Flux

NASA Technical Reports Server (NTRS)

Wilson, Thomas L.; Lodhi, M. A. K.; Diaz, Abel B.

2007-01-01

We wish to point out that a secular change in the Earth's atmospheric neutral density alters charged-particle lifetime in the inner trapped radiation belts, in addition to the changes recently reported as produced by greenhouse gases. Heretofore, changes in neutral density have been of interest primarily because of their effect on the orbital drag of satellites. We extend this to include the orbital lifetime of charged particles in the lower radiation belts. It is known that the charged-belt population is coupled to the neutral density of the atmosphere through changes induced by solar activity, an effect produced by multiple scattering off neutral and ionized atoms along with ionization loss in the thermosphere where charged and neutral populations interact. It will be shown here that trapped-belt flux J is bivariant in energy E and thermospheric neutral density , as J(E,rho). One can conclude that proton lifetimes in these belts are also directly affected by secular changes in the neutral species populating the Earth s thermosphere. This result is a consequence of an intrinsic property of charged-particle flux, that flux is not merely a function of E but is dependent upon density rho when a background of neutrals is present.

Evidence for Neutral-Current Diffractive π 0 Production from Hydrogen in Neutrino Interactions on Hydrocarbon

DOE PAGES

Wolcott, J.; Aliaga, L.; Altinok, O.; ...

2016-09-01

Here, the MINERvA experiment observes an excess of events containing electromagnetic showers relative to the expectation from Monte Carlo simulations in neutral-current neutrino interactions with mean beam energy of 4.5 GeV on a hydrocarbon target. The excess is characterized and found to be consistent with neutral-current π 0 production with a broad energy distribution peaking at 7 GeV and a total cross section of 0.26more » $$\\pm$$ 0.02 (stat) $$\\pm$$ 0.08 (sys) x $$10^{-39} cm^{2}$$. The angular distribution, electromagnetic shower energy, and spatial distribution of the energy depositions of the excess are consistent with expectations from neutrino neutral-current diffractive neutral pion production from hydrogen in the hydrocarbon target. These data comprise the first direct experimental observation and constraint for a reaction that poses an important background process in neutrino oscillation experiments searching for $$\

Modeling the near-Earth interaction between ring current ions and exospheric neutrals: escape through energetic neutral atoms (ENAs)

NASA Astrophysics Data System (ADS)

LLera, K.; Goldstein, J.; McComas, D. J.; Valek, P. W.

2016-12-01

The two major loss processes for ring current decay are precipitation and energetic neutral atoms (ENAs). Since the exospheric neutral density increases with decreasing altitudes, precipitating ring current ions (reaching down to 200 - 800 km in altitude) also produce low-altitude ENA signatures that can be stronger than the ring current emission at equatorial distances ( 2 - 9 Re). The higher density results in multiple collisions between the ring current ions and exospheric oxygen. The affect on hydrogen ions is the focus of this study. Since the H particle sustains energy loss ( 36 eV) at each neutralizing or re-ionizing interaction, the escaped ENAs do not directly reflect the ring current properties. We model the energy loss due to multiple charge exchange and electron stripping interactions of 1 - 100 keV precipitating ring current ions undergo before emerging as low-altitude ENAs. The H particle is either an ion or an ENA throughout the simulation. Their lifetime is analytically determined by the length of one mean free path. We track the ion state with Lorentz motion while the ENA travels ballistically across the geomagnetic field. Our simulations show the energy loss is greater than 20% for hydrogen ring current ions below 30 keV (60 keV for the simulations that wander equatorward). This is the first quantification of the energy loss associated with the creation of low-altitude ENAs. Our model (currently constrained in the meridional plane) has revealed characteristics on how precipitation is affected by the near-Earth neutral exosphere. This ion-neutral interaction removes particles from the loss cone but promotes loss through ENA generation. These findings should be implemented in models predicting the ring current decay and used as an analysis tool to reconstruct the ring current population from observed low-altitude ENAs.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Petty, C. C., E-mail: petty@fusion.gat.com; Van Zeeland, M. A.; Pace, D. C.

“Steady-state” hybrid plasmas in DIII-D with zero surface loop voltage have been maintained for up to two current relaxation times using 3.4 MW of central electron cyclotron current drive (ECCD). In addition to driving ≈0.2 MA of plasma current, central ECCD leads to significant changes in Alfvén eigenmode (AE) activity and thermal transport. For neutral-beam-only heating, strong AE activity is observed that causes a ∼35% degradation in the neutron rate. With central ECCD this AE activity is suppressed, replaced by a bursty energetic particle mode that appears more benign as the neutron rate is closer to the classical value. Themore » electron thermal diffusivity increases by ≈50% for 2.4 MW of ECCD compared to neutral-beam-only cases. Fortunately, the global thermal confinement factor remains the same (H{sub 98y2}=1.4) as the higher thermal transport for P{sub EC}=2.4 MW hybrids is offset by the decreased fast ion transport resulting from AE suppression.« less

Non-neutralized Electric Currents in Solar Active Regions and Flare Productivity

NASA Astrophysics Data System (ADS)

Kontogiannis, Ioannis; Georgoulis, Manolis K.; Park, Sung-Hong; Guerra, Jordan A.

2017-11-01

We explore the association of non-neutralized currents with solar flare occurrence in a sizable sample of observations, aiming to show the potential of such currents in solar flare prediction. We used the high-quality vector magnetograms that are regularly produced by the Helioseismic Magnetic Imager, and more specifically, the Space weather HMI Active Region Patches (SHARP). Through a newly established method that incorporates detailed error analysis, we calculated the non-neutralized currents contained in active regions (AR). Two predictors were produced, namely the total and the maximum unsigned non-neutralized current. Both were tested in AR time-series and a representative sample of point-in-time observations during the interval 2012 - 2016. The average values of non-neutralized currents in flaring active regions are higher by more than an order of magnitude than in non-flaring regions and correlate very well with the corresponding flare index. The temporal evolution of these parameters appears to be connected to physical processes, such as flux emergence and/or magnetic polarity inversion line formation, that are associated with increased solar flare activity. Using Bayesian inference of flaring probabilities, we show that the total unsigned non-neutralized current significantly outperforms the total unsigned magnetic flux and other well-established current-related predictors. It therefore shows good prospects for inclusion in an operational flare-forecasting service. We plan to use the new predictor in the framework of the FLARECAST project along with other highly performing predictors.

Status of the Negative Ion Based Heating and Diagnostic Neutral Beams for ITER

NASA Astrophysics Data System (ADS)

Schunke, B.; Bora, D.; Hemsworth, R.; Tanga, A.

2009-03-01

The current baseline of ITER foresees 2 Heating Neutral Beam (HNB's) systems based on negative ion technology, each accelerating to 1 MeV 40 A of D- and capable of delivering 16.5 MW of D0 to the ITER plasma, with a 3rd HNB injector foreseen as an upgrade option [1]. In addition a dedicated Diagnostic Neutral Beam (DNB) accelerating 60 A of H- to 100 keV will inject ≈15 A equivalent of H0 for charge exchange recombination spectroscopy and other diagnostics. Recently the RF driven negative ion source developed by IPP Garching has replaced the filamented ion source as the reference ITER design. The RF source developed at IPP, which is approximately a quarter scale of the source needed for ITER, is expected to have reduced caesium consumption compared to the filamented arc driven ion source. The RF driven source has demonstrated adequate accelerated D- and H- current densities as well as long-pulse operation [2, 3]. It is foreseen that the HNB's and the DNB will use the same negative ion source. Experiments with a half ITER-size ion source are on-going at IPP and the operation of a full-scale ion source will be demonstrated, at full power and pulse length, in the dedicated Ion Source Test Bed (ISTF), which will be part of the Neutral Beam Test Facility (NBTF), in Padua, Italy. This facility will carry out the necessary R&D for the HNB's for ITER and demonstrate operation of the full-scale HNB beamline. An overview of the current status of the neutral beam (NB) systems and the chosen configuration will be given and the ongoing integration effort into the ITER plant will be highlighted. It will be demonstrated how installation and maintenance logistics have influenced the design, notably the top access scheme facilitating access for maintenance and installation. The impact of the ITER Design Review and recent design change requests (DCRs) will be briefly discussed, including start-up and commissioning issues. The low current hydrogen phase now envisaged for start-up imposed specific requirements for operating the HNB's at full beam power. It has been decided to address the shinethrough issue by installing wall armour protection, which increases the operational space in all scenarios. Other NB related issues identified by the Design Review process will be discussed and the possible changes to the ITER baseline indicated.

Status of the Negative Ion Based Heating and Diagnostic Neutral Beams for ITER

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schunke, B.; Bora, D.; Hemsworth, R.

2009-03-12

The current baseline of ITER foresees 2 Heating Neutral Beam (HNB's) systems based on negative ion technology, each accelerating to 1 MeV 40 A of D{sup -} and capable of delivering 16.5 MW of D{sup 0} to the ITER plasma, with a 3rd HNB injector foreseen as an upgrade option. In addition a dedicated Diagnostic Neutral Beam (DNB) accelerating 60 A of H{sup -} to 100 keV will inject {approx_equal}15 A equivalent of H{sup 0} for charge exchange recombination spectroscopy and other diagnostics. Recently the RF driven negative ion source developed by IPP Garching has replaced the filamented ion sourcemore » as the reference ITER design. The RF source developed at IPP, which is approximately a quarter scale of the source needed for ITER, is expected to have reduced caesium consumption compared to the filamented arc driven ion source. The RF driven source has demonstrated adequate accelerated D{sup -} and H{sup -} current densities as well as long-pulse operation. It is foreseen that the HNB's and the DNB will use the same negative ion source. Experiments with a half ITER-size ion source are on-going at IPP and the operation of a full-scale ion source will be demonstrated, at full power and pulse length, in the dedicated Ion Source Test Bed (ISTF), which will be part of the Neutral Beam Test Facility (NBTF), in Padua, Italy. This facility will carry out the necessary R and D for the HNB's for ITER and demonstrate operation of the full-scale HNB beamline. An overview of the current status of the neutral beam (NB) systems and the chosen configuration will be given and the ongoing integration effort into the ITER plant will be highlighted. It will be demonstrated how installation and maintenance logistics have influenced the design, notably the top access scheme facilitating access for maintenance and installation. The impact of the ITER Design Review and recent design change requests (DCRs) will be briefly discussed, including start-up and commissioning issues. The low current hydrogen phase now envisaged for start-up imposed specific requirements for operating the HNB's at full beam power. It has been decided to address the shinethrough issue by installing wall armour protection, which increases the operational space in all scenarios. Other NB related issues identified by the Design Review process will be discussed and the possible changes to the ITER baseline indicated.« less

Cometary atmospheres: Modeling the spatial distribution of observed neutral radicals

NASA Technical Reports Server (NTRS)

Combi, M. R.

1985-01-01

Progress on modeling the spatial distributions of cometary radicals is described. The Monte Carlo particle-trajectory model was generalized to include the full time dependencies of initial comet expansion velocities, nucleus vaporization rates, photochemical lifetimes and photon emission rates which enter the problem through the comet's changing heliocentric distance and velocity. The effect of multiple collisions in the transition zone from collisional coupling to true free flow were also included. Currently available observations of the spatial distributions of the neutral radicals, as well as the latest available photochemical data were re-evaluated. Preliminary exploratory model results testing the effects of various processes on observable spatial distributions are also discussed.

Measurement of the Q2 dependence of the charged and neutral current cross sections in e±p scattering at HERA

NASA Astrophysics Data System (ADS)

Aid, S.; Andreev, V.; Andrieu, B.; Appuhn, R.-D.; Arpagaus, M.; Babaev, A.; Bähr, J.; Bán, J.; Ban, Y.; Baranov, P.; Barrelet, E.; Barschke, R.; Bartel, W.; Barth, M.; Bassler, U.; Beck, H. P.; Behrend, H.-J.; Belousov, A.; Berger, Ch.; Bernardi, G.; Bernet, R.; Bertrand-Coremans, G.; Besançon, M.; Beyer, R.; Biddulph, P.; Bispham, P.; Bizot, J. C.; Blobel, V.; Borras, K.; Botterweck, F.; Boudry, V.; Braemer, A.; Braunschweig, W.; Brisson, V.; Bruncko, D.; Brune, C.; Buchholz, R.; Büngener, L.; Bürger, J.; Büsser, F. W.; Buniatian, A.; Burke, S.; Burton, M. J.; Buschhorn, G.; Campbell, A. J.; Carli, T.; Charlet, M.; Clarke, D.; Clegg, A. B.; Clerbaux, B.; Cocks, S.; Contreras, J. G.; Cormack, C.; Coughlan, J. A.; Courau, A.; Cousinou, M.-C.; Cozzika, G.; Criegee, L.; Cussans, D. G.; Cvach, J.; Dagoret, S.; Dainton, J. B.; Dau, W. D.; Daum, K.; David, M.; Davis, C. L.; Delcourt, B.; De Roeck, A.; De Wolf, E. A.; Dirkmann, M.; Dixon, P.; Di Nezza, P.; Dlugosz, W.; Dollfus, C.; Dowell, J. D.; Dreis, H. B.; Droutskoi, A.; Düllmann, D.; Dünger, O.; Duhm, H.; Ebert, J.; Ebert, T. R.; Eckerlin, G.; Efremenko, V.; Egli, S.; Eichler, R.; Eisele, F.; Eisenhandler, E.; Ellison, R. J.; Elsen, E.; Erdmann, M.; Erdmann, W.; Evrard, E.; Fahr, A. B.; Favart, L.; Fedotov, A.; Feeken, D.; Felst, R.; Feltesse, J.; Ferencei, J.; Ferrarotto, F.; Flamm, K.; Fleischer, M.; Flieser, M.; Flügge, G.; Fomenko, A.; Fominykh, B.; Formánek, J.; Foster, J. M.; Franke, G.; Fretwurst, E.; Gabathuler, E.; Gabathuler, K.; Gaede, F.; Garvey, J.; Gayler, J.; Gebauer, M.; Gellrich, A.; Genzel, H.; Gerhards, R.; Glazov, A.; Goerlach, U.; Goerlich, L.; Gogitidze, N.; Goldberg, M.; Goldner, D.; Golec-Biernat, K.; Gonzalez-Pineiro, B.; Gorelov, I.; Grab, C.; Grässler, H.; Grässler, R.; Greenshaw, T.; Griffiths, R.; Grindhammer, G.; Gruber, A.; Gruber, C.; Haack, J.; Haidt, D.; Hajduk, L.; Hampel, M.; Hapke, M.; Haynes, W. J.; Heinzelmann, G.; Henderson, R. C. W.; Henschel, H.; Herynek, I.; Hess, M. F.; Hildesheim, W.; Hiller, K. H.; Hilton, C. D.; Hladký, J.; Hoeger, K. C.; Höppner, M.; Hoffmann, D.; Holtom, T.; Horisberger, R.; Hudgson, V. L.; Hütte, M.; Hufnagel, H.; Ibbotson, M.; Itterbeck, H.; Jacholkowska, A.; Jacobsson, C.; Jaffre, M.; Janoth, J.; Jansen, T.; Jönsson, L.; Johannsen, K.; Johnson, D. P.; Johnson, L.; Jung, H.; Kalmus, P. I. P.; Kander, M.; Kant, D.; Kaschowitz, R.; Kathage, U.; Katzy, J.; Kaufmann, H. H.; Kaufmann, O.; Kazarian, S.; Kenyon, I. R.; Kermiche, S.; Keuker, C.; Kiesling, C.; Klein, M.; Kleinwort, C.; Knies, G.; Köhler, T.; Köhne, J. H.; Kolanoski, H.; Kole, F.; Kolya, S. D.; Korbel, V.; Korn, M.; Kostka, P.; Kotelnikov, S. K.; Krämerkämper, T.; Krasny, M. W.; Krehbiel, H.; Krücker, D.; Krüger, U.; Krüner-Marquis, U.; Küster, H.; Kuhlen, M.; Kurča, T.; Kurzhöfer, J.; Lacour, D.; Laforge, B.; Lander, R.; Landon, M. P. J.; Lange, W.; Langenegger, U.; Laporte, J.-F.; Lebedev, A.; Lehner, F.; Leverenz, C.; Levonian, S.; Ley, Ch.; Lindström, G.; Lindstroem, M.; Link, J.; Linsel, F.; Lipinski, J.; List, B.; Lobo, G.; Lohmander, H.; Lomas, J. W.; Lopez, G. C.; Lubimov, V.; Lüke, D.; Magnussen, N.; Malinovski, E.; Mani, S.; Maraček, R.; Marage, P.; Marks, J.; Marshall, R.; Martens, J.; Martin, G.; Martin, R.; Martyn, H.-U.; Martyniak, J.; Mavroidis, T.; Maxfield, S. J.; McMahon, S. J.; Mehta, A.; Meier, K.; Merz, T.; Meyer, A.; Meyer, A.; Meyer, H.; Meyer, J.; Meyer, P.-O.; Migliori, A.; Mikocki, S.; Milstead, D.; Moeck, J.; Moreau, F.; Morris, J. V.; Mroczko, E.; Müller, D.; Müller, G.; Müller, K.; Murín, P.; Nagovizin, V.; Nahnhauer, R.; Naroska, B.; Naumann, Th.; Newman, P. R.; Newton, D.; Neyret, D.; Nguyen, H. K.; Nicholls, T. C.; Niebergall, F.; Niebuhr, C.; Niedzballa, Ch.; Niggli, H.; Nisius, R.; Nowak, G.; Noves, G. W.; Nyberg-Werther, M.; Oakden, M.; Oberlack, H.; Obrock, U.; Olsson, J. E.; Ozerov, D.; Palmen, P.; Panaro, E.; Panitch, A.; Pascaud, C.; Patel, G. D.; Pawletta, H.; Peppel, E.; Perez, E.; Phillips, J. P.; Pieuchot, A.; Pitzl, D.; Pope, G.; Prell, S.; Prosi, R.; Rabbertz, K.; Rädel, G.; Raupach, F.; Reimer, P.; Reinshagen, S.; Rick, H.; Riech, V.; Riedlberger, J.; Riepenhausen, F.; Riess, S.; Rizvi, E.; Robertson, S. M.; Robmann, P.; Roloff, H. E.; Roosen, R.; Rosenbauer, K.; Rostovtsev, A.; Rouse, F.; Royon, C.; Rüter, K.; Rusakov, S.; Rybicki, K.; Sahlmann, N.; Sankey, D. P. C.; Schacht, P.; Schiek, S.; Schleif, S.; Schleper, P.; von Schlippe, W.; Schmidt, D.; Schmidt, G.; Schöning, A.; Schröder, V.; Schuhmann, E.; Schwab, B.; Sefkow, F.; Seidel, M.; Sell, R.; Semenov, A.; Shekelyan, V.; Sheviakov, I.; Shtarkov, L. N.; Siegmon, G.; Siewert, U.; Sirois, Y.; Skillicorn, I. O.; Smirnov, P.; Smith, J. R.; Solochenko, V.; Soloviev, Y.; Specka, A.; Spiekermann, J.; Spielman, S.; Spitzer, H.; Squinabol, F.; Starosta, R.; Steenbock, M.; Steffen, P.; Steinberg, R.; Steiner, H.; Stella, B.; Stellberger, A.; Stier, J.; Stiewe, J.; Stößlein, U.; Stolze, K.; Straumann, U.; Struczinski, W.; Sutton, J. P.; Tapprogge, S.; Taševský, M.; Tchernyshov, V.; Tchetchelnitski, S.; Theissen, J.; Thiebaux, C.; Thompson, G.; Truöl, P.; Turnau, J.; Tutas, J.; Uelkes, P.; Usik, A.; Valkár, S.; Valkárová, A.; Vallée, C.; Vandenplas, D.; Van Esch, P.; Van Mechelen, P.; Vazdik, Y.; Verrecchia, P.; Villet, G.; Wacker, K.; Wagener, A.; Wagener, M.; Walther, A.; Waugh, B.; Weber, G.; Weber, M.; Wegener, D.; Wegner, A.; Wengler, T.; Werner, M.; West, L. R.; Wilksen, T.; Willard, S.; Winde, M.; Winter, G.-G.; Wittek, C.; Wünsch, E.; Žáček, J.; Zarbock, D.; Zhang, Z.; Zhokin, A.; Zomer, F.; Zsembery, J.; Zuber, K.; ZurNedden, M.; H1 Collaboration

1996-02-01

The Q2 dependence and the total cross sections for charged and neutral current processes are measured in e±p reactions for transverse momenta of the outgoing lepton larger than 25 GeV. Comparable size of cross sections for the neutral current process and for the weak charged current process are observed above Q2 ∥ 5000 GeV 2. Using the shape and magnitude of the charged current cross section we determine a propagator mass of mW = 84 -7+10 GeV.

Modeling of Elastic Collisions between High Energy and Slow Neutral Atoms

DTIC Science & Technology

2015-07-01

cylindrical test cell, and the currents on the four different electrodes-Inner Cylinder , Exit Plate, Back Aperture, and Collector Plat~were measured...Inner Cylinder electrode. Nevertheless, the neutral atom current to the Inner Cylinder electrode predicted by the VHS model is comparable to the...Figure 9. Normalized curre nt at the Inner Cylinder e lectrode. the point of collision. T he discrepancy in the Exit Plate neutral atom current is due to

Sensitivity Testing of the NSTAR Ion Thruster

NASA Technical Reports Server (NTRS)

Sengupta, Anita; Anderson, John; Brophy, John

2007-01-01

During the Extended Life Test of the DS1 flight spare ion thruster, the engine was subjected to sensitvity testing in order to characterize the macroscopic dependence of discharge chamber sensitivity to a +\\-3% vatiation in main flow, cathode flow and beam current, and to +\\5% variation in beam and accelerator voltage, was determined for the minimum- (THO), half- (TH8) and full power (TH15) throttle levels. For each power level investigared, 16 high/low operating conditions were chosen to vary the flows, beam current, and grid voltages in in a matrix that mapped out the entire parameter space. The matrix of data generated was used to determine the partial derivative or senitivity of the dependent parameters--discharge voltage, discharge current, discharge loss, double-to-single-ion current ratio, and neutralizer-keeper voltage--to the variation in the independent parameters--main flow, cathode flow, beam current, and beam voltage. The sensititivities of each dependent parameter with respect to each independent parameter were determined using a least-square fit routine. Variation in these sensitivities with thruster runtime was recorded over the duration of the ELT, to detemine if discharge performance changed with thruster wear. Several key findings have been ascertained from the sensitivity testing. Discharge operation is most sensitve to changes in cathode flow and to a lesser degree main flow. The data also confirms that for the NSTAR configuration plasma production is limited by primary electron input due to the fixed neutral population. Key sensitivities along with their change with thruster wear (operating time) will be presented. In addition double ion content measurements with an ExB probe will also be presented to illustrate beam ion production and content sensitivity to the discharge chamber operating parameteres.

Feedback between neutral winds and auroral arc electrodynamics

NASA Technical Reports Server (NTRS)

Lyons, L. R.; Walterscheid, R. L.

1986-01-01

The feedback between neutral atmospheric winds and the electrodynamics of a stable, discrete auroral arc is analyzed. The ionospheric current continuity equation and the equation for neutral gas acceleration by ion drag are solved simultaneously, as a function of time. The results show that, in general, the electric field in the ionosphere adjusts to neutral wind acceleration so as to keep auroral field-aligned currents and electron acceleration approximately independent of time. It is thus concluded that the neutral winds that develop as a result of the electrodynamical forcing associated with an arc do not significantly affect the intensity of the arc.

The 'cube' meta-model for the information system of large health sector organizations--a (platform neutral) mapping tool to integrate information system development with changing business functions and organizational development.

PubMed

Balkányi, László

2002-01-01

To develop information systems (IS) in the changing environment of the health sector, a simple but throughout model, avoiding the techno-jargon of informatics, might be useful for the top management. A platform neutral, extensible, transparent conceptual model should be established. Limitations of current methods lead to a simple, but comprehensive mapping, in the form of a three-dimensional cube. The three 'orthogonal' views are (a) organization functionality, (b) organizational structures and (c) information technology. Each of the cube-sides is described according to its nature. This approach enables to define any kind of an IS component as a certain point/layer/domain of the cube and enables also the management to label all IS components independently form any supplier(s) and/or any specific platform. The model handles changes in organization structure, business functionality and the serving info-system independently form each other. Practical application extends to (a) planning complex, new ISs, (b) guiding development of multi-vendor, multi-site ISs, (c) supporting large-scale public procurement procedures and the contracting, implementation phase by establishing a platform neutral reference, (d) keeping an exhaustive inventory of an existing large-scale system, that handles non-tangible aspects of the IS.

Transport in a field aligned magnetized plasma/neutral gas boundary: the end of the plasma

NASA Astrophysics Data System (ADS)

Cooper, Christopher Michael

The objective of this dissertation is to characterize the physics of a boundary layer between a magnetized plasma and a neutral gas along the direction of a confining magnetic field. A series of experiments are performed at the Enormous Toroidal Plasma Device (ETPD) at UCLA to study this field aligned Neutral Boundary Layer (NBL) at the end of the plasma. A Lanthanum Hexaboride (LaB6) cathode and semi-transparent anode creates a magnetized, current-free helium plasma which terminates on a neutral helium gas without touching any walls. Probes are inserted into the plasma to measure the basic plasma parameters and study the transport in the NBL. The experiment is performed in the weakly ionized limit where the plasma density (ne) is much less than the neutral density (nn) such that ne/nn < 5%. The NBL is characterized by a field-aligned electric field which begins at the point where the plasma pressure equilibrates with the neutral gas pressure. Beyond the pressure equilibration point the electrons and ions lose their momentum by collisions with the neutral gas and come to rest. An electric field is established self consistently to maintain a current-free termination through equilibration of the different species' stopping rates in the neutral gas. The electric field resembles a collisional quasineutral sheath with a length 10 times the electron-ion collision length, 100 times the neutral collision length, and 10,000 times the Debye length. Collisions with the neutral gas dominate the losses in the system. The measured plasma density loss rates are above the classical cross-field current-free ambipolar rate, but below the anomalous Bohm diffusion rate. The electron temperature is below the ionization threshold of the gas, 2.2 eV in helium. The ions are in thermal equilibrium with the neutral gas. A generalized theory of plasma termination in a Neutral Boundary Layer is applied to this case using a two-fluid, current-free, weakly ionized transport model. The electron and ion momentum equations along the field are combined in a generalized Ohm's law which predicts the axial electric field required to maintain a current-free termination. The pressure balance criteria for termination and the predicted electric field are confirmed over a scaling of plasma parameters. The experiment and the model are relevant for studying NBLs in other systems, such as the atmospheric termination of the aurora or detached gaseous divertors. A steady state modified ambipolar system is measured in the ETPD NBL. The drift speeds associated with these currents are a small fraction of the plasma flow speeds and the problem is treated as a perturbation to the termination model. The current-free condition on the model is relaxed to explain the presence of the divergence free current.

Single neutral pion production by charged-current $$\\bar{\

DOE PAGES

Le, T.; Paomino, J. L.; Aliaga, L.; ...

2015-10-07

We studied single neutral pion production via muon antineutrino charged-current interactions in plastic scintillator (CH) using the MINERvA detector exposed to the NuMI low-energy, wideband antineutrino beam at Fermilab. Measurement of this process constrains models of neutral pion production in nuclei, which is important because the neutral-current analog is a background for appearance oscillation experiments. Furthermore, the differential cross sections for π 0 momentum and production angle, for events with a single observed π 0 and no charged pions, are presented and compared to model predictions. These results comprise the first measurement of the π 0 kinematics for this process.

Single neutral pion production by charged-current $$\\bar{\

DOE Office of Scientific and Technical Information (OSTI.GOV)

Le, T.; Paomino, J. L.; Aliaga, L.

We studied single neutral pion production via muon antineutrino charged-current interactions in plastic scintillator (CH) using the MINERvA detector exposed to the NuMI low-energy, wideband antineutrino beam at Fermilab. Measurement of this process constrains models of neutral pion production in nuclei, which is important because the neutral-current analog is a background for appearance oscillation experiments. Furthermore, the differential cross sections for π 0 momentum and production angle, for events with a single observed π 0 and no charged pions, are presented and compared to model predictions. These results comprise the first measurement of the π 0 kinematics for this process.

Structural changes of polyacids initiated by their neutralization with various alkali metal hydroxides. Diffusion studies in poly(acrylic acid)s.

PubMed

Masiak, Michal; Hyk, Wojciech; Stojek, Zbigniew; Ciszkowska, Malgorzata

2007-09-27

The changes in the three-dimensional structure of the poly(acrylic acid), PAA, induced by incorporation of various alkali-metal counterions have been evaluated by studying diffusion of an uncharged probe (1,1'-ferrocenedimethanol) in the polymeric media. The studies are supported by the measurements of conductivity and viscosity of the polymeric media. Solutions of linear PAA of four different sizes (molecular weights: 450,000, 750,000, 1,250,000, 4,000,000) were neutralized with hydroxides of alkali metals of group 1 of the periodic table (Li, Na, K, Rb, Cs) to the desired neutralization degree. The transport properties of the obtained polyacrylates were monitored by measuring the changes in the probe diffusion coefficient during the titration of the polyacids. The probe diffusivity was determined from the steady-state current of the probe voltammetric oxidation at disk microelectrodes. Diffusivity of the probe increases with the increase in the degree of neutralization and with the increase in viscosity. It reaches the maximum value at about 60-80% of the polyacid neutralization. The way the probe diffusion coefficients change is similar in all polyacid solutions and gels. The increase in the size of a metal cation causes, in general, an enhancement in the transport of probe molecules. The biggest differences in the probe diffusivities are between lithium and cesium polyacrylates. The differences between the results obtained for cesium and rubidium are not statistically significant due to lack of good precision of the voltammetric measurements. The measurements of the electric conductivity of polyacrylates and the theoretical predictions supplemented the picture of electrostatic interactions between the polyanionic chains and the metal cations of increasing size. In all instances of the PAAs, the viscosity of the solutions rapidly increases in the 0-60% range of neutralization and then becomes constant in the 60-100% region. With the exception of the shortest chain polyacid, the formation of a rigid medium (gel) has been observed in the experiments with all cations. After the end point of the titration was passed, a sudden drop in the viscosity and the disappearance of the gelatinous structure were seen. The largest value of viscosity has been recorded for the longest chain polyacid. The change in the cation of the strong base used did not affect the viscosity of the polymeric system.

Lactation performance by dairy cows fed wet brewers grains or whole cottonseed to replace forage.

PubMed

Firkins, J L; Harvatine, D I; Sylvester, J T; Eastridge, M L

2002-10-01

Holstein cows starting at wk 8 of lactation were used to evaluate lactation performance when wet brewers grains, whole linted cottonseed, or starch-coated whole linted cottonseed (Easiflo) were substituted for forage. The wet brewers grains were added to diets to decrease forage neutral detergent fiber from 21% incrementally down to 15% while simultaneously decreasing nonfiber carbohydrate concentration from 40.3% down to about 33.8%. The cottonseed treatments all had similar concentrations of forage neutral detergent fiber (15%) and nonfiber carbohydrates (33.1 and 36.0%). Dry matter intake and milk production were similar across treatments. Milk fat percentage was decreased for Easiflo versus whole linted cottonseeds, but no other responses were detected. The current National Research Council (NRC) energy model was evaluated using individual cow data that were averaged over the entire 16-wk treatment period. For treatment means, the output of energy averaged 99% of the net energy of lactation intake, indicating very good corroboration of the model to account for energy usage for a group of cows. However, the ability to predict energy usage for individual cows was less accurate based on the comparison of residuals of observed and predicted body weight change regressed against predicted body weight change, apparently because of compounding of random errors in this prediction, which was alleviated over a larger number of observations. These results also corroborate current NRC guidelines for minimum forage neutral detergent fiber concentrations for lactating cows past the calving transition period.

Hebrew Verbal Passives in Later Language Development: The Interface of Register and Verb Morphology

ERIC Educational Resources Information Center

Ravid, Dorit; Vered, Lizzy

2017-01-01

The current study examined the production of Hebrew verbal passives across adolescence as mediated by linguistic register and verb morphology. Participants aged eight to sixteen years and a group of adults were asked to change written active-voice sentences into corresponding passive-voice forms, divided by verb register (neutral and high),…

Search for associated production of a Z boson with a single top quark and for tZ flavour-changing interactions in pp collisions at $$ \\sqrt{s}=8 $$ TeV

DOE PAGES

Sirunyan, A. M.; Tumasyan, A.; Adam, W.; ...

2017-07-03

Here, a search for the production of a single top quark in association with a Z boson is presented, both to identify the expected standard model process and to search for flavour-changing neutral current interactions. The data sample corresponds to an integrated luminosity of 19.7 fb –1 recorded by the CMS experiment at the LHC in proton-proton collisions at √s = 8 TeV. Final states with three leptons (electrons or muons) and at least one jet are investigated. An events yield compatible with tZq standard model production is observed, and the corresponding cross section is measured to be σ(pp →more » tZq → ℓνbℓ +ℓ –q) = 10 –7 +8 fb with a significance of 2.4 standard deviations. No presence of flavour-changing neutral current production of tZq is observed. Exclusion limits at 95% confidence level on the branching fractions of a top quark decaying to a Z boson and an up or a charm quark are found to be Β(t → Zu) < 0.022% and Β(t → Zc) < 0.049%.« less

Search for associated production of a Z boson with a single top quark and for tZ flavour-changing interactions in pp collisions at $$ \\sqrt{s}=8 $$ TeV

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sirunyan, A. M.; Tumasyan, A.; Adam, W.

Here, a search for the production of a single top quark in association with a Z boson is presented, both to identify the expected standard model process and to search for flavour-changing neutral current interactions. The data sample corresponds to an integrated luminosity of 19.7 fb –1 recorded by the CMS experiment at the LHC in proton-proton collisions at √s = 8 TeV. Final states with three leptons (electrons or muons) and at least one jet are investigated. An events yield compatible with tZq standard model production is observed, and the corresponding cross section is measured to be σ(pp →more » tZq → ℓνbℓ +ℓ –q) = 10 –7 +8 fb with a significance of 2.4 standard deviations. No presence of flavour-changing neutral current production of tZq is observed. Exclusion limits at 95% confidence level on the branching fractions of a top quark decaying to a Z boson and an up or a charm quark are found to be Β(t → Zu) < 0.022% and Β(t → Zc) < 0.049%.« less

Search for top quark decays via Higgs-boson-mediated flavor-changing neutral currents in pp collisions at √s = 8 TeV

DOE Office of Scientific and Technical Information (OSTI.GOV)

Khachatryan, V.; Sirunyan, A. M.; Tumasyan, A.

Here, a search is performed for Higgs-boson-mediated flavor-changing neutral currents in the decays of top quarks. The search is based on proton-proton collision data corresponding to an integrated luminosity of 19.7 fb –1 at a center-of-mass energy of 8 TeV collected with the CMS detector at the LHC. Events in which a top quark pair is produced with one top quark decaying into a charm or up quark and a Higgs boson (H), and the other top quark decaying into a bottom quark and a W boson are selected. The Higgs boson in these events is assumed to subsequently decay into either dibosons or difermions. No significant excess is observed above the expected standard model background, and an upper limit at the 95% confidence level is set on the branching fraction B(t → Hc) of 0.40% and B(t → Hu) of 0.55%, where the expected upper limits are 0.43% and 0.40\\%, respectively. These results correspond to upper limits on the square of the flavor-changing Higgs boson Yukawa couplingsmore » $$|\\lambda^{H}_{tu}|^2$$ < 6.9E-3 and $$|\\lambda^{H}_{tu}|^2$$ < 9.8 x 10$$^{-3}$$.« less

Search for top quark decays via Higgs-boson-mediated flavor-changing neutral currents in pp collisions at √s = 8 TeV

DOE PAGES

Khachatryan, V.; Sirunyan, A. M.; Tumasyan, A.; ...

2017-02-15

Here, a search is performed for Higgs-boson-mediated flavor-changing neutral currents in the decays of top quarks. The search is based on proton-proton collision data corresponding to an integrated luminosity of 19.7 fb –1 at a center-of-mass energy of 8 TeV collected with the CMS detector at the LHC. Events in which a top quark pair is produced with one top quark decaying into a charm or up quark and a Higgs boson (H), and the other top quark decaying into a bottom quark and a W boson are selected. The Higgs boson in these events is assumed to subsequently decay into either dibosons or difermions. No significant excess is observed above the expected standard model background, and an upper limit at the 95% confidence level is set on the branching fraction B(t → Hc) of 0.40% and B(t → Hu) of 0.55%, where the expected upper limits are 0.43% and 0.40\\%, respectively. These results correspond to upper limits on the square of the flavor-changing Higgs boson Yukawa couplingsmore » $$|\\lambda^{H}_{tu}|^2$$ < 6.9E-3 and $$|\\lambda^{H}_{tu}|^2$$ < 9.8 x 10$$^{-3}$$.« less

Termination of a Magnetized Plasma on a Neutral Gas: The End of the Plasma

NASA Astrophysics Data System (ADS)

Cooper, C. M.; Gekelman, W.

2013-06-01

Experiments are performed at the Enormous Toroidal Plasma Device at UCLA to study the neutral boundary layer (NBL) between a magnetized plasma and a neutral gas along the direction of a confining magnetic field. This is the first experiment to measure plasma termination within a neutral gas without the presence of a wall or obstacle. A magnetized, current-free helium plasma created by a lanthanum hexaboride (LaB6) cathode terminates entirely within a neutral helium gas. The plasma is weakly ionized (ne/nn˜1%) and collisional λn≪Lplasma. The NBL occurs where the plasma pressure equilibrates with the neutral gas pressure, consistent with a pressure balance model. It is characterized by a field-aligned ambipolar electric field, developing self-consistently to maintain a current-free termination of the plasma on the neutral gas. Probes are inserted into the plasma to measure the plasma density, flow, temperature, current, and potential. These measurements confirm the presence of the ambipolar field and the pressure equilibration model of the NBL.

The Effects of Neutral Inertia on Ionospheric Currents in the High-Latitude Thermosphere Following a Geomagnetic Storm

NASA Technical Reports Server (NTRS)

Deng, W.; Killeen, T. L.; Burns, A. G.; Roble, R. G.; Slavin, J. A.; Wharton, L. E.

1993-01-01

Results of an experimental and theoretical investigation into the effects of the time dependent neutral wind flywheel on high-latitude ionospheric electrodynamics are presented. The results extend our previous work which used the National Center for Atmospheric Research Thermosphere/Ionosphere General Circulation Model (NCAR TIGCM) to theoretically simulate flywheel effects in the aftermath of a geomagnetic storm. The previous results indicated that the neutral circulation, set up by ion-neutral momentum coupling in the main phase of a geomagnetic storm, is maintained for several hours after the main phase has ended and may dominate height-integrated Hall currents and field-aligned currents for up to 4-5 hours. We extend the work of Deng et al. to include comparisons between the calculated time-dependent ionospheric Hall current system in the storm-time recovery period and that measured by instruments on board the Dynamics Explorer 2 (DE 2) satellite. Also, comparisons are made between calculated field-aligned currents and those derived from DE 2 magnetometer measurements. These calculations also allow us to calculate the power transfer rate (sometimes called the Poynting flux) between the magnetosphere and ionosphere. The following conclusions have been drawn: (1) Neutral winds can contribute significantly to the horizontal ionospheric current system in the period immediately following the main phase of a geomagnetic storm, especially over the magnetic polar cap and in regions of ion drift shear. (2) Neutral winds drive Hall currents that flow in the opposite direction to those driven by ion drifts. (3) The overall morphology of the calculated field-aligned current system agrees with previously published observations for the interplanetary magnetic field (IMF) B(sub Z) southward conditions, although the region I and region 2 currents are smeared by the TI(ICM model grid resolution. (4) Neutral winds can make significant contributions to the field-aligned current system when B(sub Z) northward conditions prevail following the main phase of a storm, but can account for only a fraction of the observed currents. (5) DE 2 measurements provide a demonstration of "local" (satellite-altitude) flywheel effects. (6) On the assumption that the magnetosphere acts as an insulator, we calculate neutral-wind-induced polarization electric fields of approx. 20-30 kV in the period immediately following the geomagnetic storm.

An economic evaluation of alternative biofuel deployment scenarios in the USA

DOE Office of Scientific and Technical Information (OSTI.GOV)

Oladosu, Gbadebo

Energy market conditions have shifted dramatically since the USA renewable fuel standards (RFS1 in 2005; RFS2 in 2007) were enacted. The USA has transitioned from an increasing dependence on oil imports to abundant domestic oil production. In addition, increases in the use of ethanol, the main biofuel currently produced in the USA, is now limited by the blend wall constraint. Given this, the current study evaluates alternative biofuel deployment scenarios in the USA, accounting for changes in market conditions. The analysis is performed with a general equilibrium model that reflects the structure of the USA biofuel market as the transitionmore » to advanced biofuel begins. Results suggest that ethanol consumption would increase, albeit slowly, if current biofuel deployment rates of about 10% are maintained as persistently lower oil prices lead to a gradual increase in the consumption of liquid transportation fuels. Without the blend wall constraint, this study finds that the overall economic impact of a full implementation of the USA RFS2 policy is largely neutral before 2022. However, the economic impacts become slightly negative under the blend wall constraint since more expensive bio-hydrocarbons are needed to meet the RFS2 mandates. Results for a scenario with reduced advanced biofuel deployment based on current policy plans show near neutral economic impacts up to 2027. This scenario is also consistent with another scenario where the volume of bio-hydrocarbons deployed is reduced to adjust for its higher cost and energy content relative to deploying the mandated RFS2 advanced biofuel volumes as ethanol. The important role of technological change is demonstrated under pioneer and accelerated technology scenarios, with the latter leading to neutral or positive economic effects up to 2023 under most blend wall scenarios. Here, all scenarios evaluated in this study are found to have positive long-term economic benefits for the USA economy.« less

An economic evaluation of alternative biofuel deployment scenarios in the USA

DOE PAGES

Oladosu, Gbadebo

2017-05-03

Energy market conditions have shifted dramatically since the USA renewable fuel standards (RFS1 in 2005; RFS2 in 2007) were enacted. The USA has transitioned from an increasing dependence on oil imports to abundant domestic oil production. In addition, increases in the use of ethanol, the main biofuel currently produced in the USA, is now limited by the blend wall constraint. Given this, the current study evaluates alternative biofuel deployment scenarios in the USA, accounting for changes in market conditions. The analysis is performed with a general equilibrium model that reflects the structure of the USA biofuel market as the transitionmore » to advanced biofuel begins. Results suggest that ethanol consumption would increase, albeit slowly, if current biofuel deployment rates of about 10% are maintained as persistently lower oil prices lead to a gradual increase in the consumption of liquid transportation fuels. Without the blend wall constraint, this study finds that the overall economic impact of a full implementation of the USA RFS2 policy is largely neutral before 2022. However, the economic impacts become slightly negative under the blend wall constraint since more expensive bio-hydrocarbons are needed to meet the RFS2 mandates. Results for a scenario with reduced advanced biofuel deployment based on current policy plans show near neutral economic impacts up to 2027. This scenario is also consistent with another scenario where the volume of bio-hydrocarbons deployed is reduced to adjust for its higher cost and energy content relative to deploying the mandated RFS2 advanced biofuel volumes as ethanol. The important role of technological change is demonstrated under pioneer and accelerated technology scenarios, with the latter leading to neutral or positive economic effects up to 2023 under most blend wall scenarios. Here, all scenarios evaluated in this study are found to have positive long-term economic benefits for the USA economy.« less

Neutral Beam Development for the Lockheed Martin Compact Fusion Reactor

NASA Astrophysics Data System (ADS)

Ebersohn, Frans; Sullivan, Regina

2017-10-01

The Compact Fusion Reactor project at Lockheed Martin Skunk Works is developing a neutral beam injection system for plasma heating. The neutral beam plasma source consists of a high current lanthanum hexaboride (LaB6) hollow cathode which drives an azimuthal cusp discharge similar to gridded ion thrusters. The beam is extracted with a set of focusing grids and is then neutralized in a chamber pumped with Titanium gettering. The design, testing, and analyses of individual components are presented along with the most current full system results. The goal of this project is to advance in-house neutral beam expertise at Lockheed Martin to aid in operation, procurement, and development of neutral beam technology. ©2017 Lockheed Martin Corporation. All Rights Reserved.

Development of a High-Content Orthopoxvirus Infectivity and Neutralization Assays

PubMed Central

Gates, Irina; Olson, Victoria; Smith, Scott; Patel, Nishi; Damon, Inger; Karem, Kevin

2015-01-01

Currently, a number of assays measure Orthopoxvirus neutralization with serum from individuals, vaccinated against smallpox. In addition to the traditional plaque reduction neutralization test (PRNT), newer higher throughput assays are based on neutralization of recombinant vaccinia virus, expressing reporter genes such as β-galactosidase or green fluorescent protein. These methods could not be used to evaluate neutralization of variola virus, since genetic manipulations of this virus are prohibited by international agreements. Currently, PRNT is the assay of choice to measure neutralization of variola virus. However, PRNT assays are time consuming, labor intensive, and require considerable volume of serum sample for testing. Here, we describe the development of a high-throughput, cell-based imaging assay that can be used to measure neutralization, and characterize replication kinetics of various Orthopoxviruses, including variola, vaccinia, monkeypox, and cowpox. PMID:26426117

Effectiveness of a single day induction programme in changing medical students’ attitudes towards the speciality of forensic psychiatry

PubMed Central

Archer, Ann; Guliani, Joshana; Johns, Francesca; McCartney, Emily; Smith, E Naomi; Ross, Callum C; Sengupta, Samrat; Das, Mrigendra

2016-01-01

Objectives: We aimed to investigate the effectiveness of a day visit in changing attitudes towards a high-security forensic psychiatric hospital, with regard to the current recruitment difficulties in psychiatry. Methods: Broadmoor Hospital, a UK high-security psychiatric hospital, runs day visits for medical students, led by doctors. At the beginning and the end of the day students wrote their responses to the question, ‘What do you think of Broadmoor?’ Attitudes and themes were identified, and their prevalence was analysed. Results: The responses of 296 students were initially analysed; however, 19 responses had to be excluded because they were illegible or incomplete. Before the visit, 15 responses were rated as positive, 169 neutral and 93 negative. After the visit, 205 responses were positive, 69 neutral and three negative. The themes that changed markedly following the visit were those indicating a change to favourable attitude. Conclusions: A single day visit was shown to be effective in altering the attitudes of medical students towards forensic psychiatry within a high-security psychiatric hospital. PMID:27683656

Social Anxiety and Biased Recall of Positive Information: It's Not the Content, It's the Valence.

PubMed

Glazier, Brianne L; Alden, Lynn E

2017-07-01

Cognitive theorists hypothesize that individuals with social anxiety are prone to memory biases such that event recall becomes more negative over time. With few exceptions, studies have focused primarily on changes in negative self-judgments. The current study examined whether memory for positive social events is also subject to recall bias. Undergraduate participants (N = 138) engaged in an unexpected public speaking task and received standardized positive or neutral feedback on their performance. They rated their memory of the received feedback following a 5-minute delay and again 1 week later. Results revealed that higher scores on social anxiety symptoms predicted significant reductions in the recalled valence of positive feedback over time, whereas no changes were observed for neutral feedback. The results suggest that social anxiety may lead to erosion in memory of positive events. Copyright © 2016. Published by Elsevier Ltd.

Controlled flavour changing neutral couplings in two Higgs Doublet models

NASA Astrophysics Data System (ADS)

Alves, Joao M.; Botella, Francisco J.; Branco, Gustavo C.; Cornet-Gomez, Fernando; Nebot, Miguel

2017-09-01

We propose a class of two Higgs doublet models where there are flavour changing neutral currents (FCNC) at tree level, but under control due to the introduction of a discrete symmetry in the full Lagrangian. It is shown that in this class of models, one can have simultaneously FCNC in the up and down sectors, in contrast to the situation encountered in the renormalisable and minimal flavour violating 2HDM models put forward by Branco et al. (Phys Lett B 380:119, 1996). The intensity of FCNC is analysed and it is shown that in this class of models one can respect all the strong constraints from experiment without unnatural fine-tuning. It is pointed out that the additional sources of flavour and CP violation are such that they can enhance significantly the generation of the Bbaryon asymmetry of the Universe, with respect to the standard model.

The effects of neutral inertia on ionospheric currents in the high-latitude thermosphere following a geomagnetic storm

NASA Technical Reports Server (NTRS)

Deng, W.; Killeen, T. L.; Burns, A. G.; Roble, R. G.; Slavin, J. A.; Wharton, L. E.

1993-01-01

Neutral flywheel effects are investigated in NCAR-TIGCM simulation of geomagnetic storms that occurred in November 23, 1982 and December 7-8, 1982. Theoretical calculations from the latter storm are compared with measurements of currents form instruments on the Dynamics Explorer 2 satellite. It is concluded that neutral flywheel effects can make a contribution to high latitude electrodynamics for a few hours after the main phase of a geomagnetic storm. The Hall currents that are driven by neutral winds during B(Z) northward conditions are generally in the opposite direction to those that occur during B(Z) southward conditions, when they are driven primarily by ion winds. The morphology of the field-aligned current system calculated by the NCAR-TIGCM during southward B(Z) conditions is in general agreement with observations.

NON-NEUTRALIZED ELECTRIC CURRENT PATTERNS IN SOLAR ACTIVE REGIONS: ORIGIN OF THE SHEAR-GENERATING LORENTZ FORCE

DOE Office of Scientific and Technical Information (OSTI.GOV)

Georgoulis, Manolis K.; Titov, Viacheslav S.; Mikic, Zoran

Using solar vector magnetograms of the highest available spatial resolution and signal-to-noise ratio, we perform a detailed study of electric current patterns in two solar active regions (ARs): a flaring/eruptive and a flare-quiet one. We aim to determine whether ARs inject non-neutralized (net) electric currents in the solar atmosphere, responding to a debate initiated nearly two decades ago that remains inconclusive. We find that well-formed, intense magnetic polarity inversion lines (PILs) within ARs are the only photospheric magnetic structures that support significant net current. More intense PILs seem to imply stronger non-neutralized current patterns per polarity. This finding revises previousmore » works that claim frequent injections of intense non-neutralized currents by most ARs appearing in the solar disk but also works that altogether rule out injection of non-neutralized currents. In agreement with previous studies, we also find that magnetically isolated ARs remain globally current-balanced. In addition, we confirm and quantify the preference of a given magnetic polarity to follow a given sense of electric currents, indicating a dominant sense of twist in ARs. This coherence effect is more pronounced in more compact ARs with stronger PILs and must be of sub-photospheric origin. Our results yield a natural explanation of the Lorentz force, invariably generating velocity and magnetic shear along strong PILs, thus setting a physical context for the observed pre-eruption evolution in solar ARs.« less

Observations of ELM stabilization during neutral beam injection in DIII-D

NASA Astrophysics Data System (ADS)

Bortolon, Alessandro; Kramer, Gerrit; Diallo, Ahmed; Knolker, Matthias; Maingi, Rajesh; Nazikian, Raffi; Degrassie, John; Osborne, Thomas

2017-10-01

Edge localized modes (ELMs) are generally interpreted as peeling-ballooning instabilities, driven by the pedestal current and pressure gradient, with other subdominant effects possibly relevant close to marginal stability. We report observations of transient stabilization of type-I ELMs during neutral beam injection (NBI), emerging from a combined dataset of DIII-D ELMy H-mode plasmas with moderate heating obtained through pulsed NBI waveforms. Statistical analysis of ELM onset times indicates that, in the selected dataset, the likelihood of onset of an ELM lowers significantly during NBI modulation pulses, with the stronger correlation found with counter-current NBI. The effect is also found in rf-heated H-modes, where ELMs appear inhibited when isolated diagnostic beam pulses are applied. Coherent average analysis is used to determine how plasma density, temperature, rotation as well as beam ion quantities evolve during a NB modulation cycle, finding relatively small changes ( 3%) of pedestal Te and ne and toroidal and poloidal rotation variations up to 5 km/s. The effect of these changes on pedestal stability will be discussed. Work supported by US DOE under DE-FC02-04ER54698, DE-AC02-09CH11466.

Search for the flavor-changing neutral current interactions of the top quark and the Higgs boson which decays into a pair of b quarks at $$\\sqrt{s}=$$ 13 TeV

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sirunyan, Albert M; et al.

A search for flavor-changing neutral currents (FCNC) in events with the top quark and the Higgs boson is presented. The Higgs boson decay to a pair of b quarks is considered. The data sample corresponds to an integrated luminosity of 35.9 fbmore » $$^{-1}$$ recorded by the CMS experiment at the LHC in proton-proton collisions at $$\\sqrt{s}=$$ 13 TeV. Two channels are considered: single top quark FCNC production in association with the Higgs boson (pp $$\\to$$ tH), and top quark pair production with FCNC decay of the top quark (t $$\\to$$ qH). Final states with one isolated lepton and at least three reconstructed jets, among which at least two are associated with b quarks, are studied. No significant deviation is observed from the predicted background. Observed (expected) upper limits at 95% confidence level are set on the branching fractions of top quark decays, $$\\mathcal{B}$$(t $$\\to$$ uH) $<$0.47% (0.34%) and $$\\mathcal{B}$$(t $$\\to$$ cH) $<$ 0.47% (0.44%), assuming a single nonzero FCNC coupling.« less

Method and apparatus for reducing the harmonic currents in alternating-current distribution networks

DOEpatents

Beverly, Leon H.; Hance, Richard D.; Kristalinski, Alexandr L.; Visser, Age T.

1996-01-01

An improved apparatus and method reduce the harmonic content of AC line and neutral line currents in polyphase AC source distribution networks. The apparatus and method employ a polyphase Zig-Zag transformer connected between the AC source distribution network and a load. The apparatus and method also employs a mechanism for increasing the source neutral impedance of the AC source distribution network. This mechanism can consist of a choke installed in the neutral line between the AC source and the Zig-Zag transformer.

Method and apparatus for reducing the harmonic currents in alternating-current distribution networks

DOEpatents

Beverly, L.H.; Hance, R.D.; Kristalinski, A.L.; Visser, A.T.

1996-11-19

An improved apparatus and method reduce the harmonic content of AC line and neutral line currents in polyphase AC source distribution networks. The apparatus and method employ a polyphase Zig-Zag transformer connected between the AC source distribution network and a load. The apparatus and method also employs a mechanism for increasing the source neutral impedance of the AC source distribution network. This mechanism can consist of a choke installed in the neutral line between the AC source and the Zig-Zag transformer. 23 figs.

Observation of increased space-charge limited thermionic electron emission current by neutral gas ionization in a weakly-ionized deuterium plasma

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hollmann, E. M.; Yu, J. H.; Doerner, R. P.

2015-09-14

The thermionic electron emission current emitted from a laser-produced hot spot on a tungsten target in weakly-ionized deuterium plasma is measured. It is found to be one to two orders of magnitude larger than expected for bipolar space charge limited thermionic emission current assuming an unperturbed background plasma. This difference is attributed to the plasma being modified by ionization of background neutrals by the emitted electrons. This result indicates that the allowable level of emitted thermionic electron current can be significantly enhanced in weakly-ionized plasmas due to the presence of large neutral densities.

Neural mechanisms of symptom improvements in generalized anxiety disorder following mindfulness training☆☆☆

PubMed Central

Hölzel, Britta K.; Hoge, Elizabeth A.; Greve, Douglas N.; Gard, Tim; Creswell, J. David; Brown, Kirk Warren; Barrett, Lisa Feldman; Schwartz, Carl; Vaitl, Dieter; Lazar, Sara W.

2013-01-01

Mindfulness training aims to impact emotion regulation. Generalized anxiety disorder (GAD) symptoms can be successfully addressed through mindfulness-based interventions. This preliminary study is the first to investigate neural mechanisms of symptom improvements in GAD following mindfulness training. Furthermore, we compared brain activation between GAD patients and healthy participants at baseline. 26 patients with a current DSM-IV GAD diagnosis were randomized to an 8-week Mindfulness Based Stress Reduction (MBSR, N = 15) or a stress management education (SME, N = 11) active control program. 26 healthy participants were included for baseline comparisons. BOLD response was assessed with fMRI during affect labeling of angry and neutral facial expressions. At baseline, GAD patients showed higher amygdala activation than healthy participants in response to neutral, but not angry faces, suggesting that ambiguous stimuli reveal stronger reactivity in GAD patients. In patients, amygdala activation in response to neutral faces decreased following both interventions. BOLD response in ventrolateral prefrontal regions (VLPFC) showed greater increase in MBSR than SME participants. Functional connectivity between amygdala and PFC regions increased significantly pre- to post-intervention within the MBSR, but not SME group. Both, change in VLPFC activation and amygdala–prefrontal connectivity were correlated with change in Beck Anxiety Inventory (BAI) scores, suggesting clinical relevance of these changes. Amygdala–prefrontal connectivity turned from negative coupling (typically seen in down-regulation of emotions), to positive coupling; potentially suggesting a unique mechanism of mindfulness. Findings suggest that in GAD, mindfulness training leads to changes in fronto-limbic areas crucial for the regulation of emotion; these changes correspond with reported symptom improvements. PMID:24179799

Donor understanding and attitudes about current and potential deferral criteria for high-risk sexual behavior.

PubMed

Goldman, Mindy; Yi, Qi-Long; Ye, Xibiao; Tessier, Lorna; O'Brien, Sheila F

2011-08-01

Few donor criteria are as contentious as the deferral of men who have had sex with men (MSM). We performed an anonymous donor survey to determine attitudes toward current screening and the feasibility and acceptability of adoption of alternate donor criteria for MSM. Donors who had successfully donated to Canadian Blood Services were randomly mailed an anonymous questionnaire several weeks after donation; there were 40,000 donors sampled, evenly split between first-time and repeat donors. The response rate was 45.5%. The vast majority of donors found the current screening questions and clinic environment acceptable. Attention to clinic educational materials was poor. A total of 53% felt that the MSM criteria should be changed; many were supportive of criteria based on specific behaviors rather than a period of abstinence. Gender-neutral questions such as number of sexual partners would result in deferral of large numbers of donors. Many donors would support a change in MSM deferral policy. Implementation of strategies based on donor attention to additional material would be challenging. Universal use of simple gender-neutral questions would result in very high donor loss and are therefore not an acceptable option. The acceptability and feasibility of various screening approaches should be explored further with both donors and advocacy groups. © 2011 American Association of Blood Banks.

Generation of Currents in Weakly Ionized Plasmas through a Collisional Dynamo

NASA Astrophysics Data System (ADS)

Dimant, Yakov; Oppenheim, Meers; Fletcher, Alex

2016-10-01

Intense electric currents called electrojets occur in weakly ionized magnetized plasmas. An example occurs in the Earth's ionosphere near the magnetic equator where neutral winds drive the plasma across the geomagnetic field. Similar processes take place in the Solar chromosphere and MHD generators. We argue that not all convective neutral flows generate electrojets and it introduces the corresponding universal criterion for the current formation, ∇ × (U-> × B->) ≠ ∂ B-> / ∂ t , where U-> is the neutral flow velocity, B-> is the magnetic field, and t is time. This criterion does not depend on the conductivity tensor, σ̂ . For many systems, the displacement current, ∂ B-> / ∂ t , is negligible, making the criterion even simpler. This theory also shows that the neutral-dynamo driver that generates electrojets plays the same role as the DC electric current plays for the generation of the magnetic field in the Biot-Savart law. Work supported by NSF/DOE Grant PHY-1500439.

Neutrality between Government and Religion.

ERIC Educational Resources Information Center

Mawdsley, Ralph D.

1996-01-01

The overall guiding principle of neutrality between government and religion masks a tension that exists between free exercise of religion and establishment of religion. Reviews the development and current status of "Lemon" as a test for neutrality; proposes a new test for neutrality, evenhandedness, that is common to both the Free…

Measurement of the neutrino neutral-current elastic differential cross section on mineral oil at Eν˜1GeV

NASA Astrophysics Data System (ADS)

Aguilar-Arevalo, A. A.; Anderson, C. E.; Bazarko, A. O.; Brice, S. J.; Brown, B. C.; Bugel, L.; Cao, J.; Coney, L.; Conrad, J. M.; Cox, D. C.; Curioni, A.; Dharmapalan, R.; Djurcic, Z.; Finley, D. A.; Fleming, B. T.; Ford, R.; Garcia, F. G.; Garvey, G. T.; Grange, J.; Green, C.; Green, J. A.; Hart, T. L.; Hawker, E.; Imlay, R.; Johnson, R. A.; Karagiorgi, G.; Kasper, P.; Katori, T.; Kobilarcik, T.; Kourbanis, I.; Koutsoliotas, S.; Laird, E. M.; Linden, S. K.; Link, J. M.; Liu, Y.; Liu, Y.; Louis, W. C.; Mahn, K. B. M.; Marsh, W.; Mauger, C.; McGary, V. T.; McGregor, G.; Metcalf, W.; Meyers, P. D.; Mills, F.; Mills, G. B.; Monroe, J.; Moore, C. D.; Mousseau, J.; Nelson, R. H.; Nienaber, P.; Nowak, J. A.; Osmanov, B.; Ouedraogo, S.; Patterson, R. B.; Pavlovic, Z.; Perevalov, D.; Polly, C. C.; Prebys, E.; Raaf, J. L.; Ray, H.; Roe, B. P.; Russell, A. D.; Sandberg, V.; Schirato, R.; Schmitz, D.; Shaevitz, M. H.; Shoemaker, F. C.; Smith, D.; Soderberg, M.; Sorel, M.; Spentzouris, P.; Spitz, J.; Stancu, I.; Stefanski, R. J.; Sung, M.; Tanaka, H. A.; Tayloe, R.; Tzanov, M.; van de Water, R. G.; Wascko, M. O.; White, D. H.; Wilking, M. J.; Yang, H. J.; Zeller, G. P.; Zimmerman, E. D.

2010-11-01

We report a measurement of the flux-averaged neutral-current elastic differential cross section for neutrinos scattering on mineral oil (CH2) as a function of four-momentum transferred squared, Q2. It is obtained by measuring the kinematics of recoiling nucleons with kinetic energy greater than 50 MeV which are readily detected in MiniBooNE. This differential cross-section distribution is fit with fixed nucleon form factors apart from an axial mass MA that provides a best fit for MA=1.39±0.11GeV. Using the data from the charged-current neutrino interaction sample, a ratio of neutral-current to charged-current quasielastic cross sections as a function of Q2 has been measured. Additionally, single protons with kinetic energies above 350 MeV can be distinguished from neutrons and multiple nucleon events. Using this marker, the strange quark contribution to the neutral-current axial vector form factor at Q2=0, Δs, is found to be Δs=0.08±0.26.

Vaccination of rhesus macaques with the anthrax vaccine adsorbed vaccine produces a serum antibody response that effectively neutralizes receptor-bound protective antigen in vitro.

PubMed

Clement, Kristin H; Rudge, Thomas L; Mayfield, Heather J; Carlton, Lena A; Hester, Arelis; Niemuth, Nancy A; Sabourin, Carol L; Brys, April M; Quinn, Conrad P

2010-11-01

Anthrax toxin (ATx) is composed of the binary exotoxins lethal toxin (LTx) and edema toxin (ETx). They have separate effector proteins (edema factor and lethal factor) but have the same binding protein, protective antigen (PA). PA is the primary immunogen in the current licensed vaccine anthrax vaccine adsorbed (AVA [BioThrax]). AVA confers protective immunity by stimulating production of ATx-neutralizing antibodies, which could block the intoxication process at several steps (binding of PA to the target cell surface, furin cleavage, toxin complex formation, and binding/translocation of ATx into the cell). To evaluate ATx neutralization by anti-AVA antibodies, we developed two low-temperature LTx neutralization activity (TNA) assays that distinguish antibody blocking before and after binding of PA to target cells (noncomplexed [NC] and receptor-bound [RB] TNA assays). These assays were used to investigate anti-PA antibody responses in AVA-vaccinated rhesus macaques (Macaca mulatta) that survived an aerosol challenge with Bacillus anthracis Ames spores. Results showed that macaque anti-AVA sera neutralized LTx in vitro, even when PA was prebound to cells. Neutralization titers in surviving versus nonsurviving animals and between prechallenge and postchallenge activities were highly correlated. These data demonstrate that AVA stimulates a myriad of antibodies that recognize multiple neutralizing epitopes and confirm that change, loss, or occlusion of epitopes after PA is processed from PA83 to PA63 at the cell surface does not significantly affect in vitro neutralizing efficacy. Furthermore, these data support the idea that the full-length PA83 monomer is an appropriate immunogen for inclusion in next-generation anthrax vaccines.

Optimizing personalized normative feedback: the use of gender-specific referents.

PubMed

Lewis, Melissa A; Neighbors, Clayton

2007-03-01

Many brief interventions include personalized normative feedback (PNF) using gender-specific or gender-neutral referents. Several theories suggest that information pertaining to more socially proximal referents should have greater influence on one's behavior compared with more socially distal referents. The current research evaluated whether gender specificity of the normative referent employed in PNF related to intervention efficacy. Following baseline assessment, 185 college students (45.2% women) were randomly assigned to one of three intervention conditions: gender-specific feedback, gender-neutral feedback, or assessment-only control. Immediately after completing measures of perceived norms, alcohol consumption, and gender identity, participants in the gender-neutral and gender-specific intervention conditions were provided with computerized information detailing their own drinking behavior, their perceptions of student drinking, and actual student drinking. After a 1-month follow-up, the results indicated that normative feedback was effective in changing perceived norms and reducing alcohol consumption for both intervention groups for women and men. The results provide support, however, for changes in perceived gender-specific norms as a mediator of the effects of normative feedback on reduced drinking behavior for women only. Additionally, gender-specific feedback was found to be more effective for women higher in gender identity, relative to the gender-neutral feedback. A post-assessment follow-up telephone survey administered to assess potential demand characteristics corroborated the intervention effects. Results extend previous research documenting efficacy of computer delivered PNF. Gender specificity and gender identity appear to be important elements to consider for PNF intervention efficacy for women.

Magnetic reconnection in the low solar chromosphere with a more realistic radiative cooling model

NASA Astrophysics Data System (ADS)

Ni, Lei; Lukin, Vyacheslav S.; Murphy, Nicholas A.; Lin, Jun

2018-04-01

Magnetic reconnection is the most likely mechanism responsible for the high temperature events that are observed in strongly magnetized locations around the temperature minimum in the low solar chromosphere. This work improves upon our previous work [Ni et al., Astrophys. J. 852, 95 (2018)] by using a more realistic radiative cooling model computed from the OPACITY project and the CHIANTI database. We find that the rate of ionization of the neutral component of the plasma is still faster than recombination within the current sheet region. For low β plasmas, the ionized and neutral fluid flows are well-coupled throughout the reconnection region resembling the single-fluid Sweet-Parker model dynamics. Decoupling of the ion and neutral inflows appears in the higher β case with β0=1.46 , which leads to a reconnection rate about three times faster than the rate predicted by the Sweet-Parker model. In all cases, the plasma temperature increases with time inside the current sheet, and the maximum value is above 2 ×104 K when the reconnection magnetic field strength is greater than 500 G. While the more realistic radiative cooling model does not result in qualitative changes of the characteristics of magnetic reconnection, it is necessary for studying the variations of the plasma temperature and ionization fraction inside current sheets in strongly magnetized regions of the low solar atmosphere. It is also important for studying energy conversion during the magnetic reconnection process when the hydrogen-dominated plasma approaches full ionization.

Neutral beam monitoring

DOEpatents

Fink, Joel H.

1981-08-18

Method and apparatus for monitoring characteristics of a high energy neutral beam. A neutral beam is generated by passing accelerated ions through a walled cell containing a low energy neutral gas, such that charge exchange neutralizes the high energy ion beam. The neutral beam is monitored by detecting the current flowing through the cell wall produced by low energy ions which drift to the wall after the charge exchange. By segmenting the wall into radial and longitudinal segments various beam conditions are further identified.

Interaction of a neutral cloud moving through a magnetized plasma

NASA Technical Reports Server (NTRS)

Goertz, C. K.; Lu, G.

1990-01-01

Current collection by outgassing probes in motion relative to a magnetized plasma may be significantly affected by plasma processes that cause electron heating and cross field transport. Simulations of a neutral gas cloud moving across a static magnetic field are discussed. The authors treat a low-Beta plasma and use a 2-1/2 D electrostatic code linked with the authors' Plasma and Neutral Interaction Code (PANIC). This study emphasizes the understanding of the interface between the neutral gas cloud and the surrounding plasma where electrons are heated and can diffuse across field lines. When ionization or charge exchange collisions occur a sheath-like structure is formed at the surface of the neutral gas. In that region the crossfield component of the electric field causes the electron to E times B drift with a velocity of the order of the neutral gas velocity times the square root of the ion to electron mass ratio. In addition a diamagnetic drift of the electron occurs due to the number density and temperature inhomogeneity in the front. These drift currents excite the lower-hybrid waves with the wave k-vectors almost perpendicular to the neutral flow and magnetic field again resulting in electron heating. The thermal electron current is significantly enhanced due to this heating.

Heavy Higgs searches: flavour matters

NASA Astrophysics Data System (ADS)

Gori, Stefania; Grojean, Christophe; Juste, Aurelio; Paul, Ayan

2018-01-01

We point out that the stringent lower bounds on the masses of additional electrically neutral and charged Higgs bosons crucially depend on the flavour structure of their Yukawa interactions. We show that these bounds can easily be evaded by the introduction of flavour-changing neutral currents in the Higgs sector. As an illustration, we study the phenomenology of a two Higgs doublet model with a Yukawa texture singling out the third family of quarks and leptons. We combine constraints from low-energy flavour physics measurements, LHC measurements of the 125 GeV Higgs boson rates, and LHC searches for new heavy Higgs bosons. We propose novel LHC searches that could be performed in the coming years to unravel the existence of these new Higgs bosons.

Semialigned two Higgs doublet model

NASA Astrophysics Data System (ADS)

Haba, Naoyuki; Umeeda, Hiroyuki; Yamada, Toshifumi

2018-02-01

In the left-right symmetric model based on S U (2 )L×S U (2 )R×U (1 )B -L gauge symmetry, there appear heavy neutral scalar particles mediating quark flavor changing neutral currents (FCNCs) at tree level. We consider a situation where such FCNCs give the only sign of the left-right model while WR gauge boson is decoupled, and name it "semialigned two Higgs doublet model" because the model resembles a two Higgs doublet model with mildly aligned Yukawa couplings to quarks. We predict a correlation among processes induced by quark FCNCs in the model, and argue that future precise calculation of meson-antimeson mixings and C P violation therein may hint at the semialigned two Higgs doublet model and the left-right model behind it.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Park, Chong Shik; Shiltsev, Vladimir; Stancari, Giulio

The ability to transport a high current proton beam in a ring is ultimately limited by space charge effects. Two novel ways to overcome this limit in a proton ring are by adding low energy, externally matched electron beams (electron lens, e-lens), and by taking advantage of residual gas ionization induced neutralization to create an electron column (e-column). Theory predicts that an appropriately confined electrons can completely compensate the space charge through neutralization, both transversely and longitudinally. In this report, we will discuss the current status of the Fermilab’s e-lens experiment for the space charge compensation. In addition, we willmore » show how the IOTA e-column compensates space charge with theWARP simulations. The dynamics of proton beams inside of the e-column is understood by changing the magnetic field of a solenoid, the voltage on the electrodes, and the vacuum pressure, and by looking for electron accumulation, as well as by considering various beam dynamics in the IOTA ring.« less

Additional extensions to the NASCAP computer code, volume 3

NASA Technical Reports Server (NTRS)

Mandell, M. J.; Cooke, D. L.

1981-01-01

The ION computer code is designed to calculate charge exchange ion densities, electric potentials, plasma temperatures, and current densities external to a neutralized ion engine in R-Z geometry. The present version assumes the beam ion current and density to be known and specified, and the neutralizing electrons to originate from a hot-wire ring surrounding the beam orifice. The plasma is treated as being resistive, with an electron relaxation time comparable to the plasma frequency. Together with the thermal and electrical boundary conditions described below and other straightforward engine parameters, these assumptions suffice to determine the required quantities. The ION code, written in ASCII FORTRAN for UNIVAC 1100 series computers, is designed to be run interactively, although it can also be run in batch mode. The input is free-format, and the output is mainly graphical, using the machine-independent graphics developed for the NASCAP code. The executive routine calls the code's major subroutines in user-specified order, and the code allows great latitude for restart and parameter change.

Impact of host cell variation on the neutralization of HIV-1 in vitro.

PubMed

Polonis, Victoria R; Schuitemaker, Hanneke; Bunnik, Evelien M; Brown, Bruce K; Scarlatti, Gabriella

2009-09-01

In this review we present current advances in our understanding of HIV-1 neutralization assays that employ primary cell types, as compared with those that utilize cell lines and the newer, more standardized pseudovirus assays. A commentary on the challenges of standardizing in-vitro neutralization assays using primary cells is included. The data from reporter cell line neutralization assays may agree with results observed in primary cells; however, exceptions have recently been reported. Multiple variables exist in primary cell assays using peripheral blood mononuclear cells from HIV-seronegative donors; in-vitro neutralization titers can vary significantly based on the donor cells used for assay targets and for virus propagation. Thus, more research is required to achieve validated primary cell neutralization assays. HIV-vaccine-induced antibody performance in the current neutralization assays may function as a 'gatekeeper' for HIV-1 subunit vaccine advancement. Development of standardized platforms for reproducible measurement of in-vitro neutralization is therefore a high priority. Given the considerable variation in results obtained from some widely applied HIV neutralization platforms, parallel evaluation of new antibodies using different host cells for assay targets, as well as virus propagation, is recommended until immune correlates of protection are identified.

Modeling of the coupled magnetospheric and neutral wind dynamos

NASA Technical Reports Server (NTRS)

Thayer, Jeff P.

