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Sample records for chronomodulated treatment schedules

  1. Tumor Growth Rate Determines the Timing of Optimal Chronomodulated Treatment Schedules

    PubMed Central

    Bernard, Samuel; Čajavec Bernard, Branka; Lévi, Francis; Herzel, Hanspeter

    2010-01-01

    In host and cancer tissues, drug metabolism and susceptibility to drugs vary in a circadian (24 h) manner. In particular, the efficacy of a cell cycle specific (CCS) cytotoxic agent is affected by the daily modulation of cell cycle activity in the target tissues. Anti-cancer chronotherapy, in which treatments are administered at a particular time each day, aims at exploiting these biological rhythms to reduce toxicity and improve efficacy of the treatment. The circadian status, which is the timing of physiological and behavioral activity relative to daily environmental cues, largely determines the best timing of treatments. However, the influence of variations in tumor kinetics has not been considered in determining appropriate treatment schedules. We used a simple model for cell populations under chronomodulated treatment to identify which biological parameters are important for the successful design of a chronotherapy strategy. We show that the duration of the phase of the cell cycle targeted by the treatment and the cell proliferation rate are crucial in determining the best times to administer CCS drugs. Thus, optimal treatment times depend not only on the circadian status of the patient but also on the cell cycle kinetics of the tumor. Then, we developed a theoretical analysis of treatment outcome (TATO) to relate the circadian status and cell cycle kinetic parameters to the treatment outcomes. We show that the best and the worst CCS drug administration schedules are those with 24 h intervals, implying that 24 h chronomodulated treatments can be ineffective or even harmful if administered at wrong circadian times. We show that for certain tumors, administration times at intervals different from 24 h may reduce these risks without compromising overall efficacy. PMID:20333244

  2. Chronomodulation of topotecan or X-radiation treatment increases treatment efficacy without enhancing acute toxicity

    SciTech Connect

    Mullins, Dana; Proulx, Denise; Saoudi, A.; Ng, Cheng E. . E-mail: cng@ohri.ca

    2005-05-01

    Purpose: Topotecan (TPT), a camptothecin analog, is currently used to treat human ovarian and small-cell lung cancer and is in clinical trials for other tumor sites. However, it is unknown whether chronomodulation of TPT treatment is beneficial. We examined the effects of administering TPT or X-radiation (XR) alone at different times of the day or night. Methods: We treated mice bearing human colorectal tumor xenografts at four different times representing the early rest period (9 AM or 3 HALO [hours after light onset]), late rest period (3 PM or 9 HALO), early active period (9 PM or 15 HALO), and late active period (3 AM or 21 HALO) of the mice. We gave either TPT (12 mg/kg, injected i.p.) or XR (4 Gy, directed to the tumor) twice weekly on Days 0, 4, 7, 10 within 2 weeks. Results: Treatment with either TPT or XR at 3 AM demonstrated the greatest efficacy (measured by a tumor regrowth assay) without significantly increasing acute toxicity (assessed by a decrease in leukocyte counts or body weight). Conversely, treatment at 3 PM, in particular, showed increased toxicity without any enhanced efficacy. Conclusions: Our study provided the first evidence that chronomodulation of TPT treatments, consistent with the findings of other camptothecin analogs, is potentially clinically beneficial. Additionally, our findings suggest that chronomodulation of fractionated XR treatments is also potentially clinically beneficial.

  3. Chronomodulated drug delivery system of urapidil for the treatment of hypertension

    PubMed Central

    Chaudhary, Sona S.; Patel, Hetal K.; Parejiya, Punit B.; Shelat, Pragna K.

