Geographic information system (GIS) simulation of emergency power production from disaster debris in a combined heat and power (CHP) system

NASA Astrophysics Data System (ADS)

Ryals, Christopher Shannon

The objective of this study is to determine a predicted energy capacity of disaster debris for the production of emergency power using a combined heat and power (CHP) unit. A prediction simulation using geographic information systems (GIS) will use data from past storms to calculate an estimated amount of debris along with an estimated energy potential of said debris. Rather than the expense and burden of transporting woody debris such as downed trees and wood framing materials offsite, they can be processed (sorting and chipping) to provide an onsite energy source to provide power to emergency management facilities such as shelters in schools and hospitals. A CHP unit can simultaneously produce heat, cooling effects and electrical power using various biomass sources. This study surveys the quantity and composition of debris produced for a given classification of disaster and location. A comparison of power efficiency estimates for various disasters is conducted.

Methods for Analysis of Urban Energy Systems: A New York City Case Study

NASA Astrophysics Data System (ADS)

Howard, Bianca

This dissertation describes methods developed for analysis of the New York City energy system. The analysis specifically aims to consider the built environment and its' impacts on greenhouse gas (GHG) emissions. Several contributions to the urban energy systems literature were made. First, estimates of annual energy intensities of the New York building stock were derived using a statistical analysis that leveraged energy consumption and tax assessor data collected by the Office of the Mayor. These estimates provided the basis for an assessment of the spatial distribution of building energy consumption. The energy consumption estimates were then leveraged to estimate the potential for combined heat and power (CHP) systems in New York City at both the building and microgrid scales. In aggregate, given the 2009 non-baseload GHG emissions factors for electricity production, these systems could reduce citywide GHG emissions by 10%. The operational characteristics of CHP systems were explored further considering different prime movers, climates, and GHG emissions factors. A combination of mixed integer linear programing and controlled random search algorithms were the methods used to determine the optimal capacity and operating strategies for the CHP systems under the various scenarios. Lastly a multi-regional unit commitment model of electricity and GHG emissions production for New York State was developed using data collected from several publicly available sources. The model was used to estimate average and marginal GHG emissions factors for New York State and New York City. The analysis found that marginal GHG emissions factors could reduce by 30% to 370 g CO2e/kWh in the next 10 years.

Combined heat and power systems for commercial buildings: investigating cost, emissions, and primary energy reduction based on system components

NASA Astrophysics Data System (ADS)

Smith, Amanda D.

Combined heat and power (CHP) systems produce electricity and useful heat from fuel. When power is produced near a building which consumes power, transmission losses are averted, and heat which is a byproduct of power production may be useful to the building. That thermal energy can be used for hot water or space heating, among other applications. This dissertation focuses on CHP systems using natural gas, a common fuel, and systems serving commercial buildings in the United States. First, the necessary price difference between purchased electricity and purchased fuel is analyzed in terms of the efficiencies of system components by comparing CHP with a conventional separate heat and power (SHP) configuration, where power is purchased from the electrical grid and heat is provided by a gas boiler. Similarly, the relationship between CDE due to electricity purchases and due to fuel purchases is analyzed as well as the relationship between primary energy conversion factors for electricity and fuel. The primary energy conversion factor indicates the quantity of source energy necessary to produce the energy purchased at the site. Next, greenhouse gas emissions are investigated for a variety of commercial buildings using CHP or SHP. The relationship between the magnitude of the reduction in emissions and the parameters of the CHP system is explored. The cost savings and reduction in primary energy consumption are evaluated for the same buildings. Finally, a CHP system is analyzed with the addition of a thermal energy storage (TES) component, which can store excess thermal energy and deliver it later if necessary. The potential for CHP with TES to reduce cost, emissions, and primary energy consumption is investigated for a variety of buildings. A case study is developed for one building for which TES does provide additional benefits over a CHP system alone, and the requirements for a water tank TES device are examined.

Environmental implications of carbon limits on market ...

EPA Pesticide Factsheets

Combined heat and power (CHP) is promoted as an economical, energy-efficient option for combating climate change. To fully examine the viability of CHP as a clean-technology solution, its market potential and impacts need to be analyzed as part of scenarios of the future energy system, particularly those with policies limiting greenhouse gas (GHG) emissions. This paper develops and analyzes scenarios using a bottom-up, technology rich optimization model of the U.S. energy system. Two distinct carbon reduction goals were set up for analysis. In Target 1, carbon emission reduction goals were only included for the electric sector. In Target 2, carbon emission reduction goals were set across the entire energy system with the target patterned after the U.S.’s commitment to reducing GHG emissions as part of the Paris Agreement reached at the COP21 summit. From a system-wide carbon reduction standpoint, Target 2 is significantly more stringent. In addition, these scenarios examine the implications of various CHP capacity expansion and contraction assumptions and energy prices. The largest CHP capacity expansion are observed in scenarios that included Target 1, but investments were scaled back in scenarios that incorporated Target 2. The latter scenario spurred rapid development of zero-emissions technologies within the electric sector, and purchased electricity increased dramatically in many end-use sectors. The results suggest that CHP may play a role in a carbon-c

Ultra Clean 1.1MW High Efficiency Natural Gas Engine Powered System

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zurlo, James; Lueck, Steve

Dresser, Inc. (GE Energy, Waukesha gas engines) will develop, test, demonstrate, and commercialize a 1.1 Megawatt (MW) natural gas fueled combined heat and power reciprocating engine powered package. This package will feature a total efficiency > 75% and ultra low CARB permitting emissions. Our modular design will cover the 1 – 6 MW size range, and this scalable technology can be used in both smaller and larger engine powered CHP packages. To further advance one of the key advantages of reciprocating engines, the engine, generator and CHP package will be optimized for low initial and operating costs. Dresser, Inc. willmore » leverage the knowledge gained in the DOE - ARES program. Dresser, Inc. will work with commercial, regulatory, and government entities to help break down barriers to wider deployment of CHP. The outcome of this project will be a commercially successful 1.1 MW CHP package with high electrical and total efficiency that will significantly reduce emissions compared to the current central power plant paradigm. Principal objectives by phases for Budget Period 1 include: • Phase 1 – market study to determine optimum system performance, target first cost, lifecycle cost, and creation of a detailed product specification. • Phase 2 – Refinement of the Waukesha CHP system design concepts, identification of critical characteristics, initial evaluation of technical solutions, and risk mitigation plans. Background« less

Demonstration of a residential CHP system based on PEM fuel cells

NASA Astrophysics Data System (ADS)

Gigliucci, G.; Petruzzi, L.; Cerelli, E.; Garzisi, A.; La Mendola, A.

Fuel cell-based CHP systems are very attractive for stationary energy generation, since they allow production of electricity and heat in a decentralised, quiet, efficient and environmentally friendly way. As a means of evaluating this new technology, Enel Produzione installed a beta-version fuel cell CHP system, supplied by H-Power, at its experimental area sited in Livorno (Italy), and submitted it to a series of tests. The system is a co-generative unit, converting natural gas into electricity and heat: the former is delivered to local loads using electric load following capability; the latter is delivered to the experimental area hydraulic refrigeration circuit. Experiments were aimed at assessing the suitability of this kind of system to supply Italian residential customers. Factors such as performances, flexibility and operational requirements were evaluated under all the possible operating conditions, both under grid connected and stand alone configurations. At the same time, a mathematical model of the FC/CHP unit was developed to allow for the prediction of system performances and operating parameters under off-design conditions. This model can be used as an effective tool to optimise system operation when a particular customer has to be supplied. Results show that the prototype behaved as expected by a first "proof of concept" system and outline improvements to be achieved in order to satisfy the energy needs of small residential applications.

Optimisation of Combined Cycle Gas Turbine Power Plant in Intraday Market: Riga CHP-2 Example

NASA Astrophysics Data System (ADS)

Ivanova, P.; Grebesh, E.; Linkevics, O.

2018-02-01

In the research, the influence of optimised combined cycle gas turbine unit - according to the previously developed EM & OM approach with its use in the intraday market - is evaluated on the generation portfolio. It consists of the two combined cycle gas turbine units. The introduced evaluation algorithm saves the power and heat balance before and after the performance of EM & OM approach by making changes in the generation profile of units. The aim of this algorithm is profit maximisation of the generation portfolio. The evaluation algorithm is implemented in multi-paradigm numerical computing environment MATLab on the example of Riga CHP-2. The results show that the use of EM & OM approach in the intraday market can be profitable or unprofitable. It depends on the initial state of generation units in the intraday market and on the content of the generation portfolio.

Business Case for a Micro-Combined Heat and Power Fuel Cell System in Commercial Applications

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brooks, Kriston P.; Makhmalbaf, Atefe; Anderson, David M.

2013-10-30

Combined heat and power fuel cell systems (CHP-FCSs) provide consistent electrical power and hot water with greater efficiency and lower emissions than alternative sources. These systems can be used either as baseload, grid-connected, or as off-the-grid power sources. This report presents a business case for CHP-FCSs in the range of 5 to 50 kWe. Systems in this power range are considered micro-CHP-FCS. For this particular business case, commercial applications rather than residential or industrial are targeted. To understand the benefits of implementing a micro-CHP-FCS, the characteristics that determine their competitive advantage must first be identified. Locations with high electricity pricesmore » and low natural gas prices are ideal locations for micro-CHP-FCSs. Fortunately, these high spark spread locations are generally in the northeastern area of the United States and California where government incentives are already in place to offset the current high cost of the micro-CHP-FCSs. As a result of the inherently high efficiency of a fuel cell and their ability to use the waste heat that is generated as a CHP, they have higher efficiency. This results in lower fuel costs than comparable alternative small-scale power systems (e.g., microturbines and reciprocating engines). A variety of markets should consider micro-CHP-FCSs including those that require both heat and baseload electricity throughout the year. In addition, the reliable power of micro-CHP-FCSs could be beneficial to markets where electrical outages are especially frequent or costly. Greenhouse gas emission levels from micro-CHP-FCSs are 69 percent lower, and the human health costs are 99.9 percent lower, than those attributed to conventional coal-fired power plants. As a result, FCSs can allow a company to advertise as environmentally conscious and provide a bottom-line sales advantage. As a new technology in the early stages of adoption, micro-CHP-FCSs are currently more expensive than alternative technologies. As the technology gains a foothold in its target markets and demand increases, the costs will decline in response to improved manufacturing efficiencies, similar to trends seen with other technologies. Transparency Market Research forecasts suggest that the CHP-FCS market will grow at a compound annual growth rate of greater than 27 percent over the next 5 years. These production level increases, coupled with the expected low price of natural gas, indicate the economic payback period will move to less than 5 years over the course of the next 5 years. To better understand the benefits of micro-CHP-FCSs, The U.S. Department of Energy worked with ClearEdge Power to install fifteen 5-kWe fuel cells in the commercial markets of California and Oregon. Pacific Northwest National Laboratory is evaluating these systems in terms of economics, operations, and their environmental impact in real-world applications. As expected, the economic analysis has indicated that the high capital cost of the micro-CHP-FCSs results in a longer payback period than typically is acceptable for all but early-adopter market segments. However, a payback period of less than 3 years may be expected as increased production brings system cost down, and CHP incentives are maintained or improved.« less

System effects of primary energy reduction connected with operation of the CHP plants

NASA Astrophysics Data System (ADS)

Ziębik, Andrzej; Gładysz, Paweł

2017-06-01

The paper is devoted to explication of one of the advantages of heat and electricity cogeneration, rarely considered in technical literature. Usually attention is paid to the fact that heat losses of the heat distribution network are less severe in the case of cogeneration of heat in comparison with its separate production. But this conclusion is also true in other cases when the internal consumption of heat is significant. In this paper it has been proved in the case of two examples concerning trigeneration technology with an absorption chiller cooperating with a combined heat and power (CHP) plant and CHP plant integrated with amine post-combustion CO2 processing unit. In both considered cases it might be said that thanks to cogeneration we have to do with less severe consequences of significant demand of heat for internal purposes.

Combined Heat and Power Market Potential for Opportunity Fuels

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jones, David; Lemar, Paul

This report estimates the potential for opportunity fuel combined heat and power (CHP) applications in the United States, and provides estimates for the technical and economic market potential compared to those included in an earlier report. An opportunity fuel is any type of fuel that is not widely used when compared to traditional fossil fuels. Opportunity fuels primarily consist of biomass fuels, industrial waste products and fossil fuel derivatives. These fuels have the potential to be an economically viable source of power generation in various CHP applications.

Modelling and control synthesis of a micro-combined heat and power interface for a concentrating solar power system in off-grid rural power applications

NASA Astrophysics Data System (ADS)

Prinsloo, Gerro; Dobson, Robert; Brent, Alan; Mammoli, Andrea

2016-05-01

Concentrating solar power co-generation systems have been identified as potential stand-alone solar energy supply solutions in remote rural energy applications. This study describes the modelling and synthesis of a combined heat and power Stirling CSP system in order to evaluate its potential performance in small off-grid rural village applications in Africa. This Stirling micro-Combined Heat and Power (micro-CHP) system has a 1 kW electric capacity, with 3 kW of thermal generation capacity which is produced as waste heat recovered from the solar power generation process. As part of the development of an intelligent microgrid control and distribution solution, the Trinum micro-CHP system and other co-generation systems are systematically being modelled on the TRNSYS simulation platform. This paper describes the modelling and simulation of the Trinum micro-CHP configuration on TRNSYS as part of the process to develop the control automation solution for the smart rural microgrid in which the Trinum will serve as a solar powerpack. The results present simulated performance outputs for the Trinum micro-CHP system for a number of remote rural locations in Africa computed from real-time TRNSYS solar irradiation and weather data (yearly, monthly, daily) for the relevant locations. The focus of this paper is on the parametric modelling of the Trinum Stirling micro-CHP system, with specific reference to this system as a TRNSYS functional block in the microgrid simulation. The model is used to forecast the solar energy harvesting potential of the Trinum micro-CHP unit at a number of remote rural sites in Africa.

Dynamic modeling and evaluation of solid oxide fuel cell - combined heat and power system operating strategies

NASA Astrophysics Data System (ADS)

Nanaeda, Kimihiro; Mueller, Fabian; Brouwer, Jacob; Samuelsen, Scott

Operating strategies of solid oxide fuel cell (SOFC) combined heat and power (CHP) systems are developed and evaluated from a utility, and end-user perspective using a fully integrated SOFC-CHP system dynamic model that resolves the physical states, thermal integration and overall efficiency of the system. The model can be modified for any SOFC-CHP system, but the present analysis is applied to a hotel in southern California based on measured electric and heating loads. Analysis indicates that combined heat and power systems can be operated to benefit both the end-users and the utility, providing more efficient electric generation as well as grid ancillary services, namely dispatchable urban power. Design and operating strategies considered in the paper include optimal sizing of the fuel cell, thermal energy storage to dispatch heat, and operating the fuel cell to provide flexible grid power. Analysis results indicate that with a 13.1% average increase in price-of-electricity (POE), the system can provide the grid with a 50% operating range of dispatchable urban power at an overall thermal efficiency of 80%. This grid-support operating mode increases the operational flexibility of the SOFC-CHP system, which may make the technology an important utility asset for accommodating the increased penetration of intermittent renewable power.

Advanced CHP Control Algorithms: Scope Specification

DOE Office of Scientific and Technical Information (OSTI.GOV)

Katipamula, Srinivas; Brambley, Michael R.

2006-04-28

The primary objective of this multiyear project is to develop algorithms for combined heat and power systems to ensure optimal performance, increase reliability, and lead to the goal of clean, efficient, reliable and affordable next generation energy systems.

Research on Power System Scheduling Improving Wind Power Accommodation Considering Thermal Energy Storage and Flexible Load

NASA Astrophysics Data System (ADS)

Zou, Chenlu; Cui, Xue; Wang, Heng; Zhou, Bin; Liu, Yang

2018-01-01

In the case of rapid development of wind power and heavy wind curtailment, the study of wind power accommodation of combined heat and power system has become the focus of attention. A two-stage scheduling model contains of wind power, thermal energy storage, CHP unit and flexible load were constructed. This model with the objective function of minimizing wind curtailment and the operation cost of units while taking into account of the total coal consumption of units, constraint of thermal energy storage and electricity-heat characteristic of CHP. This paper uses MICA to solve the problem of too many constraints and make the solution more feasible. A numerical example showed that the two stage decision scheduling model can consume more wind power, and it could provide a reference for combined heat and power system short-term operation

CHP Project Development

EPA Pesticide Factsheets

Access information and tools to support the CHP project development process, including identifying if your facility is a good fit for CHP, the steps involved with CHP project development, and policies and incentives supportive of CHP.

Combined heat and power supply using Carnot engines

NASA Astrophysics Data System (ADS)

Horlock, J. H.

The Marshall Report on the thermodynamic and economic feasibility of introducing large scale combined heat and electrical power generation (CHP) into the United Kingdom is summarized. Combinations of reversible power plant (Carnot engines) to meet a given demand of power and heat production are analyzed. The Marshall Report states that fairly large scale CHP plants are an attractive energy saving option for areas of high heat load densities. Analysis shows that for given requirements, the total heat supply and utilization factor are functions of heat output, reservoir supply temperature, temperature of heat rejected to the reservoir, and an intermediate temperature for district heating.

Discover CHP

EPA Pesticide Factsheets

Access information about how CHP systems work; their efficiency, environmental, economic, and reliability benefits; the cost and performance characteristics of CHP technologies; and how to calculate CHP efficiency emissions savings.

CHP Technologies

EPA Pesticide Factsheets

Learn about CHP technologies, including reciprocating engines, combustion turbines, steam turbines, microturbines, fuel cells, and waste heat to power. Access the Catalog of CHP Technologies and the Biomass CHP Catalog of Technologies.

Putative Serine Protease Effectors of Clavibacter michiganensis Induce a Hypersensitive Response in the Apoplast of Nicotiana Species.

PubMed

Lu, You; Hatsugai, Noriyuki; Katagiri, Fumiaki; Ishimaru, Carol A; Glazebrook, Jane

2015-11-01

Clavibacter michiganensis subspp. michiganensis and sepedonicus cause diseases on solanaceous crops. The genomes of both subspecies encode members of the pat-1 family of putative serine proteases known to function in virulence on host plants and induction of hypersensitive responses (HR) on nonhosts. One gene of this family in C. michiganensis subsp. sepedonicus, chp-7, is required for triggering HR in Nicotiana tabacum. Here, further investigation revealed that mutation of the putative catalytic serine residue at position 232 to threonine abolished the HR induction activity of Chp-7, suggesting that enzymatic activity is required. Purified Chp-7 triggered an HR in N. tabacum leaves in the absence of the pathogen, indicating Chp-7 itself is the HR elicitor from C. michiganensis subsp. sepedonicus. Ectopic expression of chp-7 constructs in N. tabacum leaves revealed that Chp-7 targeted to the apoplast triggered an HR while cytoplasmic Chp-7 did not, indicating that Chp-7 induces the HR in the apoplast of N. tabacum leaves. Chp-7 also induced HR in N. sylvestris, a progenitor of N. tabacum, but not in other Nicotiana species tested. ChpG, a related protein from C. michiganensis subsp. michiganensis, also triggered HR in N. tabacum and N. sylvestris. Unlike Chp-7, ChpG triggered HR in N. clevelandii and N. glutinosa.

Research in support of health systems transformation in South Africa: the experience of the Centre for Health Policy.

PubMed

Rispel, Laetitia C; Doherty, Jane

2011-01-01

We describe the role and experience of the Centre for Health Policy (CHP), a university-based research unit established in 1987, in influencing and supporting health systems transformation in South Africa over two decades. During 2010, we analyzed relevant documents and conducted interviews with 25 key informants. CHP's research has contributed directly to health policy development and implementation while also changing the way government understood or approached policy issues. Key success factors for policy influence are: research quality and trustworthiness, strategic alliances and networking, and capacity building. CHP's challenges include identifying new funding sources and sustaining a high public profile. The lessons for other countries are to: conduct good quality, relevant research based on strong ethical values; build and maintain open and honest relationships with government; recognize and adapt to changes in the policy environment; develop capacity as part of a continuous programme; and seek core funding that ensures research independence and public accountability.

Benefits of CHP Partnership

EPA Pesticide Factsheets

Learn about the benefits of being a EPA CHP Partner, which include expert advice and answers to questions, CHP news, marketing resources, publicity and recognition, and being associated with EPA through a demonstrated commitment to CHP.

Is My Facility a Good Candidate for CHP?

EPA Pesticide Factsheets

Learn if a facility is a good candidate for CHP by answering a list of questions, and access the CHP Spark Spread Estimator, a tool that helps evaluate a prospective CHP system for its potential economic feasibility.

CHPA, a Cysteine- and Histidine-Rich-Domain-Containing Protein, Contributes to Maintenance of the Diploid State in Aspergillus nidulans

PubMed Central

Sadanandom, Ari; Findlay, Kim; Doonan, John H.; Schulze-Lefert, Paul; Shirasu, Ken

2004-01-01

The alternation of eukaryotic life cycles between haploid and diploid phases is crucial for maintaining genetic diversity. In some organisms, the growth and development of haploid and diploid phases are nearly identical, and one might suppose that all genes required for one phase are likely to be critical for the other phase. Here, we show that targeted disruption of the chpA (cysteine- and histidine-rich-domain- [CHORD]-containing protein A) gene in haploid Aspergillus nidulans strains gives rise to chpA knockout haploids and heterozygous diploids but no chpA knockout diploids. A. nidulans chpA heterozygous diploids showed impaired conidiophore development and reduced conidiation. Deletion of chpA from diploid A. nidulans resulted in genome instability and reversion to a haploid state. Thus, our data suggest a vital role for chpA in maintenance of the diploid phase in A. nidulans. Furthermore, the human chpA homolog, Chp-1, was able to complement haploinsufficiency in A. nidulans chpA heterozygotes, suggesting that the function of CHORD-containing proteins is highly conserved in eukaryotes. PMID:15302831

Status of tubular SOFC field unit demonstrations

NASA Astrophysics Data System (ADS)

George, Raymond A.

Siemens Westinghouse is in the final stage of its tubular solid oxide fuel cell (SOFC) development program, and the program emphasis has shifted from basic technology development to cost reduction, scale-up and demonstration of pre-commercial power systems at customer sites. This paper describes our field unit demonstration program including the EDB/ELSAM 100-kW e combined heat and power (CHP) system, the Southern California Edison (SCE) 220-kW e pressurized SOFC/gas turbine (PSOFC/GT) power system, and the planned demonstrations of commercial prototype power systems. In the Spring of 1999, the EDB/ELSAM 100-kW e SOFC-CHP system produced 109 kW e net AC to the utility grid at 46% electrical efficiency and 65 kW t to the hot water district heating system, verifying the analytical predictions. The SCE 220-kW e PSOFC/GT power system will undergo factory startup in the Fall of 1999.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bourgeois, Tom

From October 1, 2009 through September 30, 2013 (“contract period”), the Northeast Clean Energy Application Center (“NE-CEAC”) worked in New York and New England (Connecticut, Rhode Island, Vermont, Massachusetts, New Hampshire, and Maine) to create a more robust market for the deployment of clean energy technologies (CETs) including combined heat and power (CHP), district energy systems (DES), and waste heat recovery (WHR) systems through the provision of technical assistance, education and outreach, and strategic market analysis and support for decision-makers. CHP, DES, and WHR can help reduce greenhouse gas emissions, reduce electrical and thermal energy costs, and provide more reliablemore » energy for users throughout the United States. The NE-CEAC’s efforts in the provision of technical assistance, education and outreach, and strategic market analysis and support for decision-makers helped advance the market for CETs in the Northeast thereby helping the region move towards the following outcomes: Reduction of greenhouse gas emissions and criteria pollutants; Improvements in energy efficiency resulting in lower costs of doing business; Productivity gains in industry and efficiency gains in buildings; Lower regional energy costs; Strengthened energy security; Enhanced consumer choice; Reduced price risks for end-users; and Economic development effects keeping more jobs and more income in our regional economy Over the contract period, NE-CEAC provided technical assistance to approximately 56 different potential end-users that were interested in CHP and other CETs for their facility or facilities. Of these 56 potential end-users, five new CHP projects totaling over 60 MW of install capacity became operational during the contract period. The NE-CEAC helped host numerous target market workshops, trainings, and webinars; and NE-CEAC staff delivered presentations at many other workshops and conferences. In total, over 60 different workshops, conferences, webinars, and presentation were hosted or delivered during the contract period. The NE-CEAC also produced publically available educational materials such as CHP project profiles. Finally, the NE-CEAC worked closely with the relevant state agencies involved with CHP development. In New York, the NE-CEAC played an important role in securing and maintaining funding for CHP incentive programs administered by the New York State Energy Research Development Authority. NE-CEAC was also involved in the NYC Mayor's Office DG Collaborative. The NECEAC was also named a strategic resource for the Connecticut Department of Energy and Environmental Protection’s innovative Microgrid Pilot Program.« less

ChpK and MazF of the toxin-antitoxin modules are involved in the virulence of Leptospira interrogans during infection.

PubMed

Komi, Komi Koukoura; Ge, Yu-Mei; Xin, Xiao-Yang; Ojcius, David M; Sun, Dexter; Hu, Wei-Lin; Zhao, Xin; Lin, Xu'ai; Yan, Jie

2015-01-01

Pathogenic Leptospira species are the causative agents of leptospirosis, a global zoonotic infectious disease. Toxin-antitoxin (TA) modules have been confirmed as stress-response elements that induce prokaryotic and eukaryotic cell-growth arrest or death, but their role in the virulence of Leptospira has not been reported. Here, we confirmed that all the tested leptospiral strains had the chpIK and mazEF TA modules with highly-conserved sequences. The transcription and expression of the chpI, chpK, mazE, and mazF genes of Leptospira interrogans strain Lai were significantly increased during infection of phorbol 12-myristate 13-acetate-induced human THP-1 macrophages. The toxic ChpK and MazF but not the antitoxic ChpI and MazE proteins were detectable in the cytoplasmic fraction of leptospire-infected THP-1 cells, indicating the external secretion of ChpK and MazF during infection. Transfection of the chpK or mazF gene caused decreased viability and necrosis in THP-1 cells, whereas the chpI or mazE gene transfection did not affect the viability of THP-1 cells but blocked the ChpK or MazF-induced toxicity. Deletion of the chpK or mazF gene also decreased the late-apoptotic and/or necrotic ratios of THP-1 cells at the late stages of infection. The recombinant protein MazF (rMazF) cleaved the RNAs but not the DNAs from Leptospira and THP-1 cells, and this RNA cleavage was blocked by rMazE. However, the rChpK had no RNA or DNA-degrading activity. All these findings indicate that the ChpK and MazF proteins in TA modules are involved in the virulence of L. interrogans during infection. Copyright © 2014 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.

CHP -- A revolution in the making

DOE Office of Scientific and Technical Information (OSTI.GOV)

Green, D.

1999-07-01

Liberalization, globalization, and particularly climate change are changing energy thinking. In the future, climate change will be tackled by improved energy efficiency and carbon neutral sources of energy, but much more could be done today by the more widespread use of CHP. CHP has made reasonably good progress in the UK and Europe, due to energy industry liberalization and the widespread availability of gas. But the pursuit of sustainability objectives requires government intervention into liberalized markets. While the current UK Government is a strong supporter of CHP, major opportunities to develop CHP were missed in favor of less efficient CCGTmore » power stations over the last decade. The two critical policy issues in the UK now are the proposed tax on the business use of energy and the current reform of electricity trading arrangements. Both could impact favorably on the development of CHP. The UK CHP Association, COGEN Europe and the International Cogeneration Alliance continue to press the case for CHP.« less

Off-loading of cyclic hydrostatic pressure promotes production of extracellular matrix by chondrocytes.

PubMed

Tatsumura, Masaki; Sakane, Masataka; Ochiai, Naoyuki; Mizuno, Shuichi

2013-01-01

The addition of cyclic hydrostatic pressure (cHP) to cell culture medium has been used to promote extracellular matrix (ECM) production by articular chondrocytes. Though a combination of cHP followed by atmospheric pressure (AP) has been examined previously, the rationale of such a combination was unclear. We compared the effects of loading once versus twice (combinations of cHP followed by AP) regarding both gene expression and biochemical and histological phenotypes of chondrocytes. Isolated bovine articular chondrocytes were embedded in a collagen gel and incubated for 14 days under conditions combining cHP and AP. The gene expression of aggrecan core protein and collagen type II were upregulated in response to cHP, and those levels were maintained for at least 4 days after cHP treatment. Accumulation of cartilage-specific sulfated glycosaminoglycans following cHP for 7 days and subsequent AP for 7 days was significantly greater than that of the AP control (p < 0.05). Therefore, incubation at AP after loading with cHP was found to beneficially affect ECM accumulation. Manipulating algorithms of cHP combined with AP will be useful in producing autologous chondrocyte-based cell constructs for implantation. © 2014 S. Karger AG, Basel.

Modelling a demand driven biogas system for production of electricity at peak demand and for production of biomethane at other times.

PubMed

O'Shea, R; Wall, D; Murphy, J D

2016-09-01

Four feedstocks were assessed for use in a demand driven biogas system. Biomethane potential (BMP) assays were conducted for grass silage, food waste, Laminaria digitata and dairy cow slurry. Semi-continuous trials were undertaken for all feedstocks, assessing biogas and biomethane production. Three kinetic models of the semi-continuous trials were compared. A first order model most accurately correlated with gas production in the pulse fed semi-continuous system. This model was developed for production of electricity on demand, and biomethane upgrading. The model examined a theoretical grass silage digester that would produce 435kWe in a continuous fed system. Adaptation to demand driven biogas required 187min to produce sufficient methane to run a 2MWe combined heat and power (CHP) unit for 60min. The upgrading system was dispatched 71min following CHP shutdown. Of the biogas produced 21% was used in the CHP and 79% was used in the upgrading system. Copyright © 2016 Elsevier Ltd. All rights reserved.

4E analysis and multi objective optimization of a micro gas turbine and solid oxide fuel cell hybrid combined heat and power system

NASA Astrophysics Data System (ADS)

Sanaye, Sepehr; Katebi, Arash

2014-02-01

Energy, exergy, economic and environmental (4E) analysis and optimization of a hybrid solid oxide fuel cell and micro gas turbine (SOFC-MGT) system for use as combined generation of heat and power (CHP) is investigated in this paper. The hybrid system is modeled and performance related results are validated using available data in literature. Then a multi-objective optimization approach based on genetic algorithm is incorporated. Eight system design parameters are selected for the optimization procedure. System exergy efficiency and total cost rate (including capital or investment cost, operational cost and penalty cost of environmental emissions) are the two objectives. The effects of fuel unit cost, capital investment and system power output on optimum design parameters are also investigated. It is observed that the most sensitive and important design parameter in the hybrid system is fuel cell current density which has a significant effect on the balance between system cost and efficiency. The selected design point from the Pareto distribution of optimization results indicates a total system exergy efficiency of 60.7%, with estimated electrical energy cost 0.057 kW-1 h-1, and payback period of about 6.3 years for the investment.

Computer experimental analysis of the CHP performance of a 100 kW e SOFC Field Unit by a factorial design

NASA Astrophysics Data System (ADS)

Calì, M.; Santarelli, M. G. L.; Leone, P.

Gas Turbine Technologies (GTT) and Politecnico di Torino, both located in Torino (Italy), have been involved in the design and installation of a SOFC laboratory in order to analyse the operation, in cogenerative configuration, of the CHP 100 kW e SOFC Field Unit, built by Siemens-Westinghouse Power Corporation (SWPC), which is at present (May 2005) starting its operation and which will supply electric and thermal power to the GTT factory. In order to take the better advantage from the analysis of the on-site operation, and especially to correctly design the scheduled experimental tests on the system, we developed a mathematical model and run a simulated experimental campaign, applying a rigorous statistical approach to the analysis of the results. The aim of this work is the computer experimental analysis, through a statistical methodology (2 k factorial experiments), of the CHP 100 performance. First, the mathematical model has been calibrated with the results acquired during the first CHP100 demonstration at EDB/ELSAM in Westerwoort. After, the simulated tests have been performed in the form of computer experimental session, and the measurement uncertainties have been simulated with perturbation imposed to the model independent variables. The statistical methodology used for the computer experimental analysis is the factorial design (Yates' Technique): using the ANOVA technique the effect of the main independent variables (air utilization factor U ox, fuel utilization factor U F, internal fuel and air preheating and anodic recycling flow rate) has been investigated in a rigorous manner. Analysis accounts for the effects of parameters on stack electric power, thermal recovered power, single cell voltage, cell operative temperature, consumed fuel flow and steam to carbon ratio. Each main effect and interaction effect of parameters is shown with particular attention on generated electric power and stack heat recovered.

Detailed thermodynamic investigation of an ICE-driven, natural gas-fueled, 1 kWe micro-CHP generator

DOE Office of Scientific and Technical Information (OSTI.GOV)

Taie, Zachary; West, Brian H.; Szybist, James P.

Here, the purpose of this work is to record the baseline performance of a state-of-the-art micro-combined heat and power (mCHP) system. A second goal of this work is to provide detailed thermodynamic first and second law performance measurements of the internal combustion engine and generator subsystems. A global technology survey was conducted to identify the leading mCHP systems in the 1 kW electric range. The Honda ECOWILL was identified as the state-of-the-art system in the United States, and an unused unit was procured. The ECOWILL underwent round-robin performance testing at three independent laboratories. First law (energy) and second law (exergy)more » analyses were conducted on the steady state data. Analysis revealed the ECOWILL operated at a first law electrical efficiency of 23.5 ± 0.4% and a utilization factor of 74.5 ± 3.2%. The primary energy loss was heat transfer from the device, followed by chemical and thermal energy in the exhaust stack. The second law analysis showed the ECOWILL operated at a second law electrical efficiency of 23.1 ± 0.4% and total (including exergy in both the electrical and recovered waste heat streams) second law efficiency of 30.2 ± 2.3%. Key areas of exergy destruction were, in decreasing magnitude, heat transfer, combustion irreversibility, and generator and friction losses.« less

Detailed thermodynamic investigation of an ICE-driven, natural gas-fueled, 1 kWe micro-CHP generator

DOE PAGES

Taie, Zachary; West, Brian H.; Szybist, James P.; ...

2018-05-03

Here, the purpose of this work is to record the baseline performance of a state-of-the-art micro-combined heat and power (mCHP) system. A second goal of this work is to provide detailed thermodynamic first and second law performance measurements of the internal combustion engine and generator subsystems. A global technology survey was conducted to identify the leading mCHP systems in the 1 kW electric range. The Honda ECOWILL was identified as the state-of-the-art system in the United States, and an unused unit was procured. The ECOWILL underwent round-robin performance testing at three independent laboratories. First law (energy) and second law (exergy)more » analyses were conducted on the steady state data. Analysis revealed the ECOWILL operated at a first law electrical efficiency of 23.5 ± 0.4% and a utilization factor of 74.5 ± 3.2%. The primary energy loss was heat transfer from the device, followed by chemical and thermal energy in the exhaust stack. The second law analysis showed the ECOWILL operated at a second law electrical efficiency of 23.1 ± 0.4% and total (including exergy in both the electrical and recovered waste heat streams) second law efficiency of 30.2 ± 2.3%. Key areas of exergy destruction were, in decreasing magnitude, heat transfer, combustion irreversibility, and generator and friction losses.« less

Using Cost-Effectiveness Tests to Design CHP Incentive Programs

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tidball, Rick

This paper examines the structure of cost-effectiveness tests to illustrate how they can accurately reflect the costs and benefits of CHP systems. This paper begins with a general background discussion on cost-effectiveness analysis of DER and then describes how cost-effectiveness tests can be applied to CHP. Cost-effectiveness results are then calculated and analyzed for CHP projects in five states: Arkansas, Colorado, Iowa, Maryland, and North Carolina. Based on the results obtained for these five states, this paper offers four considerations to inform regulators in the application of cost-effectiveness tests in developing CHP programs.

Comparative analysis of gas and coal-fired power generation in ultra-low emission condition using life cycle assessment (LCA)

NASA Astrophysics Data System (ADS)

Yin, Libao; Liao, Yanfen; Liu, Guicai; Liu, Zhichao; Yu, Zhaosheng; Guo, Shaode; Ma, Xiaoqian

2017-05-01

Energy consumption and pollutant emission of natural gas combined cycle power-generation (NGCC), liquefied natural gas combined cycle power-generation (LNGCC), natural gas combined heat and power generation (CHP) and ultra-supercritical power generation with ultra-low gas emission (USC) were analyzed using life cycle assessment method, pointing out the development opportunity and superiority of gas power generation in the period of coal-fired unit ultra-low emission transformation. The results show that CO2 emission followed the order: USC>LNGCC>NGCC>CHP the resource depletion coefficient of coal-fired power generation was lower than that of gas power generation, and the coal-fired power generation should be the main part of power generation in China; based on sensitivity analysis, improving the generating efficiency or shortening the transportation distance could effectively improve energy saving and emission reduction, especially for the coal-fired units, and improving the generating efficiency had a great significance for achieving the ultra-low gas emission.

Calcineurin B homologous protein 3 negatively regulates cardiomyocyte hypertrophy via inhibition of glycogen synthase kinase 3 phosphorylation.

PubMed

Kobayashi, Soushi; Nakamura, Tomoe Y; Wakabayashi, Shigeo

2015-07-01

Cardiac hypertrophy is a leading cause of serious heart diseases. Although many signaling molecules are involved in hypertrophy, the functions of some proteins in this process are still unknown. Calcineurin B homologous protein 3 (CHP3)/tescalcin is an EF-hand Ca(2+)-binding protein that is abundantly expressed in the heart; however, the function of CHP3 is unclear. Here, we aimed to identify the cardiac functions of CHP3. CHP3 was expressed in hearts at a wide range of developmental stages and was specifically detected in neonatal rat ventricular myocytes (NRVMs) but not in cardiac fibroblasts in culture. Moreover, knockdown of CHP3 expression using adenoviral-based RNA interference in NRVMs resulted in enlargement of cardiomyocyte size, concomitant with increased expression of a pathological hypertrophy marker ANP. This same treatment elevated glycogen synthase kinase (GSK3α/β) phosphorylation, which is known to inhibit GSK3 function. In contrast, CHP3 overexpression blocked the insulin-induced phosphorylation of GSK3α/β without affecting the phosphorylation of Akt, which is an upstream kinase of GSK3α/β, in HEK293 cells, and it inhibited both IGF-1-induced phosphorylation of GSK3β and cardiomyocyte hypertrophy in NRVMs. Co-immunoprecipitation experiments revealed that GSK3β interacted with CHP3. However, a Ca(2+)-binding-defective mutation of CHP3 (CHP3-D123A) also interacted with GSK3β and had the same inhibitory effect on GSK3α/β phosphorylation, suggesting that the action of CHP3 was independent of Ca(2+). These findings suggest that CHP3 functions as a novel negative regulator of cardiomyocyte hypertrophy via inhibition of GSK3α/β phosphorylation and subsequent enzymatic activation of GSK3α/β. Copyright © 2015 Elsevier Ltd. All rights reserved.

pH-Induced interfacial properties of Chaplin E from Streptomyces coelicolor.

PubMed

Dokouhaki, Mina; Hung, Andrew; Prime, Emma L; Qiao, Greg G; Day, Li; Gras, Sally L

2017-12-01

Chaplin E, or Chp E, is a surface active peptide secreted by Streptomyces coelicolor that adopts different structures depending on solution pH but the effect of these structures on the interfacial properties of Chp E is not known. In experiments paired with simulations, Chp E was found to display pH-dependent interfacial assembly and surface activity. At pH 3.0, Chp E formed an ordered non-amyloidal interfacial film with high surface activity; while at pH 10.0, Chp E self-assembled into a heterogeneous film containing randomly arranged fibrils at the interface that was less surface active compared to the film formed at pH 3.0. In simulations at pH 10.0, Chp E molecules showed a higher propensity for dimerization within the solution phase, lower rate of adsorption to the interface and tighter inter-molecular associations at the interface, consistent with the lower surface activity and smaller interfacial area coverage per molecule measured at this pH compared to at pH 3.0. A model is presented for the role of Chp E in the developmental differentiation of Streptomyces coelicolor, where Chp E contributes to changes in surface tension at low pH and the formation of fibrils on the surface of aerial hyphae at high pH. Our data also suggest Chp E could be a promising surface active agent with functional activity that can be controlled by pH. Copyright © 2017 Elsevier B.V. All rights reserved.

The Effects of Cyclic Hydrostatic Pressure on Chondrogenesis and Viability of Human Adipose- and Bone Marrow-Derived Mesenchymal Stem Cells in Three-Dimensional Agarose Constructs

PubMed Central

Puetzer, Jennifer; Williams, John; Gillies, Allison; Bernacki, Susan

2013-01-01

This study investigates the effects of cyclic hydrostatic pressure (CHP) on chondrogenic differentiation of human adipose-derived stem cells (hASCs) in three-dimensional (3-D) agarose constructs maintained in a complete growth medium without soluble chondrogenic inducing factors. hASCs were seeded in 2% agarose hydrogels and exposed to 7.5 MPa CHP for 4 h per day at a frequency of 1 Hz for up to 21 days. On days 0, 7, 14, and 21, the expression levels of collagen II, Sox9, aggrecan, and cartilage oligomeric matrix protein (COMP) were examined by real-time reverse transcriptase–polymerase chain reaction analysis. Gene expression analysis found collagen II mRNA expression in only the CHP-loaded construct at day 14 and at no other time during the study. CHP-loaded hASCs exhibited upregulated mRNA expression of Sox9, aggrecan, and COMP at day 7 relative to unloaded controls, suggesting that CHP initiated chondrogenic differentiation of hASCs in a manner similar to human bone marrow-derived mesenchymal stem cells (hMSC). By day 14, however, loaded hASC constructs exhibited significantly lower mRNA expression of the chondrogenic markers than unloaded controls. Additionally, by day 21, the samples exhibited little measurable mRNA expression at all, suggesting a decreased viability. Histological analysis validated the lack of mRNA expression at day 21 for both the loaded and unloaded control samples with a visible decrease in the cell number and change in morphology. A comparative study with hASCs and hMSCs further examined long-term cell viability in 3-D agarose constructs of both cell types. Decreased cell metabolic activity was observed throughout the 21-day experimental period in both the CHP-loaded and control constructs of both hMSCs and hASCs, suggesting a decrease in cell metabolic activity, alluding to a decrease in cell viability. This suggests that a 2% agarose hydrogel may not optimally support hASC or hMSC viability in a complete growth medium in the absence of soluble chondrogenic inducing factors over long culture durations. This is the first study to examine the ability of mechanical stimuli alone, in the absence of chondrogenic factors transforming growth factor beta (TGF-β)3, TGF-β1 and/or bone morphogenetic protein 6 (BMP6) to induce hASC chondrogenic differentiation. The findings of this study suggest that CHP initiates hASC chondrogenic differentiation, even in the absence of soluble chondrogenic inductive factors, confirming the importance of considering both mechanical stimuli and appropriate 3-D culture for cartilage tissue engineering using hASCs. PMID:22871265

Immunohistochemical characterization of hemangiopericytomas and other spindle cell tumors in the dog.

PubMed

Pérez, J; Bautista, M J; Rollón, E; de Lara, F C; Carrasco, L; Martin de las Mulas, J

1996-07-01

The immunohistochemical expression of muscle actin has been studied in 45 canine hemangiopericytomas (CHP) using a monoclonal antibody (HHF35) and formalin-fixed, paraffin-embedded specimens. The distribution of vimentin, desmin, cytokeratins, lysozyme, factor VIII-related antigen, S-100 protein, and glial fibrillary acidic protein was studied both in CHP and in some canine soft-tissue neoplasms (seven fibrosarcomas, seven benign schwannomas, seven benign fibrous histiocytomas, and six leiomyosarcomas) used as controls for differential diagnosis. All CHP and control tumors expressed vimentin. Twenty-three CHP expressed muscle actin, whereas all control tumors analyzed were muscle actin-negative, with the exception of leiomyosarcomas. Among muscle actin- and vimentin-positive CHP, one case could be reclassified as leiomyosarcoma because it was desmin-positive, two cases expressed lysozyme, and nine cases expressed S-100 protein. Among muscle actin-negative and vimentin-positive CHP, seven expressed S-100 protein. In addition, S-100 protein was detected in five schwannomas. All CHP and control tumors analyzed were negative for cytokeratins, factor VIII-related antigen, and glial fibrillary acidic protein. Our results support the hypothesis of a pericytic origin of CHP, and suggest that muscle actin, desmin, vimentin, and lysozyme could be useful for the differential diagnosis of canine spindle cell tumors, but not all these neoplasms can be identified with these tumor tissue markers.

CHP as a Boiler Replacement Opportunity (Webinar) – April 30, 2013

EPA Pesticide Factsheets

This webinar provides information about the benefits of replacing a boiler with a CHP system, describes CHP project analysis and delivery processes, and highlights a case study at Penn State University.

Glossary – dCHPP (CHP Policies and incentives database)

EPA Pesticide Factsheets

This glossary provides descriptions of the policy and incentive types included in the CHP Partnership's CHP Policies and incentives database (dCHPP), as well as the frequency with which the EPA updates each type.

Scoring LEED® Points with CHP (Webinar) – July 21, 2015

EPA Pesticide Factsheets

This webinar provides information about how to earn points with CHP in the LEED green building rating system, describes modern absorption chillers and their role with CHP and LEED, and presents case studies.

Combined Heat and Power (CHP) Partnership

EPA Pesticide Factsheets

The CHP Partnership seeks to reduce air pollution and water usage associated with electric power generation by promoting the use of CHP. The Partnership works to remove policy barriers and to facilitate the development of new projects.

CHP Energy and Emissions Savings Calculator

EPA Pesticide Factsheets

Download the CHP Emissions Calculator, a tool that calculates the difference between the anticipated carbon dioxide, methane, nitrous oxide, sulfur dioxide, and nitrogen oxide emissions from a CHP system to those of a separate heat and power system.

CHP1002, a novel andrographolide derivative, inhibits pro-inflammatory inducible nitric oxide synthase and cyclooxygenase-2 expressions in RAW264.7 macrophages via up-regulation of heme oxygenase-1 expression.

PubMed

Zhang, Bo; Yan, Lingdi; Zhou, Peilan; Dong, Zhaoqi; Feng, Siliang; Liu, Keliang; Gong, Zehui

2013-02-01

Andrographolides, a type of diterpene lactone, are widely known to have anti-inflammatory and anti-oxidative properties. CHP1002, a synthetic derivative of andrographolide, has similar anti-inflammatory action in mouse ear swelling test and rat paw edema test. In the present study, the mechanism of anti-inflammatory effects of CHP1002 was investigated in RAW264.7 macrophages. CHP1002 potently suppressed inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expressions in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages. CHP1002 reduced the production of iNOS-derived nitric oxide (NO) and COX-2-derived prostaglandin E2 (PGE2). CHP1002 induced heme oxygenase-1 (HO-1) expression via activation of extracellular signal-regulated kinase (ERK) and NF-E2 related factor 2 transcription factor (Nrf2). Down-regulation of LPS-induced iNOS and COX-2 expressions was partially reversed by the HO-1 inhibitor zinc protoporphyrin (ZnPP). In addition, CHP1002 significantly attenuated LPS-induced TNF-α, IL-1β and IL-6 production. CHP1002 effectively induced HO-1 and was capable of inhibiting some macrophage-derived pro-inflammatory mediators, which may be closely correlated with its anti-inflammatory action. Copyright © 2012 Elsevier B.V. All rights reserved.

Nanogel antigenic protein-delivery system for adjuvant-free intranasal vaccines

NASA Astrophysics Data System (ADS)

Nochi, Tomonori; Yuki, Yoshikazu; Takahashi, Haruko; Sawada, Shin-Ichi; Mejima, Mio; Kohda, Tomoko; Harada, Norihiro; Kong, Il Gyu; Sato, Ayuko; Kataoka, Nobuhiro; Tokuhara, Daisuke; Kurokawa, Shiho; Takahashi, Yuko; Tsukada, Hideo; Kozaki, Shunji; Akiyoshi, Kazunari; Kiyono, Hiroshi

2010-07-01

Nanotechnology is an innovative method of freely controlling nanometre-sized materials. Recent outbreaks of mucosal infectious diseases have increased the demands for development of mucosal vaccines because they induce both systemic and mucosal antigen-specific immune responses. Here we developed an intranasal vaccine-delivery system with a nanometre-sized hydrogel (`nanogel') consisting of a cationic type of cholesteryl-group-bearing pullulan (cCHP). A non-toxic subunit fragment of Clostridium botulinum type-A neurotoxin BoHc/A administered intranasally with cCHP nanogel (cCHP-BoHc/A) continuously adhered to the nasal epithelium and was effectively taken up by mucosal dendritic cells after its release from the cCHP nanogel. Vigorous botulinum-neurotoxin-A-neutralizing serum IgG and secretory IgA antibody responses were induced without co-administration of mucosal adjuvant. Importantly, intranasally administered cCHP-BoHc/A did not accumulate in the olfactory bulbs or brain. Moreover, intranasally immunized tetanus toxoid with cCHP nanogel induced strong tetanus-toxoid-specific systemic and mucosal immune responses. These results indicate that cCHP nanogel can be used as a universal protein-based antigen-delivery vehicle for adjuvant-free intranasal vaccination.

EPA's Air Quality Rules for Reciprocating Internal Combustion Engines (RICE) and their Application to CHP (Webinar) – June 24, 2014

EPA Pesticide Factsheets

This webinar discusses the effect of EPA's air quality regulations on CHP facilities and stationary RICE, and describes how CHP systems can comply with air quality regulations by using stationary RICE.

Biallelic CHP1 mutation causes human autosomal recessive ataxia by impairing NHE1 function

PubMed Central

Mendoza-Ferreira, Natalia; Coutelier, Marie; Janzen, Eva; Hosseinibarkooie, Seyyedmohsen; Löhr, Heiko; Schneider, Svenja; Milbradt, Janine; Karakaya, Mert; Riessland, Markus; Pichlo, Christian; Torres-Benito, Laura; Singleton, Andrew; Zuchner, Stephan; Brice, Alexis; Durr, Alexandra; Hammerschmidt, Matthias; Stevanin, Giovanni

2018-01-01

Objective: To ascertain the genetic and functional basis of complex autosomal recessive cerebellar ataxia (ARCA) presented by 2 siblings of a consanguineous family characterized by motor neuropathy, cerebellar atrophy, spastic paraparesis, intellectual disability, and slow ocular saccades. Methods: Combined whole-genome linkage analysis, whole-exome sequencing, and focused screening for identification of potential causative genes were performed. Assessment of the functional consequences of the mutation on protein function via subcellular fractionation, size-exclusion chromatography, and fluorescence microscopy were done. A zebrafish model, using Morpholinos, was generated to study the pathogenic effect of the mutation in vivo. Results: We identified a biallelic 3-bp deletion (p.K19del) in CHP1 that cosegregates with the disease. Neither focused screening for CHP1 variants in 2 cohorts (ARCA: N = 319 and NeurOmics: N = 657) nor interrogating GeneMatcher yielded additional variants, thus revealing the scarcity of CHP1 mutations. We show that mutant CHP1 fails to integrate into functional protein complexes and is prone to aggregation, thereby leading to diminished levels of soluble CHP1 and reduced membrane targeting of NHE1, a major Na+/H+ exchanger implicated in syndromic ataxia-deafness. Chp1 deficiency in zebrafish, resembling the affected individuals, led to movement defects, cerebellar hypoplasia, and motor axon abnormalities, which were ameliorated by coinjection with wild-type, but not mutant, human CHP1 messenger RNA. Conclusions: Collectively, our results identified CHP1 as a novel ataxia-causative gene in humans, further expanding the spectrum of ARCA-associated loci, and corroborated the crucial role of NHE1 within the pathogenesis of these disorders. PMID:29379881

TaCHP: a wheat zinc finger protein gene down-regulated by abscisic acid and salinity stress plays a positive role in stress tolerance.

PubMed

Li, Cuiling; Lv, Jian; Zhao, Xin; Ai, Xinghui; Zhu, Xinlei; Wang, Mengcheng; Zhao, Shuangyi; Xia, Guangmin

2010-09-01

The plant response to abiotic stresses involves both abscisic acid (ABA)-dependent and ABA-independent signaling pathways. Here we describe TaCHP, a CHP-rich (for cysteine, histidine, and proline rich) zinc finger protein family gene extracted from bread wheat (Triticum aestivum), is differentially expressed during abiotic stress between the salinity-sensitive cultivar Jinan 177 and its tolerant somatic hybrid introgression cultivar Shanrong No.3. TaCHP expressed in the roots of seedlings at the three-leaf stage, and the transcript localized within the cells of the root tip cortex and meristem. TaCHP transcript abundance was higher in Shanrong No.3 than in Jinan 177, but was reduced by the imposition of salinity or drought stress, as well as by the exogenous supply of ABA. When JN17, a salinity hypersensitive wheat cultivar, was engineered to overexpress TaCHP, its performance in the face of salinity stress was improved, and the ectopic expression of TaCHP in Arabidopsis (Arabidopsis thaliana) also improved the ability of salt tolerance. The expression level of a number of stress reporter genes (AtCBF3, AtDREB2A, AtABI2, and AtABI1) was raised in the transgenic lines in the presence of salinity stress, while that of AtMYB15, AtABA2, and AtAAO3 was reduced in its absence. The presence in the upstream region of the TaCHP open reading frame of the cis-elements ABRE, MYBRS, and MYCRS suggests that it is a component of the ABA-dependent and -independent signaling pathways involved in the plant response to abiotic stress. We suggest that TaCHP enhances stress tolerance via the promotion of CBF3 and DREB2A expression.

Treatment of CHP in LEED® for Building Design and Construction: New Construction and Major Renovations

EPA Pesticide Factsheets

This factsheet introduces CHP and its benefits to architects and engineers, and summarizes how CHP is treated under the LEED® for Building Design and Construction: New Construction and Major Renovations (LEED BD+C: New Construction) rating system.

ChpA Controls Twitching Motility and Broadly Affects Gene Expression in the Biological Control Agent Lysobacter enzymogenes.

PubMed

Zhou, Mimi; Shen, Danyu; Xu, Gaoge; Liu, Fengquan; Qian, Guoliang

2017-05-01

Lysobacter enzymogenes (L. enzymogenes) is an agriculturally important Gram-negative bacterium that employs T4P (type IV pili)-driven twitching motility to exhibit its antifungal function. Yet, it is still unclear how this bacterium regulates its twitching motility. Here, by using strain OH11 as the working model organism, we showed that a hybrid two-component system ChpA acts as a positive regulator in controlling twitching motility in L. enzymogenes. ChpA is a hybrid TCS (two-component transduction system) contains 7 domains including those for auto-phosphorylation and phosphate group transfer, as well as a phosphate receiver (REC) domain. Mutation of chpA completely abolished the wild-type twitching motility, as evidenced by the absence of mobile cells at the margin of the mutant colonies. Further studies of domain-deletion and phenotypic characterization reveal that domains responsible for phosphorylation and phosphotransfer, but not the REC domain, were indispensable for ChpA in regulating twitching motility. Transcriptome analyses of the chpA knockout strain indicated that ChpA was extensively involved in controlling expression of a wide variety of genes (totaling 243). The products of these differentially expressed genes were involved in multiple physiological and biological functions in L. enzymogenes. Thus, we have not only identified a new regulator controlling twitching motility in L. enzymogenes, but also provided the first report demonstrating the broad impact of the conserved ChpA in gene regulation in Gram-negative bacteria.

A new market risk model for cogeneration project financing---combined heat and power development without a power purchase agreement

NASA Astrophysics Data System (ADS)

Lockwood, Timothy A.

Federal legislative changes in 2006 no longer entitle cogeneration project financings by law to receive the benefit of a power purchase agreement underwritten by an investment-grade investor-owned utility. Consequently, this research explored the need for a new market-risk model for future cogeneration and combined heat and power (CHP) project financing. CHP project investment represents a potentially enormous energy efficiency benefit through its application by reducing fossil fuel use up to 55% when compared to traditional energy generation, and concurrently eliminates constituent air emissions up to 50%, including global warming gases. As a supplemental approach to a comprehensive technical analysis, a quantitative multivariate modeling was also used to test the statistical validity and reliability of host facility energy demand and CHP supply ratios in predicting the economic performance of CHP project financing. The resulting analytical models, although not statistically reliable at this time, suggest a radically simplified CHP design method for future profitable CHP investments using four easily attainable energy ratios. This design method shows that financially successful CHP adoption occurs when the average system heat-to-power-ratio supply is less than or equal to the average host-convertible-energy-ratio, and when the average nominally-rated capacity is less than average host facility-load-factor demands. New CHP investments can play a role in solving the world-wide problem of accommodating growing energy demand while preserving our precious and irreplaceable air quality for future generations.

Credits for Combined Heat and Power (CHP) in Output-Based Environmental Regulations (OBR), USCHPA 2012 Spring Policy Forum (Presentation) – May 16, 2012

EPA Pesticide Factsheets

This presentation describes the importance of output-based regulations in recognizing the environmental and energy benefits of CHP, and how OBR can be designed appropriately to incorporate the characteristics of CHP systems.

Exploring CHP: What It Is and How It Is Used (Webinar) – May 20 and June 17, 2015

EPA Pesticide Factsheets

This is a two-part webinar. Part 1 provides information about the benefits of CHP systems and the state and federal policies and incentives that support their development. Part 2 describes the various CHP technologies and their applications.

Soil organic matter-hydrogen peroxide dynamics in the treatment of contaminated soils and groundwater using catalyzed H2O2 propagations (modified Fenton's reagent).

PubMed

Bissey, Lauren L; Smith, Jeffrey L; Watts, Richard J

2006-07-01

The interactions between catalyzed H(2)O(2) propagations (CHP-i.e. modified Fenton's reagent) and soil organic matter (SOM) during the treatment of contaminated soils and groundwater was studied in a well-characterized surface soil. The fate of two fractions of SOM, particulate organic matter (POM) and nonparticulate organic matter (NPOM), during CHP reactions was evaluated using concentrations of hydrogen peroxide from 0.5 to 3M catalyzed by soluble iron (III), an iron (III)-ethylenediamine tetraacetic acid (EDTA) chelate, or naturally-occurring soil minerals. The destruction of total SOM in CHP systems was directly proportional to the hydrogen peroxide dosage, and was significantly greater at pH 3 than at neutral pH; furthermore, SOM destruction occurred predominantly in the NPOM fraction. At pH 3, SOM did not affect hydrogen peroxide decomposition rates or hydroxyl radical activity in CHP reactions. However, at neutral pH, increasing the mass of SOM decreased the hydrogen peroxide decomposition rate and increased the rate of hydroxyl radical generation in CHP systems. These results show that, while CHP reactions destroy some of the organic carbon pools, SOM does not have a significant effect on the CHP treatment of soils and groundwater.

In vitro fermentation characteristics of novel fibers, coconut endosperm fiber and chicory pulp, using canine fecal inoculum.

PubMed

de Godoy, M R C; Mitsuhashi, Y; Bauer, L L; Fahey, G C; Buff, P R; Swanson, K S

2015-01-01

The objective of this experiment was to determine the effects of in vitro fermentation of coconut endosperm fiber (CEF), chicory pulp (CHP), and selective blends of these substrates on SCFA production and changes in microbiota using canine fecal inocula. A total of 6 individual substrates, including short-chain fructooligosaccharide (scFOS; a well-established prebiotic source), pectin (PEC; used as a positive control), pelletized cellulose (PC; used as a negative control), beet pulp (BP; considered the gold standard fiber source in pet foods), CEF, and CHP, and 3 CEF:CHP blends (75:25% CEF:CHP [B1], 50:50% CEF:CHP [B2], and 25:75% CEF:CHP [B3]) were tested. Triplicate samples of each substrate were fermented for 0, 8, and 16 h after inoculation. A significant substrate × time interaction (P < 0.05) was observed for pH change and acetate, propionate, butyrate, and total SCFA concentrations. After 8 and 16 h, pH change was greatest for scFOS (-2.0 and -3.0, respectively) and smallest for PC (0.0 and -0.1, respectively). After 16 h, CEF had a greater butyrate concentration than CHP and all the CEF:CHP blends and it was not different than PEC. The substrate × time interaction was significant for bifidobacteria (P < 0.05) and lactobacilli (P < 0.05). After 8 h, bifidobacteria was greatest for BP and lowest for PC (12.7 and 10.0 log10 cfu/tube, respectively). After 16 h, PC had the lowest and scFOS had the greatest bifidobacteria (6.7 and 13.3 log10 cfu/tube, respectively). In general, CEF, CHP, and their blends had similar bifidobacteria populations after 8 and 16 h of fermentation when compared with BP and scFOS. After 16 h, lactobacilli populations were greatest for B1, B2, B3, BP, and scFOS, intermediate for PEC, and lowest for PC (P < 0.05). Overall, our data suggest that CEF had a butyrogenic effect and that CEF, CHP, and their blends had similar bifidobacteria and lactobacilli populations as popular prebiotic and fiber substrates. Future research should investigate the effects of CEF, CHP, and their blends on gastrointestinal health and fecal quality in dogs.

U.S. Department of Energy Pacific Region Clean Energy Application Center (PCEAC)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lipman, Tim; Kammen, Dan; McDonell, Vince

2013-09-30

The U.S. Department of Energy Pacific Region Clean Energy Application Center (PCEAC) was formed in 2009 by the U.S. Department of Energy (DOE) and the California Energy Commission to provide education, outreach, and technical support to promote clean energy -- combined heat and power (CHP), district energy, and waste energy recovery (WHP) -- development in the Pacific Region. The region includes California, Nevada, Hawaii, and the Pacific territories. The PCEAC was operated as one of nine regional clean energy application centers, originally established in 2003/2004 as Regional Application Centers for combined heat and power (CHP). Under the Energy Independence andmore » Security Act of 2007, these centers received an expanded charter to also promote district energy and waste energy recovery, where economically and environmentally advantageous. The centers are working in a coordinated fashion to provide objective information on clean energy system technical and economic performance, direct technical assistance for clean energy projects and additional outreach activities to end users, policy, utility, and industry stakeholders. A key goal of the CEACs is to assist the U.S. in achieving the DOE goal to ramp up the implementation of CHP to account for 20% of U.S. generating capacity by 2030, which is estimated at a requirement for an additional 241 GW of installed clean technologies. Additional goals include meeting the Obama Administration goal of 40 GW of new CHP by 2020, key statewide goals such as renewable portfolio standards (RPS) in each state, California’s greenhouse gas emission reduction goals under AB32, and Governor Brown’s “Clean Energy Jobs Plan” goal of 6.5 GW of additional CHP over the next twenty years. The primary partners in the PCEAC are the Department of Civil and Environmental Engineering and the Energy and Resources Group (ERG) at UC Berkeley, the Advanced Power and Energy Program (APEP) at UC Irvine, and the Industrial Assessment Centers (IAC) at San Diego State University and San Francisco State University. The center also worked with a wide range of affiliated groups and industry, government, NGO, and academic stakeholders to conduct a series of CHP education and outreach, project technical support, and related activities for the Pacific region. Key PCEAC tasks have included: - Preparing, organizing and conducting educational seminars on various aspects of CHP - Conducting state baseline assessments for CHP - Working with state energy offices to prepare state CHP action plans - Providing technical support services including CHP/district energy project feasibility screenings - Working with state agencies on CHP policy development - Developing additional CHP educational materials The primary specific services that PCEAC has offered include: - A CHP “information clearinghouse “ website: http://www.pacificcleanenergy.org - Site evaluations and potential projects screenings - Assessment of CHP status, potential, and key issues for each state - Information and training workshops - Policy and regulatory guidance documents and other interactions These services were generally offered at no cost to client groups based on the DOE funding and additional activities supported by the California Energy Commission, except for the in-kind staff resources needed to provide input data and support to PCEAC assessments at host sites. Through these efforts, the PCEAC reached thousands of end-users and directly worked with several dozen organizations and potential CHP “host sites” from 2009-2013. The major activities and outcomes of PCEAC project work are described.« less

Self-assembled nanogels of cholesteryl-modified polysaccharides: effect of the polysaccharide structure on their association characteristics in the dilute and semidilute regimes.

PubMed

Akiyama, Eri; Morimoto, Nobuyuki; Kujawa, Piotr; Ozawa, Yayoi; Winnik, Françoise M; Akiyoshi, Kazunari

2007-08-01

The assembly of cholesteryl derivatives of the highly branched polysaccharide mannan Mw = (5.2 x 104 g/mol) in dilute aqueous solution was investigated by 1H nuclear magnetic resonance (NMR) spectroscopy, size-exclusion chromatography coupled with multiangle laser scattering (SEC-MALLS), dynamic light scattering (DLS), atomic force microscopy (AFM), fluorescence quenching, and fluorescence depolarization measurements. In the dilute regime, cholesteryl-bearing mannans (CHM) containing approximately 1 cholesteryl group per 100 mannopyranose units formed nanogels with a hydrodynamic radius (RH) of approximately 20 nm containing approximately 8 macromolecules held together via hydrophobic nanodomains consisting of approximately 9 cholesteryl groups. Their density Phih ( approximately 0.02) was significantly lower than the density ( approximately 0.16) of nanogels formed by a cholesteryl derivative of the linear polysaccharide pullulan (CHP) of identical molar mass and level of cholesteryl substitution. In the semidilute regime, CHM nanogels formed a macrogel network for concentrations higher than 12.5% w/w, whereas CHP nanogels underwent macrogelation only above a threshold concentration of 8.0% w/w, as revealed by oscillatory and steady-shear viscosity measurements. The differences in the solution properties of CHM and CHP reflect differences in their assembly on the molecular level, in particular, the size and number of hydrophobic nanodomains and the hydration level. They are attributed to differences in the mobility of the cholesteryl groups which, itself, can be traced to the fact that in CHM the cholesteryl groups are predominantly linked to short oligomannopyranose branches, whereas in CHP they are linked to the polymer main chain. Our study provides a novel means to nanoengineer polysaccharide nanogels which may find unique biotechnological applications.

U.S. DOE Southeast Clean Energy Application Center

DOE Office of Scientific and Technical Information (OSTI.GOV)

Panzarella, Isaac; Mago, Pedro; Kalland, Stephen

2013-12-31

Between 2010 and 2013, the U.S. Department of Energy (DOE) funded the Southeast Clean Energy Application Center (SE-CEAC), co-located at the North Carolina Solar Center at NC State University (NCSU) and at Mississippi State University. The SE-CEAC was one of eight regional CEACs established to promote and assist in transforming the market for combined heat and power (CHP), district energy (DE) and waste heat to power (WHP) throughout the U.S. CHP locates power generation at the point of demand and makes productive use of the residual thermal energy for process and space heating in factories and businesses, thus lowering themore » cost of meeting electricity and heat requirements and increasing energy efficiency. The overall goal of the SE-CEAC was to support end-user implementation and overall market transformation for CHP and related clean energy technologies. Five objectives were targeted to achieve the goal: 1. Market Analysis and Information Dissemination 2. Outreach and Education for Potential CHP End-users 3. Policy Support for State and Regional Stakeholders 4. Technical Assistance to Support CHP Deployment 5. Collaboration with DOE and other CEACs Throughout the project, the CEACs provided key services of education and outreach, technical assistance and market analysis in support of project objectives. These services were very effective at achieving key objectives of assisting prospective CHP end-users and informing policy makers, utilities and others about the benefits of CHP. There is a marked increase in the awareness of CHP technologies and applications as an energy resource among end-users, policymakers, utility regulators, electric utilities and natural gas utilities in the Southeast region as a result. At the end of 2013, a number of best-practice policies for CHP were applied or under consideration in various Southeast states. The SE-CEAC met its targets for providing technical assistance with over 50 analyses delivered for 412 MW of potential end-users CHP applications. Of these 50 MW of projects were under consideration at the end of 2013 based on SE-CEAC technical assistance findings.« less

Calcineurin homologous protein as an essential cofactor for Na+/H+ exchangers.

PubMed

Pang, T; Su, X; Wakabayashi, S; Shigekawa, M

2001-05-18

The Na+/H+ exchangers (NHEs) comprise a family of transporters that catalyze cell functions such as regulation of the pH and volume of a cell and epithelial absorption of Na+ and bicarbonate. Ubiquitous calcineurin B homologous protein (CHP or p22) is co-localized and co-immunoprecipitated with expressed NHE1, NHE2, or NHE3 independently of its myristoylation and Ca2+ binding, and its binding site was identified as the juxtamembrane region within the carboxyl-terminal cytoplasmic domain of exchangers. CHP binding-defective mutations of NHE1-3 or CHP depletion by injection of the competitive CHP-binding region of NHE1 into Xenopus oocytes resulted in a dramatic reduction (>90%) in the Na+/H+ exchange activity. The data suggest that CHP serves as an essential cofactor, which supports the physiological activity of NHE family members.

The use of Chinese herbal products and its influence on tamoxifen induced endometrial cancer risk among female breast cancer patients: a population-based study.

PubMed

Tsai, Yueh-Ting; Lai, Jung-Nien; Wu, Chien-Tung

2014-09-11

The increased practice of traditional Chinese medicine (TCM) worldwide has raised concerns regarding herb-drug interactions. The purpose of our study was to analyze the use of Chinese herbal products (CHPs) and to estimate the influence of the use of CHP on tamoxifen induced endometrial cancer risk among female breast cancer patients in Taiwan. All patients newly diagnosed with invasive breast cancer receiving tamoxifen treatment from January 1, 1998 to December 31, 2008 were selected from the National Health Insurance Research Database. The usage, frequency of service, and CHPs prescribed among the 20,466 tamoxifen-treated female breast cancer patients were analyzed. The logistic regression method was employed to estimate the odds ratios (ORs) for utilization of CHPs. Cox proportional hazard regression was performed to calculate the hazard ratios (HRs) for subsequent endometrial cancer for CHP non-users and CHP users among female breast cancer patients who had undergone tamoxifen treatment. More than half of the subjects had ever used a CHP. Jia-Wei-Xiao-Yao-San (Augmented Rambling Powder) and Shu-Jing-Huo-Xue-Tang (Channel-Coursing Blood-Quickening Decoction) were the two most commonly used CHPs. The HR for the development of endometrial cancer among CHP users was 0.50-fold (95% CI=0.38-0.64) compared to that of CHP non-users. More than half of the study subjects had ever used a CHP. Jia-Wei-Xiao-Yao-San was the most commonly used CHP. Among female breast cancer patients who had undergone tamoxifen therapy, CHP consumption decreased the risk of subsequent endometrial cancer. Exploring potential Chinese herb-tamoxifen interactions and integrating both healthcare approaches are beneficial to the overall health outcomes of tamoxifen-treated female breast cancer patients. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

Antitumor effect of bevacizumab in a xenograft model of canine hemangiopericytoma.

PubMed

Michishita, Masaki; Uto, Tatsuya; Nakazawa, Ryota; Yoshimura, Hisashi; Ogihara, Kikumi; Naya, Yuko; Tajima, Tsuyoshi; Azakami, Daigo; Kishikawa, Seigo; Arai, Toshiro; Takahashi, Kimimasa

2013-01-01

Canine hemangiopericytoma (CHP) is characterized by frequent local recurrence and increased invasiveness. Vascular endothelial growth factor (VEGF) is a key regulator of angiogenesis in tumors. The aim of the present study was to investigate the effect of a single dose of bevacizumab on a xenograft model of CHP. VEGF protein was secreted from cultured CHP cells and interacted with bevacizumab. Bevacizumab treatment suppressed tumor growth by inhibiting tumor angiogenesis, whereas no significant differences were observed in the proliferation index and apoptosis rates of treated and untreated mice. Thus, bevacizumab had antitumor effects in a xenograft model of CHP.

Benefices environnementaux de la cogeneration d'energie en milieu hospitalier et cas de l'Hopital de Moncton

NASA Astrophysics Data System (ADS)

Kone, Diakalia

The present study aimed at assessing the environmental benefits of power management practices based on cogeneration in the particular industrial sector of hospitals and healthcare. Cogeneration power systems, also known as "Combined Heat and Power" (CHP) or Cogen, supply on-site electricity and heat from a single fuel source (natural gas in general). While the efficiency of conventional plants to produce power and heat separately is limited to about 30%, the efficiency of a CHP plant is close to 80% and can reach up to 90% in some applications (Borbely et Kreider, 2001). One of the distinctive features of hospitals is their continuous demand for both type of energy (electricity and heat), which makes them good candidate for cogeneration. However, in North America at the present time, less than 5% of hospitals run on CHP. Most are being supplied with electricity by conventional power plants, run by specialized companies, and use on-site boiler(s) to generate heat. Energy spending can reach up to 3% of an hospital's annual operational budget. There are also environmental impacts related to current energy supply and use in hospitals. For instance, the burning of fossil fuels releases greenhouse gases (GHG), which contribute to human health problems and climate change. The first objective of the study was to outline the main benefits and challenges faced by hospitals that aim at becoming their own energy co-generator, in comparison to having power and heat produced separately. Our second objective was to assess prospectively (proactively) the environmental impacts of a cogeneration plant that is being planned, but not yet operated, in a Canadian hospital. The methodology was based on literature reviews and on a case study, namely that of The Moncton Hospital (TMH)/L'Hopital de Moncton, Moncton, New Brunswick, Canada. This hospital is considered a large hospital with 375 beds and a major and expanding ambulatory care service. It is also in the process of developing a 1.06 MW cogeneration plant, to be run on natural gas, to meet about 30% of the facility's current demand for electricity and heat. In order to anticipate the environmental consequences of this CHP project, an environmental impact assessment (EIA) was conducted, according to the principles that apply in New Brunswick (Regulation 87-83 on EIA). A literature review was conducted and a matrix approach (matrix of impacts) was used to identify and assess the anticipated environmental impacts. The study showed that multiple stakeholders in the healthcare sector can reap benefits of CHP deployment. Facility owners can reduce energy costs and increase power reliability to enhance operations' continuity, during normal and extraordinary times (e.g., natural disasters). For instance, when hurricanes Katrina and Rita struck the United States in 2005, hospitals running with CHP were able to provide secure electricity supplies for emergency facilities and shelters. CHP also has environmental benefits related to its distinctively high efficiency. But its deployment in the healthcare sector also provides challenges, mainly due to the fact that power production is not a core activity for an hospital. These challenges can be overcome, however, as shown by numerous success stories in hospitals worldwide; specialised resources are available to help hospitals switch to CHP. This study underlines some of the steps a hospital can take toward this aim. EIA of The Moncton Hospital CHP project suggests that, globally, the environmental impacts of CHP are reduced compared to the traditional production of electricity and heat separately. Cogeneration utilizes fewer resources (fuel) and therefore releases fewer GHG and other pollutants. However, quantifying the emissions avoided is challenging. Also, the environmental benefits of CHP may be less obvious when compared to a centralised nuclear or hydraulic power production, which emits less GHG than power plants operating on coal or fuel oil. The study also indicates that other conditions are required to increase the environmental gains that can be expected from CHP deployment in the hospital sector. These conditions include the use of renewable fuel sources (biomass), the development of well-structured frameworks (e.g., efficient environmental management systems) to coordinate and leverage environmental stewardship initiatives within hospitals, and the development of energy partnerships (e.g., municipal heat networks). A broad, eco-systemic vision, like the one of industrial ecology, would help strengthen the ecological benefits of cogeneration in the hospital and health care sector. Key Words Heat and power cogeneration, hospitals, benefits/challenges, environment, society, environmental impact assessment, Canada, sustainable development, industrial ecology.