1993-01-01

The solar wind interaction with the earth's magnetosphere generates electric fields and currents that flow from the magnetosphere to the ionosphere at high latitudes. Consequently, the neutral atmosphere is subject to the dissipation and conversion of this electrical energy to thermal and mechanical energy through Joule heating and Lorentz forcing. As a result of the mechanical energy stored within the neutral wind (caused in part by Lorentz--and pressure gradient--forces set up by the magnetospheric flux of electrical energy), electric currents and fields can be generated in the ionosphere through the neutral wind dynamo mechanism. At high latitudes this source of electrical energy has been largely ignored in past studies, owing to the assumed dominance of the solar wind/magnetospheric dynamo as an electrical energy source to the ionosphere. However, other researchers have demonstrated that the available electrical energy provided by the neutral wind is significant at high latitudes, particularly in the midnight sector of the polar cap and in the region of the magnetospheric convection reversal. As a result, the conclusions of a number of broad ranging high-latitude investigations may be modified if the neutral-wind contribution to high-latitude electrodynamics is properly accounted for. These include the following: studies assessing solar wind-magnetospheric coupling by comparing the cross polar cap potential with solar wind parameters; research based on the alignment of particle precipitation with convection or field aligned current boundaries; and synoptic investigations attributing seasonal variations in the observed electric field and current patterns to external sources. These research topics have been initiated by satellite and ground-based observations and have been attributed to magnetospheric causes. However, the contribution of the neutral wind to the high-latitude electric field and current systems and their seasonal and local time dependence has yet to be quantitatively evaluated. In this program, we are evaluating the coupled magnetospheric and neutral wind dynamos at high latitudes under various conditions. In addition to examining the impact of seasonal variations, we are investigating the consequences of the separate dynamos having pure current-source or voltage-source behaviors.

Chemical Reactions Triggered Using Electrons Photodetached from "Clean" Distributions of Anions Deposited in Cryogenic Matrices via Counterion Codeposition.

PubMed

Ludwig, Ryan M; Moore, David T

2014-09-04

Application of matrix isolation spectroscopy to ionic species is typically complicated by the presence of neutral contaminants during matrix deposition. Herein we demonstrate that simultaneous deposition of balanced currents of counterions with mass-selected ions of interest generates "clean" distributions of matrix-isolated metal carbonyl anions, where the only bands appearing in the CO-stretching region of the vibrational spectrum arise from ions. (Neutrals are initially absent.) Photodetachment by mild irradiation with visible light leads to complete conversion of the anions into their corresponding neutral species. The photodetached electrons, in turn, initiate covalent chemistry, inducing C-C bond formation following electron-capture by CO van der Waals dimers to produce trans-OCCO(-). The initial clean distribution of ions enables clear connections to be drawn between the spectral changes occurring at each experimental step, thus demonstrating the potential of the counterion codeposition technique to facilitate detailed studies of chemistry involving ions and electron transfer in cryogenic matrices.

Low energy ion distribution measurements in Madison Symmetric Torus plasmas

DOE Office of Scientific and Technical Information (OSTI.GOV)

Titus, J. B., E-mail: jtitus@cepast.famu.edu; Mezonlin, E. D.; Johnson, J. A.

2014-06-15

Charge-exchange neutrals contain information about the contents of a plasma and can be detected as they escape confinement. The Florida A and M University compact neutral particle analyzer (CNPA), used to measure the contents of neutral particle flux, has been reconfigured, calibrated, and installed on the Madison Symmetric Torus (MST) for high temperature deuterium plasmas. The energy range of the CNPA has been extended to cover 0.34–5.2 keV through an upgrade of the 25 detection channels. The CNPA has been used on all types of MST plasmas at a rate of 20 kHz throughout the entire discharge (∼70 ms). Plasma parameter scans showmore » that the ion distribution is most dependent on the plasma current. Magnetic reconnection events throughout these scans produce stronger poloidal electric fields, stronger global magnetic modes, and larger changes in magnetic energy all of which heavily influence the non-Maxwellian part of the ion distribution (the fast ion tail)« less

Dieting and Food Cue-Related Working Memory Performance.

PubMed

Meule, Adrian

2016-01-01

Executive functioning (e.g., working memory) is tightly intertwined with self-regulation. For example, food cue-elicited craving has been found to impair working memory performance. Furthermore, current dieters have been found to show lower working memory performance than non-dieters. Recent research, however, suggests that it is crucial to consider dieting success in addition to current dieting status or restrained eating in order to reveal cognitive mechanisms that are associated with successful eating-related self-regulation. The current study investigated food cue-related working memory performance as a function of dieting status and dieting success in female students. Participants performed an n -back task with pictures of food and neutral objects. Reaction time in response to food pictures was slower than in response to neutral pictures, whereas omission errors did not differ between picture types. Current food craving was increased after performing the food block, but not after the neutral block. There was an indirect effect of current dieting status on higher food craving after the food block, which was mediated by slower reaction time to food vs. neutral pictures. Furthermore, higher dieting success was associated with fewer omission errors in the food vs. neutral block in current dieters. There were no relationships of restrained eating with current food craving and task performance. Results further highlight the need to differentiate between successful and unsuccessful dieting in addition to current dieting status or restrained eating when examining possible mechanisms of overeating or successful restraint. Although palatable food cues induce food craving regardless of dieting success, they may boost executive functioning in successful dieters, which helps them to overcome these temptations.

Investigating the polar ionosphere during the development of neutral density enhancements on 24-25 September 2000

NASA Astrophysics Data System (ADS)

Horvath, Ildiko; Lovell, Brian C.

2017-04-01

We focus on the well-known northern daytime neutral density spikes detected by CHAMP on 25 September 2000 and related coupled magnetospheric-ionospheric-thermospheric processes. We investigate the underlying magnetic events and resultant thermospheric variations plus the state of the ionospheric polar region by employing multi-instrument CHAMP and DMSP data. Results show the unfolding of a weak (SYM-HMin ≈ -27 nT; 0345 UT) magnetic storm during which these northern density spikes occurred. Some smaller southern daytime density spikes were also detected prior to this storm on the previous day. All these density spikes were detected in or near polar convection flow channels (FCs). Each FC was characterized by strong antisunward zonal ion drifts that excited the zonal and meridional neutral winds leaving the signature of FC in the CHAMP neutral wind measurements and thus providing direct observational evidence of FC underlying the density spike. Additional to the small-scale field-aligned current (SS-FAC) filaments, the sudden intensifications of ionospheric closure current in the FC fueled the thermosphere and contributed to the development of upwelling and density spike. Some smaller density increases occurred due to the weak intensification of ionospheric closure currents. Equatorward (poleward) directed meridional neutral winds strengthened (weakened) the density spike by moving the neutral density up and along (down and against) the upwelling fueled by the ionospheric closure current and SS-FAC filaments.

Adaptive Fuzzy Hysteresis Band Current Controller for Four-Wire Shunt Active Filter

NASA Astrophysics Data System (ADS)

Hamoudi, F.; Chaghi, A.; Amimeur, H.; Merabet, E.

2008-06-01

This paper presents an adaptive fuzzy hysteresis band current controller for four-wire shunt active power filters to eliminate harmonics and to compensate reactive power in distribution systems in order to keep currents at the point of common coupling sinusoidal and in phase with the corresponding voltage and the cancel neutral current. The conventional hysteresis band known for its robustness and its advantage in current controlled applications is adapted with a fuzzy logic controller to change the bandwidth according to the operating point in order to keep the frequency modulation at tolerable limits. The algorithm used to identify the reference currents is based on the synchronous reference frame theory (dqγ). Finally, simulation results using Matlab/Simulink are given to validate the proposed control.

Measurement of the neutral to charged current cross section ratios for neutrino and and antineutrino interactions on protons

NASA Astrophysics Data System (ADS)

Jones, G. T.; Jones, R. W. L.; Kennedy, B. W.; O'Neale, S. W.; Hoffmann, E.; Haidt, D.; Klein, H.; Mittendorfer, J.; Morrison, D. R. O.; Schmid, P.; Wachsmuth, H.; Hamisi, F.; Miller, D. B.; Mobayyen, M. M.; Aderholz, M.; Deck, L.; Schmitz, N.; Wittek, W.; Corrigan, G.; Myatt, G.; Radojicic, D.; Retter, M. L.; Saitta, B.; Shotton, P. N.; Towers, S. J.; Bullock, F. W.; Burke, S.; Fitch, P. J.; Birmingham-Bonn-CERN-Imperial College-München(MPI)-Oxford-University College Collaboration

1986-10-01

The ratios Rvp and Rvp of the neutral current to charged current cross sections for neutrino and antineutrino interactions on protons have been measured in BEBC. The beam was the CERN SPS 400 GeV wideband beam. The bubble chamber, equipped with the standard External Muon Identifier, was surrounded with an additional plane of wire chambers (Internal Picket Fence), which was added to improve neutral current event identification. For a total transverse momentum of the charged hadrons above 0.45 GeV/ c and a charged multiplicity of at least 3, it was found that R vp = 0.384 ± 0.015 and R vp = 0.338 ± 0.014 ± 0.016, corresponding to a value of sin 2θ w(M woverlineMSof 0.225 ± 0.030 . Combining the results from hydrogen and an isoscalar target, the differences of the neutral current chiral coupling constants were found to be u2l- d2L = -0.080 ± 0.043 ± 0.012 and u2R- d2R = 0.021±0.055±0.028.

Measurement of Neutral-Current K+ Production by Neutrinos using MINERvA

NASA Astrophysics Data System (ADS)

Marshall, C. M.; Aliaga, L.; Altinok, O.; Bellantoni, L.; Bercellie, A.; Betancourt, M.; Bodek, A.; Bravar, A.; Cai, T.; Carneiro, M. F.; da Motta, H.; Dytman, S. A.; Díaz, G. A.; Dunkman, M.; Eberly, B.; Endress, E.; Felix, J.; Fields, L.; Fine, R.; Gago, A. M.; Galindo, R.; Gallagher, H.; Ghosh, A.; Golan, T.; Gran, R.; Harris, D. A.; Higuera, A.; Hurtado, K.; Kleykamp, J.; Kordosky, M.; Le, T.; Maher, E.; Manly, S.; Mann, W. A.; Caicedo, D. A. Martinez; McFarland, K. S.; McGivern, C. L.; McGowan, A. M.; Messerly, B.; Miller, J.; Mislivec, A.; Morfín, J. G.; Mousseau, J.; Naples, D.; Nelson, J. K.; Norrick, A.; Nuruzzaman; Paolone, V.; Patrick, C. E.; Perdue, G. N.; Ramírez, M. A.; Ransome, R. D.; Ray, H.; Ren, L.; Rimal, D.; Rodrigues, P. A.; Ruterbories, D.; Schmitz, D. W.; Solano Salinas, C. J.; Sultana, M.; Sánchez Falero, S.; Valencia, E.; Walton, T.; Wolcott, J.; Wospakrik, M.; Yaeggy, B.; Zhang, D.; Minerva Collaboration

2017-07-01

Neutral-current production of K+ by atmospheric neutrinos is a background in searches for the proton decay p →K+ν ¯. Reactions such as ν p →ν K+Λ are indistinguishable from proton decays when the decay products of the Λ are below detection threshold. Events with K+ are identified in MINERvA by reconstructing the timing signature of a K+ decay at rest. A sample of 201 neutrino-induced neutral-current K+ events is used to measure differential cross sections with respect to the K+ kinetic energy, and the non-K+ hadronic visible energy. An excess of events at low hadronic visible energy is observed relative to the prediction of the neut event generator. Good agreement is observed with the cross section prediction of the genie generator. A search for photons from π0 decay, which would veto a neutral-current K+ event in a proton decay search, is performed, and a 2 σ deficit of detached photons is observed relative to the genie prediction.

Measurement of Neutral-Current K + Production by Neutrinos using MINERvA

DOE Office of Scientific and Technical Information (OSTI.GOV)

Marshall, C. M.; Aliaga, L.; Altinok, O.

Neutral-current production of K+ by atmospheric neutrinos is a background in searches for the proton decay p→K+ν¯. Reactions such as νp→νK+Λ are indistinguishable from proton decays when the decay products of the Λ are below detection threshold. Events with K+ are identified in MINERvA by reconstructing the timing signature of a K+ decay at rest. A sample of 201 neutrino-induced neutral-current K+ events is used to measure differential cross sections with respect to the K+ kinetic energy, and the non-K+ hadronic visible energy. An excess of events at low hadronic visible energy is observed relative to the prediction of themore » neut event generator. Good agreement is observed with the cross section prediction of the genie generator. A search for photons from π0 decay, which would veto a neutral-current K+ event in a proton decay search, is performed, and a 2σ deficit of detached photons is observed relative to the genie prediction.« less

Amygdala activation as a marker for selective attention toward neutral faces in a chronic traumatic brain injury population.

PubMed

Young, Leanne R; Yu, Weikei; Holloway, Michael; Rodgers, Barry N; Chapman, Sandra B; Krawczyk, Daniel C

2017-09-01

There has been great interest in characterizing the response of the amygdala to emotional faces, especially in the context of social cognition. Although amygdala activation is most often associated with fearful or angry stimuli, there is considerable evidence that the response of the amygdala to neutral faces is both robust and reliable. This characteristic of amygdala function is of particular interest in the context of assessing populations with executive function deficits, such as traumatic brain injuries, which can be evaluated using fMRI attention modulation tasks that evaluate prefrontal control over representations, notably faces. The current study tested the hypothesis that the amygdala may serve as a marker of selective attention to neutral faces. Using fMRI, we gathered data within a chronic traumatic brain injury population. Blood Oxygenation Level Dependent (BOLD) signal change within the left and right amygdalae and fusiform face areas was measured while participants viewed neutral faces and scenes, under conditions requiring participants to (1) categorize pictures of faces and scenes, (2) selectively attend to either faces or scenes, or (3) attend to both faces and scenes. Findings revealed that the amygdala is an effective marker for selective attention to neutral faces and, furthermore, it was more face-specific than the fusiform face area. Copyright © 2017 Elsevier Ltd. All rights reserved.

Isolated effects of external bath osmolality, solute concentration, and electrical charge on solute transport across articular cartilage.

PubMed

Pouran, Behdad; Arbabi, Vahid; Zadpoor, Amir A; Weinans, Harrie

2016-12-01

The metabolic function of cartilage primarily depends on transport of solutes through diffusion mechanism. In the current study, we use contrast enhanced micro-computed tomography to determine equilibrium concentration of solutes through different cartilage zones and solute flux in the cartilage, using osteochondral plugs from equine femoral condyles. Diffusion experiments were performed with two solutes of different charge and approximately equal molecular weight, namely iodixanol (neutral) and ioxaglate (charge=-1) in order to isolate the effects of solute's charge on diffusion. Furthermore, solute concentrations as well as bath osmolality were changed to isolate the effects of steric hindrance on diffusion. Bath concentration and bath osmolality only had minor effects on the diffusion of the neutral solute through cartilage at the surface, middle and deep zones, indicating that the diffusion of the neutral solute was mainly Fickian. The negatively charged solute diffused considerably slower through cartilage than the neutral solute, indicating a large non-Fickian contribution in the diffusion of charged molecules. The numerical models determined maximum solute flux in the superficial zone up to a factor of 2.5 lower for the negatively charged solutes (charge=-1) as compared to the neutral solutes confirming the importance of charge-matrix interaction in diffusion of molecules across cartilage. Copyright © 2016 IPEM. Published by Elsevier Ltd. All rights reserved.

Current collection from an unmagnetized plasma: A tutorial

NASA Technical Reports Server (NTRS)

Whipple, Elden C.

1990-01-01

The current collected by a body in an unmagnetized plasma depends in general on: (1) the properties of the plasma; (2) the properties of the body; and (3) the properties of any neutral species that are present. The important plasma properties are the velocity distributions of the plasma particles at a location remote from the body (at infinity), and the Debye length which determines the importance of plasma space charge effects. The important body properties are its surface characteristics, namely the conductivity and secondary yield coefficients. The neutral species affect the current through collisions which impede the flow of current and possibly through ionization of the neutrals which can enhance the current. The technique for calculating the current collected by a body in a plasma is reviewed with special attention given to the distinction between orbit limited and space charge limited regimes, the asymptotic variation of the potential with distance from a body, and the concept of a sheath.

Study of the Rare Decay B Mesons Decaying to X Mesons Positive And Negative Leptons at BABAR

DOE Office of Scientific and Technical Information (OSTI.GOV)

Koptchev, Ventzislav B.; /Massachusetts U., Amherst

2005-08-30

Flavor-changing neutral current transitions are forbidden at tree level in the Standard Model and can only occur via higher order diagrams. Since the amplitudes for such loops are dominated by the heaviest known particles, and non-SM effects are expected to contribute at the same order as the SM, such processes are an ideal place to look for new physics. We present a measurement of the inclusive branching fraction for the flavor-changing neutral current process B {yields} X{sub s}{ell}{sup +}{ell}{sup -} with a sample of 81.9 fb{sup -1}, collected with the BABAR detector at the Stanford Linear Accelerator Center. The finalmore » state is reconstructed from e{sup +}e{sup -} or {mu}{sup +}{mu}{sup -} pairs and a hadronic system consisting of one K{sup {+-}} or K{sub s} and up to two pions, with at most one {pi}{sup 0}. They observe a signal of 40 {+-} 10(stat) {+-} 2(syst) events and extract a branching fraction {Beta}(B {yields} X{sub s}{ell}{sup +}{ell}{sup -}) = (5.6 {+-} 1.5(stat) {+-} 0.6(exp. syst) {+-} 1.1(model syst)) x 10{sup -6} for m{sub ll} > 0.2 GeV.« less

New vector-like fermions and flavor physics

DOE PAGES

Ishiwata, Koji; Ligeti, Zoltan; Wise, Mark B.

2015-10-06

We study renormalizable extensions of the standard model that contain vector-like fermions in a (single) complex representation of the standard model gauge group. There are 11 models where the vector-like fermions Yukawa couple to the standard model fermions via the Higgs field. These models do not introduce additional fine-tunings. They can lead to, and are constrained by, a number of different flavor-changing processes involving leptons and quarks, as well as direct searches. An interesting feature of the models with strongly interacting vector-like fermions is that constraints from neutral meson mixings (apart from CP violation inmore » $$ {K}^0-{\\overline{K}}^0 $$ mixing) are not sensitive to higher scales than other flavor-changing neutral-current processes. We identify order 1/(4πM) 2 (where M is the vector-like fermion mass) one-loop contributions to the coefficients of the four-quark operators for meson mixing, that are not suppressed by standard model quark masses and/or mixing angles.« less

Snake-venom resistance as a mammalian trophic adaptation: lessons from didelphid marsupials.

PubMed

Voss, Robert S; Jansa, Sharon A

2012-11-01

Mammals that prey on venomous snakes include several opossums (Didelphidae), at least two hedgehogs (Erinaceidae), several mongooses (Herpestidae), several mustelids, and some skunks (Mephitidae). As a group, these taxa do not share any distinctive morphological traits. Instead, mammalian adaptations for ophiophagy seem to consist only in the ability to resist the toxic effects of snake venom. Molecular mechanisms of venom resistance (as indicated by biochemical research on opossums, mongooses, and hedgehogs) include toxin-neutralizing serum factors and adaptive changes in venom-targeted molecules. Of these, toxin-neutralizing serum factors have received the most research attention to date. All of the toxin-neutralizing serum proteins discovered so far in both opossums and mongooses are human α1B-glycoprotein homologs that inhibit either snake-venom metalloproteinases or phospholipase A(2) myotoxins. By contrast, adaptive changes in venom-targeted molecules have received far less attention. The best-documented examples include amino-acid substitutions in mongoose nicotinic acetylcholine receptor that inhibit binding by α-neurotoxins, and amino-acid substitutions in opossum von Willebrand factor (vWF) that are hypothesized to weaken the bond between vWF and coagulopathic C-type lectins. Although multiple mechanisms of venom resistance are known from some species, the proteomic complexity of most snake venoms suggests that the evolved biochemical defences of ophiophagous mammals are likely to be far more numerous than currently recognized. Whereas most previous research in this field has been motivated by the potential for medical applications, venom resistance in ophiophagous mammals is a complex adaptation that merits attention from comparative biologists. Unfortunately, evolutionary inference is currently limited by ignorance about many relevant facts that can only be provided by future research. © 2012 The Authors. Biological Reviews © 2012 Cambridge Philosophical Society.

Fearful, but not angry, expressions diffuse attention to peripheral targets in an attentional blink paradigm.

PubMed

Taylor, James M; Whalen, Paul J

2014-06-01

We previously demonstrated that fearful facial expressions implicitly facilitate memory for contextual events whereas angry facial expressions do not. The current study sought to more directly address the implicit effect of fearful expressions on attention for contextual events within a classic attentional paradigm (i.e., the attentional blink) in which memory is tested on a trial-by-trial basis, thereby providing subjects with a clear, explicit attentional strategy. Neutral faces of a single gender were presented via rapid serial visual presentation (RSVP) while bordered by four gray pound signs. Participants were told to watch for a gender change within the sequence (T1). It is critical to note that the T1 face displayed a neutral, fearful, or angry expression. Subjects were then told to detect a color change (i.e., gray to green; T2) at one of the four peripheral pound sign locations appearing after T1. This T2 color change could appear at one of six temporal positions. Complementing previous attentional blink paradigms, participants were told to respond via button press immediately when a T2 target was detected. We found that, compared with the neutral T1 faces, fearful faces significantly increased target detection ability at four of the six temporal locations (all ps < .05) whereas angry expressions did not. The results of this study demonstrate that fearful facial expressions can uniquely and implicitly enhance environmental monitoring above and beyond explicit attentional effects related to task instructions.

Antigenic analysis of genetic variants of Canine distemper virus.

PubMed

Anis, Eman; Holford, Amy L; Galyon, Gina D; Wilkes, Rebecca P

2018-06-01

Canine distemper virus (CDV) is an RNA virus of the genus Morbillivirus within the family Paramyxoviridae. CDV produces multi-systemic disease in dogs and other terrestrial carnivores. With the development of modified live vaccines in the 1950s and 1960s, the disease, with a few exceptions, has been successfully controlled. However, recently the cases of CDV in vaccinated dogs have been increasing throughout the world, including the United States. There are many reasons that can lead to vaccine failure, including antigenic differences between the vaccine strains and the currently circulating wild-type strains. Currently, there are at least three genetically different CDV lineages circulating in the US. Therefore, in this study, we evaluated various wild-type CDV and vaccine isolates to determine if the genetic differences observed among various strains result in significant antigenic differences based on changes to the neutralizing epitopes. The results of a cross-neutralization assay revealed that there are antigenic differences among the tested CDV wild-type isolates as well as between the tested isolates and the vaccine strains currently used in the US. Therefore, these results suggest the need to develop an updated CDV vaccine. Copyright © 2018 Elsevier B.V. All rights reserved.

Measurements of Ion and Neutral Fluctuation Changes with Pressure in a Large-Scale Helicon Plasma

NASA Astrophysics Data System (ADS)

Dwyer, R. H.; Fisher, D. M.; Kelly, R. F.; Hatch, M. W.; Gilmore, M.

2017-10-01

Neutral particle dynamics may play an important role both in laboratory plasmas and in the edge of magnetic fusion devices. However, studies of neutral dynamics in these plasmas have been limited to date. Here we report on a basic study of ion and neutral fluctuations as a function of background neutral gas pressure. These experiments have been conducted in helicon discharges in the HelCat (Helicon-Cathode) dual-source plasma device at the University of New Mexico. The goal is to measure changes in ion and neutral density fluctuations with pressure and to gain an improved understanding of plasma-neutral interactions. Langmuir probe, Ar-I LIF, and high-speed imaging measurements of the fluctuations will be presented. Supported by U.S. National Science Foundation Award 1500423 and The University of New Mexico School of Engineering.

The terrestrial ring current - From in situ measurements to global images using energetic neutral atoms

NASA Technical Reports Server (NTRS)

Roelof, Edmond C.; Williams, Donald J.

1988-01-01

Electrical currents flowing in the equatorial magnetosphere, first inferred from ground-based magnetic disturbances, are carried by trapped energetic ions. Spacecraft measurements have determined the spectrum and composition of those currents, and the newly developed technique of energetic-neutral-atom imaging allows the global dynamics of that entire ion population to be viewed from a single spacecraft.

Beyond ITER: neutral beams for a demonstration fusion reactor (DEMO) (invited).

PubMed

McAdams, R

2014-02-01

In the development of magnetically confined fusion as an economically sustainable power source, International Tokamak Experimental Reactor (ITER) is currently under construction. Beyond ITER is the demonstration fusion reactor (DEMO) programme in which the physics and engineering aspects of a future fusion power plant will be demonstrated. DEMO will produce net electrical power. The DEMO programme will be outlined and the role of neutral beams for heating and current drive will be described. In particular, the importance of the efficiency of neutral beam systems in terms of injected neutral beam power compared to wallplug power will be discussed. Options for improving this efficiency including advanced neutralisers and energy recovery are discussed.

CP Violation, Neutral Currents, and Weak Equivalence

DOE R&D Accomplishments Database

Fitch, V. L.

1972-03-23

Within the past few months two excellent summaries of the state of our knowledge of the weak interactions have been presented. Correspondingly, we will not attempt a comprehensive review but instead concentrate this discussion on the status of CP violation, the question of the neutral currents, and the weak equivalence principle.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Baroni, A.; Schiavilla, R.

Cross sections for inclusive neutrino scattering off deuteron induced by neutral and charge-changing weak currents are calculated from threshold up to 150 MeV energies in a chiral effective field theory including high orders in the power counting. The contributions beyond leading order (LO) in the weak current are found to be small, and increase the cross sections obtained with the LO transition operators by a couple of percent over the whole energy range (0--150) MeV. Furthermore, the cutoff dependence is negligible, and the predicted cross sections are within ~2% of, albeit consistently larger than, corresponding predictions obtained in conventional meson-exchangemore » frameworks.« less

Optimizing Personalized Normative Feedback: The Use of Gender-Specific Referents*

PubMed Central

LEWIS, MELISSA A.; NEIGHBORS, CLAYTON

2008-01-01

Objective Many brief interventions include personalized normative feedback (PNF) using gender-specific or gender-neutral referents. Several theories suggest that information pertaining to more socially proximal referents should have greater influence on one’s behavior compared with more socially distal referents. The current research evaluated whether gender specificity of the normative referent employed in PNF related to intervention efficacy. Method Following baseline assessment, 185 college students (45.2% women) were randomly assigned to one of three intervention conditions: gender-specific feedback, gender-neutral feedback, or assessment-only control. Immediately after completing measures of perceived norms, alcohol consumption, and gender identity, participants in the gender-neutral and gender-specific intervention conditions were provided with computerized information detailing their own drinking behavior, their perceptions of student drinking, and actual student drinking. Results After a 1-month follow-up, the results indicated that normative feedback was effective in changing perceived norms and reducing alcohol consumption for both intervention groups for women and men. The results provide support, however, for changes in perceived gender-specific norms as a mediator of the effects of normative feedback on reduced drinking behavior for women only. Additionally, gender-specific feedback was found to be more effective for women higher in gender identity, relative to the gender-neutral feedback. A post-assessment follow-up telephone survey administered to assess potential demand characteristics corroborated the intervention effects. Conclusions Results extend previous research documenting efficacy of computer delivered PNF. Gender specificity and gender identity appear to be important elements to consider for PNF intervention efficacy for women. PMID:17286341

Transport Experiments on Topological Insulators

DTIC Science & Technology

2016-08-16

neutral currents as well. In insulating magnets, the heat current below 2 K is largely carried by spin waves or magnons (phonons die out rapidly below 2 K...Ong’s group recently showed that  leads to prominent effects on neutral currents as well. In insulating magnets, the heat current below 2 K is...UU UU UU 16-08-2016 15-Sep-2011 14-Oct-2014 Final Report: Transport Experiments on Topological Insulators The views, opinions and/or findings contained

Improvement of a plasma uniformity of the 2nd ion source of KSTAR neutral beam injector.

PubMed

Jeong, S H; Kim, T S; Lee, K W; Chang, D H; In, S R; Bae, Y S

2014-02-01

The 2nd ion source of KSTAR (Korea Superconducting Tokamak Advanced Research) NBI (Neutral Beam Injector) had been developed and operated since last year. A calorimetric analysis revealed that the heat load of the back plate of the ion source is relatively higher than that of the 1st ion source of KSTAR NBI. The spatial plasma uniformity of the ion source is not good. Therefore, we intended to identify factors affecting the uniformity of a plasma density and improve it. We estimated the effects of a direction of filament current and a magnetic field configuration of the plasma generator on the plasma uniformity. We also verified that the operation conditions of an ion source could change a uniformity of the plasma density of an ion source.

A non-equilibrium neutral model for analysing cultural change.

PubMed

Kandler, Anne; Shennan, Stephen

2013-08-07

Neutral evolution is a frequently used model to analyse changes in frequencies of cultural variants over time. Variants are chosen to be copied according to their relative frequency and new variants are introduced by a process of random mutation. Here we present a non-equilibrium neutral model which accounts for temporally varying population sizes and mutation rates and makes it possible to analyse the cultural system under consideration at any point in time. This framework gives an indication whether observed changes in the frequency distributions of a set of cultural variants between two time points are consistent with the random copying hypothesis. We find that the likelihood of the existence of the observed assemblage at the end of the considered time period (expressed by the probability of the observed number of cultural variants present in the population during the whole period under neutral evolution) is a powerful indicator of departures from neutrality. Further, we study the effects of frequency-dependent selection on the evolutionary trajectories and present a case study of change in the decoration of pottery in early Neolithic Central Europe. Based on the framework developed we show that neutral evolution is not an adequate description of the observed changes in frequency. Copyright © 2013 Elsevier Ltd. All rights reserved.

Modeling of the Coupled Magnetospheric and Neutral Wind Dynamos

NASA Technical Reports Server (NTRS)

Thayer, Jeffrey P.

1997-01-01

Over the past four years of funding, SRI, in collaboration with the University of Texas at Dallas, has been involved in assessing the influence of thermospheric neutral winds on the electric field and current systems at high latitudes. The initial direction of the project was to perform a set of numerical experiments concerning the contribution of the magnetospheric and neutral wind dynamo processes, under specific boundary conditions, to the polarization electric field and/or the field-aligned current distribution at high latitudes. To facilitate these numerical experiments we developed a numerical scheme that relied on using output from the NCAR Thermosphere-Ionosphere General Circulation Model (NCAR-TIGCM), expanding them in the form of spherical harmonics and solving the dynamo equations spectrally. Once initial calculations were completed, it was recognized that the neutral wind contribution could be significant but its actual contribution to the electric field or currents depended strongly on the generator properties of the magnetosphere. Solutions to this problem are not unique because of the unknown characteristics of the magnetospheric generator, therefore the focus was on two limiting cases. One limiting case was to consider the magnetosphere as a voltage generator delivering a fixed voltage to the high-latitude ionosphere and allowing for the neutral wind dynamo to contribute only to the current system. The second limiting case was to consider the magnetosphere as a current generator and allowing for the neutral wind dynamo to contribute only to the generation of polarization electric fields. This work was completed and presented at the l994 Fall AGU meeting. The direction of the project then shifted to applying the Poynting flux concept to the high-latitude ionosphere. This concept was more attractive as it evaluated the influence of neutral winds on the high-latitude electrodynamics without actually having to determine the generator characteristics of the magnetosphere. The influence of the neutral wind was then determined not by estimating how much electric potential or current density it provides, but by determining the contribution of the neutral wind to the net electromagnetic energy transferred between the ionosphere and magnetosphere. The estimate of the net electromagnetic energy transfer and the role of the neutral winds proves to be a more fundamental quantity in studies of magnetosphere- ionosphere coupling also showed that by using electric and magnetic field measurements from the HILAT satellite, the Poynting flux could be a measurable quantity from polar-orbiting, low- altitude spacecraft. Through collaboration with Dr. Heelis and others at UTD and their expertise of the electric field measurements on the DE-B satellite, an extensive analysis was planned to determine the Poynting flux from the DE-B measurements in combination with a modeling effort to help interpret the observations taking into account the coupled magnetosphere-ionosphere.

Coordinated observations of postmidnight irregularities and thermospheric neutral winds and temperatures at low latitudes

NASA Astrophysics Data System (ADS)

Dao, Tam; Otsuka, Yuichi; Shiokawa, Kazuo; Nishioka, Michi; Yamamoto, Mamoru; Buhari, Suhaila M.; Abdullah, Mardina; Husin, Asnawi

2017-07-01

We investigated a postmidnight field-aligned irregularity (FAI) event observed with the Equatorial Atmosphere Radar at Kototabang (0.2°S, 100.3°E, dip latitude 10.4°S) in Indonesia on the night of 9 July 2010 using a comprehensive data set of both neutral and plasma parameters. We examined the rate of total electron content change index (ROTI) obtained from GPS receivers in Southeast Asia, airglow images detected by an all-sky imager, and thermospheric neutral winds and temperatures obtained by a Fabry-Perot interferometer at Kototabang. Altitudes of the F layer (h'F) observed by ionosondes at Kototabang, Chiang Mai, and Chumphon were also surveyed. We found that the postmidnight FAIs occurred within plasma bubbles and coincided with kilometer-scale plasma density irregularities. We also observed an enhancement of the magnetically equatorward thermospheric neutral wind at the same time as the increase of h'F at low-latitude stations, but h'F at a station near the magnetic equator remained invariant. Simultaneously, a magnetically equatorward gradient of thermospheric temperature was identified at Kototabang. The convergence of equatorward neutral winds from the Northern and Southern Hemispheres could be associated with a midnight temperature maximum occurring around the magnetic equator. Equatorward neutral winds can uplift the F layer at low latitudes and increase the growth rate of Rayleigh-Taylor instabilities, causing more rapid extension of plasma bubbles. The equatorward winds in both hemispheres also intensify the eastward Pedersen current, so a large polarization electric field generated in the plasma bubble might play an important role in the generation of postmidnight FAIs.

The influence of current neutralization and multiple Coulomb scattering on the spatial dynamics of resistive sausage instability of a relativistic electron beam propagating in ohmic plasma

NASA Astrophysics Data System (ADS)

Kolesnikov, E. K.; Manuilov, A. S.; Petrov, V. S.; Klyushnikov, G. N.; Chernov, S. V.

2017-06-01

The influence of the current neutralization process, the phase mixing of the trajectories of electrons and multiple Coulomb scattering of electrons beam on the atoms of the background medium on the spatial increment of the growth of sausage instability of a relativistic electron beam propagating in ohmic plasma channel has been considered. It has been shown that the amplification of the current neutralization leads to a significant increase in this instability, and phase mixing and the process of multiple scattering of electrons beam on the atoms of the background medium are the stabilizing factor.

Role of the E2 Hypervariable Region (HVR1) in the Immunogenicity of a Recombinant Hepatitis C Virus Vaccine

PubMed Central

2018-01-01

ABSTRACT Current evidence supports a protective role for virus-neutralizing antibodies in immunity against hepatitis C virus (HCV) infection. Many cross-neutralizing monoclonal antibodies have been identified. These antibodies have been shown to provide protection or to clear infection in animal models. Previous clinical trials have shown that a gpE1/gpE2 vaccine can induce antibodies that neutralize the in vitro infectivity of all the major cell culture-derived HCV (HCVcc) genotypes around the world. However, cross-neutralization appeared to favor certain genotypes, with significant but lower neutralization against others. HCV may employ epitope masking to avoid antibody-mediated neutralization. Hypervariable region 1 (HVR1) at the amino terminus of glycoprotein E2 has been shown to restrict access to many neutralizing antibodies. Consistent with this, other groups have reported that recombinant viruses lacking HVR1 are hypersensitive to neutralization. It has been proposed that gpE1/gpE2 lacking this domain could be a better vaccine antigen to induce broadly neutralizing antibodies. In this study, we examined the immunogenicity of recombinant gpE1/gpE2 lacking HVR1 (ΔHVR1). Our results indicate that wild-type (WT) and ΔHVR1 gpE1/gpE2 antigens induced antibodies targeting many well-characterized cross-genotype-neutralizing epitopes. However, while the WT gpE1/gpE2 vaccine can induce cross-genotype protection against various genotypes of HCVcc and/or HCV-pseudotyped virus (HCVpp), antisera from ΔHVR1 gpE1/gpE2-immunized animals exhibited either reduced homologous neutralization activity compared to that of the WT or heterologous neutralization activity similar to that of the WT. These data suggest that ΔHVR1 gpE1/gpE2 is not a superior vaccine antigen. Based on previously reported chimpanzee protection data using WT gpE1/gpE2 and our current findings, we are preparing a combination vaccine including wild-type recombinant gpE1/gpE2 for clinical testing in the future. IMPORTANCE An HCV vaccine is an unmet medical need. Current evidence suggests that neutralizing antibodies play an important role in virus clearance, along with cellular immune responses. Previous clinical data showed that gpE1/gpE2 can effectively induce cross-neutralizing antibodies, although they favor certain genotypes. HCV employs HVR1 within gpE2 to evade host immune control. It has been hypothesized that the removal of this domain would improve the production of cross-neutralizing antibodies. In this study, we compared the immunogenicities of WT and ΔHVR1 gpE1/gpE2 antigens as vaccine candidates. Our results indicate that the ΔHVR1 gpE1/gpE2 antigen confers no advantages in the neutralization of HCV compared with the WT antigen. Previously, we showed that this WT antigen remains the only vaccine candidate to protect chimpanzees from chronic infection, contains multiple cross-neutralizing epitopes, and is well tolerated and immunogenic in humans. The current data support the further clinical development of this vaccine antigen component. PMID:29540595

Measurement of Neutral-Current K + Production by Neutrinos using MINERvA

DOE Office of Scientific and Technical Information (OSTI.GOV)

Marshall, C. M.; Aliaga, L.; Altinok, O.

Neutral-current production of K + by atmospheric neutrinos is a background in searches for the proton decay p → K +ν¯. Reactions such as νp → νK +Λ are indistinguishable from proton decays when the decay products of the Λ are below detection threshold. Events with K + are identified in MINERvA by reconstructing the timing signature of a K + decay at rest. A sample of 201 neutrino-induced neutral-current K + events is used to measure differential cross sections with respect to the K + kinetic energy, and the non-K + hadronic visible energy. An excess of events atmore » low hadronic visible energy is observed relative to the prediction of the neut event generator. Good agreement is observed with the cross section prediction of the genie generator. In conclusion, a search for photons from π 0 decay, which would veto a neutral-current K + event in a proton decay search, is performed, and a 2σ deficit of detached photons is observed relative to the genie prediction.« less

A current disruption mechanism in the neutral sheet - A possible trigger for substorm expansions

NASA Technical Reports Server (NTRS)

Lui, A. T. Y.; Mankofsky, A.; Chang, C.-L.; Papadopoulos, K.; Wu, C. S.

1990-01-01

A linear analysis is performed to investigate the kinetic cross-field streaming instability in the earth's magnetotail neutral sheet region. Numerical solution of the dispersion equation shows that the instability can occur under conditions expected for the neutral sheet just prior to the onset of substorm expansion. The excited waves are obliquely propagating whistlers with a mixed polarization in the lower hybrid frequency range. The ensuing turbulence of this instability can lead to a local reduction of the cross-tail current causing it to continue through the ionosphere to form a substorm current wedge. A substorm expansion onset scenario is proposed based on this instability in which the relative drift between ions and electrons is primarily due to unmagnetized ions undergoing current sheet acceleration in the presence of a cross-tail electric field. The required electric field strength is within the range of electric field values detected in the neutral sheet region during substorm intervals. The skew in local time of substorm onset location and the three conditions under which substorm onset is observed can be understood on the basis of the proposed scenario.

Measurement of Neutral-Current K + Production by Neutrinos using MINERvA

DOE PAGES

Marshall, C. M.; Aliaga, L.; Altinok, O.; ...

2017-07-07

Neutral-current production of K + by atmospheric neutrinos is a background in searches for the proton decay p → K +ν¯. Reactions such as νp → νK +Λ are indistinguishable from proton decays when the decay products of the Λ are below detection threshold. Events with K + are identified in MINERvA by reconstructing the timing signature of a K + decay at rest. A sample of 201 neutrino-induced neutral-current K + events is used to measure differential cross sections with respect to the K + kinetic energy, and the non-K + hadronic visible energy. An excess of events atmore » low hadronic visible energy is observed relative to the prediction of the neut event generator. Good agreement is observed with the cross section prediction of the genie generator. In conclusion, a search for photons from π 0 decay, which would veto a neutral-current K + event in a proton decay search, is performed, and a 2σ deficit of detached photons is observed relative to the genie prediction.« less

Hearing taboo words can result in early talker effects in word recognition for female listeners.

PubMed

Tuft, Samantha E; MᶜLennan, Conor T; Krestar, Maura L

2018-02-01

Previous spoken word recognition research using the long-term repetition-priming paradigm found performance costs for stimuli mismatching in talker identity. That is, when words were repeated across the two blocks, and the identity of the talker changed reaction times (RTs) were slower than when the repeated words were spoken by the same talker. Such performance costs, or talker effects, followed a time course, occurring only when processing was relatively slow. More recent research suggests that increased explicit and implicit attention towards the talkers can result in talker effects even during relatively fast processing. The purpose of the current study was to examine whether word meaning would influence the pattern of talker effects in an easy lexical decision task and, if so, whether results would differ depending on whether the presentation of neutral and taboo words was mixed or blocked. Regardless of presentation, participants responded to taboo words faster than neutral words. Furthermore, talker effects for the female talker emerged when participants heard both taboo and neutral words (consistent with an attention-based hypothesis), but not for participants that heard only taboo or only neutral words (consistent with the time-course hypothesis). These findings have important implications for theoretical models of spoken word recognition.

Local context effects during emotional item directed forgetting in younger and older adults.

PubMed

Gallant, Sara N; Dyson, Benjamin J; Yang, Lixia

2017-09-01

This paper explored the differential sensitivity young and older adults exhibit to the local context of items entering memory. We examined trial-to-trial performance during an item directed forgetting task for positive, negative, and neutral (or baseline) words each cued as either to-be-remembered (TBR) or to-be-forgotten (TBF). This allowed us to focus on how variations in emotional valence (independent of arousal) and instruction (TBR vs. TBF) of the previous item (trial n-1) impacted memory for the current item (trial n) during encoding. Different from research showing impairing effects of emotional arousal, both age groups showed a memorial boost for stimuli when preceded by items high in positive or negative valence relative to those preceded by neutral items. This advantage was particularly prominent for neutral trial n items that followed emotional items suggesting that, regardless of age, neutral memories may be strengthened by a local context that is high in valence. A trending age difference also emerged with older adults showing greater sensitivity when encoding instructions changed between trial n-1 and n. Results are discussed in light of age-related theories of cognitive and emotional processing, highlighting the need to consider the dynamic, moment-to-moment fluctuations of these systems.

Energy and Pitch Distribution of Spontaneously-generated High-energy Bulk Ions in the RFP

NASA Astrophysics Data System (ADS)

Kim, Jungha; Anderson, Jay; Reusch, Joshua; Eilerman, Scott; Capecchi, William

2014-10-01

Magnetic reconnection events in the reversed field pinch (RFP) are known to heat bulk and impurity ions. Runaway due to a parallel electric field has recently been confirmed as an important acceleration mechanism for high energy test ions supplied by a neutral beam. This effect does not, however, explain the change in distribution of nearly Maxwellian bulk ions at a reconnection event. By operating MST near maximum current and low electron density, significant fusion neutron flux can be generated without neutral beam injection. The bulk ion distribution created in these plasmas is well-confined, non-Maxwellian, and can be measured by the Advanced Neutral Particle Analyzer (ANPA) placed at a radial or tangential porthole. Data show a high energy tail up to 25 keV with a relatively higher signal in the low energy channels (8-15 keV) at the radial port following a reconnection event. Analysis of the energy dependence of trapped orbits sampled by the ANPA at the radial view implies an abundance of lower energy particles in regions of higher neutral density. This mandates a careful deconvolution of the measured ANPA signal to compute the fast ion distribution. This work is supported by the US DOE and NSF.

Lighting to Make You Feel Better: Improving the Mood of Elderly People with Affective Ambiences

PubMed Central

Kuijsters, Andre; Redi, Judith; de Ruyter, Boris; Heynderickx, Ingrid

2015-01-01

Current lighting technologies extend the options for changing the appearance of rooms and closed spaces, as such creating ambiences with an affective meaning. Using intelligence, these ambiences may instantly be adapted to the needs of the room’s occupant(s), possibly improving their well-being. We hypothesized that ambiences with a clearly recognizable, positive affective meaning could be used to effectively mitigate negative mood in elderly. After inducing a sad mood with a short movie one group of elderly was immersed in a positive high arousing (i.e., activating) ambience, and another group in a neutral ambience. Similarly, after inducing anxiety with a short movie one group of elderly was immersed in a pleasant low arousing (i.e., cozy) ambience, and another group in a neutral ambience. We monitored the evolution of the mood of the four groups of elderly over a period of ten minutes after the mood induction, with both self-reported mood measurements (every 2 minutes) and constant measurements of the skin conductance response (SCR) and electrocardiography (ECG). In line with our hypothesis we found that the activating ambience was physiologically more arousing than the neutral ambience. The cozy ambience was more effective in calming anxious elderly than the neutral ambience, as reflected by both the self-reported and physiological measurements. PMID:26192281

Variability of Extreme Precipitation Events in Tijuana, Mexico During ENSO Years

NASA Astrophysics Data System (ADS)

Cavazos, T.; Rivas, D.

2007-05-01

We present the variability of daily precipitation extremes (top 10 percecnt) in Tijuana, Mexico during 1950-2000. Interannual rainfall variability is significantly modulated by El Nino/Southern Oscillation. The interannual precipitation variability exhibits a large change with a relatively wet period and more variability during 1976- 2000. The wettest years and the largest frequency of daily extremes occurred after 1976-1977, with 6 out of 8 wet years characterized by El Nino episodes and 2 by neutral conditions. However, more than half of the daily extremes during 1950-2000 occurred in non-ENSO years, evidencing that neutral conditions also contribute significantly to extreme climatic variability in the region. Extreme events that occur in neutral (strong El Nino) conditions are associated with a pineapple express and a neutral PNA (negative TNH) teleconnection pattern that links an anomalous tropical convective forcing west (east) of the date line with a strong subtropical jet over the study area. At regional scale, both types of extremes are characterized by a trough in the subtropical jet over California/Baja California, which is further intensified by thermal interaction with an anomalous warm California Current off Baja California, low-level moisture advection from the subtropical warm sea-surface region, intense convective activity over the study area and extreme rainfall from southern California to Baja California.

On the day-to-day variation of the equatorial electrojet during quiet periods

NASA Astrophysics Data System (ADS)

Yamazaki, Y.; Richmond, A. D.; Maute, A.; Liu, H.-L.; Pedatella, N.; Sassi, F.

2014-08-01

It has been known for a long time that the equatorial electrojet varies from day to day even when solar and geomagnetic activities are very low. The quiet time day-to-day variation is considered to be due to irregular variability of the neutral wind, but little is known about how variable winds drive the electrojet variability. We employ a numerical model introduced by Liu et al. (2013), which takes into account weather changes in the lower atmosphere and thus can reproduce ionospheric variability due to forcing from below. The simulation is run for May and June 2009. Constant solar and magnetospheric energy inputs are used so that day-to-day changes will arise only from lower atmospheric forcing. The simulated electrojet current shows day-to-day variability of ±25%, which produces day-to-day variations in ground level geomagnetic perturbations near the magnetic equator. The current system associated with the day-to-day variation of the equatorial electrojet is traced based on a covariance analysis. The current pattern reveals return flow at both sides of the electrojet, in agreement with those inferred from ground-based magnetometer data in previous studies. The day-to-day variation in the electrojet current is compared with those in the neutral wind at various altitudes, latitudes, and longitudes. It is found that the electrojet variability is dominated by the zonal wind at 100-120 km altitudes near the magnetic equator. These results suggest that the response of the zonal polarization electric field to variable zonal winds is the main source of the day-to-day variation of the equatorial electrojet during quiet periods.

Using arterial spin labeling to examine mood states in youth.

PubMed

Mikita, Nina; Mehta, Mitul A; Zelaya, Fernando O; Stringaris, Argyris

2015-06-01

Little is known about the neural correlates of mood states and the specific physiological changes associated with their valence and duration, especially in young people. Arterial spin labeling (ASL) imaging is particularly well-suited to study sustained cerebral states in young people, due to its robustness to low-frequency drift, excellent interscan reliability, and noninvasiveness. Yet, it has so far been underutilized for understanding the neural mechanisms underlying mood states in youth. In this exploratory study, 21 healthy adolescents aged 16 to 18 took part in a mood induction experiment. Neutral, sad, and happy mood states were induced using film clips and explicit instructions. An ASL scan was obtained following presentation of each film clip. Mood induction led to robust changes in self-reported mood ratings. Compared to neutral, sad mood was associated with increased regional cerebral blood flow (rCBF) in the left middle frontal gyrus and anterior prefrontal cortex, and decreased rCBF in the right middle frontal gyrus and the inferior parietal lobule. A decrease in self-reported mood from neutral to sad condition was associated with increased rCBF in the precuneus. Happy mood was associated with increased rCBF in medial frontal and cingulate gyri, the subgenual anterior cingulate cortex, and ventral striatum, and decreased rCBF in the inferior parietal lobule. The level of current self-reported depressive symptoms was negatively associated with rCBF change in the cerebellum and lingual gyrus following both sad and happy mood inductions. Arterial spin labeling is sensitive to experimentally induced mood changes in healthy young people. The effects of happy mood on rCBF patterns were generally stronger than the effects of sad mood.

Current profile redistribution driven by neutral beam injection in a reversed-field pinch

NASA Astrophysics Data System (ADS)

Parke, E.; Anderson, J. K.; Brower, D. L.; Den Hartog, D. J.; Ding, W. X.; Johnson, C. A.; Lin, L.

2016-05-01

Neutral beam injection in reversed-field pinch (RFP) plasmas on the Madison Symmetric Torus [Dexter et al., Fusion Sci. Technol. 19, 131 (1991)] drives current redistribution with increased on-axis current density but negligible net current drive. Internal fluctuations correlated with tearing modes are observed on multiple diagnostics; the behavior of tearing mode correlated structures is consistent with flattening of the safety factor profile. The first application of a parametrized model for island flattening to temperature fluctuations in an RFP allows inferrence of rational surface locations for multiple tearing modes. The m = 1, n = 6 mode is observed to shift inward by 1.1 ± 0.6 cm with neutral beam injection. Tearing mode rational surface measurements provide a strong constraint for equilibrium reconstruction, with an estimated reduction of q0 by 5% and an increase in on-axis current density of 8% ± 5%. The inferred on-axis current drive is consistent with estimates of fast ion density using TRANSP [Goldston et al., J. Comput. Phys. 43, 61 (1981)].

Physiological and neural correlates of worry and rumination: Support for the contrast avoidance model of worry.

PubMed

Steinfurth, Elisa C K; Alius, Manuela G; Wendt, Julia; Hamm, Alfons O

2017-02-01

The current experiments tested neural and physiological correlates of worry and rumination in comparison to thinking about neutral events. According to the avoidance model-stating that worry is a strategy to reduce intense emotions-physiological and neurobiological activity during worried thinking should not differ from activation during neutral thinking. According to the contrast avoidance model-stating that worry is a strategy to reduce abrupt shifts of emotions-activity should be increased. To test these competing models, we induced worry and neutral thinking in healthy participants using personal topics. A rumination condition was added to investigate the specificity of changes induced by the mental process. Two experiments were conducted assessing the effects on different response levels: (1) neural activation using fMRI, and (2) physiological response mobilization using startle and autonomic measures. During worry, participants showed a potentiated startle response and BOLD activity indicative of emotional network activation. These data partly support the contrast avoidance model of worry. Both mental processes showed elevated activity in a common network referred to as default network indicating self-referential activity. © 2016 Society for Psychophysiological Research.

Probing Supersymmetry with Neutral Current Scattering Experiments

NASA Astrophysics Data System (ADS)

Kurylov, A.; Ramsey-Musolf, M. J.; Su, S.

2004-02-01

We compute the supersymmetric contributions to the weak charges of the electron (QWe) and proton (QWp) in the framework of Minimal Supersymmetric Standard Model. We also consider the ratio of neutral current to charged current cross sections, R v and Rv¯ at v (v¯)-nucleus deep inelastic scattering, and compare the supersymmetric corrections with the deviations of these quantities from the Standard Model predictions implied by the recent NuTeV measurement.

A comparative study on low-energy ion beam and neutralized beam modifications of naked DNA and biological effect on mutation

NASA Astrophysics Data System (ADS)

Sarapirom, S.; Thongkumkoon, P.; Prakrajang, K.; Anuntalabhochai, S.; Yu, L. D.

2012-02-01

DNA conformation change or damage induced by low-energy ion irradiation has been of great interest owing to research developments in ion beam biotechnology and ion beam application in biomedicine. Mechanisms involved in the induction of DNA damage may account for effect from implanting ion charge. In order to check this effect, we used both ion beam and neutralized beam at keV energy to bombard naked DNA. Argon or nitrogen ion beam was generated and extracted from a radiofrequency (RF) ion source and neutralized by microwave-driven plasma in the beam path. Plasmid DNA pGFP samples were irradiated with the ion or neutralized beam in vacuum, followed by gel electrophoresis to observe changes in the DNA conformations. It was revealed that the ion charge played a certain role in inducing DNA conformation change. The subsequent DNA transfer into bacteria Escherichia coli ( E. coli) for mutation analysis indicated that the charged ion beam induced DNA change had high potential in mutation induction while neutralized beam did not. The intrinsic reason was attributed to additional DNA deformation and contortion caused by ion charge exchange effect so that the ion beam induced DNA damage could hardly be completely repaired, whereas the neutralized beam induced DNA change could be more easily recoverable owing to absence of the additional DNA deformation and contortion.

The meanings of professional life: teaching across the health professions.

PubMed

Kelley, Maureen

2002-08-01

Most of professional ethics is grounded on the assumption that we can speak meaningfully about particular, insulated professions with aims and goals, that conceptually there exists a clear "inside and outside" to any given profession. Professional ethics has also inherited the two-part assumption from mainstream moral philosophy that we can speak meaningfully about agent-relative versus agent-neutral moral perspectives, and further, that it is only from the agent-neutral perspective that we can truly evaluate our professional moral aims, rules, and practices. Several important changes that have occurred, or are currently taking place, in the structure of the health care professions, challenge those assumptions and signal the need for teachers of professional ethics to rethink the content of what we teach as well as our teaching methods. The changes include: influences and critique from other professions and from those who are served by the health professions, and influences and critique from professionals themselves, including increased activism and dissent from within the professions. The discussion focuses on changes that have occurred in the health-related fields, but insofar as similar changes are occurring in other professions such as law and business, these arguments will have broader conceptual implications for the way we ought to think about professional ethics more generally.

Top quark rare decays via loop-induced FCNC interactions in extended mirror fermion model

NASA Astrophysics Data System (ADS)

Hung, P. Q.; Lin, Yu-Xiang; Nugroho, Chrisna Setyo; Yuan, Tzu-Chiang

2018-02-01

Flavor changing neutral current (FCNC) interactions for a top quark t decays into Xq with X represents a neutral gauge or Higgs boson, and q a up- or charm-quark are highly suppressed in the Standard Model (SM) due to the Glashow-Iliopoulos-Miami mechanism. Whilst current limits on the branching ratios of these processes have been established at the order of 10-4 from the Large Hadron Collider experiments, SM predictions are at least nine orders of magnitude below. In this work, we study some of these FCNC processes in the context of an extended mirror fermion model, originally proposed to implement the electroweak scale seesaw mechanism for non-sterile right-handed neutrinos. We show that one can probe the process t → Zc for a wide range of parameter space with branching ratios varying from 10-6 to 10-8, comparable with various new physics models including the general two Higgs doublet model with or without flavor violations at tree level, minimal supersymmetric standard model with or without R-parity, and extra dimension model.

Ion related problems for the XLS ring

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bozoki, E.; Halama, H.

1989-07-11

The electron beam in the XLS will collide with the residual gas in the vacuum chamber. The positive ions will be trapped in the potential well of the electron beam. They will perform stable or unstable oscillations around the beam under the repetitive Coulomb force of the bunches. If not cleared, the captured ions will lead to partial or total neutralization of the beam, causing both, a decrease of life-time and a change in the vertical tunes as well as an increase in the tune-spread. They can also cause coherent transverse instabilities. The degree of neutralization {theta} that one canmore » tolerate, is primarily determined by the allowable tune shift, which of the XLS is between 1 and 5 10{sup {minus}3}. Electrostatic clearing electrodes will be used to keep the neutralization below the desired limit. In order to determine their location and the necessary clearing-rate and voltage, we examine the ion production rate, longitudinal velocity of ions in field-free regions and in the dipoles to see what distance the ions can travel without clearing before the neutralization of the beam reaches the prescribed limit, beam potential to see the locations of the potential wells, voltage requirements for ion clearing, critical mass for ion capture in the bunched beam, tune shift caused by neutralization of the beam, pressure rise due to the trapped ions and power dissipation due to beam image current. 13 refs., 3 figs., 4 tabs.« less

Physical processes associated with current collection by plasma contactors

NASA Technical Reports Server (NTRS)

Katz, Ira; Davis, Victoria A.

1990-01-01

Recent flight data confirms laboratory observations that the release of neutral gas increases plasma sheath currents. Plasma contactors are devices which release a partially ionized gas in order to enhance the current flow between a spacecraft and the space plasma. Ionization of the expellant gas and the formation of a double layer between the anode plasma and the space plasma are the dominant physical processes. A theory is presented of the interaction between the contactor plasma and the background plasma. The conditions for formation of a double layer between the two plasmas are derived. Double layer formation is shown to be a consequence of the nonlinear response of the plasmas to changes in potential. Numerical calculations based upon this model are compared with laboratory measurements of current collection by hollow cathode-based plasma contactors.

Diurnal Variations in Global Joule Heating Morphology and Magnitude Due To Neutral Winds

NASA Astrophysics Data System (ADS)

Billett, D. D.; Grocott, A.; Wild, J. A.; Walach, M.-T.; Kosch, M. J.

2018-03-01

In the polar ionosphere, variations in Joule heating are significantly controlled by changes in plasma convection, such as that brought about by changes in the interplanetary magnetic field. However, another important consideration when calculating Joule heating is the velocity difference between this plasma and the neutral thermosphere colocated with the ionosphere. Neutral wind data are often difficult to obtain on a global scale; thus, Joule heating has often previously been calculated assuming that neutral velocities are small and can therefore be neglected. Previous work has shown the effect of neutral winds on Joule heating estimations to be more significant than originally thought; however, the diurnal variations of the neutrals due to changes in solar pressure gradients and Coriolis forces have yet to have their impact on Joule heating assessed. We show this universal time effect to be significant in calculating Joule heating and thus can differ significantly from that calculated by neglecting the neutrals. In this study, we use empirical models for the neutral wind, conductivities, and magnetic field to create Northern Hemispheric patterns of Joule heating for approximately 800,000 individual plasma convection patterns generated using data from the Super Dual Auroral Radar Network. From this, a statistical analysis of how Joule heating varies in morphology and magnitude with universal time is shown for differing seasons and levels of geomagnetic activity. We find that neutral winds do play a significant role in the morphology and total energy output of Joule heating.

Energization of Ions in near-Earth current sheet disruptions

NASA Technical Reports Server (NTRS)

Taktakishvili, A.; Lopez, R. E.; Goodrich, C. C.

1995-01-01

In this study we examine observations made by AMPTE/CCE of energetic ion bursts during seven substorm periods when the satellite was located near the neutral sheet, and CCE observed the disruption cross-tail current in situ. We compare ion observations to analytic calculations of particle acceleration. We find that the acceleration region size, which we assume to be essentially the current disruption region, to be on the order of 1 R(sub E). Events exhibiting weak acceleration had either relatively small acceleration regions (apparently associated with pseudobreakup activity on the ground) or relatively small changes in the local magnetic field (suggesting that the magnitude of the local current disruption region was limited). These results add additional support for the view that the particle bursts observed during turbulent current sheet disruptions are due to inductive acceleration of ions.

Disruption Neutral Point Experiment on Alcator C-Mod

NASA Astrophysics Data System (ADS)

Granetz, R. S.; Nakamura, Y.

2000-10-01

Disruptions of single-null elongated plasmas generally result in loss of vertical position control, leading to a current quench occurring at the top or bottom of the machine, with all the attendant problems of halo and eddy currents flowing in divertor structures. On JT-60U, it has been found that if the plasma is operated with its magnetic axis at a particular height, called the neutral point, the initial vertical drift after a thermal quench is significantly slower than usual, and sometimes can even be arrested, thereby avoiding a current quench in the divertor region entirely. In an ongoing collaboration between MIT and JAERI, the neutral point concept is being tested in Alcator C-Mod, which has a significantly higher plasma elongation than JT-60U (1.65 vs 1.3). Calculations using TSC predict a neutral point at z~=+1 cm above the midplane (a=22 cm). The existence of a neutral point has now been experimentally confirmed, albeit at a height of z=+2.7 cm. The plasma has remained vertically stable for up to 9 ms after the disruption thermal quench, which in principle, is long enough for the PF control system to respond, if programmed appropriately. In addition, the physics of the neutral point stability on C-Mod appears to be somewhat different than that on JT-60U.

Structural Basis for Escape of Human Astrovirus from Antibody Neutralization: Broad Implications for Rational Vaccine Design

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bogdanoff, Walter A.; Perez, Edmundo I.; López, Tomás

ABSTRACT Human astroviruses are recognized as a leading cause of viral diarrhea worldwide in children, immunocompromised patients, and the elderly. There are currently no vaccines available to prevent astrovirus infection; however, antibodies developed by healthy individuals during previous infection correlate with protection from reinfection, suggesting that an effective vaccine could be developed. In this study, we investigated the molecular mechanism by which several strains of human astrovirus serotype 2 (HAstV-2) are resistant to the potent HAstV-2-neutralizing monoclonal antibody PL-2 (MAb PL-2). Sequencing of the HAstV-2 capsid genes reveals mutations in the PL-2 epitope within the capsid's spike domain. To understandmore » the molecular basis for resistance from MAb PL-2 neutralization, we determined the 1.35-Å-resolution crystal structure of the capsid spike from one of these HAstV-2 strains. Our structure reveals a dramatic conformational change in a loop within the PL-2 epitope due to a serine-to-proline mutation, locking the loop in a conformation that sterically blocks binding and neutralization by MAb PL-2. We show that mutation to serine permits loop flexibility and recovers MAb PL-2 binding. Importantly, we find that HAstV-2 capsid spike containing a serine in this loop is immunogenic and elicits antibodies that neutralize all HAstV-2 strains. Taken together, our results have broad implications for rational selection of vaccine strains that do not contain prolines in antigenic loops, so as to elicit antibodies against diverse loop conformations. IMPORTANCEHuman astroviruses (HAstVs) infect nearly every person in the world during childhood and cause diarrhea, vomiting, and fever. In this study, we investigated how several strains of HAstV are resistant to a virus-neutralizing monoclonal antibody. We determined the crystal structure of the capsid protein spike domain from one of these HAstV strains and found that a single amino acid mutation induces a structural change in a loop that is responsible for antibody binding. Our findings reveal how viruses can escape antibody neutralization and provide insight for the rational design of vaccines to elicit diverse antibodies that provide broader protection from infection.« less

Static air-gap eccentricity fault diagnosis using rotor slot harmonics in line neutral voltage of three-phase squirrel cage induction motor

NASA Astrophysics Data System (ADS)

Oumaamar, Mohamed El Kamel; Maouche, Yassine; Boucherma, Mohamed; Khezzar, Abdelmalek

2017-02-01

The mixed eccentricity fault detection in a squirrel cage induction motor has been thoroughly investigated. However, a few papers have been related to pure static eccentricity fault and the authors focused on the RSH harmonics presented in stator current. The main objective of this paper is to present an alternative method based on the analysis of line neutral voltage taking place between the supply and the stator neutrals in order to detect air-gap static eccentricity, and to highlight the classification of all RSH harmonics in line neutral voltage. The model of squirrel cage induction machine relies on the rotor geometry and winding layout. Such developed model is used to analyze the impact of the pure static air-gap eccentricity by predicting the related frequencies in the line neutral voltage spectrum. The results show that the line neutral voltage spectrum are more sensitive to the air-gap static eccentricity fault compared to stator current one. The theoretical analysis and simulated results are confirmed by experiments.

Gauged lepton flavour

DOE PAGES

Alonso, Rodrigo; Fernandez Martinez, Enrique; Gavela, M. B.; ...

2016-12-22

The gauging of the lepton flavour group is considered in the Standard Model context and in its extension with three right-handed neutrinos. The anomaly cancellation conditions lead to a Seesaw mechanism as underlying dynamics for all leptons; in addition, it requires a phenomenologically viable setup which leads to Majorana masses for the neutral sector: the type I Seesaw Lagrangian in the Standard Model case and the inverse Seesaw in the extended model. Within the minimal extension of the scalar sector, the Yukawa couplings are promoted to scalar fields in the bifundamental of the flavour group. The resulting low-energy Yukawa couplingsmore » are proportional to inverse powers of the vacuum expectation values of those scalars; the protection against flavour changing neutral currents differs from that of Minimal Flavour Violation. In every case, the μ - τ flavour sector exhibits rich and promising phenomenological signals.« less

Neutral strange particle production in antineutrino-neon charged current interactions

NASA Astrophysics Data System (ADS)

Willocq, S.; Marage, P.; Aderholz, M.; Allport, P.; Baton, J. P.; Berggren, M.; Clayton, E. F.; Cooper-Sarkar, A. M.; Erriquez, O.; Faulkner, P. J. W.; Guy, J.; Hulth, P. O.; Jones, G. T.; Mobayyen, M. M.; Morrison, D. R. O.; Neveu, M.; O'Neale, S.; Sacton, J.; Sansum, R. A.; Varvell, K.; Venus, W.; Wells, J.; Wittek, W.

1992-06-01

Neutral strange particle production inbar v Ne charged current interactions is studied using the bubble chamber BEBC, exposed to the CERN SPS antineutrino wide band beam. From a sample of 1191 neutral strange particles, the inclusive production rates are determined to be (15.7±0.8)% for K 0 mesons, (8.2±0.5)% for Λ, (0.4±0.2)% forbar Λ and (0.6±0.3)% for Σ0 hyperons. The inclusive production properties of K 0 mesons and Λ hyperons are investigated. The Λ hyperons are found to be polarized in the production plane.

High-current plasma contactor neutralizer system

NASA Technical Reports Server (NTRS)

Beattie, J. R.; Williamson, W. S.; Matossian, J. N.; Vourgourakis, E. J.; Burch, J. L.

1989-01-01

A plasma-contactor neutralizer system is described, for the stabilizing the Orbiter's potential during flights of the Atmospheric Laboratory for Applications and Science missions. The plasma contactor neutralizer will include a Xe plasma source that can provide steady-state ion-emission currents of up to 1.5 A. The Orbiter's potential will be maintained near that of the surrounding space plasma during electron-beam accelerator firings through a combination of ion emission from the Xe plasma source and electron collection from the ambient space plasma. Configuration diagrams and block diagrams are presented along with the performance characteristics of the system.

How range shifts induced by climate change affect neutral evolution

PubMed Central

McInerny, G.J.; Turner, J.R.G.; Wong, H.Y.; Travis, J.M.J.; Benton, T.G.

2009-01-01

We investigate neutral evolution during range shifts in a strategic model of a metapopulation occupying a climate gradient. Using heritable, neutral markers, we track the spatio-temporal fate of lineages. Owing to iterated founder effects (‘mutation surfing’), survival of lineages derived from the leading range limit is enhanced. At trailing limits, where habitat suitability decreases, survival is reduced (mutations ‘wipe out’). These processes alter (i) the spatial spread of mutations, (ii) origins of persisting mutations and (iii) the generation of diversity. We show that large changes in neutral evolution can be a direct consequence of range shifting. PMID:19324824

How range shifts induced by climate change affect neutral evolution.

PubMed

McInerny, G J; Turner, J R G; Wong, H Y; Travis, J M J; Benton, T G

2009-04-22

We investigate neutral evolution during range shifts in a strategic model of a metapopulation occupying a climate gradient. Using heritable, neutral markers, we track the spatio-temporal fate of lineages. Owing to iterated founder effects ('mutation surfing'), survival of lineages derived from the leading range limit is enhanced. At trailing limits, where habitat suitability decreases, survival is reduced (mutations 'wipe out'). These processes alter (i) the spatial spread of mutations, (ii) origins of persisting mutations and (iii) the generation of diversity. We show that large changes in neutral evolution can be a direct consequence of range shifting.

A colored KNT neutrino model

DOE PAGES

Nomura, Takaaki; Okada, Hiroshi; Okada, Nobuchika

2016-09-22

Here, we propose a radiative seesaw model at the three-loop level, in which quarks, leptons, leptoquark bosons, and a Majorana fermion of dark matter candidate are involved in the neutrino loop. When analyzing neutrino oscillation data includes all possible constraints such as flavor changing neutral currents, lepton flavor violations, upper/lower bound on the mass of leptoquark from the collider physics, and the measured relic density of the dark matter, we show the allowed region to satisfy all the data/constraints.

Realistic anomaly-mediated supersymmetry breaking

NASA Astrophysics Data System (ADS)

Chacko, Zacharia; Luty, Markus A.; Maksymyk, Ivan; Pontón, Eduardo

2000-03-01

We consider supersymmetry breaking communicated entirely by the superconformal anomaly in supergravity. This scenario is naturally realized if supersymmetry is broken in a hidden sector whose couplings to the observable sector are suppressed by more than powers of the Planck scale, as occurs if supersymmetry is broken in a parallel universe living in extra dimensions. This scenario is extremely predictive: soft supersymmetry breaking couplings are completely determined by anomalous dimensions in the effective theory at the weak scale. Gaugino and scalar masses are naturally of the same order, and flavor-changing neutral currents are automatically suppressed. The most glaring problem with this scenario is that slepton masses are negative in the minimal supersymmetric standard model. We point out that this problem can be simply solved by coupling extra Higgs doublets to the leptons. Lepton flavor-changing neutral currents can be naturally avoided by approximate symmetries. We also describe more speculative solutions involving compositeness near the weak scale. We then turn to electroweak symmetry breaking. Adding an explicit μ term gives a value for Bμ that is too large by a factor of ~ 100. We construct a realistic model in which the μ term arises from the vacuum expectation value of a singlet field, so all weak-scale masses are directly related to m3/2. We show that fully realistic electroweak symmetry breaking can occur in this model with moderate fine-tuning.

Low-scale warped extra dimension and its predilection for multiple top quarks

NASA Astrophysics Data System (ADS)

Jung, Sunghoon; Wells, James D.

2010-11-01

Within warped extra dimension models that explain flavor through geometry, flavor changing neutral current constraints generally force the Kaluza-Klein scale to be above many TeV. This creates tension with a natural electroweak scale. On the other hand, a much lower scale compatible with precision electroweak and flavor changing neutral current constraints is allowed if we decouple the Kaluza-Klein states of Standard Model gauge bosons from light fermions ( c light ≃ c b ≃ 0 .5 bulk mass parameters). The main signature for this approach is four top quark production via the Kaluza-Klein excitations’ strong coupling to top quarks. We study single lepton, like-sign dilepton, and trilepton observables of four-top events at the Large Hadron Collider. The like-sign dilepton signature typically has the largest discovery potential for a strongly coupled right-handed top case ( M KK ˜ 2 - 2 .5 TeV), while single lepton is the better when the left-handed top couples most strongly ( M KK ˜ 2 TeV). We also describe challenging lepton-jet collimation issues in the like-sign dilepton and trilepton channels. An alternative single lepton observable is considered which takes advantage of the many bottom quarks in the final state. Although searches of other particles may compete, we find that four top production via Kaluza-Klein gluons is most promising in a large region of this parameter space.

Development of miniaturized, spectroscopically assisted Penning gauges for fractional helium and hydrogen neutral pressure measurements

DOE Office of Scientific and Technical Information (OSTI.GOV)

Flesch, K.; Kremeyer, T.; Schmitz, O.

Direct measurements of the helium (He) fractional neutral pressure in the neutral gas around fusion devices is challenging because of the small mass difference between the abundant D-2 molecules and the He ash which will be produced by deuterium-tritium fusion. In order to study He exhaust, an in situ Penning gauge system is being developed at UW-Madison that is optimized for good pressure and high spectroscopic sensitivity. There are three different anode geometries that we have studied regarding their vacuum electrostatic fields, light output, and ion current. The light output of the two new anode configurations are at least onemore » order of magnitude above the currently available designs, hence improving the spectroscopic sensitivity at similar total neutral pressure resolution.« less

Development of miniaturized, spectroscopically assisted Penning gauges for fractional helium and hydrogen neutral pressure measurements

DOE Office of Scientific and Technical Information (OSTI.GOV)

Flesch, K., E-mail: kbflesch@wisc.edu; Kremeyer, T.; Schmitz, O.

Direct measurements of the helium (He) fractional neutral pressure in the neutral gas around fusion devices is challenging because of the small mass difference between the abundant D{sub 2} molecules and the He ash which will be produced by deuterium-tritium fusion. To study He exhaust, an in situ Penning gauge system is being developed at UW-Madison that is optimized for good pressure and high spectroscopic sensitivity. Three different anode geometries have been studied regarding their vacuum electrostatic fields, light output, and ion current. The light output of the two new anode configurations are at least one order of magnitude abovemore » the currently available designs, hence improving the spectroscopic sensitivity at similar total neutral pressure resolution.« less

Development of miniaturized, spectroscopically assisted Penning gauges for fractional helium and hydrogen neutral pressure measurements

DOE PAGES

Flesch, K.; Kremeyer, T.; Schmitz, O.; ...

2016-08-18

Direct measurements of the helium (He) fractional neutral pressure in the neutral gas around fusion devices is challenging because of the small mass difference between the abundant D-2 molecules and the He ash which will be produced by deuterium-tritium fusion. In order to study He exhaust, an in situ Penning gauge system is being developed at UW-Madison that is optimized for good pressure and high spectroscopic sensitivity. There are three different anode geometries that we have studied regarding their vacuum electrostatic fields, light output, and ion current. The light output of the two new anode configurations are at least onemore » order of magnitude above the currently available designs, hence improving the spectroscopic sensitivity at similar total neutral pressure resolution.« less

Progress On Neutrino-Proton Neutral-Current Scattering In MicroBooNE

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pate, Stephen

2017-01-16

The MicroBooNE Experiment at the Fermi National Accelerator Laboratory, an 89-ton active mass liquid argon time projection chamber, affords a unique opportunity to observe low-more » $Q^2$ neutral-current neutrino-proton scattering events. Neutral-current neutrino-proton scattering at $Q^2 < 1$ GeV$^2$ is dominated by the proton's axial form factor, which can be written as a combination of contributions from the up, down, and strange quarks: $$G_A(Q^2) = \\frac{1}{2}[-G_A^u(Q^2)+G_A^d(Q^2)+G_A^s(Q^2)]$$. The contribution from up and down quarks has been established in past charged-current measurements. The contribution from strange quarks at low $Q^2$ remains unmeasured; this is of great interest since the strange quark contribution to the proton spin can be determined from the low-$Q^2$ behavior: $$\\Delta S = G_A^s(Q^2=0)$$. MicroBooNE began operating in the Booster Neutrino Beam in October 2015. I will present the status in observing isolated proton tracks in the MicroBooNE detector as a signature for neutral-current neutrino-proton events. The sensitivity of the MicroBooNE experiment for measuring the strange quark contribution to the proton spin will be discussed.« less

Human papillomavirus vaccination of males: attitudes and perceptions of physicians who vaccinate females.