    2015-01-01

    Introduction: Hypertension is a disease which shows circadian rhythm in the pattern of two peaks, one in the evening at about 7pm and other in the early morning between 4 am to 8 am. Conventional therapies are incapable to target those time points when actually the symptoms get worsened. To achieve drug release at two time points, chronomodulated delivery system may offer greater benefits. Materials and methods: The chronomodulated system comprised of dual approach; immediate release granules (IRG) and pulsatile release mini-tablets (PRM) filled in the hard gelatin capsule. The mini-tablets were coated using Eudragit S-100 which provided the lag time. To achieve the desired release, various parameters like coating duration and coat thickness were studied. The immediate release granules were evaluated for micromeritical properties and drug release, while mini-tablets were evaluated for various parameters such as hardness, thickness, friability, weight variation, drug content, and disintegration time and in-vitro drug release. Compatibility of drug-excipient was checked by fourier transform infrared spectroscopy and Differential scanning calorimetry studies and pellets morphology was done by Scanning electron microscopy studies. Results: The in-vitro release profile suggested that immediate release granules gives drug release within 20 min at the time of evening attack while the programmed pulsatile release was achieved from coated mini-tablets after a lag time of 9hrs, which was consistent with the demand of drug during early morning hour attack. Pellets found to be spherical in shape with smooth surface. Moreover compatibility studies illustrated no deleterious reaction between drug and polymers used in the study. Conclusions: The dual approach of developed chronomodulated formulation found to be satisfactory in the treatment of hypertension. PMID:25838996

  4. Clinical experience with chronomodulated infusional 5-fluorouracil chemoradiotherapy for pancreatic adenocarcinoma

    SciTech Connect

    Keene, Kimberly S. . E-mail: Kimberlykeene@earthlink.net; Rich, Tyvin A.; Penberthy, David R.; Shepard, Robert C.; Adams, Reid; Jones, R. Scott

    2005-05-01

    Purpose: To evaluate retrospectively the efficacy and chronic toxicities of concurrent radiotherapy and chronomodulated infusion 5-fluorouracil (5-FU) in patients with pancreatic adenocarcinoma. Methods and Materials: Twenty-eight patients with pancreatic adenocarcinoma were treated between January 1997 and May 2000 with 5-FU chronomodulated chemoradiotherapy. Chronomodulated delivery of chemotherapy was chosen on the basis of a lower toxicity profile in the treatment of GI malignancies. The median age was 64 years. Of the 28 patients, 12 were men and 16 were women. Eight patients had unresectable disease and 20 were treated after pancreatic resection. The median radiation dose was 50.4 Gy given in 28 fractions. The median field length and width was 10.6 cm and 10.9 cm, respectively. Concurrent chemotherapy with 5-FU was administered 5 d/wk, with a median total dose of 8.4 g/m{sup 2} (300 mg/m{sup 2}/d). Chronomodulated 5-FU delivery consisted of a low basal infusion for 16 h followed by an 8-h escalating-deescalating infusion peaking at 10 PM. Survival and recurrence data were evaluated using Kaplan-Meier actuarial analysis. Toxicities were recorded using the Radiation Therapy Oncology Group grading system. Results: The median follow-up for all patients was 26 months (range, 4-68 months). The median overall survival for the 20 patients treated postoperatively was 34 months, with a 3- and 5-year actuarial survival rate of 40% and 21%, respectively. If the 3 patients with carcinoma of the ampulla were removed from the data set, the mean overall survival in the resected patients was 34 months, with a 3-year and 5-year actuarial survival rate of 40% and 17%, respectively. The 8 unresectable patients had a median overall survival of 14 months, and none lived past 2 years. No patient experienced Grade 3 or 4 hematologic toxicity or weight loss. Five patients had nausea and dehydration requiring i.v. fluids; only one (4%) was hospitalized. Four patients required a dose

  5. Synergistic Effect of Combination Topotecan and Chronomodulated Radiation Therapy on Xenografted Human Nasopharyngeal Carcinoma

    SciTech Connect

    Zhang, YanLing; Chen, Xin; Ren, PeiRong; Su, Zhou; Cao, HongYing; Zhou, Jie; Zou, XiaoYan; Fu, ShaoZhi; Lin, Sheng; Fan, Juan; Yang, Bo; Sun, XiaoYang; Zhou, Yan; Chen, Yue; Yang, LingLin; Wu, JingBo