Promoting active transportation as a partnership between urban planning and public health: the columbus healthy places program.

PubMed

Green, Christine Godward; Klein, Elizabeth G

2011-01-01

Active transportation has been considered as one method to address the American obesity epidemic. To address obesity prevention through built-environment change, the local public health department in Columbus, Ohio, established the Columbus Healthy Places (CHP) program to formally promote active transportation in numerous aspects of community design for the city. In this article, we present a case study of the CHP program and discuss the review of city development rezoning applications as a successful strategy to link public health to urban planning. Prior to the CHP review, 7% of development applications in Columbus included active transportation components; in 2009, 64% of development applications adopted active transportation components specifically recommended by the CHP review. Active transportation recommendations generally included adding bike racks, widening or adding sidewalks, and providing sidewalk connectivity. Recommendations and lessons learned from CHP are provided.

Promoting Active Transportation as a Partnership Between Urban Planning and Public Health: The Columbus Healthy Places Program

PubMed Central

Green, Christine Godward; Klein, Elizabeth G.

2011-01-01

Active transportation has been considered as one method to address the American obesity epidemic. To address obesity prevention through built-environment change, the local public health department in Columbus, Ohio, established the Columbus Healthy Places (CHP) program to formally promote active transportation in numerous aspects of community design for the city. In this article, we present a case study of the CHP program and discuss the review of city development rezoning applications as a successful strategy to link public health to urban planning. Prior to the CHP review, 7% of development applications in Columbus included active transportation components; in 2009, 64% of development applications adopted active transportation components specifically recommended by the CHP review. Active transportation recommendations generally included adding bike racks, widening or adding sidewalks, and providing sidewalk connectivity. Recommendations and lessons learned from CHP are provided. PMID:21563711

Projected configuration of a coal-fired district heating source on the basis of comparative technical-economical optimization analysis

NASA Astrophysics Data System (ADS)

Tańczuk, Mariusz; Radziewicz, Wojciech; Olszewski, Eligiusz; Skorek, Janusz

2017-10-01

District heating technologies should be efficient, effective and environmentally friendly. The majority of the communal heating systems in Poland produce district hot water in coal-fired boilers. A large number of them are considerably worn out, low-efficient in the summer time and will not comply with forthcoming regulations. One of the possible solution for such plants is repowering with new CHP systems or new boilers fuelled with fuels alternative to coal. Optimisation analysis of the target configuration of municipal heat generating plant is analysed in the paper. The work concerns repowering the existing conventional heat generating plant according to eight different scenarios of the plant configuration meeting technical and environmental requirements forecasted for the year of 2035. The maximum demand for heat of the system supplied by the plant is 185 MW. Taking into account different technical configurations on one side, and different energy and fuel prices on the other side, the comparative cost-benefits analysis of the assumed scenarios has been made. The basic economical index NPV (net present value) has been derived for each analysed scenario and the results have been compared and discussed. It was also claimed that the scenario with CHP based on ICE engines is optimal.

A Pilot Evaluation of Small Group Challenging Horizons Program (CHP): A Randomized Trial

ERIC Educational Resources Information Center

Langberg, Joshua M.; Smith, Bradley H.; Bogle, Kristin E.; Schmidt, Jonathan D.; Cole, Wesley R.; Pender, Carolyn A. S.

2007-01-01

This study examined the efficacy of an after-school program, the Challenging Horizons Program (CHP), that met four days a week and focused on improving organization, academic skills, and classroom behavior. The CHP was compared with a community control that included involvement in a district-run after-school program that met one to three days a…

Self-assembled pH-sensitive cholesteryl pullulan nanogel as a protein delivery vehicle.

PubMed

Morimoto, Nobuyuki; Hirano, Sayaka; Takahashi, Haruko; Loethen, Scott; Thompson, David H; Akiyoshi, Kazunari

2013-01-14

A self-assembled nanogel, derived from an acid-labile cholesteryl-modified pullulan (acL-CHP), was prepared by grafting vinyl ether-cholesterol substituents onto a 100 kD pullulan main chain polymer backbone. Stable nanogels are formed by acL-CHP self-assemblies at neutral pH. The hydrodynamic radius of the nanogels, observed to be 26.5 ± 5.1 nm at pH 7.0, increased by ~135% upon acidification of the solution to pH 4.0. SEC analysis of the acL-CHP nanogel at pH 4.0 showed that the grafts were nearly 80% degraded after 24 h, whereas little or no degradation was observed over the same time period for a pH stable analog (acS-CHP) at pH 4.0 or the acL-CHP at pH 7.0. Complexation of BSA with the acL-CHP nanogel was observed at pH 7.0 with subsequent release of the protein upon acidification. These findings suggest that stimuli-responsive, self-assembled nanogels can release protein cargo in a manner that is controlled by the degradation rate of the cholesterol-pullulan grafting moiety.

Analysis of cellular and protein content of broncho-alveolar lavage fluid from patients with idiopathic pulmonary fibrosis and chronic hypersensitivity pneumonitis.

PubMed Central

Reynolds, H Y; Fulmer, J D; Kazmierowski, J A; Roberts, W C; Frank, M M; Crystal, R G

1977-01-01

To evaluate cellular and protein components in the lower respiratory tract of patients with idiopathic pulmonary fibrosis (IPF) and chronic hypersensitivity pneumonitis (CHP), limited broncho-alveolar lavage was done in 58 patients (19 IPF, 7 CHP, and 32 controls). Analysis of the cells and protein in the lavage fluids from patients with IPF revealed an inflammatory and eosinophilic response and a significant elevation of IgG in the lungs. With corticosteroid therapy, inflammation diminished but eosinophils remained. Lavage fluid from patients with CHP also had eosinophils and elevated levels of IgG. However, in contrast to IPF, lavage fluid from CHP patients contained IgM, fewer inflammatory cells, and a strikingly increased number (38-74%) of lymphocytes. Identification of lavage lymphocytes in CHP showed that T lymphocytes were significantly elevated and B lymphocytes were decreased compared to peripheral blood. These studies suggest nthat the lung in IPF and CHP may function as a relatively independent immune organ, and that analysis of cells and proteins in broncho-alveolar lavage fluid may be of diagnostic, therapeutic, and investigative value in evaluating patients with fibrotic lung disease. PMID:830661

Diabetes may affect the expression of matrix metalloproteinases and their inhibitors more than smoking in chronic periodontitis.

PubMed

Bastos, M F; Tucci, M A; de Siqueira, A; de Faveri, M; Figueiredo, L C; Vallim, P C; Duarte, P M

2017-04-01

No previous study has directly compared the levels of matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinases (TIMPs) between smokers and individuals with diabetes mellitus (DM) with periodontitis. Therefore, the aim of this study was to evaluate the gene expression of MMP-1, MMP-2, MMP-8, MMP-9, TIMP-1 and TIMP-2 in tissues with chronic periodontitis (ChP) of smokers and individuals with type 2 DM. Gingival biopsies were harvested from: non-smokers and non-diabetic individuals with ChP (n = 18) (ChP group); non-diabetic smokers (≥ 10 cigarettes per day for at least the past 5 years) with ChP (n = 18) (SChP group); non-smoking individuals with type 2 diabetes (glycated hemoglobin levels ≥ 7.5%) and ChP (n = 18) (DMChP group). The tissue levels of mRNA of MMP-1, MMP-2, MMP-8, MMP-9, TIMP-1 and TIMP-2 were evaluated by quantitative real-time polymerase chain reaction. The MMP-8 expression was the lowest in the ChP group (p < 0.05). The DMChP group presented increased mRNA levels of MMP-2 and MMP-9, when compared to the SChP group (p < 0.05). MMP-1 expression and the MMP-1/TIMP-1, MMP-2/TIMP-1, MMP-8/TIMP-1, MMP-9/TIMP-1, MMP-1/TIMP-2 and MMP-2/TIMP-2 ratios were higher in the DMChP group than in the ChP and SChP groups (p < 0.05). The DMChP group presented lower mRNA levels of TIMP-1 than the ChP group (p < 0.05). The MMP-8/TIMP-2 ratio was the highest in the SChP group (p < 0.05). Uncontrolled type 2 DM upregulates the ratio of MMP/TIMPs in sites with ChP more than smoking, which may contribute to a greater extracellular matrix degradation and periodontal breakdown in DM-related periodontitis. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

USAF Dehumidification Efforts for Corrosion Control

DTIC Science & Technology

2011-08-16

Stored AGE Renewable energy powers dehumidification equipment (DH) DH maintains dry air in storage booths, protecting AGE equipment from...lighting also powered by renewable energy 11 CHP Shelters • Used to prevent corrosion on outer skin • Being developed for the F-22 at...DH can be Sheltered or Unsheltered • Air Dehydration Units - Uses a self rejuvenating desiccant wheel dehumidifier - Closed or open loop

Procuring Stationary Fuel Cells For CHP: A Guide for Federal Facility Decision Makers

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stinton, David P; McGervey, Joseph; Curran, Scott

2011-11-01

Federal agency leaders are expressing growing interest in using innovative fuel cell combined heat and power (CHP) technology at their sites, motivated by both executive branch sustainability targets and a desire to lead by example in the transition to a clean energy economy. Fuel cell CHP can deliver reliable electricity and heat with 70% to 85% efficiency. Implementing this technology can be a high efficiency, clean energy solution for agencies striving to meet ambitious sustainability requirements with limited budgets. Fuel cell CHP systems can use natural gas or renewable fuels, such as biogas. Procuring Stationary Fuel Cells for CHP: Amore » Guide for Federal Facility Decision Makers presents an overview of the process for planning and implementing a fuel cell CHP project in a concise, step-by-step format. This guide is designed to help agency leaders turn their interest in fuel cell technology into successful installations. This guide concentrates on larger (100 kW and greater) fuel cell CHP systems and does not consider other fuel cell applications such as cars, forklifts, backup power supplies or small generators (<100 kW). Because fuel cell technologies are rapidly evolving and have high up front costs, their deployment poses unique challenges. The electrical and thermal output of the CHP system must be integrated with the building s energy systems. Innovative financing mechanisms allow agencies to make a make versus buy decision to maximize savings. This guide outlines methods that federal agencies may use to procure fuel cell CHP systems with little or no capital investment. Each agency and division, however, has its own set of procurement procedures. This guide was written as a starting point, and it defers to the reader s set of rules if differences exist. The fuel cell industry is maturing, and project developers are gaining experience in working with federal agencies. Technology improvements, cost reductions, and experienced project developers are making fuel cell projects easier to put into service. In this environment, federal decision makers can focus on being smart buyers of fuel cell energy instead of attempting to become experts in fuel cell technology. For agencies that want to pursue a fuel cell CHP this guide presents a four step process for a successful project. 1. Perform a preliminary screening of the energy needs energy costs and incentives. 2. Compare a detailed project plan. 3. Make a financing and contracting decision. 4. Execute the project plan including financing, installation, and operation. The simplest procurement method is designated funding for the outright purchase of the fuel cell CHP system, although this is usually not the most cost-effective option. This guide describes the following financing options: Power purchase agreement Energy savings performance contract Utility energy services contract Enhanced use lease Fuel cell CHP technology can help federal facility managers comply with agency objectives for reducing energy consumption and air pollution emissions. Fuel cells do not generate particulate pollutants, unburned hydrocarbons or the gases that produce acid rain. Fuel cells emit less carbon dioxide (CO2) than other, less efficient technologies and use of renewable fuels can make them carbon neutral. Fuel cell CHP technology can deliver reliable electricity and heat with high efficiency (70% to 85%) in a small physical footprint with little noise, making it a cost-effective option for federal facilities.« less

CHP dominates Dutch energy plans

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jeffs, E.

For much of the last fifteen years, the Netherlands has been the main market for industrial CHP schemes, thanks to an enlightened program of legislation which has placed emphasis on energy efficiency and rational use of indigenous natural gas reserves. Since 1980, district heating in the Netherlands has been essentially confined to new housing developments and large institutional heat consumers in existing cities. Today a system of capital grants for CHP has stimulated a new wave of much larger industrial CHP schemes in which the utilities are coming in as joint venture partners with a designated steam host. In factmore » the government is unwittingly dictating the design of the plants, since to qualify for grant aid, the proposed plant must have an overall efficiency of at least 60%, and the higher the value the bigger the grant. The major beneficiary in the current round of orders for CHP schemes has been ABB STAL with their 25-MW Type GT 10. 3 figs., 1 tab.« less

Field Demonstration, Optimization, and Rigorous Validation of Peroxygen-Based ISCO for the Remediation of Contaminated Groundwater - CHP Stabilization Protocol

DTIC Science & Technology

2014-05-01

propagations CoCs Contaminants of concern GC Gas chromatography DNAPL Dense nonaqueous phase liquid ISCO In situ chemical oxidation HCA...used for the design and scale-up of air strippers, ion exchange systems, precipitation reactors , and many other treatment processes. Such treatability...studies provide definitive data on system dimensions and reagent dosages using linear or non -linear scale-up. Designing these processes without the

Biomass CHP Catalog of Technologies

EPA Pesticide Factsheets

This report reviews the technical and economic characterization of biomass resources, biomass preparation, energy conversion technologies, power production systems, and complete integrated CHP systems.

Dermal Exposure to Cumene Hydroperoxide: Assessing its Toxic Relevance and Oxidant Potential

PubMed Central

Rider, Cynthia V.; Chan, Po; Herbert, Ron A.; Kissling, Grace E.; Fomby, Laurene M.; Hejtmancik, Milton R.; Witt, Kristine; Waidyanatha, Suramya; Travlos, Greg; Kadiiska, Maria B.

2016-01-01

Cumene hydroperoxide (CHP) is a high production volume chemical that is used to generate phenol and acetone. Dermal exposure to CHP was hypothesized to result in systemic tissue toxicity, production of free radicals and consequent decrease of plasma antioxidant levels. To evaluate the hypothesis and characterize the toxicity of CHP, male and female B6C3F1/N mice and F344/N rats were exposed to varying doses of CHP applied topically for 14 or 90 days. No significant changes in survival or body weight of mice and rats were observed following 14 days of exposure. However, 90 days of CHP exposure at the high dose (12 mg/kg) triggered a significant decrease (−15%) in the body weight of the male rat group only. Irritation of the skin was observed at the site of application and was characterized by inflammation and epidermal hyperplasia. In treated animals, histology of liver tissue, free radical generation, and antioxidant levels in blood plasma were not significantly changed as compared to the corresponding controls. Consistent with the lack of systemic damage, no increase in micronucleated erythrocytes was seen in peripheral blood. In conclusion, topical CHP application caused skin damage only at the application site and did not cause systemic tissue impairment. PMID:26985019

Deployment of FlexCHP System

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cygan, David

The Gas Technology Institute (GTI), along with its partner Integrated CHP Systems Corporation, has developed and demonstrated an Ultra-Low-Nitrogen Oxide (ULN) Flexible Combined Heat and Power (FlexCHP) system that packages a state-of-the-art Capstone C65 gas microturbine and Johnston PFXX100 boiler with an innovative natural gas-fired supplemental burner. Supplemental burners add heat as needed in response to facility demand, which increases energy efficiency, but typically raises exhaust NOx levels, degrading local air quality unless a costly and complicated catalytic treatment system is added. The FlexCHP system increases energy efficiency and achieves the 2007 California Air Resource Board (CARB) distributed generation emissionsmore » standards for Nitrogen oxides (NOx), Carbon Monoxide (CO), and Total Hydrocarbons (THC) without catalytic exhaust gas treatment. The key to this breakthrough performance is a simple and reliable burner design which utilizes staged combustion with engineered internal recirculation. This ULN burner system successfully uses turbine exhaust as an oxidizer, while achieving high efficiencies and low emissions. In tests at its laboratory facilities in Des Plaines, Illinois, GTI validated the ability of the system to achieve emissions of NOx, CO, and THC below the CARB criteria of 0.07, 0.10, and 0.02 lb/MW-h respectively. The FlexCHP system was installed at the field demonstration site, Inland Empire Foods, in Riverside, California to verify performance of the technology in an applied environment. The resulting Combined Heat and Power (CHP) package promises to make CHP implementation more attractive, mitigate greenhouse gas emissions, and improve the reliability of electricity supply.« less

Life-Cycle Analysis of Greenhouse Gas Emissions and Water Consumption – Effects of Coal and Biomass Conversion to Liquid Fuels as Analyzed with the GREET Model

DOE Office of Scientific and Technical Information (OSTI.GOV)

Li, Qianfeng; Cai, Hao; Han, Jeongwoo

The vast reserves of coal in the U.S. provide a significant incentive for the development of processes for coal conversion to liquid fuels (CTL). Also, CTL using domestic coal can help move the U.S. toward greater energy independence and security. However, current conversion technologies are less economically competitive and generate greater greenhouse gas (GHG) emissions than production of petroleum fuels. Altex Technologies Corporation (Altex, hereinafter) and Pennsylvania State University have developed a hybrid technology to produce jet fuel from a feedstock blend of coal and biomass. Collaborating with Altex, Argonne National Laboratory has expanded and used the Greenhouse gases, Regulatedmore » Emissions, and Energy use in Transportation (GREET®) model to assess the life-cycle GHG emissions and water consumption of this hybrid technology. Biomass feedstocks include corn stover, switchgrass, and wheat straw. The option of biomass densification (bales to pellets) is also evaluated in this study. The results show that the densification process generates additional GHG emissions as a result of additional biomass process energy demand. This process coproduces a large amount of char, and this study investigates two scenarios to treat char: landfill disposal (Char-LF) and combustion for combined heat and power (CHP). Since the CHP scenarios export excess heat and electricity as coproducts, two coproduct handling methods are used for well-to-wake (WTWa) analysis: displacement (Char-CHP-Disp) and energy allocation (Char-CHP-EnAllo). When the feedstock contains 15 wt% densified wheat straw and 85 wt% lignite coal, WTWa GHG emissions of the coal-and-biomass-to-liquid pathways are 116, 97, and 137 gCO2e per megajoule (MJ) under the Char-LF, Char-CHP-Disp, and Char-CHP-EnAllo scenarios, respectively, as compared to conventional jet fuel production at 84 gCO2e/MJ. WTWa water consumption values are 0.072, -0.046, and 0.044 gal/MJ for Char-LF, Char-CHP-Disp, and Char-CHP-EnAllo, respectively, as compared to conventional jet fuel production at 0.028 gal/MJ. To reach the break-even point of 84 gCO2e/MJ, under the assumptions of constant product yields and energy demands regardless of the share of biomass and coal feedstocks, 31 wt%, 23 wt%, and 53 wt% of the feedstock blend need to be biomass under the Char-LF, Char-CHP-Disp, and Char-CHP-EnAllo scenarios, respectively.« less

THE CO2 ABATEMENT POTENTIAL OF CALIFORNIA'S MID-SIZED COMMERCIAL BUILDINGS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stadler, Michael; Marnay, Chris; Cardoso, Goncalo

2009-12-31

The Ernest Orlando Lawrence Berkeley National Laboratory (LBNL) is working with the California Energy Commission (CEC) todetermine the potential role of commercial sector distributed generation (DG) with combined heat and power (CHP) capability deployment in greenhouse gas emissions (GHG) reductions. CHP applications at large industrial sites are well known, and a large share of their potential has already been harvested. In contrast, relatively little attention has been paid to the potential of medium-sized commercial buildings, i.e. ones with peak electric loads ranging from 100 kW to 5 MW. We examine how this sector might implement DG with CHP in costmore » minimizing microgrids that are able to adopt and operate various energy technologies, such as solar photovoltaics (PV), on-site thermal generation, heat exchangers, solar thermal collectors, absorption chillers, and storage systems. We apply a mixed-integer linear program (MILP) that minimizes a site?s annual energy costs as its objective. Using 138 representative mid-sized commercial sites in California (CA), existing tariffs of three major electricity distribution ultilities, and performance data of available technology in 2020, we find the GHG reduction potential for this CA commercial sector segment, which represents about 35percent of total statewide commercial sector sales. Under the assumptions made, in a reference case, this segment is estimated to be capable of economically installing 1.4 GW of CHP, 35percent of the California Air Resources Board (CARB) statewide 4 GW goal for total incremental CHP deployment by 2020. However, because CARB?s assumed utilization is far higher than is found by the MILP, the adopted CHP only contributes 19percent of the CO2 target. Several sensitivity runs were completed. One applies a simple feed-in tariff similar to net metering, and another includes a generous self-generation incentive program (SGIP) subsidy for fuel cells. The feed-in tariff proves ineffective at stimulating CHP deployment, while the SGIP buy down is more powerful. The attractiveness of CHP varies widely by climate zone and service territory, but in general, hotter inlandareas and San Diego are the more attractive regions because high cooling loads achieve higher equipment utilization. Additionally, large office buildings are surprisingly good hosts for CHP, so large office buildings in San Diego and hotter urban centers emerge as promising target hosts. Overall the effect on CO2 emissions is limited, never exceeding 27 percent of the CARB target. Nonetheless, results suggest that the CO2 emissions abatement potential of CHP in mid-sized CA buildings is significant, and much more promising than is typically assumed.« less

Clean Energy Application Center

DOE Office of Scientific and Technical Information (OSTI.GOV)

Freihaut, Jim

2013-09-30

The Mid Atlantic Clean Energy Application Center (MACEAC), managed by The Penn State College of Engineering, serves the six states in the Mid-Atlantic region (Pennsylvania, New Jersey, Delaware, Maryland, Virginia and West Virginia) plus the District of Columbia. The goals of the Mid-Atlantic CEAC are to promote the adoption of Combined Heat and Power (CHP), Waste Heat Recovery (WHR) and District Energy Systems (DES) in the Mid Atlantic area through education and technical support to more than 1,200 regional industry and government representatives in the region. The successful promotion of these technologies by the MACEAC was accomplished through the followingmore » efforts; (1)The MACEAC developed a series of technology transfer networks with State energy and environmental offices, Association of Energy Engineers local chapters, local community development organizations, utilities and, Penn State Department of Architectural Engineering alumni and their firms to effectively educate local practitioners about the energy utilization, environmental and economic advantages of CHP, WHR and DES; (2) Completed assessments of the regional technical and market potential for CHP, WHR and DE technologies application in the context of state specific energy prices, state energy and efficiency portfolio development. The studies were completed for Pennsylvania, New Jersey and Maryland and included a set of incentive adoption probability models used as a to guide during implementation discussions with State energy policy makers; (3) Using the technical and market assessments and adoption incentive models, the Mid Atlantic CEAC developed regional strategic action plans for the promotion of CHP Application technology for Pennsylvania, New Jersey and Maryland; (4) The CHP market assessment and incentive adoption model information was discussed, on a continuing basis, with relevant state agencies, policy makers and Public Utility Commission organizations resulting in CHP favorable incentive programs in New Jersey, Pennsylvania, Maryland and Delaware; (5) Developed and maintained a MACEAC website to provide technical information and regional CHP, WHR and DE case studies and site profiles for use by interested stakeholders in information transfer and policy discussions; (6) Provided Technical Assistance through feasibility studies and on site evaluations. The MACEAC completed 28 technical evaluations and 9 Level 1 CHP analyses ; and (7) the MACEAC provided Technical Education to the region through a series of 29 workshops and webinars, 37 technical presentations, 14 seminars and participation in 13 CHP conferences.« less

Factors associated with public awareness of the Crown Health Program in the Al-Jouf Region.

PubMed

Memish, Ziad A; Saeedi, Mohammad Y; Al Madani, Ahmed J; Junod, Bernard; Jamo, Abdelgadier; Abid, Omer; Alanazi, Faisal M; Alrewally, Fayez G; Mandil, Ahmed M A

2015-01-01

A community-based intervention, the Crown Health Project (CHP), was developed by the Ministry of Health. It was implemented on a small-scale in Al-Jouf Region in Northern Kingdom of Saudi Arabia to assess its feasibility and effectiveness so that it can be scaled up. This study primarily aimed at investigating factors associated with the awareness of CHP in order to improve subsequent campaigns for the program in Al-Jouf and other regions. A secondary aim was to assess possible changes of public awareness during intensification of the awareness campaign between October 2011 and May 2012. A pre- and post-questionnaire cross-sectional approach was undertaken, and the intervention was an awareness campaign. Variables collected included demographic characteristics (e.g., age, gender, education, occupation, urban/rural residence) and CHP awareness (its existence, sources of knowledge about CHP, its goals and objectives, its target diseases, location of activities, participation in such activities). Logistic regression was used to analyze the awareness of the program according to participant characteristics, with a time of the survey as a variable. Awareness of the program was found to be 11 times higher among postsurvey respondents than presurvey respondents. Respondents of the second survey were better at correctly identifying "health education" as the main goal of the CHP (odds ratio [OR], 4.1; 95% confidence interval [CI], 3.1-5.5), "noncommunicable diseases" as the main diseases targeted (OR, 4.8; 95% CI, 3.6-6.4) and "attention to health" as the purpose (OR, 6.0; 95% CI, 4.0-8.9). The different activities of the CHP were successful in dramatically increasing awareness of the CHP program in Al-Jouf.

Factors associated with public awareness of the Crown Health Program in the Al-Jouf Region

PubMed Central

Memish, Ziad A.; Saeedi, Mohammad Y.; Al Madani, Ahmed J.; Junod, Bernard; Jamo, Abdelgadier; Abid, Omer; Alanazi, Faisal M.; Alrewally, Fayez G.; Mandil, Ahmed M. A.

2015-01-01

Objectives: A community-based intervention, the Crown Health Project (CHP), was developed by the Ministry of Health. It was implemented on a small-scale in Al-Jouf Region in Northern Kingdom of Saudi Arabia to assess its feasibility and effectiveness so that it can be scaled up. This study primarily aimed at investigating factors associated with the awareness of CHP in order to improve subsequent campaigns for the program in Al-Jouf and other regions. A secondary aim was to assess possible changes of public awareness during intensification of the awareness campaign between October 2011 and May 2012. Methods: A pre- and post-questionnaire cross-sectional approach was undertaken, and the intervention was an awareness campaign. Variables collected included demographic characteristics (e.g., age, gender, education, occupation, urban/rural residence) and CHP awareness (its existence, sources of knowledge about CHP, its goals and objectives, its target diseases, location of activities, participation in such activities). Logistic regression was used to analyze the awareness of the program according to participant characteristics, with a time of the survey as a variable. Results: Awareness of the program was found to be 11 times higher among postsurvey respondents than presurvey respondents. Respondents of the second survey were better at correctly identifying “health education” as the main goal of the CHP (odds ratio [OR], 4.1; 95% confidence interval [CI], 3.1–5.5), “noncommunicable diseases” as the main diseases targeted (OR, 4.8; 95% CI, 3.6–6.4) and “attention to health” as the purpose (OR, 6.0; 95% CI, 4.0–8.9). Conclusion: The different activities of the CHP were successful in dramatically increasing awareness of the CHP program in Al-Jouf. PMID:25657609

Targeting regenerative exosomes to myocardial infarction using cardiac homing peptide

PubMed Central

Vandergriff, Adam; Huang, Ke; Shen, Deliang; Hu, Shiqi; Hensley, Michael Taylor; Caranasos, Thomas G.; Qian, Li; Cheng, Ke

2018-01-01

Rationale: Cardiac stem cell-derived exosomes have been demonstrated to promote cardiac regeneration following myocardial infarction in preclinical studies. Recent studies have used intramyocardial injection in order to concentrate exosomes in the infarct. Though effective in a research setting, this method is not clinically appealing due to its invasive nature. We propose the use of a targeting peptide, cardiac homing peptide (CHP), to target intravenously-infused exosomes to the infarcted heart. Methods: Exosomes were conjugated with CHP through a DOPE-NHS linker. Ex vivo targeting was analyzed by incubating organ sections with the CHP exosomes and analyzing with fluorescence microscopy. In vitro assays were performed on neonatal rat cardiomyocytes and H9C2 cells. For the animal study, we utilized an ischemia/reperfusion rat model. Animals were treated with either saline, scramble peptide exosomes, or CHP exosomes 24 h after surgery. Echocardiography was performed 4 h after surgery and 21 d after surgery. At 21 d, animals were sacrificed, and organs were collected for analysis. Results: By conjugating the exosomes with CHP, we demonstrate increased retention of the exosomes within heart sections ex vivo and in vitro with neonatal rat cardiomyocytes. In vitro studies showed improved viability, reduced apoptosis and increased exosome uptake when using CHP-XOs. Using an animal model of ischemia/reperfusion injury, we measured the heart function, infarct size, cellular proliferation, and angiogenesis, with improved outcomes with the CHP exosomes. Conclusions: Our results demonstrate a novel method for increasing delivery of for treatment of myocardial infarction. By targeting exosomes to the infarcted heart, there was a significant improvement in outcomes with reduced fibrosis and scar size, and increased cellular proliferation and angiogenesis. PMID:29556361

[Surgical treatment of chronic pancreatitis based on classification of M. Buchler and coworkers].

PubMed

Krivoruchko, I A; Boĭko, V V; Goncharova, N N; Andreeshchev, S A

2011-08-01

The results of surgical treatment of 452 patients, suffering chronic pancreatitis (CHP), were analyzed. The CHP classification, elaborated by M. Buchler and coworkers (2009), based on clinical signs, morphological peculiarities and pancreatic function analysis, contains scientifically substantiated recommendations for choice of diagnostic methods and complex treatment of the disease. The classification proposed is simple in application and constitutes an instrument for studying and comparison of the CHP course severity, the patients prognosis and treatment.

Cholesteryl Pullulan Encapsulated TNF-α Nanoparticles Are an Effective Mucosal Vaccine Adjuvant against Influenza Virus

PubMed Central

Nagatomo, Daiki; Taniai, Madoka; Ariyasu, Harumi; Taniguchi, Mutsuko; Aga, Miho; Ariyasu, Toshio; Ohta, Tsunetaka; Fukuda, Shigeharu

2015-01-01

We encapsulated tumor necrosis factor-α (TNF-α), a major proinflammatory cytokine, into cholesteryl pullulan (CHP) to prepare TNF/CHP nanoparticles. In this report, we describe the immune-enhancing capability of the nanoparticles to act as a vaccine adjuvant. TNF/CHP nanoparticles showed excellent storage stability and enhanced host immune responses to external immunogens. The nanoparticles were effective via the nasal route of administration for inducing systemic IgG1 as well as mucosal IgA. We applied the nanoparticles in a model experimental influenza virus infection to investigate their adjuvant ability. TNF/CHP nanoparticles combined with a conventional split vaccine protected mice via nasal administration against a lethal challenge of A/PR/8/34 (H1N1) influenza virus. Mechanistic studies showed that the nanoparticles enhanced antigen uptake by dendritic cells (DCs) and moderately induced the expression of inflammation-related genes in nasopharynx lymphoid tissue (NALT), leading to the activation of both B and T cells. Preliminary safety study revealed no severe toxicity to TNF/CHP nanoparticles. Slight-to-moderate influences in nasal mucosa were observed only in the repeated administration and they seemed to be reversible. Our data show that TNF/CHP nanoparticles effectively enhance both humoral and cellular immunity and could be a potential adjuvant for vaccines against infectious diseases, especially in the mucosa. PMID:26421290

Concurrent Use of Hypnotic Drugs and Chinese Herbal Medicine Therapies among Taiwanese Adults with Insomnia Symptoms: A Population-Based Study.

PubMed

Lee, Kuei-Hua; Tsai, Yueh-Ting; Lai, Jung-Nien; Lin, Shun-Ku

2013-01-01

Background. The increased practice of traditional Chinese medicine (TCM) worldwide has raised concerns regarding herb-drug interactions. The purpose of our study is to analyze the concurrent use of Chinese herbal products (CHPs) among Taiwanese insomnia patients taking hypnotic drugs. Methods. The usage, frequency of services, and CHP prescribed among 53,949 insomnia sufferers were evaluated from a random sample of 1 million beneficiaries in the National Health Insurance Research Database. A logistic regression method was used to identify the factors that were associated with the coprescription of a CHP and a hypnotic drug. Cox proportional hazards regressions were performed to calculate the hazard ratios (HRs) of hip fracture between the two groups. Results. More than 1 of every 3 hypnotic users also used a CHP concurrently. Jia-Wei-Xiao-Yao-San (Augmented Rambling Powder) and Suan-Zao-Ren-Tang (Zizyphus Combination) were the 2 most commonly used CHPs that were coadministered with hypnotic drugs. The HR of hip fracture for hypnotic-drug users who used a CHP concurrently was 0.57-fold (95% CI = 0.47-0.69) that of hypnotic-drug users who did not use a CHP. Conclusion. Exploring potential CHP-drug interactions and integrating both healthcare approaches might be beneficial for the overall health and quality of life of insomnia sufferers.

CHP Partnership Partners

EPA Pesticide Factsheets

Partners of EPA's Combined Heat and Power Partnership include federal, state, and local government agencies and private organizations such as energy users, energy service companies, CHP project developers and consultants, and equipment manufacturers.

Catching Fire: An Analysis of Maine's Combined Heat and Power Energy Incentive Policies

NASA Astrophysics Data System (ADS)

Laufer, Joshua A.

This study qualitatively reviews and analyzes Maine's state-level incentive policies and regulations to catalyze the development of renewably fueled Combined Heat and Power (CHP) facilities by utilizing a framework developed by Janet Sawin. The results of the analysis indicate that additional opportunities exist to promote additional renewable CHP plant development through both strengthening existing state policies and passing new legislation. Maine's Renewable Portfolio Standard and Production-Based Incentive pilot program could be expanded in scope and in their level of support for renewable CHP. New policies could be enacted to further accelerate renewable CHP development in the state, such as a Production Tax Credit (PTC) and the creation of a grant program for level 2 feasibility studies within the existing Public Benefits Fund (PBF), Efficiency Maine Trust.

The CO2 Reduction Potential of Combined Heat and Power in California's Commercial Buildings

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stadler, Michael; Marnay, Chris; Cardoso, Goncalo

2009-11-16

The Ernest Orlando Lawrence Berkeley National Laboratory (LBNL) is working with the California Energy Commission (CEC) to determine the potential role of commercial sector distributed generation (DG) with combined heat and power (CHP) capability deployment in greenhouse gas emissions (GHG) reductions. CHP applications at large industrial sites are well known, and a large share of their potential has already been harvested. In contrast, relatively little attention has been paid to the potential of medium-sized commercial buildings, i.e., ones with peak electric loads ranging from 100 kW to 5 MW. We examine how this sector might implement DG with CHP inmore » cost minimizing microgrids that are able to adopt and operate various energy technologies, such as solar photovoltaics (PV), on-site thermal generation, heat exchangers, solar thermal collectors, absorption chillers, and storage systems. We apply a mixed-integer linear program (MILP) that minimizes a site's annual energy costs as its objective. Using 138 representative mid-sized commercial sites in California (CA), existing tariffs of three major electricity distribution ultilities plus a natural gas company, and performance data of available technology in 2020, we find the GHG reduction potential for this CA commercial sector segment, which represents about 35percent of total statewide commercial sector sales. Under the assumptions made, in a reference case, this segment is estimated to be capable of economically installing 1.4 GW of CHP, 35percent of the California Air Resources Board (CARB) statewide 4 GW goal for total incremental CHP deployment by 2020. However, because CARB's assumed utilization is far higherthan is found by the MILP, the adopted CHP only contributes 19percent of the CO2 target. Several sensitivity runs were completed. One applies a simple feed-in tariff similar to net metering, and another includes a generous self-generation incentive program (SGIP) subsidy for fuel cells. The feed-in tariff proves ineffective at stimulating CHP deployment, while the SGIP buy down is more powerful. The attractiveness of CHP varies widely by climate zone and service territory, but in general, hotter inland areas and San Diego are the more attractive regions because high cooling loads achieve higher equipment utilization. Additionally, large office buildings are surprisingly good hosts for CHP, so large office buildings in San Diego and hotter urban centers emerge as promising target hosts. Overall the effect on CO2 emissions is limited, never exceeding 27percent of the CARB target. Nonetheless, results suggest that the CO2 emissions abatement potential of CHP in mid-sized CA buildings is significant, and much more promising than is typically assumed.« less

Financing CHP Projects at Wastewater Treatment Facilities with Clean Water State Revolving Funds

EPA Pesticide Factsheets

This factsheet provides information about CHP at wastewater treatment facilities, including applications, financial challenges, and financial opportunities, such as the Clean Water State Revolving Fund.

The Potential of Combined Heat and Power Generation, Wind Power Generation and Load Management Techniques for Cost Reduction in Small Electricity Supply Systems.

NASA Astrophysics Data System (ADS)

Bass, Jeremy Hugh

Available from UMI in association with The British Library. Requires signed TDF. An evaluation is made of the potential fuel and financial savings possible when a small, autonomous diesel system sized to meet the demands of an individual, domestic consumer is adapted to include: (1) combined heat and power (CHP) generation, (2) wind turbine generation, (3) direct load control. The potential of these three areas is investigated by means of time-step simulation modelling on a microcomputer. Models are used to evaluate performance and a Net Present Value analysis used to assess costs. A cost/benefit analysis then enables those areas, or combination of areas, that facilitate and greatest savings to be identified. The modelling work is supported by experience gained from the following: (1) field study of the Lundy Island wind/diesel system, (2) laboratory testing of a small diesel generator set, (3) study of a diesel based CHP unit, (4) study of a diesel based direct load control system, (5) statistical analysis of data obtained from the long-term monitoring of a large number of individual household's electricity consumption. Rather than consider the consumer's electrical demand in isolation, a more flexible approach is adopted, with consumer demand being regarded as the sum of primarily two components: a small, electricity demand for essential services and a large, reschedulable demand for heating/cooling. The results of the study indicate that: (1) operating a diesel set in a CHP mode is the best strategy for both financial and fuel savings. A simple retrofit enables overall conversion efficiencies to be increased from 25% to 60%, or greater, at little cost. (2) wind turbine generation in association with direct load control is a most effective combination. (3) a combination of both the above areas enables greatest overall financial savings, in favourable winds resulting in unit energy costs around 20% of those of diesel only operation.

Portfolio Standards and the Promotion of Combined Heat And Power

EPA Pesticide Factsheets

This paper presents the basic portfolio standard design approaches, identifies key CHP-related issues for policymakers to consider, and provides state-specific information on existing standards allowing for CHP.

Output-Based Regulations: A Handbook for Air Regulators

EPA Pesticide Factsheets

This handbook assists air regulators in developing emission regulations that recognize the pollution prevention benefits of CHP, and to assist CHP project owners in understanding and complying with output-based environmental regulations.

Value impact assessment: A preliminary assessment of improvement opportunities at the Quantico Central Heating Plant

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brambley, M.R.; Weakley, S.A.

1990-09-01

This report presents the results of a preliminary assessment of opportunities for improvement at the US Marine Corps (USMC) Quantico, Virginia, Central Heating Plant (CHP). This study is part of a program intended to provide the CHP staff with a computerized Artificial Intelligence (AI) decision support system that will assist in a more efficient, reliable, and safe operation of their plant. As part of the effort to provide the AI decision support system, a team of six scientists and engineers from the Pacific Northwest Laboratory (PNL) visited the plant to characterize the conditions and environment of the CHP. This assessmentmore » resulted in a list of potential performance improvement opportunities at the CHP. In this report, 12 of these opportunities are discussed and qualitatively analyzed. 70 refs., 7 figs., 6 tabs.« less

Non-surgical periodontal therapy decreases serum elastase levels in aggressive but not in chronic periodontitis.

PubMed

Eickholz, Peter; Siegelin, Yasemin; Scharf, Susanne; Schacher, Beate; Oremek, Gerhard M; Sauer-Eppel, Hildegund; Schubert, Ralf; Wohlfeil, Martin

2013-04-01

Assessment of the effect of non-surgical periodontal therapy (SRP) on serum inflammatory parameters in patients with untreated aggressive (AgP) and chronic (ChP) periodontitis. Overall, 31 ChP and 29 AgP were examined clinically prior to and 12 weeks after SRP (subgingival scaling of all pockets within 2 days) with systemic antibiotics for patients positive for Aggregatibacter actinomycetemcomitans (14 AgP, 9 ChP). Blood was sampled prior to, one day, 6, and 12 weeks after the first SRP visit. Serum elastase, C-reactive protein (CRP), lipopolysaccharide-binding protein (LBP), interleukin (IL) 6, 8, and leukocyte counts were assessed. At baseline, serum elastase, CRP, and LBP were significantly (p < 0.01) higher in AgP than ChP. Serum elastase, CRP, LBP, and IL-6 were significantly (p < 0.001) elevated one day after scaling in both groups. Both groups showed significant clinical improvement (p < 0.001). A significant difference was observed regarding change of serum elastase 12 weeks after SRP between AgP and ChP (p = 0.015). Multiple regression analysis revealed AgP, African origin, and bleeding on probing to be associated with more pronounced elastase reduction. CRP reduction was associated with African origin, systemic antibiotics, and baseline probing pocket depth. SRP results in serum elastase reduction in AgP but not in ChP. © 2013 John Wiley & Sons A/S.

Time-dependent movement and distribution of chlorothalonil and chlorpyrifos in tomatoes.

PubMed

Wang, Zhi-Wei; Huang, Jiexun; Chen, Jin-Yuan; Li, Fei-Li

2013-07-01

Determining the distribution of pesticides in fruits is essential to eliminate pesticide residues during food processing. In this study, the dynamic distribution of two pesticides, chlorothalonil (CHT) and chlorpyrifos (CHP), were determined in different tomato parts following immersion in pesticide solutions. The concentrations of CHT and CHP in tomato followed an order of cuticle>plasma>pulp. However, the plasma initially accumulated the highest pesticide concentration. And the ratio of CHT concentration to that of CHP in plasma was about 2.1:1, similar to the ratio in solution, which suggested carpopodium as the entry site for the pesticides tested. The ratio in the cuticle was 0.02:1-0.06:1. This was consistent with the ratio of Kow for the two pesticides, manifesting the direct pesticide transfer from solution to cuticle. Following pesticide injection into tomato, the degradation of CHT over 96h was described by a first-order decay equation, Ctomato(t)CHT=C0×e(-0.0239t). The CHP concentration in tomato remained nearly constant with little degradation detected. Deducting the amount of degradation and migration, volatilization appeared to contribute the most amount of migration of CHT and CHP in tomato. Copyright © 2013 Elsevier Inc. All rights reserved.

Utility Incentives for Combined Heat and Power

EPA Pesticide Factsheets

This report describes the results of EPA's research and analysis into utility incentives for CHP. It provides information about utility-initiated policies, programs, and incentives for CHP systems, and includes case studies and tools and resources.

Catalog of CHP Technologies

EPA Pesticide Factsheets

This report provides an overview of how combined heat and power systems work and the key concepts of efficiency and power-to-heat ratios. It also provides information and performance characteristics of five commercially available CHP prime movers.

Chapter 23: Combined Heat and Power Evaluation Protocol. The Uniform Methods Project: Methods for Determining Energy Efficiency Savings for Specific Measures

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kurnik, Charles W.; Simons, George; Barsun, Stephan

The main focus of most evaluations is to determine the energy-savings impacts of the installed measure. This protocol defines a combined heat and power (CHP) measure as a system that sequentially generates both electrical energy and useful thermal energy from one fuel source at a host customer's facility or residence. This protocol is aimed primarily at regulators and administrators of ratepayer-funded CHP programs; however, project developers may find the protocol useful to understand how CHP projects are evaluated.

DOE Office of Scientific and Technical Information (OSTI.GOV)

LeMar, P.

Integrated Energy Systems (IES) combine on-site power or distributed generation technologies with thermally activated technologies to provide cooling, heating, humidity control, energy storage and/or other process functions using thermal energy normally wasted in the production of electricity/power. IES produce electricity and byproduct thermal energy onsite, with the potential of converting 80 percent or more of the fuel into useable energy. IES have the potential to offer the nation the benefits of unprecedented energy efficiency gains, consumer choice and energy security. It may also dramatically reduce industrial and commercial building sector carbon and air pollutant emissions and increase source energy efficiency.more » Applications of distributed energy and Combined heat and power (CHP) in ''Commercial and Institutional Buildings'' have, however, been historically limited due to insufficient use of byproduct thermal energy, particularly during summer months when heating is at a minimum. In recent years, custom engineered systems have evolved incorporating potentially high-value services from Thermally Activated Technologies (TAT) like cooling and humidity control. Such TAT equipment can be integrated into a CHP system to utilize the byproduct heat output effectively to provide absorption cooling or desiccant humidity control for the building during these summer months. IES can therefore expand the potential thermal energy services and thereby extend the conventional CHP market into building sector applications that could not be economically served by CHP alone. Now more than ever, these combined cooling, heating and humidity control systems (IES) can potentially decrease carbon and air pollutant emissions, while improving source energy efficiency in the buildings sector. Even with these improvements over conventional CHP systems, IES face significant technological and economic hurdles. Of crucial importance to the success of IES is the ability to treat the heating, ventilation, air conditioning, water heating, lighting, and power systems loads as parts of an integrated system, serving the majority of these loads either directly or indirectly from the CHP output. The CHP Technology Roadmaps (Buildings and Industry) have focused research and development on a comprehensive integration approach: component integration, equipment integration, packaged and modular system development, system integration with the grid, and system integration with building and process loads. This marked change in technology research and development has led to the creation of a new acronym to better reflect the nature of development in this important area of energy efficiency: Integrated Energy Systems (IES). Throughout this report, the terms ''CHP'' and ''IES'' will sometimes be used interchangeably, with CHP generally reserved for the electricity and heat generating technology subsystem portion of an IES. The focus of this study is to examine the potential for IES in buildings when the system perspective is taken, and the IES is employed as a dynamic system, not just as conventional CHP. This effort is designed to determine market potential by analyzing IES performance on an hour-by-hour basis, examining the full range of building types, their loads and timing, and assessing how these loads can be technically and economically met by IES.« less

Changes in EEG power spectra and behavioral states in rats exposed to the acetylcholinesterase inhibitor chlorpyrifos and muscarinic agonist oxotremorine.

PubMed

Timofeeva, O A; Gordon, C J

2001-03-02

Organophosphates (OPs) inhibit acetylcholinesterase (AChE) activity causing cholinergic stimulation in the central nervous system (CNS). Cholinergic systems are crucial in electroencephalogram (EEG) generation and regulation of behavior; however, little is known about how OP exposure affects the EEG and behavioral states. We recorded EEG, core temperature and motor activity before and after exposure to the OP pesticide chlorpyrifos (CHP) in adult female rats implanted with telemetric transmitters. The recording and reference electrodes were placed in the occipital and frontal bones, respectively. The animals received CHP, 25 mg/kg, p.o., or oxotremorine (OX), 0.2 mg/kg, s.c. CHP led to a significant increase in delta (0.1-3.5 Hz), slow theta (4-6.5 Hz), gamma 2 (35.5-50 Hz), reduction in fast theta (7-8.5 Hz), alpha/sigma (9-14 Hz), beta 1 (14.5-24 Hz), beta 2 (24.5-30 Hz) and gamma 1 (30.5-35 Hz) powers, slowing of peak frequencies in 1-9 Hz range, hypothermia and decrease in motor activity. The drop in 7-14 Hz was associated with cholinergic suppression of sleep spindles. Changes in behavioral state were characterized by dramatic diminution of sleep postures and exploring activity and prolongation of quiet waking. There was recovery in all bands in spite of continued inhibition of AChE activity [44,45] in rats exposed to CHP. OX-induced EEG and behavioral alterations were similar to CHP except there was no increase in delta and the onset and recovery were more rapid. We did not find a correlation between the EEG and core temperature alterations. Overall, changes in EEG (except in delta band) and behavior following CHP were attributable to muscarinic stimulation. Cortical arousal together with increased quiet waking and decreased sleep after CHP occurred independently from inhibition of motor activity and lowering of core temperature.

Combined Heat and Power

EPA Pesticide Factsheets

Combined heat and power (CHP) refers to the simultaneous production of electricity and thermal energy from a single fuel source. Find out how local governments can lead by example and increase use of CHP in their facilities and their communities.

Strategic Plan Outline for the Army Utilities Modernization Program: Fiscal Years 2008-2013

DTIC Science & Technology

2006-11-01

Components of electrical demand at Fort Hood, TX........................................................109 C6 Schematics of conventional and TES cooling...feasible, should be provided to the maximum extent possible. Consideration should be given not only to conventional fuels (e.g., natural gas, propane...are lower than those of “ conventional ” units. In successful installations of CHP, the price reduction is in the range of 20-30 percent. It also

Do different probing depths exhibit striking differences in microbial profiles?

PubMed

Pérez-Chaparro, Paula Juliana; McCulloch, John Anthony; Mamizuka, Elsa Masae; Moraes, Aline da Costa Lima; Faveri, Marcelo; Figueiredo, Luciene Cristina; Duarte, Poliana Mendes; Feres, Magda

2018-01-01

To perform a thorough characterization of the subgingival microbiota of shallow, moderate and deep sites in subjects with chronic periodontitis (ChP). Subgingival samples were collected from subjects with ChP (n = 3/category of probing depth: ≤3, 4-6 and ≥7 mm) and periodontal health (PH). Individual samples were submitted to 16S rDNA high- throughput sequencing and the analysis was made using mothur and R packages. Nine subjects with ChP and seven with PH were included and 101 samples were evaluated. Thirteen phyla, 118 genera and 211 OTUs were detected. Taxa from Chloroflexi and Spirochaetes phyla were associated with initial stages of disease. Fretibacterium, Eubacterium[XI][G-6], Desulfobulbus, Peptostreptococcaceae[XI][G-1] and [G-3], Bacteroidetes[G-3], Bacteroidaceae[G-1] genera and Filifactor alocis, Fretibacterium fastidiosum, Johnsonella spHOT166, Peptostreptococcaceae[XIII][G-1]HOT113, Porphyromonas endodontalis and Treponema sp. HOT258, which are not conventionally associated with disease, increased with the deepening of the pockets and/or were elevated in ChP; while Streptococcus, Corynebacterium and Bergeyella genera were associated with PH (p < .05). Striking differences were observed between the microbiota of shallow and moderate/deep sites, but not between moderate and deep sites in ChP subjects. Differences between shallow sites in PH and ChP were also observed. The characterized microbiota included known oral microorganisms and newly identified periodontal taxa, some of them not-yet-cultured. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Oland, CB

Combined heat and power (CHP) or cogeneration is the sequential production of two forms of useful energy from a single fuel source. In most CHP applications, chemical energy in fuel is converted to both mechanical and thermal energy. The mechanical energy is generally used to generate electricity, while the thermal energy or heat is used to produce steam, hot water, or hot air. Depending on the application, CHP is referred to by various names including Building Cooling, Heating, and Power (BCHP); Cooling, Heating, and Power for Buildings (CHPB); Combined Cooling, Heating, and Power (CCHP); Integrated Energy Systems (IES), or Distributedmore » Energy Resources (DER). The principal technical advantage of a CHP system is its ability to extract more useful energy from fuel compared to traditional energy systems such as conventional power plants that only generate electricity and industrial boiler systems that only produce steam or hot water for process applications. By using fuel energy for both power and heat production, CHP systems can be very energy efficient and have the potential to produce electricity below the price charged by the local power provider. Another important incentive for applying cogeneration technology is to reduce or eliminate dependency on the electrical grid. For some industrial processes, the consequences of losing power for even a short period of time are unacceptable. The primary objective of the guide is to present information needed to evaluate the viability of cogeneration for new or existing industrial, commercial, and institutional (ICI) boiler installations and to make informed CHP equipment selection decisions. Information presented is meant to help boiler owners and operators understand the potential benefits derived from implementing a CHP project and recognize opportunities for successful application of cogeneration technology. Topics covered in the guide follow: (1) an overview of cogeneration technology with discussions about benefits of applying cogeneration technology and barriers to implementing cogeneration technology; (2) applicable federal regulations and permitting issues; (3) descriptions of prime movers commonly used in CHP applications, including discussions about design characteristics, heat-recovery options and equipment, fuels and emissions, efficiency, maintenance, availability, and capital cost; (4) electrical generators and electrical interconnection equipment; (5) cooling and dehumidification equipment; (6) thermodynamic cycle options and configurations; (7) steps for evaluating the technical and economic feasibility of applying cogeneration technology; and (8) information sources.« less

INCREASED SUSCEPTIBILITY OF THE SPONTANEOUSLY HYPERTENSIVE RAT TO CHLORPYRIFOS, AN ORGANOPHOSPHATE PESTICIDE.

EPA Science Inventory

Hypertension and hypothermia are common symptoms in rats exposed to chlorpyrifos (CHP), an organophosphate (OP)-based pesticide. CHP inhibits acetylcholinesterase (AChE) activity resulting in central and peripheral stimulation of cholinergic pathways involved in blood pressure ...

Report: EPA Should Improve Controls for Managing Contractor-Held Property

EPA Pesticide Factsheets

Report #12-P-0388, April 3, 2012. EPA does not have effective oversight of CHP, did not accurately report CHP in its FY 2010 financial statements, and did not fully implement corrective actions from an OIG 2006 audit report.

Relationship between DNA ploidy and proliferative cell nuclear antigen index in canine hemangiopericytoma.

PubMed

Kang, Seong-Kwi; Park, Nam-Yong; Cho, Ho-Sung; Shin, Sung-Shik; Kang, Mun-Il; Kim, Sang-Ki; Hyun, Changbaig; Park, In-Chul; Kim, Jong-Tack; Jeong, Cheol; Park, Sung-Hee; Park, Su-Jin; Jeong, Jae-Ho; Kim, You-Jung; Ochiai, Kenji; Umemura, Takashi; Cho, Kyoung-Oh

2006-03-01

The mitotic index is reported to be correlated with recurrence, mean patient survival, and metastasis of canine hemangiopericytoma (CHP). However, to the authors' knowledge, studies investigating the parameters that can predict recurrence or metastasis of CHP with low mitotic index have not been done. To evaluate growth kinetics of CHP with low mitotic index, a retrospective analysis of the proliferative activity by antiproliferative cell nuclear antigen monoclonal antibody and DNA contents by flow cytometry (FCM) was performed with 21 formalin-fixed and paraffin-embedded CHP samples. Of the 21 tumors evaluated by FCM, 6 (26.6%) were aneuploid tumors, and 15 (71.4%) were diploid tumors. There was significant correlation between the PCNA index and ploidy pattern. The diploid group had 39.1 +/- 9.2 PCNA index, whereas the aneuploid group's proliferative cell nuclear antigen (PCNA) index was 63.1 +/- 8.2. The diploid group had mean mitotic index value of 1.140 +/- 0.855, and the aneuploid group had a mean value of 1.067 +/- 0.767. From these results, the CHP samples with low mitotic index were classified into either the aneuploid group with higher PCNA index or the diploid group with lower PCNA index, suggesting that DNA ploidy and proliferative activity may give an indication about malignancy of CHPs with a low mitotic index.

Prescription pattern of chinese herbal products for breast cancer in taiwan: a population-based study.

PubMed

Lai, Jung-Nien; Wu, Chien-Tung; Wang, Jung-Der

2012-01-01

Background. Chinese herbal products (CHPs) given as a therapy for symptom relief have gained widespread popularity among women with breast cancer. The aim of this study was to analyze the utilization of CHP among women with breast cancer in Taiwan. Methods. The usage, frequency of services, and CHP prescribed for breast cancer among women with breast cancer were evaluated, recruited from a randomly sampled cohort of 1,000,000 beneficiaries from the National Health Insurance Research Database. The logistic regression method was employed to estimate the odds ratios (ORs) for utilization of CHP. Results. 81.5 percent (N = 2, 236) of women with breast cancer utilized traditional Chinese medicine (TCM) and 18% of them sought TCM with the intent of treating their breast cancer. Jia-wei-xiao-yao-san (Augmented Rambling Powder) was the most frequently prescribed formula for treating breast cancer. Among the top 10 most frequently prescribed CHP for treating breast cancer, seven contained dang qui (Angelica sinensis-radix) and six contained ren shen (Panax ginseng-radix), which are reported to have potential beneficial synergistic effects on breast cancer cells. Conclusion. CHP containing dang qui (Angelica sinensis-radix) or ren shen (Panax ginseng-radix) are the most frequently prescribed for breast cancer and their effects should be taken into account by healthcare providers.

Relationship between interphasic nucleolar organizer regions and growth rate in two neuroblastoma cell lines.

PubMed Central

Derenzini, M.; Pession, A.; Farabegoli, F.; Trerè, D.; Badiali, M.; Dehan, P.

1989-01-01

The relationship between the quantity of silver-stained interphasic nucleolar organizer regions (NORs) and nuclear synthetic activity, caryotype, and growth rate was studied in two established neuroblastoma cell lines (CHP 212 and HTB 10). Statistical analysis of silver-stained NORs revealed four times as many in CHP 212 cells compared with HTB 10 cells. No difference was observed in the ribosomal RNA synthesis between the two cell lines. The caryotype index was 1.2 for CHP 212 and 1.0 for HTB 10 cells. The number of chromosomes carrying NORs and the quantity of ribosomal genes was found to be the same for the two cell lines. Doubling time of CHP 212 cells was 20 hours compared with 54 hours for HTB 10 cells. In CHP 212 cells bindering of cell duplication by serum deprivation induced a progressive lowering (calculated at 48, 72, and 96 hours) of the quantity of silver-stained interphasic NORs. Recovery of duplication by new serum addition induced, after 24 hours, an increase of the quantity of silver-stained interphasic NORs up to control levels. In the light of available data, these results indicate that the quantity of interphasic NORs is strictly correlated only to the growth rate of the cell. Images Figure 2 Figure 3 Figure 4 PMID:2705511

Time-dependent transition of the immunoglobulin G subclass and immunoglobulin E response in cancer patients vaccinated with cholesteryl pullulan-melanoma antigen gene-A4 nanogel

PubMed Central

Kyogoku, Noriaki; Ikeda, Hiroaki; Tsuchikawa, Takahiro; Abiko, Takehiro; Fujiwara, Aki; Maki, Takehiro; Yamamura, Yoshiyuki; Ichinokawa, Masaomi; Tanaka, Kimitaka; Imai, Naoko; Miyahara, Yoshihiro; Kageyama, Shinichi; Shiku, Hiroshi; Hirano, Satoshi

2016-01-01

A phase I+II clinical trial of vaccination with MAGE-A4 protein complexed with cholesteryl pullulan melanoma antigen gene-A4 nanogel (CHP-MAGE-A4) is currently underway in patients with MAGE-A4-expressing cancer. In the present study, the primary phase I endpoint was to test the safety of the administration of 300 µg CHP-MAGE-A4 with and without OK-432. Another aim of the study was to clarify the details of the specific humoral immune response to vaccination. The 9 patients enrolled for phase I were vaccinated 6 times, once every 2 weeks: 3 patients with 100 µg and 3 patients with 300 µg CHP-MAGE-A4, and 3 patients with 300 µg CHP-MAGE-A4 plus 0.5 clinical units of OK-432. Toxicities were assessed using Common Terminology Criteria for Adverse Events v3.0. Clinical response was evaluated by modified Response Evaluation Criteria in Solid Tumours. Immunological monitoring of anti-MAGE-A4-specific antibodies was performed by ELISA of pre- and post-vaccination patient sera. The 6 vaccinations produced no severe adverse events. Stable disease was assessed in 4/9 patients. Anti-MAGE-A4 total immunoglobulin (Ig)G titers increased in 7/9 patients. Efficacious anti-MAGE-A4 IgG1, 2 and 3 antibody responses were observed in 7/9 patients. Among them, positive conversions to T helper 2 (Th2)-type antibody responses (IgG4 and IgE) were observed after frequent vaccination in 4/7 patients. The Th2 conversion was possibly associated with undesirable clinical observations, including progressive disease and the appearance of a new relapse lesion. The present study suggested that frequent vaccinations activated a Th2-dominant status in the cancer patients. The identification of a time-dependent IgG subclass and IgE antibody production during vaccination protocols may be a useful surrogate marker indicating a potentially undesirable change of the immunological environment for an effective antitumor immune response in cancer patients. PMID:28105158

Fuel and Carbon Dioxide Emissions Savings Calculation Methodology for Combined Heat and Power Systems

EPA Pesticide Factsheets

This paper provides the EPA Combined Heat and Power Partnership's recommended methodology for calculating fuel and carbon dioxide emissions savings from CHP compared to SHP, which serves as the basis for the EPA's CHP emissions calculator.

THE MUSCARINIC ANTAGONIST SCOPOLAMINE ATTENUATES CHLORPYRIFOS INDUCED HYPOTHERMIA IN THE DEVELOPING RAT.

EPA Science Inventory

Chlorpyrifos (CHP), an anticholinesterase organophosphate (OP) pesticide, induces acute hypothermia in adult and developing rats. Previously we demonstrated that thermoregulation in preweanling pups is markedly more sensitive to the neurotoxic effects of CHP than in adults. The c...

CHP and Local Governments: Case Studies and EPA’s New Guide (Webinar) – September 30, 2014

EPA Pesticide Factsheets

This webinar presents two case studies of CHP development projects undertaken through cooperation between private companies and government entities, and introduces an EPA guide to assist local governments to reduce greenhouse gas (GHG) emissions.

Opportunities for Combined Heat and Power at Wastewater Treatment Facilities: Market Analysis and Lessons from the Field

EPA Pesticide Factsheets

This report presents the opportunities for combined heat and power (CHP) applications in the municipal wastewater treatment sector, and it documents the experiences of the wastewater treatment facility (WWTF) operators who have employed CHP.

The Role of Distributed Generation and Combined Heat and Power (CHP) Systems in Data Centers

EPA Pesticide Factsheets

This report reviews how distributed generation (DG) resources such as fuel cells, reciprocating engines, and gas turbines can offer powerful energy efficiency savings in data centers, particularly when configured in combined heat and power (CHP) mode.

Self-selection of plant bioactive compounds by sheep in response to challenge infection with Haemonchus contortus.

PubMed

Poli, Cesar H E C; Thornton-Kurth, Kara J; Legako, Jerrad F; Bremm, Carolina; Hampel, Viviane S; Hall, Jeffery; Ipharraguerre, Ignacio R; Villalba, Juan J

2018-06-12

Plant bioactives can potentially benefit herbivores through their effects on health and nutrition. The objective of this study was to determine the importance of polyphenols and terpenes on the ability of lambs to self-select these compounds when challenged by a parasitic infection and the subsequent impact on their health and productivity. Thirty-five lambs were housed in individual pens and assigned to five treatment groups (7 animals/group), where they received: 1) A basal diet of beet pulp:soybean meal (90:10) (CONTROL); 2) The same diet, but containing 0.3% of bioactive natural plant compounds extracted from grape, olive and pomegranate (BNP); 3) A simultaneous offer of the diets offered to the Control and BNP groups (Choice-Parasitized; CHP-1); 4) The Control diet, and when lambs developed a parasitic infection, the choice described for CHP-1 (CHP-2); and 5) The same choice as CHP-1, but animals did not experience a parasitic burden (Choice-Non-Parasitized; CHNP). Lambs, except CHNP, were dosed with 10,000 L 3 stage larvae of Haemonchus contortus. Infected lambs under choice treatments (CHP-1 and CHP-2) modified their feeding behavior in relation to the CHNP group as they increased their preference for the feed containing polyphenols and terpenes, interpreted as a behavior aimed at increasing the likelihood of encountering medicinal compounds and nutrients in the environment that restore health. This change in behavior corresponded with an improvement in feed conversion efficiency. However, an increased preference for the diet with added plant bioactives did not have an effect on parasitic burdens, hematological parameters, blood oxidation, or serum concentration of IgE. Copyright © 2018. Published by Elsevier Inc.

5. 7 MW Tornados for Dunn Paper mill power CHP plant

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jeffs, E.

The first commercial installation in the United States of Ruston's high efficiency Tornado gas turbine is now fully operational at the Dunn Paper Company's Port Huron, Michigan paper mill where they make special light weight papers for packaging and business forms. It's a cogeneration installation powered by three Tornados and two waste heat recovery boilers which provide the mill with all of its electricity and process steam requirements - at high overall thermal efficiency.

Experimental investigation of domestic micro-CHP based on the gas boiler fitted with ORC module

NASA Astrophysics Data System (ADS)

Wajs, Jan; Mikielewicz, Dariusz; Bajor, Michał; Kneba, Zbigniew

2016-09-01

The results of investigations conducted on the prototype of vapour driven micro-CHP unit integrated with a gas boiler are presented. The system enables cogeneration of heat and electric energy to cover the energy demand of a household. The idea of such system is to produce electricity for own demand or for selling it to the electric grid - in such situation the system user will became the prosumer. A typical commercial gas boiler, additionally equipped with an organic Rankine cycle (ORC) module based on environmentally acceptable working fluid can be regarded as future generation unit. In the paper the prototype of innovative domestic cogenerative ORC system, consisting of a conventional gas boiler and a small size axial vapour microturbines (in-house designed for ORC and the commercially available for Rankine cycle (RC)), evaporator and condenser were scrutinised. In the course of study the fluid working temperatures, rates of heat, electricity generation and efficiency of the whole system were obtained. The tested system could produce electricity in the amount of 1 kWe. Some preliminary tests were started with water as working fluid and the results for that case are also presented. The investigations showed that domestic gas boiler was able to provide the saturated/superheated ethanol vapour (in the ORC system) and steam (in the RC system) as working fluids.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bloomquist, R.G.

District heating and cooling (DHC) can provide multiple opportunities to reduce air emissions associated with space conditioning and electricity generation, which contribute 30% to 50% of all such emissions. When DHC is combined with cogeneration (CHP), maximum reductions in sulfur oxides (SO{sub x}), nitrogen oxides (NO{sub x}), carbon dioxide (CO{sub 2}), particulates, and ozone-depleting chlorofluorocarbon (CFC) refrigerants can most effectively be achieved. Although significant improvements in air quality have been documented in Europe and Scandinavia due to DHC and CHP implementation, accurately predicting such improvements has been difficult. Without acceptable quantification methods, regulatory bodies are reluctant to grant air emissionsmore » credits, and local community leaders are unwilling to invest in DHC and CHP as preferred methods of providing energy or strategies for air quality improvement. The recent development and release of a number of computer models designed specifically to provide quantification of air emissions that can result from DHC and CHP implementation should help provide local, state, and national policymakers with information vital to increasing support and investment in DHC development.« less

Determination of organic peroxides by liquid chromatography with on-line post-column ultraviolet irradiation and peroxyoxalate chemiluminescence detection.

PubMed

Wada, Mitsuhiro; Inoue, Keiyu; Thara, Ayuko; Kishikawa, Naoya; Nakashima, Kenichiro; Kuroda, Naotaka

2003-02-14

A HPLC method was developed for the simultaneous determination of organic peroxides and hydrogen peroxide with peroxyoxalate chemiluminescence (PO-CL) detection following on-line UV irradiation. Organic peroxides [i.e., benzoyl peroxide (BP), tert.-butyl hydroperoxide (BHP), tert.-butyl perbenzoate (BPB), cumene hydroperoxide (CHP)] were UV irradiated (254 nm, 15 W) to generate hydrogen peroxide, which was determined by PO-CL detection. The conditions for UV irradiation and PO-CL detection were optimized by a flow injection analysis (FIA) system. Generation of hydrogen peroxide from peroxides with on-line UV irradiation also was confirmed by the FIA system by incorporating an enzyme column reactor immobilized with catalase. The separation of four organic peroxides and hydrogen peroxide by HPLC was accomplished isocratically on an ODS column within 30 min. The detection limits (signal-to-noise ratio=3) were 1.1 microM for hydrogen peroxide, 6.8 microM for BP, 31.3 microM for BHP, 7.5 microM for BPB and 1.3 microM for CHP. The proposed method was applied to the determination of BP in wheat flour.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mendes, Goncalo; Feng, Wei; Stadler, Michael

The following paper conducts a regional analysis of the U.S. and Chinese buildings? potential for adopting Distributed Energy Resources (DER). The expected economics of DER in 2020-2025 is modeled for a commercial and a multi-family residential building in different climate zones. The optimal building energy economic performance is calculated using the Distributed Energy Resources Customer Adoption Model (DER CAM) which minimizes building energy costs for a typical reference year of operation. Several DER such as combined heat and power (CHP) units, photovoltaics, and battery storage are considered. The results indicate DER have economic and environmental competitiveness potential, especially for commercialmore » buildings in hot and cold climates of both countries. In the U.S., the average expected energy cost savings in commercial buildings from DER CAM?s suggested investments is 17percent, while in Chinese buildings is 12percent. The electricity tariffs structure and prices along with the cost of natural gas, represent important factors in determining adoption of DER, more so than climate. High energy pricing spark spreads lead to increased economic attractiveness of DER. The average emissions reduction in commercial buildings is 19percent in the U.S. as a result of significant investments in PV, whereas in China, it is 20percent and driven by investments in CHP. Keywords: Building Modeling and Simulation, Distributed Energy Resources (DER), Energy Efficiency, Combined Heat and Power (CHP), CO2 emissions 1. Introduction The transition from a centralized and fossil-based energy paradigm towards the decentralization of energy supply and distribution has been a major subject of research over the past two decades. Various concerns have brought the traditional model into question; namely its environmental footprint, its structural inflexibility and inefficiency, and more recently, its inability to maintain acceptable reliability of supply. Under such a troubled setting, distributed energy resources (DER) comprising of small, modular, electrical renewable or fossil-based electricity generation units placed at or near the point of energy consumption, has gained much attention as a viable alternative or addition to the current energy system. In 2010, China consumed about 30percent of its primary energy in the buildings sector, leading the country to pay great attention to DER development and its applications in buildings. During the 11th Five Year Plan (FYP), China has implemented 371 renewable energy building demonstration projects, and 210 photovoltaics (PV) building integration projects. At the end of the 12th FYP, China is targeting renewable energy to provide 10percent of total building energy, and to save 30 metric tons of CO2 equivalents (mtce) of energy with building integrated renewables. China is also planning to implement one thousand natural gas-based distributed cogeneration demonstration projects with energy utilization rates over 70percent in the 12th FYP. All these policy targets require significant DER systems development for building applications. China?s fast urbanization makes building energy efficiency a crucial economic issue; however, only limited studies have been done that examine how to design and select suitable building energy technologies in its different regions. In the U.S., buildings consumed 40percent of the total primary energy in 2010 [1] and it is estimated that about 14 billion m2 of floor space of the existing building stock will be remodeled over the next 30 years. Most building?s renovation work has been on building envelope, lighting and HVAC systems. Although interest has emerged, less attention is being paid to DER for buildings. This context has created opportunities for research, development and progressive deployment of DER, due to its potential to combine the production of power and heat (CHP) near the point of consumption and delivering multiple benefits to customers, such as cost« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Darrow, Ken; Hedman, Bruce

Data centers represent a rapidly growing and very energy intensive activity in commercial, educational, and government facilities. In the last five years the growth of this sector was the electric power equivalent to seven new coal-fired power plants. Data centers consume 1.5% of the total power in the U.S. Growth over the next five to ten years is expected to require a similar increase in power generation. This energy consumption is concentrated in buildings that are 10-40 times more energy intensive than a typical office building. The sheer size of the market, the concentrated energy consumption per facility, and themore » tendency of facilities to cluster in 'high-tech' centers all contribute to a potential power infrastructure crisis for the industry. Meeting the energy needs of data centers is a moving target. Computing power is advancing rapidly, which reduces the energy requirements for data centers. A lot of work is going into improving the computing power of servers and other processing equipment. However, this increase in computing power is increasing the power densities of this equipment. While fewer pieces of equipment may be needed to meet a given data processing load, the energy density of a facility designed to house this higher efficiency equipment will be as high as or higher than it is today. In other words, while the data center of the future may have the IT power of ten data centers of today, it is also going to have higher power requirements and higher power densities. This report analyzes the opportunities for CHP technologies to assist primary power in making the data center more cost-effective and energy efficient. Broader application of CHP will lower the demand for electricity from central stations and reduce the pressure on electric transmission and distribution infrastructure. This report is organized into the following sections: (1) Data Center Market Segmentation--the description of the overall size of the market, the size and types of facilities involved, and the geographic distribution. (2) Data Center Energy Use Trends--a discussion of energy use and expected energy growth and the typical energy consumption and uses in data centers. (3) CHP Applicability--Potential configurations, CHP case studies, applicable equipment, heat recovery opportunities (cooling), cost and performance benchmarks, and power reliability benefits (4) CHP Drivers and Hurdles--evaluation of user benefits, social benefits, market structural issues and attitudes toward CHP, and regulatory hurdles. (5) CHP Paths to Market--Discussion of technical needs, education, strategic partnerships needed to promote CHP in the IT community.« less

Prescription Pattern of Chinese Herbal Products for Breast Cancer in Taiwan: A Population-Based Study

PubMed Central

Lai, Jung-Nien; Wu, Chien-Tung; Wang, Jung-Der

2012-01-01

Background. Chinese herbal products (CHPs) given as a therapy for symptom relief have gained widespread popularity among women with breast cancer. The aim of this study was to analyze the utilization of CHP among women with breast cancer in Taiwan. Methods. The usage, frequency of services, and CHP prescribed for breast cancer among women with breast cancer were evaluated, recruited from a randomly sampled cohort of 1,000,000 beneficiaries from the National Health Insurance Research Database. The logistic regression method was employed to estimate the odds ratios (ORs) for utilization of CHP. Results. 81.5 percent (N = 2, 236) of women with breast cancer utilized traditional Chinese medicine (TCM) and 18% of them sought TCM with the intent of treating their breast cancer. Jia-wei-xiao-yao-san (Augmented Rambling Powder) was the most frequently prescribed formula for treating breast cancer. Among the top 10 most frequently prescribed CHP for treating breast cancer, seven contained dang qui (Angelica sinensis-radix) and six contained ren shen (Panax ginseng-radix), which are reported to have potential beneficial synergistic effects on breast cancer cells. Conclusion. CHP containing dang qui (Angelica sinensis-radix) or ren shen (Panax ginseng-radix) are the most frequently prescribed for breast cancer and their effects should be taken into account by healthcare providers. PMID:22685488

Treatment of District Energy CHP Outputs in LEED® for Building Design and Construction: New Construction and Major Renovations

EPA Pesticide Factsheets

This fact sheet summarizes how buildings connected to a CHP- equipped district energy system can earn more LEED® points than they could otherwise earn. It presents guidance for meeting the LEED® Minimum Energy Performance prerequisite and calculating point

[Preparation and physicochemical property of carboxymethyl-chitosan/hyaluronic acid poly(vinyl alcohol) blend membrane].

