An analysis of equine round pen training videos posted online: Differences between amateur and professional trainers.

PubMed

Kydd, Erin; Padalino, Barbara; Henshall, Cathrynne; McGreevy, Paul

2017-01-01

Natural Horsemanship is popular among many amateur and professional trainers and as such, has been the subject of recent scientific enquiry. One method commonly adopted by Natural Horsemanship (NH) trainers is that of round pen training (RPT). RPT sessions are usually split into a series of bouts; each including two phases: chasing/flight and chasing offset/flight offset. However, NH training styles are heterogeneous. This study investigated online videos of RPT to explore the characteristics of RPT sessions and test for differences in techniques and outcomes between amateurs and professionals (the latter being defined as those with accompanying online materials that promote clinics, merchandise or a service to the public). From more than 300 candidate videos, we selected sample files for individual amateur (n = 24) and professional (n = 21) trainers. Inclusion criteria were: training at liberty in a Round Pen; more than one bout and good quality video. Sessions or portions of sessions were excluded if the trainer attached equipment, such as a lunge line, directly to the horse or the horse was saddled, mounted or ridden. The number of bouts and duration of each chasing and non-chasing phase were recorded, and the duration of each RPT session was calculated. General weighted regression analysis revealed that, when compared with amateurs, professionals showed fewer arm movements per bout (p<0.05). Poisson regression analysis showed that professionals spent more time looking up at their horses, when transitioning between gaits, than amateurs did (p<0.05). The probability of horses following the trainer was not significantly associated with amount of chasing, regardless of category. Given that, according to some practitioners, the following response is a goal of RPT, this result may prompt caution in those inclined to give chase. The horses handled by professionals showed fewer conflict behaviours (e.g. kicking, biting, stomping, head-tossing, defecating, bucking and attempting to escape), and fewer oral and head movements (e.g. head-lowering, licking and chewing) than those horses handled by amateurs Overall, these findings highlight the need for selectivity when using the internet as an educational source and the importance of trainer skill and excellent timing when using negative reinforcement in horse training.

Into the Fray: How a Funders Coalition Restored Momentum for Early Learning in Minnesota. FCD Case Study

ERIC Educational Resources Information Center

Hage, Dave

2012-01-01

In the fall of 2008, a coalition of Minnesota foundations commissioned a local research organization to assess the state's ability to undertake a major improvement in school readiness and early learning services for disadvantaged children. The findings were discouraging. Richard Chase, working at the research arm of St. Paul's Amherst H. Wilder…

Tornado chasing: an introduction to risk tourism opportunities

Treesearch

Heather Cantillon; Robert S. Bristow

2001-01-01

Tours devoted to tornado storm chasing have become popular in recent years, especially with the emergence of many profit and non-profit storm chasing organizations. While most literature in risk recreation has been directed toward rock climbing or other high-risk outdoor recreation activities, tours devoted to storm chasing are quite unlike these traditional activities...

An application of importance-performance analysis to recreational storm chasing

Treesearch

Jiawen Chen; Sonja Wilhelm Stanis; Carla Barbieri; Shuangyu Xu

2012-01-01

Since the release of the movie "Twister" in 1996, storm chasing has become an increasingly popular form of recreation. Storm chasing tour agencies have emerged to provide technical assistance and guidance to individuals wishing to participate in this activity. However, little is known about the participants' perceptions of their storm chasing tours....

75 FR 31510 - Fox Chase Bancorp, Inc., Hatboro, PA; Approval of Conversion

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-03

... DEPARTMENT OF THE TREASURY Office of Thrift Supervision [AC-43: OTS No. H-4707] Fox Chase Bancorp, Inc., Hatboro, PA; Approval of Conversion Application Notice is hereby given that on May 14, 2010, the Office of Thrift Supervision approved the application of Fox Chase MHC and Fox Chase Bank, Hatboro...

Solution or suspension - Does it matter for lipid based systems? In vivo studies of chase dosing lipid vehicles with aqueous suspensions of a poorly soluble drug.

PubMed

Larsen, A T; Holm, R; Müllertz, A

2017-08-01

In this study, the potential of co-administering an aqueous suspension with a placebo lipid vehicle, i.e. chase dosing, was investigated in rats relative to the aqueous suspension alone or a solution of the drug in the lipid vehicle. The lipid investigated in the present study was Labrafil M2125CS and three evaluated poorly soluble model compounds, danazol, cinnarizine and halofantrine. For cinnarizine and danazol the oral bioavailability in rats after chase dosing or dosing the compound dissolved in Labrafil M21515CS was similar and significantly higher than for the aqueous suspension. For halofantrine the chase dosed group had a tendency towards a low bioavailability relative to the Labrafil M2125CS solution, but still a significant higher bioavailability relative to the aqueous suspension. This could be due to factors such as a slower dissolution rate in the intestinal phase of halofantrine or a lower solubility in the colloidal structures formed during digestion, but other mechanisms may also be involved. The study thereby supported the potential of chase dosing as a potential dosing regimen in situations where it is beneficial to have a drug in the solid state, e.g. due to chemical stability issues in the lipid vehicle. Copyright © 2017 Elsevier B.V. All rights reserved.

Motivations and sensation seeking characteristics of recreational storm chasers

Treesearch

Shuangyu Xu; Sonja Wilhelm Stanis; Carla Barbieri; Jiawen Chen

2012-01-01

Little is known about recreational storm chasing, a type of risk recreation that has increased in popularity since the 1990s. This study was conducted to understand factors associated with participation in recreational storm chasing in the United States. Particularly, this study assessed the motivations and sensation seeking attributes of recreational storm chasers, as...

The Psychophysics of Chasing: A Case Study in the Perception of Animacy

ERIC Educational Resources Information Center

Gao, Tao; Newman, George E.; Scholl, Brian J.

2009-01-01

Psychologists have long been captivated by the perception of animacy--the fact that even simple moving shapes may appear to engage in animate, intentional, and goal-directed movements. Here we report several new types of studies of a particularly salient form of perceived animacy: "chasing", in which one shape (the "wolf") pursues another shape…

Alterations in functional brain networks associated with loss-chasing in gambling disorder and cocaine-use disorder.

PubMed

Worhunsky, Patrick D; Potenza, Marc N; Rogers, Robert D

2017-09-01

Continued, persistent gambling to recover accumulating losses, or 'loss-chasing', is a behavioral pattern linked particularly closely to gambling disorder (GD) but may reflect impaired decision-making processes relevant to drug addictions like cocaine-use disorder (CUD). However, little is known regarding the neurocognitive mechanisms of this complex, maladaptive behavior, particularly in individuals with addictive disorders. Seventy participants (25 GD, 18 CUD, and 27 healthy comparison (HC)) completed a loss-chase task during fMRI. Engagement of functional brain networks in response to losing outcomes and during decision-making periods preceding choices to loss-chase or to quit chasing losses were investigated using independent component analysis (ICA). An exploratory factor analysis was performed to examine patterns of coordinated engagement across identified networks. In GD relative to HC and CUD participants, choices to quit chasing were associated with greater engagement of a medial frontal executive-processing network. By comparison, CUD participants exhibited altered engagement of a striato-amygdala motivational network in response to losing outcomes as compared to HC, and during decision-making as compared to GD. Several other networks were differentially engaged during loss-chase relative to quit-chasing choices, but did not differ across participant groups. Exploratory factor analysis identified a system of coordinated activity across prefrontal executive-control networks that was greater in GD and CUD relative to HC participants and was associated with increased chasing persistence across all participants. Results provide evidence of shared and distinct neurobiological mechanisms in substance and behavioral addictions, and lend insight into potential cognitive interventions targeting loss-chasing behavior in GD. Copyright © 2017 Elsevier B.V. All rights reserved.

Mate-finding behaviour in Calanus marshallae Frost

PubMed Central

Tsuda, A.

1998-01-01

Mate-finding behaviour by Calanus marshallae Frost, 1974, was observed and video recorded in a 1 m diameter kreisel. Newly moulted females signal to males by depositing vertical pheromone trails many tens of centimetres long. Males search for trails along primarily horizontal trajectories. The orthogonality of signal trace and search trail trajectory maximizes the chance of intersection. Males often initiate a dance of rapid, tight turns upon encountering a pheromone trail, then waggle down it (chase swimming) to the signalling female. She jumps away after initial contact, and the male follows. Many successive approach, bump and jump sequences follow, with mating eventually ensuing. The actual copulatory clasp and spermatophore transfer were not observed, although a few instances of brief attachment and tandem swimming were seen. Male dances occur at times when chase swimming does not follow, and the function of dances is not yet known.

Environmental Effects on Compulsive Tail Chasing in Dogs

PubMed Central

Tiira, Katriina; Hakosalo, Osmo; Kareinen, Lauri; Thomas, Anne; Hielm-Björkman, Anna; Escriou, Catherine; Arnold, Paul; Lohi, Hannes

2012-01-01

Obsessive Compulsive Disorder (OCD) is a neuropsychiatric disorder observed both in humans and animals. Examples of Canine Compulsive Disorder (CD) include excessive tail chasing (TC), light/shadow chasing and flank sucking. We performed a questionnaire survey to investigate the characteristics of compulsive (TC) and its possible associations with environmental correlates and personality in a pet population of 368 dogs from four dog breeds. We observed an early onset of TC at 3–6 months of age and a large variation in TC frequency in all breeds, with an overrepresentation of milder cases. Almost half of the TC dogs showed lowered responsiveness during bouts and displayed also other types of compulsions more often than the controls. Interestingly, dogs that received dietary supplements, especially vitamins and minerals, expressed less TC compared to dogs that did not receive any supplements. Neutered females had less TC, suggesting an influence of ovarian hormones on TC. Tail chasers were shyer and had separated earlier from their mothers than the controls. Finally, our genetic study did not find an association between TC and CDH2, a locus previously associated with the canine flank sucking compulsion. In conclusion, the early-onset and the variable nature of the repetitive behaviour, which is affected by environmental factors such as micronutrients, neutering and maternal care, share several similar components between canine and human compulsions and supports canine TC as a model for human OCD. PMID:22844513

Chinese Learning Journeys: Chasing the Dream

ERIC Educational Resources Information Center

Su, Feng, Ed.

2011-01-01

Eight students from mainland China chart their learning journeys across national and continental boundaries and socio-cultural contexts. The five women and three men structure their experiences of studying in China and the West around the turning points and life changing choices they made in chasing their dreams. They embody its emergent…

NASA HS3 Global Hawk on the Wing

NASA Image and Video Library

2013-08-30

The NASA Wallops T-34 chase aircraft intercepted Global Hawk 872 on its descent to runway 28 at NASA's Wallops Flight Facility in Wallops Island, Va. This photo of the Global Hawk was taken from the chase plane after finishing its third science flight. For more information about NASA's HS3 mission, visit: www.nasa.gov/HS3 Credit: NASA/ Brea Reeves NASA image use policy. NASA Goddard Space Flight Center enables NASA’s mission through four scientific endeavors: Earth Science, Heliophysics, Solar System Exploration, and Astrophysics. Goddard plays a leading role in NASA’s accomplishments by contributing compelling scientific knowledge to advance the Agency’s mission. Follow us on Twitter Like us on Facebook Find us on Instagram

Pilots' Attention Distributions Between Chasing a Moving Target and a Stationary Target.

PubMed

Li, Wen-Chin; Yu, Chung-San; Braithwaite, Graham; Greaves, Matthew

2016-12-01

Attention plays a central role in cognitive processing; ineffective attention may induce accidents in flight operations. The objective of the current research was to examine military pilots' attention distributions between chasing a moving target and a stationary target. In the current research, 37 mission-ready F-16 pilots participated. Subjects' eye movements were collected by a portable head-mounted eye-tracker during tactical training in a flight simulator. The scenarios of chasing a moving target (air-to-air) and a stationary target (air-to-surface) consist of three operational phases: searching, aiming, and lock-on to the targets. The findings demonstrated significant differences in pilots' percentage of fixation during the searching phase between air-to-air (M = 37.57, SD = 5.72) and air-to-surface (M = 33.54, SD = 4.68). Fixation duration can indicate pilots' sustained attention to the trajectory of a dynamic target during air combat maneuvers. Aiming at the stationary target resulted in larger pupil size (M = 27,105, SD = 6565), reflecting higher cognitive loading than aiming at the dynamic target (M = 23,864, SD = 8762). Pilots' visual behavior is not only closely related to attention distribution, but also significantly associated with task characteristics. Military pilots demonstrated various visual scan patterns for searching and aiming at different types of targets based on the research settings of a flight simulator. The findings will facilitate system designers' understanding of military pilots' cognitive processes during tactical operations. They will assist human-centered interface design to improve pilots' situational awareness. The application of an eye-tracking device integrated with a flight simulator is a feasible and cost-effective intervention to improve the efficiency and safety of tactical training.Li W-C, Yu C-S, Braithwaite G, Greaves M. Pilots' attention distributions between chasing a moving target and a stationary target. Aerosp Med Hum Perform. 2016; 87(12):989-995.

Systemic administration of 8-OH-DPAT and eticlopride, but not SCH23390, alters loss-chasing behavior in the rat.

PubMed

Rogers, Robert D; Wong, Adeline; McKinnon, Chris; Winstanley, Catharine A

2013-05-01

Gambling to recover losses is a common gaming behavior. In a clinical context, however, this phenomenon mediates the relationship between diminished control over gambling and the adverse socioeconomic consequences of gambling problems. Modeling loss-chasing through analogous behaviors in rats could facilitate its pharmacological investigation as a potential therapeutic target. Here, rats were trained to make operant responses that produced both food rewards, and unpredictably, imminent time-out periods in which rewards would be unavailable. At these decision points, rats were offered choices between waiting for these time-out periods to elapse before resuming responding for rewards ('quit' responses), or selecting risky options with a 0.5 probability of avoiding the time-outs altogether and a 0.5 probability of time-out periods twice as long as signaled originally ('chase' responses). Chasing behavior, and the latencies to chase or quit, during sequences of unfavorable outcomes were tested following systemic administration of the 5-HT1A receptor agonist, 8-OH-DPAT, the D2 receptor antagonist, eticlopride, and the D1 receptor antagonist, SCH23390. 8-OH-DPAT and eticlopride significantly reduced the proportion of chase responses, and the mean number of consecutive chase responses, in a dose-dependent manner. 8-OH-DPAT also increased latencies to chase. Increasing doses of eticlopride first speeded, then slowed, latencies to quit while SCH23390 had no significant effects on any measure. Research is needed to identify the precise cognitive mechanisms mediating these kinds of risky choices in rats. However, our data provide the first experimental demonstration that 5-HT1A and D2, but not D1, receptor activity influence a behavioral analog of loss-chasing in rats.

Systemic Administration of 8-OH-DPAT and Eticlopride, but not SCH23390, Alters Loss-Chasing Behavior in the Rat

PubMed Central

Rogers, Robert D; Wong, Adeline; McKinnon, Chris; Winstanley, Catharine A

2013-01-01

Gambling to recover losses is a common gaming behavior. In a clinical context, however, this phenomenon mediates the relationship between diminished control over gambling and the adverse socioeconomic consequences of gambling problems. Modeling loss-chasing through analogous behaviors in rats could facilitate its pharmacological investigation as a potential therapeutic target. Here, rats were trained to make operant responses that produced both food rewards, and unpredictably, imminent time-out periods in which rewards would be unavailable. At these decision points, rats were offered choices between waiting for these time-out periods to elapse before resuming responding for rewards (‘quit' responses), or selecting risky options with a 0.5 probability of avoiding the time-outs altogether and a 0.5 probability of time-out periods twice as long as signaled originally (‘chase' responses). Chasing behavior, and the latencies to chase or quit, during sequences of unfavorable outcomes were tested following systemic administration of the 5-HT1A receptor agonist, 8-OH-DPAT, the D2 receptor antagonist, eticlopride, and the D1 receptor antagonist, SCH23390. 8-OH-DPAT and eticlopride significantly reduced the proportion of chase responses, and the mean number of consecutive chase responses, in a dose-dependent manner. 8-OH-DPAT also increased latencies to chase. Increasing doses of eticlopride first speeded, then slowed, latencies to quit while SCH23390 had no significant effects on any measure. Research is needed to identify the precise cognitive mechanisms mediating these kinds of risky choices in rats. However, our data provide the first experimental demonstration that 5-HT1A and D2, but not D1, receptor activity influence a behavioral analog of loss-chasing in rats. PMID:23303072

What are the underlying units of perceived animacy? Chasing detection is intrinsically object-based.

PubMed

van Buren, Benjamin; Gao, Tao; Scholl, Brian J

2017-10-01

One of the most foundational questions that can be asked about any visual process is the nature of the underlying 'units' over which it operates (e.g., features, objects, or spatial regions). Here we address this question-for the first time, to our knowledge-in the context of the perception of animacy. Even simple geometric shapes appear animate when they move in certain ways. Do such percepts arise whenever any visual feature moves appropriately, or do they require that the relevant features first be individuated as discrete objects? Observers viewed displays in which one disc (the "wolf") chased another (the "sheep") among several moving distractor discs. Critically, two pairs of discs were also connected by visible lines. In the Unconnected condition, both lines connected pairs of distractors; but in the Connected condition, one connected the wolf to a distractor, and the other connected the sheep to a different distractor. Observers in the Connected condition were much less likely to describe such displays using mental state terms. Furthermore, signal detection analyses were used to explore the objective ability to discriminate chasing displays from inanimate control displays in which the wolf moved toward the sheep's mirror-image. Chasing detection was severely impaired on Connected trials: observers could readily detect an object chasing another object, but not a line-end chasing another line-end, a line-end chasing an object, or an object chasing a line-end. We conclude that the underlying units of perceived animacy are discrete visual objects.

Paper Chase and the Socratic Method of Teaching Law.

ERIC Educational Resources Information Center

Dillon, J. T.

1980-01-01

It is argued that the Socratic method of teaching law as depicted in the book, movie, and TV series "Paper Chase" is not really the Socratic method at all. The genuine Socratic method and the questioning technique used in "Paper Chase" are examined and their appropriateness and effectiveness as methods for teaching contract law…

Social object play among young Japanese macaques (Macaca fuscata) in Arashiyama, Japan.

PubMed

Shimada, Masaki

2006-10-01

Social object play (SOP), i.e., social play using portable object(s), among young Japanese macaques (Macaca fuscata; 0-4 years old) in the Arashiyama E troop was studied using a modified sequence sampling method from July to October 2000. SOP was a relatively common activity for most of the young macaques and often continued for long periods. Participants used many kinds of object, including edible natural objects and artificial objects, such as plastic bottles, but they never used provisioned food or wild fruit in SOP bouts. An analysis of long bouts (>/=0.5 min) revealed the following interactive SOP features: (1) at any given time, participants used only one object, and only one participant held the object; (2) during SOP play-chasing, the object holder was likely to be chased by others; (3) during long bouts, the object changed hands frequently; and (4) agonistic competition for an object among young macaques was rare. Combinations of sexes, ages, relative ranks, or matrilines of the object holder and non-holder did not affect the tendency that the holder was chased by non-holder(s) during play-chasing. Even when there was a change in object holders, the repetitiveness of this interactive pattern, i.e., that the holder would be chased during SOP bouts, distinguished the SOP structure from that of other types of social play without object(s). General proximate social play mechanisms, such as self-handicapping or role taking, were associated with SOP. Other mechanisms that affected SOP included the following: (1) young macaques treated an object as a target in play competition, and (2) 'being the holder of a target object' was associated with the 'role of the chasee.'

78 FR 69663 - Jonathan and Jayne Chase Troy Mills Hydroelectric Inc.; Notice of Transfer of Exemption

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-20

... Jayne Chase Troy Mills Hydroelectric Inc.; Notice of Transfer of Exemption 1. By letter filed October 15, 2013, Jonathan Chase informed the Commission that the exemption from licensing for the Troy Hydroelectric Project, FERC No. 13381, originally issued December 2, 2011,\\1\\ has been transferred to Troy Mills...

The Effect of Laziness in Group Chase and Escape

NASA Astrophysics Data System (ADS)

Masuko, Makoto; Hiraoka, Takayuki; Ito, Nobuyasu; Shimada, Takashi

2017-08-01

The effect of laziness in the group chase and escape problem is studied using a simple model. Laziness is introduced as random walks in two ways: uniformly and in a "division of labor" way. It is shown that while the former is always ineffective, the latter can improve the efficiency of catching, through the formation of pincer attack configuration by diligent and lazy chasers.

Chameleon Chasing II: A Replication.

ERIC Educational Resources Information Center

Newsom, Doug A.; And Others

1993-01-01

Replicates a 1972 survey of students, educators, and Public Relations Society of America members regarding who the public relations counselor really serves. Finds that, in 1992, most respondents thought primary responsibility was to the client, then to the client's relevant publics, then to self, then to society, and finally to media. Compares…

Combat History Analysis Study Effort (CHASE) Data Enhancement Study (CDES). Volume 1. Introductory Materials and Bioliography.

DTIC Science & Technology

1986-01-31

Operations, France and Belgium, 1914: Mons, the Retreat to the Seine , the Marne , the Aisne, August-October 1914. London, 1922. Edmonds, Brig. Gen...7-175 712 COMBAT HISTORY ANAL YSIS STUDY EFFORT (CHASE) DATA l/f ENHANCEMENT STUDY CDES (U) DATA MEMORY SYSTEMS INC FAIRFAX VA HERO DIV B R BADER ET ...Fleville 350 Noyon-Montdidier 378 Hill 212 351 Champagne- Marne 379 Bois de Boyon- 352 Aisne- Marne I Montrefagne 353 Missy aux Bois Ravine 380 Hill 272 354

Following isotopes in pulse-chase enriched aspen seedlings

NASA Astrophysics Data System (ADS)

Norris, C. E.; Wasylishen, R. E.; Landhäusser, S.; Quideau, S. A.

2011-12-01

One method to quantitatively trace biogeochemical fluxes through ecosystems, such as organic matter decomposition, is to use plant material enriched with stable isotopes. However, as plant macromolecules are known to vary in their rate of formation and decomposition, both the enrichment levels and the location of enrichment within the plant material should be characterized prior to decomposition and tracing studies. Aspen (Populus tremuloides Michx.) is a common tree species with a diverse organic matter chemical structure found in the western Canadian boreal forest. This study used a multi pulse and multi chase enrichment of stable isotopes (15N and 13C) on aspen seedlings to determine the seedling enrichment, isotope movement among plant tissues and translocation of isotopes within plant macromolecules e.g., carbohydrates and lignin. As expected, all tissues experienced increased enrichment with multiple pulses. An initial enrichment with 13C was observed in the leaves followed by translocation to the stems and roots while the 15N moved upward from the roots to leaves. The macromolecular chemistry of the organic carbon was further characterized using 13C solid state nuclear magnetic resonance spectroscopy. After the initial two hour chase period enrichment of the O-alkyl type (carbohydrate) carbon within the leaves was identified, followed by redistribution to more complex carbon compounds after the one week chase period. Root and stem tissues did not show the same pattern. Rather, changes in 13C enrichment were observed in shifting ethyl and methyl alkyl (lipid) carbon peak intensities for the stem samples while roots did not preferentially allocate 13C to a specific macromolecule. These results confirm that stable isotope enrichment of plants was non-uniform across macromolecules and tissue types. Enrichment of aspen seedlings was therefore dependant on the pulse-chase sequence used.

Maternal programming of offspring hypothalamic-pituitary-interrenal axis in wild sockeye salmon (Oncorhynchus nerka).

PubMed

Sopinka, N M; Jeffrey, J D; Burnett, N J; Patterson, D A; Gilmour, K M; Hinch, S G

2017-02-01

In fishes, maternal exposure to a stressor can influence offspring size and behavior. However, less is known about how maternal stress influences physiological processes in offspring, such as function of the hypothalamic-pituitary-interrenal (HPI) axis. We examined the impact of chronic maternal exposure to an acute chase stressor on the stress response/HPI activity of progeny in wild sockeye salmon (Oncorhynchus nerka). Resting plasma cortisol and brain preoptic area (POA) corticotropin-releasing factor (CRF) mRNA levels did not vary between offspring reared from undisturbed, control females and offspring reared from females exposed to the stressor. However, resting levels of POA glucocorticoid receptors (GR1 and GR2), and head kidney melanocortin 2 receptor (MC2R), steroidogenic acute regulatory protein (StAR), and cytochrome P450 side chain cleavage enzyme (P450scc) were elevated in offspring reared from stressor-exposed females. Offspring reared from stressor-exposed females had lower plasma cortisol levels 1-h after an acute chase stressor compared to cortisol levels in offspring reared from control females. In offspring reared from chased females, mRNA levels of genes associated with cortisol biosynthesis were reduced in the head kidney post-chase. In offspring reared from control females, mRNA levels in the head kidney did not vary pre- to post-chase. Together, the results of the present study suggest maternal programming of progeny with respect to baseline and stressor-induced mediators of HPI axis activity. Copyright © 2015 Elsevier Inc. All rights reserved.

Attributing intentions to random motion engages the posterior superior temporal sulcus.

PubMed

Lee, Su Mei; Gao, Tao; McCarthy, Gregory

2014-01-01

The right posterior superior temporal sulcus (pSTS) is a neural region involved in assessing the goals and intentions underlying the motion of social agents. Recent research has identified visual cues, such as chasing, that trigger animacy detection and intention attribution. When readily available in a visual display, these cues reliably activate the pSTS. Here, using functional magnetic resonance imaging, we examined if attributing intentions to random motion would likewise engage the pSTS. Participants viewed displays of four moving circles and were instructed to search for chasing or mirror-correlated motion. On chasing trials, one circle chased another circle, invoking the percept of an intentional agent; while on correlated motion trials, one circle's motion was mirror reflected by another. On the remaining trials, all circles moved randomly. As expected, pSTS activation was greater when participants searched for chasing vs correlated motion when these cues were present in the displays. Of critical importance, pSTS activation was also greater when participants searched for chasing compared to mirror-correlated motion when the displays in both search conditions were statistically identical random motion. We conclude that pSTS activity associated with intention attribution can be invoked by top-down processes in the absence of reliable visual cues for intentionality.

Strategic Studies Quarterly. Volume 6, Number 2. Summer 2012

DTIC Science & Technology

2012-06-01

Jr . Forging an Indian Partnership Capt Craig H. Neuman II, USAF Chasing Its Tail: Nuclear Deterrence in the Information Age? Stephen J. Cimbala Commentary Our Brick Moon William H. Gerstenmaier ...Su m m er 2012 SUMMER 2012 Vol. 6, No. 2 Commentary Our Brick Moon William H. Gerstenmaier Chasing Its Tail: Nuclear Deterrence in...Extended Deterrence: How Much Strategic Force Is Too Little? David J. Trachtenberg The Common Sense of Small Nuclear Arsenals James Wood Forsyth

Building America Case Study: Duct in Conditioned Space in a Dropped Ceiling or Fur-down, Gainesville, Florida (Fact Sheet)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

2014-09-01

Forced air distribution systems (duct systems) typically are installed out of sight for aesthetic reasons, most often in unconditioned areas such as an attic or crawlspace. Any leakage of air to or from the duct system (duct leakage) in unconditioned space not only loses energy, but impacts home and equipment durability and indoor air quality. An obvious solution to this problem is to bring the duct system into the interior of the house, either by sealing the area where the ducts are installed (sealed attic or crawlspace) or by building an interior cavity or chase above the ceiling plane (raisedmore » ceiling or fur-up chase) or below the ceiling plane (dropped ceiling or fur-down) for the duct system. This case study examines one Building America builder partner's implementation of an inexpensive, quick and effective method of building a fur-down or dropped ceiling chase.« less

A Factor Increasing Venous Contamination on Bolus Chase Three-dimensional Magnetic Resonance Imaging: Charcot Neuroarthropathy.

PubMed

Çildağ, Mehmet B; Ertuğrul, Mustafa B; Köseoğlu, Ömer Fk; Armstrong, David G

2018-01-01

The study aimed to evaluate the ratio of venous contamination in diabetic cases without foot lesion, with foot lesion and with Charcot neuroarthropathy (CN). Bolus-chase three-dimensional magnetic resonance (MR) of 396 extremities of patients with diabetes mellitus was analyzed, retrospectively. Extremities were divided into three groups as follows: diabetic patients without foot ulcer or Charcot arthropathy (Group A), patients with diabetic foot ulcers (Group B) and patients with CN accompanying diabetic foot ulcers (Group C). Furthermore, amount of venous contamination classified as no venous contamination, mild venous contamination, and severe venous contamination. The relationship between venous contamination and extremity groups was investigated. Severe venous contamination was seen in Group A, Group B, and Group C, 5.6%, 15.2%, and 34.1%, respectively. Statistically significant difference was seen between groups with regard to venous contamination. Venous contamination following bolus chase MR was higher in patients with CN.

Technology Solutions Case Study: Duct in Conditioned Space in a Dropped Ceiling or Fur-down, Gainesville, Florida

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

2014-09-01

Forced-air distribution systems (duct systems) typically are installed out of sight for aesthetic reasons, most often in unconditioned areas such as attics or crawlspaces. Any leakage of air to or from the duct system in unconditioned space not only loses energy, but impacts home and equipment durability and indoor air quality. An obvious solution is to bring the duct system into the interior of the house, either by sealing the area where the ducts are installed (attic or crawlspace) or by building an interior cavity or chase above the ceiling plane (raised ceiling or fur-up chase) or below the ceilingmore » plane (dropped ceiling or fur-down) for the duct system. In this project, Building America Partnership for Improved Residential Construction team partnered with Tommy Williams Homes to implement an inexpensive, quick, and effective method of building a fur-down chase.« less

The influence of complex and threatening environments in early life on brain size and behaviour.

PubMed

DePasquale, C; Neuberger, T; Hirrlinger, A M; Braithwaite, V A

2016-01-27

The ways in which challenging environments during development shape the brain and behaviour are increasingly being addressed. To date, studies typically consider only single variables, but the real world is more complex. Many factors simultaneously affect the brain and behaviour, and whether these work independently or interact remains untested. To address this, zebrafish (Danio rerio) were reared in a two-by-two design in housing that varied in structural complexity and/or exposure to a stressor. Fish experiencing both complexity (enrichment objects changed over time) and mild stress (daily net chasing) exhibited enhanced learning and were less anxious when tested as juveniles (between 77 and 90 days). Adults tested (aged 1 year) were also less anxious even though fish were kept in standard housing after three months of age (i.e. no chasing or enrichment). Volumetric measures of the brain using magnetic resonance imaging (MRI) showed that complexity alone generated fish with a larger brain, but this increase in size was not seen in fish that experienced both complexity and chasing, or chasing alone. The results highlight the importance of looking at multiple variables simultaneously, and reveal differential effects of complexity and stressful experiences during development of the brain and behaviour. © 2016 The Authors.

The influence of complex and threatening environments in early life on brain size and behaviour

PubMed Central

Neuberger, T.; Hirrlinger, A. M.; Braithwaite, V. A.

2016-01-01

The ways in which challenging environments during development shape the brain and behaviour are increasingly being addressed. To date, studies typically consider only single variables, but the real world is more complex. Many factors simultaneously affect the brain and behaviour, and whether these work independently or interact remains untested. To address this, zebrafish (Danio rerio) were reared in a two-by-two design in housing that varied in structural complexity and/or exposure to a stressor. Fish experiencing both complexity (enrichment objects changed over time) and mild stress (daily net chasing) exhibited enhanced learning and were less anxious when tested as juveniles (between 77 and 90 days). Adults tested (aged 1 year) were also less anxious even though fish were kept in standard housing after three months of age (i.e. no chasing or enrichment). Volumetric measures of the brain using magnetic resonance imaging (MRI) showed that complexity alone generated fish with a larger brain, but this increase in size was not seen in fish that experienced both complexity and chasing, or chasing alone. The results highlight the importance of looking at multiple variables simultaneously, and reveal differential effects of complexity and stressful experiences during development of the brain and behaviour. PMID:26817780

Energy cost and return for hunting in African wild dogs and cheetahs.

PubMed

Hubel, Tatjana Y; Myatt, Julia P; Jordan, Neil R; Dewhirst, Oliver P; McNutt, J Weldon; Wilson, Alan M

2016-03-29

African wild dogs (Lycaon pictus) are reported to hunt with energetically costly long chase distances. We used high-resolution GPS and inertial technology to record 1,119 high-speed chases of all members of a pack of six adult African wild dogs in northern Botswana. Dogs performed multiple short, high-speed, mostly unsuccessful chases to capture prey, while cheetahs (Acinonyx jubatus) undertook even shorter, higher-speed hunts. We used an energy balance model to show that the energy return from group hunting and feeding substantially outweighs the cost of multiple short chases, which indicates that African wild dogs are more energetically robust than previously believed. Comparison with cheetah illustrates the trade-off between sheer athleticism and high individual kill rate characteristic of cheetahs, and the energetic robustness of frequent opportunistic group hunting and feeding by African wild dogs.

The CHASE laboratory search for chameleon dark energy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Steffen, Jason H.; /Fermilab

2010-11-01

A scalar field is a favorite candidate for the particle responsible for dark energy. However, few theoretical means exist that can simultaneously explain the observed acceleration of the Universe and evade tests of gravity. The chameleon mechanism, whereby the properties of a particle depend upon the local environment, is one possible avenue. We present the results of the Chameleon Afterglow Search (CHASE) experiment, a laboratory probe for chameleon dark energy. CHASE marks a significant improvement other searches for chameleons both in terms of its sensitivity to the photon/chameleon coupling as well as its sensitivity to the classes of chameleon darkmore » energy models and standard power-law models. Since chameleon dark energy is virtually indistinguishable from a cosmological constant, CHASE tests dark energy models in a manner not accessible to astronomical surveys.« less

Bobcat attack on a cottontail rabbit

USGS Publications Warehouse

Biggins, D.E.; Biggins, D.M.

2006-01-01

We observed an attack by a bobcat (Lynx rufus) on a cottontail rabbit (Sylvilagus) that involved stealthy approach by the cat for >1 h, followed by a 12.3-s chase covering 116.0 m for the cat and 128.4 m for the rabbit. During the chase, the route of the cat from starting point to kill site was more direct than the semi-circular route of the rabbit. Stride lengths for the cat and total distance covered by the chase were longer than those previously reported for bobcats.

78 FR 42777 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-17

... President) 100 North 6th Street, Philadelphia, Pennsylvania 19105-1521: 1. Fox Chase Bancorp Inc., Hatboro, Pennsylvania; to become a bank holding company upon the conversion of Fox Chase Bank, Hatboro, Pennsylvania...

Energy cost and return for hunting in African wild dogs and cheetahs

PubMed Central

Hubel, Tatjana Y.; Myatt, Julia P.; Jordan, Neil R.; Dewhirst, Oliver P.; McNutt, J. Weldon; Wilson, Alan M.

2016-01-01

African wild dogs (Lycaon pictus) are reported to hunt with energetically costly long chase distances. We used high-resolution GPS and inertial technology to record 1,119 high-speed chases of all members of a pack of six adult African wild dogs in northern Botswana. Dogs performed multiple short, high-speed, mostly unsuccessful chases to capture prey, while cheetahs (Acinonyx jubatus) undertook even shorter, higher-speed hunts. We used an energy balance model to show that the energy return from group hunting and feeding substantially outweighs the cost of multiple short chases, which indicates that African wild dogs are more energetically robust than previously believed. Comparison with cheetah illustrates the trade-off between sheer athleticism and high individual kill rate characteristic of cheetahs, and the energetic robustness of frequent opportunistic group hunting and feeding by African wild dogs. PMID:27023457

T-34C back seat instrument panel

NASA Image and Video Library

1997-05-15

The back seat instrument panel on the NASA T-34C chase plane. In its role as a military trainer, the instructor pilot would ride in the back seat, while the student would be in the front seat. As a chase plane, the back seat would be occupied by a photographer. The aircraft was previously used at the Lewis Research Center in propulsion experiments involving turboprop engines, and was used as a chase aircraft at Dryden for smaller and slower research projects. Chase aircraft accompany research flights for photography and video purposes, and also as support for safety and research. At Dryden, the T-34 is used mainly for smaller remotely piloted vehicles which fly slower than NASA's F-18's, used for larger scale projects. This aircraft was returned to the U.S. Navy in May of 2002. The T-34C, built by Beech, carries a crew of 2 and is nicknamed the Mentor.

Tornado Chasing.

ERIC Educational Resources Information Center

Faidley, Warren

1991-01-01

Presents the rationale and purposes behind the phenomenon known as storm chasing, as well as the contributions that tornado chasers have made to both scientific knowledge and public safety. Provides statistical information on tornado frequencies and locations and contact addresses for storm chasers. (JJK)

Initial Results of Interdisciplinary Science Enabled by Eclipse 2017: NASA Perspective

NASA Astrophysics Data System (ADS)

Guhathakurta, M.

2017-12-01

The exceptionally long path over land of the August 21st total and partial solar eclipse provided an unprecedented opportunity for cross disciplinary studies of the sun, moon, Earth, and their interactions. NASA supported research using ground-based measurements, balloons and planes that "chased" the eclipse as well as data taken from a vast array of orbiting spacecraft, all of which helped scientists take continuous measurements of the sun and the effects of the eclipse on the ionosphere and Earth for relatively long periods of time. This talk will summarize some of the initial findings from these research.

Neural correlates of effective learning in experienced medical decision-makers.

PubMed

Downar, Jonathan; Bhatt, Meghana; Montague, P Read

2011-01-01

Accurate associative learning is often hindered by confirmation bias and success-chasing, which together can conspire to produce or solidify false beliefs in the decision-maker. We performed functional magnetic resonance imaging in 35 experienced physicians, while they learned to choose between two treatments in a series of virtual patient encounters. We estimated a learning model for each subject based on their observed behavior and this model divided clearly into high performers and low performers. The high performers showed small, but equal learning rates for both successes (positive outcomes) and failures (no response to the drug). In contrast, low performers showed very large and asymmetric learning rates, learning significantly more from successes than failures; a tendency that led to sub-optimal treatment choices. Consistently with these behavioral findings, high performers showed larger, more sustained BOLD responses to failed vs. successful outcomes in the dorsolateral prefrontal cortex and inferior parietal lobule while low performers displayed the opposite response profile. Furthermore, participants' learning asymmetry correlated with anticipatory activation in the nucleus accumbens at trial onset, well before outcome presentation. Subjects with anticipatory activation in the nucleus accumbens showed more success-chasing during learning. These results suggest that high performers' brains achieve better outcomes by attending to informative failures during training, rather than chasing the reward value of successes. The differential brain activations between high and low performers could potentially be developed into biomarkers to identify efficient learners on novel decision tasks, in medical or other contexts.

Goal attribution to inanimate moving objects by Japanese macaques (Macaca fuscata)

PubMed Central

Atsumi, Takeshi; Koda, Hiroki; Masataka, Nobuo

2017-01-01

Humans interpret others’ goals based on motion information, and this capacity contributes to our mental reasoning. The present study sought to determine whether Japanese macaques (Macaca fuscata) perceive goal-directedness in chasing events depicted by two geometric particles. In Experiment 1, two monkeys and adult humans were trained to discriminate between Chasing and Random sequences. We then introduced probe stimuli with various levels of correlation between the particle trajectories to examine whether participants performed the task using higher correlation. Participants chose stimuli with the highest correlations by chance, suggesting that correlations were not the discriminative cue. Experiment 2 examined whether participants focused on particle proximity. Participants differentiated between Chasing and Control sequences; the distance between two particles was identical in both. Results indicated that, like humans, the Japanese macaques did not use physical cues alone to perform the discrimination task and integrated the cues spontaneously. This suggests that goal attribution resulting from motion information is a widespread cognitive phenotype in primate species. PMID:28053305

Physical Activity Play and Preschool Children's Peer Acceptance: Distinctions between Rough-and-Tumble and Exercise Play

ERIC Educational Resources Information Center

Lindsey, Eric W.

2014-01-01

Research Findings: Two forms of exercise play (toy mediated and non-mediated) and 2 forms of rough-and-tumble (R&T) play (chase and fighting) were examined in relation to preschoolers' peer competence. A total of 148 preschoolers (78 boys, 89 Euro-Americans) were observed during free play at their university-sponsored child care center. The…

White Hats Chasing Black Hats: Careers in IT and the Skills Required to Get There. Advisory from Professionals

ERIC Educational Resources Information Center

Fulton, Eric; Lawrence, Cameron; Clouse, Shawn

2013-01-01

The aim of this paper is to illuminate the exciting world in which "white hat crackers" operate and to suggest topics that can help prepare students to enter this high-demand field. While currently there is extraordinary demand for graduates to fill these positions that have relatively high starting salaries, employers find it difficult…

NASA's Global Hawk

NASA Image and Video Library

2014-09-23

View from a Chase Plane; HS3 Science Flight 8 Wraps Up The chase plane accompanying NASA's Global Hawk No. 872 captured this picture on Sept. 19 after the Global Hawk completed science flight #8 where it gathered data from a weakening Tropical Storm Edouard over the North Atlantic Ocean. Credit: NASA -- The Hurricane and Severe Storm Sentinel (HS3) is a five-year mission specifically targeted to investigate the processes that underlie hurricane formation and intensity change in the Atlantic Ocean basin. HS3 is motivated by hypotheses related to the relative roles of the large-scale environment and storm-scale internal processes. Read more: espo.nasa.gov/missions/hs3/mission-gallery NASA image use policy. NASA Goddard Space Flight Center enables NASA’s mission through four scientific endeavors: Earth Science, Heliophysics, Solar System Exploration, and Astrophysics. Goddard plays a leading role in NASA’s accomplishments by contributing compelling scientific knowledge to advance the Agency’s mission. Follow us on Twitter Like us on Facebook Find us on Instagram

76 FR 24912 - Sunshine Act Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-03

... DEPARTMENT OF JUSTICE Parole Commission Sunshine Act Meeting TIME AND DATE: 11 a.m., Tuesday, May 10, 2011. PLACE: U.S. Parole Commission, 5550 Friendship Boulevard, Chevy Chase, Maryland. STATUS... the Chairman, U.S. Parole Commission, 5550 Friendship Boulevard, Chevy Chase, Maryland 20815, (301...

Validity of chase car data used in developing emissions cycles

DOT National Transportation Integrated Search

2000-09-01

Air quality policies, driving cycles and profiles of average driving behavior have been constructed to characterize the driving behavior of the overall fleet in an effort to ensure vehicle compliance. Chase car data and speed-time profiles of in-use ...

Pro-inflammatory adjuvant properties of pigment-grade titanium dioxide particles are augmented by a genotype that potentiates interleukin 1β processing.

PubMed

Riedle, Sebastian; Pele, Laetitia C; Otter, Don E; Hewitt, Rachel E; Singh, Harjinder; Roy, Nicole C; Powell, Jonathan J

2017-12-08

Pigment-grade titanium dioxide (TiO 2 ) particles are an additive to some foods (E171 on ingredients lists), toothpastes, and pharma-/nutraceuticals and are absorbed, to some extent, in the human intestinal tract. TiO 2 can act as a modest adjuvant in the secretion of the pro-inflammatory cytokine interleukin 1β (IL-1β) when triggered by common intestinal bacterial fragments, such as lipopolysaccharide (LPS) and/or peptidoglycan. Given the variance in human genotypes, which includes variance in genes related to IL-1β secretion, we investigated whether TiO 2 particles might, in fact, be more potent pro-inflammatory adjuvants in cells that are genetically susceptible to IL-1β-related inflammation. We studied bone marrow-derived macrophages from mice with a mutation in the nucleotide-binding oligomerisation domain-containing 2 gene (Nod2 m/m ), which exhibit heightened secretion of IL-1β in response to the peptidoglycan fragment muramyl dipeptide (MDP). To ensure relevance to human exposure, TiO 2 was food-grade anatase (119 ± 45 nm mean diameter ± standard deviation). We used a short 'pulse and chase' format: pulsing with LPS and chasing with TiO 2 +/- MDP or peptidoglycan. IL-1β secretion was not stimulated in LPS-pulsed bone marrow-derived macrophages, or by chasing with MDP, and only very modestly so by chasing with peptidoglycan. In all cases, however, IL-1β secretion was augmented by chasing with TiO 2 in a dose-dependent fashion (5-100 μg/mL). When co-administered with MDP or peptidoglycan, IL-1β secretion was further enhanced for the Nod2 m/m genotype. Tumour necrosis factor α was triggered by LPS priming, and more so for the Nod2 m/m genotype. This was enhanced by chasing with TiO 2 , MDP, or peptidoglycan, but there was no additive effect between the bacterial fragments and TiO 2 . Here, the doses of TiO 2 that augmented bacterial fragment-induced IL-1β secretion were relatively high. In vivo, however, selected intestinal cells appear to be loaded with TiO 2 , so such high concentrations may be 'exposure-relevant' for localised regions of the intestine where both TiO 2 and bacterial fragment uptake occurs. Moreover, this effect is enhanced in cells from Nod2 m/m mice indicating that genotype can dictate inflammatory signalling in response to (nano)particle exposure. In vivo studies are now merited.

Why Most Published Research Findings Are False

PubMed Central

Ioannidis, John P. A.

2005-01-01

Summary There is increasing concern that most current published research findings are false. The probability that a research claim is true may depend on study power and bias, the number of other studies on the same question, and, importantly, the ratio of true to no relationships among the relationships probed in each scientific field. In this framework, a research finding is less likely to be true when the studies conducted in a field are smaller; when effect sizes are smaller; when there is a greater number and lesser preselection of tested relationships; where there is greater flexibility in designs, definitions, outcomes, and analytical modes; when there is greater financial and other interest and prejudice; and when more teams are involved in a scientific field in chase of statistical significance. Simulations show that for most study designs and settings, it is more likely for a research claim to be false than true. Moreover, for many current scientific fields, claimed research findings may often be simply accurate measures of the prevailing bias. In this essay, I discuss the implications of these problems for the conduct and interpretation of research. PMID:16060722

6. CONSTRUCTION PROGRESS VIEW (EXTERIOR) OF TANK, CABLE CHASE, AND ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

6. CONSTRUCTION PROGRESS VIEW (EXTERIOR) OF TANK, CABLE CHASE, AND MOUNDED BUNKER. CONSTRUCTION WAS 99 PERCENT COMPLETE. CAMERA IS FACING WEST. INEL PHOTO NUMBER 65-5435, TAKEN OCTOBER 20, 1965. - Idaho National Engineering Laboratory, Advanced Reentry Vehicle Fusing System, Scoville, Butte County, ID

A compilation of chase work characterizes this image, looking south, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

A compilation of chase work characterizes this image, looking south, in the niche which slightly separates E Building form R Building, on the north side - Department of Energy, Mound Facility, Electronics Laboratory Building (E Building), One Mound Road, Miamisburg, Montgomery County, OH

Stare and chase of space debris targets using real-time derived pointing data

NASA Astrophysics Data System (ADS)

Steindorfer, Michael A.; Kirchner, Georg; Koidl, Franz; Wang, Peiyuan; Antón, Alfredo; Fernández Sánchez, Jaime; Merz, Klaus

2017-09-01

We successfully demonstrate Stare & Chase: Space debris laser ranging to uncooperative targets has been achieved without a priori knowledge of any orbital information. An analog astronomy CCD with a standard objective, piggyback mounted on our 50 cm Graz SLR receive telescope, 'stares' into the sky in a fixed direction. The CCD records the stellar background within a field of view of approx. 7°. From the stellar X/Y positions on the sensor a plate solving algorithm determines the pointing data of the image center with an accuracy of approx. 15 arc seconds. If a sunlit target passes through this field of view, its equatorial coordinates are calculated, stored and a Consolidated Prediction Format (CPF) file is created in near real time. The derived CPF data is used to start laser ranging ('chase' the object) within the same pass to retrieve highly accurate distance information. A comparison of Stare & Chase CPFs with standard TLE predictions shows the possibilities and limits of this method.

Retention Kinetics of the 18F-Labeled Sympathetic Nerve PET Tracer LMI1195: Comparison with 11C-Hydroxyephedrine and 123I-MIBG.

PubMed

Werner, Rudolf A; Rischpler, Christoph; Onthank, David; Lapa, Constantin; Robinson, Simon; Samnick, Samuel; Javadi, Mehrbod; Schwaiger, Markus; Nekolla, Stephan G; Higuchi, Takahiro

2015-09-01

(18)F-N-[3-bromo-4-(3-fluoro-propoxy)-benzyl]-guanidine ((18)F-LMI1195) is a new PET tracer designed for noninvasive assessment of sympathetic innervation of the heart. The (18)F label facilitates the imaging advantages of PET over SPECT technology while allowing centralized manufacturing. Highly specific neural uptake of (18)F-LMI1195 has previously been established, but the retention kinetics are not yet fully understood. Healthy New Zealand White rabbits were studied with (18)F-LMI1195 using a small-animal PET system. Dynamic 40-min chest scans were started just before intravenous bolus injection of (18)F-LMI1195. Imaging was performed under norepinephrine transport inhibition with desipramine pretreatment, a 1.5 mg/kg desipramine chase administered 10 min after tracer injection, and saline treatment of controls. As a reference, cardiac uptake of (11)C-hydroxyephedrine and (123)I-metaiodobenzylguanidine ((123)I-MIBG) was examined by PET and planar scintigraphy, respectively. Cardiac uptake of all 3 tracers was inhibited by pretreatment with desipramine. Stable cardiac tracer retention was delineated by dynamic PET in control rabbits for (11)C-hydroxyephedrine (washout rate, 0.42% ± 0.57%/min) and (18)F-LMI1195 (washout rate, 0.058% ± 0.28%/min). A desipramine chase increased (11)C-hydroxyephedrine washout from the heart (2.43% ± 0.15%/min, P < 0.001), whereas (18)F-LMI1195 washout was not influenced (0.059% ± 0.11%/min, not statistically significant). Additionally, a desipramine chase did not change the cardiac (123)I-MIBG uptake (delayed heart-to-mediastinum ratio, 1.99 ± 0.12 (desipramine chase) vs. 2.05 ± 0.16 (controls), not statistically significant). In vivo norepinephrine transporter (NET) blockade with desipramine confirmed specific neural uptake of (18)F-LMI1195, (11)C-hydroxyephedrine, and (123)I-MIBG in rabbit hearts. (11)C-hydroxyephedrine cardiac retention was sensitive to a NET inhibitor chase, indicating a cycle of continuous NET uptake and release at the nerve terminals. In contrast, (18)F-LMI1195 and (123)I-MIBG demonstrated stable storage at the nerve terminal with resistance to a NET inhibitor chase, mimicking physiologic norepinephrine turnover. © 2015 by the Society of Nuclear Medicine and Molecular Imaging, Inc.

