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Sample records for channel antikaon-nucleon system

  1. SIDDHARTA results and implications of the results on antikaon-nucleon interaction

    NASA Astrophysics Data System (ADS)

    Marton, J.; Bazzi, M.; Beer, G.; Berucci, C.; Bellotti, G.; Bosnar, D.; Bragadireanu, A. M.; Cargnelli, M.; Clozza, A.; Curceanu, C.; Butt, A. Dawood; Fiorini, C.; Ghio, F.; Guaraldo, C.; Hayano, R.; Iliescu, M.; Iwasaki, M.; Sandri, P. Levi; Okada, S.; Pietreanu, D.; Piscicchia, K.; Vidal, A. Romero; Scordo, A.; Shi, H.; Sirghi, D. L.; Sirghi, F.; Tatsuno, H.; Doce, O. Vazquez; Widmann, E.; Zmeskal, J.

    2016-05-01

    The interaction of antikaons (K-) with nucleons and nuclei in the low-energy regime represents an active research field in hadron physics. There are important open questions like the existence of antikaon nuclear bound states like the prototype system being K- pp. Unique and rather direct experimental access to the antikaon-nucleon scattering lengths is provided by precision X-ray spectroscopy of transitions in low-lying states in light kaonic atoms like kaonic hydrogen and helium isotopes. In the SIDDHARTA experiment at the electron-positron collider DAΦNE of LNF-INFN we measured the most precise values of the strong interaction observables, i.e. the strong interaction on the 1s ground state of the electromagnetically bound K-p atom leading to energy shift and broadening of the 1s state. The SIDDHARTA result triggered new theoretical work, which achieved major progress in the understanding of the low-energy strong interaction with strangeness reflected by the antikaon-nucleon scattering lengths calculated with the K--proton amplitudes constrained by the SIDDHARTA data. The most important open question is the experimental determination of the hadronic energy shift and width of kaonic deuterium which is planned by the SIDDHARTA-2 Collaboration.

  2. A Cloudy Quark Bag Model of S, P, and D wave interactions for the coupled channel antikaon-nucleon system

    SciTech Connect

    He, Guangliang.

    1992-05-15

    The Cloudy Quark Bag Model is extended from S-wave to P- and D-wave. The parameters of the model are determined by K{sup {minus}}p scattering cross section data, K{sup {minus}}p {yields}{Sigma}{pi}{pi}{pi} production data, K{sup {minus}}p threshold branching ratio data, and K{sup {minus}}p {yields}{Lambda}{pi}{pi}{pi} production data. The resonance structure of the {Lambda}(1405), {Sigma}(1385), and {Lambda}(1520) are studied in the model. The shift and width of kaonic hydrogen are calculated using the model.

  3. Antikaon-nucleon interaction and Λ(1405) in chiral SU(3) dynamics

    NASA Astrophysics Data System (ADS)

    Kamiya, Yuki; Miyahara, Kenta; Ohnishi, Shota; Ikeda, Yoichi; Hyodo, Tetsuo; Oset, Eulogio; Weise, Wolfram

    2016-10-01

    The properties of the Λ (1405) resonance are key ingredients for determining the antikaon-nucleon interaction in strangeness nuclear physics, and the novel internal structure of the Λ (1405) is of great interest in hadron physics, as a prototype case of a baryon that does not fit into the simple three-quark picture. We show that a quantitative description of the antikaon-nucleon interaction with the Λ (1405) is achieved in the framework of chiral SU(3) dynamics, with the help of recent experimental progress. Further constraints on the K bar N subthreshold interaction are provided by analyzing πΣ spectra in various processes, such as the K- d → πΣn reaction and the Λc → ππΣ decay. The structure of the Λ (1405) is found to be dominated by an antikaon-nucleon molecular configuration, based on its wavefunction derived from a realistic K bar N potential and the compositeness criteria from a model-independent weak-binding relation.

  4. Lattice QCD evidence that the Λ(1405) resonance is an antikaon-nucleon molecule.

    PubMed

    Hall, Jonathan M M; Kamleh, Waseem; Leinweber, Derek B; Menadue, Benjamin J; Owen, Benjamin J; Thomas, Anthony W; Young, Ross D

    2015-04-01

    For almost 50 years the structure of the Λ(1405) resonance has been a mystery. Even though it contains a heavy strange quark and has odd parity, its mass is lower than any other excited spin-1/2 baryon. Dalitz and co-workers speculated that it might be a molecular state of an antikaon bound to a nucleon. However, a standard quark-model structure is also admissible. Although the intervening years have seen considerable effort, there has been no convincing resolution. Here we present a new lattice QCD simulation showing that the strange magnetic form factor of the Λ(1405) vanishes, signaling the formation of an antikaon-nucleon molecule. Together with a Hamiltonian effective-field-theory model analysis of the lattice QCD energy levels, this strongly suggests that the structure is dominated by a bound antikaon-nucleon component. This result clarifies that not all states occurring in nature can be described within a simple quark model framework and points to the existence of exotic molecular meson-nucleon bound states. PMID:25884122

  5. On the pole content of coupled channels chiral approaches used for the K bar N system

    NASA Astrophysics Data System (ADS)

    Cieplý, A.; Mai, M.; Meißner, Ulf-G.; Smejkal, J.

    2016-10-01

    Several theoretical groups describe the antikaon-nucleon interaction at low energies within approaches based on the chiral SU(3) dynamics and including next-to-leading order contributions. We present a comparative analysis of the pertinent models and discuss in detail their pole contents. It is demonstrated that the approaches lead to very different predictions for the K- p amplitude extrapolated to subthreshold energies as well as for the K- n amplitude. The origin of the poles generated by the models is traced to the so-called zero coupling limit, in which the inter-channel couplings are switched off. This provides new insights into the pole contents of the various approaches. In particular, different concepts of forming the Λ (1405) resonance are revealed and constraints related to the appearance of such poles in a given approach are discussed.

  6. Fluid channeling system

    NASA Technical Reports Server (NTRS)

    Davis, Donald Y. (Inventor); Hitch, Bradley D. (Inventor)

    1994-01-01

    A fluid channeling system includes a fluid ejector, a heat exchanger, and a fluid pump disposed in series flow communication The ejector includes a primary inlet for receiving a primary fluid, and a secondary inlet for receiving a secondary fluid which is mixed with the primary fluid and discharged therefrom as ejector discharge. Heat is removed from the ejector discharge in the heat exchanger, and the heat exchanger discharge is compressed in the fluid pump and channeled to the ejector secondary inlet as the secondary fluid In an exemplary embodiment, the temperature of the primary fluid is greater than the maximum operating temperature of a fluid motor powering the fluid pump using a portion of the ejector discharge, with the secondary fluid being mixed with the primary fluid so that the ejector discharge temperature is equal to about the maximum operating temperature of the fluid motor.

  7. A three channel telemetry system

    NASA Technical Reports Server (NTRS)

    Lesho, Jeffery C.; Eaton, Harry A. C.

    1993-01-01

    A three channel telemetry system intended for biomedical applications is described. The transmitter is implemented in a single chip using a 2 micron BiCMOS processes. The operation of the system and the test results from the latest chip are discussed. One channel is always dedicated to temperature measurement while the other two channels are generic. The generic channels carry information from transducers that are interfaced to the system through on-chip general purpose operational amplifiers. The generic channels have different bandwidths: one from dc to 250 Hz and the other from dc to 1300 Hz. Each generic channel modulates a current controlled oscillator to produce a frequency modulated signal. The two frequency modulated signals are summed and used to amplitude modulate the temperature signal which acts as a carrier. A near-field inductive link telemeters the combined signals over a short distance. The chip operates on a supply voltage anywhere from 2.5 to 3.6 Volts and draws less than 1 mA when transmitting a signal. The chip can be incorporated into ingestible, implantable and other configurations. The device can free the patient from tethered data collection systems and reduces the possibility of infection from subcutaneous leads. Data telemetry can increase patient comfort leading to a greater acceptance of monitoring.

  8. Multiple channel data acquisition system

    DOEpatents

    Crawley, H. Bert; Rosenberg, Eli I.; Meyer, W. Thomas; Gorbics, Mark S.; Thomas, William D.; McKay, Roy L.; Homer, Jr., John F.

    1990-05-22

    A multiple channel data acquisition system for the transfer of large amounts of data from a multiplicity of data channels has a plurality of modules which operate in parallel to convert analog signals to digital data and transfer that data to a communications host via a FASTBUS. Each module has a plurality of submodules which include a front end buffer (FEB) connected to input circuitry having an analog to digital converter with cache memory for each of a plurality of channels. The submodules are interfaced with the FASTBUS via a FASTBUS coupler which controls a module bus and a module memory. The system is triggered to effect rapid parallel data samplings which are stored to the cache memories. The cache memories are uploaded to the FEBs during which zero suppression occurs. The data in the FEBs is reformatted and compressed by a local processor during transfer to the module memory. The FASTBUS coupler is used by the communications host to upload the compressed and formatted data from the module memory. The local processor executes programs which are downloaded to the module memory through the FASTBUS coupler.

  9. Multiple channel data acquisition system

    DOEpatents

    Crawley, H.B.; Rosenberg, E.I.; Meyer, W.T.; Gorbics, M.S.; Thomas, W.D.; McKay, R.L.; Homer, J.F. Jr.

    1990-05-22

    A multiple channel data acquisition system for the transfer of large amounts of data from a multiplicity of data channels has a plurality of modules which operate in parallel to convert analog signals to digital data and transfer that data to a communications host via a FASTBUS. Each module has a plurality of submodules which include a front end buffer (FEB) connected to input circuitry having an analog to digital converter with cache memory for each of a plurality of channels. The submodules are interfaced with the FASTBUS via a FASTBUS coupler which controls a module bus and a module memory. The system is triggered to effect rapid parallel data samplings which are stored to the cache memories. The cache memories are uploaded to the FEBs during which zero suppression occurs. The data in the FEBs is reformatted and compressed by a local processor during transfer to the module memory. The FASTBUS coupler is used by the communications host to upload the compressed and formatted data from the module memory. The local processor executes programs which are downloaded to the module memory through the FASTBUS coupler. 25 figs.

  10. KATP Channels in the Cardiovascular System.

    PubMed

    Foster, Monique N; Coetzee, William A

    2016-01-01

    KATP channels are integral to the functions of many cells and tissues. The use of electrophysiological methods has allowed for a detailed characterization of KATP channels in terms of their biophysical properties, nucleotide sensitivities, and modification by pharmacological compounds. However, even though they were first described almost 25 years ago (Noma 1983, Trube and Hescheler 1984), the physiological and pathophysiological roles of these channels, and their regulation by complex biological systems, are only now emerging for many tissues. Even in tissues where their roles have been best defined, there are still many unanswered questions. This review aims to summarize the properties, molecular composition, and pharmacology of KATP channels in various cardiovascular components (atria, specialized conduction system, ventricles, smooth muscle, endothelium, and mitochondria). We will summarize the lessons learned from available genetic mouse models and address the known roles of KATP channels in cardiovascular pathologies and how genetic variation in KATP channel genes contribute to human disease.

  11. Channel drop filter for CWDM systems

    NASA Astrophysics Data System (ADS)

    Youcef Mahmoud, Mahmoud; Bassou, Ghaouti; de Fornel, Frédérique; Taalbi, Ahmed

    2013-10-01

    In this paper, a new design of channel drop filter (CDF) based on two-dimensional photonic crystal ring resonators (PCRRs) is provided by two-dimensional (2D) finite-difference time-domain (FDTD) simulations in triangular lattice photonic crystal (PC) silicon rods. 100% forward dropping efficiency and a quality factor of over 1000 can be achieved at maximum transfer efficiency while the operating wavelength is 1550 nm. Through this novel component, three channel drop operation with 100% dropping efficiencies at all output channels can be obtained. The proposed filter provides a possibility of channel drop filter and could be used in coarse wavelength division multiplexing (CWDM) systems.

  12. Multi-channel gas-delivery system

    DOEpatents

    Rozenzon, Yan; Trujillo, Robert T.; Beese, Steven C.

    2016-09-13

    One embodiment of the present invention provides a gas-delivery system for delivering reaction gas to a reactor chamber. The gas-delivery system includes a main gas-inlet port for receiving reaction gases and a gas-delivery plate that includes a plurality of gas channels. A gas channel includes a plurality of gas holes for allowing the reaction gases to enter the reactor chamber from the gas channel. The gas-delivery system further includes a plurality of sub-gas lines coupling together the main gas-inlet port and the gas-delivery plate, and a respective sub-gas line is configured to deliver a portion of the received reaction gases to a corresponding gas channel.

  13. Three-body calculations for the K - pp system within potential models

    NASA Astrophysics Data System (ADS)

    Kezerashvili, R. Ya; Tsiklauri, S. M.; Filikhin, I.; Suslov, V. M.; Vlahovic, B.

    2016-06-01

    We present three-body nonrelativistic calculations within the framework of a potential model for the kaonic cluster K - pp using two methods: the method of hyperspherical harmonics in the momentum representation and the method of Faddeev equations in configuration space. To perform numerical calculations, different NN and antikaon-nucleon interactions are applied. The results of the calculations for the ground-state energy for the K - pp system obtained by both methods are in reasonable agreement. Although the ground-state energy is not sensitive to the pp interaction, it shows very strong dependence on the K - p potential. We show that the dominant clustering of the {K}-{pp} system in the configuration Λ (1405) + p allows us to calculate the binding energy to good accuracy within a simple cluster approach for the differential Faddeev equations. The theoretical discrepancies in the binding energy and width for the K - pp system related to the different pp and K - p interactions are addressed.

  14. A multi-channel waveform digitizer system

    SciTech Connect

    Bieser, F.; Muller, W.F.J. )

    1990-04-01

    The authors report on the design and performance of a multichannel waveform digitizer system for use with the Multiple Sample Ionization Chamber (MUSIC) Detector at the Bevalac. 128 channels of 20 MHz Flash ADC plus 256 word deep memory are housed in a single crate. Digital thresholds and hit pattern logic facilitate zero suppression during readout which is performed over a standard VME bus.

  15. [Synopsis about the hypothesis of "information channel" of channel-collateral system].

    PubMed

    Chang, Xi-Lang

    2008-10-01

    The author of the present paper founded a theorem about the "incompleteness of single channel structure" (nerve, blood vessel, lymphatic, interspace, aperture, etc.) through quantitative and qualitative analysis about the economic information channel in the human body, which eliminates the probability of single channel structure in the information channel of channel (meridian)-collateral system. After comprehensive analysis on the current researches, the author puts forward a neodoxy, i.e., the body "information channel" structure of the channel-collateral system, mainly follows the distribution regularity of systemic statistics, and is not a single specific entity; various layers of the information channel in the main stems of the channel-collaterals are composed of optimized structure tissues. Hence, the structure of this information channel of channel-collateral system is an overall-optimized, sequential and compatible systemic structure. From this neodoxy, the author brings forward a working principle of channel-collaterals, which is supported theoretically by bio-auxology. The longitudinal distribution of the main stems of meridian-collaterals is considered to result from that in the process of the animal evolution, in the animals moving forward, the microscopic complicated movement of intracorporeal information and energy molecules is related to the forward macroscopic and non-uniform movement of organism in trans-measure. Its impulse and kinetic momentum forms a main vector in the longitudinal direction of the body (the direction of the main stem of channel-collaterals). In order to adapt to and utilize natural regularities, the main stems of the channel-collaterals gradually differentiate and evolve in the living organism, forming a whole system. The "hypothesis of biological origin of channel-collateral system" and "that of information channel of the channel-collaterals in the body" constitute a relatively complete theoretical system framework.

  16. Single-channel prototype terahertz endoscopic system

    NASA Astrophysics Data System (ADS)

    Doradla, Pallavi; Alavi, Karim; Joseph, Cecil; Giles, Robert

    2014-08-01

    We demonstrate the design and development of an innovative single-channel terahertz (THz) prototype endoscopic imaging system based on flexible metal-coated THz waveguides and a polarization specific detection technique. The continuous-wave (CW) THz imaging system utilizes a single channel to transmit and collect the reflected intrinsic THz signal from the sample. Since the prototype system relies on a flexible waveguide assembly that is small enough in diameter, it can be readily integrated with a conventional optical endoscope. This study aims to show the feasibility of waveguide enabled THz imaging. We image various objects in transmission and reflection modes. We also image normal and cancerous colonic tissues in reflectance mode using a polarization specific imaging technique. The resulting cross-polarized THz reflectance images showed contrast between normal and cancerous colonic tissues at 584 GHz. The level of contrast observed using endoscopic imaging correlates well with contrast levels observed in ex vivo THz reflectance studies of colon cancer. This indicates that the single-channel flexible waveguide-based THz endoscope presented here represents a significant step forward in clinical endoscopic application of THz technology to aid in in vivo cancer screening.

  17. Multi-channel medical imaging system

    DOEpatents

    Frangioni, John V.

    2016-05-03

    A medical imaging system provides simultaneous rendering of visible light and fluorescent images. The system may employ dyes in a small-molecule form that remain in a subject's blood stream for several minutes, allowing real-time imaging of the subject's circulatory system superimposed upon a conventional, visible light image of the subject. The system may provide an excitation light source to excite the fluorescent substance and a visible light source for general illumination within the same optical guide used to capture images. The system may be configured for use in open surgical procedures by providing an operating area that is closed to ambient light. The systems described herein provide two or more diagnostic imaging channels for capture of multiple, concurrent diagnostic images and may be used where a visible light image may be usefully supplemented by two or more images that are independently marked for functional interest.

  18. Multi-channel medical imaging system

    SciTech Connect

    Frangioni, John V

    2013-12-31

    A medical imaging system provides simultaneous rendering of visible light and fluorescent images. The system may employ dyes in a small-molecule form that remain in the subject's blood stream for several minutes, allowing real-time imaging of the subject's circulatory system superimposed upon a conventional, visible light image of the subject. The system may provide an excitation light source to excite the fluorescent substance and a visible light source for general illumination within the same optical guide used to capture images. The system may be configured for use in open surgical procedures by providing an operating area that is closed to ambient light. The systems described herein provide two or more diagnostic imaging channels for capture of multiple, concurrent diagnostic images and may be used where a visible light image may be usefully supplemented by two or more images that are independently marked for functional interest.

  19. 16. VIEW NORTH FROM SWINGSPAN DECK, CHANNEL OPEN, FENDER SYSTEM ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    16. VIEW NORTH FROM SWING-SPAN DECK, CHANNEL OPEN, FENDER SYSTEM AND ABUTMENT ON CHANNEL END OF NORTHERN FIXED SPAN; new bridge located on right - Tipers Bridge, Spanning Great Wicomico River at State Route 200, Kilmarnock, Lancaster County, VA

  20. The Discovery Channel Telescope optical coating system

    NASA Astrophysics Data System (ADS)

    Marshall, Heather K.; Ash, Gary S.; Parsley, William F.

    2010-07-01

    The Discovery Channel Telescope (DCT) is a project of Lowell Observatory, undertaken with support from Discovery Communications, Inc., to design and construct a 4-meter class telescope and support facility on a site approximately 40 miles southeast of Flagstaff, AZ. Lowell Observatory contracted with Dynavac of Hingham, MA to design and build an optical coating system for the DCT optics. The DCT Optical Coating System includes a mechanical roughing pump, two high-vacuum cryogenic pumps, a Meissner trap, evaporative filament aluminum deposition system, LabView software and PLC-based control system, and all ancillary support equipment. The system was installed at the site and acceptance testing was completed in October 2009. The Optical Coating System achieved near perfect reflectivity performance, thickness uniformity of 1000 angstroms +/-10%, and adhesion conforming to MIL-F-48616, Section 4.6.8.1. This paper discusses the design and analysis of the coating system, the process of transportation and assembly as well as testing results.

  1. Multiple channel optical data acquisition system

    DOEpatents

    Fasching, G.E.; Goff, D.R.

    1985-02-22

    A multiple channel optical data acquisition system is provided in which a plurality of remote sensors monitoring specific process variable are interrogated by means of a single optical fiber connecting the remote station/sensors to a base station. The remote station/sensors derive all power from light transmitted through the fiber from the base station. Each station/sensor is individually accessed by means of a light modulated address code sent over the fiber. The remote station/sensors use a single light emitting diode to both send and receive light signals to communicate with the base station and provide power for the remote station. The system described can power at least 100 remote station/sensors over an optical fiber one mile in length.

  2. Channel coding in the space station data system network

    NASA Technical Reports Server (NTRS)

    Healy, T.

    1982-01-01

    A detailed discussion of the use of channel coding for error correction, privacy/secrecy, channel separation, and synchronization is presented. Channel coding, in one form or another, is an established and common element in data systems. No analysis and design of a major new system would fail to consider ways in which channel coding could make the system more effective. The presence of channel coding on TDRS, Shuttle, the Advanced Communication Technology Satellite Program system, the JSC-proposed Space Operations Center, and the proposed 30/20 GHz Satellite Communication System strongly support the requirement for the utilization of coding for the communications channel. The designers of the space station data system have to consider the use of channel coding.

  3. Channel capacities of an exactly solvable spin-star system

    NASA Astrophysics Data System (ADS)

    Arshed, Nigum; Toor, A. H.; Lidar, Daniel A.

    2010-06-01

    We calculate the entanglement-assisted and -unassisted channel capacities of an exactly solvable spin star system, which models the quantum dephasing channel. The capacities for this non-Markovian model exhibit a strong dependence on the coupling strengths of the bath spins with the system, the bath temperature, and the number of bath spins. For equal couplings and bath frequencies, the channel becomes periodically noiseless.

  4. Channel capacities of an exactly solvable spin-star system

    SciTech Connect

    Arshed, Nigum; Toor, A. H.; Lidar, Daniel A.

    2010-06-15

    We calculate the entanglement-assisted and -unassisted channel capacities of an exactly solvable spin star system, which models the quantum dephasing channel. The capacities for this non-Markovian model exhibit a strong dependence on the coupling strengths of the bath spins with the system, the bath temperature, and the number of bath spins. For equal couplings and bath frequencies, the channel becomes periodically noiseless.

  5. BK Channels in the Vascular System.

    PubMed

    Krishnamoorthy-Natarajan, G; Koide, M

    2016-01-01

    Autoregulation of blood flow is essential for the preservation of organ function to ensure continuous supply of oxygen and essential nutrients and removal of metabolic waste. This is achieved by controlling the diameter of muscular arteries and arterioles that exhibit a myogenic response to changes in arterial blood pressure, nerve activity and tissue metabolism. Large-conductance voltage and Ca(2+)-dependent K(+) channels (BK channels), expressed exclusively in smooth muscle cells (SMCs) in the vascular wall of healthy arteries, play a critical role in regulating the myogenic response. Activation of BK channels by intracellular, local, and transient ryanodine receptor-mediated "Ca(2+) sparks," provides a hyperpolarizing influence on the SMC membrane potential thereby decreasing the activity of voltage-dependent Ca(2+) channels and limiting Ca(2+) influx to promote SMC relaxation and vasodilation. The BK channel α subunit, a large tetrameric protein with each monomer consisting of seven-transmembrane domains, a long intracellular C-terminal tail and an extracellular N-terminus, associates with the β1 and γ subunits in vascular SMCs. The BK channel is regulated by factors originating within the SMC or from the endothelium, perivascular nerves and circulating blood, that significantly alter channel gating properties, Ca(2+) sensitivity and expression of the α and/or β1 subunit. The BK channel thus serves as a central receiving dock that relays the effects of the changes in several such concomitant autocrine and paracrine factors and influences cardiovascular health. This chapter describes the primary mechanism of regulation of myogenic response by BK channels and the alterations to this mechanism wrought by different vasoactive mediators. PMID:27238270

  6. Role of TRP channels in the cardiovascular system.

    PubMed

    Yue, Zhichao; Xie, Jia; Yu, Albert S; Stock, Jonathan; Du, Jianyang; Yue, Lixia

    2015-02-01

    The transient receptor potential (TRP) superfamily consists of a large number of nonselective cation channels with variable degree of Ca(2+)-permeability. The 28 mammalian TRP channel proteins can be grouped into six subfamilies: canonical, vanilloid, melastatin, ankyrin, polycystic, and mucolipin TRPs. The majority of these TRP channels are expressed in different cell types including both excitable and nonexcitable cells of the cardiovascular system. Unlike voltage-gated ion channels, TRP channels do not have a typical voltage sensor, but instead can sense a variety of other stimuli including pressure, shear stress, mechanical stretch, oxidative stress, lipid environment alterations, hypertrophic signals, and inflammation products. By integrating multiple stimuli and transducing their activity to downstream cellular signal pathways via Ca(2+) entry and/or membrane depolarization, TRP channels play an essential role in regulating fundamental cell functions such as contraction, relaxation, proliferation, differentiation, and cell death. With the use of targeted deletion and transgenic mouse models, recent studies have revealed that TRP channels are involved in numerous cellular functions and play an important role in the pathophysiology of many diseases in the cardiovascular system. Moreover, several TRP channels are involved in inherited diseases of the cardiovascular system. This review presents an overview of current knowledge concerning the physiological functions of TRP channels in the cardiovascular system and their contributions to cardiovascular diseases. Ultimately, TRP channels may become potential therapeutic targets for cardiovascular diseases.

  7. Role of TRP channels in the cardiovascular system

    PubMed Central

    Yue, Zhichao; Xie, Jia; Yu, Albert S.; Stock, Jonathan; Du, Jianyang

    2014-01-01

    The transient receptor potential (TRP) superfamily consists of a large number of nonselective cation channels with variable degree of Ca2+-permeability. The 28 mammalian TRP channel proteins can be grouped into six subfamilies: canonical, vanilloid, melastatin, ankyrin, polycystic, and mucolipin TRPs. The majority of these TRP channels are expressed in different cell types including both excitable and nonexcitable cells of the cardiovascular system. Unlike voltage-gated ion channels, TRP channels do not have a typical voltage sensor, but instead can sense a variety of other stimuli including pressure, shear stress, mechanical stretch, oxidative stress, lipid environment alterations, hypertrophic signals, and inflammation products. By integrating multiple stimuli and transducing their activity to downstream cellular signal pathways via Ca2+ entry and/or membrane depolarization, TRP channels play an essential role in regulating fundamental cell functions such as contraction, relaxation, proliferation, differentiation, and cell death. With the use of targeted deletion and transgenic mouse models, recent studies have revealed that TRP channels are involved in numerous cellular functions and play an important role in the pathophysiology of many diseases in the cardiovascular system. Moreover, several TRP channels are involved in inherited diseases of the cardiovascular system. This review presents an overview of current knowledge concerning the physiological functions of TRP channels in the cardiovascular system and their contributions to cardiovascular diseases. Ultimately, TRP channels may become potential therapeutic targets for cardiovascular diseases. PMID:25416190

  8. Ion Channels as Drug Targets in Central Nervous System Disorders

    PubMed Central

    Waszkielewicz, A.M; Gunia, A; Szkaradek, N; Słoczyńska, K; Krupińska, S; Marona, H

    2013-01-01

    Ion channel targeted drugs have always been related with either the central nervous system (CNS), the peripheral nervous system, or the cardiovascular system. Within the CNS, basic indications of drugs are: sleep disorders, anxiety, epilepsy, pain, etc. However, traditional channel blockers have multiple adverse events, mainly due to low specificity of mechanism of action. Lately, novel ion channel subtypes have been discovered, which gives premises to drug discovery process led towards specific channel subtypes. An example is Na+ channels, whose subtypes 1.3 and 1.7-1.9 are responsible for pain, and 1.1 and 1.2 – for epilepsy. Moreover, new drug candidates have been recognized. This review is focusing on ion channels subtypes, which play a significant role in current drug discovery and development process. The knowledge on channel subtypes has developed rapidly, giving new nomenclatures of ion channels. For example, Ca2+ channels are not any more divided to T, L, N, P/Q, and R, but they are described as Cav1.1-Cav3.3, with even newer nomenclature α1A-α1I and α1S. Moreover, new channels such as P2X1-P2X7, as well as TRPA1-TRPV1 have been discovered, giving premises for new types of analgesic drugs. PMID:23409712

  9. Channel

    NASA Technical Reports Server (NTRS)

    2006-01-01

    [figure removed for brevity, see original site] Context image for PIA03693 Channel

    This channel is located south of Iani Chaos.

    Image information: VIS instrument. Latitude -10.9N, Longitude 345.5E. 17 meter/pixel resolution.

    Note: this THEMIS visual image has not been radiometrically nor geometrically calibrated for this preliminary release. An empirical correction has been performed to remove instrumental effects. A linear shift has been applied in the cross-track and down-track direction to approximate spacecraft and planetary motion. Fully calibrated and geometrically projected images will be released through the Planetary Data System in accordance with Project policies at a later time.

    NASA's Jet Propulsion Laboratory manages the 2001 Mars Odyssey mission for NASA's Office of Space Science, Washington, D.C. The Thermal Emission Imaging System (THEMIS) was developed by Arizona State University, Tempe, in collaboration with Raytheon Santa Barbara Remote Sensing. The THEMIS investigation is led by Dr. Philip Christensen at Arizona State University. Lockheed Martin Astronautics, Denver, is the prime contractor for the Odyssey project, and developed and built the orbiter. Mission operations are conducted jointly from Lockheed Martin and from JPL, a division of the California Institute of Technology in Pasadena.

  10. The new secondary channel control system at TRIUMF

    NASA Astrophysics Data System (ADS)

    Keitel, R.; Bishop, D.; Dale, D.; England, N.; Harrison, D.

    1990-08-01

    The control of the secondary channels at TRIUMF has been decentralized. Each channel is now controlled through a single CAMAC crate from an IBM PC in the experimental counting room. Intelligent motor controllers were developed to replace the ageing slit control system. Advanced features of the control software package TICS, such as computer optimization of channel parameters and high-voltage conditioning of the de separators, are described.

  11. Energy, time, and channel evolution in catastrophically disturbed fluvial systems

    USGS Publications Warehouse

    Simon, A.

    1992-01-01

    Specific energy is shown to decrease nonlinearly with time during channel evolution and provides a measure of reductions in available energy at the channel bed. Data from two sites show convergence towards a minimum specific energy with time. Time-dependent reductions in specific energy at a point act in concert with minimization of the rate of energy dissipation over a reach during channel evolution as the fluvial systems adjust to a new equilibrium.

  12. TRPM4 channels in the cardiovascular system.

    PubMed

    Kruse, Martin; Pongs, Olaf

    2014-04-01

    The non-selective Transient Receptor Potential Melastatin 4 (TRPM4) cation channel is abundantly expressed in cardiac cells, being involved in several aspects of cardiac rhythmicity, including cardiac conduction, pace making and action-potential repolarization. Dominantly inherited mutations in the TRPM4 gene are associated with the cardiac bundle-branch disorder progressive familial heart block type I (PFHBI) and isolated cardiac conduction disease (ICCD) giving rise to atrio-ventricular conduction block (AVB), right bundle branch block, bradycardia, and the Brugada syndrome. The mutant phenotypes closely resemble those associated with mutations in the SCN5A gene, encoding the voltage-gated Na(+) channel NaV1.5. These observations and the unexpected partnership with sulfonylurea-receptors (SURs) makes the TRPM4 channel a promising novel target for treatment of cardiac disorders.

  13. TRP channels in the digestive system

    PubMed Central

    Holzer, Peter

    2011-01-01

    Several of the 28 mammalian transient receptor potential (TRP) channel subunits are expressed throughout the alimentary canal where they play important roles in taste, chemo- and mechanosensation, thermoregulation, pain and hyperalgesia, mucosal function and homeostasis, control of motility by neurons, interstitial cells of Cajal and muscle cells, and vascular function. While the implications of some TRP channels, notably TRPA1, TRPC4, TRPM5, TRPM6, TRPM7, TRPV1, TRPV4, and TRPV6, have been investigated in much detail, the understanding of other TRP channels in their relevance to digestive function lags behind. The polymodal chemo- and mechanosensory function of TRPA1, TRPM5, TRPV1 and TRPV4 is particularly relevant to the alimentary canal whose digestive and absorptive function depends on the surveillance and integration of many chemical and physical stimuli. TRPV5 and TRPV6 as well as TRPM6 and TRPM7 appear to be essential for the absorption of Ca2+ and Mg2+, respectively, while TRPM7 appears to contribute to the pacemaker activity of the interstitial cells of Cajal, and TRPC4 transduces smooth muscle contraction evoked by muscarinic acetylcholine receptor activation. The implication of some TRP channels in pathological processes has raised enormous interest in exploiting them as a therapeutic target. This is particularly true for TRPV1, TRPV4 and TRPA1, which may be targeted for the treatment of several conditions of chronic abdominal pain. Consequently, blockers of these TRP channels have been developed, and their clinical usefulness has yet to be established. PMID:20932260

  14. Visualization Techniques for Single Channel DPF Systems

    SciTech Connect

    Dillon, Heather E.; Maupin, Gary D.; Carlson, Shelley J.; Saenz, Natalio T.; Gallant, Thomas R.

    2007-04-01

    New techniques have been developed to visualize soot deposition in both traditional and new diesel particulate filter (DPF) substrate materials using a modified cyanoacrylate fuming technique. Loading experiments have been conducted on a variety of single channel DPF substrates to develop a deeper understanding of soot penetration, soot deposition characteristics, and to confirm modeling results. Early results indicate that stabilizing the soot layer using a vapor adhesive may allow analysis of the layer with new methods.

  15. TRPV4 channels: physiological and pathological role in cardiovascular system.

    PubMed

    Randhawa, Puneet Kaur; Jaggi, Amteshwar Singh

    2015-11-01

    TRPV4 channels are non-selective cation channels permeable to Ca(2+), Na(+), and Mg(2+) ions. Recently, TRPV4 channels have received considerable attention as these channels are widely expressed in the cardiovascular system including endothelial cells, cardiac fibroblasts, vascular smooth muscles, and peri-vascular nerves. Therefore, these channels possibly play a pivotal role in the maintenance of cardiovascular homeostasis. TRPV4 channels critically regulate flow-induced arteriogenesis, TGF-β1-induced differentiation of cardiac fibroblasts into myofibroblasts, and heart failure-induced pulmonary edema. These channels also mediate hypoxia-induced increase in proliferation and migration of pulmonary artery smooth muscle cells and progression of pulmonary hypertension. These channels also maintain flow-induced vasodilation and preserve vascular function by directly activating Ca(2+)-dependent KCa channels. Furthermore, these may also induce vasodilation and maintain blood pressure indirectly by evoking the release of NO, CGRP, and substance P. The present review discusses the evidences and the potential mechanisms implicated in diverse responses including arteriogenesis, cardiac remodeling, congestive heart failure-induced pulmonary edema, pulmonary hypertension, flow-induced dilation, regulation of blood pressure, and hypoxic preconditioning.

  16. Design and performance of the LANL 158-channel magnetoencephalography system

    SciTech Connect

    Matlachov, A. N.; Kraus, Robert H., Jr.; Espy, M. A.; Best, E. D.; Briles, M. Carolyn; Raby, E. Y.; Flynn, E. R.

    2002-01-01

    Design and performance for a recently completed whole-head magnetoencephalography (MEG) system using a superconducting imaging-surface (SIS) surrounding an array of SQUID magnetometers is reported. The helmet-like SIS is hemispherical in shape with a brim. The SIS images nearby sources while shields sensors from ambient magnetic noise. The shielding factor depends on magnetometer position and orientation. Typical shielding values of 200 in central sulcus area have been observed. Nine reference channels form three vector magnetometers, which are placed outside SIS. Signal channels consist of 149 SQUID magnetometers with 0.84nT/{Phi}{sub 0} field sensitivity and less then 3 fT/{radical}Hz noise. Typical SQUID - room temperature separations are about 20mm in the cooled state. Twelve 16-channel flux-lock loop units are connected to two 96-channel control units allowing up to 192 total SQUID channels. The control unit includes signal conditioning circuits as well as system test and control circuits. After conditioning all signals are fed to 192-channel, 24-bit data acquisition system capable of sampling up to 48kSa/sec/channel. The SIS-MEG system enables high-quality human functional brain data to be recorded in a one-layer magnetically shielded room.

  17. Three-channel telemetry system with optical interface

    NASA Astrophysics Data System (ADS)

    Lesho, Jeffrey C.; Eaton, Harry A.

    1994-10-01

    An optical interface was incorporated into a three channel telemetry device to allow for communication to a packaged telemeter. Information transmitted on the optical link includes calibration parameters and commands to program the operation of the telemeter. The optical ink allows calibration information to be programmed into a telemeter, without the need for a bio-compatible electrical connection. The optical link was designed to completely reside on an integrated circuit chip. One of the three channels of the telemeter is dedicated to temperature measurement, while the other two channels are generic. The generic channels carry information from transducers that are interfaced to the system through on-chip general purpose operational amplifiers. The calibration information that is programmed into the telemeter is retrieved by time division multiplexing it with one of the generic channels.

  18. Note: optical receiver system for 152-channel magnetoencephalography.

    PubMed

    Kim, Jin-Mok; Kwon, Hyukchan; Yu, Kwon-kyu; Lee, Yong-Ho; Kim, Kiwoong

    2014-11-01

    An optical receiver system composing 13 serial data restore/synchronizer modules and a single module combiner converted optical 32-bit serial data into 32-bit synchronous parallel data for a computer to acquire 152-channel magnetoencephalography (MEG) signals. A serial data restore/synchronizer module identified 32-bit channel-voltage bits from 48-bit streaming serial data, and then consecutively reproduced 13 times of 32-bit serial data, acting in a synchronous clock. After selecting a single among 13 reproduced data in each module, a module combiner converted it into 32-bit parallel data, which were carried to 32-port digital input board in a computer. When the receiver system together with optical transmitters were applied to 152-channel superconducting quantum interference device sensors, this MEG system maintained a field noise level of 3 fT/√Hz @ 100 Hz at a sample rate of 1 kSample/s per channel.

  19. Note: Optical receiver system for 152-channel magnetoencephalography

    SciTech Connect

    Kim, Jin-Mok; Kwon, Hyukchan; Yu, Kwon-kyu; Lee, Yong-Ho; Kim, Kiwoong

    2014-11-15

    An optical receiver system composing 13 serial data restore/synchronizer modules and a single module combiner converted optical 32-bit serial data into 32-bit synchronous parallel data for a computer to acquire 152-channel magnetoencephalography (MEG) signals. A serial data restore/synchronizer module identified 32-bit channel-voltage bits from 48-bit streaming serial data, and then consecutively reproduced 13 times of 32-bit serial data, acting in a synchronous clock. After selecting a single among 13 reproduced data in each module, a module combiner converted it into 32-bit parallel data, which were carried to 32-port digital input board in a computer. When the receiver system together with optical transmitters were applied to 152-channel superconducting quantum interference device sensors, this MEG system maintained a field noise level of 3 fT/√Hz @ 100 Hz at a sample rate of 1 kSample/s per channel.

  20. Note: Optical receiver system for 152-channel magnetoencephalography

    NASA Astrophysics Data System (ADS)

    Kim, Jin-Mok; Kwon, Hyukchan; Yu, Kwon-kyu; Lee, Yong-Ho; Kim, Kiwoong

    2014-11-01

    An optical receiver system composing 13 serial data restore/synchronizer modules and a single module combiner converted optical 32-bit serial data into 32-bit synchronous parallel data for a computer to acquire 152-channel magnetoencephalography (MEG) signals. A serial data restore/synchronizer module identified 32-bit channel-voltage bits from 48-bit streaming serial data, and then consecutively reproduced 13 times of 32-bit serial data, acting in a synchronous clock. After selecting a single among 13 reproduced data in each module, a module combiner converted it into 32-bit parallel data, which were carried to 32-port digital input board in a computer. When the receiver system together with optical transmitters were applied to 152-channel superconducting quantum interference device sensors, this MEG system maintained a field noise level of 3 fT/√Hz @ 100 Hz at a sample rate of 1 kSample/s per channel.

  1. Evidence for nonlinear capacitance in biomembrane channel system.

    PubMed

    Ghosh, S; Bera, A K; Das, S

    1999-10-01

    The electrophysiological properties of voltage-dependent anion channels from mitochondrial membrane have been studied in a bilayer membrane system. It was observed that the probability of opening of the membrane channel depends on externally applied voltage and the plot is a bell-shaped curve symmetric around probability axis. A scheme of conformational energy levels under varying externally applied voltage was formulated. Assuming that the probability follows Boltzmann distribution, we arrive at an expression of change in energy containing a separate term identical to the energy of a capacitor. This fact indicates the possibility of existence of an added capacitance due to the channel protein. Further it was shown that the aforesaid channel capacitor could be a function of voltage leading to nonlinearity. We have offered a general method of calculating nonlinear capacitance from the experimental data on opening probability of a membrane channel. In case of voltage-dependent anion channel the voltage dependence of the capacitor has a power 0.786. The results have been interpreted in view of the structural organization of the channel protein in the membrane. Our hypothesis is that the phenomenon of capacitor behaviour is a general one for membrane channels.

  2. Pre-experiment testing of the Multi Channel Systems 16-channel preamplifier CPA16

    SciTech Connect

    Patin, J B; Stoyer, M A; Moody, K J; Friensehner, A V

    2003-11-03

    The 16-channel preamplifier model CPA16 from Multi Channel Systems was studied. The CPA16 preamplifier/amplifier module is a candidate to be used as the preamplifiers and amplifiers for the focal plane detectors of the Mass Analyzer of Super Heavy Atoms (MASHA). The equipment used to test the CPA16, the results of testing the CPA16 with a pulser, a mixed {sup 229}Th/{sup 148}Gd source and a {sup 252}Cf source, and a summary of the results will be presented.

  3. Multiple-channel Streaming Delivery for Omnidirectional Vision System

    NASA Astrophysics Data System (ADS)

    Iwai, Yoshio; Nagahara, Hajime; Yachida, Masahiko

    An omnidirectional vision is an imaging system that can capture a surrounding image in whole direction by using a hyperbolic mirror and a conventional CCD camera. This paper proposes a streaming server that can efficiently transfer movies captured by an omnidirectional vision system through the Internet. The proposed system uses multiple channels to deliver multiple movies synchronously. Through this method, the system enables clients to view the different direction of omnidirectional movies and also support the function to change the view are during playback period. Our evaluation experiments show that our proposed streaming server can effectively deliver multiple movies via multiple channels.

  4. A 1152 channel timing system for an electromagnetic calorimeter readout

    NASA Astrophysics Data System (ADS)

    Bonesini, M.; Bonvin, E.; Booth, P. S. L.; Carroll, L. J.; Cass, A. J.; Cavalli, D.; Cecchet, G.; Costa, G.; Donnat, M.; Dorsaz, P. A.; Edwards, D. N.; Fischer, J. R.; Fluri, L.; Frame, D.; Gianotti, F.; Jack, S.; Jackson, J. N.; Kelly, M.; Kienzle-Focacci, M. N.; Lucock, R.; Lynch, J. G.; Mandelli, L.; Martin, M.; Mathys, L.; Maxwell, A.; Mazzanti, M.; Myerscough, J. J.; Negus, P. J.; Pensotti-Rancoita, S.; Perini, L.; Perrin, D.; Range, W. H.; Rosselet, L.; Rutschmann, J.; Snow, S. W.; Tamborini, M.; Thompson, A. S.; Turnbull, R. M.; Wells, J.; Werlen, M.

    1988-01-01

    A 1152 channel timing system used with a large electromagnetic calorimeter is described. Analysis of the timing information from the vertical and horizontal elements of the calorimeter yielded values for the position coordinates of the showers. This information was used to resolve ambiguities in the pattern recognition arising from multiple showers. A resolution of better than 0.25 ns for all channels was achieved. The calibration methods employed to maintain this resolution over several years are discussed.

  5. Rearing channel catfish in a bioflac production system

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Production of channel catfish in an intensively managed mixed suspended-growth, or biofloc, production system was investigated in two studies. Management of unassimilated feed nitrogen is important as feeding rate is increased in intensified production systems. In a mixed suspended-growth production...

  6. Channel simulation for direct-detection optical communication systems

    NASA Technical Reports Server (NTRS)

    Tycz, M.; Fitzmaurice, M. W.

    1974-01-01

    A technique is described for simulating the random modulation imposed by atmospheric scintillation and transmitter pointing jitter on a direct-detection optical communication system. The system is capable of providing signal fading statistics which obey log-normal, beta, Rayleigh, Ricean, or chi-square density functions. Experimental tests of the performance of the channel simulator are presented.

  7. Channel simulation for direct detection optical communication systems

    NASA Technical Reports Server (NTRS)

    Tycz, M.; Fitzmaurice, M. W.

    1974-01-01

    A technique is described for simulating the random modulation imposed by atmospheric scintillation and transmitter pointing jitter on a direct detection optical communication system. The system is capable of providing signal fading statistics which obey log normal, beta, Rayleigh, Ricean or chi-squared density functions. Experimental tests of the performance of the Channel Simulator are presented.

  8. Eight-channel telephone telemetry system

    NASA Technical Reports Server (NTRS)

    Smith, R.; Carr, T.

    1973-01-01

    Portable telemetry system uses conventional telephone link which eliminates mailing or messenger service between physician and analyst. Transmitter is used by physician; receiver is used by analyst. Each unit is inductively coupled to its respective telephone set, transmitter converting EEG into audio frequency and receiver converting this frequency back to EEG.

  9. Wave-current interaction in evolution of rip channel system

    NASA Astrophysics Data System (ADS)

    Uchiyama, Y.; Miyazaki, D.; Kaida, H.

    2014-12-01

    Current effects on waves (CEW) have been recognized to play an essential role in attenuating offshore extent of rip currents (e.g., Haas et al., 1999; Yu and Slinn, 2003; Weir et al., 2011). This mechanism is presumed to be responsible for morphological processes of sandy beaches. The present study aims at analyzing influence of CEW on the evolution of rip channel system due to deformation of an alongshore-uniform barred topography. We exploit a phase-averaged barotropic numerical model based on ROMS with an Eulerian-averaged vortex force formalism (McWilliams et al., 2004) coupled with a refraction wave model (ROMS-WEC; Uchiyama et al., 2009; 2010). An empirical total sediment load model of Soulsby and Van Rijn (1997) with a diffusive downslope transport effect (e.g., Garnier et al., 2008) is implemented for evaluating sediment transport and associated morphological evolution. The coupled, wave-current-sediment model successfully reproduces development of the alongshore periodic rip channel topography with normal incident offshore waves. The initial alongshore-uniform barred topography evolves into a rhythmic rip channel system through intrinsic instability triggered by a small disturbance. We then exhibit the rip current reduction by CEW on an immobile single barred beach with equally spaced rip channels. Among the other CEW such as the Doppler shift and wave set-down/up, wave refraction on currents is found to be most important in modifying the wavenumber field and breaker dissipation, leading to a systematic modulation in the diagnostic momentum balance. We further demonstrate that CEW has the first-order effect on the morphological processes where the resultant rip channel spacing is elongated 25-50% as compared to the case without CEW. In particular, CEW is crucial in widening the rip channel spacing, shoaling the rip channel in the surfzone, and shrinking submerged crescent mounds in the offshore beneath rip heads.

  10. Visualization of an entangled channel spin-1 system

    SciTech Connect

    Sirsi, Swarnamala; Adiga, Veena

    2010-08-15

    Covariance matrix formalism gives powerful entanglement criteria for continuous as well as finite dimensional systems. We use this formalism to study a mixed channel spin-1 system which is well known in nuclear reactions. A spin-j state can be visualized as being made up of 2j spinors which are represented by a constellation of 2j points on a Bloch sphere using Majorana construction. We extend this formalism to visualize an entangled mixed spin-1 system.

  11. Integrated source and channel encoded digital communication system design study

    NASA Technical Reports Server (NTRS)

    Huth, G. K.; Trumpis, B. D.; Udalov, S.

    1975-01-01

    Various aspects of space shuttle communication systems were studied. The following major areas were investigated: burst error correction for shuttle command channels; performance optimization and design considerations for Costas receivers with and without bandpass limiting; experimental techniques for measuring low level spectral components of microwave signals; and potential modulation and coding techniques for the Ku-band return link. Results are presented.

  12. Channel systems and lobe construction in the Mississippi Fan

    USGS Publications Warehouse

    Garrison, L. E.; Kenyon, Neil H.; Bouma, A.H.

    1982-01-01

    Morphological features on the Mississippi Fan in the eastern Gulf of Mexico were mapped using GLORIA II, a long-range side-scan sonar system. Prominent is a sinuous channel flanked by well-developed levees and occasional crevasse splays. The channel follows the axis and thickest part of the youngest fan lobe; seismic-reflection profiles offer evidence that its course has remained essentially constant throughout lobe development. Local modification and possible erosion of levees by currents indicates a present state of inactivity. Superficial sliding has affected part of the fan lobe, but does not appear to have been a factor in lobe construction. ?? 1982 A. M. Dowden, Inc.

  13. Integrated source and channel encoded digital communications system design study

    NASA Technical Reports Server (NTRS)

    Huth, G. K.

    1974-01-01

    Studies on the digital communication system for the direct communication links from ground to space shuttle and the links involving the Tracking and Data Relay Satellite (TDRS). Three main tasks were performed:(1) Channel encoding/decoding parameter optimization for forward and reverse TDRS links,(2)integration of command encoding/decoding and channel encoding/decoding; and (3) modulation coding interface study. The general communication environment is presented to provide the necessary background for the tasks and to provide an understanding of the implications of the results of the studies.

  14. Joint Channel Estimation and Signal Detection for the OFDM System Without Cyclic Prefix Over Doubly-Selective Channels

    NASA Astrophysics Data System (ADS)

    Song, Lijun; Lei, Xia; Jin, Maozhu; Lv, Zhihan

    2015-12-01

    In the high-speed railway wireless communication, a joint channel estimation and signal detection algorithm is proposed for the orthogonal frequency division multiplexing (OFDM) system without cyclic prefix in the doubly-selective fading channels. Our proposed method first combines the basis expansion model (BEM) and the inter symbol interference (ISI) cancellation to overcome the situation that exists with the fast time-varying channel and the normalized maximum multipath channel exceeding the length of the cyclic prefix (CP). At first, the channel estimation and signal detection can be approximated without considering the ISI. Then, the channel parameters and signal detection are updated through ISI cancellation and circular convolution reconstruction from the frequency domain. The simulations show the algorithm can improve the performance of channel estimation and signal detection.

  15. Athabasca Valles, Mars: A lava-draped channel system

    USGS Publications Warehouse

    Jaeger, W.L.; Keszthelyi, L.P.; McEwen, A.S.; Dundas, C.M.; Russell, P.S.

    2007-01-01

    Athabasca Valles is a young outflow channel system on Mars that may have been carved by catastrophic water floods. However, images acquired by the High-Resolution Imaging Science Experiment camera onboard the Mars Reconnaissance Orbiter spacecraft reveal that Athabasca Valles is now entirely draped by a thin layer of solidified lava - the remnant of a once-swollen river of molten rock. The lava erupted from a fissure, inundated the channels, and drained downstream in geologically recent times. Purported ice features in Athabasca Valles and its distal basin, Cerberus Palus, are actually composed of this lava. Similar volcanic processes may have operated in other ostensibly fluvial channels, which could explain in part why the landers sent to investigate sites of ancient flooding on Mars have predominantly found lava at the surface instead.

  16. Athabasca Valles, Mars: a lava-draped channel system.

    PubMed

    Jaeger, W L; Keszthelyi, L P; McEwen, A S; Dundas, C M; Russell, P S

    2007-09-21

    Athabasca Valles is a young outflow channel system on Mars that may have been carved by catastrophic water floods. However, images acquired by the High-Resolution Imaging Science Experiment camera onboard the Mars Reconnaissance Orbiter spacecraft reveal that Athabasca Valles is now entirely draped by a thin layer of solidified lava-the remnant of a once-swollen river of molten rock. The lava erupted from a fissure, inundated the channels, and drained downstream in geologically recent times. Purported ice features in Athabasca Valles and its distal basin, Cerberus Palus, are actually composed of this lava. Similar volcanic processes may have operated in other ostensibly fluvial channels, which could explain in part why the landers sent to investigate sites of ancient flooding on Mars have predominantly found lava at the surface instead.

  17. A 96-channel neural stimulation system for driving AIROF microelectrodes.

    PubMed

    Hu, Z; Troyk, P; Cogan, S

    2004-01-01

    We present the design and testing of a 96-channel stimulation system to drive activated iridium oxide (AIROF) microelectrodes within safe charge-injection limits. Our system improves upon the traditional capacitively coupled, symmetric charge-balanced biphasic stimulation waveform so as to maximize charge-injection capacity without endangering the microelectrodes. It can deliver computer-controlled cathodic current pulse for to up to 96 AIROF microelectrodes and positively bias them during the inter-pulse interval. The stimulation system is comprised of (1) 12 custom-designed PCB boards each hosting an 8-channel ASIC chip, (2) a motherboard to communicate between these 12 boards and the PC, (3) the PC interface equipped with a DIO card and the corresponding software. We plan to use this system in animal experiments for intracortical neural stimulation of implanted electrodes within our visual prosthesis project. PMID:17271241

  18. Correcting Aberrations in Complex Magnet Systems for Muon Cooling Channels

    SciTech Connect

    J.A. Maloney, B. Erdelyi, A. Afanaciev, R.P. Johnson, Y.S. Derbenev, V.S. Morozov

    2011-03-01

    Designing and simulating complex magnet systems needed for cooling channels in both neutrino factories and muon colliders requires innovative techniques to correct for both chromatic and spherical aberrations. Optimizing complex systems, such as helical magnets for example, is also difficult but essential. By using COSY INFINITY, a differential algebra based code, the transfer and aberration maps can be examined to discover what critical terms have the greatest influence on these aberrations.

  19. A Fast Channel Switching Method in EPON System for IPTV Service

    NASA Astrophysics Data System (ADS)

    Nie, Yaling; Yoshiuchi, Hideya

    This paper presents a fast channel switching method in Ethernet Passive Optical Network (EPON) system for IPTV service. Fast channel switching is one of the important features of successful IPTV systems. Users surely prefer IPTV systems with small channel switching time rather than a longer one. Thus a channel switching control module and a channel/permission list in EPON system’s ONU or OLT is designed. When EPON system receives channel switching message from IPTV end user, the channel switching control module will catch the message and search the channel list and permission list maintained in EPON system, then got the matching parameter of EPON for the new channel. The new channel’s data transmission will be enabled by directly updating the optical filter of the ONU that end user connected. By using this method in EPON system, it provides a solution for dealing with channel switching delays in IPTV service.

  20. The effects of channel errors in DPCM systems and comparison with PCM systems.

    NASA Technical Reports Server (NTRS)

    Essman, J. E.; Wintz, P. A.

    1973-01-01

    Sampling, quantization, and channel errors in differential pulse-code modulation (DPCM) systems are considered and compared to results obtained with standard pulse-code modulation (PCM) systems. DPCM and PCM are compared for three different reconstruction filters. The optimum prediction coefficient is shown to depend on the channel noise.-

  1. The elusive character of discontinuous deep-water channels: New insights from Lucia Chica channel system, offshore California

    USGS Publications Warehouse

    Maier, K.L.; Fildani, A.; Paull, C.K.; Graham, S.A.; McHargue, T.R.; Caress, D.W.; McGann, M.

    2011-01-01

    New high-resolution autonomous underwater vehicle (AUV) seafloor images, with 1 m lateral resolution and 0.3 m vertical resolution, reveal unexpected seafloor rugosity and low-relief (<10 m), discontinuous conduits over ~70 km2. Continuous channel thalwegs were interpreted originally from lower-resolution images, but newly acquired AUV data indicate that a single sinuous channel fed a series of discontinuous lower-relief channels. These discontinuous channels were created by at least four avulsion events. Channel relief, defined as the height from the thalweg to the levee crest, controls avulsions and overall stratigraphic architecture of the depositional area. Flowstripped turbidity currents separated into and reactivated multiple channels to create a distributary pattern and developed discontinuous trains of cyclic scours and megaflutes, which may be erosional precursors to continuous channels. The diverse features now imaged in the Lucia Chica channel system (offshore California) are likely common in modern and ancient systems with similar overall morphologies, but have not been previously mapped with lower-resolution detection methods in any of these systems. ?? 2011 Geological Society of America.

  2. Channel capacity of an array system for Gaussian channels with applications to combining and noise cancellation

    NASA Technical Reports Server (NTRS)

    Cheung, K. M.; Vilnrotter, V.

    1996-01-01

    A closed-form expression for the capacity of an array of correlated Gaussian channels is derived. It is shown that when signal and noise are independent, the array of observables can be replaced with a single observable without diminishing the capacity of the array channel. Examples are provided to illustrate the dependence of channel capacity on noise correlation for two- and three-channel arrays.

  3. Sample Analysis Code System for the Dual Channel Counter.

    1994-09-14

    Version 00 RADCOMPT automates gross alpha and gross beta sample analysis calculations and, in many cases, warns the technologist when a hazard level is being approached or when it has been exceeded. The RADCOMPT program is unique in that it corrects for crosstalk between channels, and in this way provides increased accuracy and efficiency. Even though it is designed explicitly for the analyses of air samples and wipe samples, it can also be used formore » other sample types. It is designed to be used with a dual channel counter (in which one channel is used for alpha detection and the other for beta detection), but may be used with two single channel counters employed for the same purpose. In addition, it provides an automated means for the execution of the following radiological sample analyses protocol: A. Calibration of the counting system B. Calculation of sample activity or air activity concentrations (with the activities of air activity concentrations at the top and bottom of the two-sided 95 percent confidence interval also specified). C. Determination of minimum sample counting times required for detection and/or quantification of specified alpha and beta activities or air activity concentrations. In addition, alternate counting times are determined for alternate activities such that the specified alpha and beta activities are at the top of the 95% confidence interval, increasing the confidence that the activities measured are below the specified limits. D. Calculation of the minimum detectable activities or air activity concentrations. E. Determination of air sample volumes required for detection and/or quantification of specified alpha and beta air activity concentrations. F. Calculation of long-lived activities or air activity concentrations based on radon daughter and thoron daughter decay. G. Calculation of employees DAC-Hours and estimated Committed Effective Dose Equivalent. H. Varying calibration constants (to coincide with possible adjustments to

  4. Localization in chaotic systems with a single-channel opening.

    PubMed

    Lippolis, Domenico; Ryu, Jung-Wan; Kim, Sang Wook

    2015-07-01

    We introduce a single-channel opening in a random Hamiltonian and a quantized chaotic map: localization on the opening occurs as a sensible deviation of the wave-function statistics from the predictions of random matrix theory, even in the semiclassical limit. Increasing the coupling to the open channel in the quantum model, we observe a similar picture to resonance trapping, made of a few fast-decaying states, whose left (right) eigenfunctions are entirely localized on the (preimage of the) opening, and plentiful long-lived states, whose probability density is instead suppressed at the opening. For the latter, we derive and test a linear relation between the wave-function intensities and the decay rates, similar to the Breit-Wigner law. We then analyze the statistics of the eigenfunctions of the corresponding (discretized) classical propagator, finding a similar behavior to the quantum system only in the weak-coupling regime.

  5. A Multiple-Channel Sub-Band Transient Detection System

    SciTech Connect

    David A. Smith

    1998-11-01

    We have developed a unique multiple-channel sub-band transient detection system to record transient electromagnetic signals in carrier-dominated radio environments; the system has been used to make unique observations of weak, transient HF signals. The detection system has made these observations possible through improved sensitivity compared to conventional broadband transient detection systems; the sensitivity improvement is estimated to be at least 20 dB. The increase in sensitivity has been achieved through subdivision of the band of interest (an 18 MHz tunable bandwidth) into eight sub-band independent detection channels, each with a 400 kHz bandwidth and its own criteria. The system generates a system trigger signal when a predetermined number of channels (typically five) trigger within a predetermined window of time (typically 100 ~s). Events are recorded with a broadband data acquisition system sampling at 50 or 100 Msample/s, so despite the fact that the detection system operates on portions of the signal confined to narrow bands, data acquisition is broadband. Between May and September of 1994, the system was used to detect and record over six thousand transient events in the frequency band from 3 to 30 MHz. Approximately 500 of the events have been characterized as paired bursts of radio noise with individual durations of 2 to 10 ps and separations between the bursts of 5 to 160 ps. The paired transients are typically 5 to 40 dB brighter than the background electromagnetic spectrum between carrier signals. We have termed these events SubIonospheric Pulse Pairs (SIPPS) and presently have no explanation as to their source. Our observations of SIPPS resemble observations of TransIonospheric Pulse Pairs (TIPPs) recorded by the Blackboard instrument on the ALEXIS satellite; the source of TIPP events is also unknown. Most of the recorded SIPP events do not exhibit frequency dispersion, implying propagation along a line-of-sight (groundwave) path; but seven of

  6. Systems Modeling of a Hypothetical SSME Channel-Wall Nozzle

    NASA Technical Reports Server (NTRS)

    Greene, William D.; Thames, Mignon P.; Polsgrove, Robert H.

    2003-01-01

    A future upgrade to the Space Shuttle Main Engine (SSME) may be the replacement of the current regenerative cooled tube-wall nozzle with a nozzle using a regeneratively-cooled channel-wall design. The current tube-wall design represents the only major piece of SSME hardware that has not been dramatically updated throughout thc long history of the engine. There are a number of advantages to a channel-wall design including the promise of faster and lower cost fabrication and greater reliability in the field. The technical obstacles in the path of making this happen are many, particularly in the realms of metallurgy and manufacturing techniques. However, one technical area that can and should be addressed in the near term as part of the development of detailed component requirements is a systems type model of the fluid flow and heat transfer processes to which the new design will be exposed. This paper presents the results of an effort to develop a mathematical model of the internal flow for a generic channel-wall nozzle functioning as a direct replacement for the current tube-wall nozzle with a minimum of systems-level changes. Comparisons will be made to mathematical modeling results for the current tube-wall design and the results of various geometrical trade studies will be presented. It is the intent of this work to examine the feasibility of the concept of a direct replacement component with minimum systems-!eve impacts and to highlight potential areas of concern requiring further work in the future.

  7. A multi-channel instrumentation system for biosignal recording.

    PubMed

    Yu, Hong; Li, Pengfei; Xiao, Zhiming; Peng, Chung-Ching; Bashirullah, Rizwan

    2008-01-01

    This paper reports a highly integrated battery operated multi-channel instrumentation system intended for physiological signal recording. The mixed signal IC has been fabricated in standard 0.5microm 5V 3M-2P CMOS process and features 32 instrumentation amplifiers, four 8b SAR ADCs, a wireless power interface with Li-ion battery charger, low power bidirectional telemetry and FSM controller with power gating control for improved energy efficiency. The chip measures 3.2mm by 4.8mm and dissipates approximately 2.1mW when fully operational.

  8. Channeling power across ecological systems: social regularities in community organizing.

    PubMed

    Christens, Brian D; Inzeo, Paula Tran; Faust, Victoria

    2014-06-01

    Relational and social network perspectives provide opportunities for more holistic conceptualizations of phenomena of interest in community psychology, including power and empowerment. In this article, we apply these tools to build on multilevel frameworks of empowerment by proposing that networks of relationships between individuals constitute the connective spaces between ecological systems. Drawing on an example of a model for grassroots community organizing practiced by WISDOM—a statewide federation supporting local community organizing initiatives in Wisconsin—we identify social regularities (i.e., relational and temporal patterns) that promote empowerment and the development and exercise of social power through building and altering relational ties. Through an emphasis on listening-focused one-to-one meetings, reflection, and social analysis, WISDOM organizing initiatives construct and reinforce social regularities that develop social power in the organizing initiatives and advance psychological empowerment among participant leaders in organizing. These patterns are established by organizationally driven brokerage and mobilization of interpersonal ties, some of which span ecological systems.Hence, elements of these power-focused social regularities can be conceptualized as cross-system channels through which micro-level empowerment processes feed into macro-level exercise of social power, and vice versa. We describe examples of these channels in action, and offer recommendations for theory and design of future action research [corrected] .

  9. Traveling Wave RF Systems for Helical Cooling Channels

    SciTech Connect

    Yonehara, K.; Lunin, A.; Moretti, A.; Popovic, M.; Romanov, G.; Neubauer, M.; Johnson, R.P.; Thorndahl, L.; /CERN

    2009-05-01

    The great advantage of the helical ionization cooling channel (HCC) is its compact structure that enables the fast cooling of muon beam 6-dimensional phase space. This compact aspect requires a high average RF gradient, with few places that do not have cavities. Also, the muon beam is diffuse and requires an RF system with large transverse and longitudinal acceptance. A traveling wave system can address these requirements. First, the number of RF power coupling ports can be significantly reduced compared with our previous pillbox concept. Secondly, by adding a nose on the cell iris, the presence of thin metal foils traversed by the muons can possibly be avoided. We show simulations of the cooling performance of a traveling wave RF system in a HCC, including cavity geometries with inter-cell RF power couplers needed for power propagation.

  10. 47 CFR 22.757 - Channels for basic exchange telephone radio systems.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 2 2010-10-01 2010-10-01 false Channels for basic exchange telephone radio... CARRIER SERVICES PUBLIC MOBILE SERVICES Rural Radiotelephone Service Basic Exchange Telephone Radio Systems § 22.757 Channels for basic exchange telephone radio systems. The channels listed in § 22.725...

  11. 47 CFR 22.757 - Channels for basic exchange telephone radio systems.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 2 2014-10-01 2014-10-01 false Channels for basic exchange telephone radio... CARRIER SERVICES PUBLIC MOBILE SERVICES Rural Radiotelephone Service Basic Exchange Telephone Radio Systems § 22.757 Channels for basic exchange telephone radio systems. The channels listed in § 22.725...

  12. 47 CFR 22.757 - Channels for basic exchange telephone radio systems.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 2 2012-10-01 2012-10-01 false Channels for basic exchange telephone radio... CARRIER SERVICES PUBLIC MOBILE SERVICES Rural Radiotelephone Service Basic Exchange Telephone Radio Systems § 22.757 Channels for basic exchange telephone radio systems. The channels listed in § 22.725...

  13. 47 CFR 22.757 - Channels for basic exchange telephone radio systems.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 2 2011-10-01 2011-10-01 false Channels for basic exchange telephone radio... CARRIER SERVICES PUBLIC MOBILE SERVICES Rural Radiotelephone Service Basic Exchange Telephone Radio Systems § 22.757 Channels for basic exchange telephone radio systems. The channels listed in § 22.725...

  14. 47 CFR 22.757 - Channels for basic exchange telephone radio systems.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 2 2013-10-01 2013-10-01 false Channels for basic exchange telephone radio... CARRIER SERVICES PUBLIC MOBILE SERVICES Rural Radiotelephone Service Basic Exchange Telephone Radio Systems § 22.757 Channels for basic exchange telephone radio systems. The channels listed in § 22.725...

  15. A portable fNIRS system with eight channels

    NASA Astrophysics Data System (ADS)

    Si, Juanning; Zhao, Ruirui; Zhang, Yujin; Zuo, Nianming; Zhang, Xin; Jiang, Tianzi

    2015-03-01

    Abundant study on the hemodynamic response of a brain have brought quite a few advances in technologies of measuring it. The most benefitted is the functional near infrared spectroscope (fNIRS). A variety of devices have been developed for different applications. Because portable fNIRS systems were more competent to measure responses either of special subjects or in natural environment, several kinds of portable fNIRS systems have been reported. However, they all required a computer for receiving data. The extra computer increases the cost of a fNIRS system. What's more noticeable is the space required to locate the computer even for a portable system. It will discount the portability of the fNIRS system. So we designed a self-contained eight channel fNIRS system, which does not demand a computer to receive data and display data in a monitor. Instead, the system is centered by an ARM core CPU, which takes charge in organizing data and saving data, and then displays data on a touch screen. The system has also been validated by experiments on phantoms and on subjects in tasks.

  16. Single transmission line interrogated multiple channel data acquisition system

    DOEpatents

    Fasching, George E.; Keech, Jr., Thomas W.

    1980-01-01

    A single transmission line interrogated multiple channel data acquisition system is provided in which a plurality of remote station/sensor circuits each monitors a specific process variable and each transmits measurement values over a single transmission line to a master interrogating station when addressed by said master interrogating station. Typically, as many as 330 remote stations may be parallel connected to the transmission line which may exceed 7,000 feet. The interrogation rate is typically 330 stations/second. The master interrogating station samples each station according to a shared, charging transmit-receive cycle. All remote station address signals, all data signals from the remote stations/sensors and all power for all of the remote station/sensors are transmitted via a single continuous terminated coaxial cable. A means is provided for periodically and remotely calibrating all remote sensors for zero and span. A provision is available to remotely disconnect any selected sensor station from the main transmission line.

  17. Miniaturized multi channel infrared optical gas sensor system

    NASA Astrophysics Data System (ADS)

    Wöllenstein, Jürgen; Eberhardt, Andre; Rademacher, Sven; Schmitt, Katrin

    2011-06-01

    Infrared spectroscopy uses the characteristic absorption of the molecules in the mid infrared and allows the determination of the gases and their concentration. Especially by the absorption at longer wavelengths between 8 μm and 12 μm, the so called "fingerprint" region, the molecules can be measured with highest selectivity. We present an infrared optical filter photometer for the analytical determination of trace gases in the air. The challenge in developing the filter photometer was the construction of a multi-channel system using a novel filter wheel concept - which acts as a chopper too- in order to measure simultaneously four gases: carbon monoxide, carbon dioxide, methane and ammonia. The system consists of a broadband infrared emitter, a long path cell with 1.7m optical path length, a filter wheel and analogue and digital signal processing. Multi channel filter photometers normally need one filter and one detector per target gas. There are small detection units with one, two or more detectors with integrated filters available on the market. One filter is normally used as reference at a wavelength without any cross-sensitivities to possible interfering gases (e.g. at 3.95 μm is an "atmospheric window" - a small spectral band without absorbing gases in the atmosphere). The advantage of a filter-wheel set-up is that a single IR-detector can be used, which reduces the signal drift enormously. Pyroelectric and thermopile detectors are often integrated in these kinds of spectrometers. For both detector types a modulation of the light is required and can be done - without an additional chopper - with the filter wheel.