PubMed

Liu, Wen; Li, Shuning; Chang, Jing; Han, Baoqin; Liu, Wanshun

2009-08-01

To prepare carboxymethyl-chitosan/hyaluronic acid/poly(vinyl alcohol) (CHP) blend membrane, evaluate its physicochemical properties and intraocular biocompatibility and to investigate its feasibility to be applied to glaucoma filtering surgery. CHP blend membrane was prepared using solution casting method after blending carboxymethyl-chitosan, HA and poly(vinyl alcohol) in a proportion of 5 : 4 : 1 (M/M). Its water absorption rate, swelling rate, permeability, and mechanical properties were detected. Subconjunctival fibroblasts separated from subconjunctival tissue of New Zealand white rabbits were cultured, and the cells at passage 4 were cultured on cell culture plate with or without the CHP blend membrane, serving as the experimental group and the control group, respectively. Effect of the CHP blend membrane on the subconjunctival fibroblasts was tested by MTT method 24, 48, and 72 hours after culture. Six New Zealand white rabbits were randomly divided into two groups (n = 3 rabbits per group), and the CHP blend membrane and SK gel were implanted into the rabbits' subconjunctival space and anterior chamber in the experimental group and the control group, respectively. Slit lamp observation and binocular reaction record were conducted 1, 3, 5, 9, 11, 20, 30, 45, and 60 days after operation. Corneal tissue harvested from the experimental group was observed using scanning electron microscope 15 days after operation to study ophthalmic biocompatibility and biodegradability. The water absorption rate and the swelling rate of the CHP blend membrane was 83.8% +/- 1.3% and 3.59 +/- 0.50, respectively. The tensile strength of the dry and the wet CHP blend membrane was (20.59 +/- 1.73) and (0.51 +/- 0.13) MPa, respectively. The breaking elongation rate of the dry and the wet CHP blend membrane was 10.69% +/- 1.16% and 53.15% +/- 2.46%, respectively. The CHP blend membrane had good permeability to NaCl and L-tyrosine. Absorbance (A) value of the experimental group 24, 48, and 72 hours after breeding was 0.207 +/- 0.083, 0.174 +/- 0.080, and 0.181 +/- 0.048, respectively, while the A value of the control group was 0.284 +/- 0.011, 0.272 +/- 0.083, and 0.307 +/- 0.056, respectively. Significant difference was evident between two groups (P < 0.05). In the experimental group, a small amount of floccus was exuded around the implanted membrane 1 day after operation; the floccus was absorbed on the third day, and there was no obvious inflammatory reaction occurring on the eleventh day. Most of the membrane degraded on the sixtieth day. Scanning electron microscope observation showed that the hexagonal morphology of the corneal endothelial cells was intact, and no degradation particles adhered to the surface. In the control group, the implantation of SK gel into anterior chamber was unsuccessful because the SK gel was quite soft and easily broken. In the experimental group, mild hyperemia emerged around the implanted membrane 1 day after the subconjunctival implantation of the membrane, and it became normal on the ninth day. No corneal edema and inflammatory reaction of anterior chamber occurred till the sixtieth day. The results in the control group and the experiment group were similar. Due to its good physicochemical properties and biocompatibility, the CHP blend membrane has potential applications in glaucoma filtering surgery.

The effect of antimicrobial photodynamic therapy on the expression of novel methicillin resistance markers determined using cDNA-AFLP approach in Staphylococcus aureus.

PubMed

Hoorijani, Mohammad Neshvan; Rostami, Hosein; Pourhajibagher, Maryam; Chiniforush, Nasim; Heidari, Mansour; Pourakbari, Babak; Kazemian, Hossein; Davari, Kambiz; Amini, Vahid; Raoofian, Reza; Bahador, Abbas

2017-09-01

Widespread methicillin resistant Staphylococcus aureus (MRSA) and absence of effective antimicrobial agents has led to limited therapeutic options for treating MRSA infection. We aimed to evaluate the effect of antimicrobial photodynamic therapy (aPDT) on the expression of novel identified methicillin resistance markers (NIMRMs) in S. aureus using complementary DNA-Amplified Fragment Length Polymorphism (cDNA-AFLP) approaches to address the therapeutic alternatives for MRSA infections. We used cDNA-AFLP to compare MRSA and methicillin susceptible S. aureus (MSSA) for identification of target genes implicated in methicillin resistance. To determine the sub-lethal aPDT (sPDT), MRSA and MSSA clinical isolates photosensitized with toluidine blue O (TBO), and then were irradiated with diode laser. After sPDT, the colony forming units/mL was quantified. Antimicrobial susceptibility against methicillin was assessed for cell-surviving aPDT. Effects of sPDT on the expression of NIMRMs were evaluated by real-time quantitative reverse transcription PCR. According to our results, serine hydrolase family protein (Shfp) encoding gene and a gene encoding a conserved hypothetical protein (Chp) were implicated in methicillin resistance in MRSA. sPDT reduced the minimum inhibitory concentrations of methicillin by 3-fold in MRSA. sPDT could lead to about 10- and 6.2- fold suppression of expression of the Chp and Shfp encoding genes, respectively. sPDT would lead to reduction in resistance to methicillin of MRSA in surviving cells by suppressing the expression of the Shfp and Chp encoding genes associated with methicillin resistance. This may have potential implications of aPDT for the treatment of MRSA infections. Copyright © 2017 Elsevier B.V. All rights reserved.

A price mechanism for supply demand matching in local grid of households with micro-CHP

NASA Astrophysics Data System (ADS)

Larsen, G. K. H.; van Foreest, N. D.; Scherpen, J. M. A.

2012-10-01

This paper describes a dynamic price mechanism to coordinate eletric power generation from micro Combined Heat and Power (micro-CHP) systems in a network of households. It is assumed that the households are prosumers, i.e. both producers and consumers of electricity. The control is done on household level in a completely distributed manner. Avoiding a centralized controller both eases computation complexity and preserves communication structure in the network. Local information is used to decide to turn on or off the micro-CHP, but through price signals between the prosumers the network as a whole operates in a cooperative way.

THERMOREGULATION IN THE RAT DURING CHRONIC, DIETARY EXPOSURE TO CHLORPYRIFOS, AN ORGANOPHOSPHATE INSECTICIDE.

EPA Science Inventory

Administration of chlorpyrifos (CHP) at a dose of 25 to 80 mg/kg (p.o.) To rats results in hypothermia followed by a fever lasting for several days. To understand if chronic, low level exposure to CHP affects thermoregulation in a comparable manner to acute administration, male L...

North Seattle Community College Chemical Hygiene Plan.

ERIC Educational Resources Information Center

North Seattle Community Coll., WA.

The goal of the Chemical Hygiene Plan (CHP), created by North Seattle Community College, is to provide an environment that protects and promotes health and safety and complies with health and safety laws. The CHP focuses especially on the laboratory workplace (biology and chemistry), as many hazardous materials can be found there. Employee…

A Compound Herbal Preparation (CHP) in the Treatment of Children with ADHD: A Randomized Controlled Trial

ERIC Educational Resources Information Center

Katz, M.; Adar Levine, A.; Kol-Degani, H.; Kav-Venaki, L.

2010-01-01

Objective: Evaluation of the efficacy of a patented, compound herbal preparation (CHP) in improving attention, cognition, and impulse control in children with ADHD. Method: Design: A randomized, double-blind, placebo-controlled trial. Setting: University-affiliated tertiary medical center. Participants: 120 children newly diagnosed with ADHD,…

Structural analysis and the effect of cyclo(His-Pro) dipeptide on neurotoxins--a dynamics and density functional theory study.

PubMed

Abiram, Angamuthu; Kolandaivel, Ponmalai

2010-02-01

The switching propensity and maximum probability of occurrence of the side chain imidazole group in the dipeptide cyclo(His-Pro) (CHP) were studied by applying molecular dynamics simulations and density functional theory. The atomistic behaviour of CHP with the neurotoxins glutamate (E) and paraquat (Pq) were also explored; E and Pq engage in hydrogen bond formation with the diketopiperazine (DKP) ring of the dipeptide, with which E shows a profound interaction, as confirmed further by NH and CO stretching vibrational frequencies. The effect of CHP was found to be greater on E than on Pq neurotoxin. A ring puckering study indicated a twist boat conformation for the six-membered DKP ring. Molecular electrostatic potential (MESP) mapping was also used to explore the hydrogen bond interactions prevailing between the neurotoxins and the DKP ring. The results of this study reveal that the DKP ring of the dipeptide CHP can be expected to play a significant role in reducing effects such as oxidative stress and cell death caused by neurotoxins.

Effectiveness of dishwashing liquids in removing chlorothalonil and chlorpyrifos residues from cherry tomatoes.

PubMed

Wang, Zhiwei; Huang, Jiexun; Chen, Jinyuan; Li, Feili

2013-08-01

Washing is the most practical way to remove pesticide residues in fruits and vegetables. Two commonly used kitchen dishwashing liquids (detergents) in Chinese market were tested for enhanced removal of chlorpyrifos (CHP) and chlorothalonil (CHT) in cherry tomatoes by soaking the cherry tomatoes in the detergent solutions. The critical micelle concentrations of detergent A and detergent B were about 250 mg L(-1) and 444 mg L(-1), respectively. Detergent A had a higher solubilizing ability for pesticides and hence washing effectiveness than detergent B. The apparent solubility of CHP increased with increasing detergent concentration, while that of CHT remained comparatively invariant independent of detergent concentration within the tested range. The apparent solubility of CHP was also consistently higher in solutions of both detergents as compared to CHT. Due probably to its lower logKow value, CHT was more readily washed off cherry tomatoes than CHP. In terms of washing, a duration of 10-20 min was sufficient for removal of pesticides on cherry tomatoes in distilled water and detergent solutions. The effectiveness of removing pesticides increased with increasing detergent concentration from 50 mg L(-1) to 5 g L(-1), with up to 80% CHT and 42% CHP removed. Multiple washing further increased pesticide removal. Adding 10% acetic acid to lower pH or increasing washing temperature favored pesticide removal, but 10% NaCl produced the shielding effect and substantially reduced the effectiveness of detergent A for pesticide removal. Copyright © 2013 Elsevier Ltd. All rights reserved.

Analysis of Competitiveness and Support Instruments for Heat and Electricity Production from Wood Biomass in Latvia

NASA Astrophysics Data System (ADS)

Klavs, G.; Kudrenickis, I.; Kundzina, A.

2012-01-01

Utilisation of renewable energy sources is one of the key factors in a search for efficient ways of reducing the emissions of greenhouse gases and improving the energy supply security. So far, the district heating supply in Latvia has been based on natural gas, with the wood fuel playing a minor role; the same is true for decentralised combined heat-power (CHP) production. The paper describes a method for evaluation of the economic feasibility of heat and electricity production from wood biomass under the competition between different fuel types and taking into account the electricity market. For the simulation, a cost estimation model is applied. The results demonstrate that wood biomass can successfully be utilised for competitive heat production by boiler houses, while for electricity production by CHP utilities it cannot compete on the market (even despite the low prices on wood biomass fuel) unless particular financial support instruments are applied. The authors evaluate the necessary support level and the impact of two main support instruments - the investment subsidies and the feed-in tariff - on the economic viability of wood-fuelled CHP plants, and show that the feed-in tariff could be considered as an instrument strongly affecting the competitiveness of such type CHP. Regarding the feed-in tariff determination, a compromise should be found between the economy-dictated requirement to develop CHP projects concerning capacities above 5 MWel - on the one hand, and the relatively small heat loads in many Latvian towns - on the other.

Molecular assessment of collagen denaturation in decellularized tissues using a collagen hybridizing peptide.

PubMed

Hwang, Jeongmin; San, Boi Hoa; Turner, Neill J; White, Lisa J; Faulk, Denver M; Badylak, Stephen F; Li, Yang; Yu, S Michael

2017-04-15

Decellularized extracellular matrix (ECM) derived from tissues and organs are emerging as important scaffold materials for regenerative medicine. Many believe that preservation of the native ECM structure during decellularization is highly desirable. However, because effective techniques to assess the structural damage in ECM are lacking, the disruptive effects of a decellularization method and the impact of the associated structural damage upon the scaffold's regenerative capacity are often debated. Using a novel collagen hybridizing peptide (CHP) that specifically binds to unfolded collagen chains, we investigated the molecular denaturation of collagen in the ECM decellularized by four commonly used cell-removing detergents: sodium dodecyl sulfate (SDS), 3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonate (CHAPS), sodium deoxycholate (SD), and Triton X-100. Staining of the detergent-treated porcine ligament and urinary bladder matrix with carboxyfluorescein-labeled CHP demonstrated that SDS and Triton X-100 denature the triple helical collagen molecule while CHAPS and SD do not, although second harmonic generation imaging and transmission electron microscopy (TEM) revealed that all four detergents disrupt collagen fibrils. Our findings from the CHP staining were further confirmed by the circular dichroism spectra of intact triple helical collagen molecules in CHAPS and SD solutions, and the TEM images of CHP-conjugated gold nanoparticles binding only to the SDS and Triton X-100 treated collagen fibrils. CHP is a powerful new tool for direct and reliable measurement of denatured collagen molecules in decellularized tissues. It is expected to have wide applications in the development and standardization of the tissue/organ decellularization technology. Preservation of the native ECM structure in decellularized tissues is highly desirable, since denaturation of ECM molecules (e.g., collagen) during decellularization can strongly influence the cellular response. Unfortunately, conventional techniques (SEM, SHG) are not conducive to identifying denatured collagen molecules in tissues. We demonstrate the first investigation into the molecular denaturation of collagen in decellularized ECM enabled by a novel Collagen Hybridizing Peptide (CHP) that specifically binds to unfolded collagen chains. We show that SDS and Triton X-100 denature collagen molecules while CHAPS and SD cannot. Such detection has been nearly impossible with other existing techniques. The CHP technique will advance our understanding about the effect of the cell-removing process on ECM, and lead to development of the decellularization technology. Copyright © 2017 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

Molecular assessment of collagen denaturation in decellularized tissues using a collagen hybridizing peptide

PubMed Central

Hwang, Jeongmin; San, Boi Hoa; Turner, Neill J.; White, Lisa J.; Faulk, Denver M.; Badylak, Stephen F.; Li, Yang; Yu, S. Michael

2017-01-01

Decellularized extracellular matrix (ECM) derived from tissues and organs are emerging as important scaffold materials for regenerative medicine. Many believe that preservation of the native ECM structure during decellularization is highly desirable. However, because effective techniques to assess the structural damage in ECM are lacking, the disruptive effects of a decellularization method and the impact of the associated structural damage upon the scaffold’s regenerative capacity are often debated. Using a novel collagen hybridizing peptide (CHP) that specifically binds to unfolded collagen chains, we investigated the molecular denaturation of collagen in the ECM decellularized by four commonly used cellremoving detergents: sodium dodecyl sulfate (SDS), 3-[(3-cholamidopropyl)dimethylammonio]-1-propa nesulfonate (CHAPS), sodium deoxycholate (SD), and Triton X-100. Staining of the detergent-treated porcine ligament and urinary bladder matrix with carboxyfluorescein-labeled CHP demonstrated that SDS and Triton X-100 denature the triple helical collagen molecule while CHAPS and SD do not, although second harmonic generation imaging and transmission electron microscopy (TEM) revealed that all four detergents disrupt collagen fibrils. Our findings from the CHP staining were further confirmed by the circular dichroism spectra of intact triple helical collagen molecules in CHAPS and SD solutions, and the TEM images of CHP-conjugated gold nanoparticles binding only to the SDS and Triton X-100 treated collagen fibrils. CHP is a powerful new tool for direct and reliable measurement of denatured collagen molecules in decellularized tissues. It is expected to have wide applications in the development and standardization of the tissue/organ decellularization technology. Statement of Significance Preservation of the native ECM structure in decellularized tissues is highly desirable, since denaturation of ECM molecules (e.g., collagen) during decellularization can strongly influence the cellular response. Unfortunately, conventional techniques (SEM, SHG) are not conducive to identifying denatured collagen molecules in tissues. We demonstrate the first investigation into the molecular denaturation of collagen in decellularized ECM enabled by a novel Collagen Hybridizing Peptide (CHP) that specifically binds to unfolded collagen chains. We show that SDS and Triton X-100 denature collagen molecules while CHAPS and SD cannot. Such detection has been nearly impossible with other existing techniques. The CHP technique will advance our understanding about the effect of the cell-removing process on ECM, and lead to development of the decellularization technology. PMID:28161576

Environmental implications of carbon limits on market penetration of combined heat and power with the U.S. energy sector (Slides)

EPA Science Inventory

Combined heat and power (CHP) is promoted as an economical, energy-efficient option for combating climate change. To fully examine the viability of CHP as a clean-technology solution, its market potential and impacts need to be analyzed as part of scenarios of the future energy s...

Bioenergy production from perennial energy crops: a consequential LCA of 12 bioenergy scenarios including land use changes.

PubMed

Tonini, Davide; Hamelin, Lorie; Wenzel, Henrik; Astrup, Thomas

2012-12-18

In the endeavor of optimizing the sustainability of bioenergy production in Denmark, this consequential life cycle assessment (LCA) evaluated the environmental impacts associated with the production of heat and electricity from one hectare of Danish arable land cultivated with three perennial crops: ryegrass (Lolium perenne), willow (Salix viminalis) and Miscanthus giganteus. For each, four conversion pathways were assessed against a fossil fuel reference: (I) anaerobic co-digestion with manure, (II) gasification, (III) combustion in small-to-medium scale biomass combined heat and power (CHP) plants and IV) co-firing in large scale coal-fired CHP plants. Soil carbon changes, direct and indirect land use changes as well as uncertainty analysis (sensitivity, MonteCarlo) were included in the LCA. Results showed that global warming was the bottleneck impact, where only two scenarios, namely willow and Miscanthus co-firing, allowed for an improvement as compared with the reference (-82 and -45 t CO₂-eq. ha⁻¹, respectively). The indirect land use changes impact was quantified as 310 ± 170 t CO₂-eq. ha⁻¹, representing a paramount average of 41% of the induced greenhouse gas emissions. The uncertainty analysis confirmed the results robustness and highlighted the indirect land use changes uncertainty as the only uncertainty that can significantly change the outcome of the LCA results.

Association of three putative periodontal pathogens with chronic periodontitis in Brazilian subjects

PubMed Central

GONÇALVES, Cristiane; SOARES, Geisla Mary S.; FAVERI, Marcelo; PÉREZ-CHAPARRO, Paula Juliana; LOBÃO, Eduardo; FIGUEIREDO, Luciene Cristina; BACCELLI, Gustavo Titonele; FERES, Magda

2016-01-01

ABSTRACT Objective The aim of this study was to evaluate the association of Porphyromonas endodontalis, Filifactor alocis and Dialister pneumosintes with the occurrence of periodontitis. Material and Methods Thirty subjects with chronic periodontitis (ChP) and 10 with periodontal health (PH) were included in the study. Nine subgingival biofilm samples were collected as follows: i) PH group - from the mesial/buccal aspect of each tooth in two randomly chosen contralateral quadrants; ii) ChP group - from three sites in each of the following probing depth (PD) categories: shallow (≤3 mm), moderate (4-6 mm) and deep (≥7 mm). Checkerboard DNA-DNA hybridization was used to analyze the samples. Results We found the three species evaluated in a higher percentage of sites and at higher levels in the group with ChP than in the PH group (p<0.05, Mann-Whitney test). We also observed these differences when the samples from sites with PD≤4 mm or ≥5 mm of subjects with ChP were compared with those from subjects with PH (p<0.05, Mann-Whitney test). In addition, the prevalence and levels of D. pneumosintes, and especially of F. alocis were very low in healthy subjects (0.12x105 and 0.01x105, respectively). Conclusion F. alocis and D. pneumosintes might be associated with the etiology of ChP, and their role in the onset and progression of this infection should be further investigated. The role of P. endodontalis was less evident, since this species was found in relatively high levels and prevalence in the PH group. PMID:27119767

Association of three putative periodontal pathogens with chronic periodontitis in Brazilian subjects.

PubMed

Gonçalves, Cristiane; Soares, Geisla Mary S; Faveri, Marcelo; Pérez-Chaparro, Paula Juliana; Lobão, Eduardo; Figueiredo, Luciene Cristina; Baccelli, Gustavo Titonele; Feres, Magda

2016-04-01

Objective The aim of this study was to evaluate the association of Porphyromonas endodontalis, Filifactor alocis and Dialister pneumosintes with the occurrence of periodontitis. Material and Methods Thirty subjects with chronic periodontitis (ChP) and 10 with periodontal health (PH) were included in the study. Nine subgingival biofilm samples were collected as follows: i) PH group - from the mesial/buccal aspect of each tooth in two randomly chosen contralateral quadrants; ii) ChP group - from three sites in each of the following probing depth (PD) categories: shallow (≤3 mm), moderate (4-6 mm) and deep (≥7 mm). Checkerboard DNA-DNA hybridization was used to analyze the samples. Results We found the three species evaluated in a higher percentage of sites and at higher levels in the group with ChP than in the PH group (p<0.05, Mann-Whitney test). We also observed these differences when the samples from sites with PD≤4 mm or ≥5 mm of subjects with ChP were compared with those from subjects with PH (p<0.05, Mann-Whitney test). In addition, the prevalence and levels of D. pneumosintes, and especially of F. alocis were very low in healthy subjects (0.12x105 and 0.01x105, respectively). Conclusion F. alocis and D. pneumosintes might be associated with the etiology of ChP, and their role in the onset and progression of this infection should be further investigated. The role of P. endodontalis was less evident, since this species was found in relatively high levels and prevalence in the PH group.

Effects of cyclic hydraulic pressure on osteocytes.

PubMed

Liu, Chao; Zhao, Yan; Cheung, Wing-Yee; Gandhi, Ronak; Wang, Liyun; You, Lidan

2010-05-01

Bone is able to adapt its composition and structure in order to suit its mechanical environment. Osteocytes, bone cells embedded in the calcified matrix, are believed to be the mechanosensors and responsible for orchestrating the bone remodeling process. Recent in vitro studies have shown that osteocytes are able to sense and respond to substrate strain and fluid shear. However the capacity of osteocytes to sense cyclic hydraulic pressure (CHP) associated with physiological mechanical loading is not well understood. In this study, we subjected osteocyte-like MLO-Y4 cells to controlled CHP of 68 kPa at 0.5 Hz, and investigated the effects of CHP on intracellular calcium concentration, cytoskeleton organization, mRNA expression of genes related to bone remodeling, and osteocyte apoptosis. We found that osteocytes were able to sense CHP and respond by increased intracellular calcium concentration, altered microtubule organization, a time-dependent increase in COX-2 mRNA level and RANKL/OPG mRNA ratio, and decreased apoptosis. These findings support the hypothesis that loading induced cyclic hydraulic pressure in bone serves as a mechanical stimulus to osteocytes and may play a role in regulating bone remodeling in vivo. Copyright (c) 2010 Elsevier Inc. All rights reserved.

Cytophagic histiocytic panniculitis and hemophagocytic lymphohistiocytosis: an overview.

PubMed

Aronson, Iris K; Worobec, Sophie M

2010-01-01

Cytophagic histiocytic panniculitis (CHP) is a rare panniculitis that is associated with systemic features including fevers, hepatosplenomegaly, lymphadenopathy, pancytopenia, hepatic abnormalities, hypertriglyceridemia, and coagulopathy without an elevated erythrocyte sedimentation rate. The panniculitis lesions show adipose tissue lymphocytic and histiocytic infiltration along with hemophagocytosis, which may also appear in bone marrow, spleen, lymph nodes, and liver. Patients may have a rapidly fatal disease course, a longer disease course with intermittent remissions and exacerbations for many years prior to death, or a nonfatal acute or intermittent course responsive to treatment. The cytophagocytic disorder in these patients is a hemophagocytic lymphohistiocytosis (HLH), similar to the infection-activated reaction associated with perforin mutations found in familial hemophagocytic lymphohistiocytosis. HLH is a group of autoinflammatory disorders, which include macrophage activation syndrome and infection-associated hemophagocytic syndrome, which if not treated rapidly, can be fatal. The relationship of CHP and HLH is discussed. CHP associated diseases include: subcutaneous panniculitis-like T cell lymphomas; infections, connective tissue diseases, other malignancies, and the molecular disorders that cause HLH. Treatment of CHP includes: glucocorticoids in combination with cyclosporine, combined chemotherapeutic medications and most recently, anakinra, an Interleukin-1 receptor antagonist; along with supportive care, search for underlying malignancies and treatment thereof, and control of associated infections.

IDEA Clean Energy Application Center

DOE Office of Scientific and Technical Information (OSTI.GOV)

Thornton, Robert P.

The DOE Clean Energy Application Centers were launched with a goal of focusing on important aspects of our nation’s energy supply including Efficiency, Reliability and Resiliency. Clean Energy solutions based on Combined Heat & Power (CHP), District Energy and Waste Heat Recovery are at the core of ensuring a reliable and efficient energy infrastructure for campuses, communities, and industry and public enterprises across the country. IDEA members which include colleges and universities, hospitals, airports, downtown utilities as well as manufacturers, suppliers and service providers have long-standing expertise in the planning, design, construction and operations of Clean Energy systems. They representmore » an established base of successful projects and systems at scale and serve important and critical energy loads. They also offer experience, lessons learned and best practices which are of immense value to the sustained growth of the Clean Energy sector. IDEA has been able to leverage the funds from the project award to raise the visibility, improve the understanding and increase deployment CHP, District Energy and Waste Heat Recovery solutions across the regions of our nation, in collaboration with the regional CEAC’s. On August 30, 2012, President Obama signed an Executive Order to accelerate investments in industrial energy efficiency (EE), including CHP and set a national goal of 40 GW of new CHP installation over the next decade IDEA is pleased to have been able to support this Executive Order in a variety of ways including raising awareness of the goal through educational workshops and Conferences and recognizing the installation of large scale CHP and district energy systems. A supporting key area of collaboration has involved IDEA providing technical assistance on District Energy/CHP project screenings and feasibility to the CEAC’s for multi building, multi-use projects. The award was instrumental in the development of a first-order screening/feasibility tool for these types of community energy projects. The Excel based tool incorporates hourly climate based building loads data to arrive at the composite energy demand for the district and compares the Net Present Value (NPV) of the costs of CHP/DE alternatives. This tool has been used to provide assistance to several projects in the Northeast, Mid-Atlantic, Intermountain and Pacific Regions. The tool was disseminated to the CEACs and supplemented by a Training Webinar and a How to Guide IDEA produced a US Community Energy Development Guide to support mayors, planners, community leaders, real estate developers and economic development officials who are interested in planning more sustainable urban energy infrastructure, creating community energy master plans and implementing CHP/ District Energy systems in cities, communities and towns. IDEA has collected industry data and provided a comprehensive data set containing information on District Energy installations in the US. District energy systems are present in 49 states and theDistrict of Columbia. Of the 597 systems 55% were DE alone while the remainder was some combination of CHP, district heating, and district cooling. District energy systems that do not currently involve electric generation are strong near-term candidates for the adoption of CHP due to the magnitude of their aggregated thermal load. This data has helped inform specific and targeted initiatives including technical assistance provided by the CEAC’s for EPA’s Boiler MACT Compliance by large District Heating System boilers. These outcomes have been greatly enabled by the close coordination and collaboration with DOE CEAC leadership and with the eight regional US DOE Clean Energy Application Centers and the award’s incremental funding has allowed IDEA to leverage our resources to be an effective champion for Clean Energy.« less

Global Transcriptional Response to Organic Hydroperoxide and the Role of OhrR in the Control of Virulence Traits in Chromobacterium violaceum.

PubMed

Previato-Mello, Maristela; Meireles, Diogo de Abreu; Netto, Luis Eduardo Soares; da Silva Neto, José Freire

2017-08-01

A major pathway for the detoxification of organic hydroperoxides, such as cumene hydroperoxide (CHP), involves the MarR family transcriptional regulator OhrR and the peroxidase OhrA. However, the effect of these peroxides on the global transcriptome and the contribution of the OhrA/OhrR system to bacterial virulence remain poorly explored. Here, we analyzed the transcriptome profiles of Chromobacterium violaceum exposed to CHP and after the deletion of ohrR , and we show that OhrR controls the virulence of this human opportunistic pathogen. DNA microarray and Northern blot analyses of CHP-treated cells revealed the upregulation of genes related to the detoxification of peroxides (antioxidant enzymes and thiol-reducing systems), the degradation of the aromatic moiety of CHP (oxygenases), and protection against other secondary stresses (DNA repair, heat shock, iron limitation, and nitrogen starvation responses). Furthermore, we identified two upregulated genes ( ohrA and a putative diguanylate cyclase with a GGDEF domain for cyclic di-GMP [c-di-GMP] synthesis) and three downregulated genes (hemolysin, chitinase, and collagenase) in the ohrR mutant by transcriptome analysis. Importantly, we show that OhrR directly repressed the expression of the putative diguanylate cyclase. Using a mouse infection model, we demonstrate that the ohrR mutant was attenuated for virulence and showed a decreased bacterial burden in the liver. Moreover, an ohrR -diguanylate cyclase double mutant displayed the same virulence as the wild-type strain. In conclusion, we have defined the transcriptional response to CHP, identified potential virulence factors such as diguanylate cyclase as members of the OhrR regulon, and shown that C. violaceum uses the transcriptional regulator OhrR to modulate its virulence. Copyright © 2017 American Society for Microbiology.

Global Transcriptional Response to Organic Hydroperoxide and the Role of OhrR in the Control of Virulence Traits in Chromobacterium violaceum

PubMed Central

Previato-Mello, Maristela; Meireles, Diogo de Abreu; Netto, Luis Eduardo Soares

2017-01-01

ABSTRACT A major pathway for the detoxification of organic hydroperoxides, such as cumene hydroperoxide (CHP), involves the MarR family transcriptional regulator OhrR and the peroxidase OhrA. However, the effect of these peroxides on the global transcriptome and the contribution of the OhrA/OhrR system to bacterial virulence remain poorly explored. Here, we analyzed the transcriptome profiles of Chromobacterium violaceum exposed to CHP and after the deletion of ohrR, and we show that OhrR controls the virulence of this human opportunistic pathogen. DNA microarray and Northern blot analyses of CHP-treated cells revealed the upregulation of genes related to the detoxification of peroxides (antioxidant enzymes and thiol-reducing systems), the degradation of the aromatic moiety of CHP (oxygenases), and protection against other secondary stresses (DNA repair, heat shock, iron limitation, and nitrogen starvation responses). Furthermore, we identified two upregulated genes (ohrA and a putative diguanylate cyclase with a GGDEF domain for cyclic di-GMP [c-di-GMP] synthesis) and three downregulated genes (hemolysin, chitinase, and collagenase) in the ohrR mutant by transcriptome analysis. Importantly, we show that OhrR directly repressed the expression of the putative diguanylate cyclase. Using a mouse infection model, we demonstrate that the ohrR mutant was attenuated for virulence and showed a decreased bacterial burden in the liver. Moreover, an ohrR-diguanylate cyclase double mutant displayed the same virulence as the wild-type strain. In conclusion, we have defined the transcriptional response to CHP, identified potential virulence factors such as diguanylate cyclase as members of the OhrR regulon, and shown that C. violaceum uses the transcriptional regulator OhrR to modulate its virulence. PMID:28507067

Comparison of Simulated Microgravity and Hydrostatic Pressure for Chondrogenesis of hASC.

PubMed

Mellor, Liliana F; Steward, Andrew J; Nordberg, Rachel C; Taylor, Michael A; Loboa, Elizabeth G

2017-04-01

Cartilage tissue engineering is a growing field due to the lack of regenerative capacity of native tissue. The use of bioreactors for cartilage tissue engineering is common, but the results are controversial. Some studies suggest that microgravity bioreactors are ideal for chondrogenesis, while others show that mimicking hydrostatic pressure is crucial for cartilage formation. A parallel study comparing the effects of loading and unloading on chondrogenesis has not been performed. The goal of this study was to evaluate chondrogenesis of human adipose-derived stem cells (hASC) under two different mechanical stimuli relative to static culture: microgravity and cyclic hydrostatic pressure (CHP). Pellets of hASC were cultured for 14 d under simulated microgravity using a rotating wall vessel bioreactor or under CHP (7.5 MPa, 1 Hz, 4 h · d-1) using a hydrostatic pressure vessel. We found that CHP increased mRNA expression of Aggrecan, Sox9, and Collagen II, caused a threefold increase in sulfated glycosaminoglycan production, and resulted in stronger vimentin staining intensity and organization relative to microgravity. In addition, Wnt-signaling patterns were altered in a manner that suggests that simulated microgravity decreases chondrogenic differentiation when compared to CHP. Our goal was to compare chondrogenic differentiation of hASC using a microgravity bioreactor and a hydrostatic pressure vessel, two commonly used bioreactors in cartilage tissue engineering. Our results indicate that CHP promotes hASC chondrogenesis and that microgravity may inhibit hASC chondrogenesis. Our findings further suggest that cartilage formation and regeneration might be compromised in space due to the lack of mechanical loading.Mellor LF, Steward AJ, Nordberg RC, Taylor MA, Loboa EG. Comparison of simulated microgravity and hydrostatic pressure for chondrogenesis of hASC. Aerosp Med Hum Perform. 2017; 88(4):377-384.

The prescribing of Chinese herbal products in Taiwan: a cross-sectional analysis of the national health insurance reimbursement database.

PubMed

Hsieh, Shu-Ching; Lai, Jung-Nien; Lee, Chuan-Fang; Hu, Fu-Chang; Tseng, Wei-Lum; Wang, Jung-Der

2008-06-01

The consumption of Chinese herbal products (CHPs) is increasing exponentially. However, the scientific evidence is lacking and there is an urgent requirement for detailed pharmacoepidemiological information on CHP usage. This study was to investigate CHP prescription patterns in Taiwan. We carried out a cross-sectional analysis on a cohort of 200,000 patients based on 2004 data from the National Health Insurance (NHI) reimbursement database. Data mining techniques were applied to explore CHP co-prescription patterns. A total of 46,938 patients had been prescribed CHPs on at least one occasion in 2004. Patients using CHPs were generally female and middle-aged, made more outpatient visits, had fewer hospitalizations and consumed more medical resources than non-users of CHPs. A total of 1,073,030 CHPs were contained within 220,123 prescriptions, for which acute nasopharyngitis was the most common indication. Yan hu suo and Jia Wei Xiao Yao San were the most frequently prescribed single herb (SH) and herbal formula (HF), respectively. The results of the data mining showed that the best predictions were provided by co-prescriptions of 'Mo yao and Ru xiang', 'Ye jiao teng and Suan Zao Ren Tan' and 'Dang Gui Nian Tong Tang and Shu Jing Huo Xue Tang' in the groups of SH-SH, SH-HF and HF-HF, respectively. This study provides national-level CHP prescription profiles and utilization rates, and documents, for the first time, HF-HF prescription combinations in Chinese medicine (CM) practices in Taiwan. We conclude that more studies are needed to validate the safety and effectiveness of CHP prescriptions.

Environmental & economic life cycle assessment of current & future sewage sludge to energy technologies.

PubMed

Mills, N; Pearce, P; Farrow, J; Thorpe, R B; Kirkby, N F

2014-01-01

The UK Water Industry currently generates approximately 800GWh pa of electrical energy from sewage sludge. Traditionally energy recovery from sewage sludge features Anaerobic Digestion (AD) with biogas utilisation in combined heat and power (CHP) systems. However, the industry is evolving and a number of developments that extract more energy from sludge are either being implemented or are nearing full scale demonstration. This study compared five technology configurations: 1 - conventional AD with CHP, 2 - Thermal Hydrolysis Process (THP) AD with CHP, 3 - THP AD with bio-methane grid injection, 4 - THP AD with CHP followed by drying of digested sludge for solid fuel production, 5 - THP AD followed by drying, pyrolysis of the digested sludge and use of the both the biogas and the pyrolysis gas in a CHP. The economic and environmental Life Cycle Assessment (LCA) found that both the post AD drying options performed well but the option used to create a solid fuel to displace coal (configuration 4) was the most sustainable solution economically and environmentally, closely followed by the pyrolysis configuration (5). Application of THP improves the financial and environmental performance compared with conventional AD. Producing bio-methane for grid injection (configuration 3) is attractive financially but has the worst environmental impact of all the scenarios, suggesting that the current UK financial incentive policy for bio-methane is not driving best environmental practice. It is clear that new and improving processes and technologies are enabling significant opportunities for further energy recovery from sludge; LCA provides tools for determining the best overall options for particular situations and allows innovation resources and investment to be focused accordingly. Copyright © 2013 The Authors. Published by Elsevier Ltd.. All rights reserved.

When do parents and child health professionals agree on child's psychosocial problems? Cross-sectional study on parent-child health professional dyads.

PubMed

Crone, Mathilde R; Zeijl, Elke; Reijneveld, Sijmen A

2016-05-19

About one third of all parents have concerns about their child's psychosocial development. Agreement between child health professionals (CHPs) and parents about such concerns may improve treatment adherence and outcomes. This study investigates which child, parenting and/or environmental stressors are associated with (dis)agreement in concerns regarding psychosocial problems in children, in parent-CHP dyads. During routine child health assessments, data were collected from a sample of children aged 14 months to 12 years (n = 3,870). CHPs registered the psychosocial problems that they identified, and parents reported their concerns. Child psychosocial stressors were measured with the ITSEA/CBCL, and the child's history of psychosocial problems. Environmental stressors referred to stressful family/contextual situations in the past year, and parenting stressors to perceived parenting efficacy. The CHPs and parents disagreed on 36.4 % of the children. CHPs based their identification of problems mainly on children's history of past problem (OR = 5.85, 95% CI = 4.74-7.22). Parental concerns were most likely in case of an increased ITSEA/CBCL score (OR = 7.69, CI = 5.39-10.97). CHP-parent agreement was more likely in case of a combination of child psychosocial, parenting and environmental stressors (OR = 35.58, CI = 24.11-52.48). Parental concerns not confirmed by the CHP were associated with higher educated parents, originating from an industrialized country, and younger children. The CHP-identified problems not confirmed by parental concerns were associated with older children. Agreement between CHPs and parents is associated with a co-occurrence of child, parenting and environmental stressors. Improved agreement between CHP and parents will increase the likelihood of shared decision-making regarding follow-up care and compliance with advice.

Lipid parameters in obese and normal weight patients with or without chronic periodontitis.

PubMed

Cury, Eduardo Zaccarias; Santos, Vanessa Renata; Maciel, Suellen da Silva; Gonçalves, Tiago Eduardo Dias; Zimmermann, Glaucia Santos; Mota, Rosa Maria Salani; Figueiredo, Luciene Cristina; Duarte, Poliana Mendes

2018-01-01

The aim of this study was to evaluate the serum levels of lipids in patients with normal weight (NW) or obesity with or without chronic periodontitis (ChP). One hundred and sixty non-smoking patients without history of diabetes and/or cardiovascular events were allocated into one of the following groups: NW patients with periodontal health (NWH; n = 40), NW patients with ChP (NWChP; n = 40), obese patients with periodontal health (ObH; n = 40), and obese patients with ChP (ObChP; n = 40). Serum levels of total cholesterol (TC), low-density lipoprotein (LDL), high-density lipoprotein (HDL), and triglycerides (TRG) were estimated. After adjustments for gender and age, both NW groups presented lower levels of TRG than both obese groups (p < 0.05). The NWH group presented lower levels of LDL than both periodontitis groups (p < 0.05) and the lowest TC/HDL ratio when compared to the other groups (p < 0.05). Females from the NWH group exhibited higher levels of HDL and lower LDL/HDL ratio than females from the ObChP group (p < 0.05). Furthermore, individuals from the ObChP group were more likely to have levels of LDL ≥130 mg/dl and HDL ≤40 mg/dl, compared to those from the NWH group (p < 0.05). ChP and obesity, jointly or individually, are associated with undesirable pro-atherogenic lipid profiles. There is interest in identifying clinical conditions associated with dyslipidemia to improve preventive and treatment strategies. This study demonstrated that ChP, obesity, and the association of both conditions might be related to pro-atherogenic lipid profiles.

Effectiveness of the Challenging Horizons After-School Program for Young Adolescents With ADHD

PubMed Central

Evans, Steven W.; Schultz, Brandon K.; DeMars, Christine E.; Davis, Heather

2012-01-01

There are no empirically supported psychosocial treatments for adolescents with attention-deficit hyperactivity disorder (ADHD). This study examined the treatment benefits of the Challenging Horizons Program (CHP), a psychosocial treatment program designed to address the impairment and symptoms associated with this disorder in young adolescents. In addition to evaluating social and academic functioning outcomes, two critical questions from previous studies pertaining to the timing, duration, and family involvement in treatment were addressed. Forty-nine students recruited in two cohorts were randomly assigned to receive either the CHP or a community care condition. Outcomes suggested that students who received the CHP improved compared to students in the control condition on measures of symptoms and impairment. Implications related to timing, duration, and family involvement are reported, as well as recommendations for future studies. PMID:21658528

Electricity Market Liberalisation and Flexibility of Conventional Generation to Balance Intermittent Renewable Energy - Is It Possible to Stay Competitive?

NASA Astrophysics Data System (ADS)

Linkevics, O.; Ivanova, P.; Balodis, M.

2016-12-01

Intermittent generation (solar PV and wind energy) integration in power production portfolio as well as electricity price fluctuations have changed the running manner of conventional combined heat and power (CHP) plants: the shift from base load operation to running in cyclic modes. These cogeneration power plants are not adapted to new running conditions. The level of CHP plant flexibility should be improved to operate profitably and efficiently from both technical and fuel usage point of view. There are different ways to increase the flexibility of power plants. Before any improvements, the situation at power plants should be evaluated and the weakest points defined. In this publication, such measures are presented on Riga CHP-2 plant example: installation of heat storage tank; extension of operation rang; acceleration of start-ups.

Final Technical Report: Affordable, High-Performance, Intermediate Temperature Solid Oxide Fuel Cells

DOE Office of Scientific and Technical Information (OSTI.GOV)

Blackburn, Bryan M.; Bishop, Sean; Gore, Colin

In this project, we improved the power output and voltage efficiency of our intermediate temperature solid oxide fuel cells (IT-SOFCs) with a focus on ~600 °C operation. At these temperatures and with the increased power density (i.e., fewer cells for same power output), the stack cost should be greatly reduced while extending durability. Most SOFC stacks operate at temperatures greater than 800 °C. This can greatly increase the cost of the system (stacks and BOP) as well as maintenance costs since the most common degradation mechanisms are thermally driven. Our approach uses no platinum group metal (PGM) materials and themore » lower operating temperature allows use of simple stainless steel interconnects and commercial off-the-shelf gaskets in the stack. Furthermore, for combined heating and power (CHP) applications the stack exhaust still provides “high quality” waste heat that can be recovered and used in a chiller or boiler. The anticipated performance, durability, and resulting cost improvements (< $700/kWe) will also move us closer to reaching the full potential of this technology for distributed generation (DG) and residential/commercial CHP. This includes eventual extension to cleaner, more efficient portable generators, auxiliary power units (APUs), and range extenders for transportation. The research added to the understanding of the area investigated by exploring various methods for increasing power density (Watts/square centimeter of active area in each cell) and increasing cell efficiency (increasing the open circuit voltage, or cell voltage with zero external electrical current). The results from this work demonstrated an optimized cell that had greater than 1 W/cm2 at 600 °C and greater than 1.6 W/cm2 at 650 °C. This was demonstrated in large format sizes using both 5 cm by 5 cm and 10 cm by 10 cm cells. Furthermore, this work demonstrated that high stability (no degradation over > 500 hours) can be achieved together with high performance in large format cells as large as 10 cm by 10 cm when operated at ~600 °C. The project culminated in the demonstration of a 12-cell stack using the porous anode-based SOFC technology.« less

Cost related sensitivity analysis for optimal operation of a grid-parallel PEM fuel cell power plant

NASA Astrophysics Data System (ADS)

El-Sharkh, M. Y.; Tanrioven, M.; Rahman, A.; Alam, M. S.

Fuel cell power plants (FCPP) as a combined source of heat, power and hydrogen (CHP&H) can be considered as a potential option to supply both thermal and electrical loads. Hydrogen produced from the FCPP can be stored for future use of the FCPP or can be sold for profit. In such a system, tariff rates for purchasing or selling electricity, the fuel cost for the FCPP/thermal load, and hydrogen selling price are the main factors that affect the operational strategy. This paper presents a hybrid evolutionary programming and Hill-Climbing based approach to evaluate the impact of change of the above mentioned cost parameters on the optimal operational strategy of the FCPP. The optimal operational strategy of the FCPP for different tariffs is achieved through the estimation of the following: hourly generated power, the amount of thermal power recovered, power trade with the local grid, and the quantity of hydrogen that can be produced. Results show the importance of optimizing system cost parameters in order to minimize overall operating cost.

Space Heating Load Estimation Procedure for CHP Systems sizing

NASA Astrophysics Data System (ADS)

Vocale, P.; Pagliarini, G.; Rainieri, S.

2015-11-01

Due to its environmental and energy benefits, the Combined Heat and Power (CHP) represents certainly an important measure to improve energy efficiency of buildings. Since the energy performance of the CHP systems strongly depends on the fraction of the useful cogenerated heat (i.e. the cogenerated heat that is actually used to meet building thermal demand), in building applications of CHP, it is necessary to know the space heating and cooling loads profile to optimise the system efficiency. When the heating load profile is unknown or difficult to calculate with a sufficient accuracy, as may occur for existing buildings, it can be estimated from the cumulated energy uses by adopting the loads estimation procedure (h-LEP). With the aim to evaluate the useful fraction of the cogenerated heat for different operating conditions in terms of buildings characteristics, weather data and system capacity, the h-LEP is here implemented with a single climate variable: the hourly average dry- bulb temperature. The proposed procedure have been validated resorting to the TRNSYS simulation tool. The results, obtained by considering a building for hospital use, reveal that the useful fraction of the cogenerated heat can be estimated with an average accuracy of ± 3%, within the range of operative conditions considered in the present study.

Market Assessment of Biomass Gasification and Combustion Technology for Small- and Medium-Scale Applications

DOE Office of Scientific and Technical Information (OSTI.GOV)

Peterson, D.; Haase, S.

2009-07-01

This report provides a market assessment of gasification and direct combustion technologies that use wood and agricultural resources to generate heat, power, or combined heat and power (CHP) for small- to medium-scale applications. It contains a brief overview of wood and agricultural resources in the U.S.; a description and discussion of gasification and combustion conversion technologies that utilize solid biomass to generate heat, power, and CHP; an assessment of the commercial status of gasification and combustion technologies; a summary of gasification and combustion system economics; a discussion of the market potential for small- to medium-scale gasification and combustion systems; andmore » an inventory of direct combustion system suppliers and gasification technology companies. The report indicates that while direct combustion and close-coupled gasification boiler systems used to generate heat, power, or CHP are commercially available from a number of manufacturers, two-stage gasification systems are largely in development, with a number of technologies currently in demonstration. The report also cites the need for a searchable, comprehensive database of operating combustion and gasification systems that generate heat, power, or CHP built in the U.S., as well as a national assessment of the market potential for the systems.« less

Elucidation and chemical modulation of sulfolipid-1 biosynthesis in Mycobacterium tuberculosis.

PubMed

Seeliger, Jessica C; Holsclaw, Cynthia M; Schelle, Michael W; Botyanszki, Zsofia; Gilmore, Sarah A; Tully, Sarah E; Niederweis, Michael; Cravatt, Benjamin F; Leary, Julie A; Bertozzi, Carolyn R

2012-03-09

Mycobacterium tuberculosis possesses unique cell-surface lipids that have been implicated in virulence. One of the most abundant is sulfolipid-1 (SL-1), a tetraacyl-sulfotrehalose glycolipid. Although the early steps in SL-1 biosynthesis are known, the machinery underlying the final acylation reactions is not understood. We provide genetic and biochemical evidence for the activities of two proteins, Chp1 and Sap (corresponding to gene loci rv3822 and rv3821), that complete this pathway. The membrane-associated acyltransferase Chp1 accepts a synthetic diacyl sulfolipid and transfers an acyl group regioselectively from one donor substrate molecule to a second acceptor molecule in two successive reactions to yield a tetraacylated product. Chp1 is fully active in vitro, but in M. tuberculosis, its function is potentiated by the previously identified sulfolipid transporter MmpL8. We also show that the integral membrane protein Sap and MmpL8 are both essential for sulfolipid transport. Finally, the lipase inhibitor tetrahydrolipstatin disrupts Chp1 activity in M. tuberculosis, suggesting an avenue for perturbing SL-1 biosynthesis in vivo. These data complete the SL-1 biosynthetic pathway and corroborate a model in which lipid biosynthesis and transmembrane transport are coupled at the membrane-cytosol interface through the activity of multiple proteins, possibly as a macromolecular complex.

Support schemes and ownership structures - the policy context for fuel cell based micro-combined heat and power

NASA Astrophysics Data System (ADS)

Schroeder, Sascha Thorsten; Costa, Ana; Obé, Elisabeth

In recent years, fuel cell based micro-combined heat and power (mCHP) has received increasing attention due to its potential contribution to European energy policy goals, i.e., sustainability, competitiveness and security of supply. Besides technical advances, regulatory framework and ownership structures are of crucial importance in order to achieve greater diffusion of the technology in residential applications. This paper analyses the interplay of policy and ownership structures for the future deployment of mCHP. Furthermore, it regards the three country cases Denmark, France and Portugal. Firstly, the implications of different kinds of support schemes on investment risk and the diffusion of a technology are explained conceptually. Secondly, ownership arrangements are addressed. Then, a cross-country comparison on present support schemes for mCHP and competing technologies discusses the national implementation of European legislation in Denmark, France and Portugal. Finally, resulting implications for ownership arrangements on the choice of support scheme are explained. From a conceptual point of view, investment support, feed-in tariffs and price premiums are the most appropriate schemes for fuel cell mCHP. This can be used for improved analysis of operational strategies. The interaction of this plethora of elements necessitates careful balancing from a private- and socio-economic point of view.

Comparing the greenhouse gas emissions from three alternative waste combustion concepts

DOE Office of Scientific and Technical Information (OSTI.GOV)

Vainikka, Pasi, E-mail: pasi.vainikka@vtt.fi; Tsupari, Eemeli; Sipilae, Kai

2012-03-15

Highlights: Black-Right-Pointing-Pointer Significant GHG reductions are possible by efficient WtE technologies. Black-Right-Pointing-Pointer CHP and high power-to-heat ratio provide significant GHG savings. Black-Right-Pointing-Pointer N{sub 2}O and coal mine type are important in LCA GHG emissions of FBC co-combustion. Black-Right-Pointing-Pointer Substituting coal and fuel oil by waste is beneficial in electricity and heat production. Black-Right-Pointing-Pointer Substituting natural gas by waste may not be reasonable in CHP generation. - Abstract: Three alternative condensing mode power and combined heat and power (CHP) waste-to-energy concepts were compared in terms of their impacts on the greenhouse gas (GHG) emissions from a heat and power generation system.more » The concepts included (i) grate, (ii) bubbling fluidised bed (BFB) and (iii) circulating fluidised bed (CFB) combustion of waste. The BFB and CFB take advantage of advanced combustion technology which enabled them to reach electric efficiency up to 35% and 41% in condensing mode, respectively, whereas 28% (based on the lower heating value) was applied for the grate fired unit. A simple energy system model was applied in calculating the GHG emissions in different scenarios where coal or natural gas was substituted in power generation and mix of fuel oil and natural gas in heat generation by waste combustion. Landfilling and waste transportation were not considered in the model. GHG emissions were reduced significantly in all of the considered scenarios where the waste combustion concepts substituted coal based power generation. With the exception of condensing mode grate incinerator the different waste combustion scenarios resulted approximately in 1 Mton of fossil CO{sub 2}-eq. emission reduction per 1 Mton of municipal solid waste (MSW) incinerated. When natural gas based power generation was substituted by electricity from the waste combustion significant GHG emission reductions were not achieved.« less

CHP Integrated with Burners for Packaged Boilers

DOE Office of Scientific and Technical Information (OSTI.GOV)

Castaldini, Carlo; Darby, Eric

2013-09-30

The objective of this project was to engineer, design, fabricate, and field demonstrate a Boiler Burner Energy System Technology (BBEST) that integrates a low-cost, clean burning, gas-fired simple-cycle (unrecuperated) 100 kWe (net) microturbine (SCMT) with a new ultra low-NOx gas-fired burner (ULNB) into one compact Combined Heat and Power (CHP) product that can be retrofit on new and existing industrial and commercial boilers in place of conventional burners. The Scope of Work for this project was segmented into two principal phases: (Phase I) Hardware development, assembly and pre-test and (Phase II) Field installation and demonstration testing. Phase I was dividedmore » into five technical tasks (Task 2 to 6). These tasks covered the engineering, design, fabrication, testing and optimization of each key component of the CHP system principally, ULNB, SCMT, assembly BBEST CHP package, and integrated controls. Phase I work culminated with the laboratory testing of the completed BBEST assembly prior to shipment for field installation and demonstration. Phase II consisted of two remaining technical tasks (Task 7 and 8), which focused on the installation, startup, and field verification tests at a pre-selected industrial plant to document performance and attainment of all project objectives. Technical direction and administration was under the management of CMCE, Inc. Altex Technologies Corporation lead the design, assembly and testing of the system. Field demonstration was supported by Leva Energy, the commercialization firm founded by executives at CMCE and Altex. Leva Energy has applied for patent protection on the BBEST process under the trade name of Power Burner and holds the license for the burner currently used in the product. The commercial term Power Burner is used throughout this report to refer to the BBEST technology proposed for this project. The project was co-funded by the California Energy Commission and the Southern California Gas Company (SCG), a division of Sempra Energy. These match funds were provided via concurrent contracts and investments available via CMCE, Altex, and Leva Energy The project attained all its objectives and is considered a success. CMCE secured the support of GI&E from Italy to supply 100 kW Turbec T-100 microturbines for the project. One was purchased by the project’s subcontractor, Altex, and a second spare was purchased by CMCE under this project. The microturbines were then modified to convert from their original recuperated design to a simple cycle configuration. Replacement low-NOx silo combustors were designed and bench tested in order to achieve compliance with the California Air Resources Board (CARB) 2007 emission limits for NOx and CO when in CHP operation. The converted microturbine was then mated with a low NOx burner provided by Altex via an integration section that allowed flow control and heat recovery to minimize combustion blower requirements; manage burner turndown; and recover waste heat. A new fully integrated control system was designed and developed that allowed one-touch system operation in all three available modes of operation: (1) CHP with both microturbine and burner firing for boiler heat input greater than 2 MMBtu/hr; (2) burner head only (BHO) when the microturbine is under service; and (3) microturbine only when boiler heat input requirements fall below 2 MMBtu/hr. This capability resulted in a burner turndown performance of nearly 10/1, a key advantage for this technology over conventional low NOx burners. Key components were then assembled into a cabinet with additional support systems for generator cooling and fuel supply. System checkout and performance tests were performed in the laboratory. The assembled system and its support equipment were then shipped and installed at a host facility where final performance tests were conducted following efforts to secure fabrication, air, and operating permits. The installed power burner is now in commercial operation and has achieved all the performance goals.« less

Solid oxide fuel cell short stack performance testing - Part A: Experimental analysis and μ-combined heat and power unit comparison

NASA Astrophysics Data System (ADS)

Mastropasqua, L.; Campanari, S.; Brouwer, J.

2017-12-01

The need to experimentally understand the detailed performance of SOFC stacks under operating conditions typical of commercial SOFC systems has prompted this two-part study. The steady state performance of a 6-cell short stack of yttria (Y2O3) stabilised zirconia (YSZ) with Ni/YSZ anodes and composite Sr-doped lanthanum manganite (LaMnO3, LSM)/YSZ cathodes is experimentally evaluated. In Part A, the stack characterisation is carried out by means of sensitivity analyses on the fuel utilisation factor and the steam-to-carbon ratio. Electrical and environmental performances are assessed and the results are compared with a commercial full-scale micro-CHP system, which comprises the same cells. The results show that the measured temperature dynamics of the short stack in a test stand environment are on the order of many minutes; therefore, one cannot neglect temperature dynamics for a precise measurement of the steady state polarisation behaviour. The overall polarisation performance is comparable to that of the full stack employed in the micro-CHP system, confirming the good representation that short-stack analyses can give of the entire SOFC module. The environmental performance is measured verifying the negligible values of NO emissions (<10 ppb) across the whole polarisation curve.

Activity of levofloxacin alone and in combination with a DnaK inhibitor against gram-negative rods, including levofloxacin-resistant strains.

PubMed

Credito, Kim; Lin, Gengrong; Koeth, Laura; Sturgess, Michael A; Appelbaum, Peter C

2009-02-01

Synergy time-kill testing of levofloxacin alone and in combination with CHP-105, a representative DnaK inhibitor, against 50 gram-negative rods demonstrated that 34 of the 50 strains tested showed significant synergy between levofloxacin and CHP-105 after 12 h and 24 h. Fourteen of these 34 organisms were quinolone resistant (levofloxacin MICs of > or =4 microg/ml).

Activity of Levofloxacin Alone and in Combination with a DnaK Inhibitor against Gram-Negative Rods, Including Levofloxacin-Resistant Strains▿

PubMed Central

Credito, Kim; Lin, Gengrong; Koeth, Laura; Sturgess, Michael A.; Appelbaum, Peter C.

2009-01-01

Synergy time-kill testing of levofloxacin alone and in combination with CHP-105, a representative DnaK inhibitor, against 50 gram-negative rods demonstrated that 34 of the 50 strains tested showed significant synergy between levofloxacin and CHP-105 after 12 h and 24 h. Fourteen of these 34 organisms were quinolone resistant (levofloxacin MICs of ≥4 μg/ml). PMID:19015359

A compound herbal preparation (CHP) in the treatment of children with ADHD: a randomized controlled trial.

PubMed

Katz, M; Levine, A Adar; Kol-Degani, H; Kav-Venaki, L

2010-11-01

Evaluation of the efficacy of a patented, compound herbal preparation (CHP) in improving attention, cognition, and impulse control in children with ADHD. A randomized, double-blind, placebo-controlled trial. University-affiliated tertiary medical center. 120 children newly diagnosed with ADHD, meeting DSM-IV criteria. Random assignment to the herbal treatment group (n = 80) or control group (placebo; n = 40); 73 patients in the treatment group (91%) and 19 in the control group (48%) completed the 4-month trial. Test of Variables of Attention (TOVA) administered before and after the treatment period; overall score and 4 subscales. The treatment group showed substantial, statistically significant improvement in the 4 subscales and overall TOVA scores, compared with no improvement in the control group, which persisted in an intention-to-treat analysis. The well-tolerated CHP demonstrated improved attention, cognition, and impulse control in the intervention group, indicating promise for ADHD treatment in children.

Operation reliability analysis of independent power plants of gas-transmission system distant production facilities

NASA Astrophysics Data System (ADS)

Piskunov, Maksim V.; Voytkov, Ivan S.; Vysokomornaya, Olga V.; Vysokomorny, Vladimir S.

2015-01-01

The new approach was developed to analyze the failure causes in operation of linear facilities independent power supply sources (mini-CHP-plants) of gas-transmission system in Eastern part of Russia. Triggering conditions of ceiling operation substance temperature at condenser output were determined with mathematical simulation use of unsteady heat and mass transfer processes in condenser of mini-CHP-plants. Under these conditions the failure probability in operation of independent power supply sources is increased. Influence of environmental factors (in particular, ambient temperature) as well as output electric capability values of power plant on mini-CHP-plant operation reliability was analyzed. Values of mean time to failure and power plant failure density during operation in different regions of Eastern Siberia and Far East of Russia were received with use of numerical simulation results of heat and mass transfer processes at operation substance condensation.

Researching of the possibility of using absorption heat exchangers for creating the low return temperature heat supply systems based on CHP generation

NASA Astrophysics Data System (ADS)

Yavorovsky, Y. V.; Malenkov, A. S.; Zhigulina, Y. V.; Romanov, D. O.; Kurzanov, S. Y.

2017-11-01

This paper deals with the variant of modernization of the heat point within urban heat supply network in order to create the system of heat and cold supply on its basis, providing the suppliers with heat in cold months and with heat and cold in warm months. However, in cold months in the course of heating system operation, the reverse delivery water temperature is maintained below 40 °C. The analysis of heat and power indicators of the heat and cold supply system under different operating conditions throughout the year was conducted. The possibility to use the existing heat networks for the cold supply needs was estimated. The advantages of the system over the traditional heat supply systems that use Combined Heat and Power (CHP) plant as a heat source as exemplified by heat supply system from CHP with ST-80 turbine were demonstrated.

DOE Office of Scientific and Technical Information (OSTI.GOV)

HADLEY, S.W.

This document was prepared at the request of the U.S. Department of Energy's (DOE's) Federal Energy Management Program (FEMP) under its Technical Guidance and Assistance and Project Financing Programs. The purpose was to provide an estimate of the national potential for combined heat and power (also known as CHP; cogeneration; or cooling, heating, and power) applications at federal facilities and the associated costs and benefits including energy and emission savings. The report provides a broad overview for the U.S. Department of Energy (DOE) and other agencies on when and where CHP systems are most likely to serve the government's bestmore » interest. FEMP's mission is to reduce the cost to and environmental impact of the federal government by advancing energy efficiency and water conservation, promoting the use of renewable energy, and improving utility management decisions at federal sites. FEMP programs are driven by its customers: federal agency sites. FEMP monitors energy efficiency and renewable energy technology developments and mounts ''technology-specific'' programs to make technologies that are in strong demand by agencies more accessible. FEMP's role is often one of helping the federal government ''lead by example'' through the use of advanced energy efficiency/renewable energy (EERE) technologies in its own buildings and facilities. CHP was highlighted in the Bush Administration's National Energy Policy Report as a commercially available technology offering extraordinary benefits in terms of energy efficiencies and emission reductions. FEMP's criteria for emphasizing a technology are that it must be commercially available; be proven but underutilized; have a strong constituency and momentum; offer large energy savings and other benefits of interest to federal sites and FEMP mission; be in demand; and carry sufficient federal market potential. As discussed in the report, CHP meets all of these criteria. Executive Order 13123 directs federal facilities to use CHP when life-cycle costs indicate energy reduction goals will be met. FEMP can assist facilities to conduct this analysis. The model developed for this report estimates the magnitude of CHP that could be implemented under various performance and economic assumptions associated with different applications. This model may be useful for other energy technologies. It can be adapted to estimate the market potential in federal buildings for any energy system based on the cost and performance parameters that a user desires to assess. The model already incorporates a standard set of parameters based on available data for federal buildings including total building space, building type, energy use intensity, fuel costs, and the performance of many prime movers commonly used in CHP applications. These and other variables can be adjusted to meet user needs or updated in the future as new data become available.« less

Fabrication of biocompatible hydrogel coatings for implantable medical devices using Fenton-type reaction.

PubMed

Butruk, Beata; Trzaskowski, Maciej; Ciach, Tomasz

2012-08-01

In this paper the authors present a simple method of coating polyurethane (PU) surface with poly(vinyl pirrolidone) (PVP) hydrogel. The hydrogel-coated materials were designed for use in biomedical applications, especially in blood-contacting devices. The coating is formed due to free radical macromolecular grafting-crosslinking. Polymer surface was first immersed in an organic solution containing radical source: cumene hydroperoxide (CHP) with an addition of a branching and anchoring agent: ethylene glycol dimethylacrylate (EGDMA). In the second step, the substrate was immersed in a water solution containing given concentration of PVP and Fe(2+). The novelty of the process consists in the fact that free radicals are formed mostly at the polymer/solution interface, what assures high grafting efficiency together with the formation of covalent bonds between polymer substrate and modifying layer. The process was optimized for reagents concentrations. The coating properties: thickness and the swelling ratio were strongly influenced by CHP, Fe(2+), PVP and EGMDA concentrations. The chemical composition of the surface analyzed with FTIR-ATR spectroscopy confirmed the presence of PVP coating. In vitro biocompatibility tests with L929 fibroblasts confirmed non-cytotoxicity of the coatings. Hydrogel coating significantly improved polyurethane hemocompatibility. Studies with human whole blood revealed that both, the platelet consumption and the level of platelet activation were as low as for negative control. Copyright © 2012 Elsevier B.V. All rights reserved.

Policy implications of allocation methods in the life cycle analysis of integrated corn and corn stover ethanol production

DOE PAGES

Canter, Christina E.; Dunn, Jennifer B.; Han, Jeongwoo; ...

2015-08-18

Here, a biorefinery may produce multiple fuels from more than one feedstock. The ability of these fuels to qualify as one of the four types of biofuels under the US Renewable Fuel Standard and to achieve a low carbon intensity score under California’s Low Carbon Fuel Standard can be strongly influenced by the approach taken to their life cycle analysis (LCA). For example, in facilities that may co-produce corn grain and corn stover ethanol, the ethanol production processes can share the combined heat and power (CHP) that is produced from the lignin and liquid residues from stover ethanol production. Wemore » examine different LCA approaches to corn grain and stover ethanol production considering different approaches to CHP treatment. In the baseline scenario, CHP meets the energy demands of stover ethanol production first, with additional heat and electricity generated sent to grain ethanol production. The resulting greenhouse gas (GHG) emissions for grain and stover ethanol are 57 and 25 g-CO 2eq/MJ, respectively, corresponding to a 40 and 74% reduction compared to the GHG emissions of gasoline. We illustrate that emissions depend on allocation of burdens of CHP production and corn farming, along with the facility capacities. Co-product handling techniques can strongly influence LCA results and should therefore be transparently documented.« less

Sorption Mechanisms of Antibiotic Cephapirin onto Quartz and Feldspar by Raman Spectroscopy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Peterson, Jonathan; Wang, Wei; Gu, Baohua

2009-01-01

Raman spectroscopy was used to investigate the sorption mechanisms of cephapirin (CHP), a veterinary antibiotic, onto quartz (SiO2) and feldspar (KAlSi3O8) at different pH values. Depending on the charge and surface properties of the mineral, different reaction mechanisms including electrostatic attraction, monodentate and bidentate complexation were found to be responsible for CHP sorption. The zwitterion (CHPo) adsorbs to a quartz(+) surface by electrostatic attraction of the carboxylate anion group ( COO-) at a low pH, but adsorbs to a quartz(-) surface through electrostatic attraction of the pyridinium cation and possibly COO- bridge complexes at relatively higher pH conditions. CHP- bondsmore » to a quartz(-) surface by bidentate complexation between one oxygen of COO- and oxygen from the carbonyl (C=O) of the acetoxymethyl group. On a feldspar surface of mixed charge, CHPo forms monodentate complexes between C=O as well as COO- bridging complexes or electrostatically attached to localized edge (hydr)oxy-Al surfaces. CHP- adsorbs to feldspar(-) through monodentate C=O complexation, and similar mechanisms may operate for the sorption of other cephalosporins. This research demonstrates, for the first time, that Raman spectroscopic techniques can be effective for evaluating the sorption processes and mechanisms of cephalosporin antibiotics even at relatively low sorbed concentrations (97-120 μmol/kg).« less

Policy implications of allocation methods in the life cycle analysis of integrated corn and corn stover ethanol production

DOE Office of Scientific and Technical Information (OSTI.GOV)

Canter, Christina E.; Dunn, Jennifer B.; Han, Jeongwoo

Here, a biorefinery may produce multiple fuels from more than one feedstock. The ability of these fuels to qualify as one of the four types of biofuels under the US Renewable Fuel Standard and to achieve a low carbon intensity score under California’s Low Carbon Fuel Standard can be strongly influenced by the approach taken to their life cycle analysis (LCA). For example, in facilities that may co-produce corn grain and corn stover ethanol, the ethanol production processes can share the combined heat and power (CHP) that is produced from the lignin and liquid residues from stover ethanol production. Wemore » examine different LCA approaches to corn grain and stover ethanol production considering different approaches to CHP treatment. In the baseline scenario, CHP meets the energy demands of stover ethanol production first, with additional heat and electricity generated sent to grain ethanol production. The resulting greenhouse gas (GHG) emissions for grain and stover ethanol are 57 and 25 g-CO 2eq/MJ, respectively, corresponding to a 40 and 74% reduction compared to the GHG emissions of gasoline. We illustrate that emissions depend on allocation of burdens of CHP production and corn farming, along with the facility capacities. Co-product handling techniques can strongly influence LCA results and should therefore be transparently documented.« less

Brentuximab Vedotin in the Front-Line Treatment of Patients With CD30+ Peripheral T-Cell Lymphomas: Results of a Phase I Study

PubMed Central

Fanale, Michelle A.; Horwitz, Steven M.; Forero-Torres, Andres; Bartlett, Nancy L.; Advani, Ranjana H.; Pro, Barbara; Chen, Robert W.; Davies, Andrew; Illidge, Tim; Huebner, Dirk; Kennedy, Dana A.; Shustov, Andrei R.

2014-01-01

Purpose Front-line treatment of peripheral T-cell lymphomas (PTCL) involves regimens such as cyclophosphamide, doxorubicin, vincristine, prednisone (CHOP) and results in a 5-year overall survival (OS) rate of less than 50%. This phase I open-label study evaluated the safety and activity of brentuximab vedotin administered sequentially with CHOP or in combination with CHP (CHOP without vincristine) as front-line treatment in patients with CD30+ PTCL. Patients and Methods Patients received sequential treatment (once every 3 weeks) with brentuximab vedotin 1.8 mg/kg (two cycles) followed by CHOP (six cycles) or brentuximab vedotin 1.8 mg/kg plus CHP (BV+CHP) for six cycles (once every 3 weeks). Responders received single-agent brentuximab vedotin for eight to 10 additional cycles (for a total of 16 cycles). The primary objective was assessment of safety; secondary end points included objective response rate, complete remission (CR) rate, progression-free survival rate (PFS), and OS. There were no prespecified comparisons of the two treatment approaches. Results After sequential treatment, 11 (85%) of 13 patients achieved an objective response (CR rate, 62%; estimated 1-year PFS rate, 77%). Grade 3/4 adverse events occurred in eight (62%) of 13 patients. At the end of combination treatment, all patients (n = 26) achieved an objective response (CR rate, 88%; estimated 1-year PFS rate, 71%). All seven patients without anaplastic large-cell lymphoma achieved CR. Grade 3/4 adverse events (≥ 10%) in the combination-treatment group were febrile neutropenia (31%), neutropenia (23%), anemia (15%), and pulmonary embolism (12%). Conclusion Brentuximab vedotin, administered sequentially with CHOP or in combination with CHP, had a manageable safety profile and exhibited substantial antitumor activity in newly diagnosed patients with CD30+ PTCL. A randomized phase III trial is under way, comparing BV+CHP with CHOP (clinical trial No. NCT01777152). PMID:25135998

EPA RE-Powering America's Lands: Kansas City Municipal Farm Site ₋ Biomass Power Analysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hunsberger, R.; Mosey, G.

2015-01-01

Through the RE-Powering America's Land initiative, the economic and technical feasibility of utilizing biomass at the Kansas City, Missouri, Municipal Farm site, a group of City-owned properties, is explored. The study that none of the technologies we reviewed--biomass heat, power and CHP--are economically viable options for the Municipal Farms site. However, if the site were to be developed around a future central biomass heating or CHP facility, biomass could be a good option for the site.

KMgene: a unified R package for gene-based association analysis for complex traits.

PubMed

Yan, Qi; Fang, Zhou; Chen, Wei; Stegle, Oliver

2018-02-09

In this report, we introduce an R package KMgene for performing gene-based association tests for familial, multivariate or longitudinal traits using kernel machine (KM) regression under a generalized linear mixed model (GLMM) framework. Extensive simulations were performed to evaluate the validity of the approaches implemented in KMgene. http://cran.r-project.org/web/packages/KMgene. qi.yan@chp.edu or wei.chen@chp.edu. Supplementary data are available at Bioinformatics online. © The Author(s) 2018. Published by Oxford University Press.