PubMed

Weiss, Thomas W; Zimet, Gregory D; Rosenthal, Susan L; Brenneman, Susan K; Klein, Jonathan D

2010-07-01

We assessed U.S. physicians' attitudes and perceptions regarding potential human papillomavirus (HPV) vaccination of males. We surveyed a random sample of 2,714 pediatricians and family practitioners identified in administrative claims of a U.S. health plan as HPV vaccinators of females; 595 pediatricians and 499 family practitioners participated. Most physicians would recommend HPV vaccination to males aged 11-12 (63.9%), 13-18 (93.4%), and 19-26 (92.7%) years. Physicians agreed that males should be vaccinated to prevent them from getting genital and anal warts (52.9% strongly and 36.0% somewhat) and to protect females from cervical cancer (75.3% strongly and 20.8% somewhat). Physicians agreed that an HPV vaccine recommendation for males would increase opportunities to discuss sexual health with adolescent male patients (58.7% strongly, 35.3% somewhat). Most did not strongly agree (15.4% strongly, 45.4% somewhat) that parents of adolescent male patients would be interested in HPV vaccination for males, that a gender-neutral HPV vaccine recommendation would increase acceptance by adolescent females and their parents (19.6% strongly, 42.0% somewhat), or that a gender-neutral recommendation would improve current female vaccination rates (10.4% strongly, 26.0% somewhat). Physicians who currently vaccinate females against HPV supported the concept of vaccinating males for its benefits for both sexes. They agreed that a gender-neutral HPV vaccination recommendation would be appropriate with regard to public health and believed that it would increase opportunities for sexual health discussions, but were less sure that such a recommendation would change patient or parental attitudes toward HPV vaccination or improve current HPV vaccination efforts. Copyright (c) 2010 Society for Adolescent Health and Medicine. Published by Elsevier Inc. All rights reserved.

NEXT Long-Duration Test Neutralizer Performance and Erosion Characteristics

NASA Technical Reports Server (NTRS)

Herman, Daniel A.; Soulas, George C.; Patterson, Michael J.

2009-01-01

The NASA's Evolutionary Xenon Thruster (NEXT) program is developing the next-generation ion propulsion system with significant enhancements beyond the state-of-the-art to provide future NASA science missions with enhanced capabilities at a low total development cost. A Long-Duration Test (LDT) was initiated in June 2005, to verify the NEXT propellant throughput capability to a qualification-level of 450 kg, 1.5 times the anticipated throughput requirement of 300 kg per thruster based on mission analyses. As of September 2, 2009, the thruster has accumulated 24,400 hr of operation with extensive durations at the following input powers: 6.9, 4.7, 1.1, and 0.5 kW. The thruster has processed 434 kg of xenon, surpassing the NASA Solar Technology Application Readiness (NSTAR) program thruster propellant throughput demonstrated during the extended life testing of the Deep Space 1 flight spare ion thruster and approaching the NEXT development qualification throughput goal of 450 kg. The NEXT LDT has demonstrated a total impulse of 16.1 10(exp 6zzz0 N s; the highest total impulse ever demonstrated by an ion thruster. A reduction in neutralizer flow margin has been the only appreciable source of thruster performance degradation. The behavior of the neutralizer is not easily predicted due to both erosion and deposition observed in previous wear tests. Spot-to-plume mode transition flow data and in-situ erosion results for the LDT neutralizer are discussed. This loss of flow margin has been addressed through a combination of a design change in the prototype-model neutralizer to increase flow margin at low emission current and to update the NEXT throttle table to ensure adequate flow margin as a function of propellant throughput processed. The new throttle table will be used for future LDT operations. The performance of the NEXT LDT neutralizer is consistent with that observed for long-life hollow cathodes. The neutralizer life-limiting failure modes are progressing as expected and the neutralizer data indicate none of the neutralizer failures are imminent.

A hollow cathode neutralizer for a 30-cm diameter bombardment thruster

NASA Technical Reports Server (NTRS)

Bechtel, R. T.

1973-01-01

Recent improvements in overall thrustor performance have imposed new constraints on neutralizer performance. The use of compensated grid extraction system requires a re-evaluation of neutralizer position. In addition a suitable control logic for the neutralizer has proven difficult. A series of tests were conducted to determine what effect neutralizer cathode geometry has on performance. The parameters investigated included orifice diameter and length, and cathode diameter. Similar tests investigated open and enclosed keeper geometries. Neutralizer position tests with compensated grids suggest positions approximately 10 cm from the accelerator and radially out of the beam envelope should result in satisfactory performance and long life. Finally operation at keeper currents of 1.5 amp has resulted in lower total neutralizer power, the elimination of tip heater power, and suitable closed loop control of the neutralizer vaporizer.

Current profile redistribution driven by neutral beam injection in a reversed-field pinch

DOE Office of Scientific and Technical Information (OSTI.GOV)

Parke, E.; Department of Physics, University of Wisconsin-Madison 1150 University Ave., Madison, Wisconsin 53706; Anderson, J. K.

2016-05-15

Neutral beam injection in reversed-field pinch (RFP) plasmas on the Madison Symmetric Torus [Dexter et al., Fusion Sci. Technol. 19, 131 (1991)] drives current redistribution with increased on-axis current density but negligible net current drive. Internal fluctuations correlated with tearing modes are observed on multiple diagnostics; the behavior of tearing mode correlated structures is consistent with flattening of the safety factor profile. The first application of a parametrized model for island flattening to temperature fluctuations in an RFP allows inferrence of rational surface locations for multiple tearing modes. The m = 1, n = 6 mode is observed to shift inward by 1.1 ± 0.6 cm withmore » neutral beam injection. Tearing mode rational surface measurements provide a strong constraint for equilibrium reconstruction, with an estimated reduction of q{sub 0} by 5% and an increase in on-axis current density of 8% ± 5%. The inferred on-axis current drive is consistent with estimates of fast ion density using TRANSP [Goldston et al., J. Comput. Phys. 43, 61 (1981)].« less

Global modeling of storm-time thermospheric dynamics and electrodynamics

NASA Astrophysics Data System (ADS)

Fuller-Rowell, T. J.; Richmond, A. D.; Maruyama, N.

Understanding the neutral dynamic and electrodynamic response of the upper atmosphere to geomagnetic storms, and quantifying the balance between prompt penetration and disturbance dynamo effects, are two of the significant challenges facing us today. This paper reviews our understanding of the dynamical and electrodynamic response of the upper atmosphere to storms from a modeling perspective. After injection of momentum and energy at high latitude during a geomagnetic storm, the neutral winds begin to respond almost immediately. The high-latitude wind system evolves quickly by the action of ion drag and the injection of kinetic energy; however, Joule dissipation provides the bulk of the energy source to change the dynamics and electrodynamics globally. Impulsive energy injection at high latitudes drives large-scale gravity waves that propagate globally. The waves transmit pressure gradients initiating a change in the global circulation. Numerical simulations of the coupled thermosphere, ionosphere, plasmasphere, and electrodynamic response to storms indicate that although the wind and waves are dynamic, with significant apparent "sloshing" between the hemispheres, the net effect is for an increased equatorward wind. The dynamic changes during a storm provide the conduit for many of the physical processes that ensue in the upper atmosphere. For instance, the increased meridional winds at mid latitudes push plasma parallel to the magnetic field to regions of different composition. The global circulation carries molecular rich air from the lower thermosphere upward and equatorward, changing the ratio of atomic and molecular neutral species, and changing loss rates for the ionosphere. The storm wind system also drives the disturbance dynamo, which through plasma transport modifies the strength and location of the equatorial ionization anomaly peaks. On a global scale, the increased equatorward meridional winds, and the generation of zonal winds at mid latitudes via the Coriolis effects, produce a current system opposing the normal quiet-time Sq current system. At the equator, the storm-time zonal electric fields reduce or reverse the normal upward and downward plasma drift on the dayside and nightside, respectively. In the numerical simulations, on the dayside, the disturbance dynamo appears fairly uniform, whereas at night a stronger local time dependence is apparent with increased upward drift between midnight and dawn. The simulations also indicate the possibility for a rapid dynamo response at the equator, within 2 h of storm onset, before the arrival of the large-scale gravity waves. All these wind-driven processes can result in dramatic ionospheric changes during storms. The disturbance dynamo can combine and interact with the prompt penetration of magnetospheric electric fields to the equator.

Relative contributions of neutral and non-neutral processes to clinal variation in calyx lobe length in the series Sakawanum (Asarum: Aristolochiaceae).

PubMed

Takahashi, Daiki; Teramine, Tsutomu; Sakaguchi, Shota; Setoguchi, Hiroaki

2018-01-25

Clines, the gradual variation in measurable traits along a geographical axis, play a major role in evolution and can contribute to our understanding of the relative roles of selective and neutral process in trait variation. Using genetic and morphological analyses, the relative contributions of neutral and non-neutral processes were explored to infer the evolutionary history of species of the series Sakawanum (genus Asarum), which shows significant clinal variation in calyx lobe length. A total of 27 populations covering the natural geographical distribution of the series Sakawanum were sampled. Six nuclear microsatellite markers were used to investigate genetic structure and genetic diversity. The lengths of calyx lobes of multiple populations were measured to quantify their geographical and taxonomic differentiation. To detect the potential impact of selective pressure, morphological differentiation was compared with genetic differentiation (QCT-FST comparison). Average calyx lobe length of A. minamitanianum was 124.11 mm, while that of A. costatum was 13.80 mm. Though gradually changing along the geographical axis within series, calyx lobe lengths were significantly differentiated among the taxa. Genetic differentiation between taxa was low (FST = 0.099), but a significant geographical structure along the morphological cline was detected. Except for one taxon pair, pairwise QCT values were significantly higher than the neutral genetic measures of FST and G'ST. Divergent selection may have driven the calyx lobe length variation in series Sakawanum taxa, although the underlying mechanism is still not clear. The low genetic differentiation indicates recent divergence and/or gene flows between geographically close taxa. These neutral processes would also affect the clinal variation in calyx lobe lengths. Overall, this study implies the roles of population history and divergent selection in shaping the current cline of a flower trait in the series Sakawanum. © The Author(s) 2017. Published by Oxford University Press on behalf of the Annals of Botany Company. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Enhanced Electroweak Penguin Amplitude in B{yields}VV Decays

DOE Office of Scientific and Technical Information (OSTI.GOV)

Beneke, M.; Rohrer, J.; Yang, D.

2006-04-14

We discuss a novel electromagnetic penguin contribution to the transverse helicity amplitudes in B decays to two vector mesons, which is enhanced by two powers of m{sub B}/{lambda} relative to the standard penguin amplitudes. This leads to unique polarization signatures in penguin-dominated decay modes such as B{yields}{rho}K* similar to polarization effects in the radiative decay B{yields}K*{gamma} and offers new opportunities to probe the magnitude and chirality of flavor-changing neutral current couplings to photons.

Search for single top quark production via contact interactions at LEP2

NASA Astrophysics Data System (ADS)

Abdallah, J.; Abreu, P.; Adam, W.; Adzic, P.; Albrecht, T.; Alemany-Fernandez, R.; Allmendinger, T.; Allport, P. P.; Amaldi, U.; Amapane, N.; Amato, S.; Anashkin, E.; Andreazza, A.; Andringa, S.; Anjos, N.; Antilogus, P.; Apel, W.-D.; Arnoud, Y.; Ask, S.; Asman, B.; Augustin, J. E.; Augustinus, A.; Baillon, P.; Ballestrero, A.; Bambade, P.; Barbier, R.; Bardin, D.; Barker, G. J.; Baroncelli, A.; Battaglia, M.; Baubillier, M.; Becks, K.-H.; Begalli, M.; Behrmann, A.; Ben-Haim, E.; Benekos, N.; Benvenuti, A.; Berat, C.; Berggren, M.; Bertrand, D.; Besancon, M.; Besson, N.; Bloch, D.; Blom, M.; Bluj, M.; Bonesini, M.; Boonekamp, M.; Booth, P. S. L.; Borisov, G.; Botner, O.; Bouquet, B.; Bowcock, T. J. V.; Boyko, I.; Bracko, M.; Brenner, R.; Brodet, E.; Bruckman, P.; Brunet, J. M.; Buschbeck, B.; Buschmann, P.; Calvi, M.; Camporesi, T.; Canale, V.; Carena, F.; Castro, N.; Cavallo, F.; Chapkin, M.; Charpentier, Ph.; Checchia, P.; Chierici, R.; Chliapnikov, P.; Chudoba, J.; Chung, S. U.; Cieslik, K.; Collins, P.; Contri, R.; Cosme, G.; Cossutti, F.; Costa, M. J.; Crennell, D.; Cuevas, J.; D'Hondt, J.; da Silva, T.; da Silva, W.; Della Ricca, G.; de Angelis, A.; de Boer, W.; de Clercq, C.; de Lotto, B.; de Maria, N.; de Min, A.; de Paula, L.; di Ciaccio, L.; di Simone, A.; Doroba, K.; Drees, J.; Eigen, G.; Ekelof, T.; Ellert, M.; Elsing, M.; Espirito Santo, M. C.; Fanourakis, G.; Fassouliotis, D.; Feindt, M.; Fernandez, J.; Ferrer, A.; Ferro, F.; Flagmeyer, U.; Foeth, H.; Fokitis, E.; Fulda-Quenzer, F.; Fuster, J.; Gandelman, M.; Garcia, C.; Gavillet, Ph.; Gazis, E.; Gokieli, R.; Golob, B.; Gomez-Ceballos, G.; Goncalves, P.; Graziani, E.; Grosdidier, G.; Grzelak, K.; Guy, J.; Haag, C.; Hallgren, A.; Hamacher, K.; Hamilton, K.; Haug, S.; Hauler, F.; Hedberg, V.; Hennecke, M.; Hoffman, J.; Holmgren, S.-O.; Holt, P. J.; Houlden, M. A.; Jackson, J. N.; Jarlskog, G.; Jarry, P.; Jeans, D.; Johansson, E. K.; Jonsson, P.; Joram, C.; Jungermann, L.; Kapusta, F.; Katsanevas, S.; Katsoufis, E.; Kernel, G.; Kersevan, B. P.; Kerzel, U.; King, B. T.; Kjaer, N. J.; Kluit, P.; Kokkinias, P.; Kourkoumelis, C.; Kouznetsov, O.; Krumstein, Z.; Kucharczyk, M.; Lamsa, J.; Leder, G.; Ledroit, F.; Leinonen, L.; Leitner, R.; Lemonne, J.; Lepeltier, V.; Lesiak, T.; Liebig, W.; Liko, D.; Lipniacka, A.; Lopes, J. H.; Lopez, J. M.; Loukas, D.; Lutz, P.; Lyons, L.; MacNaughton, J.; Malek, A.; Maltezos, S.; Mandl, F.; Marco, J.; Marco, R.; Marechal, B.; Margoni, M.; Marin, J.-C.; Mariotti, C.; Markou, A.; Martinez-Rivero, C.; Masik, J.; Mastroyiannopoulos, N.; Matorras, F.; Matteuzzi, C.; Mazzucato, F.; Mazzucato, M.; Mc Nulty, R.; Meroni, C.; Migliore, E.; Mitaroff, W.; Mjoernmark, U.; Moa, T.; Moch, M.; Moenig, K.; Monge, R.; Montenegro, J.; Moraes, D.; Moreno, S.; Morettini, P.; Mueller, U.; Muenich, K.; Mulders, M.; Mundim, L.; Murray, W.; Muryn, B.; Myatt, G.; Myklebust, T.; Nassiakou, M.; Navarria, F.; Nawrocki, K.; Nemecek, S.; Nicolaidou, R.; Nikolenko, M.; Oblakowska-Mucha, A.; Obraztsov, V.; Oliveira, O.; Olshevski, A.; Onofre, A.; Orava, R.; Osterberg, K.; Ouraou, A.; Oyanguren, A.; Paganoni, M.; Paiano, S.; Palacios, J. P.; Palka, H.; Papadopoulou, Th. D.; Pape, L.; Parkes, C.; Parodi, F.; Parzefall, U.; Passeri, A.; Passon, O.; Peralta, L.; Perepelitsa, V.; Perrotta, A.; Petrolini, A.; Piedra, J.; Pieri, L.; Pierre, F.; Pimenta, M.; Piotto, E.; Podobnik, T.; Poireau, V.; Pol, M. E.; Polok, G.; Pozdniakov, V.; Pukhaeva, N.; Pullia, A.; Radojicic, D.; Rebecchi, P.; Rehn, J.; Reid, D.; Reinhardt, R.; Renton, P.; Richard, F.; Ridky, J.; Rivero, M.; Rodriguez, D.; Romero, A.; Ronchese, P.; Roudeau, P.; Rovelli, T.; Ruhlmann-Kleider, V.; Ryabtchikov, D.; Sadovsky, A.; Salmi, L.; Salt, J.; Sander, C.; Savoy-Navarro, A.; Schwickerath, U.; Sekulin, R.; Siebel, M.; Sisakian, A.; Smadja, G.; Smirnova, O.; Sokolov, A.; Sopczak, A.; Sosnowski, R.; Spassov, T.; Stanitzki, M.; Stocchi, A.; Strauss, J.; Stugu, B.; Szczekowski, M.; Szeptycka, M.; Szumlak, T.; Tabarelli, T.; Tegenfeldt, F.; Timmermans, J.; Tkatchev, L.; Tobin, M.; Todorovova, S.; Tome, B.; Tonazzo, A.; Tortosa, P.; Travnicek, P.; Treille, D.; Tristram, G.; Trochimczuk, M.; Troncon, C.; Turluer, M.-L.; Tyapkin, I. A.; Tyapkin, P.; Tzamarias, S.; Uvarov, V.; Valenti, G.; van Dam, P.; van Eldik, J.; van Remortel, N.; van Vulpen, I.; Vegni, G.; Veloso, F.; Venus, W.; Verdier, P.; Verzi, V.; Vilanova, D.; Vitale, L.; Vrba, V.; Wahlen, H.; Washbrook, A. J.; Weiser, C.; Wicke, D.; Wickens, J.; Wilkinson, G.; Winter, M.; Witek, M.; Yushchenko, O.; Zalewska, A.; Zalewski, P.; Zavrtanik, D.; Zhuravlov, V.; Zimin, N. I.; Zintchenko, A.; Zupan, M.

2011-02-01

Single top quark production via four-fermion contact interactions associated to flavour-changing neutral currents was searched for in data taken by the DELPHI detector at LEP2. The data were accumulated at centre-of-mass energies ranging from 189 to 209 GeV, with an integrated luminosity of 598.1 pb-1. No evidence for a signal was found. Limits on the energy scale Λ, were set for scalar-, vector- and tensor-like coupling scenarios.

Escape from washing out of baryon number in a two-zero-texture general Zee model compatible with the large mixing angle MSW solution

NASA Astrophysics Data System (ADS)

Hasegawa, K.; Lim, C. S.; Ogure, K.

2003-09-01

We propose a two-zero-texture general Zee model, compatible with the large mixing angle Mikheyev-Smirnov-Wolfenstein solution. The washing out of the baryon number does not occur in this model for an adequate parameter range. We check the consistency of a model with the constraints coming from flavor changing neutral current processes, the recent cosmic microwave background observation, and the Z-burst scenario.

Antigenic properties of the human immunodeficiency virus envelope glycoprotein gp120 on virions bound to target cells.

PubMed

Mengistu, Meron; Ray, Krishanu; Lewis, George K; DeVico, Anthony L

2015-03-01

The HIV-1 envelope glycoprotein, gp120, undergoes multiple molecular interactions and structural rearrangements during the course of host cell attachment and viral entry, which are being increasingly defined at the atomic level using isolated proteins. In comparison, antigenic markers of these dynamic changes are essentially unknown for single HIV-1 particles bound to target cells. Such markers should indicate how neutralizing and/or non-neutralizing antibodies might interdict infection by either blocking infection or sensitizing host cells for elimination by Fc-mediated effector function. Here we address this deficit by imaging fluorescently labeled CCR5-tropic HIV-1 pseudoviruses using confocal and superresolution microscopy to track the exposure of neutralizing and non-neutralizing epitopes as they appear on single HIV-1 particles bound to target cells. Epitope exposure was followed under conditions permissive or non-permissive for viral entry to delimit changes associated with virion binding from those associated with post-attachment events. We find that a previously unexpected array of gp120 epitopes is exposed rapidly upon target cell binding. This array comprises both neutralizing and non-neutralizing epitopes, the latter being hidden on free virions yet capable of serving as potent targets for Fc-mediated effector function. Under non-permissive conditions for viral entry, both neutralizing and non-neutralizing epitope exposures were relatively static over time for the majority of bound virions. Under entry-permissive conditions, epitope exposure patterns changed over time on subsets of virions that exhibited concurrent variations in virion contents. These studies reveal that bound virions are distinguished by a broad array of both neutralizing and non-neutralizing gp120 epitopes that potentially sensitize a freshly engaged target cell for destruction by Fc-mediated effector function and/or for direct neutralization at a post-binding step. The elucidation of these epitope exposure patterns during viral entry will help clarify antibody-mediated inhibition of HIV-1 as it is measured in vitro and in vivo.

Graded Neuronal Modulations Related to Visual Spatial Attention.

PubMed

Mayo, J Patrick; Maunsell, John H R

2016-05-11

Studies of visual attention in monkeys typically measure neuronal activity when the stimulus event to be detected occurs at a cued location versus when it occurs at an uncued location. But this approach does not address how neuronal activity changes relative to conditions where attention is unconstrained by cueing. Human psychophysical studies have used neutral cueing conditions and found that neutrally cued behavioral performance is generally intermediate to that of cued and uncued conditions (Posner et al., 1978; Mangun and Hillyard, 1990; Montagna et al., 2009). To determine whether the neuronal correlates of visual attention during neutral cueing are similarly intermediate, we trained macaque monkeys to detect changes in stimulus orientation that were more likely to occur at one location (cued) than another (uncued), or were equally likely to occur at either stimulus location (neutral). Consistent with human studies, performance was best when the location was cued, intermediate when both locations were neutrally cued, and worst when the location was uncued. Neuronal modulations in visual area V4 were also graded as a function of cue validity and behavioral performance. By recording from both hemispheres simultaneously, we investigated the possibility of switching attention between stimulus locations during neutral cueing. The results failed to support a unitary "spotlight" of attention. Overall, our findings indicate that attention-related changes in V4 are graded to accommodate task demands. Studies of the neuronal correlates of attention in monkeys typically use visual cues to manipulate where attention is focused ("cued" vs "uncued"). Human psychophysical studies often also include neutrally cued trials to study how attention naturally varies between points of interest. But the neuronal correlates of this neutral condition are unclear. We measured behavioral performance and neuronal activity in cued, uncued, and neutrally cued blocks of trials. Behavioral performance and neuronal responses during neutral cueing were intermediate to those of the cued and uncued conditions. We found no signatures of a single mechanism of attention that switches between stimulus locations. Thus, attention-related changes in neuronal activity are largely hemisphere-specific and graded according to task demands. Copyright © 2016 the authors 0270-6474/16/365353-09$15.00/0.

Graded Neuronal Modulations Related to Visual Spatial Attention

PubMed Central

Maunsell, John H. R.

2016-01-01

Studies of visual attention in monkeys typically measure neuronal activity when the stimulus event to be detected occurs at a cued location versus when it occurs at an uncued location. But this approach does not address how neuronal activity changes relative to conditions where attention is unconstrained by cueing. Human psychophysical studies have used neutral cueing conditions and found that neutrally cued behavioral performance is generally intermediate to that of cued and uncued conditions (Posner et al., 1978; Mangun and Hillyard, 1990; Montagna et al., 2009). To determine whether the neuronal correlates of visual attention during neutral cueing are similarly intermediate, we trained macaque monkeys to detect changes in stimulus orientation that were more likely to occur at one location (cued) than another (uncued), or were equally likely to occur at either stimulus location (neutral). Consistent with human studies, performance was best when the location was cued, intermediate when both locations were neutrally cued, and worst when the location was uncued. Neuronal modulations in visual area V4 were also graded as a function of cue validity and behavioral performance. By recording from both hemispheres simultaneously, we investigated the possibility of switching attention between stimulus locations during neutral cueing. The results failed to support a unitary “spotlight” of attention. Overall, our findings indicate that attention-related changes in V4 are graded to accommodate task demands. SIGNIFICANCE STATEMENT Studies of the neuronal correlates of attention in monkeys typically use visual cues to manipulate where attention is focused (“cued” vs “uncued”). Human psychophysical studies often also include neutrally cued trials to study how attention naturally varies between points of interest. But the neuronal correlates of this neutral condition are unclear. We measured behavioral performance and neuronal activity in cued, uncued, and neutrally cued blocks of trials. Behavioral performance and neuronal responses during neutral cueing were intermediate to those of the cued and uncued conditions. We found no signatures of a single mechanism of attention that switches between stimulus locations. Thus, attention-related changes in neuronal activity are largely hemisphere-specific and graded according to task demands. PMID:27170131

Neutralization of Plutonium and Enriched Uranium Solutions Containing Gadolinium as a Neutron Poison

DOE Office of Scientific and Technical Information (OSTI.GOV)

BRONIKOWSKI, MG.

2004-04-01

Materials currently being dissolved in the HB-Line Facility will result in an accumulated solution containing an estimated uranium:plutonium (U:Pu) ratio of 4.3:1 and an 235U enrichment estimated at 30 per cent The U:Pu ratio and the enrichment are outside the evaluated concentration range for disposition to high level waste (HLW) using gadolinium (Gd) as a neutron poison. To confirm that the solution generated during the current HB-Line dissolving campaign can be poisoned with Gd, neutralized and discarded to the Savannah River Site (SRS) high level waste (HLW) system without undue nuclear safety concerns the caustic precipitation of surrogate solutions wasmore » examined. Experiments were performed with a U/Pu/Gd solution representative of the HB-Line estimated concentration ratio and also a U/Gd solution. Depleted U was used in the experiments as the enrichment of the U will not affect the chemical behavior during neutralization, but will affect the amount of Gd added to the solution. Settling behavior of the neutralized solutions was found to be comparable to previous studies. The neutralized solutions mixed easily and had expected densities of typical neutralized waste. The neutralized solids were found to be homogeneous and less than 20 microns in size. Partially neutralized solids were more amorphous than the fully neutralized solids. Based on the results of these experiments, Gd was found to be a viable poison for neutralizing a U/Pu/Gd solution with a U:Pu mass ratio of 4.3:1 thus extending the U:Pu mass ratio from the previously investigated 0-3:1 to 4.3:1. However, further work is needed to allow higher U concentrations or U:Pu ratios greater than investigated in this work.« less

Listening to a conversation with aggressive content expands the interpersonal space

PubMed Central

Vagnoni, Eleonora; Lewis, Jessica; Tajadura-Jiménez, Ana

2018-01-01

The distance individuals maintain between themselves and others can be defined as ‘interpersonal space’. This distance can be modulated both by situational factors and individual characteristics. Here we investigated the influence that the interpretation of other people interaction, in which one is not directly involved, may have on a person’s interpersonal space. In the current study we measured, for the first time, whether the size of interpersonal space changes after listening to other people conversations with neutral or aggressive content. The results showed that the interpersonal space expands after listening to a conversation with aggressive content relative to a conversation with a neutral content. This finding suggests that participants tend to distance themselves from an aggressive confrontation even if they are not involved in it. These results are in line with the view of the interpersonal space as a safety zone surrounding one’s body. PMID:29590110

The role of top in heavy flavor physics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hewett, J.L.

1997-01-01

The implications of the massive top quark on heavy flavor transitions are explored. We review the generation of quark masses and mixings and the determination techniques, and present the status of the elements of the weak mixing matrix. Purely leptonic decays of heavy mesons are briefly summarized. We present a general introduction to flavor changing neutral currents and an extensive summary of radiative and other rare decay modes. The physics of neutral meson mixing is reviewed and applied to each meson system. We describe the phenomenology of CP violation and how it may be measured in meson decays. Standard Modelmore » predictions are given in each case and the effects of physics beyond the Standard Model are also discussed. Throughout, we contrast these transitions in the K and B meson systems to those in the D meson and top-quark sectors.« less

CHP -- A revolution in the making

DOE Office of Scientific and Technical Information (OSTI.GOV)

Green, D.

1999-07-01

Liberalization, globalization, and particularly climate change are changing energy thinking. In the future, climate change will be tackled by improved energy efficiency and carbon neutral sources of energy, but much more could be done today by the more widespread use of CHP. CHP has made reasonably good progress in the UK and Europe, due to energy industry liberalization and the widespread availability of gas. But the pursuit of sustainability objectives requires government intervention into liberalized markets. While the current UK Government is a strong supporter of CHP, major opportunities to develop CHP were missed in favor of less efficient CCGTmore » power stations over the last decade. The two critical policy issues in the UK now are the proposed tax on the business use of energy and the current reform of electricity trading arrangements. Both could impact favorably on the development of CHP. The UK CHP Association, COGEN Europe and the International Cogeneration Alliance continue to press the case for CHP.« less

Is laughter a better vocal change detector than a growl?

PubMed

Pinheiro, Ana P; Barros, Carla; Vasconcelos, Margarida; Obermeier, Christian; Kotz, Sonja A

2017-07-01

The capacity to predict what should happen next and to minimize any discrepancy between an expected and an actual sensory input (prediction error) is a central aspect of perception. Particularly in vocal communication, the effective prediction of an auditory input that informs the listener about the emotionality of a speaker is critical. What is currently unknown is how the perceived valence of an emotional vocalization affects the capacity to predict and detect a change in the auditory input. This question was probed in a combined event-related potential (ERP) and time-frequency analysis approach. Specifically, we examined the brain response to standards (Repetition Positivity) and to deviants (Mismatch Negativity - MMN), as well as the anticipatory response to the vocal sounds (pre-stimulus beta oscillatory power). Short neutral, happy (laughter), and angry (growls) vocalizations were presented both as standard and deviant stimuli in a passive oddball listening task while participants watched a silent movie and were instructed to ignore the vocalizations. MMN amplitude was increased for happy compared to neutral and angry vocalizations. The Repetition Positivity was enhanced for happy standard vocalizations. Induced pre-stimulus upper beta power was increased for happy vocalizations, and predicted the modulation of the standard Repetition Positivity. These findings indicate enhanced sensory prediction for positive vocalizations such as laughter. Together, the results suggest that positive vocalizations are more effective predictors in social communication than angry and neutral ones, possibly due to their high social significance. Copyright © 2017 Elsevier Ltd. All rights reserved.

Daboia russellii and Naja kaouthia venom neutralization by lupeol acetate isolated from the root extract of Indian sarsaparilla Hemidesmus indicus R.Br.

PubMed

Chatterjee, Ipshita; Chakravarty, A K; Gomes, A

2006-06-15

The present study reports the isolation and purification of lupeol acetate from the methanolic root extract of Indian medicinal plant Hemidesmus indicus (L.) R.Br. (family: Asclepiadaceae) which could neutralize venom induced action of Daboia russellii and Naja kaouthia on experimental animals. Lupeol acetate could significantly neutralize lethality, haemorrhage, defibrinogenation, edema, PLA(2) activity induced by Daboia russellii venom. It also neutralized Naja kaouthia venom induced lethality, cardiotoxicity, neurotoxicity and respiratory changes in experimental animals. Lupeol acetate potentiated the protection by snake venom antiserum action against Daboia russellii venom induced lethality in male albino mice. Venom induced changes in lipid peroxidation and super oxide dismutase activity was antagonized by lupeol acetate. Snake venom neutralization by lupeol acetate and its possible mechanism of action has been discussed.

Role of a Helix B Lysine Residue in the Photoactive Site in Channelrhodopsins

PubMed Central

Li, Hai; Govorunova, Elena G.; Sineshchekov, Oleg A.; Spudich, John L.

2014-01-01

In most studied microbial rhodopsins two conserved carboxylic acid residues (the homologs of Asp-85 and Asp-212 in bacteriorhodopsin) and an arginine residue (the homolog of Arg-82) form a complex counterion to the protonated retinylidene Schiff base, and neutralization of the negatively charged carboxylates causes red shifts of the absorption maximum. In contrast, the corresponding neutralizing mutations in some relatively low-efficiency channelrhodopsins (ChRs) result in blue shifts. These ChRs do not contain a lysine residue in the second helix, conserved in higher efficiency ChRs (Lys-132 in the crystallized ChR chimera). By action spectroscopy of photoinduced channel currents in HEK293 cells and absorption spectroscopy of detergent-purified pigments, we found that in tested ChRs the Lys-132 homolog controls the direction of spectral shifts in the mutants of the photoactive site carboxylic acid residues. Analysis of double mutants shows that red spectral shifts occur when this Lys is present, whether naturally or by mutagenesis, and blue shifts occur when it is replaced with a neutral residue. A neutralizing mutation of the Lys-132 homolog alone caused a red spectral shift in high-efficiency ChRs, whereas its introduction into low-efficiency ChR1 from Chlamydomonas augustae (CaChR1) caused a blue shift. Taking into account that the effective charge of the carboxylic acid residues is a key factor in microbial rhodopsin spectral tuning, these findings suggest that the Lys-132 homolog modulates their pKa values. On the other hand, mutation of the Arg-82 homolog that fulfills this role in bacteriorhodopsin caused minimal spectral changes in the tested ChRs. Titration revealed that the pKa of the Asp-85 homolog in CaChR1 lies in the alkaline region unlike in most studied microbial rhodopsins, but is substantially decreased by introduction of a Lys-132 homolog or neutralizing mutation of the Asp-212 homolog. In the three ChRs tested the Lys-132 homolog also alters channel current kinetics. PMID:24739160

Ultrasound analysis of the vertebral artery during non-thrust cervical translatoric spinal manipulation.

PubMed

Creighton, Doug; Kondratek, Melodie; Krauss, John; Huijbregts, Peter; Qu, Harvey

2011-05-01

Cervical translatoric spinal manipulation (TSM) techniques have been suggested as a safer alternative to cervical thrust rotatory techniques. The objective of this study was to determine the effect of three C5-C6 non-thrust TSM techniques on vertebral artery (VA) lumen diameter (LD) and two blood flow velocity parameters. The two-tailed research hypothesis was that the TSM techniques would result in a significant change (increase or decrease) in blood flow velocity and arterial LD at the C5-C6 intertransverse portion of the VA. In a sample of 30 subjects representative of a clinical population, color-coded duplex Doppler diagnostic ultrasound imaging was used to collect data on LD, peak systolic velocity (PSV), and end diastolic velocity with the cervical spine positioned in neutral and in three different manipulation positions. Pair-wise mean differences between measurements at baseline (neutral position) and in all three manipulation positions were analyzed using two-tailed paired t-tests with alpha set at 0·05. Of the 18 paired comparisons, there were four statistically significant differences between measurements in the neutral position and a manipulation position, three concerning LD and one PSV. The three significant differences in LD ranged from 4·6 to 3·2% and were not associated with changes in blood flow velocity. The one significant change in PSV was only 6·6 cm/s. A value that still greatly exceeded the end diastolic velocity. No subject experienced symptoms associated with VA compromise. This study has provided evidence for the safety of the three lower cervical non-thrust TSM techniques on the current population studied. Further study is required on thrust versus non-thrust TSM techniques and on levels other than C5-C6.

The earth's ring current - Present situation and future thrusts

NASA Technical Reports Server (NTRS)

Williams, D. J.

1987-01-01

Particle distributions, currents, and the ring current situation prior to the August 1984 launch of the AMPTE Charge Composition Explorer (CCE) are discussed. CCE results which demonstrate the capability of these new measurements to pursue questions of ring current sources, energization, and transport are presented. Consideration is given to various ring current generation mechanisms which have been discussed in the literature, and a two-step generation process which to a certain extent unifies the previous mechanisms is presented. The first in-situ global observations of ring current decay as obtained through the detection of energetic neutral atoms generated by charge exchange interactions between the ring current and hydrogen geocorona are discussed, as well as the possibility of using the detection of energetic neutral atoms to obtain global images of the earth's ring current.

THE ORIGIN OF NET ELECTRIC CURRENTS IN SOLAR ACTIVE REGIONS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dalmasse, K.; Aulanier, G.; Démoulin, P.

There is a recurring question in solar physics regarding whether or not electric currents are neutralized in active regions (ARs). This question was recently revisited using three-dimensional (3D) magnetohydrodynamic (MHD) numerical simulations of magnetic flux emergence into the solar atmosphere. Such simulations showed that flux emergence can generate a substantial net current in ARs. Other sources of AR currents are photospheric horizontal flows. Our aim is to determine the conditions for the occurrence of net versus neutralized currents with this second mechanism. Using 3D MHD simulations, we systematically impose line-tied, quasi-static, photospheric twisting and shearing motions to a bipolar potentialmore » magnetic field. We find that such flows: (1) produce both direct and return currents, (2) induce very weak compression currents—not observed in 2.5D—in the ambient field present in the close vicinity of the current-carrying field, and (3) can generate force-free magnetic fields with a net current. We demonstrate that neutralized currents are in general produced only in the absence of magnetic shear at the photospheric polarity inversion line—a special condition that is rarely observed. We conclude that  photospheric flows, as magnetic flux emergence, can build up net currents in the solar atmosphere, in agreement with recent observations. These results thus provide support for eruption models based on pre-eruption magnetic fields that possess a net coronal current.« less

Neutralizer Characterization of a NEXT Multi-Thruster Array With Electrostatic Probes

NASA Technical Reports Server (NTRS)

Foster, John E.; Patterson, Michael; Pencil, Eric; McEwen, Heather; Diaz, Esther

2006-01-01

Neutralizers in a multi-thruster array configuration were characterized using conventional diagnostics such as peak-to-peak keeper oscillation amplitude as well as unconventional methods which featured the application of electrostatic probes. The response of the array local plasma environment to neutralizer flow rate changes were documented using Langmuir probes and retarding potential analyzers. Such characterization is necessary for system efficiency and stability optimization. Because the local plasma environment was measured in conjunction with the neutralizer characterization, particle fluxes at the array and thus array lifetime impacts associated with neutralizer operating mode could also be investigated. Neutralizer operating condition was documented for a number of multithruster array configurations ranging from three-engines, three-neutralizers to a single engine, one-neutralizer all as a function of neutralizer flow rate.

Antibodies Elicited by Multiple Envelope Glycoprotein Immunogens in Primates Neutralize Primary Human Immunodeficiency Viruses (HIV-1) Sensitized by CD4-Mimetic Compounds

PubMed Central

Madani, Navid; Princiotto, Amy M.; Easterhoff, David; Bradley, Todd; Luo, Kan; Williams, Wilton B.; Liao, Hua-Xin; Moody, M. Anthony; Phad, Ganesh E.; Vázquez Bernat, Néstor; Melillo, Bruno; Santra, Sampa; Smith, Amos B.; Karlsson Hedestam, Gunilla B.; Haynes, Barton

2016-01-01

ABSTRACT The human immunodeficiency virus (HIV-1) envelope glycoproteins (Env) mediate virus entry through a series of complex conformational changes triggered by binding to the receptors CD4 and CCR5/CXCR4. Broadly neutralizing antibodies that recognize conserved Env epitopes are thought to be an important component of a protective immune response. However, to date, HIV-1 Env immunogens that elicit broadly neutralizing antibodies have not been identified, creating hurdles for vaccine development. Small-molecule CD4-mimetic compounds engage the CD4-binding pocket on the gp120 exterior Env and induce Env conformations that are highly sensitive to neutralization by antibodies, including antibodies directed against the conserved Env region that interacts with CCR5/CXCR4. Here, we show that CD4-mimetic compounds sensitize primary HIV-1 to neutralization by antibodies that can be elicited in monkeys and humans within 6 months by several Env vaccine candidates, including gp120 monomers. Monoclonal antibodies directed against the gp120 V2 and V3 variable regions were isolated from the immunized monkeys and humans; these monoclonal antibodies neutralized a primary HIV-1 only when the virus was sensitized by a CD4-mimetic compound. Thus, in addition to their direct antiviral effect, CD4-mimetic compounds dramatically enhance the HIV-1-neutralizing activity of antibodies that can be elicited with currently available immunogens. Used as components of microbicides, the CD4-mimetic compounds might increase the protective efficacy of HIV-1 vaccines. IMPORTANCE Preventing HIV-1 transmission is a high priority for global health. Eliciting antibodies that can neutralize transmitted strains of HIV-1 is difficult, creating problems for the development of an effective vaccine. We found that small-molecule CD4-mimetic compounds sensitize HIV-1 to antibodies that can be elicited in vaccinated humans and monkeys. These results suggest an approach to prevent HIV-1 sexual transmission in which a virus-sensitizing microbicide is combined with a vaccine. PMID:26962221

The nearly neutral and selection theories of molecular evolution under the fisher geometrical framework: substitution rate, population size, and complexity.

PubMed

Razeto-Barry, Pablo; Díaz, Javier; Vásquez, Rodrigo A

2012-06-01

The general theories of molecular evolution depend on relatively arbitrary assumptions about the relative distribution and rate of advantageous, deleterious, neutral, and nearly neutral mutations. The Fisher geometrical model (FGM) has been used to make distributions of mutations biologically interpretable. We explored an FGM-based molecular model to represent molecular evolutionary processes typically studied by nearly neutral and selection models, but in which distributions and relative rates of mutations with different selection coefficients are a consequence of biologically interpretable parameters, such as the average size of the phenotypic effect of mutations and the number of traits (complexity) of organisms. A variant of the FGM-based model that we called the static regime (SR) represents evolution as a nearly neutral process in which substitution rates are determined by a dynamic substitution process in which the population's phenotype remains around a suboptimum equilibrium fitness produced by a balance between slightly deleterious and slightly advantageous compensatory substitutions. As in previous nearly neutral models, the SR predicts a negative relationship between molecular evolutionary rate and population size; however, SR does not have the unrealistic properties of previous nearly neutral models such as the narrow window of selection strengths in which they work. In addition, the SR suggests that compensatory mutations cannot explain the high rate of fixations driven by positive selection currently found in DNA sequences, contrary to what has been previously suggested. We also developed a generalization of SR in which the optimum phenotype can change stochastically due to environmental or physiological shifts, which we called the variable regime (VR). VR models evolution as an interplay between adaptive processes and nearly neutral steady-state processes. When strong environmental fluctuations are incorporated, the process becomes a selection model in which evolutionary rate does not depend on population size, but is critically dependent on the complexity of organisms and mutation size. For SR as well as VR we found that key parameters of molecular evolution are linked by biological factors, and we showed that they cannot be fixed independently by arbitrary criteria, as has usually been assumed in previous molecular evolutionary models.

The Nearly Neutral and Selection Theories of Molecular Evolution Under the Fisher Geometrical Framework: Substitution Rate, Population Size, and Complexity

PubMed Central

Razeto-Barry, Pablo; Díaz, Javier; Vásquez, Rodrigo A.

2012-01-01

The general theories of molecular evolution depend on relatively arbitrary assumptions about the relative distribution and rate of advantageous, deleterious, neutral, and nearly neutral mutations. The Fisher geometrical model (FGM) has been used to make distributions of mutations biologically interpretable. We explored an FGM-based molecular model to represent molecular evolutionary processes typically studied by nearly neutral and selection models, but in which distributions and relative rates of mutations with different selection coefficients are a consequence of biologically interpretable parameters, such as the average size of the phenotypic effect of mutations and the number of traits (complexity) of organisms. A variant of the FGM-based model that we called the static regime (SR) represents evolution as a nearly neutral process in which substitution rates are determined by a dynamic substitution process in which the population’s phenotype remains around a suboptimum equilibrium fitness produced by a balance between slightly deleterious and slightly advantageous compensatory substitutions. As in previous nearly neutral models, the SR predicts a negative relationship between molecular evolutionary rate and population size; however, SR does not have the unrealistic properties of previous nearly neutral models such as the narrow window of selection strengths in which they work. In addition, the SR suggests that compensatory mutations cannot explain the high rate of fixations driven by positive selection currently found in DNA sequences, contrary to what has been previously suggested. We also developed a generalization of SR in which the optimum phenotype can change stochastically due to environmental or physiological shifts, which we called the variable regime (VR). VR models evolution as an interplay between adaptive processes and nearly neutral steady-state processes. When strong environmental fluctuations are incorporated, the process becomes a selection model in which evolutionary rate does not depend on population size, but is critically dependent on the complexity of organisms and mutation size. For SR as well as VR we found that key parameters of molecular evolution are linked by biological factors, and we showed that they cannot be fixed independently by arbitrary criteria, as has usually been assumed in previous molecular evolutionary models. PMID:22426879

Inclusive neutrino scattering off the deuteron at low energies in chiral effective field theory

DOE PAGES

Baroni, A.; Schiavilla, R.

2017-07-19

Cross sections for inclusive neutrino scattering off deuteron induced by neutral and charge-changing weak currents are calculated from threshold up to 150 MeV energies in a chiral effective field theory including high orders in the power counting. The contributions beyond leading order (LO) in the weak current are found to be small, and increase the cross sections obtained with the LO transition operators by a couple of percent over the whole energy range (0--150) MeV. Furthermore, the cutoff dependence is negligible, and the predicted cross sections are within ~2% of, albeit consistently larger than, corresponding predictions obtained in conventional meson-exchangemore » frameworks.« less

Constraints and implications on Higgs FCNC couplings from precision measurement of Bs→μ+μ- decay

NASA Astrophysics Data System (ADS)

Chiang, Cheng-Wei; He, Xiao-Gang; Ye, Fang; Yuan, Xing-Bo

2017-08-01

We study constraints and implications of the recent LHCb measurement of B (Bs→μ+μ-) for tree-level Higgs-mediated flavor-changing neutral current (FCNC) interactions. Combined with experimental data on the Bs mass difference Δ ms and the h →μ τ and h →τ+τ- decay branching ratios from the LHC, we find that the Higgs FCNC couplings are severely constrained. The allowed regions for Bs→μ τ , τ τ and h →s b decays are obtained. Current data allow large C P violation in the h →τ+τ- decay. Consequences of the Cheng-Sher ansatz for the Higgs-Yukawa couplings are discussed in some detail.

ASYMMETRIC MAGNETIC RECONNECTION IN WEAKLY IONIZED CHROMOSPHERIC PLASMAS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Murphy, Nicholas A.; Lukin, Vyacheslav S., E-mail: namurphy@cfa.harvard.edu

2015-06-01

Realistic models of magnetic reconnection in the solar chromosphere must take into account that the plasma is partially ionized and that plasma conditions within any two magnetic flux bundles undergoing reconnection may not be the same. Asymmetric reconnection in the chromosphere may occur when newly emerged flux interacts with pre-existing, overlying flux. We present 2.5D simulations of asymmetric reconnection in weakly ionized, reacting plasmas where the magnetic field strengths, ion and neutral densities, and temperatures are different in each upstream region. The plasma and neutral components are evolved separately to allow non-equilibrium ionization. As in previous simulations of chromospheric reconnection,more » the current sheet thins to the scale of the neutral–ion mean free path and the ion and neutral outflows are strongly coupled. However, the ion and neutral inflows are asymmetrically decoupled. In cases with magnetic asymmetry, a net flow of neutrals through the current sheet from the weak-field (high-density) upstream region into the strong-field upstream region results from a neutral pressure gradient. Consequently, neutrals dragged along with the outflow are more likely to originate from the weak-field region. The Hall effect leads to the development of a characteristic quadrupole magnetic field modified by asymmetry, but the X-point geometry expected during Hall reconnection does not occur. All simulations show the development of plasmoids after an initial laminar phase.« less

Internal transport barrier triggered by non-linear lower hybrid wave deposition under condition of beam-driven toroidal rotation

NASA Astrophysics Data System (ADS)

Gao, Q. D.; Budny, R. V.

2015-03-01

By using gyro-Landau fluid transport model (GLF23), time-dependent integrated modeling is carried out using TRANSP to explore the dynamic process of internal transport barrier (ITB) formation in the neutral beam heating discharges. When the current profile is controlled by LHCD (lower hybrid current drive), with appropriate neutral beam injection, the nonlinear interplay between the transport determined gradients in the plasma temperature (Ti,e) and toroidal velocity (Vϕ) and the E×B flow shear (including q-profile) produces transport bifurcations, generating spontaneously a stepwise growing ITB. In the discharge, the constraints imposed by the wave propagation condition causes interplay of the LH driven current distribution with the plasma configuration modification, which constitutes non-linearity in the LH wave deposition. The non-linear effects cause bifurcation in LHCD, generating two distinct quasi-stationary reversed magnetic shear configurations. The change of current profile during the transition period between the two quasi-stationary states results in increase of the E×B shearing flow arising from toroidal rotation. The turbulence transport suppression by sheared E×B flow during the ITB development is analysed, and the temporal evolution of some parameters characterized the plasma confinement is examined. Ample evidence shows that onset of the ITB development is correlated with the enhancement of E×B shearing rate caused by the bifurcation in LHCD. It is suggested that the ITB triggering is associated with the non-linear effects of the LH power deposition.

Anomalous diffusion in neutral evolution of model proteins.

PubMed

Nelson, Erik D; Grishin, Nick V

2015-06-01

Protein evolution is frequently explored using minimalist polymer models, however, little attention has been given to the problem of structural drift, or diffusion. Here, we study neutral evolution of small protein motifs using an off-lattice heteropolymer model in which individual monomers interact as low-resolution amino acids. In contrast to most earlier models, both the length and folded structure of the polymers are permitted to change. To describe structural change, we compute the mean-square distance (MSD) between monomers in homologous folds separated by n neutral mutations. We find that structural change is episodic, and, averaged over lineages (for example, those extending from a single sequence), exhibits a power-law dependence on n. We show that this exponent depends on the alignment method used, and we analyze the distribution of waiting times between neutral mutations. The latter are more disperse than for models required to maintain a specific fold, but exhibit a similar power-law tail.

Anomalous diffusion in neutral evolution of model proteins

NASA Astrophysics Data System (ADS)

Nelson, Erik D.; Grishin, Nick V.

2015-06-01

Protein evolution is frequently explored using minimalist polymer models, however, little attention has been given to the problem of structural drift, or diffusion. Here, we study neutral evolution of small protein motifs using an off-lattice heteropolymer model in which individual monomers interact as low-resolution amino acids. In contrast to most earlier models, both the length and folded structure of the polymers are permitted to change. To describe structural change, we compute the mean-square distance (MSD) between monomers in homologous folds separated by n neutral mutations. We find that structural change is episodic, and, averaged over lineages (for example, those extending from a single sequence), exhibits a power-law dependence on n . We show that this exponent depends on the alignment method used, and we analyze the distribution of waiting times between neutral mutations. The latter are more disperse than for models required to maintain a specific fold, but exhibit a similar power-law tail.

Termination unit

DOEpatents

Traeholt, Chresten [Frederiksberg, DK; Willen, Dag [Klagshamn, SE; Roden, Mark [Newnan, GA; Tolbert, Jerry C [Carrollton, GA; Lindsay, David [Carrollton, GA; Fisher, Paul W [Heiskell, TN; Nielsen, Carsten Thidemann [Jaegerspris, DK

2014-01-07

This invention relates to a termination unit comprising an end-section of a cable. The end section of the cable defines a central longitudinal axis and comprising end-parts of N electrical phases, an end-part of a neutral conductor and a surrounding thermally insulation envelope adapted to comprising a cooling fluid. The end-parts of the N electrical phases and the end-part of the neutral conductor each comprising at least one electrical conductor and being arranged in the cable concentrically around a core former with a phase 1 located relatively innermost, and phase N relatively outermost in the cable, phase N being surrounded by the neutral conductor, electrical insulation being arrange between neighboring electrical phases and between phase N and the neutral conductor, and wherein the end-parts of the neutral conductor and the electrical phases each comprise a contacting surface electrically connected to at least one branch current lead to provide an electrical connection: The contacting surfaces each having a longitudinal extension, and being located sequentially along the longitudinal extension of the end-section of the cable. The branch current leads being individually insulated from said thermally insulation envelope by individual electrical insulators.

ATTENTION BIAS OF ANXIOUS YOUTH DURING EXTENDED EXPOSURE OF EMOTIONAL FACE PAIRS: AN EYE-TRACKING STUDY

PubMed Central

Shechner, Tomer; Jarcho, Johanna M.; Britton, Jennifer C.; Leibenluft, Ellen; Pine, Daniel S.; Nelson, Eric E.

2012-01-01

Background Previous studies demonstrate that anxiety is characterized by biased attention toward threats, typically measured by differences in motor reaction time to threat and neutral cues. Using eye-tracking methodology, the current study measured attention biases in anxious and nonanxious youth, using unrestricted free viewing of angry, happy, and neutral faces. Methods Eighteen anxious and 15 nonanxious youth (8–17 years old) passively viewed angry-neutral and happy-neutral face pairs for 10 s while their eye movements were recorded. Results Anxious youth displayed a greater attention bias toward angry faces than nonanxious youth, and this bias occurred in the earliest phases of stimulus presentation. Specifically, anxious youth were more likely to direct their first fixation to angry faces, and they made faster fixations to angry than neutral faces. Conclusions Consistent with findings from earlier, reaction-time studies, the current study shows that anxious youth, like anxious adults, exhibit biased orienting to threat-related stimuli. This study adds to the existing literature by documenting that threat biases in eye-tracking patterns are manifest at initial attention orienting. PMID:22815254

Neutral changes during divergent evolution of hemoglobins

NASA Technical Reports Server (NTRS)

Jukes, T. H.

1978-01-01

A comparison of the mRNAs for rabbit and human beta-hemoglobins shows that synonymous changes in codons have accumulated three times as rapidly as nucleotide replacements that produced changes in amino acids. This agrees with predictions based on the so-called neutral theory. In addition, seven codon changes that appear to be single-base changes (according to maximum parsimony) are actually two-base changes. This indicates that the construction of primordial sequences is of limited significance when based on inferences that assume minimum base changes for amino acid replacements.

A neutral lithium beam source

NASA Astrophysics Data System (ADS)

Zhang, XiaoDong; Wang, ZhengMin; Hu, LiQun

1994-04-01

A low energy neutral lithium beam source with energy about 6 keV and a neutral beam equivalent current of 20 μA/cm2 has been developed in ASIPP in order to measure the density gradient and the fluctuations in the edge plasma of the HT-6M tokamak. In the source, lithium ions are extracted from a solid emitter (β-eucryptite), focused in a two-tube immersion lens, and neutralized in a charge-exchange cell with sodium. This source operates in pulsed mode. The pulse length is adjustable from 10 to 100 ms.

Risk Perception and the Public Acceptance of Drones.

PubMed

Clothier, Reece A; Greer, Dominique A; Greer, Duncan G; Mehta, Amisha M

2015-06-01

Unmanned aircraft, or drones, are a rapidly emerging sector of the aviation industry. There has been limited substantive research, however, into the public perception and acceptance of drones. This article presents the results from two surveys of the Australian public designed to investigate (1) whether the public perceive drones to be riskier than existing manned aviation, (2) whether the terminology used to describe the technology influences public perception, and (3) what the broader concerns are that may influence public acceptance of the technology. We find that the Australian public currently hold a relatively neutral attitude toward drones. Respondents did not consider the technology to be overly unsafe, risky, beneficial, or threatening. Drones are largely viewed as being of comparable risk to that of existing manned aviation. Furthermore, terminology had a minimal effect on the perception of the risks or acceptability of the technology. The neutral response is likely due to a lack of knowledge about the technology, which was also identified as the most prevalent public concern as opposed to the risks associated with its use. Privacy, military use, and misuse (e.g., terrorism) were also significant public concerns. The results suggest that society is yet to form an opinion of drones. As public knowledge increases, the current position is likely to change. Industry communication and media coverage will likely influence the ultimate position adopted by the public, which can be difficult to change once established. © 2014 Society for Risk Analysis.

Search for anomalous Wtb couplings and flavour-changing neutral currents in t-channel single top quark production in pp collisions at $$ \\sqrt{s}=7 $$ and 8 TeV

DOE Office of Scientific and Technical Information (OSTI.GOV)

Khachatryan, V.; Sirunyan, A. M.; Tumasyan, A.

Single top quark events produced in the t channel are used to set limits on anomalous Wtb couplings and to search for top quark flavour-changing neutral current (FCNC) interactions. The data taken with the CMS detector at the LHC in proton-proton collisions atmore » $$ \\sqrt{s}=7 $$ and 8 TeV correspond to integrated luminosities of 5.0 and 19.7 fb$$^{-1}$$, respectively. We performed an analysis using events with one muon and two or three jets. A Bayesian neural network technique is used to discriminate between the signal and backgrounds, which are observed to be consistent with the standard model prediction. The 95% confidence level (CL) exclusion limits on anomalous right-handed vector, and left- and right-handed tensor Wtb couplings are measured to be |f$$_{V}^{R}$$ |<0.16, |f$$_{T}^{L}$$ |<0.057, and -0.049 < f$$_{T}^{R}$$<0.048, respectively. Furthermore, for the FCNC couplings κ$$_{tug}$$ and κ$$_{tcg}$$, the 95% CL upper limits on coupling strengths are |κ$$_{tug}$$|/Λ<4.1×10$$^{-3}$$ TeV$$^{-1}$$ and |κ$$_{tcg}$$|/Λ<1.8×10$$^{-2}$$ TeV$$^{-1}$$, where Λ is the scale for new physics, and correspond to upper limits on the branching fractions of 2.0 × 10$$^{-5}$$ and 4.1 × 10$$^{-4}$$ for the decays t → ug and t → cg, respectively.« less

Search for anomalous Wtb couplings and flavour-changing neutral currents in t-channel single top quark production in pp collisions at $$ \\sqrt{s}=7 $$ and 8 TeV

DOE PAGES

Khachatryan, V.; Sirunyan, A. M.; Tumasyan, A.; ...

2017-02-07

Single top quark events produced in the t channel are used to set limits on anomalous Wtb couplings and to search for top quark flavour-changing neutral current (FCNC) interactions. The data taken with the CMS detector at the LHC in proton-proton collisions atmore » $$ \\sqrt{s}=7 $$ and 8 TeV correspond to integrated luminosities of 5.0 and 19.7 fb$$^{-1}$$, respectively. We performed an analysis using events with one muon and two or three jets. A Bayesian neural network technique is used to discriminate between the signal and backgrounds, which are observed to be consistent with the standard model prediction. The 95% confidence level (CL) exclusion limits on anomalous right-handed vector, and left- and right-handed tensor Wtb couplings are measured to be |f$$_{V}^{R}$$ |<0.16, |f$$_{T}^{L}$$ |<0.057, and -0.049 < f$$_{T}^{R}$$<0.048, respectively. Furthermore, for the FCNC couplings κ$$_{tug}$$ and κ$$_{tcg}$$, the 95% CL upper limits on coupling strengths are |κ$$_{tug}$$|/Λ<4.1×10$$^{-3}$$ TeV$$^{-1}$$ and |κ$$_{tcg}$$|/Λ<1.8×10$$^{-2}$$ TeV$$^{-1}$$, where Λ is the scale for new physics, and correspond to upper limits on the branching fractions of 2.0 × 10$$^{-5}$$ and 4.1 × 10$$^{-4}$$ for the decays t → ug and t → cg, respectively.« less

EFFECTS OF ELECTRICAL CURRENTS ON THE ABSORPTION OF WATER BY EGGS OF NEREIS LIMBATA

PubMed Central

Osterhout, W. J. V.

1950-01-01

Unfertilized eggs of the marine worm Nereis limbata subjected to electrical currents (direct or alternating) undergo remarkable changes. Certain minute granules just inside the surface of the egg absorb water and swell to more than 300 times their original size and thereby produce a mass of jelly which surrounds the egg with a zone about as wide as the original diameter of the egg. The amount of direct current is too small to produce any change of color in eggs stained with neutral red. In direct current the jelly appears first on the side toward the anode and moves toward the anode. In alternating current it appears on opposite sides facing the electrodes. It might be thought that the current changes the chemical character of the granules so that they are able to absorb very large quantities of water but this seems unlikely. If the current is shut off after 1 minute the swelling continues. This might be explained on the ground that each jelly precursor granule is covered with a waterproof film which is removed by the current. It does not seem probable that the effect is due to heat produced by the current since the exposure is so short. It seems possible that the current may strip off micelles from the waterproof covering of the granules and allow water to penetrate. The fact that alternating current is more effective than direct current might be explained on the ground that the egg may be represented as a capacity in parallel with a resistance so constituted that relatively little direct current can enter. The non-aqueous film which covers the surface of the protoplasm appears to be liquid rather than solid. PMID:15406375

[Changes in the EEG spectral power during perception of neutral and emotionally salient words in schizophrenic patients, their relatives and healthy individuals from the general population].

PubMed

Alfimova, M V; Uvarova, L G

2007-01-01

To search for EEG-correlates of emotional processing that might be indicators of genetic predisposition to schizophrenia, changes in EEG spectral power during perception of neutral and emotionally salient words were examined in 36 schizophrenic patients, 50 of their unaffected first-degree relatives, and 47 healthy individuals without any family history of psychoses. In healthy persons, passive listening to neutral words induced minimum changes in cortical rhythmical activity, predominantly in the form of synchronization of slow and fast waves, whereas perception of emotional words was followed by a generalized depression of the alpha and beta1 activity and a locally specific decrease in the power of theta and beta2 frequency bands. The patients and their relatives showed a decrease in the alpha and beta1 activity simultaneously with an increase in the power of delta activity in response to both groups of words. Thus, in the patients and their relatives, reactions to neutral and emotional words were ulterior as a result of augmented reactions to the neutral words. These findings suggest that the EEG changes reflect familial and possibly hereditable abnormal involuntary attention. No prominent decrease in reactivity to emotional stimuli was revealed in schizophrenic families.

Sensitivity of the 6300 A twilight airglow to neutral composition

NASA Technical Reports Server (NTRS)

Melendez-Alvira, D. J.; Torr, D. G.; Richards, P. G.; Swift, W. R.; Torr, M. R.; Baldridge, T.; Rassoul, H.

1995-01-01

The field line interhemispheric plasma (FLIP) model is used to study the 6300 A line intensity measured during three morning twilights from the McDonald Observatory in Texas. The Imaging Spectrometric Observatory (ISO) measured the 6300 A intensity during the winter of 1987 and the spring and summer of 1988. The FLIP model reproduces the measured intensity and its variation through the twilight well on each day using neutral densities from the MSIS-86 empirical model. This is in spite of the fact that different component sources dominate the integrated volume emission rate on each of the days analyzed. The sensitivity of the intensity to neutral composition is computed by varying the N2, O2, and O densities in the FLIP model and comparing to the intensity computed with the unmodified MSIS-86 densities. The ion densities change self-consistently. Thus the change in neutral composition also changes the electron density. The F2 peak height is unchanged in the model runs for a given day. The intensity changes near 100 deg SZA are comparable to within 10% when either (O2), (N2), or (O) is changed, regardless of which component source is dominant. There is strong sensitivity to changes in (N2) when dissociative recombination is dominant, virtually no change in the nighttime (SZA greater than or equal to 108 deg) intensity with (O2) doubled, and sensitivity of over 50% to doubling or halving (O) at night. When excitation by conjugate photoelectrons is the dominant nighttime component source, the relative intensity change with (O) doubled or halved is very small. This study shows the strong need for simultaneous measurements of electron density and of emissions proportional to photoelectron fluxes if the 6300 A twilight airglow is to be used to retrieve neutral densities.

76 FR 18930 - Medicare Programs: Changes to the End-Stage Renal Disease Prospective Payment System Transition...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-06

... Payment System Transition Budget-Neutrality Adjustment AGENCY: Centers for Medicare & Medicaid Services... comment will revise the end-stage renal disease (ESRD) transition budget-neutrality adjustment finalized... on April 1, 2011 through December 31, 2011. We are revising the transition budget-neutrality...

High concentration effects of neutral-potential-well interface traps on recombination dc current-voltage lineshape in metal-oxide-silicon transistors

NASA Astrophysics Data System (ADS)

Chen, Zuhui; Jie, Bin B.; Sah, Chih-Tang

2008-11-01

Steady-state Shockley-Read-Hall kinetics is employed to explore the high concentration effect of neutral-potential-well interface traps on the electron-hole recombination direct-current current-voltage (R-DCIV) properties in metal-oxide-silicon field-effect transistors. Extensive calculations include device parameter variations in neutral-trapping-potential-well electron interface-trap density NET (charge states 0 and -1), dopant impurity concentration PIM, oxide thickness Xox, forward source/drain junction bias VPN, and transistor temperature T. It shows significant distortion of the R-DCIV lineshape by the high concentrations of the interface traps. The result suggests that the lineshape distortion observed in past experiments, previously attributed to spatial variation in surface impurity concentration and energy distribution of interface traps in the silicon energy gap, can also arise from interface-trap concentration along surface channel region.

Steady state scenario development with elevated minimum safety factor on DIII-D

DOE PAGES

Holcomb, Christopher T.; Ferron, John R.; Luce, Timothy C.; ...

2014-08-15

On DIII-D, a high β scenario with minimum safety factor (q min) near 1.4 has been optimized with new tools and shown to be a favourable candidate for long pulse or steady state operation in future devices. Furthermore, the new capability to redirect up to 5 MW of neutral beam injection (NBI) from on- to off-axis improves the ability to sustain elevated q min with a less peaked pressure profile. The observed changes increase the ideal magnetohydrodynamics (MHD) n = 1 mode β N limit thus providing a path forward for increasing the noninductive current drive fraction by operating atmore » high β N. Quasi-stationary discharges free of tearing modes have been sustained at βN = 3.5 and β T = 3.6% for two current profile diffusion timescales (about 3 s) limited by neutral beam duration. The discharge performance has normalized fusion performance expected to give fusion gain Q ≈ 5 in a device the size of ITER. Analysis of the poloidal flux evolution and current drive balance show that the loop voltage profile is almost relaxed even with 25% of the current driven inductively, and q min remains elevated near 1.4. Our observations increase confidence that the current profile will not evolve to one unstable to a tearing mode. In preliminary tests a divertor heat flux reduction technique based on producing a radiating mantle with neon injection appears compatible with this operating scenario. 0D model extrapolations suggest it may be possible to push this scenario up to 100% noninductive current drive by raising β N. Similar discharges with q min = 1.5–2 were susceptible to tearing modes and off-axis fishbones, and with q min > 2 lower normalized global energy confinement time is observed.« less

Experimental Investigation of a Hall-Current Accelerator. M.S. Thesis

NASA Technical Reports Server (NTRS)

Plank, G. M.

1983-01-01

The Hall-current accelerator is being investigated for use in the 1000-2000 sec. range of specific impulse. Three models of this thruster were tested. The first two models had three permanent magnets to supply the magnetic field and the third model had six magnets to supply the field. The third model thus had approximately twice the magnetic field of the first two. The first and second models differ only in the shape of the magnetic field. All other factors remained the same for the three models except for the anode-cathode distance, which was changed to allow for the three thrusters to have the same magnetic field integral between the anode and the cathode. These Hall thrusters were tested to determine the plasma properties, the beam characteristics, and the thruster characteristics. The thruster operated in three modes: (1) main cathode only, (2) main cathode with neutralizer cathode, and (3) neutralizer cathode only. The plasma properties were measured along an axial line, 1 mm inside the cathode radius, at a distance of 0.2 to 6.2 cm from the anode. Results show that the current used to heat the cathode produced nonuniformities in the magnetic field, hence also in the plasma properties. In a Hall thruster this general design appears to provide the most thrust when operated at a magnetic field less than the maximum value studied.

A possible mechanism of the enhancement and maintenance of the shear magnetic field component in the current sheet of the Earth’s magnetotail

DOE Office of Scientific and Technical Information (OSTI.GOV)

Grigorenko, E. E., E-mail: elenagrigorenko2003@yahoo.com; Malova, H. V., E-mail: hmalova@yandex.ru; Malykhin, A. Yu., E-mail: anmaurdreg@gmail.com

2015-01-15

The influence of the shear magnetic field component, which is directed along the electric current in the current sheet (CS) of the Earth’s magnetotail and enhanced near the neutral plane of the CS, on the nonadiabatic dynamics of ions interacting with the CS is studied. The results of simulation of the nonadiabatic ion motion in the prescribed magnetic configuration similar to that observed in the magnetotail CS by the CLUSTER spacecraft demonstrated that, in the presence of some initial shear magnetic field, the north-south asymmetry in the ion reflection/refraction in the CS is observed. This asymmetry leads to the formationmore » of an additional current system formed by the oppositely directed electric currents flowing in the northern and southern parts of the plasma sheet in the planes tangential to the CS plane and in the direction perpendicular to the direction of the electric current in the CS. The formation of this current system perhaps is responsible for the enhancement and further maintenance of the shear magnetic field near the neutral plane of the CS. The CS structure and ion dynamics observed in 17 intervals of the CS crossings by the CLUSTER spacecraft is analyzed. In these intervals, the shear magnetic field was increased near the neutral plane of the CS, so that the bell-shaped spatial distribution of this field across the CS plane was observed. The results of the present analysis confirm the suggested scenario of the enhancement of the shear magnetic field near the neutral plane of the CS due to the peculiarities of the nonadiabatic ion dynamics.« less

Plasma fluctuations in a Kaufman thruster. [root mean square magnitude, spectra and cross correlation

NASA Technical Reports Server (NTRS)

Serafini, J. S.; Terdan, F. F.

1973-01-01

Measurements of the RMS magnitude, spectra and cross-correlations for the fluctuations in the beam, discharge and neutralizer keeper currents are presented for a 30-cm diameter dished grid ion thrustor for a range of magnetic baffle currents and up to 2.0 amperes beam current. The ratio of RMS to mean ion beam current varied from 0.04 to 0.23. The spectra of the amplitudes of the beam and discharge current fluctuations were taken up to 9 MHz and show that the predominant amplitudes occur at frequencies of 10 kHz or below. The fall-off with increasing frequency is rapid. Frequencies above 100 kHz the spectral levels are 45 kb or more below the maximum peak amplitudes. The cross-correlations revealed the ion beam fluctuations to have large radial and axial scales which implied that the beam fluctuates as a whole or 'in-phase.' The cross-correlations of the beam and neutralizer keeper current fluctuations indicated the neutralizer contributions to the beam fluctuations to be small, but not negligible. The mode of operation of the thrustor (values of beam and magnetic baffle currents) was significant in determining the RMS magnitude and spectral shape of the beam fluctuations. The major oscillations were not found to be directly dependent on the power conditioner inverter frequencies.

Genetically informed ecological niche models improve climate change predictions.

PubMed

Ikeda, Dana H; Max, Tamara L; Allan, Gerard J; Lau, Matthew K; Shuster, Stephen M; Whitham, Thomas G

2017-01-01

We examined the hypothesis that ecological niche models (ENMs) more accurately predict species distributions when they incorporate information on population genetic structure, and concomitantly, local adaptation. Local adaptation is common in species that span a range of environmental gradients (e.g., soils and climate). Moreover, common garden studies have demonstrated a covariance between neutral markers and functional traits associated with a species' ability to adapt to environmental change. We therefore predicted that genetically distinct populations would respond differently to climate change, resulting in predicted distributions with little overlap. To test whether genetic information improves our ability to predict a species' niche space, we created genetically informed ecological niche models (gENMs) using Populus fremontii (Salicaceae), a widespread tree species in which prior common garden experiments demonstrate strong evidence for local adaptation. Four major findings emerged: (i) gENMs predicted population occurrences with up to 12-fold greater accuracy than models without genetic information; (ii) tests of niche similarity revealed that three ecotypes, identified on the basis of neutral genetic markers and locally adapted populations, are associated with differences in climate; (iii) our forecasts indicate that ongoing climate change will likely shift these ecotypes further apart in geographic space, resulting in greater niche divergence; (iv) ecotypes that currently exhibit the largest geographic distribution and niche breadth appear to be buffered the most from climate change. As diverse agents of selection shape genetic variability and structure within species, we argue that gENMs will lead to more accurate predictions of species distributions under climate change. © 2016 John Wiley & Sons Ltd.

Event-Related Potentials Elicited by Pre-Attentive Emotional Changes in Temporal Context

PubMed Central

Fujimura, Tomomi; Okanoya, Kazuo

2013-01-01

The ability to detect emotional change in the environment is essential for adaptive behavior. The current study investigated whether event-related potentials (ERPs) can reflect emotional change in a visual sequence. To assess pre-attentive processing, we examined visual mismatch negativity (vMMN): the negative potentials elicited by a deviant (infrequent) stimulus embedded in a sequence of standard (frequent) stimuli. Participants in two experiments pre-attentively viewed visual sequences of Japanese kanji with different emotional connotations while ERPs were recorded. The visual sequence in Experiment 1 consisted of neutral standards and two types of emotional deviants with a strong and weak intensity. Although the results indicated that strongly emotional deviants elicited more occipital negativity than neutral standards, it was unclear whether these negativities were derived from emotional deviation in the sequence or from the emotional significance of the deviants themselves. In Experiment 2, the two identical emotional deviants were presented against different emotional standards. One type of deviants was emotionally incongruent with the standard and the other type of deviants was emotionally congruent with the standard. The results indicated that occipital negativities elicited by deviants resulted from perceptual changes in a visual sequence at a latency of 100–200 ms and from emotional changes at latencies of 200–260 ms. Contrary to the results of the ERP experiment, reaction times to deviants showed no effect of emotional context; negative stimuli were consistently detected more rapidly than were positive stimuli. Taken together, the results suggest that brain signals can reflect emotional change in a temporal context. PMID:23671693

Event-related potentials elicited by pre-attentive emotional changes in temporal context.