    2013-10-01

    Purpose: To investigate the in vivo chronomodulated radiosensitizing effect of topotecan (TPT) on human nasopharyngeal carcinoma (NPC) and its possible mechanisms. Methods and Materials: Xenografted BALB/c (nu/nu) NPC mice were synchronized with an alternation of 12 hours of light from 0 to 12 hours after light onset (HALO) and 12 hours of darkness to establish a unified biological rhythm. Chronomodulated radiosensitization of TPT was investigated by analysis of tumor regrowth delay (TGD), pimonidazole hydrochloride, histone H2AX phosphorylation, (γ-H2AX) topoisomerase I (Top I), cell cycle, and apoptosis after treatment with (1) TPT (10 mg/kg) alone; (2) radiation therapy alone (RT); and (3) TPT+RT at 3, 9, 15, and 21 HALO. The tumor-loaded mice without any treatment were used as controls. Results: The TPT+RT combination was more effective than TPT or RT as single agents. The TPT+RT combination at 15 HALO was best (TGD = 58.0 ± 3.6 days), and TPT+RT at 3 HALO was worst (TGD = 35.0 ± 1.5 days) among the 4 TPT+RT groups (P<.05). Immunohistochemistry analysis revealed a significantly increased histone H2AX phosphorylation expression and decreased pimonidazole hydrochloride expression in the TPT+RT group at the same time point. The results suggested that the level of tumor hypoxia and DNA damage varied in a time-dependent manner. The expression of Top I in the TPT+RT group was also significantly different from the control tumors at 15 HALO (P<.05). Cell apoptosis index was increased and the proportion of cells in S phase was decreased (P<.05) with the highest value in 15 HALO and the lowest in 3 HALO. Conclusions: This study suggested that TPT combined with chronoradiotherapy could enhance the radiosensitivity of xenografted NPC. The TPT+RT group at 15 HALO had the best therapeutic effect. The chronomodulated radiosensitization mechanisms of TPT might be related to circadian rhythm of tumor hypoxia, cell cycle redistribution, DNA damage, and expression of Top I.

  6. Design and Evaluation of Chronomodulated Drug Delivery of Tramadol Hydrochloride.

    PubMed

    Alekya, Thota; Narendar, Dudhipala; Mahipal, Donthi; Arjun, Narala; Nagaraj, Banala

    2017-09-26

    Rheumatoid arthritis is an auto immune disease which requires chronotherapy as it occurs during early morning. Tramadol hydrochloride (TH) is an analgesic drug, used to treat rheumatoid arthritis. The aim of the present investigation was to develop chronomodulated drug delivery system of tramadol hydrochloride such that it releases the drug early in the morning, during which the symptoms of rheumatoid arthritis worsen. To develop chronomodulated drug delivery system of TH, initially core tablets of TH were prepared using three different supradisintegrants followed by coating with pH dependent polymer of Eudragit S100. The prepared core tablets are evaluated for physical parameters and an optimal system was identified. Further, coating composition of Eudragit S100 was optimized and coating tablets of TH was prepared. The prepared coated tablets were evaluated for weight variation, hardness, drug content and in vitro release studies in 0.1N HCl, pH 6.8 phosphate buffer and pH 7.4 phosphate buffer. Formulation with 7.5% of coating solution (ES2) had shown a significant drug release after a lag time of 3 h (in pH 6.8 medium), 6 h (in pH 6.8 medium) and 8 h (in pH 7.4 medium), respectively. DSC studies revealed that no interaction between core and coated materials with drug was observed. Thus, chronomodulated drug delivery system of TH was formulated and assuming that if a tablet is administered around 9 pm to 10 pm, the drug release starts after a lag time of 6 h i. e., around 3am to 4 am. © Georg Thieme Verlag KG Stuttgart · New York.