  18. Control system devices : architectures and supply channels overview.

    SciTech Connect

    Trent, Jason; Atkins, William Dee; Schwartz, Moses Daniel; Mulder, John C.

    2010-08-01

    This report describes a research project to examine the hardware used in automated control systems like those that control the electric grid. This report provides an overview of the vendors, architectures, and supply channels for a number of control system devices. The research itself represents an attempt to probe more deeply into the area of programmable logic controllers (PLCs) - the specialized digital computers that control individual processes within supervisory control and data acquisition (SCADA) systems. The report (1) provides an overview of control system networks and PLC architecture, (2) furnishes profiles for the top eight vendors in the PLC industry, (3) discusses the communications protocols used in different industries, and (4) analyzes the hardware used in several PLC devices. As part of the project, several PLCs were disassembled to identify constituent components. That information will direct the next step of the research, which will greatly increase our understanding of PLC security in both the hardware and software areas. Such an understanding is vital for discerning the potential national security impact of security flaws in these devices, as well as for developing proactive countermeasures.

  19. In-service communication channel sensing based on reflectometry for TWDM-PON systems

    NASA Astrophysics Data System (ADS)

    Iida, Daisuke; Kuwano, Shigeru; Terada, Jun

    2014-05-01

    Many base stations are accommodated in TWDM-PON based mobile backhaul and fronthaul networks for future radio access, and failed connections in an optical network unit (ONU) wavelength channel severely degrade system performance. A cost effective in-service ONU wavelength channel monitor is essential to ensure proper system operation without failed connections. To address this issue we propose a reflectometry-based remote sensing method that provides wavelength channel information with the optical line terminal (OLT)-ONU distance. The method realizes real-time monitoring of ONU wavelength channels without signal quality degradation. Experimental results show it achieves wavelength channel distinction with high distance resolution.

  20. Speed of disentanglement in multiqubit systems under a depolarizing channel

    SciTech Connect

    Zhang, Fu-Lin Jiang, Yue; Liang, Mai-Lin

    2013-06-15

    We investigate the speed of disentanglement in the multiqubit systems under the local depolarizing channel, in which each qubit is independently coupled to the environment. We focus on the bipartition entanglement between one qubit and the remaining qubits constituting the system, which is measured by the negativity. For the two-qubit system, the speed for the pure state completely depends on its entanglement. The upper and lower bounds of the speed for arbitrary two-qubit states, and the necessary conditions for a state achieving them, are obtained. For the three-qubit system, we study the speed for pure states, whose entanglement properties can be completely described by five local-unitary-transformation invariants. An analytical expression of the relation between the speed and the invariants is derived. The speed is enhanced by the three-tangle which is the entanglement among the three qubits, but reduced by the two-qubit correlations outside the concurrence. The decay of the negativity can be restrained by the other two negativity with the coequal sense. The unbalance between two qubits can reduce the speed of disentanglement of the remaining qubit in the system, and even can retrieve the entanglement partially. For the k-qubit systems in an arbitrary superposition of Greenberger–Horne–Zeilinger state and W state, the speed depends almost entirely on the amount of the negativity when k increases to five or six. An alternative quantitative definition for the robustness of entanglement is presented based on the speed of disentanglement, with comparison to the widely studied robustness measured by the critical amount of noise parameter where the entanglement vanishes. In the limit of large number of particles, the alternative robustness of the Greenberger–Horne–Zeilinger-type states is inversely proportional to k, and the one of the W states approaches 1/√(k)

  1. Viral potassium channels as a robust model system for studies of membrane-protein interaction.

    PubMed

    Braun, Christian J; Lachnit, Christine; Becker, Patrick; Henkes, Leonhard M; Arrigoni, Cristina; Kast, Stefan M; Moroni, Anna; Thiel, Gerhard; Schroeder, Indra

    2014-04-01

    The viral channel KcvNTS belongs to the smallest K(+) channels known so far. A monomer of a functional homotetramer contains only 82 amino acids. As a consequence of the small size the protein is almost fully submerged into the membrane. This suggests that the channel is presumably sensitive to its lipid environment. Here we perform a comparative analysis for the function of the channel protein embedded in three different membrane environments. 1. Single-channel currents of KcvNTS were recorded with the patch clamp method on the plasma membrane of HEK293 cells. 2. They were also measured after reconstitution of recombinant channel protein into classical planar lipid bilayers and 3. into horizontal bilayers derived from giant unilamellar vesicles (GUVs). The recombinant channel protein was either expressed and purified from Pichia pastoris or from a cell-free expression system; for the latter a new approach with nanolipoprotein particles was used. The data show that single-channel activity can be recorded under all experimental conditions. The main functional features of the channel like a large single-channel conductance (80pS), high open-probability (>50%) and the approximate duration of open and closed dwell times are maintained in all experimental systems. An apparent difference between the approaches was only observed with respect to the unitary conductance, which was ca. 35% lower in HEK293 cells than in the other systems. The reason for this might be explained by the fact that the channel is tagged by GFP when expressed in HEK293 cells. Collectively the data demonstrate that the small viral channel exhibits a robust function in different experimental systems. This justifies an extrapolation of functional data from these systems to the potential performance of the channel in the virus/host interaction. This article is part of a Special Issue entitled: Viral Membrane Proteins-Channels for Cellular Networking. PMID:23791706

  2. Entanglement Dynamics of the Mixed Two-qubit System in Different Noisy Channels

    NASA Astrophysics Data System (ADS)

    Ma, Jing; Jiang, Li-Nan; Yu, Si-Yuan; Ran, Qi-Wen; Tan, Li-Ying

    2014-11-01

    We investigate the entanglement dynamics of the two-qubit entanglement quantum system when they transmitted through the Pauli channels and the depolarizing channel both independently or collectively. Making use of the concurrence we found that the entanglement of a kind of mixed two-qubit system defined in this paper can be preserved in the collective Pauli σ y noise channel, but the entanglement of the other kind of mixed two-qubit system can be preserved in the collective Pauli σ z noise channel. Meanwhile, our quantum systems will undergoing the entanglement sudden death (ESD) in collective depolarizing channel when they return to the maximally entangled Bell states. The reason is the Landblad operators in depolarizing channel are non-commuting operators and this finding is in accord with the previous study.

  3. Compressive sensing based Bayesian sparse channel estimation for OFDM communication systems: high performance and low complexity.

    PubMed

    Gui, Guan; Xu, Li; Shan, Lin; Adachi, Fumiyuki

    2014-01-01

    In orthogonal frequency division modulation (OFDM) communication systems, channel state information (CSI) is required at receiver due to the fact that frequency-selective fading channel leads to disgusting intersymbol interference (ISI) over data transmission. Broadband channel model is often described by very few dominant channel taps and they can be probed by compressive sensing based sparse channel estimation (SCE) methods, for example, orthogonal matching pursuit algorithm, which can take the advantage of sparse structure effectively in the channel as for prior information. However, these developed methods are vulnerable to both noise interference and column coherence of training signal matrix. In other words, the primary objective of these conventional methods is to catch the dominant channel taps without a report of posterior channel uncertainty. To improve the estimation performance, we proposed a compressive sensing based Bayesian sparse channel estimation (BSCE) method which cannot only exploit the channel sparsity but also mitigate the unexpected channel uncertainty without scarifying any computational complexity. The proposed method can reveal potential ambiguity among multiple channel estimators that are ambiguous due to observation noise or correlation interference among columns in the training matrix. Computer simulations show that proposed method can improve the estimation performance when comparing with conventional SCE methods.

  4. K/Ka-band channel characterization for mobile satellite systems

    NASA Technical Reports Server (NTRS)

    Pinck, Deborah S.; Rice, Michael D.

    1995-01-01

    Mobile satellite systems allow truly ubiquitous wireless communications to users anywhere and anytime. NASA's Advanced Communications Technology Satellite (ACTS) provides an ideal space-based platform for the measurement of K/Ka band propagation characteristics in a land mobile satellite application. Field tests conducted in Southern California during the first seven months of 1994 using JPL's ACTS Mobile Terminal (AMT) provided channel characterization data for the K/Ka-band link. A pilot tone was transmitted from a fixed station in Cleveland, Ohio through the satellite and downlinked at 20 GHz in the Southern California spot beam. The AMT was equipped with a narrow beam, high gain antenna which tracked the satellite in azimuth for a fixed elevation angle (46 degrees for this case). The field tests were conducted in three basic environments: clear line-of-sight (LOS) highways, lightly shadowed suburban, and heavily shadowed suburban. Preliminary results of these field tests indicate very little multipath for rural environments and for clear LOS links (as expected with a narrow beam antenna). Deep fades were experienced in shadowed areas, especially those where tree canopies covered the road.

  5. The activity of the TRP-like channel depends on its expression system

    PubMed Central

    Lev, Shaya; Katz, Ben; Minke, Baruch

    2012-01-01

    The Drosophila light activated TRP and TRPL channels have been a model for TRPC channel gating. Several gating mechanisms have been proposed following experiments conducted on photoreceptor and tissue cultured cells. However, conclusive evidence for any mechanism is still lacking. Here, we show that the Drosophila TRPL channel expressed in tissue cultured cells is constitutively active in S2 cells but is silent in HEK cells. Modulations of TRPL channel activity in different expression system by pharmacology or specific enzymes, which change the lipid content of the plasma membrane, resulted in conflicting effects. These findings demonstrate the difficulty in elucidating TRPC gating, as channel behavior is expression system dependent. However, clues on the gating mechanism may arise from understanding how different expression systems affect TRPC channel activation. PMID:22627924

  6. Average capacity for optical wireless communication systems over exponentiated Weibull distribution non-Kolmogorov turbulent channels.

    PubMed

    Cheng, Mingjian; Zhang, Yixin; Gao, Jie; Wang, Fei; Zhao, Fengsheng

    2014-06-20

    We model the average channel capacity of optical wireless communication systems for cases of weak to strong turbulence channels, using the exponentiation Weibull distribution model. The joint effects of the beam wander and spread, pointing errors, atmospheric attenuation, and the spectral index of non-Kolmogorov turbulence on system performance are included. Our results show that the average capacity decreases steeply as the propagation length L changes from 0 to 200 m and decreases slowly down or tends to a stable value as the propagation length L is greater than 200 m. In the weak turbulence region, by increasing the detection aperture, we can improve the average channel capacity and the atmospheric visibility as an important issue affecting the average channel capacity. In the strong turbulence region, the increase of the radius of the detection aperture cannot reduce the effects of the atmospheric turbulence on the average channel capacity, and the effect of atmospheric visibility on the channel information capacity can be ignored. The effect of the spectral power exponent on the average channel capacity in the strong turbulence region is higher than weak turbulence region. Irrespective of the details determining the turbulent channel, we can say that pointing errors have a significant effect on the average channel capacity of optical wireless communication systems in turbulence channels.

  7. Performance of a temperate-zone channel catfish biofloc technology production system during winter

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Channel catfish (Ictalurus punctatus) have been grown successfully in an outdoor biofloc technology production system. Outdoor biofloc production systems in the tropics are operated year-round, whereas the channel catfish studies were conducted only during the growing season and biofloc production t...

  8. 47 CFR 22.857 - Channel plan for commercial aviation air-ground systems.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 2 2013-10-01 2013-10-01 false Channel plan for commercial aviation air-ground... CARRIER SERVICES PUBLIC MOBILE SERVICES Air-Ground Radiotelephone Service Commercial Aviation Air-Ground Systems § 22.857 Channel plan for commercial aviation air-ground systems. The 849-851 MHz and 894-896...

  9. 47 CFR 22.857 - Channel plan for commercial aviation air-ground systems.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 2 2010-10-01 2010-10-01 false Channel plan for commercial aviation air-ground... CARRIER SERVICES PUBLIC MOBILE SERVICES Air-Ground Radiotelephone Service Commercial Aviation Air-Ground Systems § 22.857 Channel plan for commercial aviation air-ground systems. The 849-851 MHz and 894-896...

  10. 47 CFR 22.857 - Channel plan for commercial aviation air-ground systems.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 2 2012-10-01 2012-10-01 false Channel plan for commercial aviation air-ground... CARRIER SERVICES PUBLIC MOBILE SERVICES Air-Ground Radiotelephone Service Commercial Aviation Air-Ground Systems § 22.857 Channel plan for commercial aviation air-ground systems. The 849-851 MHz and 894-896...

  11. 47 CFR 22.857 - Channel plan for commercial aviation air-ground systems.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 2 2014-10-01 2014-10-01 false Channel plan for commercial aviation air-ground... CARRIER SERVICES PUBLIC MOBILE SERVICES Air-Ground Radiotelephone Service Commercial Aviation Air-Ground Systems § 22.857 Channel plan for commercial aviation air-ground systems. The 849-851 MHz and 894-896...

  12. 47 CFR 22.857 - Channel plan for commercial aviation air-ground systems.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 2 2011-10-01 2011-10-01 false Channel plan for commercial aviation air-ground... CARRIER SERVICES PUBLIC MOBILE SERVICES Air-Ground Radiotelephone Service Commercial Aviation Air-Ground Systems § 22.857 Channel plan for commercial aviation air-ground systems. The 849-851 MHz and 894-896...

  13. Performance Characterization of a Hybrid Satellite-Terrestrial System with Co-Channel Interference over Generalized Fading Channels.

    PubMed

    Javed, Umer; He, Di; Liu, Peilin

    2016-08-05

    The transmission of signals in a hybrid satellite-terrestrial system (HSTS) in the presence of co-channel interference (CCI) is considered in this study. Specifically, we examine the problem of amplify-and-forward (AF)-based relaying in a hybrid satellite-terrestrial link, where the relay node is operating in the presence of a dominant co-channel interferer. It is assumed that direct connection between a source node (satellite) and a destination node (terrestrial receiver) is not available due to masking by obstacles in the surrounding. The destination node is only able to receive signals from the satellite with the help of a relay node located at the ground. In the proposed HSTS, the satellite-relay channel follows the shadowed Rice fading; and the channels of interferer-relay and relay-destination links experience generalized Nakagami-m fading. For the considered AF-based HSTS, we first develop the analytical expression for the moment generating function (MGF) of the overall output signal-to-interference-plus-noise ratio (SINR). Then, based on the derived exact MGF, we derive novel expressions for the average symbol error rate (SER) of the considered HSTS for the following digital modulation techniques: M-ary phase shift keying (M-PSK), M-ary quadrature amplitude modulation (M-QAM) and M-ary pulse amplitude modulation (M-PAM). To significantly reduce the computational complexity for utility in system-level simulations, simple analytical approximation for the exact SER in the high signal-to-noise ratio (SNR) regime is presented to provide key insights. Finally, numerical results and the corresponding analysis are presented to demonstrate the effectiveness of the developed performance evaluation framework and to view the impact of CCI on the considered HSTS under varying channel conditions and with different modulation schemes.

  14. Performance Characterization of a Hybrid Satellite-Terrestrial System with Co-Channel Interference over Generalized Fading Channels

    PubMed Central

    Javed, Umer; He, Di; Liu, Peilin

    2016-01-01

    The transmission of signals in a hybrid satellite-terrestrial system (HSTS) in the presence of co-channel interference (CCI) is considered in this study. Specifically, we examine the problem of amplify-and-forward (AF)-based relaying in a hybrid satellite-terrestrial link, where the relay node is operating in the presence of a dominant co-channel interferer. It is assumed that direct connection between a source node (satellite) and a destination node (terrestrial receiver) is not available due to masking by obstacles in the surrounding. The destination node is only able to receive signals from the satellite with the help of a relay node located at the ground. In the proposed HSTS, the satellite-relay channel follows the shadowed Rice fading; and the channels of interferer-relay and relay-destination links experience generalized Nakagami-m fading. For the considered AF-based HSTS, we first develop the analytical expression for the moment generating function (MGF) of the overall output signal-to-interference-plus-noise ratio (SINR). Then, based on the derived exact MGF, we derive novel expressions for the average symbol error rate (SER) of the considered HSTS for the following digital modulation techniques: M-ary phase shift keying (M-PSK), M-ary quadrature amplitude modulation (M-QAM) and M-ary pulse amplitude modulation (M-PAM). To significantly reduce the computational complexity for utility in system-level simulations, simple analytical approximation for the exact SER in the high signal-to-noise ratio (SNR) regime is presented to provide key insights. Finally, numerical results and the corresponding analysis are presented to demonstrate the effectiveness of the developed performance evaluation framework and to view the impact of CCI on the considered HSTS under varying channel conditions and with different modulation schemes. PMID:27527182

  15. Performance Characterization of a Hybrid Satellite-Terrestrial System with Co-Channel Interference over Generalized Fading Channels.

    PubMed

    Javed, Umer; He, Di; Liu, Peilin

    2016-01-01

    The transmission of signals in a hybrid satellite-terrestrial system (HSTS) in the presence of co-channel interference (CCI) is considered in this study. Specifically, we examine the problem of amplify-and-forward (AF)-based relaying in a hybrid satellite-terrestrial link, where the relay node is operating in the presence of a dominant co-channel interferer. It is assumed that direct connection between a source node (satellite) and a destination node (terrestrial receiver) is not available due to masking by obstacles in the surrounding. The destination node is only able to receive signals from the satellite with the help of a relay node located at the ground. In the proposed HSTS, the satellite-relay channel follows the shadowed Rice fading; and the channels of interferer-relay and relay-destination links experience generalized Nakagami-m fading. For the considered AF-based HSTS, we first develop the analytical expression for the moment generating function (MGF) of the overall output signal-to-interference-plus-noise ratio (SINR). Then, based on the derived exact MGF, we derive novel expressions for the average symbol error rate (SER) of the considered HSTS for the following digital modulation techniques: M-ary phase shift keying (M-PSK), M-ary quadrature amplitude modulation (M-QAM) and M-ary pulse amplitude modulation (M-PAM). To significantly reduce the computational complexity for utility in system-level simulations, simple analytical approximation for the exact SER in the high signal-to-noise ratio (SNR) regime is presented to provide key insights. Finally, numerical results and the corresponding analysis are presented to demonstrate the effectiveness of the developed performance evaluation framework and to view the impact of CCI on the considered HSTS under varying channel conditions and with different modulation schemes. PMID:27527182

  16. Drainage systems associated with mid-ocean channels and submarine Yazoos: Alternative to submarine fan depositional systems

    SciTech Connect

    Hesse, R. )

    1989-12-01

    Submarine drainage systems associated with mid-ocean channels and Yazoo River-type tributaries in small ocean basins represent a contrast to deep-sea fan depositional systems. Deep-sea fans are diverging sediment-dispersal systems of distributary fan valleys. Deep-sea channel-submarine-yazoo systems, on the other hand, form centripetally converging patterns of tributaries and yazoo-type satellite channels that join a major basin-draining (mid-ocean) channel. The facies model for such systems is characterized by randomly stacked fining-upward, gravelly, and sandy channel-fill and submarine point-bar sequences of the main channel encased in fine-grained overbank deposits. Second-order channels contain sandy proximal overbank deposits, whereas the levees of the main channel are predominantly composed of silt and clay. Second-order channels may be braided and may broaden into braid plains. Morphology and surficial sediment distribution have been studied within the Northwest Atlantic Mid-Ocean Channel of the Labrador Sea and its associated levees and yazoo-type (and other) tributaries.

  17. Channel pattern and river-floodplain dynamics in forested mountain river systems

    NASA Astrophysics Data System (ADS)

    Beechie, Timothy J.; Liermann, Martin; Pollock, Michael M.; Baker, Sarah; Davies, Jeremy

    2006-08-01

    Channel pattern effectively stratifies the dynamics of rivers and floodplains in forested mountain river systems of the Pacific Northwest, USA. Straight channels are least dynamic, with relatively slow floodplain turnover and floodplains dominated by old surfaces. Braided channels are most dynamic, with floodplain turnover as low as 25 years and predominantly young floodplain surfaces. Island-braided and meandering channels have intermediate dynamics, with moderately frequent disturbances (erosion of floodplain patches) maintaining a mix of old and young surfaces. Return intervals for the erosion of floodplains increase in the order of braided, island-braided, meandering, and straight (8, 33, 60, and 89 years, respectively). A threshold for the lateral migration of a channel occurs at a bankfull width of 15-20 m. The most likely mechanism underlying this threshold is that larger channels are deep enough to erode below the rooting zone of bank vegetation. Above this threshold, channels not confined between valley walls exhibit channel patterns distinguishable by slope and discharge, and slope-discharge domains can be used to predict channel patterns. Meandering and braided patterns are most consistently identified by the model, and prediction errors are largely associated with indistinct transitions among channel patterns that are adjacent in plots of slope against discharge. Locations of straight channels are difficult to identify accurately with the current model. The predicted spatial distribution of channel patterns reflects a downstream decline in channel slope, which is likely correlated with a declining ratio of bed load to suspended load. Ecological theory suggests that biological diversity should be highest where the intermediate disturbance regime of island-braided channels sustains high diversity of habitat and successional states through time.

  18. A three-channel miniaturized optical system for multi-resolution imaging

    NASA Astrophysics Data System (ADS)

    Belay, Gebirie Y.; Ottevaere, Heidi; Meuret, Youri; Thienpont, Hugo

    2013-09-01

    Inspired by the natural compound eyes of insects, multichannel imaging systems embrace many channels that scramble their entire Field-Of-View (FOV). Our aim in this work was to attain multi-resolution capability into a multi-channel imaging system by manipulating the available channels to possess different imaging properties (focal length, angular resolution). We have designed a three-channel imaging system where the first and third channels have highest and lowest angular resolution of 0.0096° and 0.078° and narrowest and widest FOVs of 7° and 80°, respectively. The design of the channels has been done for a single wavelength of 587.6 nm using CODE V. The three channels each consist of 4 aspherical lens surfaces and an absorbing baffle that avoids crosstalk among the neighbouring channels. The aspherical lens surfaces have been fabricated in PMMA by ultra-precision diamond tooling and the baffles by metal additive manufacturing. The profiles of the fabricated lens surfaces have been measured with an accurate multi-sensor coordinate measuring machine and compared with the corresponding profiles of the designed lens surfaces. The fabricated lens profiles are then incorporated into CODE V to realistically model the three channels and also compare their performances with those of the nominal design. We can conclude that the performances of the two latter models are in a good agreement.

  19. A wideband channel model for land mobile satellite systems

    NASA Technical Reports Server (NTRS)

    Jahn, Axel; Buonomo, Sergio; Sforza, Mario; Lutz, Erich

    1995-01-01

    A wideband channel model for Land Mobile Satellite (LMS) services is presented which characterizes the time-varying transmission channel between a satellite and a mobile user terminal. The channel model statistic parameters are the results of fitting procedures to measured data. The data used for fitting have a time resolution of 33 ns corresponding to a bandwidth of 30 MHz. Thus, the model is capable to characterize the channel behaviour for a wide range of services e.g., voice transmission, digital audio broadcasting (DAB), and spread spectrum modulation schemes. The model is presented for different environments and scenarios. The model is derived for a quasi-mobile user with hand-held terminal being in two different environments: rural and urban. The parameters needed for the description are (a) the number of echoes, (b) the distribution of the echo power, and (c) the distribution of the echo delay. It is shown that the direct path follows a Rician distribution whereas the reflected paths are Rayleigh/lognormal distributed. The parameters are given for an elevation angle of 25 deg.

  20. Pricing strategy in a dual-channel and remanufacturing supply chain system

    NASA Astrophysics Data System (ADS)

    Jiang, Chengzhi; Xu, Feng; Sheng, Zhaohan

    2010-07-01

    This article addresses the pricing strategy problems in a supply chain system where the manufacturer sells original products and remanufactured products via indirect retailer channels and direct Internet channels. Due to the complexity of that system, agent technologies that provide a new way for analysing complex systems are used for modelling. Meanwhile, in order to reduce the computational load of searching procedure for optimal prices and profits, a learning search algorithm is designed and implemented within the multi-agent supply chain model. The simulation results show that the proposed model can find out optimal prices of original products and remanufactured products in both channels, which lead to optimal profits of the manufacturer and the retailer. It is also found that the optimal profits are increased by introducing direct channel and remanufacturing. Furthermore, the effect of customer preference, direct channel cost and remanufactured unit cost on optimal prices and profits are examined.

  1. Wireless Channel Characterization in the 5 GHz Microwave Landing System Extension Band for Airport Surface Areas

    NASA Technical Reports Server (NTRS)

    Matolak, David W.

    2007-01-01

    In this project final report, entitled "Wireless Channel Characterization in the 5 GHz Microwave Landing System Extension Band for Airport Surface Areas," we provide a detailed description and model representation for the wireless channel in the airport surface environment in this band. In this executive summary, we review report contents, describe the achieved objectives and major findings, and highlight significant conclusions and recommendations.

  2. Destiny-yield relationship for channel catfish reared in a biofloc technology production system

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The effect of stocking density on yield of stocker channel catfish and water quality in a biofloc technology production system was studied in this completely randomized design experiment. Fingerling channel catfish (Ictalurus punctatus; 48.0 g/fish, 17.8 cm/fish) were stocked into nine continuously ...

  3. Solving non-Markovian open quantum systems with multi-channel reservoir coupling

    SciTech Connect

    Broadbent, Curtis J.; Jing, Jun; Yu, Ting; Eberly, Joseph H.

    2012-08-15

    We extend the non-Markovian quantum state diffusion (QSD) equation to open quantum systems which exhibit multi-channel coupling to a harmonic oscillator reservoir. Open quantum systems which have multi-channel reservoir coupling are those in which canonical transformation of reservoir modes cannot reduce the number of reservoir operators appearing in the interaction Hamiltonian to one. We show that the non-Markovian QSD equation for multi-channel reservoir coupling can, in some cases, lead to an exact master equation which we derive. We then derive the exact master equation for the three-level system in a vee-type configuration which has multi-channel reservoir coupling and give the analytical solution. Finally, we examine the evolution of the three-level vee-type system with generalized Ornstein-Uhlenbeck reservoir correlations numerically. - Highlights: Black-Right-Pointing-Pointer The concept of multi-channel vs. single-channel reservoir coupling is rigorously defined. Black-Right-Pointing-Pointer The non-Markovian quantum state diffusion equation for arbitrary multi-channel reservoir coupling is derived. Black-Right-Pointing-Pointer An exact time-local master equation is derived under certain conditions. Black-Right-Pointing-Pointer The analytical solution to the three-level system in a vee-type configuration is found. Black-Right-Pointing-Pointer The evolution of the three-level system under generalized Ornstein-Uhlenbeck noise is plotted for many parameter regimes.

  4. 47 CFR 90.717 - Channels available for nationwide systems in the 220-222 MHz band.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Licensing and Use of Frequencies in the 220-222 MHz Band § 90.717 Channels available for nationwide systems in the 220-222 MHz band. (a) Channels 51-60, 81-90, and 141-150 are 10-channel blocks available to..., and 156-160 are 5-channel blocks available to non-Government applicants only for...

  5. 47 CFR 90.717 - Channels available for nationwide systems in the 220-222 MHz band.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Licensing and Use of Frequencies in the 220-222 MHz Band § 90.717 Channels available for nationwide systems in the 220-222 MHz band. (a) Channels 51-60, 81-90, and 141-150 are 10-channel blocks available to..., and 156-160 are 5-channel blocks available to non-Government applicants only for...

  6. A tone-aided dual vestigial sideband system for digital communications on fading channels

    NASA Technical Reports Server (NTRS)

    Hladik, Stephen M.; Saulnier, Gary J.; Rafferty, William

    1989-01-01

    A spectrally efficient tone-aided dual vestigial sideband (TA/DVSB) system for digital data communications on fading channels is presented and described analytically. This PSK (phase-shift-keying) system incorporates a feed-forward, tone-aided demodulation technique to compensate for Doppler frequency shift and channel- induced, multipath fading. In contrast to other tone-in-band-type systems, receiver synchronization is derived from the complete data VSBs. Simulation results for the Rician fading channel are presented. These results demonstrate the receiver's ability to mitigate performance degradation due to fading and to obtain proper data carrier synchronization, suggesting that the proposed TA/DVSB system has promise for this application. Simulated BER (bit-error rate) data indicate that the TA/DVSB system effectively alleviates the channel distortions of the land mobile satellite application.

  7. Video-conversion channel of a synthesizing visualization system

    NASA Astrophysics Data System (ADS)

    Bogdaov, V. V.; Kovalev, A. M.; Nefedov, I. B.; Ponomarev, N. M.; Seroshtan, A. S.

    1986-08-01

    A video-conversion channel is described in which an analog video signal is generated according to the digital description of the video subject composed in terms of geometric primitives (line segments). The device contains units for the interpolation of object color, the simulation of atmospheric phenomena (e.g., fog and haze), the filtering of quantized images, and the gamma correction of the video signal.

  8. Pilot Beam Pattern Design for Channel Estimation in Massive MIMO Systems

    NASA Astrophysics Data System (ADS)

    Noh, Song; Zoltowski, Michael D.; Sung, Youngchul; Love, David J.

    2014-10-01

    In this paper, the problem of pilot beam pattern design for channel estimation in massive multiple-input multiple-output systems with a large number of transmit antennas at the base station is considered, and a new algorithm for pilot beam pattern design for optimal channel estimation is proposed under the assumption that the channel is a stationary Gauss-Markov random process. The proposed algorithm designs the pilot beam pattern sequentially by exploiting the properties of Kalman filtering and the associated prediction error covariance matrices and also the channel statistics such as spatial and temporal channel correlation. The resulting design generates a sequentially-optimal sequence of pilot beam patterns with low complexity for a given set of system parameters. Numerical results show the effectiveness of the proposed algorithm.

  9. Global coverage Mobile Satellite Systems: System availability versus channel propagation impairments

    NASA Technical Reports Server (NTRS)

    Sforza, M.; Buonomo, S.; Poiaresbaptista, J. P. V.

    1993-01-01

    Mobile Satellite Systems (MSS) in Highly Elliptical (HEO) and circular Earth orbits at Medium (MEO) and Low (LEO) altitudes have been intensively studied in the last few years as an effective means of providing global communication services. Such global coverage MSS networks are also expected to mitigate typical channel impairments usually encountered in geostationary Land Mobile Satellite (LMS) systems. In the design stages of these satellite networks, information regarding the mobile propagation channel is needed to assess the overall link availability versus elevation angle and environmental scenarios. For multisatellite LMS configurations, the mobile user on the Earth surface sees, at any given time, more than one satellite of the constellation. In our paper, it is shown that, under certain working assumptions regarding the statistics of the propagation channel, an improvement of the link availability may be achieved through the use of a multisatellite constellation. The analyses have been carried out using the European Space Agency (ESA) LMS propagation data base which presently covers a wide range of elevation angles and environmental scenarios.

  10. Pulse-excited, auto-zeroing multiple channel data transmission system

    DOEpatents

    Fasching, George E.

    1987-01-01

    A multiple channel data transmission system is provided in which signals from a plurality of pulse operated transducers and a corresponding plurality of pulse operated signal processor channels are multiplexed for single channel FM transmission to a receiving station. The transducers and corresponding channel amplifiers are powered by pulsing the dc battery power to these devices to conserve energy and battery size for long-term data transmission from remote or inaccessible locations. Auto zeroing of the signal channel amplifiers to compensate for drift associated with temperature changes, battery decay, component aging, etc., in each channel is accomplished by means of a unique auto zero feature which between signal pulses holds a zero correction voltage on an integrating capacitor coupled to the corresponding channel amplifier output. Pseudo-continuous outputs for each channel are achieved by pulsed sample-and-hold circuits which are updated at the pulsed operation rate. The sample-and-hold outputs are multiplexed into an FM/FM transmitter for transmission to an FM receiver station for demultiplexing and storage in separate channel recorders.

  11. Pulse-excited, auto-zeroing multiple channel data transmission system

    DOEpatents

    Fasching, G.E.

    1985-02-22

    A multiple channel data transmission system is provided in which signals from a plurality of pulse operated transducers and a corresponding plurality of pulse operated signal processor channels are multiplexed for single channel FM transmission to a receiving station. The transducers and corresponding channel amplifiers are powered by pulsing the dc battery power to these devices to conserve energy and battery size for long-term data transmission from remote or inaccessible locations. Auto zeroing of the signal channel amplifiers to compensate for drift associated with temperature changes, battery decay, component aging, etc., in each channel is accomplished by means of a unique auto zero feature which between signal pulses holds a zero correction voltage on an integrating capacitor coupled to the corresponding channel amplifier output. Pseudo-continuous outputs for each channel are achieved by pulsed sample-and-hold circuits which are updated at the pulsed operation rate. The sample-and-hold outputs are multiplexed into an FM/FM transmitter for transmission to an FM receiver station for demultiplexing and storage in separate channel recorders.

  12. Therapeutic targeting of two-pore-domain potassium (K(2P)) channels in the cardiovascular system.

    PubMed

    Wiedmann, Felix; Schmidt, Constanze; Lugenbiel, Patrick; Staudacher, Ingo; Rahm, Ann-Kathrin; Seyler, Claudia; Schweizer, Patrick A; Katus, Hugo A; Thomas, Dierk

    2016-05-01

    The improvement of treatment strategies in cardiovascular medicine is an ongoing process that requires constant optimization. The ability of a therapeutic intervention to prevent cardiovascular pathology largely depends on its capacity to suppress the underlying mechanisms. Attenuation or reversal of disease-specific pathways has emerged as a promising paradigm, providing a mechanistic rationale for patient-tailored therapy. Two-pore-domain K(+) (K(2P)) channels conduct outward K(+) currents that stabilize the resting membrane potential and facilitate action potential repolarization. K(2P) expression in the cardiovascular system and polymodal K2P current regulation suggest functional significance and potential therapeutic roles of the channels. Recent work has focused primarily on K(2P)1.1 [tandem of pore domains in a weak inwardly rectifying K(+) channel (TWIK)-1], K(2P)2.1 [TWIK-related K(+) channel (TREK)-1], and K(2P)3.1 [TWIK-related acid-sensitive K(+) channel (TASK)-1] channels and their role in heart and vessels. K(2P) currents have been implicated in atrial and ventricular arrhythmogenesis and in setting the vascular tone. Furthermore, the association of genetic alterations in K(2P)3.1 channels with atrial fibrillation, cardiac conduction disorders and pulmonary arterial hypertension demonstrates the relevance of the channels in cardiovascular disease. The function, regulation and clinical significance of cardiovascular K(2P) channels are summarized in the present review, and therapeutic options are emphasized.

  13. Proof-of-concept demonstration of a miniaturized three-channel multiresolution imaging system

    NASA Astrophysics Data System (ADS)

    Belay, Gebirie Y.; Ottevaere, Heidi; Meuret, Youri; Vervaeke, Michael; Van Erps, Jürgen; Thienpont, Hugo

    2014-05-01

    Multichannel imaging systems have several potential applications such as multimedia, surveillance, medical imaging and machine vision, and have therefore been a hot research topic in recent years. Such imaging systems, inspired by natural compound eyes, have many channels, each covering only a portion of the total field-of-view of the system. As a result, these systems provide a wide field-of-view (FOV) while having a small volume and a low weight. Different approaches have been employed to realize a multichannel imaging system. We demonstrated that the different channels of the imaging system can be designed in such a way that they can have each different imaging properties (angular resolution, FOV, focal length). Using optical ray-tracing software (CODE V), we have designed a miniaturized multiresolution imaging system that contains three channels each consisting of four aspherical lens surfaces fabricated from PMMA material through ultra-precision diamond tooling. The first channel possesses the largest angular resolution (0.0096°) and narrowest FOV (7°), whereas the third channel has the widest FOV (80°) and the smallest angular resolution (0.078°). The second channel has intermediate properties. Such a multiresolution capability allows different image processing algorithms to be implemented on the different segments of an image sensor. This paper presents the experimental proof-of-concept demonstration of the imaging system using a commercial CMOS sensor and gives an in-depth analysis of the obtained results. Experimental images captured with the three channels are compared with the corresponding simulated images. The experimental MTF of the channels have also been calculated from the captured images of a slanted edge target test. This multichannel multiresolution approach opens the opportunity for low-cost compact imaging systems that can be equipped with smart imaging capabilities.

  14. Performance analysis of a LDPC coded OFDM communication system in shallow water acoustic channels

    NASA Astrophysics Data System (ADS)

    Liu, Shengxing; Xu, Xiaomei

    2012-11-01

    Time-varying significant multipath interference is the major obstacle to reliable data communication in shallow water acoustic channels. In this paper, the performance of a low density parity check (LDPC) coded orthogonal frequency division multiplexing (OFDM) communication system is investigated for these channels. The initial message for LDPC, decoded by using the belief propagation (BP) algorithm, is deduced for OFDM underwater acoustic channels; based on this deduction, the noise thresholds of regular LDPC codes with different code rates are obtained by using the density evolution algorithm. Furthermore, a communication system model, developed with LDPC code, OFDM and channel interleaver for shallow water acoustic channels, is introduced. The effect of modulation and coding schemes on the LDPC codes performance is investigated by simulation. The results show that the system can achieve remarkable performance in shallow water acoustic channels, and the performance improves with increasing code length and decreasing code rate. The bit error rate (BER) of the system, under conditions with QPSK modulation, 1280-code length and 1/2-code rate, is less than 10-5 when the signal to noise ratio (SNR) is greater than 6.8dB. These values are obtained for a five-path shallow water acoustic channel of Xiamen harbor.

  15. Low-mobility channel tracking for MIMO-OFDM communication systems

    NASA Astrophysics Data System (ADS)

    Pagadarai, Srikanth; Wyglinski, Alexander M.; Anderson, Christopher R.

    2013-12-01

    It is now well understood that by exploiting the available additional spatial dimensions, multiple-input multiple-output (MIMO) communication systems provide capacity gains, compared to a single-input single-output systems without increasing the overall transmit power or requiring additional bandwidth. However, these large capacity gains are feasible only when the perfect knowledge of the channel is available to the receiver. Consequently, when the channel knowledge is imperfect, as is common in practical settings, the impact of the achievable capacity needs to be evaluated. In this study, we begin with a general MIMO framework at the outset and specialize it to the case of orthogonal frequency division multiplexing (OFDM) systems by decoupling channel estimation from data detection. Cyclic-prefixed OFDM systems have attracted widespread interest due to several appealing characteristics not least of which is the fact that a single-tap frequency-domain equalizer per subcarrier is sufficient due to the circulant structure of the resulting channel matrix. We consider a low-mobility wireless channel which exhibits inter-block channel variations and apply Kalman tracking when MIMO-OFDM communication is performed. Furthermore, we consider the signal transmission to contain a stream of training and information symbols followed by information symbols alone. By relying on predicted channel states when training symbols are absent, we aim to understand how the improvements in channel capacity are affected by imperfect channel knowledge. We show that the Kalman recursion procedure can be simplified by the optimal minimum mean square error training design. Using the simplified recursion, we derive capacity upper and lower bounds to evaluate the performance of the system.

  16. Design of a communications system for multiple telemetry data channels operating simultaneously with a coherent turn-around ranging channel

    NASA Technical Reports Server (NTRS)

    Nguyen, Tien M.; Hinedi, Sami M.; Gevargiz, John M.

    1991-01-01

    This paper presents a simple technique to design a phase-modulated residual carrier communications link for optimum performance. The emphasis is on two data channels which are operated simultaneously with a ranging signal. The data channels employ PCM/PM and PCM/PSK/PM modulation schemes for high and low data rate channels, respectively. The technique proposed here selects the optimum (1) subcarrier frequency to minimize the interference between the two data channels, and (2) modulation indices for optimum balance of power between the two telemetry data channels and the coherent turn around ranging channel. The selected set of optimum modulation indices will allow for the specified bit error rate (BER) degradations in the two data channels. Although this technique is proposed to optimize the performance degradation for two data channels, generalizations can be made for more than two data channels.

  17. Integrated source and channel encoded digital communication system design study

    NASA Technical Reports Server (NTRS)

    Huth, G. K.; Udalov, S.

    1974-01-01

    This study investigated the configuration and integration of a wideband communication system with a Ku-band rendezvous radar system. The goal of the study was to provide as much commonality between the two systems as possible. The antenna design was described with the only change being the requirement for dual polarization (linear for the radar system and circular for the communication system).

  18. The channels of Mars

    NASA Technical Reports Server (NTRS)

    Baker, Victor R.

    1988-01-01

    The geomorphology of Mars is discussed, focusing on the Martian channels. The great flood channels of Mars, the processes of channel erosion, and dendritic channel networks, are examined. The topography of the Channeled Scabland region of the northwestern U.S. is described and compared to the Martian channels. The importance of water in the evolution of the channel systems is considered.

  19. CSI feedback-based CS for underwater acoustic adaptive modulation OFDM system with channel prediction

    NASA Astrophysics Data System (ADS)

    Kuai, Xiao-yan; Sun, Hai-xin; Qi, Jie; Cheng, En; Xu, Xiao-ka; Guo, Yu-hui; Chen, You-gan

    2014-06-01

    In this paper, we investigate the performance of adaptive modulation (AM) orthogonal frequency division multiplexing (OFDM) system in underwater acoustic (UWA) communications. The aim is to solve the problem of large feedback overhead for channel state information (CSI) in every subcarrier. A novel CSI feedback scheme is proposed based on the theory of compressed sensing (CS). We propose a feedback from the receiver that only feedback the sparse channel parameters. Additionally, prediction of the channel state is proposed every several symbols to realize the AM in practice. We describe a linear channel prediction algorithm which is used in adaptive transmission. This system has been tested in the real underwater acoustic channel. The linear channel prediction makes the AM transmission techniques more feasible for acoustic channel communications. The simulation and experiment show that significant improvements can be obtained both in bit error rate (BER) and throughput in the AM scheme compared with the fixed Quadrature Phase Shift Keying (QPSK) modulation scheme. Moreover, the performance with standard CS outperforms the Discrete Cosine Transform (DCT) method.

  20. Cloud and Aerosol Lidar Channel Design and Performance of the Geoscience Laser Altimeter System on the ICESat Mission

    NASA Technical Reports Server (NTRS)

    Sun, Xiaoli; Abshire, James B.; Krainak, Michael A.; Spinhirne, James D.; Palm, Steve S.; Lancaster, Redgie S.; Allan, Graham R.

    2004-01-01

    The design of the 532 and 1064nm wavelength atmosphere lidar channels of the Geoscience Laser Altimeter System on the ICESat spacecraft is described. The lidar channel performance per on orbit measurements data will be presented.

  1. Coupled-rearrangement-channels calculation of the three-body system under the absorbing boundary condition

    NASA Astrophysics Data System (ADS)

    Iwasaki, M.; Otani, R.; Ito, M.; Kamimura, M.

    2016-05-01

    We formulate the method of the absorbing boundary condition (ABC) in the coupled-rearrangement-channels variational method (CRCMV) for the three-body problem. In the present study, we handle the simple three-boson system, and the absorbing potential is introduced in the Jacobi coordinate in the individual rearrangement channels. The resonance parameters and the strength of the monopole breakup are compared with the complex scaling method (CSM). We have found that the CRCVM + ABC method nicely works in the threebody problem with the rearrangement channels.

  2. System design for a million channel digital spectrum analyzer /MCSA/. [of bandpass filtering in SETI receivers

    NASA Technical Reports Server (NTRS)

    Peterson, A.; Narasimha, M.; Narayan, S.

    1980-01-01

    The system design of a wideband (8 MHz) million-channel digital spectrum analyzer for use with a SETI receiver is presented. The analyzer makes use of a digital bandpass filter bank for transforming the wideband input signal into a specified number (120) of uniform narrowband output channels by the use of a Fourier transform digital processor combined with a prototype digital weighting network (finite impulse response filter). The output is then processed separately by 120 microprocessor-based discrete Fourier transform computers, each producing 8190 output channels of approximately 8 Hz bandwidth by the use of an 8190-point prime factor algorithm.

  3. RBF multiuser detector with channel estimation capability in a synchronous MC-CDMA system.

    PubMed

    Ko, K; Choi, S; Kang, C; Hong, D

    2001-01-01

    The authors propose a multiuser detector with channel estimation capability using a radial basis function (RBF) network in a synchronous multicarrier-code division multiple access (MC-CDMA) system. The authors propose to connect an RBF network to the frequency domain to effectively utilize the frequency diversity. Simulations were performed over frequency-selective and multi-path fading channels. These simulations confirmed that the proposed receiver can be used both for the channel estimation and as a multi-user receiver, thus permitting an increase in the number of active users. PMID:18249987

  4. Note: Experimental observation of nano-channel pattern in light sheet laser interference nanolithography system

    NASA Astrophysics Data System (ADS)

    Mohan, Kavya; Mondal, Partha Pratim

    2016-06-01

    We experimentally observed nano-channel-like pattern in a light-sheet based interference nanolithography system. The optical system created nano-channel-like patterned illumination. Coherent counter-propagating light sheets are made to interfere at and near geometrical focus along the propagation z-axis. This results in the formation of nano-channel-like pattern (of size ≈ 300 nm and inter-channel periodicity of ≈337.5 nm) inside the sample due to constructive and destructive interference. In addition, the technique has the ability to generate large area patterning using larger light-sheets. Exciting applications are in the broad field of nanotechnology (nano-electronics and nano-fluidics).

  5. The design and analysis of channel transmission communication system of XCTD profiler

    NASA Astrophysics Data System (ADS)

    Zheng, Yu; Wang, Xiao-Rui; Jin, Xiang-Yu; Song, Guo-Min; Shang, Ying-Sheng; Li, Hong-Zhi

    2016-10-01

    In this paper, a channel transmission communication system of expendable conductivity-temperature-depth is established in accordance to the operation characteristics of the transmission line to more accurately assess the characteristics of deep-sea abandoned profiler channel. The wrapping inductance is eliminated to maximum extent through the wrapping pattern of the underwater spool and the overwater spool and the calculation of the wrapping diameter. The feasibility of the proposed channel transmission communication system is verified through theoretical analysis and practical measurement of the transmission signal error rate in the amplitude shift keying (ASK) modulation. The proposed design provides a new research method for the channel assessment of complex abandoned measuring instrument and an important experiment evidence for the rapid development of the deep-sea abandoned measuring instrument.

  6. Linkages between sediment supply and channel morphology in gravel-bed river systems

    NASA Astrophysics Data System (ADS)

    Pitlick, John; Recking, Alain; Liebault, Fred

    2013-04-01

    Mountain river systems are characterized by a wide range of channel patterns and varying levels of instability. In steeper channels- torrents and cascades- resistant bed and bank materials tend to limit entrainment and transport, except during large floods or debris flows. In lower-gradient channels, with meandering or braided planforms, bed and bank materials are mobilized more frequently, consequently channel geometry is maintained by a long-term balance between bank erosion and the lateral migration and growth of bars. These differences in stability are largely a reflection of position with the drainage network, but other factors, such as valley confinement and drainage basin sediment supply (both quantity and grain size), play equally strong roles in the downstream evolution of channel morphology. In this talk we present data and preliminary results from a comparative study of the influences of sediment supply on channel morphology in rivers draining high-elevation basins in the Rocky Mountains and the French Alps. Study sites are located in river basins with high to very high relief (1000-3000 m), and hydrologic cycles dominated by snowmelt runoff. The scaling between peak flows and drainage basin area is very similar in both regions. There are sharp contrasts, however, in the underlying rock types, and the connectivity between hillslopes and channels, such that the sediment supply to rivers in high-relief areas of the French Alps is orders of magnitude higher than in the Rocky Mountain region. Rock type also influences the grain size and durability of the sediment delivered from hillslopes, thus sand and fine gravel are abundant in French alpine channels. The net effect of finer grain sizes in channels with steep slopes is to produce Shields numbers that are 2-3 times the threshold for motion at channel-forming discharges. These conditions are quite different from conditions in Rocky Mountain channels where the Shields numbers at bankfull flows are typically

  7. The multi-channel laser focusing transceiver system and analysis of the image quality

    NASA Astrophysics Data System (ADS)

    Sui, Xin; Sun, Hongri; Yang, Kun; Qu, Zhou; Zhang, Bo; Cui, Yihan

    2015-10-01

    This paper has investigated and designed a multi-channel laser focusing transceiver system based on the combination of the laser technology, the space technology and the modern photoelectric detection technology which has the feather of wide wave band, non-chromatic aberration and high quality of image quality etc. The system could be synchronized and can change the distance of detection in a particular direction and obtain the image of atmospheric echo signals at different distances. In this paper we established a multi-channel and variable range laser focusing transceiver system that consists of a single-channel laser focusing transmitter system and a dual-channel receiving telescope system. The three channels of the system depend on the same reference axis. We propose a new method that is capable to improve the laser focusing transceiver system performance. The method is implemented by using parabolic reflector design in the primary and secondary mirror of the variable range laser focusing transmitter system, dual-channel off-axis design in the receiver system and simultaneous imaging design in the different regions of the same CCD target surface of the subsequent imaging system. The detection by two channels using off-axis design would be convenient for computing follow up information. On the base of theoretical basis of the reflective double mirror system and the theory Gaussian beam propagation, this paper calculates the actual converging sot size of the transmitter system and analyzes the wavefront aberration the defocus incidence. The oblique incidence will introduce the certain astigmatism and a small amount of coma and the defocus incidence will produce the certain coma and a small amount of spherical aberration and astigmatism. Finally, an experimental multi-channel laser focusing transceiver system was established and the image quality of the transceiver system on the base of wavefront aberrations, the spot diagram and the MTF curve of some fields is

  8. Towards a multi-channel TOF-PET system with SiPM readout

    NASA Astrophysics Data System (ADS)

    Garutti, Erika; Göttlich, Martin; Harion, Tobias; Hegemann, Niklas; Schmidt, Maximilian; Schultz-Coulon, Hans-Christian; Shen, Wei; Silenzi, Alessandro; Stamen, Rainer; Tadday, Alexander; Xu, Chen

    2012-12-01

    The goal of this project is to develop a multi-channel TOF-PET system with a 300 ps FWHM time resolution, a factor two improvement with respect to commercially available systems (Surti et al., 2007 [1]). In a TOF-PET system, the time-of-flight information can be used to improve significantly the sensitivity of the detector as shown in Karp et al. (2008) [2]. The target time resolution has been achieved in two channel systems with LYSO (Kim and Wang, 2008 [3]), the aim is to port this results into a multi-channel system. This work extends the results shown in Göttlich et al. (2010) [4], studying the stability of the detector performance in different geometries and configurations.

  9. Channel direction information probing for multi-antenna cognitive radio system

    NASA Astrophysics Data System (ADS)

    Yuan, Fang; Villardi, Gabriel Porto; Kojima, Fumihide; Yano, Hiroyuki

    2015-12-01

    This work studies the problem of channel direction information (CDI) probing for multi-antenna cognitive radio system. The CDI of the channel from the secondary transmitter (ST) to primary receiver (PR) is elementary information in designing the beamforming at the ST for mitigating the interference to the PR. However, lacking the explicit cooperation between primary and secondary systems, the CDI has to be acquired by probing at the ST, which is challenging. To solve this, we consider the line of sight (LoS) channel between the ST and the PR, and propose one CDI probing scheme for the ST. Specifically, the ST sends two types of probing signals by beamforming towards an interested region where both the secondary receiver (SR) and the PR are located and then actively learns the hidden feedback information from the primary system to acquire the CDI. The proposed scheme has a closed-form solution, and avoids the iteration between the probing and acquisition, which is desirable for practical system. Moreover, we show that the proposed probing scheme can be extended for primary systems working under multi-access channel and broadcasting channel. Simulation results demonstrate that the proposed scheme can improve the accuracy of the acquired CDI at the ST in cognitive ratio system remarkably.

  10. Water and sediment transport of channel-flat systems in a mesotidal mudflat: Willapa Bay, Washington

    NASA Astrophysics Data System (ADS)

    Nowacki, Daniel J.; Ogston, Andrea S.

    2013-06-01

    The muddy tidal flats of southern Willapa Bay, Washington are tidally dominated and receive little direct freshwater input. We use data from instruments deployed in channels of different size and on their adjacent flats to investigate the hydrodynamics and sediment dynamics of each morphological setting under a range of seasonal and meteorological conditions, including rain and wind events. Interaction between the morphology of the channel/flat complex and tidal water-level variations produces well-defined velocity pulses during both flooding and ebbing tides. These pulses represent about 27% of the total along-channel water transport and 35% of the suspended-sediment transport of the system. Maintenance of continuity produces the velocity pulse, and pulse magnitude is determined by tidal range. Wind alters the flow regime in channels and on the flat, enhancing over-flat ebb flow in this study location while decreasing ebb-pulse intensity. Wind speed was positively correlated with minimum suspended-sediment concentration. Precipitation falling directly on flats was found to erode flat sediment, which subsequently formed a temporary deposit in the adjacent channel. Residual along-channel water transport in channels and on nearby flats was flood dominant under all seasonal conditions sampled, and sediment flux was flood dominant during winter and spring deployments.

  11. Integrated source and channel encoded digital communication system design study

    NASA Technical Reports Server (NTRS)

    Alem, W. K.; Huth, G. K.; Simon, M. K.

    1978-01-01

    The particular Ku-band carrier, PN despreading, and symbol synchronization strategies, which were selected for implementation in the Ku-band transponder aboard the orbiter, were assessed and evaluated from a systems performance viewpoint, verifying that system specifications were met. A study was performed of the design and implementation of tracking techniques which are suitable for incorporation into the Orbiter Ku-band communication system. Emphasis was placed on maximizing tracking accuracy and communication system flexibility while minimizing cost, weight, and system complexity of Orbiter and ground systems hardware. The payload communication study assessed the design and performance of the forward link and return link bent-pipe relay modes for attached and detached payloads. As part of this study, a design for a forward link bent-pipe was proposed which employs a residual carrier but which is tracked by the existing Costas loop.

  12. High-resolution pluronic-filled microchip CE-SSCP analysis system via channel width control.

    PubMed

    Shin, Giyoung; Kim, Dong-Kyun; Doh, Junsang; Lee, Daeyeon; Lee, Nam Ki; Jung, Gyoo Yeol

    2016-02-01

    Although the resolution of CE-SSCP has been significantly improved by using a poly(ethyleneoxide)-poly(propyleneoxide)-poly(ethyleneoxide) (PEO-PPO-PEO; Pluronic(®)) triblock copolymer as a separation medium, CE-SSCP on a microchip format is not widely applicable because their resolution is limited by short channel length. Therefore, a strategy to improve the resolution in channels of limited lengths is highly required for enabling microchip-based CE-SSCP. In this study, we developed a high-resolution CE-SSCP microchip system by controlling the width of the pluronic-filled channel. We tested four different channel widths of 180, 240, 300, and 400 μm, and found that 300 μm showed the highest resolution in the separation of two pathogen specific markers. Potential applications of our method in various genetic analyses were also shown by using SNP markers for spinal muscular atrophy. PMID:26542319

  13. Channel estimation for OFDM system in atmospheric optical communication based on compressive sensing

    NASA Astrophysics Data System (ADS)

    Zhao, Qingsong; Hao, Shiqi; Geng, Hongjian; Sun, Han

    2015-10-01

    Orthogonal frequency division multiplexing (OFDM) technique applied to the atmospheric optical communication can improve data transmission rate, restrain pulse interference, and reduce effect of multipath caused by atmospheric scattering. Channel estimation, as one of the important modules in OFDM, has been investigated thoroughly and widely with great progress. In atmospheric optical communication system, channel estimation methods based on pilot are common approaches, such as traditional least-squares (LS) algorithm and minimum mean square error (MMSE) algorithm. However, sensitivity of the noise effects and high complexity of computation are shortcomings of LS algorithm and MMSE algorithm, respectively. Here, a new method based on compressive sensing is proposed to estimate the channel state information of atmospheric optical communication OFDM system, especially when the condition is closely associated with turbulence. Firstly, time-varying channel model is established under the condition of turbulence. Then, in consideration of multipath effect, sparse channel model is available for compressive sensing. And, the pilot signal is reconstructed with orthogonal matching tracking (OMP) algorithm, which is used for reconstruction. By contrast, the work of channel estimation is completed by LS algorithm as well. After that, simulations are conducted respectively in two different indexes -signal error rate (SER) and mean square error (MSE). Finally, result shows that compared with LS algorithm, the application of compressive sensing can improve the performance of SER and MSE. Theoretical analysis and simulation results show that the proposed method is reasonable and efficient.

  14. TRPM4 channels in the cardiovascular system: physiology, pathophysiology, and pharmacology.

    PubMed

    Abriel, Hugues; Syam, Ninda; Sottas, Valentin; Amarouch, Mohamed Yassine; Rougier, Jean-Sébastien

    2012-10-01

    The transient receptor potential channel (TRP) family comprises at least 28 genes in the human genome. These channels are widely expressed in many different tissues, including those of the cardiovascular system. The transient receptor potential channel melastatin 4 (TRPM4) is a Ca(2+)-activated non-specific cationic channel, which is impermeable to Ca(2+). TRPM4 is expressed in many cells of the cardiovascular system, such as cardiac cells of the conduction pathway and arterial and venous smooth muscle cells. This review article summarizes the recently described roles of TRPM4 in normal physiology and in various disease states. Genetic variants in the human gene TRPM4 have been linked to several cardiac conduction disorders. TRPM4 has also been proposed to play a crucial role in secondary hemorrhage following spinal cord injuries. Spontaneously hypertensive rats with cardiac hypertrophy were shown to over-express the cardiac TRPM4 channel. Recent studies suggest that TRPM4 plays an important role in cardiovascular physiology and disease, even if most of the molecular and cellular mechanisms have yet to be elucidated. We conclude this review article with a brief overview of the compounds that have been shown to either inhibit or activate TRPM4 under experimental conditions. Based on recent findings, the TRPM4 channel can be proposed as a future target for the pharmacological treatment of cardiovascular disorders, such as hypertension and cardiac arrhythmias.

  15. Solids management in a channel catfish biofloc technology production system

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Biofloc technology (BFT) production systems are being used more commonly to produce high yields of fish or shrimp because very high feed rates are possible. In an outdoor BFT production system, a complex of living organisms is closely associated with particulate organic matter and is maintained in s...

  16. Multiple channel secure communication using chaotic system encoding

    SciTech Connect

    Miller, S.L.

    1996-12-31

    fA new method to encrypt signals using chaotic systems has been developed that offers benefits over conventional chaotic encryption methods. The method simultaneously encodes multiple plaintext streams using a chaotic system; a key is required to extract the plaintext from the chaotic cipertext. A working prototype demonstrates feasibility of the method by simultaneously encoding and decoding multiple audio signals using electrical circuits.

  17. Growing stocker channel catfish in a biofloc technology production system

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Biofloc technology (BFT), or mixed suspended-growth, production systems are being used more frequently worldwide for culturing various aquatic animals because of the high yields that are possible. In an outdoor BFT production system, a complex of living organisms is closely associated with particula...

  18. Long-term morphological response to dredging including cut-across-shoal in a tidal channel-shoal system

    NASA Astrophysics Data System (ADS)

    Wang, Yu-Hai; Wang, Chong-Hao; Tang, Li-Qun; Liu, Da-Bin; Guo, Chuan-Sheng; Liu, Chun-Jing; Zhao, Hui-Ming

    2014-12-01

    This study examines long-term channel-shoal stability in the Tieshan Bay, which is located on the southwest coast of China. A large-scale channel-shoal system has historically existed in the outer Tieshan Bay. A navigation waterway is initiated by cutting and dredging a mid-channel shoal to supply coal to a power plant on the middle coast of the Tieshan Bay. Dredging of the access channel to the Tieshan Port was conducted in two stages followed by land reclamation. It is thus of practical meaning to explore how the channel-shoal system will evolve in long term afterwards. This study uses the process-based finite-volume coastal ocean model (FVCOM) to investigate long-term (centennial) morphological evolution of the channel-shoal system. After well calibration of hydrodynamics and sediment transport, the model forecasts morphodynamic evolution in hundred years. The simulations show that continuous erosion in tidal channels and accretion over shoals and intertidal flats occur. However, the cutting and access channels will be subjected to long-term siltation. A secondary channel indicating the reorientation of the access channel will emerge, and a localized channel-ridge system at the junction of the major channels will be formed. The overall erosion/accretion pattern demonstrates the combined effect of bottom friction and advective sediment transport processes to be responsible for the channel-shoal formation. Dredging of the tidal channels will stimulate the stability of the channel-shoal pattern. It suggests that the navigation waterway should be set up following the long-term morphological evolution of the channel-shoal system at a design stage and maintenance dredging volume might thus be minimized.

  19. A bidirection-adjustable ionic current rectification system based on a biconical micro-channel.

    PubMed

    Chang, Fengxia; Chen, Cheng; Xie, Xia; Chen, Lisha; Li, Meixian; Zhu, Zhiwei

    2015-10-25

    We developed a simple, cheap and bidirectional ionic current rectification system based on the integration of a biconical micro-channel, working electrode and reference electrode. This system may have potential and realistic future value for studying two-way ionic transport in the cell membrane. PMID:26339989

  20. Winter performance of an outdoor biofloc production system for channel catfish

    Technology Transfer Automated Retrieval System (TEKTRAN)

    In the tropics, outdoor biofloc technology production systems are operated year-round. While channel catfish (Ictalurus punctatus) have been grown successfully in an outdoor biofloc production system, these studies were conducted only during the growing season and production tanks were idled for the...

  1. Combined medical diagnostic system with separated laser-Doppler and reflectance oximeter channels

    NASA Astrophysics Data System (ADS)

    Amzina, M. V.; Micheev, A. A.; Rogatkin, D. A.; Sidorov, V. V.

    2006-08-01

    On the basis of studying of opportunities of Reflectance Tissues Oximetry (RTO) as well as on the basis of RTO and Laser Doppler Flowmetry (LDF) comparative data, received in Moscow Regional Research and Clinical Institute "MONIKI" while patients with the peripheral blood microcirculation disorders were under examination, it was offered to unite the RTO and LDF techniques in a single diagnostic system. The new two-channel diagnostic system will contain the first LDF channel to measure the blood microcirculation parameters and the second RTO channel to register an average peripheral blood oxygenation. In the report the features of the new system design and a number of experimental data on correlation of RTO and LDF results are considered. The prospects of amalgamation of these two different techniques in a single diagnostic device are shown as well.

  2. Extended Horizon Liftings for Periodic Gain Adjustments in Control Systems, and for Equalization of Communication Channels

    NASA Technical Reports Server (NTRS)

    Bayard, David S. (Inventor)

    1996-01-01

    Periodic gain adjustment in plants of irreducible order, n, or for equalization of communications channels is effected in such a way that the plant (system) appears to be minimum phase by choosing a horizon time N greater then n of liftings in periodic input and output windows Pu and Py, respectively, where N is an integer chosen to define the extent (length) of each of the windows Pu and Py, and n is the order of an irreducible input/output plant. The plant may be an electrical, mechanical or chemical system, in which case output tracking (OT) is carried out for feedback control or a communication channel, in which case input tracking (IT) is carried out. Conditions for OT are distinct from IT in terms of zero annihilation, namely for OT and of IT, where the OT conditions are intended for gain adjustments in the control system, and IT conditions are intended for equalization for communication channels.

  3. Comparison of Single Channel Potassium Current in Biological and Synthetic Systems --- Dependence on Voltage

    NASA Astrophysics Data System (ADS)

    Siwy, Zuzanna; Mercik, Szymon; Weron, Karina; Spohr, Reimar; Wolf, Alexander; Grzywna, Zbigniew

    2000-05-01

    The influence of an external field on an ion current pattern in biological and synthetic systems was investigated. The patch clamp recordings of potassium current through a big conductance locust potassium channel (BK-channel) and a track-etched polyethylene terephthalate membrane were examined by the power spectrum, fractal analysis and relative dispersion analysis. A similar dependence of potassium current behaviour on the external voltage in both systems was found. The generalized dimension formalism is redefined to make it applicable to the analysis of time series.

  4. Single layer, multi-channel band-gear system for rotary joint

    NASA Technical Reports Server (NTRS)

    Kong, Kin Yuen (Inventor)

    1998-01-01

    A multi-channel band-gear system for a rotary joint has a ring gear assembly with a conducting ring band in electrical contact with corresponding conducting bands of a set of intermediary planetary gears, which in turn are in electrical contact with a conducting sun band of a sun gear assembly. The ring band is formed with a plurality of conducting segments which are electrically insulated from each other and positioned angularly in a circumferential direction of the ring gear, such that separate electrical power/signal channels are formed across the rotary joint. In a preferred embodiment having continuously connected channels, the ring band has four conducting segments at 90.degree. intervals, the sun band has two conducting segments at 180.degree. intervals, and three planetary bands are in rolling electrical contact at 120.degree. intervals between the ring band segments and the sun band segments, forming two continuously connected channels in a single layer of the band-gear system. Multiple sets of ring gear, planetary gear, and sun gear assemblies may be used in a stacked configuration in a single axial layer to further increase the number of channels provided through the band-gear system.

  5. Channel Equalization and Phase Estimation for Reduced-Guard-Interval CO-OFDM Systems

    NASA Astrophysics Data System (ADS)

    Zhuge, Qunbi

    Reduced-guard-interval (RGI) coherent optical (CO) orthogonal frequency-division multiplexing (OFDM) is a potential candidate for next generation 100G beyond optical transports, attributed to its advantages such as high spectral efficiency and high tolerance to optical channel impairments. First of all, we review the coherent optical systems with an emphasis on CO-OFDM systems as well as the optical channel impairments and the general digital signal processing techniques to combat them. This work focuses on the channel equalization and phase estimation of RGI CO-OFDM systems. We first propose a novel equalization scheme based on the equalization structure of RGI CO-OFDM to reduce the cyclic prefix overhead to zero. Then we show that intra-channel nonlinearities should be considered when designing the training symbols for channel estimation. Afterwards, we propose and analyze the phenomenon of dispersion-enhanced phase noise (DEPN) caused by the interaction between the laser phase noise and the chromatic dispersion in RGI CO-OFDM transmissions. DEPN induces a non-negligible performance degradation and limits the tolerant laser linewidth. However, it can be compensated by the grouped maximum-likelihood phase estimation proposed in this work.

  6. Indoor positioning system using WLAN channel estimates as fingerprints for mobile devices

    NASA Astrophysics Data System (ADS)

    Schmidt, Erick; Akopian, David

    2015-03-01

    With the growing integration of location based services (LBS) such as GPS in mobile devices, indoor position systems (IPS) have become an important role for research. There are several IPS methods such as AOA, TOA, TDOA, which use trilateration for indoor location estimation but are generally based on line-of-sight. Other methods rely on classification such as fingerprinting which uses WLAN indoor signals. This paper re-examines the classical WLAN fingerprinting accuracy which uses received signal strength (RSS) measurements by introducing channel estimates for improvements in the classification of indoor locations. The purpose of this paper is to improve existing classification algorithms used in fingerprinting by introducing channel estimates when there are a low number of APs available. The channel impulse response, or in this case the channel estimation from the receiver, should characterize a complex indoor area which usually has multipath, thus providing a unique signature for each location which proves useful for better pattern recognition. In this experiment, channel estimates are extracted from a Software-Defined Radio (SDR) environment, thus exploiting the benefits of SDR from a NI-USRP model and LabVIEW software. Measurements are taken from a known building, and several scenarios with one and two access points (APs) are used in this experiment. Also, three granularities in distance between locations are analyzed. A Support Vector Machine (SVM) is used as the algorithm for pattern recognition of different locations based on the samples taken from RSS and channel estimation coefficients.

  7. Development of a 64 channel ultrasonic high frequency linear array imaging system

    PubMed Central

    Hu, ChangHong; Zhang, Lequan; Cannata, Jonathan M.; Yen, Jesse; Shung, K. Kirk

    2011-01-01

    In order to improve the lateral resolution and extend the field of view of a previously reported 48 element 30 MHz ultrasound linear array and 16-channel digital imaging system, the development of a 256 element 30 MHz linear array and an ultrasound imaging system with increased channel count has been undertaken. This paper reports the design and testing of a 64 channel digital imaging system which consists of an analog front-end pulser/receiver, 64 channels of Time-Gain Compensation (TGC), 64 channels of high-speed digitizer as well as a beamformer. A Personal Computer (PC) is used as the user interface to display real-time images. This system is designed as a platform for the purpose of testing the performance of high frequency linear arrays that have been developed in house. Therefore conventional approaches were taken it its implementation. Flexibility and ease of use are of primary concern whereas consideration of cost-effectiveness and novelty in design are only secondary. Even so, there are many issues at higher frequencies but do not exist at lower frequencies need to be solved. The system provides 64 channels of excitation pulsers while receiving simultaneously at a 20 MHz–120 MHz sampling rate to 12-bits. The digitized data from all channels are first fed through Field Programmable Gate Arrays (FPGAs), and then stored in memories. These raw data are accessed by the beamforming processor to re-build the image or to be downloaded to the PC for further processing. The beamformer that applies delays to the echoes of each channel is implemented with the strategy that combines coarse (8.3ns) and fine delays (2 ns). The coarse delays are integer multiples of the sampling clock rate and are achieved by controlling the write enable pin of the First-In-First-Out (FIFO) memory to obtain valid beamforming data. The fine delays are accomplished with interpolation filters. This system is capable of achieving a maximum frame rate of 50 frames per second. Wire phantom

  8. Development of a 64 channel ultrasonic high frequency linear array imaging system.

    PubMed

    Hu, ChangHong; Zhang, Lequan; Cannata, Jonathan M; Yen, Jesse; Shung, K Kirk

    2011-12-01

    In order to improve the lateral resolution and extend the field of view of a previously reported 48 element 30 MHz ultrasound linear array and 16-channel digital imaging system, the development of a 256 element 30 MHz linear array and an ultrasound imaging system with increased channel count has been undertaken. This paper reports the design and testing of a 64 channel digital imaging system which consists of an analog front-end pulser/receiver, 64 channels of Time-Gain Compensation (TGC), 64 channels of high-speed digitizer as well as a beamformer. A Personal Computer (PC) is used as the user interface to display real-time images. This system is designed as a platform for the purpose of testing the performance of high frequency linear arrays that have been developed in house. Therefore conventional approaches were taken it its implementation. Flexibility and ease of use are of primary concern whereas consideration of cost-effectiveness and novelty in design are only secondary. Even so, there are many issues at higher frequencies but do not exist at lower frequencies need to be solved. The system provides 64 channels of excitation pulsers while receiving simultaneously at a 20-120 MHz sampling rate to 12-bits. The digitized data from all channels are first fed through Field Programmable Gate Arrays (FPGAs), and then stored in memories. These raw data are accessed by the beamforming processor to re-build the image or to be downloaded to the PC for further processing. The beamformer that applies delays to the echoes of each channel is implemented with the strategy that combines coarse (8.3 ns) and fine delays (2 ns). The coarse delays are integer multiples of the sampling clock rate and are achieved by controlling the write enable pin of the First-In-First-Out (FIFO) memory to obtain valid beamforming data. The fine delays are accomplished with interpolation filters. This system is capable of achieving a maximum frame rate of 50 frames per second. Wire phantom images

  9. Multi-channel data acquisition system with absolute time synchronization

    NASA Astrophysics Data System (ADS)

    Włodarczyk, Przemysław; Pustelny, Szymon; Budker, Dmitry; Lipiński, Marcin

    2014-11-01

    We present a low-cost, stand-alone global-time-synchronized data acquisition system. Our prototype allows recording up to four analog signals with a 16-bit resolution in variable ranges and a maximum sampling rate of 1000 S/s. The system simultaneously acquires readouts of external sensors e.g. magnetometer or thermometer. A complete data set, including a header containing timestamp, is stored on a Secure Digital (SD) card or transmitted to a computer using Universal Serial Bus (USB). The estimated time accuracy of the data acquisition is better than ±200 ns. The device is intended for use in a global network of optical magnetometers (the Global Network of Optical Magnetometers for Exotic physics - GNOME), which aims to search for signals heralding physics beyond the Standard Model, that can be generated by ordinary spin coupling to exotic particles or anomalous spin interactions.