PubMed

Fujimura, Tomomi; Okanoya, Kazuo

2013-01-01

The ability to detect emotional change in the environment is essential for adaptive behavior. The current study investigated whether event-related potentials (ERPs) can reflect emotional change in a visual sequence. To assess pre-attentive processing, we examined visual mismatch negativity (vMMN): the negative potentials elicited by a deviant (infrequent) stimulus embedded in a sequence of standard (frequent) stimuli. Participants in two experiments pre-attentively viewed visual sequences of Japanese kanji with different emotional connotations while ERPs were recorded. The visual sequence in Experiment 1 consisted of neutral standards and two types of emotional deviants with a strong and weak intensity. Although the results indicated that strongly emotional deviants elicited more occipital negativity than neutral standards, it was unclear whether these negativities were derived from emotional deviation in the sequence or from the emotional significance of the deviants themselves. In Experiment 2, the two identical emotional deviants were presented against different emotional standards. One type of deviants was emotionally incongruent with the standard and the other type of deviants was emotionally congruent with the standard. The results indicated that occipital negativities elicited by deviants resulted from perceptual changes in a visual sequence at a latency of 100-200 ms and from emotional changes at latencies of 200-260 ms. Contrary to the results of the ERP experiment, reaction times to deviants showed no effect of emotional context; negative stimuli were consistently detected more rapidly than were positive stimuli. Taken together, the results suggest that brain signals can reflect emotional change in a temporal context.

The role of weak selection and high mutation rates in nearly neutral evolution.

PubMed

Lawson, Daniel John; Jensen, Henrik Jeldtoft

2009-04-21

Neutral dynamics occur in evolution if all types are 'effectively equal' in their reproductive success, where the definition of 'effectively equal' depends on the population size and the details of mutations. Empirically observed neutral genetic evolution in extremely large clonal populations can only be explained under current models if selection is completely absent. Such models typically consider the case where population dynamics occurs on a different timescale to evolution. However, this assumption is invalid when mutations are not rare in a whole population. We show that this has important consequences for the occurrence of neutral evolution in clonal populations. In highly connected type spaces, neutral dynamics can occur for all population sizes despite significant selective differences, via the forming of effectively neutral networks connecting rare neutral types. Biological implications include an explanation for the high diversity of rare types that survive in large clonal populations, and a theoretical justification for the use of neutral null models.

Emotion in the Neutral Face: A Mechanism for Impression Formation?

PubMed Central

Adams, Reginald B.; Nelson, Anthony J.; Soto, José A.; Hess, Ursula; Kleck, Robert E.

2012-01-01

The current work examined contributions of emotion-resembling facial cues to impression formation. There exist common facial cues that make people look male or female, emotional, and from which we derive personality inferences. We first conducted a Pilot study to assess these effects. We found that neutral female versus neutral male faces were rated as more submissive, affiliative, naïve, honest, cooperative, babyish, fearful, happy, and less angry than neutral male faces. In our Primary Study, we then “warped” these same neutral faces over their corresponding anger and fear displays so the resultant facial appearance cues now structurally resembled emotion while retaining a neutral visage (e.g., no wrinkles, furrows, creases etc.). The gender effects found in the Pilot Study were replicated in the Primary Study, suggesting clear stereotype driven impressions. Critically, ratings of the neutral-over-fear warps versus neutral-over-anger warps also revealed a profile similar to the gender-based ratings, revealing perceptually driven impressions directly attributable to emotion overgeneralization. PMID:22471850

Neutralization of an ion beam from the end-Hall ion source by a plasma electron source based on a discharge in crossed E × H fields

NASA Astrophysics Data System (ADS)

Dostanko, A. P.; Golosov, D. A.

2009-10-01

The possibility of using a plasma electron source (PES) with a discharge in crossed E × H field for compensating the ion beam from an end-Hall ion source (EHIS) is analyzed. The PES used as a neutralizer is mounted in the immediate vicinity of the EHIS ion generation and acceleration region at 90° to the source axis. The behavior of the discharge and emission parameters of the EHIS is determined for operation with a filament neutralizer and a plasma electron source. It is found that the maximal discharge current from the ion source attains a value of 3.8 A for operation with a PES and 4 A for operation with a filament compensator. It is established that the maximal discharge current for the ion source strongly depends on the working gas flow rate for low flow rates (up to 10 ml/min) in the EHIS; for higher flow rates, the maximum discharge current in the EHIS depends only on the emissivity of the PES. Analysis of the emission parameters of EHISs with filament and plasma neutralizers shows that the ion beam current and the ion current density distribution profile are independent of the type of the electron source and the ion current density can be as high as 0.2 mA/cm2 at a distance of 25 cm from the EHIS anode. The balance of currents in the ion source-electron source system is considered on the basis of analysis of operation of EHISs with various sources of electrons. It is concluded that the neutralization current required for operation of an ion source in the discharge compensation mode must be equal to or larger than the discharge current of the ion source. The use of PES for compensating the ion beam from an end-Hall ion source proved to be effective in processes of ion-assisted deposition of thin films using reactive gases like O2 or N2. The application of the PES technique makes it possible to increase the lifetime of the ion-assisted deposition system by an order of magnitude (the lifetime with a Ti cathode is at least 60 h and is limited by the replacement life of the deposited cathode insertion).

pH-induced conformational change of the rotavirus VP4 spike: implications for cell entry and antibody neutralization.

PubMed

Pesavento, Joseph B; Crawford, Sue E; Roberts, Ed; Estes, Mary K; Prasad, B V Venkataram

2005-07-01

The rotavirus spike protein, VP4, is a major determinant of infectivity and neutralization. Previously, we have shown that trypsin-enhanced infectivity of rotavirus involves a transformation of the VP4 spike from a flexible to a rigid bilobed structure. Here we show that at elevated pH the spike undergoes a drastic, irreversible conformational change and becomes stunted, with a pronounced trilobed appearance. These particles with altered spikes, at a normal pH of 7.5, despite the loss of infectivity and the ability to hemagglutinate, surprisingly exhibit sialic acid (SA)-independent cell binding in contrast to the SA-dependent cell binding exhibited by native virions. Remarkably, a neutralizing monoclonal antibody that remains bound to spikes throughout the pH changes (pH 7 to 11 and back to pH 7) completely prevents this conformational change, preserving the SA-dependent cell binding and hemagglutinating functions of the virion. A hypothesis that emerges from the present study is that high-pH treatment triggers a conformational change that mimics a post-SA-attachment step to expose an epitope recognized by a downstream receptor in the rotavirus cell entry process. This process involves sequential interactions with multiple receptors, and the mechanism by which the antibody neutralizes is by preventing this conformational change.

Measurement of Charged and Neutral Current e-p Deep Inelastic Scattering Cross Sections at High Q2

NASA Astrophysics Data System (ADS)

Derrick, M.; Krakauer, D.; Magill, S.; Mikunas, D.; Musgrave, B.; Repond, J.; Stanek, R.; Talaga, R. L.; Zhang, H.; Ayad, R.; Bari, G.; Basile, M.; Bellagamba, L.; Boscherini, D.; Bruni, A.; Bruni, G.; Bruni, P.; Cara Romeo, G.; Castellini, G.; Chiarini, M.; Cifarelli, L.; Cindolo, F.; Contin, A.; Corradi, M.; Gialas, I.; Giusti, P.; Iacobucci, G.; Laurenti, G.; Levi, G.; Margotti, A.; Massam, T.; Nania, R.; Nemoz, C.; Palmonari, F.; Polini, A.; Sartorelli, G.; Timellini, R.; Zamora Garcia, Y.; Zichichi, A.; Bargende, A.; Crittenden, J.; Desch, K.; Diekmann, B.; Doeker, T.; Eckert, M.; Feld, L.; Frey, A.; Geerts, M.; Geitz, G.; Grothe, M.; Haas, T.; Hartmann, H.; Haun, D.; Heinloth, K.; Hilger, E.; Jakob, H.-P.; Katz, U. F.; Mari, S. M.; Mass, A.; Mengel, S.; Mollen, J.; Paul, E.; Rembser, Ch.; Schattevoy, R.; Schramm, D.; Stamm, J.; Wedemeyer, R.; Campbell-Robson, S.; Cassidy, A.; Dyce, N.; Foster, B.; George, S.; Gilmore, R.; Heath, G. P.; Heath, H. F.; Llewellyn, T. J.; Morgado, C. J.; Norman, D. J.; O'Mara, J. A.; Tapper, R. J.; Wilson, S. S.; Yoshida, R.; Rau, R. R.; Arneodo, M.; Iannotti, L.; Schioppa, M.; Susinno, G.; Bernstein, A.; Caldwell, A.; Cartiglia, N.; Parsons, J. A.; Ritz, S.; Sciulli, F.; Straub, P. B.; Wai, L.; Yang, S.; Zhu, Q.; Borzemski, P.; Chwastowski, J.; Eskreys, A.; Piotrzkowski, K.; Zachara, M.; Zawiejski, L.; Adamczyk, L.; Bednarek, B.; Jeleń, K.; Kisielewska, D.; Kowalski, T.; Rulikowska-Zarȩbska, E.; Suszycki, L.; ZajaÇ, J.; Kotański, A.; Przybycień, M.; Bauerdick, L. A.; Behrens, U.; Beier, H.; Bienlein, J. K.; Coldewey, C.; Deppe, O.; Desler, K.; Drews, G.; Flasiński, M.; Gilkinson, D. J.; Glasman, C.; Göttlicher, P.; Grosse-Knetter, J.; Gutjahr, B.; Hain, W.; Hasell, D.; Hessling, H.; Hultschig, H.; Iga, Y.; Joos, P.; Kasemann, M.; Klanner, R.; Koch, W.; Köpke, L.; Kötz, U.; Kowalski, H.; Labs, J.; Ladage, A.; Löhr, B.; Löwe, M.; Lüke, D.; Mańczak, O.; Ng, J. S.; Nickel, S.; Notz, D.; Ohrenberg, K.; Roco, M.; Rohde, M.; Roldán, J.; Schneekloth, U.; Schulz, W.; Selonke, F.; Stiliaris, E.; Surrow, B.; Voss, T.; Westphal, D.; Wolf, G.; Youngman, C.; Zhou, J. F.; Grabosch, H. J.; Kharchilava, A.; Leich, A.; Mattingly, M.; Meyer, A.; Schlenstedt, S.; Wulff, N.; Barbagli, G.; Pelfer, P.; Anzivino, G.; Maccarrone, G.; de Pasquale, S.; Votano, L.; Bamberger, A.; Eisenhardt, S.; Freidhof, A.; Söldner-Rembold, S.; Schroeder, J.; Trefzger, T.; Brook, N. H.; Bussey, P. J.; Doyle, A. T.; Fleck, J. I.; Saxon, D. H.; Utley, M. L.; Wilson, A. S.; Dannemann, A.; Holm, U.; Horstmann, D.; Neumann, T.; Sinkus, R.; Wick, K.; Badura, E.; Burow, B. D.; Hagge, L.; Lohrmann, E.; Mainusch, J.; Milewski, J.; Nakahata, M.; Pavel, N.; Poelz, G.; Schott, W.; Zetsche, F.; Bacon, T. C.; Butterworth, I.; Gallo, E.; Harris, V. L.; Hung, B. Y.; Long, K. R.; Miller, D. B.; Morawitz, P. P.; Prinias, A.; Sedgbeer, J. K.; Whitfield, A. F.; Mallik, U.; McCliment, E.; Wang, M. Z.; Wang, S. M.; Wu, J. T.; Zhang, Y.; Cloth, P.; Filges, D.; An, S. H.; Hong, S. M.; Nam, S. W.; Park, S. K.; Suh, M. H.; Yon, S. H.; Imlay, R.; Kartik, S.; Kim, H.-J.; McNeil, R. R.; Metcalf, W.; Nadendla, V. K.; Barreiro, F.; Cases, G.; Graciani, R.; Hernández, J. M.; Hervás, L.; Labarga, L.; del Peso, J.; Puga, J.; Terron, J.; de Trocóniz, J. F.; Smith, G. R.; Corriveau, F.; Hanna, D. S.; Hartmann, J.; Hung, L. W.; Lim, J. N.; Matthews, C. G.; Patel, P. M.; Sinclair, L. E.; Stairs, D. G.; St. Laurent, M.; Ullmann, R.; Zacek, G.; Bashkirov, V.; Dolgoshein, B. A.; Stifutkin, A.; Bashindzhagyan, G. L.; Ermolov, P. F.; Gladilin, L. K.; Golubkov, Y. A.; Kobrin, V. D.; Kuzmin, V. A.; Proskuryakov, A. S.; Savin, A. A.; Shcheglova, L. M.; Solomin, A. N.; Zotov, N. P.; Botje, M.; Chlebana, F.; Dake, A.; Engelen, J.; de Kamps, M.; Kooijman, P.; Kruse, A.; Tiecke, H.; Verkerke, W.; Vreeswijk, M.; Wiggers, L.; de Wolf, E.; van Woudenberg, R.; Acosta, D.; Bylsma, B.; Durkin, L. S.; Honscheid, K.; Li, C.; Ling, T. Y.; McLean, K. W.; Murray, W. N.; Park, I. H.; Romanowski, T. A.; Seidlein, R.; Bailey, D. S.; Blair, G. A.; Byrne, A.; Cashmore, R. J.; Cooper-Sarkar, A. M.; Daniels, D.; Devenish, R. C.; Harnew, N.; Lancaster, M.; Luffman, P. E.; Lindemann, L.; McFall, J. D.; Nath, C.; Noyes, V. A.; Quadt, A.; Uijterwaal, H.; Walczak, R.; Wilson, F. F.; Yip, T.; Abbiendi, G.; Bertolin, A.; Brugnera, R.; Carlin, R.; dal Corso, F.; de Giorgi, M.; Dosselli, U.; Limentani, S.; Morandin, M.; Posocco, M.; Stanco, L.; Stroili, R.; Voci, C.; Bulmahn, J.; Butterworth, J. M.; Feild, R. G.; Oh, B. Y.; Whitmore, J. J.; D'Agostini, G.; Marini, G.; Nigro, A.; Tassi, E.; Hart, J. C.; McCubbin, N. A.; Prytz, K.; Shah, T. P.; Short, T. L.; Barberis, E.; Dubbs, T.; Heusch, C.; van Hook, M.; Hubbard, B.; Lockman, W.; Rahn, J. T.; Sadrozinski, H. F.-W.; Seiden, A.; Biltzinger, J.; Schwarzer, O.; Seifert, R. J.; Walenta, A. H.; Zech, G.; Abramowicz, H.; Briskin, G.; Dagan, S.; Levy, A.; Hasegawa, T.; Hazumi, M.; Ishii, T.; Kuze, M.; Mine, S.; Nagasawa, Y.; Nakao, M.; Suzuki, I.; Tokushuku, K.; Yamada, S.; Yamazaki, Y.; Chiba, M.; Hamatsu, R.; Hirose, T.; Homma, K.; Kitamura, S.; Nakamitsu, Y.; Yamauchi, K.; Cirio, R.; Costa, M.; Ferrero, M. I.; Lamberti, L.; Maselli, S.; Peroni, C.; Sacchi, R.; Solano, A.; Staiano, A.; Dardo, M.; Bailey, D. C.; Bandyopadhyay, D.; Benard, F.; Brkic, M.; Crombie, M. B.; Gingrich, D. M.; Hartner, G. F.; Joo, K. K.; Levman, G. M.; Martin, J. F.; Orr, R. S.; Sampson, C. R.; Teuscher, R. J.; Catterall, C. D.; Jones, T. W.; Kaziewicz, P. B.; Lane, J. B.; Saunders, R. L.; Shulman, J.; Blankenship, K.; Kochocki, J.; Lu, B.; Mo, L. W.; Bogusz, W.; Charchuła, K.; Ciborowski, J.; Gajewski, J.; Grzelak, G.; Kasprzak, M.; Krzyżanowski, M.; Muchorowski, K.; Nowak, R. J.; Pawlak, J. M.; Tymieniecka, T.; Wróblewski, A. K.; Zakrzewski, J. A.; Żarnecki, A. F.; Adamus, M.; Eisenberg, Y.; Karshon, U.; Revel, D.; Zer-Zion, D.; Ali, I.; Badgett, W. F.; Behrens, B.; Dasu, S.; Fordham, C.; Foudas, C.; Goussiou, A.; Loveless, R. J.; Reeder, D. D.; Silverstein, S.; Smith, W. H.; Vaiciulis, A.; Wodarczyk, M.; Tsurugai, T.; Bhadra, S.; Cardy, M. L.; Fagerstroem, C.-P.; Frisken, W. R.; Furutani, K. M.; Khakzad, M.; Schmidke, W. B.

1995-08-01

Deep inelastic e-p scattering has been studied in both the charged current (CC) and neutral current (NC) reactions at momentum transfers squared Q2 above 400 GeV2 using the ZEUS detector at the HERA ep collider. The CC and NC total cross sections, the NC to CC cross section ratio, and the differential cross sections dσ/dQ2 are presented. From the Q2 dependence of the CC cross section, the mass term in the CC propagator is determined to be MW = 76+/-16+/-13 GeV.

Comparisons of neutrino event generators from an oscillation-experiment perspective

NASA Astrophysics Data System (ADS)

Mayer, Nathan

2015-05-01

Monte Carlo generators are crucial to the analysis of high energy physics data, ideally giving a baseline comparison between the state-of-art theoretical models and experimental data. Presented here is a comparison between three of final state distributions from the GENIE, Neut, NUANCE, and NuWro neutrino Monte Carlo event generators. The final state distributions chosen for comparison are: the electromagnetic energy fraction in neutral current interactions, the energy of the leading π0 vs. the scattering angle for neutral current interactions, and the muon energy vs. scattering angle of νµ charged current interactions.

Neutralizing Antibody Response in Dogs and Cats Inoculated with Commercial Inactivated Rabies Vaccines

PubMed Central

SHIRAISHI, Rikiya; NISHIMURA, Masaaki; NAKASHIMA, Ryuji; ENTA, Chiho; HIRAYAMA, Norio

2013-01-01

ABSTRACT In Japan, the import quarantine regulation against rabies has required from 2005 that dogs and cats should be inoculated with the rabies vaccine and that the neutralizing antibody titer should be confirmed to be at least 0.5 international units (IU)/ml. The fluorescent antibody virus neutralization (FAVN) test is used as an international standard method for serological testing for rabies. To achieve proper immunization of dogs and cats at the time of import and export, changes in the neutralizing antibody titer after inoculation of the rabies vaccine should be understood in detail. However, few reports have provided this information. In this study, we aimed to determine evaluated, such changes by using sera from experimental dogs and cats inoculated with the rabies vaccine, and we tested samples using the routine FAVN test. In both dogs and cats, proper, regular vaccination enabled the necessary titer of neutralizing antibodies to be maintained in the long term. However, inappropriate timing of blood sampling after vaccination could result in insufficient detected levels of neutralizing antibodies. PMID:24389741

Neutralizing antibody response in dogs and cats inoculated with commercial inactivated rabies vaccines.

PubMed

Shiraishi, Rikiya; Nishimura, Masaaki; Nakashima, Ryuji; Enta, Chiho; Hirayama, Norio

2014-04-01

In Japan, the import quarantine regulation against rabies has required from 2005 that dogs and cats should be inoculated with the rabies vaccine and that the neutralizing antibody titer should be confirmed to be at least 0.5 international units (IU)/ml. The fluorescent antibody virus neutralization (FAVN) test is used as an international standard method for serological testing for rabies. To achieve proper immunization of dogs and cats at the time of import and export, changes in the neutralizing antibody titer after inoculation of the rabies vaccine should be understood in detail. However, few reports have provided this information. In this study, we aimed to determine evaluated, such changes by using sera from experimental dogs and cats inoculated with the rabies vaccine, and we tested samples using the routine FAVN test. In both dogs and cats, proper, regular vaccination enabled the necessary titer of neutralizing antibodies to be maintained in the long term. However, inappropriate timing of blood sampling after vaccination could result in insufficient detected levels of neutralizing antibodies.

Collisionless reconnection in a quasi-neutral sheet near marginal stability

NASA Technical Reports Server (NTRS)

Pritchett, P. L.; Coroniti, F. V.; Pellat, R.; Karimabadi, H.

1989-01-01

Particle simulations are used to investigate the process of collisionless reconnection in a magnetotail configuration which includes a pressure gradient along the tail axis and tail flaring. In the absence of electron stabilization effects, the tearing mode is stabilized when the ion gyrofrequency in the normal field exceeds the growth rate in the corresponding one-dimensional current sheet. The presence of a low-frequency electromagnetic perturbation in the lobes can serve to destabilize a marginally stable current sheet by producing an extended neutral-sheet region which can then undergo reconnection. These results help to explain how X-type neutral lines, such as those associated with the onset of magnetospheric substorms, can be formed in the near-earth plasma sheet.

SERT 2 hollow cathode multiple restarts in space

NASA Technical Reports Server (NTRS)

Kerslake, W. R.; Finke, R. C.

1973-01-01

Future missions, both station keeping and primary electric propulsion, will require multiple thrust restarts after periods of inactivity from a few hours to over one year. Although not a part of the original SERT 2 (Space Electric Rocket Test) flight objective, the opportunity to demonstrate multiple cathode restarts in space became available following completion of thruster running. Both neutralizer and main cathodes of each flight thruster were restarted repeatedly following storage periods up to 490 days. No deterioration of cathode heaters was noted nor was any change required in starting voltages or currents.

Parametric investigation of enclosed keeper discharge characteristics

NASA Technical Reports Server (NTRS)

Sheheen, T. W.; Finke, R. C.

1973-01-01

Volt-ampere discharge characteristics of an enclosed keeper hollow cathode discharge were measured as a function of the mercury flow rate and external circuit impedance. Discharge currents were varied from 0 to 1 ampere and voltages were 7 to 39 volts. Batteries and a vacuum tube control circuit were used to obtain characteristics curves that were independent of power supply impedance. Variation of the neutral flow results in changes in the discharge which interact with the impedance of the external circuit, and under some conditions, give rise to multiple operating points.

Self-induced steady-state magnetic field in the negative ion sources with localized rf power deposition

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shivarova, A.; Todorov, D., E-mail: dimitar-tdrv@phys.uni-sofia-bg; Lishev, St.

2016-02-15

The study is in the scope of a recent activity on modeling of SPIDER (Source for Production of Ions of Deuterium Extracted from RF plasma) which is under development regarding the neutral beam injection heating system of ITER. The regime of non-ambipolarity in the source, established before, is completed here by introducing in the model the steady state magnetic field, self-induced in the discharge due to the dc current flowing in it. Strong changes in the discharge structure are reported.

Disturbance, neutral theory, and patterns of beta diversity in soil communities.

PubMed

Maaß, Stefanie; Migliorini, Massimo; Rillig, Matthias C; Caruso, Tancredi

2014-12-01

Beta diversity describes how local communities within an area or region differ in species composition/abundance. There have been attempts to use changes in beta diversity as a biotic indicator of disturbance, but lack of theory and methodological caveats have hampered progress. We here propose that the neutral theory of biodiversity plus the definition of beta diversity as the total variance of a community matrix provide a suitable, novel, starting point for ecological applications. Observed levels of beta diversity (BD) can be compared to neutral predictions with three possible outcomes: Observed BD equals neutral prediction or is larger (divergence) or smaller (convergence) than the neutral prediction. Disturbance might lead to either divergence or convergence, depending on type and strength. We here apply these ideas to datasets collected on oribatid mites (a key, very diverse soil taxon) under several regimes of disturbances. When disturbance is expected to increase the heterogeneity of soil spatial properties or the sampling strategy encompassed a range of diverging environmental conditions, we observed diverging assemblages. On the contrary, we observed patterns consistent with neutrality when disturbance could determine homogenization of soil properties in space or the sampling strategy encompassed fairly homogeneous areas. With our method, spatial and temporal changes in beta diversity can be directly and easily monitored to detect significant changes in community dynamics, although the method itself cannot inform on underlying mechanisms. However, human-driven disturbances and the spatial scales at which they operate are usually known. In this case, our approach allows the formulation of testable predictions in terms of expected changes in beta diversity, thereby offering a promising monitoring tool.

Population growth enhances the mean fixation time of neutral mutations and the persistence of neutral variation.

PubMed

Waxman, D

2012-06-01

A fundamental result of population genetics states that a new mutation, at an unlinked neutral locus in a randomly mating diploid population, has a mean time of fixation of ∼4N(e) generations, where N(e) is the effective population size. This result is based on an assumption of fixed population size, which does not universally hold in natural populations. Here, we analyze such neutral fixations in populations of changing size within the framework of the diffusion approximation. General expressions are derived for the mean and variance of the fixation time in changing populations. Some explicit results are given for two cases: (i) the effective population size undergoes a sudden change, representing a sudden population expansion or a sudden bottleneck; (ii) the effective population changes linearly for a limited period of time and then remains constant. Additionally, a lower bound for the mean time of fixation is obtained for an effective population size that increases with time, and this is applied to exponentially growing populations. The results obtained in this work show, among other things, that for populations that increase in size, the mean time of fixation can be enhanced, sometimes substantially so, over 4N(e,0) generations, where N(e,0) is the effective population size at the time the mutation arises. Such an enhancement is associated with (i) an increased probability of neutral polymorphism in a population and (ii) an enhanced persistence of high-frequency neutral variation, which is the variation most likely to be observed.

Effects of a new bicarbonate/lactate-buffered neutral peritoneal dialysis fluid for peritoneal failure in patients undergoing peritoneal dialysis.

PubMed

Hoshino, Taro; Ishii, Hiroki; Kitano, Taisuke; Shindo, Mitsutoshi; Miyazawa, Haruhisa; Yamada, Hodaka; Ito, Kiyonori; Ueda, Yuichiro; Kaku, Yoshio; Hirai, Keiji; Mori, Honami; Ookawara, Susumu; Tabei, Kaoru; Morishita, Yoshiyuki

2016-02-01

The highly concentrated lactate in peritoneal dialysis fluid (PDF) has been considered to contribute to peritoneal failure in patients undergoing PD. A new PDF containing a lower lactate concentration, physiological bicarbonate concentration, and neutral pH (bicarbonate/lactate-buffered neutral PDF) was recently developed. We compared the clinical effects of this bicarbonate/lactate-buffered neutral PDF and a lactate-buffered neutral PDF. Patients undergoing PD were changed from a lactate-buffered neutral PDF to a bicarbonate/lactate-buffered neutral PDF. We then investigated the changes in peritoneal functions as estimated by a peritoneal equilibration test (PET) and the following surrogate markers of peritoneal membrane failure in the drained dialysate: fibrin degradation products (FDP), vascular endothelial growth factor (VEGF), cancer antigen 125 (CA125), interleukin-6 (IL-6), and transforming growth factor beta 1 (TGF-β1). Fourteen patients undergoing PD were enrolled. The PET results were not different before and after use of the bicarbonate/lactate-buffered neutral PDF. The FDP concentration significantly decreased from 15.60 ± 13.90 to 6.04 ± 3.49 μg/mL (p = 0.02) and the VEGF concentration significantly decreased from 37.83 ± 15.82 to 27.70 ± 3.80 pg/mL (p = 0.02), while the CA125 and IL-6 concentrations remained unchanged before and after use of the bicarbonate/lactate-buffered neutral PDF. TGF-β1 was not detected in most patients. The bicarbonate/lactate-buffered neutral PDF decreased the FDP and VEGF concentrations in the drained dialysate. These results suggest that the decreased lactate level achieved by administration of bicarbonate with a neutral pH in PDF may contribute to decreased peritoneal membrane failure in patients undergoing PD.

Looking at food in sad mood: do attention biases lead emotional eaters into overeating after a negative mood induction?

PubMed

Werthmann, Jessica; Renner, Fritz; Roefs, Anne; Huibers, Marcus J H; Plumanns, Lana; Krott, Nora; Jansen, Anita

2014-04-01

Emotional eating is associated with overeating and the development of obesity. Yet, empirical evidence for individual (trait) differences in emotional eating and cognitive mechanisms that contribute to eating during sad mood remain equivocal. The aim of this study was to test if attention bias for food moderates the effect of self-reported emotional eating during sad mood (vs neutral mood) on actual food intake. It was expected that emotional eating is predictive of elevated attention for food and higher food intake after an experimentally induced sad mood and that attentional maintenance on food predicts food intake during a sad versus a neutral mood. Participants (N = 85) were randomly assigned to one of the two experimental mood induction conditions (sad/neutral). Attentional biases for high caloric foods were measured by eye tracking during a visual probe task with pictorial food and neutral stimuli. Self-reported emotional eating was assessed with the Dutch Eating Behavior Questionnaire (DEBQ) and ad libitum food intake was tested by a disguised food offer. Hierarchical multivariate regression modeling showed that self-reported emotional eating did not account for changes in attention allocation for food or food intake in either condition. Yet, attention maintenance on food cues was significantly related to increased intake specifically in the neutral condition, but not in the sad mood condition. The current findings show that self-reported emotional eating (based on the DEBQ) might not validly predict who overeats when sad, at least not in a laboratory setting with healthy women. Results further suggest that attention maintenance on food relates to eating motivation when in a neutral affective state, and might therefore be a cognitive mechanism contributing to increased food intake in general, but maybe not during sad mood. Copyright © 2014 Elsevier Ltd. All rights reserved.

Limits of neutral drift: lessons from the in vitro evolution of two ribozymes.

PubMed

Petrie, Katherine L; Joyce, Gerald F

2014-10-01

The relative contributions of adaptive selection and neutral drift to genetic change are unknown but likely depend on the inherent abundance of functional genotypes in sequence space and how accessible those genotypes are to one another. To better understand the relative roles of selection and drift in evolution, local fitness landscapes for two different RNA ligase ribozymes were examined using a continuous in vitro evolution system under conditions that foster the capacity for neutral drift to mediate genetic change. The exploration of sequence space was accelerated by increasing the mutation rate using mutagenic nucleotide analogs. Drift was encouraged by carrying out evolution within millions of separate compartments to exploit the founder effect. Deep sequencing of individuals from the evolved populations revealed that the distribution of genotypes did not escape the starting local fitness peak, remaining clustered around the sequence used to initiate evolution. This is consistent with a fitness landscape where high-fitness genotypes are sparse and well isolated, and suggests, at least in this context, that neutral drift alone is not a primary driver of genetic change. Neutral drift does, however, provide a repository of genetic variation upon which adaptive selection can act.

Neutrino oscillation processes in a quantum-field-theoretical approach

NASA Astrophysics Data System (ADS)

Egorov, Vadim O.; Volobuev, Igor P.

2018-05-01

It is shown that neutrino oscillation processes can be consistently described in the framework of quantum field theory using only the plane wave states of the particles. Namely, the oscillating electron survival probabilities in experiments with neutrino detection by charged-current and neutral-current interactions are calculated in the quantum field-theoretical approach to neutrino oscillations based on a modification of the Feynman propagator in the momentum representation. The approach is most similar to the standard Feynman diagram technique. It is found that the oscillating distance-dependent probabilities of detecting an electron in experiments with neutrino detection by charged-current and neutral-current interactions exactly coincide with the corresponding probabilities calculated in the standard approach.

Optical measurements of Na-Ca-K exchange currents in intact outer segments isolated from bovine retinal rods

PubMed Central

1991-01-01

The properties of Na-Ca-K exchange current through the plasma membrane of intact rod outer segments (ROS) isolated from bovine retinas were studied with the optical probe neutral red. Small cellular organelles such as bovine ROS do not offer an adequate collecting area to measure Na-Ca-K exchange currents with electrophysiological techniques. This study demonstrates that Na-Ca-K exchange current in bovine ROS can be measured with the dye neutral red and dual-wavelength spectrophotometry. The binding of neutral red is sensitive to transport of cations across the plasma membrane of ROS by the effect of the translocated cations on the surface potential of the intracellular disk membranes (1985. J. Membr. Biol. 88: 249-262). Electrogenic Na+ fluxes through the ROS plasma membrane were measured with a resolution of 10(5) Na+ ions/ROS per s, equivalent to a current of approximately 0.01 pA; maximal electrogenic Na-Ca-K exchange flux in bovine ROS was equivalent to a maximal exchange current of 1-2 pA. Electrogenic Na+ fluxes were identified as Na-Ca-K exchange current based on a comparison between electrogenic Na+ flux and Na(+)-stimulated Ca2+ release with respect to flux rate, Na+ dependence, and ion selectivity. Neutral red monitored the net entry of a single positive charge carried by Na+ for each Ca2+ ion released (i.e., monitored the Na-Ca-K exchange current). Na-Ca-K exchange in the plasma membrane of bovine ROS had the following properties: (a) Inward Na-Ca-K exchange current required internal Ca2+ (half-maximal stimulation at a free Ca2+ concentration of 0.9 microM), whereas outward Na-Ca-K exchange current required both external Ca2+ (half-maximal stimulation at a free Ca2+ concentration of 1.1 microM) and external K+. (b) Inward Na-Ca-K exchange current depended in a sigmoidal manner on the external Na+ concentration, identical to Na(+)-stimulated Ca2+ release measured with Ca(2+)- indicating dyes. (c) The neutral red method was modified to measure Ca(2+)-activated K+ fluxes (half-maximal stimulation at 2.7 microM free Ca2+) via the Na-Ca-K exchanger in support of the notion that the rod Na-Ca exchanger is in effect a Na-Ca-K exchanger. (d) Competitive interactions between Ca2+ and Na+ ions on the exchanger protein are described. PMID:1722239

Whole-lake neutralization experiments in Ontario: a review. [Salvelinus fontinalis; Etheostoma exile; Culaea inconstans; Microterus dolomieui

DOE Office of Scientific and Technical Information (OSTI.GOV)

Scheider, W.A.; Brydges, T.G.

A review is presented which summarizes studies performed in Sudbury, Ontario area lakes during 1973-1979 and outlines an ongoing study which began in 1981. All lakes were neutralized with Ca(OH)/sub 2/ and CaCO/sub 3/ resulting in pH changes. Levels increased from 4.1 to 7.5 and remained high during the study. Following neutralization, waterborne levels of Cu were reduced by 48-95% from pretreatment values of 80-1100 ..mu..g/L/sup -1/ and Ni levels declined by 23-91% from pretreatment values of 250-1900 ..mu..gL/sup -1/. An immediate decline in phytoplankton standing stock followed neutralization but levels returned to pretreatment values within a few months. Phytoplanktonmore » community composition changed such that chrysophytes and diatoms replaced Cryptophyceae and Dinophyceae as dominants. Lakes were stocked with brook trout, Iowa darters, brook stickleback and smallmouth bass after neutralization. Extensive netting yielded no fish and mortality was attributed to Cu toxicity. Further lake neutralization experiments are being conducted to test the feasibility of whole-lake or site-specific neutralization to protect aquatic systems from further damage due to acidic precipitation, and to test the feasibility of using neutralization to rehabilitate an acidified, clear-water lake with low Cu and Ni levels to the point of establishing a self-sustaining lake trout population.« less

Development of a low-energy and high-current pulsed neutral beam injector with a washer-gun plasma source for high-beta plasma experiments.

PubMed

Ii, Toru; Gi, Keii; Umezawa, Toshiyuki; Asai, Tomohiko; Inomoto, Michiaki; Ono, Yasushi

2012-08-01

We have developed a novel and economical neutral-beam injection system by employing a washer-gun plasma source. It provides a low-cost and maintenance-free ion beam, thus eliminating the need for the filaments and water-cooling systems employed conventionally. In our primary experiments, the washer gun produced a source plasma with an electron temperature of approximately 5 eV and an electron density of 5 × 10(17) m(-3), i.e., conditions suitable for ion-beam extraction. The dependence of the extracted beam current on the acceleration voltage is consistent with space-charge current limitation, because the observed current density is almost proportional to the 3/2 power of the acceleration voltage below approximately 8 kV. By optimizing plasma formation, we successfully achieved beam extraction of up to 40 A at 15 kV and a pulse length in excess of 0.25 ms. Its low-voltage and high-current pulsed-beam properties enable us to apply this high-power neutral beam injection into a high-beta compact torus plasma characterized by a low magnetic field.

Distribution of Region 1 and 2 currents in the quietand substorm time plasma sheetfrom THEMIS observations

NASA Astrophysics Data System (ADS)

Liu, J.; Angelopoulos, V.; Chu, X.; McPherron, R. L.

2016-12-01

Although Earth's Region 1 and 2 currents are related to activities such as substorm initiation, their magnetospheric origin remains unclear. Utilizing the triangular configuration of THEMIS probes at 8-12 RE downtail, we seek the origin of nightside Region 1 and 2 currents. The triangular configuration allows a curlometer-like technique which do not rely on active-time boundary crossings, so we can examine the current distribution in quiet times as well as active times. Our statistical study reveals that both Region 1 and 2 currents exist in the plasma sheet during quiet and active times. Especially, this is the first unequivocal, in-situ evidence of the existence of Region 2 currents in the plasma sheet. Farther away from the neutral sheet than the Region 2 currents lie the Region 1 currents which extend at least to the plasma sheet boundary layer. At geomagnetic quiet times, the separation between the two currents is located 2.5 RE from the neutral sheet. These findings suggest that the plasma sheet is a source of Region 1 and 2 currents regardless of geomagnetic activity level. During substorms, the separation between Region 1 and 2 currents migrates toward (away from) the neutral sheet as the plasma sheet thins (thickens). This migration indicates that the deformation of Region 1 and 2 currents is associated with redistribution of FAC sources in the magnetotail. In some substorms when the THEMIS probes encounter a dipolarization, a substorm current wedge (SCW) can be inferred from our technique, and it shows a distinctively larger current density than the pre-existing Region 1 currents. This difference suggests that the SCW is not just an enhancement of the pre-existing Region 1 current; the SCW and the Region 1 currents have different sources.

Identification of pleasant, neutral, and unpleasant odors in schizophrenia

PubMed Central

Kamath, Vidyulata; Turetsky, Bruce I.; Moberg, Paul J.

2010-01-01

Recent work on odor hedonics in schizophrenia has indicated that patients display abnormalities in hedonic judgments of odors in comparison to healthy comparison participants. In the current study, identification accuracy for pleasant, neutral, and unpleasant odors in individuals with schizophrenia and healthy controls was examined. Thirty-three schizophrenia patients (63% male) and thirty-one healthy volunteers (65% male) were recruited. The groups were well matched on age, sex, and smoking status. Participants were administered the University of Pennsylvania Smell Identification Test, which was subsequently divided into 16 pleasant, 15 neutral, and 9 unpleasant items. Analysis of identification z-scores for pleasant, neutral, and unpleasant odors revealed a significant diagnosis by valence interaction. Post-hoc analysis revealed that schizophrenia participants made more identification errors on pleasant and neutral odors compared to healthy controls, with no differences observed for unpleasant odors. No effect was seen for sex. The findings from the current investigation suggest that odor identification accuracy in patients is influenced by odor valence. This pattern of results parallels a growing body of literature indicating that patients display aberrant pleasantness ratings for pleasant odors and highlights the need for additional research on the influence of odor valence on olfactory identification performance in individuals with schizophrenia. PMID:21239063

Neutral beam dose and sputtering characteristics in an ion implantation system

NASA Technical Reports Server (NTRS)

Roberts, A. S., Jr.; Ash, R. L.; Berger, M. H.

1973-01-01

A technique and instrument design for calorimetric detection of the neutral atom content of a 60 keV argon ion beam. A beam sampling method is used to measure local heat flux to a small platinum wire at steady state; integration of power density profiles leads to a determination of equivalent neutral beam current. The fast neutral production occurs as a result of charge transfer processes in the region of the beam system between analyzing magnet and beam stop where the pressure remains less than .00001 torr. A description of the neutral beam detector is given in section along with a presentation of results. An elementary analysis of sputter material transport from target to substrate was performed; the analysis relates to semiconductor sputtering.

How children remember neutral and emotional pictures: boundary extension in children's scene memories.

PubMed

Candel, Ingrid; Merckelbach, Harald; Houben, Katrijn; Vandyck, Inne

2004-01-01

Boundary extension is the tendency to remember more of a scene than was actually shown. The dominant interpretation of this memory illusion is that it originates from schemata that people construct when viewing a scene. Evidence of boundary extension has been obtained primarily with adult participants who remember neutral pictures. The current study addressed the developmental stability of this phenomenon. Therefore, we investigated whether children aged 10-12 years display boundary extension for neutral pictures. Moreover, we examined emotional scene memory. Eighty-seven children drew pictures from memory after they had seen either neutral or emotional pictures. Both their neutral and emotional drawings revealed boundary extension. Apparently, the schema construction that underlies boundary extension is a robust and ubiquitous process.

Campus-Wide Measures Have Greater Potential | Climate Neutral Research

Science.gov Websites

impacts of climate change and fossil-fuel depletion. International scientific bodies addressing climate Potential Pursuing climate neutrality on research campuses fits into the bigger picture of addressing the change are calling for reductions of carbon emissions of 80% by 2050. Because of their size and

A new balancing three level three dimensional space vector modulation strategy for three level neutral point clamped four leg inverter based shunt active power filter controlling by nonlinear back stepping controllers.

PubMed

Chebabhi, Ali; Fellah, Mohammed Karim; Kessal, Abdelhalim; Benkhoris, Mohamed F

2016-07-01

In this paper is proposed a new balancing three-level three dimensional space vector modulation (B3L-3DSVM) strategy which uses a redundant voltage vectors to realize precise control and high-performance for a three phase three-level four-leg neutral point clamped (NPC) inverter based Shunt Active Power Filter (SAPF) for eliminate the source currents harmonics, reduce the magnitude of neutral wire current (eliminate the zero-sequence current produced by single-phase nonlinear loads), and to compensate the reactive power in the three-phase four-wire electrical networks. This strategy is proposed in order to gate switching pulses generation, dc bus voltage capacitors balancing (conserve equal voltage of the two dc bus capacitors), and to switching frequency reduced and fixed of inverter switches in same times. A Nonlinear Back Stepping Controllers (NBSC) are used for regulated the dc bus voltage capacitors and the SAPF injected currents to robustness, stabilizing the system and to improve the response and to eliminate the overshoot and undershoot of traditional PI (Proportional-Integral). Conventional three-level three dimensional space vector modulation (C3L-3DSVM) and B3L-3DSVM are calculated and compared in terms of error between the two dc bus voltage capacitors, SAPF output voltages and THDv, THDi of source currents, magnitude of source neutral wire current, and the reactive power compensation under unbalanced single phase nonlinear loads. The success, robustness, and the effectiveness of the proposed control strategies are demonstrated through simulation using Sim Power Systems and S-Function of MATLAB/SIMULINK. Copyright © 2016 ISA. Published by Elsevier Ltd. All rights reserved.

Changing US Attributes After CS-US Pairings Changes CS-Attribute-Assessments: Evidence for CS-US Associations in Attribute Conditioning.

PubMed

Förderer, Sabine; Unkelbach, Christian

2016-03-01

Attribute Conditioning (AC) refers to people's changed assessments of stimuli's (CSs) attributes due to repeated pairing with stimuli (USs) possessing these attributes; for example, when an athletic person (US) is paired with a neutral person (CS), the neutral person is judged to be more athletic after the pairing. We hypothesize that this AC effect is due to CSs' associations with USs rather than direct associations with attributes. Three experiments test this hypothesis by changing US attributes after CS-US pairings. Experiments 1 and 2 conditioned athleticism by pairing neutral men (CSs) with athletic and non-athletic USs. Post-conditioning, USs' athleticism was reversed, which systematically influenced participants' assessment of CS athleticism. Experiment 3 conditioned athleticism and changed USs' musicality after CS-US pairings. This post-conditioning change affected musicality assessments of CSs but did not influence athleticism-assessments. The results indicate that AC effects are based on an associative CS-US-attribute structure. © 2016 by the Society for Personality and Social Psychology, Inc.

Reconstruction of Pressure Profile Evolution during Levitated Dipole Experiments

NASA Astrophysics Data System (ADS)

Mauel, M.; Garnier, D.; Boxer, A.; Ellsworth, J.; Kesner, J.

2008-11-01

Magnetic levitation of the LDX superconducting dipole causes significant changes in the measured diamagnetic flux and what appears to be an isotropic plasma pressure profile (p˜p||). This poster describes the reconstruction of plasma current and plasma pressure profiles from external measurements of the equilibrium magnetic field, which vary substantially as a function of time depending upon variations in neutral pressure and multifrequency ECRH power levels. Previous free-boundary reconstructions of plasma equilibrium showed the plasma to be anisotropic and highly peaked at the location of the cyclotron resonance of the microwave heating sources. Reconstructions of the peaked plasma pressures confined by a levitated dipole incorporate the small axial motion of the dipole (±5 mm), time varying levitation coil currents, eddy currents flowing in the vacuum vessel, constant magnetic flux linking the superconductor, and new flux loops located near the hot plasma in order to closely couple to plasma current and dipole current variations. I. Karim, et al., J. Fusion Energy, 26 (2007) 99.

Effects of running the Bostom Marathon on plasma concentrations of large neutral amino acids

NASA Technical Reports Server (NTRS)

Conlay, L. A.; Wurtman, R. J.; Lopez G-Coviella, I.; Blusztajn, J. K.; Vacanti, C. A.; Logue, M.; During, M.; Caballero, B.; Maher, T. J.; Evoniuk, G.

1989-01-01

Plasma large neutral amino acid concentrations were measured in thirty-seven subjects before and after completing the Boston Marathon. Concentrations of tyrosine, phenylalanine, and methionine increased, as did their 'plasma ratios' (i.e., the ratio of each amino acid's concentration to the summed plasma concentrations of the other large neutral amino acids which compete with it for brain uptake). No changes were noted in the plasma concentrations of tryptophan, leucine, isoleucine, nor valine; however, the 'plasma ratios' of valine, leucine, and isoleucine all decreased. These changes in plasma amino acid patterns may influence neurotransmitter synthesis.

Steady-state analysis of a faulted three-phase four-wire system supplying induction motors with neutrals connected and other single-phase line-to-neutral loads

NASA Technical Reports Server (NTRS)

Wood, M. E.

1980-01-01

Four wire Wye connected ac power systems exhibit peculiar steady state fault characteristics when the fourth wire of three phase induction motors is connected. The loss of one phase of power source due to a series or shunt fault results in currents higher than anticipated on the remaining two phases. A theoretical approach to compute the fault currents and voltages is developed. A FORTRAN program is included in the appendix.

Shifting species interactions in terrestrial dryland ecosystems under altered water availability and climate change

USGS Publications Warehouse

McCluney, Kevin E.; Belnap, Jayne; Collins, Scott L.; González, Angélica L.; Hagen, Elizabeth M.; Holland, J. Nathaniel; Kotler, Burt P.; Maestre, Fernando T.; Smith, Stanley D.; Wolf, Blair O.

2012-01-01

Species interactions play key roles in linking the responses of populations, communities, and ecosystems to environmental change. For instance, species interactions are an important determinant of the complexity of changes in trophic biomass with variation in resources. Water resources are a major driver of terrestrial ecology and climate change is expected to greatly alter the distribution of this critical resource. While previous studies have documented strong effects of global environmental change on species interactions in general, responses can vary from region to region. Dryland ecosystems occupy more than one-third of the Earth's land mass, are greatly affected by changes in water availability, and are predicted to be hotspots of climate change. Thus, it is imperative to understand the effects of environmental change on these globally significant ecosystems. Here, we review studies of the responses of population-level plant-plant, plant-herbivore, and predator-prey interactions to changes in water availability in dryland environments in order to develop new hypotheses and predictions to guide future research. To help explain patterns of interaction outcomes, we developed a conceptual model that views interaction outcomes as shifting between (1) competition and facilitation (plant-plant), (2) herbivory, neutralism, or mutualism (plant-herbivore), or (3) neutralism and predation (predator-prey), as water availability crosses physiological, behavioural, or population-density thresholds. We link our conceptual model to hypothetical scenarios of current and future water availability to make testable predictions about the influence of changes in water availability on species interactions. We also examine potential implications of our conceptual model for the relative importance of top-down effects and the linearity of patterns of change in trophic biomass with changes in water availability. Finally, we highlight key research needs and some possible broader impacts of our findings. Overall, we hope to stimulate and guide future research that links changes in water availability to patterns of species interactions and the dynamics of populations and communities in dryland ecosystems.

An ultrasensitive universal detector based on neutralizer displacement

NASA Astrophysics Data System (ADS)

Das, Jagotamoy; Cederquist, Kristin B.; Zaragoza, Alexandre A.; Lee, Paul E.; Sargent, Edward H.; Kelley, Shana O.

2012-08-01

Diagnostic technologies that can provide the simultaneous detection of nucleic acids for gene expression, proteins for host response and small molecules for profiling the human metabolome will have a significant advantage in providing comprehensive patient monitoring. Molecular sensors that report changes in the electrostatics of a sensor's surface on analyte binding have shown unprecedented sensitivity in the detection of charged biomolecules, but do not lend themselves to the detection of small molecules, which do not carry significant charge. Here, we introduce the neutralizer displacement assay that allows charge-based sensing to be applied to any class of molecule irrespective of the analyte charge. The neutralizer displacement assay starts with an aptamer probe bound to a neutralizer. When analyte binding occurs the neutralizer is displaced, which results in a dramatic change in the surface charge for all types of analytes. We have tested the sensitivity, speed and specificity of this system in the detection of a panel of molecules: (deoxy)ribonucleic acid, ribonucleic acid, cocaine, adenosine triphosphate and thrombin.

Set-shifting abilities, mood and loss of control over eating in binge eating disorder: An experimental study.

PubMed

Dingemans, Alexandra E; Visser, Hiske; Paul, Linda; van Furth, Eric F

2015-12-15

Executive functions play an important role in problem-solving and self-control. Set-shifting is an aspect of executive functioning and represents cognitive flexibility. The inability to control eating in Binge Eating Disorder (BED) may imply deficits in set-shifting which could be exacerbated by negative mood and depressive symptoms. The aim of the study was to test whether there is a causal relationship between set-shifting ability, changes in mood and loss of control over eating in BED. Seventy-five participants diagnosed with BED were randomly assigned to a negative or neutral mood induction. Set-shifting abilities, depressive symptoms, current mood and loss of control over eating were assessed. Having depressive symptoms and poorer set-shifting abilities resulted in a more negative mood after a negative mood induction, whereas this was not observed in the neutral mood induction. Post-hoc analyses revealed that individuals with poorer set-shifting abilities and more changes in negative mood, experienced more feelings of loss of control over eating than individuals whose set-shifting abilities were better and whose mood did not change. The results suggest that both depressive symptoms and deficits in set-shifting abilities may decrease an individual's ability to handle negative affect and increase loss of control over eating in individuals with BED. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Internal transport barrier triggered by non-linear lower hybrid wave deposition under condition of beam-driven toroidal rotation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gao, Q. D., E-mail: qgao@swip.ac.cn; Budny, R. V.

2015-03-15

By using gyro-Landau fluid transport model (GLF23), time-dependent integrated modeling is carried out using TRANSP to explore the dynamic process of internal transport barrier (ITB) formation in the neutral beam heating discharges. When the current profile is controlled by LHCD (lower hybrid current drive), with appropriate neutral beam injection, the nonlinear interplay between the transport determined gradients in the plasma temperature (T{sub i,e}) and toroidal velocity (V{sub ϕ}) and the E×B flow shear (including q-profile) produces transport bifurcations, generating spontaneously a stepwise growing ITB. In the discharge, the constraints imposed by the wave propagation condition causes interplay of the LHmore » driven current distribution with the plasma configuration modification, which constitutes non-linearity in the LH wave deposition. The non-linear effects cause bifurcation in LHCD, generating two distinct quasi-stationary reversed magnetic shear configurations. The change of current profile during the transition period between the two quasi-stationary states results in increase of the E×B shearing flow arising from toroidal rotation. The turbulence transport suppression by sheared E×B flow during the ITB development is analysed, and the temporal evolution of some parameters characterized the plasma confinement is examined. Ample evidence shows that onset of the ITB development is correlated with the enhancement of E×B shearing rate caused by the bifurcation in LHCD. It is suggested that the ITB triggering is associated with the non-linear effects of the LH power deposition.« less

Contribution of Field Strength Gradients to the Net Vertical Current of Active Regions

NASA Astrophysics Data System (ADS)

Vemareddy, P.

2017-12-01

We examined the contribution of field strength gradients for the degree of net vertical current (NVC) neutralization in active regions (ARs). We used photospheric vector magnetic field observations of AR 11158 obtained by Helioseismic and Magnetic Imager on board SDO and Hinode. The vertical component of the electric current is decomposed into twist and shear terms. The NVC exhibits systematic evolution owing to the presence of the sheared polarity inversion line between rotating and shearing magnetic regions. We found that the sign of shear current distribution is opposite in dominant pixels (60%–65%) to that of twist current distribution, and its time profile bears no systematic trend. This result indicates that the gradient of magnetic field strength contributes to an opposite signed, though smaller in magnitude, current to that contributed by the magnetic field direction in the vertical component of the current. Consequently, the net value of the shear current is negative in both polarity regions, which when added to the net twist current reduces the direct current value in the north (B z > 0) polarity, resulting in a higher degree of NVC neutralization. We conjecture that the observed opposite signs of shear and twist currents are an indication, according to Parker, that the direct volume currents of flux tubes are canceled by their return currents, which are contributed by field strength gradients. Furthermore, with the increase of spatial resolution, we found higher values of twist, shear current distributions. However, the resolution effect is more useful in resolving the field strength gradients, and therefore suggests more contribution from shear current for the degree of NVC neutralization.

Exploration of a possible cause of magnetic reconfiguration/reconnection due to generation, rather than annihilation, of magnetic field in a nun-uniform thin current sheet

NASA Astrophysics Data System (ADS)

Huang, Y. C.; Lyu, L. H.

2014-12-01

Magnetic reconfiguration/reconnection plays an important role on energy and plasma transport in the space plasma. It is known that magnetic field lines on two sides of a tangential discontinuity can connect to each other only at a neutral point, where the strength of the magnetic field is equal to zero. Thus, the standard reconnection picture with magnetic field lines intersecting at the neutral point is not applicable to the component reconnection events observed at the magnetopause and in the solar corona. In our early study (Yu, Lyu, & Wu, 2011), we have shown that annihilation of magnetic field near a thin current sheet can lead to the formation of normal magnetic field component (normal to the current sheet) to break the frozen-in condition and to accelerate the reconnected plasma flux, even without the presence of a neutral point. In this study, we examine whether or not a generation, rather than annihilation, of magnetic field in a nun-uniform thin current sheet can also lead to reconnection of plasma flux. Our results indicate that a non-uniform enhancement of electric current can yield formation of field-aligned currents. The normal-component magnetic field generated by the field-aligned currents can yield reconnection of plasma flux just outside the current-enhancement region. The particle motion that can lead to non-uniform enhancement of electric currents will be discussed.

Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus

PubMed Central

Liao, Hua-Xin; Lynch, Rebecca; Zhou, Tongqing; Gao, Feng; Alam, S. Munir; Boyd, Scott D.; Fire, Andrew Z.; Roskin, Krishna M.; Schramm, Chaim A.; Zhang, Zhenhai; Zhu, Jiang; Shapiro, Lawrence; Mullikin, James C.; Gnanakaran, S.; Hraber, Peter; Wiehe, Kevin; Kelsoe, Garnett; Yang, Guang; Xia, Shi-Mao; Montefiori, David C.; Parks, Robert; Lloyd, Krissey E.; Scearce, Richard M.; Soderberg, Kelly A.; Cohen, Myron; Kaminga, Gift; Louder, Mark K.; Tran, Lillan M.; Chen, Yue; Cai, Fangping; Chen, Sheri; Moquin, Stephanie; Du, Xiulian; Joyce, Gordon M.; Srivatsan, Sanjay; Zhang, Baoshan; Zheng, Anqi; Shaw, George M.; Hahn, Beatrice H.; Kepler, Thomas B.; Korber, Bette T.M.; Kwong, Peter D.; Mascola, John R.; Haynes, Barton F.

2013-01-01

Current HIV-1 vaccines elicit strain-specific neutralizing antibodies. However, cross-reactive neutralizing antibodies arise in ~20% of HIV-1-infected individuals, and details of their generation could provide a roadmap for effective vaccination. Here we report the isolation, evolution and structure of a broadly neutralizing antibody from an African donor followed from time of infection. The mature antibody, CH103, neutralized ~55% of HIV-1 isolates, and its co-crystal structure with gp120 revealed a novel loop-based mechanism of CD4-binding site recognition. Virus and antibody gene sequencing revealed concomitant virus evolution and antibody maturation. Notably, the CH103-lineage unmutated common ancestor avidly bound the transmitted/founder HIV-1 envelope glycoprotein, and evolution of antibody neutralization breadth was preceded by extensive viral diversification in and near the CH103 epitope. These data elucidate the viral and antibody evolution leading to induction of a lineage of HIV-1 broadly neutralizing antibodies and provide insights into strategies to elicit similar antibodies via vaccination. PMID:23552890

A magnetospheric magnetic field model with flexible current systems driven by independent physical parameters

NASA Technical Reports Server (NTRS)

Hilmer, Robert V.; Voigt, Gerd-Hannes

1995-01-01

A tilt-dependent magnetic field model of the Earth's magnetosphere with variable magnetopause standoff distance is presented. Flexible analytic representations for the ring and cross-tail currents, each composed of the elements derived from the Tsyganenko and Usmanov (1982) model, are combined with the fully shielded vacuum dipole configurations of Voigt (1981). Although the current sheet does not warp in the y-z plane, changes in the shape and position of the neutral sheet with dipole tilt are consistent with both MHD equilibrium theory and observations. In addition, there is good agreement with observed Delta B profiles and the average equatorial contours of magnetic field magnitude. While the dipole field is rigorously shielded within the defined magnetopause, the ring and cross-tails currents are not similarly confined, consequently, the model's region of validity is limited to the inner magnetosphere. The model depends on four independent external parameters. We present a simple but limited method of simulating several substorm related magnetic field changes associated with the disrupion of the near-Earth cross-tail current sheet and collapse of the midnight magnetotail field region. This feature further facilitates the generation of magnetic field configuration time sequences useful in plasma convection simulations of real magnetospheric events.

Cross-tail current - Resonant orbits

NASA Technical Reports Server (NTRS)

Kaufmann, Richard L.; Lu, Chen

1993-01-01

A technique to generate self-consistent 1D current sheets is described. Groups of monoenergetic protons were followed in a modified Harris magnetic field. This sample current sheet is characterized by resonant quasi-adiabatic orbits. The magnetic moment of a quasi-adiabatic ion which is injected from outside a current sheet changes substantially during the orbit but returns to almost its initial value by the time the ion leaves. Several ion and electron groups were combined to produce a plasma sheet in which the charged particles carry the currents needed to generate the magnetic field in which the orbits were traced. An electric field also is required to maintain charge neutrality. Three distinct orbit types, one involving untrapped ions and two composed of trapped ions, were identified. Limitations associated with the use of a 1D model also were investigated; it can provide a good physical picture of an important component of the cross-tail current, but cannot adequately describe any region of the magnetotail in which the principal current sheet is separated from the plasma sheet boundary layer by a nearly isotropic outer position of the central plasma sheet.

Recent advances in the characterization of HIV-1 neutralization assays for standardized evaluation of the antibody response to infection and vaccination.

PubMed

Polonis, Victoria R; Brown, Bruce K; Rosa Borges, Andrew; Zolla-Pazner, Susan; Dimitrov, Dimiter S; Zhang, Mei-Yun; Barnett, Susan W; Ruprecht, Ruth M; Scarlatti, Gabriella; Fenyö, Eva-Maria; Montefiori, David C; McCutchan, Francine E; Michael, Nelson L

2008-06-05

In AIDS vaccine development the pendulum has swung towards a renewed emphasis on the potential role for neutralizing antibodies in a successful global vaccine. It is recognized that vaccine-induced antibody performance, as assessed in the available neutralization assays, may well serve as a "gatekeeper" for HIV-1 subunit vaccine prioritization and advancement. As a result, development of a standardized platform for reproducible measurement of neutralizing antibodies has received considerable attention. Here we review current advancements in our knowledge of the performance of different types of antibodies in a traditional primary cell neutralization assay and the newer, more standardized TZM-bl reporter cell line assay. In light of recently revealed differences (see accompanying article) in the results obtained in these two neutralization formats, parallel evaluation with both platforms should be contemplated as an interim solution until a better understanding of immune correlates of protection is achieved.

Search for the Rare Decays $$B^{\\pm} \\to K^{\\pm} \\mu^+ \\mu^-$$ and $$B^0_d \\to K^* \\mu^+ \\mu^-$$

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wenger, Andreas

2009-01-01

The study of processes involving flavour-changing neutral currents provides a particularly promising probe for New Physics beyond the Standard Model of particle physics. These processes are forbidden at tree level and proceed through loop processes, which are strongly suppressed in the Standard Model. Cross-sections for these processes can be significantly enhanced by contributions from new particles as they are proposed in most extentions of the Standard Model. This thesis presents searches for two flavour-changing neutral current decays, B± ! K±μ+μ- and B0 d ! K¤μ+μ-. The analysis was performed on 4.1 fb-1 of data collected by the DØ detector inmore » Run II of the Fermilab Tevatron. Candidate events for the decay B± ! K±μ+μ- were selected using a multi-variate analysis technique and the number of signal events determined by a fit to the invariant mass spectrum. Normalising to the known branching fraction for B± ! J/ÃK±, a branching fraction of B(B± ! K± μ+μ-) = 6.45 ± 2.24 (stat) ± 1.19 (syst) × 10-7 (1) was measured. The branching fraction for the decay B0 d ! K¤μ+μ- was determined in a similar way. Normalizing to the known branching fraction for B0 d ! J/ÃK¤, a branching fraction of B(B0 d ! K¤ μ+μ-) = 11.15 ± 3.05 (stat) ± 1.94 (syst) × 10-7 (2) was measured. All measurements are in agreement with the Standard Model.« less

Search for active-sterile neutrino mixing using neutral-current interactions in NOvA

NASA Astrophysics Data System (ADS)

Adamson, P.; Aliaga, L.; Ambrose, D.; Anfimov, N.; Antoshkin, A.; Arrieta-Diaz, E.; Augsten, K.; Aurisano, A.; Backhouse, C.; Baird, M.; Bambah, B. A.; Bays, K.; Behera, B.; Bending, S.; Bernstein, R.; Bhatnagar, V.; Bhuyan, B.; Bian, J.; Blackburn, T.; Bolshakova, A.; Bromberg, C.; Brown, J.; Brunetti, G.; Buchanan, N.; Butkevich, A.; Bychkov, V.; Campbell, M.; Catano-Mur, E.; Childress, S.; Choudhary, B. C.; Chowdhury, B.; Coan, T. E.; Coelho, J. A. B.; Colo, M.; Cooper, J.; Corwin, L.; Cremonesi, L.; Cronin-Hennessy, D.; Davies, G. S.; Davies, J. P.; Derwent, P. F.; Dharmapalan, R.; Ding, P.; Djurcic, Z.; Dukes, E. C.; Duyang, H.; Edayath, S.; Ehrlich, R.; Feldman, G. J.; Frank, M. J.; Gabrielyan, M.; Gallagher, H. R.; Germani, S.; Ghosh, T.; Giri, A.; Gomes, R. A.; Goodman, M. C.; Grichine, V.; Groh, M.; Group, R.; Grover, D.; Guo, B.; Habig, A.; Hartnell, J.; Hatcher, R.; Hatzikoutelis, A.; Heller, K.; Himmel, A.; Holin, A.; Howard, B.; Hylen, J.; Jediny, F.; Judah, M.; Kafka, G. K.; Kalra, D.; Kasahara, S. M. S.; Kasetti, S.; Keloth, R.; Kolupaeva, L.; Kotelnikov, S.; Kourbanis, I.; Kreymer, A.; Kumar, A.; Kurbanov, S.; Lackey, T.; Lang, K.; Lee, W. M.; Lin, S.; Lokajicek, M.; Lozier, J.; Luchuk, S.; Maan, K.; Magill, S.; Mann, W. A.; Marshak, M. L.; Matera, K.; Matveev, V.; Méndez, D. P.; Messier, M. D.; Meyer, H.; Miao, T.; Miller, W. H.; Mishra, S. R.; Mohanta, R.; Moren, A.; Mualem, L.; Muether, M.; Mufson, S.; Murphy, R.; Musser, J.; Nelson, J. K.; Nichol, R.; Niner, E.; Norman, A.; Nosek, T.; Oksuzian, Y.; Olshevskiy, A.; Olson, T.; Paley, J.; Patterson, R. B.; Pawloski, G.; Pershey, D.; Petrova, O.; Petti, R.; Phan-Budd, S.; Plunkett, R. K.; Poling, R.; Potukuchi, B.; Principato, C.; Psihas, F.; Radovic, A.; Rameika, R. A.; Rebel, B.; Reed, B.; Rocco, D.; Rojas, P.; Ryabov, V.; Sachdev, K.; Sail, P.; Samoylov, O.; Sanchez, M. C.; Schroeter, R.; Sepulveda-Quiroz, J.; Shanahan, P.; Sheshukov, A.; Singh, J.; Singh, J.; Singh, P.; Singh, V.; Smolik, J.; Solomey, N.; Song, E.; Sousa, A.; Soustruznik, K.; Strait, M.; Suter, L.; Talaga, R. L.; Tas, P.; Thayyullathil, R. B.; Thomas, J.; Tian, X.; Tognini, S. C.; Tripathi, J.; Tsaris, A.; Urheim, J.; Vahle, P.; Vasel, J.; Vinton, L.; Vold, A.; Vrba, T.; Wang, B.; Wetstein, M.; Whittington, D.; Wojcicki, S. G.; Wolcott, J.; Yadav, N.; Yang, S.; Zalesak, J.; Zamorano, B.; Zwaska, R.; NOvA Collaboration

2017-10-01

We report results from the first search for sterile neutrinos mixing with active neutrinos through a reduction in the rate of neutral-current interactions over a baseline of 810 km between the NOvA detectors. Analyzing a 14-kton detector equivalent exposure of 6.05 ×1020 protons-on-target in the NuMI beam at Fermilab, we observe 95 neutral-current candidates at the Far Detector compared with 83.5 ±9.7 (stat ) ±9.4 (syst ) events predicted assuming mixing only occurs between active neutrino species. No evidence for νμ→νs transitions is found. Interpreting these results within a 3 +1 model, we place constraints on the mixing angles θ24<20.8 ° and θ34<31.2 ° at the 90% C.L. for 0.05 eV2≤Δ m412≤0.5 eV2 , the range of mass splittings that produce no significant oscillations over the Near Detector baseline.

Exploring Nucleon Spin Structure Through Neutrino Neutral-Current Interactions in MicroBooNE

DOE Office of Scientific and Technical Information (OSTI.GOV)

Woodruff, Katherine

2017-02-02

The net contribution of the strange quark spins to the proton spin,more » $$\\Delta s$$, can be determined from neutral current elastic neutrino-proton interactions at low momentum transfer combined with data from electron-proton scattering. The probability of neutrino-proton interactions depends in part on the axial form factor, which represents the spin structure of the proton and can be separated into its quark flavor contributions. Low momentum transfer neutrino neutral current interactions can be measured in MicroBooNE, a high-resolution liquid argon time projection chamber (LArTPC) in its first year of running in the Booster Neutrino Beamline at Fermilab. The signal for these interactions in MicroBooNE is a single short proton track. We present our work on the automated reconstruction and classification of proton tracks in LArTPCs, an important step in the determination of neutrino- nucleon cross sections and the measurement of $$\\Delta s$$.« less

Development of a high current 60 keV neutral lithium beam injector for beam emission spectroscopy measurements on fusion experiments.

PubMed

Anda, G; Dunai, D; Lampert, M; Krizsanóczi, T; Németh, J; Bató, S; Nam, Y U; Hu, G H; Zoletnik, S

2018-01-01

A 60 keV neutral lithium beam system was designed and built up for beam emission spectroscopy measurement of edge plasma on the KSTAR and EAST tokamaks. The electron density profile and its fluctuation can be measured using the accelerated lithium beam-based emission spectroscopy system. A thermionic ion source was developed with a SiC heater to emit around 4-5 mA ion current from a 14 mm diameter surface. The ion optic is following the 2 step design used on other devices with small modifications to reach about 2-3 cm beam diameter in the plasma at about 4 m from the ion source. A newly developed recirculating sodium vapour neutralizer neutralizes the accelerated ion beam at around 260-280 °C even during long (<20 s) discharges. A set of new beam diagnostic and manipulation techniques are applied to allow optimization, aiming, cleaning, and beam modulation. The maximum 60 keV beam energy with 4 mA ion current was successfully reached at KSTAR and at EAST. Combined with an efficient observation system, the Li-beam diagnostic enables the measurement of the density profile and fluctuations on the plasma turbulence time scale.

Development of a high current 60 keV neutral lithium beam injector for beam emission spectroscopy measurements on fusion experiments

NASA Astrophysics Data System (ADS)

Anda, G.; Dunai, D.; Lampert, M.; Krizsanóczi, T.; Németh, J.; Bató, S.; Nam, Y. U.; Hu, G. H.; Zoletnik, S.

2018-01-01

A 60 keV neutral lithium beam system was designed and built up for beam emission spectroscopy measurement of edge plasma on the KSTAR and EAST tokamaks. The electron density profile and its fluctuation can be measured using the accelerated lithium beam-based emission spectroscopy system. A thermionic ion source was developed with a SiC heater to emit around 4-5 mA ion current from a 14 mm diameter surface. The ion optic is following the 2 step design used on other devices with small modifications to reach about 2-3 cm beam diameter in the plasma at about 4 m from the ion source. A newly developed recirculating sodium vapour neutralizer neutralizes the accelerated ion beam at around 260-280 °C even during long (<20 s) discharges. A set of new beam diagnostic and manipulation techniques are applied to allow optimization, aiming, cleaning, and beam modulation. The maximum 60 keV beam energy with 4 mA ion current was successfully reached at KSTAR and at EAST. Combined with an efficient observation system, the Li-beam diagnostic enables the measurement of the density profile and fluctuations on the plasma turbulence time scale.

Stress improves selective attention towards emotionally neutral left ear stimuli.

PubMed

Hoskin, Robert; Hunter, M D; Woodruff, P W R

2014-09-01

Research concerning the impact of psychological stress on visual selective attention has produced mixed results. The current paper describes two experiments which utilise a novel auditory oddball paradigm to test the impact of psychological stress on auditory selective attention. Participants had to report the location of emotionally-neutral auditory stimuli, while ignoring task-irrelevant changes in their content. The results of the first experiment, in which speech stimuli were presented, suggested that stress improves the ability to selectively attend to left, but not right ear stimuli. When this experiment was repeated using tonal stimuli the same result was evident, but only for female participants. Females were also found to experience greater levels of distraction in general across the two experiments. These findings support the goal-shielding theory which suggests that stress improves selective attention by reducing the attentional resources available to process task-irrelevant information. The study also demonstrates, for the first time, that this goal-shielding effect extends to auditory perception. Copyright © 2014 Elsevier B.V. All rights reserved.

Campus Climate Neutrality--Yes We Can! It's a Big Challenge, but Here's How to Do It

ERIC Educational Resources Information Center

Simpson, Walter

2009-01-01

Everyone knows climate change is real, it's happening quickly, its risks are great, and it is not too late to do something about it. Indicative of change is the fact that as of early 2009 over 600 colleges and universities have pledged to achieve climate neutrality through the American College & University Presidents Climate Commitment. Presidents…

Inductively generated streaming plasma ion source

DOEpatents

Glidden, Steven C.; Sanders, Howard D.; Greenly, John B.

2006-07-25

A novel pulsed, neutralized ion beam source is provided. The source uses pulsed inductive breakdown of neutral gas, and magnetic acceleration and control of the resulting plasma, to form a beam. The beam supplies ions for applications requiring excellent control of ion species, low remittance, high current density, and spatial uniformity.

Spatial calibration of a tokamak neutral beam diagnostic using in situ neutral beam emission

DOE PAGES

Chrystal, Colin; Burrell, Keith H.; Grierson, Brian A.; ...

2015-10-20

Neutral beam injection is used in tokamaks to heat, apply torque, drive non-inductive current, and diagnose plasmas. Neutral beam diagnostics need accurate spatial calibrations to benefit from the measurement localization provided by the neutral beam. A new technique has been developed that uses in-situ measurements of neutral beam emission to determine the spatial location of the beam and the associated diagnostic views. This technique was developed to improve the charge exchange recombination diagnostic (CER) at the DIII-D tokamak and uses measurements of the Doppler shift and Stark splitting of neutral beam emission made by that diagnostic. These measurements contain informationmore » about the geometric relation between the diagnostic views and the neutral beams when they are injecting power. This information is combined with standard spatial calibration measurements to create an integrated spatial calibration that provides a more complete description of the neutral beam-CER system. The integrated spatial calibration results are very similar to the standard calibration results and derived quantities from CER measurements are unchanged within their measurement errors. Lastly, the methods developed to perform the integrated spatial calibration could be useful for tokamaks with limited physical access.« less

Spatial calibration of a tokamak neutral beam diagnostic using in situ neutral beam emission

NASA Astrophysics Data System (ADS)

Chrystal, C.; Burrell, K. H.; Grierson, B. A.; Pace, D. C.

2015-10-01

Neutral beam injection is used in tokamaks to heat, apply torque, drive non-inductive current, and diagnose plasmas. Neutral beam diagnostics need accurate spatial calibrations to benefit from the measurement localization provided by the neutral beam. A new technique has been developed that uses in situ measurements of neutral beam emission to determine the spatial location of the beam and the associated diagnostic views. This technique was developed to improve the charge exchange recombination (CER) diagnostic at the DIII-D tokamak and uses measurements of the Doppler shift and Stark splitting of neutral beam emission made by that diagnostic. These measurements contain information about the geometric relation between the diagnostic views and the neutral beams when they are injecting power. This information is combined with standard spatial calibration measurements to create an integrated spatial calibration that provides a more complete description of the neutral beam-CER system. The integrated spatial calibration results are very similar to the standard calibration results and derived quantities from CER measurements are unchanged within their measurement errors. The methods developed to perform the integrated spatial calibration could be useful for tokamaks with limited physical access.

Filamentation instability of a fast electron beam in a dielectric target.

PubMed

Debayle, A; Tikhonchuk, V T

2008-12-01

High-intensity laser-matter interaction is an efficient method for high-current relativistic electron beam production. At current densities exceeding a several kA microm{-2} , the beam propagation is maintained by an almost complete current neutralization by the target electrons. In such a geometry of two oppositely directed flows, beam instabilities can develop, depending on the target and the beam parameters. The present paper proposes an analytical description of the filamentation instability of an electron beam propagating through an insulator target. It is shown that the collisionless and resistive instabilities enter into competition with the ionization instability. This latter process is dominant in insulator targets where the field ionization by the fast beam provides free electrons for the neutralization current.