  7. Chronomodulated delivery system: a tailored cap to fit different heads.

    PubMed

    Agarwal, Vaibhav; Bansal, Mayank

    2012-08-01

    "Blind race ends in a pit". A similar scenario is observed with the use of conventional dosage forms for different pathological conditions. Of late various disease states had regularly been reported to bear direct concurrence to the body's secretions that bear a constant rotationary cycle. Moreover the pharmacokinetic as well as pharmacodynamic responsiveness of various drugs had been reported to bear constant swings with the changing hours of the day. Thus, usage of the conventional zero order dosage form for every disease state or every active moiety developed, will only leave the researchers as well as the consumers in doldrums. Chronomodulated dosage forms are a silver lining in these overshadowed clouds. They are the dosage forms that spearhead the innovative researches because of their pre-programmed and pre-regulated pulsed release of the drug, at desired sites. Drug release pattern from these dosage forms considerably mimics the circadian timing of the body's secretion which are held responsible for the symptoms of the pathological irregularities arising in one's body. Thus, in a way these dosage forms are a shield against the inducers of the disease symptoms. Current review enlists the pathological states for which the chronomodulated delivery systems can prove to be a miraculous cure. This review emphasizes to summarize the patents granted as well as the novel researches undertaken by various researchers to upgrade the previously existing dosage form scenario. Moreover, this work is an attempt to summarize the various proprietary techniques and marketed formulations, thus trying to help the researchers to fabricate a better and novel dosage form from previously existing ones.

  8. Treatment of tuberculosis and optimal dosing schedules.

    PubMed

    Chang, Kwok Chiu; Leung, Chi Chiu; Grosset, Jacques; Yew, Wing Wai

    2011-11-01

    Intermittent tuberculosis treatment regimens have been developed to facilitate treatment supervision. Their efficacy has been substantiated by clinical trials and tuberculosis control programmes, notwithstanding the lack of head-to-head comparison between daily and intermittent regimens. Recently, there has been opposing evidence from observational studies, pharmacokinetic-pharmacodynamic studies and animal models that intermittent treatment increases the risk of relapse, treatment failure or acquired rifamycin resistance, especially among HIV-infected patients. Systematic reviews have been conflicting. PubMed, Ovid MEDLINE and EMBASE were systematically searched for publications in English to evaluate the evidence about dosing schedules and treatment efficacy. Levels of evidence and grades of recommendation were assigned largely according to clinical evidence with reference to the Scottish Intercollegiate Guidelines Network guideline development handbook. A total of 32 articles were included after excluding 331 ineligible articles, 42 non-analytical studies, 22 narrative reviews or expert opinions and 44 articles embedded in systematic reviews. These included 9 systematic reviews, 8 controlled studies, 9 pharmacokinetic-pharmacodynamic studies, 5 mouse studies and 1 article about guinea pig experiments. Findings suggest high levels of evidence for using daily dosing schedules, especially during the initial phase in the presence of cavitation, isoniazid resistance and advanced HIV co-infection, to reduce the risk of treatment failure, recurrence and acquired drug resistance including acquired rifamycin resistance. This review justifies the use of daily schedules in standard tuberculosis treatment regimens (particularly in the initial phase), corroborates prevailing understanding of pharmacokinetics-pharmacodynamics and mycobacterial persisters, and supports exploration of rifapentine-containing regimens in higher dosages and frequency.

  9. 7 CFR 305.23 - Steam sterilization treatment schedules.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...” air until steam vapor escapes). 1 Normal atmospheric pressure. ... Steam sterilization treatment schedules. Treatment schedule Temperature( °F) Pressure Exposure period... packages. Load with adequate spacing. Large commercial steam facilities that operate at pressures up to...