Stepped leaders observed in ground operations of ADELE

NASA Astrophysics Data System (ADS)

Smith, D. M.; Kelley, N.; Lowell, A.; Martinez-McKinney, F.; Dwyer, J. R.; Splitt, M. E.; Lazarus, S. M.; Cramer, E. S.; Levine, S.; Cummer, S. A.; Lu, G.; Shao, X.; Ho, C.; Eastvedt, E. M.; Trueblood, J.; Edens, H. E.; Hunyady, S. J.; Winn, W. P.; Rassoul, H. K.

2010-12-01

While the Airborne Detector for Energetic Lightning Emissions (ADELE) was designed primarily to study high-energy radiation associated with thunderstorms at aircraft altitude, it can also be used as a mobile ground-based instrument when mounted in a van. ADELE contains scintillation detectors optimized for faint and bright events and a flat-plate antenna measuring dE/dt. In July and August 2010, ADELE was brought to Langmuir Laboratory in New Mexico as a stationary detector and to the Florida peninsula (based at the Florida Institute of Technology in Melbourne) for rapid-response (storm-chasing) operations. In ten days of chasing, stepped-leader x-ray emission was observed from at least four close CG flashes, a much higher rate of success than can be achieved from a stationary detector or array. We will present these four events as well as the results of a study of candidate events of lesser statistical significance. We will also discuss the optimization of lightning-chasing strategies, science goals for future ground campaigns, and what additional instrumentation would be most scientifically beneficial. In the latter category, a proximity sensor (comparing flash and thunder arrival times) and a field mill are particularly important.

Assessing Threat Detection Scenarios through Hypothesis Generation and Testing

DTIC Science & Technology

2015-12-01

task of playing chess with that of diagnosing medical conditions. Whereas both chess players and physicians must recognize patterns among a fixed...additional cues, all while maintaining these details in memory. Thus, the common research finding that chess experts can hold and process more information...of General Psychology, 124, 19-34. Chase, W. G., & Simon, H. A. (1973). Perception in chess . Cognitive Psychology, 4, 55-81. Choi, E., & Lee

What Do Tag Games Teach?

ERIC Educational Resources Information Center

Belka, David

2006-01-01

Tag games have been described as "Chasing, fleeing, and dodging" type activities. Most "fleeing" activities involve dramatic play, use of movement concepts (such as quick and light), or movement changes without a partner, while many of the chasing and dodging activities utilize dodging concepts between partners or within small groups and are…

78 FR 18801 - Establishment of Class E Airspace; Beeville, TX

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-28

... Instrument Approach Procedures at Chase Field Industrial Airport. The FAA is taking this action to enhance the safety and management of Instrument Flight Rule (IFR) operations at the airport. DATES: Effective... Federal Register a notice of proposed rulemaking (NPRM) to establish Class E airspace at Chase Industrial...

Smoking tobacco along with marijuana increases symptoms of cannabis dependence

PubMed Central

Ream, Geoffrey L.; Benoit, Ellen; Johnson, Bruce D.; Dunlap, Eloise

2008-01-01

Aim User practices/rituals that involve concurrent use of tobacco and marijuana – smoking blunts and “chasing” marijuana with tobacco – are hypothesized to increase cannabis dependence symptoms. Design Ethnographers administered group surveys to a diverse, purposive sample of marijuana users who appeared to be 17–35 years old. Setting New York City, including non-impoverished areas of Manhattan, the transitional area of East Village/Lower East Side, low-income areas of northern Manhattan and South Bronx, and diverse areas of Brooklyn and Queens. Participants 481 marijuana users ages 14–35, 57% male, 43% female; 27% White, 30% Black, 19% Latino, 5% Asian, 20% of other/multiple race. Measurements Among many other topics, group surveys measured cannabis dependence symptoms; frequencies of chasing, blunt smoking, joint/pipe smoking, using marijuana while alone, and general tobacco use; and demographic factors. Findings Blunt smoking and chasing marijuana with tobacco were each uniquely associated with five of the seven cannabis dependence symptoms. Across symptoms, predicted odds were 2.4–4.1 times greater for participants who smoked blunts on all 30 of the past 30 days than for participants who did not smoke blunts in the past 30 days. Significant increases in odds over the whole range of the five-point chasing frequency measure (from never to always) ranged from 3.4 times to 5.1 times. Conclusions Using tobacco with marijuana – smoking blunts and “chasing” marijuana with tobacco – contributes to cannabis dependence symptoms. Treatment for cannabis dependence may be more effective it addresses the issue of concurrent tobacco use. PMID:18339491

Geology and hydrogeology of Naval Air Station Chase Field and Naval Auxiliary Landing Field Goliad, Bee and Goliad counties, Texas

USGS Publications Warehouse

Snyder, G.L.

1995-01-01

Large vertical hydraulic-head gradients are present between the unconfined Evangeline aquifer and confined Fleming aquifers at Naval Air Station Chase Field and Naval Auxiliary Landing Field Goliad. These gradients, together with the results of the aquifer test at Naval Air Station Chase Field and assumed characteristics of the confining units, indicate that downward flow of ground water probably occurs from the water-table aquifer to the underlying aquifers. The rate of downward flow between the two confined Fleming aquifers (from A-sand to B-sand) can be approximated using an estimate of vertical hydraulic conductivity of the intervening confining unit obtained from assumed storage characteristics and data from the aquifer test. Under the relatively high vertical hydraulic-head gradient induced by the aquifer test, ground-water movement from the A-sand aquifer to the B-sand aquifer could require about 490 years; and about 730 years under the natural gradient. Future increases in ground-water withdrawals from the B-sand aquifer might increase downward flow in the aquifer system of the study area.

Magnetic state selected by magnetic dipole interaction in the kagome antiferromagnet NaBa2Mn3F11

NASA Astrophysics Data System (ADS)

Hayashida, Shohei; Ishikawa, Hajime; Okamoto, Yoshihiko; Okubo, Tsuyoshi; Hiroi, Zenji; Avdeev, Maxim; Manuel, Pascal; Hagihala, Masato; Soda, Minoru; Masuda, Takatsugu

2018-02-01

We haved studied the ground state of the classical kagome antiferromagnet NaBa2Mn3F11 . Strong magnetic Bragg peaks observed for d spacings shorter than 6.0 Å were indexed by the propagation vector of k0=(0 ,0 ,0 ) . Additional peaks with weak intensities in the d -spacing range above 8.0 Å were indexed by the incommensurate vector of k1=[0.3209 (2 ) ,0.3209 (2 ) ,0 ] and k2=[0.3338 (4 ) ,0.3338 (4 ) ,0 ] . Magnetic structure analysis unveils a 120∘ structure with the tail-chase geometry having k0 modulated by the incommensurate vector. A classical calculation of the Heisenberg kagome antiferromagnet with antiferromagnetic second-neighbor interaction, for which the ground state a k0120∘ degenerated structure, reveals that the magnetic dipole-dipole (MDD) interaction including up to the fourth neighbor terms selects the tail-chase structure. The observed modulation of the tail-chase structure is attributed to a small perturbation such as the long-range MDD interaction or the interlayer interaction.

On the anomalous afterglow seen in a chameleon afterglow search

DOE Office of Scientific and Technical Information (OSTI.GOV)

Steffen, Jason H.; Baumbaugh, Alan; Chou, Aaron S.

2012-05-01

We present data from our investigation of the anomalous orange-colored afterglow that was seen in the GammeV Chameleon Afterglow Search (CHASE). These data include information about the broadband color of the observed glow, the relationship between the glow and the temperature of the apparatus, and other data taken prior to, and during the science operations of CHASE. While differing in several details, the generic properties of the afterglow from CHASE are similar to luminescence seen in some vacuum compounds. Contamination from this, or similar, luminescent signatures will likely impact the design of implementation of future experiments involving single photon detectorsmore » and high intensity light sources in a cryogenic environment.« less

Aggregation increases prey survival time in group chase and escape

NASA Astrophysics Data System (ADS)

Yang, Sicong; Jiang, Shijie; Jiang, Li; Li, Geng; Han, Zhangang

2014-08-01

Recently developed chase-and-escape models have addressed a fascinating pursuit-and-evasion problem that may have both theoretical significance and potential applications. We introduce three aggregation strategies for the prey in a group chase model on a lattice. Simulation results show that aggregation dramatically increases the group survival time, even allowing immortal prey. The average survival time τ and the aggregation probability P have a power-law dependence of \\tau \\sim {{(1-P)}^{-1}} for P\\in [0.9,0.997]. With increasing numbers of predators, there is still a phase transition. When the number of predators is less than the critical point value, the prey group survival time increases significantly.

Chase and NYANA: A Partnership To Remove Barriers to Job Performance 1993-94. Final Report.

ERIC Educational Resources Information Center

Auerbach, Charles

A workplace literacy program implemented cooperatively by the New York Association for New Americans, Inc. (NYANA) and Chase Manhattan Bank is reported. The federally-funded project provided individualized communication workplace behavior and skills training in English as a Second Language for 30 limited-English-proficient bank employees working…

Identifying Determinants of PARP Inhibitor Sensitivity in Ovarian Cancer

DTIC Science & Technology

2017-10-01

Cancer Center Philadelphia, PA 19111 REPORT DATE: TYPE OF REPORT: Annual PREPARED FOR: U.S. Army Medical Research and Materiel Command Fort Detrick...in Ovarian Cancer October 2017 The views, opinions and/or findings contained in this report are those of the author(s) and should not be construed...ORGANIZATION NAME(S) AND ADDRESS(ES) 8. PERFORMING ORGANIZATION REPORT NUMBER The Research Institute of Fox Chase Cancer Center 333 Cottman Avenue Philadelphia

High-resolution gadolinium-enhanced 3D MRA of the infrapopliteal arteries. Lessons for improving bolus-chase peripheral MRA.

PubMed

Hood, Maureen N; Ho, Vincent B; Foo, Thomas K F; Marcos, Hani B; Hess, Sandra L; Choyke, Peter L

2002-09-01

Peripheral magnetic resonance angiography (MRA) is growing in use. However, methods of performing peripheral MRA vary widely and continue to be optimized, especially for improvement in illustration of infrapopliteal arteries. The main purpose of this project was to identify imaging factors that can improve arterial visualization in the lower leg using bolus chase peripheral MRA. Eighteen healthy adults were imaged on a 1.5T MR scanner. The calf was imaged using conventional three-station bolus chase three-dimensional (3D) MRA, two dimensional (2D) time-of-flight (TOF) MRA and single-station Gadolinium (Gd)-enhanced 3D MRA. Observer comparisons of vessel visualization, signal to noise ratios (SNR), contrast to noise ratios (CNR) and spatial resolution comparisons were performed. Arterial SNR and CNR were similar for all three techniques. However, arterial visualization was dramatically improved on dedicated, arterial-phase Gd-enhanced 3D MRA compared with the multi-station bolus chase MRA and 2D TOF MRA. This improvement was related to optimization of Gd-enhanced 3D MRA parameters (fast injection rate of 2 mL/sec, high spatial resolution imaging, the use of dedicated phased array coils, elliptical centric k-space sampling and accurate arterial phase timing for image acquisition). The visualization of the infrapopliteal arteries can be substantially improved in bolus chase peripheral MRA if voxel size, contrast delivery, and central k-space data acquisition for arterial enhancement are optimized. Improvements in peripheral MRA should be directed at these parameters.

Predator evasion by white-tailed deer fawns

USGS Publications Warehouse

Grovenburg, Troy W.; Monteith, Kevin L.; Klaver, Robert W.; Jenks, Jonathan A.

2012-01-01

Despite their importance for understanding predator–prey interactions, factors that affect predator evasion behaviours of offspring of large ungulates are poorly understood. Our objective was to characterize the influence of selection and availability of escape cover and maternal presence on predator evasion by white-tailed deer, Odocoileus virginianus, fawns in the northern Great Plains, U.S.A. We observed 45 coyote, Canis latrans, chases of fawns, and we participated in 83 human chases of fawns during 2007–2009, of which, 19 and 42 chases, respectively, ended with capture of the fawn. Evasive techniques used by fawns were similar for human and coyote chases. Likelihood of a white-tailed deer fawn escaping capture, however, was influenced by deer group size and a number of antipredator behaviours, including aggressive defence by females, initial habitat and selection of escape cover, all of which were modified by the presence of parturient females. At the initiation of a chase, fawns in grasslands were more likely to escape, whereas fawns in forested cover, cultivated land or wheat were more likely to be captured by a coyote or human. Fawns fleeing to wetlands and grasslands also were less likely to be captured compared with those choosing forested cover, wheat and cultivated land. Increased probability of capture was associated with greater distance to wetland and grassland habitats and decreased distance to wheat. Use of wetland habitat as a successful antipredator strategy highlights the need for a greater understanding of the importance of habitat complexity in predator avoidance.

Sexually dimorphic aggression indicates male gray wolves specialize in pack defense against conspecific groups

USGS Publications Warehouse

Cassidy, Kira A.; Mech, L. David; MacNulty, Daniel R; Stahler, Daniel R.; Smith, Douglas W.

2017-01-01

Aggression directed at conspecific groups is common among gregarious, territorial species, and for some species such as gray wolves (Canis lupus) intraspecific strife is the leading cause of natural mortality. Each individual in a group likely has different measures of the costs and benefits associated with a group task, such as an aggressive attack on another group, which can alter motivation and behavior. We observed 292 inter-pack aggressive interactions in Yellowstone National Park between 1 April 1995 and 1 April 2011 (>5300 days of observation) in order to determine the role of both sexes, and the influence of pack, age, and other traits on aggression. We recorded the behaviors and characteristics of all individuals present during the interactions (n = 534 individuals) and which individuals participated in each step (i.e. chase, attack, kill, flight) of the interaction. Overall, all wolves were more likely to chase rivals if they outnumbered their opponent, suggesting packs accurately assess their opponent’s size during encounters and individuals adjust their behavior based on relative pack size. Males were more likely than females to chase rival packs and gray-colored wolves were more aggressive than black-colored wolves. Male wolves and gray-colored wolves also recorded higher cortisol levels than females and black-colored wolves, indicating hormonal support for more intense aggressive behavior. Further, we found a positive correlation between male age and probability of chasing, while age-specific participation for females remained constant. Chasing behavior was influenced by the sex of lone intruders, with males more likely to chase male intruders. This difference in behavior suggests male and female wolves may have different strategies and motivations during inter-pack aggressive interactions related to gray wolf mating systems. A division of labor between pack members concerning resource and territory defense suggests selection for specific traits related to aggression is an adaptive response to intense competition between groups of conspecifics.

Sexually dimorphic aggression indicates male gray wolves specialize in pack defense against conspecific groups.

PubMed

Cassidy, Kira A; Mech, L David; MacNulty, Daniel R; Stahler, Daniel R; Smith, Douglas W

2017-03-01

Aggression directed at conspecific groups is common among gregarious, territorial species, and for some species such as gray wolves (Canis lupus) intraspecific strife is the leading cause of natural mortality. Each individual in a group likely has different measures of the costs and benefits associated with a group task, such as an aggressive attack on another group, which can alter motivation and behavior. We observed 292 inter-pack aggressive interactions in Yellowstone National Park between 1 April 1995 and 1 April 2011 (>5300days of observation) in order to determine the role of both sexes, and the influence of pack, age, and other traits on aggression. We recorded the behaviors and characteristics of all individuals present during the interactions (n=534 individuals) and which individuals participated in each step (i.e. chase, attack, kill, flight) of the interaction. Overall, all wolves were more likely to chase rivals if they outnumbered their opponent, suggesting packs accurately assess their opponent's size during encounters and individuals adjust their behavior based on relative pack size. Males were more likely than females to chase rival packs and gray-colored wolves were more aggressive than black-colored wolves. Male wolves and gray-colored wolves also recorded higher cortisol levels than females and black-colored wolves, indicating hormonal support for more intense aggressive behavior. Further, we found a positive correlation between male age and probability of chasing, while age-specific participation for females remained constant. Chasing behavior was influenced by the sex of lone intruders, with males more likely to chase male intruders. This difference in behavior suggests male and female wolves may have different strategies and motivations during inter-pack aggressive interactions related to gray wolf mating systems. A division of labor between pack members concerning resource and territory defense suggests selection for specific traits related to aggression is an adaptive response to intense competition between groups of conspecifics. Copyright © 2017 Elsevier B.V. All rights reserved.

Tumor-specific detection of an optically targeted antibody combined with a quencher-conjugated neutravidin "quencher-chaser": a dual "quench and chase" strategy to improve target to nontarget ratios for molecular imaging of cancer.

PubMed

Ogawa, Mikako; Kosaka, Nobuyuki; Choyke, Peter L; Kobayashi, Hisataka

2009-01-01

In vivo molecular cancer imaging with monoclonal antibodies has great potential not only for cancer detection, but also for cancer characterization. However, the prolonged retention of intravenously injected antibody in the blood causes low target tumor-to-background ratio (TBR). Avidin has been used as a "chase" to clear the unbound, circulating biotinylated antibody and decrease the background signal. Here, we utilize a combined approach of a fluorescence resonance energy transfer (FRET) quenched antibody with an "avidin chase" to increase TBR. Trastuzumab, a humanized monoclonal antibody against human epidermal growth factor receptor type 2 (HER2), was biotinylated and conjugated with the near-infrared (NIR) fluorophore Alexa680 to synthesize Tra-Alexa680-biotin. Next, the FRET quencher, QSY-21, was conjugated to avidin, neutravidin (nAv), or streptavidin (sAv), thus creating Av-QSY21, nAv-QSY21, or sAv-QSY21 as "chasers". The fluorescence was quenched in vitro by binding Tra-Alexa680-biotin to Av-QSY21, nAv-QSY21, or sAv-QSY21. To evaluate if the injection of quencher-conjugated avidin derivatives can improve target TBR by using a dual "quench and chase" strategy, both target (3T3/HER2+) and nontarget (Balb3T3/ZsGreen) tumor-bearing mice were employed. The "FRET quench" effect induced by all the QSY21 avidin-based conjugates reduced but did not totally eliminate background signal from the blood pool. The addition of nAv-QSY21 administration increased target TBR mainly because of the "chase" effect where unbound conjugated antibody was preferentially cleared to the liver. The relatively slow clearance of unbound nAv-QSY21 leads to further reductions in background signal by leaking out of the vascular space and binding to unbound antibodies in the extravascular space of tumors, resulting in decreased nontarget tumor-to-background ratios but increased target TBR due to the "FRET quench" effect, because target-bound antibodies were internalized and could not bind to nAv-QSY21. In conclusion, the proposed "quench-and-chase" system combines two strategies, fluorescent quenching and avidin chasing, to improve target TBR and reduce nontarget TBR, which should result in both improved tumor sensitivity and improved specificity.

77 FR 45690 - Exemptions From Certain Prohibited Transaction Restrictions

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-01

... is made by a Plan fiduciary or Plan participant or IRA owner who is independent (as defined in... process; (d) A person is ``independent'' of JPMorgan Chase if the person is: (1) Not JPMorgan Chase or an... independent act of SPF as a corporate entity for business reasons which did not involve the Plan. As such, all...

Scenes of Devastation: Chasing Hawaii's Deadly Ohia Fungus | Hawaii Public

Science.gov Websites

Scenes of Devastation: Chasing Hawaii's Deadly Ohia Fungus By Molly Solomon * Mar 25, 2016 TweetShareGoogle+Email Molly Solomon Rapid Ohia Death has devastated native forests on Hawaii Island, especially in Lower Puna subdivisions like Leilani Estates. Credit Molly Solomon One of Hawai'i's oldest and most

76 FR 31955 - Jonathan and Jayne Chase; Notice of Application Accepted for Filing With the Commission, Intent...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-02

.... c. Date filed: July 23, 2010. d. Applicant: Jonathan and Jayne Chase. e. Name of Project: Troy Hydropower Project. f. Location: On the Missisquoi River, in the Town of Troy, Orleans County, Vermont. The... filing and is now ready for environmental analysis. l. Project Description: The Troy Project would...

Observations and reinterpretation of kingfisher-raptor interactions

USGS Publications Warehouse

Kirby, Ronald E.; Fuller, Mark R.

1978-01-01

Reported observations of Belted Kingfisher (Megaceryle alcyon)-raptor interactions have ranged from brief encounters where the kingfisher escaped the raptor and the hawk subsequently flew away to repeated chases (Johnson 1925, McCabe and McCabe 1928, Skinner 1928, Smith 1963). In some repetitive chases, kingfishers appeared to initiate the interaction (McCabe and McCabe 1928, Skinner 1928).

Engaging Experiential Service Learning through a Co-Curricular Club: The Chase Charlie Races

ERIC Educational Resources Information Center

Judge, Lawrence W.; Pierce, David; Petersen, Jeffrey; Bellar, David; Wanless, Elizabeth; Gilreath, Erin; Simon, Laura

2011-01-01

The efficacy of the "Chase Charlie Races" (an experiential learning activity) was demonstrated via program assessment. This was achieved via post-event evaluations of race participants and student club members, and with fitness assessments of 76 elementary students who participated in an eight-week training program. Paired sample t-tests revealed…

T-34C in flight

NASA Image and Video Library

1997-03-21

A NASA T-34C aircraft, used for safety chase, is shown flying above the Dryden Flight Research Center, Edwards, California in March 1997. The aircraft was previously used at the Lewis Research Center in propulsion experiments involving turboprop engines, and was used as a chase aircraft at Dryden for smaller and slower research projects. Chase aircraft accompany research flights for photography and video purposes, and also as support for safety and research. At Dryden, the T-34 is used mainly for smaller remotely piloted vehicles which fly slower than NASA's F-18's, used for larger scale projects. This aircraft was returned to the U.S. Navy in May of 2002. The T-34C, built by Beech, carries a crew of 2 and is nicknamed the Mentor.

CHASE Survey of Technology Needs

DTIC Science & Technology

2017-03-01

CHASE Survey of Technology Needs Shahed Enamul Quadir ECE Department University of Connecticut Storrs, CT, USA Daniel DiMase Honeywell, Inc...based on a survey conducted in late 2015. Counterfeits and Hardware Trojans have been identified as areas needing continued research and focus... survey of its advisory board and industry professionals to determine the technology needs in the area of IC counterfeits, hardware assurance

Saying the Right Word at the Right Time: Syntagmatic and Paradigmatic Interference in Sentence Production

ERIC Educational Resources Information Center

Dell, Gary S.; Oppenheim, Gary M.; Kittredge, Audrey K.

2008-01-01

Retrieving a word in a sentence requires speakers to overcome syntagmatic, as well as paradigmatic interference. When accessing "cat" in "The cat chased the string", not only are similar competitors such as "dog" and "cap" activated, but also other words in the planned sentence, such as "chase" and "string". We hypothesise that both types of…

Cheetahs, Acinonyx jubatus, balance turn capacity with pace when chasing prey

PubMed Central

Wilson, John W.; Mills, Michael G. L.; Wilson, Rory P.; Peters, Gerrit; Mills, Margaret E. J.; Speakman, John R.; Durant, Sarah M.; Bennett, Nigel C.; Marks, Nikki J.; Scantlebury, Michael

2013-01-01

Predator–prey interactions are fundamental in the evolution and structure of ecological communities. Our understanding, however, of the strategies used in pursuit and evasion remains limited. Here, we report on the hunting dynamics of the world's fastest land animal, the cheetah, Acinonyx jubatus. Using miniaturized data loggers, we recorded fine-scale movement, speed and acceleration of free-ranging cheetahs to measure how hunting dynamics relate to chasing different sized prey. Cheetahs attained hunting speeds of up to 18.94 m s−1 and accelerated up to 7.5 m s−2 with greatest angular velocities achieved during the terminal phase of the hunt. The interplay between forward and lateral acceleration during chases showed that the total forces involved in speed changes and turning were approximately constant over time but varied with prey type. Thus, rather than a simple maximum speed chase, cheetahs first accelerate to decrease the distance to their prey, before reducing speed 5–8 s from the end of the hunt, so as to facilitate rapid turns to match prey escape tactics, varying the precise strategy according to prey species. Predator and prey thus pit a fine balance of speed against manoeuvring capability in a race for survival. PMID:24004493

Cheetahs, Acinonyx jubatus, balance turn capacity with pace when chasing prey.

PubMed

Wilson, John W; Mills, Michael G L; Wilson, Rory P; Peters, Gerrit; Mills, Margaret E J; Speakman, John R; Durant, Sarah M; Bennett, Nigel C; Marks, Nikki J; Scantlebury, Michael

2013-10-23

Predator-prey interactions are fundamental in the evolution and structure of ecological communities. Our understanding, however, of the strategies used in pursuit and evasion remains limited. Here, we report on the hunting dynamics of the world's fastest land animal, the cheetah, Acinonyx jubatus. Using miniaturized data loggers, we recorded fine-scale movement, speed and acceleration of free-ranging cheetahs to measure how hunting dynamics relate to chasing different sized prey. Cheetahs attained hunting speeds of up to 18.94 m s(-1) and accelerated up to 7.5 m s(-2) with greatest angular velocities achieved during the terminal phase of the hunt. The interplay between forward and lateral acceleration during chases showed that the total forces involved in speed changes and turning were approximately constant over time but varied with prey type. Thus, rather than a simple maximum speed chase, cheetahs first accelerate to decrease the distance to their prey, before reducing speed 5-8 s from the end of the hunt, so as to facilitate rapid turns to match prey escape tactics, varying the precise strategy according to prey species. Predator and prey thus pit a fine balance of speed against manoeuvring capability in a race for survival.

A open loop guidance architecture for navigationally robust on-orbit docking

NASA Technical Reports Server (NTRS)

Chern, Hung-Sheng

1995-01-01

The development of an open-hop guidance architecture is outlined for autonomous rendezvous and docking (AR&D) missions to determine whether the Global Positioning System (GPS) can be used in place of optical sensors for relative initial position determination of the chase vehicle. Feasible command trajectories for one, two, and three impulse AR&D maneuvers are determined using constrained trajectory optimization. Early AR&D command trajectory results suggest that docking accuracies are most sensitive to vertical position errors at the initial conduction of the chase vehicle. Thus, a feasible command trajectory is based on maximizing the size of the locus of initial vertical positions for which a fixed sequence of impulses will translate the chase vehicle into the target while satisfying docking accuracy requirements. Documented accuracies are used to determine whether relative GPS can achieve the vertical position error requirements of the impulsive command trajectories. Preliminary development of a thruster management system for the Cargo Transfer Vehicle (CTV) based on optimal throttle settings is presented to complete the guidance architecture. Results show that a guidance architecture based on a two impulse maneuvers generated the best performance in terms of initial position error and total velocity change for the chase vehicle.

Global Positioning System Synchronized Active Light Autonomous Docking System

NASA Technical Reports Server (NTRS)

Howard, Richard T. (Inventor); Book, Michael L. (Inventor); Bryan, Thomas C. (Inventor); Bell, Joseph L. (Inventor)

1996-01-01

A Global Positioning System Synchronized Active Light Autonomous Docking System (GPSSALADS) for automatically docking a chase vehicle with a target vehicle comprising at least one active light emitting target which is operatively attached to the target vehicle. The target includes a three-dimensional array of concomitantly flashing lights which flash at a controlled common frequency. The GPSSALADS further comprises a visual tracking sensor operatively attached to the chase vehicle for detecting and tracking the target vehicle. Its performance is synchronized with the flash frequency of the lights by a synchronization means which is comprised of first and second internal clocks operatively connected to the active light target and visual tracking sensor, respectively, for providing timing control signals thereto, respectively. The synchronization means further includes first and second Global Positioning System receivers operatively connected to the first and second internal clocks, respectively, for repeatedly providing simultaneous synchronization pulses to the internal clocks, respectively. In addition, the GPSSALADS includes a docking process controller means which is operatively attached to the chase vehicle and is responsive to the visual tracking sensor for producing commands for the guidance and propulsion system of the chase vehicle.

Global Positioning System Synchronized Active Light Autonomous Docking System

NASA Technical Reports Server (NTRS)

Howard, Richard (Inventor)

1994-01-01

A Global Positioning System Synchronized Active Light Autonomous Docking System (GPSSALADS) for automatically docking a chase vehicle with a target vehicle comprises at least one active light emitting target which is operatively attached to the target vehicle. The target includes a three-dimensional array of concomitantly flashing lights which flash at a controlled common frequency. The GPSSALADS further comprises a visual tracking sensor operatively attached to the chase vehicle for detecting and tracking the target vehicle. Its performance is synchronized with the flash frequency of the lights by a synchronization means which is comprised of first and second internal clocks operatively connected to the active light target and visual tracking sensor, respectively, for providing timing control signals thereto, respectively. The synchronization means further includes first and second Global Positioning System receivers operatively connected to the first and second internal clocks, respectively, for repeatedly providing simultaneous synchronization pulses to the internal clocks, respectively. In addition, the GPSSALADS includes a docking process controller means which is operatively attached to the chase vehicle and is responsive to the visual tracking sensor for producing commands for the guidance and propulsion system of the chase vehicle.

Turnover of galactans and other cell wall polysaccharides during development of flax plants

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gorshkova, T.A.; Chemikosova, S.B.; Lozovaya, V.V.

1997-06-01

We investigated the synthesis and turnover of cell wall polysaccharides of the flax (Linum usitatissimum L.) plant during development of the phloem fibers. One-month-old flax plants were exposed to a 40-min pulse with {sup 14}CO{sub 2} followed by 8-h, 24-h, and 1-month periods of chase with ambient CO{sub 2}, and radioactivity in cell wall sugars was determined in various plant parts. The relative radioactivity of glucose in noncellulosic polysaccharides was the highest compared with all other cell wall sugars immediately after the pulse and decreased substantially during the subsequent chase. The relative radioactivities of the other cell wall sugars changedmore » with differing rates, indicating turnover of specific polysaccharides. Notably, after 1 month of chase there was a marked decrease in the proportional mass and total radioactivity in cell wall galactose, indicating a long-term turnover of the galactans enriched in the fiber-containing tissues. The ratio of radiolabeled xylose to arabinose also increased during the chase, indicating a turnover of arabinose-containing polymers and interconversion to xylose. The pattern of label redistribution differed between organs, indicating that the cell wall turnover processes are tissue- and cell-specific.« less

A Novel Pulse-Chase Paradigm to Visualize the Trafficking of Transport Vesicles in Neurons

NASA Astrophysics Data System (ADS)

Al-Bassam, Sarmad

In neurons transmembrane proteins are targeted to dendrites in vesicles that traffic solely within the somatodendritic compartment. How these vesicles are retained within the somatodendritic domain is unknown. Here we adapt a novel pulse chase system that allows synchronous release of exogenous transmembrane proteins from the endoplasmic reticulum using FKBP12 and Rapamycin. We demonstrate proof-of-concept and establish protein trafficking controls in incremental steps. We demonstrate the utility of this approach in studying protein trafficking and establish parameters for analysis of time-lapse images. We implement this novel pulse-chase strategy to track the movements of post-Golgi transport vesicles. Surprisingly, we found that post-Golgi vesicles carrying dendritic proteins were equally likely to enter axons and dendrites. However, once such vesicles entered the axon they very rarely moved beyond the axon initial segment, but instead either halted or reversed direction in an actin and Myosin Va-dependent manner. In contrast, vesicles carrying either an axonal or a nonspecifically localized protein only rarely halted or reversed and instead generally proceeded to the distal axon. Thus, our results are consistent with the axon initial segment behaving as a vesicle filter that mediates the differential trafficking of transport vesicles.

History Run Wild: The Alternate World of Joan Aiken's "The Wolves of Willoughby Chase" Series

ERIC Educational Resources Information Center

Dams, Isobel

2005-01-01

This article examines the historical fantasy world created by Joan Aiken in the eleven volumes of her "Wolves of Willoughby Chase" series. In particular it looks at her subversion of historical reality by the creation of an alternative yet recognisable representation of our own world, using a wide range of events, and the remoulding of aspects of…

The identification of N-linked oligosaccharides on the human CR2/Epstein-Barr virus receptor and their function in receptor metabolism, plasma membrane expression, and ligand binding.

PubMed

Weis, J J; Fearon, D T

1985-11-05

Human complement receptor type 2 (CR2) was biosynthetically labeled by pulsing SB B lymphoblastoid cells for 25 min with [35S]methionine followed by chase in the presence of excess unlabeled methionine. An Mr 134,000 polypeptide represented the major form of the receptor at the end of the pulse period, and within 1 h of chase this disappeared coincident with the appearance of the Mr 145,000 mature form of CR2. Precursor, but not mature, CR2 was sensitive to endoglycosidase H, indicating that maturation of CR2 represented processing of N-linked high mannose oligosaccharides to the complex type. The processing of precursor CR2 was impaired by monensin. In the presence of tunicamycin an Mr 111,000 form of CR2 was synthesized by SB cells, and this did not chase into either precursor or mature CR2. This Mr 111,000 form of CR2 did not incorporate [3H]glucosamine, indicating that it lacked both N- and O-linked oligosaccharide. The half-lives of mature CR2 and nonglycosylated CR2 pulse-labeled in the presence of tunicamycin were 13.8 and 2.8 h, respectively; the turnover rate of B1, a membrane protein normally lacking carbohydrate, was unaffected by the presence of the antibiotic. The percentage of pulse-labeled, nonglycosylated CR2 that was expressed at the cell surface after 1 h of chase in the presence of tunicamycin was 30%, identical to that of mature CR2 in cells chased in the absence of the antibiotic. However, after 6 h of chase there was no additional net accumulation of nonglycosylated CR2 at the plasma membrane, while the proportion of pulse-labeled mature CR2 at this site had risen to 81%. Therefore, N-linked oligosaccharides are essential for the stability of CR2 and have some role in its plasma membrane expression. In contrast, the observation that all three forms of CR2 bound to Sepharose C3 indicates that oligosaccharides are not necessary for the interaction between CR2 and its complement ligand.

Cheetah do not abandon hunts because they overheat.

PubMed

Hetem, Robyn S; Mitchell, Duncan; de Witt, Brenda A; Fick, Linda G; Meyer, Leith C R; Maloney, Shane K; Fuller, Andrea

2013-10-23

Hunting cheetah reportedly store metabolic heat during the chase and abandon chases because they overheat. Using biologging to remotely measure the body temperature (every minute) and locomotor activity (every 5 min) of four free-living cheetah, hunting spontaneously, we found that cheetah abandoned hunts, but not because they overheated. Body temperature averaged 38.4°C when the chase was terminated. Storage of metabolic heat did not compromise hunts. The increase in body temperature following a successful hunt was double that of an unsuccessful hunt (1.3°C ± 0.2°C versus 0.5°C ± 0.1°C), even though the level of activity during the hunts was similar. We propose that the increase in body temperature following a successful hunt is a stress hyperthermia, rather than an exercise-induced hyperthermia.

Cheetah do not abandon hunts because they overheat

PubMed Central

Hetem, Robyn S.; Mitchell, Duncan; de Witt, Brenda A.; Fick, Linda G.; Meyer, Leith C. R.; Maloney, Shane K.; Fuller, Andrea

2013-01-01

Hunting cheetah reportedly store metabolic heat during the chase and abandon chases because they overheat. Using biologging to remotely measure the body temperature (every minute) and locomotor activity (every 5 min) of four free-living cheetah, hunting spontaneously, we found that cheetah abandoned hunts, but not because they overheated. Body temperature averaged 38.4°C when the chase was terminated. Storage of metabolic heat did not compromise hunts. The increase in body temperature following a successful hunt was double that of an unsuccessful hunt (1.3°C ± 0.2°C versus 0.5°C ± 0.1°C), even though the level of activity during the hunts was similar. We propose that the increase in body temperature following a successful hunt is a stress hyperthermia, rather than an exercise-induced hyperthermia. PMID:23883578

Douglas Lowy and Nirali Shah discuss advancements in cancer treatment at the second annual Chasing Cancer Summit | Center for Cancer Research

Cancer.gov

On Monday, September 18, 2017, the second annual Chasing Cancer Summit was held at the Washington Post headquarters in downtown Washington, D.C. The live event brought together a group of experts, including CCR’s Douglas Lowy, M.D., and Nirali Shah, M.D., for discussions on the latest developments in cancer detection and treatment.  Read more...

Ex vivo preservation and expansion of human limbal epithelial stem cells on amniotic membrane cultures.

PubMed

Meller, D; Pires, R T F; Tseng, S C G

2002-04-01

Amniotic membrane (AM) transplantation effectively expands the remaining limbal epithelial stem cells in patients with partial limbal stem cell deficiency. The authors investigated whether this action could be produced ex vivo. The outgrowth rate on AM was compared among explants derived from human limbus, peripheral cornea, and central cornea. For outgrowth of human limbal epithelial cells (HLEC), cell cycle kinetics were measured by BrdU labelling for 1 or 7 days, of which the latter was also chased in primary cultures, secondary 3T3 fibroblast cultures, and in athymic Balb/c mice following a brief treatment with a phorbol ester. Epithelial morphology was studied by histology and transmission electron microscopy, and phenotype was defined by immunostaining with monoclonal antibodies to keratins and mucins. Outgrowth rate was 0/22 (0%) and 2/24 (8.3%) for central and peripheral corneal explants, respectively, but was 77/80 (96.2%) for limbal explants (p <0.0001). 24 hour BrdU labelling showed a uniformly low (that is, less than 5%) labelling index in 65% of the limbal explants, but a mixed pattern with areas showing a high (that is, more than 40%) labelling index in 35% of limbal explants, and in all (100%) peripheral corneal explants. Continuous BrdU labelling for 7 days detected a high labelling index in 61.5% of the limbal explants with the remainder still retaining a low labelling index. A number of label retaining cells were noted after 7 day labelling followed by 14 days of chase in primary culture or by 21 days of chase after transplantation to 3T3 fibroblast feeder layers. After exposure to phorbol 12-myristate 13-acetate for 24 hours and 7 day labelling, HLEC transplanted in athymic mice still showed a number of label retaining basal cells after 9 days of chase. HLEC cultured on AM were strongly positive for K14 keratin and MUC4 and slightly positive in suprabasal cells for K3 keratin but negative for K12 keratin, AMEM2, and MUC5AC. After subcutaneous implantation in athymic mice, the resultant epithelium was markedly stratified and the basal epithelial cells were strongly positive for K14 keratin, while the suprabasal epithelial cells were strongly positive for K3 keratin and MUC4, and the entire epithelium was negative for K12 keratin and MUC5A/C. These data support the notion that AM cultures preferentially preserve and expand limbal epithelial stem cells that retain their in vivo properties of slow cycling, label retaining, and undifferentiation. This finding supports the feasibility of ex vivo expansion of limbal epithelial stem cells for treating patients with total limbal stem cell deficiency using a small amount of donor limbal tissue.

Fox Chase Cancer Center's Genitourinary Division: a national resource for research, innovation and patient care.

PubMed

Uzzo, Robert G; Horwitz, Eric M; Plimack, Elizabeth R

2016-04-01

Founded in 1904, Fox Chase Cancer Center remains committed to its mission. It is one of 41 centers in the country designated as a Comprehensive Cancer Center by the National Cancer Institute, is a founding member of the National Comprehensive Cancer Network, holds the magnet designation for nursing excellence, is one of the first to establish a family cancer risk assessment program, and has achieved national distinction because of the scientific discoveries made there that have advanced clinical care. Two of its researchers have won Nobel prizes. The Genitourinary Division is nationally recognized and viewed as one of the top driving forces behind the growth of Fox Chase due to its commitment to initiating and participating in clinical trials, its prolific contributions to peer-reviewed publications and presentations at scientific meetings, its innovations in therapies and treatment strategies, and its commitment to bringing cutting-edge therapies to patients.

STS-4 landing at Edwards Air Foce Base, California

NASA Technical Reports Server (NTRS)

1982-01-01

STS-4 landing at Edwards Air Foce Base, California. Actor Roy Rogers with Astronauts Jerry L. Ross, left, and Guy S. Gardner at Edwards for the STS-4 landing on July 1, 1982. Also present (behind Gardner at extreme right) was former Astronaut Edwin E. Aldrin, Jr. (33226); President Ronald Reagan and First Lady Nancy Reagan meet Astronauts Thomas K. Mattingly, II., right, and Henry W. Hartsfield, Jr., after the landing of the Columbia at Edwards (33227,33230); Space Shuttle Columbia, followed by two T-38 chase planes, touches down on Edwards Air Force Base's Runway 22 to complete mission. In this view, one chase plane appears to be directly above and behind the Columbia, whose nose wheels have not yet touched ground. The other plane appears to be further up front (33228); The rear wheels of the Columbia touch down on the Edwards AFB runway. There are no chase planes in sight in this photo (33229).

How do gamblers end gambling: longitudinal analysis of Internet gambling behaviors prior to account closure due to gambling related problems.

PubMed

Xuan, Ziming; Shaffer, Howard

2009-06-01

To examine behavioral patterns of actual Internet gamblers who experienced gambling-related problems and voluntarily closed their accounts. A nested case-control design was used to compare gamblers who closed their accounts because of gambling problems to those who maintained open accounts. Actual play patterns of in vivo Internet gamblers who subscribed to an Internet gambling site. 226 gamblers who closed accounts due to gambling problems were selected from a cohort of 47,603 Internet gamblers who subscribed to an Internet gambling site during February 2005; 226 matched-case controls were selected from the group of gamblers who did not close their accounts. Daily aggregates of behavioral data were collected during an 18-month study period. Main outcomes of interest were daily aggregates of stake, odds, and net loss, which were standardized by the daily aggregate number of bets. We also examined the number of bets to measure trajectory of gambling frequency. Account closers due to gambling problems experienced increasing monetary loss as the time to closure approached; they also increased their stake per bet. Yet they did not chase longer odds; their choices of wagers were more probabilistically conservative (i.e., short odds) compared with the controls. The changes of monetary involvement and risk preference occurred concurrently during the last few days prior to voluntary closing. Our finding of an involvement-seeking yet risk-averse tendency among self-identified problem gamblers challenges the notion that problem gamblers seek "long odds" during "chasing."

Coplanar tail-chase aerial combat as a differential game

NASA Technical Reports Server (NTRS)

Merz, A. W.; Hague, D. S.

1977-01-01

A reduced-order version of the one-on-one aerial combat problem is studied as a pursuit-evasion differential game. The coplanar motion takes place at given speeds and given maximum available turn rates, and is described by three state equations which are equivalent to the range, bearing, and heading of one aircraft relative to the other. The purpose of the study is to determine those relative geometries from which either aircraft can be guaranteed a win, regardless of the maneuver strategies of the other. Termination is specified by the tail-chase geometry, at which time the roles of pursuer and evader are known. The roles are found in general, together with the associated optimal turn maneuvers, by solution of the differential game of kind. For the numerical parameters chosen, neither aircraft can win from the majority of possible initial conditions if the other turns optimally in certain critical geometries.

NO2 DOAS Measurements of Traffic Emissions by Chasing Cars

NASA Astrophysics Data System (ADS)

Zhu, Ying; Lipkowitsch, Ivo; Chan, Ka Lok; Bräu, Melanie; Wenig, Mark

2016-04-01

On this poster we present NO2 measurements using a Cavity-Enhanced DOAS on a measurement bus which we used to chase other vehicles to measure their NO2 emissions. Emissions of nitrogen oxides from on-road vehicles have received highly attention recently due to the increasing trend of ambient NOx level. It is particularly important to identify and quantify the direct emission and secondary formation of NO2 contributed by traffic emissions, in order to study the impact to the local air quality. We sampled on-road emissions in different environments and different driving conditions (e.g. urban, highway, different speeds). We analyse the data set in terms of spatial and temporal variability to search for temporal and spatial patterns. We present mean values sorted for different vehicle types, distance to the target car and travelling speeds to provide an emission data base from this measurement study.

Modeling Syntax for Parsing and Translation

DTIC Science & Technology

2003-12-15

20 CHAPTER 2. MONOLINGUAL PROBABILISTIC PARSING a the D cat snake D S O chased S O ran SS Mary O Figure 2.1: Part of a dictionary . the cat S chased S O...along with their training algorithms: a monolingual gen- erative model of sentence structure, and a model of the relationship between the structure of a...tasks of monolingual parsing and word-level bilingual corpus alignment, they are demonstrated in two additional applications. First, a new statistical

Effects of repeated simulated removal activities on feral swine movements and space use

USGS Publications Warehouse

Fischer, Justin W.; McMurtry , Dan; Blass, Chad R.; Walter, W. David; Beringer, Jeff; VerCauterren, Kurt C.

2016-01-01

Abundance and distribution of feral swine (Sus scrofa) in the USA have increased dramatically during the last 30 years. Effective measures are needed to control and eradicate feral swine populations without displacing animals over wider areas. Our objective was to investigate effects of repeated simulated removal activities on feral swine movements and space use. We analyzed location data from 21 feral swine that we fitted with Global Positioning System harnesses in southern MO, USA. Various removal activities were applied over time to eight feral swine before lethal removal, including trapped-and-released, chased with dogs, chased with hunter, and chased with helicopter. We found that core space-use areas were reduced following the first removal activity, whereas overall space-use areas and diurnal movement distances increased following the second removal activity. Mean geographic centroid shifts did not differ between pre- and post-periods for either the first or second removal activities. Our information on feral swine movements and space use precipitated by human removal activities, such as hunting, trapping, and chasing with dogs, helps fill a knowledge void and will aid wildlife managers. Strategies to optimize management are needed to reduce feral swine populations while preventing enlarged home ranges and displacing individuals, which could lead to increased disease transmission risk and human-feral swine conflict in adjacent areas.

Detection of BrdU-label Retaining Cells in the Lacrimal Gland: Implications for Tissue Repair

PubMed Central

You, Samantha; Tariq, Ayesha; Kublin, Claire L.; Zoukhri, Driss

2011-01-01

The purpose of the present study was to determine if the lacrimal gland contains 5-bromo-2’-deoxyuridine (BrdU)-label retaining cells and if they are involved in tissue repair. Animals were pulsed daily with BrdU injections for 7 consecutive days. After a chase period of 2, 4, or 12 weeks, the animals were sacrificed and the lacrimal glands were removed and processed for BrdU immunostaining. In another series of experiments, the lacrimal glands of 12-week chased animals were either left untreated or were injected with interleukin 1 (IL-1) to induce injury. Two and half day post-injection, the lacrimal glands were removed and processed for BrdU immunostaining. After 2 and 4 week of chase period, a substantial number of lacrimal gland cells were BrdU+ (11.98 ± 1.84 and 7.95 ± 1.83 BrdU+ cells/mm2, respectively). After 12 weeks of chase, there was a 97% decline in the number of BrdU+ cells (0.38 ± 0.06 BrdU+ cells/mm2), suggesting that these BrdU-label retaining cells may represent slow-cycling adult stem/progenitor cells. In support of this hypothesis, the number of BrdU labeled cells increased over 7-fold during repair of the lacrimal gland (control: 0.41 ± 0.09 BrdU+ cells/mm2, injured: 2.91 ± 0.62 BrdU+ cells/mm2). Furthermore, during repair, among BrdU+ cells 58.2 ± 3.6 % were acinar cells, 26.4 ± 4.1% were myoepithelial cells, 0.4 ± 0.4% were ductal cells, and 15.0 ± 3.0% were stromal cells. We conclude that the murine lacrimal gland contains BrdU-label retaining cells that are mobilized following injury to generate acinar, myoepithelial and ductal cells. PMID:22101331

Machine Learning

DTIC Science & Technology

1990-04-01

DTIC i.LE COPY RADC-TR-90-25 Final Technical Report April 1990 MACHINE LEARNING The MITRE Corporation Melissa P. Chase Cs) CTIC ’- CT E 71 IN 2 11990...S. FUNDING NUMBERS MACHINE LEARNING C - F19628-89-C-0001 PE - 62702F PR - MOlE S. AUTHO(S) TA - 79 Melissa P. Chase WUT - 80 S. PERFORMING...341.280.5500 pm I " Aw Sig rill Ia 2110-01 SECTION 1 INTRODUCTION 1.1 BACKGROUND Research in machine learning has taken two directions in the problem of

National Program for Inspection of Non-Federal Dams. Chase Pond Dam (NH 00255), NHWRB Number 253.02, Merrimack River Basin, Wilmot, New Hampshire. Phase I Inspection Report.

DTIC Science & Technology

1980-03-01

STANDAROS-1963-A L ~.°.. o...... 1....MERRIMACK RIVER BASIN -!. WILMOT , NEW HAMPSHIRE ’,- CHASE POND DAM NH 00255 NHWRB NO. 253.02 r PHASE I...Continue on fewsorsp side #0 .o..oemay and Ientify by black Muthot) - DAMS, NSPECTION, PAM S’AFETY, Merrimack River Basin. * Wilmot , New Hampshire...MERRIMACK RIVER BASIN R WILMOT , NEW HAMPSHIRE - - PHASE I INSPECTION REPORT NATIONAL DAM INSPECTION PROGRAM :: : I

Application of curative therapy in the ward. 1920.

PubMed

Marble, Henry Chase

2009-06-01

This Classic article is a reprint of the original work by Henry Chase Marble, Application of Curative Therapy in the Ward. An accompanying biographical sketch on Henry Chase Marble, MD, is available at DOI 10.1007/s11999-009-0789-7 . The Classic Article is (c)1920 by the Journal of Bone and Joint Surgery, Inc. and is reprinted with permission from Marble HC. Application of curative therapy in the ward. J Bone Joint Surg Am. 1920;2:136-138.

The F-18 simulator at NASA's Dryden Flight Research Center, Edwards, California

NASA Image and Video Library

2004-10-04

The F-18 simulator at NASA's Dryden Flight Research Center, Edwards, California. Simulators offer a safe and economical alternative to actual flights to gather data, as well as being excellent facilities for pilot practice and training. The F-18 Hornet is used primarily as a safety chase and mission support aircraft at NASA's Dryden Flight Research Center, Edwards, California. As support aircraft, the F-18's are used for safety chase, pilot proficiency, aerial photography and other mission support functions.

Responding to the Novel: Reading, Writing, and Research.

ERIC Educational Resources Information Center

Polette, Nancy

1991-01-01

Discusses approaches to novel studies for children and youth and provides a fully developed novel study based on "The Wolves of Willoughby Chase" by Joan Aiken. Prereading activities are described, a booktalk is provided, prereading journal suggestions are given, postreading activities are described, and related reading titles are…

Pattern production through a chiral chasing mechanism

NASA Astrophysics Data System (ADS)

Woolley, Thomas E.