Measurement of the ratios of neutral-current to charged current cross sections of neutrino and antineutrino interactions in Ne

NASA Astrophysics Data System (ADS)

Bosetti, P. C.; Fritze, P.; Grässler, H.; Hasert, F. J.; Schulte, R.; Schultze, K.; Geich-Gimbel, C.; Nellen, B.; Pech, R.; Wünsch, B.; Grant, A.; Hulth, P. O.; Klein, H.; Morrison, D. R. O.; Pape, L.; Wachsmuth, H.; Vayaki, A.; Barnham, K. W. J.; Beuselinck, R.; Clayton, E. F.; Miller, D. B.; Mobayyen, M. M.; Petrides, A.; Albajar, C.; Myatt, G.; Saitta, B.; Wells, J.; Bolognese, T.; Vignaud, D.; Aachen-Bonn-CERN-Democritos-Imperial College, London-Oxford-Saclay Collaboration

1983-05-01

The ratios of neutral current to charged current cross sections of neutrino and antineutrino interactions in heavy Ne/H 2 mixture have been measured in BEBC. The beam was the CERN SPS 200 GeV/ c narrow band beam. The ratios were obtained using a cut in the transverse momentum of the hadronic system. In the standard Glashow-Salam-Weinberg model, our results correspond to the value of sin 2θw = 0.182 ± 0.020 ± 0.012. By combining this experiment with data from a hydrogen target the coupling constants uL2 and L2 are found to be 0.15 ± 0.04 and 0.19 ± 0.05, respectively.

An appetitive conditioned stimulus enhances fear acquisition and impairs fear extinction

PubMed Central

Leung, Hiu T.; Holmes, Nathan M.

2016-01-01

Four experiments used between- and within-subject designs to examine appetitive–aversive interactions in rats. Experiments 1 and 2 examined the effect of an excitatory appetitive conditioned stimulus (CS) on acquisition and extinction of conditioned fear. In Experiment 1, a CS shocked in a compound with an appetitive excitor (i.e., a stimulus previously paired with sucrose) underwent greater fear conditioning than a CS shocked in a compound with a neutral stimulus. Conversely, in Experiment 2, a CS extinguished in a compound with an appetitive excitor underwent less extinction than a CS extinguished in a compound with a neutral stimulus. Experiments 3 and 4 compared the amount of fear conditioning to an appetitive excitor and a familiar but neutral target CS when the compound of these stimuli was paired with shock. In each experiment, more fear accrued to the appetitive excitor than to the neutral CS. These results show that an appetitive excitor influences acquisition and extinction of conditioned fear to a neutral CS and itself undergoes a greater associative change than the neutral CS across compound conditioning. They are discussed with respect to the role of motivational information in regulating an associative change in appetitive–aversive interactions. PMID:26884229

Strong electromagnetic pulses generated in high-intensity short-pulse laser interactions with thin foil targets

NASA Astrophysics Data System (ADS)

Rączka, P.; Dubois, J.-L.; Hulin, S.; Tikhonchuk, V.; Rosiński, M.; Zaraś-Szydłowska, A.; Badziak, J.

2017-12-01

Measurements are reported of the target neutralization current, the target charge, and the tangential component of the magnetic field generated as a result of laser-target interaction by pulses with the energy in the range of 45 mJ to 92 mJ on target and the pulse duration from 39 fs to 1000 fs. The experiment was performed at the Eclipse facility in CELIA, Bordeaux. The aim of the experiment was to extend investigations performed for the thick (mm scale) targets to the case of thin (micrometer thickness) targets in a way that would allow for a straightforward comparison of the results. We found that thin foil targets tend to generate 20 to 50 percent higher neutralization current and the target charge than the thick targets. The measurement of the tangential component of the magnetic field had shown that the initial spike is dominated by the 1 ns pulse consistent with the 1 ns pulse of the neutralization current, but there are some differences between targets of different type on sub-ns scale, which is an effect going beyond a simple picture of the target acting as an antenna. The sub-ns structure appears to be reproducible to surprising degree. We found that there is in general a linear correlation between the maximum value of the magnetic field and the maximum neutralization current, which supports the target-antenna picture, except for pulses hundreds of fs long.

Incorporation of alpha-Ketoglutaric Acid as a Fixed Bed Scrubber Media for the Neutralization of Hydrazine Family Hypergolic Fuels

NASA Technical Reports Server (NTRS)

DeVor, R. W.; Santiago-Maldonado, E.; Parkerson, J. K.

2010-01-01

A candidate scrubber media, alpha-ketoglutaric acid (aKGA) adsorbed onto a silica-based substrate was examined as a potential alternative to the hydrazine-family hypergolic fuel neutralization techniques currently utilized at NASA/Kennedy Space Center (KSC). Helvenson et. al. has indicated that aKGA will react with hydrazines to produce non-hazardous, possibly biodegradable products. Furthermore, the authors have previously tested and demonstrated the use of aKGA aqueous solutions as a replacement neutralizing agent for citric acid, which is currently used as a scrubbing agent in liquid scrubbers at KSC. Specific properties examined include reaction efficiency, the loading capacity of aKGA onto various silica substrates, and the comparison of aKGA media performance to that of the citric acid vapor scrubber systems at KSC and a commercial vapor scrubber media. Preliminary investigations showed hydrophobic aerogel particles to be an ideal substrate for the deposition of the aKGA. Current studies have shown that the laboratory produced aKGA-Aerogel absorbent media are more efficient and cost effective than a commercially available fixed bed scrubber media, although much less cost effective than liquid-based citric acid scrubbers (although possibly safer and less labor intensive). A comparison of all three alternative scrubber technologies (liquid aKGA, solid-phase aKGA, and commercially available sorbent materials) is given considering both hypergolic neutralization capabilities and relative costs (as compared to the current citric acid scrubbing technology in use at NASA/KSC).

Development and characterization of minoxidil-loaded liposomal system for delivery to pilosebaceous units.

PubMed

Jain, Bhawna; Singh, Bhupinder; Katare, Om Prakash; Vyas, Suresh Prashad

2010-06-01

The current study aimed to deliver minoxidil (2,4-diamino-6-piperidinopyrimidine 3-oxide; MXD), a potent hypertrichotic agent, into the pilosebaceous units, exploring the potential of the liposomal system. MXD-loaded liposomes of different compositions were prepared by a thin-film hydration technique and subsequently characterized for various vesicle-specific attributes (i.e., size, shape, lamellarity, and entrapment efficiency). Comparative analysis among these compositions was conducted with reference to their vesicle-specific parameters, drug deposition, and drug-delivery mechanism toward pilosebaceous units. The latter may bring about a distinct change in MXD therapy for various ailments related to pilosebaceous units, such as alopecia. The in vitro drug release, ex vivo skin permeation, and drug-retention behavior of the prepared formulation were evaluated by employing rat skin (normal as well as pilosebaceous free) and semipermeable membrane. The results revealed that the neutral liposomes (mean vesicle size, 3.83 +/- 0.18 microm) showed maximum drug deposition in the pilosebaceous units among all the other tested formulations. A quantitative estimation of pilosebaceous delivery revealed that the concentration of MXD in each pilosebaceous unit decreased in the following order: neutral liposomal formulation (5.8 x 10(3) to 7.25 x 10(3) microg) > positively charged liposomal formulation (4.7 x 10(3) to 5.87 x 10(3) microg) > negatively charged liposomal formulation (4.2 x 10(3) to 5.25 x 10(3) microg) > nonliposomal formulation (1.6 x 10(3) to 2.0 x 10(3) microg). Stability studies construed the need to store the liposomal formulation at lower temperatures. The results of the current work indicate that the neutral liposomes can deliver the drug molecules into pilosebaceous units more effectively than the other studied formulations.

SOURCES AND SINKS OF NEUTRALS AND PLASMA IN THE SATURNIAN MAGNETOSPHERE (Invited)

NASA Astrophysics Data System (ADS)

Richardson, J. D.

2009-12-01

This talk will review current knowledge on the source and sinks of plasm and energy in Saturn's magnetosphere. Enceladus dominates the water group source, with most of the material escaping from the plume near the southern pole. The relatively low corotation energy in this region results in less energy being available to heat electrons. The electrons are too cold to ionize the neutrals and the inner magnetosphere is dominated by neutrals. In addition, Saturn's atmosphere is a large source of neutral H, the rings contribute O2, and Titan is a source whose magnitude is controversial. In the inner magnetosphere most particles and energy are removed as fast neutrals; transport is more important further out and may be dominated by fingers of inflow and outflow as at Jupiter.

Magnetic Reconnection in Strongly Magnetized Regions of the Low Solar Chromosphere

NASA Astrophysics Data System (ADS)

Ni, Lei; Lukin, Vyacheslav S.; Murphy, Nicholas A.; Lin, Jun

2018-01-01

Magnetic reconnection in strongly magnetized regions around the temperature minimum region of the low solar atmosphere is studied by employing MHD-based simulations of a partially ionized plasma within a reactive 2.5D multi-fluid model. It is shown that in the absence of magnetic nulls in a low β plasma, the ionized and neutral fluid flows are well-coupled throughout the reconnection region. However, non-equilibrium ionization–recombination dynamics play a critical role in determining the structure of the reconnection region, leading to much lower temperature increases and a faster magnetic reconnection rate as compared to simulations that assume plasma to be in ionization–recombination equilibrium. The rate of ionization of the neutral component of the plasma is always faster than recombination within the current sheet region even when the initial plasma β is as high as {β }0=1.46. When the reconnecting magnetic field is in excess of a kilogauss and the plasma β is lower than 0.0145, the initially weakly ionized plasmas can become fully ionized within the reconnection region and the current sheet can be strongly heated to above 2.5× {10}4 K, even as most of the collisionally dissipated magnetic energy is radiated away. The Hall effect increases the reconnection rate slightly, but in the absence of magnetic nulls it does not result in significant asymmetries or change the characteristics of the reconnection current sheet down to meter scales.

Death Attitudes and Changes in Existential Outlook in Parents of Vulnerable Newborns.

PubMed

Barr, Peter

2015-01-01

This study is an Actor-Partner Interdependence Model analysis of the relation of death attitudes with changes in outlook in 59 parent couples of neonatal intensive care newborns. Death attitudes effects with changes in outlook were mostly intrapersonal and they mainly occurred in fathers, though between gender differences were not usually significant. Death avoidance and neutral death acquiescence were positive predictors of positive changes in outlook, and fear of death and neutral death acquiescence were respective positive and inverse predictors of negative changes. Multidimensional measures of death attitudes and personal change should be used when studying these domains of psychological functioning.

A numerical study of neutral-plasma interaction in magnetically confined plasmas

NASA Astrophysics Data System (ADS)

Taheri, S.; Shumlak, U.; King, J. R.

2017-10-01

Interactions between plasma and neutral species can have a large effect on the dynamic behavior of magnetically confined plasma devices, such as the edge region of tokamaks and the plasma formation of Z-pinches. The presence of neutrals can affect the stability of the pinch and change the dynamics of the pinch collapse, and they can lead to deposition of high energy particles on the first wall. However, plasma-neutral interactions can also have beneficial effects such as quenching the disruptions in tokamaks. In this research a reacting plasma-neutral model, which combines a magnetohydrodynamic (MHD) plasma model with a gas dynamic neutral fluid model, is used to study the interaction between plasma and neutral gas. Incorporating this model into NIMROD allows the study of electron-impact ionization, radiative recombination, and resonant charge-exchange in plasma-neutral systems. An accelerated plasma moving through a neutral gas background is modeled in both a parallel plate and a coaxial electrode configuration to explore the effect of neutral gas in pinch-like devices. This work is supported by a Grant from US DOE.

ELM-free and inter-ELM divertor heat flux broadening induced by edge harmonics oscillation in NSTX

DOE PAGES

Gan, K. F.; Ahn, J. -W.; Gray, T. K.; ...

2017-10-26

A new n =1 dominated edge harmonic oscillation (EHO) has been found in NSTX. The new EHO, rotating toroidally in the counter-current direction and the opposite direction of the neutral beam, was observed during certain inter-ELM and ELM-free periods of H-mode operation. This EHO is associated with a significant broadening of the integral heat flux width (more » $${{\\lambda}_{\\operatorname{int}}}$$ ) by up to 150%, and a decrease in the divertor peak heat flux by >60%. An EHO induced filament was also observed by the gas puff imaging diagnostic. The toroidal rotating filaments could change the edge magnetic topology resulting in toroidal rotating strike point splitting and heat flux broadening. Finally, experimental result of the counter current rotation of strike points splitting is consistent with the counter-current EHO.« less

The cold driver: Cold stress while driving results in dangerous behavior.

PubMed

Morris, Drew M; Pilcher, June J

2016-10-01

Cool vehicle cabin temperatures can induce short-term non-hypothermic cold stress. The current study created a cold condition to examine the impact of cold stress on driving behavior. Forty-four participants drove a high-fidelity driving simulator during a thermal neutral or local torso cooled condition. Participants performed additional tasks to assess attention, psychomotor vigilance, and manual dexterity. Skin temperature was significantly lower in the cold condition while internal temperature was unaffected. Participants who had higher subjective ratings of cold followed lead vehicles closer and started to brake later. Participants in the cold condition followed the lead car 22% (0.82s) closer and started braking 20% (2.35s) later when approaching a stop sign during the car-following task. No change in attention, psychomotor vigilance, or dexterity was observed. The current results suggest that cold environmental conditions can contribute to dangerous driving behaviors. Measures of cold perception were also shown to predict changes in driving behavior. Copyright © 2016 Elsevier B.V. All rights reserved.

Indirect handle on the down-quark Yukawa coupling.

PubMed

Goertz, Florian

2014-12-31

To measure the Yukawa couplings of the up and down quarks, Yu,d, seems to be far beyond the capabilities of current and (near) future experiments in particle physics. By performing a general analysis of the potential misalignment between quark masses and Yukawa couplings, we derive predictions for the magnitude of induced flavor-changing neutral currents (FCNCs), depending on the shift in the physical Yukawa coupling of first-generation quarks. We find that a change of more than 50% in Yd would generically result in ds transitions in conflict with kaon physics. This could already be seen as evidence for a nonvanishing direct coupling of the down quark to the newly discovered Higgs boson. The nonobservation of certain--already well-constrained--processes is thus turned into a powerful indirect measure of otherwise basically unaccessible physical parameters of the effective standard model. Similarly, improvements in limits on FCNCs in the up-type quark sector can lead to valuable information on Yu.

Two-fluid (plasma-neutral) Extended-MHD simulations of spheromak configurations in the HIT-SI experiment with PSI-Tet

NASA Astrophysics Data System (ADS)

Sutherland, D. A.; Hansen, C. J.; Jarboe, T. R.

2017-10-01

A self-consistent, two-fluid (plasma-neutral) dynamic neutral model has been implemented into the 3-D, Extended-MHD code PSI-Tet. A monatomic, hydrogenic neutral fluid reacts with a plasma fluid through elastic scattering collisions and three inelastic collision reactions: electron-impact ionization, radiative recombination, and resonant charge-exchange. Density, momentum, and energy are evolved for both the plasma and neutral species. The implemented plasma-neutral model in PSI-Tet is being used to simulate decaying spheromak configurations in the HIT-SI experimental geometry, which is being compare to two-photon absorption laser induced fluorescence measurements (TALIF) made on the HIT-SI3 experiment. TALIF is used to measure the absolute density and temperature of monatomic deuterium atoms. Neutral densities on the order of 1015 m-3 and neutral temperatures between 0.6-1.7 eV were measured towards the end of decay of spheromak configurations with initial toroidal currents between 10-12 kA. Validation results between TALIF measurements and PSI-Tet simulations with the implemented dynamic neutral model will be presented. Additionally, preliminary dynamic neutral simulations of the HIT-SI/HIT-SI3 spheromak plasmas sustained with inductive helicity injection will be presented. Lastly, potential benefits of an expansion of the two-fluid model into a multi-fluid model that includes multiple neutral species and tracking of charge states will be discussed.

Reverse current in solar flares

NASA Technical Reports Server (NTRS)

Knight, J. W.; Sturrock, P. A.

1977-01-01

We examine the proposal that impulsive X-ray bursts are produced by high-energy electrons streaming from the corona to the chromosphere. It is known that the currents associated with these streams are so high that either the streams do not exist or their current is neutralized by a reverse current. Analysis of a simple model in which the reverse current is stable indicates that the primary electron stream leads to the development of an electric field in the ambient corona which (a) decelerates the primary beam and (b) produces a neutralizing reverse current. It appears that, in some circumstances, this electric field could prevent the primary beam from reaching the chromosphere. In any case, the electric field acts as an energy exchange mechanism, extracting kinetic energy from the primary beam and using it to heat the ambient plasma. This heating is typically so rapid that it must be expected to have important dynamical consequences.

Performance of Four-Leg VSC based DSTATCOM using Single Phase P-Q Theory

NASA Astrophysics Data System (ADS)

Jampana, Bangarraju; Veramalla, Rajagopal; Askani, Jayalaxmi

2017-02-01

This paper presents single-phase P-Q theory for four-leg VSC based distributed static compensator (DSTATCOM) in the distribution system. The proposed DSTATCOM maintains unity power factor at source, zero voltage regulation, eliminates current harmonics, load balancing and neutral current compensation. The advantage of using four-leg VSC based DSTATCOM is to eliminate isolated/non-isolated transformer connection at point of common coupling (PCC) for neutral current compensation. The elimination of transformer connection at PCC with proposed topology will reduce cost of DSTATCOM. The single-phase P-Q theory control algorithm is used to extract fundamental component of active and reactive currents for generation of reference source currents which is based on indirect current control method. The proposed DSTATCOM is modelled and the results are validated with various consumer loads under unity power factor and zero voltage regulation modes in the MATLAB R2013a environment using simpower system toolbox.

Distribution of E/N and N/e/ in a cross-flow electric discharge laser. [electric field to neutral gas density and electron number density

NASA Technical Reports Server (NTRS)

Dunning, J. W., Jr.; Lancashire, R. B.; Manista, E. J.

1976-01-01

Measurements have been conducted of the effect of the convection of ions and electrons on the discharge characteristics in a large scale laser. The results are presented for one particular distribution of ballast resistance. Values of electric field, current density, input power density, ratio of electric field to neutral gas density (E/N), and electron number density were calculated on the basis of measurements of the discharge properties. In a number of graphs, the E/N ratio, current density, power density, and electron density are plotted as a function of row number (downstream position) with total discharge current and gas velocity as parameters. From the dependence of the current distribution on the total current, it appears that the electron production in the first two rows significantly affects the current flowing in the succeeding rows.

Capturing neutral and adaptive genetic diversity for conservation in a highly structured tree species.

PubMed

Rodríguez-Quilón, Isabel; Santos-Del-Blanco, Luis; Serra-Varela, María Jesús; Koskela, Jarkko; González-Martínez, Santiago C; Alía, Ricardo

2016-10-01

Preserving intraspecific genetic diversity is essential for long-term forest sustainability in a climate change scenario. Despite that, genetic information is largely neglected in conservation planning, and how conservation units should be defined is still heatedly debated. Here, we use maritime pine (Pinus pinaster Ait.), an outcrossing long-lived tree with a highly fragmented distribution in the Mediterranean biodiversity hotspot, to prove the importance of accounting for genetic variation, of both neutral molecular markers and quantitative traits, to define useful conservation units. Six gene pools associated to distinct evolutionary histories were identified within the species using 12 microsatellites and 266 single nucleotide polymorphisms (SNPs). In addition, height and survival standing variation, their genetic control, and plasticity were assessed in a multisite clonal common garden experiment (16 544 trees). We found high levels of quantitative genetic differentiation within previously defined neutral gene pools. Subsequent cluster analysis and post hoc trait distribution comparisons allowed us to define 10 genetically homogeneous population groups with high evolutionary potential. They constitute the minimum number of units to be represented in a maritime pine dynamic conservation program. Our results uphold that the identification of conservation units below the species level should account for key neutral and adaptive components of genetic diversity, especially in species with strong population structure and complex evolutionary histories. The environmental zonation approach currently used by the pan-European genetic conservation strategy for forest trees would be largely improved by gradually integrating molecular and quantitative trait information, as data become available. © 2016 by the Ecological Society of America.

Dynamic neutral beam current and voltage control to improve beam efficacy in tokamaks

NASA Astrophysics Data System (ADS)

Pace, D. C.; Austin, M. E.; Bardoczi, L.; Collins, C. S.; Crowley, B.; Davis, E.; Du, X.; Ferron, J.; Grierson, B. A.; Heidbrink, W. W.; Holcomb, C. T.; McKee, G. R.; Pawley, C.; Petty, C. C.; Podestà, M.; Rauch, J.; Scoville, J. T.; Spong, D. A.; Thome, K. E.; Van Zeeland, M. A.; Varela, J.; Victor, B.

2018-05-01

An engineering upgrade to the neutral beam system at the DIII-D tokamak [J. L. Luxon, Nucl. Fusion 42, 614 (2002)] enables time-dependent programming of the beam voltage and current. Initial application of this capability involves pre-programmed beam voltage and current injected into plasmas that are known to be susceptible to instabilities that are driven by energetic ( E ≥ 40 keV) beam ions. These instabilities, here all Alfvén eigenmodes (AEs), increase the transport of the beam ions beyond a classical expectation based on particle drifts and collisions. Injecting neutral beam power, P beam ≥ 2 MW, at reduced voltage with increased current reduces the drive for Alfvénic instabilities and results in improved ion confinement. In lower-confinement plasmas, this technique is applied to eliminate the presence of AEs across the mid-radius of the plasmas. Simulations of those plasmas indicate that the mode drive is decreased and the radial extent of the remaining modes is reduced compared to a higher beam voltage case. In higher-confinement plasmas, this technique reduces AE activity in the far edge and results in an interesting scenario of beam current drive improving as the beam voltage reduces from 80 kV to 65 kV.

Dynamic neutral beam current and voltage control to improve beam efficacy in tokamaks

DOE Office of Scientific and Technical Information (OSTI.GOV)

Austin, Max E.; Bardoczi, Laszlo; Collins, Cami S.

Here, an engineering upgrade to the neutral beam system at the DIII-D tokamak enables time-dependent programming of the beam voltage and current. Initial application of this capability involves pre-programmed beam voltage and current injected into plasmas that are known to be susceptible to instabilities that are driven by energetic (E ≥ 40 keV) beam ions. These instabilities, here all Alfvén eigenmodes (AEs), increase the transport of the beam ions beyond a classical expectation based on particle drifts and collisions. Injecting neutral beam power, P beam ≥ 2MW, at reduced voltage with increased current reduces the drive for Alfvénic instabilities andmore » results in improved ion confinement. In lower-confinement plasmas, this technique is applied to eliminate the presence of AEs across the mid-radius of the plasmas. Simulations of those plasmas indicate that the mode drive is decreased and the radial extent of the remaining modes is reduced compared to a higher beam voltage case. In higher-confinement plasmas, this technique reduces AE activity in the far edge and results in an interesting scenario of beam current drive improving as the beam voltage reduces from 80 kV to 65 kV.« less

Dynamic neutral beam current and voltage control to improve beam efficacy in tokamaks

DOE PAGES

Austin, Max E.; Bardoczi, Laszlo; Collins, Cami S.; ...

2018-04-20

Here, an engineering upgrade to the neutral beam system at the DIII-D tokamak enables time-dependent programming of the beam voltage and current. Initial application of this capability involves pre-programmed beam voltage and current injected into plasmas that are known to be susceptible to instabilities that are driven by energetic (E ≥ 40 keV) beam ions. These instabilities, here all Alfvén eigenmodes (AEs), increase the transport of the beam ions beyond a classical expectation based on particle drifts and collisions. Injecting neutral beam power, P beam ≥ 2MW, at reduced voltage with increased current reduces the drive for Alfvénic instabilities andmore » results in improved ion confinement. In lower-confinement plasmas, this technique is applied to eliminate the presence of AEs across the mid-radius of the plasmas. Simulations of those plasmas indicate that the mode drive is decreased and the radial extent of the remaining modes is reduced compared to a higher beam voltage case. In higher-confinement plasmas, this technique reduces AE activity in the far edge and results in an interesting scenario of beam current drive improving as the beam voltage reduces from 80 kV to 65 kV.« less

Identification of pleasant, neutral, and unpleasant odors in schizophrenia.

PubMed

Kamath, Vidyulata; Turetsky, Bruce I; Moberg, Paul J

2011-05-15

Recent work on odor hedonics in schizophrenia has indicated that patients display abnormalities in hedonic judgments of odors in comparison to healthy comparison participants. In the current study, identification accuracy for pleasant, neutral, and unpleasant odors in individuals with schizophrenia and healthy controls was examined. Thirty-three schizophrenia patients (63% male) and thirty-one healthy volunteers (65% male) were recruited. The groups were well matched on age, sex, and smoking status. Participants were administered the University of Pennsylvania Smell Identification Test, which was subsequently divided into 16 pleasant, 15 neutral, and 9 unpleasant items. Analysis of identification z-scores for pleasant, neutral, and unpleasant odors revealed a significant diagnosis by valence interaction. Post-hoc analysis revealed that schizophrenia participants made more identification errors on pleasant and neutral odors compared to healthy controls, with no differences observed for unpleasant odors. No effect was seen for sex. The findings from the current investigation suggest that odor identification accuracy in patients is influenced by odor valence. This pattern of results parallels a growing body of literature indicating that patients display aberrant pleasantness ratings for pleasant odors and highlights the need for additional research on the influence of odor valence on olfactory identification performance in individuals with schizophrenia. Copyright © 2010 Elsevier Ltd. All rights reserved.

Ferroelectric Plasma Sources for Ion Beam Neutralization

NASA Astrophysics Data System (ADS)

Stepanov, A.; Gilson, E. P.; Grisham, L. R.; Davidson, R. C.

2014-10-01

A 40 keV Ar+ beam with a dimensionless perveance of 4 ×10-4 is propagated through a Ferroelectric Plasma Source (FEPS) to determine the effects of charge neutralization on the transverse beam profile. Neutralization is established 5 μs after the FEPS is triggered, and lasts between 10 and 35 μs. When the beam is fully neutralized, the profile has a Gaussian shape with a half-angle divergence of 0.87°, which is attributed to ion optics. The effects of the resistance and capacitance in the pulser circuit on the FEPS discharge are studied. The electron current emitted by the FEPS is calculated from measurements of the forward and return currents in the circuit. Electron emission typically begins 0.5 μs after the driving pulse, lasting for tens of μs, which is similar to the duration of ion beam neutralization. The total emitted charge does not depend significantly on the resistance, but depends strongly on the storage capacitance. Lowering the capacitance from 141 nF to 47 nF results in a near-complete shut-off of charge emission, although the amplitude of the applied voltage pulse is as high as when high-density plasma is produced. Overall, the data suggest that ferroelectric effects are significant in the physics of the FEPS discharge.

Reverse Current in Solar Flares

NASA Technical Reports Server (NTRS)

Knight, J. W.; Sturrock, P. A.

1976-01-01

The theory that impulsive X ray bursts are produced by high energy electrons streaming from the corona to the chromosphere is investigated. Currents associated with these streams are so high that either the streams do not exist or their current is neutralized by a reverse current. Analysis of a simple model indicates that the primary electron stream leads to the development of an electric field in the ambient corona which decelerates the primary beam and produces a neutralizing reverse current. It appears that, in some circumstances, this electric field could prevent the primary beam from reaching the chromosphere. In any case, the electric field acts as an energy exchange mechanism, extracting kinetic energy from the primary beam and using it to heat the ambient plasma. This heating is typically so rapid that it must be expected to have important dynamical consequences.

The use of BMED for glyphosate recovery from glyphosate neutralization liquor in view of zero discharge.

PubMed

Shen, Jiangnan; Huang, Jie; Liu, Lifen; Ye, Wenyuan; Lin, Jiuyang; Van der Bruggen, Bart

2013-09-15

Alkaline glyphosate neutralization liquors containing a high salinity pose a severe environmental pollution problem by the pesticide industry. However, there is a high potential for glyphosate recovery due to the high concentration of glyphosate in the neutralization liquors. In the study, a three-compartment bipolar membrane electrodialysis (BMED) process was applied on pilot scale for the recovery of glyphosate and the production of base/acid with high concentration in view of zero discharge of wastewater. The experimental results demonstrate that BMED can remove 99.0% of NaCl from the feed solution and transform this fraction into HCl and NaOH with high concentration and purity. This is recycled for the hydrolysis reaction of the intermediate product generated by the means of the Mannich reaction of paraformaldehyde, glycine and dimethylphosphite catalyzed by triethylamine in the presence of HCl and reclamation of the triethylamine catalyst during the production process of glyphosate. The recovery of glyphosate in the feed solution was over 96%, which is acceptable for industrial production. The current efficiency for producing NaOH with a concentration of 2.0 mol L(-1) is above 67% and the corresponding energy consumption is 2.97 kWh kg(-1) at a current density of 60 mA cm(-2). The current efficiency increases and energy consumption decreases as the current density decreases, to 87.13% and 2.37 kWh kg(-1), respectively, at a current density of 30 mA cm(-2). Thus, BMED has a high potential for desalination of glyphosate neutralization liquor and glyphosate recovery, aiming at zero discharge and resource recycling in industrial application. Copyright © 2013 Elsevier B.V. All rights reserved.

Observation of events with an energetic forward neutron in deep inelastic scattering at HERA

NASA Astrophysics Data System (ADS)

Derrick, M.; Krakauer, D.; Magill, S.; Mikunas, D.; Musgrave, B.; Okrasinski, J. R.; Repond, J.; Stanek, R.; Talaga, R. L.; Zhang, H.; Mattingly, M. C. K.; Bari, G.; Basile, M.; Bellagamba, L.; Boscherini, D.; Bruni, A.; Bruni, G.; Bruni, P.; Cara Romeo, G.; Castellini, G.; Cifarelli, L.; Cindolo, F.; Contin, A.; Corradi, M.; Gialas, I.; Giusti, P.; Iacobucci, G.; Laurenti, G.; Levi, G.; Margotti, A.; Massam, T.; Nania, R.; Palmonari, F.; Polini, A.; Sartorelli, G.; Zamora Garcia, Y.; Zichichi, A.; Amelung, C.; Bornheim, A.; Crittenden, J.; Deffner, R.; Doeker, T.; Eckert, M.; Feld, L.; Frey, A.; Geerts, M.; Grothe, M.; Hartmann, H.; Heinloth, K.; Heinz, L.; Hilger, E.; Jakob, H.-P.; Katz, U. F.; Mengel, S.; Paul, E.; Pfeiffer, M.; Rembser, Ch.; Schramm, D.; Stamm, J.; Wedemeyer, R.; Campbell-Robson, S.; Cassidy, A.; Cottingham, W. N.; Dyce, N.; Foster, B.; George, S.; Hayes, M. E.; Heath, G. P.; Heath, H. F.; Piccioni, D.; Roff, D. G.; Tapper, R. J.; Yoshida, R.; Arneodo, M.; Ayad, R.; Capua, M.; Garfagnini, A.; Iannotti, L.; Schioppa, M.; Susinno, G.; Caldwell, A.; Cartiglia, N.; Jing, Z.; Liu, W.; Parsons, J. A.; Titz, S.; Sciulli, F.; Straub, P. B.; Wai, L.; Yang, S.; Zhu, Q.; Borzemski, P.; Chwastowski, J.; Eskreys, A.; Jakubowski, Z.; Przybycień, M. B.; Zachara, M.; Zawiejski, L.; Adamczyk, L.; Bednarek, B.; Jeleń, K.; Kisielewska, D.; Kowalski, T.; Przybycień, M.; Rulikowska-Zarȩbska, E.; Suszycki, L.; Zajaç, J.; Duliński, Z.; Kotański, A.; Abbiendi, G.; Bauerdick, L. A. T.; Behrens, U.; Beier, H.; Bienlein, J. K.; Cases, G.; Deppe, O.; Desler, K.; Drews, G.; Flasiński, M.; Gilkinson, D. J.; Glasman, C.; Göttlicher, P.; Große-Knetter, J.; Haas, T.; Hain, W.; Hasell, D.; Heßling, H.; Iga, Y.; Johnson, K. F.; Joos, P.; Kasemann, M.; Klanner, R.; Koch, W.; Kötz, U.; Kowalski, H.; Labs, J.; Ladage, A.; Löhr, B.; Löwe, M.; Lüke, D.; Mainusch, J.; Mańczak, O.; Milewski, J.; Monteiro, T.; Ng, J. S. T.; Notz, D.; Ohrenberg, K.; Poitrzkowski, K.; Roco, M.; Rohde, M.; Roldán, J.; Schneekloth, U.; Schulz, W.; Selonke, F.; Surrow, B.; Voß, T.; Westphal, D.; Wolf, G.; Wollmer, U.; Youngman, C.; Zeuner, W.; Grabosch, H. J.; Kharchilava, A.; Mari, S. M.; Meyer, A.; Schlenstedt, S.; Wulff, N.; Barbagli, G.; Gallo, E.; Pelfer, P.; Maccarrone, G.; De Pasquale, S.; Votano, L.; Bamberger, A.; Eisenhardt, S.; Trefzger, T.; Wölfle, S.; Bromley, J. T.; Brook, N. H.; Bussey, P. J.; Doyle, A. T.; Saxon, D. H.; Sinclair, L. E.; Utley, M. L.; Wilson, A. S.; Dannemann, A.; Holm, U.; Horstmann, D.; Sinkus, R.; Wick, K.; Burow, B. D.; Hagge, L.; Lohrmann, E.; Poelz, G.; Schott, W.; Zetsche, F.; Bacon, T. C.; Brümmer, N.; Butterworth, I.; Harris, V. L.; Howell, G.; Hung, B. H. Y.; Lamberti, L.; Long, K. R.; Miller, D. B.; Pavel, N.; Prinias, A.; Sedgbeer, J. K.; Sideris, D.; Whitfield, A. F.; Mallik, U.; Wang, M. Z.; Wang, S. M.; Wu, J. T.; Cloth, P.; Filges, D.; An, S. H.; Cho, G. H.; Ko, B. J.; Lee, S. B.; Nam, S. W.; Park, H. S.; Park, S. K.; Kartik, S.; Kim, H.-J.; McNeil, R. R.; Metcalf, W.; Nadendla, V. K.; Barreiro, F.; Fernandez, J. P.; Graciani, R.; Hernández, J. M.; Hervás, L.; Labarga, L.; Martinez, M.; del Peso, J.; Puga, J.; Terron, J.; de Trocóniz, J. F.; Corriveau, F.; Hanna, D. S.; Hartmann, J.; Hung, L. W.; Lim, J. N.; Matthews, C. G.; Patel, P. M.; Riveline, M.; Stairs, D. G.; St-Laurent, M.; Ullmann, R.; Zacek, G.; Tsurugai, T.; Bashkirov, V.; Dolgoshein, B. A.; Stifutkin, A.; Bashindzhagyan, G. L.; Ermolov, P. F.; Gladilin, L. K.; Golubkov, Yu. A.; Kobrin, V. D.; Korzhavina, I. A.; Kuzmin, V. A.; Lukina, O. Yu.; Proskuryakov, A. S.; Savin, A. A.; Shcheglova, L. M.; Solomin, A. N.; Zotov, N. P.; Botje, M.; Chlebana, F.; Engelen, J.; de Kamps, M.; Kooijman, P.; Kruse, A.; van Sighem, A.; Tiecke, H.; Verkerke, W.; Vossebeld, J.; Vreeswijk, M.; Wiggers, L.; de Wolf, E.; van Woudenberg, R.; Acosta, D.; Bylsma, B.; Durkin, L. S.; Gilmore, J.; Li, C.; Ling, T. Y.; Nylander, P.; Park, I. H.; Romanowski, T. A.; Bailey, D. S.; Cashmore, R. J.; Cooper-Sarkar, A. M.; Devenish, R. C. E.; Harnew, N.; Lancaster, M.; Lindemann, L.; McFall, J. D.; Nath, C.; Noyes, V. A.; Quadt, A.; Tickner, J. R.; Uijterwaal, H.; Walczak, R.; Waters, D. S.; Wilson, F. F.; Yip, T.; Bertolin, A.; Brugnera, R.; Carlin, R.; Dal Corso, F.; De Giorgi, M.; Dosselli, U.; Limentani, S.; Morandin, M.; Posocco, M.; Stanco, L.; Stroili, R.; Voci, C.; Zuin, F.; Bulmahn, J.; Feild, R. G.; Oh, B. Y.; Whitmore, J. J.; D'Agostini, G.; Marini, G.; Nigro, A.; Tassi, E.; Hart, J. C.; McCubbin, N. A.; Shah, T. P.; Barberis, E.; Dubbs, T.; Heusch, C.; Van Hook, M.; Lockman, W.; Rahn, J. T.; Sadrozinski, H. F.-W.; Seiden, A.; Williams, D. C.; Biltzinger, J.; Seifert, R. J.; Schwarzer, O.; Walenta, A. H.; Zech, G.; Abramowicz, H.; Briskin, G.; Dagan, S.; Levy, A.; Fleck, J. I.; Inuzuka, M.; Ishii, T.; Kuze, M.; Mine, S.; Nakao, M.; Suzuki, I.; Tokushuku, K.; Umemori, K.; Yamada, S.; Yamazaki, Y.; Chiba, M.; Hamatsu, R.; Hirose, T.; Homma, K.; Kitamura, S.; Matsushita, T.; Yamauchi, K.; Cirio, R.; Costa, M.; Ferrero, M. I.; Maselli, S.; Peroni, C.; Sacchi, R.; Solano, A.; Staiano, A.; Dardo, M.; Bailey, D. C.; Benard, F.; Brkic, M.; Fagerstroem, C.-P.; Hartner, G. F.; Joo, K. K.; Levman, G. M.; Martin, J. F.; Orr, R. S.; Polenz, S.; Sampson, C. R.; Simmons, D.; Teuscher, R. J.; Butterworth, J. M.; Catterall, C. D.; Jones, T. W.; Kaziewicz, P. B.; Lane, J. B.; Saunders, R. L.; Shulman, J.; Sutton, M. R.; Lu, B.; Mo, L. W.; Bogusz, W.; Ciborowski, J.; Gajewski, J.; Grzelak, G.; Kasprzak, M.; Krzyżanowski, M.; Muchorowski, K.; Nowak, R. J.; Pawlak, J. M.; Tymieniecka, T.; Wróblewski, A. K.; Zakrzewski, J. A.; Żarnecki, A. F.; Adamus, M.; Coldewey, C.; Eisenberg, Y.; Hochman, D.; Karshon, U.; Revel, D.; Zer-Zion, D.; Badgett, W. F.; Breitweg, J.; Chapin, D.; Cross, R.; Dasu, S.; Foudas, C.; Loveless, R. J.; Mattingly, S.; Reeder, D. D.; Silverstein, S.; Smith, W. H.; Vaiciulis, A.; Wodarczyk, M.; Bhadra, S.; Cardy, M. L.; Fagerstroem, C.-P.; Frisken, W. R.; Furutani, K. M.; Khakzad, M.; Murray, W. N.; Schmidke, W. B.; ZEUS Collaboration

1996-02-01

In deep inelastic neutral current scattering of positrons and protons at the center of mass energy of 300 GeV, we observe, with the ZEUS detector, events with a high energy neutron produced at very small scattering angles with respect to the proton direction. The events constitute a fixed fraction of the deep inelastic, neutral current event sample independent of Bjorken x and Q2 in the range 3 · 10 -4 < xBJ < 6 · 10 -3 and 10 < Q2 < 100 GeV 2.

A search for matter enhanced neutrino oscillations through measurements of day and night solar neutrino fluxes at the Sudbury Neutrino Observatory

NASA Astrophysics Data System (ADS)

Miknaitis, Kathryn Kelly Schaffer

The Sudbury Neutrino Observatory (SNO) is a heavy-water Cherenkov detector designed to study 8B neutrinos from the sun. Through the charged-current (CC) and neutral-current (NC) reactions of neutrinos on deuterium, SNO separately determines the flux of electron neutrinos and the flux of all active flavors of solar 8B neutrinos. SNO is also sensitive to the elastic scattering (ES) of neutrinos on electrons in the heavy water. Measurements of the CC and NC rates in SNO have conclusively demonstrated solar neutrino flavor change. This flavor change is believed to be caused by matter-enhanced oscillations in the sun, through the Mikheyev-Smirnov-Wolfenstein (MSW) effect. Matter effects could also change the flavor composition of neutrinos that traverse the earth. A comparison of the day and night measured CC flux at SNO directly tests for the MSW effect and contributes to constraints on neutrino oscillation parameters in the MSW model. We perform measurements of the day and night neutrino fluxes using data from the second phase of SNO, in which salt (NaCl) was added to the heavy water to enhance sensitivity to the NC reaction. Better discrimination between CC and NC events in the salt phase allows the fluxes to be determined without constraining the neutrino energy spectrum. The day-night asymmetry in the CC flux measured in this model-independent analysis is ACC = [-5.6 +/- 7.4(stat.) +/- 5.3(syst.)]%, where the asymmetry is defined as the difference between the night and day values divided by their average. The asymmetries in the NC and ES fluxes are ANC = [4.2 +/- 8.6(stat.) +/- 7.2(syst.)]%, and AES = (14.6 +/- 19.8(stat.) +/- 3.3(syst.)]%. The neutral current asymmetry is expected to be zero assuming standard neutrino oscillations. When we constrain it to be zero, we obtain ACC = [-3.7 +/- 6.3(stat.) +/- 3.2(syst.)]% and AES = [15.3 +/- 19.8(stat.) +/- 3.0(syst.)]%. The day and night energy spectra from the CC reaction have been measured and show no evidence for day-night variations as a function of energy.

Change of pH during excess sludge fermentation under alkaline, acidic and neutral conditions.

PubMed

Yuan, Yue; Peng, Yongzhen; Liu, Ye; Jin, Baodan; Wang, Bo; Wang, Shuying

2014-12-01

The change in pH during excess sludge (ES) fermentation of varying sludge concentrations was investigated in a series of reactors at alkaline, acidic, and neutral pHs. The results showed that the changes were significantly affected by fermentative conditions. Under different conditions, pH exhibited changing profiles. When ES was fermented under alkaline conditions, pH decreased in a range of (10±1). At the beginning of alkaline fermentation, pH dropped significantly, at intervals of 4h, 4h, and 5h with sludge concentrations of 8665.6mg/L, 6498.8mg/L, and 4332.5mg/L, then it would become moderate. However, under acidic conditions, pH increased from 4 to 5. Finally, under neutral conditions pH exhibited a decrease then an increase throughout entire fermentation process. Further study showed short-chain fatty acids (SCFAs), ammonia nitrogen and cations contributed to pH change under various fermentation conditions. This study presents a novel strategy based on pH change to predict whether SCFAs reach their stable stage. Copyright © 2014 Elsevier Ltd. All rights reserved.

Inferred flows of electric currents in solar active regions

NASA Technical Reports Server (NTRS)

Ding, Y. J.; Hong, Q. F.; Hagyard, M. J.; Deloach, A. C.

1985-01-01

Techniques to identify sources of major current systems in active regions and their channels of flow are explored. Measured photospheric vector magnetic fields together with high resolution white light and H-alpha photographs provide the data base to derive the current systems in the photosphere and chromosphere of a solar active region. Simple mathematical constructions of active region fields and currents are used to interpret these data under the assumptions that the fields in the lower atmosphere (below 200 km) may not be force free but those in the chromosphere and higher are. The results obtained for the complex active region AR 2372 are: (1) Spots exhibiting significant spiral structure in the penumbral filaments were the source of vertical currents at the photospheric surface; (2) Magnetic neutral lines where the transverse magnetic field was strongly sheared were channels along which a strong current system flowed; (3) The inferred current systems produced a neutral sheet and oppositely-flowing currents in the area of the magnetic delta configuration that was the site of flaring.

Long-pulse power-supply system for EAST neutral-beam injectors

NASA Astrophysics Data System (ADS)

Liu, Zhimin; Jiang, Caichao; Pan, Junjun; Liu, Sheng; Xu, Yongjian; Chen, Shiyong; Hu, Chundong; NBI Team

2017-05-01

The long-pulse power-supply system equipped for the 4 MW beam-power ion source is comprised of three units at ASIPP (Institute of Plasma Physics, Chinese Academy of Sciences): one for the neutral-beam test stand and two for the EAST neutral-beam injectors (NBI-1 and NBI-2, respectively). Each power supply system consists of two low voltage and high current DC power supplies for plasma generation of the ion source, and two high voltage and high current DC power supplies for the accelerator grid system. The operation range of the NB power supply is about 80 percent of the design value, which is the safe and stable operation range. At the neutral-beam test stand, a hydrogen ion beam with a beam pulse of 150 s, beam power of 1.5 MW and beam energy of 50 keV was achieved during the long-pulse testing experiments. The result shows that the power-supply system meets the requirements of the EAST-NBIs fully and lays a basis for achieving plasma heating.

New approach to flavor symmetry and an extended naturalness principle

NASA Astrophysics Data System (ADS)

Barr, S. M.

2010-09-01

A class of nonsupersymmetric extensions of the standard model is proposed in which there is a multiplicity of light scalar doublets in a multiplet of a nonabelian family group with the standard model Higgs doublet. Anthropic tuning makes the latter light, and consequently the other scalar doublets remain light because of the family symmetry. The family symmetry greatly constrains the pattern of flavor-changing neutral-current interactions (FCNC) and p decay operators coming from scalar-exchange. Such models show that useful constraints on model-building can come from an extended naturalness principle when the electroweak scale is anthropically tuned.

Search for rare and forbidden decays D+ --> h+/- e+/- e+.

PubMed

He, Q; Muramatsu, H; Park, C S; Thorndike, E H; Coan, T E; Gao, Y S; Liu, F; Artuso, M; Boulahouache, C; Blusk, S; Butt, J; Dorjkhaidav, O; Li, J; Menaa, N; Mountain, R; Nandakumar, R; Randrianarivony, K; Redjimi, R; Sia, R; Skwarnicki, T; Stone, S; Wang, J C; Zhang, K; Csorna, S E; Bonvicini, G; Cinabro, D; Dubrovin, M; Briere, R A; Chen, G P; Chen, J; Ferguson, T; Tatishvili, G; Vogel, H; Watkins, M E; Rosner, J L; Adam, N E; Alexander, J P; Berkelman, K; Cassel, D G; Crede, V; Duboscq, J E; Ecklund, K M; Ehrlich, R; Fields, L; Galik, R S; Gibbons, L; Gittelman, B; Gray, R; Gray, S W; Hartill, D L; Heltsley, B K; Hertz, D; Jones, C D; Kandaswamy, J; Kreinick, D L; Kuznetsov, V E; Mahlke-Krüger, H; Meyer, T O; Onyisi, P U E; Patterson, J R; Peterson, D; Phillips, E A; Pivarski, J; Riley, D; Ryd, A; Sadoff, A J; Schwarthoff, H; Shi, X; Shepherd, M R; Stroiney, S; Sun, W M; Urner, D; Wilksen, T; Weaver, K M; Weinberger, M; Athar, S B; Avery, P; Breva-Newell, L; Patel, R; Potlia, V; Stoeck, H; Yelton, J; Rubin, P; Cawlfield, C; Eisenstein, B I; Gollin, G D; Karliner, I; Kim, D; Lowrey, N; Naik, P; Sedlack, C; Selen, M; White, E J; Williams, J; Wiss, J; Asner, D M; Edwards, K W; Besson, D; Pedlar, T K; Cronin-Hennessy, D; Gao, K Y; Gong, D T; Hietala, J; Kubota, Y; Klein, T; Lang, B W; Li, S Z; Poling, R; Scott, A W; Smith, A; Dobbs, S; Metreveli, Z; Seth, K K; Tomaradze, A; Zweber, P; Ernst, J; Severini, H; Dytman, S A; Love, W; Mehrabyan, S; Mueller, J A; Savinov, V; Li, Z; Lopez, A; Mendez, H; Ramirez, J; Huang, G S; Miller, D H; Pavlunin, V; Sanghi, B; Shipsey, I P J; Adams, G S; Cravey, M; Cummings, J P; Danko, I; Napolitano, J

2005-11-25

Using 0.8 x 10(6) D+ D- pairs collected with the CLEO-c detector at the psi(3770) resonance, we have searched for flavor-changing neutral current and lepton-number-violating decays of D+ mesons to final states with dielectrons. We find no indication of either, obtaining 90% confidence level upper limits of B(D+ --> pi+ e+ e-) < 7.4 x 10(-6), B(D+ --> pi- e+ d+) < 3.6 x 10(-6), B(D+ --> K+ e+ e-) < 6.2 x 10(-6), and B(D+ --> K- e+ e+) < 4.5 x 10(-6).

Search for the rare decay Λc+→p μ+μ-

NASA Astrophysics Data System (ADS)

Aaij, R.; Adeva, B.; Adinolfi, M.; Ajaltouni, Z.; Akar, S.; Albrecht, J.; Alessio, F.; Alexander, M.; Alfonso Albero, A.; Ali, S.; Alkhazov, G.; Alvarez Cartelle, P.; Alves, A. A.; Amato, S.; Amerio, S.; Amhis, Y.; An, L.; Anderlini, L.; Andreassi, G.; Andreotti, M.; Andrews, J. E.; Appleby, R. B.; Archilli, F.; d'Argent, P.; Arnau Romeu, J.; Artamonov, A.; Artuso, M.; Aslanides, E.; Atzeni, M.; Auriemma, G.; Baalouch, M.; Babuschkin, I.; Bachmann, S.; Back, J. J.; Badalov, A.; Baesso, C.; Baker, S.; Balagura, V.; Baldini, W.; Baranov, A.; Barlow, R. J.; Barschel, C.; Barsuk, S.; Barter, W.; Baryshnikov, F.; Batozskaya, V.; Battista, V.; Bay, A.; Beaucourt, L.; Beddow, J.; Bedeschi, F.; Bediaga, I.; Beiter, A.; Bel, L. J.; Beliy, N.; Bellee, V.; Belloli, N.; Belous, K.; Belyaev, I.; Ben-Haim, E.; Bencivenni, G.; Benson, S.; Beranek, S.; Berezhnoy, A.; Bernet, R.; Berninghoff, D.; Bertholet, E.; Bertolin, A.; Betancourt, C.; Betti, F.; Bettler, M. O.; van Beuzekom, M.; Bezshyiko, Ia.; Bifani, S.; Billoir, P.; Birnkraut, A.; Bizzeti, A.; Bjørn, M.; Blake, T.; Blanc, F.; Blusk, S.; Bocci, V.; Boettcher, T.; Bondar, A.; Bondar, N.; Bordyuzhin, I.; Borghi, S.; Borisyak, M.; Borsato, M.; Bossu, F.; Boubdir, M.; Bowcock, T. J. V.; Bowen, E.; Bozzi, C.; Braun, S.; Brodzicka, J.; Brundu, D.; Buchanan, E.; Burr, C.; Bursche, A.; Buytaert, J.; Byczynski, W.; Cadeddu, S.; Cai, H.; Calabrese, R.; Calladine, R.; Calvi, M.; Calvo Gomez, M.; Camboni, A.; Campana, P.; Campora Perez, D. H.; Capriotti, L.; Carbone, A.; Carboni, G.; Cardinale, R.; Cardini, A.; Carniti, P.; Carson, L.; Carvalho Akiba, K.; Casse, G.; Cassina, L.; Cattaneo, M.; Cavallero, G.; Cenci, R.; Chamont, D.; Chapman, M. G.; Charles, M.; Charpentier, Ph.; Chatzikonstantinidis, G.; Chefdeville, M.; Chen, S.; Cheung, S. F.; Chitic, S.-G.; Chobanova, V.; Chrzaszcz, M.; Chubykin, A.; Ciambrone, P.; Cid Vidal, X.; Ciezarek, G.; Clarke, P. E. L.; Clemencic, M.; Cliff, H. V.; Closier, J.; Coco, V.; Cogan, J.; Cogneras, E.; Cogoni, V.; Cojocariu, L.; Collins, P.; Colombo, T.; Comerma-Montells, A.; Contu, A.; Coombs, G.; Coquereau, S.; Corti, G.; Corvo, M.; Costa Sobral, C. M.; Couturier, B.; Cowan, G. A.; Craik, D. C.; Crocombe, A.; Cruz Torres, M.; Currie, R.; D'Ambrosio, C.; Da Cunha Marinho, F.; Da Silva, C. L.; Dall'Occo, E.; Dalseno, J.; Davis, A.; De Aguiar Francisco, O.; De Bruyn, K.; De Capua, S.; De Cian, M.; De Miranda, J. M.; De Paula, L.; De Serio, M.; De Simone, P.; Dean, C. T.; Decamp, D.; Del Buono, L.; Dembinski, H.-P.; Demmer, M.; Dendek, A.; Derkach, D.; Deschamps, O.; Dettori, F.; Dey, B.; Di Canto, A.; Di Nezza, P.; Dijkstra, H.; Dordei, F.; Dorigo, M.; Dosil Suárez, A.; Douglas, L.; Dovbnya, A.; Dreimanis, K.; Dufour, L.; Dujany, G.; Durante, P.; Durham, J. M.; Dutta, D.; Dzhelyadin, R.; Dziewiecki, M.; Dziurda, A.; Dzyuba, A.; Easo, S.; Egede, U.; Egorychev, V.; Eidelman, S.; Eisenhardt, S.; Eitschberger, U.; Ekelhof, R.; Eklund, L.; Ely, S.; Esen, S.; Evans, H. M.; Evans, T.; Falabella, A.; Farley, N.; Farry, S.; Fazzini, D.; Federici, L.; Ferguson, D.; Fernandez, G.; Fernandez Declara, P.; Fernandez Prieto, A.; Ferrari, F.; Ferreira Lopes, L.; Ferreira Rodrigues, F.; Ferro-Luzzi, M.; Filippov, S.; Fini, R. A.; Fiorini, M.; Firlej, M.; Fitzpatrick, C.; Fiutowski, T.; Fleuret, F.; Fontana, M.; Fontanelli, F.; Forty, R.; Franco Lima, V.; Frank, M.; Frei, C.; Fu, J.; Funk, W.; Furfaro, E.; Färber, C.; Gabriel, E.; Gallas Torreira, A.; Galli, D.; Gallorini, S.; Gambetta, S.; Gandelman, M.; Gandini, P.; Gao, Y.; Garcia Martin, L. M.; García Pardiñas, J.; Garra Tico, J.; Garrido, L.; Gascon, D.; Gaspar, C.; Gavardi, L.; Gazzoni, G.; Gerick, D.; Gersabeck, E.; Gersabeck, M.; Gershon, T.; Ghez, Ph.; Gianı, S.; Gibson, V.; Girard, O. G.; Giubega, L.; Gizdov, K.; Gligorov, V. V.; Golubkov, D.; Golutvin, A.; Gomes, A.; Gorelov, I. V.; Gotti, C.; Govorkova, E.; Grabowski, J. P.; Graciani Diaz, R.; Granado Cardoso, L. A.; Graugés, E.; Graverini, E.; Graziani, G.; Grecu, A.; Greim, R.; Griffith, P.; Grillo, L.; Gruber, L.; Gruberg Cazon, B. R.; Grünberg, O.; Gushchin, E.; Guz, Yu.; Gys, T.; Göbel, C.; Hadavizadeh, T.; Hadjivasiliou, C.; Haefeli, G.; Haen, C.; Haines, S. C.; Hamilton, B.; Han, X.; Hancock, T. H.; Hansmann-Menzemer, S.; Harnew, N.; Harnew, S. T.; Hasse, C.; Hatch, M.; He, J.; Hecker, M.; Heinicke, K.; Heister, A.; Hennessy, K.; Henrard, P.; Henry, L.; van Herwijnen, E.; Heß, M.; Hicheur, A.; Hill, D.; Hopchev, P. H.; Hu, W.; Huang, W.; Huard, Z. C.; Hulsbergen, W.; Humair, T.; Hushchyn, M.; Hutchcroft, D.; Ibis, P.; Idzik, M.; Ilten, P.; Jacobsson, R.; Jalocha, J.; Jans, E.; Jawahery, A.; Jezabek, M.; Jiang, F.; John, M.; Johnson, D.; Jones, C. R.; Joram, C.; Jost, B.; Jurik, N.; Kandybei, S.; Karacson, M.; Kariuki, J. M.; Karodia, S.; Kazeev, N.; Kecke, M.; Keizer, F.; Kelsey, M.; Kenzie, M.; Ketel, T.; Khairullin, E.; Khanji, B.; Khurewathanakul, C.; Kim, K. E.; Kirn, T.; Klaver, S.; Klimaszewski, K.; Klimkovich, T.; Koliiev, S.; Kolpin, M.; Kopecna, R.; Koppenburg, P.; Kosmyntseva, A.; Kotriakhova, S.; Kozeiha, M.; Kravchuk, L.; Kreps, M.; Kress, F.; Krokovny, P.; Krzemien, W.; Kucewicz, W.; Kucharczyk, M.; Kudryavtsev, V.; Kuonen, A. K.; Kvaratskheliya, T.; Lacarrere, D.; Lafferty, G.; Lai, A.; Lanfranchi, G.; Langenbruch, C.; Latham, T.; Lazzeroni, C.; Le Gac, R.; Leflat, A.; Lefrançois, J.; Lefèvre, R.; Lemaitre, F.; Lemos Cid, E.; Leroy, O.; Lesiak, T.; Leverington, B.; Li, P.-R.; Li, T.; Li, Y.; Li, Z.; Liang, X.; Likhomanenko, T.; Lindner, R.; Lionetto, F.; Lisovskyi, V.; Liu, X.; Loh, D.; Loi, A.; Longstaff, I.; Lopes, J. H.; Lucchesi, D.; Lucio Martinez, M.; Luo, H.; Lupato, A.; Luppi, E.; Lupton, O.; Lusiani, A.; Lyu, X.; Machefert, F.; Maciuc, F.; Macko, V.; Mackowiak, P.; Maddrell-Mander, S.; Maev, O.; Maguire, K.; Maisuzenko, D.; Majewski, M. W.; Malde, S.; Malecki, B.; Malinin, A.; Maltsev, T.; Manca, G.; Mancinelli, G.; Marangotto, D.; Maratas, J.; Marchand, J. F.; Marconi, U.; Marin Benito, C.; Marinangeli, M.; Marino, P.; Marks, J.; Martellotti, G.; Martin, M.; Martinelli, M.; Martinez Santos, D.; Martinez Vidal, F.; Massafferri, A.; Matev, R.; Mathad, A.; Mathe, Z.; Matteuzzi, C.; Mauri, A.; Maurice, E.; Maurin, B.; Mazurov, A.; McCann, M.; McNab, A.; McNulty, R.; Mead, J. V.; Meadows, B.; Meaux, C.; Meier, F.; Meinert, N.; Melnychuk, D.; Merk, M.; Merli, A.; Michielin, E.; Milanes, D. A.; Millard, E.; Minard, M.-N.; Minzoni, L.; Mitzel, D. S.; Mogini, A.; Molina Rodriguez, J.; Mombächer, T.; Monroy, I. A.; Monteil, S.; Morandin, M.; Morello, M. J.; Morgunova, O.; Moron, J.; Morris, A. B.; Mountain, R.; Muheim, F.; Mulder, M.; Müller, D.; Müller, J.; Müller, K.; Müller, V.; Naik, P.; Nakada, T.; Nandakumar, R.; Nandi, A.; Nasteva, I.; Needham, M.; Neri, N.; Neubert, S.; Neufeld, N.; Neuner, M.; Nguyen, T. D.; Nguyen-Mau, C.; Nieswand, S.; Niet, R.; Nikitin, N.; Nikodem, T.; Nogay, A.; O'Hanlon, D. P.; Oblakowska-Mucha, A.; Obraztsov, V.; Ogilvy, S.; Oldeman, R.; Onderwater, C. J. G.; Ossowska, A.; Otalora Goicochea, J. M.; Owen, P.; Oyanguren, A.; Pais, P. R.; Palano, A.; Palutan, M.; Panshin, G.; Papanestis, A.; Pappagallo, M.; Pappalardo, L. L.; Parker, W.; Parkes, C.; Passaleva, G.; Pastore, A.; Patel, M.; Patrignani, C.; Pearce, A.; Pellegrino, A.; Penso, G.; Pepe Altarelli, M.; Perazzini, S.; Pereima, D.; Perret, P.; Pescatore, L.; Petridis, K.; Petrolini, A.; Petrov, A.; Petruzzo, M.; Picatoste Olloqui, E.; Pietrzyk, B.; Pietrzyk, G.; Pikies, M.; Pinci, D.; Pisani, F.; Pistone, A.; Piucci, A.; Placinta, V.; Playfer, S.; Plo Casasus, M.; Polci, F.; Poli Lener, M.; Poluektov, A.; Polyakov, I.; Polycarpo, E.; Pomery, G. J.; Ponce, S.; Popov, A.; Popov, D.; Poslavskii, S.; Potterat, C.; Price, E.; Prisciandaro, J.; Prouve, C.; Pugatch, V.; Puig Navarro, A.; Pullen, H.; Punzi, G.; Qian, W.; Qin, J.; Quagliani, R.; Quintana, B.; Rachwal, B.; Rademacker, J. H.; Rama, M.; Ramos Pernas, M.; Rangel, M. S.; Raniuk, I.; Ratnikov, F.; Raven, G.; Ravonel Salzgeber, M.; Reboud, M.; Redi, F.; Reichert, S.; dos Reis, A. C.; Remon Alepuz, C.; Renaudin, V.; Ricciardi, S.; Richards, S.; Rihl, M.; Rinnert, K.; Robbe, P.; Robert, A.; Rodrigues, A. B.; Rodrigues, E.; Rodriguez Lopez, J. A.; Rogozhnikov, A.; Roiser, S.; Rollings, A.; Romanovskiy, V.; Romero Vidal, A.; Rotondo, M.; Rudolph, M. S.; Ruf, T.; Ruiz Valls, P.; Ruiz Vidal, J.; Saborido Silva, J. J.; Sadykhov, E.; Sagidova, N.; Saitta, B.; Salustino Guimaraes, V.; Sanchez Mayordomo, C.; Sanmartin Sedes, B.; Santacesaria, R.; Santamarina Rios, C.; Santimaria, M.; Santovetti, E.; Sarpis, G.; Sarti, A.; Satriano, C.; Satta, A.; Saunders, D. M.; Savrina, D.; Schael, S.; Schellenberg, M.; Schiller, M.; Schindler, H.; Schmelling, M.; Schmelzer, T.; Schmidt, B.; Schneider, O.; Schopper, A.; Schreiner, H. F.; Schubiger, M.; Schune, M. H.; Schwemmer, R.; Sciascia, B.; Sciubba, A.; Semennikov, A.; Sepulveda, E. S.; Sergi, A.; Serra, N.; Serrano, J.; Sestini, L.; Seyfert, P.; Shapkin, M.; Shcheglov, Y.; Shears, T.; Shekhtman, L.; Shevchenko, V.; Siddi, B. G.; Silva Coutinho, R.; Silva de Oliveira, L.; Simi, G.; Simone, S.; Sirendi, M.; Skidmore, N.; Skwarnicki, T.; Smith, I. T.; Smith, J.; Smith, M.; Soares Lavra, l.; Sokoloff, M. D.; Soler, F. J. P.; Souza De Paula, B.; Spaan, B.; Spradlin, P.; Stagni, F.; Stahl, M.; Stahl, S.; Stefko, P.; Stefkova, S.; Steinkamp, O.; Stemmle, S.; Stenyakin, O.; Stepanova, M.; Stevens, H.; Stone, S.; Storaci, B.; Stracka, S.; Stramaglia, M. E.; Straticiuc, M.; Straumann, U.; Strokov, S.; Sun, J.; Sun, L.; Swientek, K.; Syropoulos, V.; Szumlak, T.; Szymanski, M.; T'Jampens, S.; Tayduganov, A.; Tekampe, T.; Tellarini, G.; Teubert, F.; Thomas, E.; van Tilburg, J.; Tilley, M. J.; Tisserand, V.; Tobin, M.; Tolk, S.; Tomassetti, L.; Tonelli, D.; Tourinho Jadallah Aoude, R.; Tournefier, E.; Traill, M.; Tran, M. T.; Tresch, M.; Trisovic, A.; Tsaregorodtsev, A.; Tsopelas, P.; Tully, A.; Tuning, N.; Ukleja, A.; Usachov, A.; Ustyuzhanin, A.; Uwer, U.; Vacca, C.; Vagner, A.; Vagnoni, V.; Valassi, A.; Valat, S.; Valenti, G.; Vazquez Gomez, R.; Vazquez Regueiro, P.; Vecchi, S.; van Veghel, M.; Velthuis, J. J.; Veltri, M.; Veneziano, G.; Venkateswaran, A.; Verlage, T. A.; Vernet, M.; Vesterinen, M.; Viana Barbosa, J. V.; Vieira, D.; Vieites Diaz, M.; Viemann, H.; Vilasis-Cardona, X.; Vitti, M.; Volkov, V.; Vollhardt, A.; Voneki, B.; Vorobyev, A.; Vorobyev, V.; Voß, C.; de Vries, J. A.; Vázquez Sierra, C.; Waldi, R.; Walsh, J.; Wang, J.; Wang, Y.; Ward, D. R.; Wark, H. M.; Watson, N. K.; Websdale, D.; Weiden, A.; Weisser, C.; Whitehead, M.; Wicht, J.; Wilkinson, G.; Wilkinson, M.; Williams, M.; Williams, M.; Williams, T.; Wilson, F. F.; Wimberley, J.; Winn, M.; Wishahi, J.; Wislicki, W.; Witek, M.; Wormser, G.; Wotton, S. A.; Wyllie, K.; Xie, Y.; Xu, M.; Xu, Q.; Xu, Z.; Xu, Z.; Yang, Z.; Yang, Z.; Yao, Y.; Yin, H.; Yu, J.; Yuan, X.; Yushchenko, O.; Zarebski, K. A.; Zavertyaev, M.; Zhang, L.; Zhang, Y.; Zhelezov, A.; Zheng, Y.; Zhu, X.; Zhukov, V.; Zonneveld, J. B.; Zucchelli, S.; LHCb Collaboration

2018-05-01

A search for the flavor-changing neutral-current decay Λc+→p μ+μ- is reported using a data set corresponding to an integrated luminosity of 3.0 fb-1 collected by the LHCb Collaboration. No significant signal is observed outside of the dimuon mass regions around the ϕ and ω resonances, and an upper limit is placed on the branching fraction of B ( Λc+→p μ+μ- ) <7.7 (9.6 )×10-8 at 90%(95%) confidence level. A significant signal is observed in the ω dimuon mass region for the first time.

Rare decays in quark flavour physics

NASA Astrophysics Data System (ADS)

Albrecht, Johannes; LHCb Collaboration

2016-04-01

Rare heavy-flavour decays are an ideal place to search for the effects of potential new particles that modify the decay rates or the Lorentz structure of the decay vertices. Recent results on Flavour Changing Neutral Current decays from the LHC are reviewed. An emphasis is put on the very rare decay Bs0 →μ+μ-, which was recently observed by the CMS and LHCb experiments, on a recent test of lepton universality in loop processes and on the analysis of the angular distributions of the B0 →K*0μ+μ- decays, both by the LHCb collaboration.

Lepton masses and mixings in orbifold models with three Higgs families

NASA Astrophysics Data System (ADS)

Escudero, N.; Muñoz, C.; Teixeira, A. M.

2007-12-01

We analyse the phenomenological viability of heterotic Z3 orbifolds with two Wilson lines, which naturally predict three supersymmetric families of matter and Higgs fields. Given that these models can accommodate realistic scenarios for the quark sector avoiding potentially dangerous flavour-changing neutral currents, we now address the leptonic sector, finding that viable orbifold configurations can in principle be obtained. In particular, it is possible to accomodate present data on charged lepton masses, while avoiding conflict with lepton flavour-violating decays. Concerning the generation of neutrino masses and mixings, we find that Z3 orbifolds offer several interesting possibilities.

Search for the rare decay B s 0 → μ + μ -

DOE PAGES

Abazov, V.M.; Abbott, B.; Abolins, M.; ...

2010-10-01

We present the results of a search for the flavor changing neutral current decay B 0 susing 6.1 fb -1 of pp⁻ collisions at collected by the D0 experiment at the Fermilab Tevatron Collider. The observed number of B 0 scandidates is consistent with background expectations. The resulting upper limit on the branching fraction is B (B 0 s → μ⁺μ⁻) < 5.1 x 10 -8 at the 95% C.L. This limit is a factor of 2.4 better than that of the previous D0 analysis and the best limit to date.

Structural basis for antibody-mediated neutralization of Lassa virus.

PubMed

Hastie, Kathryn M; Zandonatti, Michelle A; Kleinfelter, Lara M; Heinrich, Megan L; Rowland, Megan M; Chandran, Kartik; Branco, Luis M; Robinson, James E; Garry, Robert F; Saphire, Erica Ollmann

2017-06-02

The arenavirus Lassa causes severe hemorrhagic fever and a significant disease burden in West Africa every year. The glycoprotein, GPC, is the sole antigen expressed on the viral surface and the critical target for antibody-mediated neutralization. Here we present the crystal structure of the trimeric, prefusion ectodomain of Lassa GP bound to a neutralizing antibody from a human survivor at 3.2-angstrom resolution. The antibody extensively anchors two monomers together at the base of the trimer, and biochemical analysis suggests that it neutralizes by inhibiting conformational changes required for entry. This work illuminates pH-driven conformational changes in both receptor-binding and fusion subunits of Lassa virus, illustrates the unique assembly of the arenavirus glycoprotein spike, and provides a much-needed template for vaccine design against these threats to global health. Copyright © 2017, American Association for the Advancement of Science.

Role of Earth's plasmasphere in coupling of upper atmosphere

NASA Astrophysics Data System (ADS)

Singh, A. K.; Mishra, Sandhya; Dohare, S. K.

2010-02-01

The near-Earth space environment is a complex, ever changing system of magnetized plasmas whose behaviour has a profound impact upon our technology dependent society. The exploration of the cold, relatively dense, inner region of upper atmosphere (the plasmasphere) and its unexpectedly sharp outer boundary (the plasma pause) has proceeded through a combination of in-situ observations and ground based whistler observations. Studies have shown that plasmasphere is highly variable both spatially and temporally responding to changes in geomagnetic indices, ring current, penetration and shielding electric fields and subauroral electric fields. Consequently the plasmasphere exhibits erosion, emptying and refilling during active times. Infact, it is the electric field that plays one of the most important roles in coupling of upper atmosphere. The atmospheric dynamo is the main generator of the large-scale electric field in the upper atmosphere. It arises because of a special situation which electrons and ions move with different velocities across the magnetic field because of different collisions between electrons and neutral particles and ions with neutral particles. This process leads to charge separation and consequently to an electric field. In the present paper, storm/ quiet period VLF whistler data recorded at lower latitudes/mid latitudes are analyzed and attempt has been made to look at plasmasphere response on coupling of ionosphere and magnetosphere.

Frontolimbic dysfunction in response to facial emotion in borderline personality disorder: an event-related fMRI study

PubMed Central

Minzenberg, Michael J.; Fan, Jin; New, Antonia S.; Tang, Cheuk Y.; Siever, Larry J.

2007-01-01

Clinical hallmarks of borderline personality disorder (BPD) include social and emotional dysregulation. We tested a model of frontolimbic dysfunction in facial emotion processing in BPD. Groups of 12 unmedicated adults with BPD by DSM-IV and 12 demographically-matched healthy controls (HC) viewed facial expressions (Conditions) of neutral emotion, fear and anger, and made gender discriminations during rapid event-related functional magnetic resonance imaging (fMRI). Analysis of variance of Region of Interest signal change revealed a statistically significant effect of the Group-by-Region-by-Condition interaction. This was due to the BPD group exhibiting a significantly larger magnitude of deactivation (relative to HC) in the bilateral rostral/subgenual anterior cingulate cortex (ACC) to fear and in the left ACC to fear minus neutral; and significantly greater activation in the right amygdala to fear minus neutral. There were no significant between-group differences in ROI signal change in response to anger. In voxel-wise analyses constrained within these ROIs, the BPD group exhibited significant changes in the fear minus neutral contrast, with relatively less activation in the bilateral rostral/subgenual ACC, and greater activation in the right amygdala. In the anger minus neutral contrast this pattern was reversed, with the BPD group showing greater activation in the bilateral rostral/subgenual ACC and less activation in the bilateral amygdala. We conclude that adults with BPD exhibit changes in fronto-limbic activity in the processing of fear stimuli, with exaggerated amygdala response and impaired emotion-modulation of ACC activity. The neural substrates underlying processing of anger may also be altered. These changes may represent an expression of the volumetric and serotonergic deficits observed in these brain areas in BPD. PMID:17601709

Fronto-limbic dysfunction in response to facial emotion in borderline personality disorder: an event-related fMRI study.

PubMed

Minzenberg, Michael J; Fan, Jin; New, Antonia S; Tang, Cheuk Y; Siever, Larry J

2007-08-15

Clinical hallmarks of borderline personality disorder (BPD) include social and emotional dysregulation. We tested a model of fronto-limbic dysfunction in facial emotion processing in BPD. Groups of 12 unmedicated adults with BPD by DSM-IV and 12 demographically-matched healthy controls (HC) viewed facial expressions (Conditions) of neutral emotion, fear and anger, and made gender discriminations during rapid event-related functional magnetic resonance imaging (fMRI). Analysis of variance of Region of Interest signal change revealed a statistically significant effect of the Group-by-Region-by-Condition interaction. This was due to the BPD group exhibiting a significantly larger magnitude of deactivation (relative to HC) in the bilateral rostral/subgenual anterior cingulate cortex (ACC) to fear and in the left ACC to fear minus neutral; and significantly greater activation in the right amygdala to fear minus neutral. There were no significant between-group differences in ROI signal change in response to anger. In voxel-wise analyses constrained within these ROIs, the BPD group exhibited significant changes in the fear minus neutral contrast, with relatively less activation in the bilateral rostral/subgenual ACC, and greater activation in the right amygdala. In the anger minus neutral contrast this pattern was reversed, with the BPD group showing greater activation in the bilateral rostral/subgenual ACC and less activation in the bilateral amygdala. We conclude that adults with BPD exhibit changes in fronto-limbic activity in the processing of fear stimuli, with exaggerated amygdala response and impaired emotion-modulation of ACC activity. The neural substrates underlying processing of anger may also be altered. These changes may represent an expression of the volumetric and serotonergic deficits observed in these brain areas in BPD.

Social anxiety and perception of (un)trustworthiness in smiling faces.