Thermodynamics Analysis of Binary Plant Generating Power from Low-Temperature Geothermal Resource

NASA Astrophysics Data System (ADS)

Maksuwan, A.

2018-05-01

The purpose in this research was to predict tendency of increase Carnot efficiency of the binary plant generating power from low-temperature geothermal resource. Low-temperature geothermal resources or less, are usually exploited by means of binary-type energy conversion systems. The maximum efficiency is analyzed for electricity production of the binary plant generating power from low-temperature geothermal resource becomes important. By using model of the heat exchanger equivalent to a power plant together with the calculation of the combined heat and power (CHP) generation. The CHP was solved in detail with appropriate boundary originating an idea from the effect of temperature of source fluid inlet-outlet and cooling fluid supply. The Carnot efficiency from the CHP calculation was compared between condition of increase temperature of source fluid inlet-outlet and decrease temperature of cooling fluid supply. Result in this research show that the Carnot efficiency for binary plant generating power from low-temperature geothermal resource has tendency increase by decrease temperature of cooling fluid supply.

Generation of a head phantom according to the 95th percentile Chinese population data for evaluating the specific absorption rate by wireless communication devices.

PubMed

Ma, Yu; Wang, Yuduo; Shao, Qing; Li, Congsheng; Wu, Tongning

2014-03-01

A Chinese head phantom (CHP) is constructed for evaluating the specific absorption rate (SAR) by the wireless transceivers. The dimensions of the head phantom are within 4 % difference compared with the 95th percentile data from the China's standard. The shell's thickness and the configuration of the pinna are the same as those of the specific anthropomorphic mannequin (SAM). Three computable models for the mobile phones are generated and used in the SAR simulations with the SAM and the CHP. The results show that the simulated SAR from the SAM head is similar. Its morphological reason has been analysed. The authors discuss the conservativeness of the two head phantoms as well. The CHP can be used in the inter-laboratory evaluation for the SAR uncertainty. It can also provide the information for the SAR variability due to physical difference, which will benefit the maintenance and the harmonisation of the standards.

Identification of an operon, Pil-Chp, that controls twitching motility and virulence in Xylella fastidiosa.

PubMed

Cursino, Luciana; Galvani, Cheryl D; Athinuwat, Dusit; Zaini, Paulo A; Li, Yaxin; De La Fuente, Leonardo; Hoch, Harvey C; Burr, Thomas J; Mowery, Patricia

2011-10-01

Xylella fastidiosa is an important phytopathogenic bacterium that causes many serious plant diseases, including Pierce's disease of grapevines. Disease manifestation by X. fastidiosa is associated with the expression of several factors, including the type IV pili that are required for twitching motility. We provide evidence that an operon, named Pil-Chp, with genes homologous to those found in chemotaxis systems, regulates twitching motility. Transposon insertion into the pilL gene of the operon resulted in loss of twitching motility (pilL is homologous to cheA genes encoding kinases). The X. fastidiosa mutant maintained the type IV pili, indicating that the disrupted pilL or downstream operon genes are involved in pili function, and not biogenesis. The mutated X. fastidiosa produced less biofilm than wild-type cells, indicating that the operon contributes to biofilm formation. Finally, in planta the mutant produced delayed and less severe disease, indicating that the Pil-Chp operon contributes to the virulence of X. fastidiosa, presumably through its role in twitching motility.

Ultrasound promoted catalytic liquid-phase dehydrogenation of isopropanol for Isopropanol-Acetone-Hydrogen chemical heat pump.

PubMed

Xu, Min; Xin, Fang; Li, Xunfeng; Huai, Xiulan; Liu, Hui

2015-03-01

The apparent kinetic of the ultrasound assisted liquid-phase dehydrogenation of isopropanol over Raney nickel catalyst was determined in the temperature range of 346-353 K. Comparison of the effects of ultrasound and mechanical agitation on the isopropanol dehydrogenation was investigated. The ultrasound assisted dehydrogenation rate was significantly improved when relatively high power density was used. Moreover, the Isopropanol-Acetone-Hydrogen chemical heat pump (IAH-CHP) with ultrasound irradiation, in which the endothermic reaction is exposure to ultrasound, was proposed. A mathematical model was established to evaluate its energy performance in term of the coefficient of performance (COP) and the exergy efficiency, into which the apparent kinetic obtained in this work was incorporated. The operating performances between IAH-CHP with ultrasound and mechanical agitation were compared. The results indicated that the superiority of the IAH-CHP system with ultrasound was present even if more than 50% of the power of the ultrasound equipment was lost. Copyright © 2014 Elsevier B.V. All rights reserved.

Energetic approach of biomass hydrolysis in supercritical water.

PubMed

Cantero, Danilo A; Vaquerizo, Luis; Mato, Fidel; Bermejo, M Dolores; Cocero, M José

2015-03-01

Cellulose hydrolysis can be performed in supercritical water with a high selectivity of soluble sugars. The process produces high-pressure steam that can be integrated, from an energy point of view, with the whole biomass treating process. This work investigates the integration of biomass hydrolysis reactors with commercial combined heat and power (CHP) schemes, with special attention to reactor outlet streams. The innovation developed in this work allows adequate energy integration possibilities for heating and compression by using high temperature of the flue gases and direct shaft work from the turbine. The integration of biomass hydrolysis with a CHP process allows the selective conversion of biomass into sugars with low heat requirements. Integrating these two processes, the CHP scheme yield is enhanced around 10% by injecting water in the gas turbine. Furthermore, the hydrolysis reactor can be held at 400°C and 23 MPa using only the gas turbine outlet streams. Copyright © 2014 Elsevier Ltd. All rights reserved.

Oral findings in patients with primary Sjögren's syndrome and oral lichen planus--a preliminary study on the effects of bovine colostrum-containing oral hygiene products.

PubMed

Pedersen, A M; Andersen, Torpet L; Reibel, J; Holmstrup, P; Nauntofte, B

2002-03-01

Bovine colostrum is rich in antimicrobial substances and growth factors. The purpose of this open study was to examine and compare the interventory effects of daily use of bovine colostrum-containing oral hygiene products (CHP) on oral symptoms and findings in 20 patients with primary Sjogren's syndrome (pSS) and 20 age-matched patients with oral lichen planus (OLP). Objective oral measures and self-assessment of oral symptoms and general health were conducted before and after 90 days' use of CHP. The pSS patients had more systemic diseases, medication intake, oral dryness, poorer general health and lower salivary secretion than the OLP patients, who had the highest plaque index (PI) and the most mucosal soreness. Oral dryness and soreness were correlated to general health. In both patient groups. unstimulated whole saliva flow rate (UWS) had increased, PI and periodontal pocket depth (PPD) were reduced, and general health and oral dryness and soreness had improved after using CHP. A decrease in hyphae was found in candida smears from both groups and in blastospores in OLP smears. A reduction in the extension of the mucosal lesions was observed in 15 OLP patients. Results suggested beneficial effects of intervention with CHP on oral symptoms, general health, UWS, PI, PPD and candidal load in two patient groups--pSS and OLP--representing different oral symptomatology.

The Design, Construction, and Experimental Evaluation of a Compact Thermoacoustic-Stirling Engine Generator for Use in a micro-CHP Appliance

NASA Astrophysics Data System (ADS)

Wilcox, Douglas A., Jr.

Micro combined heat and power or micro-CHP is the simultaneous generation of useful heat and electricity on a residential scale. The heat and electricity are produced at the point of use, avoiding the distribution losses associated with a centralized power plant. These appliances combine a conventional gas-fired condensing boiler with an electric power module capable of generating electricity from the heat of combustion. Currently, the leading power modules for micro-CHP appliances are free-piston Stirling engines (FPSEs) which can generate 1050 watts of electricity at a thermal-to-electric efficiency of 26%.[1] These external combustion engines have been under development for the last 25 years, with FPSE micro-CHP appliances only recently being introduced to the commercial market. Publications by developers assert unlimited service life and high efficiency, with low noise and emissions; but despite these claims, the actual reliability and cost of manufacturing has prevented their successful mass-market adoption. A Thermoacoustic-Stirling Engine Generator or TaSEG is one possible alternative to FPSE's. A TaSEG uses a thermoacoustic engine, or acoustic heat engine, which can efficiently convert high temperature heat into acoustic power while maintaining a simple design with fewer moving parts than traditional FPSE's. This simpler engine is coupled to an electrodynamic alternator capable of converting acoustic power into electricity. This thesis outlines the design, construction, and experimental evaluation of a TaSEG which is appropriate for integration with a gas burner inside of a residential micro- CHP appliance. The design methodology is discussed, focusing on how changes in the geometry affected the predicted performance. Details of its construction are given and the performance of the TaSEG is then outlined. The TaSEG can deliver 132 watts of electrical output power to an electric load with an overall measured thermal-to-electric (first law) efficiency of eta T-E=8.32%, corresponding to 14% of Carnot etac. The volumetric power density of this TaSEG is 8.9 kW/m3. While the demonstrated overall efficiency is modest (for reasons that are largely understood), this TaSEG has moved the technology away from laboratory prototypes toward a commercially viable power module having a design configuration suitable for implementation in a micro-CHP appliance. Based on the TaSEG's measured experimental performance results, recommendations for future work that might improve the overall efficiency of the TaSEG are also presented.

Life cycle assessment of energy from waste via anaerobic digestion: a UK case study.

PubMed

Evangelisti, Sara; Lettieri, Paola; Borello, Domenico; Clift, Roland

2014-01-01

Particularly in the UK, there is potential for use of large-scale anaerobic digestion (AD) plants to treat food waste, possibly along with other organic wastes, to produce biogas. This paper presents the results of a life cycle assessment to compare the environmental impacts of AD with energy and organic fertiliser production against two alternative approaches: incineration with energy production by CHP and landfill with electricity production. In particular the paper investigates the dependency of the results on some specific assumptions and key process parameters. The input Life Cycle Inventory data are specific to the Greater London area, UK. Anaerobic digestion emerges as the best treatment option in terms of total CO2 and total SO2 saved, when energy and organic fertiliser substitute non-renewable electricity, heat and inorganic fertiliser. For photochemical ozone and nutrient enrichment potentials, AD is the second option while incineration is shown to be the most environmentally friendly solution. The robustness of the model is investigated with a sensitivity analysis. The most critical assumption concerns the quantity and quality of the energy substituted by the biogas production. Two key issues affect the development and deployment of future anaerobic digestion plants: maximising the electricity produced by the CHP unit fuelled by biogas and to defining the future energy scenario in which the plant will be embedded. Copyright © 2013 Elsevier Ltd. All rights reserved.

Tempest gas turbine extends EGT product line

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chellini, R.

With the introduction of the 7.8 MW (mechanical output) Tempest gas turbine, ECT has extended the company`s line of its small industrial turbines. The new Tempest machine, featuring a 7.5 MW electric output and a 33% thermal efficiency, ranks above the company`s single-shaft Typhoon gas turbine, rated 3.2 and 4.9 MW, and the 6.3 MW Tornado gas turbine. All three machines are well-suited for use in combined heat and power (CHP) plants, as demonstrated by the fact that close to 50% of the 150 Typhoon units sold are for CHP applications. This experience has induced EGT, of Lincoln, England, tomore » announce the introduction of the new gas turbine prior to completion of the testing program. The present single-shaft machine is expected to be used mainly for industrial trial cogeneration. This market segment, covering the needs of paper mills, hospitals, chemical plants, ceramic industry, etc., is a typical local market. Cogeneration plants are engineered according to local needs and have to be assisted by local organizations. For this reason, to efficiently cover the world market, EGT has selected a number of associates that will receive from Lincoln completely engineered machine packages and will engineer the cogeneration system according to custom requirements. These partners will also assist the customer and dispose locally of the spares required for maintenance operations.« less

Progress along developmental tracks for electronic health records implementation in the United States

PubMed Central

Hollar, David W

2009-01-01

The development and implementation of electronic health records (EHR) have occurred slowly in the United States. To date, these approaches have, for the most part, followed four developmental tracks: (a) Enhancement of immunization registries and linkage with other health records to produce Child Health Profiles (CHP), (b) Regional Health Information Organization (RHIO) demonstration projects to link together patient medical records, (c) Insurance company projects linked to ICD-9 codes and patient records for cost-benefit assessments, and (d) Consortia of EHR developers collaborating to model systems requirements and standards for data linkage. Until recently, these separate efforts have been conducted in the very silos that they had intended to eliminate, and there is still considerable debate concerning health professionals access to as well as commitment to using EHR if these systems are provided. This paper will describe these four developmental tracks, patient rights and the legal environment for EHR, international comparisons, and future projections for EHR expansion across health networks in the United States. PMID:19291284

The Influence of a CO2 Pricing Scheme on Distributed Energy Resources in California's Commercial Buildings

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stadler, Michael; Marnay, Chris; Lai, Judy

2010-06-01

The Ernest Orlando Lawrence Berkeley National Laboratory (LBNL) is working with the California Energy Commission (CEC) to determine the potential role of commercial-sector distributed energy resources (DER) with combined heat and power (CHP) in greenhouse gas emissions (GHG) reductions. Historically, relatively little attention has been paid to the potential of medium-sized commercial buildings with peak electric loads ranging from 100 kW to 5 MW. In our research, we examine how these medium-sized commercial buildings might implement DER and CHP. The buildings are able to adopt and operate various technologies, e.g., photovoltaics (PV), on-site thermal generation, heat exchangers, solar thermal collectors,more » absorption chillers, batteries and thermal storage systems. We apply the Distributed Energy Resources Customer Adoption Model (DER-CAM), which is a mixed-integer linear program (MILP) that minimizes a site?s annual energy costs and/or CO2 emissions. Using 138 representative mid-sized commercial sites in California, existing tariffs of major utilities, and expected performance data of available technologies in 2020, we find the GHG reduction potential for these buildings. We compare different policy instruments, e.g., a CO2 pricing scheme or a feed-in tariff (FiT), and show their contributions to the California Air Resources Board (CARB) goals of additional 4 GW CHP capacities and 6.7 Mt/a GHG reduction in California by 2020. By applying different price levels for CO2, we find that there is competition between fuel cells and PV/solar thermal. It is found that the PV/solar thermal adoption increases rapidly, but shows a saturation at high CO2 prices, partly due to limited space for PV and solar thermal. Additionally, we find that large office buildings are good hosts for CHP in general. However, most interesting is the fact that fossil-based CHP adoption also increases with increasing CO2 prices. We will show service territory specific results since the attractiveness of DER varies widely by climate zone and service territory.« less

Variations of biomarkers response in mussels Mytilus galloprovincialis to low, moderate and high concentrations of organic chemicals and metals.

PubMed

Perić, Lorena; Nerlović, Vedrana; Žurga, Paula; Žilić, Luka; Ramšak, Andreja

2017-05-01

The changes of acetylcholinesterase activity (AChE), metallothioneins content (MTs), catalase activity (CAT) and lipid peroxidation (LPO) were assessed after 4 days exposure of mussels Mytilus galloprovincialis to a wide range of sublethal concentrations of chlorpyrifos (CHP, 0.03-100 μg/L), benzo(a)pyrene (B(a)P, 0.01-100 μg/L), cadmium (Cd, 0.2-200 μg/L) and copper (Cu, 0.2-100 μg/L). The activity of AChE in the gills decreased after exposure to CHP and Cu, whereas no change of activity was detected after exposure to B(a)P and Cd. Both induction and decrease of MTs content in digestive gland occurred after exposure to CHP and B(a)P, while a marked increase was evident at highest exposure concentrations of Cd. The content of MTs progressively decreased of MTs with increasing concentration of Cu. CAT activity and LPO in the gills did not change after exposure to any of the chemicals. The results demonstrate different response profile in relation to the type of chemical compound, and highlight the potential implications for evaluation of biological effect of contaminants in marine environment. Furthermore, the AChE activity in the gills and MTs content in the digestive gland could be modulated by CHP and Cu at environmentally relevant concentrations indicating the potential risks of short-term transient mussels exposure that may occur due to run-off from land or accidental releases. Copyright © 2017 Elsevier Ltd. All rights reserved.

Surface and mid-water sources of organic carbon by photoautotrophic and chemoautotrophic production in the Black Sea

NASA Astrophysics Data System (ADS)

Yılmaz, Ayşen; Çoban-Yıldız, Yeşim; Telli-Karakoç, Fatma; Bologa, Alexandru

2006-08-01

The multilayered surface waters of the Black Sea contain aerobic, suboxic and anoxic layers that support both photoautotrophic (PP) and chemoautotrophic (ChP) biological production. During the R/V Knorr cruise in May-June 2001, phytoplankton biomass (represented as chlorophyll- a), photoautotrophic and chemoautotrophic production (ChP) rates were determined in the western Black Sea. Integrated chlorophyll- a concentrations in the euphotic zone were as low as 2.2 mg m -2 in the central gyre, while they were as high as 19.9 mg m -2 in the NW shelf region. Integrated photoautotrophic production rates ranged from 112 to 355 mg C m -2 d -1. The lowest values were determined in the central gyre and the highest values were found at the shelf-break station near the Bosphorus, the NW shelf/shelf-break area and in the Sevastopol eddy. Primary production and chlorophyll- a data revealed that post-bloom conditions existed during this sampling period. Bioassay experiments showed that under optimum light conditions, photoautotrophic production was nitrogen-limited. ChP increased in the redox transition zone and coincided with the lower boundary of the fine particle layer. The maximum values were shallower (at σθ=16.25) in the central gyre and deeper (at σθ=16.5) in the shelf-break region near Sakarya Canyon. Integrated ChP rates were 63 and 1930 mg C m -2 d -1, which were equivalent to 30% and 89% of the overall water-column production for the central gyre and Sakarya Canyon regions, respectively.

Thermal-economic optimisation of a CHP gas turbine system by applying a fit-problem genetic algorithm

NASA Astrophysics Data System (ADS)

Ferreira, Ana C. M.; Teixeira, Senhorinha F. C. F.; Silva, Rui G.; Silva, Ângela M.

2018-04-01

Cogeneration allows the optimal use of the primary energy sources and significant reductions in carbon emissions. Its use has great potential for applications in the residential sector. This study aims to develop a methodology for thermal-economic optimisation of small-scale micro-gas turbine for cogeneration purposes, able to fulfil domestic energy needs with a thermal power out of 125 kW. A constrained non-linear optimisation model was built. The objective function is the maximisation of the annual worth from the combined heat and power, representing the balance between the annual incomes and the expenditures subject to physical and economic constraints. A genetic algorithm coded in the java programming language was developed. An optimal micro-gas turbine able to produce 103.5 kW of electrical power with a positive annual profit (i.e. 11,925 €/year) was disclosed. The investment can be recovered in 4 years and 9 months, which is less than half of system lifetime expectancy.

Assessment of Novel Routes of Biomethane Utilization in a Life Cycle Perspective

PubMed Central

Moghaddam, Elham Ahmadi; Ahlgren, Serina; Nordberg, Åke

2016-01-01

Biomethane, as a replacement for natural gas, reduces the use of fossil-based sources and supports the intended change from fossil to bio-based industry. The study assessed different biomethane utilization routes for production of methanol, dimethyl ether (DME), and ammonia, as fuel or platform chemicals and combined heat and power (CHP). Energy efficiency and environmental impacts of the different pathways was studied in a life cycle perspective covering the technical system from biomass production to the end product. Among the routes studied, CHP had the highest energy balance and least environmental impact. DME and methanol performed competently in energy balance and environmental impacts in comparison with the ammonia route. DME had the highest total energy output, as fuel, heat, and steam, among the different routes studied. Substituting the bio-based routes for fossil-based alternatives would give a considerable reduction in environmental impacts such as global warming potential and acidification potential for all routes studied, especially CHP, DME, and methanol. Eutrophication potential was mainly a result of biomass and biomethane production, with marginal differences between the different routes. PMID:28066762

Voltammetric determination of homocysteine using multiwall carbon nanotube paste electrode in the presence of chlorpromazine as a mediator.

PubMed

Gholami-Orimi, Fathali; Taleshi, Farshad; Biparva, Pourya; Karimi-Maleh, Hassan; Beitollahi, Hadi; Ebrahimi, Hamid R; Shamshiri, Mohamad; Bagheri, Hasan; Fouladgar, Masoud; Taherkhani, Ali

2012-01-01

We propose chlorpromazine (CHP) as a new mediator for the rapid, sensitive, and highly selective voltammetric determination of homocysteine (Hcy) using multiwall carbon nanotube paste electrode (MWCNTPE). The experimental results showed that the carbon nanotube paste electrode has a highly electrocatalytic activity for the oxidation of Hcy in the presence of CHP as a mediator. Cyclic voltammetry, double potential step chronoamperometry, and square wave voltammetry (SWV) are used to investigate the suitability of CHP at the surface of MWCNTPE as a mediator for the electrocatalytic oxidation of Hcy in aqueous solutions. The kinetic parameters of the system, including electron transfer coefficient, and catalytic rate constant were also determined using the electrochemical approaches. In addition, SWV was used for quantitative analysis. SWV showed wide linear dynamic range (0.1-210.0 μM Hcy) with a detection limit of 0.08 μM Hcy. Finally, this method was also examined as a selective, simple, and precise electrochemical sensor for the determination of Hcy in real samples.

Voltammetric Determination of Homocysteine Using Multiwall Carbon Nanotube Paste Electrode in the Presence of Chlorpromazine as a Mediator

PubMed Central

Gholami-Orimi, Fathali; Taleshi, Farshad; Biparva, Pourya; Karimi-Maleh, Hassan; Beitollahi, Hadi; Ebrahimi, Hamid R.; Shamshiri, Mohamad; Bagheri, Hasan; Fouladgar, Masoud; Taherkhani, Ali

2012-01-01

We propose chlorpromazine (CHP) as a new mediator for the rapid, sensitive, and highly selective voltammetric determination of homocysteine (Hcy) using multiwall carbon nanotube paste electrode (MWCNTPE). The experimental results showed that the carbon nanotube paste electrode has a highly electrocatalytic activity for the oxidation of Hcy in the presence of CHP as a mediator. Cyclic voltammetry, double potential step chronoamperometry, and square wave voltammetry (SWV) are used to investigate the suitability of CHP at the surface of MWCNTPE as a mediator for the electrocatalytic oxidation of Hcy in aqueous solutions. The kinetic parameters of the system, including electron transfer coefficient, and catalytic rate constant were also determined using the electrochemical approaches. In addition, SWV was used for quantitative analysis. SWV showed wide linear dynamic range (0.1–210.0 μM Hcy) with a detection limit of 0.08 μM Hcy. Finally, this method was also examined as a selective, simple, and precise electrochemical sensor for the determination of Hcy in real samples. PMID:22675657

Hybrid electrospun chitosan-phospholipids nanofibers for transdermal drug delivery.

PubMed

Mendes, Ana C; Gorzelanny, Christian; Halter, Natalia; Schneider, Stefan W; Chronakis, Ioannis S

2016-08-20

Chitosan (Ch) polysaccharide was mixed with phospholipids (P) to generate electrospun hybrid nanofibers intended to be used as platforms for transdermal drug delivery. Ch/P nanofibers exibithed average diameters ranging from 248±94nm to 600±201nm, depending on the amount of phospholipids used. Fourier Transformed Infra-Red (FTIR) spectroscopy and Dynamic Light Scattering (DLS) data suggested the occurrence of electrostatic interactions between amine groups of chitosan with the phospholipid counterparts. The nanofibers were shown to be stable for at least 7days in Phosphate Buffer Saline (PBS) solution. Cytotoxicity studies (WST-1 and LDH assays) demonstrated that the hybrid nanofibers have suitable biocompatibility. Fluorescence microscopy, also suggested that L929 cells seeded on top of the CH/P hybrid have similar metabolic activity comparatively to the cells seeded on tissue culture plate (control). The release of curcumin, diclofenac and vitamin B12, as model drugs, from Ch/P hybrid nanofibers was investigated, demonstrating their potential utilization as a transdermal drug delivery system. Copyright © 2016 Elsevier B.V. All rights reserved.

Industrial Scale Energy Systems Integration; NREL (National Renewable Energy Laboratory)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ruth, Mark

2015-07-28

The industrial sector consumes 25% of the total energy in the U.S. and produces 18% of the greenhouse gas (GHG) emissions. Energy Systems Integration (ESI) opportunities can reduce those values and increase the profitability of that sector. This presentation outlines several options. Combined heat and power (CHP) is an option that is available today for many applications. In some cases, it can be extended to trigeneration by adding absorbtion cooling. Demand response is another option in use by the industrial sector - in 2012, industry provided 47% of demand response capacity. A longer term option that combines the benefits ofmore » CHP with those of demand response is hybrid energy systems (HESs). Two possible HESs are described and development implications discussed. extended to trigeneration by adding absorbtion cooling. Demand response is another option in use by the industrial sector - in 2012, industry provided 47% of demand response capacity. A longer term option that combines the benefits of CHP with those of demand response is hybrid energy systems (HESs). Two possible HESs are described and development implications discussed.« less

One-Step Printable Perovskite Films Fabricated under Ambient Conditions for Efficient and Reproducible Solar Cells.

PubMed

Jung, Yen-Sook; Hwang, Kyeongil; Heo, Youn-Jung; Kim, Jueng-Eun; Lee, Donmin; Lee, Cheol-Ho; Joh, Han-Ik; Yeo, Jun-Seok; Kim, Dong-Yu

2017-08-23

Despite the potential of roll-to-roll processing for the fabrication of perovskite films, the realization of highly efficient and reproducible perovskite solar cells (PeSCs) through continuous coating techniques and low-temperature processing is still challenging. Here, we demonstrate that efficient and reliable CH 3 NH 3 PbI 3 (MAPbI 3 ) films fabricated by a printing process can be achieved through synergetic effects of binary processing additives, N-cyclohexyl-2-pyrrolidone (CHP) and dimethyl sulfoxide (DMSO). Notably, these perovskite films are deposited from premixed perovskite solutions for facile one-step processing under a room-temperature and ambient atmosphere. The CHP molecules result in the uniform and homogeneous perovskite films even in the one-step slot-die system, which originate from the high boiling point and low vapor pressure of CHP. Meanwhile, the DMSO molecules facilitate the growth of perovskite grains by forming intermediate states with the perovskite precursor molecules. Consequently, fully printed PeSC based on the binary additive system exhibits a high PCE of 12.56% with a high reproducibility.

Spatial distribution of pollutants in the area of the former CHP plant

NASA Astrophysics Data System (ADS)

Cichowicz, Robert

2018-01-01

The quality of atmospheric air and level of its pollution are now one of the most important issues connected with life on Earth. The frequent nuisance and exceedance of pollution standards often described in the media are generated by both low emission sources and mobile sources. Also local organized energy emission sources such as local boiler houses or CHP plants have impact on air pollution. At the same time it is important to remember that the role of local power stations in shaping air pollution immission fields depends on the height of emitters and functioning of waste gas treatment installations. Analysis of air pollution distribution was carried out in 2 series/dates, i.e. 2 and 10 weeks after closure of the CHP plant. In the analysis as a reference point the largest intersection of streets located in the immediate vicinity of the plant was selected, from which virtual circles were drawn every 50 meters, where 31 measuring points were located. As a result, the impact of carbon dioxide, hydrogen sulfide and ammonia levels could be observed and analyzed, depending on the distance from the street intersection.

Chasing the peak: optimal statistics for weak shear analyses

NASA Astrophysics Data System (ADS)

Smit, Merijn; Kuijken, Konrad

2018-01-01

Context. Weak gravitational lensing analyses are fundamentally limited by the intrinsic distribution of galaxy shapes. It is well known that this distribution of galaxy ellipticity is non-Gaussian, and the traditional estimation methods, explicitly or implicitly assuming Gaussianity, are not necessarily optimal. Aims: We aim to explore alternative statistics for samples of ellipticity measurements. An optimal estimator needs to be asymptotically unbiased, efficient, and robust in retaining these properties for various possible sample distributions. We take the non-linear mapping of gravitational shear and the effect of noise into account. We then discuss how the distribution of individual galaxy shapes in the observed field of view can be modeled by fitting Fourier modes to the shear pattern directly. This allows scientific analyses using statistical information of the whole field of view, instead of locally sparse and poorly constrained estimates. Methods: We simulated samples of galaxy ellipticities, using both theoretical distributions and data for ellipticities and noise. We determined the possible bias Δe, the efficiency η and the robustness of the least absolute deviations, the biweight, and the convex hull peeling (CHP) estimators, compared to the canonical weighted mean. Using these statistics for regression, we have shown the applicability of direct Fourier mode fitting. Results: We find an improved performance of all estimators, when iteratively reducing the residuals after de-shearing the ellipticity samples by the estimated shear, which removes the asymmetry in the ellipticity distributions. We show that these estimators are then unbiased in the absence of noise, and decrease noise bias by more than 30%. Our results show that the CHP estimator distribution is skewed, but still centered around the underlying shear, and its bias least affected by noise. We find the least absolute deviations estimator to be the most efficient estimator in almost all cases, except in the Gaussian case, where it's still competitive (0.83 < η < 5.1) and therefore robust. These results hold when fitting Fourier modes, where amplitudes of variation in ellipticity are determined to the order of 10-3. Conclusions: The peak of the ellipticity distribution is a direct tracer of the underlying shear and unaffected by noise, and we have shown that estimators that are sensitive to a central cusp perform more efficiently, potentially reducing uncertainties by more 0% and significantly decreasing noise bias. These results become increasingly important, as survey sizes increase and systematic issues in shape measurements decrease.

Life cycle analysis of distributed concentrating solar combined heat and power: economics, global warming potential and water

NASA Astrophysics Data System (ADS)

Norwood, Zack; Kammen, Daniel

2012-12-01

We report on life cycle assessment (LCA) of the economics, global warming potential and water (both for desalination and water use in operation) for a distributed concentrating solar combined heat and power (DCS-CHP) system. Detailed simulation of system performance across 1020 sites in the US combined with a sensible cost allocation scheme informs this LCA. We forecast a levelized cost of 0.25 kWh-1 electricity and 0.03 kWh-1 thermal, for a system with a life cycle global warming potential of ˜80 gCO2eq kWh-1 of electricity and ˜10 gCO2eq kWh-1 thermal, sited in Oakland, California. On the basis of the economics shown for air cooling, and the fact that any combined heat and power system reduces the need for cooling while at the same time boosting the overall solar efficiency of the system, DCS-CHP compares favorably to other electric power generation systems in terms of minimization of water use in the maintenance and operation of the plant. The outlook for water desalination coupled with distributed concentrating solar combined heat and power is less favorable. At a projected cost of 1.40 m-3, water desalination with DCS-CHP would be economical and practical only in areas where water is very scarce or moderately expensive, primarily available through the informal sector, and where contaminated or salt water is easily available as feed-water. It is also interesting to note that 0.40-1.90 m-3 is the range of water prices in the developed world, so DCS-CHP desalination systems could also be an economical solution there under some conditions.

Impact of individualized pain plan on the emergency management of children with sickle cell disease.

PubMed

Krishnamurti, Lakshmanan; Smith-Packard, Bethanny; Gupta, Ashish; Campbell, Mary; Gunawardena, Sriya; Saladino, Richard

2014-10-01

Vaso-occlusive crisis (VOC) the hallmark of sickle cell disease (SCD) is often treated inadequately in the emergency department (ED). We hypothesized that pain management plans individualized for each patient can improve pain management and lead to high levels of patient satisfaction. Starting in 2002, we treated all patients with SCD reporting to Children's Hospital of Pittsburgh (CHP) ED with VOC using a structured algorithm. We recorded regimens used successfully for each patient as an "individualized pain plan" and implemented it during subsequent VOC visits and adjusted it to patient response. We compared rates of hospitalization following an ED visit with VOC and readmission within 1 week after discharge for CHP with that of four comparable hospitals from Pediatric Health Information (PHIS) database. Patients and parents completed surveys of satisfaction with pain management and with care. Between 2002 and 2008 there was a greater decline in the rate of admission of patients presenting to the ED at CHP (78% to 52%) as compared to PHIS (71% to 68%), (P < 0.05) and readmission rates at CHP (7.3% to 3.2%) as compared to PHIS (6.5% to 5.1%) (P < 0.05). Improvement in pain score during ED management was 2.0 or more on a Wong Baker scale of 0-5 (P < 0.01). Participants on average, rated quality of pain management as very good or higher. Individualized pain management plans in the ED are effective in delivering high quality management of VOC and are associated with a high level of patient satisfaction and decreased avoidable hospitalizations. © 2014 Wiley Periodicals, Inc.

Assessment of Distributed Generation Potential in JapaneseBuildings

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhou, Nan; Marnay, Chris; Firestone, Ryan

2005-05-25

To meet growing energy demands, energy efficiency, renewable energy, and on-site generation coupled with effective utilization of exhaust heat will all be required. Additional benefit can be achieved by integrating these distributed technologies into distributed energy resource (DER) systems (or microgrids). This research investigates a method of choosing economically optimal DER, expanding on prior studies at the Berkeley Lab using the DER design optimization program, the Distributed Energy Resources Customer Adoption Model (DER-CAM). DER-CAM finds the optimal combination of installed equipment from available DER technologies, given prevailing utility tariffs, site electrical and thermal loads, and a menu of available equipment.more » It provides a global optimization, albeit idealized, that shows how the site energy loads can be served at minimum cost by selection and operation of on-site generation, heat recovery, and cooling. Five prototype Japanese commercial buildings are examined and DER-CAM applied to select the economically optimal DER system for each. The five building types are office, hospital, hotel, retail, and sports facility. Based on the optimization results, energy and emission reductions are evaluated. Furthermore, a Japan-U.S. comparison study of policy, technology, and utility tariffs relevant to DER installation is presented. Significant decreases in fuel consumption, carbon emissions, and energy costs were seen in the DER-CAM results. Savings were most noticeable in the sports facility (a very favourable CHP site), followed by the hospital, hotel, and office building.« less

The governance of innovation diffusion - a socio-technical analysis of energy policy

NASA Astrophysics Data System (ADS)

Nolden, C.

2012-10-01

This paper describes a dynamic price mechanism to coordinate eletric power generation from micro Combined Heat and Power (micro-CHP) systems in a network of households. It is assumed that the households are prosumers, i.e. both producers and consumers of electricity. The control is done on household level in a completely distributed manner. Avoiding a centralized controller both eases computation complexity and preserves communication structure in the network. Local information is used to decide to turn on or off the micro-CHP, but through price signals between the prosumers the network as a whole operates in a cooperative way.

The OSHA hazardous chemical occupational exposure standard for laboratories.

PubMed

Armbruster, D A

1991-01-01

OSHA's chemical occupational exposure standard for laboratories is an outgrowth of the previously issued Hazard Communication Standard. The standard relieves laboratories from complying with general industry standards but does require compliance with specific laboratory guidelines. The heart of the standard is the creation of a Chemical Hygiene Plan (CHP). The CHP addresses major issues such as safety equipment and procedures, work practices, training, the designation of a chemical hygiene officer, and the provision of medical consultation and examination for affected employees. This new standard, in full effect as of January 31, 1991, presents yet another regulatory challenge to laboratory managers but also ensures a safer environment for laboratory workers.

The effect of cyclic hydrostatic pressure on the functional development of cartilaginous tissues engineered using bone marrow derived mesenchymal stem cells.

PubMed

Meyer, E G; Buckley, C T; Steward, A J; Kelly, D J

2011-10-01

Mechanical signals can play a key role in regulating the chondrogenic differentiation of mesenchymal stem cells (MSCs). The objective of this study was to determine if the long-term application of cyclic hydrostatic pressure could be used to improve the functional properties of cartilaginous tissues engineered using bone marrow derived MSCs. MSCs were isolated from the femora of two porcine donors, expanded separately under identical conditions, and then suspended in cylindrical agarose hydrogels. Constructs from both donors were maintained in a chemically defined media supplemented with TGF-β3 for 42 days. TGF-β3 was removed from a subset of constructs from day 21 to 42. Loaded groups were subjected to 10 MPa of cyclic hydrostatic pressurisation at 1 Hz for one hour/day, five days/week. Loading consisted either of continuous hydrostatic pressure (CHP) initiated at day 0, or delayed hydrostatic pressure (DHP) initiated at day 21. Free swelling (FS) constructs were cultured in parallel as controls. Constructs were assessed at days 0, 21 and 42. MSCs isolated from both donors were morphologically similar, demonstrated comparable colony forming unit-fibroblast (CFU-F) numbers, and accumulated near identical levels of collagen and GAG following 42 days of free swelling culture. Somewhat unexpectedly the two donors displayed a differential response to hydrostatic pressure. For one donor the application of CHP resulted in increased collagen and GAG accumulation by day 42, resulting in an increased dynamic modulus compared to FS controls. In contrast, CHP had no effect on matrix accumulation for the other donor. The application of DHP had no effect on either matrix accumulation or construct mechanical properties for both donors. Variability in the response to hydrostatic pressure was also observed for three further donors. In conclusion, this study demonstrates that the application of long-term hydrostatic pressure can be used to improve the functional properties of cartilaginous tissues engineered using bone marrow derived MSCs by enhancing collagen and GAG accumulation. The response to such loading however is donor dependent, which has implications for the clinical utilisation of such a stimulus when engineering cartilaginous grafts using autologous MSCs. Copyright © 2011 Elsevier Ltd. All rights reserved.

Operation and planning of coordinated natural gas and electricity infrastructures

NASA Astrophysics Data System (ADS)

Zhang, Xiaping

Natural gas is becoming rapidly the optimal choice for fueling new generating units in electric power system driven by abundant natural gas supplies and environmental regulations that are expected to cause coal-fired generation retirements. The growing reliance on natural gas as a dominant fuel for electricity generation throughout North America has brought the interaction between the natural gas and power grids into sharp focus. The primary concern and motivation of this research is to address the emerging interdependency issues faced by the electric power and natural gas industry. This thesis provides a comprehensive analysis of the interactions between the two systems regarding the short-term operation and long-term infrastructure planning. Natural gas and renewable energy appear complementary in many respects regarding fuel price and availability, environmental impact, resource distribution and dispatchability. In addition, demand response has also held the promise of making a significant contribution to enhance system operations by providing incentives to customers for a more flat load profile. We investigated the coordination between natural gas-fired generation and prevailing nontraditional resources including renewable energy, demand response so as to provide economical options for optimizing the short-term scheduling with the intense natural gas delivery constraints. As the amount and dispatch of gas-fired generation increases, the long-term interdependency issue is whether there is adequate pipeline capacity to provide sufficient gas to natural gas-fired generation during the entire planning horizon while it is widely used outside the power sector. This thesis developed a co-optimization planning model by incorporating the natural gas transportation system into the multi-year resource and transmission system planning problem. This consideration would provide a more comprehensive decision for the investment and accurate assessment for system adequacy and reliability. With the growing reliance on natural gas and widespread utilization of highly efficient combined heat and power (CHP), it is also questionable that whether the independent design of infrastructures can meet potential challenges of future energy supply. To address this issue, this thesis proposed an optimization framework for a sustainable multiple energy system expansion planning based on an energy hub model while considering the energy efficiency, emission and reliability performance. In addition, we introduced the probabilistic reliability evaluation and flow network analysis into the multiple energy system design in order to obtain an optimal and reliable network topology.

Putney Basketville Site Biomass CHP Analysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hunsberger, Randolph; Mosey, Gail

2013-10-01

The U.S. Environmental Protection Agency (EPA) Office of Solid Waste and Emergency Response Center for Program Analysis developed the RE-Powering America's Land initiative to reuse contaminated sites for renewable energy generation when aligned with the community's vision for the site. The Putney, Vermont, Basketville site, formerly the location of a basket-making facility and a paper mill andwoolen mill, was selected for a feasibility study under the program. Biomass was chosen as the renewable energy resource based on abundant woody-biomass resources available in the area. Biomass combined heat and power (CHP) was selected as the technology due to nearby loads, includingmore » Putney Paper and Landmark College.« less

Optimizing the Electronic Properties of Photoactive Anticancer Oxypyridine-Bridged Dirhodium(II,II) Complexes

DOE PAGES

Li, Zhanyong; David, Amanda; Albani, Bryan A.; ...

2014-12-01

A series of partial paddlewheel dirhodium compounds of general formula cis-[Rh 2(xhp) 2(CH 3CN) n][BF 4] 2 (n = 5 or 6) were synthesized {xhp = 6-R-2-oxypyridine ligands, R = -CH 3 (mhp), -F (fhp), -Cl (chp)}. X-ray crystallographic studies indicate the aforementioned compounds contain two cis-oriented bridging xhp ligands, with the remaining sites being coordinated by CH 3CN ligands. The lability of the equatorial (eq) CH 3CN groups in these complexes in solution is in the order -CH 3 > -Cl > -F, in accord with the more electron rich bridging ligands exerting a stronger trans effect. In themore » case of cis-[Rh 2(chp) 2(CH 3CN) 6][BF 4] 2 (5), light irradiation enhances the production of the aqua adducts in which eq CH 3CN is replaced by H 2O molecules, whereas the formation of the aqua species for cis-[Rh 2(fhp) 2(CH 3CN) 6][BF 4] 2 (7) is only slightly increased by irradiation. The potential of both compounds to act as photochemotherapy agents was evaluated. A 16.4-fold increase in cytotoxicity against the HeLa cell line was observed for 5 upon 30 min irradiation (λ > 400 nm), in contrast to the nontoxic compound 7, which is in accord with the results from the photochemistry. Furthermore, the cell death mechanism induced by 5 was determined to be apoptosis. In conclusion, these results clearly demonstrate the importance of tuning the ligand field around the dimetal center to maximize the photoreactivity and achieve the best photodynamic action.« less

Limitation of Biofuel Production in Europe from the Forest Market

NASA Astrophysics Data System (ADS)

Leduc, Sylvain; Wetterlund, Elisabeth; Dotzauer, Erik; Kindermann, Georg

2013-04-01

The European Union has set a 10% target for the share of biofuel in the transportation sector to be met by 2020. To reach this target, second generation biofuel is expected to replace 3 to 5% of the transport fossil fuel consumption. But the competition on the feedstock is an issue and makes the planning for the second generation biofuel plant a challenge. Moreover, no commercial second generation biofuel production plant is under operation, but if reaching commercial status, this type of production plants are expected to become very large. In order to minimize the tranportation costs and to takle the competetion for the feedstock against the existing woody based industries, the geographical location of biofuel production plants becomes an issue. This study investigates the potential of second generation biofuel economically feasible in Europe by 2020 in regards with the competition for the feedsstock with the existing woody biomass based industries (CHP, pulp and paper mills, sawmills...). To assess the biofuel potential in Europe, a techno-economic, geographically explicit model, BeWhere, is used. It determines the optimal locations of bio-energy production plants by minimizing the costs and CO2 emissions of the entire supply chain. The existing woody based industries have to first meet their wood demand, and if the amount of wood that remains is suficiant, new bio-energy production plants if any can be set up. Preliminary results show that CHP plants are preferably chosen over biofuel production plants. Strong biofuel policy support is needed in order to consequently increase the biofuel production in Europe. The carbon tax influences the emission reduction to a higher degree than the biofuel support. And the potential of second generation biofuel would at most reach 3% of the European transport fuel if the wood demand does not increase from 2010.

Microgrid to enable optimal distributed energy retail and end-user demand response

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jin, Ming; Feng, Wei; Marnay, Chris

In the face of unprecedented challenges in environmental sustainability and grid resilience, there is an increasingly held consensus regarding the adoption of distributed and renewable energy resources such as microgrids (MGs), and the utilization of flexible electric loads by demand response (DR) to potentially drive a necessary paradigm shift in energy production and consumption patterns. However, the potential value of distributed generation and demand flexibility has not yet been fully realized in the operation of MGs. This study investigates the pricing and operation strategy with DR for a MG retailer in an integrated energy system (IES). Based on co-optimizing retailmore » rates and MG dispatch formulated as a mixed integer quadratic programming (MIQP) problem, our model devises a dynamic pricing scheme that reflects the cost of generation and promotes DR, in tandem with an optimal dispatch plan that exploits spark spread and facilitates the integration of renewables, resulting in improved retailer profits and system stability. Main issues like integrated energy coupling and customer bill reduction are addressed during pricing to ensure rates competitiveness and customer protection. By evaluating on real datasets, the system is demonstrated to optimally coordinate storage, renewables, and combined heat and power (CHP), reduce carbon dioxide emission while maintaining profits, and effectively alleviate the PV curtailment problem. Finally, the model can be used by retailers and MG operators to optimize their operations, as well as regulators to design new utility rates in support of the ongoing transformation of energy systems.« less

Microgrid to enable optimal distributed energy retail and end-user demand response

DOE PAGES

Jin, Ming; Feng, Wei; Marnay, Chris; ...

2018-06-07

In the face of unprecedented challenges in environmental sustainability and grid resilience, there is an increasingly held consensus regarding the adoption of distributed and renewable energy resources such as microgrids (MGs), and the utilization of flexible electric loads by demand response (DR) to potentially drive a necessary paradigm shift in energy production and consumption patterns. However, the potential value of distributed generation and demand flexibility has not yet been fully realized in the operation of MGs. This study investigates the pricing and operation strategy with DR for a MG retailer in an integrated energy system (IES). Based on co-optimizing retailmore » rates and MG dispatch formulated as a mixed integer quadratic programming (MIQP) problem, our model devises a dynamic pricing scheme that reflects the cost of generation and promotes DR, in tandem with an optimal dispatch plan that exploits spark spread and facilitates the integration of renewables, resulting in improved retailer profits and system stability. Main issues like integrated energy coupling and customer bill reduction are addressed during pricing to ensure rates competitiveness and customer protection. By evaluating on real datasets, the system is demonstrated to optimally coordinate storage, renewables, and combined heat and power (CHP), reduce carbon dioxide emission while maintaining profits, and effectively alleviate the PV curtailment problem. Finally, the model can be used by retailers and MG operators to optimize their operations, as well as regulators to design new utility rates in support of the ongoing transformation of energy systems.« less

Preparation of inulin-type fructooligosaccharides using fast protein liquid chromatography coupled with refractive index detection.

PubMed

Li, J; Cheong, K L; Zhao, J; Hu, D J; Chen, X Q; Qiao, C F; Zhang, Q W; Chen, Y W; Li, S P

2013-09-20

A fast protein liquid chromatography coupled with refractive index detection (FPLC-RID) method was firstly developed for preparation and purification of fructooligosaccharides with different degree of polymerization from burdock, Arctium lappa. After extraction with 60% ethanol and decolorization with MCI gel CHP20P, total fructooligosaccharides were purified on Bio-Gel P-2 column eluted with water at the flow rate of 0.3 ml/min, which was the optimized conditions. The obtained fructooligosaccharides with degree of polymerization of 3-9 were identified based on their methylation analysis, MS and NMR data. This method has the advantages of high automation, good recovery and easy performance, which could be used for preparation of FOS from other sources, as well as other targeted compounds without UV absorbance. Copyright © 2013 Elsevier B.V. All rights reserved.

In Situ Imaging of Tissue Remodeling with Collagen Hybridizing Peptides

PubMed Central

2017-01-01

Collagen, the major structural component of nearly all mammalian tissues, undergoes extensive proteolytic remodeling during developmental states and a variety of life-threatening diseases such as cancer, myocardial infarction, and fibrosis. While degraded collagen could be an important marker of tissue damage, it is difficult to detect and target using conventional tools. Here, we show that a designed peptide (collagen hybridizing peptide: CHP), which specifically hybridizes to the degraded, unfolded collagen chains, can be used to image degraded collagen and inform tissue remodeling activity in various tissues: labeled with 5-carboxyfluorescein and biotin, CHPs enabled direct localization and quantification of collagen degradation in isolated tissues within pathologic states ranging from osteoarthritis and myocardial infarction to glomerulonephritis and pulmonary fibrosis, as well as in normal tissues during developmental programs associated with embryonic bone formation and skin aging. The results indicate the general correlation between the level of collagen remodeling and the amount of denatured collagen in tissue and show that the CHP probes can be used across species and collagen types, providing a versatile tool for not only pathology and developmental biology research but also histology-based disease diagnosis, staging, and therapeutic screening. This study lays the foundation for further testing CHP as a targeting moiety for theranostic delivery in various animal models. PMID:28877431

Simple and efficient immobilization of lipase B from Candida antarctica on porous styrene-divinylbenzene beads.

PubMed

Hernandez, Karel; Garcia-Galan, Cristina; Fernandez-Lafuente, Roberto

2011-06-10

Two commercial porous styrene-divinylbenzene beads (Diaion HP20LX and MCI GEL CHP20P) have been evaluated as supports to immobilize lipase B from Candida antarctica (CALB). MCI GEL CHP20P rapidly immobilized the enzyme, permitting a very high loading capacity: around 110mgCALB/wetg of support compared to the 50mg obtained using decaoctyl Sepabeads. Although enzyme specificity of the enzyme immobilized on different supports was quite altered by the support used in the immobilization, specific activity of the enzyme immobilized on MCI GEL CHP20P was always higher than those found using decaoctyl Sepabeads for all assayed substrates. Thus, a CALB biocatalyst having 3-8 folds (depending on the substrate) higher activity/wet gram of support than the commercial Novozym 435 was obtained. Half-live of CAL-Diaion HP20LX at 60°C was 2-3 higher than the one of Novozym 435, it was 30-40 higher in the presence of 50% acetonitrile and it was around 100 folds greater in the presence of 10M hydrogen peroxide. Results indicate that styrene-divinylbenzene supports may be promising alternatives as supports to immobilize CALB. Copyright © 2011 Elsevier Inc. All rights reserved.

Solid oxide fuel cell systems for residential micro-combined heat and power in the UK: Key economic drivers

NASA Astrophysics Data System (ADS)

Hawkes, Adam; Leach, Matthew

The ability of combined heat and power (CHP) to meet residential heat and power demands efficiently offers potentially significant financial and environmental advantages over centralised power generation and heat-provision through natural-gas fired boilers. A solid oxide fuel cell (SOFC) can operate at high overall efficiencies (heat and power) of 80-90%, offering an improvement over centralised generation, which is often unable to utilise waste heat. This paper applies an equivalent annual cost (EAC) minimisation model to a residential solid oxide fuel cell CHP system to determine what the driving factors are behind investment in this technology. We explore the performance of a hypothetical SOFC system—representing expectations of near to medium term technology development—under present UK market conditions. We find that households with small to average energy demands do not benefit from installation of a SOFC micro-CHP system, but larger energy demands do benefit under these conditions. However, this result is sensitive to a number of factors including stack capital cost, energy import and export prices, and plant lifetime. The results for small and average dwellings are shown to reverse under an observed change in energy import prices, an increase in electricity export price, a decrease in stack capital costs, or an improvement in stack lifetime.

Antimicrobial potential of medicaments used in healing process in dogs' teeth with apical periodontitis.

PubMed

Estrela, Carlos; Holland, Roberto; Bernabé, Pedro Felício Estrada; de Souza, Valdir; Estrela, Cyntia R A

2004-01-01

The objective of this study was to evaluate the influence of irrigants on the antimicrobial potential of calcium hydroxide paste in dogs' teeth with apical periodontitis. Forty-eight premolar teeth of adult mongrel dogs had their root canals opened to the oral environment for 6 months. The root canals were prepared and treated with different irrigating solutions and intracanal medicaments, according to the following groups: 1) 2.5% sodium hypochlorite (NaOCl) + calcium hydroxide paste (CHP); 2) 2% chlorhexidine (CHX) + CHP; 3) vinegar + CHP; 4) vinegar + vinegar. In group 4, both the irrigating solution and intracanal medicament were vinegar, which was renewed every 7 days. Each sample was collected by using two paper points maintained in position for 1 min, and individually transported and immersed in 7 mL of Letheen broth (LB), followed by incubation at 37 degrees C for 48 h. Microbial growth was analyzed by two methods: turbidity of the culture medium and subculture on a specific nutrient broth (brain heart infusion). After 21 days, all experimental groups had microbial growth, however, in different percentages: group 1 - 30%; group 2 - 30%; group 3 - 40%; group 4 - 60%. All materials tested had antimicrobial potential; however, the influence of calcium hydroxide paste on the control of microorganisms must be remembered.

Integrating remediation and resource recovery: On the economic conditions of landfill mining

DOE Office of Scientific and Technical Information (OSTI.GOV)

Frändegård, Per, E-mail: per.frandegard@liu.se; Krook, Joakim; Svensson, Niclas

Highlights: • We compare two remediation scenarios; one with resource recovery and one without. • Economic analysis includes relevant direct costs and revenues for the landfill owner. • High degrees of metal and/or combustible contents are important economic factors. • Landfill tax and the access to a CHP can have a large impact on the result. • Combining landfill mining and remediation may decrease the project cost. - Abstract: This article analyzes the economic potential of integrating material separation and resource recovery into a landfill remediation project, and discusses the result and the largest impact factors. The analysis is donemore » using a direct costs/revenues approach and the stochastic uncertainties are handled using Monte Carlo simulation. Two remediation scenarios are applied to a hypothetical landfill. One scenario includes only remediation, while the second scenario adds resource recovery to the remediation project. Moreover, the second scenario is divided into two cases, case A and B. In case A, the landfill tax needs to be paid for re-deposited material and the landfill holder does not own a combined heat and power plant (CHP), which leads to disposal costs in the form of gate fees. In case B, the landfill tax is waived on the re-deposited material and the landfill holder owns its own CHP. Results show that the remediation project in the first scenario costs about €23/ton. Adding resource recovery as in case A worsens the result to −€36/ton, while for case B the result improves to −€14/ton. This shows the importance of landfill tax and the access to a CHP. Other important factors for the result are the material composition in the landfill, the efficiency of the separation technology used, and the price of the saleable material.« less

Design, implementation and evaluation of a community health training program in an integrated problem-based medical curriculum: a fifteen-year experience at the University of Geneva Faculty of Medicine.

PubMed

Chastonay, Philippe; Vu, Nu Viet; Humair, Jean-Paul; Mpinga, Emmanuel Kabengele; Bernheim, Laurent

2012-01-01

In the literature the need for relevance in medical education and training has been stressed. In the last 40 years medical schools have been challenged to train doctors competent to respond to community health needs. In the mid-90s the University of Geneva Faculty of Medicine introduced an integrated medical curriculum. In this initiative a particular emphasis was put in introducing a 6-year longitudinal and multidisciplinary Community Health Program (CHP). The aims of the present article are to describe the conception, elaboration and implementation of the CHP as well as its evolution over 15 years and the evaluation of its outcomes. The CHP was at its origin elaborated by a small group of highly motivated teachers and later on developed by a multi-disciplinary group of primary care physicians, epidemiologists, public health and bio-ethics specialists, occupational health professionals, lawyers and historians. Evaluation of the program outcomes included educational innovations, new developments of the curriculum and interactions between students and the community. The CHP learning objectives and teaching modalities were defined by the multi-disciplinary group in consensus meetings which triggered a collaborative spirit among teachers and facilitated further developments. The evaluation procedures allowed the monitoring of students' satisfaction which remained high over the years, students' active participation which decreased over time and success at certifying exams which was globally as good as in basic life sciences. The evaluation also assessed outcomes such as educational innovations, new developments of the curriculum and interactions between students and the community. As suggested in the literature, our experience shows that the students' direct exposure and practice in the community health environment is an effective training approach to broaden students' education by offering them a community perspective of health and disease.

Design, implementation and evaluation of a community health training program in an integrated problem-based medical curriculum: a fifteen-year experience at the University of Geneva Faculty of Medicine

PubMed Central

Chastonay, Philippe; Vu, Nu Viet; Humair, Jean-Paul; Mpinga, Emmanuel Kabengele; Bernheim, Laurent

2012-01-01

Background In the literature the need for relevance in medical education and training has been stressed. In the last 40 years medical schools have been challenged to train doctors competent to respond to community health needs. In the mid-90s the University of Geneva Faculty of Medicine introduced an integrated medical curriculum. In this initiative a particular emphasis was put in introducing a 6-year longitudinal and multidisciplinary Community Health Program (CHP). Objectives The aims of the present article are to describe the conception, elaboration and implementation of the CHP as well as its evolution over 15 years and the evaluation of its outcomes. Methods The CHP was at its origin elaborated by a small group of highly motivated teachers and later on developed by a multi-disciplinary group of primary care physicians, epidemiologists, public health and bio-ethics specialists, occupational health professionals, lawyers and historians. Evaluation of the program outcomes included educational innovations, new developments of the curriculum and interactions between students and the community. Results The CHP learning objectives and teaching modalities were defined by the multi-disciplinary group in consensus meetings which triggered a collaborative spirit among teachers and facilitated further developments. The evaluation procedures allowed the monitoring of students’ satisfaction which remained high over the years, students’ active participation which decreased over time and success at certifying exams which was globally as good as in basic life sciences. The evaluation also assessed outcomes such as educational innovations, new developments of the curriculum and interactions between students and the community. Conclusion As suggested in the literature, our experience shows that the students’ direct exposure and practice in the community health environment is an effective training approach to broaden students’ education by offering them a community perspective of health and disease. PMID:22778541

Determination of an Effective Perfluorinated Compounds (PFCs) Oxidation Method

NASA Astrophysics Data System (ADS)

Siriwardena, D. P.; Crimi, M.; Holsen, T.; Bellona, C.

2014-12-01

Perfluoroalkyl and polyfluoroalkyl substances (PFASs) are a stable synthetic class of chemicals ubiquitously spread in environmental media (i.e. air, soil, biota, surface water and groundwater). The substances' strong polar carbon-fluorine bonds and their high thermal and chemical stability make them resistant to biological, chemical, and physical degradation. The purpose of this research is to identify the most effective oxidation method to treat perfluorinated compounds (PFCs) and their by-products that is suitable for in situ application. The laboratory oxidation study focuses on the more commonly detected and studied long-chain (C-8) PFAS; perfluorooctanoic acids (PFOA) and perfluorooctane sulfonic acid (PFOS). Existing research evaluating oxidizing treatment effectiveness on perfluoroalkyl sulfoinoic acids (PFSAs) is limited. A review of the literature and results from preliminary studies indicate that activated persulfate and catalyzed hydrogen peroxide propagation (CHP) reactions appear to be promising oxidants for PFOA. It has been demonstrated that the reactivity of superoxide in water increases in the presence of hydrogen peroxide (H2O2) and solids. Superoxide generated in CHP reactions degrades PFOA seemingly similar to superoxide-mediated destruction of the perhalogenated compounds.The goal of this study is to look at conditions that promote generation of superoxide and look at PFASs treatment effectiveness and byproduct generation. CHP reactions are conducted with varying amount of H2O2 and Fe(III) to determine the optimum conditions for PFC degradation. Results will be compared to those of another experiment using manganese dioxide as a CHP catalyst with varied H2O2 concentration to generate superoxide to degrade PFASs. Activated persulfate conditions to be compared include alkaline pH activation, heat activation, and dual oxidation (combined H2O2 and persulfate ). This presentation will focus on a comparison of oxidation effectiveness under the varied reaction conditions as well as on the oxidation intermediates and byproducts generated toward improved understanding of the potential for and limitations of in situ chemical oxidation (ISCO) for treatment of PFCs.

Prescription pattern of Chinese herbal products for heart failure in Taiwan: A population-based study.

PubMed

Tsai, Ming-Yen; Hu, Wen-Long; Lin, Che-Chen; Lee, Yi-Chiao; Chen, Shih-Yu; Hung, Yu-Chiang; Chen, Yung-Hsiang

2017-02-01

Certain Chinese herbal products (CHPs) may protect against the progression of heart failure (HF). However, there is a lack of research regarding the use of CHPs in patients with HF. The aims of this study were to analyze CHPs usage patterns in patients with HF and to identify the frequency and combination of CHPs most commonly used for HF. This retrospective, nationwide, population-based cohort study was conducted using a randomly sampled cohort of one million patients selected from the National Health Insurance Research Database (NHIRD) for the years 2000-2010 in Taiwan. CHP use and the top ten most frequently prescribed formulae and single herbs for treating HF were assessed, including total formulae number and average and frequency of prescriptions. Demographic characteristics, including sex and age at diagnosis of HF, were examined, together with existing comorbidities. The cohort included 19,988 newly diagnosed AD patients, who were given CHP treatment for HF between 2000 and 2010. Among them, female patients (53.3%) and those over 65years old (63.9%) were more likely to use CM. After adjusting for demographic factors, HF patients suffering from coronary artery disease (CAD) were more likely to seek traditional Chinese medicine (TCM) treatment than those with non-TCM users (57.6% vs. 52.6%). Zhi-Gan-Cao-Tang (4.07%) and Danshen (5.13%) were the most frequent formula CHP and single CHP prescribed by TCM practitioners for treating HF, respectively. Most people with HF who consumed CHPs used CHPs to supplement Yang-Qi, nourish the Ying-blood, and strengthen the heart spirit as complementary medicines to relieve HF-related symptoms, in addition to using standard anti-HF treatments. Further large-scale, randomized clinical trials are warranted in order to determine the effectiveness and safety of these herbal medicines. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

Evidence that Na+/H+ exchanger 1 is an ATP-binding protein.

PubMed

Shimada-Shimizu, Naoko; Hisamitsu, Takashi; Nakamura, Tomoe Y; Wakabayashi, Shigeo

2013-03-01

Na(+)/H(+) exchanger (NHE) 1 is a member of the solute carrier superfamily, which regulates intracellular ionic homeostasis. NHE1 is known to require cellular ATP for its activity, despite there being no requirement for energy input from ATP hydrolysis. In this study, we investigated whether NHE1 is an ATP-binding protein. We designed a baculovirus vector carrying both epitope-tagged NHE1 and its cytosolic subunit CHP1, and expressed the functional NHE1-CHP1 complex on the surface of Sf9 insect cells. Using the purified complex protein consisting of NHE1 and CHP1 from Sf9 cells, we examined a photoaffinity labeling reaction with 8-azido-ATP-biotin. UV irradiation promoted the incorporation of 8-azido-ATP into NHE1, but not into CHP1, with an apparent Kd of 29.1 µM in the presence of Mg(2+). The nonlabeled nucleotides ATP, GTP, TTP and CTP all inhibited this crosslinking. However, ATP had the strongest inhibitory effect, with an apparent inhibition constant (IC50) for ATP of 2.2 mM, close to the ATP concentration giving the half-maximal activation of NHE1 activity. Importantly, crosslinking was more strongly inhibited by ATP than by ADP, suggesting that ATP is dissociated from NHE1 upon ATP hydrolysis. Limited proteolysis with thrombin and deletion mutant analysis revealed that the 8-azido-ATP-binding site is within the C-terminal cytoplasmic domain of NHE1. Equilibrium dialysis with NHE1-derived peptides provided evidence that ATP directly binds to the proximal cytoplasmic region (Gly542-Pro598), which is critical for ATP-dependent regulation of NHE1. These findings suggest that NHE1 is an ATP-binding transporter. Thus, ATP may serve as a direct activator of NHE1. © 2013 The Authors Journal compilation © 2013 FEBS.

Energy implications of mechanical and mechanical–biological treatment compared to direct waste-to-energy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cimpan, Ciprian, E-mail: cic@kbm.sdu.dk; Wenzel, Henrik

2013-07-15

Highlights: • Compared systems achieve primary energy savings between 34 and 140 MJ{sub primary}/100 MJ{sub input} {sub waste.} • Savings magnitude is foremost determined by chosen primary energy and materials production. • Energy consumption and process losses can be upset by increased technology efficiency. • Material recovery accounts for significant shares of primary energy savings. • Direct waste-to-energy is highly efficient if cogeneration (CHP) is possible. - Abstract: Primary energy savings potential is used to compare five residual municipal solid waste treatment systems, including configurations with mechanical (MT) and mechanical–biological (MBT) pre-treatment, which produce waste-derived fuels (RDF and SRF), biogasmore » and/or recover additional materials for recycling, alongside a system based on conventional mass burn waste-to-energy and ash treatment. To examine the magnitude of potential savings we consider two energy efficiency levels (state-of-the-art and best available technology), the inclusion/exclusion of heat recovery (CHP vs. PP) and three different background end-use energy production systems (coal condensing electricity and natural gas heat, Nordic electricity mix and natural gas heat, and coal CHP energy quality allocation). The systems achieved net primary energy savings in a range between 34 and 140 MJ{sub primary}/100 MJ{sub input} {sub waste}, in the different scenario settings. The energy footprint of transportation needs, pre-treatment and reprocessing of recyclable materials was 3–9.5%, 1–18% and 1–8% respectively, relative to total energy savings. Mass combustion WtE achieved the highest savings in scenarios with CHP production, nonetheless, MBT-based systems had similarly high performance if SRF streams were co-combusted with coal. When RDF and SRF was only used in dedicated WtE plants, MBT-based systems totalled lower savings due to inherent system losses and additional energy costs. In scenarios without heat recovery, the biodrying MBS-based system achieved the highest savings, on the condition of SRF co-combustion. As a sensitivity scenario, alternative utilisation of SRF in cement kilns was modelled. It supported similar or higher net savings for all pre-treatment systems compared to mass combustion WtE, except when WtE CHP was possible in the first two background energy scenarios. Recovery of plastics for recycling before energy recovery increased net energy savings in most scenario variations, over those of full stream combustion. Sensitivity to assumptions regarding virgin plastic substitution was tested and was found to mostly favour plastic recovery.« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hoffman, Michael G.; Srivastava, Viraj; Wagner, Anne W.

The Pacific Northwest National Laboratory (PNNL) has launched a project funded by the Bonneville Power Association (BPA) to identify strategies for increasing industrial energy efficiency and reducing energy costs of Northwest Food Processors Association (NWFPA) plants through deployment of novel combinations and designs of variable-output combined heat and power (CHP) distributed generation (DG), combined cooling, heating and electric power (CCHP) DG and energy storage systems. Detailed evaluations and recommendations of CHP and CCHP DG systems will be performed for several Northwest (NW) food processing sites. The objective is to reduce the overall energy use intensity of NW food processors bymore » 25% by 2020 and by 50% by 2030, as well as reducing emissions and understanding potential congestion reduction impacts on the transmission system in the Pacific Northwest.« less

An efficient employer strategy for dealing with adverse selection in multiple-plan offerings: an MSA example.

PubMed

Pauly, M V; Herring, B J

2000-07-01

This paper outlines a feasible employee premium contribution policy, which would reduce the inefficiency associated with adverse selection when a limited coverage insurance policy is offered alongside a more generous policy. The "efficient premium contribution" is defined and is shown to lead to an efficient allocation across plans of persons who differ by risk, but it may also redistribute against higher risks. A simulation of the additional option of a catastrophic health plan (CHP) accompanied by a medical savings account (MSA) is presented. The efficiency gains from adding the MSA/catastrophic health insurance plan (CHP) option are positive but small, and the adverse consequences for high risks under an efficient employee premium are also small.

Development of Residential SOFC Cogeneration System

NASA Astrophysics Data System (ADS)

Ono, Takashi; Miyachi, Itaru; Suzuki, Minoru; Higaki, Katsuki

2011-06-01

Since 2001 Kyocera has been developing 1kW class Solid Oxide Fuel Cell (SOFC) for power generation system. We have developed a cell, stack, module and system. Since 2004, Kyocera and Osaka Gas Co., Ltd. have been developed SOFC residential co-generation system. From 2007, we took part in the "Demonstrative Research on Solid Oxide Fuel Cells" Project conducted by New Energy Foundation (NEF). Total 57 units of 0.7kW class SOFC cogeneration systems had been installed at residential houses. In spite of residential small power demand, the actual electric efficiency was about 40%(netAC,LHV), and high CO2 reduction performance was achieved by these systems. Hereafter, new joint development, Osaka Gas, Toyota Motors, Kyocera and Aisin Seiki, aims early commercialization of residential SOFC CHP system.

Five-year outcomes for frontline brentuximab vedotin with CHP for CD30-expressing peripheral T-cell lymphomas.

PubMed

Fanale, Michelle A; Horwitz, Steven M; Forero-Torres, Andres; Bartlett, Nancy L; Advani, Ranjana H; Pro, Barbara; Chen, Robert W; Davies, Andrew; Illidge, Tim; Uttarwar, Mayur; Lee, Shih-Yuan; Ren, Hong; Kennedy, Dana A; Shustov, Andrei R

2018-05-10

This phase 1 study evaluated frontline brentuximab vedotin in combination with cyclophosphamide, doxorubicin, and prednisone (BV+CHP; 6 cycles, then up to 10 cycles of brentuximab vedotin monotherapy) in 26 patients with CD30 + peripheral T-cell lymphoma, including 19 with systemic anaplastic large cell lymphoma. All patients (100%) achieved an objective response, with a complete remission (CR) rate of 92%; none received a consolidative stem cell transplant. After a median observation period of 59.6 months (range, 4.6-66.0) from first dose, neither the median progression-free survival (PFS) nor the median overall survival (OS) was reached. No progression or death was observed beyond 35 months. The estimated 5-year PFS and OS rates were 52% and 80%, respectively. Eighteen of 19 patients (95%) with treatment-emergent peripheral neuropathy (PN) reported resolution or improvement of symptoms. Thirteen patients (50%) remained in remission at the end of the study, with PFS ranging from 37.8+ to 66.0+ months. Eight of these 13 patients received the maximum 16 cycles of study treatment. These final results demonstrate durable remissions in 50% of patients treated with frontline BV+CHP, suggesting a potentially curative treatment option for some patients. This trial was registered at www.clinicaltrials.gov as #NCT01309789. © 2018 by The American Society of Hematology.

Integrating remediation and resource recovery: On the economic conditions of landfill mining.

PubMed

Frändegård, Per; Krook, Joakim; Svensson, Niclas

2015-08-01

This article analyzes the economic potential of integrating material separation and resource recovery into a landfill remediation project, and discusses the result and the largest impact factors. The analysis is done using a direct costs/revenues approach and the stochastic uncertainties are handled using Monte Carlo simulation. Two remediation scenarios are applied to a hypothetical landfill. One scenario includes only remediation, while the second scenario adds resource recovery to the remediation project. Moreover, the second scenario is divided into two cases, case A and B. In case A, the landfill tax needs to be paid for re-deposited material and the landfill holder does not own a combined heat and power plant (CHP), which leads to disposal costs in the form of gate fees. In case B, the landfill tax is waived on the re-deposited material and the landfill holder owns its own CHP. Results show that the remediation project in the first scenario costs about €23/ton. Adding resource recovery as in case A worsens the result to -€36/ton, while for case B the result improves to -€14/ton. This shows the importance of landfill tax and the access to a CHP. Other important factors for the result are the material composition in the landfill, the efficiency of the separation technology used, and the price of the saleable material. Copyright © 2015 Elsevier Ltd. All rights reserved.

Design and analysis of permanent magnet moving coil type generator used in a micro-CHP generation system

NASA Astrophysics Data System (ADS)

Oros Pop, Susana Teodora; Berinde, Ioan; Vadan, Ioan

2015-12-01

This paper presents the design and analysis of a permanent magnet moving coil type generator driven by a free piston Stirling engine. This assemble free piston Stirling engine - permanent magnet moving coil type generator will be used in a combined heat and power (CHP) system for producing heat and power in residential area. The design procedure for moving coil type linear generator starts from the rated power imposed and finally uses the Faraday law of induction. The magneto-static magnetic field generated by permanent magnets is analyzed by means of Reluctance method and Finite Element Method in order to evaluate the magnetic flux density in the air gap, which is a design data imposed in the design stage, and the results are compared.

Residential Central Air Conditioning and Heat Pump Installation – Workshop Outcomes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Goetzler, William; Zogg, Robert; Young, Jim

DOE's Building Technologies Office works with researchers and industry partners to develop and deploy technologies that can substantially reduce energy consumption in residential and commercial buildings. This report aims to advance BTO’s energy savings, emissions reduction, and other program goals by identifying research and development (R&D), demonstration and deployment, and other non-regulatory initiatives for improving the design and installation of residential central air conditioners (CAC) and central heat pumps (CHP). Improving the adoption of CAC/CHP design and installation best practices has significant potential to reduce equipment costs, improve indoor air quality and comfort, improve system performance, and most importantly, reducemore » household energy consumption and costs for heating and cooling by addressing a variety of common installation issues.« less

Research, Development and Demonstration of Micro-CHP Systems for Residential Applications - Phase I

DOE Office of Scientific and Technical Information (OSTI.GOV)

Robert A. Zogg

The objective of the Micro-CHP Phase I effort was to develop a conceptual design for a Micro-CHP system including: Defining market potential; Assessing proposed technology; Developing a proof-of-principle design; and Developing a commercialization strategy. TIAX LLC assembled a team to develop a Micro-CHP system that will provide electricity and heating. TIAX, the contractor and major cost-share provider, provided proven expertise in project management, prime-mover design and development, appliance development and commercialization, analysis of residential energy loads, technology assessment, and market analysis. Kohler Company, the manufacturing partner, is a highly regarded manufacturer of standby power systems and other residential products. Kohlermore » provides a compellingly strong brand, along with the capabilities in product development, design, manufacture, distribution, sales, support, service, and marketing that only a manufacturer of Kohler's status can provide. GAMA, an association of appliance and equipment manufacturers, provided a critical understanding of appliance commercialization issues, including regulatory requirements, large-scale market acceptance issues, and commercialization strategies. The Propane Education & Research Council, a cost-share partner, provided cost share and aided in ensuring the fuel flexibility of the conceptual design. Micro-CHP systems being commercialized in Europe and Japan are generally designed to follow the household thermal load, and generate electricity opportunistically. In many cases, any excess electricity can be sold back to the grid (net metering). These products, however, are unlikely to meet the demands of the U.S. market. First, these products generally cannot provide emergency power when grid power is lost--a critical feature to market success in the U.S. Even those that can may have insufficient electric generation capacities to meet emergency needs for many U.S. homes. Second, the extent to which net metering will be available in the U.S. is unclear. Third, these products are typically not designed for use in households having forced hot-air heating, which is the dominant heating system in the U.S. The U.S. market will also require a major manufacturer that has the reputation and brand recognition, low-cost manufacturing capability, distribution, sales, and service infrastructure, and marketing power to achieve significant market size with a previously unknown and unproven product. History has proven time and time again that small-to-medium-size manufacturers do not have the resources and capabilities to achieve significant markets with such products. During the Phase I effort, the Team developed a conceptual design for a Micro-CHP system that addresses key DOE and U.S. market needs: (1) Provides emergency power adequate for critical household loads, with none of the key drawbacks associated with typical, low-cost emergency generators, such as liquid fuel storage, inability to power ''hard-wired'' loads, need to run temporary extension cords for plug loads, manual set up required, susceptibility to overload, and risk of failure due to lack of maintenance and infrequent operation; (2) Requires no special skills to install--plumbers, electricians and HVAC technicians will typically have all necessary skills; (3) Can be used with the major residential fuels in the U.S., including natural gas and propane, and can be easily adapted to fuel oil as well as emerging fuels as they become available; and (4) Significantly reduces household energy consumption and energy costs.« less

Antimicrobial Activity and Physicochemical Properties of Calcium Hydroxide Pastes Used as Intracanal Medication.