2017-09-01

Recent experiments on zebrafish pigmentation suggests that their typical black and white striped skin pattern is made up of a number of interacting chromatophore families. Specifically, two of these cell families have been shown to interact through a nonlocal chasing mechanism, which has previously been modeled using integro-differential equations. We extend this framework to include the experimentally observed fact that the cells often exhibit chiral movement, in that the cells chase, and run away, at angles different to the line connecting their centers. This framework is simplified through the use of multiple small limits leading to a coupled set of partial differential equations which are amenable to Fourier analysis. This analysis results in the production of dispersion relations and necessary conditions for a patterning instability to occur. Beyond the theoretical development and the production of new pattern planiforms we are able to corroborate the experimental hypothesis that the global pigmentation patterns can be dependent on the chirality of the chromatophores.

Rise of a Cybered Westphalian Age

DTIC Science & Technology

2011-01-01

a Cybered Westphalian Age Strategic Studies Quarterly ♦ Spring 2011 [ 39 ] their societies, into critical assets of families , banks, townships...women in positions of power and chase P2P porn sites and dissidents internally. The Chinese bureaucracy will refuse to agree to international

Dissociating the detection of intentionality from animacy in the right posterior superior temporal sulcus

PubMed Central

Gao, Tao; Scholl, Brian J.; McCarthy, Gregory

2012-01-01

Certain motion patterns can cause even simple geometric shapes to be perceived as animate. Viewing such displays evokes strong activation in temporoparietal cortex, including areas in and near the (predominantly right) posterior superior temporal sulcus (pSTS). These brain regions are sensitive to socially relevant information, but the nature of the social information represented in pSTS is unclear. For example, previous studies have been unable to explore the perception of shifting intentions, beyond animacy. This is due in part to the ubiquitous use of complex displays that combine several types of social information, with little ability to control lower-level visual cues. Here we address this challenge by manipulating intentionality with parametric precision while holding cues to animacy constant. Human subjects were exposed to a “wavering wolf” display, in which one item (the ‘wolf’) chased continuously, but its goal (i.e. the sheep) frequently switched among other shapes. By contrasting this with three other control displays, we find that the wolf’s changing intentions gave rise to strong selective activation in the right pSTS, compared with (1) a wolf that chases with a single unchanging intention; (2) very similar patterns of motion (and motion change) that are not perceived as goal-directed; and (3) abrupt onsets and offsets of moving objects. These results demonstrate in an especially well controlled manner that right pSTS is involved in social perception, beyond physical properties such as motion energy and salience. More importantly, these results demonstrate for the first time that this region represents perceived intentions, beyond animacy. PMID:23055497

Evaluation of reversed-phase nano liquid chromatography conditions by using reversed-phase thin layer chromatography based on Hansen solubility parameters for the analysis of amphiphilic glycosylsphingolipid transformations.

PubMed

Kanie, Yoshimi; Taniuchi, Mizuki; Kanie, Osamu

2018-01-26

Pulse chase analysis is often used in investigating dynamics of cellular substances. Fluorescently labeled lactosyl sphingosine molecule is useful in chasing its transformation, however the analysis of such metabolites in attomole level is of extreme difficult due to the presence of large amount of endogenous amphiphilic molecules such as glycosphingolipids, sphingomyerin, and glycerophospholipids. Nano LC suites for analyzing the attomole scale metabolites, therefore removal of endogenous substances prior to nano LC and finding appropriate nano LC conditions are necessary. Thus, we focused on the solubility of fluorescent BODIPY-labeled lactosylsphingosine (Lac-Sph-BODIPY) to identify suitable solvents to remove endogenous compounds. In this study, we evaluated solvents by using C18 thin layer chromatography (RP TLC). The mobility (R f ) of Lac-Sph-BODIPY against several solvent mixtures on RP TLC were plotted against polarity and hydrogen bonding capability followed by Hansen solubility parameters (HSPs). The optimum solvent mixture with R f  = 0.3 ± 0.1 was chosen for elimination of endogenous phospholipids on a ZrO 2 -SiO 2 cartridge column and subsequent separation by nano LC. Efficient removal of endogenous phospholipids was demonstrated, and good resolution in nano LC analysis of Lac-Sph-BODIPY extracted from Chinese hamster ovary (CHO)-K1 cells was achieved. It was also shown that the amount of exogenously added compound was important in the investigation of metabolites using cultured cells. Copyright © 2017 Elsevier B.V. All rights reserved.

Long-Term Exposure to Primary Traffic Pollutants and Lung Function in Children: Cross-Sectional Study and Meta-Analysis.

PubMed

Barone-Adesi, Francesco; Dent, Jennifer E; Dajnak, David; Beevers, Sean; Anderson, H Ross; Kelly, Frank J; Cook, Derek G; Whincup, Peter H

2015-01-01

There is widespread concern about the possible health effects of traffic-related air pollution. Nitrogen dioxide (NO2) is a convenient marker of primary pollution. We investigated the associations between lung function and current residential exposure to a range of air pollutants (particularly NO2, NO, NOx and particulate matter) in London children. Moreover, we placed the results for NO2 in context with a meta-analysis of published estimates of the association. Associations between primary traffic pollutants and lung function were investigated in 4884 children aged 9-10 years who participated in the Child Heart and Health Study in England (CHASE). A systematic literature search identified 13 studies eligible for inclusion in a meta-analysis. We combined results from the meta-analysis with the distribution of the values of FEV1 in CHASE to estimate the prevalence of children with abnormal lung function (FEV1<80% of predicted value) expected under different scenarios of NO2 exposure. In CHASE, there were non-significant inverse associations between all pollutants except ozone and both FEV1 and FVC. In the meta-analysis, a 10 μg/m3 increase in NO2 was associated with an 8 ml lower FEV1 (95% CI: -14 to -1 ml; p: 0.016). The observed effect was not modified by a reported asthma diagnosis. On the basis of these results, a 10 μg/m3 increase in NO2 level would translate into a 7% (95% CI: 4% to 12%) increase of the prevalence of children with abnormal lung function. Exposure to traffic pollution may cause a small overall reduction in lung function and increase the prevalence of children with clinically relevant declines in lung function.

Long-term US energy outlook

DOE Office of Scientific and Technical Information (OSTI.GOV)

Friesen, G.

Chase Econometrics summarizes the assumptions underlying long-term US energy forecasts. To illustrate the uncertainty involved in forecasting for the period to the year 2000, they compare Chase Econometrics forecasts with some recent projections prepared by the DOE Office of Policy, Planning and Analysis for the annual National Energy Policy Plan supplement. Scenario B, the mid-range reference case, is emphasized. The purpose of providing Scenario B as well as Scenarios A and C as alternate cases is to show the sensitivity of oil price projections to small swings in energy demand. 4 tables.

Management of the Air Force Backlog of Maintenance and Repair.

DTIC Science & Technology

1983-09-01

1. Chase, Richard B., and Nicholas J. Aquilano. Production and Operations Management. Homewood IL: Richard D. Irwin, Inc., 1981. - 2. Descartes , Rene ...addition to the request, the apparently out-of-control growth of the BMAR is in itself worthy of study. Descartes said, "The end of study should be to

Dramatic Improvements in Beach Water Quality Following Gull Removal

EPA Science Inventory

Gulls are often cited as important contributors of fecal contamination to surface waters, and some recreational beaches have used gull control measures to improve microbial water quality. In this study, gulls were chased from a Lake Michigan beach using specially trained dogs, a...

Resin bleed improvement on surface mount semiconductor device

NASA Astrophysics Data System (ADS)

Rajoo, Indra Kumar; Tahir, Suraya Mohd; Aziz, Faieza Abdul; Shamsul Anuar, Mohd

2018-04-01

Resin bleed is a transparent layer of epoxy compound which occurs during molding process but is difficult to be detected after the molding process. Resin bleed on the lead on the unit from the focused package, SOD123, can cause solderability failure at end customer. This failed unit from the customer will be considered as a customer complaint. Generally, the semiconductor company has to perform visual inspection after the plating process to detect resin bleed. Mold chase with excess hole, split cavity & stepped design ejector pin hole have been found to be the major root cause of resin bleed in this company. The modifications of the mold chase, changing of split cavity to solid cavity and re-design of the ejector pin proposed were derived after a detailed study & analysis conducted to arrive at these solutions. The solutions proposed have yield good results during the pilot run with zero (0) occurrence of resin bleed for 3 consecutive months.

An Unsupervised Approach for Extraction of Blood Vessels from Fundus Images.

PubMed

Dash, Jyotiprava; Bhoi, Nilamani

2018-04-26

Pathological disorders may happen due to small changes in retinal blood vessels which may later turn into blindness. Hence, the accurate segmentation of blood vessels is becoming a challenging task for pathological analysis. This paper offers an unsupervised recursive method for extraction of blood vessels from ophthalmoscope images. First, a vessel-enhanced image is generated with the help of gamma correction and contrast-limited adaptive histogram equalization (CLAHE). Next, the vessels are extracted iteratively by applying an adaptive thresholding technique. At last, a final vessel segmented image is produced by applying a morphological cleaning operation. Evaluations are accompanied on the publicly available digital retinal images for vessel extraction (DRIVE) and Child Heart And Health Study in England (CHASE_DB1) databases using nine different measurements. The proposed method achieves average accuracies of 0.957 and 0.952 on DRIVE and CHASE_DB1 databases respectively.

Constraining chameleon field theories using the GammeV afterglow experiments

DOE Office of Scientific and Technical Information (OSTI.GOV)

Upadhye, A.; /Chicago U., EFI /KICP, Chicago; Steffen, J.H.

2009-11-01

The GammeV experiment has constrained the couplings of chameleon scalar fields to matter and photons. Here we present a detailed calculation of the chameleon afterglow rate underlying these constraints. The dependence of GammeV constraints on various assumptions in the calculation is studied. We discuss GammeV-CHASE, a second-generation GammeV experiment, which will improve upon GammeV in several major ways. Using our calculation of the chameleon afterglow rate, we forecast model-independent constraints achievable by GammeV-CHASE. We then apply these constraints to a variety of chameleon models, including quartic chameleons and chameleon dark energy models. The new experiment will be able to probemore » a large region of parameter space that is beyond the reach of current tests, such as fifth force searches, constraints on the dimming of distant astrophysical objects, and bounds on the variation of the fine structure constant.« less

Biosynthesis, targeting, and processing of lysosomal proteins: pulse-chase labeling and immune precipitation.

PubMed

Pohl, Sandra; Hasilik, Andrej

2015-01-01

Incorporation of radioactive precursors of amino acids and/or modifier groups into proteins, isolation and sizing of polypeptide species of interest, and finally their detection and characterization provide a robust handle to examine the life cycle and varied modifications of any protein. A prerequisite in application of these techniques to lysosomal enzymes is the availability of an avid and specific antibody, because lysosomal proteins represent a very minor fraction of the cellular protein and must be purified without a significant loss many 1000-fold as conveniently as possible. Pulse-chase labeling and good knowledge on organelle-specific modifications of lysosomal proteins may enhance the information that can be obtained from such experiments. We describe procedures for pulse-chase labeling experiments that have proven to work with a commercially available antibody against a mouse and a human lysosomal protease and can be used as a reference in establishing the technique in any laboratory that has an access to a certified isotope facility and the knowledge to handle radioactivity safely. We discuss the crucial steps and refer to alternatives described in the literature. The present model protein cathepsin Z is synthesized as a larger proenzyme that contains two N-linked oligosaccharides and matures to a shorter single chain enzyme retaining the processed oligosaccharides. A pulse-chase experiment demonstrates the conversion of the precursor into the mature form. In addition, results on deglycosylation of metabolically labeled cathepsin Z are shown and the alterations in the apparent size of the glycopeptides are explained. Copyright © 2015 Elsevier Inc. All rights reserved.

Measure Guideline: Summary of Interior Ducts in New Construction, Including an Efficient, Affordable Method to Install Fur-Down Interior Ducts

DOE Office of Scientific and Technical Information (OSTI.GOV)

Beal, D.; McIlvaine , J.; Fonorow, K.

2011-11-01

This document illustrates guidelines for the efficient installation of interior duct systems in new housing, including the fur-up chase method, the fur-down chase method, and interior ducts positioned in sealed attics or sealed crawl spaces. This document illustrates guidelines for the efficient installation of interior duct systems in new housing. Interior ducts result from bringing the duct work inside a home's thermal and air barrier. Architects, designers, builders, and new home buyers should thoroughly investigate any opportunity for energy savings that is as easy to implement during construction, such as the opportunity to construct interior duct work. In addition tomore » enhanced energy efficiency, interior ductwork results in other important advantages, such as improved indoor air quality, increased system durability and increased homeowner comfort. While the advantages of well-designed and constructed interior duct systems are recognized, the implementation of this approach has not gained a significant market acceptance. This guideline describes a variety of methods to create interior ducts including the fur-up chase method, the fur-down chase method, and interior ducts positioned in sealed attics or sealed crawl spaces. As communication of the intent of an interior duct system, and collaboration on its construction are paramount to success, this guideline details the critical design, planning, construction, inspection, and verification steps that must be taken. Involved in this process are individuals from the design team; sales/marketing team; and mechanical, insulation, plumbing, electrical, framing, drywall and solar contractors.« less

Cultivating Deductive Thinking with Angle Chasing

ERIC Educational Resources Information Center

Edwards, Michael todd; Quinlan, James; Harper, Suzanne R.; Cox, Dana C.; Phelps, Steve

2014-01-01

Despite Common Core State Standards for Mathematics (CCSSI 2010) recommendations, too often students' introduction to proof consists of the study of formal axiomatic systems--for example, triangle congruence proofs--typically in an introductory geometry course with no connection back to previous work in earlier algebra courses. Van Hiele…

All the King's Men.

ERIC Educational Resources Information Center

Seeberg, Mark S.

1980-01-01

Reports on a four-year-old, team-taught secondary interdisciplinary program that combined English, social studies, biology, and geometry. The course was organized into three phases: (1) the "Paper Chase," teaching learning skills; (2) "Welcome to the Monkey House," which addressed fundamental human issues; and (3) "Phase Out," or personal…

"Chasing a Passion": First-Generation College Graduates at Work

ERIC Educational Resources Information Center

Olson, Joann S.

2016-01-01

Purpose: The purpose of this paper is to describe the college-to-work transition as experienced by first-generation college (FGC) graduates. First-generation graduates are often adjusting to workplaces that are significantly different from parents' work environments. Design/methodology/approach: This phenomenological study explored the…

Characterization of the Photon Counting CHASE Jr., Chip Built in a 40-nm CMOS Process With a Charge Sharing Correction Algorithm Using a Collimated X-Ray Beam

DOE Office of Scientific and Technical Information (OSTI.GOV)

Krzyżanowska, A.; Deptuch, G. W.; Maj, P.

This paper presents the detailed characterization of a single photon counting chip, named CHASE Jr., built in a CMOS 40-nm process, operating with synchrotron radiation. The chip utilizes an on-chip implementation of the C8P1 algorithm. The algorithm eliminates the charge sharing related uncertainties, namely, the dependence of the number of registered photons on the discriminator’s threshold, set for monochromatic irradiation, and errors in the assignment of an event to a certain pixel. The article presents a short description of the algorithm as well as the architecture of the CHASE Jr., chip. The analog and digital functionalities, allowing for proper operationmore » of the C8P1 algorithm are described, namely, an offset correction for two discriminators independently, two-stage gain correction, and different operation modes of the digital blocks. The results of tests of the C8P1 operation are presented for the chip bump bonded to a silicon sensor and exposed to the 3.5- μm -wide pencil beam of 8-keV photons of synchrotron radiation. It was studied how sensitive the algorithm performance is to the chip settings, as well as the uniformity of parameters of the analog front-end blocks. Presented results prove that the C8P1 algorithm enables counting all photons hitting the detector in between readout channels and retrieving the actual photon energy.« less

Artificial selection for food colour preferences.

PubMed

Cole, Gemma L; Endler, John A

2015-04-07

Colour is an important factor in food detection and acquisition by animals using visually based foraging. Colour can be used to identify the suitability of a food source or improve the efficiency of food detection, and can even be linked to mate choice. Food colour preferences are known to exist, but whether these preferences are heritable and how these preferences evolve is unknown. Using the freshwater fish Poecilia reticulata, we artificially selected for chase behaviour towards two different-coloured moving stimuli: red and blue spots. A response to selection was only seen for chase behaviours towards the red, with realized heritabilities ranging from 0.25 to 0.30. Despite intense selection, no significant chase response was recorded for the blue-selected lines. This lack of response may be due to the motion-detection mechanism in the guppy visual system and may have novel implications for the evolvability of responses to colour-related signals. The behavioural response to several colours after five generations of selection suggests that the colour opponency system of the fish may regulate the response to selection. © 2015 The Author(s) Published by the Royal Society. All rights reserved.

Artificial selection for food colour preferences

PubMed Central

Cole, Gemma L.; Endler, John A.

2015-01-01

Colour is an important factor in food detection and acquisition by animals using visually based foraging. Colour can be used to identify the suitability of a food source or improve the efficiency of food detection, and can even be linked to mate choice. Food colour preferences are known to exist, but whether these preferences are heritable and how these preferences evolve is unknown. Using the freshwater fish Poecilia reticulata, we artificially selected for chase behaviour towards two different-coloured moving stimuli: red and blue spots. A response to selection was only seen for chase behaviours towards the red, with realized heritabilities ranging from 0.25 to 0.30. Despite intense selection, no significant chase response was recorded for the blue-selected lines. This lack of response may be due to the motion-detection mechanism in the guppy visual system and may have novel implications for the evolvability of responses to colour-related signals. The behavioural response to several colours after five generations of selection suggests that the colour opponency system of the fish may regulate the response to selection. PMID:25740894

Chunks in expert memory: evidence for the magical number four ... or is it two?

PubMed

Gobet, Fernand; Clarkson, Gary

2004-11-01

This study aims to test the divergent predictions of the chunking theory (Chase & Simon, 1973) and template theory (Gobet & Simon, 1996a, 2000) with respect to the number of chunks held in visual short-term memory and the size of chunks used by experts. We presented game and random chessboards in both a copy and a recall task. In a within-subject design, the stimuli were displayed using two presentation media: (a) physical board and pieces, as in Chase and Simon's (1973) study; and (b) a computer display, as in Gobet and Simon's (1998) study. Results show that, in most cases, no more than three chunks were replaced in the recall task, as predicted by template theory. In addition, with game positions in the computer condition, chess Masters replaced very large chunks (up to 15 pieces), again in line with template theory. Overall, the results suggest that the original chunking theory overestimated short-term memory capacity and underestimated the size of chunks used, in particular with Masters. They also suggest that Cowan's (2001) proposal that STM holds four chunks may be an overestimate.

What Contribution Can General Semantics Make to the Communication Arts?

ERIC Educational Resources Information Center

Maynard, Harry E.

Discussion in this paper is given to some studies and texts devoted to the study of general semantics, which is defined as the study of language operations in real human contexts with emphasis on the human consequences of these operations. Mentioned are (1) books by S. I. Hayakawa, Wendell Johnson, Irving J. Lee, and Stuart Chase; (2) lesson plans…

Using a Computer Game to Reinforce Skills in Addition Basic Facts in Second Grade.

ERIC Educational Resources Information Center

Kraus, William H.

1981-01-01

A computer-generated game called Fish Chase was developed to present drill-and-practice exercises on addition facts. The subjects of the study were 19 second-grade pupils. The results indicate a computer game can be used effectively to increase proficiency with basic facts. (MP)

77 FR 70141 - Application(s) for Duty-Free Entry of Scientific Instruments

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-23

... Institute, 4000 Jones Bridge Rd., Chevy Chase, MD 20815. Instrument: Micro-litre and nanolitre dispensing...-litre and nanolitre dispensing system. Manufacturer: TTP Labtech Ltd, United Kingdom. Intended Use: The...: The instrument will be used to study biomaterials such as starches, lignin, and proteins, and compare...

The CHilean Automatic Supernova sEarch (CHASE)

NASA Astrophysics Data System (ADS)

Pignata, G.; Maza, J.; Hamuy, M.; Antezana, R.; Gonzales, L.

2009-05-01

One of the most important challenges in modern cosmology will be to figure out the origin of the dark energy, to measure its equation of state and the time rate with which it changes (described by parameters w and w'). The measurement of these parameters will require high levels of accuracy in the Supernova (SN) Type Ia distances and various sources of systematic error such as reddening corrections and possible evolution in the SNcharacteristics which could couple with redshift and mimic the cosmological signal of interest. Fortunately, these concerns can be fully addressed through the comprehensive study of SNe in the local (z < 0.05) universe. Although Type II plateau SNe are not as luminous as SNe Ia, they afford two important, independent routes to cosmological distances using the Expanding Photosphere Method and the Standardized Candle Method. To assess the performance of these techniques a nearby sample of Type II SNe is necessary. With the purpose of addressing these issues the Millennium Center for Supernova Studies (MCSS) is teaming up with the Carnegie Supernova Project (CSP) to carry out an optical and near infrared (photometry, spectroscopy and polarimetry) follow up of nearby SNe. Unfortunately, the majority of the SNe observed by the MCSS and the CSP are discovered by searches carried out from the northern hemisphere. This entails a number of observational difficulties, in particular, it reduces the number of SNe for which the follow-up starts at very early epochs. The aim of the CHASE project is to remove this search bias by discovering young Southern SNe that will be extensively observed by the MCSS and the CSP. In the first nine-months of operation, CHASE has discovered two SNe: SN007oc (CBET 1114) and SN007pl (CBET 1130), thus demonstrating the feasibility of the survey.

Simulated predator stimuli reduce brain cell proliferation in two electric fish species, Brachyhypopomus gauderio and Apteronotus leptorhynchus.

PubMed

Dunlap, Kent D; Keane, Geoffrey; Ragazzi, Michael; Lasky, Elise; Salazar, Vielka L

2017-07-01

The brain structure of many animals is influenced by their predators, but the cellular processes underlying this brain plasticity are not well understood. Previous studies showed that electric fish ( Brachyhypopomus occidentalis ) naturally exposed to high predator ( Rhamdia quelen ) density and tail injury had reduced brain cell proliferation compared with individuals facing few predators and those with intact tails. However, these field studies described only correlations between predator exposure and cell proliferation. Here, we used a congener Brachyhypopomus gauderio and another electric fish Apteronotus leptorhynchus to experimentally test the hypothesis that exposure to a predator stimulus and tail injury causes alterations in brain cell proliferation. To simulate predator exposure, we either amputated the tail followed by short-term (1 day) or long-term (17-18 days) recovery or repeatedly chased intact fish with a plastic rod over a 7 day period. We measured cell proliferation (PCNA+ cell density) in the telencephalon and diencephalon, and plasma cortisol, which commonly mediates stress-induced changes in brain cell proliferation. In both species, either tail amputation or simulated predator chase decreased cell proliferation in the telencephalon in a manner resembling the effect of predators in the field. In A. leptorhynchus , cell proliferation decreased drastically in the short term after tail amputation and partially rebounded after long-term recovery. In B. gauderio , tail amputation elevated cortisol levels, but repeated chasing had no effect. In A. leptorhynchus , tail amputation elevated cortisol levels in the short term but not in the long term. Thus, predator stimuli can cause reductions in brain cell proliferation, but the role of cortisol is not clear. © 2017. Published by The Company of Biologists Ltd.

Effects of water level changes and wading bird abundance on the foraging behaviour of blacknecked storks Ephippiorhynchus asiaticus in Dudwa National Park, India.

PubMed

Maheswaran, G; Rahmani, A R

2001-09-01

The effect of water level changes and wading birds' abundance on the foraging behaviour of the blacknecked stork (BNS) Ephippiorhynchus asiaticus was studied from January 1995 to June 1997 in Dudwa National Park, Uttar Pradesh. Our observations indicate that BNS territoriality increased as food levels became depleted, resulting in increased rates of aggression towards intruders. Chasing or aggression was more intense during the early period (February and March) than the late period (April, May and June). Most of (> 50%) the aggressive encounters were observed between 0600 and 1000 h of the day. Seventeen species (including BNS) were observed interacting with BNS, throughout the study period. Most interactions were with the spoonbill, Platalea leucorodia (67.4%), followed by the whitenecked stork, Ciconia episcopus (16.6%). The distance (while foraging) between BNS and other wading birds varied significantly (P < 0.001) between years indicating that BNS and other water birds foraged at different water depths and thereby explored the wetlands fully. Spoonbills were chased often; the number varied from 1 to 43 birds. BNS occasionally accepted the presence of other wading birds, including spoonbills and started foraging amidst them. This led to successful foraging of BNS (solitary feeder). Other fish-eating bird species and their numbers also limited the food consumption of foraging BNS as they had to spend time chasing away the intruders. Availability of the preferred prey fish species, Heteropnestus fossilis, forced BNS to stay throughout the year in their respective territories. High (> 60 cm) water levels were not suitable for BNS even though the patch had high prey abundance.

Orbiter "Enterprise" rides "piggy-back" atop NASA 747 carrier

NASA Image and Video Library

1977-09-23

S77-28649 (23 Sept 1977) --- The shuttle Orbiter 101 "Enterprise" sits atop the NASA 747 carrier aircraft in a piggy-back configuration prior to separation for the third free flight of the Shuttle Approach and Landing Tests (ALT) conducted on September 23, 1977, at the Dryden Flight Research Center (DFRC) in Southern California. The crew of the "enterprise" consisted of astronauts Fred W. Haise Jr., commander, and C. Gordon Fullerton, pilot. This photo was shot from one of the T-38 chase planes accompanying the ALT craft. Three other T-38 chase planes are pictured.

Nightmare Themes: An Online Study of Most Recent Nightmares and Childhood Nightmares.

PubMed

Schredl, Michael; Göritz, Anja S

2018-03-15

Even though the common diagnostic criteria (ICSD-3, DSM-5) acknowledge that nightmares do not only contain anxiety/fear (definition of the ICD-10) but also other emotions such as grief, disgust, and anger, the definition of a nightmare still focuses on threats to survival, security, or physical integrity. However, empirical studies on nightmare content in larger samples are scarce. The current study elicited 1,216 of the most recent nightmares including childhood nightmares of a population-based sample. The findings show that nightmares encompass a diversity of different topics, being chased, physical aggression, including death/injury of close persons. Infrequent themes like being the aggressor and suicide are of special interest as they might be related to waking-life psychopathology. The variety of nightmare topics clearly indicate that current definitions of nightmare content are too narrow. Future studies should look into nightmare content of persons in whom nightmare disorder has been diagnosed. © 2018 American Academy of Sleep Medicine.

Energetics and evasion dynamics of large predators and prey: pumas vs. hounds.

PubMed

Bryce, Caleb M; Wilmers, Christopher C; Williams, Terrie M

2017-01-01

Quantification of fine-scale movement, performance, and energetics of hunting by large carnivores is critical for understanding the physiological underpinnings of trophic interactions. This is particularly challenging for wide-ranging terrestrial canid and felid predators, which can each affect ecosystem structure through distinct hunting modes. To compare free-ranging pursuit and escape performance from group-hunting and solitary predators in unprecedented detail, we calibrated and deployed accelerometer-GPS collars during predator-prey chase sequences using packs of hound dogs ( Canis lupus familiaris , 26 kg, n  = 4-5 per chase) pursuing simultaneously instrumented solitary pumas ( Puma concolor , 60 kg, n  = 2). We then reconstructed chase paths, speed and turning angle profiles, and energy demands for hounds and pumas to examine performance and physiological constraints associated with cursorial and cryptic hunting modes, respectively. Interaction dynamics revealed how pumas successfully utilized terrain (e.g., fleeing up steep, wooded hillsides) as well as evasive maneuvers (e.g., jumping into trees, running in figure-8 patterns) to increase their escape distance from the overall faster hounds (avg. 2.3× faster). These adaptive strategies were essential to evasion in light of the mean 1.6× higher mass-specific energetic costs of the chase for pumas compared to hounds (mean: 0.76 vs. 1.29 kJ kg -1  min -1 , respectively). On an instantaneous basis, escapes were more costly for pumas, requiring exercise at ≥90% of predicted [Formula: see text] and consuming as much energy per minute as approximately 5 min of active hunting. Our results demonstrate the marked investment of energy for evasion by a large, solitary carnivore and the advantage of dynamic maneuvers to postpone being overtaken by group-hunting canids.

Imaging the fate of histone Cse4 reveals de novo replacement in S phase and subsequent stable residence at centromeres

PubMed Central

Wisniewski, Jan; Hajj, Bassam; Chen, Jiji; Mizuguchi, Gaku; Xiao, Hua; Wei, Debbie; Dahan, Maxime; Wu, Carl

2014-01-01

The budding yeast centromere contains Cse4, a specialized histone H3 variant. Fluorescence pulse-chase analysis of an internally tagged Cse4 reveals that it is replaced with newly synthesized molecules in S phase, remaining stably associated with centromeres thereafter. In contrast, C-terminally-tagged Cse4 is functionally impaired, showing slow cell growth, cell lethality at elevated temperatures, and extra-centromeric nuclear accumulation. Recent studies using such strains gave conflicting findings regarding the centromeric abundance and cell cycle dynamics of Cse4. Our findings indicate that internally tagged Cse4 is a better reporter of the biology of this histone variant. Furthermore, the size of centromeric Cse4 clusters was precisely mapped with a new 3D-PALM method, revealing substantial compaction during anaphase. Cse4-specific chaperone Scm3 displays steady-state, stoichiometric co-localization with Cse4 at centromeres throughout the cell cycle, while undergoing exchange with a nuclear pool. These findings suggest that a stable Cse4 nucleosome is maintained by dynamic chaperone-in-residence Scm3. DOI: http://dx.doi.org/10.7554/eLife.02203.001 PMID:24844245

B-747 in Flight during Vortex Study

NASA Technical Reports Server (NTRS)

1974-01-01

Two chase aircraft, a Learjet and a Cessna T-37, are shown in formation with a Boeing B-747 jetliner in this 1974 NASA Flight Research Center (FRC) photograph. The two chase aircraft were used to probe the trailing wake vortices generated by the airflow around the wings of the B-747 aircraft. The vortex trails were made visible by smoke generators mounted under the wings of the B-747 aircraft. In 1974 the NASA Flight Research Center (later Dryden Flight Research Center, Edwards, California) used a Boeing 747 as part of the overall NASA study of trailing vortices. Trailing vortices are the invisible flow of spiraling air that trails from the wings of large aircraft and can 'upset' smaller aircraft flying behind them. The 747 that NASA used was on loan from the Johnson Space Center where it was part of the Space Shuttle Program. The data gathered in the 747 studies complemented data from the previous (1973-74) joint NASA Flight Research Center and Federal Aviation Administration (FAA) Boeing727 wake vortices study. Six smoke generators were installed under the wings of the 747 to provide a visual image of the trailing vortices. The object of the experiments was to test different configurations and mechanical devices on the747 that could be used to break up or lessen the strength of the vortices. The results of the tests could lead to shorter spacing between landings and takeoffs, which, in turn, could alleviate air-traffic congestion. For approximately 30 flights the 747 was flown using various combinations of wing air spoilers in an attempt to reduce wake vortices. To evaluate the effectiveness of the different configurations, chase aircraft were flown into the vortex sheets to probe their strengths and patterns at different times. Two of the chase planes used were the Flight Research Center's Cessna T-37 and the NASA Ames Research Center's Learjet. These aircraft represented the types of smaller business jets and other small aircraft that might encounter large passenger aircraft on approach or landings around major airports or in flight. Tests without the 747's wing spoilers deployed produced violent 'upset' problems for the T-37 aircraft at a distance of approximately 3 miles. From the magnitude of the problems found, distances of as much as ten miles might be required if spoilers were not used. With two spoilers on the outer wing panels, the T-37 could fly at a distance of three miles and not experience the 'upset' problem. The wake vortex study continued even after the 747 was returned to its primary mission of carrying the Space Shuttle.

B-747 in Flight during Vortex Study with Learjet and T-37 Fly Through the Wake

NASA Technical Reports Server (NTRS)

1974-01-01

In this 1974 NASA Flight Research Center (FRC) photograph, the two chase aircraft, a Learjet and a Cessna T-37, are shown in formation off the right wing tip of the Boeing B-747 jetliner. The two chase aircraft were used to probe the trailing wake vortices generated by the airflow around the wings of the B-747 aircraft. The vortex trail behind the right wing tip was made visible by a smoke generator mounted under the wing of the B-747 aircraft. In 1974 the NASA Flight Research Center (later Dryden Flight Research Center, Edwards, California) used a Boeing 747 as part of the overall NASA study of trailing vortices. Trailing vortices are the invisible flow of spiraling air that trails from the wings of large aircraft and can 'upset' smaller aircraft flying behind them. The 747 that NASA used was on loan from the Johnson Space Center where it was part of the Space Shuttle Program. The data gathered in the 747 studies complemented data from the previous (1973-74) joint NASA Flight Research Center and Federal Aviation Administration (FAA) Boeing727 wake vortices study. Six smoke generators were installed under the wings of the 747 to provide a visual image of the trailing vortices. The object of the experiments was to test different configurations and mechanical devices on the747 that could be used to break up or lessen the strength of the vortices. The results of the tests could lead to shorter spacing between landings and takeoffs, which, in turn, could alleviate air-traffic congestion. For approximately 30 flights the 747 was flown using various combinations of wing air spoilers in an attempt to reduce wake vortices. To evaluate the effectiveness of the different configurations, chase aircraft were flown into the vortex sheets to probe their strengths and patterns at different times. Two of the chase planes used were the Flight Research Center's Cessna T-37 and the NASA Ames Research Center's Learjet. These aircraft represented the types of smaller business jets and other small aircraft that might encounter large passenger aircraft on approach or landings around major airports or in flight. Tests without the 747's wing spoilers deployed produced violent 'upset' problems for the T-37 aircraft at a distance of approximately 3 miles. From the magnitude of the problems found, distances of as much as ten miles might be required if spoilers were not used. With two spoilers on the outer wing panels, the T-37 could fly at a distance of three miles and not experience the 'upset' problem. The wake vortex study continued even after the 747 was returned to its primary mission of carrying the Space Shuttle.

Chasing Legitimacy: The US National Music Standards Viewed through a Critical Theorist Framework

ERIC Educational Resources Information Center

Benedict, Cathy

2006-01-01

This study examines the US National Music Standards from two perspectives. The study situates the status of music education as a marginalized society and postulates that the standards are a by product of larger forces and powerful assumptions. In order to better understand how these forces might have influenced the development and adoption of the…

[Characteristics of autonomic status in employees working with computers].

PubMed

Vlasova, E M; Zaĭtseva, N V; Maliutina, N N

2011-01-01

Human evolution is accompanied by "sensible thoughts" spread to all spheres of occupational activities. One can hardly find an industrial enterprise without computers. In contemporary industry, health care in conditions of humans and computers interaction and evaluation of harm in computer users remain topical. Social and occupational environment is not always comfortable for human body. Changes is occupational conditions, with wide use of computer technologies, decrease role of manual labour and increase role of intellectual work from the one hand, but from the other hand, chasing economic profit alters individual "comfort zone" due to constant psychoemotional stress and causes "burnout". Being healthy in constant stress is impossible.

Behavioural profiles in the mouse defence test battery suggest anxiolytic potential of 5-HT(1A) receptor antagonists.

PubMed

Griebel, G; Rodgers, R J; Perrault, G; Sanger, D J

1999-05-01

Compounds varying in selectivity as 5-HT1A receptor antagonists have recently been reported to produce anxiolytic-like effects comparable to those of benzodiazepines in the mouse elevated plus-maze procedure. In view of the potential clinical significance of these findings, the present experiments compared the behavioural effects of diazepam (0.5-3.0 mg/kg) with those of several non-selective 5-HT1A receptor antagonists [NAN-190, 0.1-3.0 mg/kg, MM-77, 0.03-1.0 mg/kg, (S)-UH-301, 0.3-3.0 mg/kg and pindobind-5-HT1A, 0.03-1.0 mg/kg], and three selective 5-HT1A receptor antagonists (WAY100635, 0.01-3.0 mg/kg, p-MPPI, 0.1-3.0 mg/kg and SL88.0338, 0.3-3.0 mg/kg) in the mouse defence test battery (MDTB). In this well-validated anxiolytic screening test, Swiss mice are directly confronted with a natural threat (a rat) as well as situations associated with this threat. Primary measures taken during and after rat confrontation were flight, risk assessment (RA), defensive threat/attack and escape attempts. Diazepam significantly decreased flight reactions after the rat was introduced into the runway, reduced RA activities of mice chased by the rat, increased RA responses displayed when subjects were constrained in a straight alley and reduced defensive upright postures and biting upon forced contact. All the selective 5-HT1A receptor antagonists and NAN-190 also reduced flight, RA in the chase test, and defensive threat and attack behaviours. (S)-UH-301 and pindobind-5-HT1A reduced RA in the chase test, but only partially modified defensive threat and attack. Unlike the other drugs tested, MM-77 produced significant effects only at doses which also markedly reduced spontaneous locomotor activity, suggesting a behaviourally non-specific action. In contrast to diazepam, the 5-HT1A receptor ligands failed to affect RA in the straight alley test. Following removal of the rat from the test area, only diazepam and (S)-UH-301 reduced escape behaviour (contextual defence) at doses which did not decrease locomotion. Overall, the present findings indicate that except for one RA behaviour and escape responses, the 5-HT1A receptor ligands studied modified the same defensive behaviours as diazepam, suggesting potential therapeutic efficacy in the management of anxiety disorders. However, the magnitude of the effects of the 5-HT1A compounds on defence was generally smaller than that of the benzodiazepine. As all of the 5-HT1A compounds tested in this series share antagonistic activity in models of postsynaptic 5-HT1A receptor function, it is proposed that this action accounts for their effects on defence.

Chasing "Ubuntu": Using ICTs to Promote Reflective Practice

ERIC Educational Resources Information Center

Malone, Todd; Wilder, Hilary

2008-01-01

Purpose: To describe an exploratory study in which an online learning system was used to provide an intercultural experience for pre-service education students from New Jersey and Namibia. Design/methodology/approach: Pre-service education students from New Jersey and Namibia were enrolled in an online course in the fall of 2004. The following…

Chasing Innovation: A Pilot Case Study of a Rhizomatic Design Thinking Education Program

ERIC Educational Resources Information Center

Biffi, Alfredo; Bissola, Rita; Imperatori, Barbara

2017-01-01

Purpose: The purpose of this paper is to illustrate and discuss the main features and key challenges of an original post-graduate education program designed according to an innovative theoretical framework promoting design thinking in a rhizomatic approach. By involving different stakeholders, the aim of this entrepreneurship education program is…

Processing of human cytomegalovirus glycoprotein B in recombinant adenovirus-infected cells.

PubMed

Marshall, G S; Fenger, D P; Stout, G G; Knights, M E; Hunt, L A

1996-07-01

Intracellular processing of human cytomegalovirus (HCMV) glycoprotein B (gB; gpUL55) expressed by a recombinant adenovirus (Ad-gB) was studied in human A549 cells as processing events could affect immunogenicity when such viruses are used as live-recombinant vaccines. Cleavage of [35S]methionine-labelled gp13O into gp93 and gp55 reached a maximum after a 3 h chase. Cleavage was completely inhibited by brefeldin A, suggesting that processing normally occurs as a late Golgi or post-Golgi event. Uncleaved gp 130 remained completely sensitive to endo-beta-N-acetylglucosaminidase H (Endo-H) in untreated cells following long chase periods, indicating high-mannose oligosaccharides at all of the 18 N-linked glycosylation sites (Asn-X-Ser/Thr) and retention in the endoplasmic reticulum. Endo-H analysis of gp55 from swainsonine-treated and untreated cells was consistent with glycosylation at all three potential sites, with two oligosaccharides remaining sensitive to Endo-H and one being processed to Endo-H resistance. The heavily glycosylated N-terminal gp93 subunit was not detected by [35S]methionine-labelling but was easily detected along with gp55 after labelling with [3H]mannose. No cleavage of gp 130 was observed in analogous pulse-chase radiolabelling of Ad-gB-infected human fibroblasts, even though these cells are permissive for HCMV replication and can process the native gB molecule. Processing of gB in recombinant adenovirus-infected A549 cells was generally similar to that previously reported for native gB in HCMV-infected fibroblasts.

Visual field shape and foraging ecology in diurnal raptors.

PubMed

Potier, Simon; Duriez, Olivier; Cunningham, Gregory B; Bonhomme, Vincent; O'Rourke, Colleen; Fernández-Juricic, Esteban; Bonadonna, Francesco

2018-05-18

Birds, particularly raptors, are believed to forage primarily using visual cues. However, raptor foraging tactics are highly diverse - from chasing mobile prey to scavenging - which may reflect adaptations of their visual systems. To investigate this, we studied the visual field configuration of 15 species of diurnal Accipitriformes that differ in such tactics, first focusing on the binocular field and blind area by using a single traits approach, and then exploring the shape of the binocular field with morphometric approaches. While the maximum binocular field width did not differ in species of different foraging tactics, the overall shape of their binocular fields did. In particular, raptors chasing terrestrial prey (ground predators) had a more protruding binocular field and a wider blind area above the head than did raptors chasing aerial or aquatic prey and obligate scavengers. Ground predators that forage on mammals from above have a wide but short bill - which increases ingestion rate - and large suborbital ridge to avoid sun glare. This may explain the protruding binocular field and the wide blind area above the head. By contrast, species from the two other groups have long but narrow bills used to pluck, flake or tear food and may need large visual coverage (and reduced suborbital ridges) to increase their foraging efficiency ( e.g. using large visual coverage to follow the escaping prey in three dimensions or detect conspecifics). We propose that binocular field shape is associated with bill and suborbital ridge shape and, ultimately, foraging strategies. © 2018. Published by The Company of Biologists Ltd.

Bacillus megaterium sporal peptidoglycan synthesis studied by high-resolution autoradiography.

PubMed

Frehel, C; Ryter, A

1980-11-01

Cells of a Dap- Lys- mutant strain of Bacillus megaterium were pulse labeled with [3H]diaminopimelic acid at different times of growth and sporulation. They were processed for radioactivity measurements and high-resolution autoradiography either just after the pulse or after a chase in a nonradioactive medium until refractile forespores started to appear at time (t)4,5. In the pulse-labeled cells, autoradiographs and radioactivity measurements showed that the radioactivity incorporated during a pulse decreased abruptly after t0 and stayed at a low level until t5, although the forespore wall and cortex were formed between t4 and t5. In the pulse-chased bacteria, the acid-insoluble radioactivity, as well as the number of silver grains on autoradiographs, increased during the chase in cells labeled at t1 to t2, whereas it decreased in those labeled before t0. Furthermore, analysis of silver grain distribution showed that, in stage IV bacteria, grains were distributed at the outside of the forespore, mostly on the sporangium cell wall, when pulse-labeling occurred before or at t0; they were located along the cortex and in the forespore cytoplasm when labeling was made at t1 or t2. These facts show that [3H]diaminopimelic acid necessary for spore envelope synthesis was incorporated before their morphological appearance. Free or small diaminopimelic acid precursors entered the sporangium between t1 and t2. The appearance of silver grains in the forespore cytoplasm suggests that the forespore is implicated in sporal peptidoglycan synthesis.

Wars of the holographic world

NASA Astrophysics Data System (ADS)

Preskill, John

2008-12-01

In the popular imagination, the iconic American theoretical physicist is Richard Feynman, in all his safe-cracking, bongo-thumping, woman-chasing glory. I suspect that many physicists, if asked to name a living colleague who best captures the spirit of Feynman, would give the same answer as me: Leonard Susskind. As far as I know, Susskind does not crack safes, thump bongos, or chase women, yet he shares Feynman's brash cockiness (which in Susskind's case is leavened by occasional redeeming flashes of self-deprecation) and Feynman's gift for spinning fascinating anecdotes. If you are having a group of physicists over for dinner and want to be sure to have a good time, invite Susskind.

Pilot Ed Lewis with T-34C aircraft on ramp

NASA Image and Video Library

1998-03-04

NASA pilot Ed Lewis with the T-34C aircraft on the Dryden Flight Research Center Ramp. The aircraft was previously used at the Lewis Research Center in propulsion experiments involving turboprop engines, and was used as a chase aircraft at Dryden for smaller and slower research projects. Chase aircraft accompany research flights for photography and video purposes, and also as support for safety and research. At Dryden, the T-34 is used mainly for smaller remotely piloted vehicles which fly slower than NASA's F-18's, used for larger scale projects. This aircraft was returned to the U.S. Navy in May of 2002.

Inhibition of processing of plant N-linked oligosaccharides by castanospermine.

PubMed

Hori, H; Pan, Y T; Molyneux, R J; Elbein, A D

1984-02-01

Castanospermine (1,6,7,8-tetrahydroxyoctahydroindolizine) is a plant alkaloid that inhibits lysosomal alpha- and beta-glucosidase. It also inhibits processing of influenza viral glycoproteins by inhibiting glucosidase I and leads to altered glycoproteins with Glc3Man7GlcNAc2 structures. Castanospermine was tested as an inhibitor of glycoprotein processing in suspension-cultured soybean cells. Soybean cells were pulse-labeled with [2-3H]mannose and chased for varying periods in unlabeled medium. In normal cells, the initial glycopeptides contained oligosaccharides having Glc3Man9GlcNAc2 to Glc1Man9GlcNAc2 structures and these were trimmed during the chase to Man9GlcNac2 to Man7GlcNAc2 structures. In the presence of castanospermine, no trimming of glucose residues occurred although some mannose residues were apparently still removed. Thus, the major oligosaccharide in the glycopeptides of castanospermine-incubated cells after a 90-min chase was a Glc3Man7GlcNAc2 structure. Smaller amounts of Glc3Man6GlcNAc2 and Glc3Man5GlcNAc2 were also identified. Thus, in plant cells, castanospermine also prevents the removal of the outermost glucose residue.

Dynamic properties of chasers in a moving queue based on a delayed chasing model

NASA Astrophysics Data System (ADS)

Ning, Guo; Jian-Xun, Ding; Xiang, Ling; Qin, Shi; Reinhart, Kühne

2016-05-01

A delayed chasing model is proposed to simulate the chase behavior in the queue, where each member regards the closest one ahead as the target, and the leader is attracted to a target point with slight fluctuation. When the initial distances between neighbors possess an identical low value, the fluctuating target of the leader can cause an amplified disturbance in the queue. After a long period of time, the queue recovers the stable state from the disturbance, forming a straight-line-like pattern again, but distances between neighbors grow. Whether the queue can keep stable or not depends on initial distance, desired velocity, and relaxation time. Furthermore, we carry out convergence analysis to explain the divergence transformation behavior and confirm the convergence conditions, which is in approximate agreement with simulations. Project supported by the National Natural Science Foundation of China (Grant Nos. 71071044, 71001001, 71201041, and 11247291), the Doctoral Program of the Ministry of Education of China (Grant Nos. 20110111120023 and 20120111120022), the Postdoctoral Fund Project of China (Grant No. 2013M530295), the National Basic Research Program of China (Grant No. 2012CB725404), and 1000 Plan for Foreign Talent, China (Grant No. WQ20123400070).

Steering a virtual blowfly: simulation of visual pursuit.

PubMed

Boeddeker, Norbert; Egelhaaf, Martin

2003-09-22

The behavioural repertoire of male flies includes visually guided chasing after moving targets. The visuomotor control system for these pursuits belongs to the fastest found in the animal kingdom. We simulated a virtual fly, to test whether or not experimentally established hypotheses on the underlying control system are sufficient to explain chasing behaviour. Two operating instructions for steering the chasing virtual fly were derived from behavioural experiments: (i) the retinal size of the target controls the fly's forward speed and, thus, indirectly its distance to the target; and (ii) a smooth pursuit system uses the retinal position of the target to regulate the fly's flight direction. Low-pass filters implement neuronal processing time. Treating the virtual fly as a point mass, its kinematics are modelled in consideration of the effects of translatory inertia and air friction. Despite its simplicity, the model shows behaviour similar to that of real flies. Depending on its starting position and orientation as well as on target size and speed, the virtual fly either catches the target or follows it indefinitely without capture. These two behavioural modes of the virtual fly emerge from the control system for flight steering without implementation of an explicit decision maker.

Design of the LBNF Beamline Target Station

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tariq, S.; Ammigan, K.; Anderson, K.

2016-10-01

The Long Baseline Neutrino Facility (LBNF) project will build a beamline located at Fermilab to create and aim an intense neutrino beam of appropriate energy range toward the DUNE detectors at the SURF facility in Lead, South Dakota. Neutrino production starts in the Target Station, which consists of a solid target, magnetic focusing horns, and the associated sub-systems and shielding infrastructure. Protons hit the target producing mesons which are then focused by the horns into a helium-filled decay pipe where they decay into muons and neutrinos. The target and horns are encased in actively cooled steel and concrete shielding inmore » a chamber called the target chase. The reference design chase is filled with air, but nitrogen and helium are being evaluated as alternatives. A replaceable beam window separates the decay pipe from the target chase. The facility is designed for initial operation at 1.2 MW, with the ability to upgrade to 2.4 MW, and is taking advantage of the experience gained by operating Fermilab’s NuMI facility. We discuss here the design status, associated challenges, and ongoing R&D and physics-driven component optimization of the Target Station.« less

Evaluation of diesel fleet emissions and control policies from plume chasing measurements of on-road vehicles

NASA Astrophysics Data System (ADS)

Lau, Chui Fong; Rakowska, Agata; Townsend, Thomas; Brimblecombe, Peter; Chan, Tat Leung; Yam, Yat Shing; Močnik, Griša; Ning, Zhi

2015-12-01

Vehicle emissions are an important source of urban air pollution. Diesel fuelled vehicles, although constituting a relatively small fraction of fleet population in many cities, are significant contributors to the emission inventory due to their often long mileage for goods and public transport. Recent classification of diesel exhaust as carcinogenic by the World Health Organization also raises attention to more stringent control of diesel emissions to protect public health. Although various mandatory and voluntary based emission control measures have been implemented in Hong Kong, there have been few investigations to evaluate if the fleet emission characteristics have met desired emission reduction objectives and if adoption of an Inspection/Maintenance (I/M) programme has been effective in achieving these objectives. The limitations are partially due to the lack of cost-effective approaches for the large scale characterisation of fleet based emissions to assess the effectiveness of control measures and policy. This study has used a plume chasing method to collect a large amount of on-road vehicle emission data of Hong Kong highways and a detailed analysis was carried out to provide a quantitative evaluation of the emission characteristics in terms of the role of high and super-emitters in total emission reduction, impact of after-treatment on the multi-pollutants reduction strategy and the trend of NO2 emissions with newer emission standards. The study revealed that not all the high-emitters are from those vehicles of older Euro emission standards. Meanwhile, there is clear evidence that high-emitters for one pollutant may not be a high-emitter for another pollutant. Multi-pollutant control strategy needs to be considered in the enactment of the emission control policy which requires more comprehensive retrofitting technological solutions and matching I/M programme to ensure the proper maintenance of fleets. The plume chasing approach used in this study also shows to be a useful approach for assessing city wide vehicle emission characteristics.