PubMed

Gutiérrez-García, Aida; Calvo, Manuel G

2016-10-30

In social environments the smile can be driven by different motives and convey different emotions. This makes a smiling face ambiguous and amenable to alternative interpretations. We investigated how social anxiety is related to trustworthiness evaluation of morphed dynamic smiling faces depending on changes in the eye expression. Socially anxious and non-anxious participants judged the un/trustworthiness of people with different smiles. Social anxiety was related to reduced trustworthiness of (a) faces with a neutral mouth unfolding to a smile when the eyes were neutral at the beginning or end of the dynamic sequence, and (b) faces with a smiling mouth when happy eyes slightly changed towards neutrality, surprise, fear, sadness, disgust, or anger. In contrast, social anxiety was not related to trustworthiness judgments for non-ambiguous expressions unfolding from neutral (eyes and mouth) to happy (eyes and mouth) or from happy to neutral. Socially anxious individuals are characterized by an interpretation bias towards mistrusting any ambiguous smile due to the presence of non-happy eyes. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

Electric force on plasma ions and the momentum of the ion-neutrals flow

NASA Astrophysics Data System (ADS)

Makrinich, G.; Fruchtman, A.; Zoler, D.; Boxman, R. L.

2018-05-01

The electric force on ions in plasma and the momentum flux carried by the mixed ion-neutral flow were measured and found to be equal. The experiment was performed in a direct-current gas discharge of cylindrical geometry with applied radial electric field and axial magnetic field. The unmagnetized plasma ions, neutralized by magnetized electrons, were accelerated radially outward transferring part of the gained momentum to neutrals. Measurements were taken for various argon gas flow rates between 13 and 100 Standard Cubic Centimeter per Minute, for a discharge current of 1.9 A and a magnetic field intensity of 136 G. The plasma density, electron temperature, and plasma potential were measured at various locations along the flow. These measurements were used to determine the local electric force on the ions. The total electric force on the plasma ions was then determined by integrating radially the local electric force. In parallel, the momentum flux of the mixed ion-neutral flow was determined by measuring the force exerted by the flow on a balance force meter (BFM). The maximal plasma density was between 6 × 1010 cm-3 and 5 × 1011 cm-3, the maximal electron temperature was between 8 eV and 25 eV, and the deduced maximal electric field was between 2200 V/m and 5800 V/m. The force exerted by the mixed ion-neutral flow on the BFM agreed with the total electric force on the plasma ions. This agreement showed that it is the electric force on the plasma ions that is the source of the momentum acquired by the mixed ion-neutral flow.

Predicting Treatment Response in Social Anxiety Disorder From Functional Magnetic Resonance Imaging

PubMed Central

Doehrmann, Oliver; Ghosh, Satrajit S.; Polli, Frida E.; Reynolds, Gretchen O.; Horn, Franziska; Keshavan, Anisha; Triantafyllou, Christina; Saygin, Zeynep M.; Whitfield-Gabrieli, Susan; Hofmann, Stefan G.; Pollack, Mark; Gabrieli, John D.

2013-01-01

Context Current behavioral measures poorly predict treatment outcome in social anxiety disorder (SAD). To our knowledge, this is the first study to examine neuroimaging-based treatment prediction in SAD. Objective To measure brain activation in patients with SAD as a biomarker to predict subsequent response to cognitive behavioral therapy (CBT). Design Functional magnetic resonance imaging (fMRI) data were collected prior to CBT intervention. Changes in clinical status were regressed on brain responses and tested for selectivity for social stimuli. Setting Patients were treated with protocol-based CBT at anxiety disorder programs at Boston University or Massachusetts General Hospital and underwent neuroimaging data collection at Massachusetts Institute of Technology. Patients Thirty-nine medication-free patients meeting DSM-IV criteria for the generalized subtype of SAD. Interventions Brain responses to angry vs neutral faces or emotional vs neutral scenes were examined with fMRI prior to initiation of CBT. Main Outcome Measures Whole-brain regression analyses with differential fMRI responses for angry vs neutral faces and changes in Liebowitz Social Anxiety Scale score as the treatment outcome measure. Results Pretreatment responses significantly predicted subsequent treatment outcome of patients selectively for social stimuli and particularly in regions of higher-order visual cortex. Combining the brain measures with information on clinical severity accounted for more than 40% of the variance in treatment response and substantially exceeded predictions based on clinical measures at baseline. Prediction success was unaffected by testing for potential confounding factors such as depression severity at baseline. Conclusions The results suggest that brain imaging can provide biomarkers that substantially improve predictions for the success of cognitive behavioral interventions and more generally suggest that such biomarkers may offer evidence-based, personalized medicine approaches for optimally selecting among treatment options for a patient. PMID:22945462

Dissection of epitope-specific mechanisms of neutralization of influenza virus by intact IgG and Fab fragments.

PubMed

Williams, James A; Gui, Long; Hom, Nancy; Mileant, Alexander; Lee, Kelly K

2017-12-20

The neutralizing antibody (nAb) response against the influenza virus's hemagglutinin (HA) fusion glycoprotein is important for preventing viral infection, but we lack a comprehensive understanding of the mechanisms by which these antibodies act. Here we investigated the effect of nAb binding and the role of IgG bivalency on inhibition of HA function for nAbs targeting distinct HA epitopes. HC19 targets the receptor-binding pocket at HA's distal end, while FI6v3 binds primarily to the HA2 fusion subunit towards the base of the stalk. Surprisingly, HC19 inhibited HA's ability to induce lipid mixing by preventing structural rearrangement of HA under fusion activating conditions. These results suggest that nAbs such as HC19 not only act by blocking receptor binding, but also inhibit key late-stage HA conformational changes required for fusion. Intact HC19 IgG was also shown to crosslink separate virus particles, burying large proportions of HA within aggregates where they are blocked from interacting with target membranes; Fabs yielded no such aggregation and displayed weaker neutralization than IgG, emphasizing the impact of bivalency on the ability to neutralize virus. In contrast, the stem-targeting nAb FI6v3 did not aggregate particles. The Fab was significantly less effective than IgG in preventing both membrane disruption and fusion. We infer that inter-spike crosslinking within a given particle by FI6v3 IgG may be critical to its potent neutralization, as no significant neutralization occurred with Fabs. These results demonstrate that IgG bivalency enhances HA inhibition through functionally important modes not evident in pared down Fab-soluble HA structures. IMPORTANCE The influenza virus's hemagglutinin (HA) fusion glycoprotein mediates entry into target cells and is the primary antigenic target of neutralizing antibodies (nAbs). Our current structural understanding of mechanisms of Ab-mediated neutralization largely relies on high resolution characterization of antigen binding fragments (Fab) in complex with soluble, isolated antigen constructs by cryo-EM single particle reconstruction or X-ray crystallography. Interactions between full-length IgG and whole virions have not been well-characterized, and a gap remains in our understanding of how intact Abs neutralize virus and prevent infection. Using structural and biophysical approaches, we observed that Ab-mediated inhibition of HA function and neutralization of virus infectivity occurs by multiple coexisting mechanisms and is largely dependent on the specific epitope that is targeted and is highly dependent on the bivalent nature of IgG molecules. Copyright © 2017 American Society for Microbiology.

System Description for Tank 241-AZ-101 Waste Retrieval Data Acquisition System

DOE Office of Scientific and Technical Information (OSTI.GOV)

ROMERO, S.G.

2000-02-14

The proposed activity provides the description of the Data Acquisition System for Tank 241-AZ-101. This description is documented in HNF-5572, Tank 241-AZ-101 Waste Retrieval Data Acquisition System (DAS). This activity supports the planned mixer pump tests for Tank 241-AZ-101. Tank 241-AZ-101 has been selected for the first full-scale demonstration of a mixer pump system. The tank currently holds over 960,000 gallons of neutralized current acid waste, including approximately 12.7 inches of settling solids (sludge) at the bottom of the tank. As described in Addendum 4 of the FSAR (LMHC 2000a), two 300 HP mixer pumps with associated measurement and monitoringmore » equipment have been installed in Tank 241-AZ-101. The purpose of the Tank 241-AZ-101 retrieval system Data Acquisition System (DAS) is to provide monitoring and data acquisition of key parameters in order to confirm the effectiveness of the mixer pumps utilized for suspending solids in the tank. The suspension of solids in Tank 241-AZ-101 is necessary for pretreatment of the neutralized current acid waste and eventual disposal as glass via the Hanford Waste Vitrification Plant. HNF-5572 provides a basic description of the Tank 241-AZ-101 retrieval system DAS, including the field instrumentation and application software. The DAS is provided to fulfill requirements for data collection and monitoring. This document is not an operations procedure or is it intended to describe the mixing operation. This USQ screening provides evaluation of HNF-5572 (Revision 1) including the changes as documented on ECN 654001. The changes include (1) add information on historical trending and data backup, (2) modify DAS I/O list in Appendix E to reflect actual conditions in the field, and (3) delete IP address in Appendix F per Lockheed Martin Services, Inc. request.« less

Deterministic processes guide long-term synchronised population dynamics in replicate anaerobic digesters

PubMed Central

Vanwonterghem, Inka; Jensen, Paul D; Dennis, Paul G; Hugenholtz, Philip; Rabaey, Korneel; Tyson, Gene W

2014-01-01

A replicate long-term experiment was conducted using anaerobic digestion (AD) as a model process to determine the relative role of niche and neutral theory on microbial community assembly, and to link community dynamics to system performance. AD is performed by a complex network of microorganisms and process stability relies entirely on the synergistic interactions between populations belonging to different functional guilds. In this study, three independent replicate anaerobic digesters were seeded with the same diverse inoculum, supplied with a model substrate, α-cellulose, and operated for 362 days at a 10-day hydraulic residence time under mesophilic conditions. Selective pressure imposed by the operational conditions and model substrate caused large reproducible changes in community composition including an overall decrease in richness in the first month of operation, followed by synchronised population dynamics that correlated with changes in reactor performance. This included the synchronised emergence and decline of distinct Ruminococcus phylotypes at day 148, and emergence of a Clostridium and Methanosaeta phylotype at day 178, when performance became stable in all reactors. These data suggest that many dynamic functional niches are predictably filled by phylogenetically coherent populations over long time scales. Neutral theory would predict that a complex community with a high degree of recognised functional redundancy would lead to stochastic changes in populations and community divergence over time. We conclude that deterministic processes may play a larger role in microbial community dynamics than currently appreciated, and under controlled conditions it may be possible to reliably predict community structural and functional changes over time. PMID:24739627

Reconfigurable Structure using Multifunctional Mechanized Materials for Threats Precognition and Neutralization

DTIC Science & Technology

2015-09-24

AFRL-AFOSR-VA-TR-2015-0304 Reconfigurable Structure using Multifunctional Mechanized Materials for Threats Precognition and Neutralization Hae Chang...Contract/Grant  Title:   Reconfigurable  Structure  using  Multifunctional  Mechanized  Materials  for  Threats   Precognition  and...using   multifunctional   mechanized   materials   for   threats   precognition   and   neutralization.   The   main   design

Improved Orbit Determination and Forecasts with an Assimilative Tool for Atmospheric Density and Satellite Drag Specification

NASA Astrophysics Data System (ADS)

Crowley, G.; Pilinski, M.; Sutton, E. K.; Codrescu, M.; Fuller-Rowell, T. J.; Matsuo, T.; Fedrizzi, M.; Solomon, S. C.; Qian, L.; Thayer, J. P.

2016-12-01

Much as aircraft are affected by the prevailing winds and weather conditions in which they fly, satellites are affected by the variability in density and motion of the near earth space environment. Drastic changes in the neutral density of the thermosphere, caused by geomagnetic storms or other phenomena, result in perturbations of LEO satellite motions through drag on the satellite surfaces. This can lead to difficulties in locating important satellites, temporarily losing track of satellites, and errors when predicting collisions in space. We describe ongoing work to build a comprehensive nowcast and forecast system for specifying the neutral atmospheric state related to orbital drag conditions. The system outputs include neutral density, winds, temperature, composition, and the satellite drag derived from these parameters. This modeling tool is based on several state-of-the-art coupled models of the thermosphere-ionosphere as well as several empirical models running in real-time and uses assimilative techniques to produce a thermospheric nowcast. This software will also produce 72 hour predictions of the global thermosphere-ionosphere system using the nowcast as the initial condition and using near real-time and predicted space weather data and indices as the inputs. Features of this technique include: • Satellite drag specifications with errors lower than current models • Altitude coverage up to 1000km • Background state representation using both first principles and empirical models • Assimilation of satellite drag and other datatypes • Real time capability • Ability to produce 72-hour forecasts of the atmospheric state In this paper, we will summarize the model design and assimilative architecture, and present preliminary validation results. Validation results will be presented in the context of satellite orbit errors and compared with several leading atmospheric models including the High Accuracy Satellite Drag Model, which is currently used operationally by the Air Force to specify neutral densities. As part of the analysis, we compare the drag observed by a variety of satellites which were not used as part of the assimilation-dataset and whose perigee altitudes span a range from 200km to 700 km.

Time-averaged current analysis of a thunderstorm using ground-based measurements

NASA Astrophysics Data System (ADS)

Driscoll, Kevin T.; Blakeslee, Richard J.; Koshak, William J.

1994-05-01

The amount of upward current provided to the ionosphere by a thunderstorm that appeared over the Kennedy Space Center (KSC) on July 11, 1978, is reexamined using an analytic equation that describes a bipolar thunderstorm's current contribution to the global circuit in terms of its generator current, lightning currents, the altitudes of its charge centers, and the conductivity profile of the atmosphere. Ground-based measurements, which were obtained from a network of electric field mills positioned at various distances from the thunderstorm, were used to characterize the electrical activity inside the thundercloud. The location of the lightning discharges, the type of lightning, and the amount of charge neutralized during this thunderstorm were computed through a least squares inversion of the measured changes in the electric fields following each lightning discharge. These measurements provided the information necessary to implement the analytic equation, and consequently, a time-averaged estimate of this thunderstorm's current contribution to the global circuit was calculated. From these results the amount of conduction current supplied to the ionosphere by this small thunderstorm was computed to be less than 25% of the time-averaged generator current that flowed between the two vertically displaced charge centers.

Enhanced collective focusing of intense neutralized ion beam pulses in the presence of weak solenoidal magnetic fields

DOE PAGES

Dorf, Mikhail A.; Davidson, Ronald C.; Kaganovich, Igor D.; ...

2012-05-31

In this study, the design of ion drivers for warm dense matter and high energy density physics applications and heavy ion fusion involves transverse focusing and longitudinal compression of intense ion beams to a small spot size on the target. To facilitate the process, the compression occurs in a long drift section filled with a dense background plasma, which neutralizes the intense beam self-fields. Typically, the ion bunch charge is better neutralized than its current, and as a result a net self-pinching (magnetic) force is produced. The self-pinching effect is of particular practical importance, and is used in various ionmore » driver designs in order to control the transverse beam envelope. In the present work we demonstrate that this radial self-focusing force can be significantly enhanced if a weak (B~100 G) solenoidal magnetic field is applied inside the neutralized drift section, thus allowing for substantially improved transport. It is shown that in contrast to magnetic self-pinching, the enhanced collective self-focusing has a radial electric field component and occurs as a result of the overcompensation of the beam charge by plasmaelectrons, whereas the beam current becomes well-neutralized. As the beam leaves the neutralizing drift section, additional transverse focusing can be applied. For instance, in the neutralized drift compression experiments (NDCX) a strong (several Tesla) final focus solenoid is used for this purpose. In the present analysis we propose that the tight final focus in the NDCX experiments may possibly be achieved by using a much weaker (few hundred Gauss) magnetic lens, provided the ion beam carries an equal amount of co-moving neutralizing electrons from the preceding drift section into the lens. In this case the enhanced focusing is provided by the collective electrondynamics strongly affected by a weak applied magnetic field.« less

Unraveling Selection in the Mitochondrial Genome of Drosophila

PubMed Central

Ballard, JWO.; Kreitman, M.

1994-01-01

We examine mitochondrial DNA variation at the cytochrome b locus within and between three species of Drosophila to determine whether patterns of variation conform to the predictions of neutral molecular evolution. The entire 1137-bp cytochrome b locus was sequenced in 16 lines of Drosophila melanogaster, 18 lines of Drosophila simulans and 13 lines of Drosophila yakuba. Patterns of variation depart from neutrality by several test criteria. Analysis of the evolutionary clock hypothesis shows unequal rates of change along D. simulans lineages. A comparison within and between species of the ratio of amino acid replacement change to synonymous change reveals a relative excess of amino acid replacement polymorphism compared to the neutral prediction, suggestive of slightly deleterious or diversifying selection. There is evidence for excess homozygosity in our world wide sample of D. melanogaster and D. simulans alleles, as well as a reduction in the number of segregating sites in D. simulans, indicative of selective sweeps. Furthermore, a test of neutrality for codon usage shows the direction of mutations at third positions differs among different topological regions of the gene tree. The analyses indicate that molecular variation and evolution of mtDNA are governed by many of the same selective forces that have been shown to govern nuclear genome evolution and suggest caution be taken in the use of mtDNA as a ``neutral'' molecular marker. PMID:7851772

Phase space effects on fast ion transport modeling in tokamaks

NASA Astrophysics Data System (ADS)

Podesta, Mario

2015-11-01

Simulations of burning plasmas require a consistent treatment of energetic particles (EP), possibly including the effects of instabilities. Reduced EP transport models are emerging as an effective tool to account for those effects in long time-scale simulations. Available models essentially differ for the main transport drive, which is associated to gradients in real or phase space. It is crucial to assess to what extent those different assumptions affect computed quantities such as EP profile, Neutral Beam (NB) driven current and energy/momentum transfer to the thermal populations. These issues are investigated through a kick model, which includes modifications of the EP distribution by instabilities in real and velocity space. TRANSP simulations including the kick model are applied to NB-heated NSTX discharges featuring unstable toroidal Alfvén eigenmodes (TAEs). Results show that TAEs mainly affect fast ions with large parallel velocity, i.e. the most effective for NB current drive. Other portions of the EP distribution are nearly unperturbed. Core NB driven current decreases by 10-30%, with even larger relative changes toward the plasma edge. When TAEs evolve in so-called avalanches, the model reproduces measured drops of ~ 10% in the neutron rate. Consistently with previous results, the drop is caused by both EP energy loss and EP redistribution. These results are compared to those from a simple diffusive model and a ``critical gradient'' model, which postulates radial EP gradient as the only transport drive. The importance of EP velocity space modifications is discussed in terms of accuracy of the predictions, with emphasis on Neutral Beam driven current. Work supported by U.S. DOE Contract DE-AC02-09CH11466.

Neutrino-driven Explosion of a 20 Solar-mass Star in Three Dimensions Enabled by Strange-quark Contributions to Neutrino-Nucleon Scattering

NASA Astrophysics Data System (ADS)

Melson, Tobias; Janka, Hans-Thomas; Bollig, Robert; Hanke, Florian; Marek, Andreas; Müller, Bernhard

2015-08-01

Interactions with neutrons and protons play a crucial role for the neutrino opacity of matter in the supernova core. Their current implementation in many simulation codes, however, is rather schematic and ignores not only modifications for the correlated nuclear medium of the nascent neutron star, but also free-space corrections from nucleon recoil, weak magnetism, or strange quarks, which can easily add up to changes of several 10% for neutrino energies in the spectral peak. In the Garching supernova simulations with the Prometheus-Vertex code, such sophistications have been included for a long time except for the strange-quark contributions to the nucleon spin, which affect neutral-current neutrino scattering. We demonstrate on the basis of a 20 {M}⊙ progenitor star that a moderate strangeness-dependent contribution of {g}{{a}}{{s}}=-0.2 to the axial-vector coupling constant {g}{{a}}≈ 1.26 can turn an unsuccessful three-dimensional (3D) model into a successful explosion. Such a modification is in the direction of current experimental results and reduces the neutral-current scattering opacity of neutrons, which dominate in the medium around and above the neutrinosphere. This leads to increased luminosities and mean energies of all neutrino species and strengthens the neutrino-energy deposition in the heating layer. Higher nonradial kinetic energy in the gain layer signals enhanced buoyancy activity that enables the onset of the explosion at ˜300 ms after bounce, in contrast to the model with vanishing strangeness contributions to neutrino-nucleon scattering. Our results demonstrate the close proximity to explosion of the previously published, unsuccessful 3D models of the Garching group.

Plasma-Neutral Coupling on the Dark and Bright Sides of Antarctica

NASA Astrophysics Data System (ADS)

Chu, X.; Yu, Z.; Fong, W.; Chen, C.; Zhao, J.; Huang, W.; Roberts, B. R.; Fuller-Rowell, T. J.; Richmond, A. D.; Gerrard, A. J.; Weatherwax, A. T.; Gardner, C. S.

2014-12-01

The polar mesosphere and thermosphere provide a unique natural laboratory for studying the complex physical, chemical, neutral dynamical and electrodynamics processes in the Earth's atmosphere and space environment. McMurdo (geographic 77.83S, geomagnetic 80S) is located by the poleward edge of the aurora oval; so energetic particles may penetrate into the lower thermosphere and mesosphere along nearly vertical geomagnetic field lines. Lidar observations at McMurdo from December 2010 to 2014 have discovered several neutral atmosphere phenomena closely related to ionosphereic parameters and geomagnetic activity. For example, the diurnal tidal amplitude of temperatures not only increases super-exponentially from 100 to 110 km but also its growth rate becomes larger at larger Kp index. The lidar discovery of neutral iron (Fe) layers with gravity wave signatures in the thermosphere enabled the direct measurements of neutral temperatures from 30 to 170 km, revealing the neutral-ion coupling and aurora-enhanced Joule heating. A lidar 'marathon' of 174-hour continuous observations showed dramatic changes of composition (Fe atoms and ice particles) densities (over 40 times) in the mesopause region and their correlations to solar events. In this paper we will study the plasma-neutral coupling on the dark side of Antarctica via observation analysis and numerical modeling of the thermospheric Fe layers in the 100-200 km. A newly developed thermospheric Fe/Fe+ model is used to quantify how Fe+ ions are transported from their main deposition region to the E-F region and then neutralized to form Fe layers under dark polar conditions. We will also study the plasma-neutral coupling on the bright side of Antarctica via analyzing Fe events in summer. Complementary observations will be combined to show how the extreme changes of Fe layers are related to aurora particle precipitation and visible/sub-visible ice particles. These observations and studies will open new areas of scientific inquiry regarding the composition, chemistry, neutral dynamics, thermodynamics, and electrodynamics of one of the least-understood regions in the atmosphere.

Inflammatory responses to neutral fat and fatty acids in multiple organs in a rat model of fat embolism syndrome.

PubMed

Takada, Meri; Chiba, Shoetsu; Nagai, Tomonori; Takeshita, Hiroshi; Kanno, Sanae; Ikawa, Toru; Sakamoto, Kana; Sagi, Morihisa; Ichiba, Kazue; Mukai, Toshiji

2015-09-01

Fat embolism syndrome (FES) is a common complication of long bone fractures. FES is rare but with significant morbidity and occasional fatalities. Studies of animal models of FES are numerous; however, few studies compare inflammatory reactions in multiple organs. The present study investigated the effect of neutral fat and fatty acids, which cause changes in multiple organs and induce FES. Using rats we evaluated the ratio of lung-to-body weight and conducted histological analyses and quantitative analysis of inflammatory cytokine mRNAs in the lungs following intravenous administration of neutral fat or fatty acids. Neutral fat increased the ratio of lung-to-body weight, and neutral fat formed emboli in lung capillaries. The levels of interleukin-1 beta (IL-1β), IL-6 and tumor necrosis factor-alpha (TNF-α) in the lungs increased after injection of neutral fat and oleic acid. Analysis of the histologic changes revealed that the highest numbers of fat droplets, occluding the capillaries of the lungs, kidney, heart, and brain formed 12h after the injection of neutral fat and fat droplets gradually diminished 48h later. Fat droplets were not detected in any organs after the injection of oleic acid. IL-1β and TNF-α levels in the lungs were elevated 9-24h after the injection of neutral fat, although IL-6 levels peaked at 6h. After injection of oleic acid, peak levels of IL-1β, IL-6, and TNF-α were detected at 6h, and IL-6 again increased in all organs and plasma at 15h. Neutral fat, but not fatty acids, formed emboli in the capillaries of multiple organs. These findings suggest that neutral fat increased inflammatory cytokine levels by forming emboli in organ capillaries, particularly in the lungs, while oleic acid augmented inflammatory cytokine levels by stimulating endothelial cells of multiple organs. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Global, Energy-Dependent Ring Current Response During Two Large Storms

NASA Astrophysics Data System (ADS)

Goldstein, J.; Angelopoulos, V.; Burch, J. L.; De Pascuale, S.; Fuselier, S. A.; Genestreti, K. J.; Kurth, W. S.; LLera, K.; McComas, D. J.; Reeves, G. D.; Spence, H. E.; Valek, P. W.

2015-12-01

Two recent large (~200 nT) geomagnetic storms occurred during 17--18 March 2015 and 22--23 June 2015. The global, energy-dependent ring current response to these two extreme events is investigated using both global imaging and multi-point in situ observations. Energetic neutral atom (ENA) imaging by the Two Wide-angle Imaging Neutral-atom Spectrometers (TWINS) mission provides a global view of ring current ions. Local measurements are provided by two multi-spacecraft missions. The two Van Allen Probes measure in situ plasma (including ion composition) and fields at ring current and plasmaspheric L values. The recently launched Magnetospheric Multiscale (MMS) comprises four spacecraft that have just begun to measure particles (including ion composition) and fields at outer magnetospheric L-values. We analyze the timing and energetics of the stormtime evolution of ring current ions, both trapped and precipitating, using TWINS ENA images and in situ data by the Van Allen Probes and MMS.

A measurement of the neutral current neutrino-nucleon elastic cross section at MiniBooNE

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cox, David Christopher

2008-02-01

The neutral current neutrino-nucleon elastic interaction v N → v N is a fundamental process of the weak interaction ideally suited for characterizing the structure of the nucleon neutral weak current. This process comprises ~18% of neutrino events in the neutrino oscillation experiment, MiniBooNE, ranking it as the experiment's third largest process. Using ~10% of MiniBooNE's available neutrino data, a sample of these events were identified and analyzed to determine the differential cross section as a function of the momentum transfer of the interaction, Q 2. This is the first measurement of a differential cross section with MiniBooNE data. Frommore » this analysis, a value for the nucleon axial mass M A was extracted to be 1.34 ± 0.25 GeV consistent with previous measurements. The integrated cross section for the Q 2 range 0.189 → 1.13 GeV 2 was calculated to be (8.8 ± 0.6(stat) ± 0.2(syst)) x 10 -40 cm 2.« less

Search for active-sterile neutrino mixing using neutral-current interactions in NOvA

DOE PAGES

Adamson, P.; Aliaga, L.; Ambrose, D.; ...

2017-10-30

Here, we report results from the first search for sterile neutrinos mixing with active neutrinos through a reduction in the rate of neutral-current interactions over a baseline of 810 km between the NOvA detectors. Analyzing a 14-kton detector equivalent exposure of 6.05 × 10 20 protons-on-target in the NuMI beam at Fermilab, we observe 95 neutral-current candidates at the Far Detector compared with 83.5 ± 9.7(stat) ± 9.4(syst) events predicted assuming mixing only occurs between active neutrino species. No evidence for νμ→νs transitions is found. Interpreting these results within a 3+1 model, we place constraints on the mixing angles θ 24more » < 20.8° and θ 34 < 31.2° at the 90% C.L. for 0.05 eV 2 ≤ Δm 41 2 ≤ 0.5 eV 2, the range of mass splittings that produce no significant oscillations over the Near Detector baseline.« less

Measurement of the neutrino-oxygen neutral-current interaction cross section by observing nuclear deexcitation γ rays

NASA Astrophysics Data System (ADS)

Abe, K.; Adam, J.; Aihara, H.; Akiri, T.; Andreopoulos, C.; Aoki, S.; Ariga, A.; Ariga, T.; Assylbekov, S.; Autiero, D.; Barbi, M.; Barker, G. J.; Barr, G.; Bass, M.; Batkiewicz, M.; Bay, F.; Bentham, S. W.; Berardi, V.; Berger, B. E.; Berkman, S.; Bertram, I.; Bhadra, S.; Blaszczyk, F. d. M.; Blondel, A.; Bojechko, C.; Bordoni, S.; Boyd, S. B.; Brailsford, D.; Bravar, A.; Bronner, C.; Buchanan, N.; Calland, R. G.; Caravaca Rodríguez, J.; Cartwright, S. L.; Castillo, R.; Catanesi, M. G.; Cervera, A.; Cherdack, D.; Christodoulou, G.; Clifton, A.; Coleman, J.; Coleman, S. J.; Collazuol, G.; Connolly, K.; Cremonesi, L.; Dabrowska, A.; Danko, I.; Das, R.; Davis, S.; de Perio, P.; De Rosa, G.; Dealtry, T.; Dennis, S. R.; Densham, C.; Dewhurst, D.; Di Lodovico, F.; Di Luise, S.; Drapier, O.; Duboyski, T.; Duffy, K.; Dufour, F.; Dumarchez, J.; Dytman, S.; Dziewiecki, M.; Emery-Schrenk, S.; Ereditato, A.; Escudero, L.; Finch, A. J.; Fiorentini Aguirre, G. A.; Friend, M.; Fujii, Y.; Fukuda, Y.; Furmanski, A. P.; Galymov, V.; Gaudin, A.; Giffin, S.; Giganti, C.; Gilje, K.; Goeldi, D.; Golan, T.; Gomez-Cadenas, J. J.; Gonin, M.; Grant, N.; Gudin, D.; Hadley, D. R.; Haegel, L.; Haesler, A.; Haigh, M. D.; Hamilton, P.; Hansen, D.; Hara, T.; Hartz, M.; Hasegawa, T.; Hastings, N. C.; Hayato, Y.; Hearty, C.; Helmer, R. L.; Hierholzer, M.; Hignight, J.; Hillairet, A.; Himmel, A.; Hiraki, T.; Hirota, S.; Holeczek, J.; Horikawa, S.; Huang, K.; Ichikawa, A. K.; Ieki, K.; Ieva, M.; Ikeda, M.; Imber, J.; Insler, J.; Irvine, T. J.; Ishida, T.; Ishii, T.; Ives, S. J.; Iwai, E.; Iwamoto, K.; Iyogi, K.; Izmaylov, A.; Jacob, A.; Jamieson, B.; Johnson, R. A.; Johnson, S.; Jo, J. H.; Jonsson, P.; Jung, C. K.; Kabirnezhad, M.; Kaboth, A. C.; Kajita, T.; Kakuno, H.; Kameda, J.; Kanazawa, Y.; Karlen, D.; Karpikov, I.; Katori, T.; Kearns, E.; Khabibullin, M.; Khotjantsev, A.; Kielczewska, D.; Kikawa, T.; Kilinski, A.; Kim, J.; King, S.; Kisiel, J.; Kitching, P.; Kobayashi, T.; Koch, L.; Kolaceke, A.; Konaka, A.; Kormos, L. L.; Korzenev, A.; Koseki, K.; Koshio, Y.; Kreslo, I.; Kropp, W.; Kubo, H.; Kudenko, Y.; Kumaratunga, S.; Kurjata, R.; Kutter, T.; Lagoda, J.; Laihem, K.; Lamont, I.; Larkin, E.; Laveder, M.; Lawe, M.; Lazos, M.; Lee, K. P.; Licciardi, C.; Lindner, T.; Lister, C.; Litchfield, R. P.; Longhin, A.; Ludovici, L.; Macaire, M.; Magaletti, L.; Mahn, K.; Malek, M.; Manly, S.; Marino, A. D.; Marteau, J.; Martin, J. F.; Martynenko, S.; Maruyama, T.; Marzec, J.; Mathie, E. L.; Matveev, V.; Mavrokoridis, K.; Mazzucato, E.; McCarthy, M.; McCauley, N.; McFarland, K. S.; McGrew, C.; Mefodiev, A.; Metelko, C.; Mezzetto, M.; Mijakowski, P.; Miller, C. A.; Minamino, A.; Mineev, O.; Mine, S.; Missert, A.; Miura, M.; Monfregola, L.; Moriyama, S.; Mueller, Th. A.; Murakami, A.; Murdoch, M.; Murphy, S.; Myslik, J.; Nagasaki, T.; Nakadaira, T.; Nakahata, M.; Nakai, T.; Nakamura, K.; Nakayama, S.; Nakaya, T.; Nakayoshi, K.; Nantais, C.; Naples, D.; Nielsen, C.; Nirkko, M.; Nishikawa, K.; Nishimura, Y.; Nowak, J.; O'Keeffe, H. M.; Ohta, R.; Okumura, K.; Okusawa, T.; Oryszczak, W.; Oser, S. M.; Ovsyannikova, T.; Owen, R. A.; Oyama, Y.; Palladino, V.; Palomino, J. L.; Paolone, V.; Payne, D.; Pearce, G. F.; Perevozchikov, O.; Perkin, J. D.; Petrov, Y.; Pickard, L.; Pinzon Guerra, E. S.; Pistillo, C.; Plonski, P.; Poplawska, E.; Popov, B.; Posiadala-Zezula, M.; Poutissou, J.-M.; Poutissou, R.; Przewlocki, P.; Quilain, B.; Radicioni, E.; Ratoff, P. N.; Ravonel, M.; Rayner, M. A. M.; Redij, A.; Reeves, M.; Reinherz-Aronis, E.; Riccio, C.; Retiere, F.; Robert, A.; Rodrigues, P. A.; Rojas, P.; Rondio, E.; Roth, S.; Rubbia, A.; Ruterbories, D.; Sacco, R.; Sakashita, K.; Sánchez, F.; Sato, F.; Scantamburlo, E.; Scholberg, K.; Schoppmann, S.; Schwehr, J.; Scott, M.; Seiya, Y.; Sekiguchi, T.; Sekiya, H.; Sgalaberna, D.; Shaker, F.; Shiozawa, M.; Short, S.; Shustrov, Y.; Sinclair, P.; Smith, B.; Smith, R. J.; Smy, M.; Sobczyk, J. T.; Sobel, H.; Sorel, M.; Southwell, L.; Stamoulis, P.; Steinmann, J.; Still, B.; Suda, Y.; Suzuki, A.; Suzuki, K.; Suzuki, S. Y.; Suzuki, Y.; Szeglowski, T.; Tacik, R.; Tada, M.; Takahashi, S.; Takeda, A.; Takeuchi, Y.; Tanaka, H. K.; Tanaka, H. A.; Tanaka, M. M.; Taylor, I. J.; Terhorst, D.; Terri, R.; Thompson, L. F.; Thorley, A.; Tobayama, S.; Toki, W.; Tomura, T.; Totsuka, Y.; Touramanis, C.; Tsukamoto, T.; Tzanov, M.; Uchida, Y.; Ueno, K.; Vacheret, A.; Vagins, M.; Vasseur, G.; Wachala, T.; Waldron, A. V.; Walter, C. W.; Wark, D.; Wascko, M. O.; Weber, A.; Wendell, R.; Wilkes, R. J.; Wilking, M. J.; Wilkinson, C.; Williamson, Z.; Wilson, J. R.; Wilson, R. J.; Wongjirad, T.; Yamada, Y.; Yamamoto, K.; Yanagisawa, C.; Yano, T.; Yen, S.; Yershov, N.; Yokoyama, M.; Yuan, T.; Yu, M.; Zalewska, A.; Zalipska, J.; Zambelli, L.; Zaremba, K.; Ziembicki, M.; Zimmerman, E. D.; Zito, M.; Żmuda, J.; T2K Collaboration

2014-10-01

We report the first measurement of the neutrino-oxygen neutral-current quasielastic (NCQE) cross section. It is obtained by observing nuclear deexcitation γ rays which follow neutrino-oxygen interactions at the Super-Kamiokande water Cherenkov detector. We use T2K data corresponding to 3.01 ×1 020 protons on target. By selecting only events during the T2K beam window and with well-reconstructed vertices in the fiducial volume, the large background rate from natural radioactivity is dramatically reduced. We observe 43 events in the 4-30 MeV reconstructed energy window, compared with an expectation of 51.0, which includes an estimated 16.2 background events. The background is primarily nonquasielastic neutral-current interactions and has only 1.2 events from natural radioactivity. The flux-averaged NCQE cross section we measure is 1.55 ×1 0-38 cm2 with a 68% confidence interval of (1.22 ,2.20 )×1 0-38 cm2 at a median neutrino energy of 630 MeV, compared with the theoretical prediction of 2.01 ×1 0-38 cm2 .

Changing how I feel about the food: experimentally manipulated affective associations with fruits change fruit choice behaviors.

PubMed

Walsh, Erin M; Kiviniemi, Marc T

2014-04-01

Fewer than half of Americans meet current recommendations for fruit and vegetable intake. The behavioral affective associations model posits that feelings and emotions associated with a behavior are a proximal influence on decision making. Cross-sectional evidence supports the model and suggests that affective associations predict fruit and vegetable consumption. The purpose of this study was to test whether a causal relation exists between affective associations about fruits and future fruit consumption behavior, as measured by a snack selection task. Following a baseline assessment of cognitive and affective variables, participants' (N = 161) affective associations about fruits were experimentally manipulated with an implicit priming paradigm. Images of fruits were repeatedly paired with positive, negative, or neutral affective stimuli. The key outcome measure was a behavioral choice task in which participants chose between fruit and a granola bar. Participants in the positive prime condition were three times more likely than those in the negative condition to select a piece of fruit over the granola bar alternative in the snack selection task. They were also twice as likely as those in the neutral condition to select fruit. There were no changes in self-reported affective associations or cognitive beliefs. These findings provide further evidence of the implicit and direct influence of affective associations on behavior, suggesting the need to both incorporate the role of affect in health decision making models, as well as the potential utility of intervention strategies targeting affective associations with health-related behaviors.

Changing how I feel about the food: experimentally manipulated affective associations with fruits change fruit choice behaviors

PubMed Central

Kiviniemi, Marc T.

2013-01-01

Fewer than half of Americans meet current recommendations for fruit and vegetable intake. The behavioral affective associations model posits that feelings and emotions associated with a behavior are a proximal influence on decision making. Cross-sectional evidence supports the model and suggests that affective associations predict fruit and vegetable consumption. The purpose of this study was to test whether a causal relation exists between affective associations about fruits and future fruit consumption behavior, as measured by a snack selection task. Following a baseline assessment of cognitive and affective variables, participants’ (N = 161) affective associations about fruits were experimentally manipulated with an implicit priming paradigm. Images of fruits were repeatedly paired with positive, negative, or neutral affective stimuli. The key outcome measure was a behavioral choice task in which participants chose between fruit and a granola bar. Participants in the positive prime condition were three times more likely than those in the negative condition to select a piece of fruit over the granola bar alternative in the snack selection task. They were also twice as likely as those in the neutral condition to select fruit. There were no changes in self-reported affective associations or cognitive beliefs. These findings provide further evidence of the implicit and direct influence of affective associations on behavior, suggesting the need to both incorporate the role of affect in health decision making models, as well as the potential utility of intervention strategies targeting affective associations with health-related behaviors. PMID:23299831

Solute-solvent interactions and dynamics probed by THz light

NASA Astrophysics Data System (ADS)

Schwaab, Gerhard; Böhm, Fabian; Ma, Chun-Yu; Havenith, Martina

The THz range (1-12 THz, 30-400 cm-1) is especially suited to probe changes in the solvent dynamics induced by solutes of different character (hydrophobic, hydrophilic, charged, neutral). In recent years we have investigated a large variety of such solutes and found characteristic spectral fingerprints for ions, but also for uncharged solutes, such as alcohols. We will present a status report on our current understanding of the observed spectral changes and how they relate to physico-chemical parameters like hydration shell size or the lifetime of an excited intermolecular oscillation. In addition, we will show, that in some cases the spectral changes are closely related to the partition function yielding access to a microscopic understanding of macroscopic thermodynamic functions. The authors gratefully acknowledge financial support from the Cluster of Excellence RESOLV (Ruhr-Universität, EXC1069) funded by the Deutsche Forschungsgemeinschaft.

The impacts of neutralized acid mine drainage contaminated water on the expression of selected endocrine-linked genes in juvenile Mozambique tilapia Oreochromis mossambicus exposed in vivo.

PubMed

Truter, Johannes Christoff; va Wyk, Johannes Hendrik; Oberholster, Paul Johan; Botha, Anna-Maria

2014-02-01

Acid mine drainage (AMD) is a global environmental concern due to detrimental impacts on river ecosystems. Little is however known regarding the biological impacts of neutralized AMD on aquatic vertebrates despite excessive discharge into watercourses. The aim of this investigation was to evaluate the endocrine modulatory potential of neutralized AMD, using molecular biomarkers in the teleost fish Oreochromis mossambicus in exposure studies. Surface water was collected from six locations downstream of a high density sludge (HDS) AMD treatment plant and a reference site unimpacted by AMD. The concentrations of 28 elements, including 22 metals, were quantified in the exposure water in order to identify potential links to altered gene expression. Relatively high concentrations of manganese (~ 10mg/l), nickel (~ 0.1mg/l) and cobalt (~ 0.03 mg/l) were detected downstream of the HDS plant. The expression of thyroid receptor-α (trα), trβ, androgen receptor-1 (ar1), ar2, glucocorticoid receptor-1 (gr1), gr2, mineralocorticoid receptor (mr) and aromatase (cyp19a1b) was quantified in juvenile fish after 48 h exposure. Slight but significant changes were observed in the expression of gr1 and mr in fish exposed to water collected directly downstream of the HDS plant, consisting of approximately 95 percent neutralized AMD. The most pronounced alterations in gene expression (i.e. trα, trβ, gr1, gr2, ar1 and mr) was associated with water collected further downstream at a location with no other apparent contamination vectors apart from the neutralized AMD. The altered gene expression associated with the "downstream" locality coincided with higher concentrations of certain metals relative to the locality adjacent to the HDS plant which may indicate a causative link. The current study provides evidence of endocrine disruptive activity associated with neutralized AMD contamination in regard to alterations in the expression of key genes linked to the thyroid, interrenal and gonadal endocrine axes of a teleost fish species. © 2013 Published by Elsevier Inc.

What, Where, When, Who and How: Accounting for Biogenic CO2 Emissions Fluxes

NASA Astrophysics Data System (ADS)

Ohrel, S. B.

2013-12-01

The world is facing a future with a changing climate as well as increasing energy needs. Many countries, including the United States, are therefore considering an increased role of biomass in domestic energy portfolios. Accounting for emissions related to biomass production and use for energy is a complex issue: determining the extent to which biomass utilization can contribute to meeting energy needs while not contributing additional GHG emissions to the atmosphere necessitates further research. Such analysis becomes more challenging when evaluating biogenic feedstocks with long rotations (i.e., woody biomass). Detailed analysis and new accounting methods are needed in order to better assess and understand the potential implications of increased bioenergy utilization in the United States energy portfolio. In response to the EPA's 2011 Draft Accounting Framework for Biogenic CO2 Emissions from Stationary Sources, the Biogenic Carbon Emissions Panel (BCE Panel) appointed by the Science Advisory Board (2013) found that 'Carbon neutrality cannot be assumed for all biomass energy a priori. There are circumstances in which biomass is grown, harvested and combusted in a carbon neutral fashion but carbon neutrality is not an appropriate a priori assumption; it is a conclusion that should be reached only after considering a particular feedstock's production and consumption cycle. There is considerable heterogeneity in feedstock types, sources and production methods and thus net biogenic carbon emissions will vary considerably.' In that light, this study discusses the current policy discussion on biogenic feedstock use for energy in the United States. It then evaluates the question: how can we account for stationary source biogenic CO2 emissions while considering the biological cycling of carbon on the biogenic feedstock production landscape? The analysis discusses current biogenic feedstock usage in the U.S. and potential future impacts of increased biogenic feedstock production on U.S. land use, supply of non-energy commodities (e.g., timber, food crops), and related GHG emission fluxes. This paper first assesses current methods for accounting for land use sector biogenic CO2 emissions (i.e., IPCC approach). Based on the finding that no current methods exist for linking stationary source emissions with the land producing biogenic feedstocks, a unique method is needed that takes into consideration the biological cycling of carbon when accounting for biogenic emissions from energy use. The paper then describes the key technical and scientific considerations that should be taken in account, such as: the implications of baseline chosen; the important roles of temporal and spatial scales; emissions fluxes during feedstock production as well as transportation, storage and processing; the role of land use management and change, etc. It also discusses how these considerations can vary depending on feedstock type (e.g., long versus short rotation).

Functional Connectivity During Exposure to Favorite-Food, Stress, and Neutral-Relaxing Imagery Differs Between Smokers and Nonsmokers.

PubMed

Garrison, Kathleen A; Sinha, Rajita; Lacadie, Cheryl M; Scheinost, Dustin; Jastreboff, Ania M; Constable, R Todd; Potenza, Marc N

2016-09-01

Tobacco-use disorder is a complex condition involving multiple brain networks and presenting with multiple behavioral correlates including changes in diet and stress. In a previous functional magnetic resonance imaging (fMRI) study of neural responses to favorite-food, stress, and neutral-relaxing imagery, smokers versus nonsmokers demonstrated blunted corticostriatal-limbic responses to favorite-food cues. Based on other recent reports of alterations in functional brain networks in smokers, the current study examined functional connectivity during exposure to favorite-food, stress, and neutral-relaxing imagery in smokers and nonsmokers, using the same dataset. The intrinsic connectivity distribution was measured to identify brain regions that differed in degree of functional connectivity between groups during each imagery condition. Resulting clusters were evaluated for seed-to-voxel connectivity to identify the specific connections that differed between groups during each imagery condition. During exposure to favorite-food imagery, smokers versus nonsmokers showed lower connectivity in the supramarginal gyrus, and differences in connectivity between the supramarginal gyrus and the corticostriatal-limbic system. During exposure to neutral-relaxing imagery, smokers versus nonsmokers showed greater connectivity in the precuneus, and greater connectivity between the precuneus and the posterior insula and rolandic operculum. During exposure to stress imagery, smokers versus nonsmokers showed lower connectivity in the cerebellum. These findings provide data-driven insights into smoking-related alterations in brain functional connectivity patterns related to appetitive, relaxing, and stressful states. This study uses a data-driven approach to demonstrate that smokers and nonsmokers show differential patterns of functional connectivity during guided imagery related to personalized favorite-food, stress, and neutral-relaxing cues, in brain regions implicated in attention, reward-related, emotional, and motivational processes. For smokers, these differences in connectivity may impact appetite, stress, and relaxation, and may interfere with smoking cessation. © The Author 2016. Published by Oxford University Press on behalf of the Society for Research on Nicotine and Tobacco. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Functional Connectivity During Exposure to Favorite-Food, Stress, and Neutral-Relaxing Imagery Differs Between Smokers and Nonsmokers

PubMed Central

Sinha, Rajita; Lacadie, Cheryl M.; Scheinost, Dustin; Jastreboff, Ania M.; Constable, R. Todd; Potenza, Marc N.

2016-01-01

Introduction: Tobacco-use disorder is a complex condition involving multiple brain networks and presenting with multiple behavioral correlates including changes in diet and stress. In a previous functional magnetic resonance imaging (fMRI) study of neural responses to favorite-food, stress, and neutral-relaxing imagery, smokers versus nonsmokers demonstrated blunted corticostriatal-limbic responses to favorite-food cues. Based on other recent reports of alterations in functional brain networks in smokers, the current study examined functional connectivity during exposure to favorite-food, stress, and neutral-relaxing imagery in smokers and nonsmokers, using the same dataset. Methods: The intrinsic connectivity distribution was measured to identify brain regions that differed in degree of functional connectivity between groups during each imagery condition. Resulting clusters were evaluated for seed-to-voxel connectivity to identify the specific connections that differed between groups during each imagery condition. Results: During exposure to favorite-food imagery, smokers versus nonsmokers showed lower connectivity in the supramarginal gyrus, and differences in connectivity between the supramarginal gyrus and the corticostriatal-limbic system. During exposure to neutral-relaxing imagery, smokers versus nonsmokers showed greater connectivity in the precuneus, and greater connectivity between the precuneus and the posterior insula and rolandic operculum. During exposure to stress imagery, smokers versus nonsmokers showed lower connectivity in the cerebellum. Conclusions: These findings provide data-driven insights into smoking-related alterations in brain functional connectivity patterns related to appetitive, relaxing, and stressful states. Implications: This study uses a data-driven approach to demonstrate that smokers and nonsmokers show differential patterns of functional connectivity during guided imagery related to personalized favorite-food, stress, and neutral-relaxing cues, in brain regions implicated in attention, reward-related, emotional, and motivational processes. For smokers, these differences in connectivity may impact appetite, stress, and relaxation, and may interfere with smoking cessation. PMID:26995796

Predominant role of water in regulating the tree-growth response to diurnal asymmetric warmin

NASA Astrophysics Data System (ADS)

Chen, Z.; Xia, J.; Cui, E.

2017-12-01

Growth of the Northern Hemisphere trees is affected by diurnal asymmetric warming, which is generally considered to touch off carbon assimilation and increment of carbon storage. Asymmetric effects of diurnal warming on vegetation greenness were validated in previous researches, however, the effect of diurnal warming on wood tissue which stores most carbon of a whole plant is still unknown. Here, we combined ring-width index (RWI), remote sensing-based normalized difference vegetation index (NDVI) and climate datasets to detect the effects of daytime and night-time warming on vegetation growth, respectively. Our results indicate that daytime warming enhances NDVI but has neutral effect on tree woody growth over the Northern Hemisphere. Response of wood growth to daytime warming is linearly regulated by soil water availability. The underlying mechanism of different response of canopy and wood growth to daytime warming may attribute to the biomass change, that is, allocation to foliage tissues increased at the expense of wood tissue under warming and water-limited conditions. Night-time warming show neutral effects on NDVI and RWI over the Northern Hemisphere, and the neutral Tmin-NDVI correlations result from the non-linear mediation of soil water availability. Our results highlight the current greening trend under daytime warming does not mean higher carbon sink capacity, the warming-drying climate may impair the large carbon sink of global forests.

HdeB chaperone activity is coupled to its intrinsic dynamic properties

PubMed Central

Ding, Jienv; Yang, Chengfeng; Niu, Xiaogang; Hu, Yunfei; Jin, Changwen

2015-01-01

Enteric bacteria encounter extreme acidity when passing through hosts’ stomach. Since the bacterial periplasmic space quickly equilibrates with outer environment, an efficient acid resistance mechanism is essential in preventing irreversible protein denaturation/aggregation and maintaining bacteria viability. HdeB, along with its homolog HdeA, was identified as a periplasmic acid-resistant chaperone. Both proteins exist as homodimers and share similar monomeric structures under neutral pH, while showing different dimeric packing interfaces. Previous investigations show that HdeA functions through an acid-induced dimer-to-monomer transition and partial unfolding at low pH (pH 2–3), resulting in exposure of hydrophobic surfaces that bind substrate proteins. In contrast, HdeB appears to have a much higher optimal activation pH (pH 4–5), under which condition the protein maintains a well-folded dimer and the mechanism for its chaperone activity remains elusive. Herein, we present an NMR study of HdeB to investigate its dynamic properties. Our results reveal that HdeB undergoes significant micro- to milli-second timescale conformational exchanges at neutral to near-neutral pH, under the later condition it exhibits optimal activity. The current study indicates that HdeB activation is coupled to its intrinsic dynamics instead of structural changes, and therefore its functional mechanism is apparently different from HdeA. PMID:26593705

Quantum-chemical studies on the favored and rare tautomers of neutral and redox adenine.

PubMed

Raczyńska, Ewa D; Makowski, Mariusz; Zientara-Rytter, Katarzyna; Kolczyńska, Katarzyna; Stępniewski, Tomasz M; Hallmann, Małgorzata

2013-02-21

All possible twenty-three prototropic tautomers of neutral and redox adenine (nine amine and fourteen imine forms, including geometric isomerism of the exo ═NH group) were examined in vacuo {DFT(B3LYP)/6-311+G(d,p)}. The NH → NH conversions as well as those usually omitted, NH → CH and CH → CH, were considered. An interesting change of the tautomeric preference occurs when proceeding from neutral to reduced adenine. One-electron reduction favors the nonaromatic amine C8H-N10H tautomer. This tautomeric preference is similar to that (C2H) for reduced imidazole. Water molecules (PCM model) seem to not change this trend. They influence solely the relative energies. The DFT vertical detachment energy in the gas phase is positive for each tautomer, e.g., 0.03 eV for N9H-N10H and 1.84 eV for C8H-N10H. The DFT adiabatic electron affinity for the favored process, neutral N9H-N10H → reduced C8H-N10H (ground states), is equal to 0.18 eV at 0 K (ZPE included). One-electron oxidation does not change the tautomeric preference in the gas phase. The aromatic amine N9H-N10H tautomer is favored for the oxidized molecule similarly as for the neutral one. The DFT adiabatic ionization potential for the favored process, neutral N9H-N10H → oxidized N9H-N10H (ground states), is equal to 8.12 eV at 0 K (ZPE included). Water molecules (PCM model) seem to influence solely the composition of the tautomeric mixture and the relative energies. They change the energies of the oxidation and reduction processes by ca. 2 eV.

Development of data acquisition and over-current protection systems for a suppressor-grid current with a neutral-beam ion source

NASA Astrophysics Data System (ADS)

Wei, LIU; Chundong, HU; Sheng, LIU; Shihua, SONG; Jinxin, WANG; Yan, WANG; Yuanzhe, ZHAO; Lizhen, LIANG

2017-12-01

Neutral beam injection is one of the effective auxiliary heating methods in magnetic-confinement-fusion experiments. In order to acquire the suppressor-grid current signal and avoid the grid being damaged by overheating, a data acquisition and over-current protection system based on the PXI (PCI eXtensions for Instrumentation) platform has been developed. The system consists of a current sensor, data acquisition module and over-current protection module. In the data acquisition module, the acquired data of one shot will be transferred in isolation and saved in a data-storage server in a txt file. It can also be recalled using NBWave for future analysis. The over-current protection module contains two modes: remote and local. This gives it the function of setting a threshold voltage remotely and locally, and the forbidden time of over-current protection also can be set by a host PC in remote mode. Experimental results demonstrate that the data acquisition and over-current protection system has the advantages of setting forbidden time and isolation transmission.

Continuing Development of a Hybrid Model (VSH) of the Neutral Thermosphere

NASA Technical Reports Server (NTRS)

Burns, Alan

1996-01-01

We propose to continue the development of a new operational model of neutral thermospheric density, composition, temperatures and winds to improve current engineering environment definitions of the neutral thermosphere. This model will be based on simulations made with the National Center for Atmospheric Research (NCAR) Thermosphere-Ionosphere- Electrodynamic General Circulation Model (TIEGCM) and on empirical data. It will be capable of using real-time geophysical indices or data from ground-based and satellite inputs and provides neutral variables at specified locations and times. This "hybrid" model will be based on a Vector Spherical Harmonic (VSH) analysis technique developed (over the last 8 years) at the University of Michigan that permits the incorporation of the TIGCM outputs and data into the model. The VSH model will be a more accurate version of existing models of the neutral thermospheric, and will thus improve density specification for satellites flying in low Earth orbit (LEO).

The effect of emotion on interpretation and logic in a conditional reasoning task.

PubMed

Blanchette, Isabelle

2006-07-01

The effect of emotional content on logical reasoning is explored in three experiments. Theparticipants completed a conditional reasoning task (If p, then q) with emotional and neutral contents. In Experiment 1, existing emotional and neutral words were used. The emotional value of initially neutral words was experimentally manipulated in Experiments 1B and 2, using classical conditioning. In all experiments, participants were less likely to provide normatively correct answers when reasoning about emotional stimuli, compared with neutral stimuli. This was true for both negative (Experiments 1B and 2) and positive contents (Experiment 2). The participants' interpretations of the conditional statements were also measured (perceived sufficiency, necessity, causality, and plausibility). The results showed the expected relationship between interpretation and reasoning. However, emotion did not affect interpretation. Emotional and neutral conditional statements were interpreted similarly. The results are discussed in light of current models of emotion and reasoning.

In vivo emergence of HIV-1 highly sensitive to neutralizing antibodies.

PubMed

Aasa-Chapman, Marlén M I; Cheney, Kelly M; Hué, Stéphane; Forsman, Anna; O'Farrell, Stephen; Pellegrino, Pierre; Williams, Ian; McKnight, Áine

2011-01-01

The rapid and continual viral escape from neutralizing antibodies is well documented in HIV-1 infection. Here we report in vivo emergence of viruses with heightened sensitivity to neutralizing antibodies, sometimes paralleling the development of neutralization escape. Sequential viral envs were amplified from seven HIV-1 infected men monitored from seroconversion up to 5 years after infection. Env-recombinant infectious molecular clones were generated and tested for coreceptor use, macrophage tropism and neutralization sensitivity to homologous and heterologous serum, soluble CD4 and monoclonal antibodies IgG1b12, 2G12 and 17b. We found that HIV-1 evolves sensitivity to contemporaneous neutralizing antibodies during infection. Neutralization sensitive viruses grow out even when potent autologous neutralizing antibodies are present in patient serum. Increased sensitivity to neutralization was associated with susceptibility of the CD4 binding site or epitopes induced after CD4 binding, and mediated by complex envelope determinants including V3 and V4 residues. The development of neutralization sensitive viruses occurred without clinical progression, coreceptor switch or change in tropism for primary macrophages. We propose that an interplay of selective forces for greater virus replication efficiency without the need to resist neutralizing antibodies in a compartment protected from immune surveillance may explain the temporal course described here for the in vivo emergence of HIV-1 isolates with high sensitivity to neutralizing antibodies.

Brain responses to verbal stimuli among multiple sclerosis patients with pseudobulbar affect.

PubMed

Haiman, Guy; Pratt, Hillel; Miller, Ariel

2008-08-15

To characterize the brain activity and associated cortical structures involved in pseudobulbar affect (PBA), a condition characterized by uncontrollable episodes of emotional lability in patients with multiple sclerosis (MS). Behavioral responses and event related potentials (ERP) in response to subjectively significant and neutral verbal stimuli were recorded from 33 subjects in 3 groups: 1) MS patients with PBA (MS+PBA); 2) MS patients without PBA (MS); 3) Healthy control subjects (HC). Statistical non-parametric mapping comparisons of ERP source current density distributions between groups were conducted separately for subjectively significant and for neutral stimuli. Behavioral responses showed more impulsive performance in patients with PBA. As expected, almost all ERP waveform comparisons between the MS groups and controls were significant. Source analysis indicated significantly distinct activation in MS+PBA in the vicinity of the somatosensory and motor areas in response to neutral stimuli, and at pre-motor and supplementary motor areas in response to subjectively significant stimuli. Both subjectively significant and neutral stimuli evoked higher current density in MS+PBA compared to both other groups. PBA of MS patients involves cortical structures related to sensory-motor and emotional processing, in addition to overactive involvement of motor cortical areas in response to neutral stimuli. These results may suggest that a 'disinhibition' of a "gate control"-type mechanism for emotional expression may lead to the lower emotional expression threshold of pseudobulbar affect.

Transport in a field-aligned magnetized plasma and neutral gas boundary: the end of the plasma

NASA Astrophysics Data System (ADS)

Cooper, Christopher; Gekelman, Walter

2012-10-01

A series of experiments at the Enormous Toroidal Plasma Device (ETPD) at UCLA study the Neutral Boundary Layer (NBL) between a magnetized plasma and a neutral gas in the direction of the confining field. A lanthanum hexaboride (LaB6) cathode and semi-transparent anode create a current-free, weakly ionized (ne/nn<5%), helium plasma (B˜250 G, Rplasma=10cm, ne<10^12cm^3, Te<3eV, and Ti˜Tn) that terminates on helium gas without touching any walls. Probes inserted into the plasma measure the basic plasma parameters in the NBL. The NBL begins where the plasma and neutral gas pressures equilibrate and the electrons and ions come to rest through collisions with the neutral gas. A field-aligned electric field (δφ/kTe˜1) is established self-consistently to maintain a current-free termination and dominates transport in the NBL, similar to a sheath but with a length L˜10λei˜10^2λen˜10^5λD. A two-fluid weakly-ionized transport model describes the system. A generalized Ohm's Law correctly predicts the electric field observed. The pressure balance criteria and magnitude of the termination electric field are confirmed over a scaling of parameters. The model can also be used to describe the atmospheric termination of aurora or fully detached gaseous divertors.

Evidence for task conflict in the Stroop effect.

PubMed

Goldfarb, Liat; Henik, Avishai

2007-10-01

C. M. MacLeod and P. A. MacDonald (2000) suggested that congruent and incongruent Stroop stimuli cause more task conflict than neutral stimuli because the anterior cingulate cortex is more activated with these stimuli. This study investigated behavioral expression for this pattern. Experiment 1 reduced task conflict control by increasing the proportion of nonword neutrals. Additionally, half the trials had conflict or neutral cues. The control reduction revealed the task conflict. For noncued trials, response time was longer for congruent stimuli than for neutral stimuli (reverse facilitation effect). In addition, response time for congruent stimuli was longer when stimuli were uncued vs. cued. Experiment 2 increased task conflict control by changing the neutral stimuli to noncolor words. Consequently, the task conflict expression disappeared. (c) 2007 APA

Quantum Monte Carlo calculation of neutral-current ν -12C inclusive quasielastic scattering

NASA Astrophysics Data System (ADS)

Lovato, A.; Gandolfi, S.; Carlson, J.; Lusk, Ewing; Pieper, Steven C.; Schiavilla, R.

2018-02-01

Quasielastic neutrino scattering is an important aspect of the experimental program to study fundamental neutrino properties including neutrino masses, mixing angles, mass hierarchy, and charge-conjugation parity (CP)- violating phase. Proper interpretation of the experiments requires reliable theoretical calculations of neutrino-nucleus scattering. In this paper we present calculations of response functions and cross sections by neutral-current scattering of neutrinos off 12C. These calculations are based on realistic treatments of nuclear interactions and currents, the latter including the axial, vector, and vector-axial interference terms crucial for determining the difference between neutrino and antineutrino scattering and the CP-violating phase. We find that the strength and energy dependence of two-nucleon processes induced by correlation effects and interaction currents are crucial in providing the most accurate description of neutrino-nucleus scattering in the quasielastic regime.

Differentiation among Multiple Sources of Anthropogenic Nitrate in a Complex Groundwater System using Dual Isotope Systematics: A case study from Mortandad Canyon, New Mexico

NASA Astrophysics Data System (ADS)

Larson, T. E.; Perkins, G.; Longmire, P.; Heikoop, J. M.; Fessenden, J. E.; Rearick, M.; Fabyrka-Martin, J.; Chrystal, A. E.; Dale, M.; Simmons, A. M.

2009-12-01

The groundwater system beneath Los Alamos National Laboratory has been affected by multiple sources of anthropogenic nitrate contamination. Average NO3-N concentrations of up to 18.2±1.7 mg/L have been found in wells in the perched intermediate aquifer beneath one of the more affected sites within Mortandad Canyon. Sources of nitrate potentially reaching the alluvial and intermediate aquifers include: (1) sewage effluent, (2) neutralized nitric acid, (3) neutralized 15N-depleted nitric acid (treated waste from an experiment enriching nitric acid in 15N), and (4) natural background nitrate. Each of these sources is unique in δ18O and δ15N space. Using nitrate stable isotope ratios, a mixing model for the three anthropogenic sources of nitrate was established, after applying a linear subtraction of the background component. The spatial and temporal variability in nitrate contaminant sources through Mortandad Canyon is clearly shown in ternary plots. While microbial denitrification has been shown to change groundwater nitrate stable isotope ratios in other settings, the redox potential, relatively high dissolved oxygen content, increasing nitrate concentrations over time, and lack of observed NO2 in these wells suggest minimal changes to the stable isotope ratios have occurred. Temporal trends indicate that the earliest form of anthropogenic nitrate in this watershed was neutralized nitric acid. Alluvial wells preserve a trend of decreasing nitrate concentrations and mixing models show decreasing contributions of 15N-depleted nitric acid. Nearby intermediate wells show increasing nitrate concentrations and mixing models indicate a larger component derived from 15N-depleted nitric acid. These data indicate that the pulse of neutralized 15N-depleted nitric acid that was released into Mortandad Canyon between 1986 and 1989 has infiltrated through the alluvial aquifer and is currently affecting two intermediate wells. This hypothesis is consistent with previous research suggesting that the perched intermediate aquifers in the Mortandad Canyon watershed are recharged locally from the overlying alluvial aquifers.

Efficient acceleration of neutral atoms in laser produced plasma

DOE PAGES

Dalui, M.; Trivikram, T. M.; Colgan, James Patrick; ...

2017-06-20

Recent advances in high-intensity laser-produced plasmas have demonstrated their potential as compact charge particle accelerators. Unlike conventional accelerators, transient quasi-static charge separation acceleration fields in laser produced plasmas are highly localized and orders of magnitude larger. Manipulating these ion accelerators, to convert the fast ions to neutral atoms with little change in momentum, transform these to a bright source of MeV atoms. The emittance of the neutral atom beam would be similar to that expected for an ion beam. Since intense laser-produced plasmas have been demonstrated to produce high-brightness-low-emittance beams, it is possible to envisage generation of high-flux, low-emittance, highmore » energy neutral atom beams in length scales of less than a millimeter. Here, we show a scheme where more than 80% of the fast ions are reduced to energetic neutral atoms and demonstrate the feasibility of a high energy neutral atom accelerator that could significantly impact applications in neutral atom lithography and diagnostics.« less

Correlation between solar flare productivity and photospheric vector magnetic fields

NASA Astrophysics Data System (ADS)

Cui, Yanmei; Wang, Huaning

2008-11-01

Studying the statistical correlation between the solar flare productivity and photospheric magnetic fields is very important and necessary. It is helpful to set up a practical flare forecast model based on magnetic properties and improve the physical understanding of solar flare eruptions. In the previous study ([Cui, Y.M., Li, R., Zhang, L.Y., He, Y.L., Wang, H.N. Correlation between solar flare productivity and photospheric magnetic field properties 1. Maximum horizontal gradient, length of neutral line, number of singular points. Sol. Phys. 237, 45 59, 2006]; from now on we refer to this paper as ‘Paper I’), three measures of the maximum horizontal gradient, the length of the neutral line, and the number of singular points are computed from 23990 SOHO/MDI longitudinal magnetograms. The statistical relationship between the solar flare productivity and these three measures is well fitted with sigmoid functions. In the current work, the three measures of the length of strong-shear neutral line, total unsigned current, and total unsigned current helicity are computed from 1353 vector magnetograms observed at Huairou Solar Observing Station. The relationship between the solar flare productivity and the current three measures can also be well fitted with sigmoid functions. These results are expected to be beneficial to future operational flare forecasting models.

New insights into flavivirus biology: the influence of pH over interactions between prM and E proteins

NASA Astrophysics Data System (ADS)

Oliveira, Edson R. A.; de Alencastro, Ricardo B.; Horta, Bruno A. C.

2017-11-01

Diseases caused by flaviviruses, such as dengue and zika, are globally recognized as major threats. During infection, a critical point in their replicative cycle is the maturation step, which occurs throughout the cellular exocytic pathway. This step is a pH-dependent process that involves the modification of the viral envelope by converting prM (pre-membrane) into M (membrane) proteins with the release of a "pr peptide". After this reaction, the pr peptides remain bound to the viral envelope while the virions cross the acidic trans-Golgi network, and are released only at neutral pH after secretion of the virus particles. Despite this current knowledge, the molecular basis of the flavivirus maturation step is largely unknown. Here, based on the crystal structure of the dengue pr-E complex ("pr peptide" bound to virus envelope protein) and using molecular dynamics simulations, we found that the pH shift from acidic to neutral yields considerable structural changes in the system. Dynamic cross correlation maps and root mean square deviation analyses revealed that the pr-E junction is clearly unstable under neutral pH. Secondary structure analysis also revealed that the fusion loop region, present in the E protein, is sensitive to pH and tends to unstructure at a neutral environment. Moreover, we found that five residues present in the E protein, Gly102, His244, Thr70, Thr68 and Asn67 are critical to confer stability to the pr-E complex while inside the Golgi apparatus. This work brings details about the dynamical behavior of the pr-E system, helps to better understand the flavivirus biology and may also be of use in the development of novel antiviral strategies.

The Big Picture: Imaging of the Global Geospace Environment by the TWINS Mission

NASA Astrophysics Data System (ADS)

Goldstein, J.; McComas, D. J.

2018-03-01

Encircling our planet at distances of 2.5 to 8 Earth radii is a dynamic plasma population known as the ring current (RC). During geomagnetic storms, the solar wind's interaction with Earth's magnetic field pumps petaJoules of energy into the RC, energizing and transporting particles. To measure the global geospace response, RC imaging is performed by capturing energetic neutral atoms (ENAs) created by charge exchange between geospace ions and the neutral exosphere. The H exosphere is itself imaged via its geocoronal Lyman-α glow. Two Wide-angle Imaging Neutral-atom Spectrometers (TWINS) is a stereoscopic ENA and Lyman-α imaging mission that has recorded the deep minimum of solar cycle (SC) 23 and the moderate maximum of SC 24, observing geospace conditions ranging from utterly quiet to major storms. This review covers TWINS studies of the geospace response published during 2013 to 2017. Stereo ENA imaging has revealed new dimensionality and structure of RC ions. Continuous coverage by two imagers has allowed monitoring storms from start to finish. Deconvolution of the low-altitude signal has extended ENA analysis and revealed causal connections between the trapped and precipitating ion populations. ENA-based temperature and composition analyses have been refined, validated, and applied to an unprecedented sequence of solar activity changes in SC 23 and SC 24. Geocoronal imaging has revealed a surprising amount of time variability and structure in the neutral H exosphere, driven by both Sun and solar wind. Global models have been measurably improved. Routine availability of simultaneous in situ measurements has fostered huge leaps forward in the areas of ENA validation and cross-scale studies.

Neutralizer Hollow Cathode Simulations and Comparisons with Ground Test Data

NASA Technical Reports Server (NTRS)

Mikellides, Ioannis G.; Snyder, John S.; Goebel, Dan M.; Katz, Ira; Herman, Daniel A.

2009-01-01

The fidelity of electric propulsion physics-based models depends largely on the validity of their predictions over a range of operating conditions and geometries. In general, increased complexity of the physics requires more extensive comparisons with laboratory data to identify the region(s) that lie outside the validity of the model assumptions and to quantify the uncertainties within its range of application. This paper presents numerical simulations of neutralizer hollow cathodes at various operating conditions and orifice sizes. The simulations were performed using a two-dimensional axisymmetric model that solves numerically a relatively extensive system of conservation laws for the partially ionized gas in these devices. A summary of the comparisons between simulation results and Langmuir probe measurements is provided. The model has also been employed to provide insight into recent ground test observations of the neutralizer cathode in NEXT. It is found that a likely cause of the observed keeper voltage drop is cathode orifice erosion. However, due to the small magnitude of this change, is approx. 0.5 V (less than 5% of the beginning-of-life value) over 10 khrs, and in light of the large uncertainties of the cathode material sputtering yield at low ion energies, other causes cannot be excluded. Preliminary simulations to understand transition to plume mode suggest that in the range of 3-5 sccm the existing 2-D model reproduces fairly well the rise of the keeper voltage in the NEXT neutralizer as observed in the laboratory. At lower flow rates the simulation produces oscillations in the keeper current and voltage that require prohibitively small time-steps to resolve with the existing algorithms.

High degree of correlation between Ebola virus BSL-4 neutralization assays and pseudotyped VSV BSL-2 fluorescence reduction neutralization test.

PubMed

Konduru, Krishnamurthy; Shurtleff, Amy C; Bavari, Sina; Kaplan, Gerardo

2018-04-01

Ebola virus (EBOV), classified as a category A agent by the CDC and NIH, requires BSL-4 containment and induces high morbidity and mortality in humans. The 2013-2015 epidemic in West Africa underscored the urgent need to develop vaccines and therapeutics to prevent and treat EBOV disease. Neutralization assays are needed to evaluate the efficacy of EBOV vaccines and antibody therapies. Pseudotyped viruses based on nonpathogenic or attenuated vectors reduce the risks involved in the evaluation of neutralizing antibodies against highly pathogenic viruses. Selectable markers, fluorescent proteins, and luciferase have been introduced into pseudotyped viruses for detection and quantitation purposes. The current study describes the development of a BSL-2 fluorescence reduction neutralization test (FRNT) using a recombinant vesicular stomatitis virus (VSV) in which the VSV-G envelope gene was replaced with the EBOV glycoprotein (GP) and green fluorescent protein (GFP) genes (rVSV-EBOVgp-GFP). Cells infected with rVSV-EBOVgp-GFP express GFP. Anti-GP neutralizing monoclonal and polyclonal antibodies blocked rVSV-EBOVgp-GFP infection preventing or reducing GFP fluorescence. The high degree of correlation between the EBOV BSL-2 FRNT and the BSL-4 plaque reduction neutralization test (PRNT), the accepted standard of EBOV neutralization tests, supports the use of the EBOV BSL-2 FRNT to evaluate neutralizing antibodies in clinical trials. Published by Elsevier B.V.

Investigating the Fundamentals of Molecular Depth Profiling Using Strong-field Photoionization of Sputtered Neutrals

PubMed Central

Willingham, D.; Brenes, D. A.; Winograd, N.; Wucher, A.

2010-01-01

Molecular depth profiles of model organic thin films were performed using a 40 keV C60+ cluster ion source in concert with TOF-SIMS. Strong-field photoionization of intact neutral molecules sputtered by 40 keV C60+ primary ions was used to analyze changes in the chemical environment of the guanine thin films as a function of ion fluence. Direct comparison of the secondary ion and neutral components of the molecular depth profiles yields valuable information about chemical damage accumulation as well as changes in the molecular ionization probability. An analytical protocol based on the erosion dynamics model is developed and evaluated using guanine and trehalose molecular secondary ion signals with and without comparable laser photoionization data. PMID:26269660

Current structure and flow pattern on the electron separatrix in reconnection region

NASA Astrophysics Data System (ADS)

Guo, Ruilong; Pu, Zuyin; Wei, Yong

2017-12-01

Results from 2.5D Particle-in-cell (PIC) simulations of symmetric reconnection with negligible guide field reveal that the accessible boundary of the electrons accelerated in the magnetic reconnection region is displayed by enhanced electron nongyrotropy downstream from the X-line. The boundary, hereafter termed the electron separatrix, occurs at a few d e (electron inertial length) away from the exhaust side of the magnetic separatrix. On the inflow side of the electron separatrix, the current is mainly carried by parallel accelerated electrons, served as the inflow region patch of the Hall current. The out-of-plane current density enhances at the electron separatrix. The dominating current carriers are the electrons, nongyrotropic distribution functions of which contribute significantly to the perpendicular electron velocity by increasing the electron diamagnetic drift velocity. When crossing the separatrix region where the Hall electric field is enhanced, electron velocity orientation is changed dramatically, which could be a diagnostic indicator to detect the electron separatrix. In the exhaust region, ions are the main carriers for the out-of-plane current, while the parallel current is still mainly carried by electrons. The current density peak in the separatrix region implies that a thin current sheet is formed apart from the neutral line, which can evolve to the bifurcated current sheet.