  10. Polarization Drift Channel Model for Coherent Fibre-Optic Systems.

    PubMed

    Czegledi, Cristian B; Karlsson, Magnus; Agrell, Erik; Johannisson, Pontus

    2016-01-01

    A theoretical framework is introduced to model the dynamical changes of the state of polarization during transmission in coherent fibre-optic systems. The model generalizes the one-dimensional phase noise random walk to higher dimensions, accounting for random polarization drifts, emulating a random walk on the Poincaré sphere, which has been successfully verified using experimental data. The model is described in the Jones, Stokes and real four-dimensional formalisms, and the mapping between them is derived. Such a model will be increasingly important in simulating and optimizing future systems, where polarization-multiplexed transmission and sophisticated digital signal processing will be natural parts. The proposed polarization drift model is the first of its kind as prior work either models polarization drift as a deterministic process or focuses on polarization-mode dispersion in systems where the state of polarization does not affect the receiver performance. We expect the model to be useful in a wide-range of photonics applications where stochastic polarization fluctuation is an issue. PMID:26905596

  11. Polarization Drift Channel Model for Coherent Fibre-Optic Systems

    PubMed Central

    Czegledi, Cristian B.; Karlsson, Magnus; Agrell, Erik; Johannisson, Pontus

    2016-01-01

    A theoretical framework is introduced to model the dynamical changes of the state of polarization during transmission in coherent fibre-optic systems. The model generalizes the one-dimensional phase noise random walk to higher dimensions, accounting for random polarization drifts, emulating a random walk on the Poincaré sphere, which has been successfully verified using experimental data. The model is described in the Jones, Stokes and real four-dimensional formalisms, and the mapping between them is derived. Such a model will be increasingly important in simulating and optimizing future systems, where polarization-multiplexed transmission and sophisticated digital signal processing will be natural parts. The proposed polarization drift model is the first of its kind as prior work either models polarization drift as a deterministic process or focuses on polarization-mode dispersion in systems where the state of polarization does not affect the receiver performance. We expect the model to be useful in a wide-range of photonics applications where stochastic polarization fluctuation is an issue. PMID:26905596

  12. Pairwise Quantum Discord for a Symmetric Multi-Qubit System in Different Types of Noisy Channels

    NASA Astrophysics Data System (ADS)

    Guo, You-Neng; Zeng, Ke; Wang, Guo-You

    2016-06-01

    We study the pairwise quantum discord (QD) for a symmetric multi-qubit system in different types of noisy channels, such as phase-flip, amplitude damping, phase-damping, and depolarizing channels. Using the QD and geometric quantum discord (GMQD) to quantify quantum correlations, some analytical and numerical results are presented. The results show that, the QD dynamics is strongly related to the number of spin particles N as well as the initial parameter 𝜃 of the one-axis twisting collective state. With the number of spin particles N increasing, the amount of the QD increases. However, when the amount of the QD arrives at a stable maximal value, the QD is independence of the number of spin particles N increasing. The behavior of the QD is symmetrical during a period 0 ≤ 𝜃 ≤ 2 π. Moreover, we compare the QD dynamics with the GMQD for a symmetric multi-qubit system in different types of noisy channels.

  13. Channel correlation of transmit diversity FSO systems with partially coherent optical beams

    NASA Astrophysics Data System (ADS)

    Wang, Xiaoyang; Yao, Mingwu; Yi, Xiang; Liu, Zengji; Qiu, Zhiliang

    2015-01-01

    Spatial diversity, including transmit diversity, has been proven to be a promising technique to mitigate turbulence-induced signal fading. However, due to the limitation of size in compact FSO (free-space optical) terminals, the transmit antennas cannot always be separated far enough from each other, resulting in increased channel correlation and deteriorated diversity performance. In this paper, we focus on the channel correlation statistics of transmit diversity FSO systems with two transmit beams. Specifically, we consider partially coherent optical beams, which reduce scintillation over fully coherent optical beams. We perform theoretical analysis and obtain some interesting numerical results, such as the degree of channel correlation which changed mainly with source correlation radius from 0.001 to 0.1 m. These results can be helpful for designing transmit diversity FSO systems with partially coherent beams.

  14. Deltas as Ecomorphodynamic Systems: Effects of Vegetation Gradients on Sediment Trapping and Channel Dynamics

    NASA Astrophysics Data System (ADS)

    Piliouras, A.; Kim, W.; Goggin, H.

    2014-12-01

    Understanding the feedbacks between water, sediment, and vegetation in deltas is an important part of understanding deltas as ecomorphodynamic systems. We conducted a set of laboratory experiments using alfalfa (Medicago sativa) as a proxy for delta vegetation to determine (1) the effects of plants on delta growth and channel dynamics and (2) the influence of fine material on delta evolution. Vegetated experiments were compared to a control run without plants to isolate the effects of vegetation, and experiments with fine sediment were compared to a set of similar experiments with only sand. We found that alfalfa increased sediment trapping on the delta topset, and that the plants were especially effective at retaining fine material. Compared to the control run, the vegetated experiments showed an increased retention of fine sediment on the floodplain that resulted in increased delta relief and stronger pulses of shoreline progradation when channel avulsion and migration occurred. In other words, a higher amount of sediment storage with the addition of vegetation corresponded to a higher amount of sediment excavation during channelization events. In natural systems, dense bank vegetation is typically expected to help confine flow. We seeded our delta uniformly, which eliminated typical vegetation density gradients from riverbank to island center and therefore diminished the gradient in overbank sedimentation that best confines channels by creating levees. Dense clusters of alfalfa throughout the interior of the floodplain and delta islands were therefore able to induce flow splitting, where channels diverged around a stand of plants. This created several smaller channels that were then able to more widely distribute sediment at the delta front compared to unvegetated experiments. We conclude that plants are efficient sediment trappers that change the rate and amount of sediment storage in the delta topset, and that gradients in vegetation density are an important

  15. An introduction to wideband, two-channel direction-finding systems. I - General system overview, radiator, and arithmetic subsystems

    NASA Astrophysics Data System (ADS)

    Mosko, J. A.

    1984-02-01

    It is pointed out that two-channel monopulse direction-finding (DF) systems have been used for many years in such antiradiation homing (ARH) missiles as Shrike and Standard ARM. The present investigation is concerned with the fairly broad topic of two-channel monopulse DF techniques. The entire system is considered in a system overview, and the design of multifilament spirals, with emphasis on dual-mode four-arm spirals, is discussed. Attention is given to radiation impedances and reference surface rotation, the hyperbolic spiral antenna, polarization diversity multimode antennas, and arithmetic subsystems.

  16. A Four Channel Beam Current Monitor Data Acquisition System Using Embedded Processors

    SciTech Connect

    Wheat, Jr., Robert Mitchell; Dalmas, Dale A.; Dale, Gregory E.

    2015-08-11

    Data acquisition from multiple beam current monitors is required for electron accelerator production of Mo-99. A two channel system capable of recording data from two beam current monitors has been developed, is currently in use, and is discussed below. The development of a cost-effective method of extending this system to more than two channels and integrating of these measurements into an accelerator control system is the main focus of this report. Data from these current monitors is digitized, processed, and stored by a digital data acquisition system. Limitations and drawbacks with the currently deployed digital data acquisition system have been identified as have been potential solutions, or at least improvements, to these problems. This report will discuss and document the efforts we've made in improving the flexibility and lowering the cost of the data acquisition system while maintaining the minimum requirements.

  17. Characteristics of weakly confined submarine channel system and their application to gas hydrate trapping system, Eastern Nankai Trough, Japan

    NASA Astrophysics Data System (ADS)

    Komatsu, Y.; Fujii, T.; Suzuki, K.

    2013-12-01

    The 1st offshore gas hydrate production test was conducted at gas hydrate concentrated zone (reservoir) of the Eastern Nankai Trough, which is considered stratigraphic accumulation. However, the accumulation mechanism for this concentrated zone is not yet well understood. In this study, in order to examine gas hydrate trapping system in the accumulation mechanism, we identify the depositional process and controlling factors based on facies analysis and sequence stratigraphy using the core and geophysical log data. Our study area is the minibasin in the front of the north slope of Daini-Atsumi Knoll in the Eastern Nankai Trough. The minibasin development is strongly influenced by uplift of the knoll associated with plate subduction. The minibasin fill deposits are interpreted as the Pleistocene trough fill small turbidite fan system. Seven depositional sequences are identified based on grain size, bed thickness, sedimentary structure, and stacking pattern in this study. The sequence boundaries are also identified by terminations of seismic reflection. These sequences are attributed to a fourth to fifth-order eustatic sea-level changes, because the stacking pattern cycle is in phase with global oxygen isotope curves, the cycle is also identified in the onshore formation during the same period. The reservoir was interpreted as Falling-Stage Systems Tract (FSST) and Lowstand Systems Tract (LST). In the reservoir, it was observed the channel complex set characterized by relatively strong reflections and paleocurrent flowing from northeast to southwest on 3-D seismic data. The channel complex set changes into muddy facies in the south direction. The channel complex set is characterized by hemipelagic setting or slope (F1), abandonment mud drape (F2), nonamalgamated channel element (F3), and semiamalgamated channel element (F4). The channel elements (F3, 4) are the fundamental unit and record a single phase of downcutting and filling. The building block of the channel

  18. Design of a robust underwater acoustic communication system over multipath fading channels

    NASA Astrophysics Data System (ADS)

    Kim, Jangeun; Shim, Taebo

    2012-11-01

    Due to the surface and bottom constraints of the underwater acoustic channel (UAC) in shallow waters, multipath fading occurs and causes degradation of the signal for the UAC system. To overcome these problems, a robust underwater acoustic communication system was designed over multipath fading channels by employing both decision feedback equalization with the RLS algorithm and convolutional coding with interleaving+shuffling block data sequence. The dual use of these two methods simultaneously can reduce the intersymbol interference (ISI) and the adjacent bit and burst errors. The system will retransmit the same signal if the system fails to estimate the channel due to severe multipath fading. To verify the performance of the system, the transmission of an image was tested using a 524,288bit gray-scaled image through the multipath fading channel. The test results showed that the number of bit errors was reduced from 86,824 to 5,106 when the reference SNR was 12 dB.

  19. Integrated source and channel encoded digital communication system design study. [for space shuttles

    NASA Technical Reports Server (NTRS)

    Huth, G. K.

    1976-01-01

    The results of several studies Space Shuttle communication system are summarized. These tasks can be divided into the following categories: (1) phase multiplexing for two- and three-channel data transmission, (2) effects of phase noise on the performance of coherent communication links, (3) analysis of command system performance, (4) error correcting code tradeoffs, (5) signal detection and angular search procedure for the shuttle Ku-band communication system, and (6) false lock performance of Costas loop receivers.

  20. Integrated source and channel encoded digital communication system design study

    NASA Technical Reports Server (NTRS)

    Udalov, S.; Huth, G. K.

    1977-01-01

    The analysis of the forward link signal structure for the shuttle orbiter Ku-band communication system was carried out, based on the assumptions of a 3.03 Mcps PN code. It is shown that acquisition requirements for the forward link can be met at the acquisition threshold C/N0 sub 0 value of about 60 dB-Hz, which corresponds to a bit error rate (BER) of about 0.001. It is also shown that the tracking threshold for the forward link is at about 57 dB-Hz. The analysis of the bent pipe concept for the orbiter was carried out, along with the comparative analysis of the empirical data. The complexity of the analytical approach warrants further investigation to reconcile the empirical and theoretical results. Techniques for incorporating a text and graphics capability into the forward link data stream are considered and a baseline configuration is described.

  1. Identifying and Quantifying Ecological Changes in Channel Bank Systems in a Small California Agricultural Watershed

    NASA Astrophysics Data System (ADS)

    Florsheim, J. L.; Nichols, A. L.; Ustin, S.; Lay, M.

    2011-12-01

    episodic floods, with likely responses dependent on complex interactions between the landscape-scale legacy of past landuse, such as channel incision, flood magnitude and duration, and current landuses that may include grazing or restoration. Floods may cause bank erosion, expose tree roots, undercut trees, modify bars, or incise the channel bed. In a resilient watershed, the spatial heterogeneity in these processes creates and maintains dynamic bank and aquatic ecosystems and biodiversity. In contrast, in watersheds where channels are incised and human activities have denuded riparian vegetation, the system may have crossed a threshold such that a flood causes a regime shift between resiliency and degradation of channel bank habitat.

  2. Effect of channel catfish stocking rate on yield and water quality in an intensive production system

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The effect of stocking rate on production of NWAC 103 strain channel catfish (Ictalurus punctatus) and water quality was investigated using a completely randomized design in an intensively managed biofloc raceway system. Each of the 9 HDPE-lined raceways (4.6 m x 9.2 m with a 0.9-m water depth; 42.2...

  3. Report of Television Multi-Channel System in Lincoln Heights Elementary School Progress Report.

    ERIC Educational Resources Information Center

    WCET-TV, Cincinnati, OH.

    A comprehensive television (TV) and videotape system was installed in the elementary school in Lincoln Heights, Ohio, the nation's largest all-black city. With the support of industry and local educational television, every classroom was equipped with a six-channel closed circuit TV set and six headphones, at a cost of $42,250. The purpose of the…

  4. Channel Estimation and ISI/ICI Cancellation for MIMO-OFDM Systems with Insufficient Cyclic Prefix

    NASA Astrophysics Data System (ADS)

    Chiu, Yi-Jen; Chen, Chien-Sheng; Chang, Ting-Wei

    In multi-input multi-output orthogonal frequency division multiplexing (MIMO-OFDM) systems, the multipath components whose delays exceed cyclic prefix (CP) cause inter-symbol interference (ISI) and inter-carrier interference (ICI), which may degrade system performance severely. In this paper, we propose a joint channel estimation and ISI/ICI cancellation scheme in which a limited CP is used in a trade-off against high-rate performance in MIMO-OFDM systems. A channel estimation scheme based on the criterion of Expectation-Maximization (EM) algorithm can be proposed through the use of a training symbol. The EM algorithm uses an iterative procedure to estimate channel parameters and can estimate channel impulse response (CIR) accurately enough to mitigate ISI/ICI influences. Through the accurate CIR estimation, an efficient method has been developed to counteract ISI/ICI influences in signal detection in the case where the inserted CP length is less than the CIR length. Simulation results show that the proposed method can significantly enhance the overall MIMO-OFDM system performance after only a few iterations.

  5. A 128-channel picoammeter system and its application on charged particle beam current distribution measurements

    SciTech Connect

    Yu, Deyang Liu, Junliang; Xue, Yingli; Zhang, Mingwu; Cai, Xiaohong; Hu, Jianjun; Dong, Jinmei; Li, Xin

    2015-11-15

    A 128-channel picoammeter system is constructed based on instrumentation amplifiers. Taking advantage of a high electric potential and narrow bandwidth in DC energetic charged beam measurements, a current resolution better than 5 fA can be achieved. Two sets of 128-channel strip electrodes are implemented on printed circuit boards and are employed for ion and electron beam current distribution measurements. Tests with 60 keV O{sup 3+} ions and 2 keV electrons show that it can provide exact boundaries when a positive charged particle beam current distribution is measured.

  6. Quantum interference of stored dual-channel spin-wave excitations in a single tripod system

    SciTech Connect

    Wang Hai; Li Shujing; Xu Zhongxiao; Zhao Xingbo; Zhang Lijun; Li Jiahua; Wu Yuelong; Xie Changde; Peng Kunchi; Xiao Min

    2011-04-15

    We present an experimental demonstration of dual-channel memory in a single tripod atomic system. The total readout signal exhibits either constructive or destructive interference when the dual-channel spin-wave excitations (SWEs) are retrieved by two reading beams with a controllable relative phase. When the two reading beams have opposite phases, the SWEs will remain in the medium, which can be retrieved later with two in-phase reading beams. Such a phase-sensitive storage and retrieval scheme can be used to measure and control the relative phase between the two SWEs in the memory medium, which may find applications in quantum-information processing.

  7. Channel estimation for asymmetrically clipped optical orthogonal frequency division multiplexing communication system

    NASA Astrophysics Data System (ADS)

    Zhao, Hui; Li, Minghui; Wang, Ruyan; Wu, Dapeng

    2013-07-01

    The channel estimation problem for asymmetrically clipped optical orthogonal frequency division multiplexing wireless communication systems is investigated. In order to resolve the noise-sensitive problem of traditional least squares-based channel estimation method, a new channel estimation method which is based on superimposed training sequence and guarantees the linear minimum mean square error estimate is proposed. Cycle training sequence is added at variable power ratio to the information sequence at the transmitter prior to transmission. Then, statistical average method is employed to separate training and information sequences at the receiver. Simulation results show that the power ratio of training sequence needs to balance between the mean square error (MSE) of estimation and the error bit rate. Moreover, compared with the traditional least squares-based method, the proposed method has significantly improved the estimation performance under the condition of low signal-to-noise ratio, especially, when the MSE of the estimation reduces 1 to 2 orders.

  8. RF-SQUID to DC-SQUID upgrade of a 28-channel magnetoencephalography (MEG) system

    NASA Astrophysics Data System (ADS)

    Diekmann, V.; Jürgens, R.; Becker, W.; Elias, H.; Ludwig, W.; Vodel, W.

    1996-05-01

    A Dornier 28-channel magnetoencephalography (MEG) system equipped with RF-SQUIDs and control electronics made by CTF (Port Coquitlam, BC, Canada) was upgraded by replacing the RF-SQUIDs with DC-SQUIDs developed at the University of Jena, Germany. New preamplifiers were designed that emulate the function of the system's original RF amplifiers. This allowed the continuing use of the system's control electronics without any modification. Retaining these control devices was instrumental for preserving the system's unique ability to derive software-defined gradiometer measurements from its magnetometer signals, and also saved a considerable investment of control software tailored to the characteristics of these devices. The performance of the upgraded system compares favourably to that of other multichannel instruments; its software gradiometer channels typically attain an overall sensitivity of 0957-0233/7/5/017/img7 (an improvement by a factor of three over the original RF system) and suppress residual noise inside the shielded room by 40 to 60 dB. Also described are the procedures used to calibrate the system, to eliminate crosstalk between neighbouring channels, and to determine the coefficients for optimum suppression of ambient noise by the software gradiometer.

  9. Handheld 2-channel impedimetric cell counting system with embedded real-time processing

    NASA Astrophysics Data System (ADS)

    Rottigni, A.; Carminati, M.; Ferrari, G.; Vahey, M. D.; Voldman, J.; Sampietro, M.

    2011-05-01

    Lab-on-a-chip systems have been attracting a growing attention for the perspective of miniaturization and portability of bio-chemical assays. Here we present a the design and characterization of a miniaturized, USB-powered, self-contained, 2-channel instrument for impedance sensing, suitable for label-free tracking and real-time detection of cells flowing in microfluidic channels. This original circuit features a signal generator based on a direct digital synthesizer, a transimpedance amplifier, an integrated square-wave lock-in coupled to a Σ▵ ADC converter, and a digital processing platform. Real-time automatic peak detection on two channels is implemented in a FPGA. System functionality has been tested with an electronic resistance modulator to simulate 1% impedance variation produced by cells, reaching a time resolution of 50μs (enabling a count rate of 2000 events/s) with an applied voltage as low as 200mV. Biological experiments have been carried out counting yeast cells. Statistical analysis of events is in agreement with the expected amplitude and time distributions. 2-channel yeast counting has been performed with concomitant dielectrophoretic cell separation, showing that this novel and ultra compact sensing system, thanks to the selectivity of the lock-in detector, is compatible with other AC electrical fields applied to the device.

  10. Transient receptor potential (TRP) channels as drug targets for diseases of the digestive system

    PubMed Central

    Holzer, Peter

    2011-01-01

    Approximately 20 of the 30 mammalian transient receptor potential (TRP) channel subunits are expressed by specific neurons and cells within the alimentary canal. They subserve important roles in taste, chemesthesis, mechanosensation, pain and hyperalgesia and contribute to the regulation of gastrointestinal motility, absorptive and secretory processes, blood flow, and mucosal homeostasis. In a cellular perspective, TRP channels operate either as primary detectors of chemical and physical stimuli, as secondary transducers of ionotropic or metabotropic receptors, or as ion transport channels. The polymodal sensory function of TRPA1, TRPM5, TRPM8, TRPP2, TRPV1, TRPV3 and TRPV4 enables the digestive system to survey its physical and chemical environment, which is relevant to all processes of digestion. TRPV5 and TRPV6 as well as TRPM6 and TRPM7 contribute to the absorption of Ca2+ and Mg2+, respectively. TRPM7 participates in intestinal pacemaker activity, and TRPC4 transduces muscarinic acetylcholine receptor activation to smooth muscle contraction. Changes in TRP channel expression or function are associated with a variety of diseases/disorders of the digestive system, notably gastro-esophageal reflux disease, inflammatory bowel disease, pain and hyperalgesia in heartburn, functional dyspepsia and irritable bowel syndrome, cholera, hypomagnesemia with secondary hypocalcemia, infantile hypertrophic pyloric stenosis, esophageal, gastrointestinal and pancreatic cancer, and polycystic liver disease. These implications identify TRP channels as promising drug targets for the management of a number of gastrointestinal pathologies. As a result, major efforts are put into the development of selective TRP channel agonists and antagonists and the assessment of their therapeutic potential. PMID:21420431

  11. Stability assessment of QKD procedures in commercial quantum cryptography systems versus quality of dark channel

    NASA Astrophysics Data System (ADS)

    Jacak, Monika; Melniczuk, Damian; Jacak, Janusz; Jóźwiak, Ireneusz; Gruber, Jacek; Jóźwiak, Piotr

    2015-02-01

    In order to assess the susceptibility of the quantum key distribution (QKD) systems to the hacking attack including simultaneous and frequent system self-decalibrations, we analyze the stability of the QKD transmission organized in two commercially available systems. The first one employs non-entangled photons as flying qubits in the dark quantum channel for communication whereas the second one utilizes the entangled photon pairs to secretly share the cryptographic key. Applying standard methods of the statistical data analysis to the characteristic indicators of the quality of the QKD communication (the raw key exchange rate [RKER] and the quantum bit error rate [QBER]), we have estimated the pace of the self-decalibration of both systems and the repeatability rate in the case of controlled worsening of the dark channel quality.

  12. Waterhole form and process in the anastomosing channel system of Cooper Creek, Australia

    NASA Astrophysics Data System (ADS)

    Knighton, A. David; Nanson, Gerald C.

    2000-10-01

    One of the most distinctive features of Cooper Creek's anastomosing channel system is the preponderance of waterholes, enlarged segments of channel ranging in length from 100 m to over 20 km. Enlargement occurs in both the width and depth dimensions to give bankfull cross-sectional areas four to eight times the average size of individual anastomosing channels. The anastomosing system is cut into a floodplain of subtle relief but depths of incision can be highly variable, giving rise to changes in the degree of anastomosis as different sets of channels are activated during the filling stage of a flood. Also, cross-sectional form and bed topography can vary markedly over short channel distances, which has implications for local flow conditions and erosive potential. Hydraulic geometry analyses suggest that cross-sectional area adjusts much more readily than velocity to increasing discharge in waterholes, particularly if there is limited lateral confinement. Consequently, velocities tend to be rather modest across a wide spectrum of flows, with average values rarely reaching 1 m s -1. Nevertheless, observations made during a 1:20-year flood reveal a deeply penetrative band of relatively high velocity in one waterhole, suggesting that localized values of bed shear could be quite large even when sectional averages are moderate. Waterholes appear to be a product of the present regime, since they concentrate flow from both feeder channels and the floodplain during flood discharges. In several respects they resemble chains-of-ponds morphology [Eyles, R.J., 1977. Birchams Creek: the transition from a chain of ponds to a gully. Aust. Geogr. Stud. 15, 146-157.], and could represent the discontinuous sections of a present-day channel, which cannot be maintained in that form over its entire length. That the one waterhole to accommodate the entire cross-valley flow at bankfull stage (Meringhina Waterhole) has cross-sectional dimensions similar to those predicted by appropriate

  13. Channel coding and data compression system considerations for efficient communication of planetary imaging data

    NASA Technical Reports Server (NTRS)

    Rice, R. F.

    1974-01-01

    End-to-end system considerations involving channel coding and data compression are reported which could drastically improve the efficiency in communicating pictorial information from future planetary spacecraft. In addition to presenting new and potentially significant system considerations, this report attempts to fill a need for a comprehensive tutorial which makes much of this very subject accessible to readers whose disciplines lie outside of communication theory.

  14. Channel blockade in a two-path triple-quantum-dot system

    NASA Astrophysics Data System (ADS)

    Kotzian, M.; Gallego-Marcos, F.; Platero, G.; Haug, R. J.

    2016-07-01

    Electronic transport through a two-path triple-quantum-dot system with two source leads and one drain is studied and the interaction between the two paths is analyzed. We observe a channel blockade as a result of interchannel Coulombic interaction. The experimental results are understood with the help of a theoretical model which allows one to obtain the parameters of the system, the stability regions of each state, and the full dynamical transport in the triple-dot resonances.

  15. A Low Cost Compact 512 Channel Therapeutic Ultrasound System For Transcutaneous Ultrasound Surgery

    NASA Astrophysics Data System (ADS)

    Hall, Tim; Cain, Charles

    2006-05-01

    A low cost 512 channel therapeutic ultrasound system was designed and tested with a 2D array transducer. The system was optimized for high energy, low duty cycle pulsing applications (cavitation mediated therapy), but is also folly compatible with continuous wave applications. The effective steering range was measured to be 40 mm FWHM over a 3D volume. Well defined volumes of liver tissue were disrupted with high energy cavitation generating ultrasound pulses in ex-vivo liver experiments.

  16. A parallel finite element simulator for ion transport through three-dimensional ion channel systems.

    PubMed

    Tu, Bin; Chen, Minxin; Xie, Yan; Zhang, Linbo; Eisenberg, Bob; Lu, Benzhuo

    2013-09-15

    A parallel finite element simulator, ichannel, is developed for ion transport through three-dimensional ion channel systems that consist of protein and membrane. The coordinates of heavy atoms of the protein are taken from the Protein Data Bank and the membrane is represented as a slab. The simulator contains two components: a parallel adaptive finite element solver for a set of Poisson-Nernst-Planck (PNP) equations that describe the electrodiffusion process of ion transport, and a mesh generation tool chain for ion channel systems, which is an essential component for the finite element computations. The finite element method has advantages in modeling irregular geometries and complex boundary conditions. We have built a tool chain to get the surface and volume mesh for ion channel systems, which consists of a set of mesh generation tools. The adaptive finite element solver in our simulator is implemented using the parallel adaptive finite element package Parallel Hierarchical Grid (PHG) developed by one of the authors, which provides the capability of doing large scale parallel computations with high parallel efficiency and the flexibility of choosing high order elements to achieve high order accuracy. The simulator is applied to a real transmembrane protein, the gramicidin A (gA) channel protein, to calculate the electrostatic potential, ion concentrations and I - V curve, with which both primitive and transformed PNP equations are studied and their numerical performances are compared. To further validate the method, we also apply the simulator to two other ion channel systems, the voltage dependent anion channel (VDAC) and α-Hemolysin (α-HL). The simulation results agree well with Brownian dynamics (BD) simulation results and experimental results. Moreover, because ionic finite size effects can be included in PNP model now, we also perform simulations using a size-modified PNP (SMPNP) model on VDAC and α-HL. It is shown that the size effects in SMPNP can

  17. Compressed sensing theory-based channel estimation for optical orthogonal frequency division multiplexing communication system

    NASA Astrophysics Data System (ADS)

    Zhao, Hui; Li, Minghui; Wang, Ruyan; Liu, Yuanni; Song, Daiping

    2014-09-01

    Due to the spare multipath property of the channel, a channel estimation method, which is based on partial superimposed training sequence and compressed sensing theory, is proposed for line of sight optical orthogonal frequency division multiplexing communication systems. First, a continuous training sequence is added at variable power ratio to the cyclic prefix of orthogonal frequency division multiplexing symbols at the transmitter prior to transmission. Then the observation matrix of compressed sensing theory is structured by the use of the training symbols at receiver. Finally, channel state information is estimated using sparse signal reconstruction algorithm. Compared to traditional training sequences, the proposed partial superimposed training sequence not only improves the spectral efficiency, but also reduces the influence to information symbols. In addition, compared with classical least squares and linear minimum mean square error methods, the proposed compressed sensing theory based channel estimation method can improve both the estimation accuracy and the system performance. Simulation results are given to demonstrate the performance of the proposed method.

  18. Characterization of a mini-channel heat exchanger for a heat pump system

    NASA Astrophysics Data System (ADS)

    Arteconi, A.; Giuliani, G.; Tartuferi, M.; Polonara, F.

    2014-04-01

    In this paper a mini-channel aluminum heat exchanger used in a reversible heat pump is presented. Mini-channel finned heat exchangers are getting more and more interest for refrigeration systems, especially when compactness and low refrigerant charge are desired. Purpose of this paper was to characterize the mini-channel heat exchanger used as evaporator in terms of heat transfer performance and to study the refrigerant distribution in the manifold. The heat exchanger characterization was performed experimentally by means of a test rig built up for this purpose. It is composed of an air-to-air heat pump, air channels for the external and internal air circulation arranged in a closed loop, measurement sensors and an acquisition system. The overall heat transfer capacity was assessed. Moreover, in order to characterize the flow field of the refrigerant in the manifold of the heat exchanger, a numerical investigation of the fluid flow by means of CFD was performed. It was meant to evaluate the goodness of the present design and to identify possible solutions for the future improvement of the manifold design.

  19. Integrated optofluidic-microfluidic twin channels: toward diverse application of lab-on-a-chip systems

    PubMed Central

    Lv, Chao; Xia, Hong; Guan, Wei; Sun, Yun-Lu; Tian, Zhen-Nan; Jiang, Tong; Wang, Ying-Shuai; Zhang, Yong-Lai; Chen, Qi-Dai; Ariga, Katsuhiko; Yu, Yu-De; Sun, Hong-Bo

    2016-01-01

    Optofluidics, which integrates microfluidics and micro-optical components, is crucial for optical sensing, fluorescence analysis, and cell detection. However, the realization of an integrated system from optofluidic manipulation and a microfluidic channel is often hampered by the lack of a universal substrate for achieving monolithic integration. In this study, we report on an integrated optofluidic-microfluidic twin channels chip fabricated by one-time exposure photolithography, in which the twin microchannels on both surfaces of the substrate were exactly aligned in the vertical direction. The twin microchannels can be controlled independently, meaning that fluids could flow through both microchannels simultaneously without interfering with each other. As representative examples, a tunable hydrogel microlens was integrated into the optofluidic channel by femtosecond laser direct writing, which responds to the salt solution concentration and could be used to detect the microstructure at different depths. The integration of such optofluidic and microfluidic channels provides an opportunity to apply optofluidic detection practically and may lead to great promise for the integration and miniaturization of Lab-on-a-Chip systems. PMID:26823292

  20. Integrated optofluidic-microfluidic twin channels: toward diverse application of lab-on-a-chip systems.

    PubMed

    Lv, Chao; Xia, Hong; Guan, Wei; Sun, Yun-Lu; Tian, Zhen-Nan; Jiang, Tong; Wang, Ying-Shuai; Zhang, Yong-Lai; Chen, Qi-Dai; Ariga, Katsuhiko; Yu, Yu-De; Sun, Hong-Bo

    2016-01-01

    Optofluidics, which integrates microfluidics and micro-optical components, is crucial for optical sensing, fluorescence analysis, and cell detection. However, the realization of an integrated system from optofluidic manipulation and a microfluidic channel is often hampered by the lack of a universal substrate for achieving monolithic integration. In this study, we report on an integrated optofluidic-microfluidic twin channels chip fabricated by one-time exposure photolithography, in which the twin microchannels on both surfaces of the substrate were exactly aligned in the vertical direction. The twin microchannels can be controlled independently, meaning that fluids could flow through both microchannels simultaneously without interfering with each other. As representative examples, a tunable hydrogel microlens was integrated into the optofluidic channel by femtosecond laser direct writing, which responds to the salt solution concentration and could be used to detect the microstructure at different depths. The integration of such optofluidic and microfluidic channels provides an opportunity to apply optofluidic detection practically and may lead to great promise for the integration and miniaturization of Lab-on-a-Chip systems. PMID:26823292

  1. Integrated optofluidic-microfluidic twin channels: toward diverse application of lab-on-a-chip systems

    NASA Astrophysics Data System (ADS)

    Lv, Chao; Xia, Hong; Guan, Wei; Sun, Yun-Lu; Tian, Zhen-Nan; Jiang, Tong; Wang, Ying-Shuai; Zhang, Yong-Lai; Chen, Qi-Dai; Ariga, Katsuhiko; Yu, Yu-De; Sun, Hong-Bo

    2016-01-01

    Optofluidics, which integrates microfluidics and micro-optical components, is crucial for optical sensing, fluorescence analysis, and cell detection. However, the realization of an integrated system from optofluidic manipulation and a microfluidic channel is often hampered by the lack of a universal substrate for achieving monolithic integration. In this study, we report on an integrated optofluidic-microfluidic twin channels chip fabricated by one-time exposure photolithography, in which the twin microchannels on both surfaces of the substrate were exactly aligned in the vertical direction. The twin microchannels can be controlled independently, meaning that fluids could flow through both microchannels simultaneously without interfering with each other. As representative examples, a tunable hydrogel microlens was integrated into the optofluidic channel by femtosecond laser direct writing, which responds to the salt solution concentration and could be used to detect the microstructure at different depths. The integration of such optofluidic and microfluidic channels provides an opportunity to apply optofluidic detection practically and may lead to great promise for the integration and miniaturization of Lab-on-a-Chip systems.

  2. TRPV1 channel as a target for cancer therapy using CNT-based drug delivery systems.

    PubMed

    Ortega-Guerrero, Andres; Espinosa-Duran, John M; Velasco-Medina, Jaime

    2016-07-01

    Carbon nanotubes are being considered for the design of drug delivery systems (DDSs) due to their capacity to internalize molecules and control their release. However, for cellular uptake of drugs, this approach requires an active translocation pathway or a channel to transport the drug into the cell. To address this issue, it is suggested to use TRPV1 ion channels as a potential target for drug release by nano-DDSs since these channels are overexpressed in cancer cells and allow the permeation of large cationic molecules. Considering these facts, this work presents three studies using molecular dynamics simulations of a human TRPV1 (hTRPV1) channel built here. The purpose of these simulations is to study the interaction between a single-wall carbon nanotube (SWCNT) and hTRPV1, and the diffusion of doxorubicin (DOX) across hTRPV1 and across a POPC lipid membrane. The first study shows an attractive potential between the SWCNT surface and hTRPV1, tilting the adsorbed SWCNT. The second study shows low diffusion probability of DOX across the open hTRPV1 due to a high free energy barrier. Although, the potential energy between DOX and hTRPV1 reveals an attractive interaction while DOX is inside hTRPV1. These results suggest that if the channel is dilated, then DOX diffusion could occur. The third study shows a lower free energy barrier for DOX across the lipid membrane than for DOX across hTRPV1. Taking into account the results obtained, it is feasible to design novel nano-DDSs based on SWCNTs to accomplish controlled drug release into cells using as translocation pathway, the hTRPV1 ion channel.

  3. Electronic communication channel within the patient data management system improves internal communication in the ICU.

    PubMed

    Väisänen, Paula; Holopainen, Jaana

    2006-01-01

    The aim of this study was to improve the internal communication within the intensive care unit of the Kuopio University Hospital. We developed an intranet based internal communication channel within the patient data management system and studied the effectiveness of this system in improving communication in the ICU. The hypothesis was that the communication difficulties caused by the structure of the unit, large personnel and work schedule (three separate shifts) could be reduced by supplementing oral communication by this intranet based system. The results clearly indicate that this type of system can significantly improve communication within our unit. PMID:17102442

  4. The formation and maintenance of single-thread tie channels entering floodplain lakes: observations from three diverse river systems

    SciTech Connect

    Rowland, Joel C; Dietrich, William E; Day, Geoff; Parker, Gary

    2009-01-01

    Tie channels connect rivers to floodplain lakes on many lowland rivers and thereby play a central role in floodplain sedimentology and ecology, yet they are generally unrecognized and little studied. here we report the results of field studies focused on tie channel origin and morphodynamics in three contrasting systems: the Middle Fly River, Papua New Guinea, the Lower Mississippi River, and Birch Creek in Alaska. Across these river systems, tie channels vary by an order of magnitude in size but exhibit the same characteristic morphology and appear to develop and evolve by a similar set of processes. In all three systems, the channels are characterized by a narrow, leveed single-thread morphology with maximum width approximately one tenth the width of the mainstem river. The channels typically have a V shaped cross-section, unlike most fluvial channels. These channels develop as lakes become isolated from the river by sedimentation. Narrowing of the connection between river and lake causes a sediment-laden jet to develop. Levees develop along the margins of the jet leading to channel emergence and eventual levee aggradation to the height of the mainstem levees. Bi-directional flow in these channels is common. Outflows from the lake scour sediment and prevent channel blockage. We propose that channel geometry and size are then controlled by a dynamic balance between channel narrowing by suspended sediment deposition and incision and widening by mass failure of banks during outflows. Tie channels are laterally stable and may convey flow for hundreds to a few thousand of years.

  5. Formation and maintenance of single-thread tie channels entering floodplain lakes: Observations from three diverse river systems

    NASA Astrophysics Data System (ADS)

    Rowland, J. C.; Dietrich, W. E.; Day, G.; Parker, G.

    2009-06-01

    Tie channels connect rivers to floodplain lakes on many lowland rivers and thereby play a central role in floodplain sedimentology and ecology; yet they are generally unrecognized and little studied. Here we report the results of field studies focused on tie channel origin and morphodynamics in the following three contrasting systems: the Middle Fly River (Papua New Guinea), the Lower Mississippi River, and Birch Creek in Alaska. Across these river systems, tie channels vary by an order of magnitude in size but exhibit the same characteristic morphology and appear to develop and evolve by a similar set of processes. In all three systems, the channels are characterized by a narrow, leveed, single-thread morphology with maximum width approximately one tenth the width of the mainstem river. The channels typically have a V-shaped cross section, unlike most fluvial channels. These channels develop as lakes become isolated from the river by sedimentation. Narrowing of the connection between river and lake causes a sediment-laden jet to develop. Levees develop along the margins of the jet leading to channel emergence and eventual levee aggradation to the height of the mainstem levees. Bidirectional flow in these channels is common. Outflows from the lake scour sediment and prevent channel blockage. We propose that channel geometry and size are then controlled by a dynamic balance between channel narrowing by suspended sediment deposition and incision and widening by mass failure of banks during outflows. Tie channels are laterally stable and may convey flow for hundreds to a few thousand of years.

  6. Morphology and sedimentation along the Kongsfjord Channel System, Svalbard continental margin, European Arctic

    NASA Astrophysics Data System (ADS)

    Forwick, M.; Vorren, T. O.; Hass, C. H.; Laberg, J.; Vanneste, M.

    2011-12-01

    The continental margin off northwestern Svalbard (between 79° and 80° N) has been affected by repeated mass wasting, as well as from northward-flowing contourite currents. One on the most striking morphological features is the approximately 120 km long, SE-NW oriented Kongsfjord Channel System (KCS) that can be traced from the shelf break at 250-300 m water depth to a maximum water depth of about 4000 m. Several channels/gullies starting at the shelf break merge into the main channel at around 1400 m. The main channel is at maximum 500 m wide and 80 m deep. Repeated interaction of the channel with contourite deposition has occurred. This includes relocation of the channel's axis related to the northward migration of the contourites, as well as renewed incision of contourites by activitiy within the channel. Two sediment cores were retrieved from either side of the main channel at 1430 m water depth, and two from about 1560 m water depth, respectively. The stratigraphy of these cores can easily be correlated to dated cores from the west Spitsbergen continental margin (Jessen et al., 2010). Preliminary results reveal that the sedimentation rates (SRs) at the shallower locations are generally higher than at the deeper stations during the past c. 30,000 years. At the sites from 1430 m water depth, the SRs were rather uniform during the past c. 10,000 years. However, prior to c. 10,000 cal. years BP, the SRs were significantly higher at the location of the core that was retrieved northeast of the channel. We assume that this is related to enhanced down-slope sediment transport within the channel and deposition to the right (northeast) of the transport direction - due to the Coriolis force and/or the northward-flowing contourite currents. The sources for sediment transport within the channel are most probably 1) enhanced sediment supply from the Kongsfjorden ice stream during the last glacial, and 2) winnowing of fine-grained material in the upper parts of the KCS and

  7. HCN1 Channels Enhance Rod System Responsivity in the Retina under Conditions of Light Exposure

    PubMed Central

    Sothilingam, Vithiyanjali; Michalakis, Stylianos; Garcia Garrido, Marina; Biel, Martin

    2016-01-01

    Purpose Vision originates in rods and cones at the outer retina. Already at these early stages, diverse processing schemes shape and enhance image information to permit perception over a wide range of lighting conditions. In this work, we address the role of hyperpolarization-activated and cyclic nucleotide-gated channels 1 (HCN1) in rod photoreceptors for the enhancement of rod system responsivity under conditions of light exposure. Methods To isolate HCN1 channel actions in rod system responses, we generated double mutant mice by crossbreeding Hcn1-/- mice with Cnga3-/- mice in which cones are non-functional. Retinal function in the resulting Hcn1-/- Cnga3-/- animals was followed by means of electroretinography (ERG) up to the age of four month. Retinal imaging via scanning laser ophthalmoscopy (SLO) and optical coherence tomography (OCT) was also performed to exclude potential morphological alterations. Results This study on Hcn1-/- Cnga3-/- mutant mice complements our previous work on HCN1 channel function in the retina. We show here in a functional rod-only setting that rod responses following bright light exposure terminate without the counteraction of HCN channels much later than normal. The resulting sustained signal elevation does saturate the retinal network due to an intensity-dependent reduction in the dynamic range. In addition, the lack of rapid adaptational feedback modulation of rod photoreceptor output via HCN1 in this double mutant limits the ability to follow repetitive (flicker) stimuli, particularly under mesopic conditions. Conclusions This work corroborates the hypothesis that, in the absence of HCN1-mediated feedback, the amplitude of rod signals remains at high levels for a prolonged period of time, leading to saturation of the retinal pathways. Our results demonstrate the importance of HCN1 channels for regular vision. PMID:26807953

  8. Receptors, channels, and signalling in the urothelial sensory system in the bladder.

    PubMed

    Merrill, Liana; Gonzalez, Eric J; Girard, Beatrice M; Vizzard, Margaret A

    2016-04-01

    The storage and periodic elimination of urine, termed micturition, requires a complex neural control system to coordinate the activities of the urinary bladder, urethra, and urethral sphincters. At the level of the lumbosacral spinal cord, lower urinary tract reflex mechanisms are modulated by supraspinal controls with mechanosensory input from the urothelium, resulting in regulation of bladder contractile activity. The specific identity of the mechanical sensor is not yet known, but considerable interest exists in the contribution of transient receptor potential (TRP) channels to the mechanosensory functions of the urothelium. The sensory, transduction, and signalling properties of the urothelium can influence adjacent urinary bladder tissues including the suburothelial nerve plexus, interstitial cells of Cajal, and detrusor smooth muscle cells. Diverse stimuli, including those that activate TRP channels expressed by the urothelium, can influence urothelial release of chemical mediators (such as ATP). Changes to the urothelium are associated with a number of bladder pathologies that underlie urinary bladder dysfunction. Urothelial receptor and/or ion channel expression and the release of signalling molecules (such as ATP and nitric oxide) can be altered with bladder disease, neural injury, target organ inflammation, or psychogenic stress. Urothelial receptors and channels represent novel targets for potential therapies that are intended to modulate micturition function or bladder sensation. PMID:26926246

  9. Episodic Channels: Effects of Regulation on Non-Equilibrium River Systems in California (Invited)

    NASA Astrophysics Data System (ADS)

    Kondolf, G. M.; Minear, J. T.

    2010-12-01

    Mediterranean-climate rivers are characterized by episodic channels, whose geomorphic work is concentrated in short, infrequent events (large floods), separated by long periods of quiescence in which the channel narrows and riparian vegetation can establish and mature, only to be disrupted by the next large disturbance. While not ‘pretty’ in conventional terms, such rivers support diverse assemblages of native species, adapted to the episodic regime. Because of the importance of irrigated agriculture in Mediterranean-climate regions, large reservoir storage projects are common, resulting in dam-induced reductions flood peaks, which have reduced dynamism in downstream channels. The result has been loss of habitat diversity and native species. A systems-level analysis of the Sacramento-San Joaquin and other rivers reveals that Q2 has commonly been reduced by 80%, sediment loads reduced, and vegetation encroached in formerly active channels. More profound have been hardening of banks and isolation of floodplains by levees. Restoration of ecological values in such rivers will require room for the river to move and flood, as well as floods sufficient to drive these processes. We identify a set of rivers with highest potential for re-activation or preservation of dynamic process in California.

  10. Power Scaling of Uplink Massive MIMO Systems With Arbitrary-Rank Channel Means

    NASA Astrophysics Data System (ADS)

    Zhang, Qi; Jin, Shi; Wong, Kai-Kit; Zhu, Hongbo; Matthaiou, Michail

    2014-10-01

    This paper investigates the uplink achievable rates of massive multiple-input multiple-output (MIMO) antenna systems in Ricean fading channels, using maximal-ratio combining (MRC) and zero-forcing (ZF) receivers, assuming perfect and imperfect channel state information (CSI). In contrast to previous relevant works, the fast fading MIMO channel matrix is assumed to have an arbitrary-rank deterministic component as well as a Rayleigh-distributed random component. We derive tractable expressions for the achievable uplink rate in the large-antenna limit, along with approximating results that hold for any finite number of antennas. Based on these analytical results, we obtain the scaling law that the users' transmit power should satisfy, while maintaining a desirable quality of service. In particular, it is found that regardless of the Ricean $K$-factor, in the case of perfect CSI, the approximations converge to the same constant value as the exact results, as the number of base station antennas, $M$, grows large, while the transmit power of each user can be scaled down proportionally to $1/M$. If CSI is estimated with uncertainty, the same result holds true but only when the Ricean $K$-factor is non-zero. Otherwise, if the channel experiences Rayleigh fading, we can only cut the transmit power of each user proportionally to $1/\\sqrt M$. In addition, we show that with an increasing Ricean $K$-factor, the uplink rates will converge to fixed values for both MRC and ZF receivers.

  11. TransportDB: a comprehensive database resource for cytoplasmic membrane transport systems and outer membrane channels.

    PubMed

    Ren, Qinghu; Chen, Kaixi; Paulsen, Ian T

    2007-01-01

    TransportDB (http://www.membranetransport.org/) is a comprehensive database resource of information on cytoplasmic membrane transporters and outer membrane channels in organisms whose complete genome sequences are available. The complete set of membrane transport systems and outer membrane channels of each organism are annotated based on a series of experimental and bioinformatic evidence and classified into different types and families according to their mode of transport, bioenergetics, molecular phylogeny and substrate specificities. User-friendly web interfaces are designed for easy access, query and download of the data. Features of the TransportDB website include text-based and BLAST search tools against known transporter and outer membrane channel proteins; comparison of transporter and outer membrane channel contents from different organisms; known 3D structures of transporters, and phylogenetic trees of transporter families. On individual protein pages, users can find detailed functional annotation, supporting bioinformatic evidence, protein/DNA sequences, publications and cross-referenced external online resource links. TransportDB has now been in existence for over 10 years and continues to be regularly updated with new evidence and data from newly sequenced genomes, as well as having new features added periodically.

  12. On the delay effects of different channels in Internet-based networked control systems

    NASA Astrophysics Data System (ADS)

    Zhao, Yun-Bo; Kim, Jongrae; Sun, Xi-Ming; Liu, Guo-Ping

    2013-11-01

    The sensor-to-controller and the controller-to-actuator delays in networked control systems (NCSs) are investigated for the first time with respect to their different effects on the system performance. This study starts with identifying the delay-independent and delay-dependent control laws in NCSs, and confirms that only two delay-dependent control laws can cause different delay effects in different channels. The conditions under which the different delays in different channels can cause different effects are then given for both delay-dependent control laws. The results are verified by numerical examples. Potentially, these results can be regarded as important design principles in the practical implementation of NCSs.

  13. Design and study of the elevation difference channel feed of the single aperture monopulse feed system

    NASA Astrophysics Data System (ADS)

    Shukla, S. R.

    1987-07-01

    The technique to generate the higher order modes TE(11) and TM(11) in the square waveguide, required for the E plane error single channel feed in the single aperture monopulse feed system, has been presented and the appropriate assembly for this purpose has been designed in the 8.5-9.0 GHz frequency band. The assembly can be incorporated as an E plane error signal channel feed in the design of a single aperture monopulse feed system. The features of the design are a suppressed cross-polarized component of the radiation field and a deep null in the E plane pattern at the boresight axis of the feed. A qualitative explanation for the behavior of the feed has been presented.

  14. Seismic features and evolution of a late Miocene submarine channel system in the Yinggehai basin, northwestern South China Sea

    NASA Astrophysics Data System (ADS)

    Sun, H.; Jiang, T.; Wang, Z.; Zhang, Y.

    2014-12-01

    Submarine channel is one of key conduits for coarse terrigenous clastic sediments to abyssal plain, which provides the possibility for deepwater hydrocarbon exploration. Recently, a new high-quality 3D seismic data is acquired in south Yinggehai basin (YGHB) and the detailed interpretations on those seismic profiles as well as RMS amplitude attributes and variance slices reveal a submarine channel system developed in late Miocene, which could be supplied from Hainan Island via turbidity currents so that it would be filled with sand-rich turbidites as good hydrocarbon reservoir. Based on the integration between regional seismic survey and some boreholes, the investigations on its infilling architectures and depositional processes are carried out. The results show that it composes two converged submarine channels with two channelized submarine fans to their west and the main submarine channel (MSC) is characterized by a downstream increasing width and is infilled by sediments with high amplitude seismic facies, which could be originated from channelized submarine fans. Furthermore, the complicated depositional processes around the confluence region of these two channels are pointed out and the interactions between the submarine channel system and nearby channelized submarine fans are discussed. The detailed illustration on the seismic features and depositional processes of the subsurface submarine system provides us better understanding deepwater sedimentary dynamics and would be more benefit for the hydrocarbon exploration in similar deepwater area around the world.

  15. Application of the Hardman methodology to the Single Channel Ground-Airborne Radio System (SINCGARS)

    NASA Technical Reports Server (NTRS)

    1984-01-01

    The HARDMAN methodology was applied to the various configurations of employment for an emerging Army multipurpose communications system. The methodology was used to analyze the manpower, personnel and training (MPT) requirements and associated costs, of the system concepts responsive to the Army's requirement for the Single Channel Ground-Airborne Radio System (SINCGARS). The scope of the application includes the analysis of two conceptual designs Cincinnati Electronics and ITT Aerospace/Optical Division for operating and maintenance support addressed through the general support maintenance echelon.

  16. Characterization and calibration of 8-channel E-band heterodyne radiometer system for SST-1 tokamak

    SciTech Connect

    Siju, Varsha; Kumar, Dharmendra; Shukla, Praveena; Pathak, S. K.

    2014-05-15

    An 8-channel E-band heterodyne radiometer system (74–86 GHz) is designed, characterized, and calibrated to measure the radial electron temperature profile by measuring Electron Cyclotron Emission spectrum at SST-1 Tokamak. The developed radiometer has a noise equivalent temperature of 1 eV and sensitivity of 5 × 10{sup 9} V/W. In order to precisely measure the absolute value of electron temperature, a calibration measurement of the radiometer system is performed using hot-cold Dicke switch method, which confirms the system linearity.

  17. Environmental testing of a prototypic digital safety channel, Phase I: System design and test methodology

    SciTech Connect

    Korsah, K.; Turner, G.W.; Mullens, J.A.

    1995-04-01

    A microprocessor-based reactor trip channel has been assembled for environmental testing under an Instrumentation and Control (I&C) Qualification Program sponsored by the US Nuclear Regulatory Commission. The goal of this program is to establish the technical basis and acceptance criteria for the qualification of advanced I&C systems. The trip channel implemented for this study employs technologies and digital subsystems representative of those proposed for use in some advanced light-water reactors (ALWRs) such as the Simplified Boiling Water Reactor (SBWR). It is expected that these tests will reveal any potential system vulnerabilities for technologies representative of those proposed for use in ALWRs. The experimental channel will be purposely stressed considerably beyond what it is likely to experience in a normal nuclear power plant environment, so that the tests can uncover the worst-case failure modes (i.e., failures that are likely to prevent an entire trip system from performing its safety function when required to do so). Based on information obtained from this study, it may be possible to recommend tests that are likely to indicate the presence of such failure mechanisms. Such recommendations would be helpful in augmenting current qualification guidelines.

  18. Performance analysis of a finite radon transform in OFDM system under different channel models

    SciTech Connect

    Dawood, Sameer A.; Anuar, M. S.; Fayadh, Rashid A.; Malek, F.; Abdullah, Farrah Salwani

    2015-05-15

    In this paper, a class of discrete Radon transforms namely Finite Radon Transform (FRAT) was proposed as a modulation technique in the realization of Orthogonal Frequency Division Multiplexing (OFDM). The proposed FRAT operates as a data mapper in the OFDM transceiver instead of the conventional phase shift mapping and quadrature amplitude mapping that are usually used with the standard OFDM based on Fast Fourier Transform (FFT), by the way that ensure increasing the orthogonality of the system. The Fourier domain approach was found here to be the more suitable way for obtaining the forward and inverse FRAT. This structure resulted in a more suitable realization of conventional FFT- OFDM. It was shown that this application increases the orthogonality significantly in this case due to the use of Inverse Fast Fourier Transform (IFFT) twice, namely, in the data mapping and in the sub-carrier modulation also due to the use of an efficient algorithm in determining the FRAT coefficients called the optimal ordering method. The proposed approach was tested and compared with conventional OFDM, for additive white Gaussian noise (AWGN) channel, flat fading channel, and multi-path frequency selective fading channel. The obtained results showed that the proposed system has improved the bit error rate (BER) performance by reducing inter-symbol interference (ISI) and inter-carrier interference (ICI), comparing with conventional OFDM system.

  19. A sophisticated, multi-channel data acquisition and processing system for high frequency noise research

    NASA Technical Reports Server (NTRS)

    Hall, David G.; Bridges, James

    1992-01-01

    A sophisticated, multi-channel computerized data acquisition and processing system was developed at the NASA LeRC for use in noise experiments. This technology, which is available for transfer to industry, provides a convenient, cost-effective alternative to analog tape recording for high frequency acoustic measurements. This system provides 32-channel acquisition of microphone signals with an analysis bandwidth up to 100 kHz per channel. Cost was minimized through the use of off-the-shelf components. Requirements to allow for future expansion were met by choosing equipment which adheres to established industry standards for hardware and software. Data processing capabilities include narrow band and 1/3 octave spectral analysis, compensation for microphone frequency response/directivity, and correction of acoustic data to standard day conditions. The system was used successfully in a major wind tunnel test program at NASA LeRC to acquire and analyze jet noise data in support of the High Speed Civil Transport (HSCT) program.

  20. An automated injection system for sub-micron sized channels used in shear-driven-chromatography.

    PubMed

    De Malsche, Wim; Clicq, David; Eghbali, Hamed; Fekete, Veronika; Gardeniers, Han; Desmet, Gert

    2006-10-01

    This paper describes a method to automatically and reproducibly inject sharply delimited sample plugs in the shallow (i.e., sub-micron) channels typically used in shear driven chromatography. The formation of asymmetric plugs, which typically occurs during loading of the sample in wide channels, is circumvented by etching a slit in the middle of the channel that is connected to a micro-well and a vacuum system with syringes for the supply of both the analyte and the mobile phase. The design of the injection slit was supported by a series of CFD simulations to optimize its shape and that of the corresponding injection well. The system was intensively tested experimentally and showed good reproducibility, both for the width and the area of the injected peaks (relative standard deviations are max. 4 and 6%, respectively). The concentration of the injected plug was found to be approximately 80% of the original sample concentration. It was also observed that with the current setup the lower limit of the peak width was about 120 microm. This is a consequence of the fact that the peak width originating from the convection filling step becomes negligible to the contribution of diffusion during the filling and flushing time. Being fully automated and perfectly closed, the presently proposed injection system also paves the way to integrate other functionalities in shear driven chromatography, i.e. gradient elution and parallelization. PMID:17102846

  1. Extended horizon lifting for periodic gain adjustment in control systems, and for equalization of communication channels

    NASA Technical Reports Server (NTRS)

    Bayard, David S. (Inventor)

    1994-01-01

    Periodic gain adjustment in plants of irreducible order, n, or for equalization of communications channels is effected in such a way that the plant (system) appears to be minimum phase by choosing a horizon time N is greater than n of liftings in periodic input and output windows rho sub u and rho sub y, respectively, where N is an integer chosen to define the extent (length) of each of the windows rho sub u and rho sub y, and n is the order of an irreducible input/output plant. The plant may be an electrical, mechanical, or chemical system, in which case output tracking (OT) is carried out for feedback control or a communication channel, in which case input tracking (IT) is performed. Conditions for OT are distinct from IT in terms of zero annihilation, namely H(sub s)H(sub s)(sup +) = I for OT and H(sub s)H(sub s)(sup +) = I of IT, where the OT conditions are intended for gain adjustments in the control system, and IT conditions are intended for equalization for communication channels.

  2. Designing Effective Persuasive Systems Utilizing the Power of Entanglement: Communication Channel, Strategy and Affect

    NASA Astrophysics Data System (ADS)

    Li, Haiqing; Chatterjee, Samir

    With rapid advances in information and communication technology, computer-mediated communication (CMC) technologies are utilizing multiple IT platforms such as email, websites, cell-phones/PDAs, social networking sites, and gaming environments. However, no studies have compared the effectiveness of a persuasive system using such alternative channels and various persuasive techniques. Moreover, how affective computing impacts the effectiveness of persuasive systems is not clear. This study proposes (1) persuasive technology channels in combination with persuasive strategies will have different persuasive effectiveness; (2) Adding positive emotion to a message that leads to a better overall user experience could increase persuasive effectiveness. The affective computing or emotion information was added to the experiment using emoticons. The initial results of a pilot study show that computer-mediated communication channels along with various persuasive strategies can affect the persuasive effectiveness to varying degrees. These results also shows that adding a positive emoticon to a message leads to a better user experience which increases the overall persuasive effectiveness of a system.

  3. The sensitivity and selectivity of an implantable two-channel peroneal nerve stimulator system for restoration of dropped foot.

    PubMed

    Kottink, Anke I R; Buschman, Hendrik P J; Kenney, Laurence P J; Veltink, Peter H; Slycke, Per; Bultstra, Gerrit; Hermens, Hermie J

    2004-10-01

    The objective of this study was to evaluate the stimulation responses on each channel of an implantable two-channel stimulator that stimulates the peroneal nerve branches innervating the muscles for dorsiflexion and eversion movements. Currently five Dutch patients and five English patients have been implanted with this system. Isometric ankle torque measurements were carried out in the patient with the longest follow-up period (1 y). A force sensor measured the three components of moment generated at the ankle joint. Stimulation intensity can be adjusted with great accuracy. Dorsiflexion moments are almost entirely determined by the setting of channel 1. Eversion moments are determined mainly by channel 2 and to a lesser extent by channel 1. Both channels determined abduction/adduction moments. We conclude that stimulation responses in both dorsiflexion and eversion direction can be set individually and with great accuracy and are reproducible over a prolonged period. PMID:22151337

  4. Eight channel - 16 bit, bidirectional analog to digital monitoring and control system

    SciTech Connect

    Allen, J.C.; Callis, R.W.; Cary, W.P.; Harris, T.E.; Nerem, A.

    1991-11-01

    The DIII-D tokamak facility is currently upgrading its electron cyclotron resonance heating (ECH) system. The new system is based on 110 GHz gyrotrons developed by Varian. As part of this upgrade, the superconducting magnet power supplies were required to be remotely controlled and monitored accurately. The 110 GHz gyrotron superconducting magnet has eight coils, that are energized by current regulating power supplies. An analog to digital (A/D) system was designed to allow remote coil current monitoring and power supply programming. The A/D system is an eight channel multiplexed, 16 bit, bidirectional, fiber optically linked, analog to digital telemetry system. Design concerns and trade-offs will be discussed as will the results of in system use.

  5. Systems biology of ion channels and transporters in tumor angiogenesis: An omics view.

    PubMed

    Munaron, L

    2015-10-01

    Solid tumors require the formation of new blood vessels to support their growth, invasiveness and metastatic potential. Tumor neovascularization is achieved by vasculogenesis from endothelial precursors and by sprouting angiogenesis from preexisting vessels. The complex sequence of events driving these processes, including endothelial activation, proliferation, migration and differentiation, is associated with fluxes of ions, water and other small molecules mediated by a great pool of ion channels and transporters (ICT). This 'transportome' is regulated by environmental factors as well as intracellular signaling molecules. In turn, ICT play a prominent role in the response to angiogenesis-related stimuli through canonical and 'unconventional' activities: indeed, there is an increasing recognition of the multifunctionality of several ion channels that could also be annotated as receptors, enzymes, scaffolding proteins, mechanical and chemical sensors. The investigation of ICT structure and function has been far from the experimental oncology for long time and these two domains converged only very recently. Furthermore, the systems biology viewpoint has not received much attention in the biology of cancer transportome. Modulating angiogenesis by interference with membrane transport has a great potential in cancer treatment and the application of an 'omics' logic will hopefully contribute to the overall advancement in the field. This review is an attempt to apply the systems biology approach to the analysis of ICT involved in tumor angiogenesis, with a particular focus on endothelial transportome diversity. This article is part of a Special Issue entitled: Membrane channels and transporters in cancers.

  6. Design and application of multi-channel simultaneous detection system for well-earth potential

    NASA Astrophysics Data System (ADS)

    Lei, Shao; Jun, Lin; Wei, Jianrong; Sui, Yangyi; Wu, Ziyu

    2007-07-01

    Well-earth ERT (electrical resistance tomography) technology is an important geophysical exploration method which studies the location distribution of remaining oil. Based on virtual instrument technology, the author designs a set of multi-channel simultaneous detection system. It adopts multi-channel simultaneous sampling, bipolar and differential inputs, analog LPF (low pass filter), FIR digital filter, and linear accumulated digital averaging method or techniques to suppress electromagnetic noise and improve SNR (signal-to-noise ratio); uses digital signal process method to remove the overshoot, avoided huge errors and improved accuracy of measurement; adopts feedback compensative method to exclude the influence of SP(spontaneous potential) and cover a wide dynamic measurable scope; spectrum analysis method is used for judging all electrodes earthing situation correctly; the USB2.0 technique is used to solve the problem of bulky multi-channel data transmission to achieve high-speed data transmission between hardware and PC. The Liao He oilfield survey results show that the system is characterized with high efficiency, portable and strong antijiamming capability.

  7. A wireless multi-channel bioimpedance measurement system for personalized healthcare and lifestyle.

    PubMed

    Ramos, Javier; Ausín, José Luis; Lorido, Antonio Manuel; Redondo, Francisco; Duque-Carrillo, Juan Francisco

    2013-01-01

    Miniaturized, noninvasive, wearable sensors constitute a fundamental prerequisite for pervasive, predictive, and preventive healthcare systems. In this sense, this paper presents the design, realization, and evaluation of a wireless multi-channel measurement system based on a cost-effective high-performance integrated circuit for electrical bioimpedance (EBI) measurements in the frequency range from 1 kHz to 1 MHz. The resulting on-chip spectrometer provides high measuring EBI capabilities and together with a low-cost, commercially available radio frequency transceiver device. It provides reliable wireless communication, constitutes the basic node to build EBI wireless sensor networks (EBI-WSNs). The proposed EBI-WSN behaves as a high-performance wireless multi-channel EBI spectrometer, where the number of channels is completely scalable and independently configurable to satisfy specific measurement requirements of each individual. A prototype of the EBI node leads to a very small printed circuit board of approximately 8 cm2 including chip-antenna, which can operate several years on one 3-V coin cell battery and make it suitable for long-term preventive healthcare monitoring. PMID:23739358

  8. One bit/s/Hz Spectrally Efficient Transmission for an Eight-Channel NRZ-Modulated DWDM System

    NASA Astrophysics Data System (ADS)

    Vij, Robin; Sharma, Neeraj

    2016-03-01

    The core of the global telecommunication network consists of wavelength-division multiplexed (WDM) optical transmission systems. WDM is the technology of choice as it allows for a high spectral efficiency. We propose an effective way to counter the nonlinearities like four-wave mixing and cross-phase modulation to achieve the spectral efficiency of 1 bit/s/Hz using non-return-to-zero (NRZ) modulation format. We use the concept of non-uniform channel spacing and non-uniform power assignment between adjacent channels of the WDM system. We have simulated an eight-channel WDM lightwave system with bit rates of 10 and 25 Gbit/s.

  9. Development of 200-channel mapping system for tissue oxygenation measured by near-infrared spectroscopy

    NASA Astrophysics Data System (ADS)

    Niwayama, Masatsugu; Kohata, Daisuke; Shao, Jun; Kudo, Nobuki; Hamaoka, Takatumi; Katsumura, Toshihito; Yamamoto, Katsuyuki

    2000-07-01

    Near-infrared spectroscopy (NIRS) is a very useful technique for noninvasive measurement of tissue oxygenation. Among various methods of NIRS, continuous wave near-infrared spectroscopy (CW- NIRS) is especially suitable for real-time measurement and for practical use. CW-NIRS has recently been applied in vivo reflectance imaging of muscle oxygenation and brain activity. However, conventional mapping systems do not have a sufficient mapping area at present. Moreover, they do not enable quantitative measurement of tissue oxygenation because conventional NIRS is based on the inappropriate assumption that tissue is homogeneous. In this study, we developed a 200-channel mapping system that enables measurement of changes in oxygenation and blood volume and that covers a wider area (30 cm x 20 cm) than do conventional systems. The spatial resolution (source- detector separation) of this system is 15 mm. As for the effcts of tissue inhomogeneity on muscle oxygenation measurement, subcutaneous adipose tissue greatly reduces measurement sensitivity. Therefore, we also used a correction method for influence of the subcutaneous fat layer so that we could obtain quantitative changes in concentrations of oxy- and deoxy- hemoglobin. We conducted exercise tests and measured the changed in hemoglobin concentration in the thigh using the new system. The working muscles in the exercises could be imaged, and the heterogeneity of the muscles was shown. These results demonstrated the new 200-channel mapping system enables observation of the distribution of muscle metabolism and localization of muscle function.

  10. Under-sampling in a Multiple-Channel Laser Vibrometry System

    SciTech Connect

    Corey, Jordan

    2007-03-01

    Laser vibrometry is a technique used to detect vibrations on objects using the interference of coherent light with itself. Most vibrometry systems process only one target location at a time, but processing multiple locations simultaneously provides improved detection capabilities. Traditional laser vibrometry systems employ oversampling to sample the incoming modulated-light signal, however as the number of channels increases in these systems, certain issues arise such a higher computational cost, excessive heat, increased power requirements, and increased component cost. This thesis describes a novel approach to laser vibrometry that utilizes undersampling to control the undesirable issues associated with over-sampled systems. Undersampling allows for significantly less samples to represent the modulated-light signals, which offers several advantages in the overall system design. These advantages include an improvement in thermal efficiency, lower processing requirements, and a higher immunity to the relative intensity noise inherent in laser vibrometry applications. A unique feature of this implementation is the use of a parallel architecture to increase the overall system throughput. This parallelism is realized using a hierarchical multi-channel architecture based on off-the-shelf programmable logic devices (PLDs).

  11. Cat-eye target imaging system research and dual-channel DSP implementation

    NASA Astrophysics Data System (ADS)

    Zheng, Zheng; Zhang, Haiyang; Shi, Guang; Han, Lei; Zhao, Changming

    2013-09-01

    In modern warfare, well-equipped and trained snipers have become a mortal malady for the combat troops. How to accurately, timely and quickly find and destroy snipers becomes a research focus of national military experts. In order to effectively detect faint echo signal of cat-eye target and get the snipers' position information in the detection area, a small size of dual-channel active laser detection system with monochrome and color Charge-couple Devices(CCD) is designed, which is based on the laser imaging principle of cat-eye effect, associated tests are also conducted. The dual-channel video capture can obtain more information of target area, while taking advantage of the high sensitivity of monochrome CCD will also provide more accurate grayscale information for the video image processing. In order to achieve the miniaturization of system, we choose a video processing board whose size is only 54mm*90mm as hardware platform to complete the algorithm. For verifying the feasibility and accuracy of algorithm, we ultimately build a full set of experimental detection system. The test results show that the system can accurately detect and mark typical cat-eye target from background under different distances, which verifies the rationality and validity of the proposed system and has certain practicality and promotion in the active laser detection system research areas.