Lockheed L-1011 TriStar to support Adaptive Performance Optimization study with NASA F-18 chase plan

NASA Technical Reports Server (NTRS)

1995-01-01

This Lockheed L-1011 Tristar, seen here June 1995, is currently the subject of a new flight research experiment developed by NASA's Dryden Flight Research Center, Edwards, California, to improve the effiecency of large transport aircraft. Shown with a NASA F-18 chase plane over California's Sierra Nevada mountains during an earlier baseline flight, the jetliner operated by Oribtal Sciences Corp., recently flew its first data-gathering mission in the Adaptive Performance Optimization project. The experiment seeks to reduce fuel comsumption of large jetliners by improving the aerodynamic efficiency of their wings at cruise conditions. A research computer employing a sophisticated software program adapts to changing flight conditions by commanding small movements of the L-1011's outboard ailerons to give its wings the most efficient - or optimal - airfoil. Up to a dozen research flights will be flown in the current and follow-on phases of the project over the next couple years.

Doubly illegal: Qualitative accounts of underage alcohol access through theft

PubMed Central

Jennings, Vanessa K.; Friese, Bettina; Moore, Roland S.; Grube, Joel W.

2012-01-01

This study investigated sources of alcohol for underage drinkers. In-depth, semi-structured interviews were individually conducted with 47 youths, ages 15–18, who reported drinking within the last 12 months, to explore alcohol access. Theft was one method that some youths reported using to obtain alcohol. In addition to 9% of respondents who reported stealing alcohol from commercial outlets themselves, a total of 26% respondents reported occasions when their close friends stole alcohol. Our findings unveiled that teens had a body of knowledge that some drew upon for stealing alcohol. Youths revealed detailed knowledge about store layout, theft protection devices and store policies. In particular, respondents disclosed knowledge about which aisles have blind spots, how to remove security tops on bottles, and no-chase policies. Theft of alcohol from commercial sources may be reduced by examining the weaknesses of existing theft prevention practices, and revising store policies. PMID:22303285

Daily Fantasy Football and Self-Reported Problem Behavior in the United States.

PubMed

Dwyer, Brendan; Shapiro, Stephen L; Drayer, Joris

2017-09-26

Traditional, season-long fantasy sport participation has grown considerably since the late 1990s, and in an attempt to capitalize on this growing demand, daily fantasy sports (DFS) providers have created a new game where money changes hands instantly. This change has led some legal commentators and state agencies to believe the game is a form of Internet gambling similar to online poker, blackjack, and sports wagering, and thus, it requires increased regulation or even prohibition. Little is known, however, about the gambling behavior associated with DFS participation. Thus, the purpose of the current study was to examine problem gambling severity in conjunction with DFS participant motives, perceptions, and consumption behavior. Over 500 DFS participants were surveyed, and the results suggest DFS participants behave similarly with participants in other forms of gambling activities. In addition, the findings suggest additional consumer protections may be needed to prevent further problem behavior such as chasing.

Individual, team, and coach predictors of players' likelihood to aggress in youth soccer.

PubMed

Chow, Graig M; Murray, Kristen E; Feltz, Deborah L

2009-08-01

The purpose of this study was to examine personal and socioenvironmental factors of players' likelihood to aggress. Participants were youth soccer players (N = 258) and their coaches (N = 23) from high school and club teams. Players completed the Judgments About Moral Behavior in Youth Sports Questionnaire (JAMBYSQ; Stephens, Bredemeier, & Shields, 1997), which assessed athletes' stage of moral development, team norm for aggression, and self-described likelihood to aggress against an opponent. Coaches were administered the Coaching Efficacy Scale (CES; Feltz, Chase, Moritz, & Sullivan, 1999). Using multilevel modeling, results demonstrated that the team norm for aggression at the athlete and team level were significant predictors of athletes' self likelihood to aggress scores. Further, coaches' game strategy efficacy emerged as a positive predictor of their players' self-described likelihood to aggress. The findings contribute to previous research examining the socioenvironmental predictors of athletic aggression in youth sport by demonstrating the importance of coaching efficacy beliefs.

The Positive Aspects of Aggressive Behavior in Young Children.

ERIC Educational Resources Information Center

Periolat, Janet; Nager, Nancy

Not all fighting or aggression in young children is bad, and some kinds of teacher intervention may be beneficial. Play-fighting refers primarily to rough and tumble play and chasing, and several studies have shown that play and serious fighting can be clearly distinguished in young children. Numerous authors have pointed out the value and…

Asterion and Chara--The Confusion of the Chase

ERIC Educational Resources Information Center

Bernholz, Charles D.; Lyons, Michael J.

2002-01-01

The study of astronomy, as an important part of any science education programme, provides our students with insights into more than just the cosmos. It may also serve as a mechanism to link them to other natural and social sciences. This article examines equally valid interpretations of the constellation Canes Venatici as an example of how the…

Chasing a Moving Target: Perceptions of Work Readiness and Graduate Capabilities in Music Higher Research Degree Students

ERIC Educational Resources Information Center

Harrison, Scott; Grant, Catherine

2016-01-01

Recent efforts to increase workplace readiness in university students have largely centred on undergraduates, with comparatively few strategies or studies focusing on higher research degree candidates. In the discipline of music, a wide diversity of possible career paths combined with rapidly changing career opportunities makes workplace readiness…

75 FR 23847 - Joint Biomedical Laboratory Research and Development and Clinical Science Research and...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-04

... dates indicated below: Panel Date(s) Location Cardiovascular Studies May 24, 2010 St. Gregory Hotel & Suites. Immunology-A May 25, 2010 L'Enfant Plaza Hotel. Mental Hlth & Behav Sci-B May 26, 2010 Embassy... Chase. Nephrology June 4, 2010 Hotel Palomar. Infectious Diseases-B June 4, 2010 L'Enfant Plaza Hotel...

Where the Brain Appreciates the Final State of an Event: The Neural Correlates of Telicity

ERIC Educational Resources Information Center

Romagno, Domenica; Rota, Giuseppina; Ricciardi, Emiliano; Pietrini, Pietro

2012-01-01

In this study we investigated whether the human brain distinguishes between telic events that necessarily entail a specified endpoint (e.g., "reaching"), and atelic events with no delimitation or final state (e.g., "chasing"). We used functional magnetic resonance imaging to explore the patterns of neural response associated with verbs denoting…

76 FR 58025 - Center for Scientific Review Amended Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-19

... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review Amended Notice of Meeting Notice is hereby given of a change in the meeting of the Tumor Cell Biology Study Section, October 10, 2011, 8 a.m. to October 11, 2011, 5 p.m., Embassy Suites at the Chevy Chase...

Structures of the Oligosaccharides of the Glycoprotein Coded by Early Region E3 of Adenovirus 2

PubMed Central

Kornfeld, Rosalind; Wold, William S. M.

1981-01-01

Early region E3 of adenovirus 2 encodes a glycoprotein, E3-gp25K, that is a good model with which to study structure-function relationships in transmembrane glycoproteins. We have determined the structures of the oligosaccharides linked to E3-gp25K. The oligosaccharides were labeled with [2-3H]mannose in adenovirus 2-early infected KB cells for 5.5h (pulse) or for 5.5 h followed by a 3-h chase (pulse-chase). E3-gp25K was extracted and purified by chromatography on DEAE-Sephacel in 7 M urea, followed by gel filtration on a column of Bio-Gel A-1.5m in 6 M guanidine hydrochloride. An analysis of the purified protein by sodium dodecyl sulfate-polyacrylamide gel electrophoresis indicated that it was >95% pure. The oligosaccharides were isolated by pronase digestion followed by gel filtration on a column of Bio-Gel P-6, then by digestion with endo-β-N-acetylglucosaminidase H, followed by gel filtration on Bio-Gel P-6, and finally by paper chromatography. The pulse sample contained equal amounts of Man9GlcNAc and Man8GlcNAc and small amounts of Man7GlcNAc and Man6GlcNAc. The pulse-chase sample had predominantly Man8GlcNAc and much less Man9GlcNAc, indicating that processing of the Man9GlcNAc to Man8GlcNAc had occurred during the chase period. Thus, Man8GlcNAc is the major oligosaccharide on mature E3-gp25K. The structures of these oligosaccharides were established by digestion with α-mannosidase, methylation analysis, and acetolysis. The oligosaccharides found had typical high-mannose structures that have been observed in other membrane and soluble glycoproteins, and the branching patterns and linkages of the mannose residues of Man9GlcNAc were identical to those of the lipid-linked Glc3Man9GlcNAc2 donor. Thus, adenovirus 2 infection (early stages) apparently does not affect the usual cellular high-mannose glycosylation pathways, and despite being virus coded, E3-gp25K is glycosylated in the same manner as a typical mammalian cell-coded glycoprotein. Images PMID:7321093

Structures of the oligosaccharides of the glycoprotein coded by early region E3 of adenovirus 2.

PubMed

Kornfeld, R; Wold, W S

1981-11-01

Early region E3 of adenovirus 2 encodes a glycoprotein, E3-gp25K, that is a good model with which to study structure-function relationships in transmembrane glycoproteins. We have determined the structures of the oligosaccharides linked to E3-gp25K. The oligosaccharides were labeled with [2-(3)H]mannose in adenovirus 2-early infected KB cells for 5.5h (pulse) or for 5.5 h followed by a 3-h chase (pulse-chase). E3-gp25K was extracted and purified by chromatography on DEAE-Sephacel in 7 M urea, followed by gel filtration on a column of Bio-Gel A-1.5m in 6 M guanidine hydrochloride. An analysis of the purified protein by sodium dodecyl sulfate-polyacrylamide gel electrophoresis indicated that it was >95% pure. The oligosaccharides were isolated by pronase digestion followed by gel filtration on a column of Bio-Gel P-6, then by digestion with endo-beta-N-acetylglucosaminidase H, followed by gel filtration on Bio-Gel P-6, and finally by paper chromatography. The pulse sample contained equal amounts of Man(9)GlcNAc and Man(8)GlcNAc and small amounts of Man(7)GlcNAc and Man(6)GlcNAc. The pulse-chase sample had predominantly Man(8)GlcNAc and much less Man(9)GlcNAc, indicating that processing of the Man(9)GlcNAc to Man(8)GlcNAc had occurred during the chase period. Thus, Man(8)GlcNAc is the major oligosaccharide on mature E3-gp25K. The structures of these oligosaccharides were established by digestion with alpha-mannosidase, methylation analysis, and acetolysis. The oligosaccharides found had typical high-mannose structures that have been observed in other membrane and soluble glycoproteins, and the branching patterns and linkages of the mannose residues of Man(9)GlcNAc were identical to those of the lipid-linked Glc(3)Man(9)GlcNAc(2) donor. Thus, adenovirus 2 infection (early stages) apparently does not affect the usual cellular high-mannose glycosylation pathways, and despite being virus coded, E3-gp25K is glycosylated in the same manner as a typical mammalian cell-coded glycoprotein.

The effects of brefeldin-A on the high mannose oligosaccharides of mouse thyrotropin, free alpha-subunits, and total glycoproteins.

PubMed

Perkel, V S; Liu, A Y; Miura, Y; Magner, J A

1988-07-01

We have studied the effects of Brefeldin-A (BFA) on the processing of high mannose (Man) oligosaccharides of TSH. BFA is a drug that inhibits the intracellular translocation of newly synthesized glycoproteins and causes dilatation of the rough endoplasmic reticulum (RER) as well as mild swelling of the Golgi apparatus. Mouse pituitary thyrotropic tumor tissue was incubated with [3H]Man for a 2-h pulse, with and without a 3-h chase; BFA (5 micrograms/ml) was included during selected pulse and selected chase incubations. TSH and free alpha-subunits were obtained from detergent lysates of tissue by immunoprecipitation using specific antisera. Total glycoproteins were obtained by trichloroacetic acid precipitation. Endoglycosidase-H-released [3H]oligosaccharides were analyzed by paper chromatography. BFA inhibited carbohydrate processing of TSH, free alpha-subunits, and total glycoproteins, resulting in the accumulation of Man8GlcNAc2, Man7GlcNAc2, Man6GlcNAc2, and Man5GlcNAc2, especially during the chase period. Subcellular fractions enriched in RER, heavy (proximal) Golgi, and light (distal) Golgi were prepared by centrifugation in discontinuous sucrose gradients. [3H]Man-labeled oligosaccharides of TSH and total glycoproteins in the subcellular fractions were analyzed. In contrast to oligosaccharides with eight or nine Man residues found in control incubations, BFA caused the accumulation of oligosaccharides containing five to eight Man residues. These BFA-induced oligosaccharide alterations began in the RER and proximal Golgi with the 2-h pulse and extended into the distal Golgi during the chase incubations. Thus, BFA blocks the normal intracellular transport and processing of TSH, free alpha-subunits, and total glycoproteins within thyrotrophs, causing species with smaller than normal high Man oligosaccharides to appear in subcellular compartments as early as the RER. The translocation block between RER and Golgi produced by BFA may prevent the processing of Man8GlcNAc2 to Man5GlcNAc2 by Golgi (alpha,1-2)mannosidase I, yet the species retained within the RER may be subject to ongoing processing by endoplasmic reticulum (alpha,1-2)mannosidase, resulting in the accumulation of Man5-8GlcNAc2 within the RER.

The Chase to Capture Gamma Ray Bursts

NASA Technical Reports Server (NTRS)

Gehrels, Neil

2008-01-01

Gamma-ray bursts are the most powerful explosions in the universe, thought to be the birth cries of black holes. It has taken 40 years of international cooperation and competition to begin to unravel the mystery of their origin. The most recent chapter in this field is being written by the SWIFT mission, a fast-response satellite with 3 power telescopes. An international team from countries all over the world participates in the chase to capture the fading light of bursts detected by SWIFT. This talk will discuss the challenges and excitement of building this space observatory. New results will be presented on our growing understanding of exploding stars and fiery mergers of orbiting stars.

Alpha-SNAP functions in insulin exocytosis from mature, but not immature secretory granules in pancreatic beta cells.

PubMed

Nakamichi, Y; Nagamatsu, S

1999-06-24

To explore alpha-SNAP function in insulin exocytosis from either immature or mature secretory granules in pancreatic beta cells, we studied the effects of overexpression of adenovirus-mediated wild-type alpha-SNAP and C-terminally deleted alpha-SNAP mutant (1-285) on newly synthesized proinsulin and insulin release by rat islets and MIN6 cells. Rat islets overexpressing alpha-SNAP and mutant alpha-SNAP were pulse-chased. Exocytosis from immature and mature insulin secretory granules was measured as fractional (%) labeled-proinsulin release immediately after the pulse-labeling and percentage labeled-insulin release after a 3-h chase period, respectively. There was no difference in percentage labeled-proinsulin release between the control and alpha-SNAP or mutant alpha-SNAP-overexpressed islets. Although percentage labeled-insulin release after a 3-h chase period was significantly increased in alpha-SNAP-overexpressed islets, it was decreased in mutant alpha-SNAP-overexpressed islets. Thus, the results demonstrated that alpha-SNAP overexpression in rat islets primarily increased exocytosis from mature, but not immature insulin secretory granules. On the other hand, in MIN6 cells, alpha-SNAP overexpression scarcely affected glucose-stimulated insulin release; therefore, we examined the effect of mutant alpha-SNAP overexpression as the dominant-negative inhibitor on the newly synthesized proinsulin/insulin release using the same protocol as in the rat islet experiments. alpha-SNAP mutant (1-285) overexpression in MIN6 cells decreased the percentage labeled insulin release from mature secretory granules, but not percentage labeled proinsulin release from immature secretory granules. Thus, our data demonstrate that alpha-SNAP functions mainly in the mature insulin secretory granules in pancreatic beta cells. Copyright 1999 Academic Press.

Digital data sets that describe aquifer characteristics of the Central Oklahoma Aquifer in central Oklahoma

USGS Publications Warehouse

Runkle, D.L.; Christenson, S.C.; Rea, Alan

1997-01-01

ARC/INFO export files The data sets in this report include digitized aquifer boundaries and maps of hydraulic conductivity, recharge, and ground-water level elevation contours for the Central Oklahoma aquifer in central Oklahoma. This area encompasses all or part of Cleveland, Lincoln, Logan, Oklahoma, Payne, and Pottawatomie Counties. The Central Oklahoma aquifer includes the alluvial and terrace deposits along major streams, the Garber Sandstone and Wellington Formations, and the Chase, Council Grove, and Admire Groups. The Quaternary-age alluvial and terrace deposits consist of unconsolidated clay, silt, sand, and gravel. The Permian-age Garber Sandstone and Wellington Formations consist of sandstone with interbedded siltstone and mudstone. The Permian-age Chase, Council Grove, and Admire Groups consist of sandstone, shale, and thin limestone. The Central Oklahoma aquifer underlies about 3,000 square miles of central Oklahoma where the aquifer is used extensively for municipal, industrial, commercial, and domestic water supplies. Most of the usable ground water within the aquifer is from the Garber Sandstone and Wellington Formations. Substantial quantities of usable ground water also are present in the Chase, Council Grove, and Admire Groups, and in alluvial and terrace deposits associated with the major streams. The aquifer boundaries, hydraulic conductivity and recharge values, and ground-water level elevation contours are from previously published reports.

Real-time measurements of nitrogen oxide emissions from in-use New York City transit buses using a chase vehicle.

PubMed

Shorter, Joanne H; Herndon, Scott; Zahniser, Mark S; Nelson, David D; Wormhoudt, Joda; Demerjian, Kenneth L; Kolb, Charles E

2005-10-15

New diesel engine technologies and alternative fuel engines are being introduced into fleets of mass transit buses to try to meet stricter emission regulations of nitrogen oxides and particulates: Real-time instruments including an Aerodyne Research tunable infrared laser differential absorption spectrometer (TILDAS) were deployed in a mobile laboratory to assess the impact of the implementation of the new technologies on nitrogen oxide emissions in real world driving conditions. Using a "chase" vehicle sampling strategy, the mobile laboratory followed target vehicles, repeatedly sampling their exhaust. Nitrogen oxides from approximately 170 in-use New York City mass transit buses were sampled during the field campaigns. Emissions from conventional diesel buses, diesel buses with continuously regenerating technology (CRT), diesel hybrid electric buses, and compressed natural gas (CNG) buses were compared. The chase vehicle sampling method yields real world emissions that can be included in more realistic emission inventories. The NO, emissions from the diesel and CNG buses were comparable. The hybrid electric buses had approximately one-half the NOx emissions. In CRT diesels, NO2 accounts for about one-third of the NOx emitted in the exhaust, while for non-CRT buses the NO2 fraction is less than 10%.

Mate competition and evolutionary outcomes in genetically modified zebrafish (Danio rerio).

PubMed

Howard, Richard D; Rohrer, Karl; Liu, Yiyang; Muir, William M

2015-05-01

Demonstrating relationships between sexual selection mechanisms and trait evolution is central to testing evolutionary theory. Using zebrafish, we found that wild-type males possessed a significant advantage in mate competition over transgenic RFP Glofish® males. In mating trials, wild-type males were aggressively superior to transgenic males in male-male chases and male-female chases; as a result, wild-type males sired 2.5× as many young as did transgenic males. In contrast, an earlier study demonstrated that female zebrafish preferred transgenic males as mates when mate competition was excluded experimentally. We tested the evolutionary consequence of this conflict between sexual selection mechanisms in a long-term study. The predicted loss of the transgenic phenotype was confirmed. More than 18,500 adults collected from 18 populations across 15 generations revealed that the frequency of the transgenic phenotype declined rapidly and was eliminated entirely in all but one population. Fitness component data for both sexes indicated that only male mating success differed between wild-type and transgenic individuals. Our predictive demographic model based on fitness components closely matched the rate of transgenic phenotype loss observed in the long-term study, thereby supporting its utility for studies assessing evolutionary outcomes of escaped or released genetically modified animals. © 2015 The Author(s).

Intracellular compartmentalization and degradation of free polymannose oligosaccharides released during glycoprotein biosynthesis.

PubMed

Moore, S E; Spiro, R G

1994-04-29

The intracellular site for the degradation of free polymannose oligosaccharides released during glycoprotein biosynthesis has been studied by permeabilizing the plasma membrane of metabolically radiolabeled HepG2 cells with streptolysin O. This pore-forming agent permitted us to examine the breakdown in both the cytosolic and vesicular compartments of the previously recognized (Anumula, K. R., and Spiro, R. G. (1983) J. Biol. Chem. 258, 15274-15282) polymannose components terminating in a di-N-acetylchitobiose sequence (OS-Glc-NAc2) or a single N-acetylglucosamine residue (OS-Glc-NAc1) residue. Pulse-chase studies indicated that although the OS-GlcNAc2 saccharides were about equally distributed between vesicles and cytosol and rapidly disappeared after reaching the Man8 stage, the OS-GlcNAc1 species were found predominantly in the extravesicular compartment and there underwent a distinctive demannosylation sequence resulting in the formation of a Man5GlcNAc isomer (Man alpha 1-->2Man alpha 1-->2Man alpha 1-->3(Man alpha 1-->6)Man beta 1-->4GlcNAc) which was different from the product of Golgi processing enzymes. Further trimming of this cytosolic limit product required its translocation into a vesicular compartment, believed to be lysosomes, in which Man2-4GlcNAc components appeared as the metabolic chase progressed. The accumulation of Glc1Man5GlcNAc in the cytosol during the chase suggested that glucose interferes with the cytosolic-vesicular transfer and this became even more evident by the pronounced pile-up of extravesicular Glc3Man5GlcNAc when the cells were incubated in the presence of castanospermine. Although the biological significance and mechanism of free polymannose oligosaccharide entry into the cytosol is not yet known, the possibility that it may reflect an endoplasmic reticulum-situated degradative process of glycoproteins merits consideration.

Intracellular synthesis, processing, and transport of proteins encoded by ORFs 5 to 7 of porcine reproductive and respiratory syndrome virus.

PubMed

Mardassi, H; Massie, B; Dea, S

1996-07-01

Porcine Reproductive and Respiratory Syndrome Virus (PRRSV), a small enveloped virus containing a positive-strand RNA genome, possesses at least three major structural proteins designated N, M, and E. The N protein is considered as the major component of the nucleocapsid, whereas M and E are membrane-associated. Previous studies using peptide-specific antibodies assigned these proteins to ORFs 7, 6, and 5, respectively. In the present report, monospecific antisera raised against Escherichia coli-expressed ORFs 5, 6, and 7 products were used to study the synthesis and processing of PRRSV structural proteins in the highly permissive MARC-145 cell line. Treatment of viral proteins with various glycosidases showed that only E was modified by N-linked glycans. Pulse-chase experiments revealed that intracellular transport of the major envelope glycoprotein was delayed in the premedial Golgi compartment. During the first 30 min of chase, E undergoes a gradual downward shift of its apparent molecular weight, thought to result from trimming of the mannose-rich glycan structures. Once E is transported to the medial Golgi or proximal elements, some molecules undergo complete processing of all their high-mannose N-linked oligosaccharides to complex type, while in other molecules only a fraction of N-linked glycans are terminally glycosylated. These two differentially glycosylated forms of E were found to be incorporated into extracellular virions. In cells and virions, both M and E were shown to occur in heterodimeric complexes linked by disulfide bonds. The oligomerization process, as analyzed from pulse-chase experiments, showed that M and E are incorporated into M-E complexes with different kinetics and efficiencies, in a fashion similar to their counterparts in equine arteritis virus. Apparently, all steps of E protein N-glycans processing proceed after its association with M which occurs in the endoplasmic reticulum (ER). In the infected cells, E and M appear highly membrane-associated, while N is predominantly cytosolic.

Black carbon, particle number concentration and nitrogen oxide emission factors of random in-use vehicles measured with the on-road chasing method

NASA Astrophysics Data System (ADS)

Ježek, I.; Katrašnik, T.; Westerdahl, D.; Močnik, G.

2015-06-01

The chasing method was used in an on-road measurement campaign, and emission factors (EF) of black carbon (BC), particle number (PN) and nitrogen oxides (NOx) were determined for 139 individual vehicles of different types encountered on the roads. The aggregated results provide EFs for BC, NOx and PN for three vehicle categories: goods vehicles, gasoline and diesel passenger cars. This is the first on-road measurement study where BC EFs of numerous individual diesel cars were determined in real-world driving conditions. We found good agreement between EFs of goods vehicles determined in this campaign and the results of previous studies that used either chasing or remote sensing measurement techniques. The composition of the sampled car fleet determined from the national vehicle registry information is reflective of Eurostat statistical data on the Slovenian and European vehicle fleet. The median BC EF of diesel and gasoline cars that were in use for less than 5 years, decreased by 60 and 47% from those in use for 5-10 years, respectively, the median NOx and PN EFs, of goods vehicles that were in use for less than five years, decreased from those in use for 5-10 years by 52 and 67%, respectively. The influence of engine maximum power of the measured EFs showed an increase in NOx EF from least to more powerful vehicles with diesel engines. Finally a disproportionate contribution of high emitters to the total emissions of the measured fleet was found; the top 25% of emitting diesel cars contributed 63, 47 and 61% of BC, NOx and PN emissions respectively. With the combination of relatively simple on-road measurements with sophisticated post processing individual vehicles EF can be determined and useful information about the fleet emissions can be obtained by exactly representing vehicles which contribute disproportionally to vehicle fleet emissions; and monitor how the numerous emission reduction approaches are reflected in on-road driving conditions.

Energetics and evasion dynamics of large predators and prey: pumas vs. hounds

PubMed Central

Wilmers, Christopher C.; Williams, Terrie M.

2017-01-01

Quantification of fine-scale movement, performance, and energetics of hunting by large carnivores is critical for understanding the physiological underpinnings of trophic interactions. This is particularly challenging for wide-ranging terrestrial canid and felid predators, which can each affect ecosystem structure through distinct hunting modes. To compare free-ranging pursuit and escape performance from group-hunting and solitary predators in unprecedented detail, we calibrated and deployed accelerometer-GPS collars during predator-prey chase sequences using packs of hound dogs (Canis lupus familiaris, 26 kg, n = 4–5 per chase) pursuing simultaneously instrumented solitary pumas (Puma concolor, 60 kg, n = 2). We then reconstructed chase paths, speed and turning angle profiles, and energy demands for hounds and pumas to examine performance and physiological constraints associated with cursorial and cryptic hunting modes, respectively. Interaction dynamics revealed how pumas successfully utilized terrain (e.g., fleeing up steep, wooded hillsides) as well as evasive maneuvers (e.g., jumping into trees, running in figure-8 patterns) to increase their escape distance from the overall faster hounds (avg. 2.3× faster). These adaptive strategies were essential to evasion in light of the mean 1.6× higher mass-specific energetic costs of the chase for pumas compared to hounds (mean: 0.76 vs. 1.29 kJ kg−1 min−1, respectively). On an instantaneous basis, escapes were more costly for pumas, requiring exercise at ≥90% of predicted \\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{upgreek} \\usepackage{mathrsfs} \\setlength{\\oddsidemargin}{-69pt} \\begin{document} }{}$\\dot {\\mathrm{V }}{\\mathrm{O}}_{2\\mathrm{MAX}}$\\end{document}V ˙O2MAX and consuming as much energy per minute as approximately 5 min of active hunting. Our results demonstrate the marked investment of energy for evasion by a large, solitary carnivore and the advantage of dynamic maneuvers to postpone being overtaken by group-hunting canids. PMID:28828280

Techniques for Modeling Human Performance in Synthetic Environments: A Supplementary Review

DTIC Science & Technology

2003-06-01

hours of practice and study is often mentioned (e.g., Simon & Chase, 1973)—the size of the dataset has made it difficult indeed to study real-time...cognition acts as a production system offers a framework for studying the human mind. Theory adds more precision to frameworks, and describes data...stress. If synthetic forces are to be used to test doctrine, the effect of training on expertise must be included. Expert behavior has been studied

What ET will look like and why should we care

NASA Astrophysics Data System (ADS)

Shostak, Seth

2010-11-01

Our experiments to find extraterrestrial life are predicated on the assumption that it is most likely to be found on so-called "habitable worlds." These are planets and moons where surface liquid water exists, and atmospheres of light gases are found. Our searches presume that life on other worlds has a biochemistry at least somewhat similar to our own. While these postulates might be our best guide for finding biology, they could be misleading us in the search for extraterrestrial intelligence (SETI). Timescale arguments suggest that shortly after a sentient species invents the technology for communication, it develops synthetic intelligence. Consequently, SETI's targeted searches of star systems that might have habitable planets in the conventional sense may be chasing a very short-lived prey. In this paper, we discuss what the implications of post-biological intelligence might have in directing our SETI experiments.

Panic, slash, or crash-Do black swans flap in stock markets?

NASA Astrophysics Data System (ADS)

Chen, Dar-Hsin; Huang, Han-Lin

2018-02-01

Stock transaction data typically present a time series that exhibits a somewhat confusing trend, making it difficult to issue any form of crisis warning. This study employs Fourier spectrum analysis to clearly show manic and irrational investors chasing prices. When clustering generates an enormous amount of unstable power, the result is a stock market collapsing into a danger area that can be taken as a warning signal. We thus take the Dow Jones Index as a typical stock market and employ daily data from 1994-2015. This study finds the investors' purchasing power through certain thresholds, analyses the performance characteristics of the spectrum, and denotes when a stock market is in a most serious crisis stage and in a second most serious correction stage. The result of our study indicates that the warning signal accurately measures a stock market crash that can be applicable to the Dow Jones Index, Nasdaq Index, and Germany ADX Index and to the emerging markets of Bovespa Index (Brazil) and Shanghai Index (China). Furthermore, this study provides a quantitative reference concerning the depth of market crashes.

Questions without Movement: A Study of Cantonese-Speaking Children with and without Specific Language Impairment.

ERIC Educational Resources Information Center

Wong, Anita M.-Y.; Leonard, Laurence B.; Fletcher, Paul; Stokes, Stephanie F.

2004-01-01

English-speaking children with specific language impairment (SLI) appear to have special difficulty in the use of who-object questions (e.g., Who is the girl chasing?). It has been argued that problems related to grammatical movement may be responsible for this difficulty. However, it is also possible that the lower frequency of who-object…

The Paper Chase in the Workplace: The Use and Value of Vocational Education and Training Qualifications to Employers. A Paper for the Workplace Learning Special Interest Group.

ERIC Educational Resources Information Center

Malloch, Margaret; Martino, John; Waterhouse, Peter; Townsend, Ray

Australian employers' appraisal and use of vocational education and training (VET) qualifications were examined through case studies of 15 small, medium, and large organizations in 8 of Australia's "old" and "new" economy industries. Data were collected through interviews with management/employer representatives, middle…

Three-Station Three-dimensional Bolus-Chase MR Angiography with Real-time Fluoroscopic Tracking

PubMed Central

Johnson, Casey P.; Weavers, Paul T.; Borisch, Eric A.; Grimm, Roger C.; Hulshizer, Thomas C.; LaPlante, Christine C.; Rossman, Phillip J.; Glockner, James F.; Young, Phillip M.

2014-01-01

Purpose To determine the feasibility of using real-time fluoroscopic tracking for bolus-chase magnetic resonance (MR) angiography of peripheral vasculature to image three stations from the aortoiliac bifurcation to the pedal arteries. Materials and Methods This prospective study was institutional review board approved and HIPAA compliant. Eight healthy volunteers (three men; mean age, 48 years; age range, 30–81 years) and 13 patients suspected of having peripheral arterial disease (five men; mean age, 67 years; age range, 47–81 years) were enrolled and provided informed consent. All subjects were imaged with the fluoroscopic tracking MR angiographic protocol. Ten patients also underwent a clinical computed tomographic (CT) angiographic runoff examination. Two readers scored the MR angiographic studies for vessel signal intensity and sharpness and presence of confounding artifacts and venous contamination at 35 arterial segments. Mean aggregate scores were assessed. The paired MR angiographic and CT angiographic studies also were scored for visualization of disease, reader confidence, and overall diagnostic quality and were compared by using a Wilcoxon signed rank test. Results Real-time fluoroscopic tracking performed well technically in all studies. Vessel segments were scored good to excellent in all but the following categories: For vessel signal intensity and sharpness, the abdominal aorta, iliac arteries, distal plantar arteries, and plantar arch were scored as fair to good; and for presence of confounding artifacts, the abdominal aorta and iliac arteries were scored as fair. The MR angiograms and CT angiograms did not differ significantly in any scoring category (reader 1: P = .50, .39, and .39; reader 2: P = .41, .61, and .33, respectively). CT scores were substantially better in 20% (four of 20) and 25% (five of 20) of the pooled evaluations for the visualization of disease and overall image quality categories, respectively, versus 5% (one of 20) for MR scores in both categories. Conclusion Three-station bolus-chase MR angiography with real-time fluoroscopic tracking provided high-spatial-resolution arteriograms of the peripheral vasculature, enabled precise triggering of table motion, and compared well with CT angiograms. © RSNA, 2014 Online supplemental material is available for this article. PMID:24635676

Biosynthesis and processing of the mannose receptor in human macrophages.

PubMed

Lennartz, M R; Cole, F S; Stahl, P D

1989-02-05

The biosynthesis and processing of the human mannose receptor has been studied in monocyte-derived macrophages. Adherent cells were labeled for 60 min with Trans35S (a mixture of 35S-labeled methionine and cysteine), chased, and subjected to immunoprecipitation by antibody raised against the human placental receptor. The antibody immunoprecipitated a single protein of molecular mass 162 kDa; precipitation of the labeled receptor could be inhibited by placental receptor. The results presented demonstrate that the receptor is synthesized as a 154-kDa precursor which is processed to 162 kDa in 90 min. The precursor is a glycoprotein bearing endoglycosidase H-sensitive oligosaccharides; the 162-kDa form is endoglycosidase H-resistant but peptide:N-glycanase-sensitive. Desialylation of the mannose receptor with neuraminidase generates a protein which is recognized by peanut agglutinin, a lectin that specifically binds desialylated O-linked oligosaccharides. Thus, the human macrophage mannose receptor bears both N- and O-linked oligosaccharide chains. Newly synthesized mannose receptor exhibits a half-life of 33 h as determined by pulse-chase studies. This indicates that on the average, each molecule of receptor recycles between the cell surface and endosomes hundreds of times before degradation.

A comparative analysis of errors in long-term econometric forecasts

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tepel, R.

1986-04-01

The growing body of literature that documents forecast accuracy falls generally into two parts. The first is prescriptive and is carried out by modelers who use simulation analysis as a tool for model improvement. These studies are ex post, that is, they make use of known values for exogenous variables and generate an error measure wholly attributable to the model. The second type of analysis is descriptive and seeks to measure errors, identify patterns among errors and variables and compare forecasts from different sources. Most descriptive studies use an ex ante approach, that is, they evaluate model outputs based onmore » estimated (or forecasted) exogenous variables. In this case, it is the forecasting process, rather than the model, that is under scrutiny. This paper uses an ex ante approach to measure errors in forecast series prepared by Data Resources Incorporated (DRI), Wharton Econometric Forecasting Associates (Wharton), and Chase Econometrics (Chase) and to determine if systematic patterns of errors can be discerned between services, types of variables (by degree of aggregation), length of forecast and time at which the forecast is made. Errors are measured as the percent difference between actual and forecasted values for the historical period of 1971 to 1983.« less

Predator pursuit strategies: how do falcons and hawks chase prey?

NASA Astrophysics Data System (ADS)

Kane, Suzanne Amador; Zamani, Marjon; Fulton, Andrew; Rosenthal, Lee

2014-03-01

This study reports on experiments on falcons, goshawks and red-tailed hawks wearing miniature videocameras mounted on their backs or heads while pursuing flying or ground-based prey. Videos of hunts recorded by the raptors were analyzed to determine apparent prey positions on their visual fields during pursuits. These video data then were interpreted using computer simulations of pursuit steering laws observed in insects and mammals. A comparison of the empirical and modeling data indicates that falcons use cues due to the apparent motion of prey on the falcon's visual field to track and capture flying prey via a form of motion camouflage. The falcons also were found to maintain their prey's image at visual angles consistent with using their shallow fovea. Results for goshawks and red-tailed hawks were analyzed for a comparative study of how pursuits of ground-based prey by accipeters and buteos differ from those used by falcons chasing flying prey. These results should prove relevant for understanding the coevolution of pursuit and evasion, as well as the development of computer models of predation on flocks,and the integration of sensory and locomotion systems in biomimetic robots.

A pilot study of contralateral homonymous muscle activity simulated electrical stimulation in chronic hemiplegia.

PubMed

Osu, Rieko; Otaka, Yohei; Ushiba, Junichi; Sakata, Sachiko; Yamaguchi, Tomofumi; Fujiwara, Toshiyuki; Kondo, Kunitsugu; Liu, Meigen

2012-01-01

For the recovery of hemiparetic hand function, a therapy was developed called contralateral homonymous muscle activity stimulated electrical stimulation (CHASE), which combines electrical stimulation and bilateral movements, and its feasibility was studied in three chronic stroke patients with severe hand hemiparesis. Patients with a subcortical lesion were asked to extend their wrist and fingers bilaterally while an electromyogram (EMG) was recorded from the extensor carpi radialis (ECR) muscle in the unaffected hand. Electric stimulation was applied to the homonymous wrist and finger extensors of the affected side. The intensity of the electrical stimulation was computed based on the EMG and scaled so that the movements of the paretic hand looked similar to those of the unaffected side. The patients received 30-minutes of therapy per day for 2 weeks. Improvement in the active range of motion of wrist extension was observed for all patients. There was a decrease in the scores of modified Ashworth scale in the flexors. Fugl-Meyer assessment scores of motor function of the upper extremities improved in two of the patients. The results suggest a positive outcome can be obtained using the CHASE system for upper extremity rehabilitation of patients with severe hemiplegia.

Financial stress, attitudes toward money, and scores on a Dream Inventory.

PubMed

Kroth, Jerry; Mann, Sonia; Cervantes, Carolina; Jaffe, Matthew; Ristic, Vera

2010-08-01

During stock market losses in 2009 and high unemployment, ratings on the KJP Dream Inventory were correlated with factors of the Money Attitude Scale and items on the Contemporary Financial Stress Inventory for 71 graduate students in Counseling Psychology and Education. Correlations were significant for Retention on the Money Attitude Scale with Dissociative Avoidance (-.31), Dreams of falling (.26), Risk-taking in dreams (.24), and Dreaming of being chased (.28). Also, ratings for the Money Attitude Scale of Distrust correlated with Discontentedness in dreams (.33) and Dreams of being chased (.26), Repetitive trauma (.33), Nightmares (.30), and Recurring nightmares (.35). Concern about retention in graduate school due to finances correlated with recalled frequencies of nightmares (.27) and dreams of flying (.25).

76 FR 77593 - Proposed Exemptions From Certain Prohibited Transaction Restrictions

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-13

...This document contains notices of pendency before the Department of Labor (the Department) of proposed exemptions from certain of the prohibited transaction restrictions of the Employee Retirement Income Security Act of 1974 (ERISA or the Act) and/or the Internal Revenue Code of 1986 (the Code). This notice includes the following proposed exemptions: D-11517, JPMorgan Chase & Co. and its Current and Future Affiliates and Subsidiaries (JPMorgan Chase); D- 11579, Delaware Charter Guarantee & Trust Co. d\\b\\a\\ Principle Trust Company (Principle Trust); D-11628, Aztec Well Servicing Company and Related Companies Medical Plan Trust Fund (the Plan); D-11669, Genzyme Corporation 401(k) Plan (the Plan or the Applicant); and Retirement Program for Employees of EnPro Industries (the Plan), D-11662 et al.

Chasing the Mirage: a grounded theory of the clinical reasoning processes that Registered Nurses use to recognize delirium.

PubMed

El Hussein, Mohamed; Hirst, Sandra

2016-02-01

The aim of this study was to construct a grounded theory that explains the clinical reasoning processes that registered nurses use to recognize delirium in older adults in acute care hospitals. Delirium is under-recognized in acute hospital settings, this may stem from underdeveloped clinical reasoning processes. Little is known about registered nurses' (RNs) clinical reasoning processes in complex situations such as delirium recognition. A grounded theory approach was used to analyse interview data about the clinical reasoning processes of RNs in acute hospital settings. Seventeen RNs were recruited. Concurrent data collection and comparative analysis and theoretical sampling were conducted in 2013-2014. The core category to emerge from the data was 'chasing the mirage', which describes RNs' clinical reasoning processes to recognize delirium during their interaction with older adults. Understanding the reasoning that contributes to delirium under-recognition provides a strategy by which, this problem can be brought to the forefront of RNs' awareness and intervention. Delirium recognition will contribute to quality care for older adults. © 2015 John Wiley & Sons Ltd.

Are emissions of black carbon from gasoline vehicles overestimated? Real-time, in situ measurement of black carbon emission factors.

PubMed

Wang, Yang; Xing, Zhenyu; Zhao, Shuhui; Zheng, Mei; Mu, Chao; Du, Ke

2016-03-15

Accurately quantifying black carbon (BC) emission factors (EFs) is a prerequisite for estimation of BC emission inventory. BC EFs determined by measuring BC at the roadside or chasing a vehicle on-road may introduce large uncertainty for low emission vehicles. In this study, BC concentrations were measured inside the tailpipe of gasoline vehicles with different engine sizes under different driving modes to determine the respective EFs. BC EFs ranged from 0.005-7.14 mg/kg-fuel under the speeds of 20-70 km/h, 0.05-28.95 mg/kg-fuel under the accelerations of 0.5-1.5m/s(2). Although the water vapor in the sampling stream could result in an average of 12% negative bias, the BC EFs are significantly lower than the published results obtained with roadside or chasing vehicle measurement. It is suggested to conduct measurement at the tailpipe of gasoline vehicles instead of in the atmosphere behind the vehicles to reduce the uncertainty from fluctuation in ambient BC concentration. Copyright © 2015 Elsevier B.V. All rights reserved.

Cell Fate of Müller Cells During Photoreceptor Regeneration in an N-Methyl-N-nitrosourea-Induced Retinal Degeneration Model of Zebrafish.

PubMed

Ogai, Kazuhiro; Hisano, Suguru; Sugitani, Kayo; Koriyama, Yoshiki; Kato, Satoru

2016-01-01

Zebrafish can regenerate several organs such as the tail fin, heart, central nervous system, and photoreceptors. Very recently, a study has demonstrated the photoreceptor regeneration in the alkylating agent N-methyl-N-nitrosourea (MNU)-induced retinal degeneration (RD) zebrafish model, in which whole photoreceptors are lost within a week after MNU treatment and then regenerated within a month. The research has also shown massive proliferation of Müller cells within a week. To address the question of whether proliferating Müller cells are the source of regenerating photoreceptors, which remains unknown in the MNU-induced zebrafish RD model, we employed a BrdU pulse-chase technique to label the proliferating cells within a week after MNU treatment. As a result of the BrdU pulse-chase technique, a number of BrdU(+) cells were observed in the outer nuclear layer as well as the inner nuclear layer. This implies that regenerating photoreceptors are derived from proliferating Müller cells in the zebrafish MNU-induced RD model.

Carbon-13 NMR studies of salt shock-induced carbohydrate turnover in the marine cyanobacterium Agmenellum quadruplicatum

NASA Technical Reports Server (NTRS)

Tel-Or, E.; Spath, S.; Packer, L.; Mehlhorn, R. J.

1986-01-01

Carbon turnover in response to abrupt changes in salinity, including the mobilization of glycogen for use in osmoregulation was studied with pulse-chase strategies utilizing nuclear magnetic resonance (NMR)-silent and NMR-detectable 12C and 13C isotopes, respectively. Growth of Agmenellum quadruplicatum in 30%-enriched 13C bicarbonate provided sufficient NMR-detectability of intracellular organic osmoregulants for these studies. A comparison of NMR spectra of intact cells and their ethanol extracts showed that the intact cell data were suitable for quantitative work, and, when combined with ESR measurements of cell volumes, yielded intracellular glucosylglycerol concentrations without disrupting the cells. NMR pulse-chase experiments were used to show that 13C-enriched glycogen, which had previously been accumulated by the cells under nitrogen-limited growth at low salinities, could be utilized for the synthesis of glucosylglycerol when the cells were abruptly transferred to hypersaline media, but only in the light. It was also shown that the accumulation of glucosylglycerol in the light occurred on a time scale similar to that of cell doubling. Depletion of glucosylglycerol when cells abruptly transferred to lower salinities appeared to be rapid--the intracellular pool of this osmoregulant was decreased 2-fold within 2 hours of hypotonic shock.

Where Will the Triangle Look for It? Attributing False Beliefs to a Geometric Shape at 17 Months

ERIC Educational Resources Information Center

Surian, Luca; Geraci, Alessandra

2012-01-01

Prior research on implicit mind-reading skills has focussed on how infants anticipate other persons' actions. This study investigated whether 11- and 17-month-olds spontaneously attribute false beliefs (FB) even to a simple animated geometric shape. Infants were shown a triangle chasing a disk through a tunnel. Using an eye-tracker, we found that…

Recovery of spinning satellites

NASA Technical Reports Server (NTRS)

Coppey, J. M.; Mahaffey, W. R.

1977-01-01

The behavior of a space tug and a spinning satellite in a coupled configuration was simulated and analyzed. A docking concept was developed to investigate the requirements pertaining to the design of a docking interface. Sensing techniques and control requirements for the chase vehicle were studied to assess the feasibility of an automatic docking. The effects of nutation dampers and liquid propellant slosh motion upon the docking transient were investigated.

Chemical Carcinogen-Induced Changes in tRNA Metabolism in Human Cells.

DTIC Science & Technology

1981-11-01

the resolution and quantitation of modified ucleosides in the urine of cancer patients would not be particularly useful for the cell culture studies...Comparison of nucleic acid catabolism by normal human fibroblasts and fibroblasts transformed with methylazoxymethyl alcohol ( MAMA ),an activated...catabolite in long-term, pulse-chase experiments. However, the kinetics of catabolism differed, in that only the MAMA -transformed cells had generated

“Chasing a Ghost”: Factors that Influence Primary Care Physicians to Follow Up on Incidental Imaging Findings

PubMed Central

Bugos, Eva K.; Langlotz, Curtis P.; Frasso, Rosemary

2016-01-01

Purpose To explore provider and patient characteristics that influence how primary care providers (PCPs) communicate and manage incidental imaging findings. Materials and Methods This HIPAA-compliant study was approved by the institutional review board. Through semistructured interviews, researchers explored concerns and perspectives of 30 PCPs on receiving and acting on incidental imaging findings. Open-ended questions were designed to elicit a range of responses rather than quantifiable data. Thematic codes were developed and explicitly defined. Three research assistants independently coded all 30 deidentified transcripts and resolved discrepancies (κ = 0.85). Codes pertaining to PCP and patient characteristics were organized into an explanatory model. Results Some PCPs felt compelled but frustrated to pursue costly follow-up for incidental imaging findings of limited clinical importance. Other PCPs did not act on findings that were unfamiliar or occurred in an unusual clinical context when follow-up recommendations were not given; the challenges of researching the clinical importance of these findings or seeking specialist consultation led to inaction. Some PCPs reported using a uniform approach to communicate and manage incidental findings, while others adapted their approach to the patient and the finding. Sometimes PCP characteristics such as follow-up style superseded patient characteristics. At other times patient characteristics such as health literacy superseded PCP characteristics. Conclusion PCPs cited a variety of objective and subjective factors that influence how they communicate and manage incidental imaging findings. These results suggest that some patients may receive inappropriate follow-up of incidental imaging findings and present an opportunity for radiologists to help PCPs and patients to best use the information conveyed in imaging reports. © RSNA, 2016 Online supplemental material is available for this article. PMID:27192458

"Chasing a Ghost": Factors that Influence Primary Care Physicians to Follow Up on Incidental Imaging Findings.

PubMed

Zafar, Hanna M; Bugos, Eva K; Langlotz, Curtis P; Frasso, Rosemary

2016-11-01

Purpose To explore provider and patient characteristics that influence how primary care providers (PCPs) communicate and manage incidental imaging findings. Materials and Methods This HIPAA-compliant study was approved by the institutional review board. Through semistructured interviews, researchers explored concerns and perspectives of 30 PCPs on receiving and acting on incidental imaging findings. Open-ended questions were designed to elicit a range of responses rather than quantifiable data. Thematic codes were developed and explicitly defined. Three research assistants independently coded all 30 deidentified transcripts and resolved discrepancies (κ = 0.85). Codes pertaining to PCP and patient characteristics were organized into an explanatory model. Results Some PCPs felt compelled but frustrated to pursue costly follow-up for incidental imaging findings of limited clinical importance. Other PCPs did not act on findings that were unfamiliar or occurred in an unusual clinical context when follow-up recommendations were not given; the challenges of researching the clinical importance of these findings or seeking specialist consultation led to inaction. Some PCPs reported using a uniform approach to communicate and manage incidental findings, while others adapted their approach to the patient and the finding. Sometimes PCP characteristics such as follow-up style superseded patient characteristics. At other times patient characteristics such as health literacy superseded PCP characteristics. Conclusion PCPs cited a variety of objective and subjective factors that influence how they communicate and manage incidental imaging findings. These results suggest that some patients may receive inappropriate follow-up of incidental imaging findings and present an opportunity for radiologists to help PCPs and patients to best use the information conveyed in imaging reports. © RSNA, 2016 Online supplemental material is available for this article.

Cryptic sexual conflict in gift-giving insects: chasing the chase-away.