PubMed

Zancan, Rafaela Fernandes; Vivan, Rodrigo Ricci; Milanda Lopes, Marcelo Ribeiro; Weckwerth, Paulo Henrique; de Andrade, Flaviana Bombarda; Ponce, José Burgos; Duarte, Marco Antonio Hungaro

2016-12-01

The aim of the present study was to evaluate the pH, calcium release, solubility, and antimicrobial action against biofilms of calcium hydroxide + saline solution, Calen (SS White Artigos Dentários Ltd, Rio de Janeiro, Brazil) (CH/P), Calen camphorated paramonochlorophenol (CMCP) (CH/CMPC), and calcium hydroxide + chlorhexidine (CH/CHX) pastes. The pH of the pastes was determined with a calibrated pH meter placed in direct contact with each paste. The root canals of acrylic teeth (N = 10) were filled with the previously mentioned intracanal dressings and immersed in ultrapure water to measure hydroxyl (pH meter) and calcium ion release (atomic absorption spectrophotometer) at time intervals of 3, 7, 15, and 30 days. To assess solubility, the root canals of acrylic teeth (N = 10) were filled with the previously mentioned pastes and scanned by micro-computed tomographic imaging before (initial) and after 7, 15, and 30 days of immersion in ultrapure water. The solubility of each specimen was the difference between the initial and final volume scanning. For antimicrobial analysis, monospecies and dual-species biofilms were in vitro induced on dentin blocks (N = 20). Afterward, they were treated with the pastes for 7 days. Live/dead dye and a confocal microscope were used to measure the percentage of living cells. Data were statistically compared (P < .05). The highest OH - ion release values were found in 3 and 30 days. Ca 2+ releases were greater in CH/CMCP. CH/P and CH/CMCP showed a higher percentage of volume loss values. CH/CHX presented the greatest antimicrobial action. CH/P and CH/CMPC showed higher solubility values in the period analyzed. Seven days of contact may be insufficient for calcium hydroxide + saline solution, CH/P, and CH/CMCP pastes to kill bacterial cells in the biofilms studied. Chlorhexidine added to CH favored greater effectiveness against the previously mentioned bacterial biofilms. Copyright © 2016 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.

Global warming potential of material fractions occurring in source-separated organic household waste treated by anaerobic digestion or incineration under different framework conditions.

PubMed

Naroznova, Irina; Møller, Jacob; Scheutz, Charlotte

2016-12-01

This study compared the environmental profiles of anaerobic digestion (AD) and incineration, in relation to global warming potential (GWP), for treating individual material fractions that may occur in source-separated organic household waste (SSOHW). Different framework conditions representative for the European Union member countries were considered. For AD, biogas utilisation with a biogas engine was considered and two potential situations investigated - biogas combustion with (1) combined heat and power production (CHP) and (2) electricity production only. For incineration, four technology options currently available in Europe were covered: (1) an average incinerator with CHP production, (2) an average incinerator with mainly electricity production, (3) an average incinerator with mainly heat production and (4) a state-of-the art incinerator with CHP working at high energy recovery efficiencies. The study was performed using a life cycle assessment in its consequential approach. Furthermore, the role of waste-sorting guidelines (defined by the material fractions allowed for SSOHW) in relation to GWP of treating overall SSOHW with AD was investigated. A case-study of treating 1tonne of SSOHW under framework conditions in Denmark was conducted. Under the given assumptions, vegetable food waste was the only material fraction which was always better for AD compared to incineration. For animal food waste, kitchen tissue, vegetation waste and dirty paper, AD utilisation was better unless it was compared to a highly efficient incinerator. Material fractions such as moulded fibres and dirty cardboard were attractive for AD, albeit only when AD with CHP and incineration with mainly heat production were compared. Animal straw, in contrast, was always better to incinerate. Considering the total amounts of individual material fractions in waste generated within households in Denmark, food waste (both animal and vegetable derived) and kitchen tissue are the main material fractions allowing GWP mitigation with AD when it is compared to incineration. The inclusion of other material fractions in SSOHW sorting guidelines may be considered of less importance. Copyright © 2016 Elsevier Ltd. All rights reserved.

Energy implications of mechanical and mechanical-biological treatment compared to direct waste-to-energy.

PubMed

Cimpan, Ciprian; Wenzel, Henrik

2013-07-01

Primary energy savings potential is used to compare five residual municipal solid waste treatment systems, including configurations with mechanical (MT) and mechanical-biological (MBT) pre-treatment, which produce waste-derived fuels (RDF and SRF), biogas and/or recover additional materials for recycling, alongside a system based on conventional mass burn waste-to-energy and ash treatment. To examine the magnitude of potential savings we consider two energy efficiency levels (state-of-the-art and best available technology), the inclusion/exclusion of heat recovery (CHP vs. PP) and three different background end-use energy production systems (coal condensing electricity and natural gas heat, Nordic electricity mix and natural gas heat, and coal CHP energy quality allocation). The systems achieved net primary energy savings in a range between 34 and 140 MJprimary/100 MJinput waste, in the different scenario settings. The energy footprint of transportation needs, pre-treatment and reprocessing of recyclable materials was 3-9.5%, 1-18% and 1-8% respectively, relative to total energy savings. Mass combustion WtE achieved the highest savings in scenarios with CHP production, nonetheless, MBT-based systems had similarly high performance if SRF streams were co-combusted with coal. When RDF and SRF was only used in dedicated WtE plants, MBT-based systems totalled lower savings due to inherent system losses and additional energy costs. In scenarios without heat recovery, the biodrying MBS-based system achieved the highest savings, on the condition of SRF co-combustion. As a sensitivity scenario, alternative utilisation of SRF in cement kilns was modelled. It supported similar or higher net savings for all pre-treatment systems compared to mass combustion WtE, except when WtE CHP was possible in the first two background energy scenarios. Recovery of plastics for recycling before energy recovery increased net energy savings in most scenario variations, over those of full stream combustion. Sensitivity to assumptions regarding virgin plastic substitution was tested and was found to mostly favour plastic recovery. Copyright © 2013 Elsevier Ltd. All rights reserved.

Distributed Energy Resources On-Site Optimization for Commercial Buildings with Electric and Thermal Storage Technologies

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lacommare, Kristina S H; Stadler, Michael; Aki, Hirohisa

The addition of storage technologies such as flow batteries, conventional batteries, and heat storage can improve the economic as well as environmental attractiveness of on-site generation (e.g., PV, fuel cells, reciprocating engines or microturbines operating with or without CHP) and contribute to enhanced demand response. In order to examine the impact of storage technologies on demand response and carbon emissions, a microgrid's distributed energy resources (DER) adoption problem is formulated as a mixed-integer linear program that has the minimization of annual energy costs as its objective function. By implementing this approach in the General Algebraic Modeling System (GAMS), the problemmore » is solved for a given test year at representative customer sites, such as schools and nursing homes, to obtain not only the level of technology investment, but also the optimal hourly operating schedules. This paper focuses on analysis of storage technologies in DER optimization on a building level, with example applications for commercial buildings. Preliminary analysis indicates that storage technologies respond effectively to time-varying electricity prices, i.e., by charging batteries during periods of low electricity prices and discharging them during peak hours. The results also indicate that storage technologies significantly alter the residual load profile, which can contribute to lower carbon emissions depending on the test site, its load profile, and its adopted DER technologies.« less

Energy from Landfill Gas as an Example of Circular Economy

NASA Astrophysics Data System (ADS)

Ciuła, Józef; Gaska, Krzysztof; Generowicz, Agnieszka; Hajduga, Gabriela

2018-02-01

Landfill biogas becomes an important factor in elimination of fossil fuels as a result of fast- growing use of renewable energy sources. The article presents an analysis of operation of the plant where landfill biogas was utilized for energy production. The average annually (gross) productions of electric energy and heat at the plant were 1217 MWh and 1,789 MW, respectively. The average calorific value of biogas was 17 MJ/m3, which corresponds to 4,8 kW/m3. According to the measurements and actual readings acquired during operation of a cogeneration unit, it can be stated that the CHP system has been working within its average operation limits and still has some power reserves to utilize. Therefore, the authors concluded that a landfill can be operated both as a producer and a supplier of prosumer energy.

Strengthening Critical Infrastructure: Combined Heat and Power at Wastewater Treatment Facilities (Webinar) – November 15, 2011

EPA Pesticide Factsheets

This webinar provides information about CHP at wastewater treatment facilities (WWTFs), including advantages and challenges, financial incentives and funding programs, and technical and economic potential.

Then and now: a revision of the city health profile of the city of Pécs, Hungary.

PubMed

Girán, János; Kiss, István; De Blasio, Antonio

2016-03-01

The City of Pécs, a founding member, has participated in the World Health Organization European Healthy Cities Network (WHO-EHCN) since 1986. Each WHO-EHCN city prepares a city health profile (CHP) through which it supports local health-related activities. The first CHP of Pécs was carried out in 1996. The aim of more recent research has been to implement a comprehensive review of the first CHP and to make a comparative analysis between the results of the former and the updated CHPs. The data were received from different databases and a telephone survey. The review showed improvement in those areas that can be influenced through the measures of the city authorities. The survey showed that both the ratio of smokers and the amount of cigarettes smoked had decreased so that the ratio of regular smokers became the lowest among the youngest age group. The number of alcohol consumers increased, while the amount of alcohol consumed dropped slightly, meaning that alcohol consumption per capita decreased overall. The comparative analysis highlighted unhealthy diets, insufficient sleep duration and physical inactivity becoming significant health risk factors. To avoid a 'reinventing the wheel' situation, it would be worth comparing the results of health and lifestyle surveys of other WHO-EHCN cities and eventually jointly devise the best solutions. © The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Three novel NY-ESO-1 epitopes bound to DRB1*0803, DQB1*0401 and DRB1*0901 recognized by CD4 T cells from CHP-NY-ESO-1-vaccinated patients.

PubMed

Mizote, Yu; Taniguchi, Taku; Tanaka, Kei; Isobe, Midori; Wada, Hisashi; Saika, Takashi; Kita, Shoichi; Koide, Yukari; Uenaka, Akiko; Nakayama, Eiichi

2010-07-19

Three novel NY-ESO-1 CD4 T cell epitopes were identified using PBMC obtained from patients who were vaccinated with a complex of cholesterol-bearing hydrophobized pullulan (CHP) and NY-ESO-1 protein (CHP-NY-ESO-1). The restriction molecules were determined by antibody blocking and using various EBV-B cells with different HLA alleles as APC to present peptides to CD4 T cells. The minimal epitope peptides were determined using various N- and C-termini truncated peptides deduced from 18-mer overlapping peptides originally identified for recognition. Those epitopes were DRB1*0901-restricted NY-ESO-1 87-100, DQB1*0401-restricted NY-ESO-1 95-107 and DRB1*0803-restricted NY-ESO-1 124-134. CD4 T cells used to determine those epitope peptides recognized EBV-B cells or DC that were treated with recombinant NY-ESO-1 protein or NY-ESO-1-expressing tumor cell lysate, suggesting that the epitope peptides are naturally processed. These CD4 T cells showed a cytokine profile with Th1 characteristics. Furthermore, NY-ESO-1 87-100 peptide/HLA-DRB1*0901 tetramer staining was observed. Multiple Th1-type CD4 T cell responses are beneficial for inducing effective anti-tumor responses after NY-ESO-1 protein vaccination. (c) 2010 Elsevier Ltd. All rights reserved.

Effects of Particle Hydrophobicity, Surface Charge, Media pH Value and Complexation with Human Serum Albumin on Drug Release Behavior of Mitoxantrone-Loaded Pullulan Nanoparticles

PubMed Central

Tao, Xiaojun; Jin, Shu; Wu, Dehong; Ling, Kai; Yuan, Liming; Lin, Pingfa; Xie, Yongchao; Yang, Xiaoping

2015-01-01

We prepared two types of cholesterol hydrophobically modified pullulan nanoparticles (CHP) and carboxyethyl hydrophobically modified pullulan nanoparticles (CHCP) substituted with various degrees of cholesterol, including 3.11, 6.03, 6.91 and 3.46 per polymer, and named CHP−3.11, CHP−6.03, CHP−6.91 and CHCP−3.46. Dynamic laser light scattering (DLS) showed that the pullulan nanoparticles were 80–120 nm depending on the degree of cholesterol substitution. The mean size of CHCP nanoparticles was about 160 nm, with zeta potential −19.9 mV, larger than CHP because of the carboxyethyl group. A greater degree of cholesterol substitution conferred greater nanoparticle hydrophobicity. Drug-loading efficiency depended on nanoparticle hydrophobicity, that is, nanoparticles with the greatest degree of cholesterol substitution (6.91) showed the most drug encapsulation efficiency (90.2%). The amount of drug loading increased and that of drug release decreased with enhanced nanoparticle hydrophobicity. Nanoparticle surface-negative charge disturbed the amount of drug loading and drug release, for an opposite effect relative to nanoparticle hydrophobicity. The drug release in pullulan nanoparticles was higher pH 4.0 than pH 6.8 media. However, the changed drug release amount was not larger for negative-surface nanoparticles than CHP nanoparticles in the acid release media. Drug release of pullulan nanoparticles was further slowed with human serum albumin complexation and was little affected by nanoparticle hydrophobicity and surface negative charge. PMID:28344259

Energy and Environment Guide to Action - Chapter 7: Electric Utility Policies

EPA Pesticide Factsheets

Focuses on the authorites that state legislatures have granted to PUCs to regulate electricity and reliability, as these authorities directly affect utilities' and customers' investments in energy efficiency, renewable energy, and CHP.

Energy and Environment Guide to Action - Chapter 7.4: Customer Rates and Data Access

EPA Pesticide Factsheets

Provides recommendations for designing, implementing, and evaluating utility rates and providing data access to support energy efficiency, CHP, and clean energy goals. State examples are included for reference.

Energy and Environment Guide to Action- Executive Summary

EPA Pesticide Factsheets

Summarizes the key messages and purpose of the Energy and Environment Guide to Action, which describes the latest best practices and opportunities that states are using to invest in energy efficiency, renewable energy, and CHP.

Mitochondrial DNA Variant in COX1 Subunit Significantly Alters Energy Metabolism of Geographically Divergent Wild Isolates in Caenorhabditis elegans

PubMed Central

Dingley, Stephen D.; Polyak, Erzsebet; Ostrovsky, Julian; Srinivasan, Satish; Lee, Icksoo; Rosenfeld, Amy B.; Tsukikawa, Mai; Xiao, Rui; Selak, Mary A.; Coon, Joshua J.; Hebert, Alexander S.; Grimsrud, Paul A.; Kwon, Young Joon; Pagliarini, David J.; Gai, Xiaowu; Schurr, Theodore G.; Hüttemann, Maik; Nakamaru-Ogiso, Eiko; Falk, Marni J.

2014-01-01

Mitochondrial DNA (mtDNA) sequence variation can influence the penetrance of complex diseases and climatic adaptation. While studies in geographically defined human populations suggest that mtDNA mutations become fixed when they have conferred metabolic capabilities optimally suited for a specific environment, it has been challenging to definitively assign adaptive functions to specific mtDNA sequence variants in mammals. We investigated whether mtDNA genome variation functionally influences Caenorhabditis elegans wild isolates of distinct mtDNA lineages and geographic origins. We found that, relative to N2 (England) wild-type nematodes, CB4856 wild isolates from a warmer native climate (Hawaii) had a unique p.A12S amino acid substitution in the mtDNA-encoded COX1 core catalytic subunit of mitochondrial complex IV (CIV). Relative to N2, CB4856 worms grown at 20 °C had significantly increased CIV enzyme activity, mitochondrial matrix oxidant burden, and sensitivity to oxidative stress but had significantly reduced lifespan and mitochondrial membrane potential. Interestingly, mitochondrial membrane potential was significantly increased in CB4856 grown at its native temperature of 25 °C. A transmitochondrial cybrid worm strain, chpIR (M, CB4856 > N2), was bred as homoplasmic for the CB4856 mtDNA genome in the N2 nuclear background. The cybrid strain also displayed significantly increased CIV activity, demonstrating that this difference results from the mtDNA-encoded p.A12S variant. However, chpIR (M, CB4856 > N2) worms had significantly reduced median and maximal lifespan relative to CB4856, which may relate to their nuclear– mtDNA genome mismatch. Overall, these data suggest that C. elegans wild isolates of varying geographic origins may adapt to environmental challenges through mtDNA variation to modulate critical aspects of mitochondrial energy metabolism. PMID:24534730

Biomass thermochemical gasification: Experimental studies and modeling

NASA Astrophysics Data System (ADS)

Kumar, Ajay

The overall goals of this research were to study the biomass thermochemical gasification using experimental and modeling techniques, and to evaluate the cost of industrial gas production and combined heat and power generation. This dissertation includes an extensive review of progresses in biomass thermochemical gasification. Product gases from biomass gasification can be converted to biopower, biofuels and chemicals. However, for its viable commercial applications, the study summarizes the technical challenges in the gasification and downstream processing of product gas. Corn stover and dried distillers grains with solubles (DDGS), a non-fermentable byproduct of ethanol production, were used as the biomass feedstocks. One of the objectives was to determine selected physical and chemical properties of corn stover related to thermochemical conversion. The parameters of the reaction kinetics for weight loss were obtained. The next objective was to investigate the effects of temperature, steam to biomass ratio and equivalence ratio on gas composition and efficiencies. DDGS gasification was performed on a lab-scale fluidized-bed gasifier with steam and air as fluidizing and oxidizing agents. Increasing the temperature resulted in increases in hydrogen and methane contents and efficiencies. A model was developed to simulate the performance of a lab-scale gasifier using Aspen Plus(TM) software. Mass balance, energy balance and minimization of Gibbs free energy were applied for the gasification to determine the product gas composition. The final objective was to optimize the process by maximizing the net energy efficiency, and to estimate the cost of industrial gas, and combined heat and power (CHP) at a biomass feedrate of 2000 kg/h. The selling price of gas was estimated to be 11.49/GJ for corn stover, and 13.08/GJ for DDGS. For CHP generation, the electrical and net efficiencies were 37 and 86%, respectively for corn stover, and 34 and 78%, respectively for DDGS. For corn stover, the selling price of electricity was 0.1351/kWh. For DDGS, the selling price of electricity was 0.1287/kWh.

Industrial Facility Combustion Energy Use

DOE Data Explorer

McMillan, Colin

2016-08-01

Facility-level industrial combustion energy use is calculated from greenhouse gas emissions data reported by large emitters (>25,000 metric tons CO2e per year) under the U.S. EPA's Greenhouse Gas Reporting Program (GHGRP, https://www.epa.gov/ghgreporting). The calculation applies EPA default emissions factors to reported fuel use by fuel type. Additional facility information is included with calculated combustion energy values, such as industry type (six-digit NAICS code), location (lat, long, zip code, county, and state), combustion unit type, and combustion unit name. Further identification of combustion energy use is provided by calculating energy end use (e.g., conventional boiler use, co-generation/CHP use, process heating, other facility support) by manufacturing NAICS code. Manufacturing facilities are matched by their NAICS code and reported fuel type with the proportion of combustion fuel energy for each end use category identified in the 2010 Energy Information Administration Manufacturing Energy Consumption Survey (MECS, http://www.eia.gov/consumption/manufacturing/data/2010/). MECS data are adjusted to account for data that were withheld or whose end use was unspecified following the procedure described in Fox, Don B., Daniel Sutter, and Jefferson W. Tester. 2011. The Thermal Spectrum of Low-Temperature Energy Use in the United States, NY: Cornell Energy Institute.

Energy and Environment Guide to Action - Chapter 7.0: Electric Utility Policies

EPA Pesticide Factsheets

Focuses on the authorites that state legislatures have granted to PUCs to regulate electricity and reliability, as these authorities directly affect utilities' and customers' investments in energy efficiency, renewable energy, and CHP.

Use of videotape in HOV lane surveillance and enforcement

DOT National Transportation Integrated Search

1990-03-01

Enforcement of Californias HOV lanes currently requires substantial commitments of California Highway Patrol (CHP) personnel and equipment. Personnel costs for enforcing the states ten mainline HOV lanes alone will exceed $400,000 in 1990. HOV ...

Combined Heat and Power

EPA Pesticide Factsheets

CHP is on-site electricity generation that captures the heat that would otherwise be wasted to provide useful thermal energy such as steam or hot water than can be used for space heating, cooling, domestic hot water and industrial processes.

Molecular level detection and localization of mechanical damage in collagen enabled by collagen hybridizing peptides.

PubMed

Zitnay, Jared L; Li, Yang; Qin, Zhao; San, Boi Hoa; Depalle, Baptiste; Reese, Shawn P; Buehler, Markus J; Yu, S Michael; Weiss, Jeffrey A

2017-03-22

Mechanical injury to connective tissue causes changes in collagen structure and material behaviour, but the role and mechanisms of molecular damage have not been established. In the case of mechanical subfailure damage, no apparent macroscale damage can be detected, yet this damage initiates and potentiates in pathological processes. Here, we utilize collagen hybridizing peptide (CHP), which binds unfolded collagen by triple helix formation, to detect molecular level subfailure damage to collagen in mechanically stretched rat tail tendon fascicle. Our results directly reveal that collagen triple helix unfolding occurs during tensile loading of collagenous tissues and thus is an important damage mechanism. Steered molecular dynamics simulations suggest that a likely mechanism for triple helix unfolding is intermolecular shearing of collagen α-chains. Our results elucidate a probable molecular failure mechanism associated with subfailure injuries, and demonstrate the potential of CHP targeting for diagnosis, treatment and monitoring of tissue disease and injury.

Haemangiopericytoma: histological spectrum, immunohistochemical characterization and prognosis.

PubMed

Mazzei, Maurizio; Millanta, Francesca; Citi, Simona; Lorenzi, Davide; Poli, Alessandro

2002-02-01

Canine haemangiopericytoma (CHP) is a vascular neoplasm thought to be derived from pericytes. The histological pattern and immunohistochemical profile were studied in 31 CHPs. Twenty-three subjects were followed for 2 years to evaluate the correlation among tumour location, histotype, immunostaining and outcome of the disease. Of the 31 CHPs examined, 20 exhibited a perivascular whorled pattern, 8 were storiform and 3 were epithelioid. All tumours were positive for vimentin and negative for cytokeratin, factor VIII-related antigen, glial fibrillary acidic protein and S-100 protein. Seventeen CHPs were positive for actin and nine co-expressed desmin. Six CHPs were also positive for CD34 antigen. The panel of immunohistochemical markers used confirmed the vascular lineage of CHP and aided in the exclusion of other mesenchymal tumours. Of the 23 dogs submitted to follow-up, 6 had recurrence or metastases of the primary tumour. The epithelioid pattern or a noncutaneous location were associated with a poorer prognosis.

Municipal Development of Anaerobic Digestion/ Combined Heat and Power in Massachusetts

NASA Astrophysics Data System (ADS)

Pike, Brenda

With a commercial food waste ban going into effect in Massachusetts in October 2014, businesses, institutions, and municipalities are considering alternatives to landfills and incinerators for organic waste. Anaerobic digestion is one such alternative. Similar to composting, but in an environment devoid of oxygen, anaerobic digestion produces byproducts such as methane (which can be burned for heat or electricity) and liquid or solid digestate (which can be used as fertilizer, cattle bedding, and more). Thus, disposal of food waste and other organic materials can become a source of revenue rather than just an expense. Municipalities interested in developing anaerobic digestion/combined heat and power (AD/CHP) facilities have the benefit of desirable options for sites, such as landfill gas facilities and wastewater treatment plants, and potential feedstocks in source-separated residential or municipal food waste or wastewater. This thesis examines the opportunities and challenges for municipal development of AD/CHP facilities in Massachusetts.

Liquid exfoliation of solvent-stabilized few-layer black phosphorus for applications beyond electronics

PubMed Central

Hanlon, Damien; Backes, Claudia; Doherty, Evie; Cucinotta, Clotilde S.; Berner, Nina C.; Boland, Conor; Lee, Kangho; Harvey, Andrew; Lynch, Peter; Gholamvand, Zahra; Zhang, Saifeng; Wang, Kangpeng; Moynihan, Glenn; Pokle, Anuj; Ramasse, Quentin M.; McEvoy, Niall; Blau, Werner J.; Wang, Jun; Abellan, Gonzalo; Hauke, Frank; Hirsch, Andreas; Sanvito, Stefano; O'Regan, David D.; Duesberg, Georg S.; Nicolosi, Valeria; Coleman, Jonathan N.

2015-01-01

Few-layer black phosphorus (BP) is a new two-dimensional material which is of great interest for applications, mainly in electronics. However, its lack of environmental stability severely limits its synthesis and processing. Here we demonstrate that high-quality, few-layer BP nanosheets, with controllable size and observable photoluminescence, can be produced in large quantities by liquid phase exfoliation under ambient conditions in solvents such as N-cyclohexyl-2-pyrrolidone (CHP). Nanosheets are surprisingly stable in CHP, probably due to the solvation shell protecting the nanosheets from reacting with water or oxygen. Experiments, supported by simulations, show reactions to occur only at the nanosheet edge, with the rate and extent of the reaction dependent on the water/oxygen content. We demonstrate that liquid-exfoliated BP nanosheets are potentially useful in a range of applications from ultrafast saturable absorbers to gas sensors to fillers for composite reinforcement. PMID:26469634

Nonsurgical periodontal-therapy improves glycosylated hemoglobin levels in pre-diabetic patients with chronic periodontitis

PubMed Central

Joseph, Rosamma; Sasikumar, Meera; Mammen, Jerry; Joseraj, M G; Radhakrishnan, Chandni

2017-01-01

AIM To evaluate the effect of nonsurgical periodontal therapy on glycosylated haemoglobin levels in pre-diabetic patients with chronic periodontitis (CHP). METHODS Sixty pre-diabetic patients with CHP were selected and equally allocated to case and control group. All subjects were evaluated at base line for periodontal parameters (plaque index, oral hygiene index, modified gingival index, probing pocket depth, clinical attachment level) and systemic parameters [glycosylated hemoglobin (HbA1c), fasting lipid profile, and fasting blood glucose]. The case group received non-surgical periodontal therapy. Subjects were re-evaluated for periodontal and systemic parameters after three months. RESULTS Both groups were comparable at baseline. Three months after non surgical periodontal therapy (NSPT), there was significant improvement in periodontal parameters in case group. The mean difference in systemic parameters like HbA1c and fasting plasma glucose from baseline to fourth month for case group was 0.22 ± 0.11 and 3.90 ± 8.48 respectively and control group was -0.056 ± 0.10 and -1.66 ± 6.04 respectively, which was significant between case and control group (P < 0.05). In the case group there was a significant decrease in HbA1c from baseline to three months following NSPT (P < 0.05). CONCLUSION This study showed that periodontal inflammation could affect the glycemic control in otherwise systemically healthy individuals. Periodontal therapy improved periodontal health status and decreased glycosylated haemoglobin levels, thus reducing the probability of occurrence of inflammation induced prediabetes in patients with CHP. PMID:28572882

Protective Effect of Selenium-Based Medicines on Toxicity of Three Common Organophosphorus Compounds in Human Erythrocytes In Vitro

PubMed Central

Mostafalou, Sara; Navaei-Nigjeh, Mona; Baeeri, Maryam; Mohammadirad, Azadeh; Abdollahi, Mohammad

2016-01-01

Objective Organophosphorus (OP) compounds are used to control pests, however they can reach the food chain and enter the human body causing serious health problems by means of acetylcholinesterase (AChE) inhibition and oxidative stress (OS). Among the OPs, chlorpyrifos (CHP), malathion (MAL), and diazinon (DIA) are commonly used for commercial extermination purposes, in addition to veterinary practices, domestic, agricul- ture and public health applications. Two new recently registered medicines that contain selenium and other antioxidants, IMOD and angipars (ANG), have shown beneficial ef- fects for OS related disorders. This study examines the effect of selenium-based medi- cines on toxicity of three common OP compounds in erythrocytes. Materials and Methods In the present experimental study, we determined the ef- ficacy of IMOD and ANG on OS induced by three mentioned OP pesticides in human erythrocytes in vitro. After dose-response studies, AChE, lipid peroxidation (LPO), total antioxidant power (TAP) and total thiol molecules (TTM) were measured in eryth- rocytes after exposure to OPs alone and in combined treatment with IMOD or ANG. Results AChE activity, TAP and TTM reduced in erythrocytes exposed to CHP, MAL and DIA while they were restored in the presence of ANG and IMOD. ANG and IMOD reduced the OPs-induced elevation of LPO. Conclusion The present study shows the positive effects of IMOD and ANG in re- duction of OS and restoration of AChE inhibition induced by CHP, MAL and DIA in erythrocytes in vitro. PMID:26862533

Production and characterization of films based on blends of chitosan from blue crab (Callinectes sapidus) waste and pectin from Orange (Citrus sinensis Osbeck) peel.

PubMed

Baron, Ricardo Duran; Pérez, Latife Lúquez; Salcedo, Jesús Mejía; Córdoba, Luis Pérez; Sobral, Paulo José do Amaral

2017-05-01

The objective of this study was to develop and characterize films based on blends of chitosan and pectin, produced in laboratory scale, from industrial wastes. The chitosan was obtained by termoalcaline deacetylation of chitin, extracted from blue crab (Callinectes sapidus) waste and characterized according to degree of deacetylation (DD) and viscosimetric molecular weight (Mw); and pectin was extracted by conventional heating, from orange (Citrus sinensis Osbeck) peel and characterized according to degree of esterification (DE) and molecular weight (Mw). The Ch:P based films were prepared by the casting method in different Ch:P ratios [0: 100, 25:75, 50:50, 75:25 and 100:0], and compared to two controls [0:100 and 100:0], of commercial pectin and chitosan. Glycerol was used as a plasticizer at concentrations of 0.2g/g macromolecules. The addition of high concentrations of pectin in the formulations resulted in films with high solubility and an increase in moisture. No significant difference (P>0.05) in the degree of swelling (DS) and water vapor permeability (WVP) of the films was observed. Ch:P blend films were less stiff and therefore more elastic and flexible than films based on only one biopolymer. The control films presented better results in terms of color, being brighter and less opaque than other film formulations. These data suggest that chitosan or pectin obtained from agro-industrial waste is a potential matrix to produce biodegradable films for future food applications. Copyright © 2017 Elsevier B.V. All rights reserved.

Increased systemic elastase and C-reactive protein in aggressive periodontitis (CLOI-D-00160R2).

PubMed

Wohlfeil, Martin; Scharf, Susanne; Siegelin, Yasemin; Schacher, Beate; Oremek, Gerhard M; Sauer-Eppel, Hildegund; Schubert, Ralf; Eickholz, Peter

2012-08-01

The inflammatory mediators, serum elastase and C-reactive protein (CRP), are associated with an increased risk for coronary heart disease. Thus, the aim of this study is to compare systemic inflammatory mediators in periodontally healthy controls (C), patients with untreated aggressive (AgP) and chronic (ChP) periodontitis. C [periodontal pocket probing depth (PPD)  <3.6 or <5 mm without bleeding (BOP), BOP < 10%], ChP (PDD ≥ 3.6 mm and probing attachment loss ≥5 mm at >30% of sites; age >35 years), and AgP (clinically healthy; PDD ≥ 3.6 mm at >30% of sites, bone loss ≥50% at ≥2 teeth; age ≤35 years) were examined clinically, and the body mass index was assessed. Blood was sampled for assessment of serum levels of elastase, CRP, lipopolysaccharide binding protein (LBP), interleukin (IL) 6, 8, and leukocyte counts. Thirty C, 31 ChP, and 29 AgP were analyzed. Elastase, CRP, LBP, and IL-6 levels were elevated in AgP compared to C (p < 0.013), whereas leukocyte counts and IL-8 were similar. Multiple regression analysis identified AgP (p < 0.001) and education level (p < 0.001) to explain 47% of the variation of elastase. AgP (p = 0.003), African origin (p = 0.006), female sex (p = 0.002), and BMI (p < 0.001) explained 39% of the variation of CRP. Serum elastase and CRP are significantly elevated in AgP compared to C. AgP patients exhibit a stronger systemic inflammatory burden than C patients.

Air quality impacts of projections of natural gas-fired distributed generation

NASA Astrophysics Data System (ADS)

Horne, Jeremy R.; Carreras-Sospedra, Marc; Dabdub, Donald; Lemar, Paul; Nopmongcol, Uarporn; Shah, Tejas; Yarwood, Greg; Young, David; Shaw, Stephanie L.; Knipping, Eladio M.

2017-11-01

This study assesses the potential impacts on emissions and air quality from the increased adoption of natural gas-fired distributed generation of electricity (DG), including displacement of power from central power generation, in the contiguous United States. The study includes four major tasks: (1) modeling of distributed generation market penetration; (2) modeling of central power generation systems; (3) modeling of spatially and temporally resolved emissions; and (4) photochemical grid modeling to evaluate the potential air quality impacts of increased DG penetration, which includes both power-only DG and combined heat and power (CHP) units, for 2030. Low and high DG penetration scenarios estimate the largest penetration of future DG units in three regions - New England, New York, and California. Projections of DG penetration in the contiguous United States estimate 6.3 GW and 24 GW of market adoption in 2030 for the low DG penetration and high DG penetration scenarios, respectively. High DG penetration (all of which is natural gas-fired) serves to offset 8 GW of new natural gas combined cycle (NGCC) units, and 19 GW of solar photovoltaic (PV) installations by 2030. In all scenarios, air quality in the central United States and the northwest remains unaffected as there is little to no DG penetration in those states. California and several states in the northeast are the most impacted by emissions from DG units. Peak increases in maximum daily 8-h average ozone concentrations exceed 5 ppb, which may impede attainment of ambient air quality standards. Overall, air quality impacts from DG vary greatly based on meteorological conditions, proximity to emissions sources, the number and type of DG installations, and the emissions factors used for DG units.

Energy and Environment Guide to Action - Chapter 6: Policy Considerations for Combined Heat and Power

EPA Pesticide Factsheets

CHP, also known as cogeneration, is the simultaneous production of electricity and heat from a single fuel source. Read more about recommendations for designing, implementing, and evaluating combined heat and power.

Estimation of marginal costs at existing waste treatment facilities.

PubMed

Martinez-Sanchez, Veronica; Hulgaard, Tore; Hindsgaul, Claus; Riber, Christian; Kamuk, Bettina; Astrup, Thomas F

2016-04-01

This investigation aims at providing an improved basis for assessing economic consequences of alternative Solid Waste Management (SWM) strategies for existing waste facilities. A bottom-up methodology was developed to determine marginal costs in existing facilities due to changes in the SWM system, based on the determination of average costs in such waste facilities as function of key facility and waste compositional parameters. The applicability of the method was demonstrated through a case study including two existing Waste-to-Energy (WtE) facilities, one with co-generation of heat and power (CHP) and another with only power generation (Power), affected by diversion strategies of five waste fractions (fibres, plastic, metals, organics and glass), named "target fractions". The study assumed three possible responses to waste diversion in the WtE facilities: (i) biomass was added to maintain a constant thermal load, (ii) Refused-Derived-Fuel (RDF) was included to maintain a constant thermal load, or (iii) no reaction occurred resulting in a reduced waste throughput without full utilization of the facility capacity. Results demonstrated that marginal costs of diversion from WtE were up to eleven times larger than average costs and dependent on the response in the WtE plant. Marginal cost of diversion were between 39 and 287 € Mg(-1) target fraction when biomass was added in a CHP (from 34 to 303 € Mg(-1) target fraction in the only Power case), between -2 and 300 € Mg(-1) target fraction when RDF was added in a CHP (from -2 to 294 € Mg(-1) target fraction in the only Power case) and between 40 and 303 € Mg(-1) target fraction when no reaction happened in a CHP (from 35 to 296 € Mg(-1) target fraction in the only Power case). Although average costs at WtE facilities were highly influenced by energy selling prices, marginal costs were not (provided a response was initiated at the WtE to keep constant the utilized thermal capacity). Failing to systematically address and include costs in existing waste facilities in decision-making may unintendedly lead to higher overall costs at societal level. To avoid misleading conclusions, economic assessment of alternative SWM solutions should not only consider potential costs associated with alternative treatment but also include marginal costs associated with existing facilities. Copyright © 2016 Elsevier Ltd. All rights reserved.

Techno-economic study of a distributed hybrid renewable energy system supplying electrical power and heat for a rural house in China

NASA Astrophysics Data System (ADS)

Yuan, Jindou; Xu, Jinliang; Wang, Yaodong

2018-03-01

Energy saving and emission reduction have become targets for modern society due to the potential energy crisis and the threat of climate change. A distributed hybrid renewable energy system (HRES) consists of photovoltaic (PV) arrays, a wood-syngas combined heat and power generator (CHP) and back-up batteries is designed to power a typical semi-detached rural house in China which aims to meet the energy demand of a house and to reduce greenhouse gas emissions from the use of fossil fuels. Based on the annual load information of the house and the local meteorological data including solar radiation, air temperature, etc., a system model is set up using HOMER software and is used to simulate all practical configurations to carry out technical and economic evaluations. The performance of the whole HRES system and each component under different configurations are evaluated. The optimized configuration of the system is found

Modeling of thermal storage systems in MILP distributed energy resource models

DOE PAGES

Steen, David; Stadler, Michael; Cardoso, Gonçalo; ...

2014-08-04

Thermal energy storage (TES) and distributed generation technologies, such as combined heat and power (CHP) or photovoltaics (PV), can be used to reduce energy costs and decrease CO 2 emissions from buildings by shifting energy consumption to times with less emissions and/or lower energy prices. To determine the feasibility of investing in TES in combination with other distributed energy resources (DER), mixed integer linear programming (MILP) can be used. Such a MILP model is the well-established Distributed Energy Resources Customer Adoption Model (DER-CAM); however, it currently uses only a simplified TES model to guarantee linearity and short run-times. Loss calculationsmore » are based only on the energy contained in the storage. This paper presents a new DER-CAM TES model that allows improved tracking of losses based on ambient and storage temperatures, and compares results with the previous version. A multi-layer TES model is introduced that retains linearity and avoids creating an endogenous optimization problem. The improved model increases the accuracy of the estimated storage losses and enables use of heat pumps for low temperature storage charging. Ultimately,results indicate that the previous model overestimates the attractiveness of TES investments for cases without possibility to invest in heat pumps and underestimates it for some locations when heat pumps are allowed. Despite a variation in optimal technology selection between the two models, the objective function value stays quite stable, illustrating the complexity of optimal DER sizing problems in buildings and microgrids.« less

Life-cycle energy use and greenhouse gas emissions of production of bioethanol from sorghum in the United States.

PubMed

Cai, Hao; Dunn, Jennifer B; Wang, Zhichao; Han, Jeongwoo; Wang, Michael Q

2013-10-02

The availability of feedstock options is a key to meeting the volumetric requirement of 136.3 billion liters of renewable fuels per year beginning in 2022, as required in the US 2007 Energy Independence and Security Act. Life-cycle greenhouse gas (GHG) emissions of sorghum-based ethanol need to be assessed for sorghum to play a role in meeting that requirement. Multiple sorghum-based ethanol production pathways show diverse well-to-wheels (WTW) energy use and GHG emissions due to differences in energy use and fertilizer use intensity associated with sorghum growth and differences in the ethanol conversion processes. All sorghum-based ethanol pathways can achieve significant fossil energy savings. Relative to GHG emissions from conventional gasoline, grain sorghum-based ethanol can reduce WTW GHG emissions by 35% or 23%, respectively, when wet or dried distillers grains with solubles (DGS) is the co-product and fossil natural gas (FNG) is consumed as the process fuel. The reduction increased to 56% or 55%, respectively, for wet or dried DGS co-production when renewable natural gas (RNG) from anaerobic digestion of animal waste is used as the process fuel. These results do not include land-use change (LUC) GHG emissions, which we take as negligible. If LUC GHG emissions for grain sorghum ethanol as estimated by the US Environmental Protection Agency (EPA) are included (26 g CO2e/MJ), these reductions when wet DGS is co-produced decrease to 7% or 29% when FNG or RNG is used as the process fuel. Sweet sorghum-based ethanol can reduce GHG emissions by 71% or 72% without or with use of co-produced vinasse as farm fertilizer, respectively, in ethanol plants using only sugar juice to produce ethanol. If both sugar and cellulosic bagasse were used in the future for ethanol production, an ethanol plant with a combined heat and power (CHP) system that supplies all process energy can achieve a GHG emission reduction of 70% or 72%, respectively, without or with vinasse fertigation. Forage sorghum-based ethanol can achieve a 49% WTW GHG emission reduction when ethanol plants meet process energy demands with CHP. In the case of forage sorghum and an integrated sweet sorghum pathway, the use of a portion of feedstock to fuel CHP systems significantly reduces fossil fuel consumption and GHG emissions. This study provides new insight into life-cycle energy use and GHG emissions of multiple sorghum-based ethanol production pathways in the US. Our results show that adding sorghum feedstocks to the existing options for ethanol production could help in meeting the requirements for volumes of renewable, advanced and cellulosic bioethanol production in the US required by the EPA's Renewable Fuel Standard program.

Life-cycle energy use and greenhouse gas emissions of production of bioethanol from sorghum in the United States

PubMed Central

2013-01-01

Background The availability of feedstock options is a key to meeting the volumetric requirement of 136.3 billion liters of renewable fuels per year beginning in 2022, as required in the US 2007 Energy Independence and Security Act. Life-cycle greenhouse gas (GHG) emissions of sorghum-based ethanol need to be assessed for sorghum to play a role in meeting that requirement. Results Multiple sorghum-based ethanol production pathways show diverse well-to-wheels (WTW) energy use and GHG emissions due to differences in energy use and fertilizer use intensity associated with sorghum growth and differences in the ethanol conversion processes. All sorghum-based ethanol pathways can achieve significant fossil energy savings. Relative to GHG emissions from conventional gasoline, grain sorghum-based ethanol can reduce WTW GHG emissions by 35% or 23%, respectively, when wet or dried distillers grains with solubles (DGS) is the co-product and fossil natural gas (FNG) is consumed as the process fuel. The reduction increased to 56% or 55%, respectively, for wet or dried DGS co-production when renewable natural gas (RNG) from anaerobic digestion of animal waste is used as the process fuel. These results do not include land-use change (LUC) GHG emissions, which we take as negligible. If LUC GHG emissions for grain sorghum ethanol as estimated by the US Environmental Protection Agency (EPA) are included (26 g CO2e/MJ), these reductions when wet DGS is co-produced decrease to 7% or 29% when FNG or RNG is used as the process fuel. Sweet sorghum-based ethanol can reduce GHG emissions by 71% or 72% without or with use of co-produced vinasse as farm fertilizer, respectively, in ethanol plants using only sugar juice to produce ethanol. If both sugar and cellulosic bagasse were used in the future for ethanol production, an ethanol plant with a combined heat and power (CHP) system that supplies all process energy can achieve a GHG emission reduction of 70% or 72%, respectively, without or with vinasse fertigation. Forage sorghum-based ethanol can achieve a 49% WTW GHG emission reduction when ethanol plants meet process energy demands with CHP. In the case of forage sorghum and an integrated sweet sorghum pathway, the use of a portion of feedstock to fuel CHP systems significantly reduces fossil fuel consumption and GHG emissions. Conclusions This study provides new insight into life-cycle energy use and GHG emissions of multiple sorghum-based ethanol production pathways in the US. Our results show that adding sorghum feedstocks to the existing options for ethanol production could help in meeting the requirements for volumes of renewable, advanced and cellulosic bioethanol production in the US required by the EPA’s Renewable Fuel Standard program. PMID:24088388

Guide to Using Combined Heat and Power for Enhancing Reliability and Resiliency in Buildings

EPA Pesticide Factsheets

This guide provides an overview of CHP and examples of how this technology can help improve the resilience and reliability of key infrastructure, and is intended to assist those involved in the Hurricane Sandy rebuilding process.

DECREASED HEART RATE IS ASSOCIATED WITH CARBAMATE-INDUCED ACTIVATION OF PRO-INFLAMMATORY SERUM PROTEINS.

EPA Science Inventory

Previously we reported that chlorpyrifos (CHP), an irreversible cholinesterase (ChE) inhibitor, induces hypertension in rats. Concomitant with hypertension, we found an increase in C-reactive protein, macrophage inflammatory protein-2 , monocyte chemotactic protein-5 and interfer...

Efficiency optimization of a closed indirectly fired gas turbine cycle working under two variable-temperature heat reservoirs

NASA Astrophysics Data System (ADS)

Ma, Zheshu; Wu, Jieer

2011-08-01

Indirectly or externally fired gas turbines (IFGT or EFGT) are interesting technologies under development for small and medium scale combined heat and power (CHP) supplies in combination with micro gas turbine technologies. The emphasis is primarily on the utilization of the waste heat from the turbine in a recuperative process and the possibility of burning biomass even "dirty" fuel by employing a high temperature heat exchanger (HTHE) to avoid the combustion gases passing through the turbine. In this paper, finite time thermodynamics is employed in the performance analysis of a class of irreversible closed IFGT cycles coupled to variable temperature heat reservoirs. Based on the derived analytical formulae for the dimensionless power output and efficiency, the efficiency optimization is performed in two aspects. The first is to search the optimum heat conductance distribution corresponding to the efficiency optimization among the hot- and cold-side of the heat reservoirs and the high temperature heat exchangers for a fixed total heat exchanger inventory. The second is to search the optimum thermal capacitance rate matching corresponding to the maximum efficiency between the working fluid and the high-temperature heat reservoir for a fixed ratio of the thermal capacitance rates of the two heat reservoirs. The influences of some design parameters on the optimum heat conductance distribution, the optimum thermal capacitance rate matching and the maximum power output, which include the inlet temperature ratio of the two heat reservoirs, the efficiencies of the compressor and the gas turbine, and the total pressure recovery coefficient, are provided by numerical examples. The power plant configuration under optimized operation condition leads to a smaller size, including the compressor, turbine, two heat reservoirs and the HTHE.

A comparison of health-related quality of life in idiopathic pulmonary fibrosis and chronic hypersensitivity pneumonitis.

PubMed

Lubin, Molly; Chen, Hubert; Elicker, Brett; Jones, Kirk D; Collard, Harold R; Lee, Joyce S

2014-06-01

Patients with interstitial lung disease (ILD) have poor health-related quality of life (HRQL). However, whether HRQL differs among different subtypes of ILD is unclear. The aim of this study was to determine whether HRQL was different among patients with idiopathic pulmonary fibrosis (IPF) and chronic hypersensitivity pneumonitis (CHP). We identified patients from an ongoing longitudinal cohort of patients with ILD. HRQL was assessed using the Short Form (SF)-36 medical outcomes form (version 2.0). Regression analysis was used to determine the association between clinical covariates and HRQL, primarily the physical component summary (PCS) and mental component summary (MCS) score. A multivariate regression model was created to identify potential covariates that could help explain the association between the ILD subtype and HRQL. Patients with IPF (n = 102) were older, more likely to be men, and more likely to have smoked. Pulmonary function was similar between the groups. The patients with CHP (n = 69) had worse HRQL across all eight domains of the SF-36, as well as the PCS and MCS, compared with patients with IPF (P < .01-.09). This pattern remained after controlling for age and pulmonary function (P < .01-.02). Covariates explaining part of the relationship between disease subtype and PCS score included severity of dyspnea (P < .01) and fatigue (P < .01). Covariates explaining part of the relationship between disease subtype and MCS score included severity of dyspnea (P < .01), female sex (P = .02), and fatigue (P = .02). HRQL is worse in CHP compared with IPF. HRQL differences between ILD subtypes are explained in part by differences in sex, dyspnea, and fatigue.

Menisci of the rabbit knee require mechanical loading to maintain homeostasis: cyclic hydrostatic compression in vitro prevents derepression of catabolic genes.

PubMed

Natsu-Ume, Takashi; Majima, Tokifumi; Reno, Carol; Shrive, Nigel G; Frank, Cyril B; Hart, David A

2005-07-01

The purpose of this study was to examine the influence of removing menisci from their in vivo loading environment on gene expression patterns and to determine whether in vitro loading can maintain the tissues in their in vivo phenotype. Lateral and medial rabbit meniscal explants from one leg were cultured in vitro and subjected to intermittent cyclic hydrostatic pressure (CHP) of 1 MPa at 0.5 Hz for 1 min and a rest period of 14 min (4 h of culture). The contralateral menisci were incubated at atmospheric pressure for 4 h. Menisci from both legs of another set of rabbits were frozen immediately to yield time zero values reflective of in vivo mRNA levels. Total RNA was isolated from all groups and processed for reverse transcription-polymerase chain reaction analysis for a subset of relevant genes (matrix molecules, cytokines, proteinases and inhibitors, enzymes). It was found that mRNA levels for MMP-1, MMP-3, TIMPs, iNOS, COX-2, interleukin-1beta in both menisci, and interleukin-6 in medial menisci were significantly elevated in tissues cultured under nonloading conditions compared to the time zero controls. Subjecting menisci to CHP significantly prevented these increases in mRNA levels for nearly all of the indicated molecules. In contrast, there were no significant differences in mRNA levels for collagens, biglycan, MMP-13, or TIMP-4 between the time zero values and those cultured under either nonloading or loading conditions. These studies demonstrate that removing rabbit menisci from their normal in vivo mechanical environment leads to an apparent up-regulation of a subset of potent effector molecules that could mediate catabolic activities, and that in vitro CHP can largely prevent this apparent up-regulation.

Detection of Aggregatibacter actinomycetemcomitans leukotoxin and fimbria-associated protein gene genotypes among periodontitis patients and healthy controls: A case–control study

PubMed Central

Mahalakshmi, Krishnan; Krishnan, Padma; Chandrasekaran, S. C.

2018-01-01

Background: Aggregatibacter actinomycetemcomitans has been reported in higher proportions in subgingival microbiota of individuals with aggressive periodontitis (AgP) compared with those with chronic periodontitis (ChP) and healthy controls. The major virulence factors are the ones that help in colonization and evasion of host's defenses. Hence, this study was aimed to assess the prevalence of A. actinomycetemcomitans 16S rRNA and its virulent genotypes (leukotoxin [lktA] and fimbria-associated protein [fap]). Materials and Methods: In this case– control study We performed periodontal examination and measured probing depth and clinical attachment level (CAL). Subgingival plaque samples from 200 (ChP: n = 128 and AgP: n = 72) periodontitis patients and 200 healthy controls were screened for the presence of A. actinomycetemcomitans 16S rRNA, lktA, and fap genotypes by polymerase chain reaction. The prevalence of genotypes between periodontitis patients and healthy controls was compared with Pearson's Chi-square test. P < 0.05 was considered statistically significant. Results: Mean pocket probing depth and CAL were high as compared to the healthy controls. The prevalence of A. actinomycetemcomitans in ChP (n = 128), AgP (n = 72), and healthy individuals (n = 200) was 32.0%, 61.1%, and 2.5%, respectively. A. actinomycetemcomitans lktA genotype prevalence was 71.8% among periodontitis patients, while A. actinomycetemcomitans fap genotype showed 31.8% prevalence. The prevalence of these genotypes was insignificant in healthy controls. Conclusion: The high odds ratio for A. actinomycetemcomitans prevalence suggests its strong link to periodontitis. Detection of A. actinomycetemcomitans lktA + genotype may be a useful marker for AgP as its prevalence was found to be high in AgP. PMID:29922337

Hydraulic Pressure during Fluid Flow Regulates Purinergic Signaling and Cytoskeleton Organization of Osteoblasts.

PubMed

Gardinier, Joseph D; Gangadharan, Vimal; Wang, Liyun; Duncan, Randall L

2014-06-01

During physiological activities, osteoblasts experience a variety of mechanical forces that stimulate anabolic responses at the cellular level necessary for the formation of new bone. Previous studies have primarily investigated the osteoblastic response to individual forms of mechanical stimuli. However in this study, we evaluated the response of osteoblasts to two simultaneous, but independently controlled stimuli; fluid flow-induced shear stress (FSS) and static or cyclic hydrostatic pressure (SHP or CHP, respectively). MC3T3-E1 osteoblasts-like cells were subjected to 12dyn/cm 2 FSS along with SHP or CHP of varying magnitudes to determine if pressure enhances the anabolic response of osteoblasts during FSS. For both SHP and CHP, the magnitude of hydraulic pressure that induced the greatest release of ATP during FSS was 15 mmHg. Increasing the hydraulic pressure to 50 mmHg or 100 mmHg during FSS attenuated the ATP release compared to 15 mmHg during FSS. Decreasing the magnitude of pressure during FSS to atmospheric pressure reduced ATP release to that of basal ATP release from static cells and inhibited actin reorganization into stress fibers that normally occurred during FSS with 15 mmHg of pressure. In contrast, translocation of nuclear factor kappa B (NFκB) to the nucleus was independent of the magnitude of hydraulic pressure and was found to be mediated through the activation of phospholipase-C (PLC), but not src kinase. In conclusion, hydraulic pressure during FSS was found to regulate purinergic signaling and actin cytoskeleton reorganization in the osteoblasts in a biphasic manner, while FSS alone appeared to stimulate NFκB translocation. Understanding the effects of hydraulic pressure on the anabolic responses of osteoblasts during FSS may provide much needed insights into the physiologic effects of coupled mechanical stimuli on osteogenesis.

Hydraulic Pressure during Fluid Flow Regulates Purinergic Signaling and Cytoskeleton Organization of Osteoblasts

PubMed Central

Gardinier, Joseph D.; Gangadharan, Vimal; Wang, Liyun; Duncan, Randall L.

2014-01-01

During physiological activities, osteoblasts experience a variety of mechanical forces that stimulate anabolic responses at the cellular level necessary for the formation of new bone. Previous studies have primarily investigated the osteoblastic response to individual forms of mechanical stimuli. However in this study, we evaluated the response of osteoblasts to two simultaneous, but independently controlled stimuli; fluid flow-induced shear stress (FSS) and static or cyclic hydrostatic pressure (SHP or CHP, respectively). MC3T3-E1 osteoblasts-like cells were subjected to 12dyn/cm2 FSS along with SHP or CHP of varying magnitudes to determine if pressure enhances the anabolic response of osteoblasts during FSS. For both SHP and CHP, the magnitude of hydraulic pressure that induced the greatest release of ATP during FSS was 15 mmHg. Increasing the hydraulic pressure to 50 mmHg or 100 mmHg during FSS attenuated the ATP release compared to 15 mmHg during FSS. Decreasing the magnitude of pressure during FSS to atmospheric pressure reduced ATP release to that of basal ATP release from static cells and inhibited actin reorganization into stress fibers that normally occurred during FSS with 15 mmHg of pressure. In contrast, translocation of nuclear factor kappa B (NFκB) to the nucleus was independent of the magnitude of hydraulic pressure and was found to be mediated through the activation of phospholipase-C (PLC), but not src kinase. In conclusion, hydraulic pressure during FSS was found to regulate purinergic signaling and actin cytoskeleton reorganization in the osteoblasts in a biphasic manner, while FSS alone appeared to stimulate NFκB translocation. Understanding the effects of hydraulic pressure on the anabolic responses of osteoblasts during FSS may provide much needed insights into the physiologic effects of coupled mechanical stimuli on osteogenesis. PMID:24910719

Relative Contribution of nirK- and nirS- Bacterial Denitrifiers as Well as Fungal Denitrifiers to Nitrous Oxide Production from Dairy Manure Compost.

PubMed

Maeda, Koki; Toyoda, Sakae; Philippot, Laurent; Hattori, Shohei; Nakajima, Keiichi; Ito, Yumi; Yoshida, Naohiro

2017-12-19

The relative contribution of fungi, bacteria, and nirS and nirK denirifiers to nitrous oxide (N 2 O) emission with unknown isotopic signature from dairy manure compost was examined by selective inhibition techniques. Chloramphenicol (CHP), cycloheximide (CYH), and diethyl dithiocarbamate (DDTC) were used to suppress the activity of bacteria, fungi, and nirK-possessing denitrifiers, respectively. Produced N 2 O were surveyed to isotopocule analysis, and its 15 N site preference (SP) and δ 18 O values were compared. Bacteria, fungi, nirS, and nirK gene abundances were compared by qPCR. The results showed that N 2 O production was strongly inhibited by CHP addition in surface pile samples (82.2%) as well as in nitrite-amended core samples (98.4%), while CYH addition did not inhibit the N 2 O production. N 2 O with unknown isotopic signature (SP = 15.3-16.2‰), accompanied by δ 18 O (19.0-26.8‰) values which were close to bacterial denitrification, was also suppressed by CHP and DDTC addition (95.3%) indicating that nirK denitrifiers were responsible for this N 2 O production despite being less abundant than nirS denitrifiers. Altogether, our results suggest that bacteria are important for N 2 O production with different SP values both from compost surface and pile core. However, further work is required to decipher whether N 2 O with unknown isotopic signature is mostly due to nirK denitrifiers that are taxonomically different from the SP-characterized strains and therefore have different SP values rather than also being interwoven with the contribution of the NO-detoxifying pathway and/or of co-denitrification.

78 FR 26677 - Self-Regulatory Organizations; NYSE MKT LLC; Notice of Filing and Immediate Effectiveness of...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-07

... rebate, Customer to Customer QCC trades will not qualify for any rebate as such a transaction nets the...Viewer.asp?selectednode=chp_1_4&manual=%2Fnasdaqomxphlx%2Fphlx%2Fphlx-rulesbrd%2F . 2. Statutory Basis...

THE EFFECTS OF CHRONIC EXERCISE CONDITIONING ON THERMOREGULATORY RESPONSE TO CHLORPYRIFOS IN FEMALE RATS.

EPA Science Inventory

Chronic exercise conditioning has been shown to alter basal thermoregulatory processes (change in thermoregulatory set-point) as well as the response to infectious fever. Chlorpyrifos (CHP), an organophosphate pesticide, causes an acute period of hypothermia followed by a delaye...

Waste-Heat-to-Power Market in the U.S., Heat is Power Annual Meeting (Presentation) – August 15, 2012

EPA Pesticide Factsheets

This presentation provides information about the EPA CHP Partnership, including an overview of the Partnership's tools and resources, and policy support. The presentation also describes the potential of Waste Heat to Power (WHP) systems.

Impact of Fetal Versus Perinatal Hypoxia on Sex Differences in Childhood Outcomes: Developmental Timing Matters

PubMed Central

Anastario, Michael; Salafia, Carolyn M.; Fitzmaurice, Garrett; Goldstein, Jill M.

2013-01-01

Purpose To examine how the timing of hypoxic exposure results in specific childhood outcomes and whether there is a differential effect by sex. Methods A sample of 10,879 prospectively followed pregnancies was drawn from the Boston and Providence sites (New England-NE) of the National Collaborative Perinatal Project. Based on placental pathology, we developed and validated a measure of probable chronic fetal hypoxia (CHP) and contrasted the effects of acute perinatal hypoxia on age 7 emotional, behavioral, and cognitive outcomes. Results Perinatal hypoxia had a significant impact on multiple behavioral and cognitive outcomes in boys and girls by age 7, in contrast to probable CHP which had a differential effect on girls and boys such that there was decreased verbal IQ and increased inhibition in females alone. Conclusions Findings underscore the importance of considering the timing of obstetric complications and offspring sex in investigations of the impact of fetal and perinatal hypoxia on offspring’s outcomes throughout the life course. PMID:21327969

The endobacterium of an arbuscular mycorrhizal fungus modulates the expression of its toxin-antitoxin systems during the life cycle of its host.

PubMed

Salvioli di Fossalunga, Alessandra; Lipuma, Justine; Venice, Francesco; Dupont, Laurence; Bonfante, Paola

2017-10-01

Arbuscular mycorrhizal fungi (AMF) are widespread root symbionts that perform important ecological services, such as improving plant nutrient and water acquisition. Some AMF from the Gigasporaceae family host a population of endobacteria, Candidatus Glomeribacter gigasporarum (Cagg). The analysis of the Cagg genome identified six putative toxin-antitoxin modules (TAs), consisting of pairs of stable toxins and unstable antitoxins that affect diverse physiological functions. Sequence analysis suggested that these TA modules were acquired by horizontal transfer. Gene expression patterns of two TAs (yoeB/yefM and chpB/chpS) changed during the fungal life cycle, with the expression during the pre-symbiotic phase higher than during the symbiosis with the plant host. The heterologous expression in Escherichia coli demonstrated the functionality only for the YoeB-YefM pair. On the basis of these observations, we speculate that TA modules might help Cagg adapt to its intracellular habitat, coordinating its proliferation with the physiological state of the AMF host.

Material flow and sustainability analyses of biorefining of municipal solid waste.

PubMed

Sadhukhan, Jhuma; Martinez-Hernandez, Elias

2017-11-01

This paper presents material flow and sustainability analyses of novel mechanical biological chemical treatment system for complete valorization of municipal solid waste (MSW). It integrates material recovery facility (MRF); pulping, chemical conversion; effluent treatment plant (ETP), anaerobic digestion (AD); and combined heat and power (CHP) systems producing end products: recyclables (24.9% by mass of MSW), metals (2.7%), fibre (1.5%); levulinic acid (7.4%); recyclable water (14.7%), fertiliser (8.3%); and electricity (0.126MWh/t MSW), respectively. Refuse derived fuel (RDF) and non-recyclable other waste, char and biogas from MRF, chemical conversion and AD systems, respectively, are energy recovered in the CHP system. Levulinic acid gives profitability independent of subsidies; MSW priced at 50Euro/t gives a margin of 204Euro/t. Global warming potential savings are 2.4 and 1.3kg CO 2 equivalent per kg of levulinic acid and fertiliser, and 0.17kg CO 2 equivalent per MJ of grid electricity offset, respectively. Copyright © 2017 Elsevier Ltd. All rights reserved.

Energy Saving and GHG Emission Reduction in a Micro-CCHP System by Use of Solar Energy

NASA Astrophysics Data System (ADS)

Ion, Ion V.; Ciocea, Gheorghe; Popescu, Florin

2012-12-01

In this work, the reduction of greenhouse gas emission, and the energy saving by integrating solar collectors and photovoltaic panels in a Stirling engine based microcombined cooling, heating and power (mCCHP) system are studied. The mCCHP system consists of a natural gas Stirling CHP and an adsorber chiller. When the thermal outputs of the Stirling CHP and solar collectors are not sufficient to cover the heat demand for domestic hot water (DHW), heating/cooling, an auxiliary heating boiler starts to operate. The energy saving by using solar energy varies from 13.35% in December to 59.62% in April, in the case of solar collectors usage and from 7.47% in December to 28.27% in July, in the case of photovoltaic panels usage. By using solar energy the annual GHG emission decreases by 31.98% and the fuel cost reduction varies from 12.73% in December to 49.78% in June.

Testing and model-aided analysis of a 2 kW el PEMFC CHP-system

NASA Astrophysics Data System (ADS)

König, P.; Weber, A.; Lewald, N.; Aicher, T.; Jörissen, L.; Ivers-Tiffée, E.; Szolak, R.; Brendel, M.; Kaczerowski, J.

A prototype PEMFC CHP-system (combined heat and power) for decentralised energy supply in domestic applications has been installed in the Fuel Cell Testing Laboratory at the Institut für Werkstoffe der Elektrotechnik (IWE), Universität Karlsruhe (TH). The system, which was developed at the Zentrum für Sonnenenergie- und Wasserstoff-Forschung ZSW, Ulm (FC-stack) and the Fraunhofer-Institut für Solare Energiesysteme ISE, Freiburg (reformer) is operated and tested in close cooperation with the Stadtwerke Karlsruhe. The tests are carried out as part of the strategic project EDISon, which is supported by the German Federal Ministry of Economics and Technology (BMWA). The performance of the system is evaluated for different operating conditions. The tests include steady state measurements under different electrical and thermal loads as well as an analysis of the dynamic behaviour of the system during load changes. First results of these steady state and dynamic operation characteristics will be presented in this paper.

Sequential use of hemoperfusion and single-pass albumin dialysis can safely reverse methotrexate nephrotoxicity.

PubMed

Chan, Winnie Kwai Yu; Hui, Wun Fung

2016-10-01

High-dose methotrexate therapy (HDMTX) is a common form of chemotherapy used in children with high-grade malignancy such as osteosarcoma. Treatment with HDMTX requires careful monitoring of drug levels with folinic acid (leucovorin) rescue therapy. Toxicity from methotrexate is not uncommon and sometimes causes significant morbidity and mortality. We report an 11-year-old child whose 24-h post-HDMTX serum level was 651.8 μmol/L (recommended level <20 μmol/L), which was complicated by septic shock and progressive renal and liver failure. As carboxypeptidase (glucarpidase) was not available locally, she was treated with the sequential use of charcoal hemoperfusion (CHP) and single-pass albumin dialysis (SPAD). The patient recovered without complications. Both liver and renal function recovered with no significant late sequelae. CHP and SPAD are effective extracorporeal methods of removing methotrexate. They provide alternative treatment options for critical care nephrologists in the management of methotrexate toxicity.

78 FR 44104 - Notice of Intent To Issue a Funding Opportunity Announcement; Technical Assistance

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-23

... Funding Opportunity Announcement; Technical Assistance AGENCY: Federal Energy Management Program, Office.... This notice also is to inform Federal agencies of the availability of technical assistance in advance.... FOR FURTHER INFORMATION CONTACT: For requests for technical assistance regarding CHP, please contact...

Gasification of blended animal manures to produce synthesis gas and activated charcoal

USDA-ARS?s Scientific Manuscript database

Blended swine solids, chicken litter, and hardwood are renewable and expensive sources to produce combined heat and power (CHP), fuels and related chemicals. The therrmochemical pathway to gasify manure has the added advantage of destroying harmful pathogens and pharmaceutically active compounds dur...

Wood-fired fuel cells in selected buildings

NASA Astrophysics Data System (ADS)

McIlveen-Wright, D. R.; McMullan, J. T.; Guiney, D. J.

The positive attributes of fuel cells for high efficiency power generation at any scale and of biomass as a renewable energy source which is not intermittent, location-dependent or very difficult to store, suggest that a combined heat and power (CHP) system consisting of a fuel cell integrated with a wood gasifier (FCIWG) may offer a combination for delivering heat and electricity cleanly and efficiently. Phosphoric acid fuel cell (PAFC) systems, fuelled by natural gas, have already been used in a range of CHP applications in urban settings. Some of these applications are examined here using integrated biomass gasification/fuel cell systems in CHP configurations. Five building systems, which have different energy demand profiles, are assessed. These are a hospital, a hotel, a leisure centre, a multi-residential community and a university hall of residence. Heat and electricity use profiles for typical examples of these buildings were obtained and the FCIWG system was scaled to the power demand. The FCIWG system was modelled for two different types of fuel cell, the molten carbonate and the phosphoric acid. In each case an oxygen-fired gasification system is proposed, in order to eliminate the need for a methane reformer. Technical, environmental and economic analyses of each version were made, using the ECLIPSE process simulation package. Since fuel cell lifetimes are not yet precisely known, economics for a range of fuel cell lifetimes have been produced. The wood-fired PAFC system was found to have low electrical efficiency (13-16%), but much of the heat could be recovered, so that the overall efficiency was 64-67%, suitable where high heat/electricity values are required. The wood-fired molten carbonate fuel cell (MCFC) system was found to be quite efficient for electricity generation (24-27%), with an overall energy efficiency of 60-63%. The expected capital costs of both systems would currently make them uncompetitive for general use, but the specific features of selected buildings in rural areas, with regard to the high cost of importing other fuel, and/or lack of grid electricity, could still make these systems attractive options. Any economic analysis of these systems is beset with severe difficulties. Capital costs of the major system components are not known with any great precision. However, a guideline assessment of the payback period for such CHP systems was made. When the best available capital costs for system components were used, most of these systems were found to have unacceptably long payback periods, particularly where the fuel cell lifetimes are short, but the larger systems show the potential for a reasonable economic return.

Derate Mitigation Options for Pulverized Coal Power Plant Carbon Capture Retrofits

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hoffmann, Jeffrey W.; Hackett, Gregory A.; Lewis, Eric G.

Carbon capture and storage (CCS) technologies available in the near-term for pulverized coal-fueled power plants (i.e., post combustion solvent technologies) require substantial capital investment and result in marked decrease in electricity available for sale to the grid. The impact to overall plant economics can be mitigated for new plant designs (where the entire plant can be optimized around the CCS system). However, existing coal-fueled power plants were designed without the knowledge or intent to retrofit a CCS process, and it is simply not possible to re-engineer an existing plant in a manner that it could achieve the same performance asmore » if it was originally designed and optimized for CCS technology. Pairing an auxiliary steam supply to the capture system is a technically feasible option to mitigate the derate resulting from diverting steam away from an existing steam turbine and continuing to run that turbine at steam flow rates and properties outside of the original design specifications. The results of this analysis strongly support the merits of meeting the steam and power requirements for a retrofitted post-combustion solvent based carbon dioxide (CO2) capture system with an auxiliary combined heat and power (CHP) plant rather than robbing the base plant (i.e., diverting steam from the existing steam cycle and electricity from sale to the grid).« less

ETV/COMBINED HEAT AND POWER AT A COMMERCIAL SUPERMARKET CAPSTONE 60 KW MICROTURBINE SYSTEM

EPA Science Inventory

The Environmental Technology Verification report discusses the technology and performance of the Capstone 60 Microturbine CHP System manufactured by Capstone Microturbine Corporation. This system is a 60 kW electrical generator that puts out 480 v AC at 60 Hz and that is driven b...

76 FR 72216 - Occupational Exposure to Hazardous Chemicals in Laboratories Standard; Extension of the Office of...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-22

... by developing a written Chemical Hygiene Plan (CHP) that describes standard operating procedures for...] Occupational Exposure to Hazardous Chemicals in Laboratories Standard; Extension of the Office of Management... requirements specified in the Standard on Occupational Exposure to Hazardous Chemicals in Laboratories (29 CFR...

Public Health Information and a Diverse Population.

ERIC Educational Resources Information Center

Perkins, Mark

This paper discusses public health services of the Secretariat of the Pacific Community (SPC). The paper provides an overview of SPC and the Pacific Islands, including geography, nationality/culture, and development status. SPC Community Health Programmes (CHP) in the following areas are then described: environmental health; AIDS and STD (sexually…

Study of the Subarea Approach to Health Manpower Planning.

ERIC Educational Resources Information Center

Comprehensive Health Planning, Inc., Chicago, IL.

Recognizing the need for a health manpower planning system that would insure the recruitment, training, utilization, and retention of area residents as skilled providers of health care, Comprehensive Health Planning, Inc., Metropolitan Chicago (CHP), and the West Side Health Planning Organization (WSHPO) embarked on a 1-year project to demonstrate…

Proceedings of the 1st Army Installation Energy Security and Independence Conference

DTIC Science & Technology

2007-03-01

robustness of Transmission and Distribution system, and that pro- motes the use of demand response, CHP, and use of renewable intermit - ERDC/CERL TR...charged during low load periods. • Generation is run at optimum level during high loads. • Storage follows load and provides fast power balance during

Carbon Emissions Trading and Combined Heat and Power Strategies: Unintended Consequences

ERIC Educational Resources Information Center

Tysseling, John C.; Vosevich, Mary; Boersma, Benjamin R.; Zumwalt, Jefferey A.

2009-01-01

Facility professionals continuously search for projects that reduce energy consumption and operating costs so as to directly benefit their bottom line. Many institutions nationwide have contemplated or made investments in combined heat and power (CHP) projects as a life-cycle strategy to minimize operating costs. However, recent sustainability and…

The Children's Hearings Project Research Findings. A Summary Report.

ERIC Educational Resources Information Center

Merry, Sally E.; And Others

Since 1980 the Children's Hearings Project (CHP) in Cambridge, Massachusetts, has offered status offenders and their families mediation as an alternative to the courts. This report describes CPH's origins and summarizes the results of an extensive research study conducted during the first 2 years of its operation. The key findings were: (1)…

CHANGES IN THE RAT EEG SPECTRA AND CORE TEMPERATURE AFTER EXPOSURE TO DIFFERENT DOSES OF CHLORPYRIFOS.

EPA Science Inventory

Our previous study showed that single exposure to 25 mg/kg (p.o.) of organophsphate pesticide chlorpyrifos (CHP) led to significant alterations in all EEG frequency bands within 0.1-50 Hz range, reduction in core temperature (Tc) and motor activity (MA). The alterations in EEG pe...

Conceptual design of an integrated hydrothermal liquefaction and biogas plant for sustainable bioenergy production.