  12. Coupled-rearrangement-channels calculation of the three-body system under the absorbing boundary condition

    NASA Astrophysics Data System (ADS)

    Iwasaki, M.; Otani, R.; Ito, M.; Kamimura, M.

    2016-06-01

    We formulate the absorbing boundary condition (ABC) in the coupled rearrangement-channels variational method (CRCVM) for the three-body problem. The absorbing potential is introduced in the system of the identical three-bosons, on which the boson symmetry is explicitly imposed by considering the rearrangement channels. The resonance parameters and the strength of the monopole breakup are calculated by the CRCVM + ABC method, and the results are compared with the complex scaling method (CSM). We have found that the results of the ABC method are consistent with the CSM results. The effect of the boson symmetry, which is often neglected in the calculation of the triple α reactions, is also discussed.

  13. Laboratory flume experiments for characterising Martian channels formed by distinct groundwater systems

    NASA Astrophysics Data System (ADS)

    Marra, Wouter A.; Kleinhans, Maarten G.; McLelland, Stuart J.; Murphy, Brendan J.; Parsons, Daniel R.; Conway, Susan J.; Hauber, Ernst

    2013-04-01

    Channels on Mars have been found in many locations and across all possible scales, suggesting the presence of flowing water in the past. Several hypotheses for the formation of these channels have been proposed, including a role for groundwater. In this study we explored the development of channel morphology for three types of groundwater systems: 1) seepage from a regional groundwater system, 2) seepage from local precipitation and 3) groundwater release from a pressurised aquifer. We performed a series of scale experiments to study the morphological development of different scenarios. Smaller scale experiments were conducted in a setup of 1x3x0.25 m (at UU) using lightweight plastic sediment. Larger scale experiments were conducted in a setup of 4x6x1 m (at UoH) using sand. To simulate the three aforementioned hydrological conditions, 1) a constant sub-surface hydraulic head was applied using a header tank connected to the sediment, 2) a series of rainfall simulator nozzles were used (UoH setup only) and 3) a super-surface hydraulic pressure was applied to a perforated pipe beneath the sediment. The two scales of experiments allow us to assess the scalability to real-world conditions. We collected detailed DEMs and time-lapse imagery of the morphological development of the sediment surface. In the regional groundwater experiments, elongated valleys with circular, steep head walls developed, with depths down to the groundwater table. The valley heads and sides developed as a result of mass wasting processes; within the valley material was transported by fluvial processes. Multiple parallel valleys formed initially, but one or two eventually capture most of the outflow and became larger than the pirated valleys. In the precipitation-fed seepage experiments, groundwater flowed from all directions into valleys rather than just from upstream. Again, multiple parallel valleys with semi-circular heads formed but the valleys were shallower and wider. Channel formation by

  14. Optical-network-connected multi-channel 96-GHz-band distributed radar system

    NASA Astrophysics Data System (ADS)

    Kanno, Atsushi; Kuri, Toshiaki; Kawanishi, Tetsuya

    2015-05-01

    The millimeter-wave (MMW) radar is a promising candidate for high-precision imaging because of its short wavelength and broad range of available bandwidths. In particular in the frequency range of 92-100 GHz, which is regulated for radiolocation, an atmospheric attenuation coefficient less than 1 dB/km limits the imaging range. Therefore, a combination of MMW radar and distributed antenna system directly connected to optical fiber networks can realize both high-precision imaging and large-area surveillance. In this paper, we demonstrate a multi-channel MMW frequency-modulated continuous-wave distributed radar system connected to an analog radio-over-fiber network.

  15. New analytical equation for dispersion in estuaries with a distinct ebb-flood channel system

    NASA Astrophysics Data System (ADS)

    Nguyen, Anh Duc; Savenije, Hubert H. G.; van der Wegen, Mick; Roelvink, Dano

    2008-08-01

    Tidal pumping caused by residual horizontal circulation is an important but ill-understood mechanism producing longitudinal salt dispersion in well-mixed estuaries. There are two types of residual circulation that cause tidal pumping: (1) interaction of the tidal flow with a pronounced flood-ebb channel system; and (2) interaction of the tidal flow with an irregular bathymetry. Residual ebb-flood channel circulation is an important large-scale mixing mechanism for salinity intrusion, as shown in the Western Scheldt in the Netherlands, which is a well-mixed estuary with a distinct ebb-flood channel system. This paper provides a new simplified conceptual model and a new analytical equation for this type of mixing. Firstly, using a fully three-dimensional hydrodynamic model as a "virtual laboratory" and employing a decomposition method, the characteristics of the residual ebb-flood channel circulation in the Western Scheldt are analysed. Secondly, a conceptual model and an analytical equation determining the dispersion coefficient are developed, which take into account relevant parameters for tidal pumping, such as the tidal pumping efficiency, the tidal excursion and the length of the branches. Subsequently, the newly developed equation is compared to the results of the "virtual laboratory". The comparison confirms an agreement between the newly developed equation and the "virtual laboratory" in determining the residual transport and the tidal pumping dispersion coefficient. Finally, the equation is applied to observations in the Western Scheldt. The application yields good results in determining the longitudinal dispersion compared to dispersion values obtained from the salt budget.

  16. Eugenol dilates mesenteric arteries and reduces systemic BP by activating endothelial cell TRPV4 channels

    PubMed Central

    Peixoto-Neves, Dieniffer; Wang, Qian; Leal-Cardoso, Jose H; Rossoni, Luciana V; Jaggar, Jonathan H

    2015-01-01

    Background and Purpose Eugenol, a vanilloid molecule found in some dietary plants, relaxes vasculature in part via an endothelium-dependent process; however, the mechanisms involved are unclear. Here, we investigated the endothelial cell-mediated mechanism by which eugenol modulates rat mesenteric artery contractility and systemic BP. Experimental Approach The isometric tension of rat mesenteric arteries (size 200–300 μm) was measured using wire myography; non-selective cation currents (ICat) were recorded in endothelial cells using patch clamp electrophysiology. Mean arterial pressure (MAP) and heart rate (HR) were determined in anaesthetized rats. Key Results Eugenol relaxed endothelium-intact arteries in a concentration-dependent manner and this effect was attenuated by endothelium denudation. L-NAME, a NOS inhibitor, a combination of TRAM-34 and apamin, selective blockers of intermediate and small conductance Ca2+-activated K+ channels, respectively, and HC-067047, a TRPV4 channel inhibitor, but not indomethacin, a COX inhibitor, reduced eugenol-induced relaxation in endothelium-intact arteries. Eugenol activated HC-067047-sensitive ICat in mesenteric artery endothelial cells. Short interfering RNA (siRNA)-mediated TRPV4 knockdown abolished eugenol-induced ICat activation. An i.v. injection of eugenol caused an immediate, transient reduction in both MAP and HR, which was followed by prolonged, sustained hypotension in anaesthetized rats. This sustained hypotension was blocked by HC-067047. Conclusions and Implications Eugenol activates TRPV4 channels in mesenteric artery endothelial cells, leading to vasorelaxation, and reduces systemic BP in vivo. Eugenol may be therapeutically useful as an antihypertensive agent and is a viable molecular candidate from which to develop second-generation TRPV4 channel activators that reduce BP. PMID:25832173

  17. CCSDS Advanced Orbiting Systems Virtual Channel Access Service for QoS MACHETE Model

    NASA Technical Reports Server (NTRS)

    Jennings, Esther H.; Segui, John S.

    2011-01-01

    To support various communications requirements imposed by different missions, interplanetary communication protocols need to be designed, validated, and evaluated carefully. Multimission Advanced Communications Hybrid Environment for Test and Evaluation (MACHETE), described in "Simulator of Space Communication Networks" (NPO-41373), NASA Tech Briefs, Vol. 29, No. 8 (August 2005), p. 44, combines various tools for simulation and performance analysis of space networks. The MACHETE environment supports orbital analysis, link budget analysis, communications network simulations, and hardware-in-the-loop testing. By building abstract behavioral models of network protocols, one can validate performance after identifying the appropriate metrics of interest. The innovators have extended the MACHETE model library to include a generic link-layer Virtual Channel (VC) model supporting quality-of-service (QoS) controls based on IP streams. The main purpose of this generic Virtual Channel model addition was to interface fine-grain flow-based QoS (quality of service) between the network and MAC layers of the QualNet simulator, a commercial component of MACHETE. This software model adds the capability of mapping IP streams, based on header fields, to virtual channel numbers, allowing extended QoS handling at link layer. This feature further refines the QoS v existing at the network layer. QoS at the network layer (e.g. diffserv) supports few QoS classes, so data from one class will be aggregated together; differentiating between flows internal to a class/priority is not supported. By adding QoS classification capability between network and MAC layers through VC, one maps multiple VCs onto the same physical link. Users then specify different VC weights, and different queuing and scheduling policies at the link layer. This VC model supports system performance analysis of various virtual channel link-layer QoS queuing schemes independent of the network-layer QoS systems.

  18. Design and implementation of the parallel processing system of multi-channel polarization images

    NASA Astrophysics Data System (ADS)

    Li, Zhi-yong; Huang, Qin-chao

    2013-08-01

    Compared with traditional optical intensity image processing, polarization images processing has two main problems. One is that the amount of data is larger. The other is that processing tasks is more complex. To resolve these problems, the parallel processing system of multi-channel polarization images is designed by the multi-DSP technique. It contains a communication control unit (CCU) and a data processing array (DPA). CCU controls communications inside and outside the system. Its logics are designed by a FPGA chip. DPA is made up of four Digital Signal Processor (DSP) chips, which are interlinked by the loose coupling method. DPA implements processing tasks including images registration and images synthesis by parallel processing methods. The polarization images parallel processing model is designed on multi levels including the system task, the algorithm and the operation. Its program is designed by the assemble language. While the polarization image resolution is 782x582 pixels, the pixel data length is 12 bits in the experiment. After it received 3 channels of polarization image simultaneously, this system implements parallel task to acquire the target polarization characteristics. Experimental results show that this system has good real-time and reliability. The processing time of images registration is 293.343ms while the registration accuracy achieves 0.5 pixel. The processing time of images synthesis is 3.199ms.

  19. Spectral Dynamics Inc., ships hybrid, 316-channel data acquisition system to Sandia Labs.

    SciTech Connect

    Schwartz, Douglas

    2003-09-01

    Spectral Dynamics announced the shipment of a 316-channel data acquisition system. The system was custom designed for the Light Initiated High Explosive (LIHE) facility at Sandia Labs in Albuquerque, New Mexico by Spectral Dynamics Advanced Research Products Group. This Spectral Dynamics data acquisition system was tailored to meet the unique LIHE environmental and testing requirements utilizing Spectral Dynamics commercial off the shelf (COTS) Jaguar and VIDAS products supplemented by SD Alliance partner's (COTS) products. 'This system is just the beginning of our cutting edge merged technology solutions,' stated Mark Remelman, Manager for the Spectral Dynamics Advanced Research Products Group. 'This Hybrid system has 316-channels of data acquisition capability, comprised of 102.4kHz direct to disk acquisition and 2.5MHz, 200Mhz & 500Mhz RAM based capabilities. In addition it incorporates the advanced bridge conditioning and dynamic configuration capabilities offered by Spectral Dynamics new Smart Interface Panel System (SIPS{trademark}).' After acceptance testing, Tony King, the Instrumentation Engineer facilitating the project for the Sandia LIHE group commented; 'The LIHE staff was very impressed with the design, construction, attention to detail and overall performance of the instrumentation system'. This system combines VIDAS, a leading edge fourth generation SD-VXI hardware and field-proven software system from SD's Advanced Research Products Group with SD's Jaguar, a multiple Acquisition Control Peripheral (ACP) system that allows expansion to hundreds of channels without sacrificing signal processing performance. Jaguar incorporates dedicated throughput disks for each ACP providing time streaming to disk at up to the maximum sample rate. Spectral Dynamics, Inc. is a leading worldwide supplier of systems and software for advanced computer-automated data acquisition, vibration testing, structural dynamics, explosive shock, high-speed transient capture

  20. Localization of P-type calcium channels in the central nervous system.

    PubMed

    Hillman, D; Chen, S; Aung, T T; Cherksey, B; Sugimori, M; Llinás, R R

    1991-08-15

    The distribution of the P-type calcium channel in the mammalian central nervous system has been demonstrated immunohistochemically by using a polyclonal specific antibody. This antibody was generated after P-channel isolation via a fraction from funnel-web spider toxin (FTX) that blocks the voltage-gated P channels in cerebellar Purkinje cells. In the cerebellar cortex, immunolabeling to the antibody appeared throughout the molecular layer, while all the other regions were negative. Intensely labeled patches of reactivity were seen on Purkinje cell dendrites, especially at bifurcations; much weaker reactivity was present in the soma and stem segment. Electron microscopic localization revealed labeled patches of plasma membrane on the soma, main dendrites, spiny branchlets, and spines; portions of the smooth endoplasmic reticulum were also labeled. Strong labeling was present in the periglomerular cells of the olfactory bulb and scattered neurons in the deep layer of the entorhinal and pyriform cortices. Neurons in the brainstem, habenula, nucleus of the trapezoid body and inferior olive and along the floor of the fourth ventricle were also labeled intensely. Medium-intensity reactions were observed in layer II pyramidal cells of the frontal cortex, the CA1 cells of the hippocampus, the lateral nucleus of the substantia nigra, lateral reticular nucleus, and spinal fifth nucleus. Light labeling was seen in the neocortex, striatum, and in some brainstem neurons.

  1. High-throughput hyperpolarized 13C metabolic investigations using a multi-channel acquisition system

    NASA Astrophysics Data System (ADS)

    Lee, Jaehyuk; Ramirez, Marc S.; Walker, Christopher M.; Chen, Yunyun; Yi, Stacey; Sandulache, Vlad C.; Lai, Stephen Y.; Bankson, James A.

    2015-11-01

    Magnetic resonance imaging and spectroscopy of hyperpolarized (HP) compounds such as [1-13C]-pyruvate have shown tremendous potential for offering new insight into disease and response to therapy. New applications of this technology in clinical research and care will require extensive validation in cells and animal models, a process that may be limited by the high cost and modest throughput associated with dynamic nuclear polarization. Relatively wide spectral separation between [1-13C]-pyruvate and its chemical endpoints in vivo are conducive to simultaneous multi-sample measurements, even in the presence of a suboptimal global shim. Multi-channel acquisitions could conserve costs and accelerate experiments by allowing acquisition from multiple independent samples following a single dissolution. Unfortunately, many existing preclinical MRI systems are equipped with only a single channel for broadband acquisitions. In this work, we examine the feasibility of this concept using a broadband multi-channel digital receiver extension and detector arrays that allow concurrent measurement of dynamic spectroscopic data from ex vivo enzyme phantoms, in vitro anaplastic thyroid carcinoma cells, and in vivo in tumor-bearing mice. Throughput and the cost of consumables were improved by up to a factor of four. These preliminary results demonstrate the potential for efficient multi-sample studies employing hyperpolarized agents.

  2. Aircraft Engine On-Line Diagnostics Through Dual-Channel Sensor Measurements: Development of a Baseline System

    NASA Technical Reports Server (NTRS)

    Kobayashi, Takahisa; Simon, Donald L.

    2008-01-01

    In this paper, a baseline system which utilizes dual-channel sensor measurements for aircraft engine on-line diagnostics is developed. This system is composed of a linear on-board engine model (LOBEM) and fault detection and isolation (FDI) logic. The LOBEM provides the analytical third channel against which the dual-channel measurements are compared. When the discrepancy among the triplex channels exceeds a tolerance level, the FDI logic determines the cause of the discrepancy. Through this approach, the baseline system achieves the following objectives: (1) anomaly detection, (2) component fault detection, and (3) sensor fault detection and isolation. The performance of the baseline system is evaluated in a simulation environment using faults in sensors and components.

  3. Cardiac ion channel safety profiling on the IonWorks Quattro automated patch clamp system.

    PubMed

    Cao, Xueying; Lee, Yan Tony; Holmqvist, Mats; Lin, Yingxin; Ni, Yucheng; Mikhailov, Dmitri; Zhang, Haiyan; Hogan, Christopher; Zhou, Liping; Lu, Qiang; Digan, Mary Ellen; Urban, Laszlo; Erdemli, Gül

    2010-12-01

    The normal electrophysiologic behavior of the heart is determined by the integrated activity of specific cardiac ionic currents. Mutations in genes encoding the molecular components of individual cardiac ion currents have been shown to result in multiple cardiac arrhythmia syndromes. Presently, 12 genes associated with inherited long QT syndrome (LQTS) have been identified, and the most common mutations are in the hKCNQ1 (LQT1, Jervell and Lange-Nielson syndrome), hKCNH2 (LQT2), and hSCN5A (LQT3, Brugada syndrome) genes. Several drugs have been withdrawn from the market or received black box labeling due to clinical cases of QT interval prolongation, ventricular arrhythmias, and sudden death. Other drugs have been denied regulatory approval owing to their potential for QT interval prolongation. Further, off-target activity of drugs on cardiac ion channels has been shown to be associated with increased mortality in patients with underlying cardiovascular diseases. Since clinical arrhythmia risk is a major cause for compound termination, preclinical profiling for off-target cardiac ion channel interactions early in the drug discovery process has become common practice in the pharmaceutical industry. In the present study, we report assay development for three cardiac ion channels (hKCNQ1/minK, hCa(v)1.2, and hNa(v)1.5) on the IonWorks Quattro™ system. We demonstrate that these assays can be used as reliable pharmacological profiling tools for cardiac ion channel inhibition to assess compounds for cardiac liability during drug discovery.

  4. The Santa Barbara Channel - Santa Maria Basin Study: A model for Coastal Ocean Observing Systems

    NASA Astrophysics Data System (ADS)

    Winant, C. D.

    2002-12-01

    The need to anticipate the potential impact of oil exploration and production activities on coastal resources, and the information needs of agencies charged with responding to coastal emergencies motivated the development of the oil-spill response system for the Santa Barbara Channel (SBC) and the Santa Maria Basin (SMB), along the California coast, between Ventura and Morro Bay. In the Santa Barbara Channel (SBC), moorings and drifter trajectories document a persistent cyclonic circulation with a typical re-circulation period between three and five days. In the spring currents near the mainland are weaker than near the Channel Islands and the overall flow is toward the southeast. Trajectories document the possibility for water parcels to leave the channel through the inter-island passes. In the late fall and winter, a poleward flow with velocities often exceeding 0.5 m/s is confined within 20 km of the mainland. Between these two seasons, the cyclonic tendency is enhanced although most of the drifters eventually migrate westward. The trajectories of drifters released at the same time from sites only 20 km apart can be remarkably different. In the Santa Maria Basin (SMB), the direction and amplitude of the flow is strongly depth dependent. Near the surface, moorings and drifters show the flow to be equatorward except during late fall and early winter when the surface flow is poleward. Beneath the surface layer the flow is poleward except in March and April, right after the spring transition. The observations provide a basis on which several data assimilating model of the circulation are based. The models reproduce all the major observed features of the circulation, including individual drifter trajectories. With little effort these models could be used to maintain an operational predictive capability with real predictive skills over periods of a few days.

  5. Theoretical influence of third molecule on reaction channels of weakly bound complex CO2? HF systems

    NASA Astrophysics Data System (ADS)

    Chen, Shyh-Jong; Chen, Cheng; Hong, Yaw-Shun

    In this investigation, reaction channels of weakly bound complexes CO2?HF, CO2?HF?NH3, CO2?HF?H2O and CO2?HF?CH3OH systems were established at the B3LYP/6-311++G(3df,2pd) level, using the Gaussian 98 program. The conformers of syn-fluoroformic acid or syn-fluoroformic acid plus a third molecule (NH3, H2O, or CH3OH) were found to be more stable than the conformers of the related anti-fluoroformic acid or anti-fluoroformic acid plus a third molecule (NH3, H2O, or CH3OH). However, the weakly bound complexes were found to be more stable than either the related syn- and anti-type fluoroformic acid or the acid plus third molecule (NH3, H2O, or CH3OH) conformers. They decomposed into CO2 + HF, CO2 + NH4F, CO2 + H3OF or CO2 + (CH3)OH2F combined molecular systems. The weakly bound complexes have four reaction channels, each of which includes weakly bound complexes and related systems. Moreover, each reaction channel includes two transition state structures. The transition state between the weakly bound complex and anti-fluoroformic acid type structure (T13) is significantly larger than that of internal rotation (T23) between the syn- and anti-FCO2H (or FCO2H?NH3, FCO2H?H2O, or FCO2H?CH3OH) structures. However, adding the third molecule NH3, H2O, or CH3OH can significantly reduce the activation energy of T13. The catalytic strengths of the third molecules are predicted to follow the order H2O < NH3 < CH3OH.

  6. Equalization in redundant channels

    NASA Technical Reports Server (NTRS)

    Tulpule, Bhalchandra R. (Inventor); Collins, Robert E. (Inventor); Cominelli, Donald F. (Inventor); O'Neill, Richard D. (Inventor)

    1988-01-01

    A miscomparison between a channel's configuration data base and a voted system configuration data base in a redundant channel system having identically operating, frame synchronous channels triggers autoequalization of the channel's historical signal data bases in a hierarchical, chronological manner with that of a correctly operating channel. After equalization, symmetrization of the channel's configuration data base with that of the system permits upgrading of the previously degraded channel to full redundancy. An externally provided equalization command, e.g., manually actuated, can also trigger equalization.

  7. Equalization enhanced phase noise in Nyquist-spaced superchannel transmission systems using multi-channel digital back-propagation.

    PubMed

    Xu, Tianhua; Liga, Gabriele; Lavery, Domaniç; Thomsen, Benn C; Savory, Seb J; Killey, Robert I; Bayvel, Polina

    2015-09-14

    Superchannel transmission spaced at the symbol rate, known as Nyquist spacing, has been demonstrated for effectively maximizing the optical communication channel capacity and spectral efficiency. However, the achievable capacity and reach of transmission systems using advanced modulation formats are affected by fibre nonlinearities and equalization enhanced phase noise (EEPN). Fibre nonlinearities can be effectively compensated using digital back-propagation (DBP). However EEPN which arises from the interaction between laser phase noise and dispersion cannot be efficiently mitigated, and can significantly degrade the performance of transmission systems. Here we report the first investigation of the origin and the impact of EEPN in Nyquist-spaced superchannel system, employing electronic dispersion compensation (EDC) and multi-channel DBP (MC-DBP). Analysis was carried out in a Nyquist-spaced 9-channel 32-Gbaud DP-64QAM transmission system. Results confirm that EEPN significantly degrades the performance of all sub-channels of the superchannel system and that the distortions are more severe for the outer sub-channels, both using EDC and MC-DBP. It is also found that the origin of EEPN depends on the relative position between the carrier phase recovery module and the EDC (or MC-DBP) module. Considering EEPN, diverse coding techniques and modulation formats have to be applied for optimizing different sub-channels in superchannel systems.

  8. Equalization enhanced phase noise in Nyquist-spaced superchannel transmission systems using multi-channel digital back-propagation

    PubMed Central

    Xu, Tianhua; Liga, Gabriele; Lavery, Domaniç; Thomsen, Benn C.; Savory, Seb J.; Killey, Robert I.; Bayvel, Polina

    2015-01-01

    Superchannel transmission spaced at the symbol rate, known as Nyquist spacing, has been demonstrated for effectively maximizing the optical communication channel capacity and spectral efficiency. However, the achievable capacity and reach of transmission systems using advanced modulation formats are affected by fibre nonlinearities and equalization enhanced phase noise (EEPN). Fibre nonlinearities can be effectively compensated using digital back-propagation (DBP). However EEPN which arises from the interaction between laser phase noise and dispersion cannot be efficiently mitigated, and can significantly degrade the performance of transmission systems. Here we report the first investigation of the origin and the impact of EEPN in Nyquist-spaced superchannel system, employing electronic dispersion compensation (EDC) and multi-channel DBP (MC-DBP). Analysis was carried out in a Nyquist-spaced 9-channel 32-Gbaud DP-64QAM transmission system. Results confirm that EEPN significantly degrades the performance of all sub-channels of the superchannel system and that the distortions are more severe for the outer sub-channels, both using EDC and MC-DBP. It is also found that the origin of EEPN depends on the relative position between the carrier phase recovery module and the EDC (or MC-DBP) module. Considering EEPN, diverse coding techniques and modulation formats have to be applied for optimizing different sub-channels in superchannel systems. PMID:26365422

  9. Traveling waves for the FitzHugh-Nagumo system on an infinite channel

    NASA Astrophysics Data System (ADS)

    Chen, Chao-Nien; Chen, Chiun-Chuan; Huang, Chih-Chiang

    2016-09-01

    We are concerned with the traveling wave solutions for the FitzHugh-Nagumo system on an infinite channel. Based on a variational formulation in which a non-local term depends on a parameter, the speed of a traveling wave can be selected out. Furthermore, to show the existence of a traveling wave solution with such a speed, we seek a minimizer subject to a constraint. In the way of solving the variational problem, we apply a truncation technique to the nonlocal term to obtain a minimizer located in a bounded invariant region.

  10. 71. VIEW OF STANDARD QUINTRON SYSTEMS, INC., 20CHANNEL COMMUNICATIONS PANEL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    71. VIEW OF STANDARD QUINTRON SYSTEMS, INC., 20-CHANNEL COMMUNICATIONS PANEL (RIGHT BOTTOM); AMPLIFIER (RIGHT MIDDLE); AND SLAVE COMMUNICATIONS PANEL (LEFT BOTTOM). TOP OF RIGHT PANEL CONTAINS AN AM/FM RADIO RECIEVER THAT IS NOT RELATED TO THE SLC-3 COMMUNICATIONS NETWORK. THESE PANELS LOCATED IN THE CENTER OF THE LONG CONSOLE NEAR THE SOUTHEAST CORNER OF THE SLC-3E CONTROL ROOM. (See background of CA-133-1-A-56.) - Vandenberg Air Force Base, Space Launch Complex 3, Launch Operations Building, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

  11. Space communication system for compressed data with a concatenated Reed-Solomon-Viterbi coding channel

    NASA Technical Reports Server (NTRS)

    Rice, R. F.; Hilbert, E. E. (Inventor)

    1976-01-01

    A space communication system incorporating a concatenated Reed Solomon Viterbi coding channel is discussed for transmitting compressed and uncompressed data from a spacecraft to a data processing center on Earth. Imaging (and other) data are first compressed into source blocks which are then coded by a Reed Solomon coder and interleaver, followed by a convolutional encoder. The received data is first decoded by a Viterbi decoder, followed by a Reed Solomon decoder and deinterleaver. The output of the latter is then decompressed, based on the compression criteria used in compressing the data in the spacecraft. The decompressed data is processed to reconstruct an approximation of the original data-producing condition or images.

  12. Effect of channel size on sweet potato storage root enlargement in the Tuskegee University hydroponic nutrient film system

    NASA Technical Reports Server (NTRS)

    Morris, Carlton E.; Martinez, Edwin; Bonsi, C. K.; Mortley, Desmond G.; Hill, Walter A.; Ogbuehi, Cyriacus R.; Loretan, Phil A.

    1989-01-01

    The potential of the sweet potato as a food source for future long term manned space missions is being evaluated for NASA's Controlled Ecological Life Support Systems (CELSS) program. Sweet potatoes have been successfully grown in a specially designed Tuskegee University nutrient film technique (TU NFT) system. This hydroponic system yielded storage roots as high as 1790 g/plant fresh weight. In order to determine the effect of channel size on the yield of sweet potatoes, the width and depth of the growing channels were varied in two separate experiments. Widths were studied using the rectangular TU NFT channels with widths of 15 cm (6 in), 30 cm (12 in) and 45 cm (18 in). Channel depths of 5 cm (2 in), 10 cm (4 in), and 15 cm (6 in) were studied using a standard NASA fan shaped Biomass Production Chamber (BPC) channel. A comparison of preliminary results indicated that, except for storage root number, the growth and yield of sweet potatoes were not affected by channel width. Storage root yield was affected by channel depth although storage root number and foliage growth were not. Both experiments are being repeated.

  13. A Catchment-Based Hydrologic and Routing Modeling System with explicit river channels

    NASA Astrophysics Data System (ADS)

    Goteti, Gopi; Famiglietti, James S.; Asante, Kwabena

    2008-07-01

    In this paper, we present a macroscale hydrologic modeling system with an explicit representation of storage and movement of water in river channels and floodplains. The overall modeling system, called the Catchment-Based Hydrologic and Routing Modeling System (CHARMS), is composed of a land surface model and a river routing model that operate on a network of hydrologic catchments (or watersheds). The land surface model in CHARMS is based on the National Center for Atmospheric Research Community Land Model. The river routing model in CHARMS generates river discharge by transporting runoff generated by the catchment-based CLM through the river network. The routing model uses information on channel cross-section geometry, derived from the 90 m Shuttle Radar Topography Mission digital elevation model, to simulate river discharge and the associated flow depth and inundation width. CHARMS was implemented over the Wabash River basin in the central United States (drainage area 72282 km2), and simulated streamflow was validated using daily observations. Simulated flow depth and inundation extent generally followed seasonal variations in observed flooding and droughts. Limitations of some of the assumptions and scaling factors used in this study and the issues that need to be addressed for a continental- or global-scale implementation of CHARMS are discussed. This paper serves as the foundation for a catchment-based, global land surface modeling framework that could incorporate spatiotemporal variations in surface water bodies, as well as satellite measurements of these variations.

  14. Unique properties of the ATP-sensitive K⁺ channel in the mouse ventricular cardiac conduction system.

    PubMed

    Bao, Li; Kefaloyianni, Eirini; Lader, Joshua; Hong, Miyoun; Morley, Gregory; Fishman, Glenn I; Sobie, Eric A; Coetzee, William A

    2011-12-01

    Background- The specialized cardiac conduction system (CCS) expresses a unique complement of ion channels that confer a specific electrophysiological profile. ATP-sensitive potassium (K(ATP)) channels in these myocytes have not been systemically investigated. Methods and Results- We recorded K(ATP) channels in isolated CCS myocytes using Cntn2-EGFP reporter mice. The CCS K(ATP) channels were less sensitive to inhibitory cytosolic ATP compared with ventricular channels and more strongly activated by MgADP. They also had a smaller slope conductance. The 2 types of channels had similar intraburst open and closed times, but the CCS K(ATP) channel had a prolonged interburst closed time. CCS K(ATP) channels were strongly activated by diazoxide and less by levcromakalim, whereas the ventricular K(ATP) channel had a reverse pharmacological profile. CCS myocytes express elevated levels of Kir6.1 but reduced Kir6.2 and SUR2A mRNA compared with ventricular myocytes (SUR1 expression was negligible). SUR2B mRNA expression was higher in CCS myocytes relative to SUR2A. Canine Purkinje fibers expressed higher levels of Kir6.1 and SUR2B protein relative to the ventricle. Numeric simulation predicts a high sensitivity of the Purkinje action potential to changes in ATP:ADP ratio. Cardiac conduction time was prolonged by low-flow ischemia in isolated, perfused mouse hearts, which was prevented by glibenclamide. Conclusions- These data imply a differential electrophysiological response (and possible contribution to arrhythmias) of the ventricular CCS to K(ATP) channel opening during periods of ischemia.

  15. The possible role of Coriolis forces in structuring large-scale sinuous patterns of submarine channel-levee systems.

    PubMed

    Wells, Mathew; Cossu, Remo

    2013-01-01

    Submarine channel-levee systems are among the largest sedimentary structures on the ocean floor. These channels have a sinuous pattern and are the main conduits for turbidity currents to transport sediment to the deep ocean. Recent observations have shown that their sinuosity decreases strongly with latitude, with high-latitude channels being much straighter than similar channels near the Equator. One possible explanation is that Coriolis forces laterally deflect turbidity currents so that at high Northern latitudes both the density interface and the downstream velocity maximum are deflected to the right-hand side of the channel (looking downstream). The shift in the velocity field can change the locations of erosion and deposition and introduce an asymmetry between left- and right-turning bends. The importance of Coriolis forces is defined by two Rossby numbers, RoW=U/Wf and RoR=U/Rf, where U is the mean downstream velocity, W is the width of the channel, R is the radius of curvature and f is the Coriolis parameter. In a bending channel, the density interface is flat when RoR∼-1, and Coriolis forces start to shift the velocity maximum when |RoW|<5. We review recent experimental and field observations and describe how Coriolis forces could lead to straighter channels at high latitudes.

  16. The possible role of Coriolis forces in structuring large-scale sinuous patterns of submarine channel-levee systems.

    PubMed

    Wells, Mathew; Cossu, Remo

    2013-12-13

    Submarine channel-levee systems are among the largest sedimentary structures on the ocean floor. These channels have a sinuous pattern and are the main conduits for turbidity currents to transport sediment to the deep ocean. Recent observations have shown that their sinuosity decreases strongly with latitude, with high-latitude channels being much straighter than similar channels near the Equator. One possible explanation is that Coriolis forces laterally deflect turbidity currents so that at high Northern latitudes both the density interface and the downstream velocity maximum are deflected to the right-hand side of the channel (looking downstream). The shift in the velocity field can change the locations of erosion and deposition and introduce an asymmetry between left- and right-turning bends. The importance of Coriolis forces is defined by two Rossby numbers, Ro(W) = U/Wf and Ro(R) = U/Rf, where U is the mean downstream velocity, W is the width of the channel, R is the radius of curvature and f is the Coriolis parameter. In a bending channel, the density interface is flat when Ro(R) - -1, and Coriolis forces start to shift the velocity maximum when [Row] < 5. We review recent experimental and field observations and describe how Coriolis forces could lead to straighter channels at high latitudes.

  17. Multi-Channel Magnetocardiogardiography System Based on Low-Tc SQUIDs in an Unshielded Environment

    NASA Astrophysics Data System (ADS)

    Kong, Xiangyan; Zhang, Shulin; Wang, Yongliang; Zeng, Jia; Xie, Xiaoming

    Magnetocardiography (MCG) using superconducting quantum interference devices (SQUIDs) is a new medical diagnostic tool measuring biomagnetic signals that are generated by the electrical activity of the human heart. This technique is completely passive, contactless, and it has an advantage in the early diagnosis of heart diseases. We developed the first unshielded four-channel MCG system based on low-Tc DC SQUIDs in China. Instead of using a costly magnetically shielded room, the environmental noise suppression was realized by using second-order gradiometers and three-axis reference magnetometer. The measured magnetic field resolution of the system is better than 1 pT, and multi-cycle human heart signals can be recorded directly. Also, with the infrared positioning system, 48 points data collection can be realized by moving the non-magnetic bed nine times.

  18. Acid-Sensing Ion Channels as Potential Pharmacological Targets in Peripheral and Central Nervous System Diseases.

    PubMed

    Radu, Beatrice Mihaela; Banciu, Adela; Banciu, Daniel Dumitru; Radu, Mihai

    2016-01-01

    Acid-sensing ion channels (ASICs) are widely expressed in the body and represent good sensors for detecting protons. The pH drop in the nervous system is equivalent to ischemia and acidosis, and ASICs are very good detectors in discriminating slight changes in acidity. ASICs are important pharmacological targets being involved in a variety of pathophysiological processes affecting both the peripheral nervous system (e.g., peripheral pain, diabetic neuropathy) and the central nervous system (e.g., stroke, epilepsy, migraine, anxiety, fear, depression, neurodegenerative diseases, etc.). This review discusses the role played by ASICs in different pathologies and the pharmacological agents acting on ASICs that might represent promising drugs. As the majority of above-mentioned pathologies involve not only neuronal dysfunctions but also microvascular alterations, in the next future, ASICs may be also considered as potential pharmacological targets at the vasculature level. Perspectives and limitations in the use of ASICs antagonists and modulators as pharmaceutical agents are also discussed.

  19. Laboratory measurements and a theoretical analysis of the TCT fading channel radio system. [Tone Calibrated Technique

    NASA Technical Reports Server (NTRS)

    Rafferty, William; Anderson, John B.; Saulnier, Gary J.; Holm, John R.

    1987-01-01

    This paper documents the laboratory and theoretical performance of a pilot-aided digital radio system. The technique considered transmits a midband pilot tone to improve the receiver data detection performance in a multipath fading channel and is referred to as the tone calibrated technique (TCT). The performance of a 860 MHz prototype system carrying 2.4 kbit/s data under Rician fading conditions is reported. Both experimental and analytical results show that the error floor experienced with nonpilot-aided transmission methods is effectively removed by the TCT scheme, resulting in significant performance gains at high signal-to-noise ratio values. The paper also examines the TCT system performance under typical operating conditions and presents a new analysis of the TCT theoretical error probability.

  20. MONSTIR II: A 32-channel, multispectral, time-resolved optical tomography system for neonatal brain imaging

    SciTech Connect

    Cooper, Robert J. Magee, Elliott; Everdell, Nick; Magazov, Salavat; Varela, Marta; Airantzis, Dimitrios; Gibson, Adam P.; Hebden, Jeremy C.

    2014-05-15

    We detail the design, construction and performance of the second generation UCL time-resolved optical tomography system, known as MONSTIR II. Intended primarily for the study of the newborn brain, the system employs 32 source fibres that sequentially transmit picosecond pulses of light at any four wavelengths between 650 and 900 nm. The 32 detector channels each contain an independent photo-multiplier tube and temporally correlated photon-counting electronics that allow the photon transit time between each source and each detector position to be measured with high temporal resolution. The system's response time, temporal stability, cross-talk, and spectral characteristics are reported. The efficacy of MONSTIR II is demonstrated by performing multi-spectral imaging of a simple phantom.

  1. An efficient system for reliably transmitting image and video data over low bit rate noisy channels

    NASA Technical Reports Server (NTRS)

    Costello, Daniel J., Jr.; Huang, Y. F.; Stevenson, Robert L.

    1994-01-01

    This research project is intended to develop an efficient system for reliably transmitting image and video data over low bit rate noisy channels. The basic ideas behind the proposed approach are the following: employ statistical-based image modeling to facilitate pre- and post-processing and error detection, use spare redundancy that the source compression did not remove to add robustness, and implement coded modulation to improve bandwidth efficiency and noise rejection. Over the last six months, progress has been made on various aspects of the project. Through our studies of the integrated system, a list-based iterative Trellis decoder has been developed. The decoder accepts feedback from a post-processor which can detect channel errors in the reconstructed image. The error detection is based on the Huber Markov random field image model for the compressed image. The compression scheme used here is that of JPEG (Joint Photographic Experts Group). Experiments were performed and the results are quite encouraging. The principal ideas here are extendable to other compression techniques. In addition, research was also performed on unequal error protection channel coding, subband vector quantization as a means of source coding, and post processing for reducing coding artifacts. Our studies on unequal error protection (UEP) coding for image transmission focused on examining the properties of the UEP capabilities of convolutional codes. The investigation of subband vector quantization employed a wavelet transform with special emphasis on exploiting interband redundancy. The outcome of this investigation included the development of three algorithms for subband vector quantization. The reduction of transform coding artifacts was studied with the aid of a non-Gaussian Markov random field model. This results in improved image decompression. These studies are summarized and the technical papers included in the appendices.

  2. Waterholes and their significance in the anastomosing channel system of Cooper Creek, Australia

    NASA Astrophysics Data System (ADS)

    Knighton, A. David; Nanson, Gerald C.

    1994-06-01

    Cooper Creek has developed a very extensive system of anastomosing channels, a distinctive feature of which is the preponderance of waterholes, which are readily identified as deepened and widened reaches of channel with more or less permanent water. They are widely distributed over the floodplain but tend to decrease in number downstream, possibly as a result of transmission losses which reduce erosive potential, and to develop preferentially towards the west, which has implications for the long-term relocation of the system. Classification of waterholes according to degree of lateral restriction and flow status reveals only muted contrasts in waterhole form between the various types. The one clear distinction is the unexpectedly low width/length ratio of the most restricted (dune-flanked) type, its squat form being attributable to erodible banks and limited downstream confinement. That waterholes have developed in abundance along Cooper Creek appears to be related to the presence of a more easily eroded sand sheet at depths of only 2-9 m below cohesive surface sediments. Sediment splays at their downstream ends indicate that waterholes can be maintained by the present regime but whether they were formed by that or a prior regime is a matter of debate. Some degree of inheritance cannot be discounted but a contemporary origin is favoured in view of the fact that most waterholes are located at points of flow convergence. By focusing erosional energy when the floodplain is extremely broad, waterholes play a significant role not only in maintaining existing channel lines but also in promoting the development of new ones, as the invasion of a dune field testifies.

  3. Channel nut tool

    DOEpatents

    Olson, Marvin

    2016-01-12

    A method, system, and apparatus for installing channel nuts includes a shank, a handle formed on a first end of a shank, and an end piece with a threaded shaft configured to receive a channel nut formed on the second end of the shaft. The tool can be used to insert or remove a channel nut in a channel framing system and then removed from the channel nut.

  4. The interaction between deepwater channel systems and growing thrusts and folds, toe-thrust region of the deepwater Niger Delta

    NASA Astrophysics Data System (ADS)

    Jolly, Byami; Whittaker, Alex; Lonergan, Lidia

    2015-04-01

    Gravity-driven seaward-verging thrusts, landward-verging back-thrusts and associated folds often characterize the slope and deepwater settings of passive margins. These structures, found in the 'toe-thrust' region of the system, exert a significant control on sediment gravity flows because they create and determine the location and configuration of sediment depocentres and transport systems. Consequently, a quantitative understanding of the interaction between sediment gravity flows and seabed topography is required to understand these systems effectively. Here we make quantitative measurements of the geomorphic response of submarine channels to growing tectonic structures with the aim of providing new constraints on the long-term erosional dynamics of submarine channel systems. This study exploits 3D seismic data in the outer toe-thrust region of the deepwater Niger Delta to analyze the interaction between Plio-Pleistocene channel systems and actively growing folds and thrusts. We mapped folds and thrusts from the seismic data and we used this data to reconstruct the history of fold growth. We then used the sea-bed seismic horizon to build a 50 m resolution Digital Elevation Model (DEM) of the sea floor in Arc-GIS. We extracted channel long- profiles across growing structures from the DEM, and made measurements of channel geometries at regular intervals along the channel length. This information was used to infer morphodyanamic processes that sculpted the channel systems through time, and to estimate the bed shear stresses and fluid velocities of typical flow events. The bathymetric long profiles of these channels are relatively linear with concavity that range from -0.08 to -0.34, and an average gradient of ~1o. Actively growing thrusts are typically associated with a local steepening in channel gradient by a factor of up to 3, and this effect extends 0.5 - 2 km upstream of the thrust. Within these knickzones, channel incision increases by approximately by a

  5. The late Cenozoic deep-water channel system in the Baiyun Sag, Pearl River Mouth Basin: Development and tectonic effects

    NASA Astrophysics Data System (ADS)

    Ma, Benjun; Wu, Shiguo; Sun, Qiliang; Mi, Lijun; Wang, ZhenZhen; Tian, Jie

    2015-12-01

    Twenty modern submarine channels and buried channels were examined using high-resolution 3D/2D seismic data in the Baiyun Sag, Pearl River Mouth Basin. The channels were dominantly straight, sub-parallel with one another, and oriented perpendicular to the slope contours. Four stages of the deep-water channel system (DCS) were identified according to seismic facies and spatial distribution. The stages were controlled by sediment input and tectonic activities. DCS I is distributed in the middle of the Baiyun Sag, with small individual channels. DCS II expanded because of decreasing sediment input and stable subsidence of the Baiyun Sag increased the slope. DCS III had the broadest distribution and nearly covered the entire Baiyun Sag. Further decreases in sediment input and the Dongsha Event increased the gravity flow domain and greatly promoted the development of the DCS. DCS IV narrowed to the southwest because the buried channels in the northeastern Baiyun Sag ceased after 5.5 Ma as the result of active fault activity. This study highlights that the channel system plays an important role in recording the sedimentary evolution of the Pearl River Mouth Basin and affects the deep-water resource (hydrocarbon and gas hydrate) distribution.

  6. Ultrafast STR Separations on Short-Channel Microfluidic Systems for Forensic Screening and Genotyping.

    PubMed

    Aboud, Maurice J; Gassmann, Marcus; McCord, Bruce

    2015-09-01

    There are situations in which it is important to quickly and positively identify an individual. Examples include suspects detained in the neighborhood of a bombing or terrorist incident, individuals detained attempting to enter or leave the country, and victims of mass disasters. Systems utilized for these purposes must be fast, portable, and easy to maintain. DNA typing methods provide the best biometric information yielding identity, kinship, and geographical origin, but they are not portable and rapid. This study details the development of a portable short-channel microfluidic device based on a modified Agilent 2100 bioanalyzer for applications in forensic genomics. The system utilizes a denaturing polymer matrix with dual-channel laser-induced fluorescence and is capable of producing a genotype in 80 sec. The device was tested for precision and resolution using an allelic ladder created from 6 short tandem repeat (STR) loci and a sex marker (amelogenin). The results demonstrated a precision of 0.09-0.21 bp over the entire size range and resolution values from 2.5 to 4.1 bp. Overall, the results demonstrate the chip provides a portable, rapid, and precise method for screening amplified short tandem repeats and human identification screening. PMID:26280913

  7. Comparison of Cell Expression Formats for the Characterization of GABAA Channels Using a Microfluidic Patch Clamp System

    PubMed Central

    Chen, Qin; Yim, Peter D.; Yuan, Nina; Johnson, Juliette; Cook, James M.; Smith, Steve; Ionescu-Zanetti, Cristian; Wang, Zhi-Jian; Arnold, Leggy A.

    2012-01-01

    Abstract Ensemble recording and microfluidic perfusion are recently introduced techniques aimed at removing the laborious nature and low recording success rates of manual patch clamp. Here, we present assay characteristics for these features integrated into one automated electrophysiology platform as applied to the study of GABAA channels. A variety of cell types and methods of GABAA channel expression were successfully studied (defined as IGABA>500 pA), including stably transfected human embryonic kidney (HEK) cells expressing α1β3γ2 GABAA channels, frozen ready-to-assay (RTA) HEK cells expressing α1β3γ2 or α3β3γ2 GABAA channels, transiently transfected HEK293T cells expressing α1β3γ2 GABAA channels, and immortalized cultures of human airway smooth muscle cells endogenously expressing GABAA channels. Current measurements were successfully studied in multiple cell types with multiple modes of channel expression in response to several classic GABAA channel agonists, antagonists, and allosteric modulators. We obtained success rates above 95% for transiently or stably transfected HEK cells and frozen RTA HEK cells expressing GABAA channels. Tissue-derived immortalized cultures of airway smooth muscle cells exhibited a slightly lower recording success rate of 75% using automated patch, which was much higher than the 5% success rate using manual patch clamp technique by the same research group. Responses to agonists, antagonists, and allosteric modulators compared well to previously reported manual patch results. The data demonstrate that both the biophysics and pharmacologic characterization of GABAA channels in a wide variety of cell formats can be performed using this automated patch clamp system. PMID:22574655

  8. SER Analysis of MPPM-Coded MIMO-FSO System over Uncorrelated and Correlated Gamma-Gamma Atmospheric Turbulence Channels

    NASA Astrophysics Data System (ADS)

    Khallaf, Haitham S.; Garrido-Balsells, José M.; Shalaby, Hossam M. H.; Sampei, Seiichi

    2015-12-01

    The performance of multiple-input multiple-output free space optical (MIMO-FSO) communication systems, that adopt multipulse pulse position modulation (MPPM) techniques, is analyzed. Both exact and approximate symbol-error rates (SERs) are derived for both cases of uncorrelated and correlated channels. The effects of background noise, receiver shot-noise, and atmospheric turbulence are taken into consideration in our analysis. The random fluctuations of the received optical irradiance, produced by the atmospheric turbulence, is modeled by the widely used gamma-gamma statistical distribution. Uncorrelated MIMO channels are modeled by the α-μ distribution. A closed-form expression for the probability density function of the optical received irradiance is derived for the case of correlated MIMO channels. Using our analytical expressions, the degradation of the system performance with the increment of the correlation coefficients between MIMO channels is corroborated.

  9. Terrestrial analogs to lunar sinuous rilles - Kauhako Crater and channel, Kalaupapa, Molokai, and other Hawaiian lava conduit systems

    NASA Technical Reports Server (NTRS)

    Coombs, C. R.; Hawke, B. R.; Wilson, L.

    1990-01-01

    Two source vents, one explosive and one effusive erupted to form a cinder cone and low lava shield that together compose the Kalaupapa peninsula of Molokai, Hawaii, A 50-100-m-wide channel/tube system extends 2.3 km northward from kauhako crater in the center of the shield. Based on modeling, a volume of up to about 0.2 cu km of lava erupted at a rate of 260 cu m/sec to flow through the Kauhako conduit system in one of the last eruptive episodes on the peninsula. Channel downcutting by thermal erosion occurred at a rate of about 10 micron/sec to help form the 30-m-deep conduit. Two smaller, secondary tube systems formed east of the main lava channel/tube. Several other lava conduit systems on the islands of Oahu and Hawaii were also compared to the Kauhako and lunar sinuous rille systems. These other lava conduits include Whittington, Kupaianaha, and Mauna Ulu lava tubes. Morphologically, the Hawaiian tube systems studied are very similar to lunar sinuous rilles in that they have deep head craters, sinuous channels, and gentle slopes. Thermal erosion is postulated to be an important factor in the formation of these terrestrial channel systems and by analogy is inferred to be an important process involved in the formation of lunar sinuous rilles.

  10. SER performance analysis of MPPM FSO system with three decision thresholds over exponentiated Weibull fading channels

    NASA Astrophysics Data System (ADS)

    Wang, Ping; Yang, Bensheng; Guo, Lixin; Shang, Tao

    2015-11-01

    In this work, the symbol error rate (SER) performance of the multiple pulse position modulation (MPPM) based free-space optical communication (FSO) system with three different decision thresholds, fixed decision threshold (FDT), optimized decision threshold (ODT) and dynamic decision threshold (DDT) over exponentiated Weibull (EW) fading channels has been investigated in detail. The effects of aperture averaging on each decision threshold under weak-to-strong turbulence conditions are further studied and compared. The closed-form SER expressions for three thresholds derived with the help of generalized Gauss-Laguerre quadrature rule are verified by the Monte Carlo simulations. This work is helpful for the design of receivers for FSO communication systems.

  11. Application of a four-channel vibrometer system for detection of arterial stiffness

    NASA Astrophysics Data System (ADS)

    Campo, Adriaan; Waz, Adam; Dudzik, Grzegorz; Dirckx, Joris; Abramski, Krzysztof

    2016-06-01

    Cardiovascular diseases (CD) are the most important cause of death in the world and their prevalence is only rising. A significant aspect in the etiology of CD is the stiffening of the large arteries (arteriosclerosis) and plaque formation (atherosclerosis) in the common carotid artery (CCA) in the neck. As shown by increasing evidence, both conditions can be detected by assessing pulse wave velocity (PWV) in the CCA, and several approaches allow local detection of PWV, including ultrasound (US) and magnetic resonance imaging (MRI). In previous studies, laser Doppler vibrometry (LDV) was introduced as an approach to assess arterial stiffness. In the present work, a new, compact four-channel LDV system is used for PWV detection in four phantom arteries mimicking real life CCA conditions. The high sensitivity of the LDV system allowed PWV to be assessed, and even local changes in phantom architecture could be detected. This method has potential for cardiovascular screening, as it allows arteriosclerosis assessment and plaque detection.

  12. Cochannel and Adjacent-Channel Interference in Nonlinear Minimum-Shift-Keyed Satellite System

    NASA Technical Reports Server (NTRS)

    Yu, John

    1995-01-01

    The interference susceptibility of a serial-minimum-shift-keyed (SMSK) modulation system to an interfering signal transmitted through a satellite link with cascaded nonlinear elements was investigated through computer simulation. The satellite link evaluated in this study represented NASA's Advanced Communications Technology Satellite (ACTS) system. Specifically, nonlinear characteristics were used that had specified amplitude-modulation to amplitude-modulation and amplitude-modulation to phase-modulation transfer characteristics obtained from the actual ACTS hardware. Two measurement scenarios were analyzed: degradation of an MSK satellite link from cochannel interference and from adjacent-channel interference. Interference was evaluated in terms of the probability of bit error rate (BER) versus energy per bit over noise power density Eb/No.

  13. SINR Analysis of Hexagonal Multicarrier Transmission Systems in the Presence of Insufficient Synchronization for Doubly Dispersive Channel

    NASA Astrophysics Data System (ADS)

    Xu, Kui; Xu, Youyun; Zhang, Dongmei

    2011-07-01

    This paper analyzes the effect of the insufficient synchronization (carrier frequency offset, timing offset) on hexagonal multicarrier transmission (HMT) systems for doubly dispersive channel. Exact SINR and demodulated symbol expressions for HMT systems in the presence of insufficient synchronization transmission conditions over doubly dispersive channel with exponential delay power profile and U-shape Doppler power spectrum and uniform delay power profile and uniform Doppler power spectrum are derived, respectively. Theoretical analysis shows that similar degradations on symbol amplitude and phase caused by insufficient synchronization are incurred as in traditional cyclic-prefix orthogonal frequency division multiplexing (CP-OFDM) transmission. HMT systems outperform traditional OFDM systems with respect to signal to interference-plus-noise-ratio (SINR) against inter-symbol interference (ISI) and inter-carrier interference (ICI) caused by insufficient synchronization and doubly dispersive(DD) channel. The BER performance of the HMT systems using Monte Carlo simulation match with the conclusion given by the proposed exact SINR expression.

  14. Morphology of Red Creek, Wyoming, an arid-region anastomosing channel system

    USGS Publications Warehouse

    Schumann, R.R.

    1989-01-01

    The narrow, deep, and sinuous main channel is flanked by anastomosing flood channels, or anabranches. Most anabranches are initiated at meander bends. The primary mechanism of anabranch initiation is avulsion during overbank floods. -from Author

  15. A comprehensive study of channel estimation for WBAN-based healthcare systems: feasibility of using multiband UWB.

    PubMed

    Islam, S M Riazul; Kwak, Kyung Sup

    2012-06-01

    Wireless personal area network (WPAN) is an emerging in wireless technology for short range indoor and outdoor communication applications. A more specific category of WPAN is the wireless body area network (WBAN) used for health monitoring. On the other hand, multiband orthogonal frequency division multiplexing (MB-OFDM) ultra-wideband (UWB) comes with a number of desirable features at the physical layer for wireless communications, for example, very high data rate. One big challenge in adoption of multiband UWB in WBAN is the fact that channel estimation becomes difficult under the constraint of extremely low transmission power. Moreover, the heterogeneous environment of WBAN causes a dense multipath wireless channel. Therefore, effective channel estimation is required in the receiver of WBAN-based healthcare system that uses multiband UWB. In this paper, we first outline the MB-OFDM UWB system. Then, we present an overview of channel estimation techniques proposed/investigated for multiband UWB communications with emphasis on their strengths and weaknesses. Useful suggestions are given to overcome the weaknesses so that these methods can be particularly useful for WBAN channels. Also, we analyze the comparative performances of the techniques using computer simulation in order to find the energy-efficient channel estimation methods for WBAN-based healthcare systems.

  16. Security-reliability performance of cognitive AF relay-based wireless communication system with channel estimation error

    NASA Astrophysics Data System (ADS)

    Gu, Qi; Wang, Gongpu; Gao, Li; Peng, Mugen

    2014-12-01

    In this paper, both the security and the reliability performance of the cognitive amplify-and-forward (AF) relay system are analyzed in the presence of the channel estimation error. The security and the reliability performance are represented by the outage probability and the intercept probability, respectively. Instead of perfect channel state information (CSI) predominantly assumed in the literature, a certain channel estimation algorithm and the influence of the corresponding channel estimation error are considered in this study. Specifically, linear minimum mean square error estimation (LMMSE) is utilized by the destination node and the eavesdropper node to obtain the CSI, and the closed form for the outage probability and that for the intercept probability are derived with the channel estimation error. It is shown that the transmission security (reliability) can be improved by loosening the reliability (security) requirement. Moreover, we compare the security and reliability performance of this relay-based cognitive radio system with those of the direct communication system without relay. Interestingly, it is found that the AF relay-based system has less reliability performance than the direct cognitive radio system; however, it can lower the sum of the outage probability and the intercept probability than the direct communication system. It is also found that there exists an optimal training number to minimize the sum of the outage probability and the intercept probability.

  17. A Wireless Multi-Channel Recording System for Freely Behaving Mice and Rats

    PubMed Central

    Holtzman, Tahl; Ruther, Patrick; Dalley, Jeffrey W.; Lopez, Alberto; Rossi, Mark A.; Barter, Joseph W.; Salas-Meza, Daniel; Herwik, Stanislav; Holzhammer, Tobias; Morizio, James; Yin, Henry H.

    2011-01-01

    To understand the neural basis of behavior, it is necessary to record brain activity in freely moving animals. Advances in implantable multi-electrode array technology have enabled researchers to record the activity of neuronal ensembles from multiple brain regions. The full potential of this approach is currently limited by reliance on cable tethers, with bundles of wires connecting the implanted electrodes to the data acquisition system while impeding the natural behavior of the animal. To overcome these limitations, here we introduce a multi-channel wireless headstage system designed for small animals such as rats and mice. A variety of single unit and local field potential signals were recorded from the dorsal striatum and substantia nigra in mice and the ventral striatum and prefrontal cortex simultaneously in rats. This wireless system could be interfaced with commercially available data acquisition systems, and the signals obtained were comparable in quality to those acquired using cable tethers. On account of its small size, light weight, and rechargeable battery, this wireless headstage system is suitable for studying the neural basis of natural behavior, eliminating the need for wires, commutators, and other limitations associated with traditional tethered recording systems. PMID:21765934

  18. Sodium channel kinetic changes that produce Brugada syndrome or progressive cardiac conduction system disease.

    PubMed

    Zhang, Zhu-Shan; Tranquillo, Joseph; Neplioueva, Valentina; Bursac, Nenad; Grant, Augustus O

    2007-01-01

    Some mutations of the sodium channel gene Na(V1.5) are multifunctional, causing combinations of LQTS, Brugada syndrome and progressive cardiac conduction system disease (PCCD). The combination of Brugada syndrome and PCCD is uncommon, although they both result from a reduction in the sodium current. We hypothesize that slow conduction is sufficient to cause S-T segment elevation and undertook a combined experimental and theoretical study to determine whether conduction slowing alone can produce the Brugada phenotype. Deletion of lysine 1479 in one of two positively charged clusters in the III/IV inter-domain linker causes both syndromes. We have examined the functional effects of this mutation using heterologous expression of the wild-type and mutant sodium channel in HEK-293-EBNA cells. We show that DeltaK1479 shifts the potential of half-activation, V(1/2m), to more positive potentials (V(1/2m) = -36.8 +/- 0.8 and -24.5 +/- 1.3 mV for the wild-type and DeltaK1479 mutant respectively, n = 11, 10). The depolarizing shift increases the extent of depolarization required for activation. The potential of half-inactivation, V(1/2h), is also shifted to more positive potentials (V(1/2h) = -85 +/- 1.1 and -79.4 +/- 1.2 mV for wild-type and DeltaK1479 mutant respectively), increasing the fraction of channels available for activation. These shifts are quantitatively the same as a mutation that produces PCCD only, G514C. We incorporated experimentally derived parameters into a model of the cardiac action potential and its propagation in a one dimensional cable (simulating endo-, mid-myocardial and epicardial regions). The simulations show that action potential and ECG changes consistent with Brugada syndrome may result from conduction slowing alone; marked repolarization heterogeneity is not required. The findings also suggest how Brugada syndrome and PCCD which both result from loss of sodium channel function are sometimes present alone and at other times in combination

  19. Multimodal signal integration in the nervous system: from ion channels to neurons to networks - and reverse.

    NASA Astrophysics Data System (ADS)

    Braun, Hans Albert

    2005-03-01

    Signal encoding in single neurons and neuronal nets can drastically change depending on their actual dynamical state. Dynamic state transitions are of particular relevance when different types of signals have to be simultaneously integrated because each signal can modify the transduction characteristics of each other signal due to the system's inherent non-linearities. Nonlinear, multimodal signal encoding can already be seen at the single neuron level [Braun et al. 1994, Nature 367: 270-273] and is an essential characteristic of integrative brain functions [Wollweber et al. 2004, J Thermal Biol, 29: 345-350]. However, signal encoding and neuromodulation takes place at a still lower level, namely by alterations of voltage- or ligand-gated ion channels. Nevertheless, to avoid an overwhelming complexity, the dynamics at the lower levels are often neglected when higher levels are examined, e.g. neuronal network analysis generally does not consider the details of ion channel gating. Hodgkin-Huxley type computer simulations shall elucidate which simplifications can be made without loss of essential functional properties and which state transitions at lower levels can become of functional relevance for the higher level dynamics [Sosnovtseva et al. 2004, FNL 4:L521-L533].

  20. Stratigraphic evolution of a long-lived submarine channel system in the Late Cretaceous Nanaimo Group, British Columbia, Canada

    NASA Astrophysics Data System (ADS)

    Bain, Heather A.; Hubbard, Stephen M.

    2016-05-01

    Submarine canyons and slope channel systems are important conveyers of sediment from uplifted catchments to oceanic sedimentary sinks. Long-lived conduits can be established through deep incision of submarine canyons, with bathymetric relief of hundreds of meters to greater than a kilometer in many instances. Alternatively, a combination of erosion of the continental slope and aggradation of levees can yield a broadly comparable stratigraphic product through evolution of channels with more subdued bathymetric relief. Despite differences in formative geomorphic elements on the paleo-seafloor, differentiating the stratigraphic architecture amongst these systems is challenging, particularly in outcrop datasets. Accurate stratigraphic interpretation has significant implications for understanding the frequency and magnitude of controlling processes such as mountain building and denudation or eustatic sea-level fluctuations. In this study, deep-water channel strata of the Late Cretaceous Nanaimo Group are examined at Hornby and Denman islands, British Columbia, Canada. Evidence for a long-lived submarine conduit records the history of sediment transfer at multiple temporal and spatial scales. The composite submarine channel system deposit is 19.5 km wide and 1500 m thick, which formed and filled over ~ 15 Ma. Facies scale analyses highlight conglomeratic channel fill juxtaposed against thin-bedded out-of-channel deposits. Erosional surfaces are commonly mantled by mass-transport deposits, which provide evidence for conduit wall reworking and maintenance. At a larger scale, a series of composite, conglomerate-prone channelform bodies are observed to stratigraphically stack in two distinct phases: (1) early persistence of laterally offset (migrated) channels; and (2) later vertically aligned and aggraded channels. This stratigraphic trend is comparable to composite, multi-phase degradational-aggradational submarine channel complexes observed globally. As such, we consider

  1. Constraining the erosional response of deep-water channel systems to growing folds and thrusts, Niger Delta.

    NASA Astrophysics Data System (ADS)

    Whittaker, A. C.; Lonergan, L.; Jolly, B. A.

    2015-12-01

    Gravity-driven folds and thrusts often characterize the slope and deep-water settings of passive margins. These structures exert a significant control on sediment gravity flows because they determine the location and configuration of sediment depo-centres and transport systems. Here we exploit 3D seismic data in the outer toe-thrust region of the deep-water Niger Delta to analyse the interaction between Plio-Pleistocene channel systems and actively-growing folds and thrusts. We first map folds and thrusts from the seismic data and we use this data to reconstruct the history of fold growth in detail. We then make quantitative measurements of the geomorphic response of submarine channels to growing tectonic structures in order to provide new constraints on their long-term erosional dynamics. This information is used to infer morphodyanamic processes that sculpted the channel systems through time, and to estimate the bed shear stresses and fluid velocities of typical flow events. The bathymetric long profiles of these channels have concavities that range from -0.08 to -0.34, and an average gradient of ~1o. Thrusts are associated with a local steepening in channel gradient of up to 3 times, and this effect extends 0.5 - 2 km upstream of the thrust. Within these knickzones, channel incision increases by approximately by a factor of 2, with a corresponding width decrease of approximately 25%. Channel incision across growing structures is achieved through enhanced bed-shear stress driven incision (up to 200 Pa) and flow velocity (up to 5 ms-1) assuming typical bulk sediment concentrations of 0.6%. Comparison of structural uplift since 1.7 Ma, and channel incision over an equivalent period, shows that many of these channels are able to keep pace with the time-integrated uplift since 1.7 Ma, and may have reached a bathymetric steady-state. Generally, bed-shear stresses of ~150 Pa are sufficient to keep pace with structural strain rates of 10-15 s-1. More widely, our data

  2. Automated higher-throughput compound screening on ion channel targets based on the Xenopus laevis oocyte expression system.

    PubMed

    Pehl, Ulrich; Leisgen, Christine; Gampe, Kristine; Guenther, Elke

    2004-10-01

    As numerous diseases have been shown to be related to dysfunction of ion channels and neurotransmitter receptors and to affect regulatory pathways, ion channels have attracted increasing attention as a target class for drug discovery. The concomitant demand of the pharmaceutical industry for adequate electrophysiological methods to investigate drug effects on specific ion channels in secondary and safety screening has resulted in the development of electrophysiological instrumentation that allows automated monitoring of ion channel function with a higher throughput. Here we tested a fully automated screening system based on the Xenopus laevis oocyte expression system. We addressed the questions of data quality and reproducibility obtained by automated oocyte injection and two-electrode voltage-clamp (TEVC) recording using the Roboocyte (Multi Channel Systems GmbH, Reutlingen, Germany) technology compared to conventional oocyte recording. A gamma-aminobutyric acid (GABA)A-receptor subtype (alpha(1)beta(2)) was chosen as an example for a ligand-gated ion channel, and the slowly activating potassium current I(Ks) as a voltage-activated ion channel. Oocytes were injected with cDNA or cRNA via the Roboocyte injection stage. Ion channel currents were successfully recorded after 2-7 days in about 40% of the oocytes injected with GABA(A) receptor cDNA, and after 2-4 days in about 60% of the oocytes injected with KCNE1 cRNA. EC(50) values for the GABA(A) receptor and IC(50) values for blockers of I(Ks) were comparable to values obtained with conventional TEVC recording techniques. In conclusion, our results show that the Roboocyte is a valuable automated tool for oocyte injection and TEVC recording that can be used in drug screening and target validation to enhance the number of compounds and oocytes tested per day.

  3. Design of a 32-Channel EEG System for Brain Control Interface Applications

    PubMed Central

    Wang, Ching-Sung

    2012-01-01

    This study integrates the hardware circuit design and the development support of the software interface to achieve a 32-channel EEG system for BCI applications. Since the EEG signals of human bodies are generally very weak, in addition to preventing noise interference, it also requires avoiding the waveform distortion as well as waveform offset and so on; therefore, the design of a preamplifier with high common-mode rejection ratio and high signal-to-noise ratio is very important. Moreover, the friction between the electrode pads and the skin as well as the design of dual power supply will generate DC bias which affects the measurement signals. For this reason, this study specially designs an improved single-power AC-coupled circuit, which effectively reduces the DC bias and improves the error caused by the effects of part errors. At the same time, the digital way is applied to design the adjustable amplification and filter function, which can design for different EEG frequency bands. For the analog circuit, a frequency band will be taken out through the filtering circuit and then the digital filtering design will be used to adjust the extracted frequency band for the target frequency band, combining with MATLAB to design man-machine interface for displaying brain wave. Finally the measured signals are compared to the traditional 32-channel EEG signals. In addition to meeting the IFCN standards, the system design also conducted measurement verification in the standard EEG isolation room in order to demonstrate the accuracy and reliability of this system design. PMID:22778545

  4. Shannon information capacity of time reversal wideband multiple-input multiple-output system based on correlated statistical channels

    NASA Astrophysics Data System (ADS)

    Yu, Yang; Bing-Zhong, Wang; Shuai, Ding

    2016-05-01

    Utilizing channel reciprocity, time reversal (TR) technique increases the signal-to-noise ratio (SNR) at the receiver with very low transmitter complexity in complex multipath environment. Present research works about TR multiple-input multiple-output (MIMO) communication all focus on the system implementation and network building. The aim of this work is to analyze the influence of antenna coupling on the capacity of wideband TR MIMO system, which is a realistic question in designing a practical communication system. It turns out that antenna coupling stabilizes the capacity in a small variation range with statistical wideband channel response. Meanwhile, antenna coupling only causes a slight detriment to the channel capacity in a wideband TR MIMO system. Comparatively, uncorrelated stochastic channels without coupling exhibit a wider range of random capacity distribution which greatly depends on the statistical channel. The conclusions drawn from information difference entropy theory provide a guideline for designing better high-performance wideband TR MIMO communication systems. Project supported by the National Natural Science Foundation of China (Grant Nos. 61331007, 61361166008, and 61401065) and the Specialized Research Fund for the Doctoral Program of Higher Education of China (Grant No. 20120185130001).