Clover-Tagged Porcine Reproductive and Respiratory Syndrome Virus Infectious Clones for Rapid Detection of Virus Neutralizing Antibodies.

PubMed

Huang, Baicheng; Xiao, Xia; Xue, Biyun; Zhou, En-Min

2018-06-24

Porcine reproductive and respiratory syndrome (PRRS), caused by the PRRS virus (PRRSV), is a widespread disease that affects domestic pigs of all ages. Accurate and rapid detection of PRRSV specific neutralizing antibodies levels in a pig herd is beneficial for the evaluation of the herd's immunity to combat the specific viral infection. However, the current methods for viral detection, including fluorescent focus neutralization (FFN) and cytopathic effect (CPE) reduction neutralizing assays, are subjective and time-consuming. Therefore, a Clover-tagged PRRSV virus neutralization assay were developed that instrumentally measures the fluorescence signal of Clover stably expressing by a PRRSV infectious clone for at least 10 passages. Herein, the results showed that the proposed Clover-tagged PRRSV neutralization assay is reliable using instrumental measurements of the fluorescence signal of Clover and allows for rapid detection of neutralizing antibodies against PRRSV. The assay was evaluated by testing swine sera from experimental and field samples, and comparisons were made with the traditional FFN and CPE reduction assays. These results suggest that the Clover-tagged PRRSV infectious clone offers a fast and reliable testing method for neutralizing antibodies and could permit high-throughput screening of new antiviral agents. Copyright © 2018. Published by Elsevier B.V.

Shifting species interactions in terrestrial dryland ecosystems under altered water availability and climate change.

PubMed

McCluney, Kevin E; Belnap, Jayne; Collins, Scott L; González, Angélica L; Hagen, Elizabeth M; Nathaniel Holland, J; Kotler, Burt P; Maestre, Fernando T; Smith, Stanley D; Wolf, Blair O

2012-08-01

Species interactions play key roles in linking the responses of populations, communities, and ecosystems to environmental change. For instance, species interactions are an important determinant of the complexity of changes in trophic biomass with variation in resources. Water resources are a major driver of terrestrial ecology and climate change is expected to greatly alter the distribution of this critical resource. While previous studies have documented strong effects of global environmental change on species interactions in general, responses can vary from region to region. Dryland ecosystems occupy more than one-third of the Earth's land mass, are greatly affected by changes in water availability, and are predicted to be hotspots of climate change. Thus, it is imperative to understand the effects of environmental change on these globally significant ecosystems. Here, we review studies of the responses of population-level plant-plant, plant-herbivore, and predator-prey interactions to changes in water availability in dryland environments in order to develop new hypotheses and predictions to guide future research. To help explain patterns of interaction outcomes, we developed a conceptual model that views interaction outcomes as shifting between (1) competition and facilitation (plant-plant), (2) herbivory, neutralism, or mutualism (plant-herbivore), or (3) neutralism and predation (predator-prey), as water availability crosses physiological, behavioural, or population-density thresholds. We link our conceptual model to hypothetical scenarios of current and future water availability to make testable predictions about the influence of changes in water availability on species interactions. We also examine potential implications of our conceptual model for the relative importance of top-down effects and the linearity of patterns of change in trophic biomass with changes in water availability. Finally, we highlight key research needs and some possible broader impacts of our findings. Overall, we hope to stimulate and guide future research that links changes in water availability to patterns of species interactions and the dynamics of populations and communities in dryland ecosystems. © 2011 The Authors. Biological Reviews © 2011 Cambridge Philosophical Society.

Microwave plasma source for neutral-beam injection systems

NASA Astrophysics Data System (ADS)

1981-08-01

The overall program is described and the technical and programmatic reasons for the decision to pursue both the RFI and ECH sources into the current hydrogen test stage is discussed. The general characteristics of plasma sources in the parameter regime of interest for neutral beam applications are considered. The operational characteristics, advantages and potential problems of RFI and ECH sources are discussed.

Updating Existing Emotional Memories Involves the Frontopolar/Orbito-frontal Cortex in Ways that Acquiring New Emotional Memories Does Not

ERIC Educational Resources Information Center

Sakaki, Michiko; Niki, Kazuhisa; Mather, Mara

2011-01-01

In life, we must often learn new associations to people, places, or things we already know. The current fMRI study investigated the neural mechanisms underlying emotional memory updating. Nineteen participants first viewed negative and neutral pictures and learned associations between those pictures and other neutral stimuli, such as neutral…

One-dimensional models of quasi-neutral parallel electric fields

NASA Technical Reports Server (NTRS)

Stern, D. P.

1981-01-01

Parallel electric fields can exist in the magnetic mirror geometry of auroral field lines if they conform to the quasineutral equilibrium solutions. Results on quasi-neutral equilibria and on double layer discontinuities were reviewed and the effects on such equilibria due to non-unique solutions, potential barriers and field aligned current flows using as inputs monoenergetic isotropic distribution functions were examined.

Hepatitis C Virus Evasion Mechanisms from Neutralizing Antibodies

PubMed Central

Di Lorenzo, Caterina; Angus, Allan G. N.; Patel, Arvind H.

2011-01-01

Hepatitis C virus (HCV) represents a major public health problem, affecting 3% of the world’s population. The majority of infected individuals develop chronic hepatitis, which can progress to cirrhosis and hepatocellular carcinoma. To date, a vaccine is not available and current therapy is limited by resistance, adverse effects and high costs. Although it is very well established that cell-mediated immunity is necessary for viral clearance, the importance of host antibodies in clearing HCV infection is being increasingly recognized. Indeed, recent studies indicate that neutralizing antibodies are induced in the early phase of infection by patients who subsequently clear viral infection. Conversely, patients who do not clear the virus develop high titers of neutralizing antibodies during the chronic stage. Surprisingly, these antibodies are not able to control HCV infection. HCV has therefore developed mechanisms to evade immune elimination, allowing it to persist in the majority of infected individuals. A detailed understanding of the mechanisms by which the virus escapes immune surveillance is therefore necessary if novel preventive and therapeutic treatments have to be designed. This review summarizes the current knowledge of the mechanisms used by HCV to evade host neutralizing antibodies. PMID:22163345

Structure of Rotavirus Outer-Layer Protein VP7 Bound with a Neutralizing Fab

DOE Office of Scientific and Technical Information (OSTI.GOV)

Aoki, Scott T.; Settembre, Ethan C.; Trask, Shane D.

2009-06-17

Rotavirus outer-layer protein VP7 is a principal target of protective antibodies. Removal of free calcium ions (Ca{sup 2+}) dissociates VP7 trimers into monomers, releasing VP7 from the virion, and initiates penetration-inducing conformational changes in the other outer-layer protein, VP4. We report the crystal structure at 3.4 angstrom resolution of VP7 bound with the Fab fragment of a neutralizing monoclonal antibody. The Fab binds across the outer surface of the intersubunit contact, which contains two Ca{sup 2+} sites. Mutations that escape neutralization by other antibodies suggest that the same region bears the epitopes of most neutralizing antibodies. The monovalent Fab ismore » sufficient to neutralize infectivity. We propose that neutralizing antibodies against VP7 act by stabilizing the trimer, thereby inhibiting the uncoating trigger for VP4 rearrangement. A disulfide-linked trimer is a potential subunit immunogen.« less

Engineering cyanobacteria for fuels and chemicals production.

PubMed

Zhou, Jie; Li, Yin

2010-03-01

The world's energy and global warming crises call for sustainable, renewable, carbon-neutral alternatives to replace fossil fuel resources. Currently, most biofuels are produced from agricultural crops and residues, which lead to concerns about food security and land shortage. Compared to the current biofuel production system, cyanobacteria, as autotrophic prokaryotes, do not require arable land and can grow to high densities by efficiently using solar energy, CO(2), water, and inorganic nutrients. Moreover, powerful genetic techniques of cyanobacteria have been developed. For these reasons, cyanobacteria, which carry out oxygenic photosynthesis, are attractive hosts for production of fuels and chemicals. Recently, several chemicals including ethanol, isobutanol and isoprene have been produced by engineered cyanobacteria directly using solar energy, CO(2), and water. Cyanobacterium is therefore a potential novel cell factory for fuels and chemicals production to address global energy security and climate change issues.

ExoCube INMS with Neutral Hydrogen Mode

NASA Astrophysics Data System (ADS)

Jones, S.; Paschalidis, N.; Rodriguez, M.; Sittler, E. C., Jr.; Chornay, D. J.; Cameron, T.; Uribe, P.; Nanan, G.; Noto, J.; Waldrop, L.; Mierkiewicz, E. J.; Gardner, D.; Nossal, S. M.; Puig-Suari, J.; Bellardo, J.

2015-12-01

The ExoCube mission launched on Jan 31 2015 into a polar orbit to acquire global knowledge of in situ densities of neutral and ionized H, He, and O in the upper ionosphere and lower exosphere. The CubeSat platform is used in combination with incoherent scatter radar and optical ground stations distributed throughout the Americas. ExoCube seeks to obtain the first in situ measurement of neutral exospheric hydrogen and will measure in situ atomic oxygen for the first time in decades. The compact Ion and Neutral Mass Spectrometer (INMS) developed by GSFC uses the gated Time of Flight technique for in situ measurements of ions and neutrals (H, He, N, O, N2, O2) with M/dM of approximately 10. The compact sensor has a dual symmetric configuration with ion and neutral sensor heads. Neutral particles are ionized by electron impact using a thermionic emitter. In situ measurements of neutral hydrogen are notoriously difficult as historically the signal has been contaminated by hydrogen outgassing which persists even years after commissioning. In order to obtain neutral atmospheric hydrogen fluxes, either the atmospheric peak and outgassing peak must be well resolved, or the outgassing component subtracted off. The ExoCube INMS employs a separate mode, specifically for measuring neutral Hydrogen. The details of this mode and lessons learned will be presented as well as in flight instrument validation data for the neutral channel and preliminary flight ion spectra. At the time of abstract submission, the ExoCube spacecraft is currently undergoing attitude control maneuvers to orient INMS in the ram direction for science operations.

Cross-tail current, field-aligned current, and B(y)

NASA Technical Reports Server (NTRS)

Kaufmann, Richard L.; Lu, Chen; Larson, Douglas J.

1994-01-01

Orbits of individual charged particles were traced in a one-dimensional magnetic field model that included a uniform cross-tail component B(sub yo). The effects of B(sub yo) on the cross-tail current distribution j(sub y)(z), the average cross-tail drift velocity(nu(sub y)z), and the average pitch angle change(delta alpha) experienced during current sheet encounters were calculated. The addition of a B(sub yo) that exceeded several tenths of one nanotesla completely eliminated all resonance effects for odd-N orbits. An odd-N resonance involves ions that enter and exit the current sheet on the same side. Pitch angles of nearly all such ions changed substantially during a typical current sheet interaction, and there was no region of large cross-tail drift velocity in the presence of a modest B(sub yo). the addition of a very large B(sub yo) guide field in the direction that enhances the natural drift produces a large j(y) and small (Delta alpha) for ions with all energies. The addition of a modest B(sub yo) had less effect near even-N resonances. In this case, ions in a small energy range were found to undergo so little change in pitch angle that particles which originated in the ionosphere would pass through the current sheet and return to the conjugate ionosphere. Finally, the cross-tail drift of ions from regions dominated by stochastic orbits to regions dominated by either resonant or guiding center orbits was considered. The ion drift speed changed substantially during such transitions. The accompanying electrons obey the guiding center equations, so electron drift is more uniform. Any difference between gradients in the fluxes associated with electron and ion drifts requires the presence of a Birkeland current in order to maintain charge neutrality. This plasma sheet region therefore serves as a current generator. The analysis predicts that the resulting Birkeland current connects to the lowest altitude equatorial regions in which ions drift to or from a point at which stochastic orbits predominate. The proposed mechanism appears only in analyses that include non-guiding-center effects.

Effects of neutral gas releases on electron beam injection from electrically tethered spacecraft

NASA Technical Reports Server (NTRS)

Winglee, R. M.

1990-01-01

The presence of high neutral densities at low altitudes and/or during thruster firings is known to modify the spacecraft potential during active electron beam injection. Two-dimensional (three velocity) particle simulations are used to investigate the ionization processes including the neutral density required, the modification of the spacecraft potential, beam profile and spatial distribution of the return current into the spacecraft. Three processes are identified: (1) beam-induced ionization, (2) vehicle-induced ionization, and (3) beam plasma discharge. Only in the first two cases does the beam propagate away with little distortion.

Serologic evidence of Lyssavirus infections among bats, the Philippines.

PubMed

Arguin, Paul M; Murray-Lillibridge, Kristy; Miranda, Mary E G; Smith, Jean S; Calaor, Alan B; Rupprecht, Charles E

2002-03-01

Active surveillance for lyssaviruses was conducted among populations of bats in the Philippines. The presence of past or current Lyssavirus infection was determined by use of direct fluorescent antibody assays on bat brains and virus neutralization assays on bat sera. Although no bats were found to have active infection with a Lyssavirus, 22 had evidence of neutralizing antibody against the Australian bat lyssavirus (ABLV). Seropositivity was statistically associated with one species of bat, Miniopterus schreibersi. Results from the virus neutralization assays are consistent with the presence in the Philippines of a naturally occurring Lyssavirus related to ABLV.

Serologic Evidence of Lyssavirus Infections among Bats, the Philippines

PubMed Central

Murray-Lillibridge, Kristy; Miranda, Mary E.G.; Smith, Jean S.; Calaor, Alan B.; Rupprecht, Charles E.

2002-01-01

Active surveillance for lyssaviruses was conducted among populations of bats in the Philippines. The presence of past or current Lyssavirus infection was determined by use of direct fluorescent antibody assays on bat brains and virus neutralization assays on bat sera. Although no bats were found to have active infection with a Lyssavirus, 22 had evidence of neutralizing antibody against the Australian bat lyssavirus (ABLV). Seropositivity was statistically associated with one species of bat, Miniopterus schreibersi. Results from the virus neutralization assays are consistent with the presence in the Philippines of a naturally occurring Lyssavirus related to ABLV. PMID:11927022

Simulations of space charge neutralization in a magnetized electron cooler

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gerity, James; McIntyre, Peter M.; Bruhwiler, David Leslie

Magnetized electron cooling at relativistic energies and Ampere scale current is essential to achieve the proposed ion luminosities in a future electron-ion collider (EIC). Neutralization of the space charge in such a cooler can significantly increase the magnetized dynamic friction and, hence, the cooling rate. The Warp framework is being used to simulate magnetized electron beam dynamics during and after the build-up of neutralizing ions, via ionization of residual gas in the cooler. The design follows previous experiments at Fermilab as a verification case. We also discuss the relevance to EIC designs.

Viper and cobra venom neutralization by beta-sitosterol and stigmasterol isolated from the root extract of Pluchea indica Less. (Asteraceae).

PubMed

Gomes, A; Saha, Archita; Chatterjee, Ipshita; Chakravarty, A K

2007-09-01

We reported previously that the methanolic root extract of the Indian medicinal plant Pluchea indica Less. (Asteraceae) could neutralize viper venom-induced action [Alam, M.I., Auddy, B., Gomes, A., 1996. Viper venom neutralization by Indian medicinal plant (Hemidesmus indicus and P. indica) root extracts. Phytother. Res. 10, 58-61]. The present study reports the neutralization of viper and cobra venom by beta-sitosterol and stigmasterol isolated from the root extract of P. indica Less. (Asteraceae). The active fraction (containing the major compound beta-sitosterol and the minor compound stigmasterol) was isolated and purified by silica gel column chromatography and the structure was determined using spectroscopic analysis (EIMS, (1)H NMR, (13)C NMR). Anti-snake venom activity was studied in experimental animals. The active fraction was found to significantly neutralize viper venom-induced lethal, hemorrhagic, defibrinogenation, edema and PLA(2) activity. Cobra venom-induced lethality, cardiotoxicity, neurotoxicity, respiratory changes and PLA(2) activity were also antagonized by the active component. It potentiated commercial snake venom antiserum action against venom-induced lethality in male albino mice. The active fraction could antagonize venom-induced changes in lipid peroxidation and superoxide dismutase activity. This study suggests that beta-sitosterol and stigmasterol may play an important role, along with antiserum, in neutralizing snake venom-induced actions.

Does patient position influence the reading of the bispectral index monitor?

PubMed

Kaki, Abdullah M; Almarakbi, Waleed A

2009-12-01

Bispectral index (BIS) was developed to monitor patients' level of consciousness under general anesthesia. Several factors have been found to alter BIS readings without affecting the depth of anesthesia. We conducted a study to assess the impact of changing patients' position on BIS readings. General anesthesia was administered to 40 patients undergoing minor surgeries. Patients were kept in neutral position (supine) for 15 min and BIS readings, mean arterial blood pressure, heart rate, end-tidal carbon dioxide, and end-tidal isoflurane were recorded. Patients were then shifted to head-down position (30 degrees), neutral position, and lastly head-up position (30 degrees) each of 15-min duration and the data were recorded. There was a significant increase in BIS values in head-down position (median 47 vs 40) compared with neutral position, whereas head-up position significantly decreased BIS (39 vs 41) compared with neutral position (P < 0.05). Changing a patient's position significantly affects the BIS values, which might affect the interpretation of anesthetic depth.

The effect of music on corticospinal excitability is related to the perceived emotion: a transcranial magnetic stimulation study.

PubMed

Giovannelli, Fabio; Banfi, Chiara; Borgheresi, Alessandra; Fiori, Elisa; Innocenti, Iglis; Rossi, Simone; Zaccara, Gaetano; Viggiano, Maria Pia; Cincotta, Massimo

2013-03-01

Transcranial magnetic stimulation (TMS) and neuroimaging studies suggest a functional link between the emotion-related brain areas and the motor system. It is not well understood, however, whether the motor cortex activity is modulated by specific emotions experienced during music listening. In 23 healthy volunteers, we recorded the motor evoked potentials (MEP) following TMS to investigate the corticospinal excitability while subjects listened to music pieces evoking different emotions (happiness, sadness, fear, and displeasure), an emotionally neutral piece, and a control stimulus (musical scale). Quality and intensity of emotions were previously rated in an additional group of 30 healthy subjects. Fear-related music significantly increased the MEP size compared to the neutral piece and the control stimulus. This effect was not seen with music inducing other emotional experiences and was not related to changes in autonomic variables (respiration rate, heart rate). Current data indicate that also in a musical context, the excitability of the corticomotoneuronal system is related to the emotion expressed by the listened piece. Copyright © 2012 Elsevier Ltd. All rights reserved.

Theoretical constraints on masses of heavy particles in Left-Right symmetric models

NASA Astrophysics Data System (ADS)

Chakrabortty, J.; Gluza, J.; Jeliński, T.; Srivastava, T.

2016-08-01

Left-Right symmetric models with general gL ≠gR gauge couplings which include bidoublet and triplet scalar multiplets are studied. Possible scalar mass spectra are outlined by imposing Tree-Unitarity, and Vacuum Stability criteria and also using the bounds on neutral scalar masses MHFCNC which assure the absence of Flavour Changing Neutral Currents (FCNC). We are focusing on mass spectra relevant for the LHC analysis, i.e., the scalar masses are around TeV scale. As all non-standard heavy particle masses are related to the vacuum expectation value (VEV) of the right-handed triplet (vR), the combined effects of relevant Higgs potential parameters and MHFCNC regulate the lower limits of heavy gauge boson masses. The complete set of Renormalization Group Evolutions for all couplings are provided at the 1-loop level, including the mixing effects in the Yukawa sector. Most of the scalar couplings suffer from the Landau poles at the intermediate scale Q ∼106.5 GeV, which in general coincides with violation of the Tree-Unitarity bounds.

Influence of pHo on calcium channel block by amlodipine, a charged dihydropyridine compound. Implications for location of the dihydropyridine receptor

PubMed Central

1989-01-01

We have investigated the modulation of L-type calcium channel currents in isolated ventricular cells by the dihydropyridine derivative amlodipine, a weak base with a pKa of 8.6. Under conditions that favor neutral drug molecules, amlodipine block resembles other, previously described, neutral dihydropyridine derivatives: block is more pronounced at depolarized voltages, repetitive pulsing is not needed to promote block, and recovery is complete at hyperpolarized voltages. When the drug is ionized, depolarized voltages still enhance block, however, the time course is slow and speeded by repetitive pulses that open channels. Recovery from block by ionized drug molecules is very slow and incomplete, but can be rapidly modified by changes in external hydrogen ion concentration. We conclude from these observations that the degree of ionization of the drug molecule can affect access to the dihydropyridine receptor and that external protons can interact with the drug-receptor complex even if channels are blocked and closed. These observations place limitations on the location of this receptor in the ventricular cell membrane. PMID:2549176

A soft x-ray coronal mass ejection occurred on solar limb on 1998 April 23

NASA Astrophysics Data System (ADS)

Cheng, X. J.

2001-11-01

Using some data observed with SXT/HXT aboard Yohkoh and the Nobeyama Radioheliograph (NoRH) on 1998 April 23, a comprehensive study on the soft X-ray coronal mass ejection (CME) on solar SE limb shows there were two magnetic dipole sources (MDSs), one magnetic capacity belt (MCB) between MDSs, one neutral current sheet (NCS) and only a few activation sources (ASs). During the MCB was changed by the ASs into a magnetic energy belt (MEB), the material and energy both concentrated to the NCS in the course of its formation. When the MDSs were put through by the MEB, the NCS formed and the CME occurred. The matter ejected not only from the NCS, but also from the whole MEB. The expanding loop of the CME had two footprints, they were just the MDSs. The head of the expanding loop always tended to the foot point of weak source. The locus of the head was just neutral line. From this, the position of NCS also could be determined.

Fast-ion transport in qmin>2, high- β steady-state scenarios on DIII-D

DOE PAGES

Holcomb, C. T.; Heidbrink, W. W.; Ferron, J. R.; ...

2015-05-22

The results from experiments on DIII-D [J. L. Luxon, Fusion Sci. Technol. 48, 828 (2005)] aimed at developing high β steady-state operating scenarios with high-qminqmin confirm that fast-ion transport is a critical issue for advanced tokamak development using neutral beam injection current drive. In DIII-D, greater than 11 MW of neutral beam heating power is applied with the intent of maximizing β N and the noninductive current drive. However, in scenarios with q min>2 that target the typical range of q 95= 5–7 used in next-step steady-state reactor models, Alfvén eigenmodes cause greater fast-ion transport than classical models predict. Thismore » enhanced transport reduces the absorbed neutral beam heating power and current drive and limits the achievable β N. Conversely similar plasmas except with q min just above 1 have approximately classical fast-ion transport. Experiments that take q min>3 plasmas to higher β P with q 95= 11–12 for testing long pulse operation exhibit regimes of better than expected thermal confinement. Compared to the standard high-q min scenario, the high β P cases have shorter slowing-down time and lower ∇β fast, and this reduces the drive for Alfvénic modes, yielding nearly classical fast-ion transport, high values of normalized confinement, β N, and noninductive current fraction. These results suggest DIII-D might obtain better performance in lower-q 95, high-q min plasmas using broader neutral beam heating profiles and increased direct electron heating power to lower the drive for Alfvén eigenmodes.« less

Fast-ion transport in q{sub min}>2, high-β steady-state scenarios on DIII-D

DOE Office of Scientific and Technical Information (OSTI.GOV)

Holcomb, C. T.; Heidbrink, W. W.; Collins, C.

2015-05-15

Results from experiments on DIII-D [J. L. Luxon, Fusion Sci. Technol. 48, 828 (2005)] aimed at developing high β steady-state operating scenarios with high-q{sub min} confirm that fast-ion transport is a critical issue for advanced tokamak development using neutral beam injection current drive. In DIII-D, greater than 11 MW of neutral beam heating power is applied with the intent of maximizing β{sub N} and the noninductive current drive. However, in scenarios with q{sub min}>2 that target the typical range of q{sub 95}= 5–7 used in next-step steady-state reactor models, Alfvén eigenmodes cause greater fast-ion transport than classical models predict. Thismore » enhanced transport reduces the absorbed neutral beam heating power and current drive and limits the achievable β{sub N}. In contrast, similar plasmas except with q{sub min} just above 1 have approximately classical fast-ion transport. Experiments that take q{sub min}>3 plasmas to higher β{sub P} with q{sub 95}= 11–12 for testing long pulse operation exhibit regimes of better than expected thermal confinement. Compared to the standard high-q{sub min} scenario, the high β{sub P} cases have shorter slowing-down time and lower ∇β{sub fast}, and this reduces the drive for Alfvénic modes, yielding nearly classical fast-ion transport, high values of normalized confinement, β{sub N}, and noninductive current fraction. These results suggest DIII-D might obtain better performance in lower-q{sub 95}, high-q{sub min} plasmas using broader neutral beam heating profiles and increased direct electron heating power to lower the drive for Alfvén eigenmodes.« less

Neutralization Serotyping of BK Polyomavirus Infection in Kidney Transplant Recipients

PubMed Central

Pastrana, Diana V.; Brennan, Daniel C.; Çuburu, Nicolas; Storch, Gregory A.; Viscidi, Raphael P.; Randhawa, Parmjeet S.; Buck, Christopher B.

2012-01-01

BK polyomavirus (BKV or BKPyV) associated nephropathy affects up to 10% of kidney transplant recipients (KTRs). BKV isolates are categorized into four genotypes. It is currently unclear whether the four genotypes are also serotypes. To address this issue, we developed high-throughput serological assays based on antibody-mediated neutralization of BKV genotype I and IV reporter vectors (pseudoviruses). Neutralization-based testing of sera from mice immunized with BKV-I or BKV-IV virus-like particles (VLPs) or sera from naturally infected human subjects revealed that BKV-I specific serum antibodies are poorly neutralizing against BKV-IV and vice versa. The fact that BKV-I and BKV-IV are distinct serotypes was less evident in traditional VLP-based ELISAs. BKV-I and BKV-IV neutralization assays were used to examine BKV type-specific neutralizing antibody responses in KTRs at various time points after transplantation. At study entry, sera from 5% and 49% of KTRs showed no detectable neutralizing activity for BKV-I or BKV-IV neutralization, respectively. By one year after transplantation, all KTRs were neutralization seropositive for BKV-I, and 43% of the initially BKV-IV seronegative subjects showed evidence of acute seroconversion for BKV-IV neutralization. The results suggest a model in which BKV-IV-specific seroconversion reflects a de novo BKV-IV infection in KTRs who initially lack protective antibody responses capable of neutralizing genotype IV BKVs. If this model is correct, it suggests that pre-vaccinating prospective KTRs with a multivalent VLP-based vaccine against all BKV serotypes, or administration of BKV-neutralizing antibodies, might offer protection against graft loss or dysfunction due to BKV associated nephropathy. PMID:22511874

Incomplete Neutralization and Deviation from Sigmoidal Neutralization Curves for HIV Broadly Neutralizing Monoclonal Antibodies

PubMed Central

McCoy, Laura E.; Falkowska, Emilia; Doores, Katie J.; Le, Khoa; Sok, Devin; van Gils, Marit J.; Euler, Zelda; Burger, Judith A.; Seaman, Michael S.; Sanders, Rogier W.; Schuitemaker, Hanneke; Poignard, Pascal; Wrin, Terri; Burton, Dennis R.

2015-01-01

The broadly neutralizing HIV monoclonal antibodies (bnMAbs) PG9, PG16, PGT151, and PGT152 have been shown earlier to occasionally display an unusual virus neutralization profile with a non-sigmoidal slope and a plateau at <100% neutralization. In the current study, we were interested in determining the extent of non-sigmoidal slopes and plateaus at <100% for HIV bnMAbs more generally. Using both a 278 panel of pseudoviruses in a CD4 T-cell (U87.CCR5.CXCR4) assay and a panel of 117 viruses in the TZM-bl assay, we found that bnMAbs targeting many neutralizing epitopes of the spike had neutralization profiles for at least one virus that plateaued at <90%. Across both panels the bnMAbs targeting the V2 apex of Env and gp41 were most likely to show neutralization curves that plateaued <100%. Conversely, bnMAbs targeting the high-mannose patch epitopes were less likely to show such behavior. Two CD4 binding site (CD4bs) Abs also showed this behavior relatively infrequently. The phenomenon of incomplete neutralization was also observed in a large peripheral blood mononuclear cells (PBMC)-grown molecular virus clone panel derived from patient viral swarms. In addition, five bnMAbs were compared against an 18-virus panel of molecular clones produced in 293T cells and PBMCs and assayed in TZM-bl cells. Examples of plateaus <90% were seen with both types of virus production with no consistent patterns observed. In conclusion, incomplete neutralization and non-sigmoidal neutralization curves are possible for all HIV bnMAbs against a wide range of viruses produced and assayed in both cell lines and primary cells with implications for the use of antibodies in therapy and as tools for vaccine design. PMID:26267277

Incomplete Neutralization and Deviation from Sigmoidal Neutralization Curves for HIV Broadly Neutralizing Monoclonal Antibodies.

PubMed

McCoy, Laura E; Falkowska, Emilia; Doores, Katie J; Le, Khoa; Sok, Devin; van Gils, Marit J; Euler, Zelda; Burger, Judith A; Seaman, Michael S; Sanders, Rogier W; Schuitemaker, Hanneke; Poignard, Pascal; Wrin, Terri; Burton, Dennis R

2015-08-01

The broadly neutralizing HIV monoclonal antibodies (bnMAbs) PG9, PG16, PGT151, and PGT152 have been shown earlier to occasionally display an unusual virus neutralization profile with a non-sigmoidal slope and a plateau at <100% neutralization. In the current study, we were interested in determining the extent of non-sigmoidal slopes and plateaus at <100% for HIV bnMAbs more generally. Using both a 278 panel of pseudoviruses in a CD4 T-cell (U87.CCR5.CXCR4) assay and a panel of 117 viruses in the TZM-bl assay, we found that bnMAbs targeting many neutralizing epitopes of the spike had neutralization profiles for at least one virus that plateaued at <90%. Across both panels the bnMAbs targeting the V2 apex of Env and gp41 were most likely to show neutralization curves that plateaued <100%. Conversely, bnMAbs targeting the high-mannose patch epitopes were less likely to show such behavior. Two CD4 binding site (CD4bs) Abs also showed this behavior relatively infrequently. The phenomenon of incomplete neutralization was also observed in a large peripheral blood mononuclear cells (PBMC)-grown molecular virus clone panel derived from patient viral swarms. In addition, five bnMAbs were compared against an 18-virus panel of molecular clones produced in 293T cells and PBMCs and assayed in TZM-bl cells. Examples of plateaus <90% were seen with both types of virus production with no consistent patterns observed. In conclusion, incomplete neutralization and non-sigmoidal neutralization curves are possible for all HIV bnMAbs against a wide range of viruses produced and assayed in both cell lines and primary cells with implications for the use of antibodies in therapy and as tools for vaccine design.

Soil microbial community responses to acid exposure and neutralization treatment.

PubMed

Shin, Doyun; Lee, Yunho; Park, Jeonghyun; Moon, Hee Sun; Hyun, Sung Pil

2017-12-15

Changes in microbial community induced by acid shock were studied in the context of potential release of acids to the environment due to chemical accidents. The responses of microbial communities in three different soils to the exposure to sulfuric or hydrofluoric acid and to the subsequent neutralization treatment were investigated as functions of acid concentration and exposure time by using 16S-rRNA gene based pyrosequencing and DGGE (Denaturing Gradient Gel Electrophoresis). Measurements of soil pH and dissolved ion concentrations revealed that the added acids were neutralized to different degrees, depending on the mineral composition and soil texture. Hydrofluoric acid was more effectively neutralized by the soils, compared with sulfuric acid at the same normality. Gram-negative ß-Proteobacteria were shown to be the most acid-sensitive bacterial strains, while spore-forming Gram-positive Bacilli were the most acid-tolerant. The results of this study suggest that the Gram-positive to Gram-negative bacterial ratio may serve as an effective bio-indicator in assessing the impact of the acid shock on the microbial community. Neutralization treatments helped recover the ratio closer to their original values. The findings of this study show that microbial community changes as well as geochemical changes such as pH and dissolved ion concentrations need to be considered in estimating the impact of an acid spill, in selecting an optimal remediation strategy, and in deciding when to end remedial actions at the acid spill impacted site. Copyright © 2017 Elsevier Ltd. All rights reserved.

Theoretical analysis of co-solvent effect on the proton transfer reaction of glycine in a water-acetonitrile mixture

NASA Astrophysics Data System (ADS)

Kasai, Yukako; Yoshida, Norio; Nakano, Haruyuki

2015-05-01

The co-solvent effect on the proton transfer reaction of glycine in a water-acetonitrile mixture was examined using the reference interaction-site model self-consistent field theory. The free energy profiles of the proton transfer reaction of glycine between the carboxyl oxygen and amino nitrogen were computed in a water-acetonitrile mixture solvent at various molar fractions. Two types of reactions, the intramolecular proton transfer and water-mediated proton transfer, were considered. In both types of the reactions, a similar tendency was observed. In the pure water solvent, the zwitterionic form, where the carboxyl oxygen is deprotonated while the amino nitrogen is protonated, is more stable than the neutral form. The reaction free energy is -10.6 kcal mol-1. On the other hand, in the pure acetonitrile solvent, glycine takes only the neutral form. The reaction free energy from the neutral to zwitterionic form gradually increases with increasing acetonitrile concentration, and in an equally mixed solvent, the zwitterionic and neutral forms are almost isoenergetic, with a difference of only 0.3 kcal mol-1. The free energy component analysis based on the thermodynamic cycle of the reaction also revealed that the free energy change of the neutral form is insensitive to the change of solvent environment but the zwitterionic form shows drastic changes. In particular, the excess chemical potential, one of the components of the solvation free energy, is dominant and contributes to the stabilization of the zwitterionic form.

30 CFR 75.824 - Electrical protection.

Code of Federal Regulations, 2010 CFR

2010-07-01

... transformer and over-current relay in the neutral grounding resistor circuit. (vi) A single window-type current transformer that encircles all three-phase conductors must be used to activate the ground-fault... current transformer. (vii) A test circuit for the ground-fault device must be provided. The test circuit...

30 CFR 75.824 - Electrical protection.

Code of Federal Regulations, 2012 CFR

2012-07-01

... transformer and over-current relay in the neutral grounding resistor circuit. (vi) A single window-type current transformer that encircles all three-phase conductors must be used to activate the ground-fault... current transformer. (vii) A test circuit for the ground-fault device must be provided. The test circuit...

30 CFR 75.824 - Electrical protection.

Code of Federal Regulations, 2014 CFR

2014-07-01

... transformer and over-current relay in the neutral grounding resistor circuit. (vi) A single window-type current transformer that encircles all three-phase conductors must be used to activate the ground-fault... current transformer. (vii) A test circuit for the ground-fault device must be provided. The test circuit...

30 CFR 75.824 - Electrical protection.

Code of Federal Regulations, 2011 CFR

2011-07-01

... transformer and over-current relay in the neutral grounding resistor circuit. (vi) A single window-type current transformer that encircles all three-phase conductors must be used to activate the ground-fault... current transformer. (vii) A test circuit for the ground-fault device must be provided. The test circuit...

30 CFR 75.824 - Electrical protection.

Code of Federal Regulations, 2013 CFR

2013-07-01

... transformer and over-current relay in the neutral grounding resistor circuit. (vi) A single window-type current transformer that encircles all three-phase conductors must be used to activate the ground-fault... current transformer. (vii) A test circuit for the ground-fault device must be provided. The test circuit...

Optimization of microelectrophoresis to select highly negatively charged sperm.

PubMed

Simon, Luke; Murphy, Kristin; Aston, Kenneth I; Emery, Benjamin R; Hotaling, James M; Carrell, Douglas T

2016-06-01

The sperm membrane undergoes extensive surface remodeling as it matures in the epididymis. During this process, the sperm is encapsulated in an extensive glycocalyx layer, which provides the membrane with its characteristic negative electrostatic charge. In this study, we develop a method of microelectrophoresis and standardize the protocol to isolate sperm with high negative membrane charge. Under an electric field, the percentage of positively charged sperm (PCS), negatively charged sperm (NCS), and neutrally charged sperm was determined for each ejaculate prior to and following density gradient centrifugation (DGC), and evaluated for sperm DNA damage, and histone retention. Subsequently, PCS, NCS, and neutrally charged sperm were selected using an ICSI needle and directly analyzed for DNA damage. When raw semen was analyzed using microelectrophoresis, 94 % were NCS. In contrast, DGC completely or partially stripped the negative membrane charge from sperm resulting PCS and neutrally charged sperm, while the charged sperm populations are increased with an increase in electrophoretic current. Following DGC, high sperm DNA damage and abnormal histone retention were inversely correlated with percentage NCS and directly correlated with percentage PCS. NCS exhibited significantly lower DNA damage when compared with control (P < 0.05) and PCS (P < 0.05). When the charged sperm population was corrected for neutrally charged sperm, sperm DNA damage was strongly associated with NCS at a lower electrophoretic current. The results suggest that selection of NCS at lower current may be an important biomarker to select healthy sperm for assisted reproductive treatment.

Thermospheric neutral density estimates from heater-induced ion up-flow at EISCAT

NASA Astrophysics Data System (ADS)

Kosch, Michael; Ogawa, Yasunobu; Yamazaki, Yosuke; Vickers, Hannah; Blagoveshchenskaya, Nataly

We exploit a recently-developed technique to estimate the upper thermospheric neutral density using measurements of ionospheric plasma parameters made by the EISCAT UHF radar during ionospheric modification experiments. Heating the electrons changes the balance between upward plasma pressure gradient and downward gravity, resulting in ion up-flow up to ~200 m/s. This field-aligned flow is retarded by collisions, which is directly related to the neutral density. Whilst the ion up-flow is consistent with the plasma pressure gradient, the estimated thermospheric neutral density depends on the assumed composition, which varies with altitude. Results in the topside ionosphere are presented.

Magnetic configurations of the tilted current sheets in magnetotail

NASA Astrophysics Data System (ADS)

Shen, C.; Rong, Z. J.; Li, X.; Dunlop, M.; Liu, Z. X.; Malova, H. V.; Lucek, E.; Carr, C.

2008-11-01

In this research, the geometrical structures of tilted current sheet and tail flapping waves have been analysed based on multiple spacecraft measurements and some features of the tilted current sheets have been made clear for the first time. The geometrical features of the tilted current sheet revealed in this investigation are as follows: (1) The magnetic field lines (MFLs) in the tilted current sheet are generally plane curves and the osculating planes in which the MFLs lie are about vertical to the equatorial plane, while the normal of the tilted current sheet leans severely to the dawn or dusk side. (2) The tilted current sheet may become very thin, the half thickness of its neutral sheet is generally much less than the minimum radius of the curvature of the MFLs. (3) In the neutral sheet, the field-aligned current density becomes very large and has a maximum value at the center of the current sheet. (4) In some cases, the current density is a bifurcated one, and the two humps of the current density often superpose two peaks in the gradient of magnetic strength, indicating that the magnetic gradient drift current is possibly responsible for the formation of the two humps of the current density in some tilted current sheets. Tilted current sheets often appear along with tail current sheet flapping waves. It is found that, in the tail flapping current sheets, the minimum curvature radius of the MFLs in the current sheet is rather large with values around 1 RE, while the neutral sheet may be very thin, with its half thickness being several tenths of RE. During the flapping waves, the current sheet is tilted substantially, and the maximum tilt angle is generally larger than 45°. The phase velocities of these flapping waves are several tens km/s, while their periods and wavelengths are several tens of minutes, and several earth radii, respectively. These tail flapping events generally last several hours and occur during quiet periods or periods of weak magnetospheric activity.

Cp Asymmetries in B0DECAYS Beyond the Standard Model

NASA Astrophysics Data System (ADS)

Dib, Claudio O.; London, David; Nir, Yosef

Of the many ingredients of the Standard Model that are relevant to the analysis of CP asymmetries in B0 decays, some are likely to hold even beyond the Standard Model while others are sensitive to new physics. Consequently, certain predictions are maintained while others may show dramatic deviations from the Standard Model. Many classes of models may show clear signatures when the asymmetries are measured: four quark generations, Z-mediated flavor-changing neutral currents, supersymmetry and “real superweak” models. On the other hand, models of left-right symmetry and multi-Higgs sectors with natural flavor conservation are unlikely to modify the Standard Model predictions.

Searching for New Physics via CP Violation in B → ππ

NASA Astrophysics Data System (ADS)

London, David; Sinha, Nita; Sinha, Rahul

We show how B → ππ decays can be used to search for new physics in the b → d flavour-changing neutral current. One needs one piece of theoretical input, which we take to be a prediction for P/T, the ratio of the penguin and tree amplitudes in B_d^0 to {π ^ + }{π ^ - }. If present, new physics can be detected over most of the parameter space. If α (ɸ2) can be obtained independently, measurements of B+ → π+π0 and B_d^0/overline {B_d^0} to {π ^0}{π ^0} are not even needed.

Rare Higgs three body decay induced by top-Higgs FCNC coupling in the littlest Higgs model with T-parity

NASA Astrophysics Data System (ADS)

Yang, Bing-Fang; Liu, Zhi-Yong; Liu, Ning

2017-04-01

Motivated by the search for flavor-changing neutral current (FCNC) top quark decays at the LHC, we calculate the rare Higgs three body decay H → Wbc induced by top-Higgs FCNC coupling in the littlest Higgs model with T-parity (LHT). We find that the branching ratio of H → Wbc in the LHT model can reach O(10-7) in the allowed parameter space. Supported by National Natural Science Foundation of China (11305049, 11405047), Startup Foundation for Doctors of Henan Normal University (11112, qd15207) and Education Department Foundation of Henan Province(14A140010)

Experimental Simulation of the Interaction of Biased Solar Arrays with the Space Plasma

NASA Technical Reports Server (NTRS)

Kaufman, H. R.; Robinson, R. S.

1981-01-01

The phenomenon of unexpectedly large leakage currents collected by small exposed areas of high voltage solar arrays operating in a plasma environment was investigated. Polyimide (Kapton) was the insulating material used in all tests. Both positive bias (electron collection) and negative bias (ion collection) tests were performed. A mode change in the electron collection mechanism was associated with a glow discharge process and was found to be related to the neutral background density. Results indicate that the glow discharge collection mode does not occur in a space environment where the background density is considerably lower than that of the vacuum facility used.

Modelling climate change, land-use change and phosphorus reduction impacts on phytoplankton in the River Thames (UK)

NASA Astrophysics Data System (ADS)

Bussi, Gianbattista; Whitehead, Paul; Dadson, Simon

2016-04-01

In this study, we assess the impact of changes in precipitation and temperature on the phytoplankton concentration of the River Thames (UK) by means of a physically-based model. A scenario-neutral approach was employed to evaluate the effects of climate variability on flow, phosphorus concentration and phytoplankton concentration. In particular, the impact of uniform changes in precipitation and temperature on five groups of phytoplankton (diatoms and large chlorophytes, other chlorophytes, picoalgae, Microcystis-like cyanobacteria and other cyanobacteria) was assessed under three different land-use/land-management scenarios (1 - current land use and phosphorus reduction practices; 2 - expansion of agricultural land and current phosphorus reduction practices; 3 - expansion of agricultural land and optimal phosphorus reduction practices). The model results were assessed within the framework of future climate projections, using the UK Climate Projections 09 (UKCP09) for the 2030s. The results of the model demonstrate that an increase in average phytoplankton concentration due to climate change is highly likely to occur, and its magnitude varies depending on the river reach. Cyanobacteria show significant increases under future climate change and land-use change. An expansion of intensive agriculture accentuates the growth in phytoplankton, especially in the upper reaches of the River Thames. However, an optimal phosphorus removal mitigation strategy, which combines reduction of fertiliser application and phosphorus removal from wastewater, can help to reduce this increase in phytoplankton concentration, and in some cases, compensate for the effect of rising temperature.

Neutralization, by a monospecific Bothrops lanceolatus antivenom, of toxic activities induced by homologous and heterologous Bothírops snake venoms.

PubMed

Bogarín, G; Romero, M; Rojas, G; Lutsch, C; Casadamont, M; Lang, J; Otero, R; Gutiérrez, J M

1999-03-01

A monospecific Bothrops lanceolatus antivenom, currently used in Martinique, was tested for its efficacy in the neutralization of several toxic and enzymatic activities of the venoms of B. lanceolatus, B. atrox and B. asper. When tested by the i.p. route in mice, B. lanceolatus venom had an LD50 of 12.8 microg/g. In addition, it induced local tissue damage (hemorrhage, edema and myotoxicity) and showed indirect hemolytic activity, but was devoid of coagulant effect on human plasma in vitro and of defibrinating activity in mice. Antivenom was fully effective in the neutralization of lethal, hemorrhagic, edema-forming, myotoxic and indirect hemolytic effects of B. lanceolatus venom in assays involving preincubation of venom and antivenom. When tested against the venoms of B. asper and B. atrox, the antivenom completely neutralized the lethal, hemorrhagic, myotoxic and indirect hemolytic effects, and was partially effective in neutralizing edema-forming activity. In contrast, the antivenom was ineffective in the neutralization of in vitro coagulant and in vivo defibrinating effects induced by these two venoms.

A novel reporter system for neutralizing and enhancing antibody assay against dengue virus.

PubMed

Song, Ke-Yu; Zhao, Hui; Jiang, Zhen-You; Li, Xiao-Feng; Deng, Yong-Qiang; Jiang, Tao; Zhu, Shun-Ya; Shi, Pei-Yong; Zhang, Bo; Zhang, Fu-Chun; Qin, E-De; Qin, Cheng-Feng

2014-02-18

Dengue virus (DENV) still poses a global public health threat, and no vaccine or antiviral therapy is currently available. Antibody plays distinct roles in controlling DENV infections. Neutralizing antibody is protective against DENV infection, whereas sub-neutralizing concentration of antibody can increase DENV infection, termed antibody-dependent enhancement (ADE). Plaque-based assay represents the most widely accepted method measuring neutralizing or enhancing antibodies. In this study, a novel reporter virus-based system was developed for measuring neutralization and ADE activity. A stable Renilla luciferase reporter DENV (Luc-DENV) that can produce robust luciferase signals in BHK-21 and K562 cells were used to establish the assay and validated against traditional plaque-based assay. Luciferase value analysis using various known DENV-specific monoclonal antibodies showed good repeatability and a well linear correlation with conventional plaque-based assays. The newly developed assay was finally validated with clinical samples from infected animals and individuals. This reporter virus-based assay for neutralizing and enhancing antibody evaluation is rapid, lower cost, and high throughput, and will be helpful for laboratory detection and epidemiological investigation for DENV antibodies.

The Hepatitis C Virus Glycan Shield and Evasion of the Humoral Immune Response

PubMed Central

Helle, François; Duverlie, Gilles; Dubuisson, Jean

2011-01-01

Despite the induction of effective immune responses, 80% of hepatitis C virus (HCV)-infected individuals progress from acute to chronic hepatitis. In contrast to the cellular immune response, the role of the humoral immune response in HCV clearance is still subject to debate. Indeed, HCV escapes neutralizing antibodies in chronically infected patients and reinfection has been described in human and chimpanzee. Studies of antibody-mediated HCV neutralization have long been hampered by the lack of cell-culture-derived virus and the absence of a small animal model. However, the development of surrogate models and recent progress in HCV propagation in vitro now enable robust neutralization assays to be performed. These advances are beginning to shed some light on the mechanisms of HCV neutralization. This review summarizes the current state of knowledge of the viral targets of anti-HCV-neutralizing antibodies and the mechanisms that enable HCV to evade the humoral immune response. The recent description of the HCV glycan shield that reduces the immunogenicity of envelope proteins and masks conserved neutralizing epitopes at their surface constitutes the major focus of this review. PMID:22069522

Scale Sizes of High-Latitude Neutral Mass Density Perturbations

NASA Astrophysics Data System (ADS)

Huang, C. Y.; Huang, Y.; Su, Y. J.; Huang, T.; Sutton, E. K.

2017-12-01

In a statistical study of neutral mass density maxima, we found for a select interval, that 57% of the maxima have correlated field-aligned current (FAC) signatures, indicative of localized Ohmic heating. However the remaining 43% do not, and we suggested that these maxima may be due to gravity waves generated by neutral heating. We follow up on this study by an investigation into the spatial scale sizes of the mass density maxima using high-resolution neutral density and FAC data from CHAMP, when the satellite is in conjunction with DMSP, which provides the corresponding ion drift velocity, particle precipitation and Poynting flux. The study shows the average scale sizes of the perturbations due to J x B heating, as well as the sizes of the waves generated by Joule heating.

The Mechanism of Functional Up-Regulation of P2X3 Receptors of Trigeminal Sensory Neurons in a Genetic Mouse Model of Familial Hemiplegic Migraine Type 1 (FHM-1)

PubMed Central

Hullugundi, Swathi K.; Ferrari, Michel D.; van den Maagdenberg, Arn M. J. M.; Nistri, Andrea

2013-01-01

A knock-in (KI) mouse model of FHM-1 expressing the R192Q missense mutation of the Cacna1a gene coding for the α1 subunit of CaV2.1 channels shows, at the level of the trigeminal ganglion, selective functional up-regulation of ATP -gated P2X3 receptors of sensory neurons that convey nociceptive signals to the brainstem. Why P2X3 receptors are constitutively more responsive, however, remains unclear as their membrane expression and TRPV1 nociceptor activity are the same as in wildtype (WT) neurons. Using primary cultures of WT or KI trigeminal ganglia, we investigated whether soluble compounds that may contribute to initiating (or maintaining) migraine attacks, such as TNFα, CGRP, and BDNF, might be responsible for increasing P2X3 receptor responses. Exogenous application of TNFα potentiated P2X3 receptor-mediated currents of WT but not of KI neurons, most of which expressed both the P2X3 receptor and the TNFα receptor TNFR2. However, sustained TNFα neutralization failed to change WT or KI P2X3 receptor currents. This suggests that endogenous TNFα does not regulate P2X3 receptor responses. Nonetheless, on cultures made from both genotypes, exogenous TNFα enhanced TRPV1 receptor-mediated currents expressed by a few neurons, suggesting transient amplification of TRPV1 nociceptor responses. CGRP increased P2X3 receptor currents only in WT cultures, although prolonged CGRP receptor antagonism or BDNF neutralization reduced KI currents to WT levels. Our data suggest that, in KI trigeminal ganglion cultures, constitutive up-regulation of P2X3 receptors probably is already maximal and is apparently contributed by basal CGRP and BDNF levels, thereby rendering these neurons more responsive to extracellular ATP. PMID:23577145

Kinetic Simulation and Energetic Neutral Atom Imaging of the Magnetosphere

NASA Technical Reports Server (NTRS)

Fok, Mei-Ching H.

2011-01-01

Advanced simulation tools and measurement techniques have been developed to study the dynamic magnetosphere and its response to drivers in the solar wind. The Comprehensive Ring Current Model (CRCM) is a kinetic code that solves the 3D distribution in space, energy and pitch-angle information of energetic ions and electrons. Energetic Neutral Atom (ENA) imagers have been carried in past and current satellite missions. Global morphology of energetic ions were revealed by the observed ENA images. We have combined simulation and ENA analysis techniques to study the development of ring current ions during magnetic storms and substorms. We identify the timing and location of particle injection and loss. We examine the evolution of ion energy and pitch-angle distribution during different phases of a storm. In this talk we will discuss the findings from our ring current studies and how our simulation and ENA analysis tools can be applied to the upcoming TRIO-CINAMA mission.

Progress of long pulse operation with high performance plasma in KSTAR

NASA Astrophysics Data System (ADS)

Bae, Young; Kstar Team

2015-11-01

Recent KSTAR experiments showed the sustained H-mode operation up to the pulse duration of 46 s at the plasma current of 600 kA. The long-pulse H-mode operation has been supported by long-pulse capable neutral beam injection (NBI) system with high NB current drive efficiency attributed by highly tangential injections of three beam sources. In next phase, aiming to demonstrate the long pulse stationary high performance plasma operation, we are attempting the long pulse inductive operation at the higher performance (MA plasma current, high normalized beta, and low q95) for the final goal of demonstration of ITER-like baseline scenario in KSTAR with progressive improvement of the plasma shape control and higher neutral beam injection power. This paper presents the progress of long pulse operation and the analysis of energy confinement time and non-inductive current drive in KSTAR.

Quantum Monte Carlo calculation of neutral-current ν - C 12 inclusive quasielastic scattering

DOE PAGES

Lovato, A.; Gandolfi, S.; Carlson, J.; ...

2018-02-28

Quasielastic neutrino scattering is an important aspect of the experimental program to study fundamental neutrino properties including neutrino masses, mixing angles, the mass hierarchy and CP-violating phase. Proper interpretation of the experiments requires reliable theoretical calculations of neutrino-nucleus scattering. In this paper we present calculations of response functions and cross sections by neutral-current scattering of neutrinos offmore » $$^{12}$$C. These calculations are based on realistic treatments of nuclear interactions and currents, the latter including the axial, vector, and vector-axial interference terms crucial for determining the difference between neutrino and anti-neutrino scattering and the CP-violating phase. Here in this paper, we find that the strength and energy-dependence of two-nucleon processes induced by correlation effects and interaction currents are crucial in providing the most accurate description of neutrino-nucleus scattering in the quasielastic regime.« less

Microscopic model of quasiparticle wave packets in superfluids, superconductors, and paired Hall states.

PubMed

Parameswaran, S A; Kivelson, S A; Shankar, R; Sondhi, S L; Spivak, B Z

2012-12-07

We study the structure of Bogoliubov quasiparticles, bogolons, the fermionic excitations of paired superfluids that arise from fermion (BCS) pairing, including neutral superfluids, superconductors, and paired quantum Hall states. The naive construction of a stationary quasiparticle in which the deformation of the pair field is neglected leads to a contradiction: it carries a net electrical current even though it does not move. However, treating the pair field self-consistently resolves this problem: in a neutral superfluid, a dipolar current pattern is associated with the quasiparticle for which the total current vanishes. When Maxwell electrodynamics is included, as appropriate to a superconductor, this pattern is confined over a penetration depth. For paired quantum Hall states of composite fermions, the Maxwell term is replaced by a Chern-Simons term, which leads to a dipolar charge distribution and consequently to a dipolar current pattern.

Quantum Monte Carlo calculation of neutral-current ν - C 12 inclusive quasielastic scattering

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lovato, A.; Gandolfi, S.; Carlson, J.

Quasielastic neutrino scattering is an important aspect of the experimental program to study fundamental neutrino properties including neutrino masses, mixing angles, the mass hierarchy and CP-violating phase. Proper interpretation of the experiments requires reliable theoretical calculations of neutrino-nucleus scattering. In this paper we present calculations of response functions and cross sections by neutral-current scattering of neutrinos offmore » $$^{12}$$C. These calculations are based on realistic treatments of nuclear interactions and currents, the latter including the axial, vector, and vector-axial interference terms crucial for determining the difference between neutrino and anti-neutrino scattering and the CP-violating phase. Here in this paper, we find that the strength and energy-dependence of two-nucleon processes induced by correlation effects and interaction currents are crucial in providing the most accurate description of neutrino-nucleus scattering in the quasielastic regime.« less

Extreme energetic particle decreases near geostationary orbit - A manifestation of current diversion within the inner plasma sheet

NASA Technical Reports Server (NTRS)

Baker, D. N.; Mcpherron, R. L.

1990-01-01

A qualitative model of magnetic field reconfiguration as might result from neutral line formation in the central plasma sheet late in a substorm growth phase is considered. It is suggested that magnetic reconnection probably begins before the substorm expansion phase and that cross-tail current is enhanced across the plasma sheet both earthward and tailward of a limited region near the neutral line. Such an enhanced cross-tail current earthward of the original X line region may contribute to thinning the plasma sheet substantially, and this would in turn affect the drift currents in that location, thus enhancing the current even closer toward the earth. In this way a redistribution and progressive diversion of normal cross-tail current throughout much of the inner portion of the plasma sheet could occur. The resulting intensified current, localized at the inner edge of the plasma sheet, would lead to a very thin plasma confinement region. This would explain the very taillike field and extreme particle dropouts often seen late in substorm growth phases.

Development of a new polyspecific antivenom for snakebite envenoming in Sri Lanka: Analysis of its preclinical efficacy as compared to a currently available antivenom.

PubMed

Villalta, Mauren; Sánchez, Andrés; Herrera, María; Vargas, Mariángela; Segura, Álvaro; Cerdas, Maykel; Estrada, Ricardo; Gawarammana, Indika; Keyler, Dan E; McWhorter, Kimberly; Malleappah, Roy; Alape-Girón, Alberto; León, Guillermo; Gutiérrez, José María

2016-11-01

A new whole IgG, freeze-dried, polyspecific antivenom was prepared from the plasma of horses immunized with the venoms of the snakes Daboia russelii, Echis carinatus, Hypnale hypnale, and Naja naja from Sri Lanka. The preclinical neutralizing ability of this antivenom against several toxic and enzymatic activities of these four venoms was analyzed, and compared with that of a batch of VINS antivenom (India) being currently used in Sri Lanka. The activities tested were: lethality, hemorrhagic, in vitro coagulant, proteinase and phospholipase A 2 . Both antivenoms neutralized, to a different extent, these activities of the venom of D. russelii, E. carinatus, and N. naja. In general, the polyspecific Sri Lankan antivenom was more effective than the Indian antivenom in the neutralization of the venoms of D. russelii and E. carinatus, whereas the Indian antivenom showed a higher efficacy against the venom of N. naja. Regarding H. hypnale, the new Sri Lankan antivenom was effective in the neutralization of all activities tested, whereas the Indian antivenom neutralized lethality but not hemorrhagic, coagulant, proteinase and PLA 2 activities, in agreement with the fact that this venom is not included in the immunization mixture for this antivenom. Results suggest that the new polyspecific Sri Lankan antivenom has a satisfactory preclinical neutralizing profile and compares favorably with the Indian antivenom. This is ready to be tested in a clinical trial to evaluate its efficacy and safety in human victims of snakebite envenomings by D. russelii, E. carinatus and H. hypnale in Sri Lanka. Copyright © 2016 Elsevier Ltd. All rights reserved.

Genomic signatures of rapid adaptive evolution in the bluespotted cornetfish, a Mediterranean Lessepsian invader.

PubMed

Bernardi, Giacomo; Azzurro, Ernesto; Golani, Daniel; Miller, Michael Ryan

2016-07-01

Biological invasions are increasingly creating ecological and economical problems both on land and in aquatic environments. For over a century, the Mediterranean Sea has steadily been invaded by Indian Ocean/Red Sea species (called Lessepsian invaders) via the Suez Canal, with a current estimate of ~450 species. The bluespotted cornetfish, Fistularia commersonii, considered a 'Lessepsian sprinter', entered the Mediterranean in 2000 and by 2007 had spread through the entire basin from Israel to Spain. The situation is unique and interesting both because of its unprecedented rapidity and by the fact that it took this species c. 130 years to immigrate into the Mediterranean. Using genome scans, with restriction site-associated DNA (RAD) sequencing, we evaluated neutral and selected genomic regions for Mediterranean vs. Red Sea cornetfish individuals. We found that few fixed neutral changes were detectable among populations. However, almost half of the genes associated with the 47 outlier loci (potentially under selection) were related to disease resistance and osmoregulation. Due to the short time elapsed from the beginning of the invasion to our sampling, we interpret these changes as signatures of rapid adaptation that may be explained by several mechanisms including preadaptation and strong local selection. Such genomic regions are therefore good candidates to further study their role in invasion success. © 2016 John Wiley & Sons Ltd.

Threats, rewards, and attention deployment in anxious youth and adults: An eye tracking study.

PubMed

Shechner, Tomer; Jarcho, Johanna M; Wong, Stuart; Leibenluft, Ellen; Pine, Daniel S; Nelson, Eric E

2017-01-01

The current study examines anxiety and age associations with attention allocation and physiological response to threats and rewards. Twenty-two healthy-adults, 20 anxious-adults, 26 healthy-youth, and 19 anxious-youth completed two eye-tracking tasks. In the Visual Scene Task (VST), participants' fixations were recorded while they viewed a central neutral image flanked by two threatening or two rewarding stimuli. In the Negative Words Task (NWT), physiological response was measured by means of pupil diameter change while negative and neutral words were presented. For both tasks, no interaction was found between anxiety and age-group. In the VST, anxious participants avoided the threatening images when groups were collapsed across age. Similarly, adults but not adolescents avoided the threatening images when collapsed across anxiety. No differences were found for rewarding images. In NWT, all subjects demonstrated increase in pupil dilation after word presentation. Only main effect of age emerged with stronger pupil dilation in adults than children. Finally, maximum pupil change was correlated with threat avoidance bias in the scene task. Gaze patterns and pupil dilation show that anxiety and age are associated with attention allocation to threats. The relations between attention and autonomic arousal point to a complex interaction between bottom-up and top-down processes as they relate to attention allocation. Copyright © 2015 Elsevier B.V. All rights reserved.

Cost-effectiveness of volumetric alcohol taxation in Australia.

PubMed

Byrnes, Joshua M; Cobiac, Linda J; Doran, Christopher M; Vos, Theo; Shakeshaft, Anthony P

2010-04-19

To estimate the potential health benefits and cost savings of an alcohol tax rate that applies equally to all alcoholic beverages based on their alcohol content (volumetric tax) and to compare the cost savings with the cost of implementation. Mathematical modelling of three scenarios of volumetric alcohol taxation for the population of Australia: (i) no change in deadweight loss, (ii) no change in tax revenue, and (iii) all alcoholic beverages taxed at the same rate as spirits. Estimated change in alcohol consumption, tax revenue and health benefit. The estimated cost of changing to a volumetric tax rate is $18 million. A volumetric tax that is deadweight loss-neutral would increase the cost of beer and wine and reduce the cost of spirits, resulting in an estimated annual increase in taxation revenue of $492 million and a 2.77% reduction in annual consumption of pure alcohol. The estimated net health gain would be 21 000 disability-adjusted life-years (DALYs), with potential cost offsets of $110 million per annum. A tax revenue-neutral scenario would result in an 0.05% decrease in consumption, and a tax on all alcohol at a spirits rate would reduce consumption by 23.85% and increase revenue by $3094 million [corrected]. All volumetric tax scenarios would provide greater health benefits and cost savings to the health sector than the existing taxation system, based on current understandings of alcohol-related health effects. An equalized volumetric tax that would reduce beer and wine consumption while increasing the consumption of spirits would need to be approached with caution. Further research is required to examine whether alcohol-related health effects vary by type of alcoholic beverage independent of the amount of alcohol consumed to provide a strong evidence platform for alcohol taxation policies.

MHD and resonant instabilities in JT-60SA during current ramp-up with off-axis N-NB injection

NASA Astrophysics Data System (ADS)

Bierwage, A.; Toma, M.; Shinohara, K.

2017-12-01

The excitation of magnetohydrodynamic (MHD) and resonant instabilities and their effect on the plasma profiles during the current ramp-up phase of a beam-driven JT-60SA tokamak plasma is studied using the MHD-PIC hybrid code MEGA. In the simple scenario considered, the plasma is only driven by one negative-ion-based neutral beam, depositing 500 keV deuterons at 5 MW power off-axis at about mid-radius. The beam injection starts half-way in the ramp-up phase. Within 1 s, the beam-driven plasma current and fast ion pressure produce a configuration that is strongly unstable to rapidly growing MHD and resonant modes. Using MEGA, modes with low toroidal mode numbers in the range n = 1-4 are examined in detail and shown to cause substantial changes in the plasma profiles. The necessity to develop reduced models and incorporate the effects of such instabilities in integrated codes used to simulate the evolution of entire plasma discharges is discussed.

Mathematics: A Female, Male or Gender-Neutral Domain? A Study of Attitudes among Students at Secondary Level

ERIC Educational Resources Information Center

Brandell, Gerd; Staberg, Else-Marie

2008-01-01

The aim of the current study is to investigate whether Swedish secondary school students perceive mathematics as a female, male or gender-neutral domain. A sample of 1300 students in two age groups, 15- and 17- years, answered a questionnaire and about 50 students participated in interviews. The main part of the inquiry form consists of "Who…

Total Marketing: A Study of Image

DTIC Science & Technology

1990-08-01

marketing , and advertising are all successful in creating an initial awareness of the military. Potential recruits see recruiters at their schools, they...Direct mail marketing is impressive at first but soon wears out. It does not seem to provide new information. " Advertising , to the extent that it...awareness, current recruiting efforts net out as: Recruiter Contact - Negative Advertising - Neutral Direct Marketing - Neutral * 2. Recruitment Stage

Spectroscopic determination of the composition of a 50 kV hydrogen diagnostic neutral beam

DOE Office of Scientific and Technical Information (OSTI.GOV)

Feng, X.; Nornberg, M. D., E-mail: mdnornberg@wisc.edu; Den Hartog, D. J.

2016-11-15

A grating spectrometer with an electron multiplying charge-coupled device camera is used to diagnose a 50 kV, 5 A, 20 ms hydrogen diagnostic neutral beam. The ion source density is determined from Stark broadened H{sub β} emission and the spectrum of Doppler-shifted H{sub α} emission is used to quantify the fraction of ions at full, half, and one-third beam energy under a variety of operating conditions including fueling gas pressure and arc discharge current. Beam current is optimized at low-density conditions in the ion source while the energy fractions are found to be steady over most operating conditions.

Radiated and conducted EMI from a 30-cm ion thruster

NASA Technical Reports Server (NTRS)

Whittlesey, A. C.; Peer, W.

1981-01-01

In order to properly assess the interaction of a spacecraft with the EMI environment produced by an ion thruster, the EMI environment was characterized. Therefore, radiated and conducted emissions were measured from a 30-cm mercury ion thruster. The ion thruster beam current varied from zero to 2.0 amperes and the emissions were measured from 5 KHz to 200 MHz. Several different types of antennas were used to obtain the measurements. The various measurements that were made included: magnetic field due to neutralizer/beam current loop; radiated electric fields of thruster and plume; and conducted emissions on arc discharge, neutralizer keeper and magnetic baffle lines.

In-line beam current monitor

DOEpatents

Ekdahl, Jr., Carl A.; Frost, Charles A.

1986-01-01

An intense relativistic electron beam current monitor for a gas neutralized beam transport line includes a first foil for conducting plasma current to the wall where it is measured as it traverses an inductive loop formed by a cavity in the wall. An insulator foil separates the first foil from a second conducting foil which returns the current to the plasma environment.

In-line beam current monitor

DOEpatents

Ekdahl, C.A. Jr.; Frost, C.A.

1984-11-13

An intense relativistic electron beam current monitor for a gas neutralized beam transport line includes a first foil for conducting plasma current to the wall where it is measured as it traverses an inductive loop formed by a cavity in the wall. An insulator foil separates the first foil from a second conducting foil which returns the current to the plasma environment.

Measurement of single π 0 production by coherent neutral-current ν Fe interactions in the MINOS Near Detector

DOE Office of Scientific and Technical Information (OSTI.GOV)

Adamson, P.; Anghel, I.; Aurisano, A.

Forward single π0 production by coherent neutral-current interactions, νA→νAπ 0, is investigated using a 2.8×10 20 protons-on-target exposure of the MINOS Near Detector. For single-shower topologies, the event distribution in production angle exhibits a clear excess above the estimated background at very forward angles for visible energy in the range 1–8 GeV. Cross sections are obtained for the detector medium comprised of 80% iron and 20% carbon nuclei withmore » $$\\langle$$A$$\\rangle$$=48, the highest-$$\\langle$$A$$\\rangle$$ target used to date in the study of this coherent reaction. In conclusion, the total cross section for coherent neutral-current single π 0 production initiated by the ν μ flux of the NuMI low-energy beam with mean (mode) E ν of 4.9 GeV (3.0 GeV), is 77.6±5.0(stat)$$+15.0\\atop{-16.8}$$(syst)×10 -40 cm 2 pernucleus. Finally, the results are in good agreement with predictions of the Berger-Sehgal model.« less

Measurement of the single π0 production rate in neutral current neutrino interactions on water

NASA Astrophysics Data System (ADS)

Abe, K.; Amey, J.; Andreopoulos, C.; Antonova, M.; Aoki, S.; Ariga, A.; Ashida, Y.; Assylbekov, S.; Autiero, D.; Ban, S.; Barbi, M.; Barker, G. J.; Barr, G.; Barry, C.; Bartet-Friburg, P.; Batkiewicz, M.; Berardi, V.; Berkman, S.; Bhadra, S.; Bienstock, S.; Blondel, A.; Bolognesi, S.; Bordoni, S.; Boyd, S. B.; Brailsford, D.; Bravar, A.; Bronner, C.; Buizza Avanzini, M.; Calland, R. G.; Campbell, T.; Cao, S.; Cartwright, S. L.; Castillo, R.; Catanesi, M. G.; Cervera, A.; Chappell, A.; Checchia, C.; Cherdack, D.; Chikuma, N.; Christodoulou, G.; Clifton, A.; Coleman, J.; Collazuol, G.; Coplowe, D.; Cremonesi, L.; Cudd, A.; Dabrowska, A.; De Rosa, G.; Dealtry, T.; Denner, P. F.; Dennis, S. R.; Densham, C.; Dewhurst, D.; Di Lodovico, F.; Di Luise, S.; Dolan, S.; Drapier, O.; Duffy, K. E.; Dumarchez, J.; Dunkman, M.; Dunne, P.; Dziewiecki, M.; Emery-Schrenk, S.; Ereditato, A.; Feusels, T.; Finch, A. J.; Fiorentini, G. A.; Friend, M.; Fujii, Y.; Fukuda, D.; Fukuda, Y.; Furmanski, A. P.; Galymov, V.; Garcia, A.; Giffin, S. G.; Giganti, C.; Gilje, K.; Gizzarelli, F.; Golan, T.; Gonin, M.; Grant, N.; Hadley, D. R.; Haegel, L.; Haigh, J. T.; Hamilton, P.; Hansen, D.; Harada, J.; Hara, T.; Hartz, M.; Hasegawa, T.; Hastings, N. C.; Hayashino, T.; Hayato, Y.; Helmer, R. L.; Hierholzer, M.; Hillairet, A.; Himmel, A.; Hiraki, T.; Hiramoto, A.; Hirota, S.; Hogan, M.; Holeczek, J.; Hosomi, F.; Huang, K.; Ichikawa, A. K.; Ieki, K.; Ikeda, M.; Imber, J.; Insler, J.; Intonti, R. A.; Irvine, T. J.; Ishida, T.; Ishii, T.; Iwai, E.; Iwamoto, K.; Izmaylov, A.; Jacob, A.; Jamieson, B.; Jiang, M.; Johnson, S.; Jo, J. H.; Jonsson, P.; Jung, C. K.; Kabirnezhad, M.; Kaboth, A. C.; Kajita, T.; Kakuno, H.; Kameda, J.; Karlen, D.; Karpikov, I.; Katori, T.; Kearns, E.; Khabibullin, M.; Khotjantsev, A.; Kielczewska, D.; Kikawa, T.; Kim, H.; Kim, J.; King, S.; Kisiel, J.; Knight, A.; Knox, A.; Kobayashi, T.; Koch, L.; Koga, T.; Koller, P. P.; Konaka, A.; Kondo, K.; Kopylov, A.; Kormos, L. L.; Korzenev, A.; Koshio, Y.; Kowalik, K.; Kropp, W.; Kudenko, Y.; Kurjata, R.; Kutter, T.; Lagoda, J.; Lamont, I.; Lamoureux, M.; Larkin, E.; Lasorak, P.; Laveder, M.; Lawe, M.; Lazos, M.; Licciardi, M.; Lindner, T.; Liptak, Z. J.; Litchfield, R. P.; Li, X.; Longhin, A.; Lopez, J. P.; Lou, T.; Ludovici, L.; Lu, X.; Magaletti, L.; Mahn, K.; Malek, M.; Manly, S.; Maret, L.; Marino, A. D.; Marteau, J.; Martin, J. F.; Martins, P.; Martynenko, S.; Maruyama, T.; Matveev, V.; Mavrokoridis, K.; Ma, W. Y.; Mazzucato, E.; McCarthy, M.; McCauley, N.; McFarland, K. S.; McGrew, C.; Mefodiev, A.; Metelko, C.; Mezzetto, M.; Mijakowski, P.; Minamino, A.; Mineev, O.; Mine, S.; Missert, A.; Miura, M.; Moriyama, S.; Morrison, J.; Mueller, Th. A.; Murphy, S.; Myslik, J.; Nakadaira, T.; Nakahata, M.; Nakamura, K. G.; Nakamura, K.; Nakamura, K. D.; Nakanishi, Y.; Nakayama, S.; Nakaya, T.; Nakayoshi, K.; Nantais, C.; Nielsen, C.; Nirkko, M.; Nishikawa, K.; Nishimura, Y.; Novella, P.; Nowak, J.; O'Keeffe, H. M.; Ohta, R.; Okumura, K.; Okusawa, T.; Oryszczak, W.; Oser, S. M.; Ovsyannikova, T.; Owen, R. A.; Oyama, Y.; Palladino, V.; Palomino, J. L.; Paolone, V.; Patel, N. D.; Paudyal, P.; Pavin, M.; Payne, D.; Perkin, J. D.; Petrov, Y.; Pickard, L.; Pickering, L.; Pinzon Guerra, E. S.; Pistillo, C.; Popov, B.; Posiadala-Zezula, M.; Poutissou, J.-M.; Poutissou, R.; Pritchard, A.; Przewlocki, P.; Quilain, B.; Radermacher, T.; Radicioni, E.; Ratoff, P. N.; Ravonel, M.; Rayner, M. A.; Redij, A.; Reinherz-Aronis, E.; Riccio, C.; Rojas, P.; Rondio, E.; Rossi, B.; Roth, S.; Rubbia, A.; Ruggeri, A. C.; Rychter, A.; Sacco, R.; Sakashita, K.; Sánchez, F.; Sato, F.; Scantamburlo, E.; Scholberg, K.; Schwehr, J.; Scott, M.; Seiya, Y.; Sekiguchi, T.; Sekiya, H.; Sgalaberna, D.; Shah, R.; Shaikhiev, A.; Shaker, F.; Shaw, D.; Shiozawa, M.; Shirahige, T.; Short, S.; Smy, M.; Sobczyk, J. T.; Sobel, H.; Sorel, M.; Southwell, L.; Stamoulis, P.; Steinmann, J.; Stewart, T.; Stowell, P.; Suda, Y.; Suvorov, S.; Suzuki, A.; Suzuki, K.; Suzuki, S. Y.; Suzuki, Y.; Tacik, R.; Tada, M.; Takahashi, S.; Takeda, A.; Takeuchi, Y.; Tamura, R.; Tanaka, H. K.; Tanaka, H. A.; Terhorst, D.; Terri, R.; Thakore, T.; Thompson, L. F.; Tobayama, S.; Toki, W.; Tomura, T.; Touramanis, C.; Tsukamoto, T.; Tzanov, M.; Uchida, Y.; Vacheret, A.; Vagins, M.; Vallari, Z.; Vasseur, G.; Vilela, C.; Vladisavljevic, T.; Wachala, T.; Wakamatsu, K.; Walter, C. W.; Wark, D.; Warzycha, W.; Wascko, M. O.; Weber, A.; Wendell, R.; Wilkes, R. J.; Wilking, M. J.; Wilkinson, C.; Wilson, J. R.; Wilson, R. J.; Wret, C.; Yamada, Y.; Yamamoto, K.; Yamamoto, M.; Yanagisawa, C.; Yano, T.; Yen, S.; Yershov, N.; Yokoyama, M.; Yoo, J.; Yoshida, K.; Yuan, T.; Yu, M.; Zalewska, A.; Zalipska, J.; Zambelli, L.; Zaremba, K.; Ziembicki, M.; Zimmerman, E. D.; Zito, M.; Żmuda, J.; T2K Collaboration

2018-02-01

The single π0 production rate in neutral current neutrino interactions on water in a neutrino beam with a peak neutrino energy of 0.6 GeV has been measured using the PØD, one of the subdetectors of the T2K near detector. The production rate was measured for data taking periods when the PØD contained water (2.64 ×1020 protons-on-target) and also periods without water (3.49 ×1020 protons-on-target). A measurement of the neutral current single π0 production rate on water is made using appropriate subtraction of the production rate with water in from the rate with water out of the target region. The subtraction analysis yields 106 ±41 ±69 signal events where the uncertainties are statistical (stat.) and systematic (sys.) respectively. This is consistent with the prediction of 157 events from the nominal simulation. The measured to expected ratio is 0.68 ±0.26 (stat ) ±0.44 (sys ) ±0.12 (flux ) . The nominal simulation uses a flux integrated cross section of 7.63 ×10-39 cm2 per nucleon with an average neutrino interaction energy of 1.3 GeV.