PubMed

Hoffmann, Jessica; Rudra, Souman; Toor, Saqib S; Holm-Nielsen, Jens Bo; Rosendahl, Lasse A

2013-02-01

Initial process studies carried out in Aspen Plus on an integrated thermochemical conversion process are presented herein. In the simulations, a hydrothermal liquefaction (HTL) plant is combined with a biogas plant (BP), such that the digestate from the BP is converted to a biocrude in the HTL process. This biorefinery concept offers a sophisticated and sustainable way of converting organic residuals into a range of high-value biofuel streams in addition to combined heat and power (CHP) production. The primary goal of this study is to provide an initial estimate of the feasibility of such a process. By adding a diesel-quality-fuel output to the process, the product value is increased significantly compared to a conventional BP. An input of 1000 kg h(-1) manure delivers approximately 30-38 kg h(-1) fuel and 38-61 kg h(-1) biogas. The biogas can be used to upgrade the biocrude, to supply the gas grid or for CHP. An estimated 62-84% of the biomass energy can be recovered in the biofuels. Copyright © 2012 Elsevier Ltd. All rights reserved.

s-core network decomposition: A generalization of k-core analysis to weighted networks

NASA Astrophysics Data System (ADS)

Eidsaa, Marius; Almaas, Eivind

2013-12-01

A broad range of systems spanning biology, technology, and social phenomena may be represented and analyzed as complex networks. Recent studies of such networks using k-core decomposition have uncovered groups of nodes that play important roles. Here, we present s-core analysis, a generalization of k-core (or k-shell) analysis to complex networks where the links have different strengths or weights. We demonstrate the s-core decomposition approach on two random networks (ER and configuration model with scale-free degree distribution) where the link weights are (i) random, (ii) correlated, and (iii) anticorrelated with the node degrees. Finally, we apply the s-core decomposition approach to the protein-interaction network of the yeast Saccharomyces cerevisiae in the context of two gene-expression experiments: oxidative stress in response to cumene hydroperoxide (CHP), and fermentation stress response (FSR). We find that the innermost s-cores are (i) different from innermost k-cores, (ii) different for the two stress conditions CHP and FSR, and (iii) enriched with proteins whose biological functions give insight into how yeast manages these specific stresses.

NASA Goddard Space Flight Center Cooperative Enterprise

NASA Technical Reports Server (NTRS)

Fredley, Joseph E.; Lysak, Daniel B.

2004-01-01

The viability of a Capillary Heat Pump (CHP) concept using a Loop Heat Pipe evaporator and an eductor in a closed loop to reject heat at a higher temperature than it is acquired at with the goal of reducing spacecraft radiator area is examined. Eductor inefficiency resulting from the mixing of high velocity motive flow with low velocity suction flow may preclude spacecraft radiator area savings. The utility of a CHP for thermal management may be limited to those missions where system mass is of secondary concern compared to system reliability, or where a heat pump is required to accommodate relatively high thermal rejection temperatures. Shearography techniques for nondestructive inspection and evaluation were examined for two unique applications. Shearography is shown to give good results in evaluating the quality of bonds holding lead tiles to the SWIFT spacecraft BAT gamma ray mask. Also, a novel technique was developed allowing specular objects to be inspected using shearography to evaluate bonding between the skin and core of a specular surface honeycomb structure. Large-scale bond failures are readily identified.

Modern European monographs for quality control of Chinese herbs.

PubMed

Bauer, Rudolf; Franz, Gerhard

2010-12-01

The actual concern about the safety and efficacy of herbal drugs originating from traditional Chinese medicine (TCM) is based on observations that these medicinal plants may have a high risk potential due to insufficient definitions, problems with identity, purity and falsifications. No uniform legal status for these groups of herbal drugs currently exists in the European Union. For quality control, monographs for TCM herbs can mainly be found in the Pharmacopoeia of the Peoples Republic of China. Based on these facts the Commission of the European Pharmacopoeia decided in 2005 to establish TCM-herbal drug monographs for the most important medicinal plants imported from Far East. These new monographs had to be established and evaluated on the basis of existing monographs in the Chinese Pharmacopoeia (ChP), English edition 2005. Due to important differences in the overall features of EP and ChP, a simple adapt/adopt procedure was not feasible. Therefore, specialist groups were mandated with a corresponding working programme. Some results and actual problems related to this working programme will be presented and discussed. © Georg Thieme Verlag KG Stuttgart · New York.

Configuring a fuel cell based residential combined heat and power system

NASA Astrophysics Data System (ADS)

Ahmed, Shabbir; Papadias, Dionissios D.; Ahluwalia, Rajesh K.

2013-11-01

The design and performance of a fuel cell based residential combined heat and power (CHP) system operating on natural gas has been analyzed. The natural gas is first converted to a hydrogen-rich reformate in a steam reformer based fuel processor, and the hydrogen is then electrochemically oxidized in a low temperature polymer electrolyte fuel cell to generate electric power. The heat generated in the fuel cell and the available heat in the exhaust gas is recovered to meet residential needs for hot water and space heating. Two fuel processor configurations have been studied. One of the configurations was explored to quantify the effects of design and operating parameters, which include pressure, temperature, and steam-to-carbon ratio in the fuel processor, and fuel utilization in the fuel cell. The second configuration applied the lessons from the study of the first configuration to increase the CHP efficiency. Results from the two configurations allow a quantitative comparison of the design alternatives. The analyses showed that these systems can operate at electrical efficiencies of ∼46% and combined heat and power efficiencies of ∼90%.

The experiences of health services research and health services research training in Korea.

PubMed

Moon, O R

1984-12-01

Early in the 1970s the Korean government recognized the necessity of Health Services Research (HSR). The law of the Korea Health Development Institute was promulgated in 1975, and a contribution from the Republic was combined with an Agency for International Development loan to field test low-cost health service strategies. A program to deploy Community Health Practitioners (CHPs), similar to family nurse practitioners or Medex has been demonstrated to be effective. The CHP training program grew from 9 in 1980 to 1343 in 1984. CHP's main functions are curative, preventive, educative, and administrative. They are selected registered nurses and/or midwives, where possible from serviced communities. They are trained in 24 weeks, including 12 weeks of clinical practice, in an anticipated recruiting post. CHPs help train village health volunteers (VHVs), who are literate women chosen by their communities. They work closely with the CHPs as a liaison with the village and in information gathering. An HSR orientation workshop held in Chuncheon in 1980, discussed role, policy, status, finance components, information systems, behavioral and manpower components, staff training, protocols for project development, HSR in the future and evaluation of the conference. In 1980, a National Workshop on Biomedical Research Methodology was also held, with World Health Organization and Korean consultants. Training of junior scientists would include introduction to scientific method, statement of problems, quantitative study technics, research proposals, and interpretation of results. The Korean Institute of Public Health sponsored a 1982 experts forum on the health care system, medical facilities, organizational management, financing and medical security, and health behavioral aspects. Training of trainers and lower level field workers, orientation of program managers, researchers, and communities themselves should all be training priorities. In future, CHPs should be refresher-trained in prevention-oriented care, and physicians educated in the benefits of CHP input as a complementary rather than competitive service.

Quantification of the reactions in heat storage systems in the Malm aquifer

NASA Astrophysics Data System (ADS)

Ueckert, Martina; Baumann, Thomas

2017-04-01

Combined heat and power plants (CHP) are efficient and environmentally friendly because excess heat produced during power generation is used for heating purposes. While the power demand remains rather constant throughout the year, the heat demand shows seasonal variations. In a worst-case scenario, the heat production in winter is not sufficient, and the power production in summer has to be ramped down because the excess heat cannot be released to the environment. Therefore, storage of excess heat of CHP is highly beneficial from an economic and an ecological point of view. Aquifer thermal energy storage (ATES) is considered as a promising technology for energy storage. In a typical setting, water from an aquifer is produced, heated up by excess heat from the CHP and injected through a second borehole back into the aquifer. The carbonate rocks of the upper Jurrasic in the Molasse Basin seem to be promising sites for aquifer heat storage because of their high transmissivity combined with a typical geological setting with tight caprock. However, reactions in the aquifer cannot be neglected and may become the limiting process of the whole operation. While there have been several studies performed in clastic aquifers and for temperatures below 100°C, the knowledge about high injection temperatures and storage into a carbonatic aquifer matrix is still limited. Within a research project funded by the Bavarian State Ministry for Economic Affairs and the BMW Group, the storage and recuperation of excess heat energy into the Bavarian Malm aquifer with flow rates of 15 L/s and temperatures of up to 110°C was investigated. The addition of {CO_2} was used to prevent precipitations. Data from the field site was backed up by autoclave experiments and used to verify a conceptional hydrogeochemical model with PhreeqC for the heat storage operation. The model allows to parametrize the operation and to predict possible reactions in the aquifer.

Lidar Altimeter Measurements of Canopy Structure: Methods and Validation for Closed Canopy, Broadleaf Forests

NASA Technical Reports Server (NTRS)

Harding, D. J.; Lefsky, M. A.; Parker, G. G.; Blair, J. B.

1999-01-01

Lidar altimeter observations of vegetated landscapes provide a time-resolved measure of laser pulse backscatter energy from canopy surfaces and the underlying ground. Airborne lidar altimeter data was acquired using the Scanning Lidar Imager of Canopies by Echo Recovery (SLICER) for a successional sequence of four, closed-canopy, deciduous forest stands in eastern Maryland. The four stands were selected so as to include a range of canopy structures of importance to forest ecosystem function, including variation in the height and roughness of the outer-most canopy surface and the vertical organization of canopy stories and gaps. The character of the SLICER backscatter signal is described and a method is developed that accounts for occlusion of the laser energy by canopy surfaces, transforming the backscatter signal to a canopy height profile (CHP) that quantitatively represents the relative vertical distribution of canopy surface area. The transformation applies an increased weighting to the backscatter amplitude as a function of closure through the canopy and assumes a horizontally random distribution of the canopy components. SLICER CHPs, averaged over areas of overlap where lidar ground tracks intersect, are shown to be highly reproducible. CHP transects across the four stands reveal spatial variations in vegetation, at the scale of the individual 10 m diameter laser footprints, within and between stands. Averaged SLICER CHPs are compared to analogous height profile results derived from ground-based sightings to plant intercepts measured on plots within the four stands. Tbe plots were located on the segments of the lidar ground tracks from which averaged SLICER CHPs were derived, and the ground observations were acquired within two weeks of the SLICER data acquisition to minimize temporal change. The differences in canopy structure between the four stands is similarly described by the SLICER and ground-based CHP results, however a Chi-square test of similarity documents differences that are statistically significant. The differences are discussed in terms of measurement properties that define the smoothness of the resulting CHPs and Lidar Altimeter Measurements of Canopy Structure - Harding et al. canopy properties that may vertically bias the CHP representations of canopy structure. The statistical differences are most likely due to the more noisy character of the ground-based CHPs, especially high in the canopy where ground-based sightings are rare resulting in an underestimate of canopy surface area and height, and to departures from the assumption of horizontal randomness which bias the CHPs toward the observer (upward for SLICER and downward for ground-based CHPs). The results demonstrate that the SLICER observations reliably provide a measure of canopy structure that reveals ecologically interesting structural variations such as those characterizing a successional sequence of closed-canopy, broadleaf forest stands.

The chemotaxis regulator pilG of Xylella fastidiosa is required for virulence in Vitis vinifera grapevines

USDA-ARS?s Scientific Manuscript database

Xylella fastidiosa is a Gram-negative, xylem-limited pathogenic bacterium that causes Pierce’s disease of grapevines. Type IV pili of X. fastidiosa are regulated by pilG, a chemotaxis regulator in Pil-Chp operon involving signal transduction pathways. To elucidate the role of pilG in twitching motil...

Improving Safety Data Collection, Access, and Analysis for California's Strategic Highway Safety Plan (SHSP): Proceedings from the Federal Highway Administration's Highway Safety Improvement Program (HSIP) Peer-to-Peer Exchange Program

DOT National Transportation Integrated Search

2010-09-28

This report provides a summary of a peer exchange sponsored by the California Office of Traffic Safety (OTS), California Department of Transportation (Caltrans), the California Highway Patrol (CHP), and the Federal Highway Administration (FHWA). The ...

Combined Heat & Power Using the Infinia Concentrated Solar - CHP PowerDish System

DTIC Science & Technology

2013-08-01

forward operating base FPSE Free Piston Stirling Engine GHG greenhouse gas IOU investor-owned utility kW kilowatt kWac kilowatt alternating...Free Piston Stirling Engine (FPSE) for military, commercial, and space applications for almost 30 years. As Infinia developed a commercial product...6 Figure 2. Free-piston Stirling generator. ................................................................................ 6 Figure 3

Annual Report on Electronics Research at the University of Texas at Austin.

DTIC Science & Technology

1984-05-15

Beall, E.J. Powers, Roger D. Bengtson and K. Nelin, "Edge Turbulence in TEXT and PRETEXT." Ch.P. Ritz , S.J. Levinson, E.J. Powers, and Roger D...DC 20234 314 Phillips Hall Ithaca, MY 1480 Ori. ay.Harris Office of the Dean Dr. Carlton Walter School of Engineering ElectroScionce Laboratory San

The potential for distributed generation in Japanese prototype buildings: A DER-CAM analysis of policy, tariff design, building energy use, and technology development (English Version)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhou, Nan; Marnay, Chris; Firestone, Ryan

The August 2003 blackout of the northeastern U.S. and CANADA caused great economic losses and inconvenience to New York City and other affected areas. The blackout was a warning to the rest of the world that the ability of conventional power systems to meet growing electricity demand is questionable. Failure of large power systems can lead to serious emergencies. Introduction of on-site generation, renewable energy such as solar and wind power and the effective utilization of exhaust heat is needed, to meet the growing energy demands of the residential and commercial sectors. Additional benefit can be achieved by integrating thesemore » distributed technologies into distributed energy resource (DER) systems. This work demonstrates a method for choosing and designing economically optimal DER systems. An additional purpose of this research is to establish a database of energy tariffs, DER technology cost and performance characteristics, and building energy consumption for Japan. This research builds on prior DER studies at the Ernest Orlando Lawrence Berkeley National Laboratory (LBNL) and with their associates in the Consortium for Electric Reliability Technology Solutions (CERTS) and operation, including the development of the microgrid concept, and the DER selection optimization program, the Distributed Energy Resources Customer Adoption Model (DER-CAM). DER-CAM is a tool designed to find the optimal combination of installed equipment and an idealized operating schedule to minimize a site's energy bills, given performance and cost data on available DER technologies, utility tariffs, and site electrical and thermal loads over a test period, usually an historic year. Since hourly electric and thermal energy data are rarely available, they are typically developed by building simulation for each of six end use loads used to model the building: electric-only loads, space heating, space cooling, refrigeration, water heating, and natural-gas-only loads. DER-CAM provides a global optimization, albeit idealized, that shows how the necessary useful energy loads can be provided for at minimum cost by selection and operation of on-site generation, heat recovery, cooling, and efficiency improvements. This study examines five prototype commercial buildings and uses DER-CAM to select the economically optimal DER system for each. The five building types are office, hospital, hotel, retail, and sports facility. Each building type was considered for both 5,000 and 10,000 square meter floor sizes. The energy consumption of these building types is based on building energy simulation and published literature. Based on the optimization results, energy conservation and the emissions reduction were also evaluated. Furthermore, a comparison study between Japan and the U.S. has been conducted covering the policy, technology and the utility tariffs effects on DER systems installations. This study begins with an examination of existing DER research. Building energy loads were then generated through simulation (DOE-2) and scaled to match available load data in the literature. Energy tariffs in Japan and the U.S. were then compared: electricity prices did not differ significantly, while commercial gas prices in Japan are much higher than in the U.S. For smaller DER systems, the installation costs in Japan are more than twice those in the U.S., but this difference becomes smaller with larger systems. In Japan, DER systems are eligible for a 1/3 rebate of installation costs, while subsidies in the U.S. vary significantly by region and application. For 10,000 m{sup 2} buildings, significant decreases in fuel consumption, carbon emissions, and energy costs were seen in the economically optimal results. This was most noticeable in the sports facility, followed the hospital and hotel. This research demonstrates that office buildings can benefit from CHP, in contrast to popular opinion. For hospitals and sports facilities, the use of waste heat is particularly effective for water and space heating. For the other building types, waste heat is most effectively used for both heating and cooling. The same examination was done for the 5,000 m{sup 2} buildings. Although CHP installation capacity is smaller and the payback periods are longer, economic, fuel efficiency, and environmental benefits are still seen. While these benefits remain even when subsidies are removed, the increased installation costs lead to lower levels of installation capacity and thus benefit.« less

Comparative Study on Oxidative Treatments of NAPL Containing Chlorinated Ethanes and Ethenes using Hydrogen Peroxide and Persulfate in Soils

EPA Science Inventory

The goal of this study was to assess the oxidation of NAPL in soil, 30% of which were composed of chlorinated ethanes and ethenes, using catalyzed hydrogen peroxide (CHP), activated persulfate (AP), and H2O2–persulfate (HP) co-amendment systems. Citrate, a buffer and iron ligand,...

Connecting for High Potential... "Here Comes Summer." CHP Issue 27

ERIC Educational Resources Information Center

Danielian, Jeff; Nilles, Kathleen

2015-01-01

Summer vacation is right around the corner! However, just as quickly as summer approaches, it also passes in the blink of an eye. This time of year, both parents and teachers face the same dilemma: Should high-ability kids stay busy with summer projects, courses, sports, camps, and travel...or should they be allowed to completely unplug with no…

Combined heat and power generation with a HCPV system at 2000 suns

DOE Office of Scientific and Technical Information (OSTI.GOV)

Paredes, Filippo; Montagnino, Fabio M.; Milone, Sergio

2015-09-28

This work shows the development of an innovative solar CHP system for the combined production of heat and power based upon HCPV modules working at the high concentration level of 2000 suns. The solar radiation is concentrated on commercial InGaP/InGaAs/Ge triple-junction solar cells designed for intensive work. The primary optics is a rectangular off-axis parabolic mirror while a secondary optic at the focus of the parabolic mirror is glued in optical contact with the cell. Each module consist of 2 axis tracker (Alt-Alt type) with 20 multijunction cells each one integrated with an active heat sink. The cell is connectedmore » to an active heat transfer system that allows to keep the cell at a high level of electrical efficiency (ηel > 30 %), bringing the heat transfer fluid (water and glycol) up to an output temperature of 90°C. Accordingly with the experimental data collected from the first 1 kWe prototype, the total amount of extracted thermal energy is above the 50% of the harvested solar radiation. That, in addition the electrical efficiency of the system contributes to reach an overall CHP efficiency of more than the 80%.« less

Dislocation gliding and cross-hatch morphology formation in AIII-BV epitaxial heterostructures

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kovalskiy, V. A., E-mail: kovalva@iptm.ru; Vergeles, P. S.; Eremenko, V. G.

2014-12-08

An approach for understanding the origin of cross-hatch pattern (CHP) on the surface of lattice mismatched GaMnAs/InGaAs samples grown on GaAs (001) substrates is developed. It is argued that the motion of threading dislocations in the (111) slip planes during the relaxation of InGaAs buffer layer is more complicated process and its features are similar to the ones of dislocation half-loops gliding in plastically deformed crystals. The heterostructures were characterized by atomic force microscopy and electron beam induced current (EBIC). Detailed EBIC experiments revealed contrast features, which cannot be accounted for by the electrical activity of misfit dislocations at themore » buffer/substrate interface. We attribute these features to specific extended defects (EDs) generated by moving threading dislocations in the partially relaxed InGaAs layers. We believe that the core topology, surface reconstruction, and elastic strains from these EDs accommodated in slip planes play an important role in the CHP formation. The study of such electrically active EDs will allow further understanding of degradation and changes in characteristics of quantum devices based on strained heterostructures.« less

The financial viability of an SOFC cogeneration system in single-family dwellings

NASA Astrophysics Data System (ADS)

Alanne, Kari; Saari, Arto; Ugursal, V. Ismet; Good, Joel

In the near future, fuel cell-based residential micro-CHP systems will compete with traditional methods of energy supply. A micro-CHP system may be considered viable if its incremental capital cost compared to its competitors equals to cumulated savings during a given period of time. A simplified model is developed in this study to estimate the operation of a residential solid oxide fuel cell (SOFC) system. A comparative assessment of the SOFC system vis-à-vis heating systems based on gas, oil and electricity is conducted using the simplified model for a single-family house located in Ottawa and Vancouver. The energy consumption of the house is estimated using the HOT2000 building simulation program. A financial analysis is carried out to evaluate the sensitivity of the maximum allowable capital cost with respect to system sizing, acceptable payback period, energy price and the electricity buyback strategy of an energy utility. Based on the financial analysis, small (1-2 kW e) SOFC systems seem to be feasible in the considered case. The present study shows also that an SOFC system is especially an alternative to heating systems based on oil and electrical furnaces.

Combined heat and power generation with a HCPV system at 2000 suns

NASA Astrophysics Data System (ADS)

Paredes, Filippo; Montagnino, Fabio M.; Salinari, Piero; Bonsignore, Gaetano; Milone, Sergio; Agnello, Simonpietro; Barbera, Marco; Gelardi, Franco M.; Sciortino, Luisa; Collura, Alfonso; Lo Cicero, Ugo; Cannas, Marco

2015-09-01

This work shows the development of an innovative solar CHP system for the combined production of heat and power based upon HCPV modules working at the high concentration level of 2000 suns. The solar radiation is concentrated on commercial InGaP/InGaAs/Ge triple-junction solar cells designed for intensive work. The primary optics is a rectangular off-axis parabolic mirror while a secondary optic at the focus of the parabolic mirror is glued in optical contact with the cell. Each module consist of 2 axis tracker (Alt-Alt type) with 20 multijunction cells each one integrated with an active heat sink. The cell is connected to an active heat transfer system that allows to keep the cell at a high level of electrical efficiency (ηel > 30 %), bringing the heat transfer fluid (water and glycol) up to an output temperature of 90°C. Accordingly with the experimental data collected from the first 1 kWe prototype, the total amount of extracted thermal energy is above the 50% of the harvested solar radiation. That, in addition the electrical efficiency of the system contributes to reach an overall CHP efficiency of more than the 80%.

Separation, preconcentration and inductively coupled plasma-mass spectrometric (ICP-MS) determination of thorium(IV), titanium(IV), iron(III), lead(II) and chromium(III) on 2-nitroso-1-naphthol impregnated MCI GEL CHP20P resin.

PubMed

Aydin, Funda Armagan; Soylak, Mustafa

2010-01-15

A simple and effective method is presented for the separation and preconcentration of Th(IV), Ti(IV), Fe(III), Pb(II) and Cr(III) by solid phase extraction on 2-nitroso-1-naphthol impregnated MCI GEL CHP20P resin prior to their inductively coupled plasma-mass spectrometric determinations. The influence of analytical parameters including pH of the aqueous solution, flow rates of sample and eluent solutions and sample volume on the quantitative recoveries of analyte ions was investigated. Matrix effects caused by the presence of alkali, earth alkali and some metal ions in the analyzed solutions were investigated. The presented solid phase extraction method was applied to BCR-144R Sewage Sludge (domestic origin), BCR-141R Calcareous Loam Soil, NIST 1568a Rice Flour and NIST 1577b Bovine Liver certified reference materials (CRMs) for the determination of analyte ions and the results were in good agreement with the certified values. The separation procedure presented was also applied to the various natural water samples collected from Turkey with satisfactory results.

Economic and environmental assessment of cellulosic ethanol production scenarios annexed to a typical sugar mill.

PubMed

Ali Mandegari, Mohsen; Farzad, Somayeh; Görgens, Johann F

2017-01-01

In this work different biorefinery scenarios were investigated, concerning the co-production of bioethanol and electricity from available lignocellulose at a typical sugar mill, as possible extensions to the current combustion of bagasse for steam and electricity production and burning trash on-filed. In scenario 1, the whole bagasse and brown leaves is utilized in a biorefinery and coal is burnt in the existing inefficient sugar mill boiler. Scenario 2 & 3 are assumed with a new centralized CHP unit without/with coal co-combustion, respectively. Also, through scenarios 4 & 5, the effect of water insoluble loading were studied. All scenarios provided energy for the sugarmill and the ethanol plant, with the export of surplus electricity. Economic analysis determined that scenario 1 was the most viable scenario due to less capital cost and economies-of scale. Based on Life Cycle Assessment (LCA) results, scenario 2 outperformed the other scenarios, while three scenarios showed lower contribution to environmental burdens than the current situation. Copyright © 2016 Elsevier Ltd. All rights reserved.

CFD Analysis of the Oscillating Flow within a Stirling Engine with an Additively Manufactured Foil Type Regenerator

NASA Astrophysics Data System (ADS)

Qiu, Songgang; Solomon, Laura

2017-11-01

The simplistic design, fuel independence, and robustness of Stirling convertors makes them the ideal choice for use in solar power and combined heat and power (CHP) applications. A lack of moving parts and the use of novel flexure bearings allows free-piston type Stirling engines to run in excess of ten years without degradation or maintenance. The key component to their overall efficiency is the regenerator. While a foil type regenerator outperforms a sintered random fiber regenerator, limitation in manufacturing and keeping uniform spacing between the foils has limited their overall use. However, with the advent of additive manufacturing, a robust foil type regenerator can be cheaply manufactured without traditional limitations. Currently, a CFD analysis of the oscillating internal flow within the novel design was conducted to evaluate the flow loses within the system. Particularly the pressure drop across the regenerator in comparison to a traditionally used random fiber regenerator. Additionally, the heat transfer and flow over the tubular heater hear was evaluated. The results of the investigation will be used to optimize the operation of the next generation of additively manufactured Stirling convertors. This research was supported by ARPA-E and West Virginia University.

Modeling of a thermally integrated 10 kWe planar solid oxide fuel cell system with anode offgas recycling and internal reforming by discretization in flow direction

NASA Astrophysics Data System (ADS)

Wahl, Stefanie; Segarra, Ana Gallet; Horstmann, Peter; Carré, Maxime; Bessler, Wolfgang G.; Lapicque, François; Friedrich, K. Andreas

2015-04-01

Combined heat and power production (CHP) based on solid oxide fuel cells (SOFC) is a very promising technology to achieve high electrical efficiency to cover power demand by decentralized production. This paper presents a dynamic quasi 2D model of an SOFC system which consists of stack and balance of plant and includes thermal coupling between the single components. The model is implemented in Modelica® and validated with experimental data for the stack UI-characteristic and the thermal behavior. The good agreement between experimental and simulation results demonstrates the validity of the model. Different operating conditions and system configurations are tested, increasing the net electrical efficiency to 57% by implementing an anode offgas recycle rate of 65%. A sensitivity analysis of characteristic values of the system like fuel utilization, oxygen-to-carbon ratio and electrical efficiency for different natural gas compositions is carried out. The result shows that a control strategy adapted to variable natural gas composition and its energy content should be developed in order to optimize the operation of the system.

Stationary Fuel Cell System Composite Data Products | Hydrogen and Fuel

Science.gov Websites

Capacity by Equipment Type CDP STAT 14, 10/21/15 Average Eligible Cost by Equipment Type, including Other Distributed Generation CDP STAT 15, 10/21/15 Average Eligible Cost for Biogas Sources CDP STAT 16, 10/21/15 Capacity and Eligible Cost (CHP Fuel Cells) CDP STAT 22, 10/21/15 Distribution of Eligible Cost with and

78 FR 16731 - Self-Regulatory Organizations; NYSE Arca, Inc.; Notice of Filing and Immediate Effectiveness of...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-18

... International Securities Exchange offers PRECISE TRADE as a means for users to enter orders and Chicago Board... users to develop their own internal front-end order entry systems and may provide savings to users in.../NASDAQOMXPHLXTools/PlatformViewer.asp?selectednode=chp%5F1%5F4&manual=%2Fnasdaqomxphlx%2Fphlx%2Fphlx%2Drulesbrd%2F...

Heat Pumps and Combined Heat and Power | Climate Neutral Research Campuses

Science.gov Websites

heat and power (CHP) systems on research campuses can reduce climate impact by 15% to 30% and yield a take advantage of large central heating plants and steam distribution systems that are available on climate impact. The material handling and combustion systems used for coal are often suitable for partial

Mathematical model for calculation of the heat-hydraulic modes of heating points of heat-supplying systems

NASA Astrophysics Data System (ADS)

Shalaginova, Z. I.

2016-03-01

The mathematical model and calculation method of the thermal-hydraulic modes of heat points, based on the theory of hydraulic circuits, being developed at the Melentiev Energy Systems Institute are presented. The redundant circuit of the heat point was developed, in which all possible connecting circuits (CC) of the heat engineering equipment and the places of possible installation of control valve were inserted. It allows simulating the operating modes both at central heat points (CHP) and individual heat points (IHP). The configuration of the desired circuit is carried out automatically by removing the unnecessary links. The following circuits connecting the heating systems (HS) are considered: the dependent circuit (direct and through mixing elevator) and independent one (through the heater). The following connecting circuits of the load of hot water supply (HWS) were considered: open CC (direct water pumping from pipelines of heat networks) and a closed CC with connecting the HWS heaters on single-level (serial and parallel) and two-level (sequential and combined) circuits. The following connecting circuits of the ventilation systems (VS) were also considered: dependent circuit and independent one through a common heat exchanger with HS load. In the heat points, water temperature regulators for the hot water supply and ventilation and flow regulators for the heating system, as well as to the inlet as a whole, are possible. According to the accepted decomposition, the model of the heat point is an integral part of the overall heat-hydraulic model of the heat-supplying system having intermediate control stages (CHP and IHP), which allows to consider the operating modes of the heat networks of different levels connected with each other through CHP as well as connected through IHP of consumers with various connecting circuits of local systems of heat consumption: heating, ventilation and hot water supply. The model is implemented in the Angara data-processing complex. An example of the multilevel calculation of the heat-hydraulic modes of main heat networks and those connected to them through central heat point distribution networks in Petropavlovsk-Kamchatskii is examined.

Analysis and Application of Microgrids

NASA Astrophysics Data System (ADS)

Yue, Lu

New trends of generating electricity locally and utilizing non-conventional or renewable energy sources have attracted increasing interests due to the gradual depletion of conventional fossil fuel energy sources. The new type of power generation is called Distributed Generation (DG) and the energy sources utilized by Distributed Generation are termed Distributed Energy Sources (DERs). With DGs embedded in the distribution networks, they evolve from passive distribution networks to active distribution networks enabling bidirectional power flows in the networks. Further incorporating flexible and intelligent controllers and employing future technologies, active distribution networks will turn to a Microgrid. A Microgrid is a small-scale, low voltage Combined with Heat and Power (CHP) supply network designed to supply electrical and heat loads for a small community. To further implement Microgrids, a sophisticated Microgrid Management System must be integrated. However, due to the fact that a Microgrid has multiple DERs integrated and is likely to be deregulated, the ability to perform real-time OPF and economic dispatch with fast speed advanced communication network is necessary. In this thesis, first, problems such as, power system modelling, power flow solving and power system optimization, are studied. Then, Distributed Generation and Microgrid are studied and reviewed, including a comprehensive review over current distributed generation technologies and Microgrid Management Systems, etc. Finally, a computer-based AC optimization method which minimizes the total transmission loss and generation cost of a Microgrid is proposed and a wireless communication scheme based on synchronized Code Division Multiple Access (sCDMA) is proposed. The algorithm is tested with a 6-bus power system and a 9-bus power system.

Hydrogen peroxide stabilization in one-dimensional flow columns.

PubMed

Schmidt, Jeremy T; Ahmad, Mushtaque; Teel, Amy L; Watts, Richard J

2011-09-25

Rapid hydrogen peroxide decomposition is the primary limitation of catalyzed H(2)O(2) propagations in situ chemical oxidation (CHP ISCO) remediation of the subsurface. Two stabilizers of hydrogen peroxide, citrate and phytate, were investigated for their effectiveness in one-dimensional columns of iron oxide-coated and manganese oxide-coated sand. Hydrogen peroxide (5%) with and without 25 mM citrate or phytate was applied to the columns and samples were collected at 8 ports spaced 13 cm apart. Citrate was not an effective stabilizer for hydrogen peroxide in iron-coated sand; however, phytate was highly effective, increasing hydrogen peroxide residuals two orders of magnitude over unstabilized hydrogen peroxide. Both citrate and phytate were effective stabilizers for manganese-coated sand, increasing hydrogen peroxide residuals by four-fold over unstabilized hydrogen peroxide. Phytate and citrate did not degrade and were not retarded in the sand columns; furthermore, the addition of the stabilizers increased column flow rates relative to unstabilized columns. These results demonstrate that citrate and phytate are effective stabilizers of hydrogen peroxide under the dynamic conditions of one-dimensional columns, and suggest that citrate and phytate can be added to hydrogen peroxide before injection to the subsurface as an effective means for increasing the radius of influence of CHP ISCO. Copyright © 2011. Published by Elsevier B.V.

Hydrogen peroxide stabilization in one-dimensional flow columns

NASA Astrophysics Data System (ADS)

Schmidt, Jeremy T.; Ahmad, Mushtaque; Teel, Amy L.; Watts, Richard J.

2011-09-01

Rapid hydrogen peroxide decomposition is the primary limitation of catalyzed H 2O 2 propagations in situ chemical oxidation (CHP ISCO) remediation of the subsurface. Two stabilizers of hydrogen peroxide, citrate and phytate, were investigated for their effectiveness in one-dimensional columns of iron oxide-coated and manganese oxide-coated sand. Hydrogen peroxide (5%) with and without 25 mM citrate or phytate was applied to the columns and samples were collected at 8 ports spaced 13 cm apart. Citrate was not an effective stabilizer for hydrogen peroxide in iron-coated sand; however, phytate was highly effective, increasing hydrogen peroxide residuals two orders of magnitude over unstabilized hydrogen peroxide. Both citrate and phytate were effective stabilizers for manganese-coated sand, increasing hydrogen peroxide residuals by four-fold over unstabilized hydrogen peroxide. Phytate and citrate did not degrade and were not retarded in the sand columns; furthermore, the addition of the stabilizers increased column flow rates relative to unstabilized columns. These results demonstrate that citrate and phytate are effective stabilizers of hydrogen peroxide under the dynamic conditions of one-dimensional columns, and suggest that citrate and phytate can be added to hydrogen peroxide before injection to the subsurface as an effective means for increasing the radius of influence of CHP ISCO.

A single-probe heat pulse method for estimating sap velocity in trees.

PubMed

López-Bernal, Álvaro; Testi, Luca; Villalobos, Francisco J

2017-10-01

Available sap flow methods are still far from being simple, cheap and reliable enough to be used beyond very specific research purposes. This study presents and tests a new single-probe heat pulse (SPHP) method for monitoring sap velocity in trees using a single-probe sensor, rather than the multi-probe arrangements used up to now. Based on the fundamental conduction-convection principles of heat transport in sapwood, convective velocity (V h ) is estimated from the temperature increase in the heater after the application of a heat pulse (ΔT). The method was validated against measurements performed with the compensation heat pulse (CHP) technique in field trees of six different species. To do so, a dedicated three-probe sensor capable of simultaneously applying both methods was produced and used. Experimental measurements in the six species showed an excellent agreement between SPHP and CHP outputs for moderate to high flow rates, confirming the applicability of the method. In relation to other sap flow methods, SPHP presents several significant advantages: it requires low power inputs, it uses technically simpler and potentially cheaper instrumentation, the physical damage to the tree is minimal and artefacts caused by incorrect probe spacing and alignment are removed. © 2017 The Authors. New Phytologist © 2017 New Phytologist Trust.

Northwest Region Clean Energy Application Center

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sjoding, David

2013-09-30

The main objective of the Northwest Clean Energy Application Center (NW CEAC) is to promote and support implementation of clean energy technologies. These technologies include combined heat and power (CHP), district energy, waste heat recovery with a primary focus on waste heat to power, and other related clean energy systems such as stationary fuel cell CHP systems. The northwest states include AK, ID, MT, OR, and WA. The key aim/outcome of the Center is to promote and support implementation of clean energy projects. Implemented projects result in a number of benefits including increased energy efficiency, renewable energy development (when usingmore » opportunity fuels), reduced carbon emissions, improved facility economics helping to preserve jobs, and reduced criteria pollutants calculated on an output-based emissions basis. Specific objectives performed by the NW CEAC fall within the following five broad promotion and support categories: 1) Center management and planning including database support; 2) Education and Outreach including plan development, website, target market workshops, and education/outreach materials development 3) Identification and provision of screening assessments & feasibility studies as funded by the facility or occasionally further support of Potential High Impact Projects; 4) Project implementation assistance/trouble shooting; and 5) Development of a supportive clean energy policy and initiative/financing framework.« less

Removal of sulphur-containing odorants from fuel gases for fuel cell-based combined heat and power applications

NASA Astrophysics Data System (ADS)

de Wild, P. J.; Nyqvist, R. G.; de Bruijn, F. A.; Stobbe, E. R.

Natural gas (NG) and liquefied petroleum gas (LPG) are important potential feedstocks for the production of hydrogen for fuel cell-based (e.g. proton exchange membrane fuel cells (PEMFC) or solid oxide fuel Cells (SOFC) combined heat and power (CHP) applications. To prevent detrimental effects on the (electro)catalysts in fuel cell-based combined heat and power installations (FC-CHP), sulphur removal from the feedstock is mandatory. An experimental bench-marking study of adsorbents has identified several candidates for the removal of sulphur containing odorants at low temperature. Among these adsorbents a new material has been discovered that offers an economically attractive means to remove TetraHydroThiophene (THT), the main European odorant, from natural gas at ambient temperature. The material is environmentally benign, easy to use and possesses good activity (residual sulphur levels below 20 ppbv) and capacity for the common odorant THT in natural gas. When compared to state-of-the-art metal-promoted active carbon the new material has a THT uptake capacity that is up to 10 times larger, depending on temperature and pressure. Promoted versions of the new material have shown potential for the removal of THT at higher temperatures and/or for the removal of other odorants such as mercaptans from natural gas or from LPG.

Final Technical Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Miller, Robert A.

2007-04-18

From September 1, 2002, to November 30, 2006, the Industrial Assessment Center (IAC) at the University of Illinois at Chicago (UIC) conducted over 120 industrial assessments across 19 different industry types in five different states. In the 1,000+ assessment recommendations written during the award, the UIC-IAC has written recommendations that, if implemented will save several millions of kilowatt-hours of electricity and several million British thermal units of natural gas annually. Additionally, the UIC-IAC has achieved an overall implementation rate in excess of 50%. During the overall span of the award period, the UIC-IAC has trained over 50 students, nearly 25%more » of which have remained in the energy field in some way after graduating from the IAC program. UIC-IAC students have received over $23,000 in scholarships in the last two years alone. During the course of the award, the UIC-IAC has made it a priority to incorporate ITP tools and technologies whenever possible. The ITP Best Practices tools have been used on several assessments and introduced to clients. DOE technologies are constantly compared against assessment clients to determine what technologies have reached the stage where they can effectively be introduced into industrial operations. The UIC-IAC has been involved in several projects for the Department of Energy (DOE), including energy assessments of Department of Defense bases and industrial facilities, the Plant Energy Profiler (PEP) tool assessment, and expanding the range of assessments to include large- energy users. Additionally, the UIC-IAC has forged a close relationship with the Midwest CHP Application Center, working to incorporate combined heat and power (CHP) and distributed generation (DG) technologies into industrial plants. The most recent project is the Save Energy Now (SEN) six- and 12-month follow-up surveys being conducted by UIC-IAC students. The SEN surveys are an effort for the DOE to determine the implementation rate of energy efficiency measures identified by Qualified System (QS) specialists throughout the nation. The UIC-IAC has also written several papers highlighting its work in the arena of energy efficiency. Currently, several UIC-IAC students have submitted a paper to the American Council for an Energy-Efficient Economy (ACEEE). This paper has been accepted by ACEEE and will be presented later in 2007.« less

Energy Engineering Analysis (EEA) program for Red River Army Depot, Texas. Executive summary. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

The objectives of this Energy Engineering Analysis (EEA) for RRAD were three fold: Develop a systematic plan of projects which will result in reducing energy consumption. Consider renewable energy sources with the objective of establishing an orderly procedure for reducing use of non-renewable energy sources. Determine the feasibility of Total Energy (TE), Selective Energy (SE), and Central Heating Plant (CHP) concepts using alternative fuels. In essence, an assessment of the entire energy picture at RRAD was undertaken. This report is a summary of that effort. RRAD was originally built during 1941 and 1942 as a reserve ordnance depot for themore » Army. Since then, the missions and activities at RRAD have broadened to the point that it is now one of the largest Army depots in the continental United States. Located just west of Texarkana, Texas, RRAD encompasses an area of approximately 19,886 acres. The primary missions at RRAD are general supply and maintenance of vital Army equipment and ordnance material. The supply activities constitute the stocking, distribution, storage and supply of general Army supplies for the central region of the United States. Supply of vehicles, ammunition and guided missiles from RRAD encompasses a much larger region. The maintenance and repair functions at RRAD consists of the overhaul, modification, conversion and repair of automotive equipment and combat vehicles, missile systems and components, armament, and ammunition. Approximately 5500 people are currently employed at RRAD to carry out its mission.« less

Determination of tropane alkaloids by heart cutting reversed phase - Strong cation exchange two dimensional liquid chromatography.

PubMed

Long, Zhen; Zhang, Yanhai; Gamache, Paul; Guo, Zhimou; Steiner, Frank; Du, Nana; Liu, Xiaoda; Jin, Yan; Liu, Xingguo; Liu, Lvye

2018-01-01

Current Chinese Pharmacopoeia (ChP) standards apply liquid extraction combined with one dimensional liquid chromatography (1DLC) method for determining alkaloids in herbal medicines. The complex pretreatments lead to a low analytical efficiency and possible component loss. In this study, a heart cutting reversed phase - strong cation exchange two dimensional liquid chromatography (RP - SCX 2DLC) approach was optimized for simultaneously quantifying tropane alkaloids (anisodine, scopolamine and hyoscyamine) in herbal medicines and herbal medicine tablets without further treatment of the filtered extract. The chromatographic conditions were systematically optimized in terms of column type, mobile phase composition and flow rate. To improve peak capacity and obtain symmetric peak shape of alkaloids, a polar group embedded C18 column combined with chaotropic salts was used in the first dimension. To remove the disturbance of non-alkaloids, achieve unique selectivity and acquire symmetric peak shape of alkaloids, an SCX column combined with phosphate buffer was used in the second dimension. Method validation was performed in terms of linearity, precision (0.54-0.82%), recovery (94.1-105.2%), limit of detection (LOD) and limit of quantification (LOQ) of the three analytes varied between 0.067-0.115mgL -1 and 0.195-0.268mgL -1 , respectively. The method demonstrated superiority over 1DLC method in respect of resolution (less alkaloid co-eluted), sample preparation (no pretreatment procedure) and transfer rate (minimum component loss). The optimized RP - SCX 2DLC approach was subsequently applied to quantify target alkaloids in five herbal medicines and herbal medicine tablets from three different manufactures. The results demonstrated that the developed heart cutting RP - SCX 2DLC approach represented a new, strategically significant methodology for the quality evaluation of tropane alkaloid in related herbal medicines that involve complex chemical matrix. Copyright © 2017. Published by Elsevier B.V.

Integrated Building Energy Systems Design Considering Storage Technologies

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stadler, Michael; Marnay, Chris; Siddiqui, Afzal

The addition of storage technologies such as flow batteries, conventional batteries, and heat storage can improve the economic, as well as environmental attraction of micro-generation systems (e.g., PV or fuel cells with or without CHP) and contribute to enhanced demand response. The interactions among PV, solar thermal, and storage systems can be complex, depending on the tariff structure, load profile, etc. In order to examine the impact of storage technologies on demand response and CO2 emissions, a microgrid's distributed energy resources (DER) adoption problem is formulated as a mixed-integer linear program that can pursue two strategies as its objective function.more » These two strategies are minimization of its annual energy costs or of its CO2 emissions. The problem is solved for a given test year at representative customer sites, e.g., nursing homes, to obtain not only the optimal investment portfolio, but also the optimal hourly operating schedules for the selected technologies. This paper focuses on analysis of storage technologies in micro-generation optimization on a building level, with example applications in New York State and California. It shows results from a two-year research projectperformed for the U.S. Department of Energy and ongoing work. Contrary to established expectations, our results indicate that PV and electric storage adoption compete rather than supplement each other considering the tariff structure and costs of electricity supply. The work shows that high electricity tariffs during on-peak hours are a significant driver for the adoption of electric storage technologies. To satisfy the site's objective of minimizing energy costs, the batteries have to be charged by grid power during off-peak hours instead of PV during on-peak hours. In contrast, we also show a CO2 minimization strategy where the common assumption that batteries can be charged by PV can be fulfilled at extraordinarily high energy costs for the site.« less

Central Heating Plant site characterization report, Marine Corps Combat Development Command, Quantico, Virginia

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1990-08-01

This report presents the methodology and results of a characterization of the operation and maintenance (O M) environment at the US Marine Corps (USMC) Quantico, Virginia, Central Heating Plant (CHP). This characterization is part of a program intended to provide the O M staff with a computerized artificial intelligence (AI) decision support system that will assist the plant staff in more efficient operation of their plant. 3 refs., 12 figs.

Combined Heat & Power Using the Infinia Concentrated Solar CHP PowerDish System

DTIC Science & Technology

2013-08-01

been due to a temperature induced reduction in magnetic field strength (inside the generator) that in turn can cause a generator over-stroke which can... Measurements and Sensors 34 Table 4: Results Summary Performance Objectives (same as Table 2) 38 Table 5: Building 9246 Energy Consumption vs...and Building Measurement Instrumentation P&ID 28 Figure 12: Building 9246 Radiant Heating and Hot Water Equipment 29 Figure 13: Coolant Flow

Development of a Low Cost 10kW Tubular SOFC Power System

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bessette, Norman; Litka, Anthony; Rawson, Jolyon

The DOE program funded from 2003 through early 2013 has brought the Acumentrics SOFC program from an early stage R&D program to an entry level commercial product offering. The development work started as one of the main core teams under the DOE Solid State Energy Conversion Alliance (SECA) program administered by the National Energy Technology Laboratory (NETL) of the DOE. During the first phase of the program, lasting approximately 3-4 years, a 5kW machine was designed, manufactured and tested against the specification developed by NETL. This unit was also shipped to NETL for independent verification testing which validated all ofmore » the results achieved while in the laboratory at Acumentrics. The Acumentrics unit passed all criteria established from operational stability, efficiency, and cost projections. Passing of the SECA Phase I test allowed the program to move into Phase II of the program. During this phase, the overall objective was to further refine the unit meeting a higher level of performance stability as well as further cost reductions. During the first year of this new phase, the NETL SECA program was refocused towards larger size units and operation on coal gasification due to the severe rise in natural gas prices and refocus on the US supply of indigenous coal. At this point, the program was shifted to the U.S. DOE’s Energy Efficiency and Renewable Energy (EERE) division located in Golden, Colorado. With this shift, the focus remained on smaller power units operational on gaseous fuels for a variety of applications including micro combined heat and power (mCHP). To achieve this goal, further enhancements in power, life expectancy and reductions in cost were necessary. The past 5 years have achieved these goals with machines that can now achieve over 40% electrical efficiency and field units that have now operated for close to a year and a half with minimal maintenance. The following report details not only the first phase while under the SECA program and the key achievements but also the results while under EERE’s leadership and the transition to an early commercial product offering.« less

Thermophilic anaerobic co-digestion of cattle manure with agro-wastes and energy crops: comparison of pilot and full scale experiences.

PubMed

Cavinato, C; Fatone, F; Bolzonella, D; Pavan, P

2010-01-01

The paper deals with the benefits coming from the application of a proper process temperature (55 degrees C) instead of a 'reduced' thermophilic range (47 degrees C), that is often applied in European anaerobic co-digestion plants. The experimental work has pointed out that biogas production improve from 0.45 to 0.62 m(3)/kg VS operating at proper thermophilic conditions. Moreover, also methane content was higher: from 52% to 61%. A general improvement in digester behaviour was clear also considering the stability parameters comparison (pH, ammonia, VFA content). The second part of the study takes into account the economic aspects related to the capital cost of anaerobic digestion treatment with a 1 MW co-generation unit fro heat and power production (CHP). Moreover, the economic balance was also carried out considering the anaerobic supernatants treatment for nitrogen removal. The simulation showed how a pay-back-time of 2.5 yr and between 3 and 5 yr respectively could be determined when the two options of anaerobic digestion only and together with the application of a nitrogen removal process were considered.

Optimization of biogas production using MEMS based near infrared inline-sensor

NASA Astrophysics Data System (ADS)

Saupe, Ray; Seider, Thomas; Stock, Volker; Kujawski, Olaf; Otto, Thomas; Gessner, Thomas

2013-03-01

Due to climate protection and increasing oil prices, renewable energy is becoming extremely important. Anaerobic digestion is a particular environmental and resource-saving way of heat and power production in biogas plants. These plants can be operated decentralized and independent of weather conditions and allow peak load operation. To maximize energy production, plants should be operated at a high efficiency. That means the entire installed power production capacity (e.g. CHP) and biogas production have to be used. However, current plant utilization in many areas is significantly lower, which is economically and environmentally inefficient, since the biochemical process responds to fluctuations in boundary conditions, e.g. mixing in the conditions and substrate composition. At present only a few easily accessible parameters such as fill level, flow rates and temperature are determined on-line. Monitoring of substrate composition occurs only sporadically with the help of laboratory methods. Direct acquisition of substrate composition combined with a smart control and regulation concept enables significant improvement in plant efficiency. This requires a compact, reliable and cost-efficient sensor. It is for this reason that a MEMS sensor system based on NIR spectroscopy has been developed. Requirements are high accuracy, which is the basic condition for exact chemometric evaluation of the sample as well as optimized MEMS design and packaging in order to work in poor environmental conditions. Another issue is sample presentation, which needs an exact adopted optical-mechanical system. In this paper, the development and application of a MEMS-based analyzer for biogas plants will be explained. The above mentioned problems and challenges will be discussed. Measurement results will be shown to demonstrate its performance.

Genetic and Environmental Pathways in Type 1 Diabetes Complications

DTIC Science & Technology

2010-09-26

setting? In the event that the project identifies a set of strongly predictive biomarkers an appropriate next step would be to approach TrialNet (see...http://www.diabetestrialnet.org). The TrialNet organization is a multi center study with the goal of identifying subjects for T1D prevention and...intervention trials. Children’s Hospital of Pittsburgh (CHP) is already acting as a clinical center for the TrialNet natural history study (Mahon et al

Documentation and User’s Manual for the Visual Detection Simulator (VDS) .

DTIC Science & Technology

1979-04-01

BUMEI) ZF51..524.004-2011 CONTROLLING OFFICE NAME AND ADDRESS 12 REPORT DATE Na al Mhedical Research and vel()chp ,ncIt Command .\\pril 1979 Nationa...Mediral Research and Development Command ZF51.524.004 --2011 Approved by ,3eleased by Ashton Graybiel, M.D. Captain R. E. Mitchel, MC, USN I Assistant for...Scientific Programs Commanrding Officer /April 1379 /- Naval Aerospace Medical Research Laboratory Naval Air Station Pensacola, Florida 32508 7

Federal Sector Renewable Energy Project Implementation: ’What’s Working and Why’

DTIC Science & Technology

2011-01-13

River Site biomass CHP (240,000 pph, 20 MW) 9 Oak Ridge National Laboratory biomass gasification • Hill AFB Landfill Gas to Energy Electrical...Photovoltaics (PV) � Concentrating Solar Power (CSP) (with storage) � Wind � Biomass power (waste-to-energy (WTE), wood feed stock combustion, etc...Projects examples ( biomass combustion) 9 NREL Renewable Fuel Heating Plant (6-8mmBtu/hr hot water boiler-displaces natural gas use) 9 Savannah

Conceptual study of a 250 kW planar SOFC system for CHP application

NASA Astrophysics Data System (ADS)

Fontell, E.; Kivisaari, T.; Christiansen, N.; Hansen, J.-B.; Pålsson, J.

In August 2002, Wärtsilä Corporation and Haldor Topsøe A/S entered into a co-operation agreement to start joint development program within the planar SOFC technology. The development program aims to bring to the market highly efficient, clean and cost competitive fuel cell systems with power outputs above 200 kW for distributed power generation with CHP and for marine applications. In this study, the product concept for a 250 kW natural gas-fuelled atmospheric SOFC plant has been studied. The process has been calculated and optimised for high electrical efficiency. In the calculations, system efficiencies more than 55-85% (electrical co-generation) have been reached. The necessary balance of plant (BoP) components have been identified and the concept for grid connection has been defined. The BoP includes fuel and air supply, anode re-circulation, start-up steam, purge gas, exhaust gas heat recovery, back-up power, power electronics and control system. Based on the analysed system and component information, a conceptual design and cost break down structure for the product have been made. The cost breakdown shows that the stack, system control and power electronics are the major cost factors, while the remaining BoP equipment stands for a minor share of the manufacturing cost. Finally, the feasibility of the SOFC plants has been compared to gas engines.

Microbiological Contamination at Workplaces in a Combined Heat and Power (CHP) Station Processing Plant Biomass

PubMed Central

Szulc, Justyna; Otlewska, Anna; Okrasa, Małgorzata; Majchrzycka, Katarzyna; Sulyok, Michael; Gutarowska, Beata

2017-01-01

The aim of the study was to evaluate the microbial contamination at a plant biomass processing thermal power station (CHP). We found 2.42 × 103 CFU/m3 of bacteria and 1.37 × 104 CFU/m3 of fungi in the air; 2.30 × 107 CFU/g of bacteria and 4.46 × 105 CFU/g of fungi in the biomass; and 1.61 × 102 CFU/cm2 bacteria and 2.39 × 101 CFU/cm2 fungi in filtering facepiece respirators (FFRs). Using culture methods, we found 8 genera of mesophilic bacteria and 7 of fungi in the air; 10 genera each of bacteria and fungi in the biomass; and 2 and 5, respectively, on the FFRs. Metagenomic analysis (Illumina MiSeq) revealed the presence of 46 bacterial and 5 fungal genera on the FFRs, including potential pathogens Candida tropicalis, Escherichia coli, Prevotella sp., Aspergillus sp., Penicillium sp.). The ability of microorganisms to create a biofilm on the FFRs was confirmed using scanning electron microscopy (SEM). We also identified secondary metabolites in the biomass and FFRs, including fumigaclavines, quinocitrinines, sterigmatocistin, and 3-nitropropionic acid, which may be toxic to humans. Due to the presence of potential pathogens and mycotoxins, the level of microbiological contamination at workplaces in CHPs should be monitored. PMID:28117709

Insights into plant biomass conversion from the genome of the anaerobic thermophilic bacterium Caldicellulosiruptor bescii DSM 6725

PubMed Central

Dam, Phuongan; Kataeva, Irina; Yang, Sung-Jae; Zhou, Fengfeng; Yin, Yanbin; Chou, Wenchi; Poole, Farris L.; Westpheling, Janet; Hettich, Robert; Giannone, Richard; Lewis, Derrick L.; Kelly, Robert; Gilbert, Harry J.; Henrissat, Bernard; Xu, Ying; Adams, Michael W. W.

2011-01-01

Caldicellulosiruptor bescii DSM 6725 utilizes various polysaccharides and grows efficiently on untreated high-lignin grasses and hardwood at an optimum temperature of ∼80°C. It is a promising anaerobic bacterium for studying high-temperature biomass conversion. Its genome contains 2666 protein-coding sequences organized into 1209 operons. Expression of 2196 genes (83%) was confirmed experimentally. At least 322 genes appear to have been obtained by lateral gene transfer (LGT). Putative functions were assigned to 364 conserved/hypothetical protein (C/HP) genes. The genome contains 171 and 88 genes related to carbohydrate transport and utilization, respectively. Growth on cellulose led to the up-regulation of 32 carbohydrate-active (CAZy), 61 sugar transport, 25 transcription factor and 234 C/HP genes. Some C/HPs were overproduced on cellulose or xylan, suggesting their involvement in polysaccharide conversion. A unique feature of the genome is enrichment with genes encoding multi-modular, multi-functional CAZy proteins organized into one large cluster, the products of which are proposed to act synergistically on different components of plant cell walls and to aid the ability of C. bescii to convert plant biomass. The high duplication of CAZy domains coupled with the ability to acquire foreign genes by LGT may have allowed the bacterium to rapidly adapt to changing plant biomass-rich environments. PMID:21227922

MET18 Deficiency Increases the Sensitivity of Yeast to Oxidative Stress and Shortens Replicative Lifespan by Inhibiting Catalase Activity.

PubMed

Chen, Ya-Qin; Liu, Xin-Guang; Zhao, Wei; Cui, Hongjing; Ruan, Jie; Yuan, Yuan; Tu, Zhiguang

2017-01-01

Yeast MET18 , a subunit of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery which is responsible for the maturation of Fe/S proteins, has been reported to participate in the oxidative stress response. However, the underlying molecular mechanisms remain unclear. In this study, we constructed a MET18/met18Δ heterozygous mutant yeast strain and found that MET18 deficiency in yeast cells impaired oxidative stress resistance as evidenced by increased sensitivity to hydrogen peroxide (H 2 O 2 ) and cumene hydroperoxide (CHP). Mechanistically, the mRNA levels of catalase A (CTA1) and catalase T (CTT1) as well as the total catalase activity were significantly reduced in MET18 -deficient cells. In contrast, overexpression of CTT1 or CTA1 in MET18 -deficient cells significantly increased the intracellular catalase activity and enhanced the resistance ability against H 2 O 2 and CHP. In addition, MET18 deficiency diminished the replicative capacity of yeast cells as evidenced by the shortened replicative lifespan, which can be restored by CTT1 overexpression, but not by CTA1 , in the MET18 -deficient cells. These results suggest that MET18 , in a catalase-dependent manner, plays an essential role in enhancing the resistance of yeast cells to oxidative stress and increasing the replicative capacity of yeast cells.

MET18 Deficiency Increases the Sensitivity of Yeast to Oxidative Stress and Shortens Replicative Lifespan by Inhibiting Catalase Activity

PubMed Central

Zhao, Wei; Cui, Hongjing

2017-01-01

Yeast MET18, a subunit of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery which is responsible for the maturation of Fe/S proteins, has been reported to participate in the oxidative stress response. However, the underlying molecular mechanisms remain unclear. In this study, we constructed a MET18/met18Δ heterozygous mutant yeast strain and found that MET18 deficiency in yeast cells impaired oxidative stress resistance as evidenced by increased sensitivity to hydrogen peroxide (H2O2) and cumene hydroperoxide (CHP). Mechanistically, the mRNA levels of catalase A (CTA1) and catalase T (CTT1) as well as the total catalase activity were significantly reduced in MET18-deficient cells. In contrast, overexpression of CTT1 or CTA1 in MET18-deficient cells significantly increased the intracellular catalase activity and enhanced the resistance ability against H2O2 and CHP. In addition, MET18 deficiency diminished the replicative capacity of yeast cells as evidenced by the shortened replicative lifespan, which can be restored by CTT1 overexpression, but not by CTA1, in the MET18-deficient cells. These results suggest that MET18, in a catalase-dependent manner, plays an essential role in enhancing the resistance of yeast cells to oxidative stress and increasing the replicative capacity of yeast cells. PMID:28828388

Effects of a polysaccharide nanogel-crosslinked membrane on wound healing.

PubMed

Maeda, Hiroki; Kobayashi, Hiroshi; Miyahara, Takayuki; Hashimoto, Yoshihide; Akiyoshi, Kazunari; Kasugai, Shohei

2017-04-01

Wound-dressing materials that promote wound healing while protecting wounds from infections are advantageous for clinical applications. Hence, we developed a cholesterol-bearing pullulan (CHP) nanogel that stimulated wound healing; however, it was mechanically weak and difficult to handle. Thus, the purpose of this study was to examine precisely the effects of a mechanically reinforced nanogel-crosslinked (NanoClik) membrane on wound healing. NanoClik was prepared by mixing a thiol-terminated polyethylene glycol solution and an acryloyl group-modified CHP nanogel solution. A thin silicone sheet membrane, which was combined with NanoClik, was prepared. The NanoClick membranes and both positive and negative control membranes (collagen combined with silicone membrane and silicone membrane alone, respectively) were tested in vivo using a dorsal skin defect rat model. The rate and extent of wound healing was compared between groups after 7 and 14 days of implantation. In the NanoClik membrane group, the wound area was significantly reduced and neoepithelialization was promoted, compared with that observed in the other groups. In addition, extension and accumulation of collagen fibers were evident in the NanoClik membrane group. The NanoClik membrane is a strong candidate for use as an effective and safe wound-dressing material. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 544-550, 2017. © 2015 Wiley Periodicals, Inc.

Testing the Birth Unit Design Spatial Evaluation Tool (BUDSET) in Australia: a pilot study.

PubMed

Foureur, Maralyn J; Leap, Nicky; Davis, Deborah L; Forbes, Ian F; Homer, Caroline E S

2011-01-01

To pilot test the Birth Unit Design Spatial Evaluation Tool (BUDSET) in an Australian maternity care setting to determine whether such an instrument can measure the optimality of different birth settings. Optimally designed spaces to give birth are likely to influence a woman's ability to experience physiologically normal labor and birth. This is important in the current industrialized environment, where increased caesarean section rates are causing concerns. The measurement of an optimal birth space is currently impossible, because there are limited tools available. A quantitative study was undertaken to pilot test the discriminant ability of the BUDSET in eight maternity units in New South Wales, Australia. Five auditors trained in the use of the BUDSET assessed the birth units using the BUDSET, which is based on 18 design principles and is divided into four domains (Fear Cascade, Facility, Aesthetics, and Support) with three to eight assessable items in each. Data were independently collected in eight birth units. Values for each of the domains were aggregated to provide an overall Optimality Score for each birth unit. A range of Optimality Scores was derived for each of the birth units (from 51 to 77 out of a possible 100 points). The BUDSET identified units with low-scoring domains. Essentially these were older units and conventional labor ward settings. The BUDSET provides a way to assess the optimality of birth units and determine which domain areas may need improvement. There is potential for improvements to existing birth spaces, and considerable improvement can be made with simple low-cost modifications. Further research is needed to validate the tool.

A Modified Penalty Parameter Approach for Optimal Estimation of UH with Simultaneous Estimation of Infiltration Parameters

NASA Astrophysics Data System (ADS)

Bhattacharjya, Rajib Kumar

2018-05-01

The unit hydrograph and the infiltration parameters of a watershed can be obtained from observed rainfall-runoff data by using inverse optimization technique. This is a two-stage optimization problem. In the first stage, the infiltration parameters are obtained and the unit hydrograph ordinates are estimated in the second stage. In order to combine this two-stage method into a single stage one, a modified penalty parameter approach is proposed for converting the constrained optimization problem to an unconstrained one. The proposed approach is designed in such a way that the model initially obtains the infiltration parameters and then searches the optimal unit hydrograph ordinates. The optimization model is solved using Genetic Algorithms. A reduction factor is used in the penalty parameter approach so that the obtained optimal infiltration parameters are not destroyed during subsequent generation of genetic algorithms, required for searching optimal unit hydrograph ordinates. The performance of the proposed methodology is evaluated by using two example problems. The evaluation shows that the model is superior, simple in concept and also has the potential for field application.

Evaluation of a Cooling Headpiece during Work in a Hot Environment

DTIC Science & Technology

1987-10-01

Press, 1960. 3. Brown, GA, and Willims, GM: The effects of head cooling on deep body temperature and thermal comfort in man. Aviat. Space & Environ...1971. 18. Williams, BA, and Shitzer, A,. A modular liquid-cooled helmet for thermal comfort . Aerospace Med. 45(g):1030-1036, 1974. 11J i. E Appendix A...to physiological benefits, soldier comfort and performance mey I also be enhanced by the CHP. Scalp temperature may be a factor in whole body thermal

Analysis of results obtained using the automatic chemical control of the quality of the water heat carrier in the drum boiler of the Ivanovo CHP-3 power plant

NASA Astrophysics Data System (ADS)

Larin, A. B.; Kolegov, A. V.

2012-10-01

Results of industrial tests of the new method used for the automatic chemical control of the quality of boiler water of the drum-type power boiler ( P d = 13.8 MPa) are described. The possibility of using an H-cationite column for measuring the electric conductivity of an H-cationized sample of boiler water over a long period of time is shown.

Solar Simulation Laboratory Description and Manual.

DTIC Science & Technology

1985-06-01

2000 was sent back to Cyborg Corp. three times over a five month period for repairs. The solar lab is presently using a loaner from Cyborg Corp. The IBM...PC/XT is connected to the ISAAC 2000 by a RS232 connection. All programs were written in advanced basic ("BASICA"). BASICA was used because Cyborg ...2067 CH/P Temperature.Control Bath TechnicalManual, November. 1980. A 30. Cyborg Corporation, Version 1.2, IS..AC.....Co..mpiut.er.liz e.d Data

Directional Convexity and Finite Optimality Conditions.

DTIC Science & Technology

1984-03-01

system, Necessary Conditions for optimality. Work Unit Number 5 (Optimization and Large Scale Systems) *Istituto di Matematica Applicata, Universita...that R(T) is convex would then imply x(u,T) e int R(T). Cletituto di Matematica Applicata, Universita di Padova, 35100 ITALY. Sponsored by the United

[Diagnosis and the technology for optimizing the medical support of a troop unit].

PubMed

Korshever, N G; Polkovov, S V; Lavrinenko, O V; Krupnov, P A; Anastasov, K N

2000-05-01

The work is devoted to investigation of the system of military unit medical support with the use of principles and states of organizational diagnosis; development of the method allowing to assess its functional activity; and determination of optimization trends. Basing on the conducted organizational diagnosis and expert inquiry the informative criteria were determined which characterize the stages of functioning of the military unit medical support system. To evaluate the success of military unit medical support the complex multi-criteria pattern was developed and algorithm of this process optimization was substantiated. Using the results obtained, particularly realization of principles and states of decision taking theory in machine program it is possible to solve more complex problem of comparison between any number of military units: to dispose them according to priority decrease; to select the programmed number of the best and worst; to determine the trends of activity optimization in corresponding medical service personnel.

Tissue reaction to a triantibiotic paste used for endodontic tissue self-regeneration of nonvital immature permanent teeth.

PubMed

Gomes-Filho, João Eduardo; Duarte, Paulo Carvalho Tobias; de Oliveira, Claudiel Batista; Watanabe, Simone; Lodi, Carolina Simonetti; Cintra, Luciano Tavares Ângelo; Bernabé, Pedro Felício Estrada

2012-01-01

The endodontic regenerative procedure (ERP), which is an alternative to calcium hydroxide-induced apexification, involves the use of a triple antibiotic paste (TAP) as a dressing material. The aim of this study was to evaluate the response of rat subcutaneous tissue to implanted polyethylene tubes that were filled with TAP or calcium hydroxide. Thirty rats received 2 individual implants of polyethylene tubes filled with TAP or calcium hydroxide paste (CHP) and another empty tube as a control. Thirty additional rats received 2 individual implants consisting of polyethylene tubes filled with dressing material carriers (macrogol and propylene glycol) and a sham procedure. After 7, 15, 30, 60, and 90 days, 12 animals were euthanized, and the tubes and surrounding tissue were removed and processed for histology by using glycol methacrylate and stained with hematoxylin and eosin. The histological score ranged from 0 to 3 depending on the content of inflammatory cells; the fibrous capsule was considered thin or thick, and necrosis and calcification were recorded as present or absent. The results were analyzed using the Kruskal-Wallis test. Both dressing materials induced moderate reactions at 7 and 15 days. These reactions were similar to the control (P > .05) and reduced in intensity (to mild) from day 30 onward (P > .05). The carriers did not interfere with the reaction of the dressing materials. TAP and CHP were biocompatible over the different experimental periods examined. Copyright © 2012 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.

Vascular Accesses for Haemodialysis in the Upper Arm Cause Greater Reduction in the Carotid-Brachial Stiffness than Those in the Forearm: Study of Gender Differences

PubMed Central

Bia, Daniel; Cabrera-Fischer, Edmundo I.; Zócalo, Yanina; Galli, Cintia; Graf, Sebastián; Valtuille, Rodolfo; Pérez-Cámpos, Héctor; Saldías, María; Álvarez, Inés; Armentano, Ricardo L.

2012-01-01

Purpose. To evaluate in chronically haemodialysed patients (CHPs), if: (1) the vascular access (VA) position (upper arm or forearm) is associated with differential changes in upper limb arterial stiffness; (2) differences in arterial stiffness exist between genders associated with the VA; (3) the vascular substitute (VS) of choice, in biomechanical terms, depends on the previous VA location and CHP gender. Methods. 38 CHPs (18 males; VA in upper arm: 18) were studied. Left and right carotid-brachial pulse wave velocity (PWVc-b) was measured. In in vitro studies, PWV was obtained in ePTFE prostheses and in several arterial and venous homografts obtained from donors. The biomechanical mismatch (BM) between CHP native vessel (NV) and VS was calculated. Results/Conclusions. PWVc-b in upper limbs with VA was lower than in the intact contralateral limbs (P < 0.05), and differences were higher (P < 0.05) when the VA was performed in the upper arm. Differences between PWVc-b in upper limbs with VA (in the upper arm) with respect to intact upper limbs were higher (P < 0.05) in males. Independently of the region in which the VA was performed, the homograft that ensured the minimal BM was the brachial artery. The BM was highly dependent on gender and the location in the upper limb in which the VA was performed. PMID:22567282

Maternal high-protein diet during pregnancy, but not during suckling, induced altered expression of an increasing number of hepatic genes in adult mouse offspring.

PubMed

Vanselow, Jens; Kucia, Marzena; Langhammer, Martina; Koczan, Dirk; Metges, Cornelia C

2016-04-01

Indirect effects of a high-protein maternal diet are not well understood. In this study, we analyzed short-term and sustainable effects of a prenatal versus early postnatal maternal high-protein diet on growth and hepatic gene expression in mouse offspring. Dams were exposed to an isoenergetic high-protein (HP, 40 % w/w) diet during pregnancy or lactation. Growth and hepatic expression profiles of male offspring were evaluated directly after weaning and 150 days after birth. Offspring from two dietary groups, high-protein diet during pregnancy and control diet during lactation (HPC), and control diet during pregnancy and high-protein diet during lactation (CHP), were compared with offspring (CC) from control-fed dams. Maternal CHP treatment was associated with sustained offspring growth retardation, but decreased numbers of affected hepatic genes in adults compared to weanlings. In contrast, offspring of the HPC group did not show persistent effects on growth parameters, but the number of affected hepatic genes was even increased at adult age. In both dietary groups, however, only a small subset of genes was affected in weanlings as well as in adults. We conclude that (1) prenatal and early postnatal maternal HP diet caused persistent, but (2) different effects and partially complementary trends on growth characteristics and on the hepatic transcriptome and associated pathways and that (3) only a small number of genes and associated upstream regulators might be involved in passing early diet-induced imprints to adulthood.

Intermediate temperature solid oxide fuel cell based on lanthanum gallate electrolyte

NASA Astrophysics Data System (ADS)

Inagaki, Toru; Nishiwaki, Futoshi; Yamasaki, Satoru; Akbay, Taner; Hosoi, Kei

The Kansai Electric Power Co. Inc. (KEPCO) and Mitsubishi Materials Corporation (MMC) have been developing intermediate temperature solid oxide fuel cells (IT-SOFCs) which are operable at a temperature range between 600 and 800 °C. There are some significant features in IT-SOFC of KEPCO-MMC: (1) highly conductive lanthanum gallate-based oxide is adopted as an electrolyte to realize high-performance disk-type electrolyte-supported cells; (2) the cell-stacks with seal-less structure using metallic separators allow residual fuel to burn around the stack and the combustion heat is utilized for thermally self-sustainable operation; (3) the separators have flexible arms by which separate compressive forces can be applied for manifold parts and interconnection parts. We are currently participating in the project by New Energy and Industrial Technology Development Organization (NEDO) to develop 10 kW-class combined heat and power (CHP) systems. In FY2006, a 10 kW-class module was developed, with which the electrical efficiency of 50%HHV was obtained based on DC 12.6 kW. In the first quarter of FY2007, the 10 kW-class CHP system using the module gave the electrical efficiency of 41%HHV on AC 10 kW and the overall efficiency of 82%HHV when exhaust heat was recovered as 60 °C hot water. Currently, the operation has been accumulated for about 2500 h to evaluate the long-term stability of the system.

The Cost-Effectiveness of Continuous Erythropoiesis Receptor Activator Once Monthly versus Epoetin Thrice Weekly for Anaemia Management in Chronic Haemodialysis Patients

PubMed Central

Maoujoud, Omar; Ahid, Samir; Dkhissi, Hocein; Oualim, Zouhair; Cherrah, Yahia

2015-01-01

Introduction. The aim of this study was to compare the cost-effectiveness of continuous erythropoietin receptor activator (CERA) once monthly to epoetin beta (EpoB) thrice weekly to maintain haemoglobin (Hb) within the range 10.5–12 g/dL. Methods. Prospective cohort study and cost-effectiveness analysis. Chronic haemodialysis patients (CHP), being treated with EpoB, were selected for two periods of follow-up: period 1, maintaining prior treatment with EpoB, and period 2, conversion to CERA once monthly. Hb concentrations and costs were measured monthly. Health care payer perspective for one year was adopted. Results. 75 CHP completed the study, with a mean age of 52.9 ± 14.3 years. Baseline Hb was 11.14 ± 1.18 g/dL in EpoB phase and 11.46 ± 0.79 g/dL in CERA phase; we observed a significant increase in the proportion of patients successfully treated (Hb within the recommended range), 65.3% versus 70.7%, p: 0.008, and in the average effectiveness by 4% (0.55 versus 0.59). Average cost-effectiveness ratios were 6013.86 and 5173.64$, with an ICER CERA to EpoB at −6457.5$. Conclusion. Our health economic evaluation of ESA use in haemodialysis patients suggests that the use of CERA is cost-effective compared with EpoB. PMID:26843983

Mathematical model of parking space unit for triangular parking area

NASA Astrophysics Data System (ADS)

Syahrini, Intan; Sundari, Teti; Iskandar, Taufiq; Halfiani, Vera; Munzir, Said; Ramli, Marwan

2018-01-01

Parking space unit (PSU) is an effective measure for the area size of a vehicle, including the free space and the width of the door opening of the vehicle (car). This article discusses a mathematical model for parking space of vehicles in triangular shape area. An optimization model for triangular parking lot is developed. Integer Linear Programming (ILP) method is used to determine the maximum number of the PSU. The triangular parking lot is in isosceles and equilateral triangles shape and implements four possible rows and five possible angles for each field. The vehicles which are considered are cars and motorcycles. The results show that the isosceles triangular parking area has 218 units of optimal PSU, which are 84 units of PSU for cars and 134 units of PSU for motorcycles. Equilateral triangular parking area has 688 units of optimal PSU, which are 175 units of PSU for cars and 513 units of PSU for motorcycles.