  5. A New, Scalable and Low Cost Multi-Channel Monitoring System for Polymer Electrolyte Fuel Cells.

    PubMed

    Calderón, Antonio José; González, Isaías; Calderón, Manuel; Segura, Francisca; Andújar, José Manuel

    2016-01-01

    In this work a new, scalable and low cost multi-channel monitoring system for Polymer Electrolyte Fuel Cells (PEFCs) has been designed, constructed and experimentally validated. This developed monitoring system performs non-intrusive voltage measurement of each individual cell of a PEFC stack and it is scalable, in the sense that it is capable to carry out measurements in stacks from 1 to 120 cells (from watts to kilowatts). The developed system comprises two main subsystems: hardware devoted to data acquisition (DAQ) and software devoted to real-time monitoring. The DAQ subsystem is based on the low-cost open-source platform Arduino and the real-time monitoring subsystem has been developed using the high-level graphical language NI LabVIEW. Such integration can be considered a novelty in scientific literature for PEFC monitoring systems. An original amplifying and multiplexing board has been designed to increase the Arduino input port availability. Data storage and real-time monitoring have been performed with an easy-to-use interface. Graphical and numerical visualization allows a continuous tracking of cell voltage. Scalability, flexibility, easy-to-use, versatility and low cost are the main features of the proposed approach. The system is described and experimental results are presented. These results demonstrate its suitability to monitor the voltage in a PEFC at cell level. PMID:27005630

  6. A New, Scalable and Low Cost Multi-Channel Monitoring System for Polymer Electrolyte Fuel Cells

    PubMed Central

    Calderón, Antonio José; González, Isaías; Calderón, Manuel; Segura, Francisca; Andújar, José Manuel

    2016-01-01

    In this work a new, scalable and low cost multi-channel monitoring system for Polymer Electrolyte Fuel Cells (PEFCs) has been designed, constructed and experimentally validated. This developed monitoring system performs non-intrusive voltage measurement of each individual cell of a PEFC stack and it is scalable, in the sense that it is capable to carry out measurements in stacks from 1 to 120 cells (from watts to kilowatts). The developed system comprises two main subsystems: hardware devoted to data acquisition (DAQ) and software devoted to real-time monitoring. The DAQ subsystem is based on the low-cost open-source platform Arduino and the real-time monitoring subsystem has been developed using the high-level graphical language NI LabVIEW. Such integration can be considered a novelty in scientific literature for PEFC monitoring systems. An original amplifying and multiplexing board has been designed to increase the Arduino input port availability. Data storage and real-time monitoring have been performed with an easy-to-use interface. Graphical and numerical visualization allows a continuous tracking of cell voltage. Scalability, flexibility, easy-to-use, versatility and low cost are the main features of the proposed approach. The system is described and experimental results are presented. These results demonstrate its suitability to monitor the voltage in a PEFC at cell level. PMID:27005630

  7. Design and application of 8-channel SOI-based AWG demultiplexer for CWDM-system

    SciTech Connect

    Juhari, Nurjuliana; Menon, P. Susthitha; Ehsan, Abang Annuar; Shaari, Sahbudin

    2015-04-24

    Arrayed Waveguide Grating (AWG) serving as a demultiplexer (demux) has been designed on SOI platform and was utilized in a Coarse Wavelength Division Multiplexing (CWDM) system ranging from 1471 nm to 1611 nm. The investigation was carried out at device and system levels. At device level, 20 nm (∼ 2500 GHz) channel spacing was successfully simulated using beam propagation method (BPM) under TE mode polarization with a unique double S-shape pattern at arrays region. The performance of optical properties gave the low values of 0.96 dB dB for insertion loss and – 22.38 dB for optical crosstalk. AWG device was then successfully used as demultiplexer in CWDM system when 10 Gb/s data rate was applied in the system. Limitation of signal power due to attenuation and fiber dispersion detected by BER analyzer =10{sup −9} of the system was compared with theoretical value. Hence, the maximum distance of optical fiber can be achieved.

  8. Design and application of 8-channel SOI-based AWG demultiplexer for CWDM-system

    NASA Astrophysics Data System (ADS)

    Juhari, Nurjuliana; Menon, P. Susthitha; Ehsan, Abang Annuar; Shaari, Sahbudin

    2015-04-01

    Arrayed Waveguide Grating (AWG) serving as a demultiplexer (demux) has been designed on SOI platform and was utilized in a Coarse Wavelength Division Multiplexing (CWDM) system ranging from 1471 nm to 1611 nm. The investigation was carried out at device and system levels. At device level, 20 nm (˜ 2500 GHz) channel spacing was successfully simulated using beam propagation method (BPM) under TE mode polarization with a unique double S-shape pattern at arrays region. The performance of optical properties gave the low values of 0.96 dB dB for insertion loss and - 22.38 dB for optical crosstalk. AWG device was then successfully used as demultiplexer in CWDM system when 10 Gb/s data rate was applied in the system. Limitation of signal power due to attenuation and fiber dispersion detected by BER analyzer =10-9 of the system was compared with theoretical value. Hence, the maximum distance of optical fiber can be achieved.

  9. A New, Scalable and Low Cost Multi-Channel Monitoring System for Polymer Electrolyte Fuel Cells.

    PubMed

    Calderón, Antonio José; González, Isaías; Calderón, Manuel; Segura, Francisca; Andújar, José Manuel

    2016-03-09

    In this work a new, scalable and low cost multi-channel monitoring system for Polymer Electrolyte Fuel Cells (PEFCs) has been designed, constructed and experimentally validated. This developed monitoring system performs non-intrusive voltage measurement of each individual cell of a PEFC stack and it is scalable, in the sense that it is capable to carry out measurements in stacks from 1 to 120 cells (from watts to kilowatts). The developed system comprises two main subsystems: hardware devoted to data acquisition (DAQ) and software devoted to real-time monitoring. The DAQ subsystem is based on the low-cost open-source platform Arduino and the real-time monitoring subsystem has been developed using the high-level graphical language NI LabVIEW. Such integration can be considered a novelty in scientific literature for PEFC monitoring systems. An original amplifying and multiplexing board has been designed to increase the Arduino input port availability. Data storage and real-time monitoring have been performed with an easy-to-use interface. Graphical and numerical visualization allows a continuous tracking of cell voltage. Scalability, flexibility, easy-to-use, versatility and low cost are the main features of the proposed approach. The system is described and experimental results are presented. These results demonstrate its suitability to monitor the voltage in a PEFC at cell level.

  10. Wireless Channel Characterization: Modeling the 5 GHz Microwave Landing System Extension Band for Future Airport Surface Communications

    NASA Technical Reports Server (NTRS)

    Matolak, D. W.; Apaza, Rafael; Foore, Lawrence R.

    2006-01-01

    We describe a recently completed wideband wireless channel characterization project for the 5 GHz Microwave Landing System (MLS) extension band, for airport surface areas. This work included mobile measurements at large and small airports, and fixed point-to-point measurements. Mobile measurements were made via transmission from the air traffic control tower (ATCT), or from an airport field site (AFS), to a receiving ground vehicle on the airport surface. The point-to-point measurements were between ATCT and AFSs. Detailed statistical channel models were developed from all these measurements. Measured quantities include propagation path loss and power delay profiles, from which we obtain delay spreads, frequency domain correlation (coherence bandwidths), fading amplitude statistics, and channel parameter correlations. In this paper we review the project motivation, measurement coordination, and illustrate measurement results. Example channel modeling results for several propagation conditions are also provided, highlighting new findings.

  11. Semi-analytic modeling of FWM noise in dispersion-managed DWDM systems with DQPSK/DPSK/OOK channels

    NASA Astrophysics Data System (ADS)

    Du, Jianxin; Teng, Zhiyu; Shen, Ninghang

    2016-01-01

    Semi-analytic models are developed to deterministically calculate the variances of degenerate and non-degenerate four-wave-mixing (FWM) noises for dispersion-managed dense wavelength division multiplexing (DWDM) systems with pure and mixed differential quadrature-phase-shift keying (DQPSK)/differential phase-shift keying (DPSK)/on-off-keying (OOK) channels. The semi-analytic models include various important propagation effects for exact numerical results. The novel dispersion map used here for dispersion management is composed of effective-area-enlarged positive dispersion fiber (EE-PDF), dispersion slope and dispersion compensating fiber (SCDCF) and nonzero dispersion-shifted fiber (NZ-DSF). It is numerically validated with the new models that, under the condition that all channels have the same average launch powers and baud rates, the impact of FWM noise for mixed DQPSK/OOK channels are more severe than that for pure DQPSK and mixed DQPSK/DPSK channels. It is also shown that the FWM efficiency is strongly dependent on the peak power of launched optical pulse for a large number of channels, as can be mainly attributed to the quasi-linear evolution of pulse shapes in pump channels induced by cross-phase modulation (XPM). Compared with some commercial optical-fiber transmission simulators, massive time-consuming can be avoided by using the newly derived semi-analytic models when transmission performances of such DWDM systems are numerically optimized and evaluated.

  12. Diacetin, a reliable cue and private communication channel in a specialized pollination system

    PubMed Central

    Schäffler, Irmgard; Steiner, Kim E.; Haid, Mark; van Berkel, Sander S.; Gerlach, Günter; Johnson, Steven D.; Wessjohann, Ludger; Dötterl, Stefan

    2015-01-01

    The interaction between floral oil secreting plants and oil-collecting bees is one of the most specialized of all pollination mutualisms. Yet, the specific stimuli used by the bees to locate their host flowers have remained elusive. This study identifies diacetin, a volatile acetylated glycerol, as a floral signal compound shared by unrelated oil plants from around the globe. Electrophysiological measurements of antennae and behavioural assays identified diacetin as the key volatile used by oil-collecting bees to locate their host flowers. Furthermore, electrophysiological measurements indicate that only oil-collecting bees are capable of detecting diacetin. The structural and obvious biosynthetic similarity between diacetin and associated floral oils make it a reliable cue for oil-collecting bees. It is easily perceived by oil bees, but can’t be detected by other potential pollinators. Therefore, diacetin represents the first demonstrated private communication channel in a pollination system. PMID:26245141

  13. COMPONENTS OF LASER SYSTEMS: Single-channel adaptive mirrors for laser optics

    NASA Astrophysics Data System (ADS)

    Safronov, A. G.

    1995-11-01

    Single-channel deformable mirrors for use in low-correction-order laser adaptive systems were developed and investigated. The structure of the mirrors is described and the results are given of experimental determinations of the initial shape of the optical surface, of the response functions, of the sensitivity, and of the electromechanical hysteresis. Calculations are reported of the thermal deformation of the mirrors subjected to the effects of heat under various conditions, and also of the frequency characteristics of these mirrors. It is shown that such adaptive mirrors are effective in compensation for large-scale axisymmetric distortions of the wavefront in laser optics operating at powers up to 1 kW. The operational range of these mirrors is approximately ±20 μm in respect of the amplitude of the optical surface displacements and up to 1 kHz in respect of the frequency.

  14. A blind signal separation method for single-channel electromagnetic surveillance system

    NASA Astrophysics Data System (ADS)

    Pang, Lihui; Qi, Zhilong; Li, Shuai; Tang, Bin

    2015-10-01

    In this paper, a blind signal separation (BSS) methodology for simultaneously received multisystem frequency-overlapped signals in a single-channel (SC) electromagnetic surveillance system is proposed using fast independent component analysis (FastICA) in a dynamical embedding (DE) framework. Firstly, an appropriate DE matrix is constructed out of a series of delay vectors from the SC recording. The lag-time and the dimensional of embedding matrix setting principal are introduced in details. Next, multiple independent components (ICs) are calculated by decomposing the embedding matrix through FastICA algorithm, and ICs can be regarded as a convenient expansion basis of the original signals. Then, these ICs are projected back into the measurement space. After that, these projected ICs are classified and used for recovering the sources of interest based on their independent nature and their power density spectrum. Numerical simulation results obtained in evaluating the proposed methodology's performance confirmed the effectiveness of the proposed algorithm.

  15. Diacetin, a reliable cue and private communication channel in a specialized pollination system.

    PubMed

    Schäffler, Irmgard; Steiner, Kim E; Haid, Mark; van Berkel, Sander S; Gerlach, Günter; Johnson, Steven D; Wessjohann, Ludger; Dötterl, Stefan

    2015-08-06

    The interaction between floral oil secreting plants and oil-collecting bees is one of the most specialized of all pollination mutualisms. Yet, the specific stimuli used by the bees to locate their host flowers have remained elusive. This study identifies diacetin, a volatile acetylated glycerol, as a floral signal compound shared by unrelated oil plants from around the globe. Electrophysiological measurements of antennae and behavioural assays identified diacetin as the key volatile used by oil-collecting bees to locate their host flowers. Furthermore, electrophysiological measurements indicate that only oil-collecting bees are capable of detecting diacetin. The structural and obvious biosynthetic similarity between diacetin and associated floral oils make it a reliable cue for oil-collecting bees. It is easily perceived by oil bees, but can't be detected by other potential pollinators. Therefore, diacetin represents the first demonstrated private communication channel in a pollination system.

  16. Sensing pressure in the cardiovascular system: Gq-coupled mechanoreceptors and TRP channels.

    PubMed

    Sharif-Naeini, Reza; Folgering, Joost H A; Bichet, Delphine; Duprat, Fabrice; Delmas, Patrick; Patel, Amanda; Honoré, Eric

    2010-01-01

    Despite the central physiological importance of cardiovascular mechanotransduction, the molecular identities of the sensors and the signaling pathways have long remained elusive. Indeed, how pressure is transduced into cellular excitation has only recently started to emerge. In both arterial and cardiac myocytes, the diacylglycerol-sensitive canonical transient receptor potential (TRPC) subunits are proposed to underlie the stretch-activated depolarizing cation channels. An indirect mechanism of activation through a ligand-independent conformational switch of Gq-coupled receptors by mechanical stress is invoked. Such a mechanism involving the angiotensin type 1 receptor and TRPC6 is proposed to trigger the arterial myogenic response to intraluminal pressure. TRPC6 is also involved in load-induced cardiac hypertrophy. In this review, we will focus on the molecular basis of pressure sensing in the cardiovascular system and associated disease states.

  17. A wearable multi-channel fNIRS system for brain imaging in freely moving subjects.

    PubMed

    Piper, Sophie K; Krueger, Arne; Koch, Stefan P; Mehnert, Jan; Habermehl, Christina; Steinbrink, Jens; Obrig, Hellmuth; Schmitz, Christoph H

    2014-01-15

    Functional near infrared spectroscopy (fNIRS) is a versatile neuroimaging tool with an increasing acceptance in the neuroimaging community. While often lauded for its portability, most of the fNIRS setups employed in neuroscientific research still impose usage in a laboratory environment. We present a wearable, multi-channel fNIRS imaging system for functional brain imaging in unrestrained settings. The system operates without optical fiber bundles, using eight dual wavelength light emitting diodes and eight electro-optical sensors, which can be placed freely on the subject's head for direct illumination and detection. Its performance is tested on N=8 subjects in a motor execution paradigm performed under three different exercising conditions: (i) during outdoor bicycle riding, (ii) while pedaling on a stationary training bicycle, and (iii) sitting still on the training bicycle. Following left hand gripping, we observe a significant decrease in the deoxyhemoglobin concentration over the contralateral motor cortex in all three conditions. A significant task-related ΔHbO2 increase was seen for the non-pedaling condition. Although the gross movements involved in pedaling and steering a bike induced more motion artifacts than carrying out the same task while sitting still, we found no significant differences in the shape or amplitude of the HbR time courses for outdoor or indoor cycling and sitting still. We demonstrate the general feasibility of using wearable multi-channel NIRS during strenuous exercise in natural, unrestrained settings and discuss the origins and effects of data artifacts. We provide quantitative guidelines for taking condition-dependent signal quality into account to allow the comparison of data across various levels of physical exercise. To the best of our knowledge, this is the first demonstration of functional NIRS brain imaging during an outdoor activity in a real life situation in humans. PMID:23810973

  18. Bothriurus bonariensis scorpion venom activates voltage-dependent sodium channels in insect and mammalian nervous systems.

    PubMed

    Dos Santos, Douglas Silva; Carvalho, Evelise Leis; de Lima, Jeferson Camargo; Breda, Ricardo Vaz; Oliveira, Raquel Soares; de Freitas, Thiago Carrazoni; Salamoni, Simone Denise; Domingues, Michelle Flores; Piovesan, Angela Regina; Boldo, Juliano Tomazzoni; de Assis, Dênis Reis; da Costa, Jaderson Costa; Dal Belo, Cháriston André; Pinto, Paulo Marcos

    2016-10-25

    Animal venoms have been widely recognized as a major source of biologically active molecules. Bothriurus bonariensis, popularly known as black scorpion, is the arthropod responsible for the highest number of accidents involving scorpion sting in Southern Brazil. Here we reported the first attempt to investigate the neurobiology of B. bonariensis venom (BBV) in the insect and mammalian nervous system. BBV (32 μg/g) induced a slow neuromuscular blockade in the in vivo cockroach nerve-muscle preparations (70 ± 4%, n = 6, p < 0.001), provoking repetitive twitches and significantly decreasing the frequency of spontaneous leg action potentials (SNCAPs) from 82 ± 3 min(-1) to 36 ± 1.3 min(-1) (n = 6, p < 0.05), without affecting the amplitude. When tested in primary cultures of rat hippocampal cells, BBV induced a massive increase of Ca(2+) influx (250 ± 1% peak increase, n = 3, p < 0.0001). The disturbance of calcium homeostasis induced by BBV on the mammalian central nervous system was not accompanied by cellular death and was prevented by the co-treatment of the hippocampal cells with tetrodotoxin, a selective sodium channel blocker. The results suggest that the biological activity of BBV is mostly related to a modulation of sodium channels function. Our biological activity survey suggests that BBV may have a promising insecticidal and therapeutic potential. PMID:27544632

  19. A Wearable Multi-Channel fNIRS System for Brain Imaging in Freely Moving Subjects

    PubMed Central

    Piper, Sophie K.; Krueger, Arne; Koch, Stefan P.; Mehnert, Jan; Habermehl, Christina; Steinbrink, Jens; Obrig, Hellmuth; Schmitz, Christoph H.

    2013-01-01

    Functional near infrared spectroscopy (fNIRS) is a versatile neuroimaging tool with an increasing acceptance in the neuroimaging community. While often lauded for its portability, most of the fNIRS setups employed in neuroscientific research still impose usage in a laboratory environment. We present a wearable, multi-channel fNIRS imaging system for functional brain imaging in unrestrained settings. The system operates without optical fiber bundles, using eight dual wavelength light emitting diodes and eight electro-optical sensors, which can be placed freely on the subject's head for direct illumination and detection. Its performance is tested on N = 8 subjects in a motor execution paradigm performed under three different exercising conditions: (i) during outdoor bicycle riding, (ii) while pedaling on a stationary training bicycle, and (iii) sitting still on the training bicycle. Following left hand gripping, we observe a significant decrease in the deoxyhemoglobin concentration over the contralateral motor cortex in all three conditions. A significant task-related ΔHbO2 increase was seen for the non-pedaling condition. Although the gross movements involved in pedaling and steering a bike induced more motion artifacts than carrying out the same task while sitting still, we found no significant differences in the shape or amplitude of the HbR time courses for outdoor or indoor cycling and sitting still. We demonstrate the general feasibility of using wearable multi-channel NIRS during strenuous exercise in natural, unrestrained settings and discuss the origins and effects of data artifacts. We provide quantitative guidelines for taking condition-dependent signal quality into account to allow the comparison of data across various levels of physical exercise. To the best of our knowledge, this is the first demonstration of functional NIRS brain imaging during an outdoor activity in a real life situation in humans. PMID:23810973

  20. Design and realization of the control system for the three-channel birefringent filter

    NASA Astrophysics Data System (ADS)

    Zhu, Dan

    2008-07-01

    Space Solar Telescope is one of the large-scale scientific programs under development in China. In it, an important part is the filter, a birefringent filter with three-channels. It consists of 17 rotatable wave plates. In coordination with other mechanical and optical components, complicated and precise adjustments of their attitudes are necessary, which requests a high-accuracy control system to ensure their concertedness. The paper describes the design and realization of the control system. It mainly has a hardware plate and a software one. The former uses an industrial controller, a control card and step motors, while the latter uses the technique construction of the object oriented. That is modularization design with lengthwise dividing as per functions and breadthwise dividing as per element layers. Shift arithmetic for whole spectrum in programs is for intelligent spectral scanning. At the same time, the control information is roundly recorded in the data base of the system. Tests show that the system is characterized by high precision, good stabilization, high data safety and user-friendly interface, totally meeting the design requirements. Also discussed in this paper is some new conceivability to realize the handiness and miniaturization of the filter to fit the use in space flight in the future.

  1. 10-channel fiber array fabrication technique for parallel optical coherence tomography system

    NASA Astrophysics Data System (ADS)

    Arauz, Lina J.; Luo, Yuan; Castillo, Jose E.; Kostuk, Raymond K.; Barton, Jennifer

    2007-02-01

    Optical Coherence Tomography (OCT) shows great promise for low intrusive biomedical imaging applications. A parallel OCT system is a novel technique that replaces mechanical transverse scanning with electronic scanning. This will reduce the time required to acquire image data. In this system an array of small diameter fibers is required to obtain an image in the transverse direction. Each fiber in the array is configured in an interferometer and is used to image one pixel in the transverse direction. In this paper we describe a technique to package 15μm diameter fibers on a siliconsilica substrate to be used in a 2mm endoscopic probe tip. Single mode fibers are etched to reduce the cladding diameter from 125μm to 15μm. Etched fibers are placed into a 4mm by 150μm trench in a silicon-silica substrate and secured with UV glue. Active alignment was used to simplify the lay out of the fibers and minimize unwanted horizontal displacement of the fibers. A 10-channel fiber array was built, tested and later incorporated into a parallel optical coherence system. This paper describes the packaging, testing, and operation of the array in a parallel OCT system.

  2. An Inflatable and Wearable Wireless System for Making 32-Channel Electroencephalogram Measurements.

    PubMed

    Yu, Yi-Hsin; Lu, Shao-Wei; Chuang, Chun-Hsiang; King, Jung-Tai; Chang, Che-Lun; Chen, Shi-An; Chen, Sheng-Fu; Lin, Chin-Teng

    2016-07-01

    Potable electroencephalography (EEG) devices have become critical for important research. They have various applications, such as in brain-computer interfaces (BCI). Numerous recent investigations have focused on the development of dry sensors, but few concern the simultaneous attachment of high-density dry sensors to different regions of the scalp to receive qualified EEG signals from hairy sites. An inflatable and wearable wireless 32-channel EEG device was designed, prototyped, and experimentally validated for making EEG signal measurements; it incorporates spring-loaded dry sensors and a novel gasbag design to solve the problem of interference by hair. The cap is ventilated and incorporates a circuit board and battery with a high-tolerance wireless (Bluetooth) protocol and low power consumption characteristics. The proposed system provides a 500/250 Hz sampling rate, and 24 bit EEG data to meet the BCI system data requirement. Experimental results prove that the proposed EEG system is effective in measuring audio event-related potential, measuring visual event-related potential, and rapid serial visual presentation. Results of this work demonstrate that the proposed EEG cap system performs well in making EEG measurements and is feasible for practical applications. PMID:26780814

  3. Multi-channel high-speed CMOS image acquisition and pre-processing system

    NASA Astrophysics Data System (ADS)

    Sun, Chun-feng; Yuan, Feng; Ding, Zhen-liang

    2008-10-01

    A new multi-channel high-speed CMOS image acquisition and pre-processing system is designed to realize the image acquisition, data transmission, time sequential control and simple image processing by high-speed CMOS image sensor. The modular structure design, LVDS and ping-pong cache techniques used during the designed image data acquisition sub-system design ensure the real-time data acquisition and transmission. Furthermore, a new histogram equalization algorithm of adaptive threshold value based on the reassignment of redundant gray level is incorporated in the image preprocessing module of FPGA. The iterative method is used in the course of setting threshold value, and a redundant graylevel is redistributed rationally according to the proportional gray level interval. The over-enhancement of background is restrained and the feasibility of mergence of foreground details is reduced. The experimental certificates show that the system can be used to realize the image acquisition, transmission, memory and pre-processing to 590MPixels/s data size, and make for the design and realization of the subsequent system.

  4. Enhanced Handoff Scheme for Downlink-Uplink Asymmetric Channels in Cellular Systems

    PubMed Central

    2013-01-01

    In the latest cellular networks, data services like SNS and UCC can create asymmetric packet generation rates over the downlink and uplink channels. This asymmetry can lead to a downlink-uplink asymmetric channel condition being experienced by cell edge users. This paper proposes a handoff scheme to cope effectively with downlink-uplink asymmetric channels. The proposed handoff scheme exploits the uplink channel quality as well as the downlink channel quality to determine the appropriate timing and direction of handoff. We first introduce downlink and uplink channel models that consider the intercell interference, to verify the downlink-uplink channel asymmetry. Based on these results, we propose an enhanced handoff scheme that exploits both the uplink and downlink channel qualities to reduce the handoff-call dropping probability and the service interruption time. The simulation results show that the proposed handoff scheme reduces the handoff-call dropping probability about 30% and increases the satisfaction of the service interruption time requirement about 7% under high-offered load, compared to conventional mobile-assisted handoff. Especially, the proposed handoff scheme is more efficient when the uplink QoS requirement is much stricter than the downlink QoS requirement or uplink channel quality is worse than downlink channel quality. PMID:24501576

  5. The two-way time synchronization system via a satellite voice channel

    NASA Technical Reports Server (NTRS)

    Heng-Qiu, Zheng; Ren-Huan, Zhang; Yong-Hui, HU

    1994-01-01

    A newly developed two-way time synchronization system is described in this paper. The system uses one voice channel at a SCPC satellite digital communication earth station, whose bandwidth is only 45 kHz, thus saving satellite resources greatly. The system is composed of one master station and one or several, up to sixty-two, secondary stations. The master and secondary stations are equipped with the same equipment, including a set of timing equipment, a synthetic data terminal for time synchronizing, and a interface unit between the data terminal and the satellite earth station. The synthetic data terminal for time synchronization also has an IRIG-B code generator and a translator. The data terminal of master station is the key part of whole system. The system synchronization process is full automatic, which is controlled by the master station. Employing an autoscanning technique and conversational mode, the system accomplishes the following tasks: linking up liaison with each secondary station in turn, establishing a coarse time synchronization, calibrating date (years, months, days) and time of day (hours, minutes, seconds), precisely measuring the time difference between local station and the opposite station, exchanging measurement data, statistically processing the data, rejecting error terms, printing the data, calculating the clock difference and correcting the phase, thus realizing real-time synchronization from one point to multiple points. We also designed an adaptive phase circuit to eliminate the phase ambiguity of the PSK demodulator. The experiments have shown that the time synchronization accuracy is better than 2 mu S. The system has been put into regular operation.

  6. A dynamic multi-channel speech enhancement system for distributed microphones in a car environment

    NASA Astrophysics Data System (ADS)

    Matheja, Timo; Buck, Markus; Fingscheidt, Tim

    2013-12-01

    Supporting multiple active speakers in automotive hands-free or speech dialog applications is an interesting issue not least due to comfort reasons. Therefore, a multi-channel system for enhancement of speech signals captured by distributed distant microphones in a car environment is presented. Each of the potential speakers in the car has a dedicated directional microphone close to his position that captures the corresponding speech signal. The aim of the resulting overall system is twofold: On the one hand, a combination of an arbitrary pre-defined subset of speakers' signals can be performed, e.g., to create an output signal in a hands-free telephone conference call for a far-end communication partner. On the other hand, annoying cross-talk components from interfering sound sources occurring in multiple different mixed output signals are to be eliminated, motivated by the possibility of other hands-free applications being active in parallel. The system includes several signal processing stages. A dedicated signal processing block for interfering speaker cancellation attenuates the cross-talk components of undesired speech. Further signal enhancement comprises the reduction of residual cross-talk and background noise. Subsequently, a dynamic signal combination stage merges the processed single-microphone signals to obtain appropriate mixed signals at the system output that may be passed to applications such as telephony or a speech dialog system. Based on signal power ratios between the particular microphone signals, an appropriate speaker activity detection and therewith a robust control mechanism of the whole system is presented. The proposed system may be dynamically configured and has been evaluated for a car setup with four speakers sitting in the car cabin disturbed in various noise conditions.

  7. Reducing interferences in wireless communication systems by mobile agents with recurrent neural networks-based adaptive channel equalization

    NASA Astrophysics Data System (ADS)

    Beritelli, Francesco; Capizzi, Giacomo; Lo Sciuto, Grazia; Napoli, Christian; Tramontana, Emiliano; Woźniak, Marcin

    2015-09-01

    Solving channel equalization problem in communication systems is based on adaptive filtering algorithms. Today, Mobile Agents (MAs) with Recurrent Neural Networks (RNNs) can be also adopted for effective interference reduction in modern wireless communication systems (WCSs). In this paper MAs with RNNs are proposed as novel computing algorithms for reducing interferences in WCSs performing an adaptive channel equalization. The method to provide it is so called MAs-RNNs. We perform the implementation of this new paradigm for interferences reduction. Simulations results and evaluations demonstrates the effectiveness of this approach and as better transmission performance in wireless communication network can be achieved by using the MAs-RNNs based adaptive filtering algorithm.

  8. Investigation of the phase fluctuation effect on the BER performance of DPSK space downlink optical communication system on fluctuation channel

    NASA Astrophysics Data System (ADS)

    Li, Mi; Li, Bowen; Zhang, Xuping; Song, Yuejiang; Chang, Lingqian; Chen, Yuan

    2016-05-01

    Phase fluctuation effect is an important phenomenon on bit error rate (BER) performance on fluctuation channel in space downlink optical communication system. During research process, both intensity scintillation and phase fluctuation caused by atmospheric turbulence have been considered on fluctuation channel. Through the analysis of simulation results, the influence of phase fluctuation is not sensitive for wavelength and APD gain factor at high data rate. Besides, receiving diameter and divergence angle can be adjusted properly in order to obtain optimal BER performance. This work is helpful to the research of phase fluctuation and the design of practical system.

  9. In vivo 783-channel diffuse reflectance imaging system and its application

    NASA Astrophysics Data System (ADS)

    Yang, Joon-Mo; Han, Yong-Hui; Yoon, Gilwon; Ahn, Byung Soo; Lee, Byung-Cheon; Soh, Kwang-Sup

    2007-08-01

    A fiber-based reflectance imaging system was constructed to produce in vivo absorption spectroscopic images of biological tissues with diffuse light in the cw domain. The principal part of this system is the 783-channel fiber probe, composed of 253 illumination fibers and 530 detection fibers distributed in a 20×20 mm square region. During illumination with the 253 illumination fibers, diffuse reflected lights are collected by the 530 detection fibers and recorded simultaneously as an image with an electron multiplying CCD camera for fast data acquisition. After signal acquisition, a diffuse reflectance image was reconstructed by applying the spectral normalization method we devised. To test the applicability of the spectral normalization, we conducted two phantom experiments with chicken breast tissue and white Delrin resin by using animal blood as an optical inhomogeneity. In the Delrin phantom experiment, we present images produced by two methods, spectral normalization and reference signal normalization, along with a comparison of the two. To show the feasibility of our system for biomedical applications, we took images of a human vein in vivo with the spectral normalization method.

  10. New approaches in cellular radio systems using dynamic radio channel management

    NASA Astrophysics Data System (ADS)

    Yilmaz, Nusret; Ergul, F. R.

    2004-09-01

    New approaches are presented to facilitate dynamic radio bandwidth management for mobile communication systems. The aim is achieve an overall high level of QoS for both handoff calls and new calls. At the same time, the utilization of wireless network resources, i.e. the revenues earned by the operator. The simultaneous satisfaction of these two conflicting interests, under varying mobility and network traffic conditions, will be difficult. However, a balanced operation could be obtained by applying two novel approaches in system management. First, apriori information about possible handoffs, in the form of cell transition probabilities could be provided by the mobile, which is based on data collected by the mobile itself. This information is used to make handoff reservation requests in neighboring cells. Second, simultaneously controlling the radio resource reservation and new call admission to the system. This approach controls both the amount of reserved channels and the number of new calls admitted in a dynamic way. A theoretical analysis and a simulation have been used to study these approaches and it has been demonstrated that these approaches perform better then other reported approaches in the literature.

  11. On the capacity of MISO FSO systems over gamma-gamma and misalignment fading channels.

    PubMed

    Boluda-Ruiz, Rubén; García-Zambrana, Antonio; Castillo-Vázquez, Beatriz; Castillo-Vázquez, Carmen

    2015-08-24

    In this work, the ergodic capacity performance for multiple-input/single-output (MISO) free-space optical (FSO) communications system with equal gain combining (EGC) reception is analyzed over gamma-gamma and misalignment fading channels, which are modeled as statistically independent, but not necessarily identically distributed (i.n.i.d.). Novel and analytical closed-form ergodic capacity expression is obtained in terms of H-Fox function by using the well-known inequality between arithmetic and geometric mean of positive random variables (RV) in order to obtain an approximate closed-form expression of the distribution of the sum of M gamma-gamma with pointing errors variates. In addition, we present an asymptotic ergodic capacity expression at high signal-to-noise ratio (SNR) for the ergodic capacity of MISO FSO systems. It can be concluded that the use of MISO technique can significantly reduce the effect of the atmospheric turbulence as well as pointing errors and, hence, provide significant capacity gain over the direct path link (DL). The impact of pointing errors on the MISO FSO system is also analyzed, which only depends on the number of laser sources and pointing error parameters. Moreover, it can be also concluded that the ergodic capacity performance is dramatically reduced as a consequence of the severity of pointing error effects. Simulation results are further demonstrated to confirm the analytical results.

  12. Signal acquisition module design for multi-channel surface magnetic resonance sounding system.

    PubMed

    Lin, Tingting; Chen, Wuqiang; Du, Wenyuan; Zhao, Jing

    2015-11-01

    To obtain a precise 2D/3D image of fissure or karst water, multi-channel magnetic resonance sounding (MRS) systems using edge-to-edge or overlapping receiving coils are needed. Thus, acquiring a nano-volt signal for a small amount of the aquifer and suppressing the mutual coupling between adjacent coils are two important issues for the design of the signal acquisition module in the system. In the present study, we propose to use a passive low pass filter, consisted of a resistance (R) and capacitance (C), to inhibit the mutual coupling effects of the coils. Four low-noise operational amplifiers LT1028, OPA124, AD745, and OP27 were compared with respect to achieving the lowest system noise. As a result, 3 pieces of LT1028 were chosen and connected in parallel to serve as preamplifier, with a sensitivity of 1.4 nV/√Hz at 2 kHz. Experimental results are presented for 2D MRS groundwater investigations conducted in the suburb of Changchun, China. The inversion result is consistent with the result of drilling log, suggesting that the signal acquisition module is well developed. PMID:26628154

  13. Influence of the Coriolis force on the velocity structure of gravity currents in straight submarine channel systems

    NASA Astrophysics Data System (ADS)

    Cossu, R.; Wells, M. G.; WâHlin, A. K.

    2010-11-01

    Large-scale turbidity currents in submarine channels often show a significant asymmetry in the heights of their levee banks. In the Northern Hemisphere, there are many observations of the right-hand channel levee being noticeably higher than the left-hand levee, a phenomenon that is usually attributed to the effect of Coriolis forces upon turbidity currents. This article presents results from an analog model that documents the influence of Coriolis forces on the dynamics of gravity currents flowing in straight submarine channels. The observations of the transverse velocity structure, downstream velocity, and interface slope show good agreement with a theory that incorporates Ekman boundary layer dynamics. Coriolis forces will be important for most large-scale turbidity currents and need to be explicitly modeled when the Rossby number of these flows (defined as Ro = ∣U/Wf∣, where U is the mean downstream velocity, W is the channel width, and f is the Coriolis parameter defined as f = 2Ω sin(θ), with Ω being the Earth's rotation rate and θ being the latitude) is less than order 1. When Ro ≪ 1, the flow is substantially slower than a nonrotating flow with the same density contrast. The secondary flow field consists of frictionally induced Ekman transports across the channel in the benthic and interfacial boundary layers and a return flow in the interior. The cross-channel velocities are of the order of 10% of the along-channel velocities. The sediment transport associated with such transverse flow patterns should influence the evolution of submarine channel levee systems.

  14. Nonlinear channelizer.

    PubMed

    In, Visarath; Longhini, Patrick; Kho, Andy; Neff, Joseph D; Leung, Daniel; Liu, Norman; Meadows, Brian K; Gordon, Frank; Bulsara, Adi R; Palacios, Antonio

    2012-12-01

    The nonlinear channelizer is an integrated circuit made up of large parallel arrays of analog nonlinear oscillators, which, collectively, serve as a broad-spectrum analyzer with the ability to receive complex signals containing multiple frequencies and instantaneously lock-on or respond to a received signal in a few oscillation cycles. The concept is based on the generation of internal oscillations in coupled nonlinear systems that do not normally oscillate in the absence of coupling. In particular, the system consists of unidirectionally coupled bistable nonlinear elements, where the frequency and other dynamical characteristics of the emergent oscillations depend on the system's internal parameters and the received signal. These properties and characteristics are being employed to develop a system capable of locking onto any arbitrary input radio frequency signal. The system is efficient by eliminating the need for high-speed, high-accuracy analog-to-digital converters, and compact by making use of nonlinear coupled systems to act as a channelizer (frequency binning and channeling), a low noise amplifier, and a frequency down-converter in a single step which, in turn, will reduce the size, weight, power, and cost of the entire communication system. This paper covers the theory, numerical simulations, and some engineering details that validate the concept at the frequency band of 1-4 GHz.

  15. Performance of heterodyne differential phase-shift keying system over double Weibull free-space optical channel

    NASA Astrophysics Data System (ADS)

    Musa Hasan, Omar

    2015-06-01

    In this paper, the bit error rate (BER), outage probability, and outage rate analysis of the heterodyne differential phase-shift keying system over double Weibull-distributed free-space optical channel (FSO) are proposed. The channel statistics are modeled based on the scintillation theory and derived as the product of two independent Weibull random variables. Novel closed-form expressions for evaluating BER, outage probability, and outage rate are derived taking into account the effect of turbulence strength and inner-scale turbulent cell size. Numerical results are provided to evaluate the FSO system performance for weak to strong turbulence channel conditions and inner-scale turbulent cell size. The BER, outage probability, and outage rate performance are displayed for different values of turbulence strength conditions, inner-scale values and signal-to-noise ratios.

  16. Performance Analysis of MIMO-STBC Systems with Higher Coding Rate Using Adaptive Semiblind Channel Estimation Scheme

    PubMed Central

    Kumar, Ravi

    2014-01-01

    Semiblind channel estimation method provides the best trade-off in terms of bandwidth overhead, computational complexity and latency. The result after using multiple input multiple output (MIMO) systems shows higher data rate and longer transmit range without any requirement for additional bandwidth or transmit power. This paper presents the detailed analysis of diversity coding techniques using MIMO antenna systems. Different space time block codes (STBCs) schemes have been explored and analyzed with the proposed higher code rate. STBCs with higher code rates have been simulated for different modulation schemes using MATLAB environment and the simulated results have been compared in the semiblind environment which shows the improvement even in highly correlated antenna arrays and is found very close to the condition when channel state information (CSI) is known to the channel. PMID:24688379

  17. Aircraft Engine On-Line Diagnostics Through Dual-Channel Sensor Measurements: Development of an Enhanced System

    NASA Technical Reports Server (NTRS)

    Kobayashi, Takahisa; Simon, Donald L.

    2008-01-01

    In this paper, an enhanced on-line diagnostic system which utilizes dual-channel sensor measurements is developed for the aircraft engine application. The enhanced system is composed of a nonlinear on-board engine model (NOBEM), the hybrid Kalman filter (HKF) algorithm, and fault detection and isolation (FDI) logic. The NOBEM provides the analytical third channel against which the dual-channel measurements are compared. The NOBEM is further utilized as part of the HKF algorithm which estimates measured engine parameters. Engine parameters obtained from the dual-channel measurements, the NOBEM, and the HKF are compared against each other. When the discrepancy among the signals exceeds a tolerance level, the FDI logic determines the cause of discrepancy. Through this approach, the enhanced system achieves the following objectives: 1) anomaly detection, 2) component fault detection, and 3) sensor fault detection and isolation. The performance of the enhanced system is evaluated in a simulation environment using faults in sensors and components, and it is compared to an existing baseline system.

  18. Systems dynamic modeling of a guard cell Cl- channel mutant uncovers an emergent homeostatic network regulating stomatal transpiration.

    PubMed

    Wang, Yizhou; Papanatsiou, Maria; Eisenach, Cornelia; Karnik, Rucha; Williams, Mary; Hills, Adrian; Lew, Virgilio L; Blatt, Michael R

    2012-12-01

    Stomata account for much of the 70% of global water usage associated with agriculture and have a profound impact on the water and carbon cycles of the world. Stomata have long been modeled mathematically, but until now, no systems analysis of a plant cell has yielded detail sufficient to guide phenotypic and mutational analysis. Here, we demonstrate the predictive power of a systems dynamic model in Arabidopsis (Arabidopsis thaliana) to explain the paradoxical suppression of channels that facilitate K(+) uptake, slowing stomatal opening, by mutation of the SLAC1 anion channel, which mediates solute loss for closure. The model showed how anion accumulation in the mutant suppressed the H(+) load on the cytosol and promoted Ca(2+) influx to elevate cytosolic pH (pH(i)) and free cytosolic Ca(2+) concentration ([Ca(2+)](i)), in turn regulating the K(+) channels. We have confirmed these predictions, measuring pH(i) and [Ca(2+)](i) in vivo, and report that experimental manipulation of pH(i) and [Ca(2+)](i) is sufficient to recover K(+) channel activities and accelerate stomatal opening in the slac1 mutant. Thus, we uncover a previously unrecognized signaling network that ameliorates the effects of the slac1 mutant on transpiration by regulating the K(+) channels. Additionally, these findings underscore the importance of H(+)-coupled anion transport for pH(i) homeostasis.

  19. The Nucleolar Channel System of Human Endometrium Is Related to Endoplasmic Reticulum and R-Rings

    PubMed Central

    Kittur, Nupur; Zapantis, Gregory; Aubuchon, Mira; Santoro, Nanette; Bazett-Jones, David P.

    2007-01-01

    The nucleolar channel system (NCS) is a well-established ultrastructural hallmark of the postovulation endometrium. Its transient presence has been associated with human fertility. Nevertheless, the biogenesis, composition, and function of these intranuclear membrane cisternae are unknown. Membrane systems with a striking ultrastructural resemblance to the NCS, termed R-rings, are induced in nuclei of tissue culture cells by overexpression of the central repeat domain of the nucleolar protein Nopp140. Here we provide a first molecular characterization of the NCS and compare the biogenesis of these two enigmatic organelles. Like the R-rings, the NCS consists of endoplasmic reticulum harboring the marker glucose-6-phosphatase. R-ring formation initiates at the nuclear envelope, apparently by a calcium-mediated Nopp140-membrane interaction, as supported by the calcium-binding ability of Nopp140, the inhibition of R-ring formation by calcium chelators, and the concentration of Nopp140 and complexed calcium in R-rings. Although biogenesis of the NCS may initiate similarly, the reduced presence of complexed calcium and Nopp140 suggests the involvement of additional factors. PMID:17429075

  20. Channel-wing System for Thrust Deflection and Force/Moment Generation

    NASA Technical Reports Server (NTRS)

    Englar, Robert J. (Inventor); Bushnell, Dennis M. (Inventor)

    2006-01-01

    An aircraft comprising a Channel Wing having blown c h - ne1 circulation control wings (CCW) for various functions. The blown channel CCW includes a channel that has a rounded or near-round trailing edge. The channel further has a trailing-edge slot that is adjacent to the rounded trailing edge of the channel. The trailing-edge slot has an inlet connected to a source of pressurized air and is capable of tangentially discharging pressurized air over the rounded trailing edge. The aircraft further has a propeller that is located in the channel and ahead of the rounded trailing edge of the channel. The propeller provides a propeller thrust exhaust stream across the channel wing to propel the aircraft through the air and to provide high lift. The pressurized air being discharged over the rounded trailing edge provides a high lift that is obtained independent of an aircraft angle of attack, thus preventing the asymmetry. separated flow, and stall experienced by the CC wing at the high angle of attack it required for high lift generation. The aircraft can further include blown outboard circulation control wings (CCW) that are synergistically connected to the blown channel CCWs. The blown outboard CCWs provide additional high lift, control thrust/drag interchange, and can provide all three aerodynamic moments when differential blowing is applied front-to-rear or left-to-right. Both the blown channel CCW and the outboard CCW also have leading-edge blowing slots to prevent flow separation or to provide aerodynamic moments for control.

  1. A novel design of dual-channel optical system of star-tracker based on non-blind area PAL system

    NASA Astrophysics Data System (ADS)

    Luo, Yujie; Bai, Jian

    2016-07-01

    Star-tracker plays an important role in satellite navigation. Considering the satellites on near-Earth orbit, the system usually has two optical systems: one for observing the profile of Earth and the other for capturing the positions of stars. In this paper, we demonstrate a novel kind of dual-channel optical observation system of star-tracker with non-blind area PAL imaging system based on dichroic filter, which can combine both different observation channels into an integrated structure and realize the feature of miniaturization. According to the practical usage of star-tracker and the features of dichroic filter, we set the ultraviolet band as the PAL channel to observe the Earth with the FOV ranging from 40°-60°, and set the visible band as the front imaging channel to capture the stars far away from this system with the FOV ranging from 0°-20°. Consequently, the rays of both channels are converged on the same image plane, improving the efficiency of pixels of detector and reducing the weight and size of whole star-tracker system.

  2. Interaction of salt tectonics, slumping and channeling: Mid-Pliocene reservoir system, Pompano Field, Gulf of Mexico

    SciTech Connect

    Blankenship, C.L.; Stauber, D.A.; Epps, D.S.

    1996-12-31

    Newly reprocessed 3-D seismic, converted to Acoustic Impedance, shows the detailed stratigraphy of the mid-Pliocene, upper slope reservoir system of the Pompano Field. This improved data allows us to view the internal slumping and channeling in an interval which was previously poorly imaged. Pompano is located in the Gulf of Mexico at the boundary of Mississippi Canyon and Viosca Knoll.

  3. Interaction of salt tectonics, slumping and channeling: Mid-Pliocene reservoir system, Pompano Field, Gulf of Mexico

    SciTech Connect

    Blankenship, C.L.; Stauber, D.A.; Epps, D.S. )

    1996-01-01

    Newly reprocessed 3-D seismic, converted to Acoustic Impedance, shows the detailed stratigraphy of the mid-Pliocene, upper slope reservoir system of the Pompano Field. This improved data allows us to view the internal slumping and channeling in an interval which was previously poorly imaged. Pompano is located in the Gulf of Mexico at the boundary of Mississippi Canyon and Viosca Knoll.

  4. Co-evolution of Riparian Vegetation and Channel Dynamics in an Aggrading Braided River System, Mount Pinatubo, Philippines

    NASA Astrophysics Data System (ADS)

    Gran, K. B.; Michal, T.

    2014-12-01

    Increased bank stability by riparian vegetation in braided rivers can decrease bed reworking rates and focus the flow. The magnitude of influence and resulting channel morphology are functions of vegetation strength vs. channel dynamics, a concept encapsulated in a dimensionless ratio between timescales for vegetation growth and channel reworking known as T*. We investigate this relationship in an aggrading braided river at Mount Pinatubo, Philippines, and compare results to numerical and physical models. Gradual reductions in post-eruption sediment loads have reduced bed reworking rates, allowing vegetation to persist year-round and impact channel dynamics on the Pasig-Potrero and Sacobia Rivers. From 2009-2011, we collected data detailing vegetation extent, type, density, and root strength. Incorporating these data into RipRoot and BSTEM models shows cohesion due to roots increased from zero in unvegetated conditions to >10.2 kPa in densely-growing grasses. Field-based parameters were incorporated into a cellular model comparing vegetation growth and sediment mobility effects on braided channel dynamics. The model shows that both low sediment mobility and high vegetation strength lead to less active systems, reflecting trends observed in the field. An estimated T* between 0.8 - 2.3 for the Pasig-Potrero River suggests channels were mobile enough to maintain the braidplain width clear of vegetation and even experience slight gains in area through annual removal of existing vegetation. However, persistent vegetation focused flow and thus aggradation over the unvegetated fraction of braidplain, leading to an aggradational imbalance and transition to a more avulsive state. While physical models predict continued narrowing of the active braidplain as T* declines, the future trajectory of channel-vegetation interactions at Pinatubo as sedimentation rates decline appears more complicated due to strong seasonal variability in precipitation and sediment loads. By 2011

  5. The role of ATP-sensitive potassium channels in cellular function and protection in the cardiovascular system.

    PubMed

    Tinker, Andrew; Aziz, Qadeer; Thomas, Alison

    2014-01-01

    ATP-sensitive potassium channels (K(ATP)) are widely distributed and present in a number of tissues including muscle, pancreatic beta cells and the brain. Their activity is regulated by adenine nucleotides, characteristically being activated by falling ATP and rising ADP levels. Thus, they link cellular metabolism with membrane excitability. Recent studies using genetically modified mice and genomic studies in patients have implicated K(ATP) channels in a number of physiological and pathological processes. In this review, we focus on their role in cellular function and protection particularly in the cardiovascular system.

  6. Estimation of Symmetric Channels for Discrete Cosine Transform Type-I Multicarrier Systems: A Compressed Sensing Approach

    PubMed Central

    Domínguez-Jiménez, María Elena; Luengo, David; Sansigre-Vidal, Gabriela

    2015-01-01

    The problem of channel estimation for multicarrier communications is addressed. We focus on systems employing the Discrete Cosine Transform Type-I (DCT1) even at both the transmitter and the receiver, presenting an algorithm which achieves an accurate estimation of symmetric channel filters using only a small number of training symbols. The solution is obtained by using either matrix inversion or compressed sensing algorithms. We provide the theoretical results which guarantee the validity of the proposed technique for the DCT1. Numerical simulations illustrate the good behaviour of the proposed algorithm. PMID:26568981

  7. Microfluidic channel fabrication method

    DOEpatents

    Arnold, Don W.; Schoeniger, Joseph S.; Cardinale, Gregory F.

    2001-01-01

    A new channel structure for microfluidic systems and process for fabricating this structure. In contrast to the conventional practice of fabricating fluid channels as trenches or grooves in a substrate, fluid channels are fabricated as thin walled raised structures on a substrate. Microfluidic devices produced in accordance with the invention are a hybrid assembly generally consisting of three layers: 1) a substrate that can or cannot be an electrical insulator; 2) a middle layer, that is an electrically conducting material and preferably silicon, forms the channel walls whose height defines the channel height, joined to and extending from the substrate; and 3) a top layer, joined to the top of the channels, that forms a cover for the channels. The channels can be defined by photolithographic techniques and are produced by etching away the material around the channel walls.

  8. Vertical profiles of atmospheric fluorescent aerosols observed by a mutil-channel lidar spectrometer system

    NASA Astrophysics Data System (ADS)

    Huang, Z.; Huang, J.; Zhou, T.; Sugimoto, N.; Bi, J.

    2015-12-01

    Zhongwei Huang1*, Jianping Huang1, Tian Zhou1, Nobuo Sugimoto2, Jianrong Bi1 and Jinsen Shi11Key Laboratory for Semi-Arid Climate Change of the Ministry of Education, College of Atmospheric Sciences, Lanzhou University, Lanzhou, China. 2Atmospheric Environment Division, National Institutes for Environmental Studies, Tsukuba, Japan Email: huangzhongwei@lzu.edu.cn Abstract Atmospheric aerosols have a significant impact on regional and globe climate. The challenge in quantifying aerosol direct radiative forcing and aerosol-cloud interactions arises from large spatial and temporal heterogeneity of aerosol concentrations, compositions, sizes, shape and optical properties (IPCC, 2007). Lidar offers some remarkable advantages for determining the vertical structure of atmospheric aerosols and their related optical properties. To investigate the characterization of atmospheric aerosols (especially bioaerosols) with high spatial and temporal resolution, we developed a Raman/fluorescence/polarization lidar system employed a multi-channel spectrometer, with capabilities of providing measurements of Raman scattering and laser-induced fluorescence excitation at 355 nm from atmospheric aerosols. Meanwhile, the lidar system operated polarization measurements both at 355nm and 532nm wavelengths, aiming to obtain more information of aerosols. It employs a high power pulsed laser and a received telescope with 350mm diameter. The receiver could simultaneously detect a wide fluorescent spectrum about 178 nm with spectral resolution 5.7 nm, mainly including an F/3.7 Crossed Czerny-Turner spectrograph, a grating (1200 gr/mm) and a PMT array with 32 photocathode elements. Vertical structure of fluorescent aerosols in the atmosphere was observed by the developed lidar system at four sites across northwest China, during 2014 spring field observation that conducted by Lanzhou University. It has been proved that the developed lidar could detect the fluorescent aerosols with high temporal and

  9. Seismic stratigraphy of the Qiongdongnan deep sea channel system, northwest South China Sea

    NASA Astrophysics Data System (ADS)

    Yuan, Shengqiang; Lü, Fuliang; Wu, Shiguo; Yao, Genshun; Ma, Yubo; Fu, Yanhui

    2009-05-01

    Based on more than 4000 km 2D seismic data and seismic stratigraphic analysis, we discussed the extent and formation mechanism of the Qiongdongnan deep sea channel. The Qiongdongnan deep sea channel is a large incised channel which extends from the east boundary of the Yinggehai Basin, through the whole Qiongdongnan and the Xisha trough, and terminates in the western part of the northwest subbasin of South China Sea. It is more than 570 km long and 4-8 km wide. The chaotic (or continuous) middle (or high) amplitude, middle (or high) continuity seismic facies of the channel reflect the different lithological distribution of the channel. The channel formed as a complex result of global sea level drop during early Pliocene, large scale of sediment supply to the Yinggehai Basin, inversion event of the Red River strike-slip fault, and tilted direction of the Qiongdongnan Basin. The large scale of sediment supply from Red River caused the shelf break of the Yinggehai Basin to move torwards the S and SE direction and developed large scale of prograding wedge from the Miocene, and the inversion of the Red River strike-slip fault induced the sediment slump which formed the Qiongdongnan deep sea channel.

  10. Before-after environmental impact assessment of an artificial channel opening on a south-western Atlantic choked lagoon system.

    PubMed

    Prestrelo, L; Monteiro-Neto, C

    2016-07-01

    This study aimed to evaluate the human induced impact of a channel opening in a choked lagoon and attempted to establish the cause-effect links for the observed changes. The same lagoon system was sampled before and after the channel opening event, and the differences in fish and crustacean assemblages and environmental variables between these periods analysed. The opening of the artificial channel resulted in salinity increases, leading to a shift in species composition, favouring marine species and reducing abundance and diversity of previously dominant freshwater species. Furthermore, saltwater entrance into the choked lagoon caused an unexpected decrease in species richness and biomass, plus deterioration of ecosystem processes, reducing fishing capacity. The effects of salinity on the ecosystem vary depending on the ecosystem's composition and capacity to overcome salinity changes, thus specific monitoring projects are important strategies for developing coastal lagoon conservation management. PMID:27250914

  11. Characteristics and roles of the volume-sensitive outwardly rectifying (VSOR) anion channel in the central nervous system.

    PubMed

    Akita, T; Okada, Y

    2014-09-01

    Cell volume regulation (CVR) is essential for all types of cells in the central nervous system (CNS) to counteract cell volume changes that may be associated with neuronal activities or diseases and with osmosensing in the hypothalamus, to facilitate morphological changes during cell proliferation, differentiation and migration, and to execute apoptosis of cells. The regulation is attained by regulating the net influx or efflux of solutes and water across the plasma membrane. The volume-sensitive outwardly rectifying (VSOR) anion channel plays a major role in providing a pathway for anion flux during the regulation. The VSOR anion channel is permeable not only to Cl(-) ions but also to amino acids like glutamate and taurine. This property confers a means of intercellular communications through the opening of the channel in the CNS. Thus exploring the roles of VSOR anion channels is crucial to understand the basic principles of cellular functions in the CNS. Here we review biophysical and pharmacological characteristics of the VSOR anion channel in the CNS, discuss its activation mechanisms and roles in the CNS reported so far, and give some perspectives on the next issues to be examined in the near future.

  12. Characteristics and roles of the volume-sensitive outwardly rectifying (VSOR) anion channel in the central nervous system.

    PubMed

    Akita, T; Okada, Y

    2014-09-01

    Cell volume regulation (CVR) is essential for all types of cells in the central nervous system (CNS) to counteract cell volume changes that may be associated with neuronal activities or diseases and with osmosensing in the hypothalamus, to facilitate morphological changes during cell proliferation, differentiation and migration, and to execute apoptosis of cells. The regulation is attained by regulating the net influx or efflux of solutes and water across the plasma membrane. The volume-sensitive outwardly rectifying (VSOR) anion channel plays a major role in providing a pathway for anion flux during the regulation. The VSOR anion channel is permeable not only to Cl(-) ions but also to amino acids like glutamate and taurine. This property confers a means of intercellular communications through the opening of the channel in the CNS. Thus exploring the roles of VSOR anion channels is crucial to understand the basic principles of cellular functions in the CNS. Here we review biophysical and pharmacological characteristics of the VSOR anion channel in the CNS, discuss its activation mechanisms and roles in the CNS reported so far, and give some perspectives on the next issues to be examined in the near future. PMID:24937753

  13. Channel based generating function approach to the stochastic Hodgkin-Huxley neuronal system

    NASA Astrophysics Data System (ADS)

    Ling, Anqi; Huang, Yandong; Shuai, Jianwei; Lan, Yueheng

    2016-03-01

    Internal and external fluctuations, such as channel noise and synaptic noise, contribute to the generation of spontaneous action potentials in neurons. Many different Langevin approaches have been proposed to speed up the computation but with waning accuracy especially at small channel numbers. We apply a generating function approach to the master equation for the ion channel dynamics and further propose two accelerating algorithms, with an accuracy close to the Gillespie algorithm but with much higher efficiency, opening the door for expedited simulation of noisy action potential propagating along axons or other types of noisy signal transduction.

  14. Channel based generating function approach to the stochastic Hodgkin-Huxley neuronal system

    PubMed Central

    Ling, Anqi; Huang, Yandong; Shuai, Jianwei; Lan, Yueheng

    2016-01-01

    Internal and external fluctuations, such as channel noise and synaptic noise, contribute to the generation of spontaneous action potentials in neurons. Many different Langevin approaches have been proposed to speed up the computation but with waning accuracy especially at small channel numbers. We apply a generating function approach to the master equation for the ion channel dynamics and further propose two accelerating algorithms, with an accuracy close to the Gillespie algorithm but with much higher efficiency, opening the door for expedited simulation of noisy action potential propagating along axons or other types of noisy signal transduction. PMID:26940002

  15. Ontophyletics of the nervous system: eyeless mutants illustrate how ontogenetic buffer mechanisms channel evolution.

    PubMed Central

    Katz, M J; Lasek, R J; Kaiserman-Abramof, I R

    1981-01-01

    Genetics and molecular biology have shown the mechanisms that allow the genome to provide both the continuity and the variation from generation to generation within a phylogeny. Embryology and developmental biology show the mechanisms that turn the genome into an organism. Mutations, the basis for evolutionary change, cannot in themselves ensure concordance between their products and the products of unchanged genes. Thus, mutations will not necessarily produce a viable organism. On the other hand, ontogenetic buffer mechanisms normally maintain concordance in the developing organism. In addition, ontogenetic buffer mechanisms can integrate discordant mutations into viable organisms that can then be perpetuated during evolution. The evolutionary role of one ontogenetic buffer mechanism, compensatory innervation, is well illustrated in the anopthalmic mutant mouse. In the anopthalmic mouse, a single gene mutation removes afferent axons of the dorsal lateral geniculate nucleus, and compensatory innervation by another population of axons ensures that the dorsal lateral geniculate remains integrated into the central nervous system. Within each organism's ontogeny is a hierarchy of sources of compensatory innervation, and this hierarchy will determine how any particular deafferentating mutation will be buffered. In this way, an ontogeny can channel the phylogeny of which it is a member. PMID:6941255

  16. Copper and zinc effects on hematologic system and immune responses in channel catfish, Ictalurus punctatus

    SciTech Connect

    Zaki, M.S.A.; Thune, R.L.; Means, J.C.

    1995-12-31

    Channel catfish were exposed to sublethal doses of copper, zinc or copper+ zinc in a computer-controlled, continuous flow dilutor system for 14 or 28 days. Tissue levels of metals were assessed in gill, liver and muscle by ICP/MS following digestion. Significant changes were observed in a number of hematological indices including total red, white and differential white blood cell counts after 28 d with all treatments, while effects were only observed with copper at 14 days. The production of antibodies to the infectious bacterium Edwardsiella ictaluri measured by ELISA were significantly depressed in copper exposed fish while it was increased significantly in both zinc and copper+zinc exposed fish. Copper exposure enhanced the susceptibility of the catfish to an infectious challenge of E ictaluri, while zinc decreased susceptibility. The copper + zinc fish showed increased susceptibility relative to controls, however, the presence of zinc mitigated the effects of copper in these fish. Responses in laboratory exposures were compared to field exposures measured in fish at several aquaculture facilities.

  17. Fetal cardiac activity analysis during twin pregnancy using a multi-channel SQUID system

    NASA Astrophysics Data System (ADS)

    Costa Monteiro, E.; Schleussner, E.; Kausch, S.; Grimm, B.; Schneider, A.; Hall Barbosa, C.; Haueisen, J.

    2001-05-01

    The use of SQUID magnetometers for non-invasive in utero assessment of cardiac electrical disturbances has already been shown to be a valuable clinical tool. In this way, its applicability also for the complicated case of twin pregnancy, in which the proximity of the cardiac magnetic source of each fetus can hamper the individual analysis of cardiac electrical activity, is of clinical interest. In this paper, we present fetal magnetocardiography performed on a mother pregnant of twins with 26 weeks gestational age, measured inside a magnetically shielded room, by using two identical 31-channel low- Tc SQUID magnetometer systems. Each sensor array has been positioned over one of the fetuses, according to its heart position previously assessed with the aid of ultrasound measurements. The raw data is initially averaged in time and, afterwards, analyzed by means of time plots and isofield maps. The time recordings allow the study of the morphology of each fetus’ cardiac signal and the cardiac time intervals. The resultant equivalent dipole obtained from the isofield maps indicates the position and orientation of each fetus heart. The results agree with the ultrasound analysis performed immediately before the measurements and used to obtain the approximate location of the fetuses’ hearts. Since a distinct analysis of the cardiac electrical activity of each fetus could be achieved, the results indicate the potential of the fetal magnetocardiography in the individual antenatal diagnosis of each one of the fetuses of a twin pregnancy.

  18. SINCGARS (Single-Channel Ground/Airborne Radio System) operator performance decay

    NASA Astrophysics Data System (ADS)

    Palmer, Richard L.; Buckalew, Louis W.

    1988-11-01

    The Single-Channel Ground/Airborne Radio System (SINCGARS) is scheduled to replace the Army's VRC-12 and PRC-77 radios. However, SINCGARS is more complex to operate and requires more training. This study examined the decay of operational skills and knowledge in two groups of recently trained operators who went without exposure to SINCGARS for several weeks. Performance levels were measured with the SINCGARS Learning-Retention Test (SLRT), a simulated hands-on performance test emphasizing skills and operational knowledge retention. The results provided tentative indications that operators may lose about 10 percent of their prior performance levels within the first few weeks. This figure is expected to vary considerably, depending on the type of soldier, the length of the nonexposure period, and other conditions. It was also found that performance level was correlated with soldiers' Armed Services Vocational Aptitude Battery (ASVAB) General Technical (GT) scores. Correlations between GT and SLRT scores obtained at two different times were .43 and .50, respectively. However, no relation was observed between performance decay and GT. Further evaluation of operator performance decay needs to be done to determine the effect of longer periods of nonexposure (e.g., 60 and 90 days).

  19. Communication and Control System for a 15-Channel Hermetic Retinal Prosthesis

    PubMed Central

    Kelly, Shawn K.; Shire, Douglas B.; Chen, Jinghua; Doyle, Patrick; Gingerich, Marcus D.; Cogan, Stuart F.; Drohan, William A.; Theogarajan, Luke S.; Wyatt, John L.; Rizzo, Joseph F.

    2011-01-01

    A small, hermetic, wirelessy-controlled retinal prosthesis has been developed for pre-clinical studies in Yucatan minipigs. The device was attached conformally to the outside of the eye in the socket and received both power and data wirelessly from external sources. Based on the received image data, the prosthesis drove a subretinal thin-film polyimide array of sputtered iridium oxide stimulating electrodes. The implanted device included a hermetic titanium case containing a 15-channel stimulator and receiver chip and discrete circuit components. Feedthroughs in the hermetic case connected the chip to secondary power- and data-receiving coils, which coupled to corresponding external power and data coils driven by power amplifiers. Power was delivered by a 125 KHz carrier, and data were delivered by amplitude shift keying of a 15.5 MHz carrier at 100 Kbps. Stimulation pulse strength, duration and frequency were programmed wirelessly from an external computer system. The final assembly was tested in vitro in physiological saline and in vivo in two minipigs for up to five and a half months by measuring stimulus artifacts generated by the implant’s current drivers. PMID:21927618

  20. Evaluation of a limestone channel and wetland system for treating acid mine drainage

    SciTech Connect

    Brenner, F.J.; Pruent, P.

    1999-07-01

    The Carpentertown Coal and Coke Company operated two drift mines on the site for 17 years closing in December 1987, but the company continued to operate a cleaning plant and coal refuse disposal site until the company declared bankruptcy in June 1989. In summer of 1993, eight acid seeps developed from the 2 ha coal refuse site with a combined flow of 36 1/min with iron and manganese loading rates of 419 and 576 gm/day. In 1995, a 212 m (700 ft) open limestone channel (OLC) and a 344 m{sup 2} (1,142 ft{sup 2}) and a 2,110 m{sup 2}(43,750 ft{sup 2}) aerobic wetland was constructed as a passive treatment system. over the 34-month monitoring period, the acid loading to the receiving stream was reduced by 88% with a corresponding increase of 111% in alkalinity. The iron and manganese loading to the receiving stream was reduced by 91% and 57%, respectively.

  1. Channel-tunnels: outer membrane components of type I secretion systems and multidrug efflux pumps of Gram-negative bacteria.

    PubMed

    Andersen, C

    2003-01-01

    For translocation across the cell envelope of Gram-negative bacteria, substances have to overcome two permeability barriers, the inner and outer membrane. Channel-tunnels are outer membrane proteins, which are central to two distinct export systems: the type I secretion system exporting proteins such as toxins or proteases, and efflux pumps discharging antibiotics, dyes, or heavy metals and thus mediating drug resistance. Protein secretion is driven by an inner membrane ATP-binding cassette (ABC) transporter while drug efflux occurs via an inner membrane proton antiporter. Both inner membrane transporters are associated with a periplasmic accessory protein that recruits an outer membrane channel-tunnel to form a functional export complex. Prototypes of these export systems are the hemolysin secretion system and the AcrAB/TolC drug efflux pump of Escherichia coli, which both employ TolC as an outer membrane component. Its remarkable conduit-like structure, protruding 100 A into the periplasmic space, reveals how both systems are capable of transporting substrates across both membranes directly from the cytosol into the external environment. Proteins of the channel-tunnel family are widespread within Gram-negative bacteria. Their involvement in drug resistance and in secretion of pathogenic factors makes them an interesting system for further studies. Understanding the mechanism of the different export apparatus could help to develop new drugs, which block the efflux pumps or the secretion system.

  2. Exploring the Membrane Potential of Simple Dual-Membrane Systems as Models for Gap-Junction Channels.

    PubMed

    Escalona, Yerko; Garate, Jose A; Araya-Secchi, Raul; Huynh, Tien; Zhou, Ruhong; Perez-Acle, Tomas

    2016-06-21

    The conductance of ion channels can be modulated by a transmembrane potential difference, due to alterations on ion-mobility and also by changes in the pore structure. Despite the vast knowledge regarding the influence of voltage on transport properties of ion channels, little attention has been paid to describe, with atomic detail, the modulation of ionic transport in gap-junction channels (GJCs). Hence, molecular dynamics simulations were performed to explore the conductance of simple dual-membrane systems that account for the very basic features of GJCs. In doing so, we studied the influence of different charge distributions in the channel surface on these idealized systems under external electric fields, paying attention to the behavior of the electrostatic potential, ion density, ion currents, and equilibrium properties. Our results demonstrate that the incorporation of a charge distribution akin GJCs decreased anionic currents, favoring the transport of cationic species. Moreover, a thermodynamic characterization of ionic transport in these systems demonstrate the existence of a kinetic barrier that hinders anionic currents, reinforcing the role played by the internal arrangement of charges in GJCs. Overall, our results provide insights at the atomic scale on the effects of charge distributions over ionic transport, constituting a step forward into a better understanding of GJCs. PMID:27332126

  3. A New High Channel-Count, High Scan-Rate, Data Acquisition System for the NASA Langley Transonic Dynamics Tunnel

    NASA Technical Reports Server (NTRS)

    Ivanco, Thomas G.; Sekula, Martin K.; Piatak, David J.; Simmons, Scott A.; Babel, Walter C.; Collins, Jesse G.; Ramey, James M.; Heald, Dean M.

    2016-01-01

    A data acquisition system upgrade project, known as AB-DAS, is underway at the NASA Langley Transonic Dynamics Tunnel. AB-DAS will soon serve as the primary data system and will substantially increase the scan-rate capabilities and analog channel count while maintaining other unique aeroelastic and dynamic test capabilities required of the facility. AB-DAS is configurable, adaptable, and enables buffet and aeroacoustic tests by synchronously scanning all analog channels and recording the high scan-rate time history values for each data quantity. AB-DAS is currently available for use as a stand-alone data system with limited capabilities while development continues. This paper describes AB-DAS, the design methodology, and the current features and capabilities. It also outlines the future work and projected capabilities following completion of the data system upgrade project.

  4. The effects of receiver tracking phase error on the performance of the concatenated Reed-Solomon/Viterbi channel coding system

    NASA Technical Reports Server (NTRS)

    Liu, K. Y.

    1981-01-01

    Analytical and experimental results are presented of the effects of receiver tracking phase error, caused by weak signal conditions on either the uplink or the downlink or both, on the performance of the concatenated Reed-Solomon (RS) Viterbi channel coding system. The test results were obtained under an emulated S band uplink and X band downlink, two way space communication channel in the telecommunication development laboratory of JPL with data rates ranging from 4 kHz to 20 kHz. It is shown that, with ideal interleaving, the concatenated RS/Viterbi coding system is capable of yielding large coding gains at very low bit error probabilities over the Viterbi decoded convolutional only coding system. Results on the effects of receiver tracking phase errors on the performance of the concatenated coding system with antenna array combining are included.