PubMed

Sakaluk, Scott K; Avery, Rachel L; Weddle, Carie B

2006-01-01

The chase-away model of sexual selection posits that elaborate male sexual displays arise because they exploit preexisting biases in females' sensory systems and induce females to mate in a suboptimal manner. An essential element of this hypothesis is that such manipulation should quickly lead to female resistance to male displays. Nuptial food gifts may be a frequent conduit by which males attempt to influence the mating behavior of females against females' own reproductive interests. In decorated crickets Gryllodes sigillatus, such inducements come in the form of a spermatophylax, a gelatinous mass forming part of the male's spermatophore and consumed by the female after mating. We conducted experiments in which spermatophylaxes obtained from male G. sigillatus were offered as novel food gifts to females of a non-gift-giving species (Acheta domesticus) having no evolutionary history of spermatophylax consumption. Female A. domesticus that were allowed to consume the spermatophylax took significantly longer to remate than when given no such opportunity. In contrast, when female G. sigillatus were prevented from consuming their partners' nuptial gifts, there was no difference in their propensity to remate relative to females permitted to consume a food gift after mating. These results suggest that the spermatophylax synthesized by male G. sigillatus contains substances designed to inhibit the sexual receptivity of their mates but that female G. sigillatus have evolved reduced responsiveness to these substances.

Development and testing of a prototype tool for integrated assessment of chemical status in marine environments.

PubMed

Andersen, Jesper H; Murray, Ciarán; Larsen, Martin M; Green, Norman; Høgåsen, Tore; Dahlgren, Elin; Garnaga-Budrė, Galina; Gustavson, Kim; Haarich, Michael; Kallenbach, Emilie M F; Mannio, Jaakko; Strand, Jakob; Korpinen, Samuli

2016-02-01

We report the development and application of a prototype tool for integrated assessment of chemical status in aquatic environments based on substance- and matrix-specific environmental assessment criteria (thresholds). The Chemical Status Assessment Tool (CHASE) integrates data on hazardous substances in water, sediments and biota as well as bio-effect indicators and is based on a substance- or bio-effect-specific calculation of a 'contamination ratio' being the ratio between an observed concentration and a threshold value. Values <1.0 indicate areas potentially 'unaffected', while values >1.0 indicate areas potentially 'affected'. These ratios are combined within matrices, i.e. for water, sediment and biota and for biological effects. The overall assessment used a 'one out, all out principle' with regard to each matrix. The CHASE tool was tested in the Baltic Sea and the North Sea in 376 assessment units. In the former, the chemical status was >1.0 in practically all areas indicating that all areas assessed were potentially affected. The North Sea included areas classified as unaffected or affected. The CHASE tool can in combination with temporal trend assessments of individual substances be advantageous for use in remedial action plans and, in particular, for the science-based evaluation of the status and for determining which specific substances are responsible for a status as potentially affected.

A minimal model of predator–swarm interactions

PubMed Central

Chen, Yuxin; Kolokolnikov, Theodore

2014-01-01

We propose a minimal model of predator–swarm interactions which captures many of the essential dynamics observed in nature. Different outcomes are observed depending on the predator strength. For a ‘weak’ predator, the swarm is able to escape the predator completely. As the strength is increased, the predator is able to catch up with the swarm as a whole, but the individual prey is able to escape by ‘confusing’ the predator: the prey forms a ring with the predator at the centre. For higher predator strength, complex chasing dynamics are observed which can become chaotic. For even higher strength, the predator is able to successfully capture the prey. Our model is simple enough to be amenable to a full mathematical analysis, which is used to predict the shape of the swarm as well as the resulting predator–prey dynamics as a function of model parameters. We show that, as the predator strength is increased, there is a transition (owing to a Hopf bifurcation) from confusion state to chasing dynamics, and we compute the threshold analytically. Our analysis indicates that the swarming behaviour is not helpful in avoiding the predator, suggesting that there are other reasons why the species may swarm. The complex shape of the swarm in our model during the chasing dynamics is similar to the shape of a flock of sheep avoiding a shepherd. PMID:24598204

A minimal model of predator-swarm interactions.

PubMed

Chen, Yuxin; Kolokolnikov, Theodore

2014-05-06

We propose a minimal model of predator-swarm interactions which captures many of the essential dynamics observed in nature. Different outcomes are observed depending on the predator strength. For a 'weak' predator, the swarm is able to escape the predator completely. As the strength is increased, the predator is able to catch up with the swarm as a whole, but the individual prey is able to escape by 'confusing' the predator: the prey forms a ring with the predator at the centre. For higher predator strength, complex chasing dynamics are observed which can become chaotic. For even higher strength, the predator is able to successfully capture the prey. Our model is simple enough to be amenable to a full mathematical analysis, which is used to predict the shape of the swarm as well as the resulting predator-prey dynamics as a function of model parameters. We show that, as the predator strength is increased, there is a transition (owing to a Hopf bifurcation) from confusion state to chasing dynamics, and we compute the threshold analytically. Our analysis indicates that the swarming behaviour is not helpful in avoiding the predator, suggesting that there are other reasons why the species may swarm. The complex shape of the swarm in our model during the chasing dynamics is similar to the shape of a flock of sheep avoiding a shepherd.

Jason Roadman | NREL

Science.gov Websites

using trained raptors, metrology, storm chasing, and wind tunnel testing of atmospheric turbulence. He Wind tunnel testing of atmospheric turbulence Education B.S. in Aerospace Engineering from Virginia

Chasing Exoplanets

NASA Technical Reports Server (NTRS)

Jenkins, Jon M.

2017-01-01

NASA's Kepler Mission was launched in March 2009 as NASA's first mission capable of finding Earth-size planets orbiting in the habitable zone of Sun-like stars, that range of distances for which liquid water would pool on the surface of a rocky planet. Kepler has discovered over 1000 planets and over 4600 candidates, many of them as small as the Earth. Today, Kepler's amazing success seems to be a fait accompli to those unfamiliar with her history. But twenty years ago, there were no planets known outside our solar system, and few people believed it was possible to detect tiny Earth-size planets orbiting other stars. Motivating NASA to select Kepler for launch required a confluence of the right detector technology, advances in signal processing and algorithms, and the power of supercomputing.

How moths escape bats: predicting outcomes of predator-prey interactions.

PubMed

Corcoran, Aaron J; Conner, William E

2016-09-01

What determines whether fleeing prey escape from attacking predators? To answer this question, biologists have developed mathematical models that incorporate attack geometries, pursuit and escape trajectories, and kinematics of predator and prey. These models have rarely been tested using data from actual predator-prey encounters. To address this problem, we recorded multi-camera infrared videography of bat-insect interactions in a large outdoor enclosure. We documented 235 attacks by four Myotis volans bats on a variety of moths. Bat and moth flight trajectories from 50 high-quality attacks were reconstructed in 3-D. Despite having higher maximum velocity, deceleration and overall turning ability, bats only captured evasive prey in 69 of 184 attacks (37.5%); bats captured nearly all moths not evading attack (50 of 51; 98%). Logistic regression indicated that prey radial acceleration and escape angle were the most important predictors of escape success (44 of 50 attacks correctly classified; 88%). We found partial support for the turning gambit mathematical model; however, it underestimated the escape threshold by 25% of prey velocity and did not account for prey escape angle. Whereas most prey escaping strikes flee away from predators, moths typically escaped chasing bats by turning with high radial acceleration toward 'safety zones' that flank the predator. This strategy may be widespread in prey engaged in chases. Based on these findings, we developed a novel geometrical model of predation. We discuss implications of this model for the co-evolution of predator and prey kinematics and pursuit and escape strategies. © 2016. Published by The Company of Biologists Ltd.

The Priming of Amylose Synthesis in Arabidopsis Leaves1

PubMed Central

Zeeman, Samuel C.; Smith, Steven M.; Smith, Alison M.

2002-01-01

We investigated the mechanism of amylose synthesis in Arabidopsis leaves using 14C-labeling techniques. First, we tested the hypothesis that short malto-oligosaccharides (MOS) may act as primers for granule-bound starch synthase I. We found increased amylose synthesis in isolated starch granules supplied with ADP[14C]glucose (ADP[14C]Glc) and MOS compared with granules supplied with ADP[14C]Glc but no MOS. Furthermore, using a MOS-accumulating mutant (dpe1), we found that more amylose was synthesized than in the wild type, correlating with the amount of MOS in vivo. When wild-type and mutant plants were tested in conditions where both lines had similar MOS contents, no difference in amylose synthesis was observed. We also tested the hypothesis that branches of amylopectin might serve as the primers for granule-bound starch synthase I. In this model, elongated branches of amylopectin are subsequently cleaved to form amylose. We conducted pulse-chase experiments, supplying a pulse of ADP[14C]Glc to isolated starch granules or 14CO2 to intact plants, followed by a chase period in unlabeled substrate. We detected no transfer of label from the amylopectin fraction to the amylose fraction of starch either in isolated starch granules or in intact leaves, despite varying the time course of the experiments and using a mutant line (sex4) in which high-amylose starch is synthesized. We therefore find no evidence for amylopectin-primed amylose synthesis in Arabidopsis. We propose that MOS are the primers for amylose synthesis in Arabidopsis leaves. PMID:11891261

Association of Regulatory Boards of Optometry

MedlinePlus

... Fraud contact number) or https://www.chase.com/credit-cards/customer-service . In addition, individuals may also consider reviewing their current credit reports at https://www.annualcreditreport.com/index.action . ...

Energetic cost of feeding territories in an Hawaiian honeycreeper.

PubMed

Carpenter, F Lynn; MacMillen, Richard E

1976-09-01

By analysis of time budgets the daily energy expenditure in territorial individuals of a Hawaiian honeycreeper (Vestiaria coccinea, Fam. Drepanididae) were estimated during the nonbreeding season and compared to that of nonterritorial individuals. The mean rise in living costs was 2.3 kcal/24 h or 17% of the nonterritorial energy budget. The most costly territorial behavior was advertisement rather than chasing, and total territorial cost was seen to be little affected by the number of intruders or the size of the territory. These results are compared with data on feeding (nonbreeding) territories of other nectar-feeding birds. The suggestion is made that hummingbirds may be more likely to develop nonbreeding territorial behavior in any set of environmental circumstances than are honeycreepers because of relatively lower total cost of advertisement plus chasing.

NRC, SPI, and chasing arrows: Is there common ground

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rabasca, L.

After negotiating for 15 months, issuing three white papers, and conducting consumer research, the National Recycling Coalition (NRC, Washington, DC) and the Society of the Plastics Industry, Inc. (SPI, Washington, DC), have agreed to disagree on the use of the familiar chasing arrows logo in SPI's seven-number resin identification code. The desired end result of the talks and debates was supposed to be a plan to change legislation requiring 39 states to use SPI's current resin identification code and a commitment to remove the old code from durable goods and flexible packaging. Ultimately, these actions could have improved markets formore » polyethylene terephthalate (PET) and high-density polyethylene (HDPE) by reducing contamination caused by confusion over what is actually recycled versus what is merely recyclable.« less

Whichever way the wind blows, scientists and engineers try to find ways to protect people and property

NASA Astrophysics Data System (ADS)

Showstack, Randy

Timothy Marshall, a failure and damage consultant with the Haag Engineering Company in Dallas, Texas, possesses a passion for storm chasing. On the afternoon of May 3, 1999, with atmospheric conditions creating a potentially explosive situation, Marshall drove several hours north to central Oklahoma to spot tornadoes. A storm started blowing up near Lawton and moved parallel to Interstate 44, with Marshall ahead of it in his Chevy pickup. He parked on the Newcastle overpass bridge, videotaping the long-tracked twister for later study At 7:04 p.m. local time, with the vortex now just one mile away and moving straight toward him, it started appearing three-dimensional, debris and projectiles flying about, the tornado roaring like freight trains, wind howling, red mud raining down, and things “getting a little out of hand,” Marshall recalled. He drove out of its path, only to watch the tornado tear through the suburban streets and houses of Moore, on its way to Oklahoma City.

Responding to inequities: gorillas try to maintain their competitive advantage during play fights

PubMed Central

Van Leeuwen, Edwin J. C.; Zimmermann, Elke; Ross, Marina Davila

2011-01-01

Humans respond to unfair situations in various ways. Experimental research has revealed that non-human species also respond to unequal situations in the form of inequity aversions when they have the disadvantage. The current study focused on play fights in gorillas to explore for the first time, to our knowledge, if/how non-human species respond to inequities in natural social settings. Hitting causes a naturally occurring inequity among individuals and here it was specifically assessed how the hitters and their partners engaged in play chases that followed the hitting. The results of this work showed that the hitters significantly more often moved first to run away immediately after the encounter than their partners. These findings provide evidence that non-human species respond to inequities by trying to maintain their competitive advantages. We conclude that non-human primates, like humans, may show different responses to inequities and that they may modify them depending on if they have the advantage or the disadvantage. PMID:20630892

Responding to inequities: gorillas try to maintain their competitive advantage during play fights.

PubMed

Van Leeuwen, Edwin J C; Zimmermann, Elke; Ross, Marina Davila

2011-02-23

Humans respond to unfair situations in various ways. Experimental research has revealed that non-human species also respond to unequal situations in the form of inequity aversions when they have the disadvantage. The current study focused on play fights in gorillas to explore for the first time, to our knowledge, if/how non-human species respond to inequities in natural social settings. Hitting causes a naturally occurring inequity among individuals and here it was specifically assessed how the hitters and their partners engaged in play chases that followed the hitting. The results of this work showed that the hitters significantly more often moved first to run away immediately after the encounter than their partners. These findings provide evidence that non-human species respond to inequities by trying to maintain their competitive advantages. We conclude that non-human primates, like humans, may show different responses to inequities and that they may modify them depending on if they have the advantage or the disadvantage.

F-18 chase craft with NASA test pilots Schneider and Fulton

NASA Technical Reports Server (NTRS)

1992-01-01

Ed Schneider, (left), is the project pilot for the F-18 High Angle of Attack program at NASA's Dryden Flight Research Center, Edwards, California. He has been a NASA research pilot at Dryden since 1983. In addition to his assignment with the F-18 High Angle of Attack program, Schneider is a project pilot for the F-15B aeronautical research aircraft, the NASA NB-52B launch aircraft, and the SR-71 'Blackbird' aircraft. He is a Fellow and was the 1994 President of the Society of Experimental Test Pilots. In 1996 he was awarded the NASA Exceptional Service Medal. Schneider is seen here with Fitzhugh L. Fulton Jr., (right), who was a civilian research pilot at Dryden. from August 1, 1966, until July 3, 1986, following 23 years of service as a pilot in the U.S. Air Force. Fulton was the project pilot on all early tests of the 747 Shuttle Carrier Aircraft (SCA) used to air launch the Space Shuttle prototype Enterprise in the Approach and Landing Tests (ALT) at Dryden in l977. For his work in the ALT program, Fulton received NASA's Exceptional Service Medal. He also received the Exceptional Service Medal again in 1983 for flying the 747 SCA during the European tour of the Space Shuttle Enterprise. During his career at Dryden, Fulton was project pilot on NASA's NB-52B launch aircraft used to air launch a variety of piloted and unpiloted research aircraft, including the X-15s and lifting bodies. He flew the XB-70 prototype supersonic bomber on both NASA-USAF tests and NASA research flights during the late 1960s, attaining speeds exceeding Mach 3. He was also a project pilot on the YF-12A and YF-12C research program from April 14, 1969, until September 25, 1978. The F/A-18 Hornet seen behind them is used primarily as a safety chase and support aircraft at NASA's Dryden Flight Research Center, Edwards, Calif. As support aircraft, the F-18's are used for safety chase, pilot proficiency and aerial photography. As a safety chase aircraft, F-18's, flown by research pilots, accompany research missions as another 'set of eyes' to visually observe the research event, experiment or test to help make sure the flights are carried out safely. The 'chase' pilots are in constant communication with the research pilots and mission control to report abnormalities that may be seen from the support aircraft. Pilots must also stay proficient by flying a certain number of missions per month. F-18's are used for this. A two-seat support aircraft is also used when research missions require an engineer or photographer on the flights.

Chase the direct impact of rainfall into groundwater in Mt. Fuji from multiple analyses including microbial DNA

NASA Astrophysics Data System (ADS)

Kato, Kenji; Sugiyama, Ayumi; Nagaosa, Kazuyo; Tsujimura, Maki

2016-04-01

A huge amount of groundwater is stored in subsurface environment of Mt. Fuji, the largest volcanic mountain in Japan. Based on the concept of piston flow transport of groundwater an apparent residence time was estimated to ca. 30 years by 36Cl/Cl ratio (Tosaki et al., 2011). However, this number represents an averaged value of the residence time of groundwater which had been mixed before it flushes out. We chased signatures of direct impact of rainfall into groundwater to elucidate the routes of groundwater, employing three different tracers; stable isotopic analysis (delta 18O), chemical analysis (concentration of silica) and microbial DNA analysis. Though chemical analysis of groundwater shows an averaged value of the examined water which was blended by various water with different sources and routes in subsurface environment, microbial DNA analysis may suggest the place where they originated, which may give information of the source and transport routes of the water examined. Throughout the in situ observation of four rainfall events showed that stable oxygen isotopic ratio of spring water and shallow groundwater obtained from 726m a.s.l. where the average recharge height of rainfall was between 1500 and 1800 m became higher than the values before a torrential rainfall, and the concentration of silica decreased after this event when rainfall exceeded 300 mm in precipitation of an event. In addition, the density of Prokaryotes in spring water apparently increased. Those changes did not appear when rainfall did not exceed 100 mm per event. Thus, findings shown above indicated a direct impact of rainfall into shallow groundwater, which appeared within a few weeks of torrential rainfall in the studied geological setting. In addition, increase in the density of Archaea observed at deep groundwater after the torrential rainfall suggested an enlargement of the strength of piston flow transport through the penetration of rainfall into deep groundwater. This finding was supported by difference in constituents of Archaea by predominance of Halobacteriales and Methanobacteriales, which were thought to be relatively tightly embedded in geological layer and were extracted from the environment to the examined groundwater. Microbial DNA thus could give information about the route of groundwater, which was never elucidated by analysis of chemical materials dissolved in groundwater.

Above-real-time training (ARTT) improves transfer to a simulated flight control task.

PubMed

Donderi, D C; Niall, Keith K; Fish, Karyn; Goldstein, Benjamin

2012-06-01

The aim of this study was to measure the effects of above-real-time-training (ARTT) speed and screen resolution on a simulated flight control task. ARTT has been shown to improve transfer to the criterion task in some military simulation experiments. We tested training speed and screen resolution in a project, sponsored by Defence Research and Development Canada, to develop components for prototype air mission simulators. For this study, 54 participants used a single-screen PC-based flight simulation program to learn to chase and catch an F-18A fighter jet with another F-18A while controlling the chase aircraft with a throttle and side-stick controller. Screen resolution was varied between participants, and training speed was varied factorially across two sessions within participants. Pretest and posttest trials were at high resolution and criterion (900 knots) speed. Posttest performance was best with high screen resolution training and when one ARTT training session was followed by a session of criterion speed training. ARTT followed by criterion training improves performance on a visual-motor coordination task. We think that ARTT influences known facilitators of transfer, including similarity to the criterion task and contextual interference. Use high-screen resolution, start with ARTT, and finish with criterion speed training when preparing a mission simulation.

75 FR 51293 - [Disaster Declaration greek-i12272 and greek-i12273

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-19

... on 08/10/2010, Private Non- Profit organizations that provide essential services of governmental... Counties: Atchison, Brown, Butler, Chase, Clay, Cloud, Comanche, Doniphan, Ellis, Franklin, Greenwood...

2. Overview of site, looking southeast Naval Air Station ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. Overview of site, looking southeast - Naval Air Station Chase Field, Building 1001, Independence Street, .45 mile south of intersection of Texas State Highway & Independence Street, Beeville, Bee County, TX

7. Overview of site, looking southwest Naval Air Station ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

7. Overview of site, looking southwest - Naval Air Station Chase Field, Building 1001, Independence Street, .45 mile south of intersection of Texas State Highway & Independence Street, Beeville, Bee County, TX

1. Overview of site, looking northwest Naval Air Station ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. Overview of site, looking northwest - Naval Air Station Chase Field, Building 1001, Independence Street, .45 mile south of intersection of Texas State Highway & Independence Street, Beeville, Bee County, TX

8. Overview of site, looking northeast Naval Air Station ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

8. Overview of site, looking northeast - Naval Air Station Chase Field, Building 1001, Independence Street, .45 mile south of intersection of Texas State Highway & Independence Street, Beeville, Bee County, TX

ARC-2007-ACD07-0189-018

NASA Image and Video Library

2007-10-02

International Space Station (ISS) National Laboratory Workshop L-R Lynn Harper, Ames and Baruch Blumberg, Nobel Laureate, Fox Chase Cancer Center during talk on Science on the international Space Station, Past and Future.

EC65-0649

NASA Image and Video Library

1965-04-26

LLRV flight #1-16-61F with Bell 47 Helicopter providing chase support. The use of chase planes was a critical part of flight research well before the establishment of what was then called the NACA Muroc Flight Test Unit in September 1947 (now the NASA Dryden Flight Research Center). They act as a second set of eyes for the research pilot, warning him of any problems. When test flights of the LLRV began in October 1964, chase support for the vehicle was supplied by a Bell 47 helicopter. It could hover close by, providing information such as altitude and descent rate. LLRV test operations were phased out in late 1966 and early 1967. When Apollo planning was underway in 1960, NASA was looking for a simulator to profile the descent to the Moon's surface. Three concepts surfaced: an electronic simulator, a tethered device, and the ambitious Dryden contribution, a free-flying vehicle. All three became serious projects, but eventually the NASA Flight Research Center’s (FRC) Lunar Landing Research Vehicle (LLRV) became the most significant one. After conceptual planning and meetings with engineers from Bell Aerosystems Company, Buffalo, N.Y., NASA FRC issued a $3.6 million production contract awarded in 1963, for delivery of the first of two vehicles for flight studies. Built of tubular aluminum alloy like a giant four-legged bedstead, the vehicle was to simulate a lunar landing profile from around 1500 feet to the Moon’s surface. The LLRV had a turbofan engine mounted vertically in a gimbal, with 4200 pounds of thrust. The engine, lifted the vehicle up to the test altitude and was then throttled back to support five-sixths of the vehicle's weight, thus simulating the reduced gravity of the Moon. Two lift rockets with thrust that could be varied from 100 to 500 pounds handled the LLRV's rate of descent and horizontal translations. Sixteen smaller rockets, mounted in pairs, gave the pilot control in pitch, yaw, and roll. The pilot’s platform extended forward between t

Pulse-chase Analysis of N-linked Sugar Chains from Glycoproteins in Mammalian Cells

PubMed Central

Avezov, Edward; Ron, Efrat; Izenshtein, Yana; Adan, Yosef; Lederkremer, Gerardo Z.

2010-01-01

Attachment of the Glc3Man9GlcNAc2 precursor oligosaccharide to nascent polypeptides in the ER is a common modification for secretory proteins. Although this modification was implicated in several biological processes, additional aspects of its function are emerging, with recent evidence of its role in the production of signals for glycoprotein quality control and trafficking. Thus, phenomena related to N-linked glycans and their processing are being intensively investigated. Methods that have been recently developed for proteomic analysis have greatly improved the characterization of glycoprotein N-linked glycans. Nevertheless, they do not provide insight into the dynamics of the sugar chain processing involved. For this, labeling and pulse-chase analysis protocols are used that are usually complex and give very low yields. We describe here a simple method for the isolation and analysis of metabolically labeled N-linked oligosaccharides. The protocol is based on labeling of cells with [2-3H] mannose, denaturing lysis and enzymatic release of the oligosaccharides from either a specifically immunoprecipitated protein of interest or from the general glycoprotein pool by sequential treatments with endo H and N-glycosidase F, followed by molecular filtration (Amicon). In this method the isolated oligosaccharides serve as an input for HPLC analysis, which allows discrimination between various glycan structures according to the number of monosaccharide units comprising them, with a resolution of a single monosaccharide. Using this method we were able to study high mannose N-linked oligosaccharide profiles of total cell glycoproteins after pulse-chase in normal conditions and under proteasome inhibition. These profiles were compared to those obtained from an immunoprecipitated ER-associated degradation (ERAD) substrate. Our results suggest that most NIH 3T3 cellular glycoproteins are relatively stable and that most of their oligosaccharides are trimmed to Man9-8GlcNAc2. In contrast, unstable ERAD substrates are trimmed to Man6-5GlcNAc2 and glycoproteins bearing these species accumulate upon inhibition of proteasomal degradation. PMID:20424595

Pulse-chase analysis of N-linked sugar chains from glycoproteins in mammalian cells.

PubMed

Avezov, Edward; Ron, Efrat; Izenshtein, Yana; Adan, Yosef; Lederkremer, Gerardo Z

2010-04-27

Attachment of the Glc3Man9GlcNAc2 precursor oligosaccharide to nascent polypeptides in the ER is a common modification for secretory proteins. Although this modification was implicated in several biological processes, additional aspects of its function are emerging, with recent evidence of its role in the production of signals for glycoprotein quality control and trafficking. Thus, phenomena related to N-linked glycans and their processing are being intensively investigated. Methods that have been recently developed for proteomic analysis have greatly improved the characterization of glycoprotein N-linked glycans. Nevertheless, they do not provide insight into the dynamics of the sugar chain processing involved. For this, labeling and pulse-chase analysis protocols are used that are usually complex and give very low yields. We describe here a simple method for the isolation and analysis of metabolically labeled N-linked oligosaccharides. The protocol is based on labeling of cells with [2-(3)H] mannose, denaturing lysis and enzymatic release of the oligosaccharides from either a specifically immunoprecipitated protein of interest or from the general glycoprotein pool by sequential treatments with endo H and N-glycosidase F, followed by molecular filtration (Amicon). In this method the isolated oligosaccharides serve as an input for HPLC analysis, which allows discrimination between various glycan structures according to the number of monosaccharide units comprising them, with a resolution of a single monosaccharide. Using this method we were able to study high mannose N-linked oligosaccharide profiles of total cell glycoproteins after pulse-chase in normal conditions and under proteasome inhibition. These profiles were compared to those obtained from an immunoprecipitated ER-associated degradation (ERAD) substrate. Our results suggest that most NIH 3T3 cellular glycoproteins are relatively stable and that most of their oligosaccharides are trimmed to Man9-8GlcNAc2. In contrast, unstable ERAD substrates are trimmed to Man6-5GlcNAc2 and glycoproteins bearing these species accumulate upon inhibition of proteasomal degradation.

Genetic and isotope ratio mass spectrometric evidence for the occurrence of starch degradation and cycling in illuminated Arabidopsis leaves

PubMed Central

Baslam, Marouane; Baroja-Fernández, Edurne; Ricarte-Bermejo, Adriana; Sánchez-López, Ángela María; Aranjuelo, Iker; Bahaji, Abdellatif; Muñoz, Francisco José; Almagro, Goizeder; Pujol, Pablo; Galarza, Regina; Teixidor, Pilar; Pozueta-Romero, Javier

2017-01-01

Although there is a great wealth of data supporting the occurrence of simultaneous synthesis and breakdown of storage carbohydrate in many organisms, previous 13CO2 pulse-chase based studies indicated that starch degradation does not operate in illuminated Arabidopsis leaves. Here we show that leaves of gwd, sex4, bam4, bam1/bam3 and amy3/isa3/lda starch breakdown mutants accumulate higher levels of starch than wild type (WT) leaves when cultured under continuous light (CL) conditions. We also show that leaves of CL grown dpe1 plants impaired in the plastidic disproportionating enzyme accumulate higher levels of maltotriose than WT leaves, the overall data providing evidence for the occurrence of extensive starch degradation in illuminated leaves. Moreover, we show that leaves of CL grown mex1/pglct plants impaired in the chloroplastic maltose and glucose transporters display a severe dwarf phenotype and accumulate high levels of maltose, strongly indicating that the MEX1 and pGlcT transporters are involved in the export of starch breakdown products to the cytosol to support growth during illumination. To investigate whether starch breakdown products can be recycled back to starch during illumination through a mechanism involving ADP-glucose pyrophosphorylase (AGP) we conducted kinetic analyses of the stable isotope carbon composition (δ13C) in starch of leaves of 13CO2 pulsed-chased WT and AGP lacking aps1 plants. Notably, the rate of increase of δ13C in starch of aps1 leaves during the pulse was exceedingly higher than that of WT leaves. Furthermore, δ13C decline in starch of aps1 leaves during the chase was much faster than that of WT leaves, which provides strong evidence for the occurrence of AGP-mediated cycling of starch breakdown products in illuminated Arabidopsis leaves. PMID:28152100

Black carbon, particle number concentration and nitrogen oxide emission factors of random in-use vehicles measured with the on-road chasing method

NASA Astrophysics Data System (ADS)

Ježek, I.; Katrašnik, T.; Westerdahl, D.; Močnik, G.

2015-10-01

The chasing method was used in an on-road measurement campaign, and emission factors (EF) of black carbon (BC), particle number (PN) and nitrogen oxides (NOx) were determined for 139 individual vehicles of different types encountered on the roads. The aggregated results provide EFs for BC, NOx and PN for three vehicle categories: goods vehicles, gasoline and diesel passenger cars. This is the first on-road measurement study where BC EFs of numerous individual diesel cars were determined in real-world driving conditions. We found good agreement between EFs of goods vehicles determined in this campaign and the results of previous studies that used either chasing or remote-sensing measurement techniques. The composition of the sampled car fleet determined from the national vehicle registry information is reflective of Eurostat statistical data on the Slovenian and European vehicle fleet. The median BC EF of diesel and gasoline cars that were in use for less than 5 years decreased by 60 and 47 % from those in use for 5-10 years, respectively; the median NOx and PN EFs of goods vehicles that were in use for less than 5 years decreased from those in use for 5-10 years by 52 and 67 %, respectively. Surprisingly, we found an increase of BC EFs in the newer goods vehicle fleet compared to the 5-10-year old one. The influence of engine maximum power of the measured EFs showed an increase in NOx EF from least to more powerful vehicles with diesel engines. Finally, a disproportionate contribution of high emitters to the total emissions of the measured fleet was found; the top 25 % of emitting diesel cars contributed 63, 47 and 61 % of BC, NOx and PN emissions respectively. With the combination of relatively simple on-road measurements and sophisticated post processing, individual vehicle EF can be determined and useful information about the fleet emissions can be obtained by exactly representing vehicles which contribute disproportionally to vehicle fleet emissions; and monitor how the numerous emission reduction approaches are reflected in on-road driving conditions.

Do male breeding displays function to attract mates or defend territories? The explanatory role of mate and site fidelity

USGS Publications Warehouse

Lanctot, Richard B.; Sandercock, B.K.; Kempenaers, Bart

2000-01-01

Many shorebirds show elaborate breeding displays that include aerial flights and ground displays accompanied by song. The mate attraction hypothesis suggests that breeding displays function to attract mates and maintain pair bonds, whereas the territory defense hypothesis suggests breeding displays function in defining and defending nesting and feeding territories. We tested these hypotheses in the Western Sandpiper (Calidris mauri) by contrasting the duration and level of male breeding displays among pairs that differed in their mate and site fidelity. As predicted by the mate attraction hypothesis, males performed the highest number of song sequences during pair formation, and males paired with their mate of a prior year sang less than males paired to new mates. Further, sitefaithful males mated to a new but experienced mate displayed significantly more than remated males or males new to the area. This suggests a male's prior familiarity with an area and his neighbors does not lessen his display rate as was predicted under the territory defense hypothesis. Limited support for the territory defense hypothesis came from observations of males performing breeding displays with neighboring males along nest territory boundaries. This behavior was short-lived, however, as males abandoned nesting areas after pair-formation and used adjacent or disjointed feeding areas during egg-laying and incubation. Male aggression (i.e., aerial and ground chases), as opposed to breeding displays, appeared to be the principal means of maintaining territory boundaries. Indeed, the rate at which males chased other males remained fairly constant and high throughout the breeding season. Male chasing behavior may also serve as a paternity guard to protect against extra-pair copulations. Our study also found that a female's prior breeding experience in an area correlated with a reduced display rate by her mate, particularly if that mate was new to the area. This indicates female characteristics may not only drive nest initiation, as has been shown in other studies, but are important in determining the duration and extent of male display.

Healthy Weight: You Can Do It, Too

MedlinePlus

... diet") and gets regular exercise. Photos: Russell Morgan Russell Morgan changed the way he eats and exercises, ... a recent eight-month period, public health expert Russell Morgan, 66, of Chevy Chase, Md., dropped 60 ...

EC79-11481

NASA Image and Video Library

1979-08-20

A chase plane view of the tufts on the KC-135 winglet. The use of tufts in flight research dates back to the early days of the NACA, and remains an effective means of observing airflow even today. In this procedure, rows of strings are attached to an airplane's surface, with one end of each string taped to the airplane and the other end free to swing about in the airflow. The movements of the tufts are photographed by on-board cameras or a chase plane. If the tufts are arrayed in neat rows, as seen here, then the airflow is smooth over the airplane's surface. If, however, they are moving about violently, it suggests turbulent airflow. Such motions may indicate high drag, flow separation (such as in a stall), or buffeting. In some cases, tufts will actually point forward, indicating the airflow has reversed direction.

Evidence for carboxyl-terminal processing and glycolipid-anchoring of human carcinoembryonic antigen.

PubMed

Takami, N; Misumi, Y; Kuroki, M; Matsuoka, Y; Ikehara, Y

1988-09-05

We have investigated the post-translational modification of carcinoembryonic antigen (CEA) for membrane-anchoring in QGP-1 cells derived from a human pancreatic carcinoma. Pulse-chase experiments with [3H]leucine demonstrated that CEA was initially synthesized as a precursor form with Mr 150,000 having N-linked high-mannose-type oligosaccharides, which was then converted to a mature form with Mr 200,000 containing the complex type sugar chains. The mature protein thus labeled was found to be released from the cell surface by treatment with phosphatidylinositol-specific phospholipase C, suggesting that CEA is a phosphatidylinositol-linked membrane protein. This was confirmed by metabolic incorporation into CEA of 3H-labeled compounds such as ethanolamine, myo-inositol, palmitic acid, and stearic acid. The 3H-labeled fatty acids incorporated were specifically removed from the protein by nitrous acid deamination as well as by phosphatidylinositol-specific phospholipase C treatment. Since the available cDNA sequence predicts that CEA contains a single methionine residue only in its carboxyl-terminal hydrophobic domain, processing of the carboxyl terminus was examined by pulse-chase experiments with [35S]methionine. It was found that CEA with Mr 150,000 was initially labeled with [35S]methionine but its radioactivity was immediately lost with chase. Taken together, these results suggest that CEA is anchored to the membrane by simultaneously occurring proteolysis of the carboxyl terminus and replacement by the glycophospholipid immediately after the synthesis.

Photosynthetic carbon metabolism in seagrasses C-labeling evidence for the c(3) pathway.

PubMed

Andrews, T J; Abel, K M

1979-04-01

The delta(13)C values of several seagrasses were considerably less negative than those of terrestrial C(3) plants and tended toward those of terrestrial C(4) plants. However, for Thalassia hemprichii (Ehrenb.) Aschers and Halophila spinulosa (R. Br.) Aschers, phosphoglycerate and other C(3) cycle intermediates predominated among the early labeled products of photosynthesis in (14)C-labeled seawater (more than 90% at the earliest times) and the labeling pattern at longer times was brought about by the operation of the C(3) pathway. Malate and aspartate together accounted for only a minor fraction of the total fixed label at all times and the kinetic data of this labeling were not at all consistent with these compounds being early intermediates in seagrass photosynthesis. Pulse-chase (14)C-labeling studies further substantiated these conclusions. Significant labeling of photorespiratory intermediates was observed in all experiments. The kinetics of total fixation of label during some steady-state and pulse-chase experiments suggested that there may be an intermediate pool of inorganic carbon of variable size closely associated with the leaves, either externally or internally. Such a pool may be one cause for the C(4)-like carbon isotope ratios of seagrasses.

Structural syntactic prediction measured with ELAN: evidence from ERPs.

PubMed

Fonteneau, Elisabeth

2013-02-08

The current study used event-related potentials (ERPs) to investigate how and when argument structure information is used during the processing of sentences with a filler-gap dependency. We hypothesize that one specific property - animacy (living vs. non-living) - is used by the parser during the building of the syntactic structure. Participants heard sentences that were rated off-line as having an expected noun (Who did the Lion King chase the caravan with?) or an unexpected noun (Who did Lion King chase the animal with?). This prediction is based on the animacy properties relation between the wh-word and the noun in the object position. ERPs from the noun in the unexpected condition (animal) elicited a typical Early Left Anterior Negativity (ELAN)/P600 complex compared to the noun in the expected condition (caravan). Firstly, these results demonstrate that the ELAN reflects not only grammatical category violation but also animacy property expectations in filler-gap dependency. Secondly, our data suggests that the language comprehension system is able to make detailed predictions about aspects of the upcoming words to build up the syntactic structure. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

The Built Environment Is a Microbial Wasteland

PubMed Central

2016-01-01

ABSTRACT Humanity’s transition from the outdoor environment to the built environment (BE) has reduced our exposure to microbial diversity. The relative importance of factors that contribute to the composition of human-dominated BE microbial communities remains largely unknown. In their article in this issue, Chase and colleagues (J. Chase, J. Fouquier, M. Zare, D. L. Sonderegger, R. Knight, S. T. Kelley, J. Siegel, and J. G. Caporaso, mSystems 1(2):e00022-16, 2016, http://dx.doi.org/10.1128/mSystems.00022-16) present an office building study in which they controlled for environmental factors, geography, surface material, sampling location, and human interaction type. They found that surface location and geography were the strongest factors contributing to microbial community structure, while surface material had little effect. Even in the absence of direct human interaction, BE surfaces were composed of 25 to 30% human skin-associated taxa. The authors demonstrate how technical variation across sequencing runs is a major issue, especially in BE work, where the biomass is often low and the potential for PCR contaminants is high. Overall, the authors conclude that BE surfaces are desert-like environments where microbes passively accumulate. PMID:27832216

Copper-Based Torpedo Guidance Wire: Applications and Environmental Considerations

DTIC Science & Technology

2013-06-01

on day 91 had an additional toxicity evaluation using the developing larvae of the Mediterranean mussel, Mytilus galloprovincialis, concurrently...recent study conducted in 2008 did not. 4.3.1.3 Baird’s Beaked Whale (Berardius bairdii) Baird’s beaked whales have a diet consisting of benthic fish... Mediterranean are formed as Cuvier’s beaked whales chase down and feed upon benthic prey (Woodside, David, Frantzis, and Hooker, 2006). One of the easiest 38

Role of Conserved Oligomeric Golgi Complex in the Abnormalities of Glycoprotein Processing in Breast Cancer Cells

DTIC Science & Technology

2006-05-01

terminal oligosaccharide units serve as highly specific biological recognition molecules implicated in major regulatory processes of the cell...treatment or mock-treated for 9 days. To study the glycosylation process in COG complex depleted cells series of Pulse -Chase experiments have been...DAMD17-03-1-0243 TITLE: Role of the Conserved Oligomeric Golgi Complex in the Abnormalities of Glycoprotein Processing in Breast Cancer

Chasing down the triple-negative myeloproliferative neoplasms: Implications for molecular diagnostics.

PubMed

Langabeer, Stephen E

2016-01-01

The majority of patients with classical myeloproliferative neoplasms (MPN) of polycythemia vera, essential thrombocythemia, and primary myelofibrosis harbor distinct disease-driving mutations within the JAK2 , CALR , or MPL genes. The term triple-negative has been recently applied to those MPN without evidence of these consistent mutations, prompting whole or targeted exome sequencing approaches to determine the driver mutational status of this subgroup. These strategies have identified numerous novel mutations that occur in alternative exons of both JAK2 and MPL , the majority of which result in functional activation. Current molecular diagnostic approaches may possess insufficient coverage to detect these alternative mutations, prompting further consideration of targeted exon sequencing into routine diagnostic practice. How to incorporate these illuminating findings into the expanding molecular diagnostic algorithm for MPN requires continual attention.

DefenseLink Special: Doolittle Raid, April 18, 1942

Science.gov Websites

enhanced viewing {Flash 8} Macromedia Flash Player 8 required Download free Macromedia Flash Player Download free Internet Explorer DOOLITTLE RAIDERS – Retired Lt. Col. Chase Nelson, a Doolittle Raider

9. Interior of Building 1040 (gym), looking west Naval ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

9. Interior of Building 1040 (gym), looking west - Naval Air Station Chase Field, Building 1040, Enterprise Street, .37 mile South-Southeast of intersection of Texas State Highway 202 & Independence Street, Beeville, Bee County, TX

10. Interior of Building 1040 (chapel), looking north Naval ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

10. Interior of Building 1040 (chapel), looking north - Naval Air Station Chase Field, Building 1040, Enterprise Street, .37 mile South-Southeast of intersection of Texas State Highway 202 & Independence Street, Beeville, Bee County, TX

8. Overview of Building 1009, looking south Naval Air ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

8. Overview of Building 1009, looking south - Naval Air Station Chase Field, Building 1009, Essex Street, .68 mile South-southeast of intersection of Texas State Highway 202 & Independence Street, Beeville, Bee County, TX

Deaths among criminal suspects, law enforcement officers, civilians, and prison inmates: a coroner-based study.

PubMed

Koehler, Steven A; Weiss, Hank; Songer, Thomas J; Rozin, Leon; Shakir, Abdulrezzak; Ladham, Shaun; Omalu, Bennet; Dominick, Joseph; Wecht, Cyril H

2003-12-01

During the interaction between a criminal suspect and a law enforcement officer, the risk of death to the suspect, police, or civilians is increased. Unfortunately, very little information is available on the death risks arising from this interaction. This study provides an assessment of the risk of death to law enforcement officers, suspects, and bystanders by separating the interactions into the following 4 phases: (1) events prior to and during arrest; (2) police pursuits or chases; (3) transport of the suspects; and (4) during incarceration. A 5-year (1994-1998) retrospective coroner-based study of all deaths that occurred during these 4 phases was conducted in Allegheny County, Pennsylvania. A total of 77 cases were identified; 14 deaths (18.1%) occurred prior to or during arrest, 10 (12.9%) during police chases, 2 (2.6%) occurred while the actors were being transported, and 51 (66.2%) during incarceration. The majority of cases (98.7%) were males, blacks (63.6%), and single (50.6%). The respective risks of death by phase were prearrest/arrest, 6.5 per 100,000 arrests; transport, 0.93 deaths per 100,000 arrests; and incarceration, 268 deaths per 100,000 inmates. Study showed the following: (1) risk of death to offenders was greatest during police pursuits; (2) the risks during arrests are not insignificant and involved an officer being threatened with a weapon in one-third of the events; and (3) deaths among inmates were primarily due to natural causes.

6. West side of Building 1001 (administration building), looking southeast ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

6. West side of Building 1001 (administration building), looking southeast - Naval Air Station Chase Field, Building 1001, Independence Street, .45 mile south of intersection of Texas State Highway & Independence Street, Beeville, Bee County, TX

5. Interior of Building 1042 (brig), cell, looking northeast ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

5. Interior of Building 1042 (brig), cell, looking northeast - Naval Air Station Chase Field, Building 1042, Ofstie Road, .6 mile South-Southeast of intersection of Texas State Highway 202 & Independence Street, Beeville, Bee County, TX

4. South side of Building 1001 (administration building), looking north ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. South side of Building 1001 (administration building), looking north - Naval Air Station Chase Field, Building 1001, Independence Street, .45 mile south of intersection of Texas State Highway & Independence Street, Beeville, Bee County, TX

3. East side of Building 1001 (administration building), looking west ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

3. East side of Building 1001 (administration building), looking west - Naval Air Station Chase Field, Building 1001, Independence Street, .45 mile south of intersection of Texas State Highway & Independence Street, Beeville, Bee County, TX

3. Southwest side of Building 1042 (brig), looking northeast ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

3. Southwest side of Building 1042 (brig), looking northeast - Naval Air Station Chase Field, Building 1042, Ofstie Road, .6 mile South-Southeast of intersection of Texas State Highway 202 & Independence Street, Beeville, Bee County, TX

8. Southwest side of Building 1040 (chapel), looking northeast ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

8. Southwest side of Building 1040 (chapel), looking northeast - Naval Air Station Chase Field, Building 1040, Enterprise Street, .37 mile South-Southeast of intersection of Texas State Highway 202 & Independence Street, Beeville, Bee County, TX

4. Southwest side of Building 1042 (brig), looking northeast ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. Southwest side of Building 1042 (brig), looking northeast - Naval Air Station Chase Field, Building 1042, Ofstie Road, .6 mile South-Southeast of intersection of Texas State Highway 202 & Independence Street, Beeville, Bee County, TX

2. Southeast side of Building 1042 (brig), looking northwest ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. Southeast side of Building 1042 (brig), looking northwest - Naval Air Station Chase Field, Building 1042, Ofstie Road, .6 mile South-Southeast of intersection of Texas State Highway 202 & Independence Street, Beeville, Bee County, TX

5. North side of Building 1001 (administration building), looking southeast ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

5. North side of Building 1001 (administration building), looking southeast - Naval Air Station Chase Field, Building 1001, Independence Street, .45 mile south of intersection of Texas State Highway & Independence Street, Beeville, Bee County, TX

1. Northeast side of Building 1042 (brig), looking southwest ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. Northeast side of Building 1042 (brig), looking southwest - Naval Air Station Chase Field, Building 1042, Ofstie Road, .6 mile South-Southeast of intersection of Texas State Highway 202 & Independence Street, Beeville, Bee County, TX

Autonomous docking ground demonstration

NASA Technical Reports Server (NTRS)

Lamkin, Steve L.; Le, Thomas Quan; Othon, L. T.; Prather, Joseph L.; Eick, Richard E.; Baxter, Jim M.; Boyd, M. G.; Clark, Fred D.; Spehar, Peter T.; Teters, Rebecca T.

1991-01-01

The Autonomous Docking Ground Demonstration is an evaluation of the laser sensor system to support the docking phase (12 ft to contact) when operated in conjunction with the guidance, navigation, and control (GN&C) software. The docking mechanism being used was developed for the Apollo/Soyuz Test Program. This demonstration will be conducted using the 6-DOF Dynamic Test System (DTS). The DTS simulates the Space Station Freedom as the stationary or target vehicle and the Orbiter as the active or chase vehicle. For this demonstration, the laser sensor will be mounted on the target vehicle and the retroflectors will be on the chase vehicle. This arrangement was chosen to prevent potential damage to the laser. The laser sensor system, GN&C, and 6-DOF DTS will be operated closed-loop. Initial conditions to simulate vehicle misalignments, translational and rotational, will be introduced within the constraints of the systems involved.

Toxic leucoencephalopathy after 'chasing the dragon'.

PubMed

Singh, Rajinder; Saini, Monica

2015-06-01

Toxic leucoencephalopathy (TLE) is a rare neurological complication of heroin abuse. 'Chasing the dragon' is an inhalational mode of heroin abuse that originated in Southeast Asia. Intriguingly, no cases of TLE have been reported from this region, although the inhalational mode of heroin abuse is common. We herein report the case of a middle-aged man with a history of polysubstance abuse who presented with progressive neurological symptoms and progressed to an uncommunicative state. While the initial impression was that of iatrogenic parkinsonism, diffuse leucoencephalopathy with sparing of the cerebellum was noted on magnetic resonance imaging. In view of his history of inhalational heroin abuse close to the onset of the neurological symptoms, a diagnosis of TLE was made. No clinical improvement was noted with administration of a dopaminergic agent. This is the first known case of delayed TLE following heroin inhalation from Southeast Asia with the unusual feature of cerebellar sparing.

Fringe chasing by three-point spatial phase shifting for discrimination of the motion direction in the long-range homodyne laser Doppler vibrometry

NASA Astrophysics Data System (ADS)

Daemi, Mohammad Hossein; Rasouli, Saifollah

2018-07-01

In this work, a three-point spatial phase shifting (SPS) method is implemented for chasing of the moving interference fringes in the homodyne laser Doppler vibrometry (HoLDV). By the use of SPS method, we remove disability of the HoLDV in the discrimination of the motion direction for long-range displacements. From the phase increments histogram, phase unwrapping tolerance value is selected, and adequacy of the data acquisition rate and required bandwidth limit are determined. Also in this paper, a detailed investigation on the effect of detectors positioning errors and influence of the Gaussian profile of the interfering beams on the measurements are presented. Performance of the method is verified by measuring a given harmonic vibration produced by a loudspeaker. Also, by the proposed method, vibration of mounting system of a disk laser gain medium is characterized.

KC-135A in flight - closeup of winglet with attached tufts

NASA Technical Reports Server (NTRS)

1979-01-01

A chase plane view of the tufts on the KC-135 winglet. The use of tufts in flight research dates back to the early days of the NACA, and remains an effective means of observing airflow even today. In this procedure, rows of strings are attached to an airplane's surface, with one end of each string taped to the airplane and the other end free to swing about in the airflow. The movements of the tufts are photographed by on-board cameras or a chase plane. If the tufts are arrayed in neat rows, as seen here, then the airflow is smooth over the airplane's surface. If, however, they are moving about violently, it suggests turbulent airflow. Such motions may indicate high drag, flow separation (such as in a stall), or buffeting. In some cases, tufts will actually point forward, indicating the airflow has reversed direction.

Phosphatidylserine translocation to the mitochondrion is an ATP-dependent process in permeabilized animal cells

DOE Office of Scientific and Technical Information (OSTI.GOV)

Voelker, D.R.

1989-12-01

Chinese hamster ovary (CHO-K1) cells were pulse labeled with ({sup 3}H)serine, and the synthesis of phosphatidyl({sup 3}H)ethanolamine from phosphatidyl({sup 3}H)serine during the subsequent chase was used as a measure of lipid translocation to the mitochondria. When the CHO-K1 cells were pulse labeled and subsequently permeabilized with 50 {mu}g of saponin per ml, there was no significant turnover of nascent phosphatidyl({sup 3}H)serine to form phosphatidyl({sup 3}H)ethanolamine during an ensuring chase. Supplementation of the permeabilized cells with 2 mM ATP resulted in significant phosphatidyl({sup 3}H)ethanolamine synthesis (83% of that found in intact cells) from phosphatidyl({sup 3}H)serine during a subsequent 2-hr chase. Phosphatidyl({supmore » 3}H)ethanolamine synthesis essentially ceased after 2 hr in the permeabilized cells. The translocation-dependent synthesis of phosphatidyl({sup 3}H)ethanolamine was a saturable process with respect to ATP concentration in permeabilized cells. The conversion of phosphatidyl({sup 3}H)serine to phosphatidyl({sup 3}H)ethanolamine did not occur in saponin-treated cultures supplemented with 2 mM AMP, 2 mM 5{prime}-adenylyl imidodiphosphate, or apyrase plus 2 mM ATP. ATP was the most effective nucleotide, but the addition of GTP, CTP, UTP, and ADP also supported the translocation-dependent synthesis of phosphatidyl({sup 3}H)ethanolamine albeit to a lesser extent. These data provide evidence that the interorganelle translocation of phosphatidylserine requires ATP and is largely independent of soluble cytosolic proteins.« less

Spatial distribution and cellular composition of adult brain proliferative zones in the teleost, Gymnotus omarorum

PubMed Central

Olivera-Pasilio, Valentina; Peterson, Daniel A.; Castelló, María E.