Experimental broadband absorption enhancement in silicon nanohole structures with optimized complex unit cells.

PubMed

Lin, Chenxi; Martínez, Luis Javier; Povinelli, Michelle L

2013-09-09

We design silicon membranes with nanohole structures with optimized complex unit cells that maximize broadband absorption. We fabricate the optimized design and measure the optical absorption. We demonstrate an experimental broadband absorption about 3.5 times higher than an equally-thick thin film.

Optimal load scheduling in commercial and residential microgrids

NASA Astrophysics Data System (ADS)

Ganji Tanha, Mohammad Mahdi

Residential and commercial electricity customers use more than two third of the total energy consumed in the United States, representing a significant resource of demand response. Price-based demand response, which is in response to changes in electricity prices, represents the adjustments in load through optimal load scheduling (OLS). In this study, an efficient model for OLS is developed for residential and commercial microgrids which include aggregated loads in single-units and communal loads. Single unit loads which include fixed, adjustable and shiftable loads are controllable by the unit occupants. Communal loads which include pool pumps, elevators and central heating/cooling systems are shared among the units. In order to optimally schedule residential and commercial loads, a community-based optimal load scheduling (CBOLS) is proposed in this thesis. The CBOLS schedule considers hourly market prices, occupants' comfort level, and microgrid operation constraints. The CBOLS' objective in residential and commercial microgrids is the constrained minimization of the total cost of supplying the aggregator load, defined as the microgrid load minus the microgrid generation. This problem is represented by a large-scale mixed-integer optimization for supplying single-unit and communal loads. The Lagrangian relaxation methodology is used to relax the linking communal load constraint and decompose the independent single-unit functions into subproblems which can be solved in parallel. The optimal solution is acceptable if the aggregator load limit and the duality gap are within the bounds. If any of the proposed criteria is not satisfied, the Lagrangian multiplier will be updated and a new optimal load schedule will be regenerated until both constraints are satisfied. The proposed method is applied to several case studies and the results are presented for the Galvin Center load on the 16th floor of the IIT Tower in Chicago.

Hydrodynamics and mass transfer deaeration of water on thermal power plants when used natural gas as a desorbing agent

NASA Astrophysics Data System (ADS)

Sharapov, V. I.; Kudryavtseva, E. V.

2017-11-01

The technology of low-temperature deaeration of water in thermal power plants was developed. It is proposed to use natural gas supplied to the furnace as desorbing agent in the deaerator instead steam or superheated water. Natural gas has low, often - negative temperature after reducing installs. At the same time, it contains virtually no corrosive gases, oxygen and carbon dioxide, thereby successfully may be used as a stripping agent in water deaeration. The calculation of the energy efficiency of the technology for a typical unit of CHP has shown that achieved a significant annual saving of fuel equivalent in the transition from the traditional method of deaeration of water in the low temperature deaeration. Hydrodynamic and mass transfer indicators were determined for the deaerator thermal power plants using as stripping medium natural gas supplied to the boiler burners. Theoretically required amount and the real specific consumption of natural gas were estimated for deaeration of water standard quality. The calculation of the hydrodynamic characteristics was presented for jet-bubbling atmospheric deaerator with undescended perforated plate when operating on natural gas. The calculation shows the possibility of using commercially available atmospheric deaerators for the application of the new low-temperature water deaeration technology.

On-line experimental validation of a model-based diagnostic algorithm dedicated to a solid oxide fuel cell system

NASA Astrophysics Data System (ADS)

Polverino, Pierpaolo; Esposito, Angelo; Pianese, Cesare; Ludwig, Bastian; Iwanschitz, Boris; Mai, Andreas

2016-02-01

In the current energetic scenario, Solid Oxide Fuel Cells (SOFCs) exhibit appealing features which make them suitable for environmental-friendly power production, especially for stationary applications. An example is represented by micro-combined heat and power (μ-CHP) generation units based on SOFC stacks, which are able to produce electric and thermal power with high efficiency and low pollutant and greenhouse gases emissions. However, the main limitations to their diffusion into the mass market consist in high maintenance and production costs and short lifetime. To improve these aspects, the current research activity focuses on the development of robust and generalizable diagnostic techniques, aimed at detecting and isolating faults within the entire system (i.e. SOFC stack and balance of plant). Coupled with appropriate recovery strategies, diagnosis can prevent undesired system shutdowns during faulty conditions, with consequent lifetime increase and maintenance costs reduction. This paper deals with the on-line experimental validation of a model-based diagnostic algorithm applied to a pre-commercial SOFC system. The proposed algorithm exploits a Fault Signature Matrix based on a Fault Tree Analysis and improved through fault simulations. The algorithm is characterized on the considered system and it is validated by means of experimental induction of faulty states in controlled conditions.

Energy Efficiency and Importance of Renewable Energy Sources in Latvia

NASA Astrophysics Data System (ADS)

Skapare, I.; Kreslins, A.

2007-10-01

The main goal of Latvian energy policy is to ensure safe and environmentally friendly long-term energy supply at cost-effective prices, contributing to enhance competitiveness, and to ensure safe energy transit. The Latvian Parliament approved an Energy Efficiency Strategy in 2000. Its objective is to decrease energy consumption per unit of GDP by 25% by 2010. Awareness raising, implementation of standards and economic incentives for self financing are the main instruments to increase energy efficiency, mentioned in the strategy. Latvia, as many other European Union member states, is dependent on the import of primary energy resources. The Latvian Renewable Energy strategy is still under development. The only recent study on RES was developed in the framework of a PHARE program in year 2000: "Renewable energy resource program", where three main objectives for a future RES strategy were proposed: 1. To increase the use of wood waste and low value wood and forest residues. 2. To improve efficiency of combustion technologies and to replace outdated plants. 3. To increase the use of renewables in Combined Heat and Power plants (CHP). Through the Renewable Energy and Energy Efficiency Partnership, partners will develop a set of new shared activities, and coordinate and strengthen existing efforts in this area.

Rhombicuboctahedron unit cell based scaffolds for bone regeneration: geometry optimization with a mechanobiology - driven algorithm.

PubMed

Boccaccio, Antonio; Fiorentino, Michele; Uva, Antonio E; Laghetti, Luca N; Monno, Giuseppe

2018-02-01

In a context more and more oriented towards customized medical solutions, we propose a mechanobiology-driven algorithm to determine the optimal geometry of scaffolds for bone regeneration that is the most suited to specific boundary and loading conditions. In spite of the huge number of articles investigating different unit cells for porous biomaterials, no studies are reported in the literature that optimize the geometric parameters of such unit cells based on mechanobiological criteria. Parametric finite element models of scaffolds with rhombicuboctahedron unit cell were developed and incorporated into an optimization algorithm that combines them with a computational mechanobiological model. The algorithm perturbs iteratively the geometry of the unit cell until the best scaffold geometry is identified, i.e. the geometry that allows to maximize the formation of bone. Performances of scaffolds with rhombicuboctahedron unit cell were compared with those of other scaffolds with hexahedron unit cells. We found that scaffolds with rhombicuboctahedron unit cell are particularly suited for supporting medium-low loads, while, for higher loads, scaffolds with hexahedron unit cells are preferable. The proposed algorithm can guide the orthopaedic/surgeon in the choice of the best scaffold to be implanted in a patient-specific anatomic region. Copyright © 2017 Elsevier B.V. All rights reserved.

Probability distribution functions for unit hydrographs with optimization using genetic algorithm

NASA Astrophysics Data System (ADS)

Ghorbani, Mohammad Ali; Singh, Vijay P.; Sivakumar, Bellie; H. Kashani, Mahsa; Atre, Atul Arvind; Asadi, Hakimeh

2017-05-01

A unit hydrograph (UH) of a watershed may be viewed as the unit pulse response function of a linear system. In recent years, the use of probability distribution functions (pdfs) for determining a UH has received much attention. In this study, a nonlinear optimization model is developed to transmute a UH into a pdf. The potential of six popular pdfs, namely two-parameter gamma, two-parameter Gumbel, two-parameter log-normal, two-parameter normal, three-parameter Pearson distribution, and two-parameter Weibull is tested on data from the Lighvan catchment in Iran. The probability distribution parameters are determined using the nonlinear least squares optimization method in two ways: (1) optimization by programming in Mathematica; and (2) optimization by applying genetic algorithm. The results are compared with those obtained by the traditional linear least squares method. The results show comparable capability and performance of two nonlinear methods. The gamma and Pearson distributions are the most successful models in preserving the rising and recession limbs of the unit hydographs. The log-normal distribution has a high ability in predicting both the peak flow and time to peak of the unit hydrograph. The nonlinear optimization method does not outperform the linear least squares method in determining the UH (especially for excess rainfall of one pulse), but is comparable.

Health plan joins with physical therapy facility to manage back and neck pain.

PubMed

Tomlinson, Charles M; Gray, Chad; Kane, Tom

2008-06-01

Twenty-five billion dollars is spent each year on the medical care of back pain, and $50 billion is lost in productivity. Primary care physicians might have difficulty providing thorough counseling and treatment to their patients about the condition. In 2006, Capital Health Plan (CHP) partnered with Orthopedic and Sports Physical Therapy, which employed the mechanical diagnosis and therapy (MDT) technique. After undergoing this technique, members experienced a 79% improvement in pain scores and a 54% improvement in function scores, compared to when they started treatment.

Demonstration of Next-Generation PEM CHP Systems for Global Markets Using PBI Membrane Technology

DOE Office of Scientific and Technical Information (OSTI.GOV)

Vogel, John; Fritz Intwala, Katrina

Plug Power and BASF have conducted eight years of development work prior to this project, demonstrating the potential of PBI membranes to exceed many DOE technical targets. This project consisted of; 1.The development of a worldwide system architecture; 2.Stack and balance of plant module development; 3.Development of an improved, lower cost MEA electrode; 4.Receipt of an improved MEA from the EU consortium; 5.Integration of modules into a system; and 6.Delivery of system to EU consortium for additional integration of technologies and testing.

Effect of Food, Diet and Nutrition on Military Readiness and Preparedness of Army Personnel and Dependents In a Peacetime Environment

DTIC Science & Technology

1992-08-15

with carbohydrate (C), protein (P), and fat (F) diets . This led us to investigate whether intraventricularly administered CHP may affect caloric intake...AD-A260 006 ,,ill~ II iII IIU !1 1,11 II CONTRACT NO.: DAMD17-88-Z-8023 TITLE: EFFECT OF FOOD, DIET AND NUTRITION ON MILITARY READINESS AND...NO. NO. WM2- NO. ACCESSION NO. 63002A 53002D819 AI 150 11. TITLE (Include Securrty Clasificarion) Effect of Food, Diet and Nutrition on Military

Influence of live tularemia vaccine on chemical mutagenesis in white rats

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zil'fyan, V.N.; Nersesyan, A.K.; Kumkumadzhyan, V.A.

1986-03-01

The influence of a single cutaneous immunization of live dry tularemia vaccine (TV) on mutagenesis induced by cyclophosphamide (CP), methyl nitrosourea (MNU), benzopyrene(BP), chloroprene (ChP), and 1,2,3,4-tetrachlorobutane (TCB) is studied for the first time on rats of the Wistar line. It is established that in rats immunized with TV, significant reduction in number of aberrant myelokaryocytes is noted on the 15th day after vaccination as compared to unimmunized animals which received the mutagens indicated. Possible mechanisms of the effect obtained are discussed.

METAS New Time Scale Generation System - A Progress Report

DTIC Science & Technology

2007-01-01

and a TWSTFT station are used for remote T&F comparisons. The GPS TAI link is driven by one of the atomic clocks defined as the REF clock...UTC(CH.P) paper clock TA(CH.P) paper clock TWSTFT link GPS link CH00 WAB1 H-maser 1-PPS H-maser 1-PPS REF 1-PPS 5-MHz from all clocks UTC(CH.R) 1-PPS...lost, the only consequence would be a transient of UTC (CH.P), which can be corrected by a subsequent steering. The GPS and TWSTFT links can be

Intelligence Aid for Evaluating Enemy Courses of Action (ENCOA): Guide for Manual and HP41-C/HP41-CV Calculator Procedures

DTIC Science & Technology

1982-06-01

for use by intellignece analysts in field operations, tactical training, and academic DD I 1473wu EDITION OF f OV 65 IS OBSOLETE UNCLASSIFIED SECURITY...Category Factor t.i Fields of fire 1.2 Cover and concealment 1.0 TERRAIN FACTORS 1. oblt 1.4 Seize/deny key terrain 1.5 Observation 1.o Natural/ artificial ...provisions of terrain. - 1.6 Exploits or accommodates natural and artificial obstacles. 2.0 U.S. FORCE FACTORS *: As related to mission accomplishment

Design of shared unit-dose drug distribution network using multi-level particle swarm optimization.

PubMed

Chen, Linjie; Monteiro, Thibaud; Wang, Tao; Marcon, Eric

2018-03-01

Unit-dose drug distribution systems provide optimal choices in terms of medication security and efficiency for organizing the drug-use process in large hospitals. As small hospitals have to share such automatic systems for economic reasons, the structure of their logistic organization becomes a very sensitive issue. In the research reported here, we develop a generalized multi-level optimization method - multi-level particle swarm optimization (MLPSO) - to design a shared unit-dose drug distribution network. Structurally, the problem studied can be considered as a type of capacitated location-routing problem (CLRP) with new constraints related to specific production planning. This kind of problem implies that a multi-level optimization should be performed in order to minimize logistic operating costs. Our results show that with the proposed algorithm, a more suitable modeling framework, as well as computational time savings and better optimization performance are obtained than that reported in the literature on this subject.

Smart house-based optimal operation of thermal unit commitment for a smart grid considering transmission constraints

NASA Astrophysics Data System (ADS)

Howlader, Harun Or Rashid; Matayoshi, Hidehito; Noorzad, Ahmad Samim; Muarapaz, Cirio Celestino; Senjyu, Tomonobu

2018-05-01

This paper presents a smart house-based power system for thermal unit commitment programme. The proposed power system consists of smart houses, renewable energy plants and conventional thermal units. The transmission constraints are considered for the proposed system. The generated power of the large capacity renewable energy plant leads to the violated transmission constraints in the thermal unit commitment programme, therefore, the transmission constraint should be considered. This paper focuses on the optimal operation of the thermal units incorporated with controllable loads such as Electrical Vehicle and Heat Pump water heater of the smart houses. The proposed method is compared with the power flow in thermal units operation without controllable loads and the optimal operation without the transmission constraints. Simulation results show the validation of the proposed method.

Lifelong Optimization

DTIC Science & Technology

2015-04-13

cope with dynamic, online optimisation problems with uncertainty, we developed some powerful and sophisticated techniques for learning heuristics...NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) National ICT Australia United NICTA, Locked Bag 6016 Kensington...ABSTRACT Optimization solvers should learn to improve their performance over time. By learning both during the course of solving an optimization

Life Cycle Assessment of Mixed Municipal Solid Waste: Multi-input versus multi-output perspective.

PubMed

Fiorentino, G; Ripa, M; Protano, G; Hornsby, C; Ulgiati, S

2015-12-01

This paper analyses four strategies for managing the Mixed Municipal Solid Waste (MMSW) in terms of their environmental impacts and potential advantages by means of Life Cycle Assessment (LCA) methodology. To this aim, both a multi-input and a multi-output approach are applied to evaluate the effect of these perspectives on selected impact categories. The analyzed management options include direct landfilling with energy recovery (S-1), Mechanical-Biological Treatment (MBT) followed by Waste-to-Energy (WtE) conversion (S-2), a combination of an innovative MBT/MARSS (Material Advanced Recovery Sustainable Systems) process and landfill disposal (S-3), and finally a combination of the MBT/MARSS process with WtE conversion (S-4). The MARSS technology, developed within an European LIFE PLUS framework and currently implemented at pilot plant scale, is an innovative MBT plant having the main goal to yield a Renewable Refined Biomass Fuel (RRBF) to be used for combined heat and power production (CHP) under the regulations enforced for biomass-based plants instead of Waste-to-Energy systems, for increased environmental performance. The four scenarios are characterized by different resource investment for plant and infrastructure construction and different quantities of matter, heat and electricity recovery and recycling. Results, calculated per unit mass of waste treated and per unit exergy delivered, under both multi-input and multi-output LCA perspectives, point out improved performance for scenarios characterized by increased matter and energy recovery. Although none of the investigated scenarios is capable to provide the best performance in all the analyzed impact categories, the scenario S-4 shows the best LCA results in the human toxicity and freshwater eutrophication categories, i.e. the ones with highest impacts in all waste management processes. Copyright © 2015 Elsevier Ltd. All rights reserved.

A comprehensive perinatal patient safety program to reduce preventable adverse outcomes and costs of liability claims.

PubMed

Simpson, Kathleen Rice; Kortz, Carol C; Knox, G Eric

2009-11-01

To achieve the goal of safe care for mothers and infants during labor and birth, Catholic Healthcare Partners (CHP; Cincinnati) conducted on-site risk assessments at the 16 hospitals with perinatal units in 2004-2005, with follow-up visits in 2006 through 2008. ON-SITE RISK ASSESSMENTS: In addition to assessing overall organizational risk, the assessments provided each hospital a gap analysis demonstrating up-to-date and outdated practices and strategies and resources necessary to make all practices consistent with current evidence and national guidelines and standards. CRITICAL ASPECTS OF CLINICAL CARE: Review of claims and near-miss data indicate that fetal assessment, labor induction, and second-stage labor care comprise the majority of risk of perinatal harm. Therefore, these clinical areas were the focus of strategies to promote safety. To promote consistency in knowledge and practice, in 2004 a variety of strategies were recommended, including interdisciplinary fetal monitoring education and routine medical record reviews to monitor ongoing adherence to appropriate practice and documentation. Success in implementing essential structural and process components of the perinatal patient safety program have resulted in improvement from 2003 to 2008 in specific outcomes for the 16 perinatal units surveyed, including reduction of perinatal harm, number of claims, and costs of claims. The program continues to evolve with modifications as needed as more evidence becomes available to guide best perinatal practices and new guidelines/standards are published. A patient safety program guided and supported by a health care system can result in safer clinical environments in individual hospitals and in decreased risk of preventable perinatal harm and liability costs.

Value recovery from two mechanized bucking operations in the southeastern United States

Treesearch

Kevin Boston; Glen. Murphy

2003-01-01

The value recovered from two mechanized bucking operations in the southeastern United States was compared with the optimal value computed using an individual-stem log optimization program, AVIS. The first operation recovered 94% of the optimal value. The main cause for the value loss was a failure to capture potential sawlog volume; logs were bucked to a larger average...

Portfolio theory of optimal isometric force production: Variability predictions and nonequilibrium fluctuation dissipation theorem

NASA Astrophysics Data System (ADS)

Frank, T. D.; Patanarapeelert, K.; Beek, P. J.

2008-05-01

We derive a fundamental relationship between the mean and the variability of isometric force. The relationship arises from an optimal collection of active motor units such that the force variability assumes a minimum (optimal isometric force). The relationship is shown to be independent of the explicit motor unit properties and of the dynamical features of isometric force production. A constant coefficient of variation in the asymptotic regime and a nonequilibrium fluctuation-dissipation theorem for optimal isometric force are predicted.

Expression analysis of chitinase upon challenge inoculation to Alternaria wounding and defense inducers in Brassica juncea.

PubMed

Rawat, Sandhya; Ali, Sajad; Mittra, Bhabatosh; Grover, Anita

2017-03-01

Chitinases are the hydrolytic enzymes which belong to the pathogenesis-related (PR) protein family and play an important role not only in plant defense but also in various abiotic stresses. However, only a limited number of chitinase genes have been characterised in B. juncea . In this study, we have characterised B. juncea class IV chitinase gene (accession no EF586206) in response to fungal infection, salicylic acid (SA), jasmonic acid (JA) treatments and wounding. Gene expression studies revealed that the transcript levels of Bjchitinase ( BjChp ) gene increases significantly both in local and distal tissues after Alternaria infection. Bjchitinase gene was also induced by jasmonic acid and wounding but moderately by salicylic acid. A 2.5 kb class IV chitinase promoter of this gene was isolated from B. juncea by Genome walking (accession no KF055403.1). In-silico analysis of this promoter revealed a number of conserved cis -regulatory elements related to defense, wounding and signalling molecules like SA, and JA. For validation, chitinase promoter was fused to the GUS gene, and the resultant construct was then introduced into Arabidopsis plants. Histochemical analysis of T 2 transgenic Arabidopsis plants showed that higher GUS activity in leaves after fungal infection, wounding and JA treatment but weakly by SA. GUS activity was seen in meristematic tissues, young leaves, seeds and siliques. Finally investigation has led to the identification of a pathogen-inducible, developmentally regulated and organ-specific promoter. Present study revealed that Bjchitinase ( BjChp ) promoter is induced during biotic and environmental stress and it can be used in developing finely tuned transgenics.

Multiple plasmid-borne virulence genes of Clavibacter michiganensis ssp. capsici critical for disease development in pepper.

PubMed

Hwang, In Sun; Oh, Eom-Ji; Kim, Donghyuk; Oh, Chang-Sik

2018-02-01

Clavibacter michiganensis ssp. capsici is a Gram-positive plant-pathogenic bacterium causing bacterial canker disease in pepper. Virulence genes and mechanisms of C. michiganensis ssp. capsici in pepper have not yet been studied. To identify virulence genes of C. michiganensis ssp. capsici, comparative genome analyses with C. michiganensis ssp. capsici and its related C. michiganensis subspecies, and functional analysis of its putative virulence genes during infection were performed. The C. michiganensis ssp. capsici type strain PF008 carries one chromosome (3.056 Mb) and two plasmids (39 kb pCM1 Cmc and 145 kb pCM2 Cmc ). The genome analyses showed that this bacterium lacks a chromosomal pathogenicity island and celA gene that are important for disease development by C. michiganensis ssp. michiganensis in tomato, but carries most putative virulence genes in both plasmids. Virulence of pCM1 Cmc -cured C. michiganensis ssp. capsici was greatly reduced compared with the wild-type strain in pepper. The complementation analysis with pCM1 Cmc -located putative virulence genes showed that at least five genes, chpE, chpG, ppaA1, ppaB1 and pelA1, encoding serine proteases or pectate lyase contribute to disease development in pepper. In conclusion, C. michiganensis ssp. capsici has a unique genome structure, and its multiple plasmid-borne genes play critical roles in virulence in pepper, either separately or together. © 2017 The Authors. New Phytologist © 2017 New Phytologist Trust.

Regulation of transcriptional silencing and chromodomain protein localization at centromeric heterochromatin by histone H3 tyrosine 41 phosphorylation in fission yeast.

PubMed

Ren, Bingbing; Tan, Hwei Ling; Nguyen, Thi Thuy Trang; Sayed, Ahmed Mahmoud Mohammed; Li, Ying; Mok, Yu-Keung; Yang, Henry; Chen, Ee Sin

2018-01-09

Heterochromatin silencing is critical for genomic integrity and cell survival. It is orchestrated by chromodomain (CD)-containing proteins that bind to methylated histone H3 lysine 9 (H3K9me), a hallmark of heterochromatin. Here, we show that phosphorylation of tyrosine 41 (H3Y41p)-a novel histone H3 modification-participates in the regulation of heterochromatin in fission yeast. We show that a loss-of-function mutant of H3Y41 can suppress heterochromatin de-silencing in the centromere and subtelomere repeat regions, suggesting a de-silencing role for H3Y41p on heterochromatin. Furthermore, we show both in vitro and in vivo that H3Y41p differentially regulates two CD-containing proteins without the change in the level of H3K9 methylation: it promotes the binding of Chp1 to histone H3 and the exclusion of Swi6. H3Y41p is preferentially enriched on centromeric heterochromatin during M- to early S phase, which coincides with the localization switch of Swi6/Chp1. The loss-of-function H3Y41 mutant could suppress the hypersensitivity of the RNAi mutants towards hydroxyurea (HU), which arrests replication in S phase. Overall, we describe H3Y41p as a novel histone modification that differentially regulates heterochromatin silencing in fission yeast via the binding of CD-containing proteins. © The Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research.

Ethnic differences in problem perception and perceived need as determinants of referral in young children with problem behaviour.

PubMed

Bevaart, Floor; Mieloo, Cathelijne L; Donker, Marianne C H; Jansen, Wilma; Raat, Hein; Verhulst, Frank C; van Oort, Floor V A

2014-05-01

An underrepresentation of ethnic minority children in mental health care settings is consistently reported. Parents of ethnic minority children are, however, less likely to perceive problem behaviour in their children. Our hypothesis was that, as a result of ethnic differences in problem perception, referral to care by a child health professional (CHP) would be lower for 5- to 6-year-old (high-risk) children from ethnic minority backgrounds than for their peers from the ethnic majority (Dutch origin). For 10,951 children in grade two of elementary school, parents and/or teachers completed the Strengths and Difficulties Questionnaire (SDQ) as well as questions on problem perception (PP) and perceived need for professional care (PN). Referral information was obtained from the Electronic Child Records (ECR) for 1,034 of these children. These children had a high (>90th percentile) SDQ score, and were not receiving mental health care. CHP's referred 144 children (14 %) during the routine health assessments. A lower problem perception was reported by parents of ethnic minority children (40-72 %) than by parents of the ethnic majority group (80 %; p < 0.001), but there were no ethnic differences in referral (OR range 0.9-1.9-p > 0.05). No ethnic differences were found for parental PN, nor for teacher's PP or PN. Despite a lower problem perception in ethnic minority parents when compared to ethnic majority parents, no ethnic differences were found in referral of children with problem behaviour in a preventive health care setting.

Downregulation of N‑Myc inhibits neuroblastoma cell growth via the Wnt/β‑catenin signaling pathway.

PubMed

Wang, Yingge; Gao, Shan; Wang, Weiguang; Xia, Yuting; Liang, Jingyan

2018-05-03

Neuroblastoma, one of the most common types of cancer in childhood, is commonly treated with surgery, radiation and chemotherapy. However, prognosis and survival remain poor for children with high‑risk neuroblastoma. Therefore, the identification of novel, effective therapeutic targets is necessary. N‑Myc, a proto‑oncogene protein encoded by the v‑myc avial myelocytomatosis viral oncogene neuroblastoma derived homolog (MYCN) gene, is associated with tumorigenesis. In the present study, the effect of N‑Myc silencing on MYCN‑amplified CHP134 and BE‑2C neuroblastoma cells was evaluated, and the underlying molecular mechanism was investigated. N‑Myc was successfully knocked down using an N‑Myc‑specific small interfering RNA, the efficacy of interference efficiency confirmed by reverse transcription‑quantitative polymerase chain reaction and western blotting. Cell viability was evaluated by MTT assay and apoptosis was measured by ELISA assay. The results indicated that MYCN silencing significantly decreased cell viability and promoted apoptosis. Subsequently, the expression levels of key Wnt/β‑catenin signaling pathway proteins were detected by western blotting, and MYCN silencing was demonstrated to inhibit Wnt/β‑catenin signaling, decreasing the expression ofanti‑apoptosis proteins and increasing the expression of pro‑apoptosis protein. This suggested that N‑Myc regulated survival and growth of CHP134 and BE‑2C neuroblastoma cells, potentially through Wnt/β‑catenin signaling. Furthermore, associated proteins, N‑Myc and STAT interactor and dickkopf Wnt signaling pathway inhibitor 1, were demonstrated to be involved in this regulation. Therefore, N‑Myc and its downstream targets may provide novel therapeutic targets for the treatment of neuroblastoma.

The Use of Chinese Herbal Medicine in the Treatment of Chronic Obstructive Pulmonary Disease (COPD).

PubMed

Liao, Yen-Nung; Hu, Wen-Long; Chen, Hsuan-Ju; Hung, Yu-Chiang

2017-01-01

In Oriental countries, combinations of Chinese herbal products (CHPs) are often utilized as therapeutic agents for chronic obstructive pulmonary disease (COPD). The effects of CHPs on COPD have been previously reported. This study aimed to analyze the frequency of prescription and usage of CHPs in patients with COPD in Taiwan. In this nationwide population-based cross-sectional study, 19,142 patients from a random sample of one million individuals in the Longitudinal Health Insurance Database 2000 (LHID 2000) of the National Health Insurance Research Database (NHIRD) were enrolled from 2000 to 2011. The multiple logistic regression method was used to evaluate the adjusted odds ratios for the utilization of CHPs. For patients with COPD, there was an average of 6.31 CHPs in a single prescription. The most frequently prescribed CHP for COPD was Xiao-Qing-Long-Tang (XQLT) (2.6%), and the most commonly used combination of two formula CHPs was XQLT with Ma-Xing-Gan-Shi-Tang (MXGST) (1.28%). The most commonly used single CHP for COPD was Bulbus Fritillariae (3.65%), and the most commonly used combination of two single CHPs was Bulbus Fritillariae with Puerariae Lobatae (1.09%). These results provide information regarding personalized therapies and may promote further clinical experiments and pharmacologic research on the use of CHPs for the management of COPD. Furthermore, we found that TCM usage was more prevalent among men, younger, manual workers, residents of Northern Taiwan, and patients with chronic bronchitis and asthma. This information on the distribution of TCM usage around the country is valuable to public health policymakers and clinicians.

Improving health literacy through adult basic education in Australia.

PubMed

Morony, Suzanne; Lamph, Emma; Muscat, Danielle; Nutbeam, Don; Dhillon, Haryana M; Shepherd, Heather; Smith, Sian; Khan, Aisha; Osborne, Julie; Meshreky, Wedyan; Luxford, Karen; Hayen, Andrew; McCaffery, Kirsten J

2017-05-25

Adults with low literacy are less empowered to take care of their health, have poorer health outcomes and higher healthcare costs. We facilitated partnerships between adult literacy teachers and community health providers to deliver a health literacy training program in adult basic education classrooms. Following course completion we interviewed 19 adult education teachers (15 delivering the health literacy program; 4 delivering standard literacy classes) and four community health providers (CHPs) about their experiences, and analysed transcripts using Framework analysis. Written feedback from eight teachers on specific course content was added to the Framework. Health literacy teachers reported a noticeable improvement in their student's health behaviours, confidence, vocabulary to communicate about health, understanding of the health system and language, literacy and numeracy skills. CHP participation was perceived by teachers and CHPs as very successful, with teachers and CHPs reporting they complemented each other's skills. The logistics of coordinating CHPs within the constraints of the adult education setting was a significant obstacle to CHP participation. This study adds to existing evidence that health is an engaging topic for adult learners, and health literacy can be successfully implemented in an adult basic learning curriculum to empower learners to better manage their health. Health workers can deliver targeted health messages in this environment, and introduce local health services. Investment in adult literacy programs teaching health content has potential both to meet the goals of adult language and literacy programs and deliver health benefit in vulnerable populations. © The Author 2017. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Ads' click-through rates predicting based on gated recurrent unit neural networks

NASA Astrophysics Data System (ADS)

Chen, Qiaohong; Guo, Zixuan; Dong, Wen; Jin, Lingzi

2018-05-01

In order to improve the effect of online advertising and to increase the revenue of advertising, the gated recurrent unit neural networks(GRU) model is used as the ads' click through rates(CTR) predicting. Combined with the characteristics of gated unit structure and the unique of time sequence in data, using BPTT algorithm to train the model. Furthermore, by optimizing the step length algorithm of the gated unit recurrent neural networks, making the model reach optimal point better and faster in less iterative rounds. The experiment results show that the model based on the gated recurrent unit neural networks and its optimization of step length algorithm has the better effect on the ads' CTR predicting, which helps advertisers, media and audience achieve a win-win and mutually beneficial situation in Three-Side Game.

Distributed Energy Resources and Dynamic Microgrid: An Integrated Assessment

NASA Astrophysics Data System (ADS)

Shang, Duo Rick

The overall goal of this thesis is to improve understanding in terms of the benefit of DERs to both utility and to electricity end-users when integrated in power distribution system. To achieve this goal, a series of two studies was conducted to assess the value of DERs when integrated with new power paradigms. First, the arbitrage value of DERs was examined in markets with time-variant electricity pricing rates (e.g., time of use, real time pricing) under a smart grid distribution paradigm. This study uses a stochastic optimization model to estimate the potential profit from electricity price arbitrage over a five-year period. The optimization process involves two types of PHEVs (PHEV-10, and PHEV-40) under three scenarios with different assumptions on technology performance, electricity market and PHEV owner types. The simulation results indicate that expected arbitrage profit is not a viable option to engage PHEVs in dispatching and in providing ancillary services without more favorable policy and PHEV battery technologies. Subsidy or change in electricity tariff or both are needed. Second, it examined the concept of dynamic microgrid as a measure to improve distribution resilience, and estimates the prices of this emerging service. An economic load dispatch (ELD) model is developed to estimate the market-clearing price in a hypothetical community with single bid auction electricity market. The results show that the electricity market clearing price on the dynamic microgrid is predominantly decided by power output and cost of electricity of each type of DGs. At circumstances where CHP is the only source, the electricity market clearing price in the island is even cheaper than the on-grid electricity price at normal times. Integration of PHEVs in the dynamic microgrid will increase electricity market clearing prices. It demonstrates that dynamic microgrid is an economically viable alternative to enhance grid resilience.

Climate impact analysis of waste treatment scenarios--thermal treatment of commercial and pretreated waste versus landfilling in Austria.

PubMed

Ragossnig, A M; Wartha, C; Pomberger, R

2009-11-01

A major challenge for modern waste management lies in a smart integration of waste-to-energy installations in local energy systems in such a way that the energy efficiency of the waste-to-energy plant is optimized and that the energy contained in the waste is, therefore, optimally utilized. The extent of integration of thermal waste treatment processes into regular energy supply systems plays a major role with regard to climate control. In this research, the specific waste management situation looked at scenarios aiming at maximizing the energy recovery from waste (i.e. actual scenario and waste-to-energy process with 75% energy efficiency [22.5% electricity, 52.5% heat]) yield greenhouse gas emission savings due to the fact that more greenhouse gas emissions are avoided in the energy sector than caused by the various waste treatment processes. Comparing dedicated waste-to-energy-systems based on the combined heat and power (CHP) process with concepts based on sole electricity production, the energy efficiency proves to be crucial with regard to climate control. This underlines the importance of choosing appropriate sites for waste-to-energy-plants. This research was looking at the effect with regard to the climate impact of various waste management scenarios that could be applied alternatively by a private waste management company in Austria. The research is, therefore, based on a specific set of data for the waste streams looked at (waste characteristics, logistics needed, etc.). Furthermore, the investigated scenarios have been defined based on the actual available alternatives with regard to the usage of treatment plants for this specific company. The standard scenarios for identifying climate impact implications due to energy recovery from waste are based on the respective marginal energy data for the power and heat generation facilities/industrial processes in Austria.

Ada Integrated Environment III Computer Program Development Specification. Volume III. Ada Optimizing Compiler.

DTIC Science & Technology

1981-12-01

file.library-unit{.subunit).SYMAP Statement Map: library-file. library-unit.subunit).SMAP Type Map: 1 ibrary.fi le. 1 ibrary-unit{.subunit). TMAP The library...generator SYMAP Symbol Map code generator SMAP Updated Statement Map code generator TMAP Type Map code generator A.3.5 The PUNIT Command The P UNIT...Core.Stmtmap) NAME Tmap (Core.Typemap) END Example A-3 Compiler Command Stream for the Code Generator Texas Instruments A-5 Ada Optimizing Compiler

Comparing the greenhouse gas emissions from three alternative waste combustion concepts.

PubMed

Vainikka, Pasi; Tsupari, Eemeli; Sipilä, Kai; Hupa, Mikko

2012-03-01

Three alternative condensing mode power and combined heat and power (CHP) waste-to-energy concepts were compared in terms of their impacts on the greenhouse gas (GHG) emissions from a heat and power generation system. The concepts included (i) grate, (ii) bubbling fluidised bed (BFB) and (iii) circulating fluidised bed (CFB) combustion of waste. The BFB and CFB take advantage of advanced combustion technology which enabled them to reach electric efficiency up to 35% and 41% in condensing mode, respectively, whereas 28% (based on the lower heating value) was applied for the grate fired unit. A simple energy system model was applied in calculating the GHG emissions in different scenarios where coal or natural gas was substituted in power generation and mix of fuel oil and natural gas in heat generation by waste combustion. Landfilling and waste transportation were not considered in the model. GHG emissions were reduced significantly in all of the considered scenarios where the waste combustion concepts substituted coal based power generation. With the exception of condensing mode grate incinerator the different waste combustion scenarios resulted approximately in 1 Mton of fossil CO(2)-eq. emission reduction per 1 Mton of municipal solid waste (MSW) incinerated. When natural gas based power generation was substituted by electricity from the waste combustion significant GHG emission reductions were not achieved. Copyright © 2011 Elsevier Ltd. All rights reserved.

Testing of Strategies for the Acceleration of the Cost Optimization

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ponciroli, Roberto; Vilim, Richard B.

The general problem addressed in the Nuclear-Renewable Hybrid Energy System (N-R HES) project is finding the optimum economical dispatch (ED) and capacity planning solutions for the hybrid energy systems. In the present test-problem configuration, the N-R HES unit is composed of three electrical power-generating components, i.e. the Balance of Plant (BOP), the Secondary Energy Source (SES), and the Energy Storage (ES). In addition, there is an Industrial Process (IP), which is devoted to hydrogen generation. At this preliminary stage, the goal is to find the power outputs of each one of the N-R HES unit components (BOP, SES, ES) andmore » the IP hydrogen production level that maximizes the unit profit by simultaneously satisfying individual component operational constraints. The optimization problem is meant to be solved in the Risk Analysis Virtual Environment (RAVEN) framework. The dynamic response of the N-R HES unit components is simulated by using dedicated object-oriented models written in the Modelica modeling language. Though this code coupling provides for very accurate predictions, the ensuing optimization problem is characterized by a very large number of solution variables. To ease the computational burden and to improve the path to a converged solution, a method to better estimate the initial guess for the optimization problem solution was developed. The proposed approach led to the definition of a suitable Monte Carlo-based optimization algorithm (called the preconditioner), which provides an initial guess for the optimal N-R HES power dispatch and the optimal installed capacity for each one of the unit components. The preconditioner samples a set of stochastic power scenarios for each one of the N-R HES unit components, and then for each of them the corresponding value of a suitably defined cost function is evaluated. After having simulated a sufficient number of power histories, the configuration which ensures the highest profit is selected as the optimal one. The component physical dynamics are represented through suitable ramp constraints, which considerably simplify the numerical solving. In order to test the capabilities of the proposed approach, in the present report, the dispatch problem only is tackled, i.e. a reference unit configuration is assumed, and each one of the N-R HES unit components is assumed to have a fixed installed capacity. As for the next steps, the main improvement will concern the operation strategy of the ES facility. In particular, in order to describe a more realistic battery commitment strategy, the ES operation will be regulated according to the electricity price forecasts.« less

Optimization benefits analysis in production process of fabrication components

NASA Astrophysics Data System (ADS)

Prasetyani, R.; Rafsanjani, A. Y.; Rimantho, D.

2017-12-01

The determination of an optimal number of product combinations is important. The main problem at part and service department in PT. United Tractors Pandu Engineering (shortened to PT.UTPE) Is the optimization of the combination of fabrication component products (known as Liner Plate) which influence to the profit that will be obtained by the company. Liner Plate is a fabrication component that serves as a protector of core structure for heavy duty attachment, such as HD Vessel, HD Bucket, HD Shovel, and HD Blade. The graph of liner plate sales from January to December 2016 has fluctuated and there is no direct conclusion about the optimization of production of such fabrication components. The optimal product combination can be achieved by calculating and plotting the amount of production output and input appropriately. The method that used in this study is linear programming methods with primal, dual, and sensitivity analysis using QM software for Windows to obtain optimal fabrication components. In the optimal combination of components, PT. UTPE provide the profit increase of Rp. 105,285,000.00 for a total of Rp. 3,046,525,000.00 per month and the production of a total combination of 71 units per unit variance per month.

Empty tracks optimization based on Z-Map model

NASA Astrophysics Data System (ADS)

Liu, Le; Yan, Guangrong; Wang, Zaijun; Zang, Genao

2017-12-01

For parts with many features, there are more empty tracks during machining. If these tracks are not optimized, the machining efficiency will be seriously affected. In this paper, the characteristics of the empty tracks are studied in detail. Combining with the existing optimization algorithm, a new tracks optimization method based on Z-Map model is proposed. In this method, the tool tracks are divided into the unit processing section, and then the Z-Map model simulation technique is used to analyze the order constraint between the unit segments. The empty stroke optimization problem is transformed into the TSP with sequential constraints, and then through the genetic algorithm solves the established TSP problem. This kind of optimization method can not only optimize the simple structural parts, but also optimize the complex structural parts, so as to effectively plan the empty tracks and greatly improve the processing efficiency.

Study on Operation Optimization of Pumping Station's 24 Hours Operation under Influences of Tides and Peak-Valley Electricity Prices

NASA Astrophysics Data System (ADS)

Yi, Gong; Jilin, Cheng; Lihua, Zhang; Rentian, Zhang

2010-06-01

According to different processes of tides and peak-valley electricity prices, this paper determines the optimal start up time in pumping station's 24 hours operation between the rating state and adjusting blade angle state respectively based on the optimization objective function and optimization model for single-unit pump's 24 hours operation taking JiangDu No.4 Pumping Station for example. In the meantime, this paper proposes the following regularities between optimal start up time of pumping station and the process of tides and peak-valley electricity prices each day within a month: (1) In the rating and adjusting blade angle state, the optimal start up time in pumping station's 24 hours operation which depends on the tide generation at the same day varies with the process of tides. There are mainly two kinds of optimal start up time which include the time at tide generation and 12 hours after it. (2) In the rating state, the optimal start up time on each day in a month exhibits a rule of symmetry from 29 to 28 of next month in the lunar calendar. The time of tide generation usually exists in the period of peak electricity price or the valley one. The higher electricity price corresponds to the higher minimum cost of water pumping at unit, which means that the minimum cost of water pumping at unit depends on the peak-valley electricity price at the time of tide generation on the same day. (3) In the adjusting blade angle state, the minimum cost of water pumping at unit in pumping station's 24 hour operation depends on the process of peak-valley electricity prices. And in the adjusting blade angle state, 4.85%˜5.37% of the minimum cost of water pumping at unit will be saved than that of in the rating state.

An Optimization Framework for Driver Feedback Systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Malikopoulos, Andreas; Aguilar, Juan P.

2013-01-01

Modern vehicles have sophisticated electronic control units that can control engine operation with discretion to balance fuel economy, emissions, and power. These control units are designed for specific driving conditions (e.g., different speed profiles for highway and city driving). However, individual driving styles are different and rarely match the specific driving conditions for which the units were designed. In the research reported here, we investigate driving-style factors that have a major impact on fuel economy and construct an optimization framework to optimize individual driving styles with respect to these driving factors. In this context, we construct a set of polynomialmore » metamodels to reflect the responses produced in fuel economy by changing the driving factors. Then, we compare the optimized driving styles to the original driving styles and evaluate the effectiveness of the optimization framework. Finally, we use this proposed framework to develop a real-time feedback system, including visual instructions, to enable drivers to alter their driving styles in response to actual driving conditions to improve fuel efficiency.« less

Optimization of hydraulic turbine governor parameters based on WPA

NASA Astrophysics Data System (ADS)

Gao, Chunyang; Yu, Xiangyang; Zhu, Yong; Feng, Baohao

2018-01-01

The parameters of hydraulic turbine governor directly affect the dynamic characteristics of the hydraulic unit, thus affecting the regulation capacity and the power quality of power grid. The governor of conventional hydropower unit is mainly PID governor with three adjustable parameters, which are difficult to set up. In order to optimize the hydraulic turbine governor, this paper proposes wolf pack algorithm (WPA) for intelligent tuning since the good global optimization capability of WPA. Compared with the traditional optimization method and PSO algorithm, the results show that the PID controller designed by WPA achieves a dynamic quality of hydraulic system and inhibits overshoot.

[Influence of psychosocial factors on adherence to antihypertensive drug therapy: results from a Cardiovascular Health Program cohort followed in the Metropolitan Region of Santiago, Chile].

PubMed

Sandoval, Daniela; Chacón, Javier; Muñoz, Reinaldo; Henríquez, Óscar; Koch, Elard; Romero, Tomás

2014-10-01

Inadequate blood pressure control in hypertensive patients remains a persistent health problem in Chile and worldwide. Poor adherence to antihypertensive drug therapy is one of the frequently cited factors. To determine the influence of psychosocial factors in the adherence to drug therapy in hypertensive patients followed through a Cardiovascular Health Program (CHP) that provides free access to primary care centers located in the Metropolitan Region of Santiago, Chile. Cross sectional study. A randomized sample of 513 hypertensive patients (30 to 68 years) was obtained from a universe of 1.484 patients. Adherence to treatment was determined by the Morisky-Green-Levine test. Demographic, socioeconomic and average values of blood pressure were recorded. Validated questionnaires were utilized to assess the patient-physician relationship, awareness of being hypertensive, patient perception of social support, family cohesion, patient self-health assessment and symptoms of emotional stress and depression. The drug therapy adherence was 36.6%, higher in women (38.4% vs 28.9%; p < 0.001). After multivariate analysis, absence of adherence was associated with male gender (OR: 1.76 [95% CI 1.21-2.56]), low education (OR: 1.72 [95% CI 1.18 to 2.53]), inadequate patient-physician relationship (OR: 1.56 [95% CI 1.13 to 2.27]), and high level of emotional stress and depression (OR: 1.93 [95% CI 1.27 to 2.94]). Our study highlights the influence of inadequate patient-physician relation, high level of emotional stress and depression, low education level and income and male gender in the lack of adherence to antihypertensive drug therapy in hypertensive patients followed throughout the CHP.

Cyclic hexapeptide-conjugated nanoparticles enhance curcumin delivery to glioma tumor cells and tissue.

PubMed

Zhang, Xuemei; Li, Xuejuan; Hua, Hongchen; Wang, Aiping; Liu, Wanhui; Li, Youxin; Fu, Fenghua; Shi, Yanan; Sun, Kaoxiang

2017-01-01

Glioma has one of the highest mortality rates among primary brain tumors. The clinical treatment for glioma is very difficult due to its infiltration and specific growth locations. To achieve improved drug delivery to a brain tumor, we report the preparation and in vitro and in vivo evaluation of curcumin nanoparticles (Cur-NPs). The cyclic hexapeptide c(RGDf(N-me) VK)-C (cHP) has increased affinity for cells that overexpress integrins and was designed to target Cur-NPs to tumors. Functional polyethyleneglycol-modified poly(d,l-lactide-co-glycolide) (PEG-PLGA) conjugated to cHP was synthesized, and targeted Cur-NPs were prepared using a self-assembly nanoprecipitation process. The physicochemical properties and the in vitro cytotoxicity, accuracy, and penetration capabilities of Cur-NPs targeting cells with high levels of integrin expression were investigated. The in vivo targeting and penetration capabilities of the NPs were also evaluated against glioma in rats using in vivo imaging equipment. The results showed that the in vitro cytotoxicity of the targeted cHP-modified curcumin nanoparticles (cHP/Cur-NPs) was higher than that of either free curcumin or non-targeted Cur-NPs due to the superior ability of the cHP/Cur-NPs to target tumor cells. The targeted cHP/Cur-NPs, c(RGDf(N-me)VK)-C-modified Cur-NPs, exhibited improved binding, uptake, and penetration abilities than non-targeting NPs for glioma cells, cell spheres, and glioma tissue. In conclusion, c(RGDf(N-me)VK)-C can serve as an effective targeting ligand, and cHP/Cur-NPs can be exploited as a potential drug delivery system for targeting gliomas.

Adaptive Strategies and Pathogenesis of Clostridium difficile from In Vivo Transcriptomics

PubMed Central

Janoir, Claire; Denève, Cécile; Bouttier, Sylvie; Barbut, Frédéric; Hoys, Sandra; Caleechum, Laxmee; Chapetón-Montes, Diana; Pereira, Fátima C.; Henriques, Adriano O.; Collignon, Anne; Monot, Marc

2013-01-01

Clostridium difficile is currently the major cause of nosocomial intestinal diseases associated with antibiotic therapy in adults. In order to improve our knowledge of C. difficile-host interactions, we analyzed the genome-wide temporal expression of C. difficile 630 genes during the first 38 h of mouse colonization to identify genes whose expression is modulated in vivo, suggesting that they may play a role in facilitating the colonization process. In the ceca of the C. difficile-monoassociated mice, 549 genes of the C. difficile genome were differentially expressed compared to their expression during in vitro growth, and they were distributed in several functional categories. Overall, our results emphasize the roles of genes involved in host adaptation. Colonization results in a metabolic shift, with genes responsible for the fermentation as well as several other metabolic pathways being regulated inversely to those involved in carbon metabolism. In addition, several genes involved in stress responses, such as ferrous iron uptake or the response to oxidative stress, were regulated in vivo. Interestingly, many genes encoding conserved hypothetical proteins (CHP) were highly and specifically upregulated in vivo. Moreover, genes for all stages of sporulation were quickly induced in vivo, highlighting the observation that sporulation is central to the persistence of C. difficile in the gut and to its ability to spread in the environment. Finally, we inactivated two genes that were differentially expressed in vivo and evaluated the relative colonization fitness of the wild-type and mutant strains in coinfection experiments. We identified a CHP as a putative colonization factor, supporting the suggestion that the in vivo transcriptomic approach can unravel new C. difficile virulence genes. PMID:23897605

Synergistic Response of Rifampicin with Hydroperoxides on Mycobacterium: A Mechanistic Study

PubMed Central

Patel, Yesha S.; Mehra, Sarika

2017-01-01

Prolonged chemotherapy as well as rapid development of antimicrobial resistance are two of the major concerns for treatment of mycobacterial infections. To enhance the effectiveness of current drug regimens, search for compounds having synergistic interaction with anti-mycobacterial drugs has become indispensable. Here, we have investigated the intervention by oxidative stress, a major factor in mycobacterial pathogenesis, in combination with rifampicin (RIF), a first-line drug used against Mycobacterium tuberculosis. We have observed that a sub-inhibitory concentration of cumene hydroperoxide (CHP), a hydrophobic oxidant, synergistically reduced the minimum inhibitory concentration of RIF by fourfold, with a Fractional Inhibitory Concentration Index (FICI) of 0.45. Also, this interaction was found to be robust and synergistic against different strains of M. smegmatis as well as on M. bovis BCG, with FICI ranging from 0.3 to 0.6. Various physiological, biochemical and molecular parameters were explored to understand the mechanism of synergy. It was observed that increased membrane permeability owing to the presence of the oxidant, led to higher uptake of the drug. Moreover, downregulation of the hydroperoxide reductases by RIF, a transcriptional inhibitor, prevented quenching of the reactive oxygen species produced in the presence of CHP. The lipid soluble reactive species triggered autocatalytic lipid peroxidation (LPO), observed here as extensive membrane damage eventually leading to growth inhibition. Furthermore, it was seen that in combination with hydrogen peroxide (H2O2), the effect was only additive, establishing LPO as a key aspect leading toward synergism. To conclude, this work suggests that targeting the bacterial membrane by a radical species can have a significant impact on the treatment of tuberculosis. PMID:29163385

Cyclic hexapeptide-conjugated nanoparticles enhance curcumin delivery to glioma tumor cells and tissue

PubMed Central

Zhang, Xuemei; Li, Xuejuan; Hua, Hongchen; Wang, Aiping; Liu, Wanhui; Li, Youxin; Fu, Fenghua; Shi, Yanan; Sun, Kaoxiang

2017-01-01

Glioma has one of the highest mortality rates among primary brain tumors. The clinical treatment for glioma is very difficult due to its infiltration and specific growth locations. To achieve improved drug delivery to a brain tumor, we report the preparation and in vitro and in vivo evaluation of curcumin nanoparticles (Cur-NPs). The cyclic hexapeptide c(RGDf(N-me) VK)-C (cHP) has increased affinity for cells that overexpress integrins and was designed to target Cur-NPs to tumors. Functional polyethyleneglycol-modified poly(d,l-lactide-co-glycolide) (PEG-PLGA) conjugated to cHP was synthesized, and targeted Cur-NPs were prepared using a self-assembly nanoprecipitation process. The physicochemical properties and the in vitro cytotoxicity, accuracy, and penetration capabilities of Cur-NPs targeting cells with high levels of integrin expression were investigated. The in vivo targeting and penetration capabilities of the NPs were also evaluated against glioma in rats using in vivo imaging equipment. The results showed that the in vitro cytotoxicity of the targeted cHP-modified curcumin nanoparticles (cHP/Cur-NPs) was higher than that of either free curcumin or non-targeted Cur-NPs due to the superior ability of the cHP/Cur-NPs to target tumor cells. The targeted cHP/Cur-NPs, c(RGDf(N-me)VK)-C-modified Cur-NPs, exhibited improved binding, uptake, and penetration abilities than non-targeting NPs for glioma cells, cell spheres, and glioma tissue. In conclusion, c(RGDf(N-me)VK)-C can serve as an effective targeting ligand, and cHP/Cur-NPs can be exploited as a potential drug delivery system for targeting gliomas. PMID:28848349

The Subgingival Microbiome of Periodontal Pockets With Different Probing Depths in Chronic and Aggressive Periodontitis: A Pilot Study.

PubMed

Shi, Meng; Wei, Yiping; Hu, Wenjie; Nie, Yong; Wu, Xiaolei; Lu, Ruifang

2018-01-01

Periodontitis is a kind of infectious disease initiated by colonization of subgingival periodontal pathogens, which cause destruction of tooth-supporting tissues, and is a predominant threat to oral health as the most common cause of loss of teeth. The aim of this pilot study was to characterize the subgingival bacterial biodiversity of periodontal pockets with different probing depths in patients with different forms of periodontitis. Twenty-one subgingival plaque samples were collected from three patients with chronic periodontitis (ChP), three patients with aggressive periodontitis (AgP) and three periodontally healthy subjects (PH). Each patient with periodontitis was sampled at three sites, at different probing depths (PDs, one each at 4 mm, 5-6 mm, and ≥ 7 mm). Using 16S rRNA gene high-throughput sequencing and bioinformatic analysis, we found that subgingival communities in health and periodontitis samples largely differed. Meanwhile, Acholeplasma, Fretibacterium, Porphyromonas, Peptococcus, Treponema_2, Defluviitaleaceae_UCG_011, Filifactor , and Mycoplasma increased with the deepening of the pockets in ChP, whilst only Corynebacterium was negatively associated with PD. In AgP, Corynebacterium and Klebsiella were positively associated with PD, while Serratia, Pseudoramibacter, Defluviitaleaceae_UCG_011 , and Desulfobulbus were negatively associated with PD. And among these two groups, Corynebacterium shifted differently. Moreover, in subgingival plaque, the unweighted UniFrac distances between samples from pockets with different PD in the same patients were significantly lower than those from pockets within the same PD category from different patients. This study demonstrated the shift of the subgingival microbiome in individual teeth sites during disease development. Within the limitation of the relative small sample size, this pilot study shed new light on the dynamic relationship between the extent of periodontal destruction and the subgingival microbiome.

Early detection of children at risk for antisocial behaviour using data from routine preventive child healthcare

PubMed Central

2012-01-01

Background Youth antisocial behaviour is highly prevalent. Young people are usually not willing to disclose such behaviour to professionals and parents. Our aim was to assess whether child health professionals (CHP) working in preventive child healthcare could identify pre-adolescents at risk for antisocial behaviour through using data that they obtain in routine practice. Methods CHPs examined a national sample of 974 pre-adolescents aged 8-12 years (response 79.1%), and interviewed parents and children during routine well-child assessments. We obtained data on family background and current health of the child from the CHP; on developmental concerns from parents, and on social and emotional well-being, injuries, and substance use from the children. Antisocial behaviour concerned the adolescent-reported 15 item International Self-Reported Delinquency study questionnaire, among which are 5 items on violence against people. Results The prevalence of 2+acts of any antisocial behaviour was 21.8%, and 33.9% for 1+acts of violence (10.5% for 2+). Children who were male, had a young mother, no parent employed, recent injuries, poor performance at school or who were bored by school, and who had parental concerns more often reported 2+antisocial acts and 1+violence against people. Detection algorithms on the basis of these variables were moderately able to classify outcomes, with Areas-Under-the-Curves ranging from 0.66 to 0.71. Conclusions Data from routine well-child assessment can help CHPs to detect pre-adolescents at risk for antisocial behaviour, but detection algorithms need to be further improved. This could be done by obtaining additional information on factors that are associated with antisocial behaviour. PMID:22405493

Aberrant DNA methylation of WNT pathway genes in the development and progression of CIMP-negative colorectal cancer.

PubMed

Galamb, Orsolya; Kalmár, Alexandra; Péterfia, Bálint; Csabai, István; Bodor, András; Ribli, Dezső; Krenács, Tibor; Patai, Árpád V; Wichmann, Barnabás; Barták, Barbara Kinga; Tóth, Kinga; Valcz, Gábor; Spisák, Sándor; Tulassay, Zsolt; Molnár, Béla

2016-08-02

The WNT signaling pathway has an essential role in colorectal carcinogenesis and progression, which involves a cascade of genetic and epigenetic changes. We aimed to analyze DNA methylation affecting the WNT pathway genes in colorectal carcinogenesis in promoter and gene body regions using whole methylome analysis in 9 colorectal cancer, 15 adenoma, and 6 normal tumor adjacent tissue (NAT) samples by methyl capture sequencing. Functional methylation was confirmed on 5-aza-2'-deoxycytidine-treated colorectal cancer cell line datasets. In parallel with the DNA methylation analysis, mutations of WNT pathway genes (APC, β-catenin/CTNNB1) were analyzed by 454 sequencing on GS Junior platform. Most differentially methylated CpG sites were localized in gene body regions (95% of WNT pathway genes). In the promoter regions, 33 of the 160 analyzed WNT pathway genes were differentially methylated in colorectal cancer vs. normal, including hypermethylated AXIN2, CHP1, PRICKLE1, SFRP1, SFRP2, SOX17, and hypomethylated CACYBP, CTNNB1, MYC; 44 genes in adenoma vs. NAT; and 41 genes in colorectal cancer vs. adenoma comparisons. Hypermethylation of AXIN2, DKK1, VANGL1, and WNT5A gene promoters was higher, while those of SOX17, PRICKLE1, DAAM2, and MYC was lower in colon carcinoma compared to adenoma. Inverse correlation between expression and methylation was confirmed in 23 genes, including APC, CHP1, PRICKLE1, PSEN1, and SFRP1. Differential methylation affected both canonical and noncanonical WNT pathway genes in colorectal normal-adenoma-carcinoma sequence. Aberrant DNA methylation appears already in adenomas as an early event of colorectal carcinogenesis.

Quantitative Contour Analysis as an Image-based Discriminator Between Benign and Malignant Renal Tumors.

PubMed

Yap, Felix Y; Hwang, Darryl H; Cen, Steven Y; Varghese, Bino A; Desai, Bhushan; Quinn, Brian D; Gupta, Megha Nayyar; Rajarubendra, Nieroshan; Desai, Mihir M; Aron, Manju; Liang, Gangning; Aron, Monish; Gill, Inderbir S; Duddalwar, Vinay A

2018-04-01

To investigate whether morphologic analysis can differentiate between benign and malignant renal tumors on clinically acquired imaging. Between 2009 and 2014, 3-dimensional tumor volumes were manually segmented from contrast-enhanced computerized tomography (CT) images from 150 patients with predominantly solid, nonmacroscopic fat-containing renal tumors: 100 renal cell carcinomas and 50 benign lesions (eg, oncocytoma and lipid-poor angiomyolipoma). Tessellated 3-dimensional tumor models were created from segmented voxels using MATLAB code. Eleven shape descriptors were calculated: sphericity, compactness, mean radial distance, standard deviation of the radial distance, radial distance area ratio, zero crossing, entropy, Feret ratio, convex hull area and convex hull perimeter ratios, and elliptic compactness. Morphometric parameters were compared using the Wilcoxon rank-sum test to investigate whether malignant renal masses demonstrate more morphologic irregularity than benign ones. Only CHP in sagittal orientation (median 0.96 vs 0.97) and EC in coronal orientation (median 0.92 vs 0.93) differed significantly between malignant and benign masses (P = .04). When comparing these 2 metrics between coronal and sagittal orientations, similar but nonsignificant trends emerged (P = .07). Other metrics tested were not significantly different in any imaging plane. Computerized image analysis is feasible using shape descriptors that otherwise cannot be visually assessed and used without quantification. Shape analysis via the transverse orientation may be reasonable, but encompassing all 3 planar dimensions to characterize tumor contour can achieve a more comprehensive evaluation. Two shape metrics (CHP and EC) may help distinguish benign from malignant renal tumors, an often challenging goal to achieve on imaging and biopsy. Copyright © 2017 Elsevier Inc. All rights reserved.

Assessment of biogas production in Argentina from co-digestion of sludge and municipal solid waste.

PubMed

Morero, Betzabet; Vicentin, Rocio; Campanella, Enrique A

2017-03-01

In Argentina, there is an important potential to utilize organic waste to generate bioenergy. This work analyzes the environmental impacts and the energetic and economic requirements of the biogas produced by digesting the sewage sludge (SS) produced in a wastewater treatment plant in a medium city in Argentina. The SS is co-digested with the organic fraction of municipal solid waste (OFMSW), and the basis of this study is the life cycle assessment (LCA). The LCA is performed according to ISO 14040-44 using the SimaPro simulator. First, the transport of the raw materials to the biogas plant was defined. Then, the co-digestion and the biogas treatment for final use were evaluated. The co-digestion was improved with glycerol, and the generation of biogas was estimated using the GPS-X software. Two alternatives for the end use of biogas were considered: combined heat and power (CHP) and biomethane generation. For the first, H 2 S and water vapor were removed from the raw biogas stream, and for the second, also CO 2 was removed. The H 2 S removal process was simulated in the SuperPro software by anaerobic biofiltration. The same software was used to simulate the removal of CO 2 absorption-desorption with water as solvent. Finally, the environmental impacts related to the end use of biogas (CHP and biomethane) were evaluated. The environmental, energetic and economic analyses showed that the co-digestion of SS and OFMSW has great potential for reducing the environmental impacts and increasing the economic and energetic value of the substances via the production of biomethane, electricity and, potentially, fertilizer. Copyright © 2016 Elsevier Ltd. All rights reserved.

Multigenerational memory and adaptive adhesion in early bacterial biofilm communities.

PubMed

Lee, Calvin K; de Anda, Jaime; Baker, Amy E; Bennett, Rachel R; Luo, Yun; Lee, Ernest Y; Keefe, Joshua A; Helali, Joshua S; Ma, Jie; Zhao, Kun; Golestanian, Ramin; O'Toole, George A; Wong, Gerard C L

2018-04-24

Using multigenerational, single-cell tracking we explore the earliest events of biofilm formation by Pseudomonas aeruginosa During initial stages of surface engagement (≤20 h), the surface cell population of this microbe comprises overwhelmingly cells that attach poorly (∼95% stay <30 s, well below the ∼1-h division time) with little increase in surface population. If we harvest cells previously exposed to a surface and direct them to a virgin surface, we find that these surface-exposed cells and their descendants attach strongly and then rapidly increase the surface cell population. This "adaptive," time-delayed adhesion requires determinants we showed previously are critical for surface sensing: type IV pili (TFP) and cAMP signaling via the Pil-Chp-TFP system. We show that these surface-adapted cells exhibit damped, coupled out-of-phase oscillations of intracellular cAMP levels and associated TFP activity that persist for multiple generations, whereas surface-naïve cells show uncorrelated cAMP and TFP activity. These correlated cAMP-TFP oscillations, which effectively impart intergenerational memory to cells in a lineage, can be understood in terms of a Turing stochastic model based on the Pil-Chp-TFP framework. Importantly, these cAMP-TFP oscillations create a state characterized by a suppression of TFP motility coordinated across entire lineages and lead to a drastic increase in the number of surface-associated cells with near-zero translational motion. The appearance of this surface-adapted state, which can serve to define the historical classification of "irreversibly attached" cells, correlates with family tree architectures that facilitate exponential increases in surface cell populations necessary for biofilm formation.

Robust Inference of Cell-to-Cell Expression Variations from Single- and K-Cell Profiling

PubMed Central

Narayanan, Manikandan; Martins, Andrew J.; Tsang, John S.

2016-01-01

Quantifying heterogeneity in gene expression among single cells can reveal information inaccessible to cell-population averaged measurements. However, the expression level of many genes in single cells fall below the detection limit of even the most sensitive technologies currently available. One proposed approach to overcome this challenge is to measure random pools of k cells (e.g., 10) to increase sensitivity, followed by computational “deconvolution” of cellular heterogeneity parameters (CHPs), such as the biological variance of single-cell expression levels. Existing approaches infer CHPs using either single-cell or k-cell data alone, and typically within a single population of cells. However, integrating both single- and k-cell data may reap additional benefits, and quantifying differences in CHPs across cell populations or conditions could reveal novel biological information. Here we present a Bayesian approach that can utilize single-cell, k-cell, or both simultaneously to infer CHPs within a single condition or their differences across two conditions. Using simulated as well as experimentally generated single- and k-cell data, we found situations where each data type would offer advantages, but using both together can improve precision and better reconcile CHP information contained in single- and k-cell data. We illustrate the utility of our approach by applying it to jointly generated single- and k-cell data to reveal CHP differences in several key inflammatory genes between resting and inflammatory cytokine-activated human macrophages, delineating differences in the distribution of ‘ON’ versus ‘OFF’ cells and in continuous variation of expression level among cells. Our approach thus offers a practical and robust framework to assess and compare cellular heterogeneity within and across biological conditions using modern multiplexed technologies. PMID:27438699

A Total Cost of Ownership Model for Low Temperature PEM Fuel Cells in Combined Heat and Power and Backup Power Applications

DOE Office of Scientific and Technical Information (OSTI.GOV)

University of California, Berkeley; Wei, Max; Lipman, Timothy

2014-06-23

A total cost of ownership model is described for low temperature proton exchange membrane stationary fuel cell systems for combined heat and power (CHP) applications from 1-250kW and backup power applications from 1-50kW. System designs and functional specifications for these two applications were developed across the range of system power levels. Bottom-up cost estimates were made for balance of plant costs, and detailed direct cost estimates for key fuel cell stack components were derived using design-for-manufacturing-and-assembly techniques. The development of high throughput, automated processes achieving high yield are projected to reduce the cost for fuel cell stacks to the $300/kWmore » level at an annual production volume of 100 MW. Several promising combinations of building types and geographical location in the U.S. were identified for installation of fuel cell CHP systems based on the LBNL modelling tool DER CAM. Life-cycle modelling and externality assessment were done for hotels and hospitals. Reduced electricity demand charges, heating credits and carbon credits can reduce the effective cost of electricity ($/kWhe) by 26-44percent in locations such as Minneapolis, where high carbon intensity electricity from the grid is displaces by a fuel cell system operating on reformate fuel. This project extends the scope of existing cost studies to include externalities and ancillary financial benefits and thus provides a more comprehensive picture of fuel cell system benefits, consistent with a policy and incentive environment that increasingly values these ancillary benefits. The project provides a critical, new modelling capacity and should aid a broad range of policy makers in assessing the integrated costs and benefits of fuel cell systems versus other distributed generation technologies.« less

Energetic valorization of wood waste: estimation of the reduction in CO2 emissions.

PubMed

Vanneste, J; Van Gerven, T; Vander Putten, E; Van der Bruggen, B; Helsen, L

2011-09-01

This paper investigates the potential CO(2) emission reductions related to a partial switch from fossil fuel-based heat and electricity generation to renewable wood waste-based systems in Flanders. The results show that valorization in large-scale CHP (combined heat and power) systems and co-firing in coal plants have the largest CO(2) reduction per TJ wood waste. However, at current co-firing rates of 10%, the CO(2) reduction per GWh of electricity that can be achieved by co-firing in coal plants is five times lower than the CO(2) reduction per GWh of large-scale CHP. Moreover, analysis of the effect of government support for co-firing of wood waste in coal-fired power plants on the marginal costs of electricity generation plants reveals that the effect of the European Emission Trading Scheme (EU ETS) is effectively counterbalanced. This is due to the fact that biomass integrated gasification combined cycles (BIGCC) are not yet commercially available. An increase of the fraction of coal-based electricity in the total electricity generation from 8 to 10% at the expense of the fraction of gas-based electricity due to the government support for co-firing wood waste, would compensate entirely for the CO(2) reduction by substitution of coal by wood waste. This clearly illustrates the possibility of a 'rebound' effect on the CO(2) reduction due to government support for co-combustion of wood waste in an electricity generation system with large installed capacity of coal- and gas-based power plants, such as the Belgian one. Copyright © 2011 Elsevier B.V. All rights reserved.

Early detection of children at risk for antisocial behaviour using data from routine preventive child healthcare.

PubMed

Reijneveld, Sijmen A; Crone, Matty R; de Meer, Gea

2012-03-09

Youth antisocial behaviour is highly prevalent. Young people are usually not willing to disclose such behaviour to professionals and parents. Our aim was to assess whether child health professionals (CHP) working in preventive child healthcare could identify pre-adolescents at risk for antisocial behaviour through using data that they obtain in routine practice. CHPs examined a national sample of 974 pre-adolescents aged 8-12 years (response 79.1%), and interviewed parents and children during routine well-child assessments. We obtained data on family background and current health of the child from the CHP; on developmental concerns from parents, and on social and emotional well-being, injuries, and substance use from the children. Antisocial behaviour concerned the adolescent-reported 15 item International Self-Reported Delinquency study questionnaire, among which are 5 items on violence against people. The prevalence of 2+acts of any antisocial behaviour was 21.8%, and 33.9% for 1+acts of violence (10.5% for 2+). Children who were male, had a young mother, no parent employed, recent injuries, poor performance at school or who were bored by school, and who had parental concerns more often reported 2+antisocial acts and 1+violence against people. Detection algorithms on the basis of these variables were moderately able to classify outcomes, with Areas-Under-the-Curves ranging from 0.66 to 0.71. Data from routine well-child assessment can help CHPs to detect pre-adolescents at risk for antisocial behaviour, but detection algorithms need to be further improved. This could be done by obtaining additional information on factors that are associated with antisocial behaviour.

Independent Analysis of Real-Time, Measured Performance Data From Microcogenerative Fuel Cell Systems Installed in Buildings

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dillon, Heather E.; Colella, Whitney G.

2015-06-01

Pacific Northwest National Laboratory (PNNL) is working with industry to independently monitor up to 15 distinct 5 kW-electric (kWe) combined heat and power (CHP) high temperature (HT) proton exchange membrane (PEM) fuel cell systems (FCSs) installed in light commercial buildings. This research paper discusses an evaluation of the first six months of measured performance data acquired at a 1 s sampling rate from real-time monitoring equipment attached to the FCSs at building sites. Engineering performance parameters are independently evaluated. Based on an analysis of the first few months of measured operating data, FCS performance is consistent with manufacturer-stated performance. Initialmore » data indicate that the FCSs have relatively stable performance and a long-term average production of about 4.57 kWe of power. This value is consistent with, but slightly below, the manufacturer's stated rated electric power output of 5 kWe. The measured system net electric efficiency has averaged 33.7%, based on the higher heating value (HHV) of natural gas fuel. This value, also, is consistent with, but slightly below, the manufacturer's stated rated electric efficiency of 36%. The FCSs provide low-grade hot water to the building at a measured average temperature of about 48.4 degrees C, lower than the manufacturer's stated maximum hot water delivery temperature of 65 degrees C. The uptime of the systems is also evaluated. System availability can be defined as the quotient of total operating time compared to time since commissioning. The average values for system availability vary between 96.1 and 97.3%, depending on the FCS evaluated in the field. Performance at rated value for electrical efficiency (PRVeff) can be defined as the quotient of the system time operating at or above the rated electric efficiency and the time since commissioning. The PRVeff varies between 5.6% and 31.6%, depending on the FCS field unit evaluated. Performance at rated value for electrical power (PRVp) can be defined as the quotient of the system time operating at or above the rated electric power and the time since commissioning. PRVp varies between 6.5% and 16.2%. Performance at rated value for electrical efficiency and power (PRVt) can be defined as the quotient of the system time operating at or above both the rated electric efficiency and the electric power output compared to the time since commissioning. PRVt varies between 0.2% and 1.4%. Optimization to determine the manufacturer rating required to achieve PRVt greater than 80% has been performed based on the collected data. For example, for FCS Unit 130 to achieve a PRVt of 95%, it would have to be down-rated to an electrical power output of 3.2 kWe and an electrical efficiency of 29%. The use of PRV as an assessment metric for FCSs has been developed and reported for the first time in this paper. For FCS Unit 130, a maximum decline in electric power output of approximately 18% was observed over a 500 h period in Jan. 2012.« less

Optimizing landslide susceptibility zonation: Effects of DEM spatial resolution and slope unit delineation on logistic regression models

NASA Astrophysics Data System (ADS)

Schlögel, R.; Marchesini, I.; Alvioli, M.; Reichenbach, P.; Rossi, M.; Malet, J.-P.

2018-01-01

We perform landslide susceptibility zonation with slope units using three digital elevation models (DEMs) of varying spatial resolution of the Ubaye Valley (South French Alps). In so doing, we applied a recently developed algorithm automating slope unit delineation, given a number of parameters, in order to optimize simultaneously the partitioning of the terrain and the performance of a logistic regression susceptibility model. The method allowed us to obtain optimal slope units for each available DEM spatial resolution. For each resolution, we studied the susceptibility model performance by analyzing in detail the relevance of the conditioning variables. The analysis is based on landslide morphology data, considering either the whole landslide or only the source area outline as inputs. The procedure allowed us to select the most useful information, in terms of DEM spatial resolution, thematic variables and landslide inventory, in order to obtain the most reliable slope unit-based landslide susceptibility assessment.