  5. Phase locking of a seven-channel continuous wave fibre laser system by a stochastic parallel gradient algorithm

    SciTech Connect

    Volkov, M V; Garanin, S G; Dolgopolov, Yu V; Kopalkin, A V; Kulikov, S M; Sinyavin, D N; Starikov, F A; Sukharev, S A; Tyutin, S V; Khokhlov, S V; Chaparin, D A

    2014-11-30

    A seven-channel fibre laser system operated by the master oscillator – multichannel power amplifier scheme is the phase locked using a stochastic parallel gradient algorithm. The phase modulators on lithium niobate crystals are controlled by a multichannel electronic unit with the microcontroller processing signals in real time. The dynamic phase locking of the laser system with the bandwidth of 14 kHz is demonstrated, the time of phasing is 3 – 4 ms. (fibre and integrated-optical structures)

  6. Gramicidin Channels: Versatile Tools

    NASA Astrophysics Data System (ADS)

    Andersen, Olaf S.; Koeppe, Roger E., II; Roux, Benoît

    Gramicidin channels are miniproteins in which two tryptophan-rich subunits associate by means of transbilayer dimerization to form the conducting channels. That is, in contrast to other ion channels, gramicidin channels do not open and close; they appear and disappear. Each subunit in the bilayer-spanning channel is tied to the bilayer/solution interface through hydrogen bonds that involve the indole NH groups as donors andwater or the phospholipid backbone as acceptors. The channel's permeability characteristics are well-defined: gramicidin channels are selective for monovalent cations, with no measurable permeability to anions or polyvalent cations; ions and water move through a pore whose wall is formed by the peptide backbone; and the single-channel conductance and cation selectivity vary when the amino acid sequence is varied, even though the permeating ions make no contact with the amino acid side chains. Given the plethora of available experimental information—for not only the wild-type channels but also for channels formed by amino acid-substituted gramicidin analogues—gramicidin channels continue to provide important insights into the microphysics of ion permeation through bilayer-spanning channels. For similar reasons, gramicidin channels constitute a system of choice for evaluating computational strategies for obtaining mechanistic insights into ion permeation through the more complex channels formed by integral membrane proteins.

  7. Theoretical study of reaction channels for the weakly bound complex systems created with HF, CO2, and various amines

    NASA Astrophysics Data System (ADS)

    Chen, Shyh-Jong; Chen, Cheng; Hong, Yaw-Shun

    This investigation conducted reaction channels of weakly bound complexes CO2...HF, CO2...HF...NH3, CO2...HF...NH2CH3, CO2...HF...NH(CH3)2, and CO2...HF...N(CH3)3 systems, using the Gaussian 98 package at the B3LYP/6-311++G(3df,2pd) level. The syn-fluoroformic acid or syn-fluoroformic acid plus NH3 or amine conformers are more stable than the related anti-fluoroformic acid or anti-fluoroformic acid plus NH3 or amine conformers. However, the above-mentioned weakly bound complexes are more stable than both the related syn- and anti-type fluoroformic acid or acid plus NH3 or amine conformers and their related decomposed into CO2 + HF or CO2 + NHR3F (RH, CH3) combined molecular systems. Five reaction channels of the weakly bound complexes exist. Each channel includes weakly bound complexes and their related above-mentioned systems. Moreover, each reaction channel contains two transition states. The transition state between the weakly bound complex and anti-fluoroformic acid type structure (T13) is significantly higher than that of internal rotation (T23) between syn- and anti-FCO2H (or FCO2H...NR3) structures. However, the above-mentioned T13 can significantly decrease its energy by adding the third molecule NH3 or NR3 (RH or CH3). The more CH3 that is substituted in NR3 of the reaction channel, the lower the activation energy of the transition state in the system is affected.

  8. Development of nine-channel 10-micrometer (Hg, Cd)Te pushbroom IR/CCD system

    NASA Technical Reports Server (NTRS)

    White, W. J.; Wasa, S.

    1977-01-01

    The engineering development of the 9-channel detector array is documented. The development of the array demonstrates the feasibility of a self scanned multi-element infrared detector focal plane. Procedures for operating the array are outlined.

  9. Photoacoustic imaging of brachytherapy seeds using a channel-domain ultrasound array system

    NASA Astrophysics Data System (ADS)

    Harrison, Tyler; Zemp, Roger J.

    2011-03-01

    Brachytherapy is a technique commonly used in the treatment of prostate cancer that relies on the precise placement of small radioactive seeds near the tumor location. The advantage of this technique over traditional radiation therapies is that treatment can be continuous and uniform, resulting in fewer clinic visits and a shorter treatment duration. Two important phases of this treatment are needle guidance for implantation, and post-placement verification for dosimetry. Ultrasound is a common imaging modality used for these purposes, but it can be difficult to distinguish the seeds from surrounding tissues, often requiring other imaging techniques such as MRI or CT. Photoacoustic imaging may offer a viable alternative. Using a photoacoustic system based on an L7- 4 array transducer and a realtime ultrasound array system capable of parallel channel data acquisition streamed to a multi-core computer via PCI-express, we have demonstrated imaging of these seeds at an ultrasound depth of 16 mm and laser penetration depths ranging up to 50 mm in chicken tissue with multiple optical wavelengths. Ultrasound and photoacoustic images are coregistered via an interlaced pulse sequence. Two laser pulses are used to form a photoacoustic image, and at these depths, the brachytherapy seeds are detected with a signal-to-noise ratio of over 26dB. To obtain this result, 1064nm light was used with a fluence of 100mJ/cm2, the ANSI limit for human skin exposure at this wavelength. This study demonstrates the potential for photoacoustic imaging as a candidate technology for brachytherapy seed placement guidance and verification.

  10. Multi-channel Data Acquisition System for a 500 m DC HTS Power Cable in Ishikari

    NASA Astrophysics Data System (ADS)

    Ivanov, Yury V.; Chikumoto, Noriko; Watanabe, Hirofumi; Takano, Hirohisa; Inoue, Noriyuki; Yamaguchi, Satarou

    Reduction of heat penetrating into the cryogenic region is the important method of optimization of superconducting devices. In the cases of short-range power transmission lines and compact HTS devices like magnets, the heat leakage through current leads is relatively large. In order to decrease this contribution, current leads equipped with Peltier elements can be used. The mentioned technology is being actively developed in the Chubu University. Commercial samples of Peltier current leads are installed at the terminals of 500-meter DC HTS cable in Ishikari (Hokkaido). This cable is designed for 5 kA. The inner conducting layer consists of 37 DI-BSCCO HTS tapes from Sumitomo Electric Industries, Ltd. with a critical current of 180 A; and the outer one consists of 35 tapes of the same type. Each end of the cable's tape is connected to the individual Peltier current lead. Accordingly, each of the two terminals is equipped with 72 Peltier current leads, 144 pieces in total. In order to examine behavior of the current leads in detail, each piece is supplied with two thermocouples; there are also voltage taps on feedthrough and on HTS tape end. In addition, current through Peltier current lead can be measured by means of individual current transformer. The hardware part of the data acquisition system includes four Keithley 3706A multimeters equipped with 60-channel model 3724 FET multiplexer cards. Therefore, 144 data blocks are formed. Furthermore, there are 72 measurements of a voltage drop across HTS tape. Sampling period is set to be 3 s. The program part of the data acquisition system was written using LabVIEW software solution (National Instruments Corp.).

  11. Development of a 150 000 channel MSGC tracking system for the experiment HERA-B

    NASA Astrophysics Data System (ADS)

    Zeuner, T.

    1997-02-01

    The universities of Heidelberg, Siegen and Zürich are preparing the inner tracker of the HERA-B experiment at DESY designed to measure CP violation in B meson decays. The system consists of 200 MSGC chambers of sizes up to 30 × 30 cm 2 with a total of 150 000 electronic channels. Rates up to 10 4 s -1 mm -2 have to be handled. The gold electrodes (300 μm pitch) are produced by a lift-off process on an alkali-free glass (300 μm thick). The glass is CVD coated with amorphous carbon with a surface resistivity of 10 14ω/□. It provides the required lifetime of 5 years with an integrated charge of 30 mC per cm of the anode length. Gains > 5000 are obtained. The efficiency is greater than 99% with negligible noise rate. Measures to avoid deterioration of the anodes by discharges caused by heavy ionizing particles are discussed. The MSGC detectors are connected to hybrid electronics via Kapton foils. A special bonding machine has been built which allows the adjustment by a video system and the chariots moved by micrometer screws and contains electronically steered glue dispenser and pressure pistons. Members of the collaboration are: T. Beckmann, C. Bresch, H.-B. Dreis, F. Eisele, S. Feuerstack, S. Hausmann, A. Hölscher, T. Hott, A. Lange, A. Maag, V. Myalitsin, P. Robmann, B. Schmidt, S. Schmidt, S. Steiner, U. Straumann, P. Truöl, S. Visbeck, A.-H. Walenta, T. Walter, U. Werthenbach, G. Zech and T. Zeuner.

  12. Fading channel simulator

    SciTech Connect

    Argo, P.E.; Fitzgerald, T.J.

    1991-12-31

    This invention relates to high frequency (HF) radio signal propagation through fading channels and, more particularly, to simulation of fading channels in order to characterize HF radio system performance in transmitting and receiving signals through such fading channels. Fading channel effects on a transmitted communication signal are simulated with both frequency and time variations using a channel scattering function to affect the transmitted signal. A conventional channel scattering function is converted to a series of channel realizations by multiplying the square root of the channel scattering function by a complex number of which the real and imaginary parts are each independent variables. The two-dimensional inverse-FFT of this complex-valued channel realization yields a matrix of channel coefficients that provide a complete frequency-time description of the channel. The transmitted radio signal is segmented to provide a series of transmitted signal and each segment is subject to FFT to generate a series of signal coefficient matrices. The channel coefficient matrices and signal coefficient matrices are then multiplied and subjected to inverse-FFT to output a signal representing the received affected radio signal. A variety of channel scattering functions can be used to characterize the response of a transmitter-receiver system to such atmospheric effects.

  13. Group statistical channel coding dimming scheme in visible light communication system

    NASA Astrophysics Data System (ADS)

    Zhuang, Kaiyu; Huang, Zhitong; Zhang, Ruqi; Li, Jianfeng; Ji, Yuefeng

    2016-10-01

    In this paper, we propose a group statistical channel coding (GSCC) scheme, which achieves dimming by changing the ratio of the 0-1 symbol of the original data stream through probabilistic statistics method. The simulation under various brightness conditions displays that the GSCC maintains good performance comparing to PWM dimming with half satisfice of transmission rate and a larger dimming intensity. Simulation of GSCC after combining with other channel coding schemes reflects that GSCC has good compatibility to arbitrary access coded signal.

  14. Evaluation of the SHOALS 1000T Bathymetric LIDAR System for Monitoring Channel Sediment Within the Colorado River in Arizona

    NASA Astrophysics Data System (ADS)

    Davis, P. A.; Gonzales, F. M.; Brown, K. M.; Melis, T. S.

    2005-12-01

    The Grand Canyon Monitoring and Research Center of the U.S. Geological Survey monitors sediment transport and storage within the Colorado River ecosystem in Arizona in order to develop flow protocols for the Glen Canyon dam that preserve or restore aquatic and terrestrial habitats. Currently, monitoring the channel sediments is accomplished using acoustic multi-beam surveys, which are very time-consuming. We explored more efficient collection systems that could provide a 2-m point spacing and a vertical accuracy of 25 cm or better. The dual-beam SHOALS 1000T LIDAR system, which simultaneously collects bathymetric and topographic data, could meet these requirements if flown at a 300 m altitude. This low altitude required this fixed-wing system to be modified for helicopter collection to navigate the sinuous, steep-walled canyon. We tested the helicopter-based SHOALS on two segments of the Colorado River - the San Juan River confluence at Lake Powell and the southern portion of Glen Canyon near Lees Ferry. The test flights occurred in late November after a high-flow dam experiment. Early winter storms injected such large volumes of sediment into the unmanaged San Juan River that the SHOALS green laser could not penetrate the water's surface. The water at Lees Ferry was relatively clear (Secchi depths of 7-7.5 m) because there are no tributaries between Lees Ferry and Glen Canyon dam and because the dam maintained a low steady flow for a week following the high-flow experiment in order for ground and aerial surveys to collect monitoring data. At a 300 m altitude, the SHOALS scanner produced a 60-m ground swath. Seven separate flight lines were collected - more than necessary to cover the 100-m-wide channel. Three GPS stations were operated within 30 km of the test flights. Within the areas of overlap between each pair of the seven SHOALS flight lines we found the reproducibility of the SHOALS data to be 19 cm in the channel and 21 cm on land. At Lees Ferry, 20 land

  15. An efficient ASIC implementation of 16-channel on-line recursive ICA processor for real-time EEG system.

    PubMed

    Fang, Wai-Chi; Huang, Kuan-Ju; Chou, Chia-Ching; Chang, Jui-Chung; Cauwenberghs, Gert; Jung, Tzyy-Ping

    2014-01-01

    This is a proposal for an efficient very-large-scale integration (VLSI) design, 16-channel on-line recursive independent component analysis (ORICA) processor ASIC for real-time EEG system, implemented with TSMC 40 nm CMOS technology. ORICA is appropriate to be used in real-time EEG system to separate artifacts because of its highly efficient and real-time process features. The proposed ORICA processor is composed of an ORICA processing unit and a singular value decomposition (SVD) processing unit. Compared with previous work [1], this proposed ORICA processor has enhanced effectiveness and reduced hardware complexity by utilizing a deeper pipeline architecture, shared arithmetic processing unit, and shared registers. The 16-channel random signals which contain 8-channel super-Gaussian and 8-channel sub-Gaussian components are used to analyze the dependence of the source components, and the average correlation coefficient is 0.95452 between the original source signals and extracted ORICA signals. Finally, the proposed ORICA processor ASIC is implemented with TSMC 40 nm CMOS technology, and it consumes 15.72 mW at 100 MHz operating frequency. PMID:25570831

  16. An efficient ASIC implementation of 16-channel on-line recursive ICA processor for real-time EEG system.

    PubMed

    Fang, Wai-Chi; Huang, Kuan-Ju; Chou, Chia-Ching; Chang, Jui-Chung; Cauwenberghs, Gert; Jung, Tzyy-Ping

    2014-01-01

    This is a proposal for an efficient very-large-scale integration (VLSI) design, 16-channel on-line recursive independent component analysis (ORICA) processor ASIC for real-time EEG system, implemented with TSMC 40 nm CMOS technology. ORICA is appropriate to be used in real-time EEG system to separate artifacts because of its highly efficient and real-time process features. The proposed ORICA processor is composed of an ORICA processing unit and a singular value decomposition (SVD) processing unit. Compared with previous work [1], this proposed ORICA processor has enhanced effectiveness and reduced hardware complexity by utilizing a deeper pipeline architecture, shared arithmetic processing unit, and shared registers. The 16-channel random signals which contain 8-channel super-Gaussian and 8-channel sub-Gaussian components are used to analyze the dependence of the source components, and the average correlation coefficient is 0.95452 between the original source signals and extracted ORICA signals. Finally, the proposed ORICA processor ASIC is implemented with TSMC 40 nm CMOS technology, and it consumes 15.72 mW at 100 MHz operating frequency.

  17. Orbital angular momentum in four channel spatial domain multiplexing system for multi-terabit per second communication architectures

    NASA Astrophysics Data System (ADS)

    Murshid, Syed H.; Muralikrishnan, Hari P.; Kozaitis, Samuel P.

    2012-06-01

    Bandwidth increase has always been an important area of research in communications. A novel multiplexing technique known as Spatial Domain Multiplexing (SDM) has been developed at the Optronics Laboratory of Florida Institute of Technology to increase the bandwidth to T-bits/s range. In this technique, space inside the fiber is used effectively to transmit up to four channels of same wavelength at the same time. Experimental and theoretical analysis shows that these channels follow independent helical paths inside the fiber without interfering with each other. Multiple pigtail laser sources of exactly the same wavelength are used to launch light into a single carrier fiber in a fashion that resulting channels follow independent helical trajectories. These helically propagating light beams form optical vortices inside the fiber and carry their own Orbital Angular Momentum (OAM). The outputs of these beams appear as concentric donut shaped rings when projected on a screen. This endeavor presents the experimental outputs and simulated results for a four channel spatially multiplexed system effectively increasing the system bandwidth by a factor of four.

  18. Sequence stratigraphic model and Evolution of the Channelized depositional systems during Miocene in Ulleung Basin southeastern margin, East Sea

    NASA Astrophysics Data System (ADS)

    Baek, Y.; Lee, S. H.; Kim, H. J.; Jou, H. T.

    2015-12-01

    The southwestern margin of Ulleung Basin consists of broad and gentle slope continental shelf and shelf break. The sedimentary succession of the continental shelf is divided into nine sequences (S1-S9). The sedimentary succession is consists of the lower pro-graded sequences (from S2 to S6; 16.5-8.2 Ma) and upper channelized depositional sequences (S7 and S8; 8.2-5.5 Ma) in the Miocene. It progressively thickens northeast ward, suggesting a significant contribution of sediments into the basin margin. The channelized depositional system of S7 is divided into two subunits in which lower boundaries of each subunit are indicated by erosional truncation and channel incision. The underlying subunit 1 has two main streams; the progressive directions are to the NNE (a) and ENE (b). The main stream of subunit 2, developed after giving rise to the low-relief topography of the subunit 1, is only overlapping main stream (a) of subunit 1. The gentle sloped proximal-middle zone has different internal reflector, subunit 1 is characterized by parallel to chaotic reflections, whereas the subunit 2 is dominated by continuous and inclined reflectors, which can be interpreted that sediments supply is increase in subunit 2 than subunit 1. The steep sloped distal zone of channelized depositional systems connected the shelf break. The slope gradient is more slanted subunit 2 than 1. The internal structures are dis-continuous and inclined chaotic internal reflectors, which is interpreted mass transport deposits (MTDs). The slope failures commonly start near the shelf break, but some others are connected perpendicular to the main stream. The upper boundary of subunit 2 is truncated by transgressive surface. The stacking pattern of sequence 7 suggests the type-1 sequence controlled by sea level change, and the internal erosional surface in the channelized depositional systems can be interpreted that formed by tectonic or relative sea level flocculation during late Miocene in East Sea.

  19. Development of a 512-Channel Module for Digital X-Ray Imaging Systems with Silicon Strip Detectors

    SciTech Connect

    Bolanos, L.; Cabal, A. E.; Grybos, P.; Maj, P.; Swientek, K.; Szczygiel, R.; Marzari, A.; Prino, F.; Ramello, L.

    2008-08-11

    We present the development of a 512-channel module for high counting rate digital X-ray imaging systems. The module consists of 512 silicon micro-strips equipped with 8 64-channel readout ASICs called DEDIX. The detectors of 300 {mu}m thickness have strips with 100 micron pitch and strip length of 1 or 2 cm. Detectors were designed with the possibility of choosing the cutting edge distance from the active area in the range from 60 {mu}m down to 20 {mu}m. To obtain good detection efficiency at the relevant energies (10-50 keV) the module works in edge-on configuration: strips are oriented parallel to the incoming X-ray beam. The DEDIX ASIC has a binary readout architecture. Each channel is built of a charge sensitive amplifier (CSA) with pole-zero cancellation circuit, a shaper, two independent discriminators and two independent 20-bit counters. Internal correction DAC implemented in each channel independently ensures a low spread of discriminator effective threshold. This module has been characterized for noise and matching performance having in mind possible future applications like dual energy mammography and angiography. An equivalent noise charge is below 210 el rms for a 1 cm long strip detector and below 250 el. rms for 2 cm long strip detector with 100 {mu}m pitch. The spread of discriminator effective threshold for 512 channels is 16 el. rms, while the high counting rate performance has been demonstrated by the measurement up to 1 MHz average rate of input signals per single channel.

  20. Designing a Low-noise, High-resolution, and Portable Four Channel Acquisition System for Recording Surface Electromyographic Signal.

    PubMed

    Pashaei, Akbar; Yazdchi, Mohammad Reza; Marateb, Hamid Reza

    2015-01-01

    In current years, the application of biopotential signals has received a lot of attention in literature. One of these signals is an electromyogram (EMG) generated by active muscles. Surface EMG (sEMG) signal is recorded over the skin, as the representative of the muscle activity. Since its amplitude can be as low as 50 μV, it is sensitive to undesirable noise signals such as power-line interferences. This study aims at designing a battery-powered portable four-channel sEMG signal acquisition system. The performance of the proposed system was assessed in terms of the input voltage and current noise, noise distribution, synchronization and input noise level among different channels. The results indicated that the designed system had several inbuilt operational merits such as low referred to input noise (lower than 0.56 μV between 8 Hz and 1000 Hz), considerable elimination of power-line interference and satisfactory recorded signal quality in terms of signal-to-noise ratio. The muscle conduction velocity was also estimated using the proposed system on the brachial biceps muscle during isometric contraction. The estimated values were in then normal ranges. In addition, the system included a modular configuration to increase the number of recording channels up to 96. PMID:26951952

  1. Designing a Low-noise, High-resolution, and Portable Four Channel Acquisition System for Recording Surface Electromyographic Signal

    PubMed Central

    Pashaei, Akbar; Yazdchi, Mohammad Reza; Marateb, Hamid Reza

    2015-01-01

    In current years, the application of biopotential signals has received a lot of attention in literature. One of these signals is an electromyogram (EMG) generated by active muscles. Surface EMG (sEMG) signal is recorded over the skin, as the representative of the muscle activity. Since its amplitude can be as low as 50 μV, it is sensitive to undesirable noise signals such as power-line interferences. This study aims at designing a battery-powered portable four-channel sEMG signal acquisition system. The performance of the proposed system was assessed in terms of the input voltage and current noise, noise distribution, synchronization and input noise level among different channels. The results indicated that the designed system had several inbuilt operational merits such as low referred to input noise (lower than 0.56 μV between 8 Hz and 1000 Hz), considerable elimination of power-line interference and satisfactory recorded signal quality in terms of signal-to-noise ratio. The muscle conduction velocity was also estimated using the proposed system on the brachial biceps muscle during isometric contraction. The estimated values were in then normal ranges. In addition, the system included a modular configuration to increase the number of recording channels up to 96. PMID:26951952

  2. Expression of a Diverse Array of Ca2+-Activated K+ Channels (SK1/3, IK1, BK) that Functionally Couple to the Mechanosensitive TRPV4 Channel in the Collecting Duct System of Kidney

    PubMed Central

    Li, Yue; Hu, Hongxiang; Butterworth, Michael B.; Tian, Jin-Bin; Zhu, Michael X.; O’Neil, Roger G.

    2016-01-01

    The voltage- and Ca2+-activated, large conductance K+ channel (BK, maxi-K) is expressed in the collecting duct system of kidney where it underlies flow- and Ca2+-dependent K+ excretion. To determine if other Ca2+-activated K+ channels (KCa) may participate in this process, mouse kidney and the K+-secreting mouse cortical collecting duct (CCD) cell line, mCCDcl1, were assessed for TRPV4 and KCa channel expression and cross-talk. qPCR mRNA analysis and immunocytochemical staining demonstrated TRPV4 and KCa expression in mCCDcl1 cells and kidney connecting tubule (CNT) and CCD. Three subfamilies of KCa channels were revealed: the high Ca2+-binding affinity small-conductance SK channels, SK1and SK3, the intermediate conductance channel, IK1, and the low Ca2+-binding affinity, BK channel (BKα subunit). Apparent expression levels varied in CNT/CCD where analysis of CCD principal cells (PC) and intercalated cells (IC) demonstrated differential staining: SK1:PCIC, IK1:PC>IC, BKα:PC = IC, and TRPV4:PC>IC. Patch clamp analysis and fluorescence Ca2+ imaging of mCCDcl1 cells demonstrated potent TRPV4-mediated Ca2+ entry and strong functional cross-talk between TRPV4 and KCa channels. TRPV4-mediated Ca2+ influx activated each KCa channel, as evidenced by selective inhibition of KCa channels, with each active KCa channel enhancing Ca2+ entry (due to membrane hyperpolarization). Transepithelial electrical resistance (TEER) analysis of confluent mCCDcl1 cells grown on permeable supports further demonstrated this cross-talk where TRPV4 activation induce a decrease in TEER which was partially restored upon selective inhibition of each KCa channel. It is concluded that SK1/SK3 and IK1 are highly expressed along with BKα in CNT and CCD and are closely coupled to TRPV4 activation as observed in mCCDcl1 cells. The data support a model in CNT/CCD segments where strong cross talk between TRPV4-mediated Ca2+ influx and each KCa channel leads to enhance Ca2+ entry which

  3. 47-channel burst-mode recording hydrophone system enabling measurements of the dynamic echolocation behavior of free-swimming dolphins.

    PubMed

    Starkhammar, Josefin; Amundin, Mats; Nilsson, Johan; Jansson, Tomas; Kuczaj, Stan A; Almqvist, Monica; Persson, Hans W

    2009-09-01

    Detailed echolocation behavior studies on free-swimming dolphins require a measurement system that incorporates multiple hydrophones (often >16). However, the high data flow rate of previous systems has limited their usefulness since only minute long recordings have been manageable. To address this problem, this report describes a 47-channel burst-mode recording hydrophone system that enables highly resolved full beamwidth measurements on multiple free-swimming dolphins during prolonged recording periods. The system facilitates a wide range of biosonar studies since it eliminates the need to restrict the movement of animals in order to study the fine details of their sonar beams.

  4. Hydromorphological parameters of natural channel behavior in conditions of the Hercynian System and the flysch belt of the Western Carpathians on the territory of the Czech Republic

    NASA Astrophysics Data System (ADS)

    Kujanová, Kateřina; Matoušková, Milada; Kliment, Zdeněk

    2016-04-01

    A fundamental prerequisite for assessing the current ecological status of streams is the establishment of reference conditions for each stream type that serve as a benchmark. The hydromorphological reference conditions reflect the natural channel behavior, which is extremely variable. Significant parameters of natural channel behavior were determined using a combination of four selected statistical methods: Principal Component Analysis, Agglomerative Hierarchical Clustering, correlation, and regression. Macroscale analyses of data about altitude, stream order, channel slope, valley floor slope, sinuosity, and characteristics of the hydrological regime were conducted for 3197 reaches of major rivers in the Czech Republic with total length of 15,636 km. On the basis of selected significant parameters and their threshold values, channels were classified into groups of river characteristics based on shared behaviors. The channel behavior within these groups was validated using hydromorphological characteristics of natural channels determined during field research at reference sites. Classification of channels into groups confirmed the fundamental differences between channel behavior under conditions of the Hercynian System and the flysch belt of the Western Carpathians in the Czech Republic and determined a specific group in the flattened high areas of mountains in the Bohemian Massif. Validating confirmed the distinctions between groups of river characteristics and the uniqueness of each one; it also emphasized the benefits of using qualitative data and riparian zone characteristics for describing channel behavior. Channel slope, entrenchment ratio, bed structure, and d50 were determined as quantitative characteristics of natural channel behavior.

  5. Porous channels in the cuticle of the head-arrester system in dragon/damselflies (Insecta:Odonata).

    PubMed

    Gorb, S N

    The ultrastructure of the porous channels (PC) of the postcervical sclerite (SPC), which provides additional head fixation to the neck in adult odonates, was studied using TEM and high resolution SEM microscopy. Single chitin-protein microfibrils, about 0.14 micron thick, are arranged into channels with cylinder-like shapes. The axial rod of the chitin fiber (0.04 micron thick) is located in the center of the cylinder. The orientation of the axial rods was three-dimensionally demonstrated after dissolving the protein cover with NaOH. The PCs are arranged vertically to the surface and pass from the epidermal cells through all the cuticular layers to the surface of the cuticle. In the exo- and endocuticle, the PCs are usually oval in cross-section and about 0.3 micron thick. In the endocuticle, the cross-sectional area of the PCs varies widely, from 0.01-0.15 micron2. The shape of the PC is determined by the macromolecular organization of the chitin-protein microfibrils: the long axis of the channel is orientated parallel to the axis of the preferred orientation of the cuticular microfibrils. The microfibrils tend to follow the line of the channel very closely. In fractures orientated perpendicular to the surface, the PC resembles a ribbon-like construction, which was clearly demonstrated by casts. The strongly parallel orientation of PCs in the deep layers of the cuticle changes within the microtrichia (MT), and they begin to be curved. Numerous PCs pass through the microtrichium, and most of them end on its side wall. PCs usually contain channel filaments about 0.09 micron thick. Usually, a single channel contained one filament, but channels located in the deep layers of the endocuticle have from one to five single filaments. The filaments were observed in the intact cuticle and in the cuticle enzymatically treated with chitinase, while in the cuticle treated with NaOH filaments were absent. The porous channel system of the odonate arrester is interpreted as a

  6. A birdcage model for the Chinese Meridian System: part I. A channel as a transmission line.

    PubMed

    Yung, Kaung-Ti

    2004-01-01

    The concept of Qi and the concept of channel are so closely related that they must be defined and comprehended simultaneously in a coordinated fashion. Once the nature of Qi is established in terms of physics, we may be able to explain the functional role that the channels play, as well as explain other Chinese medical terminology with a language of modem science. Based on the low electrical impedance characteristics of acupoints, we propose that the meridian channel is equivalent to an electromagnetic transmission line and the Qi is the electromagnetic (EM) standing wave riding on the line, with acupoints as its nodes. The standing wave within each segment of the channel separated by acupoints is in natural oscillation thus the segment may be analyzed as a lambda/4 open circuit that behaves like a series RLC resonator. Acupuncture until De Qi is effectively equivalent to charging the capacitor Ceq of the RLC resonator in the transmission line. The mechanism of bu and xie are charging or discharging the capacitor to bring the capacititive (or inductive) behavior of the segment back to that of the resonant state. Kirlian photograph may serve as a visual observation of the EM waves on channels. PMID:15633816

  7. Numerical modeling and simulation of hot air jet anti-icing system employing channels for enhanced heat transfer

    NASA Astrophysics Data System (ADS)

    Ahmed, Kamran Zaki

    Aircraft icing is a serious concern for the aviation community since it is one of the major causes of fatal aircraft accidents. Aircrafts use different anti-icing systems and one such system is the hot-air anti-icing system, which utilizes hot-air from the engine compressor bleed to heat critical aircraft surfaces and prevent ice formation. Numerous experimental and numerical studies have been performed to increase the efficiency of the hot-air jet based anti-icing systems. Most of the investigations have focused on either orifice design or the impingement region of target surface geometry. Since the impingement surface heat transfer drops off sharply past the stagnation region, investigators have studied the use of multiple jets to enhance surface heat transfer over a larger area. However, use of multiple jets is a further strain on engine resources. One way to conserve engine resources is to use single jet in conjunction with various geometric and physical mechanisms to enhance heat transfer. The current study focuses on enhancing heat transfer using a single jet and a channel. The study investigates the effect of channel's height, inlet location and Reynolds number on heat transfer characteristics in terms of average Nusselt number distribution along the impingement surface. The commercial CFD code, FLUENT, is used to simulate the different cases. Results indicate that the heat transfer depends strongly on height and width of channel, jet-to-target spacing, inlet angle and jet Reynolds number.

  8. Steady state reach-scale theory for radioactive tracer concentration in a simple channel/floodplain system

    NASA Astrophysics Data System (ADS)

    Lauer, J. Wesley; Willenbring, Jane

    2010-11-01

    A steady state analytical model is presented for reach-scale variation in the concentration of a decaying radioactive tracer associated with sediment particles that regularly pass through an off-channel floodplain. The floodplain is represented as a series of well-mixed sediment reservoirs that continually exchange sediment with the channel. The model allows for tributary input and valley-wide aggradation or degradation. Tracer concentration depends on the upstream boundary concentration, the tracer and sediment load, floodplain geometry, and the rates of in-floodplain tracer production and/or decay. The theory predicts relatively modest down-channel change in the concentration of long-lived isotopes but implies that significant change may occur for (1) tracers with a short-enough half-life (such as 14C) or (2) floodplains with sediment residence times that are large enough for cosmogenic production or meteoric fallout to increase tracer concentration in the down-valley direction. The profiles are shown to be strongly dependent on the grain size distributions of both the sediment load and the floodplain. The results imply that down-channel 14C profiles have the potential to constrain Holocene bed material loads in systems with sufficient storage. The theory concisely describes the general importance of a floodplain for modifying in situ produced cosmogenic tracer concentration and can also characterize floodplain importance for fallout radioisotopes (i.e., 10Be, 210Pb, or 7Be) or organic 14C.

  9. Involvement of ATP-sensitive potassium channels and the opioid system in the anticonvulsive effect of zolpidem in mice.

    PubMed

    Sheikhi, Mehdi; Shirzadian, Armin; Dehdashtian, Amir; Amiri, Shayan; Ostadhadi, Sattar; Ghasemi, Mehdi; Dehpour, Ahmad Reza

    2016-09-01

    Zolpidem is a hypnotic medication that mainly exerts its function through activating γ-aminobutyric acid (GABA)A receptors. There is some evidence that zolpidem may have anticonvulsive effects. However, the mechanisms underlying this effect have not been elucidated yet. In the present study, we used the pentylentetrazole (PTZ)-induced generalized seizure model in mice to investigate whether zolpidem can affect seizure threshold. We also further evaluated the roles of ATP-sensitive potassium (KATP) channels as well as μ-opioid receptors in the effects of zolpidem on seizure threshold. Our data showed that zolpidem in a dose-dependent manner increased the PTZ-induced seizure threshold. The noneffective (i.e., did not significantly alter the PTZ-induced seizure threshold by itself) doses of KATP channel blocker (glibenclamide) and nonselective opioid receptor antagonist (naloxone) were able to inhibit the anticonvulsive effect of zolpidem. Additionally, noneffective doses of either KATP channel opener (cromakalim) or nonselective μ-opioid receptor agonist (morphine) in combination with a noneffective dose of zolpidem exerted a significant anticonvulsive effect on PTZ-induced seizures in mice. A combination of noneffective doses of naloxone and glibenclamide, which separately did not affect zolpidem effect on seizure threshold, inhibited the anticonvulsive effects of zolpidem. These results suggest a role for KATP channels and the opioid system, alone or in combination, in the anticonvulsive effects of zolpidem. PMID:27521722

  10. Cooperative Reformable Channel System with Unique Recognition of Small Gas Molecules in a two-dimensional ZIF-membrane

    NASA Astrophysics Data System (ADS)

    Motevalli, Benyamin; Taherifar, Neda; Liu, Zhe

    We report a cooperative reformable channel system in a coordination porous polymer, named as ZIF-L. Three types of local flexible ligands coexist in the crystal structure of this polymer, resulting in ultra-flexibility. The reformable channel is able to regulate permeation of a nonspherical guest molecule, such as N2 or CO2, based on its longer molecular dimension, which is in a striking contrast to conventional molecular sieves that regulate the shorter cross-sectional dimension of the guest molecules. Our density functional theory (DFT) calculations reveal that the guest molecule induces dynamic motion of the flexible ligands, leading to the channel reformation, and then the guest molecule reorientates itself to fit in the reformed channel. Such a unique ``induced fit-in'' mechanism causes the gas molecule to pass through 6 membered-ring windows in the c- crystal direction of ZIF-L with its longer axis parallel to the window plane. Our experimental permeance of N2 through the ZIF-L membranes is about three times greater than that of CO2, supporting the DFT simulation predictions.

  11. Using the plant vacuole as a biological system to investigate the functional properties of exogenous channels and transporters.

    PubMed

    Festa, M; Lagostena, L; Carpaneto, A

    2016-03-01

    Plant cells possess a large intracellular compartment that animal cells do not, the central vacuole, which has been investigated for a long time. The central vacuole can occupy up to 90% of the cellular volume and, differently from intracellular organelles from animal cells such as lysosomes or endosomes, it is easy to isolate. Because of its large dimension (up to 40 μm diameter) it can be successfully studied using the classical patch-clamp technique. Following the idea that the vacuolar membrane could be used as a convenient model to characterize the functional properties of channel-forming peptides, we verified that the phytotoxic lipodepsipeptide Syringopeptin 25A from Pseudomonas syringae pv syringae was able to form ionic pores in sugar beet vacuoles and we performed a detailed biophysical analysis. Recently, we extended the use of plant vacuoles to the expression and functional characterization of animal intracellular transporters, namely rat CLC-7, and channels, i.e. human TPC2. Since endo-lysosomal transporters and channels are still largely unexplored, principally because their intracellular localization renders them difficult to study, we believe that this novel approach will prove to be a powerful system for the investigation of the molecular mechanisms of exogenous transporters and channels. This article is part of a Special Issue entitled: Pore-Forming Toxins edited by Mauro Dalla Serra and Franco Gambale.

  12. Dominant geomorphic controls on channel capacity and flood risk in a hydrologically variable fluvial system

    NASA Astrophysics Data System (ADS)

    Daley, James; Croke, Jacky; Thompson, Chris; Cohen, Tim

    2016-04-01

    Traditionally, particular emphasis has been placed on the hydrological characteristics of rivers to understand the role of channel morphology in flood risk. However, in regions of high hydrological variability, the relationship between channel characteristics and flood conveyance is often highly complex. Consequently in these settings, the applicability of stream discharge or steady-state form-process relationships, may be of less use to understanding flood conveyance. In the subtropical region of southeast Queensland, Australia, rivers are characterized by highly variable flows and entrenched channel morphologies. The latter are such dramatic features, they are termed 'macrochannels'. Following the extreme flood of 2011 in the Lockyer Creek in this region, longitudinal variations in the macrochannel form were found to be a significant factor in flood conveyance. Nine reaches were identified on a basis of flood inundation extent, with significant non-linear changes in channel capacity and discharge, alternating between flood expansion and contraction zones with associated increases and decreases in flood risk. Detailed geomorphic and chronostratigraphic analyses presented here indicate that macrochannel capacity is being strongly influenced by the antecedent bedrock topography, resistant valley-fill and abrupt downstream changes in sediment delivery. A large proportion of the valley fill represents a major Late Pleistocene aggradation phase of fine-grained alluvium that overlies older Pleistocene basal sediments. Subsequent channel incision at 10 ka reoccupied a pre-existing bedrock valley and resistant Pleistocene alluvium imposed substantial controls on the capacity for lateral adjustment. Abrupt changes in sediment supply associated with the location of tributaries provide further evidence for geomorphic controls on macrochannel form and capacity. Identification of the dominant geomorphic factors influencing the overall macrochannel form highlights the relative

  13. Bit Error Rate Analysis for MC-CDMA Systems in Nakagami-[InlineEquation not available: see fulltext.] Fading Channels

    NASA Astrophysics Data System (ADS)

    Li, Zexian; Latva-aho, Matti

    2004-12-01

    Multicarrier code division multiple access (MC-CDMA) is a promising technique that combines orthogonal frequency division multiplexing (OFDM) with CDMA. In this paper, based on an alternative expression for the[InlineEquation not available: see fulltext.]-function, characteristic function and Gaussian approximation, we present a new practical technique for determining the bit error rate (BER) of multiuser MC-CDMA systems in frequency-selective Nakagami-[InlineEquation not available: see fulltext.] fading channels. The results are applicable to systems employing coherent demodulation with maximal ratio combining (MRC) or equal gain combining (EGC). The analysis assumes that different subcarriers experience independent fading channels, which are not necessarily identically distributed. The final average BER is expressed in the form of a single finite range integral and an integrand composed of tabulated functions which can be easily computed numerically. The accuracy of the proposed approach is demonstrated with computer simulations.

  14. New approach to information fusion for Lipschitz classifiers ensembles: Application in multi-channel C-OTDR-monitoring systems

    NASA Astrophysics Data System (ADS)

    Timofeev, Andrey V.; Egorov, Dmitry V.

    2016-06-01

    This paper presents new results concerning selection of an optimal information fusion formula for an ensemble of Lipschitz classifiers. The goal of information fusion is to create an integral classificatory which could provide better generalization ability of the ensemble while achieving a practically acceptable level of effectiveness. The problem of information fusion is very relevant for data processing in multi-channel C-OTDR-monitoring systems. In this case we have to effectively classify targeted events which appear in the vicinity of the monitored object. Solution of this problem is based on usage of an ensemble of Lipschitz classifiers each of which corresponds to a respective channel. We suggest a brand new method for information fusion in case of ensemble of Lipschitz classifiers. This method is called "The Weighing of Inversely as Lipschitz Constants" (WILC). Results of WILC-method practical usage in multichannel C-OTDR monitoring systems are presented.

  15. Observational fear learning involves affective pain system and Cav1.2 Ca2+ channels in ACC

    PubMed Central

    Jeon, Daejong; Kim, Sangwoo; Chetana, Mattu; Jo, Daewoong; Ruley, H Earl; Lin, Shih-Yao; Rabah, Dania; Kinet, Jean-Pierre; Shin, Hee-Sup

    2010-01-01

    Fear can be acquired vicariously through social observation of others suffering from aversive stimuli. We found that mice (observers) developed freezing behavior by observing other mice (demonstrators) receive repetitive foot shocks. Observers had higher fear responses when demonstrators were socially related to themselves, such as siblings or mating partners. Inactivation of anterior cingulate cortex (ACC) and parafascicular or mediodorsal thalamic nuclei, which comprise the medial pain system representing pain affection, substantially impaired this observational fear learning, whereas inactivation of sensory thalamic nuclei had no effect. The ACC neuronal activities were increased and synchronized with those of the lateral amygdala at theta rhythm frequency during this learning. Furthermore, an ACC-limited deletion of Cav1.2 Ca2+ channels in mice impaired observational fear learning and reduced behavioral pain responses. These results demonstrate the functional involvement of the affective pain system and Cav1.2 channels of the ACC in observational social fear. PMID:20190743

  16. Observational fear learning involves affective pain system and Cav1.2 Ca2+ channels in ACC.

    PubMed

    Jeon, Daejong; Kim, Sangwoo; Chetana, Mattu; Jo, Daewoong; Ruley, H Earl; Lin, Shih-Yao; Rabah, Dania; Kinet, Jean-Pierre; Shin, Hee-Sup

    2010-04-01

    Fear can be acquired vicariously through social observation of others suffering from aversive stimuli. We found that mice (observers) developed freezing behavior by observing other mice (demonstrators) receive repetitive foot shocks. Observers had higher fear responses when demonstrators were socially related to themselves, such as siblings or mating partners. Inactivation of anterior cingulate cortex (ACC) and parafascicular or mediodorsal thalamic nuclei, which comprise the medial pain system representing pain affection, substantially impaired this observational fear learning, whereas inactivation of sensory thalamic nuclei had no effect. The ACC neuronal activities were increased and synchronized with those of the lateral amygdala at theta rhythm frequency during this learning. Furthermore, an ACC-limited deletion of Ca(v)1.2 Ca(2+) channels in mice impaired observational fear learning and reduced behavioral pain responses. These results demonstrate the functional involvement of the affective pain system and Ca(v)1.2 channels of the ACC in observational social fear.

  17. Communication systems, transceivers, and methods for generating data based on channel characteristics

    DOEpatents

    Forman, Michael A; Young, Derek

    2012-09-18

    Examples of methods for generating data based on a communications channel are described. In one such example, a processing unit may generate a first vector representation based in part on at least two characteristics of a communications channel. A constellation having at least two dimensions may be addressed with the first vector representation to identify a first symbol associated with the first vector representation. The constellation represents a plurality of regions, each region associated with a respective symbol. The symbol may be used to generate data, which may stored in an electronic storage medium and used as a cryptographic key or a spreading code or hopping sequence in a modulation technique.

  18. More than 100 channel supercontinuum CW optical source with precise 25GHz spacing for 10Gbit/s DWDM systems

    NASA Astrophysics Data System (ADS)

    Wang, Jianping; Nan, Yinbo; Zhou, Xianwei

    2006-01-01

    We experimentally demonstrate the generation of supercontinuum (SC) with a 12.5GHz DFB/EAM ultrashort optical pulse broadened in the high nonlinear fiber (HNLF). Through longitudinal mode-carving of the SC spectrum, a novel multiwavelength continuous wave (CW) optical source with precise 25GHz channel spacing is realized. The bit error rate (BER) curve and eye diagram show that the multiwavelength CW optical source is promising for dense wavelength division multiplexing (DWDM) systems.

  19. The Sarcoglycan complex is expressed in the cerebrovascular system and is specifically regulated by astroglial Cx30 channels

    PubMed Central

    Boulay, Anne-Cécile; Saubaméa, Bruno; Cisternino, Salvatore; Mignon, Virginie; Mazeraud, Aurélien; Jourdren, Laurent; Blugeon, Corinne; Cohen-Salmon, Martine

    2015-01-01

    Astrocytes, the most prominent glial cell type in the brain, send specialized processes called endfeet, around blood vessels and express a large molecular repertoire regulating the cerebrovascular system physiology. One of the most striking properties of astrocyte endfeet is their enrichment in gap junction proteins Connexin 43 and 30 (Cx43 and Cx30) allowing in particular for direct intercellular trafficking of ions and small signaling molecules through perivascular astroglial networks. In this study, we addressed the specific role of Cx30 at the gliovascular interface. Using an inactivation mouse model for Cx30 (Cx30Δ/Δ; Δ means deleted allele) we showed that absence of Cx30 does not affect blood-brain barrier (BBB) organization and permeability. However, it results in the cerebrovascular fraction, in a strong upregulation of Sgcg encoding γ-Sarcoglycan (γ-SG), a member of the Dystrophin-associated protein complex (DAPC) connecting cytoskeleton and the extracellular matrix. The same molecular event occurs in Cx30T5M/T5M mutated mice, where Cx30 channels are closed, demonstrating that Sgcg regulation relied on Cx30 channel functions. We further characterized the expression of other Sarcoglycan complex (SGC) molecules in the cerebrovascular system and showed the presence of α-, β-, δ-, γ-, ε- and ζ- SG, as well as Sarcospan. Their expression was however not modified in Cx30Δ/Δ. These results suggest that a full SGC might be present in the cerebrovascular system, and that expression of one of its member, γ-SG, depends on Cx30 channels. As described in skeletal muscles, the SGC may contribute to membrane stabilization and signal transduction in the cerebrovascular system, which may therefore be regulated by Cx30 channel-mediated functions. PMID:25698924

  20. Organization of the channel-switching process in parallel computer systems based on a matrix optical switch

    NASA Technical Reports Server (NTRS)

    Golomidov, Y. V.; Li, S. K.; Popov, S. A.; Smolov, V. B.

    1986-01-01

    After a classification and analysis of electronic and optoelectronic switching devices, the design principles and structure of a matrix optical switch is described. The switching and pair-exclusion operations in this type of switch are examined, and a method for the optical switching of communication channels is elaborated. Finally, attention is given to the structural organization of a parallel computer system with a matrix optical switch.

  1. Functional importance of T-type voltage-gated calcium channels in the cardiovascular and renal system: news from the world of knockout mice.

    PubMed

    Hansen, Pernille B L

    2015-02-15

    Over the years, it has been discussed whether T-type calcium channels Cav3 play a role in the cardiovascular and renal system. T-type channels have been reported to play an important role in renal hemodynamics, contractility of resistance vessels, and pacemaker activity in the heart. However, the lack of highly specific blockers cast doubt on the conclusions. As new T-type channel antagonists are being designed, the roles of T-type channels in cardiovascular and renal pathology need to be elucidated before T-type blockers can be clinically useful. Two types of T-type channels, Cav3.1 and Cav3.2, are expressed in blood vessels, the kidney, and the heart. Studies with gene-deficient mice have provided a way to investigate the Cav3.1 and Cav3.2 channels and their role in the cardiovascular system. This review discusses the results from these knockout mice. Evaluation of the literature leads to the conclusion that Cav3.1 and Cav3.2 channels have important, but different, functions in mice. T-type Cav3.1 channels affect heart rate, whereas Cav3.2 channels are involved in cardiac hypertrophy. In the vascular system, Cav3.2 activation leads to dilation of blood vessels, whereas Cav3.1 channels are mainly suggested to affect constriction. The Cav3.1 channel is also involved in neointima formation following vascular damage. In the kidney, Cav3.1 regulates plasma flow and Cav3.2 plays a role setting glomerular filtration rate. In conclusion, Cav3.1 and Cav3.2 are new therapeutic targets in several cardiovascular pathologies, but the use of T-type blockers should be specifically directed to the disease and to the channel subtype.

  2. A portable multi-channel recording system for analysis of acceleration and angular velocity in six dimension.

    PubMed

    Yamashita, M; Yamashita, A; Ishii, T; Naruo, Y; Nagatomo, M

    1998-11-01

    A portable recording system was developed for analysis of more than three analog signals collected in field works. Stereo audio recorder, available as consumer products, was made use for a core cornponent of the system. For the two tracks of recording, a multiplexed analog signal is stored on one track, and reference code on the other track. The reference code indicates the start of one cycle for multiplexing and swiching point of each channel. Multiplexed signal is playbacked and decoded with a reference of the code to reconstruct original profiles of the signal. Since commercial stereo recorders have cut DC component off, a fixed reference voltage is inserted in the sequence of multiplexing. Change of voltage at switching from the reference to the data channel is measured from playbacked signal to get the original data with its DC component. Movement of vehicles and human head were analyzed by the system. It was verified to be capable to record and analyze multi-channel signal at a sampling rate more than 10Hz.

  3. Numerical study of water flow in a system of two basins connected by a channel with periodic forcing

    NASA Astrophysics Data System (ADS)

    Lopez Sanchez, Erick Javier; Ruiz Chavarria, Gerardo

    2010-11-01

    In oceanography the transport of particles is a frecuent phenomenon, for instance ocean currents carry the plankton from one place to another. In shallow waters drag and depositation of sand can affect positively or negatively certain human activities, such as the navigation near the coast; on the other hand, sand banks can help to mitigate the force with which a tsunami approaches a populated coastline. We study the flow of water in a system of two basins connected by a channel, generated by a periodic forcing that simulates the tidal force. The simulation is done by solving the system of equations in stream function (ψ ) - vorticity (φ ) formulation, obtained from the Navier-Stokes and continuity in two dimensions. A pseudo-spectral method based on polynomials Chebyshev is used. The tidal forcing is reflected in the fact that Reynolds number becomes time dependent. We obtained results that are consistent with previous works (like: Wells, M. G. and Van Heijst, G.J.F., Dynamics of Atmospheres and Oceans, 37 (2003) 223-244). For example the formation and displacement of a dipole at the exit of the channel is observed. The velocity field obtained numerically is used to study the transport of particles by the flow, where the dipole moves away from the channel output or return to it, depending on the geometry of the system and period occurrence of the phenomenon.

  4. Designing Effective Persuasive Systems Utilizing the Power of Entanglement: Communication Channel, Strategy & Affect

    ERIC Educational Resources Information Center

    Li, Haiqing

    2010-01-01

    With rapid advancements in information and communication technologies, computer-mediated communication channels such as email, web, mobile smart-phones with SMS, social networking websites (Facebook), multimedia websites, and OEM devices provide users with multiple technology choices to seek information. However, no study has compared the…

  5. Arroyo channel head evolution in a flash-flood-dominated discontinuous ephemeral stream system

    USGS Publications Warehouse

    DeLong, Stephen B.; Johnson, Joel P.L.; Whipple, Kelin X.

    2014-01-01

    We study whether arroyo channel head retreat in dryland discontinuous ephemeral streams is driven by surface runoff, seepage erosion, mass wasting, or some combination of these hydrogeomorphic processes. We monitored precipitation, overland flow, soil moisture, and headcut migration over several seasonal cycles at two adjacent rangeland channel heads in southern Arizona. Erosion occurred by headward retreat of vertical to overhanging faces, driven dominantly by surface runoff. No evidence exists for erosion caused by shallow-groundwater–related processes, even though similar theater-headed morphologies are sometimes attributed to seepage erosion by emerging groundwater. At our field site, vertical variation in soil shear strength influenced the persistence of the characteristic theater-head form. The dominant processes of erosion included removal of grains and soil aggregates during even very shallow (1–3 cm) overland flow events by runoff on vertical to overhanging channel headwalls, plunge-pool erosion during higher-discharge runoff events, immediate postrunoff wet mass wasting, and minor intra-event dry mass wasting on soil tension fractures developing subparallel to the headwall. Multiple stepwise linear regression indicates that the migration rate is most strongly correlated with flow duration and total precipitation and is poorly correlated with peak flow depth or time-integrated flow depth. The studied channel heads migrated upslope with a self-similar morphologic form under a wide range of hydrological conditions, and the most powerful flash floods were not always responsible for the largest changes in landscape form in this environment. 

  6. Relationships among rotational and conventional grazing systems, stream channels, and macroinvertebrates

    USGS Publications Warehouse

    Raymond, K.L.; Vondracek, B.

    2011-01-01

    Cattle grazing in riparian areas can reduce water quality, alter stream channel characteristics, and alter fish and macroinvertebrate assemblage structure. The U.S. Department of Agriculture, Natural Resources Conservation Services has recommended Rotational Grazing (RG) as an alternative management method on livestock and dairy operations to protect riparian areas and water quality. We evaluated 13 stream channel characteristics, benthic macroinvertebrate larvae (BML), and chironomid pupal exuviae (CPE) from 18 sites in the Upper Midwest of the United States in relation to RG and conventional grazing (CG). A Biotic Composite Score comprised of several macroinvertebrate metrics was developed for both the BML assemblage and the CPE assemblage. Multi-Response Permutation Procedures (MRPP) indicated a significant difference in stream channel characteristics between RG and CG. Nonmetric Multidimensional Scaling indicated that RG sites were associated with more stable stream banks, higher quality aquatic habitat, lower soil compaction, and larger particles in the streambed. However, neither MRPP nor Mann-Whitney U tests demonstrated a difference in Biotic Composite Scores for BML or CPE along RG and CG sites. The BML and CPE metrics were significantly correlated, indicating that they were likely responding to similar variables among the study sites. Although stream channel characteristics appeared to respond to grazing management, BML and CPE may have responded to land use throughout the watershed, as well as local land use. ?? 2011 Springer Science+Business Media B.V. (outside the USA).

  7. Mobility Channel Preference and Educational Aspirations in a Sponsored Mobility System.

    ERIC Educational Resources Information Center

    Yogev, Abraham; Schrift, Ruth

    1983-01-01

    Used path analysis to study the educational aspirations of secondary school students in Costa Rica (N=346) and a second combined sample of students and dropouts (N=202). Results showed that preference for the Educational Mobility Channel mainly affects academic aspirations for males. Females' aspirations appear related to sex role socialization.…

  8. The Martian hydrologic system: Multiple recharge centers at large volcanic provinces and the contribution of snowmelt to outflow channel activity

    NASA Astrophysics Data System (ADS)

    Russell, Patrick S.; Head, James W.

    2007-02-01

    Global recharge of the martian hydrologic system has traditionally been viewed as occurring through basal melting of the south polar cap. We conclude that regional recharge of a groundwater system at the large volcanic provinces, Elysium and Tharsis, is also very plausible and has several advantages over a south polar recharge source in providing a more direct, efficient supply of water to the outflow channel source regions surrounding these areas. This recharge scenario is proposed to have operated concurrently with and within the context of a global cryosphere-hydrosphere system of the subsurface characteristic of post-Noachian periods. To complement existing groundwater flow modeling studies, we examine geologic evidence and possible mechanisms for accumulation of water at high elevations on the volcanic rises, such as melting snow, infiltration, and increased effective permeability of the subsurface between the recharge zone and outflow source. Evidence for the presence of large Amazonian-aged cold-based piedmont glaciers on the Tharsis Montes has been well documented. Climate modeling predicts snow accumulation on high volcanic rises at obliquities thought to be typical over much of martian history. Thermal gradients causing basal melting of snowpack over 1 km thick could provide several kg m -2 yr -1 of water, charging a volume equivalent to the pore space in a square meter column of subsurface in less than 1.5×10 5 yr. In order to account for estimated outflow channel volumes, the subsurface volume above the elevation of the outflow channels must be charged several times over the area of Tharsis. Complete aquifer recharge can be accomplished in ˜0.3-2 My through the snowpack melting mechanism at Tharsis and in ˜5×10 4 years for channel requirements at Elysium. Abundant radial dikes emanating from large martian volcanic rises can crack and/or melt the cryosphere, initiating water outflow and creating anisotropies that can channel subsurface water from a

  9. Regulation of epithelial Na(+) channels by actin in planar lipid bilayers and in the Xenopus oocyte expression system.

    PubMed

    Jovov, B; Tousson, A; Ji, H L; Keeton, D; Shlyonsky, V; Ripoll, P J; Fuller, C M; Benos, D J

    1999-12-31

    The hypothesis that actin interactions account for the signature biophysical properties of cloned epithelial Na(+) channels (ENaC) (conductance, ion selectivity, and long mean open and closed times) was tested using planar lipid bilayer reconstitution and patch clamp techniques. We found the following. 1) In bilayers, actin produced a more than 2-fold decrease in single channel conductance, a 5-fold increase in Na(+) versus K(+) permselectivity, and a substantial increase in mean open and closed times of wild-type alphabetagamma-rENaC but had no effect on a mutant form of rENaC in which the majority of the C terminus of the alpha subunit was deleted (alpha(R613X)betagamma-rENaC). 2) When alpha(R613X)betagamma-rENaC was heterologously expressed in oocytes and single channels examined by patch clamp, 12.5-pS channels of relatively low cation permeability were recorded. These characteristics were identical to those recorded in bilayers for either alpha(R613X)betagamma-rENaC or wild-type alphabetagamma-rENaC in the absence of actin. Moreover, we show that rENaC subunits tightly associate, forming either homo- or heteromeric complexes when prepared by in vitro translation or when expressed in oocytes. Finally, we show that alpha-rENaC is properly assembled but retained in the endoplasmic reticulum compartment. We conclude that actin subserves an important regulatory function for ENaC and that planar bilayers are an appropriate system in which to study the biophysical and regulatory properties of these cloned channels. PMID:10608849

  10. Retrieval of Temperature and Water Vapour from Multiple Channel Lidar Systems Using an Optimal Estimation Method

    NASA Astrophysics Data System (ADS)

    Sica, Robert; Haefele, Alexander

    2016-04-01

    While the application of optimal estimation methods (OEMs) is well-known for the retrieval of atmospheric parameters from passive instruments, active instruments have typically not employed the OEM. For instance, the measurement of temperature in the middle atmosphere with Rayleigh-scatter lidars is an important technique for assessing atmospheric change. Current retrieval schemes for these temperatures have several shortcomings which can be overcome using an OEM. Forward models have been constructed that fully characterize the measurement and allow the simultaneous retrieval of temperature, dead time and background. The OEM allows a full uncertainty budget to be obtained on a per profile basis that includes, in addition to the statistical uncertainties, the smoothing error and uncertainties due to Rayleigh extinction, ozone absorption, the lidar constant, nonlinearity in the counting system, variation of the Rayleigh-scatter cross section with altitude, pressure, acceleration due to gravity and the variation of mean molecular mass with altitude. The vertical resolution of the temperature profile is found at each height, and a quantitative determination is made of the maximum height to which the retrieval is valid. A single temperature profile can be retrieved from measurements with multiple channels that cover different height ranges, vertical resolutions and even different detection methods. The OEM employed is shown to give robust estimates of temperature consistent with previous methods, while requiring minimal computational time. Retrieval of water vapour mixing ratio from vibrational Raman scattering lidar measurements is another example where an OEM offers a considerable advantage over the standard analysis technique, with the same advantages as discussed above for Rayleigh-scatter temperatures but with an additional benefit. The conversion of the lidar measurement into mixing ratio requires a calibration constant to be employed. Using OEM the calibration

  11. A deep crustal fluid channel into the San Andreas Fault system near Parkfield, California

    USGS Publications Warehouse

    Becken, M.; Ritter, O.; Park, S.K.; Bedrosian, P.A.; Weckmann, U.; Weber, M.

    2008-01-01

    Magnetotelluric (MT) data from 66 sites along a 45-km-long profile across the San Andreas Fault (SAF) were inverted to obtain the 2-D electrical resistivity structure of the crust near the San Andreas Fault Observatory at Depth (SAFOD). The most intriguing feature of the resistivity model is a steeply dipping upper crustal high-conductivity zone flanking the seismically defined SAF to the NE, that widens into the lower crust and appears to be connected to a broad conductivity anomaly in the upper mantle. Hypothesis tests of the inversion model suggest that upper and lower crustal and upper-mantle anomalies may be interconnected. We speculate that the high conductivities are caused by fluids and may represent a deep-rooted channel for crustal and/or mantle fluid ascent. Based on the chemical analysis of well waters, it was previously suggested that fluids can enter the brittle regime of the SAF system from the lower crust and mantle. At high pressures, these fluids can contribute to fault-weakening at seismogenic depths. These geochemical studies predicted the existence of a deep fluid source and a permeable pathway through the crust. Our resistivity model images a conductive pathway, which penetrates the entire crust, in agreement with the geochemical interpretation. However, the resistivity model also shows that the upper crustal branch of the high-conductivity zone is located NE of the seismically defined SAF, suggesting that the SAF does not itself act as a major fluid pathway. This interpretation is supported by both, the location of the upper crustal high-conductivity zone and recent studies within the SAFOD main hole, which indicate that pore pressures within the core of the SAF zone are not anomalously high, that mantle-derived fluids are minor constituents to the fault-zone fluid composition and that both the volume of mantle fluids and the fluid pressure increase to the NE of the SAF. We further infer from the MT model that the resistive Salinian block

  12. Climate variability and predictability associated with the Indo-Pacific Oceanic Channel Dynamics in the CCSM4 Coupled System Model

    NASA Astrophysics Data System (ADS)

    Yuan, Dongliang; Xu, Peng; Xu, Tengfei

    2016-03-01

    An experiment using the Community Climate System Model (CCSM4), a participant of the Coupled Model Intercomparison Project phase-5 (CMIP5), is analyzed to assess the skills of this model in simulating and predicting the climate variabilities associated with the oceanic channel dynamics across the Indo-Pacific Oceans. The results of these analyses suggest that the model is able to reproduce the observed lag correlation between the oceanic anomalies in the southeastern tropical Indian Ocean and those in the cold tongue in the eastern equatorial Pacific Ocean at a time lag of 1 year. This success may be largely attributed to the successful simulation of the interannual variations of the Indonesian Throughflow, which carries the anomalies of the Indian Ocean Dipole (IOD) into the western equatorial Pacific Ocean to produce subsurface temperature anomalies, which in turn propagate to the eastern equatorial Pacific to generate ENSO. This connection is termed the "oceanic channel dynamics" and is shown to be consistent with the observational analyses. However, the model simulates a weaker connection between the IOD and the interannual variability of the Indonesian Throughflow transport than found in the observations. In addition, the model overestimates the westerly wind anomalies in the western-central equatorial Pacific in the year following the IOD, which forces unrealistic upwelling Rossby waves in the western equatorial Pacific and downwelling Kelvin waves in the east. This assessment suggests that the CCSM4 coupled climate system has underestimated the oceanic channel dynamics and overestimated the atmospheric bridge processes.

  13. Potential effects of deepening the St. Johns River navigation channel on saltwater intrusion in the surficial aquifer system, Jacksonville, Florida

    USGS Publications Warehouse

    Bellino, Jason C.; Spechler, Rick M.

    2013-01-01

    The U.S. Army Corps of Engineers (USACE) has proposed dredging a 13-mile reach of the St. Johns River navigation channel in Jacksonville, Florida, deepening it to depths between 50 and 54 feet below North American Vertical Datum of 1988. The dredging operation will remove about 10 feet of sediments from the surficial aquifer system, including limestone in some locations. The limestone unit, which is in the lowermost part of the surficial aquifer system, supplies water to domestic wells in the Jacksonville area. Because of density-driven hydrodynamics of the St. Johns River, saline water from the Atlantic Ocean travels upstream as a saltwater “wedge” along the bottom of the channel, where the limestone is most likely to be exposed by the proposed dredging. A study was conducted to determine the potential effects of navigation channel deepening in the St. Johns River on salinity in the adjacent surficial aquifer system. Simulations were performed with each of four cross-sectional, variable-density groundwater-flow models, developed using SEAWAT, to simulate hypothetical changes in salinity in the surficial aquifer system as a result of dredging. The cross-sectional models were designed to incorporate a range of hydrogeologic conceptualizations to estimate the effect of uncertainty in hydrogeologic properties. The cross-sectional models developed in this study do not necessarily simulate actual projected conditions; instead, the models were used to examine the potential effects of deepening the navigation channel on saltwater intrusion in the surficial aquifer system under a range of plausible hypothetical conditions. Simulated results for modeled conditions indicate that dredging will have little to no effect on salinity variations in areas upstream of currently proposed dredging activities. Results also indicate little to no effect in any part of the surficial aquifer system along the cross section near River Mile 11 or in the water-table unit along the cross

  14. Design and Implementation of a DSP-Based MIMO System Prototype for Real-Time Demonstration and Indoor Channel Measurements

    NASA Astrophysics Data System (ADS)

    Mostafa, Raqibul; Gozali, Ran; Palat, Ramesh Chembil; Robert, Max; Newhall, William G.; Woerner, Brian D.; Reed, Jeffrey H.

    2005-12-01

    The design and implementation of the Virginia Tech Space-Time Advanced Radio (VT-STAR), a multiple antenna element space-time (ST) processing prototype testbed, is presented. The testbed is a research tool for comparing practical and theoretical performance metrics (e.g., throughput, link reliability) in different wireless channel conditions. The prototype builds around software-defined radio (SDR) concepts on a DSP platform and provides the flexibility to implement various forms of ST techniques. Different components of the system are described in detail, including the software implementation, I/O schemes with custom hardware, and data transfer mechanisms between the DSP and the host PC. Two different example realizations are presented, a real-time demonstration and an offline measurement tool. Finally, some representative measurement results obtained in indoor environments are presented. These results show VT-STAR to be a promising tool for performing MIMO experiments and generating channel measurements that can complement simulation studies in this area.

  15. Analyzing the benefit of optical transmission systems based on Root Raised Cosine PS-QPSK and a flexible channel grid.

    PubMed

    Seck, A; Ramantanis, P; Vuong, J; Bendimerad, D F; Lepers, C; Benkelfat, B-E; Frignac, Y

    2013-05-01

    We numerically investigate the multi-channel transmission performance of Polarization Switched Quadrature Phase Shift Keying (PS-QPSK) and we compare it to the performance of Polarization-Division-Multiplexed QPSK (PDM-QPSK), using Root Raised Cosine (RRC) spectral shaping, in the context of a flexible channel grid. We point out the impact of the roll-off factor and the potential influence of different dispersion compensation scenarios. Finally, the advantage of PS-QPSK against PDM-QPSK is presented as a function of the system parameters, while we also discuss the benefit of a RRC spectral shaping against a tight filtering at the transmitter side with a 2nd order super-Gaussian-shaped filter.

  16. Cortical neural excitations in rats in vivo with using a prototype of a wireless multi-channel microstimulation system.

    PubMed

    Hayashida, Yuki; Umehira, Yuichi; Takatani, Kouki; Futami, Shigetoshi; Kameda, Seiji; Kamata, Takatsugu; Khan, Arif Ullah; Takeuchi, Yoshinori; Imai, Masaharu; Yagi, Tetsuya

    2015-08-01

    Understanding neural responses to multi-site electrical stimuli would be of essential importance for developing cortical neural prostheses. In order to provide a tool for such studies in experimental animals, we recently constructed a prototype of a wireless multi-channel microstimulation system, consisting of a stimulator chip, wireless data/power transmitters and receivers, and microcomputers. The proper operations of the system in cortical neural excitations were examined in anesthetized rats in vivo, with utilizing the voltage-sensitive dye imaging technique.

  17. Remote, PCM-controlled, multi-channel radio frequency FM telemetry system for cryogenic wind tunnel application

    NASA Technical Reports Server (NTRS)

    Diamond, John K.

    1989-01-01

    A telemetry system used in the NASA-Langley cryogenic transonic wind tunnel to obtain rotational strain and temperature data is described. The system consists of four FM transmitters allowing for a remotely controlled PCM combination. A rotating four-contact mercury slip-ring is used as an interface between the fixed and rotating mechnical structures. Over 60 channels of data on the main fan disk and blade structures have been obtained. These data are studied to verify computer predictions and mechanical life. A series of block diagrams are included.

  18. A Substrate-Fusion Protein Is Trapped inside the Type III Secretion System Channel in Shigella flexneri

    PubMed Central

    Dohlich, Kim; Zumsteg, Anna Brotcke; Goosmann, Christian; Kolbe, Michael

    2014-01-01

    The Type III Secretion System (T3SS) is a macromolecular complex used by Gram-negative bacteria to secrete effector proteins from the cytoplasm across the bacterial envelope in a single step. For many pathogens, the T3SS is an essential virulence factor that enables the bacteria to interact with and manipulate their respective host. A characteristic structural feature of the T3SS is the needle complex (NC). The NC resembles a syringe with a basal body spanning both bacterial membranes and a long needle-like structure that protrudes from the bacterium. Based on the paradigm of a syringe-like mechanism, it is generally assumed that effectors and translocators are unfolded and secreted from the bacterial cytoplasm through the basal body and needle channel. Despite extensive research on T3SS, this hypothesis lacks experimental evidence and the mechanism of secretion is not fully understood. In order to elucidate details of the T3SS secretion mechanism, we generated fusion proteins consisting of a T3SS substrate and a bulky protein containing a knotted motif. Because the knot cannot be unfolded, these fusions are accepted as T3SS substrates but remain inside the NC channel and obstruct the T3SS. To our knowledge, this is the first time substrate fusions have been visualized together with isolated NCs and we demonstrate that substrate proteins are secreted directly through the channel with their N-terminus first. The channel physically encloses the fusion protein and shields it from a protease and chemical modifications. Our results corroborate an elementary understanding of how the T3SS works and provide a powerful tool for in situ-structural investigations in the future. This approach might also be applicable to other protein secretion systems that require unfolding of their substrates prior to secretion. PMID:24453973

  19. Design and Simulation of a Matching System into the Helical Cooling Channel

    SciTech Connect

    Yoshikawa, C.; Ankenbrandt, C.; Johnson, R. P.; Kahn, S.; Marhauser, F.; Derbenev, Y.; Morozov, V.; Sy, A.; Alexahin, Y.; Neuffer, D.; Yonehara, K.