2014-01-01

Proliferation of stem/progenitor cells during development provides for the generation of mature cell types in the CNS. While adult brain proliferation is highly restricted in the mammals, it is widespread in teleosts. The extent of adult neural proliferation in the weakly electric fish, Gymnotus omarorum has not yet been described. To address this, we used double thymidine analog pulse-chase labeling of proliferating cells to identify brain proliferation zones, characterize their cellular composition, and analyze the fate of newborn cells in adult G. omarorum. Short thymidine analog chase periods revealed the ubiquitous distribution of adult brain proliferation, similar to other teleosts, particularly Apteronotus leptorhynchus. Proliferating cells were abundant at the ventricular-subventricular lining of the ventricular-cisternal system, adjacent to the telencephalic subpallium, the diencephalic preoptic region and hypothalamus, and the mesencephalic tectum opticum and torus semicircularis. Extraventricular proliferation zones, located distant from the ventricular-cisternal system surface, were found in all divisions of the rombencephalic cerebellum. We also report a new adult proliferation zone at the caudal-lateral border of the electrosensory lateral line lobe. All proliferation zones showed a heterogeneous cellular composition. The use of short (24 h) and long (30 day) chase periods revealed abundant fast cycling cells (potentially intermediate amplifiers), sparse slow cycling (potentially stem) cells, cells that appear to have entered a quiescent state, and cells that might correspond to migrating newborn neural cells. Their abundance and migration distance differed among proliferation zones: greater numbers and longer range and/or pace of migrating cells were associated with subpallial and cerebellar proliferation zones. PMID:25249943

76 FR 58805 - Notice of Availability of Environmental Assessment; Jonathan and Jayne Chase

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-22

... hydropower project exemption for the Troy Hydroelectric Project, to be located on the Missisquoi River, in the Town of Troy in Orleans County, Vermont, and has prepared an Environmental Assessment (EA). In the...

4. Northeast side of Building 1009, (enlisted waves' barracks), looking ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. Northeast side of Building 1009, (enlisted waves' barracks), looking southwest - Naval Air Station Chase Field, Building 1009, Essex Street, .68 mile South-southeast of intersection of Texas State Highway 202 & Independence Street, Beeville, Bee County, TX

1. Overview of Building 1009, (enlisted waves' barracks), looking east ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. Overview of Building 1009, (enlisted waves' barracks), looking east - Naval Air Station Chase Field, Building 1009, Essex Street, .68 mile South-southeast of intersection of Texas State Highway 202 & Independence Street, Beeville, Bee County, TX

2. Southwest side of Building 1009, (enlisted waves' barracks), looking ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. Southwest side of Building 1009, (enlisted waves' barracks), looking northeast - Naval Air Station Chase Field, Building 1009, Essex Street, .68 mile South-southeast of intersection of Texas State Highway 202 & Independence Street, Beeville, Bee County, TX

3. Southwest side of quarters R (commanding officer's quarters), looking ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

3. Southwest side of quarters R (commanding officer's quarters), looking east - Naval Air Station Chase Field, Quarters R, Essex Street, .43 mile South-Southeast of intersection of Texas State Highway 202 & Independence Street, Beeville, Bee County, TX

3. Northwest side of Building 1009, (enlisted waves' barracks), looking ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

3. Northwest side of Building 1009, (enlisted waves' barracks), looking southeast - Naval Air Station Chase Field, Building 1009, Essex Street, .68 mile South-southeast of intersection of Texas State Highway 202 & Independence Street, Beeville, Bee County, TX

4. Northeast side of Building 1015 (land plane hangar), looking ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. Northeast side of Building 1015 (land plane hangar), looking southwest - Naval Air Station Chase Field, Building 1015, Byrd Street, .82 mile South-southeast of intersection of Texas State Highway 202 & Independence Street, Beeville, Bee County, TX

5. Southeast side of Building 1015 (land plane hangar), looking ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

5. Southeast side of Building 1015 (land plane hangar), looking northwest - Naval Air Station Chase Field, Building 1015, Byrd Street, .82 mile South-southeast of intersection of Texas State Highway 202 & Independence Street, Beeville, Bee County, TX

3. Northwest side of Building 1015 (land plane hangar), looking ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

3. Northwest side of Building 1015 (land plane hangar), looking east - Naval Air Station Chase Field, Building 1015, Byrd Street, .82 mile South-southeast of intersection of Texas State Highway 202 & Independence Street, Beeville, Bee County, TX

6. Interior of quarters (executive officer's quarters), living room, looking ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

6. Interior of quarters (executive officer's quarters), living room, looking west - Naval Air Station Chase Field, Quarters S, Essex Street, .45 mile South-Southeast of intersection of Texas State Highway 202 & Independence Street, Beeville, Bee County, TX

9. Interior of Building 1001 (administration building), Room 204, vault, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

9. Interior of Building 1001 (administration building), Room 204, vault, looking east - Naval Air Station Chase Field, Building 1001, Independence Street, .45 mile south of intersection of Texas State Highway & Independence Street, Beeville, Bee County, TX

1. North side of quarters (executive officer's quarters), looking southeast ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. North side of quarters (executive officer's quarters), looking southeast - Naval Air Station Chase Field, Quarters S, Essex Street, .45 mile South-Southeast of intersection of Texas State Highway 202 & Independence Street, Beeville, Bee County, TX

6. Detail of southeast side of Building 1040 (chapel), looking ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

6. Detail of southeast side of Building 1040 (chapel), looking northwest - Naval Air Station Chase Field, Building 1040, Enterprise Street, .37 mile South-Southeast of intersection of Texas State Highway 202 & Independence Street, Beeville, Bee County, TX

6. Overview of Building 1009, (enlisted waves' barracks), looking east ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

6. Overview of Building 1009, (enlisted waves' barracks), looking east - Naval Air Station Chase Field, Building 1009, Essex Street, .68 mile South-southeast of intersection of Texas State Highway 202 & Independence Street, Beeville, Bee County, TX

9. Interior of Building 1009, view of central hall, looking ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

9. Interior of Building 1009, view of central hall, looking southeast - Naval Air Station Chase Field, Building 1009, Essex Street, .68 mile South-southeast of intersection of Texas State Highway 202 & Independence Street, Beeville, Bee County, TX

2. Southwest side of Building 1015 (land plane hangar), looking ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. Southwest side of Building 1015 (land plane hangar), looking northeast - Naval Air Station Chase Field, Building 1015, Byrd Street, .82 mile South-southeast of intersection of Texas State Highway 202 & Independence Street, Beeville, Bee County, TX

5. East side of quarters (executive officer's quarters), looking west ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

5. East side of quarters (executive officer's quarters), looking west - Naval Air Station Chase Field, Quarters S, Essex Street, .45 mile South-Southeast of intersection of Texas State Highway 202 & Independence Street, Beeville, Bee County, TX

1. Northeast side of Quarters R (commanding officer's quarters), looking ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. Northeast side of Quarters R (commanding officer's quarters), looking west - Naval Air Station Chase Field, Quarters R, Essex Street, .43 mile South-Southeast of intersection of Texas State Highway 202 & Independence Street, Beeville, Bee County, TX

2. West side of quarters (executive officer's quarters), looking east ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. West side of quarters (executive officer's quarters), looking east - Naval Air Station Chase Field, Quarters S, Essex Street, .45 mile South-Southeast of intersection of Texas State Highway 202 & Independence Street, Beeville, Bee County, TX

2. Southeast side of Quarters R (commanding officer's quarters), looking ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. Southeast side of Quarters R (commanding officer's quarters), looking northwest - Naval Air Station Chase Field, Quarters R, Essex Street, .43 mile South-Southeast of intersection of Texas State Highway 202 & Independence Street, Beeville, Bee County, TX

4. Northwest side of Quarters R (commanding officer's quarters), looking ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. Northwest side of Quarters R (commanding officer's quarters), looking southeast - Naval Air Station Chase Field, Quarters R, Essex Street, .43 mile South-Southeast of intersection of Texas State Highway 202 & Independence Street, Beeville, Bee County, TX

7. Detail of southwest side of Building 1040 (gym), looking ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

7. Detail of southwest side of Building 1040 (gym), looking northeast - Naval Air Station Chase Field, Building 1040, Enterprise Street, .37 mile South-Southeast of intersection of Texas State Highway 202 & Independence Street, Beeville, Bee County, TX

6. Interior of Building 1015 (land plane hangar), looking north ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

6. Interior of Building 1015 (land plane hangar), looking north - Naval Air Station Chase Field, Building 1015, Byrd Street, .82 mile South-southeast of intersection of Texas State Highway 202 & Independence Street, Beeville, Bee County, TX

1. Overview of Building 1015 (land plane hanger), looking east ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. Overview of Building 1015 (land plane hanger), looking east - Naval Air Station Chase Field, Building 1015, Byrd Street, .82 mile South-southeast of intersection of Texas State Highway 202 & Independence Street, Beeville, Bee County, TX

4. South side of quarters (executive officer's quarters), looking north ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. South side of quarters (executive officer's quarters), looking north - Naval Air Station Chase Field, Quarters S, Essex Street, .45 mile South-Southeast of intersection of Texas State Highway 202 & Independence Street, Beeville, Bee County, TX

1. Overview of Building 1040 (auditorium/gym/chapel), looking north Naval ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. Overview of Building 1040 (auditorium/gym/chapel), looking north - Naval Air Station Chase Field, Building 1040, Enterprise Street, .37 mile South-Southeast of intersection of Texas State Highway 202 & Independence Street, Beeville, Bee County, TX

5. Southeast side of Building 1009, (enlisted waves' barracks), looking ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

5. Southeast side of Building 1009, (enlisted waves' barracks), looking west - Naval Air Station Chase Field, Building 1009, Essex Street, .68 mile South-southeast of intersection of Texas State Highway 202 & Independence Street, Beeville, Bee County, TX

3. Southwest side of quarters (executive officer's quarters), looking northeast ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

3. Southwest side of quarters (executive officer's quarters), looking northeast - Naval Air Station Chase Field, Quarters S, Essex Street, .45 mile South-Southeast of intersection of Texas State Highway 202 & Independence Street, Beeville, Bee County, TX

Tribological study of non-asbestos fiber reinforced phenolic composites for braking applications

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gopal, P.; Dharani, L.R.; Blum, F.D.

A cashew modified phenolic resin was used as the binder to prepare several different nonasbestos fiber reinforced composite friction materials. Friction-wear tests were conducted at various loads, speeds and temperatures on a Chase friction testing machine. The fade and wear characteristics of glass and carbon fiber reinforced friction materials were studied. The wear rates of hybrid composites containing Kevlar{reg_sign} (registered trademark of E.I. duPont de Nemours) pulp were compared to those of control composites without Kevlar{reg_sign} pulp.

Can dryland geoproxy data generate Quaternary palaeoclimate and palaeoenvironmental records?

NASA Astrophysics Data System (ADS)

Thomas, David S. G.

2017-04-01

Dryland regions present many challenges for robustly reconstructing late Quaternary palaeoenvironments and palaeoclimates, not least a common deficit, or considerable spatial variability, in the availability of high resolution biological proxy data sources. Substantial advances have been made in some regions in recent years, through the exploitation of new high resolution biomarker and isotope records, for example from hyrax middens (e.g. Chase et al., 2012) and from offshore sediments (e.g. Collins et al., 2014). In others however, suitable data sources for these approaches are absent, so these approaches are not available or if data are applied from distant sources, subject to risks of excessive spatial extrapolation of records in environmental contexts where environmental gradients are steep and variability is common (Thomas and Burrough, 2012, Thomas et al., 2013). In these contexts, geoproxy records, derived from the analysis of landforms and their associated sediments, are often utilised in dryland Quaternary research (e.g. Burrough and Thomas 2009, Stone and Thomas, 2013, Thomas, 2013, Lancaster et al., 2015), but with a number of associated difficulties (e.g. Chase, 2009). This paper examines these difficulties and then explores different approaches to the analysis of Quaternary landform records. It is argued that geoproxies with chronometric control, usually provided by OSL dating, have considerable potential to improve data on Quaternary environmental and climate dynamics, if records are interpreted effectively and appropriately (e.g. Bailey and Thomas, 2014, Thomas and Burrough, 2016). Examples of challenges and new approaches will be drawn from aeolian and fluvial domains, and from research in Africa, Australia and Arabia. Bailey RM, Thomas DSG 2014 Earth Surf. Proc. Landf. 39, 614-631. Burrough SL, Thomas DSG 2009. Geomorphology 103, 285-298. Chase, B 2009. Earth-Sci Rev. 93, 31-45. Chase BM et al. 2010 Quat. Sci. Rev. 56, 107-125. Collins JA et al. 2014 Earth Planet. Sci. Let. 398, 1-10. Lancaster N et al. 2016 Quat. Int. 410, 3-10. Stone AEC, Thomas DSG 2013 J. Arid Env. 93, 40-58. Thomas DSG 2013 Earth Surf. Proc. Landf. 38, 3-16. Thomas DSG, Burrough SL 2012 Quat. Int. 253, 5-17. Thomas DSG et al. 2012 J. Quat. Sci. 27, 7-12. Thomas DSG, Burrough SL 2016 Quat. Int. 410, 30-45.

Biogenesis of the rat hepatocyte plasma membrane in vivo: comparison of the pathways taken by apical and basolateral proteins using subcellular fractionation

PubMed Central

1987-01-01

We have used pulse-chase metabolic radiolabeling with L-[35S]methionine in conjunction with subcellular fractionation and specific protein immunoprecipitation techniques to compare the posttranslational transport pathways taken by endogenous domain-specific integral proteins of the rat hepatocyte plasma membrane in vivo. Our results suggest that both apical (HA 4, dipeptidylpeptidase IV, and aminopeptidase N) and basolateral (CE 9 and the asialoglycoprotein receptor [ASGP-R]) proteins reach the hepatocyte plasma membrane with similar kinetics. The mature molecular mass form of each of these proteins reaches its maximum specific radioactivity in a purified hepatocyte plasma membrane fraction after only 45 min of chase. However, at this time, the mature radiolabeled apical proteins are not associated with vesicles derived from the apical domain of the hepatocyte plasma membrane, but instead are associated with vesicles which, by several criteria, appear to be basolateral plasma membrane. These vesicles: (a) fractionate like basolateral plasma membrane in sucrose density gradients and in free-flow electrophoresis; (b) can be separated from the bulk of the likely organellar contaminants, including membranes derived from the late Golgi cisternae, transtubular network, and endosomes; (c) contain the proven basolateral constituents CE 9 and the ASGP-R, as judged by vesicle immunoadsorption using fixed Staphylococcus aureus cells and anti-ASGP-R antibodies; and (d) are oriented with their ectoplasmic surfaces facing outward, based on the results of vesicle immunoadsorption experiments using antibodies specific for the ectoplasmic domain of the ASGP-R. Only at times of chase greater than 45 min do significant amounts of the mature radiolabeled apical proteins arrive at the apical domain, and they do so at different rates. Approximate half-times for arrival are in the range of 90-120 min for aminopeptidase N and dipeptidylpeptidase IV whereas only 15-20% of the mature radiolabeled HA 4 associated with the hepatocyte plasma membrane fraction has become apical even after 150 min of chase. Our results suggest a mechanism for hepatocyte plasma membrane biogenesis in vivo in which all integral plasma membrane proteins are shipped first to the basolateral domain, followed by the specific retrieval and transport of apical proteins to the apical domain at distinct rates. PMID:3654750

A structural and kinetic study on myofibrils prevented from shortening by chemical cross-linking.

PubMed

Herrmann, C; Sleep, J; Chaussepied, P; Travers, F; Barman, T

1993-07-20

In previous work, we studied the early steps of the Mg(2+)-ATPase activity of Ca(2+)-activated myofibrils [Houadjeto, M., Travers, F., & Barman, T. (1992) Biochemistry 31, 1564-1569]. The myofibrils were free to contract, and the results obtained refer to the ATPase cycle of myofibrils contracting with no external load. Here we studied the ATPase of myofibrils contracting isometrically. To prevent shortening, we cross-linked them with 1-ethyl-3-[3-(dimethylamino)propyl]carbodiimide (EDC). SDS-PAGE and Western blot analyses showed that the myosin rods were extensively cross-linked and that 8% of the myosin heads were cross-linked to the thin filament. The transient kinetics of the cross-linked myofibrils were studied in 0.1 M potassium acetate, pH 7.4 and 4 degrees C, by the rapid-flow quench method. The ATP binding steps were studied by the cold ATP chase and the cleavage and release of products steps by the Pi burst method. In Pi burst experiments, the sizes of the bursts were equal within experimental error to the ATPase site concentrations (as determined by the cold ATP chase methods) for both cross-linked (isometric) and un-cross-linked (isotonic) myofibrils. This shows that in both cases the rate-limiting step is after the cleavage of ATP. When cross-linked, the kcat of Ca(2+)-activated myofibrils was reduced from 1.7 to 0.8 s-1. This is consistent with the observation that fibers shortening at moderate velocity have a higher ATPase activity than isometric fibers.(ABSTRACT TRUNCATED AT 250 WORDS)

SmartSearch steganalysis

NASA Astrophysics Data System (ADS)

Bloom, Jeffrey A.; Alonso, Rafael

2003-06-01

There are two primary challenges to monitoring the Web for steganographic media: finding suspect media and examining those found. The challenge that has received a great deal of attention is the second of these, the steganalysis problem. The other challenge, and one that has received much less attention, is the search problem. How does the steganalyzer get the suspect media in the first place? This paper describes an innovative method and architecture to address this search problem. The typical approaches to searching the web for covert communications are often based on the concept of "crawling" the Web via a smart "spider." Such spiders find new pages by following ever-expanding chains of links from one page to many next pages. Rather than seek pages by chasing links from other pages, we find candidate pages by identifying requests to access pages. To do this we monitor traffic on Internet backbones, identify and log HTTP requests, and use this information to guide our process. Our approach has the advantages that we examine pages to which no links exist, we examine pages as soon as they are requested, and we concentrate resources only on active pages, rather than examining pages that are never viewed.

7. Interior of Building 1015 (land plane hangar), structural detail, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

7. Interior of Building 1015 (land plane hangar), structural detail, looking northeast - Naval Air Station Chase Field, Building 1015, Byrd Street, .82 mile South-southeast of intersection of Texas State Highway 202 & Independence Street, Beeville, Bee County, TX

2. Southeast side of Building 1040 (auditorium/gym/chapel), looking northwest ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. Southeast side of Building 1040 (auditorium/gym/chapel), looking northwest - Naval Air Station Chase Field, Building 1040, Enterprise Street, .37 mile South-Southeast of intersection of Texas State Highway 202 & Independence Street, Beeville, Bee County, TX

7. Staircase on south side of Building 1009, (enlisted waves' ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

7. Staircase on south side of Building 1009, (enlisted waves' barracks), looking southeast - Naval Air Station Chase Field, Building 1009, Essex Street, .68 mile South-southeast of intersection of Texas State Highway 202 & Independence Street, Beeville, Bee County, TX

8. Interior of Building 1015 (land plane hangar), structural detail, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

8. Interior of Building 1015 (land plane hangar), structural detail, looking northeast - Naval Air Station Chase Field, Building 1015, Byrd Street, .82 mile South-southeast of intersection of Texas State Highway 202 & Independence Street, Beeville, Bee County, TX

5. Interior of Quarters R (commanding officer's quarters), living room, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

5. Interior of Quarters R (commanding officer's quarters), living room, looking northwest - Naval Air Station Chase Field, Quarters R, Essex Street, .43 mile South-Southeast of intersection of Texas State Highway 202 & Independence Street, Beeville, Bee County, TX

3. Southeast side of Building 1040 (auditorium/gym/chapel), looking northwest ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

3. Southeast side of Building 1040 (auditorium/gym/chapel), looking northwest - Naval Air Station Chase Field, Building 1040, Enterprise Street, .37 mile South-Southeast of intersection of Texas State Highway 202 & Independence Street, Beeville, Bee County, TX

4. Northeast side of Building 1040 (auditorium/gym/chapel), looking southwest ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. Northeast side of Building 1040 (auditorium/gym/chapel), looking southwest - Naval Air Station Chase Field, Building 1040, Enterprise Street, .37 mile South-Southeast of intersection of Texas State Highway 202 & Independence Street, Beeville, Bee County, TX

5. Northwest side of Building 1040 (auditorium/gym/chapel), looking south ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

5. Northwest side of Building 1040 (auditorium/gym/chapel), looking south - Naval Air Station Chase Field, Building 1040, Enterprise Street, .37 mile South-Southeast of intersection of Texas State Highway 202 & Independence Street, Beeville, Bee County, TX

78 FR 1853 - EH California Hydro, LLC; Notice of Preliminary Permit Application Accepted for Filing and...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-09

... tailrace. Applicant Contact: Mr. John R. Collins, EH California Hydro, LLC, 5425 Wisconsin Avenue, Suite 600, Chevy Chase, Maryland 20815; phone: (301) 718-4433. FERC Contact: Jim Fargo at [email protected

RESTORING WILD SALMON TO THE PACIFIC NORTHWEST: CHASING AN ILLUSION

EPA Science Inventory

Throughout the Pacific Northwest (northern California, Oregon, Idaho, Washington, and the Columbia Basin portion of British Columbia), many wild salmon "stocks" (a group of interbreeding individuals that is roughly equivalent to a "population") have declined and some have been ...

50 CFR 226.217 - Critical habitat for the Gulf of Maine Distinct Population Segment of Atlantic Salmon (Salmo salar).

Code of Federal Regulations, 2010 CFR

2010-10-01

..., Herseytown Plt, Kingman Twp, Lee, Lincoln, Mattawamkeag, Mount Chase, Patten, Prentiss Twp T7 R3 NBPP..., Hudson, Indian Island, Kenduskeag, Lagrange, Lakeville, Lee, Levant, Lincoln, Lowell, Mattamiscontis Twp...

50 CFR 226.217 - Critical habitat for the Gulf of Maine Distinct Population Segment of Atlantic Salmon (Salmo salar).

Code of Federal Regulations, 2011 CFR

2011-10-01

..., Herseytown Plt, Kingman Twp, Lee, Lincoln, Mattawamkeag, Mount Chase, Patten, Prentiss Twp T7 R3 NBPP..., Hudson, Indian Island, Kenduskeag, Lagrange, Lakeville, Lee, Levant, Lincoln, Lowell, Mattamiscontis Twp...

UAS Research - Who's Doing What?

NASA Technical Reports Server (NTRS)

Hackenberg, Davis

2018-01-01

This presentation includes the UAS-Enabled Market Categories used in Study, as well as the reason for the UAS-NAS NO Chase COA flight. It discusses the transitioning of a UA from different airspaces. UAS Integration is a community wide effort, and the FAA Symposium provides attendees with the opportunity to engage face-to-face with a cross-section of government and industry leaders and innovators about the latest industry developments, regulations, research, and other initiatives to safely integrate UAS into the National Airspace System (NAS).

Establishment of the Fox Chase Network Breast Cancer Risk Registry.

DTIC Science & Technology

1995-10-01

Howe, G.R., Hirohata, T., Hislop , T.G., et al. "Dietary factors and risk of breast cancer: Combined analysis of 12 case-control studies," J Natl...1993. 15. King MC, Rowell S, Love SM: Inherited breast and ovarian cancer. What are the risks? What are the choices? JAMA 269(15):1975- 1980 , 1993. 16...3):118-124, 1980 . Kelly, Patricia T. Dealing with Dilemma. A Manual for Genetic Counselors. Springer-Verlag, New York, NY pp. 1-143, 1977. Kelly

Empirical Assessment of Lanius et al.s’ ’Functional MRI of EMDR in Peacekeepers’, a Review of the EMDR Literature and an annotated bibliography

DTIC Science & Technology

2002-07-01

placebo control conditions. Journal of Consulting and Clinical Psychology , 68, 947-956. Herbert, J.D., Lilienfeld , S.O., Lorh, J.M., Montgomery, R.W...or to justify the time and psychological commitment of CF personnel suffering from PTSD. The major objective of the proposed study, then, is to assess...Carrigan, & Freuh, 1999; Davidson & Parker, 2001; Herbert, Lilienfeld , Lorh, Montgomery, O’Donohue, Rosen, & Tolin, 2000; Hudson, Chase, & Pope, 1998

Responding to Challenges and Conflict in Higher Education Collective Bargaining. Proceeding of the Annual Conference of the National Center for the Study of Collective Bargaining in Higher Education and the Professions (26th, April 1998).

ERIC Educational Resources Information Center

Naples, Caesar J., Ed.

This proceedings presents 18 essays that focus on collective bargaining and other labor issues in higher education. The essays include: (1) "Looking Toward the Future" (Sandra Feldman); (2) "The New Unionism in Higher Education" (Bob Chase); (3) "Post-Tenure Review: Threat or Promise" (Christine M. Licata); (4) "A Response to Post-Tenure Review:…

Electronic gaming machines and gambling disorder: a cross-cultural comparison between Brazil and the United States

PubMed Central

Medeiros, Gustavo Costa; Leppink, Eric W.; Yaemi, Ana; Mariani, Mirella; Tavares, Hermano; Grant, Jon E.

2015-01-01

Aims The objective of this paper is to perform a cross-cultural comparison of gambling disorder (GD) due to electronic gaming machines (EGM), a form of gambling that may have a high addictive potential. Our goal is to investigate two treatment-seeking samples of adults collected in Brazil and the United States, countries with different socio-cultural backgrounds. This comparison may lead to a better understanding of cultural influences on GD. Methods The total studied sample involved 733 treatment-seeking subjects: 353 men and 380 women (average age = 45.80, standard deviation ±10.9). The Brazilian sample had 517 individuals and the American sample 216. Subjects were recruited by analogous strategies. Results We found that the Brazilian sample was younger, predominantly male, less likely to be Caucasian, more likely to be partnered, had a faster progression from recreational gambling to GD, and were more likely to endorse chasing losses. Conclusion This study demonstrated that there are significant differences between treatment-seeking samples of adults presenting GD due to EGM in Brazil and in the United States. These findings suggest that cultural aspects may have a relevant role in GD due to EGM. PMID:26474662

Cognitive distortions among older adult gamblers in an Asian context.

PubMed

Subramaniam, Mythily; Chong, Siow Ann; Browning, Colette; Thomas, Shane

2017-01-01

The study aims to describe the construct of cognitive distortions based on the narratives of older adult gamblers (aged 60 years and above) in Singapore. Singapore residents (citizens or permanent residents) aged 60 years and above, who were current or past regular gamblers were included in the study. Participants were recruited using a combination of venue based approach, referrals from service providers as well as by snowball sampling. In all, 25 in-depth interviews were conducted with older adult gamblers. The six-step thematic network analysis methodology was adopted for data analysis. The mean age of the participants was 66.2 years. The majority were male (n = 18), of Chinese ethnicity (n = 16), with a mean age of gambling initiation at 24.5 years. Among older adult gamblers, cognitive distortions emerged as a significant global theme comprising three organizing themes-illusion of control, probability control and interpretive control. The organizing themes comprised nine basic themes: perception of gambling as a skill, near miss, concept of luck, superstitious beliefs, entrapment, gambler's fallacy, chasing wins, chasing losses, and beliefs that wins are more than losses. Cognitive distortions were endorsed by all gamblers in the current study and were shown to play a role in both maintaining and escalating the gambling behaviour. While the surface characteristics of the distortions had a culture-specific appearance, the deeper characteristics of the distortions may in fact be more universal than previously thought. Future research must include longitudinal studies to understand causal relationships between cognitive distortions and gambling as well as the role of culture-specific distortions both in the maintenance and treatment of the disorder.

Effects of a ketogenic diet on ADHD-like behavior in dogs with idiopathic epilepsy.

PubMed

Packer, Rowena M A; Law, Tsz Hong; Davies, Emma; Zanghi, Brian; Pan, Yuanlong; Volk, Holger A

2016-02-01

Epilepsy in humans and rodent models of epilepsy can be associated with behavioral comorbidities including an increased prevalence of attention-deficit/hyperactivity disorder (ADHD). Attention-deficit/hyperactivity disorder symptoms and seizure frequency have been successfully reduced in humans and rodents using a ketogenic diet (KD). The aims of this study were (i) to describe the behavioral profile of dogs with idiopathic epilepsy (IE) while on a standardized nonketogenic placebo diet, to determine whether ADHD-like behaviors are present, and (ii) to examine the effect of a ketogenic medium chain triglyceride diet (MCTD) on the behavioral profile of dogs with idiopathic epilepsy (IE) compared with the standardized placebo control diet, including ADHD-like behaviors. A 6-month prospective, randomized, double-blinded, placebo-controlled, crossover dietary trial comparing the effects of the MCTD with a standardized placebo diet on canine behavior was carried out. Dogs diagnosed with IE, with a seizure frequency of at least 3 seizures in the past 3months (n=21), were fed the MCTD or placebo diet for 3months and were then switched to the alternative diet for 3months. Owners completed a validated behavioral questionnaire to measure 11 defined behavioral factors at the end of each diet period to report their dogs' behavior, with three specific behaviors hypothesized to be related to ADHD: excitability, chasing, and trainability. The highest scoring behavioral factors in the placebo and MCTD periods were excitability (mean±SE: 1.910±0.127) and chasing (mean±SE: 1.824±0.210). A markedly lower trainability score (mean±SE: 0.437±0.125) than that of previously studied canine populations was observed. The MCTD resulted in a significant improvement in the ADHD-related behavioral factor chasing and a reduction in stranger-directed fear (p<0.05) compared with the placebo diet. The latter effect may be attributed to previously described anxiolytic effects of a KD. These data support the supposition that dogs with IE may exhibit behaviors that resemble ADHD symptoms seen in humans and rodent models of epilepsy and that a MCTD may be able to improve some of these behaviors, along with potentially anxiolytic effects. Copyright © 2015 Elsevier Inc. All rights reserved.

Effects of chronic metal exposure and sediment organic matter on digestive absorption efficiency of cadmium by the deposit-feeding polychaete Capitella species I

DOE Office of Scientific and Technical Information (OSTI.GOV)

Selck, H.; Forbes, V.E.; Decho, A.W.

1999-06-01

Organic matter such as humic acid and bacterial slime exopolymer are common in estuarine and coastal sediments, where they are ingested by animals that process particulate detritus. Both humic acid (HA; refractory) and exopolymer (EPS; easily digestible) bind metals and therefore might represent a source of particulate-bound metals to deposit-feeding organisms. This study examined how cadmium preexposure, gut passage time (GPT), and quality and quantity of the organic coating on sediment particles interact to determine cadmium absorption efficiency (Cd-AE) in Capitella sp. I. Pulse-chase experiments using [sup 109]Cd and [sup 51]Cr were used to determine Cd-AE in individual worms. Wormsmore » were given a pulse of carbon-cleaned, HA-coated or EPS-coated sediment particles. The third treatment was divided into three EPS concentrations (high, medium, and low). A 5-d preexposure to cadmium did not affect the egestion rates during either the preexposure period or the chase phase. Worms given a pulse of carbon-cleaned particles exhibited higher egestion rates during the chase phase than worms given a pulse of organic-coated particles, and no differences were seen in egestion rate between worms exposed to HA- and high-EPS-coated particles. Egestion rates decreased with increasing EPS concentration. The presence of refractory organic material decreased the absorption efficiency of cadmium from sediment relative to Cd-AE from carbon-cleaned sediment but not relative to Cd-AE from sediment coated with a high concentration of EPS. The Cd-AE increased linearly with increasing exopolymer coating on sediment particles. Overall, Cd-AE increased with increasing gut passage time in worms that were not preexposed, although Cd-AE from HA-coated particles was independent of gut passage time. Preexposure to cadmium reversed the relationship between gut passage time and cadmium absorption efficiency. Thus, the implications are that sedimentary organic matter and worm physiology might be especially important in controlling metal bioavailability in deposit-feeding organisms and should be considered in sediment quality approaches.« less

Black Newspapers: Neglected Source for the "New South."

ERIC Educational Resources Information Center

Beatty, Bess

1980-01-01

Examines the political climate and popular Black opinion in the late nineteenth century South through the writings of six Black southern newspaper editors (Pinckney Benton Stewart Pinchback, Charles Hendley, W. Calvin Chase, John Mitchell, Jr., William Pledger, and John Willis Menard). (GC)

Fort Douglas, Stilwell Field, The portion of Fort Douglas bounded ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Fort Douglas, Stilwell Field, The portion of Fort Douglas bounded by De Trobriand Street on the north, Fort Douglas Boulevard on the east, Potter Street on the south, and Chase Street on the west. , Salt Lake City, Salt Lake County, UT

Fiscal Year 2007 House Budget Hearing

NASA Image and Video Library

2006-02-16

NASA Administrator Michael Griffin, right, and Brian Chase, NASA's Assistant Administrator for Legislative Affairs confer prior to the start of a hearing before the House Science & Technology Committee regarding NASA's FY 2007 budget request, Thursday, Feb., 16, 2006, in Washington. Photo Credit: (NASA/Bill Ingalls)

75 FR 51849 - Investigations Regarding Certifications of Eligibility To Apply for Worker Adjustment Assistance

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-23

... Kimble Chase Life Science Vineland, NJ 08/04/10 07/14/10 and Research Products, LLC (Company). 74464.../10 74488 Computer Sciences Newark, DE 08/06/10 07/30/10 Corporation (CSC) (State/ One-Stop). 74489...

RESTORING WILD SALMON TO THE PACIFIC NORTHWEST: CHASING AN ILLUSION?

EPA Science Inventory

Throughout the Pacific Northwest (northern California, Oregon, Idaho, Washington, and the Columbia Basin portion of British Columbia), many wild salmon "stocks" (a group of interbreeding individuals that is roughly equivalent to a "population) have declined and some have been e...

Intracellular accumulation and oligosaccharide processing of alkaline phosphatase under disassembly of the Golgi complex caused by brefeldin A.

PubMed

Takami, N; Oda, K; Fujiwara, T; Ikehara, Y

1990-12-27

Electron microscopic observations showed that the fungal metabolite brefeldin A caused disassembly of the Golgi complex in human choriocarcinoma cells and accumulation of alkaline phosphatase (ALP) in the endoplasmic reticulum (ER) and nuclear envelope, where ALP was not apparently detectable in control cells. Pulse/chase experiments with [35S]methionine demonstrated that in the control cells, ALP synthesized as a 63-kDa precursor form was rapidly converted to a 66-kDa form, by processing of its N-linked oligosaccharides from the high-mannose type to the complex type, which was expressed on the cell surface after 30 min of chase. In contrast, in the brefeldin-A-treated cells the precursor was gradually converted to a 65-kDa form, slightly smaller than the control mature form, which was not expressed on the cell surface even after a prolonged time of chase. Kinetics of the ALP processing in the brefeldin-A-treated cells demonstrated that the precursor was initially converted to an intermediate form, partially sensitive to endo-beta-N-acetylglucosaminidase H (endo H), then to an endo-H-resistant 65-kDa form. In addition, this form was found to be sensitive to neuraminidase digestion, though its sialylation was not so complete as that of the control mature form. Taken together, these results suggest that under disassembly of the Golgi complex caused by brefeldin A, oligosaccharide-processing enzymes including sialyltransferase, an enzyme in the trans Golgi cisterna(e) and/or the trans Golgi network, might be redistributed into the ER and involved in processing of the oligosaccharides of ALP accumulating there.

N-terminal domains of fibrillin 1 and fibrillin 2 direct the formation of homodimers: a possible first step in microfibril assembly.

PubMed Central

Trask, T M; Ritty, T M; Broekelmann, T; Tisdale, C; Mecham, R P

1999-01-01

Aggregation of fibrillin molecules via disulphide bonds is postulated to be an early step in microfibril assembly. By expressing fragments of fibrillin 1 and fibrillin 2 in a mammalian expression system, we found that the N-terminal region of each protein directs the formation of homodimers and that disulphide bonds stabilize this interaction. A large fragment of fibrillin 1 containing much of the region downstream from the N-terminus remained as a monomer when expressed in the same cell system, indicating that this region of the protein lacks dimerization domains. This finding also confirms that the overexpression of fibrillin fragments does not in itself lead to spurious dimer formation. Pulse-chase analysis demonstrated that dimer formation occurred intracellularly, suggesting that the process of fibrillin aggregation is initiated early after biosynthesis of the molecules. These findings also implicate the N-terminal region of fibrillin 1 and fibrillin 2 in directing the formation of a dimer intermediate that aggregates to form the functional microfibril. PMID:10359653

Stroller running: Energetic and kinematic changes across pushing methods.

PubMed

Alcantara, Ryan S; Wall-Scheffler, Cara M

2017-01-01

Running with a stroller provides an opportunity for parents to exercise near their child and counteract health declines experienced during early parenthood. Understanding biomechanical and physiological changes that occur when stroller running is needed to evaluate its health impact, yet the effects of stroller running have not been clearly presented. Here, three commonly used stroller pushing methods were investigated to detect potential changes in energetic cost and lower-limb kinematics. Sixteen individuals (M/F: 10/6) ran at self-selected speeds for 800m under three stroller conditions (2-Hands, 1-Hand, and Push/Chase) and an independent running control. A significant decrease in speed (p = 0.001) and stride length (p<0.001) was observed between the control and stroller conditions, however no significant change in energetic cost (p = 0.080) or heart rate (p = 0.393) was observed. Additionally, pushing method had a significant effect on speed (p = 0.001) and stride length (p<0.001). These findings suggest that pushing technique influences stroller running speed and kinematics. These findings suggest specific fitness effects may be achieved through the implementation of different pushing methods.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dougan, A D; Trombino, D; Dunlop, W

The Naval Postgraduate School has been conducting Tactical Network Topology (TNT) Maritime Interdiction Operations (MIO) experiments with Lawrence Livermore National Laboratory (LLNL) since early in 2005. In this work, we are investigating cutting edge technology to evaluate use of networks, advanced sensors and collaborative technology for globally-supported maritime interdiction operations. Some examples of our research include communications in harsh environments, between moving ships at sea; small boat drive-by radiation detection; network-centric collaboration with global partners; situational awareness; prototype sensors & biometric instruments. Since 2006, we have studied the concept of using a small vessel with fixed radiation sensors to domore » initial searches for illicit radioactive materials. In our work, we continue to evaluate concepts of operation for small boat monitoring. For example, in San Francisco Bay we established a simulated choke point using two RHIBs. Each RHIB had a large sodium iodide radiation sensor on board, mounted on the side nearest to the passing potential target boats. Once detections were made, notification over the network prompted a chase RHIB also equipped with a radiation sensor to further investigate the potential target. We have also used an unmanned surface vessel (USV) carrying a radiation sensor to perform the initial discovery. The USV was controlled remotely and to drive by boats in different configurations. The potential target vessels were arranged in a line, as a choke point and randomly spaced in the water. Search plans were problematic when weather, waves and drift complicated the ability to stay in one place. A further challenge is to both detect and identify the radioactive materials during the drive-by. Our radiation detection system, ARAM, Adaptable Radiation Area Monitor, is able to detect, alarm and quickly identify plausible radionuclides in real time. We have performed a number of experiments to better understand parameters of vessel speed, time, shielding, and distance in this complex three-dimensional space. At the NMIOTC in September 2009, we employed a dual detector portal followed by a chase. In this event, the challenge was to maintain communications after a lapse. When the chase went past the line-of sight reach of the Tactical Operational Center's (TOC) antenna, with interference from a fortress island in Suda Bay, Wave Relay extended the network for continued observation. Sodium iodide radiation detectors were mounted on two Hellenic Navy SEAL fast boats. After making the detection one of the portal boats maintained line-of sight while the other pursued the target vessel. Network access via Wave Relay antennas was maintained until the conclusion of the chase scenario. Progress has been made in the detection of radioactive materials in the maritime environment. The progression of the TNT MIO experiments has demonstrated the potential of the hardware to solve the problems encountered in this physically challenging environment. There continue to be interesting opportunities for research and development. These experiments provide a variety of platforms and motivated participants to perform real-world testing as solutions are made available.« less

Eliminate the "Bounce"!

ERIC Educational Resources Information Center

Leigh, Susan

2016-01-01

The "bounce" (coined by students at Susan Leigh's last campus) refers to the amount of time students spent chasing signatures and removing often-unnecessary registration "holds" in order to attend their classes. Leigh explains that all this chaos from complex, separately housed transactional business processes has led to the…

Identifying Determinants of PARP Inhibitor Sensitivity in Ovarian Cancer

DTIC Science & Technology

2015-10-01

such as those lacking functional BRCA1 are highly sensitive to poly(ADP-ribose) polymerase (PARP) inhibitors. Ovarian cancer patients that harbored...Principal Investigator (Last, first, middle): Johnson, Neil  Dr. Johnson’s mentor, Dr. Jeffrey Boyd, left Fox Chase for Florida International

1. Overview of Independence Street, with Building 1001 (administration building) ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. Overview of Independence Street, with Building 1001 (administration building) on right, looking south - Naval Air Station Chase Field, Texas State Highway 202, 4.8 miles east of intersection of Texas State Highway 202 & U.S. State Highway 181, Beeville, Bee County, TX

Conway Morris: Extraterrestrials: Aliens like us?

NASA Astrophysics Data System (ADS)

Morris, Simon Conway

2005-08-01

So what are they going to be like, those long-expected extraterrestrials? Hideous hydrocarbon arachnoids, waving laser cannons as they chase screaming humans, repulsively surveying the scene through empathy-free compound eyes? Or maybe laughing bipeds, chatting away, holding a glass of wine, a bit like us?

75 FR 51832 - Kansas; Major Disaster and Related Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-23

... determinations. DATES: Effective Date: August 10, 2010. FOR FURTHER INFORMATION CONTACT: Peggy Miller, Recovery... Hazard Mitigation will be limited to 75 percent of the total eligible costs. Further, you are authorized... Atchison, Brown, Butler, Chase, Clay, Cloud, Comanche, Doniphan, Ellis, Franklin, Greenwood, Harvey, Jewell...

Biological Collections: Chasing the Ideal

PubMed Central

Kamenski, P. A.; Sazonov, A. E.; Fedyanin, A. A.; Sadovnichy, V. A.

2016-01-01

This article is based on the results of an analysis of existing biological collections in Russia and abroad set up in the framework of the project “Scientific Basis of the National Biobank –Depository of Living Systems” by M.V. Lomonosov Moscow State University [1]. PMID:27437135

17. INTERIOR VIEW INSIDE BUNKER. MAN SEATED AT LEFT LOOKS ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

17. INTERIOR VIEW INSIDE BUNKER. MAN SEATED AT LEFT LOOKS AT OPENING TO CABLE CHASE, HIS HANDS ON MANUALLY-OPERATED PULLEY. INEL PHOTO NUMBER 65-6179, TAKEN NOVEMBER 10, 1965. - Idaho National Engineering Laboratory, Advanced Reentry Vehicle Fusing System, Scoville, Butte County, ID

Chasing a Fault across Ship and Shore

ERIC Educational Resources Information Center

Evans, Michael A.; Schwen, Thomas M.

2006-01-01

Knowledge management (KM) in the U.S. Navy is championed as a strategic initiative to improve shipboard maintenance and troubleshooting at a distance. The approach requires capturing, coordinating, and distributing domain expertise in electronics and computer engineering via advanced information and communication technologies. Coordination must be…

3. VIEW OF ARVFS BUNKER TAKEN FROM APPROXIMATELY 150 FEET ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

3. VIEW OF ARVFS BUNKER TAKEN FROM APPROXIMATELY 150 FEET EAST OF BUNKER DOOR. CAMERA FACING WEST. VIEW SHOWS EARTH MOUND COVERING CONTROL BUNKER AND REMAINS OF CABLE CHASE. - Idaho National Engineering Laboratory, Advanced Reentry Vehicle Fusing System, Scoville, Butte County, ID

Infants' Perception of Chasing

ERIC Educational Resources Information Center

Frankenhuis, Willem E.; House, Bailey; Barrett, H. Clark; Johnson, Scott P.

2013-01-01

Two significant questions in cognitive and developmental science are first, whether objects and events are selected for attention based on their features (featural processing) or the configuration of their features (configural processing), and second, how these modes of processing develop. These questions have been addressed in part with…

NASA 947 and NASA 904 during training flight over White Sands, New Mexico

NASA Technical Reports Server (NTRS)

1982-01-01

NASA 947 and NASA 904 during a training and familiarization flight over White Sands, New Mexico. The Gulfstream aircraft on the left is NASA's Space Shuttle Training aircraft (STA) and the T-38 jet serves as a chase plane.

Additive opportunistic capture explains group hunting benefits in African wild dogs.

PubMed

Hubel, Tatjana Y; Myatt, Julia P; Jordan, Neil R; Dewhirst, Oliver P; McNutt, J Weldon; Wilson, Alan M

2016-03-29

African wild dogs (Lycaon pictus) are described as highly collaborative endurance pursuit hunters based on observations derived primarily from the grass plains of East Africa. However, the remaining population of this endangered species mainly occupies mixed woodland savannah where hunting strategies appear to differ from those previously described. We used high-resolution GPS and inertial technology to record fine-scale movement of all members of a single pack of six adult African wild dogs in northern Botswana. The dogs used multiple short-distance hunting attempts with a low individual kill rate (15.5%), but high group feeding rate due to the sharing of prey. Use of high-level cooperative chase strategies (coordination and collaboration) was not recorded. In the mixed woodland habitats typical of their current range, simultaneous, opportunistic, short-distance chasing by dogs pursuing multiple prey (rather than long collaborative pursuits of single prey by multiple individuals) could be the key to their relative success in these habitats.

Development of an autonomous video rendezvous and docking system, phase 2

NASA Technical Reports Server (NTRS)

Tietz, J. C.; Richardson, T. E.

1983-01-01

The critical elements of an autonomous video rendezvous and docking system were built and used successfully in a physical laboratory simulation. The laboratory system demonstrated that a small, inexpensive electronic package and a flight computer of modest size can analyze television images to derive guidance information for spacecraft. In the ultimate application, the system would use a docking aid consisting of three flashing lights mounted on a passive target spacecraft. Television imagery of the docking aid would be processed aboard an active chase vehicle to derive relative positions and attitudes of the two spacecraft. The demonstration system used scale models of the target spacecraft with working docking aids. A television camera mounted on a 6 degree of freedom (DOF) simulator provided imagery of the target to simulate observations from the chase vehicle. A hardware video processor extracted statistics from the imagery, from which a computer quickly computed position and attitude. Computer software known as a Kalman filter derived velocity information from position measurements.

Additive opportunistic capture explains group hunting benefits in African wild dogs

PubMed Central

Hubel, Tatjana Y.; Myatt, Julia P.; Jordan, Neil R.; Dewhirst, Oliver P.; McNutt, J. Weldon; Wilson, Alan M.

2016-01-01

African wild dogs (Lycaon pictus) are described as highly collaborative endurance pursuit hunters based on observations derived primarily from the grass plains of East Africa. However, the remaining population of this endangered species mainly occupies mixed woodland savannah where hunting strategies appear to differ from those previously described. We used high-resolution GPS and inertial technology to record fine-scale movement of all members of a single pack of six adult African wild dogs in northern Botswana. The dogs used multiple short-distance hunting attempts with a low individual kill rate (15.5%), but high group feeding rate due to the sharing of prey. Use of high-level cooperative chase strategies (coordination and collaboration) was not recorded. In the mixed woodland habitats typical of their current range, simultaneous, opportunistic, short-distance chasing by dogs pursuing multiple prey (rather than long collaborative pursuits of single prey by multiple individuals) could be the key to their relative success in these habitats. PMID:27023355

Label-Retaining Stromal Cells in Mouse Endometrium Awaken for Expansion and Repair After Parturition

PubMed Central

Cao, Mingzhu; Yeung, William S.B.

2015-01-01

Human and mouse endometrium undergo dramatic cellular reorganization during pregnancy and postpartum. Somatic stem cells maintain homeostasis of the tissue by providing a cell reservoir for regeneration. We hypothesized that endometrial cells with quiescent properties (stem/progenitor cells) were involved in the regeneration of the endometrial tissue. Given that stem cells divide infrequently, they can retain the DNA synthesis label [bromodeoxyuridine (BrdU)] after a prolonged chase period. In this study, prepubertal mice were pulsed with BrdU and after a 6-week chase a small population of label-retaining stromal cells (LRSC) was located primarily beneath the luminal epithelium, adjacent to blood vessels, and near the endometrial–myometrial junction. Marker analyses suggested that they were of mesenchymal origin expressing CD44+, CD90+, CD140b+, CD146+, and Sca-1+. During pregnancy, nonproliferating LRSC predominately resided at the interimplantation/placental loci of the gestational endometrium. Immediately after parturition, a significant portion of the LRSC underwent proliferation (BrdU+/Ki-67+) and expressed total and active β-catenin. The β-catenin expression in the LRSC was transiently elevated at postpartum day (PPD) 1. The proliferation of LRSC resulted in a significant decline in the proportion of LRSC in the postpartum uterus. The LRSC returned to dormancy at PPD7, and the percentage of LRSC remained stable thereafter until 11 weeks. This study demonstrated that LRSC can respond efficiently to physiological stimuli upon initiation of uterine involution and return to its quiescent state after postpartum repair. PMID:25386902

Quantitative Measurement of GPCR Endocytosis via Pulse-Chase Covalent Labeling

PubMed Central

Fujishiro, Mitsuhiro; Okamura, Tomohisa; Fujio, Keishi; Okazaki, Hiroaki; Nomura, Seitaro; Takeda, Norifumi; Harada, Mutsuo; Toko, Haruhiro; Takimoto, Eiki; Akazawa, Hiroshi; Morita, Hiroyuki; Suzuki, Jun-ichi; Yamazaki, Tsutomu; Yamamoto, Kazuhiko; Komuro, Issei; Yanagisawa, Masashi

2015-01-01

G protein-coupled receptors (GPCRs) play a critical role in many physiological systems and represent one of the largest families of signal-transducing receptors. The number of GPCRs at the cell surface regulates cellular responsiveness to their cognate ligands, and the number of GPCRs, in turn, is dynamically controlled by receptor endocytosis. Recent studies have demonstrated that GPCR endocytosis, in addition to affecting receptor desensitization and resensitization, contributes to acute G protein-mediated signaling. Thus, endocytic GPCR behavior has a significant impact on various aspects of physiology. In this study, we developed a novel GPCR internalization assay to facilitate characterization of endocytic GPCR behavior. We genetically engineered chimeric GPCRs by fusing HaloTag (a catalytically inactive derivative of a bacterial hydrolase) to the N-terminal end of the receptor (HT-GPCR). HaloTag has the ability to form a stable covalent bond with synthetic HaloTag ligands that contain fluorophores or a high-affinity handle (such as biotin) and the HaloTag reactive linker. We selectively labeled HT-GPCRs at the cell surface with a HaloTag PEG ligand, and this pulse-chase covalent labeling allowed us to directly monitor the relative number of internalized GPCRs after agonist stimulation. Because the endocytic activities of GPCR ligands are not necessarily correlated with their agonistic activities, applying this novel methodology to orphan GPCRs, or even to already characterized GPCRs, will increase the likelihood of identifying currently unknown ligands that have been missed by conventional pharmacological assays. PMID:26020647

Best Practices Case Study: David Weekley Homes - Eagle Springs and Waterhaven, Houston, TX

DOE Office of Scientific and Technical Information (OSTI.GOV)

none,

2011-04-01

Case study describing David Weekley Homes, Houston Division, has qualified more than 1,240 homes for the DOE Builders Challenge. Advanced framed 2x6 walls with open headers and two-stud corners allow more room for R-20 damp sprayed cellulose wall cavity insulation that is covered with R-5 rigid XPS foam. A radiant barrier cuts heat gain in the R-38 insulated vented attics. Draft stopping at fireplace and duct chases and behind tubs, gluing sheetrock to framing, and extensive caulking make for air-tight homes at 3.0 ACH50.