Measurement of single π 0 production by coherent neutral-current ν Fe interactions in the MINOS Near Detector

DOE PAGES

Adamson, P.; Anghel, I.; Aurisano, A.; ...

2016-10-26

Forward single π0 production by coherent neutral-current interactions, νA→νAπ 0, is investigated using a 2.8×10 20 protons-on-target exposure of the MINOS Near Detector. For single-shower topologies, the event distribution in production angle exhibits a clear excess above the estimated background at very forward angles for visible energy in the range 1–8 GeV. Cross sections are obtained for the detector medium comprised of 80% iron and 20% carbon nuclei withmore » $$\\langle$$A$$\\rangle$$=48, the highest-$$\\langle$$A$$\\rangle$$ target used to date in the study of this coherent reaction. In conclusion, the total cross section for coherent neutral-current single π 0 production initiated by the ν μ flux of the NuMI low-energy beam with mean (mode) E ν of 4.9 GeV (3.0 GeV), is 77.6±5.0(stat)$$+15.0\\atop{-16.8}$$(syst)×10 -40 cm 2 pernucleus. Finally, the results are in good agreement with predictions of the Berger-Sehgal model.« less

A current disruption mechanism in the neutral sheet for triggering substorm expansions

NASA Technical Reports Server (NTRS)

Lui, A. T. Y.; Mankofsky, A.; Chang, C.-L.; Papadopoulos, K.; Wu, C. S.

1989-01-01

Two main areas were addressed in support of an effort to understand mechanism responsible for the broadband electrostatic noise (BEN) observed in the magnetotail. The first area concerns the generation of BEN in the boundary layer region of the magnetotail whereas the second area concerns the occassional presence of BEN in the neutral sheet region. For the generation of BEN in the boundary layer region, a hybrid simulation code was developed to perform reliable longtime, quiet, highly resolved simulations of field aligned electron and ion beam flow. The result of the simulation shows that broadband emissions cannot be generated by beam-plasma instability if realistic values of the ion beam parameters are used. The waves generated from beam-plasma instability are highly discrete and are of high frequencies. For the plasma sheet boundary layer condition, the wave frequencies are in the kHz range, which is incompatible with the observation that the peak power in BEN occur in the 10's of Hz range. It was found that the BEN characteristics are more consistent with lower hybrid drift instability. For the occasional presence of BEN in the neutral sheet region, a linear analysis of the kinetic cross-field streaming instability appropriate to the neutral sheet condition just prior to onset of substorm expansion was performed. By solving numerically the dispersion relation, it was found that the instability has a growth time comparable to the onset time scale of substorm onset. The excited waves have a mixed polarization in the lower hybrid frequency range. The imposed drift driving the instability corresponds to unmagnetized ions undergoing current sheet acceleration in the presence of a cross-tail electric field. The required electric field strength is in the 10 mV/m range which is well within the observed electric field values detected in the neutral sheet during substorms. This finding can potentially account for the disruption of cross-tail current and its diversion to the ionosphere to form the substorm current wedge. Furthermore, a number of features associated with substorm expansion onset can be understood based on this substorm onset scenario.

Experimental Measurements of the Lower Hybrid Electric Field and Induced Neutral Flow in Tore Supra by Optical Emission Spectroscopy

NASA Astrophysics Data System (ADS)

Martin, E. H.; Klepper, C. C.; Isler, R. C.; Goniche, M.; Caughman, J. B. O.

2014-10-01

Recently, the RF electric field vector (ELH) in front of a lower hybrid (LH) launcher, operating at 3.7 GHz, at the low field side of the Tore Supra tokamak was determined by spectroscopic analysis of passive Dβ spectral emission from the near-antenna plasma. The ELH was determined by globally minimizing the χ associated with the experimental and theoretical spectral line profile. The theoretical profile is calculated from a non-perturbative solution to the Schrödinger equation, which includes the magnetic and dynamic electric field vectors. The magnitude, the direction, and the scaling with LH power of the measured ELH were fairly consistent with those calculated from a full-wave LH model. In addition to ELH the inboard and an outboard neutral flow was determined from the Doppler shifts associated with the Dα and Dβ spectral profiles. It was found that excitation of the LH wave induced both an inboard and outboard co-current neutral flow, which is linearly dependent on injected power; preliminary results indicate ICRH decreases the LH wave-induced co-current neutral flow. Neutral flow velocities are consistent with measurements of ion flow velocities obtained by charge exchange recombination spectroscopy. Work supported by the US DOE under Contract No. DE-AC05-00OR22725 with UT-Battelle, LLC., and by the European Communities under the contract of Assoc. EURATOM-CEA and within the framework of the EFDA.

The effects on the ionosphere of inertia in the high latitude neutral thermosphere

NASA Technical Reports Server (NTRS)

Burns, Alan; Killeen, Timothy

1993-01-01

High-latitude ionospheric currents, plasma temperatures, densities, and composition are all affected by the time-dependent response of the neutral thermosphere to ion drag and Joule heating through a variety of complex feedback processes. These processes can best be studied numerically using the appropriate nonlinear numerical modeling techniques in conjunction with experimental case studies. In particular, the basic physics of these processes can be understood using a model, and these concepts can then be applied to more complex realistic situations by developing the appropriate simulations of real events. Finally, these model results can be compared with satellite-derived data from the thermosphere. We used numerical simulations from the National Center of Atmospheric Research Thermosphere/Ionosphere General Circulation Model (NCAR TIGCM) and data from the Dynamic Explorer 2 (DE 2) satellite to study the time-dependent effects of the inertia of the neutral thermosphere on ionospheric currents, plasma temperatures, densities, and composition. One particular case of these inertial effects is the so-called 'fly-wheel effect'. This effect occurs when the neutral gas, that has been spun-up by the large ionospheric winds associated with a geomagnetic storm, moves faster than the ions in the period after the end of the main phase of the storm. In these circumstances, the neutral gas can drag the ions along with them. It is this last effect, which is described in the next section, that we have studied under this grant.

Neutral models as a way to evaluate the Sea Level Affecting Marshes Model (SLAMM)

EPA Science Inventory

A commonly used landscape model to simulate wetland change – the Sea Level Affecting Marshes Model(SLAMM) – has rarely been explicitly assessed for its prediction accuracy. Here, we evaluated this model using recently proposed neutral models – including the random constraint matc...

Empathy, but not mimicry restriction, influences the recognition of change in emotional facial expressions.

PubMed

Kosonogov, Vladimir; Titova, Alisa; Vorobyeva, Elena

2015-01-01

The current study addressed the hypothesis that empathy and the restriction of facial muscles of observers can influence recognition of emotional facial expressions. A sample of 74 participants recognized the subjective onset of emotional facial expressions (anger, disgust, fear, happiness, sadness, surprise, and neutral) in a series of morphed face photographs showing a gradual change (frame by frame) from one expression to another. The high-empathy (as measured by the Empathy Quotient) participants recognized emotional facial expressions at earlier photographs from the series than did low-empathy ones, but there was no difference in the exploration time. Restriction of facial muscles of observers (with plasters and a stick in mouth) did not influence the responses. We discuss these findings in the context of the embodied simulation theory and previous data on empathy.

High-latitude Pi2 pulsations associated with kink-like neutral sheet oscillations

NASA Astrophysics Data System (ADS)

Wang, G. Q.; Volwerk, M.; Zhang, T. L.; Schmid, D.; Yoshikawa, A.

2017-03-01

A kink-like neutral sheet oscillation event observed by Cluster between 1436 and 1445 UT on 15 October 2004 has been investigated. The oscillations with periods between 40 and 60 s, observed at (-13.1, 8.7, -0.5) RE, are dominant in BX and BY. And they propagate mainly duskward with a velocity of (86, 147, 46) km/s. Their periods and velocity can be explained by the magnetic double-gradient instability. These oscillations are accompanied by strong field-aligned currents (FACs), which prefer to occur near the strongly tilted current sheet, and local maximum FAC tends to occur near the neutral sheet. The FACs show one-to-one correlated with a high-latitude Pi2 pulsation event recorded by KTN and TIK stations with a delay time of 60 and 90 s, respectively. Both the Pi2 and oscillations propagate westward with a comparative conjunctive speed. These findings suggest a strong relation between the FACs and Pi2, and we infer that the Pi2 is caused by the FACs. The periods of the FACs are modulated by the oscillations but not exactly equal, which is one possible reason that the period of the Pi2 caused by the FACs could be different from the oscillations. We speculate that a current circuit between the plasma sheet and ionosphere can be formed during strongly tilted current sheet, and successive tilted current sheet could generate quasiperiodic multiple FAC systems, which can generate high-latitude Pi2 pulsations and control their periods.

Physics-based Control-oriented Modeling of the Current Profile Evolution in NSTX-Upgrade

NASA Astrophysics Data System (ADS)

Ilhan, Zeki; Barton, Justin; Shi, Wenyu; Schuster, Eugenio; Gates, David; Gerhardt, Stefan; Kolemen, Egemen; Menard, Jonathan

2013-10-01

The operational goals for the NSTX-Upgrade device include non-inductive sustainment of high- β plasmas, realization of the high performance equilibrium scenarios with neutral beam heating, and achievement of longer pulse durations. Active feedback control of the current profile is proposed to enable these goals. Motivated by the coupled, nonlinear, multivariable, distributed-parameter plasma dynamics, the first step towards feedback control design is the development of a physics-based, control-oriented model for the current profile evolution in response to non-inductive current drives and heating systems. For this purpose, the nonlinear magnetic-diffusion equation is coupled with empirical models for the electron density, electron temperature, and non-inductive current drives (neutral beams). The resulting first-principles-driven, control-oriented model is tailored for NSTX-U based on the PTRANSP predictions. Main objectives and possible challenges associated with the use of the developed model for control design are discussed. This work was supported by PPPL.

Dynamics of ion beam charge neutralization by ferroelectric plasma sources

DOE PAGES

Stepanov, Anton D.; Gilson, Erik P.; Grisham, Larry R.; ...

2016-04-27

Ferroelectric Plasma Sources (FEPSs) can generate plasma that provides effective space-charge neutralization of intense high-perveance ion beams, as has been demonstrated on the Neutralized Drift Compression Experiment NDCX-I and NDCX-II. This article presents experimental results on charge neutralization of a high-perveance 38 keV Ar + beam by a plasma produced in a FEPS discharge. By comparing the measured beam radius with the envelope model for space-charge expansion, it is shown that a charge neutralization fraction of 98% is attainable with sufficiently dense FEPS plasma. The transverse electrostatic potential of the ion beam is reduced from 15V before neutralization to 0.3more » V, implying that the energy of the neutralizing electrons is below 0.3 eV. Measurements of the time-evolution of beam radius show that near-complete charge neutralization is established similar to –5 μs after the driving pulse is applied to the FEPS and can last for 35 μs. It is argued that the duration of neutralization is much longer than a reasonable lifetime of the plasma produced in the sub-mu s surface discharge. Measurements of current flow in the driving circuit of the FEPS show the existence of electron emission into vacuum, which lasts for tens of mu s after the high voltage pulse is applied. Lastly, it is argued that the beam is neutralized by the plasma produced by this process and not by a surface discharge plasma that is produced at the instant the high-voltage pulse is applied.« less

Dynamics of Ion Beam Charge Neutralization by Ferroelectric Plasma Sources

NASA Astrophysics Data System (ADS)

Stepanov, Anton D.; Gilson, Erik P.; Grisham, Larry R.; Kaganovich, Igor D.; Davidson, Ronald C.; Ji, Qing; Persaud, Arun; Seidl, Peter A.; Schenkel, Thomas

2016-10-01

Ferroelectric Plasma Sources (FEPSs) can generate plasma that provides effective space-charge neutralization of intense high-perveance ion beams. Here we present experimental results on charge neutralization of a high-perveance 38 keV Ar+ beam by a FEPS plasma. By comparing the measured beam radius with the envelope model for space-charge expansion, it is shown that a charge neutralization fraction of 98% is attainable. The transverse electrostatic potential of the ion beam is reduced from 15 V before neutralization to 0.3 V, implying that the energy of the neutralizing electrons is below 0.3 eV. Near-complete charge neutralization is established 5 μs after the driving pulse is applied to the FEPS, and can last for 35 μs. It is argued that the duration of neutralization is much longer than a reasonable lifetime of the plasma produced in the sub- μs surface discharge. Measurements of current flow in the driving circuit of the FEPS suggest that plasma can be generated for tens of μs after the high voltage pulse is applied. This is confirmed by fast photography of the plasma in the 1-meter long FEPS on NDCX-II, where effective charge neutralization of the beam was achieved with the optimized FEPS timing. This work was supported by the Office of Science of the US Department of Energy under contracts DE-AC0209CH11466 (PPPL) and DE-AC0205CH11231 (LBNL).

Escape from neutralization by the respiratory syncytial virus-specific neutralizing monoclonal antibody palivizumab is driven by changes in on-rate of binding to the fusion protein

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bates, John T.; Keefer, Christopher J.; Slaughter, James C.

2014-04-15

The role of binding kinetics in determining neutralizing potency for antiviral antibodies is poorly understood. While it is believed that increased steady-state affinity correlates positively with increased virus-neutralizing activity, the relationship between association or dissociation rate and neutralization potency is unclear. We investigated the effect of naturally-occurring antibody resistance mutations in the RSV F protein on the kinetics of binding to palivizumab. Escape from palivizumab-mediated neutralization of RSV occurred with reduced association rate (K{sub on}) for binding to RSV F protein, while alteration of dissociation rate (K{sub off}) did not significantly affect neutralizing activity. Interestingly, linkage of reduced K{sub on}more » with reduced potency mirrored the effect of increased K{sub on} found in a high-affinity enhanced potency palivizumab variant (motavizumab). These data suggest that association rate is the dominant factor driving neutralization potency for antibodies to RSV F protein antigenic site A and determines the potency of antibody somatic variants or efficiency of escape of viral glycoprotein variants. - Highlights: • The relationship of affinity to neutralization for virus antibodies is uncertain. • Palivizumab binds to RSV escape mutant fusion proteins, but with reduced affinity. • Association rate (K{sub on}) correlated well with the potency of neutralization.« less

A fully human monoclonal antibody with novel binding epitope and excellent neutralizing activity to multiple human IFN-α subtypes: A candidate therapy for systemic lupus erythematosus.

PubMed

Du, Peng; Xu, Lei; Qiu, Weiyi; Zeng, Dadi; Yue, Junjie; Wang, Shuang; Huang, Peitang; Sun, Zhiwei

2015-01-01

Systemic lupus erythematosus (SLE) is a chronic, heterogeneous autoimmune disease short of effective therapeutic agents. A multitude of studies of SLE in the last decade have accentuated a central role of the interferon alpha (IFN-α) pathway in SLE pathogenesis. We report here a candidate therapeutic neutralizing antibody, AIA22, with a different binding epitope and discrepant neutralizing profile from the anti-multiple IFN-α subtype antibodies currently in clinical trials. AIA22 specifically interacts with multiple IFN-α subtypes, binds to the type I IFN receptor 2 (IFNAR2) recognition region of IFN-α (considered a novel antigen epitope), and effectively neutralizes the activity of almost all of the IFN-α subtypes (with the exception of IFN-α7) both in vitro and in vivo. Concurrently, structural modeling and computational design yielded a mutational antibody of AIA22, AIAmut, which exhibited substantially improved neutralizing activity to multiple IFN-α subtypes.

Heavy neutral leptons at FASER

NASA Astrophysics Data System (ADS)

Kling, Felix; Trojanowski, Sebastian

2018-05-01

We study the prospects for discovering heavy neutral leptons at Forward Search Experiment (FASER), the newly proposed detector at the LHC. Previous studies showed that a relatively small detector with ˜10 m length and ≲1 m2 cross sectional area can probe large unconstrained parts of parameter space for dark photons and dark Higgs bosons. In this work, we show that FASER will also be sensitive to heavy neutral leptons that have mixing angles with the active neutrinos that are up to an order of magnitude lower than current bounds. In particular, this is true for heavy neutral leptons produced dominantly in B -meson decays, in which case FASER's discovery potential is comparable to the proposed SHiP detector. We also illustrate how the search for heavy neutral leptons at FASER will be complementary to ongoing searches in high-pT experiments at the LHC and can shed light on the nature of dark matter and the process of baryogenesis in the early Universe.

Neutral Solar Wind Generated by Lunar Exospheric Dust at the Terminator

NASA Technical Reports Server (NTRS)

Collier, Michael R.; Stubbs, Timothy J.

2007-01-01

We calculate the flux of neutral solar wind observed on the lunar surface at the terminator due to solar wind protons penetrating exospheric dust with: (1) grains larger that 0.1 microns and (2) grains larger than 0.01 microns. For grains larger than 0.1 microns, the ratio of the neutral solar wind to solar wind flux is estimated to be approx.10(exp -4)-10(exp -3) at solar wind speeds in excess of 800 km/s, but much lower (less than 10(exp -5) at average to low solar wind speeds. However, when the smaller grain sizes are considered, the ratio of the neutral solar wind flux to solar wind flux is estimated to be greater than or equal to 10(exp -5) at all speeds and at speeds in excess of 700 km/s reaches 10(exp -3)-10(exp -2). These neutral solar wind fluxes are easily measurable with current low energy neutral atom instrumentation. Observations of neutral solar wind from the surface of the Moon could provide a very sensitive determination of the distribution of very small dust grains in the lunar exosphere and would provide data complementary to optical measurements at ultraviolet and visible wavelengths. Furthermore, neutral solar wind, unlike its ionized counterpart, is .not held-off by magnetic anomalies, and may contribute to greater space weathering than expected in certain lunar locations.

On charge exchange and knock-on processes in the exosphere of Io

NASA Technical Reports Server (NTRS)

Ip, W.-H.

1982-01-01

One direct consequence of magnetospheric interaction of Io is the strong dynamical coupling of its neutral atmosphere with the corotating plasma. The absorption of the thermal ions and the associated neutral injection is an improtant issue not yet explored. As far as nonthermal escape of the neutral atmosphere is concerned, three processes stand out. That is, apart from sputtering, exospheric interactions like atom-ion knock-on collision and charge exchange recombination could be a significant source of the neutral clouds in the Jovian system. Using a current electrodynamic model of Io, both the absorption rate of the corotating thermal plasma and the production rates of new exospheric ions and the fast neutrals are considered. It is found that the source strength of the neutral atoms and molecules with speeds of about 100 km/sec could amount to 10 to the 26th/sec whereas exospheric neutrals emitted at lower speed (of about 10 km/sec) amounts to 4 x 10 to the 25th/sec. The generation of the new ions in connection with the streaming of the magnetospheric plasma around Io could also produce an asymmetric sputtering with a neutral flux of about 10 to the 27th/sec emitted from the region of Io which faces Jupiter. These results may be related to a number of sodium observations.

The Response of Human Thermal Sensation and Its Prediction to Temperature Step-Change (Cool-Neutral-Cool)

PubMed Central

Du, Xiuyuan; Li, Baizhan; Liu, Hong; Yang, Dong; Yu, Wei; Liao, Jianke; Huang, Zhichao; Xia, Kechao

2014-01-01

This paper reports on studies of the effect of temperature step-change (between a cool and a neutral environment) on human thermal sensation and skin temperature. Experiments with three temperature conditions were carried out in a climate chamber during the period in winter. Twelve subjects participated in the experiments simulating moving inside and outside of rooms or cabins with air conditioning. Skin temperatures and thermal sensation were recorded. Results showed overshoot and asymmetry of TSV due to the step-change. Skin temperature changed immediately when subjects entered a new environment. When moving into a neutral environment from cool, dynamic thermal sensation was in the thermal comfort zone and overshoot was not obvious. Air-conditioning in a transitional area should be considered to limit temperature difference to not more than 5°C to decrease the unacceptability of temperature step-change. The linear relationship between thermal sensation and skin temperature or gradient of skin temperature does not apply in a step-change environment. There is a significant linear correlation between TSV and Qloss in the transient environment. Heat loss from the human skin surface can be used to predict dynamic thermal sensation instead of the heat transfer of the whole human body. PMID:25136808

What does brain response to neutral faces tell us about major depression? evidence from machine learning and fMRI.

PubMed

Oliveira, Leticia; Ladouceur, Cecile D; Phillips, Mary L; Brammer, Michael; Mourao-Miranda, Janaina

2013-01-01

A considerable number of previous studies have shown abnormalities in the processing of emotional faces in major depression. Fewer studies, however, have focused specifically on abnormal processing of neutral faces despite evidence that depressed patients are slow and less accurate at recognizing neutral expressions in comparison with healthy controls. The current study aimed to investigate whether this misclassification described behaviourally for neutral faces also occurred when classifying patterns of brain activation to neutral faces for these patients. TWO INDEPENDENT DEPRESSED SAMPLES: (1) Nineteen medication-free patients with depression and 19 healthy volunteers and (2) Eighteen depressed individuals and 18 age and gender-ratio-matched healthy volunteers viewed emotional faces (sad/neutral; happy/neutral) during an fMRI experiment. We used a new pattern recognition framework: first, we trained the classifier to discriminate between two brain states (e.g. viewing happy faces vs. viewing neutral faces) using data only from healthy controls (HC). Second, we tested the classifier using patterns of brain activation of a patient and a healthy control for the same stimuli. Finally, we tested if the classifier's predictions (predictive probabilities) for emotional and neutral face classification were different for healthy controls and depressed patients. Predictive probabilities to patterns of brain activation to neutral faces in both groups of patients were significantly lower in comparison to the healthy controls. This difference was specific to neutral faces. There were no significant differences in predictive probabilities to patterns of brain activation to sad faces (sample 1) and happy faces (samples 2) between depressed patients and healthy controls. Our results suggest that the pattern of brain activation to neutral faces in depressed patients is not consistent with the pattern observed in healthy controls subject to the same stimuli. This difference in brain activation might underlie the behavioural misinterpretation of the neutral faces content by the depressed patients.

A Statistical Model of the Magnetotail Neutral Sheet

NASA Astrophysics Data System (ADS)

Xiao, Sudong; Zhang, Tielong; Baumjohann, Wolfgang; Nakamura, Rumi; Ge, Yasong; Du, Aimin; Wang, Guoqiang; Lu, Quanming

2015-04-01

The neutral sheet of the magnetotail is characterized by weak magnetic field, strong cross tail current, and a reversal of the magnetic field direction across it. The dynamics of the earth's magnetosphere is greatly influenced by physical processes that occur near the neutral sheet. However, the exact position of the neutral sheet is variable in time. It is therefore essential to have a reliable estimate of the average position of the neutral sheet. Magnetic field data from ten years of Cluster, nineteen years of Geotail, four years of TC 1, and seven years of THEMIS observations have been incorporated to obtain a model of the magnetotail neutral sheet. All data in aberrated GSM (Geocentric Solar Magnetospheric) coordinate system are normalized to the same solar wind pressure condition. The shape and position of the neutral sheet, illustrated directly by the separator of positive and negative Bx on the YZ cross sections, are fitted with a displaced ellipse model. It is consistent with previous studies that the neutral sheet becomes curvier in the YZ cross section when the dipole tilt increases, yet our model shows the curviest neutral sheet compared with previous models. The new model reveals a hinging distance very close to 10 RE at a reference solar wind dynamic pressure of 2 nPa. We find that the earth dipole tilt angle not only affects the neutral sheet configuration in the YZ cross section but also in the XZ cross section. The neutral sheet becomes more tilting in the XZ cross section when the dipole tilt increases. The effect of an interplanetary magnetic field (IMF) penetration is studied, and an IMF By-related twisting of about 3° is found. Anticlockwise twisting of the neutral sheet is observed, looking along the downtail direction, for a positive IMF By, and clockwise twisting of the neutral sheet for a negative IMF By.

Attenuating the alcohol allure: attentional broadening reduces rapid motivational response to alcohol pictures.

PubMed

Ryerson, Nicole C; Neal, Lauren B; Gable, Philip A

2017-04-01

Past research has found that exposure to alcohol cues causes a narrowing of attentional scope and enhances the neural responses associated with approach motivation. The current research sought to determine if a manipulated broadened (global) attentional scope would reduce approach-motivated neural reactivity to alcohol pictures. In the current study, participants (n = 82) were exposed to alcohol and neutral pictures following either a global or local attentional scope manipulation. Early motivated attentional processing was assessed using the N1 event-related potential (ERP), a neurophysiological marker of rapid motivated attention. A global attentional scope reduced N1 amplitudes to alcohol pictures as compared to a local attentional scope. Self-reported binge drinking related to larger N1 amplitudes to alcohol pictures, but not to neutral pictures. Individuals with greater binge drinking experience demonstrated increased rapid motivated attentional processing to alcohol pictures. These results suggest that enhancing a global (vs. local) attentional scope attenuates rapid motivated attentional processing of alcohol pictures in comparison to neutral pictures. Graphical abstract ᅟ.

A review of studies on ion thruster beam and charge-exchange plasmas

NASA Technical Reports Server (NTRS)

Carruth, M. R., Jr.

1982-01-01

Various experimental and analytical studies of the primary beam and charge-exchange plasmas of ion thrusters are reviewed. The history of plasma beam research is recounted, emphasizing experiments on beam neutralization, expansion of the beam, and determination of beam parameters such as electron temperature, plasma density, and plasma potential. The development of modern electron bombardment ion thrusters is treated, detailing experimental results. Studies on charge-exchange plasma are discussed, showing results such as the relationship between neutralizer emission current and plasma beam potential, ion energies as a function of neutralizer bias, charge-exchange ion current collected by an axially moving Faraday cup-RPA for 8-cm and 30-cm ion thrusters, beam density and potential data from a 15-cm ion thruster, and charge-exchange ion flow around a 30-cm thruster. A 20-cm thruster electrical configuration is depicted and facility effects are discussed. Finally, plasma modeling is covered in detail for plasma beam and charge-exchange plasma.

Conflict transformation, stigma, and HIV-preventive structural change

PubMed Central

Miller, Robin Lin; Reed, Sarah J.; Francisco, Vincent T.; Ellen, Jonathan M.

2012-01-01

Over the prior decade, structural change efforts have become an important component of community-based HIV prevention initiatives. However, these efforts may not succeed when structural change initiatives encounter political resistance or invoke conflicting values, which may be likely when changes are intended to benefit a stigmatized population. The current study sought to examine the impact of target population stigma on the ability of 13 community coalitions to achieve structural change objectives. Results indicated that coalitions working on behalf of highly stigmatized populations had to abandon objectives more often than did coalitions working for less stigmatized populations because of external opposition to coalition objectives and resultant internal conflict over goals. Those coalitions that were most successful in meeting external challenges used opposition and conflict as transformative occasions by targeting conflicts directly and attempting to neutralize oppositional groups or turn them into strategic allies; less successful coalitions working on behalf of stigmatized groups struggled to determine an appropriate response to opposition. The role of conflict transformation as a success strategy for working on behalf of stigmatized groups is discussed. PMID:21805217

Mark My Words: Tone of Voice Changes Affective Word Representations in Memory

PubMed Central

Schirmer, Annett

2010-01-01

The present study explored the effect of speaker prosody on the representation of words in memory. To this end, participants were presented with a series of words and asked to remember the words for a subsequent recognition test. During study, words were presented auditorily with an emotional or neutral prosody, whereas during test, words were presented visually. Recognition performance was comparable for words studied with emotional and neutral prosody. However, subsequent valence ratings indicated that study prosody changed the affective representation of words in memory. Compared to words with neutral prosody, words with sad prosody were later rated as more negative and words with happy prosody were later rated as more positive. Interestingly, the participants' ability to remember study prosody failed to predict this effect, suggesting that changes in word valence were implicit and associated with initial word processing rather than word retrieval. Taken together these results identify a mechanism by which speakers can have sustained effects on listener attitudes towards word referents. PMID:20169154

DESTRUCTION OF NEUTRAL PARTICLES IN A DEVICE FOR PRODUCING A HIGH DENSITY PLASMA

DOEpatents

Simon, A.

1962-05-01

A method and apparatus are described for burning out neutral particles in an evacuated region and within a strong magnetic field. The method comprises injecting energetic molecular ions into the region perpendicular to the magnetic field and into the path of a dissociating, energetic arc discharge, the atomic ions formed in the dissociating process being trapped by the magnetic field, and then increasing the value of the trapped atomic ion current to such a value that the neutral particles are destroyed faster than they are formed, thereby causing a dense, energetic plasma to be built up and sustained by the magnetic field. (AEC)

A new type of single-phase five-level inverter

NASA Astrophysics Data System (ADS)

Xu, Zhi; Li, Shengnan; Qin, Risheng; Zhao, Yanhang

2017-11-01

At present, Neutral Point Clamped (NPC) multilevel inverter is widely applied in new energy field. However, it has some disadvantages including low utilization rate of direct current (DC) voltage source and the unbalance of neutral potential. Therefore, a new single-phase five level inverter is proposed in this paper. It has two stage structure, the former stage is equivalent to three level DC/DC converter, and the back stage uses H bridge to realize inverter. Compared with the original central clamp type inverter, the new five level inverter can improve the utilization of DC voltage, and realize the neutral point potential balance with hysteresis comparator.

Method and apparatus for executing a shift in a hybrid transmission

DOEpatents

Gupta, Pinaki; Kaminsky, Lawrence A; Demirovic, Besim

2013-09-03

A method for executing a transmission shift in a hybrid transmission including first and second electric machines includes executing a shift-through-neutral sequence from an initial transmission state to a target transmission state including executing an intermediate shift to neutral. Upon detecting a change in an output torque request while executing the shift-through-neutral sequence, possible recovery shift paths are identified. Available ones of the possible recovery shift paths are identified and a shift cost for each said available recovery shift path is evaluated. The available recovery shift path having a minimum shift cost is selected as a preferred recovery shift path and is executed to achieve a non-neutral transmission state.

Neutrino-nucleus neutral current elastic interactions measurement in MiniBooNE

NASA Astrophysics Data System (ADS)

Perevalov, Denis

The MiniBooNE experiment at the Fermi National Accelerator Laboratory (Fermilab) was designed to search for numu → nu e neutrino oscillations at Deltam 2 ˜ 1 eV2 using an intense neutrino flux with an average energy Enu ˜ 700 MeV. From 2002 to 2009 MiniBooNE has accumulated more than 1.0x1021 protons on target (POT) in both neutrino and antineutrino modes. MiniBooNE provides a perfect platform for detailed measurements of exclusive and semi-inclusive neutrino cross-sections, for which MiniBooNE has the largest samples of events up to date, such as neutral current elastic (NCE), neutral current pi 0, charged current quasi-elastic (CCQE), charged current pi +, and other channels. These measured cross-sections, in turn, allow to improve the knowledge of nucleon structure. This thesis is devoted to the study of NCE interactions. Neutrino-nucleus neutral current elastic scattering (nuN → nu N) accounts for about 18% of all neutrino interactions in MiniBooNE. Using a high-statistics, high purity sample of NCE interactions in MiniBooNE, the flux-averaged NCE differential cross-section has been measured and is being reported here. Further study of the NCE cross-section allowed for probing the structure of nuclei. The main interest in the NCE cross-section is that it may be sensitive to the strange quark contribution to the nucleon spin, Deltas, this however requires a separation of NCE proton (nup → nu p) from NCE neutron (nun → nun ) events, which in general is a challenging task. MiniBooNE uses a Cherenkov detector, which imposes restrictions on the measured nucleon kinematic variables, mainly due to the impossibility to reconstruct the nucleon direction below the Cherenkov threshold. However, at kinetic energies above this threshold MiniBooNE is able to identify NCE proton events that do not experience final state interactions (FSI). These events were used for the Deltas measurement. In this thesis MiniBooNE reports the NCE (n+p) cross-section, the measurement of the axial mass, MA, and the Delta s parameter from the NCE data.

Changes in the Bacterial Community of Soil from a Neutral Mine Drainage Channel

PubMed Central

Pereira, Letícia Bianca; Vicentini, Renato; Ottoboni, Laura M. M.

2014-01-01

Mine drainage is an important environmental disturbance that affects the chemical and biological components in natural resources. However, little is known about the effects of neutral mine drainage on the soil bacteria community. Here, a high-throughput 16S rDNA pyrosequencing approach was used to evaluate differences in composition, structure, and diversity of bacteria communities in samples from a neutral drainage channel, and soil next to the channel, at the Sossego copper mine in Brazil. Advanced statistical analyses were used to explore the relationships between the biological and chemical data. The results showed that the neutral mine drainage caused changes in the composition and structure of the microbial community, but not in its diversity. The Deinococcus/Thermus phylum, especially the Meiothermus genus, was in large part responsible for the differences between the communities, and was positively associated with the presence of copper and other heavy metals in the environmental samples. Other important parameters that influenced the bacterial diversity and composition were the elements potassium, sodium, nickel, and zinc, as well as pH. The findings contribute to the understanding of bacterial diversity in soils impacted by neutral mine drainage, and demonstrate that heavy metals play an important role in shaping the microbial population in mine environments. PMID:24796430

Changes in EEG spectral power on perception of neutral and emotional words in patients with schizophrenia, their relatives, and healthy subjects from the general population.

PubMed

Alfimova, M V; Uvarova, L G

2008-06-01

EEG correlates of impairments in the processing of emotiogenic information which might reflect a genetic predisposition to schizophrenia were sought by studying the dynamics of EEG rhythm powers on presentation of neutral and emotional words in 36 patients with schizophrenia, 50 of their unaffected first-degree relatives, and 47 healthy subjects without any inherited predisposition to psychoses. In controls, passive hearing of neutral words produced minimal changes in cortical rhythms, predominantly in the form of increases in the power levels of slow and fast waves, while perception of emotional words was accompanied by generalized reductions in the power of the alpha and beta(1) rhythms and regionally specific suppression of theta and beta(2) activity. Patients and their relatives demonstrated reductions in power of alpha and beta(1) activity, with an increase in delta power on hearing both groups of words. Thus, differences in responses to neutral and emotional words in patients and their relatives were weaker, because of increased reactions to neutral words. These results may identify EEG reflections of pathology of involuntary attention, which is familial and, evidently, inherited in nature. No reduction in reactions to emotiogenic stimuli was seen in patients' families.

Plasma density enhancements created by the ionization of the Earth's upper atmosphere by artificial electron beams

NASA Technical Reports Server (NTRS)

Neubert, Torsten; Banks, Peter M.

1990-01-01

Analytical calculations and experimental observations relating to the interaction with the Earth's upper atmosphere of electron beams emitted from low altitude spacecraft are presented. The problem is described by two coupled nonlinear differential equations in the up-going (along a magnetic field line) and down-going differential energy flux. The equations are solved numerically, using the MSIS atmospheric model and the IRI ionospheric model. The results form the model compare well with recent observations from the CHARGE 2 sounding rocket experiment. Two aspects of the beam-neutral atmosphere interaction are discussed. First, the limits on the electron beam current that can be emitted from a spacecraft without substantial spacecraft charging are investigated. This is important because the charging of the spacecraft to positive potentials limits the current and the escape energy of the beam electrons and thereby limits the ionization of the neutral atmosphere. As an example, we find from CHARGE 2 observations and from the model calculations that below about 180 km, secondary electrons generated through the ionization of the neutral atmosphere by 1 to 10 keV electron beams from sounding rockets, completely balance the beam current, thereby allowing the emission of very high beam currents. Second, the amount of plasma production in the beam-streak is discussed. Results are shown for selected values of the beam energy, spacecraft velocity, and spacecraft altitude.

Genetic depletion at adaptive but not neutral loci in an endangered bird species.

PubMed

Hartmann, Stefanie A; Schaefer, H Martin; Segelbacher, Gernot

2014-12-01

Many endangered species suffer from the loss of genetic diversity, but some populations may be able to thrive even if genetically depleted. To investigate the underlying genetic processes of population bottlenecks, we apply an innovative approach for assessing genetic diversity in the last known population of the endangered Pale-headed Brushfinch (Atlapetes pallidiceps) in Ecuador. First, we measure genetic diversity at eleven neutral microsatellite loci and adaptive SNP variation in five Toll-like receptor (TLR) immune system genes. Bottleneck tests confirm genetic drift as the main force shaping genetic diversity in this species and indicate a 99 % reduction in population size dating back several hundred years. Second, we compare contemporary microsatellite diversity with historic museum samples of A. pallidiceps, finding no change in genetic diversity. Third, we compare genetic diversity in the Pale-headed Brushfinch with two co-occurring-related brushfinch species (Atlapetes latinuchus, Buarremon torquatus), finding a reduction of up to 91% diversity in the immune system genes but not in microsatellites. High TLR diversity is linked to decreased survival probabilities in A. pallidiceps. Low TLR diversity is thus probably an adaptation to the specific selection regime within its currently very restricted distribution (approximately 200 ha), but could severely restrict the adaptive potential of the species in the long run. Our study illustrates the importance of investigating both neutral and adaptive markers to assess the effect of population bottlenecks and for recommending specific management plans in endangered species. © 2014 John Wiley & Sons Ltd.

Emotion strengthens high priority memory traces but weakens low priority memory traces

PubMed Central

Sakaki, Michiko; Fryer, Kellie; Mather, Mara

2014-01-01

When encountering emotional events, memory for those events is typically enhanced. But it has been unclear how emotionally arousing events influence memory for preceding information. Does emotional arousal induce retrograde amnesia or retrograde enhancement? The current study revealed that this depends on the top-down goal relevance of the preceding information. Across three studies, we found that emotional arousal induced by one image facilitated memory for the preceding neutral item when people prioritized that neutral item. In contrast, an emotional image impaired memory for the preceding neutral item when people did not prioritize that neutral item. Emotional arousal elicited by negative and positive pictures both showed this pattern of enhancing or impairing memory for the preceding stimulus depending on its priority. These results indicate that emotional arousal amplifies the effects of top-down priority in memory formation. PMID:24311478

Theoretical analysis of co-solvent effect on the proton transfer reaction of glycine in a water–acetonitrile mixture

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kasai, Yukako; Yoshida, Norio, E-mail: noriwo@chem.kyushu-univ.jp; Nakano, Haruyuki

2015-05-28

The co-solvent effect on the proton transfer reaction of glycine in a water–acetonitrile mixture was examined using the reference interaction-site model self-consistent field theory. The free energy profiles of the proton transfer reaction of glycine between the carboxyl oxygen and amino nitrogen were computed in a water–acetonitrile mixture solvent at various molar fractions. Two types of reactions, the intramolecular proton transfer and water-mediated proton transfer, were considered. In both types of the reactions, a similar tendency was observed. In the pure water solvent, the zwitterionic form, where the carboxyl oxygen is deprotonated while the amino nitrogen is protonated, is moremore » stable than the neutral form. The reaction free energy is −10.6 kcal mol{sup −1}. On the other hand, in the pure acetonitrile solvent, glycine takes only the neutral form. The reaction free energy from the neutral to zwitterionic form gradually increases with increasing acetonitrile concentration, and in an equally mixed solvent, the zwitterionic and neutral forms are almost isoenergetic, with a difference of only 0.3 kcal mol{sup −1}. The free energy component analysis based on the thermodynamic cycle of the reaction also revealed that the free energy change of the neutral form is insensitive to the change of solvent environment but the zwitterionic form shows drastic changes. In particular, the excess chemical potential, one of the components of the solvation free energy, is dominant and contributes to the stabilization of the zwitterionic form.« less

Stochastic Spatial Models in Ecology: A Statistical Physics Approach

NASA Astrophysics Data System (ADS)

Pigolotti, Simone; Cencini, Massimo; Molina, Daniel; Muñoz, Miguel A.

2018-07-01

Ecosystems display a complex spatial organization. Ecologists have long tried to characterize them by looking at how different measures of biodiversity change across spatial scales. Ecological neutral theory has provided simple predictions accounting for general empirical patterns in communities of competing species. However, while neutral theory in well-mixed ecosystems is mathematically well understood, spatial models still present several open problems, limiting the quantitative understanding of spatial biodiversity. In this review, we discuss the state of the art in spatial neutral theory. We emphasize the connection between spatial ecological models and the physics of non-equilibrium phase transitions and how concepts developed in statistical physics translate in population dynamics, and vice versa. We focus on non-trivial scaling laws arising at the critical dimension D = 2 of spatial neutral models, and their relevance for biological populations inhabiting two-dimensional environments. We conclude by discussing models incorporating non-neutral effects in the form of spatial and temporal disorder, and analyze how their predictions deviate from those of purely neutral theories.

Stochastic Spatial Models in Ecology: A Statistical Physics Approach

NASA Astrophysics Data System (ADS)

Pigolotti, Simone; Cencini, Massimo; Molina, Daniel; Muñoz, Miguel A.

2017-11-01

Ecosystems display a complex spatial organization. Ecologists have long tried to characterize them by looking at how different measures of biodiversity change across spatial scales. Ecological neutral theory has provided simple predictions accounting for general empirical patterns in communities of competing species. However, while neutral theory in well-mixed ecosystems is mathematically well understood, spatial models still present several open problems, limiting the quantitative understanding of spatial biodiversity. In this review, we discuss the state of the art in spatial neutral theory. We emphasize the connection between spatial ecological models and the physics of non-equilibrium phase transitions and how concepts developed in statistical physics translate in population dynamics, and vice versa. We focus on non-trivial scaling laws arising at the critical dimension D = 2 of spatial neutral models, and their relevance for biological populations inhabiting two-dimensional environments. We conclude by discussing models incorporating non-neutral effects in the form of spatial and temporal disorder, and analyze how their predictions deviate from those of purely neutral theories.

Induction of neutral endopeptidase (NEP) activity of SK-N-SH cells by natural compounds from green tea.

PubMed

Ayoub, Shereen; Melzig, Matthias F

2006-04-01

Deposition of amyloid beta-peptide as senile plaques in the brain is one of the neuropathological hallmarks of Alzheimer's disease, which is the most prevalent progressive neurodegenerative disease leading to dementia. Neutral endopeptidase is one of the major beta-amyloid-degrading enzymes in the brain. To examine the influence of different polyphenols and other natural products from green tea extract (from Camellia sinensis, Theaceae), we used the neuroblastoma cell line SK-N-SH and studied the changes in the specific cellular neutral endopeptidase activity after long-term treatment with these substances. We have shown that caffeine leads to an increase in specific cellular neutral endopeptidase activity more than theophylline, theobromine or theanine. We have also shown that the combination of epicatechin, epigallocatechin and epigallocatechingallate with caffeine, theobromine or theophylline induced cellular neutral endopeptidase activity. It is suggested that the enhancement of cellular neutral endopeptidase activity by green tea extract and its natural products might be correlated with an elevated level of intracellular cyclic adenosine monophosphate.

A Neutral Network based Early Eathquake Warning model in California region

NASA Astrophysics Data System (ADS)

Xiao, H.; MacAyeal, D. R.

2016-12-01

Early Earthquake Warning systems could reduce loss of lives and other economic impact resulted from natural disaster or man-made calamity. Current systems could be further enhanced by neutral network method. A 3 layer neural network model combined with onsite method was deployed in this paper to improve the recognition time and detection time for large scale earthquakes.The 3 layer neutral network early earthquake warning model adopted the vector feature design for sample events happened within 150 km radius of the epicenters. Dataset used in this paper contained both destructive events and small scale events. All the data was extracted from IRIS database to properly train the model. In the training process, backpropagation algorithm was used to adjust the weight matrices and bias matrices during each iteration. The information in all three channels of the seismometers served as the source in this model. Through designed tests, it was indicated that this model could identify approximately 90 percent of the events' scale correctly. And the early detection could provide informative evidence for public authorities to make further decisions. This indicated that neutral network model could have the potential to strengthen current early warning system, since the onsite method may greatly reduce the responding time and save more lives in such disasters.

Amino acid codes in mitochondria as possible clues to primitive codes

NASA Technical Reports Server (NTRS)

Jukes, T. H.

1981-01-01

Differences between mitochondrial codes and the universal code indicate that an evolutionary simplification has taken place, rather than a return to a more primitive code. However, these differences make it evident that the universal code is not the only code possible, and therefore earlier codes may have differed markedly from the previous code. The present universal code is probably a 'frozen accident.' The change in CUN codons from leucine to threonine (Neurospora vs. yeast mitochondria) indicates that neutral or near-neutral changes occurred in the corresponding proteins when this code change took place, caused presumably by a mutation in a tRNA gene.

Implications of Deep Decarbonization for Carbon Cycle Science

NASA Astrophysics Data System (ADS)

Jones, A. D.; Williams, J.; Torn, M. S.

2016-12-01

The energy-system transformations required to achieve deep decarbonization in the United States, defined as a reduction of greenhouse gas emissions of 80% or more below 1990 levels by 2050, have profound implications for carbon cycle science, particularly with respect to 4 key objectives: understanding and enhancing the terrestrial carbon sink, using bioenergy sustainably, controlling non-CO2 GHGs, and emissions monitoring and verification. (1) As a source of mitigation, the terrestrial carbon sink is pivotal but uncertain, and changes in the expected sink may significantly affect the overall cost of mitigation. Yet the dynamics of the sink under changing climatic conditions, and the potential to protect and enhance the sink through land management, are poorly understood. Policy urgently requires an integrative research program that links basic science knowledge to land management practices. (2) Biomass resources can fill critical energy needs in a deeply decarbonized system, but current understanding of sustainability and lifecycle carbon aspects is limited. Mitigation policy needs better understanding of the sustainable amount, types, and cost of bioenergy feedstocks, their interactions with other land uses, and more efficient and reliable monitoring of embedded carbon. (3) As CO2 emissions from energy decrease under deep decarbonization, the relative share of non-CO2 GHGs grows larger and their mitigation more important. Because the sources tend to be distributed, variable, and uncertain, they have been under-researched. Policy needs a better understanding of mitigation priorities and costs, informed by deeper research in key areas such as fugitive CH4, fertilizer-derived N2O, and industrial F-gases. (4) The M&V challenge under deep decarbonization changes with a steep decrease in the combustion CO2 sources due to widespread electrification, while a greater share of CO2 releases is net-carbon-neutral. Similarly, gas pipelines may carry an increasing share of methane from biogenic or other net carbon-neutral sources. Improved lifecycle analysis will be needed to verify carbon neutrality, while the signal-to-noise challenge for attributing CO2 to fossil or biogenic fuels becomes more challenging.

Induced charging of shuttle orbiter by high electron-beam currents

NASA Technical Reports Server (NTRS)

Liemohn, H. B.

1977-01-01

Emission of high-current electron beams that was proposed for some Spacelab payloads required substantial return currents to the orbiter skin in order to neutralize the beam charge. Since the outer skin of the vehicle was covered with approximately 1200 sq m of thermal insulation which has the dielectric quality of air and an electrical conductivity that was estimated by NASA at 10 to the -9 power to 10 to the -10 power mhos/m, considerable transient charging and local potential differences were anticipated across the insulation. The theory for induced charging of spacecraft due to operation of electron guns was only developed for spherical metal vehicles and constant emission currents, which were not directly applicable to the orbiter situation. Field-aligned collection of electron return current from the ambient ionosphere at orbiter altitudes provides up to approximately 150 mA on the conducting surfaces and approximately 2.4 A on the dielectric thermal insulation. Local ionization of the neutral atmosphere by energetic electron bombardment or electrical breakdown may provide somewhat more return current.

Effect of molecular anisotropy on the intensity and degree of polarization of light scattered from model atmospheres

NASA Technical Reports Server (NTRS)

Bahethi, O. P.; Fraser, R. S.

1975-01-01

Computations of the intensity, flux, degree of polarization, and the positions of neutral points are presented for models of the terrestrial gaseous and hazy atmospheres by incorporating the molecular anisotropy due to air in the Rayleigh scattering optical thickness and phase matrix. Molecular anisotropy causes significant changes in the intensity, flux and the degree of polarization of the scattered light. The positions of neutral points do not change significantly. When the Rayleigh scattering optical thickness is kept constant and the molecular anisotropy factor is included only in the Rayleigh phase matrix, the flux does not change and the intensity and positions of neutron points change by a small amount. The changes in the degree of polarization are still significant.

PGV04, an HIV-1 gp120 CD4 Binding Site Antibody, Is Broad and Potent in Neutralization but Does Not Induce Conformational Changes Characteristic of CD4

PubMed Central

Falkowska, Emilia; Ramos, Alejandra; Feng, Yu; Zhou, Tongqing; Moquin, Stephanie; Walker, Laura M.; Wu, Xueling; Seaman, Michael S.; Wrin, Terri; Kwong, Peter D.; Wyatt, Richard T.; Mascola, John R.; Poignard, Pascal

2012-01-01

Recently, several broadly neutralizing monoclonal antibodies (bnMAbs) directed to the CD4-binding site (CD4bs) of gp120 have been isolated from HIV-1-positive donors. These include VRC01, 3BNC117, and NIH45-46, all of which are capable of neutralizing about 90% of circulating HIV-1 isolates and all of which induce conformational changes in the HIV-1 gp120 monomer similar to those induced by the CD4 receptor. In this study, we characterize PGV04 (also known as VRC-PG04), a MAb with potency and breadth that rivals those of the prototypic VRC01 and 3BNC117. When screened on a large panel of viruses, the neutralizing profile of PGV04 was distinct from those of CD4, b12, and VRC01. Furthermore, the ability of PGV04 to neutralize pseudovirus containing single alanine substitutions exhibited a pattern distinct from those of the other CD4bs MAbs. In particular, substitutions D279A, I420A, and I423A were found to abrogate PGV04 neutralization. In contrast to VRC01, PGV04 did not enhance the binding of 17b or X5 to their epitopes (the CD4-induced [CD4i] site) in the coreceptor region on the gp120 monomer. Furthermore, in contrast to CD4, none of the anti-CD4bs MAbs induced the expression of the 17b epitope on cell surface-expressed cleaved Env trimers. We conclude that potent CD4bs bnMAbs can display differences in the way they recognize and access the CD4bs and that mimicry of CD4, as assessed by inducing conformational changes in monomeric gp120 that lead to enhanced exposure of the CD4i site, is not uniquely correlated with effective neutralization at the site of CD4 binding on HIV-1. PMID:22345481

Contributions of fluid convection and electrical migration to transport in cartilage: relevance to loading.

PubMed

Garcia, A M; Frank, E H; Grimshaw, P E; Grodzinsky, A J

1996-09-15

We have studied the contributions of diffusion, fluid flow and electrical migration to molecular transport through adult articular cartilage explants using neutral and charged solutes that were either radiolabeled (3H2O, [35S]sulfate, [3H]thymidine, [3H]raffinose, and a synthetic matrix metalloproteinase inhibitor) or fluorescently tagged (NSPA and Lissamine-dextran). In order to induce fluid flow within the cartilage matrix without mechanical deformation, electric current densities were applied across cartilage disks. These currents produced electroosmotic fluid velocities of 1-2 microns/s, magnitudes that have been reported to exist during joint loading in vivo. This fluid convection enhanced neutral solute flux relative to passive diffusion alone by a factor that increased with the size of the solute. While the enhancement factor for 3H2O was 2.3-fold, that for [3H]raffinose (594 Da) and similar sized neutral solutes was 10-fold, suggesting that the effect of fluid flow is important even for small solutes. The largest enhancement (25-fold) was seen for the neutral 10-kDa Lissamine-dextran, confirming that fluid convection is most important for large solutes. We also studied the electrophoretic contribution to solute flux, which is relevant to the presence of intratissue streaming potentials induced during loading in vivo. Using the negatively charged [35S]sulfate ion with a range of current densities, as much as a 10-fold enhancement in flux was observed. Values for the intrinsic transport properties of the solutes (e.g., diffusivity, electrical mobility, hydrodynamic hindrance factor) can be obtained from the data.

If It's Neutral, It's Not Technology

ERIC Educational Resources Information Center

Strate, Lance

2012-01-01

Taking a media ecology perspective, this article argues that technology cannot be neutral, because it is a form of change, and it has an inherent bias based on the properties of its materials and methods. Additionally, the application of a technology is an intrinsic part of the technology itself, as is technique, instructions, software, or…

Genetic and Environmental Influences on Girls' and Boys' Gender-Typed and Gender-Neutral Values

ERIC Educational Resources Information Center

Knafo, Ariel; Spinath, Frank M.

2011-01-01

In this first investigation of genetic and environmental influences on children's values, 271 German twin pairs (50.2% boys) reported their values at ages 7-11 years using the Portrait Values Questionnaire (Schwartz & Rubel, 2005). We distinguished between gender-neutral (conservation vs. openness to change) and gender-typed…

Role of parafovea in blur perception.

PubMed

Venkataraman, Abinaya Priya; Radhakrishnan, Aiswaryah; Dorronsoro, Carlos; Lundström, Linda; Marcos, Susana

2017-09-01

The blur experienced by our visual system is not uniform across the visual field. Additionally, lens designs with variable power profile such as contact lenses used in presbyopia correction and to control myopia progression create variable blur from the fovea to the periphery. The perceptual changes associated with varying blur profile across the visual field are unclear. We therefore measured the perceived neutral focus with images of different angular subtense (from 4° to 20°) and found that the amount of blur, for which focus is perceived as neutral, increases when the stimulus was extended to cover the parafovea. We also studied the changes in central perceived neutral focus after adaptation to images with similar magnitude of optical blur across the image or varying blur from center to the periphery. Altering the blur in the periphery had little or no effect on the shift of perceived neutral focus following adaptation to normal/blurred central images. These perceptual outcomes should be considered while designing bifocal optical solutions for myopia or presbyopia. Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.

Hydrogen-bonding effect on spin-center transfer of tetrathiafulvalene-linked 6-oxophenalenoxyl evaluated using temperature-dependent cyclic voltammetry and theoretical calculations.

PubMed

Nishida, Shinsuke; Fukui, Kozo; Morita, Yasushi

2014-02-01

The stable tetrathiafulvalene (TTF)-linked 6-oxophenalenoxyl neutral radical exhibits a spin-center transfer with a continuous color change in solution caused by an intramolecular electron transfer, which is dependent on solvent and temperature. Cyclic voltammetry measurements showed that addition of 2,2,2-trifluoroethanol (TFE) to a benzonitrile solution of the neutral radical induces a redox potential shift that is favorable for the spin-center transfer. Temperature-dependent cyclic voltammetry of the neutral radical using a novel low-temperature electrochemical cell demonstrated that the redox potentials change with decreasing temperature in a 199:1 CH2Cl2/TFE mixed solvent. Furthermore, theoretical calculation revealed that the energy levels of the frontier molecular orbitals involved in the spin-center transfer are lowered by the hydrogen-bonding interaction of TFE with the neutral radical. These results indicate that the hydrogen-bonding effect is a key factor for the occurrence of the spin-center transfer of TTF-linked 6-oxophenalenoxyl. Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

A measurement of perpendicular current density in an aurora

NASA Technical Reports Server (NTRS)

Bering, E. A.; Mozer, F. S.

1975-01-01

A Nike Tomahawk sounding rocket was launched into a 400-gamma auroral substorm from Esrange, Kiruna, Sweden. The rocket instrumentation included a split Langmuir-probe plasma-velocity detector and a double-probe electric-field detector. Above 140-km altitude, the electric field deduced from the ion-flow velocity measurement and the electric field measured by the double probe agree to an accuracy within the uncertainties of the two measurements. The difference between the two measurements at altitudes below 140 km provides an in situ measurement of current density and conductivity. Alternatively, if values for the conductivity are assumed, the neutral-wind velocity can be deduced. The height-integrated current was 0.11 A/m flowing at an azimuth angle of 276 deg. The neutral winds were strong, exhibited substantial altitude variation in the east-west component, and were predominantly southward.

Equatorial F region neutral winds and shears near sunset measured with chemical release techniques

NASA Astrophysics Data System (ADS)

Kiene, A.; Larsen, M. F.; Kudeki, E.

2015-10-01

The period near sunset is a dynamic and critical time for the daily development of the equatorial nighttime ionosphere and the instabilities that occur there. It is during these hours that the preconditions necessary for the later development of Equatorial Spread F (ESF) plasma instabilities occur. The neutral dynamics of the sunset ionosphere are also of critical importance to the generation of currents and electric fields; however, the behavior of the neutrals is experimentally understood primarily through very limited single-altitude measurements or measurements that provide weighted altitude means of the winds as a function of time. To date, there have been very few vertically resolved neutral wind measurements in the F region at sunset. We present two sets of sounding rocket chemical release measurements, one from a launch in the Marshall Islands on Kwajalein atoll and one from Alcantara, Brazil. Analysis of the release motions has yielded vertically resolved neutral wind profiles that show both the mean horizontal winds and the vertical shears in the winds. In both experiments, we observe significant vertical gradients in the zonal wind that are unexpected by classical assumptions about the behavior of the neutral wind at these altitudes at sunset near the geomagnetic equator.

Long-term geomagnetically induced current observations in New Zealand: Earth return corrections and geomagnetic field driver

NASA Astrophysics Data System (ADS)

Mac Manus, Daniel H.; Rodger, Craig J.; Dalzell, Michael; Thomson, Alan W. P.; Clilverd, Mark A.; Petersen, Tanja; Wolf, Moritz M.; Thomson, Neil R.; Divett, Tim

2017-08-01

Transpower New Zealand Limited has measured DC currents in transformer neutrals in the New Zealand electrical network at multiple South Island locations. Near-continuous archived DC current data exist since 2001, starting with 12 different substations and expanding from 2009 to include 17 substations. From 2001 to 2015 up to 58 individual transformers were simultaneously monitored. Primarily, the measurements were intended to monitor the impact of the high-voltage DC system linking the North and South Islands when it is operating in "Earth return" mode. However, after correcting for Earth return operation, as described here, the New Zealand measurements provide an unusually long and spatially detailed set of geomagnetically induced current (GIC) measurements. We examine the peak GIC magnitudes observed from these observations during two large geomagnetic storms on 6 November 2001 and 2 October 2013. Currents of 30-50 A are observed, depending on the measurement location. There are large spatial variations in the GIC observations over comparatively small distances, which likely depend upon network layout and ground conductivity. We then go on to examine the GIC in transformers throughout the South Island during more than 151 h of geomagnetic storm conditions. We compare the GIC to the various magnitude and rate of change components of the magnetic field. Our results show that there is a strong correlation between the magnitude of the GIC and the rate of change of the horizontal magnetic field (H'). This correlation is particularly clear for transformers that show large GIC current during magnetic storms.

A new method for large-scale assessment of change in ecosystem functioning in relation to land degradation

NASA Astrophysics Data System (ADS)

Horion, Stephanie; Ivits, Eva; Verzandvoort, Simone; Fensholt, Rasmus

2017-04-01

Ongoing pressures on European land are manifold with extreme climate events and non-sustainable use of land resources being amongst the most important drivers altering the functioning of the ecosystems. The protection and conservation of European natural capital is one of the key objectives of the 7th Environmental Action Plan (EAP). The EAP stipulates that European land must be managed in a sustainable way by 2020 and the UN Sustainable development goals define a Land Degradation Neutral world as one of the targets. This implies that land degradation (LD) assessment of European ecosystems must be performed repeatedly allowing for the assessment of the current state of LD as well as changes compared to a baseline adopted by the UNCCD for the objective of land degradation neutrality. However, scientifically robust methods are still lacking for large-scale assessment of LD and repeated consistent mapping of the state of terrestrial ecosystems. Historical land degradation assessments based on various methods exist, but methods are generally non-replicable or difficult to apply at continental scale (Allan et al. 2007). The current lack of research methods applicable at large spatial scales is notably caused by the non-robust definition of LD, the scarcity of field data on LD, as well as the complex inter-play of the processes driving LD (Vogt et al., 2011). Moreover, the link between LD and changes in land use (how land use changes relates to change in vegetation productivity and ecosystem functioning) is not straightforward. In this study we used the segmented trend method developed by Horion et al. (2016) for large-scale systematic assessment of hotspots of change in ecosystem functioning in relation to LD. This method alleviates shortcomings of widely used linear trend model that does not account for abrupt change, nor adequately captures the actual changes in ecosystem functioning (de Jong et al. 2013; Horion et al. 2016). Here we present a new methodology for assessing gradual and abrupt changes in ecosystem functioning in Europe. Based on segmented trend analysis of water-use efficiency (WUE) time series, an Ecosystem Change Type (ECT) map was produced over Europe at 1km resolution for the period 1999 to 2013. An analysis of auxiliary data on land use/cover change, drought trends, and soil threats was performed over hotspot areas to better understand the observed changes in ecosystem functioning and their driving mechanisms. The ECT map was validated using the case study sites from the EU-funded RECARE project. Overall, the ECT map accurately highlighted areas characterized by a major change in pathways of ecosystem functioning as well as indicated the type and timing of changes. Allan, R. et al. (2007). Climate and land degradation. Verlag Berlin Heidelberg: Springer. de Jong, R et al. (2013). Remote Sensing, 5, 1117-1133 Horion, S. et al. (2016). Global Change Biology, 22, 2801-2817 Vogt, J. V et al. (2011). Land Degradation & Development, 22: 150-165.

Combined Effect of Alternating Current Interference and Cathodic Protection on Pitting Corrosion and Stress Corrosion Cracking Behavior of X70 Pipeline Steel in Near-Neutral pH Environment.

PubMed

Wang, Liwei; Cheng, Lianjun; Li, Junru; Zhu, Zhifu; Bai, Shuowei; Cui, Zhongyu

2018-03-22

Influence of alternating current (AC) on pitting corrosion and stress corrosion cracking (SCC) behavior of X70 pipeline steel in the near-neutral pH environment under cathodic protection (CP) was investigated. Both corrosion and SCC are inhibited by -0.775 V SCE CP without AC interference. With the superimposition of AC current (1-10 mA/cm²), the direct current (DC) potential shifts negatively under the CP of -0.775 V SCE and the cathodic DC current decreases and shifts to the anodic direction. Under the CP potential of -0.95 V SCE and -1.2 V SCE , the applied AC current promotes the cathodic reaction and leads to the positive shift of DC potential and increase of cathodic current. Local anodic dissolution occurs attributing to the generated anodic current transients in the positive half-cycle of the AC current, resulting in the initiation of corrosion pits (0.6-2 μm in diameter). AC enhances the SCC susceptibility of X70 steel under -0.775 V SCE CP, attributing to the promotion of anodic dissolution and hydrogen evolution. Even an AC current as low as 1 mA/cm² can enhance the SCC susceptibility.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Calva-Tellez, E.; Zepeda, A.

We discuss how weak neutral currents of popular gauge models manifest themselves in the process e/sup +/e/sup -/ ..-->.. ..pi../sup +/..pi../sup -/..pi../sup 0/ for an unpolarized initial state. We define three asymmetry parameters, A/sub c1/, A/sub c2/, and A/sub p/, which provide information about the presence of the neutral current. The former two give account of charge asymmetries in the ..pi../sup +/..pi../sup -/ final state, while A/sub p/ is nonzero when parity-violating effects occur. Using a phenomenological model for the hadronic vertices, we obtain that the maximum value of these parameters is approx. 3 to 4%, and that this valuemore » is reached at a beam energy approx. = 20 GeV. (AIP)« less

Strongly Enhanced Tunneling at Total Charge Neutrality in Double-Bilayer Graphene-WSe_{2} Heterostructures.

PubMed

Burg, G William; Prasad, Nitin; Kim, Kyounghwan; Taniguchi, Takashi; Watanabe, Kenji; MacDonald, Allan H; Register, Leonard F; Tutuc, Emanuel

2018-04-27

We report the experimental observation of strongly enhanced tunneling between graphene bilayers through a WSe_{2} barrier when the graphene bilayers are populated with carriers of opposite polarity and equal density. The enhanced tunneling increases sharply in strength with decreasing temperature, and the tunneling current exhibits a vertical onset as a function of interlayer voltage at a temperature of 1.5 K. The strongly enhanced tunneling at overall neutrality departs markedly from single-particle model calculations that otherwise match the measured tunneling current-voltage characteristics well, and suggests the emergence of a many-body state with condensed interbilayer excitons when electrons and holes of equal densities populate the two layers.

Strongly Enhanced Tunneling at Total Charge Neutrality in Double-Bilayer Graphene-WSe2 Heterostructures

NASA Astrophysics Data System (ADS)

Burg, G. William; Prasad, Nitin; Kim, Kyounghwan; Taniguchi, Takashi; Watanabe, Kenji; MacDonald, Allan H.; Register, Leonard F.; Tutuc, Emanuel

2018-04-01

We report the experimental observation of strongly enhanced tunneling between graphene bilayers through a WSe2 barrier when the graphene bilayers are populated with carriers of opposite polarity and equal density. The enhanced tunneling increases sharply in strength with decreasing temperature, and the tunneling current exhibits a vertical onset as a function of interlayer voltage at a temperature of 1.5 K. The strongly enhanced tunneling at overall neutrality departs markedly from single-particle model calculations that otherwise match the measured tunneling current-voltage characteristics well, and suggests the emergence of a many-body state with condensed interbilayer excitons when electrons and holes of equal densities populate the two layers.

Stability and confinement improvement of an oblate field-reversed configuration by using neutral beam injection

NASA Astrophysics Data System (ADS)

T., Ii; Inomoto, M.; Gi, K.; Umezawa, T.; Ito, T.; Kadowaki, K.; Kaminou, Y.; Ono, Y.

2013-07-01

A low-energy, high-current neutral beam injection (NBI) was applied to an oblate field-reversed configuration (FRC) for the first time. The NB fast ions reduce growth rates of low-n modes dangerous for the oblate FRC, extending the FRC lifetime by a factor of 1.2. The reduced loss power of 5 MW is much higher than the NBI power of 0.5 MW, indicating that the NBI not only heats the FRC plasma but also improves its stability and transport properties. The NBI also maintains higher pressure and current density profiles of the FRC, improving its flux and energy decay times by a factor of 2.

Calculation of conductivities and currents in the ionosphere

NASA Technical Reports Server (NTRS)

Kirchhoff, V. W. J. H.; Carpenter, L. A.

1975-01-01

Formulas and procedures to calculate ionospheric conductivities are summarized. Ionospheric currents are calculated using a semidiurnal E-region neutral wind model and electric fields from measurements at Millstone Hill. The results agree well with ground based magnetogram records for magnetic quiet days.

Quantum field-theoretical description of neutrino and neutral kaon oscillations

NASA Astrophysics Data System (ADS)

Volobuev, Igor P.

2018-05-01

It is shown that the neutrino and neutral kaon oscillation processes can be consistently described in quantum field theory using only plane waves of the mass eigenstates of neutrinos and neutral kaons. To this end, the standard perturbative S-matrix formalism is modified so that it can be used for calculating the amplitudes of the processes passing at finite distances and finite time intervals. The distance-dependent and time-dependent parts of the amplitudes of the neutrino and neutral kaon oscillation processes are calculated and the results turn out to be in accordance with those of the standard quantum mechanical description of these processes based on the notion of neutrino flavor states and neutral kaon states with definite strangeness. However, the physical picture of the phenomena changes radically: now, there are no oscillations of flavor or definite strangeness states, but, instead of it, there is interference of amplitudes due to different virtual mass eigenstates.

Application of the E - Turbulence Closure Model to the Neutral and Stable Atmospheric Boundary Layer.

NASA Astrophysics Data System (ADS)

Duynkerke, P. G.

1988-03-01

In the E - turbulence model an eddy-exchange coefficient is evaluated from the turbulent kinetic energy E and viscous dissipation . In this study we will apply the E - model to the stable and neutral atmospheric boundary layer. A discussion is given on the equation for , which terms should be included and how we have evaluated the constants. Constant cooling rate results for the stable atmospheric boundary layer are compared with a second-order closure study. For the neutral atmospheric boundary layer a comparison is made with observations, large-eddy simulations and a second-order closure study. It is shown that a small stability effect can change the neutral atmospheric boundary layer quite drastically, and therefore, it will be difficult to observe a neutral boundary layer in the atmosphere.

Investigation of Sterilization Mechanism for Geobacillus stearothermophilus Spores with Plasma-Excited Neutral Gas

NASA Astrophysics Data System (ADS)

Matsui, Kei; Ikenaga, Noriaki; Sakudo, Noriyuki

2015-09-01

We investigate the mechanism of the sterilization with plasma-excited neutral gas that uniformly sterilizes both the space and inner wall of the reactor chamber at atmospheric pressure. Only reactive neutral species such as plasma-excited gas molecules and radicals are separated from the plasma and sent to the reactor chamber for chemical sterilization. The plasma source gas uses humidified mixture of nitrogen and oxygen. Geobacillus stearothermophilus spores and tyrosine which is amino acid are treated by the plasma-excited neutral gas. Shape change of the treated spore is observed by SEM, and chemical modification of the treated tyrosine is analyzed by HPLC. As a result, the surface of the treated spore shows depression. Hydroxylation and nitration of tyrosine are shown after the treatment. For these reasons, we believe that the sterilization with plasma-excited neutral gas results from the deformation of spore structure due to the chemical modification of amino acid.

Effects of convincing power and neutrality on minority opinion spreading

NASA Astrophysics Data System (ADS)

Wu, Yue; Xiong, Xi; Zhang, Yi

2017-02-01

The dynamics evolution of the minority opinion in public debates is studied using a convincing power (CP) model with neutrality. In a given group, an agent with a definite standpoint (yes or no) can be persuaded to be a neutral agent, if its capacity of persuasion is lower than the average CP of its opponents. Besides that a neutral agent will change its state and follow a more persuasive opinion. Starting from two opposite opinions with different rates, repeated local discussions are found to drive the minority reversal. It reveals that in addition to the initial minority, the number of neutral agents is also an important factor to the eventual winners. During the process of consensus, there exists a threshold of initial fraction to guarantee one side win. The results have a guiding significance for designing strategies to win a public debate.

Attitudes to animal euthanasia do not correlate with acceptance of human euthanasia or suicide.

PubMed

Ogden, U; Kinnison, T; May, S A

2012-08-18

Several reasons have been suggested for the elevated risk of suicide experienced by those in the veterinary profession. The current study aimed to investigate possible links between veterinarians' attitudes to 'convenience' or non-justified animal euthanasia and attitudes towards human euthanasia and suicide. Veterinary students and graduates had a negative attitude towards convenience animal euthanasia, but their attitudes changed over time (pre-clinical studies, clinical studies and recently graduated). A greater tolerance to euthanasia was displayed in the later years of study and post qualification - primarily by males. Attitudes towards both human euthanasia and suicide, however, remained stable over time and indicated on average a neutral stance. No correlations were found between attitudes to convenience euthanasia and either human euthanasia or suicide, suggesting a tolerance to convenience euthanasia of animals does not lead to desensitisation in valuing human life and a changed attitude to human euthanasia or suicide, or vice versa. Attitudes to human euthanasia and suicide were predictably correlated, perhaps suggesting an overarching attitude towards control over human death. The results of the current study throw into question the argument that it is the changes in attitudes to animal life that affect veterinarian's attitudes to human life and contribute to the high suicide rate.

Object-based Encoding in Visual Working Memory: Evidence from Memory-driven Attentional Capture.

PubMed

Gao, Zaifeng; Yu, Shixian; Zhu, Chengfeng; Shui, Rende; Weng, Xuchu; Li, Peng; Shen, Mowei

2016-03-09

Visual working memory (VWM) adopts a specific manner of object-based encoding (OBE) to extract perceptual information: Whenever one feature-dimension is selected for entry into VWM, the others are also extracted. Currently most studies revealing OBE probed an 'irrelevant-change distracting effect', where changes of irrelevant-features dramatically affected the performance of the target feature. However, the existence of irrelevant-feature change may affect participants' processing manner, leading to a false-positive result. The current study conducted a strict examination of OBE in VWM, by probing whether irrelevant-features guided the deployment of attention in visual search. The participants memorized an object's colour yet ignored shape and concurrently performed a visual-search task. They searched for a target line among distractor lines, each embedded within a different object. One object in the search display could match the shape, colour, or both dimensions of the memory item, but this object never contained the target line. Relative to a neutral baseline, where there was no match between the memory and search displays, search time was significantly prolonged in all match conditions, regardless of whether the memory item was displayed for 100 or 1000 ms. These results suggest that task-irrelevant shape was extracted into VWM, supporting OBE in VWM.