  10. Optimized Treatment Schedules for Chronic Myeloid Leukemia

    PubMed Central

    He, Qie; Dingli, David; Foo, Jasmine; Leder, Kevin Zox

    2016-01-01

    Over the past decade, several targeted therapies (e.g. imatinib, dasatinib, nilotinib) have been developed to treat Chronic Myeloid Leukemia (CML). Despite an initial response to therapy, drug resistance remains a problem for some CML patients. Recent studies have shown that resistance mutations that preexist treatment can be detected in a substantial number of patients, and that this may be associated with eventual treatment failure. One proposed method to extend treatment efficacy is to use a combination of multiple targeted therapies. However, the design of such combination therapies (timing, sequence, etc.) remains an open challenge. In this work we mathematically model the dynamics of CML response to combination therapy and analyze the impact of combination treatment schedules on treatment efficacy in patients with preexisting resistance. We then propose an optimization problem to find the best schedule of multiple therapies based on the evolution of CML according to our ordinary differential equation model. This resulting optimization problem is nontrivial due to the presence of ordinary different equation constraints and integer variables. Our model also incorporates drug toxicity constraints by tracking the dynamics of patient neutrophil counts in response to therapy. We determine optimal combination strategies that maximize time until treatment failure on hypothetical patients, using parameters estimated from clinical data in the literature. PMID:27764087

  11. 7 CFR 305.29 - Vacuum heat treatment schedule.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 5 2010-01-01 2010-01-01 false Vacuum heat treatment schedule. 305.29 Section 305.29... SERVICE, DEPARTMENT OF AGRICULTURE PHYTOSANITARY TREATMENTS Heat Treatments § 305.29 Vacuum heat treatment schedule. T111-a-1. Place bay leaves in a vacuum chamber. Starting at 0 hour, gradually reduce to 0.133...

  12. 7 CFR 305.28 - Kiln sterilization treatment schedule.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE PHYTOSANITARY TREATMENTS Heat Treatments § 305.28 Kiln sterilization treatment schedule. T404-b-4 Dry bulb temperature( °F) Wet bulb depression( °F) Percent... 7 Agriculture 5 2010-01-01 2010-01-01 false Kiln sterilization treatment schedule. 305.28...

  13. 7 CFR 305.22 - Hot water immersion treatment schedules.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 5 2010-01-01 2010-01-01 false Hot water immersion treatment schedules. 305.22... Hot water immersion treatment schedules. (a) T102-d. (1) Fruit must be grown and treated in Hawaii. (2) Fruit must be submerged at least 4 inches below the water's surface in a hot water immersion...

  14. Does chronomodulated radiotherapy improve pathological response in locally advanced rectal cancer?

    PubMed

    Squire, Tim; Buchanan, Grant; Rangiah, David; Davis, Ian; Yip, Desmond; Chua, Yu Jo; Rich, Tyvin; Elsaleh, Hany

    2017-01-01

    The predominant mode of radiation-induced cell death for solid tumours is mitotic catastrophe, which is in part dependent on sublethal damage repair being complete at around 6 h. Circadian variation appears to play a role in normal cellular division, and this could influence tumour response of radiation treatment depending on the time of treatment delivery. We tested the hypothesis that radiation treatment later in the day may improve tumour response and nodal downstaging in rectal cancer patients treated neoadjuvantly with radiation therapy. Recruitment was by retrospective review of 267 rectal cancer patients treated neoadjuvantly in the Department of Radiation Oncology at the Canberra Hospital between January 2010 and November 2015. One hundred and fifty-five patients met the inclusion criteria for which demographic, pathological and imaging data were collected, as well as the time of day patients received treatment with each fraction of radiotherapy. Data analysis was performed using the Statistical Package R with nonparametric methods of significance for all tests set at p < 0.05. Of the 45 female and 110 male patients, the median age was 64. Seventy-three percent had cT3 disease and there was a mean tumour distance from the anal verge of 7 cm. Time to surgical resection following radiotherapy ranged from 4 to 162 days with a median of 50 days, with a complete pathological response seen in 21% of patients. Patients exhibiting a favourable pathological response had smaller median pre- and postradiotherapy tumour size and had a greater change in tumour size following treatment (p < 0.01). Patients who received the majority of their radiotherapy fractions after 12:00 pm were more likely to show a complete or moderate pathological response (p = 0.035) and improved nodal downstaging. There were also more favourable responses amongst patients with longer time to surgical resection postradiotherapy (p < 0.004), although no relationship was seen between response and