    2014-07-01

    Muon colliders could provide the most sensitive measurement of the Higgs mass and return the US back to the Energy Frontier. Central to the capabilities of muon colliders are the cooling channels that provide the extraordinary reduction in emittance required for the precise Higgs mass measurement and increased luminosity for enhanced discovery potential of an Energy Frontier Machine. The Helical Cooling Channel (HCC) is able to achieve such emittance reduction and matching sections within the HCC have been successfully designed in the past with lossless transmission and no emittance growth. However, matching into the HCC from a straight solenoid poses a challenge, since a large emittance beam must cross transition. We elucidate on the challenge and present evaluations of two solutions, along with concepts to integrate the operations of a Charge Separator and match into the HCC.

  20. Symmetrization for redundant channels

    NASA Technical Reports Server (NTRS)

    Tulplue, Bhalchandra R. (Inventor); Collins, Robert E. (Inventor)

    1988-01-01

    A plurality of redundant channels in a system each contain a global image of all the configuration data bases in each of the channels in the system. Each global image is updated periodically from each of the other channels via cross channel data links. The global images of the local configuration data bases in each channel are separately symmetrized using a voting process to generate a system signal configuration data base which is not written into by any other routine and is available for indicating the status of the system within each channel. Equalization may be imposed on a suspect signal and a number of chances for that signal to heal itself are provided before excluding it from future votes. Reconfiguration is accomplished upon detecting a channel which is deemed invalid. A reset function is provided which permits an externally generated reset signal to permit a previously excluded channel to be reincluded within the system. The updating of global images and/or the symmetrization process may be accomplished at substantially the same time within a synchronized time frame common to all channels.

  1. Scalable time-correlated photon counting system with multiple independent input channels.

    PubMed

    Wahl, Michael; Rahn, Hans-Jürgen; Röhlicke, Tino; Kell, Gerald; Nettels, Daniel; Hillger, Frank; Schuler, Ben; Erdmann, Rainer

    2008-12-01

    Time-correlated single photon counting continues to gain importance in a wide range of applications. Most prominently, it is used for time-resolved fluorescence measurements with sensitivity down to the single molecule level. While the primary goal of the method used to be the determination of fluorescence lifetimes upon optical excitation by short light pulses, recent modifications and refinements of instrumentation and methodology allow for the recovery of much more information from the detected photons, and enable entirely new applications. This is achieved most successfully by continuously recording individually detected photons with their arrival time and detection channel information (time tagging), thus avoiding premature data reduction and concomitant loss of information. An important property of the instrumentation used is the number of detection channels and the way they interrelate. Here we present a new instrument architecture that allows scalability in terms of the number of input channels while all channels are synchronized to picoseconds of relative timing and yet operate independent of each other. This is achieved by means of a modular design with independent crystal-locked time digitizers and a central processing unit for sorting and processing of the timing data. The modules communicate through high speed serial links supporting the full throughput rate of the time digitizers. Event processing is implemented in programmable logic, permitting classical histogramming, as well as time tagging of individual photons and their temporally ordered streaming to the host computer. Based on the time-ordered event data, any algorithms and methods for the analysis of fluorescence dynamics can be implemented not only in postprocessing but also in real time. Results from recently emerging single molecule applications are presented to demonstrate the capabilities of the instrument.

  2. A 96 channel receiver for the ILCTA LLRF system at Fermilab

    SciTech Connect

    Mavric, Uros; Chase, Brian; Branlard, Julien; Cullerton, Ed; Klepec, Dan; /Fermilab

    2007-06-01

    The present configuration of an ILC main LINAC RF station has 26 nine cell cavities driven from one klystron. With the addition of waveguide power coupler monitors, 96 RF signals will be down-converted and processed. A down-converter chassis is being developed that contains 12 eight channel analog modules and a single upconverter module. This chassis will first be deployed for testing a cryomodule composed of eight cavities located at New Muon Laboratory (NML) - Fermilab. Critical parts of the design for LLRF applications are identified and a detailed description of the circuit with various characteristic measurements is presented. The board is composed of an input band-pass filter centered at 1.3GHz, followed by a mixer, which down-converts the cavity probe signal to a proposed 13 MHz intermediate frequency. Cables with 8 channels per connector and good isolation between channels are being used to interconnect each down-converter module with a digital board. As mixers, amplifiers and power splitters are the most sensitive parts for noise, nonlinearities and crosstalk issues, special attention is given to these parts in the design of the LO port multiplication and distribution.

  3. Glia and TRPM2 Channels in Plasticity of Central Nervous System and Alzheimer's Diseases

    PubMed Central

    Wang, Jing; Jackson, Michael F.; Xie, Yu-Feng

    2016-01-01

    Synaptic plasticity refers to the ability of neurons to strengthen or weaken synaptic efficacy in response to activity and is the basis for learning and memory. Glial cells communicate with neurons and in this way contribute in part to plasticity in the CNS and to the pathology of Alzheimer's disease (AD), a neurodegenerative disease in which impaired synaptic plasticity is causally implicated. The transient receptor potential melastatin member 2 (TRPM2) channel is a nonselective Ca2+-permeable channel expressed in both glial cells (microglia and astrocytes) and neurons. Recent studies indicated that TRPM2 regulates synaptic plasticity as well as the activation of glial cells. TRPM2 also modulates oxidative stress and inflammation through interaction with glial cells. As both oxidative stress and inflammation have been implicated in AD pathology, this suggests a possible contribution of TRPM2 to disease processes. Through modulating the homeostasis of glutathione, TRPM2 is involved in the process of aging which is a risk factor of AD. These results potentially point TRPM2 channel to be involved in AD through glial cells. This review summarizes recent advances in studying the contribution of TRPM2 in health and in AD pathology, with a focus on contributions via glia cells. PMID:26942016

  4. Glia and TRPM2 Channels in Plasticity of Central Nervous System and Alzheimer's Diseases.

    PubMed

    Wang, Jing; Jackson, Michael F; Xie, Yu-Feng

    2016-01-01

    Synaptic plasticity refers to the ability of neurons to strengthen or weaken synaptic efficacy in response to activity and is the basis for learning and memory. Glial cells communicate with neurons and in this way contribute in part to plasticity in the CNS and to the pathology of Alzheimer's disease (AD), a neurodegenerative disease in which impaired synaptic plasticity is causally implicated. The transient receptor potential melastatin member 2 (TRPM2) channel is a nonselective Ca(2+)-permeable channel expressed in both glial cells (microglia and astrocytes) and neurons. Recent studies indicated that TRPM2 regulates synaptic plasticity as well as the activation of glial cells. TRPM2 also modulates oxidative stress and inflammation through interaction with glial cells. As both oxidative stress and inflammation have been implicated in AD pathology, this suggests a possible contribution of TRPM2 to disease processes. Through modulating the homeostasis of glutathione, TRPM2 is involved in the process of aging which is a risk factor of AD. These results potentially point TRPM2 channel to be involved in AD through glial cells. This review summarizes recent advances in studying the contribution of TRPM2 in health and in AD pathology, with a focus on contributions via glia cells. PMID:26942016

  5. An experimental study of the concatenated Reed-Solomon/Viterbi channel coding system performance and its impact on space communications

    NASA Technical Reports Server (NTRS)

    Liu, K. Y.; Lee, J. J.

    1981-01-01

    The need for efficient space communication at very low bit error probabilities to the specification and implementation of a concatenated coding system using an interleaved Reed-Solomon code as the outer code and a Viterbi-decoded convolutional code as the inner code. Experimental results of this channel coding system are presented under an emulated S-band uplink and X-band downlink two-way space communication channel, where both uplink and downlink have strong carrier power. This work was performed under the NASA End-to-End Data Systems program at JPL. Test results verify that at a bit error probability of 10 to the -6 power or less, this concatenated coding system does provide a coding gain of 2.5 dB or more over the Viterbi-decoded convolutional-only coding system. These tests also show that a desirable interleaving depth for the Reed-Solomon outer code is 8 or more. The impact of this "virtually" error-free space communication link on the transmission of images is discussed and examples of simulation results are given.

  6. Numerical characterization and modeling of subject-specific ultrawideband body-centric radio channels and systems for healthcare applications.

    PubMed

    Abbasi, Qammer Hussain; Sani, Andrea; Alomainy, Akram; Hao, Yang

    2012-03-01

    The paper presents a subject-specific radio propagation study and system modeling in wireless body area networks using a simulation tool based on the parallel finite-difference time-domain technique. This technique is well suited to model the radio propagation around complex, inhomogeneous objects such as the human body. The impact of different digital phantoms in on-body radio channel and system performance was studied. Simulations were performed at the frequency of 3-10 GHz considering a typical hospital environment, and were validated by on-site measurements with reasonably good agreement. The analysis demonstrated that the characteristics of the on-body radio channel and system performance are subject-specific and are associated with human genders, height, and body mass index. Maximum variations of almost 18.51% are observed in path loss exponent due to change of subject, which gives variations of above 50% in system bit error rate performance. Therefore, careful consideration of subject-specific parameters are necessary for achieving energy efficient and reliable radio links and system performance for body-centric wireless network.

  7. A decision support system for real-time management of dissolvedoxygen in the Stockton deep water ship channel

    SciTech Connect

    Quinn, N.W.T.; Chen, Carl W.; Stringfellow, William T.

    2003-07-16

    A decision support system(DSS)is under development to assistin the control and management of episodes of dissolved oxygen sag in aDeep Water Ship Channel (DWSC), located in Stockton, California. The DWSCwas formed by excavating the bed of the San Joaquin River in the 1950'sto allow navigation by ocean-going cargo ships to the Port of Stockton.The deepened channel has the effect of increasing hydraulic residencetime by a factor of ten. allowing accumulation of decaying algae andother oxygen demanding substances - which creates a barrier to themigration of anadromous fish. This problem, which manifests itself inlate summer and early autumn, is an impediment to a multimillion dollarhabitat restoration effort for the salmon fishery in the San JoaquinRiver basin (SJRB). A hydrodynamic and water quality model of the Deltaand San Joaquin River forms the basis of the DSS which will provideforecasts of dissolved oxygen sag in the DWSC and provide modelingsupport for management actions such as forced aeration to improvedissolved oxygen concentrations in the Ship Channel. A graphical userinterlace, currently used for displaying flow and salinity forecasts onthe San Joaquin River, is being adapted to allow the display of dissolvedoxygen forecasts and to encourage the formation of a stakeholder-ledentity or institution to adaptively manage the problem.

  8. Generating double emulsions W/O/W in a PDMS system by controlling locally the wetting properties of the channel

    NASA Astrophysics Data System (ADS)

    Willaime, Herve; Pannacci, Nicolas; Grasland-Mongrain, Pol; Soares, Emilie-Marie; Benzaquen, Michael; Tabeling, Patrick

    2008-11-01

    In microfluidic systems, it has been shown that wetting properties of the wall of the microchannel are of crucial importance for the generation of emulsions [1]: to generate an emulsion in a fluid, the continuous phase must wet the walls of the channel better than the dispersed phase. In the particular case of alternate double emulsions (water in oil in water), it is necessary to pattern the wetting properties of the channel. In this paper, we present preliminary works on the control of wetting properties on PDMS microchannels for the generation of double emulsion. The method we have chosen is inspired by the works of Allbritton [2] and Kumacheva [3] by UV-grafting a hydrophilic polymer onto the surface inside the microchannel. Once the channels are grafted, it is possible to obtain alternate double emulsions. We will present the objects obtained with such microchannels and will focus on their structures and on their stabilities. [1]^ Dreyfus R., Tabeling P., Willaime H., Physical Review Letters, 2003, 90(14). [2] Hu S., Ren X., Bachman M., Sims C., Li G.P., Allbritton N. Anal. Chem. 2004, 76, 1865-1870 [3] Seo M., Paquet C., Nie Z., Xua S., Kumacheva E. Soft Matter, 2007, 3, 986--992

  9. Depositional architecture and evolution of the Late Miocene slope channel-fan-system in the northeastern shelf-margin of South China Sea

    NASA Astrophysics Data System (ADS)

    Jiang, Jing; Lin, Changsong; Zhang, Zhongtao; Tian, Hongxun; Tao, Ze; Liu, Hanyao

    2016-04-01

    The Upper Miocene in the Pearl River Mouth Basin of northwestern shelf-margin of South China Sea Basin contains a series of slope channel - fan systems. Their depositional architecture and evolution are documented in this investigation based on an integrated analysis of cores, logs, and seismic data. Four depositional-palaeogeomorphological elements have been identified in the slope channel-fan systems as follows: broad, shallow and unconfined or partly confined outer-shelf to shelf-break channels; deeply incised and confined unidirectionally migrating slope channels; broad or U-shaped, unconfined erosional-depositional channels; frontal splays-lobes and nonchannelized sheets. The slope channels are mostly oriented NW-SE, which migrated unidirectionally northeastwards and intensively eroded almost the whole shelf-slope zone. The channel infillings are mainly mudstones, interbedded with siltstones. They might be formed by gravity flow erosion as bypassing channels. They were filled with limited gravity flow sediments at the base and mostly filled with lateral accretionary packages of bottom current deposits. At the end of the channels, a series of small-scale slope fans developed and coalesced into fan aprons along the base of the slope. The unconfined erosional-depositional channels at the upper parts of the fan-apron-systems display compound infill patterns, and commonly have concave erosional bases and convex tops. The frontal splays-lobes representing middle to distal deposits of fan-apron-systems have flat-mounded or gull-wing geometries, and the internal architectures include bidirectional downlap, progradation, and chaotic infillings. The distal nonchannelized turbidite sheets are characterized by thin-bedded, parallel to sub-parallel sheet-like geometries. Three major unconformities or obvious erosional surfaces in the channel-fan systems of the Upper Miocene are recognized, and indicate the falling of sea-level. The depositional architecture of sequences

  10. Experimental Investigation and Flow Process Computer Simulation of the Single Mini Channel Condenser for Vapor Compression Refrigeration System

    NASA Astrophysics Data System (ADS)

    Pabilona, L. L.; Villanueva, E. P.

    2015-09-01

    This study is a computer simulation of the temperature profiles and experimental investigation of three 100 mm x 50 mm x 18 mm single mini channel condensers with hydraulic diameters of 3 mm, 2 mm, and 1mm. The mini channels which were made of copper were designed, fabricated and tested. Each unit was connected in a vapor compression cycle with R-134a as the refrigerant. The average refrigerant mass flow rates were varied from 1.296 - 69.471 g/s, and the average inlet and outlet condenser pressure variations were 102.5 - 121.8 kPa and 101.74 -121.23 kPa, respectively. Each condenser was placed inside a mini wind tunnel system where forced draft air was introduced to initiate convective heat transfer. Each condenser was tested and data were gathered every five minute interval for one hour using a Lab View Software. Computer simulations on the flow process were conducted using Solid Works software. The experimental results presented the inlet and outlet condenser pressures, and pressure drops. The experimental heat transfer coefficients were calculated at different mass fluxes during condensation. The values ranged from 3900 to 5200 W/m2-°K for the 3 mm, 2600 to 9000 W/m2-°K for the 2 mm, and 13 to 98 W/m2-°K for the 1 mm. The heat transfer coefficients calculated from experiments were then compared with the computed values using the correlations developed by Dittus-Boelter and Lee-Son. The results showed increasing deviation as the diameter decreased. The discrepancies could be attributed to the appropriateness of the Dittus-Boelter and Lee-Son correlations in small diameter channels, complexities in the flow process which involved two phase flow heat transfer in very small tubes, and the difficulties in attaining very accurate measurements in small channels.

  11. Lithologic and hydrologic controls of mixed alluvial-bedrock channels in flood-prone fluvial systems: bankfull and macrochannels in the Llano River watershed, central Texas, USA

    USGS Publications Warehouse

    Heitmuller, Frank T.; Hudson, Paul F.; Asquith, William H.

    2015-01-01

    The rural and unregulated Llano River watershed located in central Texas, USA, has a highly variable flow regime and a wide range of instantaneous peak flows. Abrupt transitions in surface lithology exist along the main-stem channel course. Both of these characteristics afford an opportunity to examine hydrologic, lithologic, and sedimentary controls on downstream changes in channel morphology. Field surveys of channel topography and boundary composition are coupled with sediment analyses, hydraulic computations, flood-frequency analyses, and geographic information system mapping to discern controls on channel geometry (profile, pattern, and shape) and dimensions along the mixed alluvial-bedrock Llano River and key tributaries. Four categories of channel classification in a downstream direction include: (i) uppermost ephemeral reaches, (ii) straight or sinuous gravel-bed channels in Cretaceous carbonate sedimentary zones, (iii) straight or sinuous gravel-bed or bedrock channels in Paleozoic sedimentary zones, and (iv) straight, braided, or multithread mixed alluvial–bedrock channels with sandy beds in Precambrian igneous and metamorphic zones. Principal findings include: (i) a nearly linear channel profile attributed to resistant bedrock incision checkpoints; (ii) statistically significant correlations of both alluvial sinuosity and valley confinement to relatively high f (mean depth) hydraulic geometry values; (iii) relatively high b (width) hydraulic geometry values in partly confined settings with sinuous channels upstream from a prominent incision checkpoint; (iv) different functional flow categories including frequently occurring events (< 1.5-year return periods) that mobilize channel-bed material and less frequent events that determine bankfull channel (1.5- to 3-year return periods) and macrochannel (10- to 40-year return periods) dimensions; (v) macrochannels with high f values (most ≤ 0.45) that develop at sites with unit stream power values in excess

  12. Performance analysis of short-range NLOS UV communication system using Monte Carlo simulation based on measured channel parameters.

    PubMed

    Luo, Pengfei; Zhang, Min; Han, Dahai; Li, Qing

    2012-10-01

    The research presented in this paper is a performance study of short-range NLOS ultraviolet (UV) communication system, using a Monte-Carlo-based system-level model, in which the channel parameters, such as the path loss and the background noise are experimentally measured using an outdoor UV communication test-bed. Various transceiver geometry and background noise condition are considered. Furthermore, 4 modulation schemes are compared, which provides an insight into the performance prediction and the system trade-offs among the path loss, the optical power, the distance, the link geometry, the bit rate and the bit error rate. Finally, advices are given on UV system design and performance improvement.

  13. Deep-sea channel/submarine-yazoo system of the Labrador Sea: A new deep-water facies model

    SciTech Connect

    Hesse, R.; Rakofsky, A. )

    1992-05-01

    The deep-sea channel/submarine-yazoo system is a newly recognized deep-water depositional environment that is significantly different from previously documented turbidite environments. The new system is in many ways the antithesis of classical deep-sea fans. The purpose of this paper is to present the characteristics and elements of the system, develop a facies model for it, establish the system variables, and discuss its possible significance in the geologic record and in subsurface exploration. Previous investigators of deepwater turbidite sediments often faced difficulties in trying to fit their sequences into traditional single-source, deep-sea fan models. The present model fills part of an obvious gap in interpretation schemes for deep-water clastic sediments.

  14. Generalized channeled polarimetry.

    PubMed

    Alenin, Andrey S; Tyo, J Scott

    2014-05-01

    Channeled polarimeters measure polarization by modulating the measured intensity in order to create polarization-dependent channels that can be demodulated to reveal the desired polarization information. A number of channeled systems have been described in the past, but their proposed designs often unintentionally sacrifice optimality for ease of algebraic reconstruction. To obtain more optimal systems, a generalized treatment of channeled polarimeters is required. This paper describes methods that enable handling of multi-domain modulations and reconstruction of polarization information using linear algebra. We make practical choices regarding use of either Fourier or direct channels to make these methods more immediately useful. Employing the introduced concepts to optimize existing systems often results in superficial system changes, like changing the order, orientation, thickness, or spacing of polarization elements. For the two examples we consider, we were able to reduce noise in the reconstruction to 34.1% and 57.9% of the original design values. PMID:24979633

  15. Analytical modeling of a single channel nonlinear fiber optic system based on QPSK.

    PubMed

    Kumar, Shiva; Shahi, Sina Naderi; Yang, Dong

    2012-12-01

    A first order perturbation theory is used to develop analytical expressions for the power spectral density (PSD) of the nonlinear distortions due to intra-channel four-wave mixing (IFWM). For non-Gaussian pulses, the PSD can not be calculated analytically. However, using the stationary phase approximations, we found that convolutions become simple multiplications and a simple analytical expression for the PSD of the nonlinear distortion is found. The PSD of the nonlinear distortion is combined with the amplified spontaneous emission (ASE) PSD to obtain the total variance and bit error ratio (BER). The analytically estimated BER is found to be in good agreement with numerical simulations.

  16. The Kongsfjorden Channel System offshore NW Spitsbergen, European Arctic: evidence of down-slope processes in a contour-current dominated setting on the continental margin

    NASA Astrophysics Data System (ADS)

    Forwick, Matthias; Sverre Laberg, Jan; Hass, H. Christian; Osti, Giacomo

    2016-04-01

    The Kongsfjorden Channel System (KCS) is located on the continental slope in the eastern Fram Strait, off northwest Spitsbergen. It provides evidence that the influence of down-slope sedimentary processes locally exceeds regional along-slope sedimentation. Compared to other submarine channel systems on and off glaciated continental margins, it is a relatively short system (~120 km) occurring at a large range of water depths (~250-4000 m). It originates with multiple gullies on the Kongsfjorden Trough Mouth Fan merging to small channels that further downslope merge to a main channel. The overall location of the channel system is controlled by variations in slope gradients (0-20°) and the ambient regional bathymetry: widest and deepest incisions occur in areas of steepest slope gradients. The KCS has probably been active since ~1 Ma when glacial activity on Svalbard increased and grounded ice expanded to the shelf break off Kongsfjorden repeatedly. Activity within the system was probably highest during glacials. However, reduced activity presumably took place also during interglacials. The presentation summarizes the work of Forwick et al. (2015). Reference: Forwick, M., Laberg, J.S., Hass, H.C. & Osti, C., 2015. The Kongsfjorden Channel System offshore NW Svalbard: downslope sedimentary processes in a contour-current-dominated setting. Arktos 1, DOI: 10.1007/s41063-015-0018-4.

  17. Long-term high frequency phytoplankton dynamics, recorded from a coastal water autonomous measurement system in the eastern English Channel

    NASA Astrophysics Data System (ADS)

    Derot, J.; Schmitt, F. G.; Gentilhomme, V.; Zongo, S. B.

    2015-10-01

    In this paper, high frequency fluorescence fluctuations, recorded from 2004 to 2011 using an autonomous underwater monitoring system in the eastern English Channel, at 20-min time resolutions, are analyzed. Annual blooms are superposed to multiscale fluctuations. The probability density function (pdf) of the fluorescence time series obeys a power law with slope -2. The pdf for annual portions also obeys power laws, with slopes related to the annual average. Empirical mode decomposition (EMD) is used to study the dynamics and display the power spectrum, which is different from the temperature power spectrum. EMD is also used to extract a trend and isolate the blooms from the high frequency dynamics.

  18. Catastrophic flooding origin of shelf valley systems in the English Channel.

    PubMed

    Gupta, Sanjeev; Collier, Jenny S; Palmer-Felgate, Andy; Potter, Graeme

    2007-07-19

    Megaflood events involving sudden discharges of exceptionally large volumes of water are rare, but can significantly affect landscape evolution, continental-scale drainage patterns and climate change. It has been proposed that a significant flood event eroded a network of large ancient valleys on the floor of the English Channel-the narrow seaway between England and France. This hypothesis has remained untested through lack of direct evidence, and alternative non-catastrophist ideas have been entertained for valley formation. Here we analyse a new regional bathymetric map of part of the English Channel derived from high-resolution sonar data, which shows the morphology of the valley in unprecedented detail. We observe a large bedrock-floored valley that contains a distinct assemblage of landforms, including streamlined islands and longitudinal erosional grooves, which are indicative of large-scale subaerial erosion by high-magnitude water discharges. Our observations support the megaflood model, in which breaching of a rock dam at the Dover Strait instigated catastrophic drainage of a large pro-glacial lake in the southern North Sea basin. We suggest that megaflooding provides an explanation for the permanent isolation of Britain from mainland Europe during interglacial high-sea-level stands, and consequently for patterns of early human colonisation of Britain together with the large-scale reorganization of palaeodrainage in northwest Europe. PMID:17637667

  19. Catastrophic flooding origin of shelf valley systems in the English Channel.

    PubMed

    Gupta, Sanjeev; Collier, Jenny S; Palmer-Felgate, Andy; Potter, Graeme

    2007-07-19

    Megaflood events involving sudden discharges of exceptionally large volumes of water are rare, but can significantly affect landscape evolution, continental-scale drainage patterns and climate change. It has been proposed that a significant flood event eroded a network of large ancient valleys on the floor of the English Channel-the narrow seaway between England and France. This hypothesis has remained untested through lack of direct evidence, and alternative non-catastrophist ideas have been entertained for valley formation. Here we analyse a new regional bathymetric map of part of the English Channel derived from high-resolution sonar data, which shows the morphology of the valley in unprecedented detail. We observe a large bedrock-floored valley that contains a distinct assemblage of landforms, including streamlined islands and longitudinal erosional grooves, which are indicative of large-scale subaerial erosion by high-magnitude water discharges. Our observations support the megaflood model, in which breaching of a rock dam at the Dover Strait instigated catastrophic drainage of a large pro-glacial lake in the southern North Sea basin. We suggest that megaflooding provides an explanation for the permanent isolation of Britain from mainland Europe during interglacial high-sea-level stands, and consequently for patterns of early human colonisation of Britain together with the large-scale reorganization of palaeodrainage in northwest Europe.

  20. Dissection of the peripheral motion channel in the visual system of Drosophila melanogaster.

    PubMed

    Rister, Jens; Pauls, Dennis; Schnell, Bettina; Ting, Chun-Yuan; Lee, Chi-Hon; Sinakevitch, Irina; Morante, Javier; Strausfeld, Nicholas J; Ito, Kei; Heisenberg, Martin

    2007-10-01

    In the eye, visual information is segregated into modalities such as color and motion, these being transferred to the central brain through separate channels. Here, we genetically dissect the achromatic motion channel in the fly Drosophila melanogaster at the level of the first relay station in the brain, the lamina, where it is split into four parallel pathways (L1-L3, amc/T1). The functional relevance of this divergence is little understood. We now show that the two most prominent pathways, L1 and L2, together are necessary and largely sufficient for motion-dependent behavior. At high pattern contrast, the two pathways are redundant. At intermediate contrast, they mediate motion stimuli of opposite polarity, L2 front-to-back, L1 back-to-front motion. At low contrast, L1 and L2 depend upon each other for motion processing. Of the two minor pathways, amc/T1 specifically enhances the L1 pathway at intermediate contrast. L3 appears not to contribute to motion but to orientation behavior. PMID:17920022

  1. A Bed Load Monitoring System for Real Time Sediment Transport and Bed Morphology during Channel Altering Events

    NASA Astrophysics Data System (ADS)

    Curran, J. C.; Waters, K. A.; Cannatelli, K.

    2014-12-01

    A new technique is presented that provides continuous measurement of sediment movement over the length of a flume. Real-time measurements of bed changes over a reach are a missing piece needed to link bed morphology with sediment transport processes during unsteady flows when the bed adjusts quickly to changing transport rates or visual observation of the bed is precluded by fine sediment in the water column. A bed load monitoring system (BLMS) was developed that records the sediment and water loads over discrete bed lengths throughout a flow event. It was designed for laboratory application where controlled measurement methods are possible. Upon data processing, the BLMS provides a continuous measure of the sediment load across the bed from which sediment movement rates through the reach, including areas of temporary aggradation or degradation, can be reconstructed. Examples are provided of how the bed load monitoring system has been applied during sediment feed and sediment recirculation experiments to further the interpretation of channel processes occurring during large flows. We detail the use of the BLMS to measure bed slopes during unsteady flows and to measure the movement of sediment downstream following different methods of dam removal. We evaluate the BLMS for use where DEM differencing was also applied to illustrate the information provided by each measurement method. Exciting implications of future research that incorporates a BLMS include a more informed management of river systems as a result of improved temporal predictions of sediment movement and the associated changes in channel slope and morphology.

  2. Measurements and coupled reaction channels analysis of one- and two-proton transfer reactions for the 28Si + 90,94Zr systems

    NASA Astrophysics Data System (ADS)

    Kalkal, Sunil; Mandal, S.; Jhingan, A.; Gehlot, J.; Sugathan, P.; Golda, K. S.; Madhavan, N.; Garg, Ritika; Goyal, Savi; Mohanto, Gayatri; Sandal, Rohit; Chakraborty, Santosh; Verma, Shashi; Behera, Bivash; Eleonora, G.; Wollersheim, H. J.; Singh, R.

    2012-03-01

    Measurements of angular distributions for one- and two-proton stripping reactions for 28Si + 90,94Zr systems were performed at 120 MeV. The experiment was carried out with the 28Si beam at Inter University Accelerator Center, New Delhi. The theoretical calculations were performed using the quantum mechanical coupled reaction channels code fresco. The distorted wave Born approximation calculations reproduced the experimental angular distributions for the one-proton transfer channel for both the systems reasonably well but failed for the two-proton transfer channel. Coupled channels calculations including various intermediate states (involving target and projectile inelastic excitations before and/or after transfer) along with the sequential transfer were able to reproduce the two-proton transfer angular distributions for both the systems reasonably well. It seems that at an energy above the Coulomb barrier, there is significant contribution of the indirect multistep and sequential transfer to the two-proton stripping reaction.

  3. Morphostructure and controlling factors on the past and present Gioia-Mesima submarine/channel system (Southern Tyrrhenian Sea, Italy)

    NASA Astrophysics Data System (ADS)

    Morelli, Eleonora; Martorelli, Eleonora; Latino Chiocci, Francesco

    2013-04-01

    The Gioia-Mesima Canyon-Channel System (GMS) incises the Gioia Basin, a post-Tortonian intra-slope basin extended along the south-eastern Tyrrhenian margin, consisting in a subsiding area controlled by extensional faults. Integration of multibeam, side scan sonar and seismic data with gravity cores has revealed the morpho-stratigraphic and sedimentologic characteristics of the GMS, allowing the identification of the main factors controlling its development and maintenance. The GMS displays a complex morphology consisting in two courses: the Gioia Canyon (GC) and Mesima Canyon-Channel (MC). The courses running parallel, changing from narrow to meandering geometry until they merge in a single lower reach, hanging above the Stromboli Canyon- the main erosive valley of the Gioia Basin. Seismic profiles documented the strong tectonic control on GMS geometry and development. Distensional structures cross-cutting the GMS caused changes in the slope gradient and formed a small intra-slope sub-basin. The progressive infilling of the sub-basin caused changes in GMS base level position, determining a polyphased evolution of the GMS through repeated erosional and depositional events that can be divided in two main stages. The early stage is concurrent with the progressive infilling of the sub-basin. At this time the Gioia and Mesima courses have the same characteristics: narrow erosive canyons along the upper slope and depositional meandering channels in the sub-basin, where the GMS is confined. The GMS erosive-depositional character is revealed by the acoustic facies distribution. The narrow canyons incise a stratified seismic facies (hemipelagic and turbidite deposits) while the meandering channels are confined in a channel-levee seismic facies aggrading over the stratified one. The presence of numerous terraces hanging at several levels above the lower meandering reaches proves the polyphased evolution of the depositional meandering channels. In the later stage, when the

  4. Modified Fletcher's 3-channel brachytherapy system with vaginal line source loading versus uterine tandem and vaginal cylinder system in Stage IIIA cervical cancer

    PubMed Central

    Low, JSH; Ng, KB

    2006-01-01

    Purpose The uterine tandem with open-ended vaginal cylinder is the most commonly used brachytherapy system for Federation Internationale de Gynecologie et d'Obstetrique (FIGO) Stage IIIA cervix cancer at the National Cancer Centre, Singapore. Without the 3-channel ovoid system, the dose to the parametrium is often compromised. In this study, a vaginal cylinder that could potentially be incorporated with the 3-channel system was developed, hence addressing the problem of treating both the vaginal disease extension and the parametrium. Methods and materials A hollow cylinder of 3 cm in diameter was incorporated with the Fletcher's 3-channel tandem and ovoid system. Treatment plans were generated with the single tandem line source with a vaginal cylinder applicator and the modified Fletcher's system using the Abacus version 3 brachytherapy treatment planning software. A nominal dose of 5 Gy was prescribed to point H for both plans. The perpendicular distance of the 5 Gy isodose line from the uterine tandem plane at the centre of the ovoid and the vaginal cylinder plane 1 cm below the os guard were then compared. Results The 5 Gy isodose line was 1.7 cm from the uterine tandem source at the location lateral through the centre of the ovoids on the plan with the uterine tandem and vaginal cylinder system as compared to a distance of 3.3 cm using the modified 3-channel Fletcher system. The 5 Gy isodose line was 2 cm lateral to the central source at the vaginal cylinder plane 1 cm below the os guard on the uterine tandem and vaginal cylinder system as compared to a distance of 2.5 cm on the Modified-Fletcher system. This corresponds to an increase of 1.6 cm and 0.5 cm depth of treated parametrium on the uterine tandem plane and vaginal cylinder plane respectively with the modified Fletcher's applicator as compared with the single line source cylinder system. Conclusion As compared with the single uterine tandem and open-ended vaginal cylinder system, an addition of 1.6 cm

  5. Transient and big are key features of an invertebrate T-type channel (LCav3) from the central nervous system of Lymnaea stagnalis.

    PubMed

    Senatore, Adriano; Spafford, J David

    2010-03-01

    Here we describe features of the first non-mammalian T-type calcium channel (LCa(v)3) expressed in vitro. This molluscan channel possesses combined biophysical properties that are reminiscent of all mammalian T-type channels. It exhibits T-type features such as "transient" kinetics, but the "tiny" label, usually associated with Ba(2+) conductance, is hard to reconcile with the "bigness" of this channel in many respects. LCa(v)3 is 25% larger than any voltage-gated ion channel expressed to date. It codes for a massive, 322-kDa protein that conducts large macroscopic currents in vitro. LCa(v)3 is also the most abundant Ca(2+) channel transcript in the snail nervous system. A window current at typical resting potentials appears to be at least as large as that reported for mammalian channels. This distant gene provides a unique perspective to analyze the structural, functional, drug binding, and evolutionary aspects of T-type channels. PMID:20056611

  6. Fading channel simulator

    DOEpatents

    Argo, Paul E.; Fitzgerald, T. Joseph

    1993-01-01

    Fading channel effects on a transmitted communication signal are simulated with both frequency and time variations using a channel scattering function to affect the transmitted signal. A conventional channel scattering function is converted to a series of channel realizations by multiplying the square root of the channel scattering function by a complex number of which the real and imaginary parts are each independent variables. The two-dimensional inverse-FFT of this complex-valued channel realization yields a matrix of channel coefficients that provide a complete frequency-time description of the channel. The transmitted radio signal is segmented to provide a series of transmitted signal and each segment is subject to FFT to generate a series of signal coefficient matrices. The channel coefficient matrices and signal coefficient matrices are then multiplied and subjected to inverse-FFT to output a signal representing the received affected radio signal. A variety of channel scattering functions can be used to characterize the response of a transmitter-receiver system to such atmospheric effects.

  7. Analysis of effective capacity for free-space optical communication systems over gamma-gamma turbulence channels with pointing errors

    NASA Astrophysics Data System (ADS)

    Yang, You-quan; Chi, Xue-fen; Shi, Jia-lin; Zhao, Lin-lin

    2015-05-01

    To facilitate the efficient support of quality-of-service (QoS) for promising free-space optical (FSO) communication systems, it is essential to model and analyze FSO channels in terms of delay QoS. However, most existing works focus on the average capacity and outage capacity for FSO, which are not enough to characterize the effective transmission data rate when delay-sensitive service is applied. In this paper, the effective capacity of FSO communication systems under statistical QoS provisioning constraints is investigated to meet heterogeneous traffic demands. A novel closed-form expression for effective capacity is derived under the combined effects of atmospheric turbulence conditions, pointing errors, beam widths, detector sizes and QoS exponents. The obtained results reveal the effects of some significant parameters on effective capacity, which can be used for the design of FSO systems carrying a wide range of services with diverse QoS requirements.

  8. A frequency tunable, eight-channel correlation ECE system for electron temperature turbulence measurements on the DIII-D tokamak

    NASA Astrophysics Data System (ADS)

    Sung, C.; Peebles, W. A.; Wannberg, C.; Rhodes, T. L.; Nguyen, X.; Lantsov, R.; Bardóczi, L.

    2016-11-01

    A new eight-channel correlation electron cyclotron emission diagnostic has recently been installed on the DIII-D tokamak to study both turbulent and coherent electron temperature fluctuations under various plasma conditions and locations. This unique system is designed to cover a broad range of operation space on DIII-D (1.6-2.1 T, detection frequency: 72-108 GHz) via four remotely selected local oscillators (80, 88, 96, and 104 GHz). Eight radial locations are measured simultaneously in a single discharge covering as much as half the minor radius. In this paper, we present design details of the quasi-optical system, the receiver, as well as representative data illustrating operation of the system.

  9. Jamming in Vertical Channels

    NASA Astrophysics Data System (ADS)

    Baxter, G. William; Steel, Fiona

    2011-03-01

    We study jamming of low aspect-ratio cylindrical Delrin grains in a vertical channel. Grain heights are less than their diameter so the grains resemble antacid tablets, coins, or poker chips. These grains are allowed to fall through a vertical channel with a square cross section where the channel width is greater than the diameter of a grain and constant throughout the length of the channel with no obstructions or constrictions. Grains are sometimes observed to form jams, stable structures supported by the channel walls with no support beneath them. The probability of jam occurrence and the strength or robustness of a jam is effected by grain and channel sizes. We will present experimental measurements of the jamming probability and jam strength in this system and discuss the relationship of these results to other experiments and theories. Supported by an Undergraduate Research Grant from Penn State Erie, The Behrend College.

  10. Aram Dorsum, Candidate ExoMars Rover Landing Site: a Noachian Inverted Fluvial Channel System in Arabia Terra Mars

    NASA Astrophysics Data System (ADS)

    Balme, Matthew; Grindrod, Peter; Sefton-Nash, Elliot; Davis, Joel; Gupta, Sanjeev; Fawdon, Peter

    2016-04-01

    Much of Mars' Noachian-aged southern highlands is dissected by systems of fluvial channels and valleys > 3.7 Ga in age. Arabia Terra, lying between the southern highlands and the northern lowlands, is similarly ancient, yet apparently has few valley networks. This regional lack of valley networks only matches Noachian precipitation predictions from climate models if the Noachian climate was dry and cold [1]. In this scenario, highlands dissection was caused by transient flows of meltwater from large, regionally restricted ice-bodies. However, new results [2,3] show that Arabia Terra is not as poorly dissected as previously thought, and in fact there are extensive networks of inverted channel systems. Here, we describe an example of such a system - Aram Dorsum - which has been studied extensively as an ExoMars Rover candidate landing site. Aram Dorsum is an ~100 km long, 1-2 km wide, branching, flat-topped ridge system, in western Arabia Terra. We have mapped the system using CTX images, DEMs and other data. We interpret the ridge system to be fluvial in origin, preserved in positive relief due to infill and differential erosion; this working hypothesis is used as a conceptual framework for the study. Aram Dorsum is a branching, multi-level, contributory network, set in surrounding floodplains-like material. This demonstrates that it was a relatively long-lived, aggradational fluvial system, rather than an erosional outflow or bedrock-carved fluvial channel. Interestingly, the system shows little evidence for unconfined lateral channel migration, so there must have been significant bank stability. Aram Dorsum was therefore probably once a sizable river and, as just one example of many similar systems, is an exemplar for the middle part of a regional sediment transport system that could have extended from the southern highlands to the northern lowlands. Like Aram Dorsum, many of these other recently-recognized fluvial systems have an origin more consistent with

  11. Theoretical study of effects of the entrance channel on the relative yield of complete fusion and quasifission in heavy-ion collisions within a dinuclear system approach

    NASA Astrophysics Data System (ADS)

    Soheyli, S.; Khanlari, M. Varasteh

    2016-09-01

    The relative yield of complete fusion and quasifission components for the 12C+204Pb , 19F+197Au , 30Si+186W , and 48Ca+168Er reactions which all lead to the compound nucleus 216Ra are analyzed to calculate the entrance channel effects by comparison of capture, complete fusion, and quasifission cross sections, emission barriers (Bfus*,Bq f ), as well as complete fusion probability estimated by statistical method within the framework of the dinuclear system model. The difference among complete fusion probabilities calculated by the dinuclear system model for different entrance channels can be explained by the hindrance to complete fusion due to the larger inner fusion barrier Bfus* for the transformation of the dinuclear system into a compound nucleus and the increase of the quasifission contribution due to the decreasing of the emission barrier Bq f of quasifission as a function of the angular momentum. Although these reactions with different entrance channels populate the same compound nucleus 216Ra at similar excitation energies, the model predicts the negligible quasifission probability for reactions having higher entrance channel mass asymmetry and the dominant decay channel is complete fission. For reactions induced by massive projectiles such as Si and Ca having lower entrance channel mass asymmetry, the quasifission component is dominant in the evolution of dinuclear system, and the fusion process is extremely hindered.

  12. Development of manufacturing systems for nanocrystalline and ultra-fine grain materials employing indexing equal channel angular pressing

    NASA Astrophysics Data System (ADS)

    Hester, Michael Wayne

    Nanotechnology offers significant opportunities in providing solutions to existing engineering problems as well as breakthroughs in new fields of science and technology. In order to fully realize benefits from such initiatives, nanomanufacturing methods must be developed to integrate enabling constructs into commercial mainstream. Even though significant advances have been made, widespread industrialization in many areas remains limited. Manufacturing methods, therefore, must continually be developed to bridge gaps between nanoscience discovery and commercialization. A promising technology for integration of top-down nanomanufacturing yet to receive full industrialization is equal channel angular pressing, a process transforming metallic materials into nanostructured or ultra-fine grained materials with significantly improved performance characteristics. To bridge the gap between process potential and actual manufacturing output, a prototype top-down nanomanufacturing system identified as indexing equal channel angular pressing (IX-ECAP) was developed. The unit was designed to capitalize on opportunities of transforming spent or scrap engineering elements into key engineering commodities. A manufacturing system was constructed to impose severe plastic deformation via simple shear in an equal channel angular pressing die on 1100 and 4043 aluminum welding rods. 1/4 fraction factorial split-plot experiments assessed significance of five predictors on the response, microhardness, for the 4043 alloy. Predictor variables included temperature, number of passes, pressing speed, back pressure, and vibration. Main effects were studied employing a resolution III design. Multiple linear regression was used for model development. Initial studies were performed using continuous processing followed by contingency designs involving discrete variable length work pieces. IX-ECAP offered a viable solution in severe plastic deformation processing. Discrete variable length work piece

  13. Parallel Multistage Decision Feedback Equalizer for Single-Carrier Layered Space-Time Systems in Frequency-Selective Channels

    NASA Astrophysics Data System (ADS)

    Xu, Jing; Wang, Haifeng; Cheng, Shixin; Chen, Ming

    2004-12-01

    Space-time transmission techniques can greatly increase the spectral efficiency. In this paper, a parallel multistage decision feedback equalizer (PMDFE) is proposed for single-carrier layered space-time systems with a fixed cyclic prefix over frequency-selective channels. It is composed of a parallel interference canceller, a multiple-input single-output decision feedback equalizer (MISO-DFE), and a linear combiner. The soft output of the MISO-DFE is linearly combined with the previous tentative soft decision. In addition, an algorithm is proposed to obtain tentative soft and hard decisions for initializing the equalizer. The initializing complexity of the PMDFE is lower than that of MIMO-OFDM. Simulation results show that the PMDFE outperforms MIMO-OFDM and previously existing equalizers for single-carrier layered space-time systems.

  14. Ancient drainage basin of the Tharsis region, Mars: Potential source for outflow channel systems and putative oceans or paleolakes

    USGS Publications Warehouse

    Dohm, J.M.; Ferris, J.C.; Baker, V.R.; Anderson, R.C.; Hare, T.M.; Strom, R.G.; Barlow, N.G.; Tanaka, K.L.; Klemaszewski, J.E.; Scott, D.H.

    2001-01-01

    Paleotopographic reconstructions based on a synthesis of published geologic information and high-resolution topography, including topographic profiles, reveal the potential existence of an enormous drainage basin/aquifer system in the eastern part of the Tharsis region during the Noachian Period. Large topographic highs formed the margin of the gigantic drainage basin. Subsequently, lavas, sediments, and volatiles partly infilled the basin, resulting in an enormous and productive regional aquifer. The stacked sequences of water-bearing strata were then deformed locally and, in places, exposed by magmatic-driven uplifts, tectonic deformation, and erosion. This basin model provides a potential source of water necessary to carve the large outflow channel systems of the Tharsis and surrounding regions and to contribute to the formation of putative northern-plains ocean(s) and/or paleolakes. Copyright 2001 by the American Geophysical Union.

  15. Athermalized channeled spectropolarimeter enhancement.

    SciTech Connect

    Jones, Julia Craven; Way, Brandyn Michael; Mercier, Jeffrey Alan; Hunt, Jeffery P.

    2013-09-01

    Channeled spectropolarimetry can measure the complete polarization state of light as a function of wavelength. Typically, a channeled spectropolarimeter uses high order retarders made of uniaxial crystal to amplitude modulate the measured spectrum with the spectrally-dependent Stokes polarization information. A primary limitation of conventional channeled spectropolarimeters is related to the thermal variability of the retarders. Thermal variation often forces frequent system recalibration, particularly for field deployed systems. However, implementing thermally stable retarders, made of biaxial crystal, results in an athermal channeled spectropolarimeter that relieves the need for frequent recalibration. This report presents experimental results for an anthermalized channeled spectropolarimeter prototype produced using potassium titanyl phosphate. The results of this prototype are compared to the current thermal stabilization state of the art. Finally, the application of the technique to the thermal infrared is studied, and the athermalization concept is applied to an infrared imaging spectropolarimeter design.

  16. Performance of single and dual-polarized optically preamplified M-ary PPM systems with finite extinction ratios over FSO fading channels

    NASA Astrophysics Data System (ADS)

    Landolsi, Taha; Elrefaie, Aly F.

    2016-05-01

    M-ary pulse position modulation (PPM) systems have been considered in free-space optical (FSO) communications, optical fiber links, and passive optical networks. In this paper, we study the error performance of direct-detection optically preamplified M-ary PPM systems over slowly fading FSO channels. The study considers the combined effects on the probability of bit error, Pb, of channel fading with a given scintillation index, σp2, the transmitter finite extinction ratio, r, and the preamplifier spontaneous emission (ASE) noise. We provide results for both single and dual-polarized systems with symbol sizes M ∈ { 2, 4, …, 1024 } at Pb =10-4 and Pb =10-9. The fading models considered in this study are the exponential, log-normal, and gamma-gamma channels. For single-polarized systems with infinite extinction ratios, we provide closed-form expressions for the bit error probabilities for the three channel models. For the dual-polarized systems we compute them numerically. The results indicate that gamma-gamma fading imposes a more severe penalty than the log-normal case. In this study, the power penalty at Pb =10-9 ranges between 1.8 and 14 dB for the log-normal channel, whereas it ranges between 2.2 and 30.7 dB for the gamma-gamma channel. The study also demonstrates that the power penalty due to the combined effects of transmitter finite r and channel fading is the sum of the penalty due to fading alone and the penalty due to a finite r alone, and that the power penalty for dual-polarized systems is about 0.4 dB larger than single-polarized ones.

  17. Performance improvement of FSO/CDMA systems over dispersive turbulence channel using multi-wavelength PPM signaling.

    PubMed

    Dang, Ngoc T; Pham, Anh T

    2012-11-19

    Previous studies show that, compared to on-off keying (OOK) signaling, pulse-position modulation (PPM) is favorable in FSO/CDMA systems thanks to its energy efficiency and simple detection. Nevertheless, when the system bit rate increases and the transmission distance is far, the FSO/CDMA systems using PPM signaling critically suffer from the impact of pulse broadening caused by dispersion, especially when the modulation level is high. In this paper, we therefore propose to use multi-wavelength PPM (MWPPM) signaling to overcome the limitation of PPM. To further improve the system performance, avalanche photodiode (APD) is also used. The performance of the proposed system is theoretically analyzed using a realistic model of Gaussian pulse propagation. To model the impact of intensity fluctuation caused by the atmospheric turbulence, the log-normal channel is used. We find that, by using MWPPM, the effects of both intensity fluctuation and pulse broadening are mitigated, the BER is therefore significantly improved. Additionally, we quantitatively show that the system performance is further improved by using APD, especially when the average APD gain is chosen properly.

  18. An Inductively Powered Scalable 32-Channel Wireless Neural Recording System-on-a-Chip for Neuroscience Applications

    PubMed Central

    Lee, Seung Bae; Lee, Hyung-Min; Kiani, Mehdi; Jow, Uei-Ming; Ghovanloo, Maysam

    2014-01-01

    We present an inductively powered 32-channel wireless integrated neural recording (WINeR) system-on-a-chip (SoC) to be ultimately used for one or more small freely behaving animals. The inductive powering is intended to relieve the animals from carrying bulky batteries used in other wireless systems, and enables long recording sessions. The WINeR system uses time-division multiplexing along with a novel power scheduling method that reduces the current in unused low-noise amplifiers (LNAs) to cut the total SoC power consumption. In addition, an on-chip high-efficiency active rectifier with optimized coils help improve the overall system power efficiency, which is controlled in a closed loop to supply stable power to the WINeR regardless of the coil displacements. The WINeR SoC has been implemented in a 0.5-µm standard complementary metal–oxide semiconductor process, measuring 4.9 × 3.3 mm2 and consuming 5.85 mW at ± 1.5 V when 12 out of 32 LNAs are active at any time by power scheduling. Measured input-referred noise for the entire system, including the receiver located at 1.2 m, is 4.95 µVrms in the 1 Hz~10 kHz range when the system is inductively powered with 7-cm separation between aligned coils. PMID:23850753

  19. Systemic Administration of the TRPV3 Ion Channel Agonist Carvacrol Induces Hypothermia in Conscious Rodents

    PubMed Central

    Feketa, Viktor V.; Marrelli, Sean P.

    2015-01-01

    Therapeutic hypothermia is a promising new strategy for neuroprotection. However, the methods for safe and effective hypothermia induction in conscious patients are lacking. The current study explored the Transient Receptor Potential Vanilloid 3 (TRPV3) channel activation by the agonist carvacrol as a potential hypothermic strategy. It was found that carvacrol lowers core temperature after intraperitoneal and intravenous administration in mice and rats. However, the hypothermic effect at safe doses was modest, while higher intravenous doses of carvacrol induced a pronounced drop in blood pressure and substantial toxicity. Experiments on the mechanism of the hypothermic effect in mice revealed that it was associated with a decrease in whole-body heat generation, but not with a change in cold-seeking behaviors. In addition, the hypothermic effect was lost at cold ambient temperature. Our findings suggest that although TRPV3 agonism induces hypothermia in rodents, it may have a limited potential as a novel pharmacological method for induction of hypothermia in conscious patients due to suboptimal effectiveness and high toxicity. PMID:26528923

  20. Simulation of supercritical flows in rocket-motor engines: application to cooling channel and injection system

    NASA Astrophysics Data System (ADS)

    Ribert, G.; Taieb, D.; Petit, X.; Lartigue, G.; Domingo, P.

    2013-03-01

    To address physical modeling of supercritical multicomponent fluid flows, ideal-gas law must be changed to real-gas equation of state (EoS), thermodynamic and transport properties have to incorporate dense fluid corrections, and turbulence modeling has to be reconsidered compared to classical approaches. Real-gas thermodynamic is presently investigated with validation by NIST (National Institute of Standards and Technology) data. Two major issues of Liquid Rocket Engines (LRE) are also presented. The first one is the supercritical fluid flow inside small cooling channels. In a context of LRE, a strong heat flux coming from the combustion chamber (locally Φ ≈ 80 MW/m2) may lead to very steep density gradients close to the wall. These gradients have to be thermodynamically and numerically captured to properly reproduce in the simulation the mechanism of heat transfer from the wall to the fluid. This is done with a shock-capturing weighted essentially nonoscillatory (WENO) numerical discretization scheme. The second issue is a supercritical fluid injection following experimental conditions [1] in which a trans- or supercritical nitrogen is injected into warm nitrogen. The two-dimensional results show vortex structures with high fluid density detaching from the main jet and persisting in the low-speed region with low fluid density.

  1. Multi-channel purge and trap system coupled with ion chromatography for the determination of alkylamines in cosmetics.

    PubMed

    Zhong, Zhixiong; Li, Gongke; Luo, Zhibin; Zhu, Binghui

    2012-02-17

    A new multi-channel purge and trap system coupled with ion chromatography for the determination of six alkylamines in cosmetics was developed. The proposed method, based on purge and trap of the volatile alkylamines, involved in a miniaturization and multi-channel integration of classical steam distillation and a simple approach for routine labs. The procedure was rapidly achieved within 10 min and the matrix interferences could be effectively eliminated. Sample pretreatment frequency was higher than 40 h(-1). The linear ranges were 0.1-15 mg L(-1) and the detection limits varied from 0.023 to 0.038 mg L(-1). This method was successfully utilized to determine the amounts of alkylamines in cosmetics with recoveries ranging from 80.3 to 105.5% and the relative standard deviations (RSDs) ranging from 0.78 to 7.5%. It was proved to be accurate, time-saving, and suitable for the determination of large numbers of cosmetics in a short time. PMID:22244166

  2. Singular vectors of a linear imaging system as efficient channels for the ideal observer in detection tasks involving non-Gaussian distributed lumpy images

    NASA Astrophysics Data System (ADS)

    Witten, Joel M.; Park, Subok; Myers, Kyle J.

    2008-03-01

    The Bayesian ideal observer sets an upper bound for diagnostic performance of an imaging system in binary detection tasks. Thus, this observer should be used for image quality assessment whenever possible. However, it is difficult to compute ideal-observer performance because the probability density functions of the data, required for the observer, are often unknown in tasks involving complex backgrounds. Furthermore, the dimension of the integrals that need to be calculated for the observer is huge. To attempt to reduce the dimensionality of the problem, and yet still approximate ideal-observer performance, a channelized-ideal observer (CIO) with Laguerre-Gauss channels was previously investigated for detecting a Gaussian signal at a known location in non-Gaussian lumpy images. While the CIO with Laguerre-Gauss channels had, in some cases, approximated ideal-observer performance, there was still a gap between the mean performance of the ideal observer and the CIO. Moreover, it is not clear how to choose efficient channels for the ideal observer. In the current work, we investigate the use of singular vectors of a linear imaging system as efficient channels for the ideal observer in the same tasks. Singular value decomposition of the imaging system is performed to obtain its singular vectors. Singular vectors most relevant to the signal and background images are chosen as candidate channels. Results indicate that the singular vectors are not only more efficient than Laguerre-Gauss channels, but are also highly efficient for the ideal observer. The results further demonstrate that singular vectors strongly associated with the signal-only image are the most efficient channels.

  3. Structural controls on the development of submarine channel/fan systems since the Pleistocene in the accretionary wedge off SW Taiwan

    NASA Astrophysics Data System (ADS)

    Shen, Kang-Nien; Tien-Shun Lin, Andrew; Lin, Che-Chuan; Liu, Char-Shine; Wang, Yunshuen

    2016-04-01

    The accretionary wedge off SW Taiwan is the result of incipient arc-continent collision between the Luzon volcanic arc and the northern rifted margin of the South China Sea (SCS). Dynamic interactions of thrusting, folding and a rigorous sediment supply from the Taiwan mountain belts have resulted in two arrays of canyons/channels and slope-fan systems in the accretionary wedge. The Penghu canyon/fan system lies in the lower wedge and near the northern rifted margin of the SCS. The Penghu canyon is a river-fed canyon and receives sediments from southern Taiwan and SE China during eustatic lowstands. It becomes detached from river inputs during eustatic highstands as it is in the present-day. The Gaoping canyon/fan system in the south traverses both the upper slope and lower slope domains of the accretionary wedge. This system is a river-fed system during a full eustatic cycle and it drains sediments from the onshore Gaoping River. We interpreted multiple grids of multichannel seismic reflection data of MCS994, MCS1000-6, MCS1014, MCS1046 collected onboard Ocean Research I during 2012 April to 2013 August to map out thrust/fold structures and channel/fan systems in the study area. Seismic facies analyses were performed on seismic sections and key stratal surfaces of base of Pliocene and base of Pleistocene are correlated from boreholes drilled in the shelf of the northern SCS margin. Our results show that the upper Gaoping Canyon has been confined by structural ridges with limited switching of canyon courses, whereas the lower Gaoping canyon/fan system has been developed on lower slope with channel/levee deposition in multiple slope fans since early Pleistocene. Pleistocene lateral aggrading channel-and-levee systems are especially evident near the modern canyon course in the lower slope. The Penghu can/fan system in the lower accretionary wedge is also evident by seismic facies showing channel cut-and-fill, channel abandonment and channel-and-levee systems. This

  4. Environmental tests of a digital safety channel: An investigation of stress-related vulnerabilities of computer-based safety system

    SciTech Connect

    Korsah, K.; Wilson, T.L.; Wood, R.; Tanaka, T.

    1997-01-01

    This article presents the results of environmental stress tests performed on an experimental digital safety channel (EDSC) assembled at the Oak Ridge National Laboratory as part of the Qualification of Advanced Instrumentation and Controls Systems Research program, which was sponsored by the US Nuclear Regulatory Commission. The program is expected to provide recommendations for environmental qualification of digital safety systems. The purpose of the study was to investigate potential vulnerabilities of distributed computer systems used in safety applications when subjected to environmental stressors. The EDSC assembled for the tests employs technologies and digital subsystems representative of those proposed for use in advanced light-water reactors or as retrofits in existing plants. Subsystems include computers, electrical and optical serial communication links, fiber-optic network links, analog-to-digital and digital-to-analog converters, and multiplexers. The EDSC was subjected to selected stressors that are a potential risk to digital equipment in a mild environment. The selected stressors were electromagnetic and radiofrequency interferences (EMI-RFI), temperature, humidity, and smoke exposure. The stressors were applied at levels of intensity considerably higher than the safety channel is likely to experience in a normal nuclear power plant environment. Ranges of stress were selected at a sufficiently high level to induce errors so that failure modes that are characteristic of the technologies employed could be identified. On the basis of the incidence of functional errors observed during testing, EMI-RFI, smoke exposure, and high temperature coupled with high relative humidity, in that order, were found to have the greatest impact of the stressors investigated. The most prevalent stressor-induced upsets, as well as the most severe, were found to occur during the EMI-RFI tests.

  5. SEMICONDUCTOR INTEGRATED CIRCUITS: A four-channel microelectronic system for neural signal regeneration

    NASA Astrophysics Data System (ADS)

    Shushan, Xie; Zhigong, Wang; Xiaoying, Lü; Wenyuan, Li; Haixian, Pan

    2009-12-01

    This paper presents a microelectronic system which is capable of making a signal record and functional electric stimulation of an injured spinal cord. As a requirement of implantable engineering for the regeneration microelectronic system, the system is of low noise, low power, small size and high performance. A front-end circuit and two high performance OPAs (operational amplifiers) have been designed for the system with different functions, and the two OPAs are a low-noise low-power two-stage OPA and a constant-gm RTR input and output OPA. The system has been realized in CSMC 0.5-μm CMOS technology. The test results show that the system satisfies the demands of neuron signal regeneration.

  6. Practical considerations for a four-channel multiplexed Bragg grating fiber sensor system

    NASA Astrophysics Data System (ADS)

    Alavie, A. Tino; Ohn, Myo M.; Glennie, Derek J.; Karr, Shawn E.; Maaskant, Robert; Fishbein, G.; Lee, R.; Huang, Shang Yuan; Measures, Raymond M.

    1994-02-01

    A multichannel Bragg grating fiber laser demodulation system capable of interrogating four or more Bragg grating sensors for strain and temperature monitoring has been designed and developed. System configuration and various practical considerations for a field deployable system are discussed. Preliminary data indicates a dynamic strain range in excess of 5000 (mu) (epsilon) at a resolution of 1 (mu) (epsilon) . Both the strain dynamic range and resolution are easily modified.

  7. The insulin sensitizing effect of topiramate involves KATP channel activation in the central nervous system

    PubMed Central

    Coomans, C P; Geerling, J J; van den Berg, S A A; van Diepen, H C; Garcia-Tardón, N; Thomas, A; Schröder-van der Elst, J P; Ouwens, D M; Pijl, H; Rensen, P C N; Havekes, L M; Guigas, B; Romijn, J A

    2013-01-01

    BACKGROUND AND PURPOSE Topiramate improves insulin sensitivity, in addition to its antiepileptic action. However, the underlying mechanism is unknown. Therefore, the present study was aimed at investigating the mechanism of the insulin-sensitizing effect of topiramate both in vivo and in vitro. EXPERIMENTAL APPROACH Male C57Bl/6J mice were fed a run-in high-fat diet for 6 weeks, before receiving topiramate or vehicle mixed in high-fat diet for an additional 6 weeks. Insulin sensitivity was assessed by hyperinsulinaemic-euglycaemic clamp. The extent to which the insulin sensitizing effects of topiramate were mediated through the CNS were determined by concomitant i.c.v. infusion of vehicle or tolbutamide, an inhibitor of ATP-sensitive potassium channels in neurons. The direct effects of topiramate on insulin signalling and glucose uptake were assessed in vivo and in cultured muscle cells. KEY RESULTS In hyperinsulinaemic-euglycaemic clamp conditions, therapeutic plasma concentrations of topiramate (∼4 μg·mL−1) improved insulin sensitivity (glucose infusion rate + 58%). Using 2-deoxy-D-[3H]glucose, we established that topiramate improved the insulin-mediated glucose uptake by heart (+92%), muscle (+116%) and adipose tissue (+586%). Upon i.c.v. tolbutamide, the insulin-sensitizing effect of topiramate was completely abrogated. Topiramate did not directly affect glucose uptake or insulin signalling neither in vivo nor in cultured muscle cells. CONCLUSION AND IMPLICATIONS In conclusion, topiramate stimulates insulin-mediated glucose uptake in vivo through the CNS. These observations illustrate the possibility of pharmacological modulation of peripheral insulin resistance through a target in the CNS. PMID:23957854

  8. Ultrasonic Digital Communication System for a Steel Wall Multipath Channel: Methods and Results

    SciTech Connect

    Murphy, Timothy L.

    2005-12-01

    As of the development of this thesis, no commercially available products have been identified for the digital communication of instrumented data across a thick ({approx} 6 n.) steel wall using ultrasound. The specific goal of the current research is to investigate the application of methods for digital communication of instrumented data (i.e., temperature, voltage, etc.) across the wall of a steel pressure vessel. The acoustic transmission of data using ultrasonic transducers prevents the need to breach the wall of such a pressure vessel which could ultimately affect its safety or lifespan, or void the homogeneity of an experiment under test. Actual digital communication paradigms are introduced and implemented for the successful dissemination of data across such a wall utilizing solely an acoustic ultrasonic link. The first, dubbed the ''single-hop'' configuration, can communicate bursts of digital data one-way across the wall using the Differential Binary Phase-Shift Keying (DBPSK) modulation technique as fast as 500 bps. The second, dubbed the ''double-hop'' configuration, transmits a carrier into the vessel, modulates it, and retransmits it externally. Using a pulsed carrier with Pulse Amplitude Modulation (PAM), this technique can communicate digital data as fast as 500 bps. Using a CW carrier, Least Mean-Squared (LMS) adaptive interference suppression, and DBPSK, this method can communicate data as fast as 5 kbps. A third technique, dubbed the ''reflected-power'' configuration, communicates digital data by modulating a pulsed carrier by varying the acoustic impedance at the internal transducer-wall interface. The paradigms of the latter two configurations are believed to be unique. All modulation methods are based on the premise that the wall cannot be breached in any way and can therefore be viably implemented with power delivered wirelessly through the acoustic channel using ultrasound. Methods, results, and considerations for future research are discussed

  9. Biofloc technology production systems reduce common preharvest off-flavors in channel catfish

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The use of biofloc technology production systems continues to increase in the aquaculture industry worldwide. Studies have not previously been performed to determine the composition of phytoplankton communities and related off-flavor problems in these biofloc production systems. In two separate st...

  10. ETV Report: Siemens Model V-40R-A150 Open Channel UV System

    EPA Science Inventory

    Verification testing of the Siemens Barrier Sunlight V-40R-A150 UV System was completed at the UV Validation and Research Center of New York (UV Center), located in Johnstown, NY. The V-40R System supplied by Siemens utilizes 40 high-output, low-pressure amalgam lamps, oriented ...

  11. ETV Report:Siemens Model H-4XE-HO Open Channel UV System

    EPA Science Inventory

    Verification testing of the Siemens Barrier Sunligt H-4XE-HO UV System was completed at the UV Validation and Research Center of New York (UV Center), located in Johnstown, NY. The H-4XE System utilizes 16 high-output, low-pressure lamps oriented horizontally and parallel to the...

  12. Micro-channel plate detector

    SciTech Connect

    Elam, Jeffrey W.; Lee, Seon W.; Wang, Hsien -Hau; Pellin, Michael J.; Byrum, Karen; Frisch, Henry J.

    2015-09-22

    A method and system for providing a micro-channel plate detector. An anodized aluminum oxide membrane is provided and includes a plurality of nanopores which have an Al coating and a thin layer of an emissive oxide material responsive to incident radiation, thereby providing a plurality of radiation sensitive channels for the micro-channel plate detector.

  13. Numerical and Experimental Investigation of Natural Convection in Open-Ended Channels with Application to Building Integrated Photovoltaic (BIPV) Systems

    NASA Astrophysics Data System (ADS)

    Timchenko, V.; Tkachenko, O. A.; Giroux-Julien, S.; Ménézo, C.

    2015-05-01

    Numerical and experimental investigations of the flow and heat transfer in open-ended channel formed by the double skin façade have been undertaken in order to improve understanding of the phenomena and to apply it to passive cooling of building integrated photovoltaic systems. Both uniform heating and non-uniform heating configurations in which heat sources alternated with unheated zones on both skins were studied. Different periodic and asymmetric heating modes have been considered for the same aspect ratio 1/15 of wall distance to wall height and for periodicity 1/15 and 4/15 of heated/unheated zones and heat input, 220 W/m2. In computational study three dimensional transient LES simulation was carried out. It is shown that in comparison to uniformly heating configuration, non-uniformly heating configuration enhances both convective heat transfer and chimney effect.

  14. Development of phytoplankton communities and common off-flavors in a biofloc technology system used for the culture of channel catfish (Ictalurus punctatus)

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The use of biofloc technology production systems continues to increase in the aquaculture industry worldwide. Recent research demonstrated that outdoor biofloc systems can be used to produce high yields of channel catfish (Ictalurus punctatus). However, studies have not yet been performed to deter...

  15. Development of phytoplankton communities and common off-flavors in a biofloc technology system used to culture channel catfish Ictalurus punctatus

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The use of biofloc technology production systems continues to increase in the aquaculture industry worldwide. Recent research demonstrated that outdoor biofloc systems can be used to produce high yields of channel catfish (Ictalurus punctatus). However, studies have not yet been performed to deter...

  16. The Telecom 1 satellite system - Architecture of the common channel signalling network

    NASA Astrophysics Data System (ADS)

    Guenin, J. P.; Benard-Dende, J. C.; Choi, Y.; Hoang-van, A.

    The Telecom 1 satellite system will be the first French public multiservice digital network for large corporate and professional customers, rendering such services as telephony, low speed data transmission, high speed computer communications, and videoconferencing. Two novel features of the system, designated 'part-time leased-line service' and 'broadcast facility', are suitable for the implementation of advanced computer networking applications such as distributed data bases, network job entry systems, and backup or load-sharing among computer centers. Access to Telecom 1 services is by way of about 300 stations throughout Europe, concentrated in France.

  17. Experimental research and comparison of LDPC and RS channel coding in ultraviolet communication systems.

    PubMed

    Wu, Menglong; Han, Dahai; Zhang, Xiang; Zhang, Feng; Zhang, Min; Yue, Guangxin

    2014-03-10

    We have implemented a modified Low-Density Parity-Check (LDPC) codec algorithm in ultraviolet (UV) communication system. Simulations are conducted with measured parameters to evaluate the LDPC-based UV system performance. Moreover, LDPC (960, 480) and RS (18, 10) are implemented and experimented via a non-line-of-sight (NLOS) UV test bed. The experimental results are in agreement with the simulation and suggest that based on the given power and 10(-3)bit error rate (BER), in comparison with an uncoded system, average communication distance increases 32% with RS code, while 78% with LDPC code.

  18. Jamming in Vertical Channels

    NASA Astrophysics Data System (ADS)

    Baxter, G. William; McCausland, Jeffrey; Steel, Fiona

    2010-03-01

    We experimentally study jamming of cylindrical grains in a vertical channel. The grains have a low aspect-ratio (height/diameter < 1) so their shape is like antacid tablets or poker chips. They are allowed to fall through a vertical channel with a square cross section. The channel width is greater than the diameter of a grain and constant throughout the length of the channel with no obstructions or constrictions. It is observed that grains sometimes jam in this apparatus. In a jam, grains form a stable structure from one side of the channel to the other with nothing beneath them. Jams may be strong enough to support additional grains above. The probability of a jam occurring is a function of the grain height and diameter. We will present experimental measurements of the jamming probability in this system and discuss the relationship of these results to other experiments and theories.

  19. TRP Channels

    NASA Astrophysics Data System (ADS)

    Voets, Thomas; Owsianik, Grzegorz; Nilius, Bernd

    The TRP superfamily represents a highly diverse group of cation-permeable ion channels related to the product of the Drosophila trp (transient receptor potential) gene. The cloning and characterization of members of this cation channel family has experienced a remarkable growth during the last decade, uncovering a wealth of information concerning the role of TRP channels in a variety of cell types, tissues, and species. Initially, TRP channels were mainly considered as phospholipase C (PLC)-dependent and/or store-operated Ca2+-permeable cation channels. More recent research has highlighted the sensitivity of TRP channels to a broad array of chemical and physical stimuli, allowing them to function as dedicated biological sensors involved in processes ranging from vision to taste, tactile sensation, and hearing. Moreover, the tailored selectivity of certain TRP channels enables them to play key roles in the cellular uptake and/or transepithelial transport of Ca2+, Mg2+, and trace metal ions. In this chapter we give a brief overview of the TRP channel superfamily followed by a survey of current knowledge concerning their structure and activation mechanisms.