Optimizing the Shunting Schedule of Electric Multiple Units Depot Using an Enhanced Particle Swarm Optimization Algorithm

PubMed Central

Jin, Junchen

2016-01-01

The shunting schedule of electric multiple units depot (SSED) is one of the essential plans for high-speed train maintenance activities. This paper presents a 0-1 programming model to address the problem of determining an optimal SSED through automatic computing. The objective of the model is to minimize the number of shunting movements and the constraints include track occupation conflicts, shunting routes conflicts, time durations of maintenance processes, and shunting running time. An enhanced particle swarm optimization (EPSO) algorithm is proposed to solve the optimization problem. Finally, an empirical study from Shanghai South EMU Depot is carried out to illustrate the model and EPSO algorithm. The optimization results indicate that the proposed method is valid for the SSED problem and that the EPSO algorithm outperforms the traditional PSO algorithm on the aspect of optimality. PMID:27436998

Development of a biorefinery optimized biofuel supply curve for the western United States

Treesearch

Nathan Parker; Peter Tittmann; Quinn Hart; Richard Nelson; Ken Skog; Anneliese Schmidt; Edward Gray; Bryan Jenkins

2010-01-01

A resource assessment and biorefinery siting optimization model was developed and implemented to assess potential biofuel supply across the Western United States from agricultural, forest, urban, and energy crop biomass. Spatial information including feedstock resources, existing and potential refinery locations and a transportation network model is provided to a mixed...

76 FR 5832 - International Business Machines (IBM), Software Group Business Unit, Optim Data Studio Tools QA...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-02

... DEPARTMENT OF LABOR Employment and Training Administration [TA-W-74,554] International Business Machines (IBM), Software Group Business Unit, Optim Data Studio Tools QA, San Jose, CA; Notice of... determination of the TAA petition filed on behalf of workers at International Business Machines (IBM), Software...

Green-House-Gas-Reduced Coal-and-Biomass-to-Liquid-Based Jet Fuel (GHGR-CBTL) Process - Final Technical report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lux, Kenneth; Imam, Thamina; Chevanan, Nehru

This Final Technical Report describes the work and accomplishments of the project entitled, “Green-House-Gas-Reduced Coal-and-Biomass-to-Liquid-Based Jet Fuel (GHGR-CBTL) Process”. The main objective of the project was to raise the Technology Readiness Level (TRL) of the GHGR-CBTL fuel-production technology from TRL 4 to TRL 5 by producing a drop-in synthetic Jet Propellant 8 (JP-8) with a greenhouse-gas footprint less than or equal to petroleum-based JP-8 by utilizing mixtures of coal and biomass as the feedstock. The system utilizes the patented Altex fuel-production technology, which incorporates advanced catalysts developed by Pennsylvania State University. While the system was not fabricated and tested, majormore » efforts were expended to design the 1-TPD and a full-scale plant. The system was designed, a Block-Flow Diagram (BFD), a Process-Flow Diagram (PFD), and Piping-and-Instrumentation Diagrams (P&IDs) were produced, a Bill of Materials (BOM) and associated spec sheets were produced, commercially available components were selected and procured, custom components were designed and fabricated, catalysts were developed and screened for performance, and permitting activities were conducted. Optimization tests for JP-8 production using C2 olefin as the feed were performed over a range of temperatures, pressures and WHSVs. Liquid yields of between 63 to 65% with 65% JP-8 fraction (41-42% JP-8 yield) at 50 psig were achieved. Life-Cycle Analysis (LCA) was performed by Argonne National Laboratory (ANL), and a GHGR-CBTL module was added to the Greenhouse gases, Regulated Emissions, and Energy use in Transportation (GREET®) model. Based upon the experimental results, the plant design was reconfigured for zero natural-gas imports and minimal electricity imports. The LCA analysis of the reconfigured process utilizing the GREET model showed that if the char from the process was utilized to produce combined heat and power (CHP) then a feed containing 23 wt% biomass and 77 wt% lignite would be needed for parity with petroleum-based JP-8. If the char is not utilized for CHP, but sequestered in a land fill, 24 wt% biomass and 76 wt% lignite would be required. A TEA was performed on this configuration following DOE guidelines and using the ANL-developed GREET module that showed that the GHGR-CBTL TOC and ECO are 69% and 58% of those for the DOE FT-Liquids Baseline Case, respectively. This analysis shows that the economics of the GHGR-CBTL process are significantly better than a gasification/FT process. No technical barriers were identified. The lower costs and the detailed design that was performed under this project are being used by Altex to attract funding partners to move the GHGR-CBTL development forward.« less

Wideband Scattering Diffusion by using Diffraction of Periodic Surfaces and Optimized Unit Cell Geometries

PubMed Central

Costa, Filippo; Monorchio, Agostino; Manara, Giuliano

2016-01-01

A methodology to obtain wideband scattering diffusion based on periodic artificial surfaces is presented. The proposed surfaces provide scattering towards multiple propagation directions across an extremely wide frequency band. They comprise unit cells with an optimized geometry and arranged in a periodic lattice characterized by a repetition period larger than one wavelength which induces the excitation of multiple Floquet harmonics. The geometry of the elementary unit cell is optimized in order to minimize the reflection coefficient of the fundamental Floquet harmonic over a wide frequency band. The optimization of FSS geometry is performed through a genetic algorithm in conjunction with periodic Method of Moments. The design method is verified through full-wave simulations and measurements. The proposed solution guarantees very good performance in terms of bandwidth-thickness ratio and removes the need of a high-resolution printing process. PMID:27181841

[Studies on chemical constituents from roots of Mirabilis jalapa].

PubMed

Lai, Guo-Fang; Luo, Shi-De; Cao, Jian-Xin; Wang, Yi-Fen

2008-01-01

To investigate the anti-HIV constituents from the root of Mirabilis jalapa. The compounds were isolated by column chromatography on silica gel, Sephadex LH - 20, MCI-gel CHP-20P and RP-18. The structure were identified by means of NMR and MS analyses (1H-NMR, 13C-NMR, MS). Eleven compounds were isolated and identified as astragaloside II (1), astragaloside II (2), astragaloside IV (3), astragaloside VI (4), flazin (5), 4'-hydroxy-2, 3-dihydroflavone 7-beta-D-glucopyranoside (6), gingerglycolipid A (7), 3, 4-dihydroxybenzaldehyd (8), p-hydroxybenzaldehyde (9), beta-sitosterol (10) and daucosterol (11). Compounds 1-9 were obtained from this genus for the first time.

Sandia and NJ TRANSIT Authority Developing Resilient Power Grid

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hanley, Charles J.; Ellis, Abraham

2014-11-01

Through the memorandum of understanding between the Depratment of Energy (DOE), the New Jersey Transit Authority (NJ Transit), and the New Jersey Board of Public Utilities, Sandia National Labs is assisting NJ Transit in developing NJ TransitGrid: an electric microgrid that will include a large-scale gas-fired generation facility and distributed energy resources (photovoltaics [PV], energy storage, electric vehicles, combined heat and power [CHP]) to supply reliable power during storms or other times of significant power failure. The NJ TransitGrid was awarded $410M from the Department of Transportation to develop a first-of-its-kind electric microgrid capable of supplying highly-reliable power.

Speedup for quantum optimal control from automatic differentiation based on graphics processing units

NASA Astrophysics Data System (ADS)

Leung, Nelson; Abdelhafez, Mohamed; Koch, Jens; Schuster, David

2017-04-01

We implement a quantum optimal control algorithm based on automatic differentiation and harness the acceleration afforded by graphics processing units (GPUs). Automatic differentiation allows us to specify advanced optimization criteria and incorporate them in the optimization process with ease. We show that the use of GPUs can speedup calculations by more than an order of magnitude. Our strategy facilitates efficient numerical simulations on affordable desktop computers and exploration of a host of optimization constraints and system parameters relevant to real-life experiments. We demonstrate optimization of quantum evolution based on fine-grained evaluation of performance at each intermediate time step, thus enabling more intricate control on the evolution path, suppression of departures from the truncated model subspace, as well as minimization of the physical time needed to perform high-fidelity state preparation and unitary gates.

Method to optimize optical switch topology for photonic network-on-chip

NASA Astrophysics Data System (ADS)

Zhou, Ting; Jia, Hao

2018-04-01

In this paper, we propose a method to optimize the optical switch by substituting optical waveguide crossings for optical switching units and an optimizing algorithm to complete the optimization automatically. The functionality of the optical switch remains constant under optimization. With this method, we simplify the topology of optical switch, which means the insertion loss and power consumption of the whole optical switch can be effectively minimized. Simulation result shows that the number of switching units of the optical switch based on Spanke-Benes can be reduced by 16.7%, 20%, 20%, 19% and 17.9% for the scale from 4 × 4 to 8 × 8 respectively. As a proof of concept, the experimental demonstration of an optimized six-port optical switch based on Spanke-Benes structure by means of silicon photonics chip is reported.

Optimal tree increment models for the Northeastern United Statesq

Treesearch

Don C. Bragg

2003-01-01

used the potential relative increment (PRI) methodology to develop optimal tree diameter growth models for the Northeastern United States. Thirty species from the Eastwide Forest Inventory Database yielded 69,676 individuals, which were then reduced to fast-growing subsets for PRI analysis. For instance, only 14 individuals from the greater than 6,300-tree eastern...

Optimal Tree Increment Models for the Northeastern United States

Treesearch

Don C. Bragg

2005-01-01

I used the potential relative increment (PRI) methodology to develop optimal tree diameter growth models for the Northeastern United States. Thirty species from the Eastwide Forest Inventory Database yielded 69,676 individuals, which were then reduced to fast-growing subsets for PRI analysis. For instance, only 14 individuals from the greater than 6,300-tree eastern...

Stochastic Price Models and Optimal Tree Cutting: Results for Loblolly Pine

Treesearch

Robert G. Haight; Thomas P. Holmes

1991-01-01

An empirical investigation of stumpage price models and optimal harvest policies is conducted for loblolly pine plantations in the southeastern United States. The stationarity of monthly and quarterly series of sawtimber prices is analyzed using a unit root test. The statistical evidence supports stationary autoregressive models for the monthly series and for the...

Factors Contributing to Optimal Human Functioning in People of Color in the United States

ERIC Educational Resources Information Center

Constantine, Madonna G.; Sue, Derald Wing

2006-01-01

Many conceptualizations of optimal human functioning are based on Western European notions of healthy and unhealthy development and daily living. When applied to people of color in the United States, however, these conceptualizations may prove inapplicable because of their Western culture--bound nature. The authors explore the role that cultural…

Near-optimal response of instantaneous transpiration efficiency to vapour pressure deficit, temperature and [CO2] in cotton (Gossypium hirsutum L.).

USDA-ARS?s Scientific Manuscript database

The instantaneous transpiration efficiency (ITE, the ratio of photosynthesis rate to transpiration) is an important variable for crops, because it ultimately affects dry mass production per unit of plant water lost to the atmosphere. The theory that stomata optimize carbon uptake per unit water used...

A genetic algorithm solution to the unit commitment problem

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kazarlis, S.A.; Bakirtzis, A.G.; Petridis, V.

1996-02-01

This paper presents a Genetic Algorithm (GA) solution to the Unit Commitment problem. GAs are general purpose optimization techniques based on principles inspired from the biological evolution using metaphors of mechanisms such as natural selection, genetic recombination and survival of the fittest. A simple Ga algorithm implementation using the standard crossover and mutation operators could locate near optimal solutions but in most cases failed to converge to the optimal solution. However, using the Varying Quality Function technique and adding problem specific operators, satisfactory solutions to the Unit Commitment problem were obtained. Test results for systems of up to 100 unitsmore » and comparisons with results obtained using Lagrangian Relaxation and Dynamic Programming are also reported.« less

Mathematical modeling of synthetic unit hydrograph case study: Citarum watershed

NASA Astrophysics Data System (ADS)

Islahuddin, Muhammad; Sukrainingtyas, Adiska L. A.; Kusuma, M. Syahril B.; Soewono, Edy

2015-09-01

Deriving unit hydrograph is very important in analyzing watershed's hydrologic response of a rainfall event. In most cases, hourly measures of stream flow data needed in deriving unit hydrograph are not always available. Hence, one needs to develop methods for deriving unit hydrograph for ungagged watershed. Methods that have evolved are based on theoretical or empirical formulas relating hydrograph peak discharge and timing to watershed characteristics. These are usually referred to Synthetic Unit Hydrograph. In this paper, a gamma probability density function and its variant are used as mathematical approximations of a unit hydrograph for Citarum Watershed. The model is adjusted with real field condition by translation and scaling. Optimal parameters are determined by using Particle Swarm Optimization method with weighted objective function. With these models, a synthetic unit hydrograph can be developed and hydrologic parameters can be well predicted.

Optimization of Driving Styles for Fuel Economy Improvement

DOE Office of Scientific and Technical Information (OSTI.GOV)

Malikopoulos, Andreas; Aguilar, Juan P.

2012-01-01

Modern vehicles have sophisticated electronic control units, particularly to control engine operation with respect to a balance between fuel economy, emissions, and power. These control units are designed for specific driving conditions and testing. However, each individual driving style is different and rarely meets those driving conditions. In the research reported here we investigate those driving style factors that have a major impact on fuel economy. An optimization framework is proposed with the aim of optimizing driving styles with respect to these driving factors. A set of polynomial metamodels are constructed to reflect the responses produced by changes of themore » driving factors. Then we compare the optimized driving styles to the original ones and evaluate the efficiency and effectiveness of the optimization formulation.« less

Swarm based mean-variance mapping optimization (MVMOS) for solving economic dispatch

NASA Astrophysics Data System (ADS)

Khoa, T. H.; Vasant, P. M.; Singh, M. S. Balbir; Dieu, V. N.

2014-10-01

The economic dispatch (ED) is an essential optimization task in the power generation system. It is defined as the process of allocating the real power output of generation units to meet required load demand so as their total operating cost is minimized while satisfying all physical and operational constraints. This paper introduces a novel optimization which named as Swarm based Mean-variance mapping optimization (MVMOS). The technique is the extension of the original single particle mean-variance mapping optimization (MVMO). Its features make it potentially attractive algorithm for solving optimization problems. The proposed method is implemented for three test power systems, including 3, 13 and 20 thermal generation units with quadratic cost function and the obtained results are compared with many other methods available in the literature. Test results have indicated that the proposed method can efficiently implement for solving economic dispatch.

Statistical Power and Optimum Sample Allocation Ratio for Treatment and Control Having Unequal Costs Per Unit of Randomization

ERIC Educational Resources Information Center

Liu, Xiaofeng

2003-01-01

This article considers optimal sample allocation between the treatment and control condition in multilevel designs when the costs per sampling unit vary due to treatment assignment. Optimal unequal allocation may reduce the cost from that of a balanced design without sacrificing any power. The optimum sample allocation ratio depends only on the…

Energy-Efficient Next-Generation Passive Optical Networks Based on Sleep Mode and Heuristic Optimization

NASA Astrophysics Data System (ADS)

Zulai, Luis G. T.; Durand, Fábio R.; Abrão, Taufik

2015-05-01

In this article, an energy-efficiency mechanism for next-generation passive optical networks is investigated through heuristic particle swarm optimization. Ten-gigabit Ethernet-wavelength division multiplexing optical code division multiplexing-passive optical network next-generation passive optical networks are based on the use of a legacy 10-gigabit Ethernet-passive optical network with the advantage of using only an en/decoder pair of optical code division multiplexing technology, thus eliminating the en/decoder at each optical network unit. The proposed joint mechanism is based on the sleep-mode power-saving scheme for a 10-gigabit Ethernet-passive optical network, combined with a power control procedure aiming to adjust the transmitted power of the active optical network units while maximizing the overall energy-efficiency network. The particle swarm optimization based power control algorithm establishes the optimal transmitted power in each optical network unit according to the network pre-defined quality of service requirements. The objective is controlling the power consumption of the optical network unit according to the traffic demand by adjusting its transmitter power in an attempt to maximize the number of transmitted bits with minimum energy consumption, achieving maximal system energy efficiency. Numerical results have revealed that it is possible to save 75% of energy consumption with the proposed particle swarm optimization based sleep-mode energy-efficiency mechanism compared to 55% energy savings when just a sleeping-mode-based mechanism is deployed.

Size principle and information theory.

PubMed

Senn, W; Wyler, K; Clamann, H P; Kleinle, J; Lüscher, H R; Müller, L

1997-01-01

The motor units of a skeletal muscle may be recruited according to different strategies. From all possible recruitment strategies nature selected the simplest one: in most actions of vertebrate skeletal muscles the recruitment of its motor units is by increasing size. This so-called size principle permits a high precision in muscle force generation since small muscle forces are produced exclusively by small motor units. Larger motor units are activated only if the total muscle force has already reached certain critical levels. We show that this recruitment by size is not only optimal in precision but also optimal in an information theoretical sense. We consider the motoneuron pool as an encoder generating a parallel binary code from a common input to that pool. The generated motoneuron code is sent down through the motoneuron axons to the muscle. We establish that an optimization of this motoneuron code with respect to its information content is equivalent to the recruitment of motor units by size. Moreover, maximal information content of the motoneuron code is equivalent to a minimal expected error in muscle force generation.

Stochastic Optimization for Unit Commitment-A Review

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zheng, Qipeng P.; Wang, Jianhui; Liu, Andrew L.

2015-07-01

Optimization models have been widely used in the power industry to aid the decision-making process of scheduling and dispatching electric power generation resources, a process known as unit commitment (UC). Since UC's birth, there have been two major waves of revolution on UC research and real life practice. The first wave has made mixed integer programming stand out from the early solution and modeling approaches for deterministic UC, such as priority list, dynamic programming, and Lagrangian relaxation. With the high penetration of renewable energy, increasing deregulation of the electricity industry, and growing demands on system reliability, the next wave ismore » focused on transitioning from traditional deterministic approaches to stochastic optimization for unit commitment. Since the literature has grown rapidly in the past several years, this paper is to review the works that have contributed to the modeling and computational aspects of stochastic optimization (SO) based UC. Relevant lines of future research are also discussed to help transform research advances into real-world applications.« less

Optimizing management of the condensing heat and cooling of gases compression in oxy block using of a genetic algorithm

NASA Astrophysics Data System (ADS)

Brzęczek, Mateusz; Bartela, Łukasz

2013-12-01

This paper presents the parameters of the reference oxy combustion block operating with supercritical steam parameters, equipped with an air separation unit and a carbon dioxide capture and compression installation. The possibility to recover the heat in the analyzed power plant is discussed. The decision variables and the thermodynamic functions for the optimization algorithm were identified. The principles of operation of genetic algorithm and methodology of conducted calculations are presented. The sensitivity analysis was performed for the best solutions to determine the effects of the selected variables on the power and efficiency of the unit. Optimization of the heat recovery from the air separation unit, flue gas condition and CO2 capture and compression installation using genetic algorithm was designed to replace the low-pressure section of the regenerative water heaters of steam cycle in analyzed unit. The result was to increase the power and efficiency of the entire power plant.

Constrained Optimal Transport

NASA Astrophysics Data System (ADS)

Ekren, Ibrahim; Soner, H. Mete

2018-03-01

The classical duality theory of Kantorovich (C R (Doklady) Acad Sci URSS (NS) 37:199-201, 1942) and Kellerer (Z Wahrsch Verw Gebiete 67(4):399-432, 1984) for classical optimal transport is generalized to an abstract framework and a characterization of the dual elements is provided. This abstract generalization is set in a Banach lattice X with an order unit. The problem is given as the supremum over a convex subset of the positive unit sphere of the topological dual of X and the dual problem is defined on the bi-dual of X. These results are then applied to several extensions of the classical optimal transport.

Optimal Assignment Problem Applications of Finite Mathematics to Business and Economics. [and] Difference Equations with Applications. Applications of Difference Equations to Economics and Social Sciences. [and] Selected Applications of Mathematics to Finance and Investment. Applications of Elementary Algebra to Finance. [and] Force of Interest. Applications of Calculus to Finance. UMAP Units 317, 322, 381, 382.

ERIC Educational Resources Information Center

Gale, David; And Others

Four units make up the contents of this document. The first examines applications of finite mathematics to business and economies. The user is expected to learn the method of optimization in optimal assignment problems. The second module presents applications of difference equations to economics and social sciences, and shows how to: 1) interpret…

Design, Analysis, and Interpretation of Screening Studies for Human Factors Engineering Research. Revision.

DTIC Science & Technology

1978-06-01

FNO GlX GJP GMO HIP HJ( 11MN ILO JLN KLb: B ABCD AC? ADO AE1 AHL A J t’ Ar*N AD? CDL CEM CON CiJ ChP CN 0 DEN DFH D1K DJ? DMO EFJ ECK EHI’ EiD FUL FIN...Westlake Village, CA 91361 II.- CoN TIro I ING OFF 1C- NAME., AN C) AP"tOFF 12 R.. POFRT o AT " Air Force Office of Scientific Research September 1977...explains the techniques devel- oped by Box and Hunter (1961) and Daniel (1962) for con - structing Resolution IV screening designs from two Resolution

High Temperature Adhesive Systems

DTIC Science & Technology

1989-04-01

Condition Yield Characterizat ion Comments XXXII CN SiC) ( xs ) Combustion quingline 7% Analysis Ref. 19 CN 220"C,2h IR CN C13SiOSiCI 3 XXXII quinoline 23.6...IR Ref. 19 %91CN 219"C,4h NHM CN Na0CH 3 mp 195-196’C NH CHP0H 43% Ref. 18 XXX (D CN Re lux, 3hXXXI ONM SiC1 4 ( xs ) IR XXXII XXXI qulnoline 71.7% Ref...18 219"C, 0.5h XXXI • -CN NaOCH 3 50% mp 192-196C Ref. 16 CH30H CN reflux, 3h SiCI4 ( xs ) Combustion XXXII XXXI quinoline 58./% Analysis Ref.16 219

Gulf Coast Clean Energy Application Center

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dillingham, Gavin

The Gulf Coast Clean Energy Application Center was initiated to significantly improve market and regulatory conditions for the implementation of combined heat and power technologies. The GC CEAC was responsible for the development of CHP in Texas, Louisiana and Oklahoma. Through this program we employed a variety of outreach and education techniques, developed and deployed assessment tools and conducted market assessments. These efforts resulted in the growth of the combined heat and power market in the Gulf Coast region with a realization of more efficient energy generation, reduced emissions and a more resilient infrastructure. Specific t research, we did notmore » formally investigate any techniques with any formal research design or methodology.« less

Design and optimization of membrane-type acoustic metamaterials

NASA Astrophysics Data System (ADS)

Blevins, Matthew Grant

One of the most common problems in noise control is the attenuation of low frequency noise. Typical solutions require barriers with high density and/or thickness. Membrane-type acoustic metamaterials are a novel type of engineered material capable of high low-frequency transmission loss despite their small thickness and light weight. These materials are ideally suited to applications with strict size and weight limitations such as aircraft, automobiles, and buildings. The transmission loss profile can be manipulated by changing the micro-level substructure, stacking multiple unit cells, or by creating multi-celled arrays. To date, analysis has focused primarily on experimental studies in plane-wave tubes and numerical modeling using finite element methods. These methods are inefficient when used for applications that require iterative changes to the structure of the material. To facilitate design and optimization of membrane-type acoustic metamaterials, computationally efficient dynamic models based on the impedance-mobility approach are proposed. Models of a single unit cell in a waveguide and in a baffle, a double layer of unit cells in a waveguide, and an array of unit cells in a baffle are studied. The accuracy of the models and the validity of assumptions used are verified using a finite element method. The remarkable computational efficiency of the impedance-mobility models compared to finite element methods enables implementation in design tools based on a graphical user interface and in optimization schemes. Genetic algorithms are used to optimize the unit cell design for a variety of noise reduction goals, including maximizing transmission loss for broadband, narrow-band, and tonal noise sources. The tools for design and optimization created in this work will enable rapid implementation of membrane-type acoustic metamaterials to solve real-world noise control problems.

A Transformation Approach to Optimal Control Problems with Bounded State Variables

NASA Technical Reports Server (NTRS)

Hanafy, Lawrence Hanafy

1971-01-01

A technique is described and utilized in the study of the solutions to various general problems in optimal control theory, which are converted in to Lagrange problems in the calculus of variations. This is accomplished by mapping certain properties in Euclidean space onto closed control and state regions. Nonlinear control problems with a unit m cube as control region and unit n cube as state region are considered.

Optimization of a Nucleic Acids united-RESidue 2-Point model (NARES-2P) with a maximum-likelihood approach

NASA Astrophysics Data System (ADS)

He, Yi; Liwo, Adam; Scheraga, Harold A.

2015-12-01

Coarse-grained models are useful tools to investigate the structural and thermodynamic properties of biomolecules. They are obtained by merging several atoms into one interaction site. Such simplified models try to capture as much as possible information of the original biomolecular system in all-atom representation but the resulting parameters of these coarse-grained force fields still need further optimization. In this paper, a force field optimization method, which is based on maximum-likelihood fitting of the simulated to the experimental conformational ensembles and least-squares fitting of the simulated to the experimental heat-capacity curves, is applied to optimize the Nucleic Acid united-RESidue 2-point (NARES-2P) model for coarse-grained simulations of nucleic acids recently developed in our laboratory. The optimized NARES-2P force field reproduces the structural and thermodynamic data of small DNA molecules much better than the original force field.

Economic environmental dispatch using BSA algorithm

NASA Astrophysics Data System (ADS)

Jihane, Kartite; Mohamed, Cherkaoui

2018-05-01

Economic environmental dispatch problem (EED) is an important issue especially in the field of fossil fuel power plant system. It allows the network manager to choose among different units the most optimized in terms of fuel costs and emission level. The objective of this paper is to minimize the fuel cost with emissions constrained; the test is conducted for two cases: six generator unit and ten generator unit for the same power demand 1200Mw. The simulation has been computed in MATLAB and the result shows the robustness of the Backtracking Search optimization Algorithm (BSA) and the impact of the load demand on the emission.

[Reorganization of the interdisciplinary emergency unit at the university clinic of Göttingen].

PubMed

Blaschke, Sabine; Müller, Gerhard A; Bergmann, Günther

2008-04-01

Configuration of the interdisciplinary emergency unit within the university clinic of Göttingen was successfully reorganized during the past two years. All emergencies except traumatologic, gynecologic and pediatric emergencies are treated within this functional unit which is guided by the center of internal medicine. It is organized in a three shift operation manner over a period of 24 hours. Due to a close interdisciplinary collaboration between different departments patients receive optimal diagnostic and therapeutic treatment within a short period of time. To improve processes within the emergency department a series of measures were taken including the -establishment of an intermediate care unit for unstable patients, setting up of special diagnostic and therapeutic units for the acute coronary syndrome as well as stroke, implementation of standardized clinical pathways, establishment of an electronic data processing network in close communication with all diagnostic entities, introduction of a quality assurance system and reduction of medical costs. Reorganization measures lead to a substantial optimization and acceleration of emergency proceedings and thus, provides optimal patient care around the clock. In addition, medical costs could clearly be reduced at the interface between preclinical and clinical emergency medicine.

Cutting and coagulation during intraoral soft tissue surgery using Er: YAG laser.

PubMed

Onisor, I; Pecie, R; Chaskelis, I; Krejci, I

2013-06-01

To find the optimal techniques and parameters that enables Er:YAG laser to be used successfully for small intraoral soft tissue interventions, in respect to its cutting and coagulation abilities. In vitro pre-tests: 4 different Er:YAG laser units and one CO2 unit as the control were used for incision and coagulation on porcine lower jaws and optimal parameters were established for each type of intervention and each laser unit: energy, frequency, type, pulse duration and distance. 3 different types of intervention using Er:YAG units are presented: crown lengthening, gingivoplasty and maxillary labial frenectomy with parameters found in the in vitro pre-tests. The results showed a great decrease of the EMG activity of masseter and anterior temporalis muscles. Moreover, the height and width of the chewing cycles in the frontal plane increased after therapy. Er:YAG is able to provide good cutting and coagulation effects on soft tissues. Specific parameters have to be defined for each laser unit in order to obtain the desired effect. Reduced or absent water spray, defocused light beam, local anaesthesia and the most effective use of long pulses are methods to obtain optimal coagulation and bleeding control.

Stochastic Robust Mathematical Programming Model for Power System Optimization

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liu, Cong; Changhyeok, Lee; Haoyong, Chen

2016-01-01

This paper presents a stochastic robust framework for two-stage power system optimization problems with uncertainty. The model optimizes the probabilistic expectation of different worst-case scenarios with ifferent uncertainty sets. A case study of unit commitment shows the effectiveness of the proposed model and algorithms.

A probabilistic method for the estimation of residual risk in donated blood.

PubMed

Bish, Ebru K; Ragavan, Prasanna K; Bish, Douglas R; Slonim, Anthony D; Stramer, Susan L

2014-10-01

The residual risk (RR) of transfusion-transmitted infections, including the human immunodeficiency virus and hepatitis B and C viruses, is typically estimated by the incidence[Formula: see text]window period model, which relies on the following restrictive assumptions: Each screening test, with probability 1, (1) detects an infected unit outside of the test's window period; (2) fails to detect an infected unit within the window period; and (3) correctly identifies an infection-free unit. These assumptions need not hold in practice due to random or systemic errors and individual variations in the window period. We develop a probability model that accurately estimates the RR by relaxing these assumptions, and quantify their impact using a published cost-effectiveness study and also within an optimization model. These assumptions lead to inaccurate estimates in cost-effectiveness studies and to sub-optimal solutions in the optimization model. The testing solution generated by the optimization model translates into fewer expected infections without an increase in the testing cost. © The Author 2014. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Simultaneous quantitation of five Panax notoginseng saponins by multi heart-cutting two-dimensional liquid chromatography: Method development and application to the quality control of eight Notoginseng containing Chinese patent medicines.

PubMed

Yao, Chang-liang; Yang, Wen-zhi; Wu, Wan-Yyng; Da, Juan; Hou, Jin-jun; Zhang, Jing-xian; Zhang, Yan-hai; Jin, Yan; Yang, Min; Jiang, Bao-hong; Liu, Xuan; Guo, De-an

2015-07-10

Current China Pharmacopoeia (ChP) standards employ diversified and case-dependent assay methods to evaluate the quality of different Chinese patent medicines (CPMs) that contain Panax notoginseng as the monarch drug. These conventional, HPLC-based approaches, utilizing a complex sample preparation procedure, can easily result in low analytical efficiency and possible component loss. Here, a "monomethod-heterotrait matrix" (MHM) strategy is proposed, that is, developing a universal multi heart-cutting two-dimensional liquid chromatography (MHC-2D-LC) approach that facilitates the simultaneous quantitation of five P. notoginseng saponins (noto-R1, Re, Rg1, Rb1, and Rd) in eight different CPMs. The MHC-2D-LC system was constructed on a dual-gradient liquid chromatography instrument equipped with a Poroshell SB C18 column and a Zorbax SB-Aq column for respective (1)D and (2)D separation. Method validation was performed in terms of specificity, linearity (r(2) and F-test), intra-/inter-day precision (0.4-7.9%), stability (1.2-3.9%), and recovery (90.2-108.7%), and the LODs and LOQs (loaded masses) of the five analytes varied between 4.0-11.0ng and 6.0-33.0ng, respectively. The validated MHC-2D-LC approach was subsequently applied to quantify the five saponins in thirty batches of different CPMs. The method demonstrated superiority over the current ChP assay methods in respect of specificity (avoiding co-elution), resolution (Rs>1.5), sample preparation (easy-to-implement ultrasonic extraction without repeated re-extraction), and transfer rate (minimum component loss). This is the first application of an MHC-2D-LC method for the quantitative assessment of the constituents of CPMs. The MHM approach represents a new, strategically significant methodology for the quality control of CPMs that involve complex chemical matrix. Copyright © 2015 Elsevier B.V. All rights reserved.

Life Cycle Assessment of landfill biogas management: sensitivity to diffuse and combustion air emissions.

PubMed

Beylot, Antoine; Villeneuve, Jacques; Bellenfant, Gaël

2013-02-01

GOAL AND SCOPE: The life cycle inventory of landfill emissions is a key point in Life Cycle Assessment (LCA) of waste management options and is highly subject to discussion. Result sensitivity to data inventory is accounted for through the implementation of scenarios that help examine how waste landfilling should be modeled in LCA. Four landfill biogas management options are environmentally evaluated in a Life Cycle Assessment perspective: (1) no biogas management (open dump), conventional landfill with (2) flaring, (3) combined heat and power (CHP) production in an internal combustion engine and (4) biogas upgrading for use as a fuel in buses. Average, maximum and minimum literature values are considered both for combustion emission factors in flares and engines and for trace pollutant concentrations in biogas. Biogas upgrading for use as a fuel in buses appears as the most relevant option with respect to most non-toxic impact categories and ecotoxicity, when considering average values for trace gas concentrations and combustion emission factors. Biogas combustion in an engine for CHP production shows the best performances in terms of climate change, but generates significantly higher photochemical oxidant formation and marine eutrophication impact potentials than flaring or biogas upgrading for use as a fuel in buses. However the calculated environmental impact potentials of landfill biogas management options depend largely on the trace gas concentrations implemented in the model. The use of average or extreme values reported in the literature significantly modifies the impact potential of a given scenario (up to two orders of magnitude for open dumps with respect to human toxicity). This should be taken into account when comparing landfilling with other waste management options. Also, the actual performances of a landfill top cover (in terms of oxidation rates) and combustion technology (in terms of emission factors) appear as key parameters affecting the ranking of biogas management options. Copyright © 2012 Elsevier Ltd. All rights reserved.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wei, Max; Smith, Sarah J.; Sohn, Michael D.

Fuel cells are both a longstanding and emerging technology for stationary and transportation applications, and their future use will likely be critical for the deep decarbonization of global energy systems. As we look into future applications, a key challenge for policy-makers and technology market forecasters who seek to track and/or accelerate their market adoption is the ability to forecast market costs of the fuel cells as technology innovations are incorporated into market products. Specifically, there is a need to estimate technology learning rates, which are rates of cost reduction versus production volume. Unfortunately, no literature exists for forecasting future learningmore » rates for fuel cells. In this paper, we look retrospectively to estimate learning rates for two fuel cell deployment programs: (1) the micro-combined heat and power (CHP) program in Japan, and (2) the Self-Generation Incentive Program (SGIP) in California. These two examples have a relatively broad set of historical market data and thus provide an informative and international comparison of distinct fuel cell technologies and government deployment programs. We develop a generalized procedure for disaggregating experience-curve cost-reductions in order to disaggregate the Japanese fuel cell micro-CHP market into its constituent components, and we derive and present a range of learning rates that may explain observed market trends. Finally, we explore the differences in the technology development ecosystem and market conditions that may have contributed to the observed differences in cost reduction and draw policy observations for the market adoption of future fuel cell technologies. The scientific and policy contributions of this paper are the first comparative experience curve analysis of past fuel cell technologies in two distinct markets, and the first quantitative comparison of a detailed cost model of fuel cell systems with actual market data. The resulting approach is applicable to analyzing other fuel cell markets and other energy-related technologies, and highlights the data needed for cost modeling and quantitative assessment of key cost reduction components.« less

Co-digestion of municipal sludge and external organic wastes for enhanced biogas production under realistic plant constraints.

PubMed

Tandukar, Madan; Pavlostathis, Spyros G

2015-12-15

A bench-scale investigation was conducted to select external organic wastes and mixing ratios for co-digestion with municipal sludge at the F. Wayne Hill Water Resources Center (FWHWRC), Gwinnett County, GA, USA to support a combined heat and power (CHP) project. External wastes were chosen and used subject to two constraints: a) digester retention time no lower than 15 d; and b) total biogas (methane) production not to exceed a specific target level based on air permit constraints on CO2 emissions. Primary sludge (PS), thickened waste activated sludge (TWAS) and digested sludge collected at the FWHWRC, industrial liquid waste obtained from a chewing gum manufacturing plant (GW) and dewatered fat-oil-grease (FOG) were used. All sludge and waste samples were characterized and their ultimate digestibility was assessed at 35 °C. The ultimate COD to methane conversion of PS, TWAS, municipal sludge (PS + TWAS; 40:60 w/w TS basis), GW and FOG was 49.2, 35.2, 40.3, 72.7, and 81.1%, respectively. Co-digestion of municipal sludge with GW, FOG or both, was evaluated using four bench-scale, mesophilic (35 °C) digesters. Biogas production increased significantly and additional degradation of the municipal sludge between 1.1 and 30.7% was observed. Biogas and methane production was very close to the target levels necessary to close the energy deficit at the FWHWRC. Co-digestion resulted in an effluent quality similar to that of the control digester fed only with the municipal sludge, indicating that co-digestion had no adverse effects. Study results prove that high methane production is achievable with the addition of concentrated external organic wastes to municipal digesters, at acceptable higher digester organic loadings and lower retention times, allowing the effective implementation of CHP programs at municipal wastewater treatment plants, with significant cost savings. Copyright © 2015 Elsevier Ltd. All rights reserved.

Canopy structure of tropical and sub-tropical rain forests in relation to conifer dominance analysed with a portable LIDAR system

PubMed Central

Aiba, Shin-ichiro; Akutsu, Kosuke; Onoda, Yusuke

2013-01-01

Background and Aims Globally, conifer dominance is restricted to nutient-poor habitats in colder, drier or waterlogged environments, probably due to competition with angiosperms. Analysis of canopy structure is important for understanding the mechanism of plant coexistence in relation to competition for light. Most conifers are shade intolerant, and often have narrow, deep, conical crowns. In this study it is predicted that conifer-admixed forests have less distinct upper canopies and more undulating canopy surfaces than angiosperm-dominated forests. Methods By using a ground-based, portable light detection and ranging (LIDAR) system, canopy structure was quantified for old-growth evergreen rainforests with varying dominance of conifers along altitudinal gradients (200–3100 m a.s.l.) on tropical and sub-tropical mountains (Mount Kinabalu, Malaysian Borneo and Yakushima Island, Japan) that have different conifer floras. Key Results Conifers dominated at higher elevations on both mountains (Podocarpaceae and Araucariaceae on Kinabalu and Cupressaceae and Pinaceae on Yakushima), but conifer dominance also varied with soil/substrate conditions on Kinabalu. Conifer dominance was associated with the existence of large-diameter conifers. Forests with higher conifer dominance showed a canopy height profile (CHP) more skewed towards the understorey on both Kinabalu and Yakushima. In contrast, angiosperm-dominated forests had a CHP skewed towards upper canopy, except for lowland dipterocarp forests and a sub-alpine scrub dominated by small-leaved Leptospermum recurvum (Myrtaceae) on Kinabalu. Forests with a less dense upper canopy had more undulating outer canopy surfaces. Mixed conifer–angiosperm forests on Yakushima and dipterocarp forests on Kinabalu showed similar canopy structures. Conclusions The results generally supported the prediction, suggesting that lower growth of angiosperm trees (except L. recurvum on Kinabalu) in cold and nutrient-poor environments results in a sparser upper canopy, which allows shade-intolerant conifers to co-occur with angiosperm trees either as emergents or as codominants in the open canopy. PMID:24197751

Quantitative morphometric analysis of hepatocellular carcinoma: development of a programmed algorithm and preliminary application.

PubMed

Yap, Felix Y; Bui, James T; Knuttinen, M Grace; Walzer, Natasha M; Cotler, Scott J; Owens, Charles A; Berkes, Jamie L; Gaba, Ron C

2013-01-01

The quantitative relationship between tumor morphology and malignant potential has not been explored in liver tumors. We designed a computer algorithm to analyze shape features of hepatocellular carcinoma (HCC) and tested feasibility of morphologic analysis. Cross-sectional images from 118 patients diagnosed with HCC between 2007 and 2010 were extracted at the widest index tumor diameter. The tumor margins were outlined, and point coordinates were input into a MATLAB (MathWorks Inc., Natick, Massachusetts, USA) algorithm. Twelve shape descriptors were calculated per tumor: the compactness, the mean radial distance (MRD), the RD standard deviation (RDSD), the RD area ratio (RDAR), the zero crossings, entropy, the mean Feret diameter (MFD), the Feret ratio, the convex hull area (CHA) and perimeter (CHP) ratios, the elliptic compactness (EC), and the elliptic irregularity (EI). The parameters were correlated with the levels of alpha-fetoprotein (AFP) as an indicator of tumor aggressiveness. The quantitative morphometric analysis was technically successful in all cases. The mean parameters were as follows: compactness 0.88±0.086, MRD 0.83±0.056, RDSD 0.087±0.037, RDAR 0.045±0.023, zero crossings 6±2.2, entropy 1.43±0.16, MFD 4.40±3.14 cm, Feret ratio 0.78±0.089, CHA 0.98±0.027, CHP 0.98±0.030, EC 0.95±0.043, and EI 0.95±0.023. MFD and RDAR provided the widest value range for the best shape discrimination. The larger tumors were less compact, more concave, and less ellipsoid than the smaller tumors (P < 0.0001). AFP-producing tumors displayed greater morphologic irregularity based on several parameters, including compactness, MRD, RDSD, RDAR, entropy, and EI (P < 0.05 for all). Computerized HCC image analysis using shape descriptors is technically feasible. Aggressively growing tumors have wider diameters and more irregular margins. Future studies will determine further clinical applications for this morphologic analysis.

Enhanced sensitivity of skeletal muscle growth in offspring of mice long-term selected for high body mass in response to a maternal high-protein/low-carbohydrate diet during lactation.

PubMed

Rehfeldt, Charlotte; Langhammer, Martina; Kucia, Marzena; Nürnberg, Gerd; Metges, Cornelia C

2013-04-01

To investigate the effects of a high-protein/low-carbohydrate diet fed to mice of different genotypes during pregnancy and/or lactation on offspring skeletal muscle growth and metabolism. Pregnant mice from strains selected for high body mass (DU6) or endurance running performance (DUhLB) and from an unselected control strain (DUK) were fed iso-energetic diets containing 20 % (C) or 40 % protein and low carbohydrate (HP) from mating to weaning at day 21 of age. At birth, offspring were cross-fostered resulting in different exposure to maternal prenatal-preweaning diets (C-C, HP-C, C-HP, HP-HP). Rectus femoris muscle of male mice (n = 291) was examined at day 23, 44, 181 and 396 of age for cellular growth and metabolism. At day 23 of age, body and muscle growth was retarded by 30-40 % (P < 0.0001) in response to the C-HP and HP-HP, but not to the HP-C diet, due to reduced fibre size (P < 0.0001) but not fibre number. DNA was highly reduced in DU6, less in DUhLB, but not in DUK muscle (strain × diet; P < 0.0001). Despite some compensation, muscle growth was still impaired (P < 0.001) in adulthood (day 44; day 181), but at senescence only in DU6 mice (strain × diet; P < 0.05). Only at weaning, isocitrate and lactate dehydrogenase activities were increased or decreased (P < 0.0001), respectively, without influence on fibre type composition. A high-protein/low-carbohydrate diet fed to dams during lactation, but not during pregnancy, retards skeletal muscle growth in offspring with greater response of a heavy, obese compared with a physically fit and a control genotype and causes a transient shift towards oxidative versus glycolytic muscle metabolism.

Canopy structure of tropical and sub-tropical rain forests in relation to conifer dominance analysed with a portable LIDAR system.

PubMed

Aiba, Shin-ichiro; Akutsu, Kosuke; Onoda, Yusuke

2013-12-01

Globally, conifer dominance is restricted to nutient-poor habitats in colder, drier or waterlogged environments, probably due to competition with angiosperms. Analysis of canopy structure is important for understanding the mechanism of plant coexistence in relation to competition for light. Most conifers are shade intolerant, and often have narrow, deep, conical crowns. In this study it is predicted that conifer-admixed forests have less distinct upper canopies and more undulating canopy surfaces than angiosperm-dominated forests. By using a ground-based, portable light detection and ranging (LIDAR) system, canopy structure was quantified for old-growth evergreen rainforests with varying dominance of conifers along altitudinal gradients (200-3100 m a.s.l.) on tropical and sub-tropical mountains (Mount Kinabalu, Malaysian Borneo and Yakushima Island, Japan) that have different conifer floras. Conifers dominated at higher elevations on both mountains (Podocarpaceae and Araucariaceae on Kinabalu and Cupressaceae and Pinaceae on Yakushima), but conifer dominance also varied with soil/substrate conditions on Kinabalu. Conifer dominance was associated with the existence of large-diameter conifers. Forests with higher conifer dominance showed a canopy height profile (CHP) more skewed towards the understorey on both Kinabalu and Yakushima. In contrast, angiosperm-dominated forests had a CHP skewed towards upper canopy, except for lowland dipterocarp forests and a sub-alpine scrub dominated by small-leaved Leptospermum recurvum (Myrtaceae) on Kinabalu. Forests with a less dense upper canopy had more undulating outer canopy surfaces. Mixed conifer-angiosperm forests on Yakushima and dipterocarp forests on Kinabalu showed similar canopy structures. The results generally supported the prediction, suggesting that lower growth of angiosperm trees (except L. recurvum on Kinabalu) in cold and nutrient-poor environments results in a sparser upper canopy, which allows shade-intolerant conifers to co-occur with angiosperm trees either as emergents or as codominants in the open canopy.

An Optimization System with Parallel Processing for Reducing Common-Mode Current on Electronic Control Unit

NASA Astrophysics Data System (ADS)

Okazaki, Yuji; Uno, Takanori; Asai, Hideki

In this paper, we propose an optimization system with parallel processing for reducing electromagnetic interference (EMI) on electronic control unit (ECU). We adopt simulated annealing (SA), genetic algorithm (GA) and taboo search (TS) to seek optimal solutions, and a Spice-like circuit simulator to analyze common-mode current. Therefore, the proposed system can determine the adequate combinations of the parasitic inductance and capacitance values on printed circuit board (PCB) efficiently and practically, to reduce EMI caused by the common-mode current. Finally, we apply the proposed system to an example circuit to verify the validity and efficiency of the system.

Quantum optimal control with automatic differentiation using graphics processors

NASA Astrophysics Data System (ADS)

Leung, Nelson; Abdelhafez, Mohamed; Chakram, Srivatsan; Naik, Ravi; Groszkowski, Peter; Koch, Jens; Schuster, David

We implement quantum optimal control based on automatic differentiation and harness the acceleration afforded by graphics processing units (GPUs). Automatic differentiation allows us to specify advanced optimization criteria and incorporate them into the optimization process with ease. We will describe efficient techniques to optimally control weakly anharmonic systems that are commonly encountered in circuit QED, including coupled superconducting transmon qubits and multi-cavity circuit QED systems. These systems allow for a rich variety of control schemes that quantum optimal control is well suited to explore.

Matching soil grid unit resolutions with polygon unit scales for DNDC modelling of regional SOC pool

NASA Astrophysics Data System (ADS)

Zhang, H. D.; Yu, D. S.; Ni, Y. L.; Zhang, L. M.; Shi, X. Z.

2015-03-01

Matching soil grid unit resolution with polygon unit map scale is important to minimize uncertainty of regional soil organic carbon (SOC) pool simulation as their strong influences on the uncertainty. A series of soil grid units at varying cell sizes were derived from soil polygon units at the six map scales of 1:50 000 (C5), 1:200 000 (D2), 1:500 000 (P5), 1:1 000 000 (N1), 1:4 000 000 (N4) and 1:14 000 000 (N14), respectively, in the Tai lake region of China. Both format soil units were used for regional SOC pool simulation with DeNitrification-DeComposition (DNDC) process-based model, which runs span the time period 1982 to 2000 at the six map scales, respectively. Four indices, soil type number (STN) and area (AREA), average SOC density (ASOCD) and total SOC stocks (SOCS) of surface paddy soils simulated with the DNDC, were attributed from all these soil polygon and grid units, respectively. Subjecting to the four index values (IV) from the parent polygon units, the variation of an index value (VIV, %) from the grid units was used to assess its dataset accuracy and redundancy, which reflects uncertainty in the simulation of SOC. Optimal soil grid unit resolutions were generated and suggested for the DNDC simulation of regional SOC pool, matching with soil polygon units map scales, respectively. With the optimal raster resolution the soil grid units dataset can hold the same accuracy as its parent polygon units dataset without any redundancy, when VIV < 1% of all the four indices was assumed as criteria to the assessment. An quadratic curve regression model y = -8.0 × 10-6x2 + 0.228x + 0.211 (R2 = 0.9994, p < 0.05) was revealed, which describes the relationship between optimal soil grid unit resolution (y, km) and soil polygon unit map scale (1:x). The knowledge may serve for grid partitioning of regions focused on the investigation and simulation of SOC pool dynamics at certain map scale.

On domain symmetry and its use in homogenization

DOE PAGES

Barbarosie, Cristian A.; Tortorelli, Daniel A.; Watts, Seth E.

2017-03-08

The present study focuses on solving partial differential equations in domains exhibiting symmetries and periodic boundary conditions for the purpose of homogenization. We show in a systematic manner how the symmetry can be exploited to significantly reduce the complexity of the problem and the computational burden. This is especially relevant in inverse problems, when one needs to solve the partial differential equation (the primal problem) many times in an optimization algorithm. The main motivation of our study is inverse homogenization used to design architected composite materials with novel properties which are being fabricated at ever increasing rates thanks to recentmore » advances in additive manufacturing. For example, one may optimize the morphology of a two-phase composite unit cell to achieve isotropic homogenized properties with maximal bulk modulus and minimal Poisson ratio. Typically, the isotropy is enforced by applying constraints to the optimization problem. However, in two dimensions, one can alternatively optimize the morphology of an equilateral triangle and then rotate and reflect the triangle to form a space filling D 3 symmetric hexagonal unit cell that necessarily exhibits isotropic homogenized properties. One can further use this D 3 symmetry to reduce the computational expense by performing the “unit strain” periodic boundary condition simulations on the single triangle symmetry sector rather than the six fold larger hexagon. In this paper we use group representation theory to derive the necessary periodic boundary conditions on the symmetry sectors of unit cells. The developments are done in a general setting, and specialized to the two-dimensional dihedral symmetries of the abelian D 2, i.e. orthotropic, square unit cell and nonabelian D 3, i.e. trigonal, hexagon unit cell. We then demonstrate how this theory can be applied by evaluating the homogenized properties of a two-phase planar composite over the triangle symmetry sector of a D 3 symmetric hexagonal unit cell.« less

Perceptions of a Healthy Diet

PubMed Central

Bailey, Regan L.; Denby, Nigel; Haycock, Bryan; Sherif, Katherine; Steinbaum, Suzanne; von Schacky, Clemens

2015-01-01

Limited data exist on consumer beliefs and practices on the role of omega-3 fatty acid and vitamin D dietary supplements and health. For this reason, the Global Health and Nutrition Alliance conducted an online survey in 3 countries (n = 3030; United States = 1022, Germany = 1002, United Kingdom = 1006) of a convenience sample of adults (aged 18–66 years) who represented the age, gender, and geographic composition within each country. More than half of the sample (52%) believed they consume all the key nutrients needed for optimal nutrition through food sources alone; fewer women (48%) than men (57%), and fewer middle-aged adults (48%) than younger (18–34 years [56%]) and older (≥55 years [54%]) adults agreed an optimal diet could be achieved through diet alone. Overall, 32% reported using omega-3s (45% in United States, 29% in United Kingdom, and 24% in Germany), and 42% reported using vitamin D dietary supplements (62% in United States, 32% in United Kingdom, and 31% in Germany). Seventy eight percent of the sample agreed that omega-3 fatty acids are beneficial for heart health; however, only 40% thought that their diet was adequate in omega-3 fatty acids. Similarly, 84% agreed that vitamin D was beneficial to overall, and 55% of adults from all countries were unsure or did not think they consume enough vitamin D in their diet. For most findings in our study, US adults reported more dietary supplement use and had stronger perceptions about the health effects of omega-3s and vitamin D than their counterparts in the United Kingdom and Germany. Nevertheless, the consistent findings across all countries were that adults are aware of the importance of nutrition, and most adults believe their diet is optimal for health. Our data serve to alert dietitians and health professionals that consumers may have an elevated sense of the healthfulness of their own diets and may require guidance and education to achieve optimal diets. PMID:26663954

High quality-factor quartz tuning fork glass probe used in tapping mode atomic force microscopy for surface profile measurement

NASA Astrophysics Data System (ADS)

Chen, Yuan-Liu; Xu, Yanhao; Shimizu, Yuki; Matsukuma, Hiraku; Gao, Wei

2018-06-01

This paper presents a high quality-factor (Q-factor) quartz tuning fork (QTF) with a glass probe attached, used in frequency modulation tapping mode atomic force microscopy (AFM) for the surface profile metrology of micro and nanostructures. Unlike conventionally used QTFs, which have tungsten or platinum probes for tapping mode AFM, and suffer from a low Q-factor influenced by the relatively large mass of the probe, the glass probe, which has a lower density, increases the Q-factor of the QTF probe unit allowing it to obtain better measurement sensitivity. In addition, the process of attaching the probe to the QTF with epoxy resin, which is necessary for tapping mode AFM, is also optimized to further improve the Q-factor of the QTF glass probe. The Q-factor of the optimized QTF glass probe unit is demonstrated to be very close to that of a bare QTF without a probe attached. To verify the effectiveness and the advantages of the optimized QTF glass probe unit, the probe unit is integrated into a home-built tapping mode AFM for conducting surface profile measurements of micro and nanostructures. A blazed grating with fine tool marks of 100 nm, a microprism sheet with a vertical amplitude of 25 µm and a Fresnel lens with a steep slope of 90 degrees are used as measurement specimens. From the measurement results, it is demonstrated that the optimized QTF glass probe unit can achieve higher sensitivity as well as better stability than conventional probes in the measurement of micro and nanostructures.

PAT: predictor for structured units and its application for the optimization of target molecules for the generation of synthetic antibodies.

PubMed

Jeon, Jouhyun; Arnold, Roland; Singh, Fateh; Teyra, Joan; Braun, Tatjana; Kim, Philip M

2016-04-01

The identification of structured units in a protein sequence is an important first step for most biochemical studies. Importantly for this study, the identification of stable structured region is a crucial first step to generate novel synthetic antibodies. While many approaches to find domains or predict structured regions exist, important limitations remain, such as the optimization of domain boundaries and the lack of identification of non-domain structured units. Moreover, no integrated tool exists to find and optimize structural domains within protein sequences. Here, we describe a new tool, PAT ( http://www.kimlab.org/software/pat ) that can efficiently identify both domains (with optimized boundaries) and non-domain putative structured units. PAT automatically analyzes various structural properties, evaluates the folding stability, and reports possible structural domains in a given protein sequence. For reliability evaluation of PAT, we applied PAT to identify antibody target molecules based on the notion that soluble and well-defined protein secondary and tertiary structures are appropriate target molecules for synthetic antibodies. PAT is an efficient and sensitive tool to identify structured units. A performance analysis shows that PAT can characterize structurally well-defined regions in a given sequence and outperforms other efforts to define reliable boundaries of domains. Specially, PAT successfully identifies experimentally confirmed target molecules for antibody generation. PAT also offers the pre-calculated results of 20,210 human proteins to accelerate common queries. PAT can therefore help to investigate large-scale structured domains and improve the success rate for synthetic antibody generation.

Development of the hard and soft constraints based optimisation model for unit sizing of the hybrid renewable energy system designed for microgrid applications

NASA Astrophysics Data System (ADS)

Sundaramoorthy, Kumaravel

2017-02-01

The hybrid energy systems (HESs) based electricity generation system has become a more attractive solution for rural electrification nowadays. Economically feasible and technically reliable HESs are solidly based on an optimisation stage. This article discusses about the optimal unit sizing model with the objective function to minimise the total cost of the HES. Three typical rural sites from southern part of India have been selected for the application of the developed optimisation methodology. Feasibility studies and sensitivity analysis on the optimal HES are discussed elaborately in this article. A comparison has been carried out with the Hybrid Optimization Model for Electric Renewable optimisation model for three sites. The optimal HES is found with less total net present rate and rate of energy compared with the existing method

Identification of a Highly Transmissible Animal-Independent Staphylococcus aureus ST398 Clone with Distinct Genomic and Cell Adhesion Properties

PubMed Central

Uhlemann, Anne-Catrin; Porcella, Stephen F.; Trivedi, Sheetal; Sullivan, Sean B.; Hafer, Cory; Kennedy, Adam D.; Barbian, Kent D.; McCarthy, Alex J.; Street, Craig; Hirschberg, David L.; Lipkin, W. Ian; Lindsay, Jodi A.; DeLeo, Frank R.; Lowy, Franklin D.

2012-01-01

ABSTRACT A methicillin-resistant Staphylococcus aureus (MRSA) clone known as ST398 has emerged as a major cause of acute infections in individuals who have close contact with livestock. More recently, the emergence of an animal-independent ST398 methicillin-sensitive S. aureus (MSSA) clone has been documented in several countries. However, the limited surveillance of MSSA has precluded an accurate assessment of the global spread of ST398 and its clinical relevance. Here we provide evidence that ST398 is a frequent source of MSSA infections in northern Manhattan and is readily transmitted between individuals in households. This contrasts with the limited transmissibility of livestock-associated ST398 (LA-ST398) MRSA strains between humans. Our whole-genome sequence analysis revealed that the chromosome of the human-associated ST398 MSSA clone is smaller than that of the LA-ST398 MRSA reference strain S0385, due mainly to fewer mobile genetic elements (MGEs). In contrast, human ST398 MSSA isolates harbored the prophage φ3 and the human-specific immune evasion cluster (IEC) genes chp and scn. While most of the core genome was conserved between the human ST398 MSSA clone and S0385, these strains differed substantially in their repertoire and composition of intact adhesion genes. These genetic changes were associated with significantly enhanced adhesion of human ST398 MSSA isolates to human skin keratinocytes and keratin. We propose that the human ST398 MSSA clone can spread independent of animal contact using an optimized repertoire of MGEs and adhesion molecules adapted to transmission among humans. PMID:22375071

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shen, Bo; Lu, Hongyou; Price, Lynn K.

In the U.S., energy consumption by steam and process heat combined accounts for over 50% of the total energy use from industrial systems (see Figure 1). The use of boilers, process heaters, and furnaces for generating steam and heat in industrial facilities, commercial settings, and institutions consumes significant amounts of energy and is one of major sources of hazardous air pollutants, which contribute significantly to local pollution and global climate change. To address the energy and environmental challenges caused by boiler systems in the U.S., the country has taken a series of actions to reduce emissions from industrial, commercial andmore » institutional boilers, improve the efficiency of steam systems, replace coal with cleaner energy resources, and promote the wider use of combined heat and power (CHP).« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bluestein, J.; Horgan, S.; Eldridge, M. M.

Relatively small projects for generating electrical power at or near the point of use--distributed generation (DG)--offer unique opportunities for enhancing the U.S. electric system. This report finds that current air quality regulatory practices are inappropriately inhibiting the development of DG through a failure to recognize the environmental benefits offered by DG or by imposing requirements designed for larger systems that are not appropriate to DG systems. The report recommends that air quality regulation be made more efficient and appropriate for DG by establishing national standards for DG equipment. This report also recommends that DG projects be evaluated on a''net'' emissionsmore » basis by being given credit for any emission sources that they displace. Air quality regulation should also recognize the benefits of combined heat and power (CHP).« less

Integrated Field Testing of Fuel Cells and Micro-Turbines

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jerome R. Temchin; Stephen J. Steffel

A technical and economic evaluation of the prospects for the deployment of distributed generation on Long Beach Island, New Jersey concluded that properly sited DG would defer upgrading of the electric power grid for 10 years. This included the deployment of fuel cells or microturbines as well as reciprocating engines. The implementation phase of this project focused on the installation of a 120 kW CHP microturbine system at the Harvey Cedars Bible Conference in Harvey Cedars, NJ. A 1.1 MW generator powered by a gas-fired reciprocating engine for additional grid support was also installed at a local substation. This reportmore » contains installation and operation issues as well as the utility perspective on DG deployment.« less

Biogas and Fuel Cells Workshop Summary Report: Proceedings from the Biogas and Fuel Cells Workshop, Golden, Colorado, June 11-13, 2012

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

2013-01-01

The U.S. Department of Energy (DOE) National Renewable Energy Laboratory (NREL) held a Biogas and Fuel Cells Workshop June 11-13, 2012, in Golden, Colorado, to discuss biogas and waste-to-energy technologies for fuel cell applications. The overall objective was to identify opportunities for coupling renewable biomethane with highly efficient fuel cells to produce electricity; heat; combined heat and power (CHP); or combined heat, hydrogen and power (CHHP) for stationary or motive applications. The workshop focused on biogas sourced from wastewater treatment plants (WWTPs), landfills, and industrial facilities that generate or process large amounts of organic waste, including large biofuel production facilitiesmore » (biorefineries).« less

Optimal placement of fast cut back units based on the theory of cellular automata and agent

NASA Astrophysics Data System (ADS)

Yan, Jun; Yan, Feng

2017-06-01

The thermal power generation units with the function of fast cut back could serve power for auxiliary system and keep island operation after a major blackout, so they are excellent substitute for the traditional black-start power sources. Different placement schemes for FCB units have different influence on the subsequent restoration process. Considering the locality of the emergency dispatching rules, the unpredictability of specific dispatching instructions and unexpected situations like failure of transmission line energization, a novel deduction model for network reconfiguration based on the theory of cellular automata and agent is established. Several indexes are then defined for evaluating the placement schemes for FCB units. The attribute weights determination method based on subjective and objective integration and grey relational analysis are combinatorically used to determine the optimal placement scheme for FCB unit. The effectiveness of the proposed method is validated by the test results on the New England 10-unit 39-bus power system.

Capacity Adequacy and Revenue Sufficiency in Electricity Markets With Wind Power

DOE Office of Scientific and Technical Information (OSTI.GOV)

Levin, Todd; Botterud, Audun

2015-05-01

We present a computationally efficient mixed-integer program (MIP) that determines optimal generator expansion decisions, as well as periodic unit commitment and dispatch. The model is applied to analyze the impact of increasing wind power capacity on the optimal generation mix and the profitability of thermal generators. In a case study, we find that increasing wind penetration reduces energy prices while the prices for operating reserves increase. Moreover, scarcity pricing for operating reserves through reserve shortfall penalties significantly impacts the prices and profitability of thermal generators. Without scarcity pricing, no thermal units are profitable, however scarcity pricing can ensure profitability formore » peaking units at high wind penetration levels. Capacity payments can also ensure profitability, but the payments required for baseload units to break even increase with the amount of wind power. The results indicate that baseload units are most likely to experience revenue sufficiency problems when wind penetration increases and new baseload units are only developed when natural gas prices are high and wind penetration is low.« less

Multi-objective Optimization of a Solar Humidification Dehumidification Desalination Unit

NASA Astrophysics Data System (ADS)

Rafigh, M.; Mirzaeian, M.; Najafi, B.; Rinaldi, F.; Marchesi, R.

2017-11-01

In the present paper, a humidification-dehumidification desalination unit integrated with solar system is considered. In the first step mathematical model of the whole plant is represented. Next, taking into account the logical constraints, the performance of the system is optimized. On one hand it is desired to have higher energetic efficiency, while on the other hand, higher efficiency results in an increment in the required area for each subsystem which consequently leads to an increase in the total cost of the plant. In the present work, the optimum solution is achieved when the specific energy of the solar heater and also the areas of humidifier and dehumidifier are minimized. Due to the fact that considered objective functions are in conflict, conventional optimization methods are not applicable. Hence, multi objective optimization using genetic algorithm which is an efficient tool for dealing with problems with conflicting objectives has been utilized and a set of optimal solutions called Pareto front each of which is a tradeoff between the mentioned objectives is generated.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Thompson, Stephen R., E-mail: stephen.thompson@sesiahs.health.nsw.gov.au; Department of Radiation Oncology, Prince of Wales Hospital, Sydney; University of New South Wales, Sydney

Purpose: We aimed to estimate the optimal proportion of all gynecological cancers that should be treated with brachytherapy (BT)-the optimal brachytherapy utilization rate (BTU)-to compare this with actual gynecological BTU and to assess the effects of nonmedical factors on access to BT. Methods and Materials: The previously constructed inter/multinational guideline-based peer-reviewed models of optimal BTU for cancers of the uterine cervix, uterine corpus, and vagina were combined to estimate optimal BTU for all gynecological cancers. The robustness of the model was tested by univariate and multivariate sensitivity analyses. The resulting model was applied to New South Wales (NSW), the Unitedmore » States, and Western Europe. Actual BTU was determined for NSW by a retrospective patterns-of-care study of BT; for Western Europe from published reports; and for the United States from Surveillance, Epidemiology, and End Results data. Differences between optimal and actual BTU were assessed. The effect of nonmedical factors on access to BT in NSW were analyzed. Results: Gynecological BTU was as follows: NSW 28% optimal (95% confidence interval [CI] 26%-33%) compared with 14% actual; United States 30% optimal (95% CI 26%-34%) and 10% actual; and Western Europe 27% optimal (95% CI 25%-32%) and 16% actual. On multivariate analysis, NSW patients were more likely to undergo gynecological BT if residing in Area Health Service equipped with BT (odds ratio 1.76, P=.008) and if residing in socioeconomically disadvantaged postcodes (odds ratio 1.12, P=.05), but remoteness of residence was not significant. Conclusions: Gynecological BT is underutilized in NSW, Western Europe, and the United States given evidence-based guidelines. Access to BT equipment in NSW was significantly associated with higher utilization rates. Causes of underutilization elsewhere were undetermined. Our model of optimal BTU can be used as a quality assurance tool, providing an evidence-based benchmark against which actual patterns of practice can be measured. It can also be used to assist in determining the adequacy of BT resource allocation.« less

Study on Edge Thickening Flow Forming Using the Finite Elements Analysis

NASA Astrophysics Data System (ADS)

Kim, Young Jin; Park, Jin Sung; Cho, Chongdu

2011-08-01

This study is to examine the forming features of flow stress property and the incremental forming method with increasing the thickness of material. Recently, the optimized forming method is widely studied through the finite element analysis to optimize forming process conditions in many different forming fields. The optimal forming method should be adopted to meet geometric requirements as the reduction in volume per unit length of material such as forging, rolling, spinning etc. However conventional studies have not dealt with issue regarding volume per unit length. For the study we use the finite element method and model a gear part of an automotive engine flywheel as the study model, which is a weld assembly of a plate and a gear with respective different thickness. In simulation of the present study, a optimized forming condition for gear machining, considering the thickness of the outer edge of flywheel is studied using the finite elements analysis for the increasing thickness of the forming method. It is concluded from the study that forming method to increase the thickness per unit length for gear machining is reasonable using the finite elements analysis and forming test.

Representations of Intervals and Optimal Error Bounds.

DTIC Science & Technology

1980-07-01

OAA629-8O-C-0ONI UNCLASS I FI IEDMRC TSR-2098 NL 11111L 3 -2 11111 ~ 13.6 1111 125 .4 111.6 MCROCOPY RESOLUTION TEST CHART NATIONA’ 13UREAU OF STANDARDS...geometric and harmonic means, Excess width Work Unit Number 3 (Numerical Analysis and Computer Science) Sponsored by the United States Army under...example in the next section, following which the general theory will be dis- cussed. 3 . An example of an optimal point and error bound. A simple

A model of interaction between anticorruption authority and corruption groups

DOE Office of Scientific and Technical Information (OSTI.GOV)

Neverova, Elena G.; Malafeyef, Oleg A.

The paper provides a model of interaction between anticorruption unit and corruption groups. The main policy functions of the anticorruption unit involve reducing corrupt practices in some entities through an optimal approach to resource allocation and effective anticorruption policy. We develop a model based on Markov decision-making process and use Howard’s policy-improvement algorithm for solving an optimal decision strategy. We examine the assumption that corruption groups retaliate against the anticorruption authority to protect themselves. This model was implemented through stochastic game.

Testing the sensitivity of pumpage to increases in surficial aquifer system heads in the Cypress Creek well-field area, West-Central Florida : an optimization technique

USGS Publications Warehouse

Yobbi, Dann K.

2002-01-01

Tampa Bay depends on ground water for most of the water supply. Numerous wetlands and lakes in Pasco County have been impacted by the high demand for ground water. Central Pasco County, particularly the area within the Cypress Creek well field, has been greatly affected. Probable causes for the decline in surface-water levels are well-field pumpage and a decade-long drought. Efforts are underway to increase surface-water levels by developing alternative sources of water supply, thus reducing the quantity of well-field pumpage. Numerical ground-water flow simulations coupled with an optimization routine were used in a series of simulations to test the sensitivity of optimal pumpage to desired increases in surficial aquifer system heads in the Cypress Creek well field. The ground-water system was simulated using the central northern Tampa Bay ground-water flow model. Pumping solutions for 1987 equilibrium conditions and for a transient 6-month timeframe were determined for five test cases, each reflecting a range of desired target recovery heads at different head control sites in the surficial aquifer system. Results are presented in the form of curves relating average head recovery to total optimal pumpage. Pumping solutions are sensitive to the location of head control sites formulated in the optimization problem and as expected, total optimal pumpage decreased when desired target head increased. The distribution of optimal pumpage for individual production wells also was significantly affected by the location of head control sites. A pumping advantage was gained for test-case formulations where hydraulic heads were maximized in cells near the production wells, in cells within the steady-state pumping center cone of depression, and in cells within the area of the well field where confining-unit leakance is the highest. More water was pumped and the ratio of head recovery per unit decrease in optimal pumpage was more than double for test cases where hydraulic heads are maximized in cells located at or near the production wells. Additionally, the ratio of head recovery per unit decrease in pumpage was about three times more for the area where confining-unit leakance is the highest than for other leakance zone areas of the well field. For many head control sites, optimal heads corresponding to optimal pumpage deviated from the desired target recovery heads. Overall, pumping solutions were constrained by the limiting recovery values, initial head conditions, and by upper boundary conditions of the ground-water flow model.

Systematic design of 3D auxetic lattice materials with programmable Poisson's ratio for finite strains

NASA Astrophysics Data System (ADS)

Wang, Fengwen

2018-05-01

This paper presents a systematic approach for designing 3D auxetic lattice materials, which exhibit constant negative Poisson's ratios over large strain intervals. A unit cell model mimicking tensile tests is established and based on the proposed model, the secant Poisson's ratio is defined as the negative ratio between the lateral and the longitudinal engineering strains. The optimization problem for designing a material unit cell with a target Poisson's ratio is formulated to minimize the average lateral engineering stresses under the prescribed deformations. Numerical results demonstrate that 3D auxetic lattice materials with constant Poisson's ratios can be achieved by the proposed optimization formulation and that two sets of material architectures are obtained by imposing different symmetry on the unit cell. Moreover, inspired by the topology-optimized material architecture, a subsequent shape optimization is proposed by parametrizing material architectures using super-ellipsoids. By designing two geometrical parameters, simple optimized material microstructures with different target Poisson's ratios are obtained. By interpolating these two parameters as polynomial functions of Poisson's ratios, material architectures for any Poisson's ratio in the interval of ν ∈ [ - 0.78 , 0.00 ] are explicitly presented. Numerical evaluations show that interpolated auxetic lattice materials exhibit constant Poisson's ratios in the target strain interval of [0.00, 0.20] and that 3D auxetic lattice material architectures with programmable Poisson's ratio are achievable.

Cross-Cultural Comparison of the Effects of Optimism, Intrinsic Motivation, and Family Relations on Vocational Identity

ERIC Educational Resources Information Center

Shin, Yun-Jeong; Kelly, Kevin R.

2013-01-01

This study explored the effects of optimism, intrinsic motivation, and family relations on vocational identity in college students in the United States and South Korea. The results yielded support for the hypothesized multivariate model. Across both cultures, optimism was an important contributing factor to vocational identity, and intrinsic…

Feasibility study on optimization of a typical solar chimney power plant

NASA Astrophysics Data System (ADS)

Najmi, Mohsen; Nazari, Ali; Mansouri, Hossein; Zahedi, Ghazzanfar

2012-03-01

The solar chimney which has been built in Kerman (Kerman city-Iran) is a small scale electrical power plant. The chimney of this unit has 60 m height and 3 m diameter. The collector of this unit is 40 m × 40 m square. To reach nominal power of this unit of power plant, parameters which are effective in optimization are studied. In this regard, we deliberate and propose suggestions to maximize usage of solar energy and kinetic energy. The calculation of maximum power is one of the objectives of this study, so the paper present economic analysis for Kerman solar chimney. A home code has been written for this modeling, in MATLAB.

Ising Processing Units: Potential and Challenges for Discrete Optimization

DOE Office of Scientific and Technical Information (OSTI.GOV)

Coffrin, Carleton James; Nagarajan, Harsha; Bent, Russell Whitford

The recent emergence of novel computational devices, such as adiabatic quantum computers, CMOS annealers, and optical parametric oscillators, presents new opportunities for hybrid-optimization algorithms that leverage these kinds of specialized hardware. In this work, we propose the idea of an Ising processing unit as a computational abstraction for these emerging tools. Challenges involved in using and bench- marking these devices are presented, and open-source software tools are proposed to address some of these challenges. The proposed benchmarking tools and methodology are demonstrated by conducting a baseline study of established solution methods to a D-Wave 2X adiabatic quantum computer, one examplemore » of a commercially available Ising processing unit.« less

Family Life and Human Development: Sample Units, K-6. Revised.

ERIC Educational Resources Information Center

Prince George's County Public Schools, Upper Marlboro, MD.

Sample unit outlines, designed for kindergarten through grade six, define the content, activities, and assessment tasks appropriate to specific grade levels. The units have been extracted from the Board-approved curriculum, Health Education: The Curricular Approach to Optimal Health. The instructional guidelines for grade one are: describing a…