Cognitive distortions and ADHD in pathological gambling: A national longitudinal case-control cohort study.

PubMed

Romo, Lucia; Legauffre, Cindy; Guilleux, Alice; Valleur, Marc; Magalon, David; Fatséas, Mélina; Chéreau-Boudet, Isabelle; Luquiens, Amandine; Vénisse, Jean-Luc; Grall-Bronnec, Marie; Challet-Bouju, Gaëlle

2016-12-01

Introduction The primary outcome of our study was to assess the links between the level of cognitive distortions and the severity of gambling disorder. We also aimed at assessing the links between patient gambling trajectories and attention deficit and hyperactivity disorder (ADHD). Materials and methods The study population (n = 628) was comprised of problem and non-problem gamblers of both sexes between 18 and 65 years of age, who reported gambling on at least one occasion during the previous year. Data encompassed socio-demographic characteristics, gambling habits, the South Oaks Gambling Screen, the Gambling Attitudes and Beliefs Survey - 23, the Wender Utah Rating Scale - Child, and the Adult ADHD Self-report Scale. Results The cognitive distortions with the greatest correlation to the severity of gambling disorder were the "Chasing" and "Emotions." These two dimensions were able to distinguish between problem gamblers seeking treatment or not. While age of onset of gambling and length of gambling practice were not associated with the level of distorted cognitions, a period of abstinence of at least 1 month was associated with a lower level of distorted cognitions. The presence of ADHD resulted in a higher level of distorted cognitions. Conclusion Cognitive work is essential to the prevention, and the treatment, of pathological gambling, especially with respect to emotional biases and chasing behavior. The instauration of an abstinence period of at least 1 month under medical supervision could be a promising therapeutic lead for reducing gambling-related erroneous thoughts and for improving care strategies of pathological gamblers.

Categorizing moving objects into film genres: the effect of animacy attribution, emotional response, and the deviation from non-fiction.

PubMed

Visch, Valentijn T; Tan, Ed S

2009-02-01

The reported study follows the footsteps of Heider, and Simmel (1944) [Heider, F., & Simmel, M. (1944). An experimental study of apparent behavior. American Journal of Psychology, 57, 243-249] and Michotte (1946/1963) [Michotte, A. (1963). The perception of causality (T.R. Miles & E. Miles, Trans.). London: Methuen (Original work published 1946)] who demonstrated the role of object movement in attributions of life-likeness to figures. It goes one step further in studying the categorization of film scenes as to genre as a function of object movements. In an animated film scene portraying a chase, movements of the chasing object were systematically varied as to parameters: velocity, efficiency, fluency, detail, and deformation. The object movements were categorized by viewers into genres: non-fiction, comedy, drama, and action. Besides this categorization, viewers rated their animacy attribution and emotional response. Results showed that non-expert viewers were consistent in categorizing the genres according to object movement parameters. The size of its deviation from the unmanipulated movement scene determined the assignment of any target scene to one of the fiction genres: small and moderate deviations resulted in categorization as drama and action, and large deviations as comedy. The results suggest that genre classification is achieved by, at least, three distinct cognitive processes: (a) animacy attribution, which influences the fiction versus non-fiction classification; (b) emotional responses, which influences the classification of a specific fiction genre; and (c) the amount of deviation from reality, at least with regard to movements.

NASA's Ship-Aircraft Bio-Optical Research (SABOR)

NASA Image and Video Library

2014-08-25

Catnap at Sea Ali Chase of the University of Maine, and Courtney Kearney of the Naval Research Laboratory, caught a quick nap on July 24, 2014, while between successive stops at sea to make measurements from the R/V Endeavor. NASA's Ship-Aircraft Bio-Optical Research (SABOR) experiment is a coordinated ship and aircraft observation campaign off the Atlantic coast of the United States, an effort to advance space-based capabilities for monitoring microscopic plants that form the base of the marine food chain. Read more: 1.usa.gov/WWRVzj Credit: NASA/SABOR/Wayne Slade, Sequoia Scientific..NASA image use policy. NASA Goddard Space Flight Center enables NASA’s mission through four scientific endeavors: Earth Science, Heliophysics, Solar System Exploration, and Astrophysics. Goddard plays a leading role in NASA’s accomplishments by contributing compelling scientific knowledge to advance the Agency’s mission. Follow us on Twitter Like us on Facebook Find us on Instagram

A Research Program in Computer Technology

DTIC Science & Technology

1975-09-01

Dale M. Chase Neil M. Goldman Jeannette Christen~sen Norton R. Green feld Kathie Cole grove John F. Heafner Nancy Dechter James Koda Oralio E. Garza...Thomas L. Boynton Stephen L. Casner E. Randolph Cole James Koda Robert Parker Paul Raveling Dono Van-Mierop Research Assistant: John K. Kastner

A Contemporary Blueprint for North Atlantic Treaty Organization Provisional Reconstruction Teams in Afghanistan?

DTIC Science & Technology

2006-05-25

States-led coalition, working in close cooperation with the Northern Alliance, succeeded in ousting the Taliban regime and chasing the remnants of its...Oxford University Press. Misra, Amalendu. 2004. Afghanistan: The Labyrinth of Violence. Cambridge, United Kingdom: Polity Press. Ralph, Magnus . 1998

Rogue States and Deterrence Strategy

DTIC Science & Technology

2009-04-02

United States leadership needs to recognize this recalcitrance- and stop condoning Iran’s behavior. Perkovich added, “we need to stop chasing them 20...1984), 141. 30 22 Magnus Ranstrop, “The Commission of Terrorist Attacks Upon the United States, March 31, 2003, http://www.9-11commission.gov/hearings

NOVA Fall 1998 Teacher's Guide.

ERIC Educational Resources Information Center

Colombo, Luann

This teacher's guide is designed to accompany the PBS television program "NOVA." Six science activities correspond to: (1) "Lost at Sea: The Search for Longitude,, which researches and charts the shortest course to circumnavigate the globe; (2) "Chasing El Nino," which formulates a question and designs an experiment to…

Chasing the Dream

ERIC Educational Resources Information Center

Gardezi, Aleena

2012-01-01

Community colleges are gearing up to play a greater role in providing open access and affordable education to undocumented immigrants since President Barack Obama's re-election, which ensured the continuance of his June 15th executive order offering deferred deportation to eligible young immigrants. That order provided an opportunity for children…

Principal as Curriculum Leader: Chase Manhattan Project.

ERIC Educational Resources Information Center

Petruzillo, Eileen; Scheinbart, Diane S.

1986-01-01

Describes a program initiated at a high school in New York City that identified learning styles of special education students in an effort to increase their achievement. Concludes that the program led to gains in motivation as well as achievement. Contains materials used to identify learning styles. (FL)

Chasing Shadows

ERIC Educational Resources Information Center

DeVore, Edna; Gould, Alan

2017-01-01

The solar eclipse coming August 21 offers students the opportunity not only to explore the geometry of the solar system but also to learn about exoplanets transiting distant stars. Students can glimpse a great frontier of science: the search for other worlds and life. This article presents information on exoplanets, discovering planets around…

Chasing Unachievable Outcomes

ERIC Educational Resources Information Center

Pangrazi, Robert P.

2010-01-01

Today, teachers complain about the lack of physical education time and the lack of physical education programming. In addition, a great deal of time is spent advocating the relationship between "healthy mind-healthy body." Today's drive to show a relationship between physical fitness/activity and academic achievement is really not different than…

Superresolution and pulse-chase imaging reveal the role of vesicle transport in polar growth of fungal cells

PubMed Central

Zhou, Lu; Evangelinos, Minoas; Wernet, Valentin; Eckert, Antonia F.; Ishitsuka, Yuji; Fischer, Reinhard; Nienhaus, G. Ulrich; Takeshita, Norio

2018-01-01

Polarized growth of filamentous fungi requires continuous transport of biomolecules to the hyphal tip. To this end, construction materials are packaged in vesicles and transported by motor proteins along microtubules and actin filaments. We have studied these processes with quantitative superresolution localization microscopy of live Aspergillus nidulans cells expressing the photoconvertible protein mEosFPthermo fused to the chitin synthase ChsB. ChsB is mainly located at the Spitzenkörper near the hyphal tip and produces chitin, a key component of the cell wall. We have visualized the pulsatory dynamics of the Spitzenkörper, reflecting vesicle accumulation before exocytosis and their subsequent fusion with the apical plasma membrane. Furthermore, high-speed pulse-chase imaging after photoconversion of mEosFPthermo in a tightly focused spot revealed that ChsB is transported with two different speeds from the cell body to the hyphal tip and vice versa. Comparative analysis using motor protein deletion mutants allowed us to assign the fast movements (7 to 10 μm s−1) to transport of secretory vesicles by kinesin-1, and the slower ones (2 to 7 μm s−1) to transport by kinesin-3 on early endosomes. Our results show how motor proteins ensure the supply of vesicles to the hyphal tip, where temporally regulated exocytosis results in stepwise tip extension. PMID:29387789

Gambling Harm and Crime Careers.

PubMed

May-Chahal, Corinne; Humphreys, Leslie; Clifton, Alison; Francis, Brian; Reith, Gerda

2017-03-01

Incarcerated populations across the world have been found to be consistently and significantly more vulnerable to problem gambling than general populations in the same countries. In an effort to gain a more specific understanding of this vulnerability the present study applied latent class analysis and criminal career theory to gambling data collected from a sample of English and Scottish, male and female prisoners (N = 1057). Theoretical links between gambling and crime were tested through three hypotheses: (1) that prisoners in the UK would have higher rates of problem gambling behaviour than the national population; (2) that if the link between gambling and crime is coincidental, gambling behaviour would be highly prevalent in an offending population, and (3) if connections between gambling behaviour and offending are co-symptomatic a mediating factor would show a strong association. The first of these was supported, the second was not supported and the third was partially supported. Latent class analysis found six gambling behaviour clusters measured by responses to the Problem Gambling Severity Index, primarily distinguished by loss chasing behaviour. Longitudinal offending data drawn from the Police National Computer database found four criminal career types, distinguished by frequency and persistence over time. A significant association was found between higher level loss chasing and high rate offending in criminal careers suggesting that impulse control may be a mediating factor for both gambling harm and criminal careers.

Regulation of accumulation of ammonium-inducible glutamate dehydrogenase catalytic activity and antigen during the cell cycle of fully induced, synchronous Chlorella sorokiniana cells.

PubMed

Yeung, A T; Bascomb, N F; Turner, K J; Schmidt, R R

1981-05-01

By use of a rocket immunoelectrophoresis-activity stain procedure, it was shown that catalytic activity of an ammonium-inducible nicotinamide adenine dinucleotide phosphate-specific glutamate dehydrogenase (NADP-GDH) was accompanied by a coincident increase in enzyme antigen during the cell cycle of preinduced synchronous Chlorella sorokiniana cells growing in the continuous presence of ammonia. Between the fourth and fifth hours of the G-1 phase of the cell cycle, a three- to fourfold increase in linear accumulation of enzyme antigen was observed. Pulse-chase studies with [35S]sulfate, coupled with a specific indirect immunoadsorption procedure for enzyme antigen, showed that NADP-GDH antigen undergoes continuous degradation (i.e., a half-life of 88 to 110 min) during its linear pattern of accumulation during the cell cycle. The apparent half-life of the enzyme increased by approximately 23% of the 4.5-h positive rate change in antigen accumulation during the cell cycle. This increase in half-life is insufficient in itself to account for the large change in rate of NADP-GDH antigen accumulation. The data from immunoelectrophoresis, pulse-chase, and initial 35S incorporation rate experiments taken together support the inference that changes in the rate of NADP-GDH synthesis are primarily responsible for the accumulation patterns of NADP-GDH activity during the C. sorokiniana cell cycle.

Lysosomal Membrane Glycoproteins: Properties of LAMP-1 (Lysosome Associated Membrane Protein) and LAMP-2

DTIC Science & Technology

1985-01-01

Biosnthesis of th - Glvcooro ins Precursor forms of L ,MP-1 anc L.,. 2 ann process i’ :o n ecu w er’ examined by pulse -chase Iabeling ann,, recipcian. c t i...in the oresence of deterqent. 4 -",W Studies of the biosynthesis and process inn of the qL/cnDroteins showed that each contained a polypeptide core of...pDroximatelv 43,000 dal tons as identified by use of tunicarnycin and endolvcosidase H. Nascent glycooroteins pulse -labeled for 5 min with [3S

Combat History Analysis Study Effort (CHASE)

DTIC Science & Technology

1986-08-01

DE ; DEC JAN FEB JUL 2 8 KIMBERLY 11 KIHBERLY 15 LADYSMITH 24 LADYSHITH 18 LADYSHITH 1 SANTIAGO ...dates over time, along with some other des - criptive statistics of the material in the HERO data base, is discussed in Chapter 3. The HERO data base...Engagement O ■’-4 II i *J o ■H -H ^ ^. —1 U It For ce Pr ep on - de ra nc e 1 a V 2 .5 i2S it s o ’Si in’ S tH 71 u ■H 3 iW

Cognitive distortions among older adult gamblers in an Asian context

PubMed Central

Subramaniam, Mythily; Chong, Siow Ann; Browning, Colette; Thomas, Shane

2017-01-01

Aims The study aims to describe the construct of cognitive distortions based on the narratives of older adult gamblers (aged 60 years and above) in Singapore. Methods Singapore residents (citizens or permanent residents) aged 60 years and above, who were current or past regular gamblers were included in the study. Participants were recruited using a combination of venue based approach, referrals from service providers as well as by snowball sampling. In all, 25 in-depth interviews were conducted with older adult gamblers. The six-step thematic network analysis methodology was adopted for data analysis. Results The mean age of the participants was 66.2 years. The majority were male (n = 18), of Chinese ethnicity (n = 16), with a mean age of gambling initiation at 24.5 years. Among older adult gamblers, cognitive distortions emerged as a significant global theme comprising three organizing themes–illusion of control, probability control and interpretive control. The organizing themes comprised nine basic themes: perception of gambling as a skill, near miss, concept of luck, superstitious beliefs, entrapment, gambler’s fallacy, chasing wins, chasing losses, and beliefs that wins are more than losses. Conclusions Cognitive distortions were endorsed by all gamblers in the current study and were shown to play a role in both maintaining and escalating the gambling behaviour. While the surface characteristics of the distortions had a culture-specific appearance, the deeper characteristics of the distortions may in fact be more universal than previously thought. Future research must include longitudinal studies to understand causal relationships between cognitive distortions and gambling as well as the role of culture-specific distortions both in the maintenance and treatment of the disorder. PMID:28542389

How We Think and Learn. Lecture Series.

ERIC Educational Resources Information Center

National Learning Center, Washington, DC.

A lecture series was conducted in 1989 to present information on learning theories by learning theorists. This document contains short texts of the lectures; full texts are available on request. In lecture 1, Robert Chase discusses educational reform and Bonnie Guiton examines educational goals from the perspective of White House policy. In…

Game Changer: Linked Learning Detroit

ERIC Educational Resources Information Center

ConnectEd: The California Center for College and Career, 2016

2016-01-01

JP Morgan Chase joins the Skillman Foundation, the Ford Foundation, and the Ford Motor Company Fund, whose grants total $7 million and will connect 10,000 Detroit high school students to career education and work experiences over the next three years through Linked Learning Detroit. Learn about Linked Learning Detroit through interviews with…

Library Students Are "Breaking Good" with Saul Goodman's Advice

ERIC Educational Resources Information Center

Turkewitz, Deborah

2014-01-01

Graduate students are taking big steps and stretching themselves, whether returning to school midpoint in their lives, taking classes on unfamiliar topics, or starting internships and trying to put theory into practice. Who better to offer advice to these graduate students than America's favorite hilarious, morally ambiguous, ambulance-chasing,…

75 FR 75698 - Sunshine Act Notice

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-06

... DEPARTMENT OF JUSTICE Parole Commission Sunshine Act Notice Public Announcement; Pursuant to the Government in the Sunshine Act (Pub. L. 94-409) [5 U.S.C. Section 552b] DATE AND TIME: 12 a.m., Tuesday, December 7, 2010. PLACE: U.S. Parole Commission, 5550 Friendship Boulevard, 4th Floor Chevy Chase, Maryland...

Integrating Literature and Mathematics: A Mysterious Connection

ERIC Educational Resources Information Center

Wilburne, Jane Murphy; Napoli, Mary

2007-01-01

This article describes a mathematics and literature interdisciplinary project for preservice elementary teachers that was implemented in several urban middle school classrooms. This project, based on the novel Chasing Vermeer by Balliett (2004), involved a dramatization of one of the chapters from the book and a follow-up mathematical exploration.

A Historical Omission

ERIC Educational Resources Information Center

Stuart, Reginald

2007-01-01

For nearly a decade, Dr. Maggie Rivas-Rodriguez and a small army of students and volunteer colleagues around the country have been aggressively chasing and documenting a rapidly vanishing chapter of American history--the American Latino and Latina experience during World War II. Along the way, they recorded nearly 600 interviews of about two…

4. Northeast corner of quarters (executive officer's quarters), looking onto ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. Northeast corner of quarters (executive officer's quarters), looking onto Quarter R (commanding officer's quarters), looking southeast - Naval Air Station Chase Field, Texas State Highway 202, 4.8 miles east of intersection of Texas State Highway 202 & U.S. State Highway 181, Beeville, Bee County, TX

2. Overview of Buildings 2015, 2133 and 2009, with Building ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. Overview of Buildings 2015, 2133 and 2009, with Building 1001 (administration building) in background, looking northeast - Naval Air Station Chase Field, Texas State Highway 202, 4.8 miles east of intersection of Texas State Highway 202 & U.S. State Highway 181, Beeville, Bee County, TX

77 FR 71365 - Proposed Establishment of Class E Airspace; Beeville, TX

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-30

... accommodate new Standard Instrument Approach Procedures (SIAPs) at Chase Field Industrial Airport. The FAA is taking this action to enhance the safety and management of Instrument Flight Rules (IFR) operations for.... ADDRESSES: Send comments on this proposal to the U.S. Department of [[Page 71366

Pegasus Engine Ignites after Drop from B-52 Mothership

NASA Image and Video Library

1991-07-17

Against the midnight blue of a high-altitude sky, Orbital Sciences’ Pegasus winged rocket booster ignites after being dropped from NASA’s B-52 mothership on a July 1991 flight. A NASA chase plane for the flight is also visible above the rocket and below the B-52.

29. PLAN OF THE ARVFS FIELD TEST FACILITY SHOWING BUNKER, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

29. PLAN OF THE ARVFS FIELD TEST FACILITY SHOWING BUNKER, CABLE CHASE, SHIELDING TANK AND FRAME ASSEMBLY. F.C. TORKELSON DRAWING NUMBER 842-ARVFS-701-1. INEL INDEX CODE NUMBER: 075 0701 851 151970. - Idaho National Engineering Laboratory, Advanced Reentry Vehicle Fusing System, Scoville, Butte County, ID

North Carolina's Approach: Developing a Bio-Tech Workforce

ERIC Educational Resources Information Center

Smit, Norman

2004-01-01

States across the country are all chasing what are becoming known as "new-age" technologies. These are technologies such as biotechnology, nanotechnology, bio-informatics and others. These technologies offer the potential for long-term economic growth and well-paid jobs to employees working in these sectors. As these technologies mature,…

Autoradiography and the Cell Cycle.

ERIC Educational Resources Information Center

Jones, C. Weldon

1992-01-01

Outlines the stages of a cell biology "pulse-chase" experiment in which the students apply autoradiography techniques to learn about the concept of the cell cycle. Includes (1) seed germination and plant growth; (2) radioactive labeling and fixation of root tips; (3) feulgen staining of root tips; (4) preparation of autoradiograms; and…

An updated comprehensive annotated list of the butterflies (Lepidoptera: Rhopalocera) occurring at Chase Lake National Wildlife Refuge Complex Stutsman County, North Dakota 1995-1996

USGS Publications Warehouse

Royer, Ron

1996-01-01

A project to produce a comprehensive, site-specific butterfly list that could serve as a basis for future monitoring of butterfly populations and as an aid in making management decisions for the area.

Chasing the Wolves from the Schoolhouse Door.

ERIC Educational Resources Information Center

Kowalski, Theodore

1995-01-01

Warnings about the deterioration of America's schoolhouses have generated only limited public reaction. State legislators, governors, federal officials, and corporate executives who reacted to "A Nation at Risk" have remained silent--perhaps because lots of money is needed to fix the problem. This article explains the effects of physical…

Problem-Based Test: Replication of Mitochondrial DNA during the Cell Cycle

ERIC Educational Resources Information Center

Setalo, Gyorgy, Jr.

2013-01-01

Terms to be familiar with before you start to solve the test: cell cycle, generation time, S-phase, cell culture synchronization, isotopic pulse-chase labeling, density labeling, equilibrium density-gradient centrifugation, buoyant density, rate-zonal centrifugation, nucleoside, nucleotide, kinase enzymes, polymerization of nucleic acids,…

GISD

Science.gov Websites

GISD Global invasive species database Home About the GISD How to use Contacts 100 of the worst ) Bromus rubens Line drawing of Bromus rubens (USDA-NRCS PLANTS Database / Hitchcock, A.S. (rev. A. Chase GISD ISPRA SNPA The Global Invasive Species Database was developed and is managed by the Invasive

Inclusion Strategies for Students with Learning and Behavior Problems: Perspectives, Experiences, and Best Practices.

ERIC Educational Resources Information Center

Zionts, Paul, Ed.

This book presents discussions of the practical implementation of inclusion principles with students having learning and/or behavioral problems and disorders. The chapters, arranged under two topical units, "Perspectives and Experiences" and "Best Practices" are: (1) "Inclusion: Chasing the Impossible Dream? Maybe"…

Oracy II.

ERIC Educational Resources Information Center

Nebraska Univ., Lincoln.

This volume on the Tri-University project contains three reports on the teaching of oracy. The chairman of the committee on oracy, Laura Chase, offers suggestions for the preservice and inservice training of teachers to prepare them to deal with discussion, the individual talk, oral reading, and dramatic role playing. She outlines a teacher…

THE EFFECT OF OZONE ON BELOW-GROUND CARBON ALLOCATION IN WHEAT

EPA Science Inventory

Short term 14CO2 pulse and chase experiments were conducted in order to investigate the effect ozone on below-ground carbon allocation in spring wheat seedlings (Triticum aestivumL. ?ANZA'). Wheat seedlings were grown in a sand-hydroponic system and exposed to either high ozone ...

Chasing Personal Meaning: Pedagogical Lessons through Luis Rodriguez's "Always Running"

ERIC Educational Resources Information Center

Theisen-Homer, Victoria

2014-01-01

In this autobiographical narrative, the author recounts her experiences teaching the novel "Always Running" by Luis Rodriguez with her English classes at a high school in a gang-heavy area. When she first started teaching, this teacher struggled to engage students. One particularly disruptive student requested to read "Always…

Global Proliferation-Dynamics, Acquisition Strategies, and Responses. Volume 2. Nuclear Proliferation

DTIC Science & Technology

1994-09-01

due to Marvin Atkins, Joel Bengston. Richard Blumstein. John Bulger, James Bushong, Burrus Carnahan, Alexis Castor, Emerory Chase, Edward Chaves...SCIENCE BOARDATTN: DR P G K MINSKI OSD (DDR&E) ATTN: DR VICTOR REIS DEPUTY ASSISTANT SECRETARY OSD COMPTROLLER ATTN: JANE MATTHIAS ATTN: HONORABLE JOHN

Prime Contractors | Division of Cancer Prevention

Cancer.gov

2015-2018 Efficacy and Intermediate Endpoint Biomarkers: The Research Institute of Fox Chase Cancer Center SRI International IIT Research Institute University of Texas MD Anderson Cancer Center University of Alabama at Birmingham Medical College of Wisconsin University of Oklahoma Health Sciences Center Weill Medical College of Cornell University Toxicology and Pharmacology

Stream-water and groundwater quality in and near the Citizen Potawatomi Nation Tribal Jurisdictional Area, Pottawatomie County, Oklahoma, 2012-13

USGS Publications Warehouse

Becker, Carol J.

2014-01-01

Concentrations of the radionuclide uranium ranged from 0.03 to 79.5 µg/L, with a median concentration of 1.9 µg/L in the 30 groundwater samples collected. Two of the groundwater samples collected for this study had uranium concentrations exceeding the MCL of 30 µg/L, with concentrations of 79.5 and 31.1 µg/L. Generally, uranium concentrations were highest in water samples collected from wells completed in the Wellington Formation and the Chase, Council Grove, and Admire Groups in the southern and eastern parts of the study area.

Electronic gaming machines and gambling disorder: A cross-cultural comparison between treatment-seeking subjects from Brazil and the United States.

PubMed

Medeiros, Gustavo C; Leppink, Eric W; Yaemi, Ana; Mariani, Mirella; Tavares, Hermano; Grant, Jon E

2015-12-15

The objective of this paper is to perform a cross-cultural comparison of gambling disorder (GD) due to electronic gaming machines (EGM), a form of gambling that may have a high addictive potential. Our goal is to investigate two treatment-seeking samples of adults collected in Brazil and the United States, countries with different socio-cultural backgrounds. This comparison may lead to a better understanding of cultural influences on GD. The total studied sample involved 733 treatment-seeking subjects: 353 men and 380 women (average age=45.80, standard deviation ±10.9). The Brazilian sample had 517 individuals and the American sample 216. Subjects were recruited by analogous strategies. We found that the Brazilian sample was younger, predominantly male, less likely to be Caucasian, more likely to be partnered, tended to have a faster progression from recreational gambling to GD, and were more likely to endorse chasing losses. This study demonstrated that there are significant differences between treatment-seeking samples of adults presenting GD due to EGM in Brazil and in the United States. These findings suggest that cultural aspects may have a relevant role in GD due to EGM. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Absorption Kinetics of Phage Lambda on Its Host Under Shear Flow

NASA Astrophysics Data System (ADS)

Yip, C. W.; Wu, X. L.

2000-03-01

Classical blender experiment by Hershey and Chase played a seminal role in illustrating the infectious process of bacteriophage to its host, and showed unequivocally that DNA is responsible for the transmission of heredity. Subsequent works by others have established that interaction between phage particles and bacterial cells is a diffusion-limited process in that, statistically speaking, each collision results in an irreversible infection. However, such a result is hard to reconcile with the fact that the infection appears to be independent of the density of phage receptors on the bacterial cell membrane. Thus, quantitative experiments showing how a phage finds its receptor and how long does it take would be valuable to this paradoxical view. Simple calculations based on Brownian motion of the phage particles show that the interaction time between the receptor and the phage is given by tau=b^2/(5D), where b is the length of the phage and D is its diffusion coefficient. Using a shear flow apparatus we study absorption kinetics of lambda phage on E. Coli (strain YMEL) under different flow conditions, and the results are compared with a simple diffusion model taking into account the hydrodynamic convection and the interaction time tau.

Motorboat noise disrupts co-operative interspecific interactions.

PubMed

Nedelec, Sophie L; Mills, Suzanne C; Radford, Andrew N; Beldade, Ricardo; Simpson, Stephen D; Nedelec, Brendan; Côté, Isabelle M

2017-08-01

Human-made noise is contributing increasingly to ocean soundscapes. Its physical, physiological and behavioural effects on marine organisms are potentially widespread, but our understanding remains largely limited to intraspecific impacts. Here, we examine how motorboats affect an interspecific cleaning mutualism critical for coral reef fish health, abundance and diversity. We conducted in situ observations of cleaning interactions between bluestreak cleaner wrasses (Labroides dimidiatus) and their fish clients before, during and after repeated, standardised approaches with motorboats. Cleaners inspected clients for longer and were significantly less cooperative during exposure to boat noise, and while motorboat disturbance appeared to have little effect on client behaviour, as evidenced by consistency of visit rates, clientele composition, and use of cleaning incitation signals, clients did not retaliate as expected (i.e., by chasing) in response to increased cheating by cleaners. Our results are consistent with the idea of cognitive impairments due to distraction by both parties. Alternatively, cleaners might be taking advantage of distracted clients to reduce their service quality. To more fully understand the importance of these findings for conservation and management, further studies should elucidate whether the efficacy of ectoparasite removal by cleaners is affected and explore the potential for habituation to boat noise in busy areas.

Promoting the uptake of HIV testing among men who have sex with men: systematic review of effectiveness and cost-effectiveness.

PubMed

Lorenc, Theo; Marrero-Guillamón, Isaac; Aggleton, Peter; Cooper, Chris; Llewellyn, Alexis; Lehmann, Angela; Lindsay, Catriona

2011-06-01

What interventions are effective and cost-effective in increasing the uptake of HIV testing among men who have sex with men (MSM)? A systematic review was conducted of the following databases: AEGIS, ASSIA, BL Direct, BNI, Centre for Reviews and Dissemination, Cochrane Database of Systematic Reviews, CINAHL, Current Contents Connect, EconLit, EMBASE, ERIC, HMIC, Medline, Medline In-Process, NRR, PsychINFO, Scopus, SIGLE, Social Policy and Practice, Web of Science, websites, journal hand-searching, citation chasing and expert recommendations. Prospective studies of the effectiveness or cost-effectiveness of interventions (randomised controlled trial (RCT), controlled trial, one-group or any economic analysis) were included if the intervention aimed to increase the uptake of HIV testing among MSM in a high-income (Organization for Economic Co-operation and Development) country. Quality was assessed and data were extracted using standardised tools. Results were synthesised narratively. Twelve effectiveness studies and one cost-effectiveness study were located, covering a range of intervention types. There is evidence that rapid testing and counselling in community settings (one RCT), and intensive peer counselling (one RCT), can increase the uptake of HIV testing among MSM. There are promising results regarding the introduction of opt-out testing in sexually transmitted infection clinics (two one-group studies). Findings regarding other interventions, including bundling HIV tests with other tests, peer outreach in community settings, and media campaigns, are inconclusive. Findings indicate several promising approaches to increasing HIV testing among MSM. However, there is limited evidence overall, and evidence for the effectiveness of key intervention types (particularly peer outreach and media campaigns) remains lacking.

Protein Turnover Measurements in Human Serum by Serial Immunoaffinity LC-MS/MS.

PubMed

Farrokhi, Vahid; Chen, Xiaoying; Neubert, Hendrik

2018-02-01

The half-life of target proteins is frequently an important parameter in mechanistic pharmacokinetic and pharmacodynamic (PK/PD) modeling of biotherapeutics. Clinical studies for accurate measurement of physiologically relevant protein turnover can reduce the uncertainty in PK/PD model-based predictions, for example, of the therapeutic dose and dosing regimen in first-in-human clinical trials. We used a targeted mass spectrometry work flow based on serial immunoaffinity enrichment ofmultiple human serum proteins from a [5,5,5- 2 H 3 ]-L-leucine tracer pulse-chase study in healthy volunteers. To confirm the reproducibility of turnover measurements from serial immunoaffinity enrichment, multiple aliquots from the same sample set were subjected to protein turnover analysis in varying order. Tracer incorporation was measured by multiple-reaction-monitoring mass spectrometry and target turnover was calculated using a four-compartment pharmacokinetic model. Five proteins of clinical or therapeutic relevance including soluble tumor necrosis factor receptor superfamily member 12A, tissue factor pathway inhibitor, soluble interleukin 1 receptor like 1, soluble mucosal addressin cell adhesion molecule 1, and muscle-specific creatine kinase were sequentially subjected to turnover analysis from the same human serum sample. Calculated half-lives ranged from 5-15 h; however, no tracer incorporation was observed for mucosal addressin cell adhesion molecule 1. The utility of clinical pulse-chase studies to investigate protein turnover can be extended by serial immunoaffinity enrichment of target proteins. Turnover analysis from serum and subsequently from remaining supernatants provided analytical sensitivity and reproducibility for multiple human target proteins in the same sample set, irrespective of the order of analysis. © 2017 American Association for Clinical Chemistry.

Choosing a School Turnaround Provider. Lessons Learned. Volume 1, Issue 3

ERIC Educational Resources Information Center

Lockwood, Anne Turnbaugh; Fleischman, Steve

2010-01-01

Droves of school turnaround providers are chasing the massive federal infusion of funds flowing into failing schools. They arrive armed with glossy materials, impressive sounding claims, and, often, citing their prior relationships or experiences with one's school to support their promises of great service and impressive outcomes. But, are their…

This Is About Attendance Counselling.

ERIC Educational Resources Information Center

Prokos, George

The days of the formidable truant officer who chased after hooky-playing delinquents and led them back to school by the ear are gone. Today's "attendance counselors" see their function as protecting a child's right to a meaningful education. Although their goal is still to get absent students back to classes, their approach is now a more…

A Connectionist/Control Architecture for Working Memory and Workload: Why Working Memory Is Not 7+ /-2

DTIC Science & Technology

1987-09-29

load on the centra and regional controllers. Strategy #S: Reduce message Chase. W.G., & Ericsson. K.A. ( 1082 ). Skill andInterference of concurrently...bypsycholocy Lf learning and motivation. Vol. Ia. strengthening region. to,.region connections on theNeYokAcdmcPs. innerlooip. Crowder, R.G. ( 1082

75 FR 36441 - National Register of Historic Places; Notification of Pending Nominations and Related Actions

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-25

... 7th St, Hiawatha, 10000450 Chase County Shaft, William C. & Jane, House, 1682 FP Rd, Cedar Point..., Bat St. Louis, 10000441 Hinds County George Street Grocery, 416 George St, Jackson, 10000438 Leflore... Grocer Company Warehouse, 323 N. Patton Ave, Springfield, 10000462 Jackson County Montgomery Ward and...

75 FR 35831 - National Register of Historic Places; Notification of Pending Nominations and Related Actions

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-23

... 7th St, Hiawatha, 10000450 Chase County Shaft, William C. & Jane, House, 1682 FP Rd, Cedar Point... * * *, Bat St. Louis, 10000441 Hinds County George Street Grocery, 416 George St, Jackson, 10000438 [[Page... Springfield Grocer Company Warehouse, 323 N. Patton Ave, Springfield, 10000462 Jackson County Montgomery Ward...

29. July 1974. WOOD SHOP, VIEW LOOKING SOUTHEAST AT THE ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

29. July 1974. WOOD SHOP, VIEW LOOKING SOUTHEAST AT THE BELT CHASE FOR THE TRANSMISSION OF POWER FROM THE MAIN LINE-SHAFT BELOW TO THE MACHINES ALONG THE EAST WALL OF THE WOOD SHOP. - Gruber Wagon Works, Pennsylvania Route 183 & State Hill Road at Red Bridge Park, Bernville, Berks County, PA

Chasing the Butterfly Effect: Informal Language Learning Online as a Complex System

ERIC Educational Resources Information Center

Godwin-Jones, Robert

2018-01-01

Evidence is accumulating that a major shift is underway in the ways that second language (L2) development is taking place. Increasingly, especially among young people, that process is occurring outside of institutional settings, predominately through the use of online networks and media. That phenomenon has been particularly noticed for learners…

76 FR 35225 - National Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-16

... meeting. The meeting will be closed to the public in accordance with the provisions set forth in sections.... Place: Courtyard by Marriott, 5520 Wisconsin Avenue, Chevy Chase, MD 20815. Contact Person: Charles N...-5019, charles[email protected] . (Catalogue of Federal Domestic Assistance Program Nos. 93.846...

78 FR 23800 - JPMorgan Chase & Co., et al.; Notice of Application

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-22

... certified public accountants,\\10\\ except under certain circumstances in the case of Partnerships formed to make a single Portfolio Investment.\\11\\ As soon as practicable after the end of each tax year of a..., losses, credits, deductions, and other tax items for U.S. federal income tax purposes, resulting from the...

Chasing the College Dream in Hard Economic Times. Issue Brief

ERIC Educational Resources Information Center

Buddin, Richard; Croft, Michelle

2014-01-01

Slow economic growth in the past several years has strained the financial resources of many American families and heightened financial burdens for families hoping to support their children's college education. These economic struggles come at a critical time for high school students who rely on family resources to fund large portions of college…

Legal, Tender: The Deferred Romance of Pedagogical Relation in "The Paper Chase"

ERIC Educational Resources Information Center

Stillwaggon, James; Jelinek, David

2011-01-01

Films depicting educational relationships typically emphasize personal connections between students and teachers over the educational goals that such relations facilitate. In doing so, these films raise the question of how teachers stand in relation to their institutional roles in such a way as to inspire students' desires for knowledge. In this…

COLREGS-Compliant Autonomous Collision Avoidance Using Multi-Objective Optimization with Interval Programming

DTIC Science & Technology

2014-06-01

chasing our robots on the River as well as hiking out trying desperately not to capsize our super fast sailboat...again. To my unofficial advisors... Mario Bollini, Tan Yew (William) Teck, the Dan Codiga and the University of Rhode Island team, the MIT 2.680 course staff, and certainly the many

On the "Give" and "Take" between Event Apprehension and Utterance Formulation

ERIC Educational Resources Information Center

Gleitman, Lila R.; January, David; Nappa, Rebecca; Trueswell, John C.

2007-01-01

Two experiments are reported that examine how manipulations of visual attention affect speakers' linguistic choices regarding word order, verb use and syntactic structure when describing simple pictured scenes. Experiment 1 presented participants with scenes designed to elicit the use of a perspective predicate ("The man chases the dog/The dog…

75 FR 37453 - National Eye Institute; Amended Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-29

... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Eye Institute; Amended Notice of Meeting Notice is hearby given of a chance in the meeting of the National Eye Institute Special Emphasis Panel, July 16, 2010, 8 a.m. to July 16, 2010, 5 p.m., Embassy Suites Hotel, Chevy Chase...

The Coevolution of "Tyrannosaurus" & Its Prey: Could "Tyrannosaurus" Chase down & Kill a "Triceratops" for Lunch?

ERIC Educational Resources Information Center

May, S. Randolph

2014-01-01

Students will analyze the coevolution of the predator-prey relationships between "Tyrannosaurus rex" and its prey species using analyses of animal speeds from fossilized trackways, prey-animal armaments, adaptive behaviors, bite marks on prey-animal fossils, predator-prey ratios, and scavenger competition. The students will be asked to…

Rosenberger v. Rector: The First Amendment Dog Chases Its Tail.

ERIC Educational Resources Information Center

Roth, Charles

1995-01-01

Discussion of the Rosenberger vs. Rector case, involving the ability of public universities to decide whether or not to fund religious speech, evaluates contemporary jurisprudence concerning the establishment and free speech clauses and applies theories in these areas to funding of student religious speech on college campuses. It also outlines…

3. Overview of Essex Street, with Building 1042 (brig) in ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

3. Overview of Essex Street, with Building 1042 (brig) in foreground and Building 1009 (enlisted waves barracks), toward rear, looking northwest - Naval Air Station Chase Field, Texas State Highway 202, 4.8 miles east of intersection of Texas State Highway 202 & U.S. State Highway 181, Beeville, Bee County, TX

30. ELEVATION OF ARVFS FIELD TEST FACILITY SHOWING VIEW OF ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

30. ELEVATION OF ARVFS FIELD TEST FACILITY SHOWING VIEW OF SOUTH SIDE OF FACILITY, INCLUDING BUNKER, CABLE CHASE, SHIELDING TANK, AND FRAME ASSEMBLY. F.C. TORKELSON DRAWING NUMBER 842-ARVFS-701-2. INEL INDEX CODE NUMBER: 075 0701 851 151971. - Idaho National Engineering Laboratory, Advanced Reentry Vehicle Fusing System, Scoville, Butte County, ID

7. CONSTRUCTION PROGRESS VIEW (INTERIOR) OF CONTROL ROOM PANEL INSIDE ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

7. CONSTRUCTION PROGRESS VIEW (INTERIOR) OF CONTROL ROOM PANEL INSIDE BUNKER. SHOWS OPENING TO CABLE CHASE, FOUR PULLEY DEVICES, POWER OUTLET, CONDUIT, AND EAST END WALL OF BUNKER. INEL PHOTO NUMBER 65-5441, TAKEN OCTOBER 20, 1965. - Idaho National Engineering Laboratory, Advanced Reentry Vehicle Fusing System, Scoville, Butte County, ID

The Guardians Initiative: A Student-Centered Approach to Bullying

ERIC Educational Resources Information Center

Toledo, Gregory

2008-01-01

Something wicked is being chased out of the classrooms and hallways at a high school in Massachusetts, something prevalent in schools across the globe: bullying. For generations, victims have carried invisible scars or nursed open wounds. Concerns related to bullying have been confirmed by extensive research over the past decade, including…

Engineering Encounters: A House for Chase the Dog

ERIC Educational Resources Information Center

Marrero, Meghan E.; Gunning, Amanda M.; Buonamano, Christina

2016-01-01

From a young age, children encounter different materials and learn color, hardness, texture, and shape. Focusing on observable properties is an engaging way to introduce young children to matter. In this investigation, students use observations and engineering design to decide which material would make the best roof for a doghouse. The authors…

75 FR 3251 - JP Morgan Chase and Company; JP Morgan Investment Banking, Global Corporate Financial Operations...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-20

... Company; JP Morgan Investment Banking, Global Corporate Financial Operations, New York, NY; Notice of... Company, JP Morgan Investment Banking, Global Corporate Financial Operations, New York, New York. The... support operations to/from a foreign country. The subject firm did not import services like or directly...

SuperLab LT: Evaluation and Uses in Teaching Experimental Psychology

ERIC Educational Resources Information Center

Ragozzine, Frank

2002-01-01

I describe and evaluate SuperLab LT (Chase & Abboud, 1990), a software package that enables students to replicate classic experiments in cognitive psychology. I also discuss the package with respect to its uses in teaching an undergraduate course in Experimental Psychology. Although the package has minor flaws, SuperLab LT provides numerous…

Seasons by the Sun

ERIC Educational Resources Information Center

Stark, Meri-Lyn

2005-01-01

Understanding the Sun has challenged people since ancient times. Mythology from the Greek, Inuit, and Inca cultures attempted to explain the daily appearance and nightly disappearance of the Sun by relating it to a chariot being chased across the sky. While people no longer believe the Sun is a chariot racing across the sky, teachers are still…

Integrating Fast and Slow Cognitive Processes

DTIC Science & Technology

2010-08-01

Stroop’s paradigm." Psychonomic Bulletin & Review , 8(2), 324-330. Chase M. H. & Morales, F. R. (2005). Control of motoneurons during sleep. In M. H... Psychonomic Bulletin & Review , 18, 987-999. Zehr, E. P., & Stein, R. B., Interaction of the Jendrassik maneuver with segmental presnaptic inhibitation. Experimental Brain Research, 124 (4), 474-480. 126

Chasing Butterflies without a Net: Interpreting Cosmopolitanism

ERIC Educational Resources Information Center

Hansen, David T.

2010-01-01

In this article, I map current conceptions of cosmopolitanism and sketch distinctions between the concept and humanism and multiculturalism. The differences mirror what I take to be a central motif of cosmopolitanism: the capacity to fuse reflective openness to the new with reflective loyalty to the known. This motif invites a reconsideration of…

Teacher Education for Rural-Regional Sustainability: Changing Agendas, Challenging Futures, Chasing Chimeras?

ERIC Educational Resources Information Center

Green, Bill; Reid, Jo-Anne

2004-01-01

Rural schooling has remained a concern for policy-makers, employers, teacher education providers and schools throughout our recent history. In particular, the allegedly variable quality of teaching and learning in rural Australia is a major concern for teacher educators and educational leaders alike, with the provision of quality services for…

Chasing Ambiguity: Critical Reflections on Working with Dance Graduates

ERIC Educational Resources Information Center

Roe, Sarah

2017-01-01

This paper questions whether are we able to foster uncertainty and ambiguity within higher education arts programmes, specifically alongside current institutional demands and embedded pedagogies. If not, then what effect does this have on current dance graduates? I attend to these questions through critical reflections upon my work as a pedagogue,…

Conducting a Community-Based Experiential-Learning Project to Address Youth Fitness

ERIC Educational Resources Information Center

Petersen, Jeffrey C.; Judge, Lawrence; Pierce, David A.

2012-01-01

There is a need within health, physical education, recreation, dance, and sport programs to increase community engagement via experiential learning. The Chase Charlie Races are presented in this article as a model pedagogical strategy to engage community youths and families in a training program and running event to help promote fitness. Key…

37. July 1974. WOOD SHOP, VIEW LOOKING NORTHWEST, SHOWING THE ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

37. July 1974. WOOD SHOP, VIEW LOOKING NORTHWEST, SHOWING THE PLANER WITH ITS BELT CHASE FROM THE BASEMENT LINESHAFT AND THE BELTING SYSTEM FOR THE TABLE-SHAPER. BEYOND THE PLANER IS THE BAND SAW. - Gruber Wagon Works, Pennsylvania Route 183 & State Hill Road at Red Bridge Park, Bernville, Berks County, PA

Chasing vs. Stalking: Interrupting the Perception of Animacy

ERIC Educational Resources Information Center

Gao, Tao; Scholl, Brian J.

2011-01-01

Visual experience involves not only physical features such as color and shape, but also higher-level properties such as animacy and goal-directedness. Perceiving animacy is an inherently dynamic experience, in part because agents' goal-directed behavior may be frequently in flux--unlike many of their physical properties. How does the visual system…

This image, looking due south shows the central part of ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

This image, looking due south shows the central part of the north wing of the building, a 2 story facade. In the foreground are several utility chases which span this elevation of the building - Department of Energy, Mound Facility, Electronics Laboratory Building (E Building), One Mound Road, Miamisburg, Montgomery County, OH

NAEP and Policy: Chasing the Tail of the Assessment Tiger

ERIC Educational Resources Information Center

Diket, Read M.; Brewer, Thomas M.

2011-01-01

This paper grabs hold of the "assessment tiger" by considering the history of the National Assessment of Educational Progress (NAEP) "Arts Report Cards" for the visual arts, which were constructed and have been administered four times within thirty-five years. Two purposes of the NAEP have persisted since its founding: (1)…

My Four Children

ERIC Educational Resources Information Center

Panish, Lisa

2010-01-01

In this article, the author shares how the two service dogs from Canine Assistants helped her realize her goal for her seven-year-old identical twin boys with cerebral palsy to be safer and independent. Connor's dog, Nadia, is a Black Labrador/ Golden Retriever mix. Chase's dog, Oakley, is a Standard Poodle/Golden Retriever mix. Nadia pushes…

Megavolt, Multi-Kiloamp Ka-Band Gyrotron Oscillator Experiment

DTIC Science & Technology

1989-03-15

pulseline accelerator with 20 K2 output impedance and 55 nsec voltage pulse was used to generate a multi-kiloamp annular electron beam by explosive plasma...Lawrence Livermore National Laboratory P.O. Box 808 Livermore, California 94550 Attn: Dr. D. Prosnitz 1 copy Dr. T.J. Orzechowski 1 copy Dr. J. Chase 1

Teachers Make the Best Authors (Could You Be Next?)

ERIC Educational Resources Information Center

Bradbury, Judy

2006-01-01

This article features five classroom teachers who realized their publishing dreams. These teachers include Blue Balliet, author of "Chasing Vermeer" and ""The Wright Three," Patricia Reilly Giff, author of "Today Was a Terrible Day," Lily's Crossing," and "Pictures of Hollis Woods," Vicki Cobb, author of "I Face the Wind," and Science Experiments…

Evaluation of Impinging Stream Vortex Chamber Concepts for Liquid Rocket Engine Applications

NASA Technical Reports Server (NTRS)

Trinh, Huu; Kopicz, Charles; Bullard, Brad; Michaels, Scott

2003-01-01

NASA Marshall Space Flight Center (MSFC) and the U. S. Army are jointly investigating vortex chamber concepts for cryogenic oxygen/hydrocarbon fuel rocket engine applications. One concept, the Impinging Stream Vortex Chamber Concept (ISVC), has been tested with gel propellants at AMCOM at Redstone Arsenal, Alabama. A version of this concept for the liquid oxygen (LOX)/hydrocarbon fuel (RP-1) propellant system is derived from the one for the gel propellant. An unlike impinging injector is employed to deliver the propellants to the chamber. MSFC has also designed two alternative injection schemes, called the chasing injectors, associated with this vortex chamber concept. In these injection techniques, both propellant jets and their impingement point are in the same chamber cross-sectional plane. One injector has a similar orifice size with the original unlike impinging injector. The second chasing injector has small injection orifices. The team has achieved their objectives of demonstrating the self-cooled chamber wall benefits of ISVC and of providing the test data for validating computational fluids dynamics (CFD) models. These models, in turn, will be used to design the optimum vortex chambers in the future.

Costs of locomotion in polar bears: when do the costs outweigh the benefits of chasing down terrestrial prey?