  20. Space-for-time substitution and the evolution of a submarine canyon-channel system in a passive progradational margin

    NASA Astrophysics Data System (ADS)

    Micallef, Aaron; Ribó, Marta; Canals, Miquel; Puig, Pere; Lastras, Galderic; Tubau, Xavier

    2014-09-01

    Space-for-time substitution is a concept that has been widely applied, but not thoroughly tested, in some fields of geomorphology. The objective of this study is to test whether the concept of space-for-time substitution is valid in reconstructing the evolution of a submarine canyon-channel system in a passive progradational margin. We use multibeam echosounder data and in situ measurements from the south Ebro Margin to analyse the morphology and morphometry of a sequence of submarine valleys ordered in terms of increasing valley thalweg length. The morphological model of submarine valley evolution that we can propose from this analysis is very similar to established models in the literature, which leads us to conclude that time can be substituted by space when reconstructing the evolution of submarine canyon and channel systems in the south Ebro Margin. By extracting morphometric information from the application of the space-for-time substitution model to our data, we identify a series of morphological patterns as a submarine canyon evolves in a passive progradational margin. These include the geometric similarity of canyon planform shape, an increase in canyon draining efficiency and in the influence of flank slope failures, and an evolution towards equilibrium between canyon form and imposed water and sediment load without net erosion or deposition taking place. We also observe that canyon elongation is higher downslope and that the canyon undergoes an early stage of rapid incision similar to the process of "erosion narrowing" reported in terrestrial rivers. We demonstrate that the conclusions of our study are not limited to submarine valleys in the south Ebro Margin but are applicable to other margins around the world.

  1. Impact of organic nutrient load on biomass accumulation, feed channel pressure drop increase and permeate flux decline in membrane systems.

    PubMed

    Bucs, Sz S; Valladares Linares, R; van Loosdrecht, M C M; Kruithof, J C; Vrouwenvelder, J S

    2014-12-15

    The influence of organic nutrient load on biomass accumulation (biofouling) and pressure drop development in membrane filtration systems was investigated. Nutrient load is the product of nutrient concentration and linear flow velocity. Biofouling - excessive growth of microbial biomass in membrane systems - hampers membrane performance. The influence of biodegradable organic nutrient load on biofouling was investigated at varying (i) crossflow velocity, (ii) nutrient concentration, (iii) shear, and (iv) feed spacer thickness. Experimental studies were performed with membrane fouling simulators (MFSs) containing a reverse osmosis (RO) membrane and a 31 mil thick feed spacer, commonly applied in practice in RO and nanofiltration (NF) spiral-wound membrane modules. Numerical modeling studies were done with identical feed spacer geometry differing in thickness (28, 31 and 34 mil). Additionally, experiments were done applying a forward osmosis (FO) membrane with varying spacer thickness (28, 31 and 34 mil), addressing the permeate flux decline and biofilm development. Assessed were the development of feed channel pressure drop (MFS studies), permeate flux (FO studies) and accumulated biomass amount measured by adenosine triphosphate (ATP) and total organic carbon (TOC). Our studies showed that the organic nutrient load determined the accumulated amount of biomass. The same amount of accumulated biomass was found at constant nutrient load irrespective of linear flow velocity, shear, and/or feed spacer thickness. The impact of the same amount of accumulated biomass on feed channel pressure drop and permeate flux was influenced by membrane process design and operational conditions. Reducing the nutrient load by pretreatment slowed-down the biofilm formation. The impact of accumulated biomass on membrane performance was reduced by applying a lower crossflow velocity and/or a thicker and/or a modified geometry feed spacer. The results indicate that cleanings can be delayed

  2. Trellis coded multilevel DPSK system with doppler correction for mobile satellite channels

    NASA Technical Reports Server (NTRS)

    Divsalar, Dariush (Inventor); Simon, Marvin K. (Inventor)

    1991-01-01

    A trellis coded multilevel differential phase shift keyed mobile communication system. The system of the present invention includes a trellis encoder for translating input signals into trellis codes; a differential encoder for differentially encoding the trellis coded signals; a transmitter for transmitting the differentially encoded trellis coded signals; a receiver for receiving the transmitted signals; a differential demodulator for demodulating the received differentially encoded trellis coded signals; and a trellis decoder for decoding the differentially demodulated signals.

  3. Breadboard model of a coherent optical BPSK homodyne system with virtual pilot tone (ViP)-based receiver and MRC auxiliary channel

    NASA Astrophysics Data System (ADS)

    David, Florian; Rapp, Christoph

    2000-05-01

    This paper presents a bread-board model of an optical BPSK homodyne system. A new phase synchronization method--the so- called Virtual Pilot-tone method--enables a dramatic reduction of the system completely. Although fully compatible to the transmit signal of a high data rate Costas Loop system, the receiver design is enormously simplified. Neither an optical 90 degree(s) hybrid nor digital high speed electronics are needed. An additional low data rate auxiliary channel is provided by using a Modulated Residual Carrier and envelope detection.The data rate of this auxiliary channel has to be well below that of the main channel, but is sufficient for transmitting e.g. telemetry data. Both methods and their realization are explained. Simulation and practical results are displayed and compared to a standard Costas Loop design.

  4. A Tone-Aided/Dual Vestigial Sideband (TA/DVSB) system for mobile satellite channels

    NASA Technical Reports Server (NTRS)

    Saulnier, Gary J.; Millar, Gilbert M.; Depaolo, Anthony D.

    1990-01-01

    Tone-aided modulation is one way of combatting the effects of multipath fading and Doppler frequency shifts. A new tone-aided modulation format for M-ary phase-shift keyed signals (MPSK) is discussed. A spectral null for the placement of the tone is created in the center of the MPSK signal by translating the upper sideband upwards in frequency by the same amount. The key element of the system is the algorithm for recombining the data sidebands in the receiver, a function that is performed by a specialized phase-locked loop (PLL). The system structure is discussed and simulation results showing the PLL acquisition performance are presented.

  5. High-speed connections for storage systems; HIPPI, fibre channel, and ATM: Whats happening?

    SciTech Connect

    Tolmie, D.E.

    1995-04-01

    A group of eight Digital Equipment Corporation Alpha workstations is interconnected with ATM to form a cluster with supercomputer power. For output, each workstation drives a single ``tile`` on an 8-tile high-resolution frame buffer. A special purpose adapter is used to convert the workstation`s ATM format to the frame buffer`s HIPPI format. This paper discusses the rationale behind the workstation farm, and then describes the visualization output path in detail. To provide the system quickly, special emphasis was placed on making the design as simple as possible. The design choices are examined, and the resultant system is described. The oral presentation will include operational experiences.

  6. Performance analysis of relay-aided free-space optical communication system over gamma-gamma fading channels with pointing errors

    NASA Astrophysics Data System (ADS)

    Fu, Hui-hua; Wang, Ping; Wang, Ran-ran; Liu, Xiao-xia; Guo, Li-xin; Yang, Yin-tang

    2016-07-01

    The average bit error rate ( ABER) performance of a decode-and-forward (DF) based relay-assisted free-space optical (FSO) communication system over gamma-gamma distribution channels considering the pointing errors is studied. With the help of Meijer's G-function, the probability density function (PDF) and cumulative distribution function (CDF) of the aggregated channel model are derived on the basis of the best path selection scheme. The analytical ABER expression is achieved and the system performance is then investigated with the influence of pointing errors, turbulence strengths and structure parameters. Monte Carlo (MC) simulation is also provided to confirm the analytical ABER expression.

  7. In-service communication channel sensing based on reflectometry for dynamic wavelength assigned wavelength- and time-division multiplexed passive optical network systems

    NASA Astrophysics Data System (ADS)

    Iida, Daisuke; Kuwano, Shigeru; Terada, Jun

    2015-04-01

    In future radio access systems, base stations will be mainly accommodated in wavelength- and time-division multiplexing passive optical network (PON) based mobile backhaul and fronthaul networks, and in such networks, failed connections in an optical network unit (ONU) wavelength channel will severely degrade mobile system performance. A cost-effective in-service ONU wavelength channel monitor is essential to ensure proper system operation without failed connections. To address this issue, we propose a reflectometry-based remote sensing method that provides ONU wavelength channel information with the optical line terminal-ONU distance. The proposed method enables real-time monitoring of ONU wavelength channels without data signal quality degradation and is also able to determine if the ONUs are connected to the PON. Experimental results show that it achieves wavelength channel distinction with a high distance resolution (˜10 m). Additionally, with the method, the distance resolution for distinguishing the ONUs after the PON splitter is determined by the received signal bandwidth or the test light modulation speed rather than by the pulse width as in conventional optical time-domain reflectometry.

  8. A low-noise 64-channel front-end readout ASIC for CdZnTe detectors aimed to hard X-ray imaging systems

    NASA Astrophysics Data System (ADS)

    Gan, B.; Wei, T.; Gao, W.; Liu, H.; Hu, Y.

    2016-04-01

    In this paper, we report on the recent development of a 64-channel low-noise front-end readout ASIC for CdZnTe detectors aimed to hard X-ray imaging systems. The readout channel is comprised of a charge sensitive amplifier, a leakage current compensation circuit, a CR-RC shaper, two S-K filters, an inverse proportional amplifier, a peak-detect-and-hold circuit, a discriminator and trigger logic, a time sequence control circuit and a driving buffer. The readout ASIC is implemented in TSMC 0.35 μm mixed-signal CMOS technology, the die size of the prototype chip is 2.7 mm×8.0 mm. The overall gain of the readout channel is 200 mV/fC, the power consumption is less than 8 mW/channel, the linearity error is less than 1%, the inconsistency among the channels is less than 2.86%, and the equivalent noise charge of a typical channel is 66 e- at zero farad plus 14 e- per picofarad. By connecting this readout ASIC to an 8×8 pixel CdZnTe detector, we obtained an energy spectrum, the energy resolution of which is 4.5% at the 59.5 keV line of 241Am source.

  9. Preparation of hybrid soda-lime/quartz glass chips with wettability-patterned channels for manipulation of flow profiles in droplet-based analytical systems.

    PubMed

    Bai, Zeqing; He, Qiaohong; Huang, Shanshi; Hu, Xianqiao; Chen, Hengwu

    2013-03-12

    Profile switching of two-phase flows is often required in microfluidic systems. Manipulation of flow profiles can be realized by control of local surface energy of micro channel through wettability-patterning of channel surface. This article presents a facile approach for wettability-patterning of the micro channels of glass chips. Commercially available octadecyltrichlorosilane (OTS) was used to hydrophobilize the channels via the formation of OTS self-assembly monolayer (SAM), and a UV-source that mainly emits deep UV-light of 254 and 185 nm was employed to degrade the in-channel formed OTS-SAM. The architecture of soda-lime glass/quartz glass hybrid chip was designed to facilitate the deep UV-light effective degrading the OTS-SAM. The established approach, together with the side-by-side laminar-flow patterning technique, was applied to prepare various finely patterned channel networks for different tasks of flow profile switching. The micro device capable of conducting the profile switch from W/O droplets to two separated continuous phases was demonstrated to perform on-chip quick liquid-liquid extraction for the determination of partition coefficients of pharmaceuticals.

  10. A transgenic zebrafish model of a human cardiac sodium channel mutation exhibits bradycardia, conduction-system abnormalities and early death.

    PubMed

    Huttner, Inken G; Trivedi, Gunjan; Jacoby, Arie; Mann, Stefan A; Vandenberg, Jamie I; Fatkin, Diane

    2013-08-01

    The recent exponential increase in human genetic studies due to the advances of next generation sequencing has generated unprecedented numbers of new gene variants. Determining which of these are causative of human disease is a major challenge. In-vitro studies and murine models have been used to study inherited cardiac arrhythmias but have several limitations. Zebrafish models provide an attractive alternative for modeling human heart disease due to similarities in cardiac electrophysiology and contraction, together with ease of genetic manipulation, external development and optical transparency. Although zebrafish cardiac mutants and morphants have been widely used to study loss and knockdown of zebrafish gene function, the phenotypic effects of human dominant-negative gene mutations expressed in transgenic zebrafish have not been evaluated. The aim of this study was to generate and characterize a transgenic zebrafish arrhythmia model harboring the pathogenic human cardiac sodium channel mutation SCN5A-D1275N, that has been robustly associated with a range of cardiac phenotypes, including conduction disease, sinus node dysfunction, atrial and ventricular arrhythmias, and dilated cardiomyopathy in humans and in mice. Stable transgenic fish with cardiac expression of human SCN5A were generated using Tol2-mediated transgenesis and cardiac phenotypes were analyzed using video microscopy and ECG. Here we show that transgenic zebrafish expressing the SCN5A-D1275N mutation, but not wild-type SCN5A, exhibit bradycardia, conduction-system abnormalities and premature death. We furthermore show that SCN5A-WT, and to a lesser degree SCN5A-D1275N, are able to compensate the loss of endogenous zebrafish cardiac sodium channels, indicating that the basic pathways, through which SCN5A acts, are conserved in teleosts. This proof-of-principle study suggests that zebrafish may be highly useful in vivo models to differentiate functional from benign human genetic variants in cardiac

  11. Development of digital flow control system for multi-channel variable-rate sprayers

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Precision modulation of nozzle flow rates is a critical step for variable-rate spray applications in orchards and ornamental nurseries. An automatic flow rate control system activated with microprocessors and pulse width modulation (PWM) controlled solenoid valves was developed to control flow rates...

  12. Widefield TSCSPC-systems with large-area-detectors: application in simultaneous multi-channel-FLIM

    NASA Astrophysics Data System (ADS)

    Stepanov, Sergei; Bakhlanov, Sergei; Drobchenko, Evgeny; Eckert, Hann-Jörg; Kemnitz, Klaus

    2010-11-01

    Novel proximity-type Time- and Space-Correlated Single Photon Counting (TSCSPC) crossed-delay-line (DL)- and multi-anode (MA)-systems of outstanding performance and homogeneity were developed, using large-area detector heads of 25 and 40 mm diameter. Instrument response functions IRF(space) = (60 +/- 5) μm FWHM and IRF(time) = (28 +/- 3) ps FWHM were achieved over the full 12 cm2 area of the detector. Deadtime at throughput of 105 cps is 10% for "high-resolution" system and 5% in the "video"-system at 106 cps, at slightly reduced time- and space resolution. A fluorescence lifetime of (3.5 +/- 1) ps can be recovered from multi-exponential dynamics of a single living cyanobacterium (Acaryochloris marina). The present large-area detectors are particularly useful in simultaneous multichannel applications, such as 2-colour anisotropy or 4-colour lifetime imaging, utilizing dual- or quad-view image splitters. The long-term stability, low- excitation-intensity (< 100 mW/cm2) widefield systems enable minimal-invasive observation, without significant bleaching or photodynamic reactions, thus allowing long-period observation of up to several hours in living cells.

  13. Two chaos synchronization schemes and public-channel message transmission in a mutually coupled semiconductor lasers system

    NASA Astrophysics Data System (ADS)

    Jiang, Ning; Pan, Wei; Yan, Lianshan; Luo, Bin; Yang, Lei; Xiang, Shuiying; Zheng, Di

    2009-06-01

    Chaos synchronization and message transmission of a mutually coupled system consisting of two semiconductor lasers (SLs) and a partially transparent mirror (PTM) in between are investigated theoretically. Analytical results show that two types of chaos synchronization schemes, named as isochronal synchronization (IS) and leader/laggard synchronization (LLS), can be achieved by adjusting the reflectivity and position of PTM. By establishing SIMULINK model, numerical simulations illustrate that as the PTM is positioned at the center of two lasers, IS is available when the reflectivity of PTM is moderate. The LLS is achieved when the reflectivity of PTM equals to 0.5, which means feedback strength equals to coupling strength. Its lag time is just determined by the difference of feedback delay time. The investigations of mutual chaos pass filtering (MCPF) effects and the secure chaotic communication simulations indicate that IS allows real-time bidirectional message transmission on a public-channel, while LLS can achieve higher security chaotic communication by using its lag time as cryptography key. The demonstrated system can be used as a rudiment of array chaos communications system.

  14. Dual-channel in-situ optical imaging system for quantifying lipid uptake and lymphatic pump function

    NASA Astrophysics Data System (ADS)

    Kassis, Timothy; Kohan, Alison B.; Weiler, Michael J.; Nipper, Matthew E.; Cornelius, Rachel; Tso, Patrick; Brandon Dixon, J.

    2012-08-01

    Nearly all dietary lipids are transported from the intestine to venous circulation through the lymphatic system, yet the mechanisms that regulate this process remain unclear. Elucidating the mechanisms involved in the functional response of lymphatics to changes in lipid load would provide valuable insight into recent implications of lymphatic dysfunction in lipid related diseases. Therefore, we sought to develop an in situ imaging system to quantify and correlate lymphatic function as it relates to lipid transport. The imaging platform provides the capability of dual-channel imaging of both high-speed bright-field video and fluorescence simultaneously. Utilizing post-acquisition image processing algorithms, we can quantify correlations between vessel pump function, lymph flow, and lipid concentration of mesenteric lymphatic vessels in situ. All image analysis is automated with customized LabVIEW virtual instruments; local flow is measured through lymphocyte velocity tracking, vessel contraction through measurements of the vessel wall displacement, and lipid uptake through fluorescence intensity tracking of an orally administered fluorescently labelled fatty acid analogue, BODIPY FL C16. This system will prove to be an invaluable tool for scientists studying intestinal lymphatic function in health and disease, and those investigating strategies for targeting the lymphatics with orally delivered drugs to avoid first pass metabolism.

  15. Can water sensitive urban design systems help to preserve natural channel-forming flow regimes in an urbanised catchment?

    PubMed

    Wella-Hewage, Chathurika Subhashini; Alankarage Hewa, Guna; Pezzaniti, David

    2016-01-01

    Increased stormwater runoff and pollutant loads due to catchment urbanisation bring inevitable impacts on the physical and ecological conditions of environmentally sensitive urban streams. Water sensitive urban design (WSUD) has been recognised as a possible means to minimise these negative impacts. This paper reports on a study that investigated the ability of infiltration-based WSUD systems to replicate the predevelopment channel-forming flow (CFF) regime in urban catchments. Catchment models were developed for the 'pre-urban', 'urban' and 'managed' conditions of a case study catchment and the hydrological effect on CFF regime was investigated using a number of flow indices. The results clearly show that changes to flow regime are apparent under urban catchment conditions and are even more severe under highly urbanised conditions. The use of WSUD systems was found to result in the replication of predevelopment flow regimes, particularly at low levels of urbanisation. Under highly urbanised conditions (of managed catchments) overcontrol of the CFF indices was observed as indicated by flow statistics below their pre-urban values. The overall results suggest that WSUD systems are highly effective in replicating the predevelopment CFF regime in urban streams and could be used as a means to protect environmentally sensitive urban streams.

  16. Performance study of terrestrial multi-hop OFDM FSO communication systems with pointing errors over turbulence channels

    NASA Astrophysics Data System (ADS)

    Nistazakis, H. E.; Ninos, M. P.; Tsigopoulos, A. D.; Zervos, D. A.; Tombras, G. S.

    2016-08-01

    The free-space optical communication systems attract significant research and commercial interest the last few years, due to their high performance and reliability characteristics along with their, relatively, low installation and operational cost. Moreover, due to the fact that these systems are using the atmosphere as propagation path, their performance is varying according to its characteristics. Here, we present the performance analysis of a serially relayed radio-on-free-space-optical (RoFSO) communication system which employs the orthogonal frequency division multiplexing technique, with a quadrature amplitude modulation scheme, over atmospheric turbulence channels modelled by either the Gamma-Gamma or the Gamma distribution model. For this RoFSO communication link, we derive closed-form mathematical expressions for the estimation of its average bit error rate and outage probability, taking into account the relays' number, the atmospheric turbulence and the pointing errors effect. Furthermore, for realistic parameter values, numerical results are presented using the derived mathematical expressions, which are verified through the corresponding numerical simulations.

  17. Can water sensitive urban design systems help to preserve natural channel-forming flow regimes in an urbanised catchment?

    PubMed

    Wella-Hewage, Chathurika Subhashini; Alankarage Hewa, Guna; Pezzaniti, David

    2016-01-01

    Increased stormwater runoff and pollutant loads due to catchment urbanisation bring inevitable impacts on the physical and ecological conditions of environmentally sensitive urban streams. Water sensitive urban design (WSUD) has been recognised as a possible means to minimise these negative impacts. This paper reports on a study that investigated the ability of infiltration-based WSUD systems to replicate the predevelopment channel-forming flow (CFF) regime in urban catchments. Catchment models were developed for the 'pre-urban', 'urban' and 'managed' conditions of a case study catchment and the hydrological effect on CFF regime was investigated using a number of flow indices. The results clearly show that changes to flow regime are apparent under urban catchment conditions and are even more severe under highly urbanised conditions. The use of WSUD systems was found to result in the replication of predevelopment flow regimes, particularly at low levels of urbanisation. Under highly urbanised conditions (of managed catchments) overcontrol of the CFF indices was observed as indicated by flow statistics below their pre-urban values. The overall results suggest that WSUD systems are highly effective in replicating the predevelopment CFF regime in urban streams and could be used as a means to protect environmentally sensitive urban streams. PMID:26744937

  18. Dual-channel in-situ optical imaging system for quantifying lipid uptake and lymphatic pump function

    PubMed Central

    Kassis, Timothy; Kohan, Alison B.; Weiler, Michael J.; Nipper, Matthew E.; Cornelius, Rachel; Tso, Patrick

    2012-01-01

    Abstract. Nearly all dietary lipids are transported from the intestine to venous circulation through the lymphatic system, yet the mechanisms that regulate this process remain unclear. Elucidating the mechanisms involved in the functional response of lymphatics to changes in lipid load would provide valuable insight into recent implications of lymphatic dysfunction in lipid related diseases. Therefore, we sought to develop an in situ imaging system to quantify and correlate lymphatic function as it relates to lipid transport. The imaging platform provides the capability of dual-channel imaging of both high-speed bright-field video and fluorescence simultaneously. Utilizing post-acquisition image processing algorithms, we can quantify correlations between vessel pump function, lymph flow, and lipid concentration of mesenteric lymphatic vessels in situ. All image analysis is automated with customized LabVIEW virtual instruments; local flow is measured through lymphocyte velocity tracking, vessel contraction through measurements of the vessel wall displacement, and lipid uptake through fluorescence intensity tracking of an orally administered fluorescently labelled fatty acid analogue, BODIPY FL C16. This system will prove to be an invaluable tool for scientists studying intestinal lymphatic function in health and disease, and those investigating strategies for targeting the lymphatics with orally delivered drugs to avoid first pass metabolism. PMID:23224192

  19. An interactive 24-channel event-logging system based on the AIM 65 single-board microcomputer.

    PubMed

    Thomas, S R; Grimwood, M; Iversen, S D

    1984-06-01

    Measures of the spontaneous behaviour of animals commonly involve the repetitive counting of behavioural events over successive periods of time following some experimental treatment. An automated event-logging system has been designed for such applications. The system is based on an AIM 65 microcomputer with 4 Kbytes of random-access memory and facilities for manual event-logging through the keyboard, or automatic logging via a signal-conditioning buffer, connected to the backplane connector of the computer. The control program is written in 6500 machine code and stored in an onboard, read-only, memory chip. The software generates a simple interactive dialogue for the selection of operating options which include manual or automatic modes, configuration of active channels, duration and number of logging cycles, and the choice of printed or transmitted output. The microcomputer can also be instructed to pause and then to restart, to print out its current status, or to abort. The system has been used over a period of 18 months in numerous experiments in this laboratory, and has proved to be reliable, accurate and entirely suited to its application.

  20. Earth Observing System/Advanced Microwave Sounding Unit-A (EOS/AMSU-A): Reliability prediction report for module A1 (channels 3 through 15) and module A2 (channels 1 and 2)

    NASA Technical Reports Server (NTRS)

    Geimer, W.

    1995-01-01

    This report documents the final reliability prediction performed on the Earth Observing System/Advanced Microwave Sounding Unit-A (EOS/AMSU-A). The A1 Module contains Channels 3 through 15, and is referred to herein as 'EOS/AMSU-A1'. The A2 Module contains Channels 1 and 2, and is referred herein as 'EOS/AMSU-A2'. The 'specified' figures were obtained from Aerojet Reports 8897-1 and 9116-1. The predicted reliability figure for the EOS/AMSU-A1 meets the specified value and provides a Mean Time Between Failures (MTBF) of 74,390 hours. The predicted reliability figure for the EOS/AMSU-A2 meets the specified value and provides a MTBF of 193,110 hours.

  1. a Measuring System with AN Additional Channel for Eliminating the Dynamic Error

    NASA Astrophysics Data System (ADS)

    Dichev, Dimitar; Koev, Hristofor; Louda, Petr

    2014-03-01

    The present article views a measuring system for determining the parameters of vessels. The system has high measurement accuracy when operating in both static and dynamic mode. It is designed on a gyro-free principle for plotting a vertical. High accuracy of measurement is achieved by using a simplified design of the mechanical module as well by minimizing the instrumental error. A new solution for improving the measurement accuracy in dynamic mode is offered. The approach presented is based on a method where the dynamic error is eliminated in real time, unlike the existing measurement methods and tools where stabilization of the vertical in the inertial space is used. The results obtained from the theoretical experiments, which have been performed on the basis of the developed mathematical model, demonstrate the effectiveness of the suggested measurement approach.

  2. Method And Apparatus For Reducing Sample Dispersion In Turns And Junctions Of Micro-Channel Systems

    DOEpatents

    Griffiths, Stewart K. , Nilson, Robert H.

    2004-05-11

    What is disclosed pertains to improvement in the performance of microchannel devices by providing turns, wyes, tees, and other junctions that produce little dispersion of a sample as it traverses the turn or junction. The reduced dispersion results from contraction and expansion regions that reduce the cross-sectional area over some portion of the turn or junction. By carefully designing the geometries of these regions, sample dispersion in turns and junctions is reduced to levels comparable to the effects of ordinary diffusion. The low dispersion features are particularly suited for microfluidic devices and systems using either electromotive force, pressure, or combinations thereof as the principle of fluid transport. Such microfluidic devices and systems are useful for separation of components, sample transport, reaction, mixing, dilution or synthesis, or combinations thereof.

  3. Theoretical and experimental studies of polarization fluctuations over atmospheric turbulent channels for wireless optical communication systems.

    PubMed

    Zhang, Jiankun; Ding, Shengli; Zhai, Huili; Dang, Anhong

    2014-12-29

    In wireless optical communications (WOC), polarization multiplexing systems and coherent polarization systems have excellent performance and wide applications, while its state of polarization affected by atmospheric turbulence is not clearly understood. This paper focuses on the polarization fluctuations caused by atmospheric turbulence in a WOC link. Firstly, the relationship between the polarization fluctuations and the index of refraction structure parameter is introduced and the distribution of received polarization angle is obtained through theoretical derivations. Then, turbulent conditions are adjusted and measured elaborately in a wide range of scintillation indexes (SI). As a result, the root-mean-square (RMS) variation and probability distribution function (PDF) of polarization angle conforms closely to that of theoretical model.

  4. Channel Access in Erlang

    SciTech Connect

    Nicklaus, Dennis J.

    2013-10-13

    We have developed an Erlang language implementation of the Channel Access protocol. Included are low-level functions for encoding and decoding Channel Access protocol network packets as well as higher level functions for monitoring or setting EPICS process variables. This provides access to EPICS process variables for the Fermilab Acnet control system via our Erlang-based front-end architecture without having to interface to C/C++ programs and libraries. Erlang is a functional programming language originally developed for real-time telecommunications applications. Its network programming features and list management functions make it particularly well-suited for the task of managing multiple Channel Access circuits and PV monitors.

  5. Edge-Channel Photo-Effect In Asymmetric Two-Dimensional Systems

    SciTech Connect

    Vasilyev, Yu. B.; Meltser, B. Ya.; Ivanov, S. V.; Kop'ev, P. S.; Stellmach, C.; Gouider, F.; Nachtwei, G.

    2011-12-23

    We report on the photo-effect in an asymmetric two dimensional electron system where edge currents are induced by homogeneous terahertz (THz) radiation in tilted magnetic field without any external bias. We discuss the features of the observed effect and its mechanism taking into account properties of edge states in magnetic fields. The process is understood as the quantum Hall effect associated with electron-hole pairs generated in Landau levels by THz radiation under CR conditions.

  6. RF model of the distribution system as a communication channel, phase 2. Volume 2: Task reports

    NASA Technical Reports Server (NTRS)

    Rustay, R. C.; Gajjar, J. T.; Rankin, R. W.; Wentz, R. C.; Wooding, R.

    1982-01-01

    Based on the established feasibility of predicting, via a model, the propagation of Power Line Frequency on radial type distribution feeders, verification studies comparing model predictions against measurements were undertaken using more complicated feeder circuits and situations. Detailed accounts of the major tasks are presented. These include: (1) verification of model; (2) extension, implementation, and verification of perturbation theory; (3) parameter sensitivity; (4) transformer modeling; and (5) compensation of power distribution systems for enhancement of power line carrier communication reliability.

  7. Channel characterisation for future Ka-band Mobile Satellite Systems and preliminary results

    NASA Technical Reports Server (NTRS)

    Sforza, Mario; Buonomo, Sergio; Arbesser-Rastburg, Bertram

    1994-01-01

    Mobile satellite systems (MSS) are presently designed or planned to operate, with the exception of OMNITRACKS, in the lower part of the frequency spectrum (UHF to S-bands). The decisions taken at the last World Administrative Radio Conference in 1992 to increase the allocated L- and S-bands for MSS services will only partly alleviate the problem of system capacity. In addition the use of L-and S-band frequencies generally requires large antenna apertures on board the satellite terminal side. The idea of exploiting the large spectrum resources available at higher frequencies (20-30 GHz) and the perspective of reducing user terminal size (and possibly price too) have spurred the interest of systems designers and planners. On the other hand, Ka-band frequencies suffer from increased slant path losses due to atmospheric attenuation phenomena. The European Space Agency (ESA) has recently embarked on a number of activities aimed at studying the effect of the typical mobile propagation impairments at Ka-band. This paper briefly summarizes ESA efforts in this field of research and presents preliminary experimental results.

  8. A novel high channel-count system for acute multisite neuronal recordings.

    PubMed

    Hofmann, Ulrich G; Folkers, Andre; Mösch, Florian; Malina, Thomas; Menne, Kerstin M L; Biella, Gerardo; Fagerstedt, Patriq; De Schutter, Erik; Jensen, Winnie; Yoshida, Ken; Hoehl, Dirk; Thomas, Uwe; Kindlundh, Maria G; Norlin, Peter; de Curtis, Marco

    2006-08-01

    Multisite recording represents a suitable condition to study microphysiology and network interactions in the central nervous system and, therefore, to understand brain functions. Several different materials and array configurations have been proposed for the development of new probes utilized to record brain activity from experimental animal models. We describe new multisite silicon probes that broaden the currently available application base for neuroscientists. The array arrangement of the probes recording sites was extended to increase their spatial resolution. Probes were integrated with a newly developed electronic hardware and novel software for advanced real-time processing and analysis. The new system, based on 32- and 64-electrode silicon probes, proved very valuable to record field potentials and single unit activity from the olfactory-limbic cortex of the in vitro isolated guinea-pig brain preparation and to acutely record unit activity at multiple sites from the cerebellar cortex in vivo. The potential advantages of the new system in comparison to the currently available technology are discussed.

  9. Size effects on the open probability of two-state ion channel system in cell membranes using microcanonical formalism based on gamma function

    NASA Astrophysics Data System (ADS)

    Erdem, Riza; Aydiner, Ekrem

    2016-08-01

    Ion channel systems are a class of proteins that reside in the membranes of all biological cells and forms conduction pores that regulate the transport of ions into and out of cells. They can be investigated theoretically in the microcanonical formalism since the number of accessible states can be easily evaluated by using the Stirling approximation to deal with factorials. In this work, we have used gamma function (Γ (n)) to solve the two-state or open-close channel model without any approximation. New values are calculated for the open probability (p0) and the relative error between our numerical results and the approximate one using Stirling formula is presented. This error (p0 app — p0)/p0 is significant for small channel systems.

  10. Cascading blockages in channel bundles.

    PubMed

    Barré, C; Talbot, J

    2015-11-01

    Flow in channel networks may involve a redistribution of flux following the blockage or failure of an individual link. Here we consider a simplified model consisting of N(c) parallel channels conveying a particulate flux. Particles enter these channels according to a homogeneous Poisson process and an individual channel blocks if more than N particles are simultaneously present. The behavior of the composite system depends strongly on how the flux of entering particles is redistributed following a blockage. We consider two cases. In the first, the intensity on each open channel remains constant while in the second the total intensity is evenly redistributed over the open channels. We obtain exact results for arbitrary N(c) and N for a system of independent channels and for arbitrary N(c) and N=1 for coupled channels. For N>1 we present approximate analytical as well as numerical results. Independent channels block at a decreasing rate due to a simple combinatorial effect, while for coupled channels the interval between successive blockages remains constant for N=1 but decreases for N>1. This accelerating cascade is due to the nonlinear dependence of the mean blocking time of a single channel on the entering particle flux that more than compensates for the decrease in the number of active channels.

  11. A new channel for the formation of hydrogen cyanide in CH2-N2 systems

    NASA Technical Reports Server (NTRS)

    Laufer, A. H.; Bass, A. M.

    1978-01-01

    The reaction between N2 and either the singlet or the triplet electronic state of CH2 is investigated in order to shed light on the formation of NO in fuel-rich hydrocarbon flames. For the reaction of N2 and the triplet CH2, a rate constant less than or equal to 10 to the minus 16th power cu cm/molecule-sec is obtained. The time history of hydrogen cyanide production from the CH2-N2 systems is discussed as a basis for understanding the possible reaction routes from HCN to NO.

  12. A new computer-controlled multi-channel high voltage supply system for GRACE instrumentation

    NASA Astrophysics Data System (ADS)

    Manna, A.; Chakrabarti, S.; Mukhopadhayay, P. K.

    2002-03-01

    The high energy gamma ray telescopes being set up by the Bhabha Atomic Research Institute Centre (BARC) at Mt. Abu, Rajasthan, as part of the GRACE project, require a very large number (~ 1000) of programmable high voltage power supplies for biasing photomultiplier tubes for the detection and characterization of the atmospheric Cerenkov events. These HV supplies need to be very compact, lightweight and rugged, as they will be mounted on the base of the moving telescope. This paper describes the design aspects of the overall HV system and the performance of the prototype HV modules developed for such applications. In the new design, the inverter switching frequency of the HV supplies has been increased threefold as compared to the earlier design, and surface mounted devices have been used to achieve overall size and weight reductions. The system consists of multiple HV modules, each containing 16 independently programmable HV supplies. Each HV module has an on-board micro-controller for doing control and supervisory functions and is interconnected via a serial 12C bus. The HV supplies have built in over voltage/current, thermal overload protections with output voltage readback and adjustable slew rate control facilities.

  13. A multi-channel monolithic Ge detector system for fluorescence x-ray absorption spectroscopy

    SciTech Connect

    Bucher, J.J.; Allen, P.G.; Edelstein, N.M.; Shuh, D.K.; Madden, N.W.; Cork, C.; Luke, P.; Pehl, D.; Malone, D.

    1995-03-01

    Construction and performance of a monolithic quad-pixel Ge detector for fluorescence x-ray absorption spectroscopy (XAS) at synchrotron radiation sources are described. The detector semiconductor element has an active surface area of 4.0 cm{sup 2} which is electrically separated into four 1.0 cm{sup 2} pixels, with little interfacial dead volume. Spatial response of the array shows that cross-talk between adjacent pixels is < 10% for 5.9 keV photons that fall within 0.5 mm of the pixel boundaries. The detector electronics system uses pre-amplifiers built at LBNL with commercial Tennelec Model TC 244 amplifiers. Using an {sup 55}Fe test source (MnK{sub {alpha}}, 5.9 keV), energy resolution of better than 200 eV is achieved with a 4 {mu}sec peaking time. At 0.5 {mu}sec peaking time, pulse pileup results in a 75% throughput efficiency for an incoming count rate of 100 kHz. Initial XAS fluoresncece measurements at the beamline 4 wiggler end stations at SSRL show that the detector system has several advantages over commercial x-ray spectrometers for low-concentration counting.

  14. Adaptive selective relaying in cooperative free-space optical systems over atmospheric turbulence and misalignment fading channels.

    PubMed

    Boluda-Ruiz, Rubén; García-Zambrana, Antonio; Castillo-Vázquez, Carmen; Castillo-Vázquez, Beatriz

    2014-06-30

    In this paper, a novel adaptive cooperative protocol with multiple relays using detect-and-forward (DF) over atmospheric turbulence channels with pointing errors is proposed. The adaptive DF cooperative protocol here analyzed is based on the selection of the optical path, source-destination or different source-relay links, with a greater value of fading gain or irradiance, maintaining a high diversity order. Closed-form asymptotic bit error-rate (BER) expressions are obtained for a cooperative free-space optical (FSO) communication system with Nr relays, when the irradiance of the transmitted optical beam is susceptible to either a wide range of turbulence conditions, following a gamma-gamma distribution of parameters α and β, or pointing errors, following a misalignment fading model where the effect of beam width, detector size and jitter variance is considered. A greater robustness for different link distances and pointing errors is corroborated by the obtained results if compared with similar cooperative schemes or equivalent multiple-input multiple-output (MIMO) systems. Simulation results are further demonstrated to confirm the accuracy and usefulness of the derived results. PMID:24977911

  15. Modeling the Effectiveness of a Storm Surge Barrier System for the Houston Ship Channel during Hurricane Events

    NASA Astrophysics Data System (ADS)

    Torres, J.; Fang, N.; Bedient, P. B.; Christian, J.

    2013-12-01

    The Houston Ship Channel (HSC) is home to the second-busiest port in the nation in terms of overall tonnage, and contains one of the largest petrochemical complexes in the world. As such, undisturbed operations of the HSC are vital to ensuring the economic prosperity of local, state, and national interests. History has proven that coastal infrastructure systems and operations at the HSC are easily disrupted by rainfall and storm surge from intense hurricanes (e.g. Hurricane Ike). To quantitatively evaluate flood and storm surge vulnerability, a coupled riverine-coastal hydraulic model is developed for the HSC and Galveston Bay as an initial testbed for simulating extreme flooding scenarios. A numerical investigation is made on the coupled interactions of upstream watershed runoff and downstream surge level occurrences, as well as the effectiveness of a proposed storm surge gate protecting inland HSC infrastructure during a simulated Hurricane Ike event, and associated Ike variations. Sensitivities in peak stage, instantaneous flow, and relative timing of these events are explored for Hurricane Ike rainfall-surge conditions and various perturbations related thereto. Results show that a surge gate system can be effective to reduce flood elevation and floodplain extent in the HSC area, but that net flood protection is largely dependent on the varied timings on the watershed rainfall-runoff and coastal surge dynamics.

  16. Adaptive selective relaying in cooperative free-space optical systems over atmospheric turbulence and misalignment fading channels.

    PubMed

    Boluda-Ruiz, Rubén; García-Zambrana, Antonio; Castillo-Vázquez, Carmen; Castillo-Vázquez, Beatriz

    2014-06-30

    In this paper, a novel adaptive cooperative protocol with multiple relays using detect-and-forward (DF) over atmospheric turbulence channels with pointing errors is proposed. The adaptive DF cooperative protocol here analyzed is based on the selection of the optical path, source-destination or different source-relay links, with a greater value of fading gain or irradiance, maintaining a high diversity order. Closed-form asymptotic bit error-rate (BER) expressions are obtained for a cooperative free-space optical (FSO) communication system with Nr relays, when the irradiance of the transmitted optical beam is susceptible to either a wide range of turbulence conditions, following a gamma-gamma distribution of parameters α and β, or pointing errors, following a misalignment fading model where the effect of beam width, detector size and jitter variance is considered. A greater robustness for different link distances and pointing errors is corroborated by the obtained results if compared with similar cooperative schemes or equivalent multiple-input multiple-output (MIMO) systems. Simulation results are further demonstrated to confirm the accuracy and usefulness of the derived results.

  17. Biomedical engineering meets acupuncture - development of a miniaturized 48-channel skin impedance measurement system for needle and laser acupuncture

    PubMed Central

    2010-01-01

    Background Due to controversially discussed results in scientific literature concerning changes of electrical skin impedance before and during acupuncture a new measurement system has been developed. Methods The prototype measures and analyzes the electrical skin impedance computer-based and simultaneously in 48 channels within a 2.5×3.5 cm matrix. Preliminary measurements in one person were performed using metal needle and violet laser (405 nm) acupuncture at the acupoint Kongzui (LU6). The new system is an improvement on devices previously developed by other researchers for this purpose. Results Skin impedance in the immediate surroundings of the acupoint was lowered reproducibly following needle stimulation and also violet laser stimulation. Conclusions A new instrumentation for skin impedance measurements is presented. The following hypotheses suggested by our results will have to be tested in further studies: Needle acupuncture causes significant, specific local changes of electrical skin impedance parameters. Optical stimulation (violet laser) at an acupoint causes direct electrical biosignal changes. PMID:21092296

  18. Mu-28: an open-framework fluorogallophosphate with a three-dimensional 12-membered ring channel system

    SciTech Connect

    Josien, Ludovic; Simon-Masseron, Angelique . E-mail: a.simon@univ-mulhouse.fr; Gramlich, Volker; Porcher, Florence; Patarin, Jogl

    2004-10-01

    A new three-dimensional (3-D) microporous fluorogallophosphate, named Mu-28, was obtained by hydrothermal synthesis. It was obtained in the presence of fluoride ions with 1,4-dimethylpiperazine as organic template. This new fluorogallophosphate, with chemical formula [Ga{sub 20}P{sub 20}O{sub 80}(OH){sub 6}F{sub 6}(H{sub 2}O){sub 4}(C{sub 6}H{sub 16}N{sub 2}){sub 6}] 8H{sub 2}O, crystallizes in the monoclinic system space group P2{sub 1} with the following unit cell parameters: a=13.23(1)A, b=15.40(1)A, c=14.80(1)A, {beta}=95.10(9){sup o} (Z=1, R1=0.0435 [I>2{sigma}(I)]). Its structure was determined by single-crystal X-ray diffraction with the help of {sup 31}P NMR spectroscopy. Mu-28 consists of a complex arrangement of GaO{sub 3}(OH,F)(H{sub 2}O){sub 2}, GaO{sub 4}(OH)F and GaO{sub 4}(OH){sub 2} octahedra, GaO{sub 4}F trigonal bipyramids and GaO{sub 3}(OH,F) and PO{sub 4} tetrahedra. It displays a 3-D channel system delimited by 12-membered ring openings.

  19. Analysis of fading in the propagation channel for the ORCA laser communication system

    NASA Astrophysics Data System (ADS)

    Sauer, Paul R.; Phillips, Ronald L.; Andrews, Larry C.; Wayne, David T.; Leclerc, Troy T.

    2011-06-01

    Irradiance data were collected over an air-to-ground path using several different sized receiving apertures. The data were collected from the Optical RF Communications Adjunct (ORCA) tracking beacon. The receiver system consisted of three telescopes of sizes 51 mm, 137 mm, and 272 mm. Probability of fade, number of fades per second, and mean fade time was computed for various intensity levels for irradiance data collected on all three telescopes. These measured statistics are compared to fading models derived from lognormal and gamma-gamma probability density function (PDF) models. Discussion is centered on the viability of these models under various conditions and on the presence of aero-optic effects. The gamma-gamma and lognormal model are found to be insufficient to model all fading statistics.

  20. Average BER of subcarrier intensity modulated free space optical systems over the exponentiated Weibull fading channels.

    PubMed

    Wang, Ping; Zhang, Lu; Guo, Lixin; Huang, Feng; Shang, Tao; Wang, Ranran; Yang, Yintang

    2014-08-25

    The average bit error rate (BER) for binary phase-shift keying (BPSK) modulation in free-space optical (FSO) links over turbulence atmosphere modeled by the exponentiated Weibull (EW) distribution is investigated in detail. The effects of aperture averaging on the average BERs for BPSK modulation under weak-to-strong turbulence conditions are studied. The average BERs of EW distribution are compared with Lognormal (LN) and Gamma-Gamma (GG) distributions in weak and strong turbulence atmosphere, respectively. The outage probability is also obtained for different turbulence strengths and receiver aperture sizes. The analytical results deduced by the generalized Gauss-Laguerre quadrature rule are verified by the Monte Carlo simulation. This work is helpful for the design of receivers for FSO communication systems.

  1. A Study of Planetary System Formation and Evolution Using a Dual Channel Adaptive Optics Imaging Polarimeter

    NASA Technical Reports Server (NTRS)

    Potter, Daniel E.

    2003-01-01

    The award I received from the Graduate Student Research Program in 2001, and the renewal award in 2002, supported the gathering and processing of my thesis data, and the presentation of my scientific results at astronomy conferences. Ultimately, this led to a successful defense of my PhD thesis. In the thesis work, I built, calibrated, and observed with the first dual imaging polarimeter ever used in series with a high order adaptive optics system and on an 8 meter class telescope. The instrument was arguably the most sensitive instrument for the high-contrast detection of the scattered light from circumstellar disks. The success of the instrument has provided the impetus for the construction of several similar simultaneous adaptive optics imaging polarimeters. In the course of the observations, a number of circumstellar disks were resolved for the first time in their scattered light, such as the disk around the classical T-tauri stars, LkCa 15 and LkHa 262. A sample of 24 young, nearby, solar-analog stars were observed with the instrument in search of the scattered light signature from debris disks around these stars. Although none of the stars revealed any obvious scattered light signatures, a meaningful limit was placed on the dust population around these stars. Also, a brown dwarf binary system was found to be a companion to one of the solar-analog stars observed, HD130948. A careful monitoring of the orbit of the binary brown dwarf will result in a dynamical mass determination of the objects, providing a valuable calibration of the physical models explaining brown dwarf evolution.

  2. Accuracy of acoustic velocity metering systems for measurement of low velocity in open channels

    USGS Publications Warehouse

    Laenen, Antonius; Curtis, R.E.

    1989-01-01

    Acoustic velocity meter (AVM) accuracy depends on equipment limitations, the accuracy of acoustic-path length and angle determination, and the stability of the mean velocity to acoustic-path velocity relation. Equipment limitations depend on path length and angle, transducer frequency, timing oscillator frequency, and signal-detection scheme. Typically, the velocity error from this source is about +or-1 to +or-10 mms/sec. Error in acoustic-path angle or length will result in a proportional measurement bias. Typically, an angle error of one degree will result in a velocity error of 2%, and a path-length error of one meter in 100 meter will result in an error of 1%. Ray bending (signal refraction) depends on path length and density gradients present in the stream. Any deviation from a straight acoustic path between transducer will change the unique relation between path velocity and mean velocity. These deviations will then introduce error in the mean velocity computation. Typically, for a 200-meter path length, the resultant error is less than one percent, but for a 1,000 meter path length, the error can be greater than 10%. Recent laboratory and field tests have substantiated assumptions of equipment limitations. Tow-tank tests of an AVM system with a 4.69-meter path length yielded an average standard deviation error of 9.3 mms/sec, and the field tests of an AVM system with a 20.5-meter path length yielded an average standard deviation error of a 4 mms/sec. (USGS)

  3. A modular architecture for multi-channel external cavity quantum cascade laser-based chemical sensors: a systems approach

    SciTech Connect

    Taubman, Matthew S.; Myers, Tanya L.; Bernacki, Bruce E.; Stahl, Robert D.; Cannon, Bret D.; Schiffern, John T.; Phillips, Mark C.

    2012-04-01

    A multi-channel laser-based chemical sensor platform is presented, in which a modular architecture allows the exchange of complete sensor channels without disruption to overall operation. Each sensor channel contains custom optical and electronics packages, which can be selected to access laser wavelengths, interaction path lengths and modulation techniques optimal for a given application or mission. Although intended primarily to accommodate mid-infrared (MIR) external cavity quantum cascade lasers (ECQCLs)and astigmatic Herriott cells, channels using visible or near infrared (NIR) lasers or other gas cell architectures can also be used, making this a truly versatile platform. Analog and digital resources have been carefully chosen to facilitate small footprint, rapid spectral scanning, ow-noise signal recovery, failsafe autonomous operation, and in-situ chemometric data analysis, storage and transmission. Results from the demonstration of a two-channel version of this platform are also presented.

  4. Development and application of a multi-channel monitoring system for near real-time VOC measurement in a hazardous waste management facility.

    PubMed

    Je, Chung-hwan; Stone, Richard; Oberg, Steven G

    2007-09-01

    This paper describes the development and application of a multi-channel monitoring system for recording, processing, and analyzing volatile organic compound (VOC) levels discharged to the atmosphere from a walk-in hood in a hazardous waste management facility. The monitoring system consists of an array of PID (photo ionization detector) sensors and a networked control program that provides operational schematic diagram, performs data analyses, and illustrates real-time graphical displays. Furthermore, the system records potential worker exposures, exhaust filtration efficiency and environmental release levels. Multi-channel continuous monitoring of VOCs is successfully implemented during chemical bulking operations. It is shown that a real-time monitoring system is effective for early warning detection of hazardous chemicals and for predicting the performance of adsorption filters used for VOC removal. In addition, a connected local weather visualization system supports efforts to minimize potential health and environmental impacts of VOC emissions to surrounding areas.

  5. HO + OClO Reaction System: Featuring a Barrierless Entrance Channel with Two Transition States.

    PubMed

    Yang, Lei; Sonk, Jason A; Barker, John R

    2015-06-01

    Chlorine-containing compounds play a significant role in the troposphere and are key players in the stratosphere. The free radical compound OClO reacts with HO free radicals, but the existing experimental kinetics data are limited and uncertain. In the present theoretical investigation, the reaction mechanism, rate constants, and product branching ratios for the HO + OClO reaction system were computed over wide temperature and pressure ranges and compared with the existing experimental data. Stationary points on the singlet potential energy surface (PES) were calculated at high levels of theory, and the kinetics parameters were computed using several methods, including variational transition state theory (VTST) and RRKM/master equation techniques. The computed PES is in reasonable agreement with previous calculations, and the computed rate constants and branching ratio are in good agreement with the recent experiments. The results are used as the basis for recommendations for atmospheric chemistry modeling. The PES along the reaction path forming the peroxy bond has a steplike structure and only a very weakly bound prereactive complex, and yet it still supports two transition states along the reaction path. This feature may also be present in other reactions in which electrostatic forces align the approaching reactants in an unfavorable orientation at long distances, thus requiring a dramatic geometry change before reaction can take place. PMID:25942406

  6. Effect of stocking large channel catfish in a biofloc technology production system on production and incidence of common microbial off-flavor compounds

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Density-dependent production and incidence of common microbial off-flavors caused by geosmin and 2-methylisoborneol were investigated in an outdoor biofloc technology production system stocked with stocker-size (217 g/fish) channel catfish at 1.4, 2.1, or 2.8 kg/m3. Individual weight at harvest rang...

  7. Low noise multi-channel biopotential wireless data acquisition system for dry electrodes

    NASA Astrophysics Data System (ADS)

    Pandian, P. S.; Whitchurch, Ashwin K.; Abraham, Jose K.; Bhusan Baskey, Himanshu; Radhakrishnan, J. K.; Varadan, Vijay K.; Padaki, V. C.; Bhasker Rao, K. U.; Harbaugh, R. E.

    2008-03-01

    The bioelectrical potentials generated within the human body are the result of electrochemical activity in the excitable cells of the nervous, muscular or glandular tissues. The ionic potentials are measured using biopotential electrodes which convert ionic potentials to electronic potentials. The commonly monitored biopotential signals are Electrocardiogram (ECG), Electroencephalogram (EEG) and Electromyogram (EMG). The electrodes used to monitor biopotential signals are Ag-AgCl and gold, which require skin preparation by means of scrubbing to remove the dead cells and application of electrolytic gel to reduce the skin contact resistance. The gels used in biopotential recordings dry out when used for longer durations and add noise to the signals and also prolonged use of gels cause irritations and rashes to skin. Also noises such as motion artifact and baseline wander are added to the biopotential signals as the electrode floats over the electrolytic gel during monitoring. To overcome these drawbacks, dry electrodes are used, where the electrodes are held against the skin surface to establish contact with the skin without the need for electrolytic fluids or gels. The major drawback associated with the dry electrodes is the high skin-electrode impedance in the low frequency range between 0.1-120 Hz, which makes it difficult to acquire clean and noise free biopotential signals. The paper presents the design and development of biopotential data acquisition and processing system to acquire biopotential signals from dry electrodes. The electrode-skin-electrode- impedance (ESEI) measurements was carried out for the dry electrodes by impedance spectroscopy. The biopotential signals are processed using an instrumentation amplifier with high CMRR and high input impedance achieved by boot strapping the input terminals. The signals are band limited by means of a second order Butterworth band pass filters to eliminate noise. The processed biopotential signals are digitized

  8. Performance analysis of precoding-based asymmetrically clipped optical orthogonal frequency division multiplexing wireless system in additive white Gaussian noise and indoor multipath channel

    NASA Astrophysics Data System (ADS)

    Ranjha, Bilal; Zhou, Zhou; Kavehrad, Mohsen

    2014-08-01

    We have compared the bit error rate (BER) performance of precoding-based asymmetrically clipped optical orthogonal frequency division multiplexing (ACO-OFDM) and pulse amplitude modulated discrete multitone (PAM-DMT) optical wireless (OW) systems in additive white Gaussian noise (AWGN) and indoor multipath frequency selective channel. Simulation and analytical results show that precoding schemes such as discrete Fourier transform, discrete cosine transform, and Zadoff-Chu sequences do not affect the performance of the OW systems in the AWGN channel while they do reduce the peak-to-average power ratio (PAPR) of the OFDM output signal. However, in a multipath indoor channel, using zero forcing frequency domain equalization precoding-based systems give better BER performance than their conventional counterparts. With additional clipping to further reduce the PAPR, precoding-based systems also show better BER performance compared to nonprecoded systems when clipped relative to the peak of nonprecoded systems. Therefore, precoding-based ACO-OFDM and PAM-DMT systems offer better BER performance, zero signaling overhead, and low PAPR compared to conventional systems.

  9. Influence of polarization state, baud rate and PMD on non-linear impairments in WDM systems with mixed PM (D)QPSK and OOK channels.

    PubMed

    Chughtai, Mohsan Niaz; Forzati, Marco; Mårtensson, Jonas; Rafique, Danish

    2012-03-26

    In this paper we numerically investigate nonlinear impairments in a WDM system with mixed PM (D)QPSK and OOK channels. First we analyze the dependence of XPM and XPolM on SOP and baud rate in absence of PMD. In this case we find that the nonlinear impairments are highly dependent on relative SOP between the PM (D)QPSK and neighbouring OOK channels. The dependence on relative SOP is more pronounced in differential detection than in coherent detection. However, with increasing values of PMD this dependence decreases, and non-linear tolerance improves.

  10. A ROS-Assisted Calcium Wave Dependent on the AtRBOHD NADPH Oxidase and TPC1 Cation Channel Propagates the Systemic Response to Salt Stress.

    PubMed

    Evans, Matthew J; Choi, Won-Gyu; Gilroy, Simon; Morris, Richard J

    2016-07-01

    Plants exhibit rapid, systemic signaling systems that allow them to coordinate physiological and developmental responses throughout the plant body, even to highly localized and quickly changing environmental stresses. The propagation of these signals is thought to include processes ranging from electrical and hydraulic networks to waves of reactive oxygen species (ROS) and cytoplasmic Ca(2+) traveling throughout the plant. For the Ca(2+) wave system, the involvement of the vacuolar ion channel TWO PORE CHANNEL1 (TPC1) has been reported. However, the precise role of this channel and the mechanism of cell-to-cell propagation of the wave have remained largely undefined. Here, we use the fire-diffuse-fire model to analyze the behavior of a Ca(2+) wave originating from Ca(2+) release involving the TPC1 channel in Arabidopsis (Arabidopsis thaliana). We conclude that a Ca(2+) diffusion-dominated calcium-induced calcium-release mechanism is insufficient to explain the observed wave transmission speeds. The addition of a ROS-triggered element, however, is able to quantitatively reproduce the observed transmission characteristics. The treatment of roots with the ROS scavenger ascorbate and the NADPH oxidase inhibitor diphenyliodonium and analysis of Ca(2+) wave propagation in the Arabidopsis respiratory burst oxidase homolog D (AtrbohD) knockout background all led to reductions in Ca(2+) wave transmission speeds consistent with this model. Furthermore, imaging of extracellular ROS production revealed a systemic spread of ROS release that is dependent on both AtRBOHD and TPC1 These results suggest that, in the root, plant systemic signaling is supported by a ROS-assisted calcium-induced calcium-release mechanism intimately involving ROS production by AtRBOHD and Ca(2+) release dependent on the vacuolar channel TPC1. PMID:27261066

  11. A ROS-Assisted Calcium Wave Dependent on the AtRBOHD NADPH Oxidase and TPC1 Cation Channel Propagates the Systemic Response to Salt Stress1[OPEN

    PubMed Central

    Evans, Matthew J.; Choi, Won-Gyu

    2016-01-01

    Plants exhibit rapid, systemic signaling systems that allow them to coordinate physiological and developmental responses throughout the plant body, even to highly localized and quickly changing environmental stresses. The propagation of these signals is thought to include processes ranging from electrical and hydraulic networks to waves of reactive oxygen species (ROS) and cytoplasmic Ca2+ traveling throughout the plant. For the Ca2+ wave system, the involvement of the vacuolar ion channel TWO PORE CHANNEL1 (TPC1) has been reported. However, the precise role of this channel and the mechanism of cell-to-cell propagation of the wave have remained largely undefined. Here, we use the fire-diffuse-fire model to analyze the behavior of a Ca2+ wave originating from Ca2+ release involving the TPC1 channel in Arabidopsis (Arabidopsis thaliana). We conclude that a Ca2+ diffusion-dominated calcium-induced calcium-release mechanism is insufficient to explain the observed wave transmission speeds. The addition of a ROS-triggered element, however, is able to quantitatively reproduce the observed transmission characteristics. The treatment of roots with the ROS scavenger ascorbate and the NADPH oxidase inhibitor diphenyliodonium and analysis of Ca2+ wave propagation in the Arabidopsis respiratory burst oxidase homolog D (AtrbohD) knockout background all led to reductions in Ca2+ wave transmission speeds consistent with this model. Furthermore, imaging of extracellular ROS production revealed a systemic spread of ROS release that is dependent on both AtRBOHD and TPC1. These results suggest that, in the root, plant systemic signaling is supported by a ROS-assisted calcium-induced calcium-release mechanism intimately involving ROS production by AtRBOHD and Ca2+ release dependent on the vacuolar channel TPC1. PMID:27261066

  12. Channel in Kasei

    NASA Technical Reports Server (NTRS)

    2004-01-01

    14 November 2004 The Kasei Valles are a suite of very large, ancient outflow channels. This Mars Global Surveyor (MGS) Mars Orbiter Camera (MOC) image shows a portion of the youngest channel system in the Kasei Valles. Torrents of mud, rocks, and water carved this channel as flow was constricted through a narrow portion of the valley. Layers exposed by the erosion that created the channel can be seen in its walls. This 1.4 meters (5 feet) per pixel image is located near 21.1oN, 72.6oW. The picture covers an area approximately 3 km (1.9 mi) across. Sunlight illuminates the scene from the lower left.

  13. Adaptive neuro-fuzzy inference system for acoustic analysis of 4-channel phonocardiograms using empirical mode decomposition.

    PubMed

    Becerra, Miguel A; Orrego, Diana A; Delgado-Trejos, Edilson

    2013-01-01

    The heart's mechanical activity can be appraised by auscultation recordings, taken from the 4-Standard Auscultation Areas (4-SAA), one for each cardiac valve, as there are invisible murmurs when a single area is examined. This paper presents an effective approach for cardiac murmur detection based on adaptive neuro-fuzzy inference systems (ANFIS) over acoustic representations derived from Empirical Mode Decomposition (EMD) and Hilbert-Huang Transform (HHT) of 4-channel phonocardiograms (4-PCG). The 4-PCG database belongs to the National University of Colombia. Mel-Frequency Cepstral Coefficients (MFCC) and statistical moments of HHT were estimated on the combination of different intrinsic mode functions (IMFs). A fuzzy-rough feature selection (FRFS) was applied in order to reduce complexity. An ANFIS network was implemented on the feature space, randomly initialized, adjusted using heuristic rules and trained using a hybrid learning algorithm made up by least squares and gradient descent. Global classification for 4-SAA was around 98.9% with satisfactory sensitivity and specificity, using a 50-fold cross-validation procedure (70/30 split). The representation capability of the EMD technique applied to 4-PCG and the neuro-fuzzy inference of acoustic features offered a high performance to detect cardiac murmurs. PMID:24109851

  14. Adaptive neuro-fuzzy inference system for acoustic analysis of 4-channel phonocardiograms using empirical mode decomposition.

    PubMed

    Becerra, Miguel A; Orrego, Diana A; Delgado-Trejos, Edilson

    2013-01-01

    The heart's mechanical activity can be appraised by auscultation recordings, taken from the 4-Standard Auscultation Areas (4-SAA), one for each cardiac valve, as there are invisible murmurs when a single area is examined. This paper presents an effective approach for cardiac murmur detection based on adaptive neuro-fuzzy inference systems (ANFIS) over acoustic representations derived from Empirical Mode Decomposition (EMD) and Hilbert-Huang Transform (HHT) of 4-channel phonocardiograms (4-PCG). The 4-PCG database belongs to the National University of Colombia. Mel-Frequency Cepstral Coefficients (MFCC) and statistical moments of HHT were estimated on the combination of different intrinsic mode functions (IMFs). A fuzzy-rough feature selection (FRFS) was applied in order to reduce complexity. An ANFIS network was implemented on the feature space, randomly initialized, adjusted using heuristic rules and trained using a hybrid learning algorithm made up by least squares and gradient descent. Global classification for 4-SAA was around 98.9% with satisfactory sensitivity and specificity, using a 50-fold cross-validation procedure (70/30 split). The representation capability of the EMD technique applied to 4-PCG and the neuro-fuzzy inference of acoustic features offered a high performance to detect cardiac murmurs.

  15. Fast imaging readout and electronics—a novel high-speed imaging system for micro-channel plates

    NASA Astrophysics Data System (ADS)

    Lapington, J. S.; Rees, K.

    2002-01-01

    The band-width of charge division readout anodes used with micro-channel plates (MCP) is usually limited by the speed of the acquisition electronics. We present a novel charge division anode that does not require analogue to digital conversion. The Fast Imaging Readout and Electronics is a new concept in high-speed imaging using an MCP detector. The imaging system described comprises an MCP intensifier coupled to a charge division image readout using high-speed, multichannel electronics. It has a projected spatial resolution of up to 128×128 pixels, though the image format is inherently flexible, and the potential for rates up to 100 million events per second with nanosecond timing resolution. The readout pattern has a planar electrode structure and the collected charge from each event is shared amongst all electrodes, grouped in pairs. The unique design of the readout obviates the need for charge measurement, usually the dominant process determining the event-processing deadtime. Instead, high-speed signal comparators, each of which act on the signals from an electrode pair, are used to define a binary code from which the position co-ordinate is directly mapped. We describe a proof of the concept of prototype anode and associated electronics using a novel application of very high-speed digital circuitry. We present preliminary results showing signal waveforms measured using a one-dimensional 16-pixel anode pattern.

  16. Measurements and coupled reaction channels analysis of one and two proton transfer reactions for 28Si+90,94Zr systems

    NASA Astrophysics Data System (ADS)

    Kalkal, Sunil; Mandal, S.; Jhingan, A.; Gehlot, J.; Sugathan, P.; Golda, K. S.; Madhavan, N.; Garg, Ritika; Goyal, Savi; Mohanto, Gayatri; Verma, S.; Sandal, Rohit; Behera, Bivash; Eleonora, G.; Wollersheim, H. J.; Singh, R.

    2011-10-01

    Measurements of angular distributions for one and two proton stripping reactions for 28Si+90,94Zr systems were performed at lab energy 120 MeV with 28Si beam at Inter University Accelerator Center, New Delhi. Theoretical calculations performed using the quantum mechanical coupled reaction channels code FRESCO (including various intermediate states involving target and projectile excitations before and/or after transfer along with sequential transfer) were able to reproduce one and two proton transfer angular distributions for both the systems reasonably well. It was found that the DWBA calculations could describe the one proton transfer data well for both the systems but failed to reproduce the angular distributions for two proton transfer channels. The present measurements underline the importance of sequential transfer at energies much above the Coulomb barrier. We had also performed transfer reaction measurements for these systems in the sub- and near barrier region using recoil mass separator.

  17. Cloning and expression of ligand-gated ion-channel receptor L2 in central nervous system

    SciTech Connect

    Houtani, Takeshi; Munemoto, Yumi; Kase, Masahiko; Sakuma, Satoru; Tsutsumi, Toshiyuki; Sugimoto, Tetsuo . E-mail: sugimoto@takii.kmu.ac.jp

    2005-09-23

    An orphan receptor of ligand-gated ion-channel type (L2, also termed ZAC according to the presence of zinc ion for channel activation) was identified by computer-assisted search programs on human genome database. The L2 protein shares partial homology with serotonin receptors 5HT3A and 5HT3B. We have cloned L2 cDNA derived from human caudate nucleus and characterized the exon-intron structure as follows: (1) The L2 protein has four transmembrane regions (M1-M4) and a long cytoplasmic loop between M3 and M4. (2) The sequence is conserved in species including chimpanzee, dog, cow, and opossum. (3) Nine exons form its protein-coding region and especially exon 5 corresponds to a disulfide bond region on the amino-terminal side. Our analysis using multiple tissue cDNA panels revealed that at least two splicing variants of L2 mRNA are present. The cDNA PCR amplification study revealed that L2 mRNA is expressed in tissues including brain, pancreas, liver, lung, heart, kidney, and skeletal muscle while 5HT3A mRNA could be detected in brain, heart, placenta, lung, kidney, pancreas, and skeletal muscle, and 5HT3B mRNA in brain, kidney, and skeletal muscle, suggesting different significance in tissue expression of these receptors. Regional expression of L2 mRNA and protein was examined in brain. The RT-PCR studies confirmed L2 mRNA expression in hippocampus, striatum, amygdala, and thalamus in adult brain. The L2 protein was immunolocalized by using antipeptide antibodies. Immunostained tissue sections revealed that L2-like immunoreactivity was dominantly expressed in the hippocampal CA3 pyramidal cells and in the polymorphic layer of the dentate gyrus. We analyzed the expression of L2 protein in HEK293 cells using GFP fusion protein reporter system. Western blots revealed that L2 protein confers sugar chains on the extracellular side. In transfected HEK293 cells, cellular membranes and intracellular puncta were densely labeled with GFP, suggesting selective dispatch to the

  18. English Channel

    NASA Technical Reports Server (NTRS)

    1984-01-01

    The cloud covered earthscape of Northern Europe demonstrates the difficulty of photographing this elusive subject from space. The English Channel (51.0N, 1.5E) separating the British Islands from Europe is in the center of the scene. The white cliffs of Dover on the SE coast of the UK, the Thames River estuary and a partial view of the city of London can be seen on the north side of the Channel while the Normandy coast of France is to the south.

  19. Investigating the Performance of One- and Two-dimensional Flood Models in a Channelized River Network: A Case Study of the Obion River System

    NASA Astrophysics Data System (ADS)

    Kalyanapu, A. J.; Dullo, T. T.; Thornton, J. C.; Auld, L. A.

    2015-12-01

    Obion River, is located in the northwestern Tennessee region, and discharges into the Mississippi River. In the past, the river system was largely channelized for agricultural purposes that resulted in increased erosion, loss of wildlife habitat and downstream flood risks. These impacts are now being slowly reversed mainly due to wetland restoration. The river system is characterized by a large network of "loops" around the main channels that hold water either from excess flows or due to flow diversions. Without data on each individual channel, levee, canal, or pond it is not known where the water flows from or to. In some segments along the river, the natural channel has been altered and rerouted by the farmers for their irrigation purposes. Satellite imagery can aid in identifying these features, but its spatial coverage is temporally sparse. All the alterations that have been done to the watershed make it difficult to develop hydraulic models, which could predict flooding and droughts. This is especially true when building one-dimensional (1D) hydraulic models compared to two-dimensional (2D) models, as the former cannot adequately simulate lateral flows in the floodplain and in complex terrains. The objective of this study therefore is to study the performance of 1D and 2D flood models in this complex river system, evaluate the limitations of 1D models and highlight the advantages of 2D models. The study presents the application of HEC-RAS and HEC-2D models developed by the Hydrologic Engineering Center (HEC), a division of the US Army Corps of Engineers. The broader impacts of this study is the development of best practices for developing flood models in channelized river systems and in agricultural watersheds.

  20. Dequantization Via Quantum Channels

    NASA Astrophysics Data System (ADS)

    Andersson, Andreas

    2016-08-01

    For a unital completely positive map {Φ} ("quantum channel") governing the time propagation of a quantum system, the Stinespring representation gives an enlarged system evolving unitarily. We argue that the Stinespring representations of each power {Φ^m} of the single map together encode the structure of the original quantum channel and provide an interaction-dependent model for the bath. The same bath model gives a "classical limit" at infinite time {mto∞} in the form of a noncommutative "manifold" determined by the channel. In this way, a simplified analysis of the system can be performed by making the large-m approximation. These constructions are based on a noncommutative generalization of Berezin quantization. The latter is shown to involve very fundamental aspects of quantum-information theory, which are thereby put in a completely new light.