PubMed

Gormezano, Linda J; McWilliams, Scott R; Iles, David T; Rockwell, Robert F

2016-01-01

Trade-offs between locomotory costs and foraging gains are key elements in determining constraints on predator-prey interactions. One intriguing example involves polar bears pursuing snow geese on land. As climate change forces polar bears to spend more time ashore, they may need to expend more energy to obtain land-based food. Given that polar bears are inefficient at terrestrial locomotion, any extra energy expended to pursue prey could negatively impact survival. However, polar bears have been regularly observed engaging in long pursuits of geese and other land animals, and the energetic worth of such behaviour has been repeatedly questioned. We use data-driven energetic models to examine how energy expenditures vary across polar bear mass and speed. For the first time, we show that polar bears in the 125-235 kg size range can profitably pursue geese, especially at slower speeds. We caution, however, that heat build-up may be the ultimate limiting factor in terrestrial chases, especially for larger bears, and this limit would be reached more quickly with warmer environmental temperatures.

Costs of locomotion in polar bears: when do the costs outweigh the benefits of chasing down terrestrial prey?

PubMed Central

Gormezano, Linda J.; McWilliams, Scott R.; Iles, David T.; Rockwell, Robert F.

2016-01-01

Trade-offs between locomotory costs and foraging gains are key elements in determining constraints on predator–prey interactions. One intriguing example involves polar bears pursuing snow geese on land. As climate change forces polar bears to spend more time ashore, they may need to expend more energy to obtain land-based food. Given that polar bears are inefficient at terrestrial locomotion, any extra energy expended to pursue prey could negatively impact survival. However, polar bears have been regularly observed engaging in long pursuits of geese and other land animals, and the energetic worth of such behaviour has been repeatedly questioned. We use data-driven energetic models to examine how energy expenditures vary across polar bear mass and speed. For the first time, we show that polar bears in the 125–235 kg size range can profitably pursue geese, especially at slower speeds. We caution, however, that heat build-up may be the ultimate limiting factor in terrestrial chases, especially for larger bears, and this limit would be reached more quickly with warmer environmental temperatures. PMID:27757238

Project update: evaluating the community health legacy of WWI chemical weapons testing.

PubMed

Fox, Mary A

2014-10-01

The Spring Valley community of Washington, District of Columbia, was built on the site of a World War I chemical weapons lab where testing activities had distributed arsenic to surface soil and waste disposal had resulted in localized subsurface contamination. In previous work, findings were suggestive of potential site-related health issues, although no evidence of cancer clustering was found. In follow-up, we updated the community health assessment and explored time trends for several arsenic-related cancers. Health indicators continue to be very good in Spring Valley. For all major causes of mortality, Spring Valley rates were lower than United States (US) rates with most substantially lower (20-80 %); rates for heart diseases, Alzheimer's, and essential hypertension and related kidney disease were only slightly lower than US rates (3-8 %). Incidence and mortality rates for the selected cancers in the Spring Valley area were lower than US rates. Small non-statistically significant increasing time trends were observed in Spring Valley for incidence of two arsenic-related cancers: bladder and lung and bronchus. A moderate statistically significant increasing rate trend was observed for lung and bronchus cancer mortality in Spring Valley (p < 0.01). Lung and bronchus cancer mortality rates were also increasing in the Chevy Chase community, the local comparison area closely matched to Spring Valley on important demographic variables, suggesting that the observed increases may not be site-related. A full profile of common cancer site rates and trends for both study areas was suggested to better understand the rate trend findings but no epidemiological study was recommended.

Stroller running: Energetic and kinematic changes across pushing methods

PubMed Central

Wall-Scheffler, Cara M.

2017-01-01

Objective Running with a stroller provides an opportunity for parents to exercise near their child and counteract health declines experienced during early parenthood. Understanding biomechanical and physiological changes that occur when stroller running is needed to evaluate its health impact, yet the effects of stroller running have not been clearly presented. Here, three commonly used stroller pushing methods were investigated to detect potential changes in energetic cost and lower-limb kinematics. Methods Sixteen individuals (M/F: 10/6) ran at self-selected speeds for 800m under three stroller conditions (2-Hands, 1-Hand, and Push/Chase) and an independent running control. Results A significant decrease in speed (p = 0.001) and stride length (p<0.001) was observed between the control and stroller conditions, however no significant change in energetic cost (p = 0.080) or heart rate (p = 0.393) was observed. Additionally, pushing method had a significant effect on speed (p = 0.001) and stride length (p<0.001). Conclusions These findings suggest that pushing technique influences stroller running speed and kinematics. These findings suggest specific fitness effects may be achieved through the implementation of different pushing methods. PMID:28672004

Biosynthesis of yeast glycoproteins. Processing of the oligosaccharides transferred from dolichol derivatives.

PubMed

Parodi, A J

1979-10-25

The oligosaccharides previously bound to dolichol diphosphate were isolated from Saccharomyces cerevisiae cells incubated with [U-14C]glucose. Five compounds were obtained that migrated with RGlucose of 0.100, 0.120, 0.145, 0.180, and 0.215 on paper chromatography. All of them contained mannose and 2 N-acetylhexosamine residues. The substances that migrated with the three lower RGlucose values had, in addition, glucose units. The structure of the oligosacchardies was very similar if not identical with that of the oligosaccharides isolated from the dolichol diphosphate derivatives synthesized "in vitro" by yeast or rat liver particulate preparations or "in vivo" by dog thyroid or rat liver slices as judged by their migration on paper chromatography, monosaccharide composition, and degradation compounds produced by alpha-mannosidase treatment or acetolysis. The oligosaccharides previously bound to asparagine residues in proteins were isolated from yeast cells which had been pulsed with [U-14C]glucose and chased with medium containing the unlabeled monosaccharide. The samples taken after very short pulses contained four oligosaccharides that migrated with RGlucose of 0.100, 0.120, 0.145, and 0.180 on paper chromatography. The first three compounds contained glucose, mannose, and 2 N-acetylhexosamine residues whereas the one that migrated with a RGlucose of 0.180 was devoid of the former monosaccharide. Samples taken after short chase periods revealed that the compounds that migrated with the lower RGlucose values gradually disappeared and were converted to the oligosaccharide with the higher RGlucose value was they lost their glucose residues. Similar analysis as those mentioned above showed that the structures of these compounds were similar to those of the dolichol diphosphate-bound oligosaccharides. Samples taken after longer chase periods revealed that the oligosaccharide that migrated with a RGlucose of 0.180 was subsequently either enlarged by the addition of more mannose residues or trimmed to smaller sizes.

Cognitive and physiological markers of emotional awareness in chimpanzees (Pan troglodytes).

PubMed

Parr, L A

2001-11-01

The ability to understand emotion in others is one of the most important factors involved in regulating social interactions in primates. Such emotional awareness functions to coordinate activity among group members, enable the formation of long-lasting individual relationships, and facilitate the pursuit of shared interests. Despite these important evolutionary implications, comparative studies of emotional processing in humans and great apes are practically nonexistent, constituting a major gap in our understanding of the extent to which emotional awareness has played an important role in shaping human behavior and societies. This paper presents the results of two experiments that examine chimpanzees' responses to emotional stimuli. First, changes in peripheral skin temperature were measured while subjects viewed three categories of emotionally negative video scenes; conspecifics being injected with needles (INJ), darts and needles alone (DART), and conspecific directing agonism towards the veterinarians (CHASE). Second, chimpanzees were required to use facial expressions to categorize emotional video scenes, i.e., favorite food and objects and veterinarian procedures, according to their positive and negative valence. With no prior training, subjects spontaneously matched the emotional videos to conspecific facial expressions according to their shared emotional meaning, indicating that chimpanzee facial expressions are processed emotionally, as are human expressions. Decreases in peripheral skin temperature, indicative of negative sympathetic arousal, were significantly lower when subjects viewed the INJ and DART videos, compared to the CHASE videos, indicating greater negative arousal when viewing conspecifics being injected with needles, and needles themselves, than when viewing conspecifics engaged in general agonism.

Supervised retinal vessel segmentation from color fundus images based on matched filtering and AdaBoost classifier.

PubMed

Memari, Nogol; Ramli, Abd Rahman; Bin Saripan, M Iqbal; Mashohor, Syamsiah; Moghbel, Mehrdad

2017-01-01

The structure and appearance of the blood vessel network in retinal fundus images is an essential part of diagnosing various problems associated with the eyes, such as diabetes and hypertension. In this paper, an automatic retinal vessel segmentation method utilizing matched filter techniques coupled with an AdaBoost classifier is proposed. The fundus image is enhanced using morphological operations, the contrast is increased using contrast limited adaptive histogram equalization (CLAHE) method and the inhomogeneity is corrected using Retinex approach. Then, the blood vessels are enhanced using a combination of B-COSFIRE and Frangi matched filters. From this preprocessed image, different statistical features are computed on a pixel-wise basis and used in an AdaBoost classifier to extract the blood vessel network inside the image. Finally, the segmented images are postprocessed to remove the misclassified pixels and regions. The proposed method was validated using publicly accessible Digital Retinal Images for Vessel Extraction (DRIVE), Structured Analysis of the Retina (STARE) and Child Heart and Health Study in England (CHASE_DB1) datasets commonly used for determining the accuracy of retinal vessel segmentation methods. The accuracy of the proposed segmentation method was comparable to other state of the art methods while being very close to the manual segmentation provided by the second human observer with an average accuracy of 0.972, 0.951 and 0.948 in DRIVE, STARE and CHASE_DB1 datasets, respectively.

The use of a high resolution model in a private environment.

NASA Astrophysics Data System (ADS)

van Dijke, D.; Malda, D.

2009-09-01

The commercial organisation MeteoGroup uses high resolution modelling for multiple purposes. MeteoGroup uses the Weather Research and Forecasting Model (WRF®1). WRF is used in the operational environment of several MeteoGroup companies across Europe. It is also used in hindcast studies, for example hurricane tracking, wind climate computation and deriving boundary conditions for air quality models. A special operational service was set up for our tornado chasing team that uses high resolution flexible WRF data to chase for super cells and tornados in the USA during spring. Much effort is put into the development and improvement of the pre- and post-processing of the model. At MeteoGroup the static land-use data has been extended and adjusted to improve temperature and wind forecasts. The system has been modified such that sigma level input data from the global ECMWF model can be used for initialisation. By default only pressure level data could be used. During the spin-up of the model synoptical observations are nudged. A program to adjust possible initialisation errors of several surface parameters in coastal areas has been implemented. We developed an algorithm that computes cloud fractions using multiple direct model output variables. Forecasters prefer to use weather codes for their daily forecasts to detect severe weather. For this usage we developed model weather codes using a variety of direct model output and our own derived variables. 1 WRF® is a registered trademark of the University Corporation for Atmospheric Research (UCAR)

Teachers Unions and the War Within: Making Sense of the Conflict

ERIC Educational Resources Information Center

Antonucci, Mike

2015-01-01

In 1983, after the "A Nation at Risk" report came out, National Education Association (NEA) president Mary Hatwood Futrell attempted to mobilize the teachers union to lead the reform movement in American public education. This author states that Futrell failed at that task, as did Bob Chase, as did his successors, as will future NEA…

Comparative Approaches to Genetic Discrimination: Chasing Shadows?

PubMed

Joly, Yann; Feze, Ida Ngueng; Song, Lingqiao; Knoppers, Bartha M

2017-05-01

Genetic discrimination (GD) is one of the most pervasive issues associated with genetic research and its large-scale implementation. An increasing number of countries have adopted public policies to address this issue. Our research presents a worldwide comparative review and typology of these approaches. We conclude with suggestions for public policy development. Copyright © 2017 Elsevier Ltd. All rights reserved.

We Spent Our Summer Chasing Unicorns: A Young Adult Reading Game Update.

ERIC Educational Resources Information Center

Edgerton, Cathi

1986-01-01

Describes a young adult summer reading game which is offered in three age-level versions from grades 1 through 12 at Enoch Pratt Free Library (Maryland). Benefits of young adult reading games in public libraries, game rules and sample questions, and the game finale visit to Walters Art Gallery are highlighted. (EJS)

Establishment of the Fox Chase Network Breast Cancer Risk Registry.

DTIC Science & Technology

1998-10-01

urologists, pathologists, nurses, health educators, genetic counselors, epidemiologists, behavioral scientists, nutritionists and basic scientists. The...data can readily be translated into a family pedigree for counseling and teaching purposes. Our success in confirming diagnoses with medical records...didactic and interactive teaching covering the following topics: fundamentals of cancer genetics; cancer inheritance patterns; risk assessment and

"The Show"

ERIC Educational Resources Information Center

Gehring, John

2004-01-01

For the past 16 years, the blue-collar city of Huntington, West Virginia, has rolled out the red carpet to welcome young wrestlers and their families as old friends. They have come to town chasing the same dream for a spot in what many of them call "The Show". For three days, under the lights of an arena packed with 5,000 fans, the…

Crash Testing in the Lab: Putting a New Stop to the CO2 Car!

ERIC Educational Resources Information Center

Decker, Rob

2005-01-01

Every year in the United States, the federal government, insurance companies and automobile manufacturers wreck hundreds of cars for safety-testing purposes. All this crashing comes in an effort to rate vehicular safety for the public. Inspired by numerous movies with car chases, dramatic wrecks and television commercials showing car safety tests,…

Achieving Teaching and Learning Excellence with Technology

ERIC Educational Resources Information Center

Marcoux, Elizabeth; Loertscher, David V.

2009-01-01

Since the very first introduction of a Commodore Pet, TRS 80, and the Apple II microcomputers beginning in 1977, billions of dollars have been spent chasing a dream about the effect of technology on teaching and learning. Now, educators face the second decade of the 21st Century with seemingly unlimited ways technology can influence what people…

Status of Research in Teacher Education: Go Ahead, Chase, Cherish or Perish

ERIC Educational Resources Information Center

Gafoor, K. Abdul

2014-01-01

This presentation focuses on the need for invigorating research in teacher education (TE) with focus on problems in it at national and regional levels in India, especially Kerala. Starting with how teacher education in the region has failed to respond to larger societal changes around, it maintains that principal responsibility of reforming TE…

A Model for the Detection of Moving Targets in Visual Clutter Inspired by Insect Physiology

DTIC Science & Technology

2008-07-01

paper: SDW PS DCO. References 1. Wagner H (1986) Flight performance and visual control of flight of the free- flying housefly (Musca domestica L) 3...differences in the chasing behaviour of houseflies (musca). Biol Cybern 32: 239–241. 3. Land MF (1997) Visual acuity in insects. Annu Rev Entomol 42: 147

Robust and Efficient Anti-Phishing Techniques

DTIC Science & Technology

2012-08-27

card Phishing email ............................................................. 11  Figure 3 Architecture of prototype system...retailers, and social networking services such as Fidelity, Twitter, and iTunes , Amazon, Paypal, Ebay, Visa, Facebook, Bank of America, Chase, and...Services 1 13 iTunes Online Retailer 1 14 Other Online Services/Retailer 13 Table 3 Type 1 Legitimate Email Dataset Vendor Type No. of Emails

The Speeding Car Design Challenge

ERIC Educational Resources Information Center

Roman, Harry T.

2009-01-01

All too often, one reads about high-speed police chases in pursuit of stolen cars that result in death and injury to people and innocent bystanders. Isn't there another way to accomplish the apprehension of the thieves that does not put people at such great risk? This article presents a classroom challenge to use technology to remotely shutdown…

Treasure Chase: Mega Gifts Are Down--But Are They out?

ERIC Educational Resources Information Center

Mayer, Caroline E.

2010-01-01

Just a few years ago, the University of Notre Dame averaged about six mega gifts--$10 million or more--a year. Last year, however, the Fighting Irish received only one such donation. "That multimillion donation has become more difficult to obtain," says Lou Nanni, vice president for university relations at the Indiana institution.…

Bringing Culture to Life through Children's Literature: The Mississippi Delta in the 1930's

ERIC Educational Resources Information Center

Hopper, Peggy F.

2011-01-01

After hearing reminisces from her parents about childhood adventures that took place in the 1930's Mississippi Delta, the author, Peggy F. Hopper, decided to document these stores in two children's books, "Peggy Sue and the Pepper Patch" and "The Adventures of Theodore Roosevelt Hollumway Jones and John Hart: Chasing Bandits."…

Fermilab Today

Science.gov Websites

Workshop at LPC 2014 - One West 2 p.m. Particle Astrophysics Seminar (NOTE LOCATION) - WH6NW Speaker: Chris at LPC 2014 - One West 3:30 p.m. Director's Coffee Break - WH2XO 4 p.m. Accelerator Physics and . Magnetrons don't normally allow this kind of control. One solution, Chase realized, is to apply a well-known

The Orbiter 101 "Enterprise" separates from the NASA 747 carrier aircraft

NASA Image and Video Library

1977-10-12

S77-28931 (12 Oct. 1977) --- The Orbiter 101 "Enterprise" separates from the NASA 747 carrier aircraft to begin its first "tailcone-off" unpowered flight over desert and mountains of Southern California. A T-38 chase plane follows in right background. This was the fourth in a series of five piloted free flights. Photo credit: NASA

Computational and Experimental Evaluation of a Complex Inlet Swirl Pattern Generation System (POSTPRINT)

DTIC Science & Technology

2016-08-01

Sanders, Chase A. Nessler, William W. Copenhaver, Michael G. List, and Timothy J. Janczewski Turbomachinery Branch Turbine Engine Division AUGUST...Branch Turbine Engine Division Turbine Engine Division Aerospace Systems Directorate //Signature// ROBERT D. HANCOCK Principal Scientist Turbine ...ORGANIZATION Turbomachinery Branch Turbine Engine Division Air Force Research Laboratory, Aerospace Systems Directorate Wright-Patterson Air Force

E-1152

NASA Image and Video Library

1954-01-17

These people and this equipment supported the flight of the NACA D-558-2 Skyrocket at the High-Speed Flight Station at South Base, Edwards AFB. Note the two Sabre chase planes, the P2B-1S launch aircraft, and the profusion of ground support equipment, including communications, tracking, maintenance, and rescue vehicles. Research pilot A. Scott Crossfield stands in front of the Skyrocket.

44. July 1974. BLACKSMITH SHOP, VIEW LOOKING EAST THROUGH THE ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

44. July 1974. BLACKSMITH SHOP, VIEW LOOKING EAST THROUGH THE DOOR TO THE WOOD SHOP; ON THE LEFT IS THE D. H. POTTS TIRE SHRINKER; TO THE RIGHT OF THE DOOR IS THE BELT CHASE FROM THE BASEMENT LINESHAFT. - Gruber Wagon Works, Pennsylvania Route 183 & State Hill Road at Red Bridge Park, Bernville, Berks County, PA

Confronting Bullying: It Really Can Get Better

ERIC Educational Resources Information Center

Henkin, Roxanne

2012-01-01

In 2010, a number of suicides resulted in part because of bullying and cyberbullying. They include Tyler Clementi, Asher Brown, Seth Walsh, Justin Aaberg, Eric Mohat, Meredith Rezak, Raymond Chase, and Billy Lucas. These students were gay and lesbian and felt that they had no other option than to take their own lives. Research shows that because…

Lead & Manage My School: Conference on School Safety (Chevy Chase, Maryland, October 10, 2006). Transcripts

ERIC Educational Resources Information Center

US Department of Education, 2006

2006-01-01

Secretary of Education Margaret Spellings joined President Bush, Mrs. Bush, and Attorney General Gonzales at a Conference on School Safety on October 10, 2006. Teachers, parents, administrators, law enforcement officials, and other experts discussed best practices and lessons learned about school safety during the conference at the National 4-H…

75 FR 34117 - Notice of Receipt of Requests to Voluntarily Cancel Certain Pesticide Registrations

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-16

... Chase Products Co. PO Box 70 Maywood, IL 60153 499 Whitmire Micro-Gen Research Laboratories, Inc. Agent... Hauppauge, NY 11788 15142 Wide Horizons Co. Inc 18 Huckleberry Lane Greenwich, CT 06831 33176 Amrep, Inc 990..., Michael Dupre 199 Benson Road (2-5) Middlebury, CT 06749 OR910006; CO920001 FMC Corp., Agricultural...

Can U.S. Forces Lean from Mistakes Made by British during First and Second Anglo-Afghan Wars in the 19th Century?

DTIC Science & Technology

2011-04-29

INDIVIDUAL STUDENT AUTHOR AND DO NOT NECESSARILY REPRESENT THE VIEWS OF EITHER THE MARINE COPS COMMAND AND STAFF COLLEGE OR · ANY OTHER GOVERNMENTAL...entered Afghanistan in April1842. This army destroyed small towns, slaughtered livestock, burned crops and chased villagers into the countryside as

On the Road Again: Consumptives Traveling for Health in the American West, 1840-1925

ERIC Educational Resources Information Center

Abrams, Jeanne

2010-01-01

From the first decades of the twentieth century, hundreds of thousands of health seekers, on the advice of their physicians, family members, or popular advertisements, took to the road to "chase the cure" for tuberculosis, the most dreaded disease of the era. Indeed, tuberculosis, also commonly known as consumption or "the White…

A Paper Chase: Technology Helps Library Save Its Collections on Paper.

ERIC Educational Resources Information Center

Dalrymple, Will

1997-01-01

Bookkeeper, a liquid-based mass deacidification technology, may help the Library of Congress win its war against acid damage in its paper collection. The process impregnates books with magnesium oxide particles that both neutralize the acid in paper and leave an alkaline buffer behind. Describes the problem of acidic degradation and the Bookkeeper…

Chasing Dreams and Recognising Realities: Teachers' Responses to ICT

ERIC Educational Resources Information Center

Underwood, Jean; Dillon, Gayle

2011-01-01

The teaching profession's response to the inexorable march of new technology into education has been a focus of research for some 30 years. Linked with the impact of ICT on measurable performance outcomes, teacher attitudes to technology and the impact on pedagogic practice have been central to that research, a research that has often seen…

A Paradigm for Student Learning Outcome Assessment in Information Systems Education: Continuous Improvement or Chasing Rainbows?

ERIC Educational Resources Information Center

Saulnier, Bruce

2014-01-01

A paradigm is presented for student learning outcome assessment in information systems education. Successful deployment of the paradigm is illustrated using the author's home institution. The paradigm is consistent with both the scholarship of teaching and learning and the scholarship of assessment. It is concluded that the deployment of the…

Chasing Rainbows: A Comment on School Choice and the National Football League

ERIC Educational Resources Information Center

Beal, Brent D.; Olson Beal, Heather K.

2013-01-01

In this article, Brent Beal, and Heather Olson Beal respond to comments made about their article: "Rethinking the Market Metaphor: School Choice, the Common Good, and the National Football League," appearing in this issue of the Journal of School Choice. Comments were made by Vitteritti, Houck, Coulson, Bast, and Merrifield. In their…

Two-Generation Programs in the Twenty-First Century

ERIC Educational Resources Information Center

Chase-Lansdale, P. Lindsay; Brooks-Gunn, Jeanne

2014-01-01

Most of the authors in this issue of "Future of Children" focus on a single strategy for helping both adults and children that could become a component of two-generation programs. Lindsay Chase-Lansdale and Jeanne Brooks-Gunn, on the other hand, look at actual programs with an explicit two-generation focus that have been tried in the…

DOE Office of Scientific and Technical Information (OSTI.GOV)

Loehle, C.

This article discusses the problems involved in maintaining creativity in scientific research under the present system of funding through grant reviews. The author recommends funding of investigators for three- to five-year periods based on the individual's track record rather than to fund a detailed proposal. This practice would free the truly productive scientist from grant-chasing and from making overly rigid research plans.

Simulation study of the carbon dioxide enhanced oil recovery pilot test in the Griffithsville Field, Lincoln County, West Virginia

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brummert, A.C.

1990-09-01

A carbon dioxide pilot test was conducted in the Griffithsville Field, Lincoln County, West Virginia, on a 90-acre tract containing nine 10-acre, normal, five-spot patterns arranged in a 3 {times} 3 matrix. This post-flood simulation study evaluates the initial pressure buildup phase of water injection, the carbon dioxide injection phase, and the chase water injection phase. Core data, geophysical well logs, fluid property data, well test data, and injection/production histories were used in setting up the data input record for the reservoir simulator. The reservoir simulator was IMEX, a four-component, black-oil reservoir simulator. 23 refs., 15 figs., 3 tabs.

Distinct developmental genetic mechanisms underlie convergently evolved tooth gain in sticklebacks

PubMed Central

Ellis, Nicholas A.; Glazer, Andrew M.; Donde, Nikunj N.; Cleves, Phillip A.; Agoglia, Rachel M.; Miller, Craig T.

2015-01-01

Teeth are a classic model system of organogenesis, as repeated and reciprocal epithelial and mesenchymal interactions pattern placode formation and outgrowth. Less is known about the developmental and genetic bases of tooth formation and replacement in polyphyodonts, which are vertebrates with continual tooth replacement. Here, we leverage natural variation in the threespine stickleback fish Gasterosteus aculeatus to investigate the genetic basis of tooth development and replacement. We find that two derived freshwater stickleback populations have both convergently evolved more ventral pharyngeal teeth through heritable genetic changes. In both populations, evolved tooth gain manifests late in development. Using pulse-chase vital dye labeling to mark newly forming teeth in adult fish, we find that both high-toothed freshwater populations have accelerated tooth replacement rates relative to low-toothed ancestral marine fish. Despite the similar evolved phenotype of more teeth and an accelerated adult replacement rate, the timing of tooth number divergence and the spatial patterns of newly formed adult teeth are different in the two populations, suggesting distinct developmental mechanisms. Using genome-wide linkage mapping in marine-freshwater F2 genetic crosses, we find that the genetic basis of evolved tooth gain in the two freshwater populations is largely distinct. Together, our results support a model whereby increased tooth number and an accelerated tooth replacement rate have evolved convergently in two independently derived freshwater stickleback populations using largely distinct developmental and genetic mechanisms. PMID:26062935

Cohesin Can Remain Associated with Chromosomes during DNA Replication.

PubMed

Rhodes, James D P; Haarhuis, Judith H I; Grimm, Jonathan B; Rowland, Benjamin D; Lavis, Luke D; Nasmyth, Kim A

2017-09-19

To ensure disjunction to opposite poles during anaphase, sister chromatids must be held together following DNA replication. This is mediated by cohesin, which is thought to entrap sister DNAs inside a tripartite ring composed of its Smc and kleisin (Scc1) subunits. How such structures are created during S phase is poorly understood, in particular whether they are derived from complexes that had entrapped DNAs prior to replication. To address this, we used selective photobleaching to determine whether cohesin associated with chromatin in G1 persists in situ after replication. We developed a non-fluorescent HaloTag ligand to discriminate the fluorescence recovery signal from labeling of newly synthesized Halo-tagged Scc1 protein (pulse-chase or pcFRAP). In cells where cohesin turnover is inactivated by deletion of WAPL, Scc1 can remain associated with chromatin throughout S phase. These findings suggest that cohesion might be generated by cohesin that is already bound to un-replicated DNA. Copyright © 2017 The Author(s). Published by Elsevier Inc. All rights reserved.

Human CD62Ldim neutrophils identified as a separate subset by proteome profiling and in vivo pulse-chase labeling.

PubMed

Tak, Tamar; Wijten, Patrick; Heeres, Marjolein; Pickkers, Peter; Scholten, Arjen; Heck, Albert J R; Vrisekoop, Nienke; Leenen, Luke P; Borghans, José A M; Tesselaar, Kiki; Koenderman, Leo

2017-06-29

During acute inflammation, 3 neutrophil subsets are found in the blood: neutrophils with a conventional segmented nucleus, neutrophils with a banded nucleus, and T-cell-suppressing CD62L dim neutrophils with a high number of nuclear lobes. In this study, we compared the in vivo kinetics and proteomes of banded, mature, and hypersegmented neutrophils to determine whether these cell types represent truly different neutrophil subsets or reflect changes induced by lipopolysaccharide (LPS) activation. Using in vivo pulse-chase labeling of neutrophil DNA with 6,6- 2 H 2 -glucose, we found that 2 H-labeled banded neutrophils appeared much earlier in blood than labeled CD62L dim and segmented neutrophils, which shared similar label kinetics. Comparison of the proteomes by cluster analysis revealed that CD62L dim neutrophils were clearly separate from conventional segmented neutrophils despite having similar kinetics in peripheral blood. Interestingly, the conventional segmented cells were more related at a proteome level to banded cells despite a 2-day difference in maturation time. The differences between CD62L dim and mature neutrophils are unlikely to have been a direct result of LPS-induced activation, because of the extremely low transcriptional capacity of CD62L dim neutrophils and the fact that neutrophils do not directly respond to the low dose of LPS used in the study (2 ng/kg body weight). Therefore, we propose CD62L dim neutrophils are a truly separate neutrophil subset that is recruited to the bloodstream in response to acute inflammation. This trial was registered at www.clinicaltrials.gov as #NCT01766414. © 2017 by The American Society of Hematology.

A photo-cross-linking approach to monitor folding and assembly of newly synthesized proteins in a living cell.

PubMed

Miyazaki, Ryoji; Myougo, Naomi; Mori, Hiroyuki; Akiyama, Yoshinori

2018-01-12

Many proteins form multimeric complexes that play crucial roles in various cellular processes. Studying how proteins are correctly folded and assembled into such complexes in a living cell is important for understanding the physiological roles and the qualitative and quantitative regulation of the complex. However, few methods are suitable for analyzing these rapidly occurring processes. Site-directed in vivo photo-cross-linking is an elegant technique that enables analysis of protein-protein interactions in living cells with high spatial resolution. However, the conventional site-directed in vivo photo-cross-linking method is unsuitable for analyzing dynamic processes. Here, by combining an improved site-directed in vivo photo-cross-linking technique with a pulse-chase approach, we developed a new method that can analyze the folding and assembly of a newly synthesized protein with high spatiotemporal resolution. We demonstrate that this method, named the pulse-chase and in vivo photo-cross-linking experiment (PiXie), enables the kinetic analysis of the formation of an Escherichia coli periplasmic (soluble) protein complex (PhoA). We also used our new technique to investigate assembly/folding processes of two membrane complexes (SecD-SecF in the inner membrane and LptD-LptE in the outer membrane), which provided new insights into the biogenesis of these complexes. Our PiXie method permits analysis of the dynamic behavior of various proteins and enables examination of protein-protein interactions at the level of individual amino acid residues. We anticipate that our new technique will have valuable utility for studies of protein dynamics in many organisms. © 2018 by The American Society for Biochemistry and Molecular Biology, Inc.

Imaging Complex Protein Metabolism in Live Organisms by Stimulated Raman Scattering Microscopy with Isotope Labeling

PubMed Central

2016-01-01

Protein metabolism, consisting of both synthesis and degradation, is highly complex, playing an indispensable regulatory role throughout physiological and pathological processes. Over recent decades, extensive efforts, using approaches such as autoradiography, mass spectrometry, and fluorescence microscopy, have been devoted to the study of protein metabolism. However, noninvasive and global visualization of protein metabolism has proven to be highly challenging, especially in live systems. Recently, stimulated Raman scattering (SRS) microscopy coupled with metabolic labeling of deuterated amino acids (D-AAs) was demonstrated for use in imaging newly synthesized proteins in cultured cell lines. Herein, we significantly generalize this notion to develop a comprehensive labeling and imaging platform for live visualization of complex protein metabolism, including synthesis, degradation, and pulse–chase analysis of two temporally defined populations. First, the deuterium labeling efficiency was optimized, allowing time-lapse imaging of protein synthesis dynamics within individual live cells with high spatial–temporal resolution. Second, by tracking the methyl group (CH3) distribution attributed to pre-existing proteins, this platform also enables us to map protein degradation inside live cells. Third, using two subsets of structurally and spectroscopically distinct D-AAs, we achieved two-color pulse–chase imaging, as demonstrated by observing aggregate formation of mutant hungtingtin proteins. Finally, going beyond simple cell lines, we demonstrated the imaging ability of protein synthesis in brain tissues, zebrafish, and mice in vivo. Hence, the presented labeling and imaging platform would be a valuable tool to study complex protein metabolism with high sensitivity, resolution, and biocompatibility for a broad spectrum of systems ranging from cells to model animals and possibly to humans. PMID:25560305

A comparative study of the response to repeated chasing stress in Atlantic salmon (Salmo salar L.) parr and post-smolts.

PubMed

Madaro, Angelico; Olsen, Rolf Erik; Kristiansen, Tore S; Ebbesson, Lars O E; Flik, Gert; Gorissen, Marnix

2016-02-01

When Atlantic salmon parr migrate from fresh water towards the sea, they undergo extensive morphological, neural, physiological and behavioural changes. Such changes have the potential to affect their responsiveness to various environmental factors that impose stress. In this study we compared the stress responses in parr and post-smolt salmon following exposure to repeated chasing stress (RCS) for three weeks. At the end of this period, all fish were challenged with a novel stressor and sampled before (T0) and after 1h (T1). Parr had a higher growth rate than post-smolts. Plasma cortisol declined in the RCS groups within the first week suggesting a rapid habituation/desensitisation of the endocrine stress axis. As a result of the desensitised HPI axis, RCS groups showed a reduced cortisol response when exposed to the novel stressor. In preoptic area (POA) crf mRNA levels were higher in all post-smolt groups compared to parr. 11βhsd2 decreased by RCS and by the novel stressor in post-smolt controls (T1), whereas no effect of either stress was seen in parr. The grs were low in all groups except for parr controls. In pituitary, parr controls had higher levels of crf1r mRNA than the other parr and post-smolt groups, whilst pomcb was higher in post-smolt control groups. Overall, 11βhsd2 transcript abundance in parr was lower than post-smolt groups; after the novel stressor pomcs, grs and mr were up-regulated in parr control (T1). In summary, we highlight differences in the central stress response between parr and post-smolt salmon following RCS. Copyright © 2015 Elsevier Inc. All rights reserved.

75 FR 47585 - Jonathan and Jayne Chase; Notice of Application Tendered for Filing With the Commission and...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-06

.... e. Name of Project: Troy Hydroelectric Project. f. Location: On the Missisquoi River, in the Town of Troy, Orleans County, Vermont. The project would not occupy lands of the United States. g. Filed... application is not ready for environmental analysis at this time. n. The Troy Project would consist of: (1...

Temperament, Select Home Environment Characteristics and Reading Readiness as Predictors of Reading Progress.

ERIC Educational Resources Information Center

Brown, T.J.

Progress in a primary-grade reading program was determined for 106 first-born, second-grade students at the end of the school year. Previous data available for this sample included Thomas-Chase-Birch temperament ratings, family intactness and socioeconomic status at age four, and Metropolitan Readiness Test scores at age six. The value of these…

Possession, Attraction, and the Thrill of the Chase: Gendered Myth-Making in Film and Television Comedy of the Sexes.

ERIC Educational Resources Information Center

Scodari, Christine

1995-01-01

Examines articulations of "egalitarian" courtship in romantic comedy films of the 1930s and 1940s and recent television series resurrecting their conventions. Gauges the extent to which such texts are open to a negotiated reading that recontextualizes heterosexual monogamy in anarchic rather than patriarchal terms. Suggests that the…

Upside down and inside out: Flip Your Classroom to Improve Student Learning

ERIC Educational Resources Information Center

Fulton, Kathleen

2012-01-01

Educators are notorious for jumping on passing fads and chasing the newest innovations, from the open classrooms of the 1970s to the one-laptop-per-student initiatives of the past decade. It is not surprising that when the next new thing--the flipped classroom--hit the hallways of America's schools, it was met with hesitation and skepticism from…

Swee'Pea and Other Playground Legends: Tales of Drugs, Violence and Basketball.

ERIC Educational Resources Information Center

Valenti, John; Naclerio, Ron

This biography chronicles the life of Lloyd "Swee'pea" Daniels, considered one of the finest basketball players ever to come out of New York City. The book also serves as a sociological expose of the dark side of collegiate and professional sports, in its description of a youngster chasing the dream of playing basketball, but finally…

Chase: Control of Heterogeneous Autonomous Sensors for Situational Awareness

DTIC Science & Technology

2016-08-03

remained the discovery and analysis of new foundational methodology for information collection and fusion that exercises rigorous feedback control over...simultaneously achieve quantified information and physical objectives. New foundational methodology for information collection and fusion that exercises...11.2.1. In the general area of novel stochastic systems analysis it seems appropriate to mention the pioneering work on non -Bayesian distributed learning

View port to starboard of a portion of compartment A126 ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

View port to starboard of a portion of compartment A-126 fitted out to represent a WW I canteen. This may have been location for ship's store where crew could buy tobacco and sundries. Note wood conduit on overhead which served as a chase for wiring. (036) - USS Olympia, Penn's Landing, 211 South Columbus Boulevard, Philadelphia, Philadelphia County, PA

The Marketing Effectiveness of Hotel Facebook Pages: From Perspectives of Customers and Messages

ERIC Educational Resources Information Center

Leung, Xi Yu

2012-01-01

In the hotel industry, social media marketing has become a new trend hoteliers are chasing and an increasing number of hotels are using social media to promote their business. However, the marketing effectiveness of social media is still a big challenge in both academic and business world. Since social media marketing is totally different from…

75 FR 73960 - Safety Zone; “Contagion” Movie Filming, Calumet River, Chicago, IL

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-30

...-AA00 Safety Zone; ``Contagion'' Movie Filming, Calumet River, Chicago, IL AGENCY: Coast Guard, DHS... Calumet River due to the filming of a movie involving high speed boat chases and other dangerous stunts on... movie. DATES: This rule is effective from 7 a.m. on December 11, 2010 until 7 a.m. on December 12, 2010...

Examining dolphin hydrodynamics provides clues to calf-loss during tuna fishing

PubMed Central

Moore, Pete

2004-01-01

A combination of mathematical modeling and direct observation of the swimming behavior of dolphin mother-calf pairs has shown how the calf can gain much of the energy required for swimming if it is positioned correctly relative to the mother, a situation that may be disrupted during the chases that result from tuna-fishing practices. PMID:15132739

Field Flight Dynamics of Hummingbirds during Territory Encroachment and Defense

PubMed Central

Sholtis, Katherine M.; Shelton, Ryan M.; Hedrick, Tyson L.

2015-01-01

Hummingbirds are known to defend food resources such as nectar sources from encroachment by competitors (including conspecifics). These competitive intraspecific interactions provide an opportunity to quantify the biomechanics of hummingbird flight performance during ecologically relevant natural behavior. We recorded the three-dimensional flight trajectories of Ruby-throated Hummingbirds defending, being chased from and freely departing from a feeder. These trajectories allowed us to compare natural flight performance to earlier laboratory measurements of maximum flight speed, aerodynamic force generation and power estimates. During field observation, hummingbirds rarely approached the maximal flight speeds previously reported from wind tunnel tests and never did so during level flight. However, the accelerations and rates of change in kinetic and potential energy we recorded indicate that these hummingbirds likely operated near the maximum of their flight force and metabolic power capabilities during these competitive interactions. Furthermore, although birds departing from the feeder while chased did so faster than freely-departing birds, these speed gains were accomplished by modulating kinetic and potential energy gains (or losses) rather than increasing overall power output, essentially trading altitude for speed during their evasive maneuver. Finally, the trajectories of defending birds were directed toward the position of the encroaching bird rather than the feeder. PMID:26039101

The Nudix Hydrolase CDP-Chase, a CDP-Choline Pyrophosphatase, Is an Asymmetric Dimer with Two Distinct Enzymatic Activities

DOE Office of Scientific and Technical Information (OSTI.GOV)

Duong-Ly, Krisna C.; Gabelli, Sandra B.; Xu, WenLian

2011-09-06

A Nudix enzyme from Bacillus cereus catalyzes the hydrolysis of CDP-choline to produce CMP and phosphocholine. Here, we show that in addition, the enzyme has a 3{prime} {yields} 5{prime} RNA exonuclease activity. The structure of the free enzyme, determined to a 1.8-{angstrom} resolution, shows that the enzyme is an asymmetric dimer. Each monomer consists of two domains, an N-terminal helical domain and a C-terminal Nudix domain. The N-terminal domain is placed relative to the C-terminal domain such as to result in an overall asymmetric arrangement with two distinct catalytic sites: one with an 'enclosed' Nudix pyrophosphatase site and the othermore » with a more open, less-defined cavity. Residues that may be important for determining the asymmetry are conserved among a group of uncharacterized Nudix enzymes from Gram-positive bacteria. Our data support a model where CDP-choline hydrolysis is catalyzed by the enclosed Nudix site and RNA exonuclease activity is catalyzed by the open site. CDP-Chase is the first identified member of a novel Nudix family in which structural asymmetry has a profound effect on the recognition of substrates.« less

Delayed response and biosonar perception explain movement coordination in trawling bats.

PubMed

Giuggioli, Luca; McKetterick, Thomas J; Holderied, Marc

2015-03-01

Animal coordinated movement interactions are commonly explained by assuming unspecified social forces of attraction, repulsion and alignment with parameters drawn from observed movement data. Here we propose and test a biologically realistic and quantifiable biosonar movement interaction mechanism for echolocating bats based on spatial perceptual bias, i.e. actual sound field, a reaction delay, and observed motor constraints in speed and acceleration. We found that foraging pairs of bats flying over a water surface swapped leader-follower roles and performed chases or coordinated manoeuvres by copying the heading a nearby individual has had up to 500 ms earlier. Our proposed mechanism based on the interplay between sensory-motor constraints and delayed alignment was able to recreate the observed spatial actor-reactor patterns. Remarkably, when we varied model parameters (response delay, hearing threshold and echolocation directionality) beyond those observed in nature, the spatio-temporal interaction patterns created by the model only recreated the observed interactions, i.e. chases, and best matched the observed spatial patterns for just those response delays, hearing thresholds and echolocation directionalities found to be used by bats. This supports the validity of our sensory ecology approach of movement coordination, where interacting bats localise each other by active echolocation rather than eavesdropping.

Field Flight Dynamics of Hummingbirds during Territory Encroachment and Defense.

PubMed

Sholtis, Katherine M; Shelton, Ryan M; Hedrick, Tyson L

2015-01-01

Hummingbirds are known to defend food resources such as nectar sources from encroachment by competitors (including conspecifics). These competitive intraspecific interactions provide an opportunity to quantify the biomechanics of hummingbird flight performance during ecologically relevant natural behavior. We recorded the three-dimensional flight trajectories of Ruby-throated Hummingbirds defending, being chased from and freely departing from a feeder. These trajectories allowed us to compare natural flight performance to earlier laboratory measurements of maximum flight speed, aerodynamic force generation and power estimates. During field observation, hummingbirds rarely approached the maximal flight speeds previously reported from wind tunnel tests and never did so during level flight. However, the accelerations and rates of change in kinetic and potential energy we recorded indicate that these hummingbirds likely operated near the maximum of their flight force and metabolic power capabilities during these competitive interactions. Furthermore, although birds departing from the feeder while chased did so faster than freely-departing birds, these speed gains were accomplished by modulating kinetic and potential energy gains (or losses) rather than increasing overall power output, essentially trading altitude for speed during their evasive maneuver. Finally, the trajectories of defending birds were directed toward the position of the encroaching bird rather than the feeder.

Tiger beetles pursue prey using a proportional control law with a delay of one half-stride.

PubMed

Haselsteiner, Andreas F; Gilbert, Cole; Wang, Z Jane

2014-06-06

Tiger beetles are fast diurnal predators capable of chasing prey under closed-loop visual guidance. We investigated this control system using statistical analyses of high-speed digital recordings of beetles chasing a moving prey dummy in a laboratory arena. Correlation analyses reveal that the beetle uses a proportional control law in which the angular position of the prey relative to the beetle's body axis drives the beetle's angular velocity with a delay of about 28 ms. The proportionality coefficient or system gain, 12 s(-1), is just below critical damping. Pursuit simulations using the derived control law predict angular orientation during pursuits with a residual error of about 7°. This is of the same order of magnitude as the oscillation imposed by the beetle's alternating tripod gait, which was not factored into the control law. The system delay of 28 ms equals a half-stride period, i.e. the time between the touch down of alternating tripods. Based on these results, we propose a physical interpretation of the observed control law: to turn towards its prey, the beetle on average exerts a sideways force proportional to the angular position of the prey measured a half-stride earlier.

Interest in genomic SNP testing for prostate cancer risk: a pilot survey.

PubMed

Hall, Michael J; Ruth, Karen J; Chen, David Yt; Gross, Laura M; Giri, Veda N

2015-01-01

Advancements in genomic testing have led to the identification of single nucleotide polymorphisms (SNPs) associated with prostate cancer. The clinical utility of SNP tests to evaluate prostate cancer risk is unclear. Studies have not examined predictors of interest in novel genomic SNP tests for prostate cancer risk in a diverse population. Consecutive participants in the Fox Chase Prostate Cancer Risk Assessment Program (PRAP) (n = 40) and unselected men from surgical urology clinics (n = 40) completed a one-time survey. Items examined interest in genomic SNP testing for prostate cancer risk, knowledge, impact of unsolicited findings, and psychosocial factors including health literacy. Knowledge of genomic SNP tests was low in both groups, but interest was higher among PRAP men (p < 0.001). The prospect of receiving unsolicited results about ancestral genomic markers increased interest in testing in both groups. Multivariable modeling identified several predictors of higher interest in a genomic SNP test including higher perceived risk (p = 0.025), indicating zero reasons for not wanting testing (vs ≥1 reason) (p = 0.013), and higher health literacy (p = 0.016). Knowledge of genomic SNP testing was low in this sample, but higher among high-risk men. High-risk status may increase interest in novel genomic tests, while low literacy may lessen interest.

Diel spawning behavior of chum salmon in the Columbia River

USGS Publications Warehouse

Tiffan, K.F.; Rondorf, D.W.; Skalicky, J.J.

2005-01-01

We conducted a study during 2003 in a side channel of the Columbia River downstream of Bonneville Dam to describe the diel spawning behavior of wild chum salmon Oncorhynchus keta. We collected observational data on 14 pairs of chum salmon using a dual-frequency identification sonar. Spawners of both genders were observed chasing intruders during nighttime and daytime as nests were constructed. Regardless of diel period, females were engaged in digging to both construct nests and cover eggs, and courting males exhibited the prespawning behavior of tail-crossing. We observed a total of 13 spawning events, of which 9 occurred at night and 4 occurred during the day. Once chum salmon begin nest construction, visual cues are apparently not required for courtship, nest defense, and spawning. To enhance successful spawning, flows from Bonneville Dam during the spawning season were reduced during the day but were sometimes increased at night to pass water and meet power demand (i.e., reverse loading), the assumption being that chum salmon are inactive at night. Our findings show that this assumption was violated. Therefore, reverse loading may disrupt the complex prespawning behavior that occurs both during the day and at night, as well as attract spawners to areas that were dewatered during the day.

Internet Medline providers.

PubMed

Vine, D L; Coady, T R

1998-01-01

Each database in this review has features that will appeal to some users. Each provides a credible interface to information available within the Medline database. The major differences are pricing and interface design. In this context, features that cost more and might seem trivial to the occasional searcher may actually save time and money when used by the professional. Internet Grateful Med is free, but Ms. Coady and I agree the availability of only three ANDable search fields is a major functional limitation. PubMed is also free but much more powerful. The command line interface that permits very sophisticated searches requires a commitment that casual users will find intimidating. Ms. Coady did not believe the feedback currently provided during a search was sufficient for sustained professional use. Paper Chase and Knowledge Finder are mature, modestly priced Medline search services. Paper Chase provides a menu-driven interface that is very easy to use, yet permits the user to search virtually all of Medline's data fields. Knowledge Finder emphasizes the use of natural language queries but fully supports more traditional search strategies. The impact of the tradeoff between fuzzy and Boolean strategies offered by Knowledge Finder is unclear and beyond the scope of this review. Additional software must be downloaded to use all of Knowledge Finders' features. Other providers required no software beyond the basic Internet browser, and this requirement prevented Ms. Coady from evaluating Knowledge Finder. Ovid and Silver Platter offer well-designed interfaces that simplify the construction of complex queries. These are clearly services designed for professional users. While pricing eliminates these for casual use, it should be emphasized that Medline citation access is only a portion of the service provided by these high-end vendors. Finally, we should comment that each of the vendors and government-sponsored services provided prompt and useful feedback to e-mail questions about usage. In conclusion, we would suggest you try the various services, determine which interface suits your style and budget, then perform simple searches until you learn the strengths and weaknesses of the service you select.

Child's Letter to President John F. Kennedy about Physical Fitness

ERIC Educational Resources Information Center

McNatt, Missy

2009-01-01

On March 3, 1963, nine-year-old Jack Chase of Torrance, California, wrote a letter to President John F. Kennedy. In his single-page note, featured in this article, Jack described his plans for staying physically fit. He said he would walk to school, the store, and the library "because I know a strong boy makes a strong man and a strong man makes a…

2011 Naval Energy Forum. Volume 2

DTIC Science & Technology

2011-10-14

APPLIED RESEARCH ASSOCIATES • CHASE SUPPLY, INC. • ESPEY MGF. & ELECTRONICS • FREE FLOW POWER • LIVEFUELS • MILSPRAY MILITARY TECHNOLOGIES • PETRA ... Martin Luther King experts reality check? 5 “Heavier-than-air flying machines are impossible” - Lord Kelvin, President, Royal Society, 1895 6 “The...1. Win-Win: Mutual Benefit & Value Proposition – DOD: Save Energy, Save Money, Save Lives (General Martin Dempsey) – DOE: Accelerate technology

A Legacy of Sacrifice and Honor: Celebrating Tribal Resilience and Military Service at Haskell Nations University

ERIC Educational Resources Information Center

Warrington, Jacinta

2017-01-01

Haskell Indian Nations University opened 133 years ago, on September 17, 1884, as the U.S. Training and Industrial School--one of three original tribal boarding schools funded by the United States Congress. Three years later the school changed its name to Haskell Institute in honor of Chase Dudley Haskell, a U.S. representative from the Second…

Chasing Down Gravitational Wave Sources with the Dark Energy Camera

DOE Office of Scientific and Technical Information (OSTI.GOV)

Annis, Jim; Soares-Santos, Marcelle

On August 17, 2017, scientists using the Dark Energy Camera tracked down the first visible counterpart to a gravitational wave signal ever spotted by astronomers. Using data provided by the LIGO and Virgo collaborations, scientists embarked on a quest for the unknown, and discovered a new wonder of the universe. Includes interviews with Fermilab’s Jim Annis and Brandeis University’s Marcelle Soares-Santos.