  15. 7 CFR 305.25 - Dry heat treatment schedules.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 5 2010-01-01 2010-01-01 false Dry heat treatment schedules. 305.25 Section 305.25 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE PHYTOSANITARY TREATMENTS Heat Treatments § 305.25 Dry heat...

  16. 7 CFR 305.18 - Quick freeze treatment schedule.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 5 2010-01-01 2010-01-01 false Quick freeze treatment schedule. 305.18 Section 305.18 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE PHYTOSANITARY TREATMENTS Quick Freeze Treatments § 305.18 Quick...

  17. 7 CFR 305.16 - Cold treatment schedules.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 5 2010-01-01 2010-01-01 false Cold treatment schedules. 305.16 Section 305.16 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE PHYTOSANITARY TREATMENTS Cold Treatments § 305.16 Cold...

  18. 7 CFR 305.42 - Miscellaneous treatment schedules.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Miscellaneous treatment schedules. (a) T102-b, T102-b-1, T102-b-2, soapy water and wax. (1) The fruit must be... must be retreated or destroyed. (c) Three alternative treatments for plant material not tolerant to fumigation. Treatments are based on the character of the plant material and the type of pests that may be...

  19. 7 CFR 305.21 - Hot water dip treatment schedule for mangoes.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 5 2010-01-01 2010-01-01 false Hot water dip treatment schedule for mangoes. 305.21... Hot water dip treatment schedule for mangoes. Mangoes may be treated using schedule T102-a: (a) Fruit must be presorted by weight class. Treatment of mixed loads is not allowed. (b) The mangoes must...

  20. 7 CFR 305.10 - Treatment schedules for combination treatments.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... followed. (2) Normal atmospheric pressure must be used for the methyl bromide portion of the treatment. (3) In the following table, CT represents cold treatment, and MB represents methyl bromide fumigation... treatment in § 305.15 must be followed. (2) Use normal atmospheric pressure for the methyl bromide portion...

  1. 76 FR 60359 - Phytosanitary Treatments; Location of and Process for Updating Treatment Schedules; Technical...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-29

    ... Animal and Plant Health Inspection Service 7 CFR Part 305 RIN 0579-AC94 Phytosanitary Treatments; Location of and Process for Updating Treatment Schedules; Technical Amendment AGENCY: Animal and Plant... amended the phytosanitary treatment regulations by removing the lists of approved treatments and...

  2. Noncontingent reinforcement: a further examination of schedule effects during treatment.

    PubMed

    Wallace, Michele D; Iwata, Brian A; Hanley, Gregory P; Thompson, Rachel H; Roscoe, Eileen M

    2012-01-01

    We conducted 2 studies to determine whether dense and thin NCR schedules exert different influences over behavior and whether these influences change as dense schedules are thinned. In Study 1, we observed that thin as well as dense NCR schedules effectively decreased problem behavior exhibited by 3 individuals. In Study 2, we compared the effects of 2 NCR schedules in multielement designs, one with and the other without an extinction (EXT) component, while both schedules were thinned. Problem behavior remained low as the NCR schedule with EXT was thinned, but either (a) did not decrease initially or (b) subsequently increased as the NCR schedule without EXT was thinned. These results suggest that dense schedules of NCR decrease behavior by altering its motivating operation but that extinction occurs as the NCR schedule is thinned. The benefits and limitations of using dense or thin NCR schedules are discussed.

  3. 75 FR 4227 - Phytosanitary Treatments; Location of and Process for Updating Treatment Schedules

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-26

    .... 75, No. 16 / Tuesday, January 26, 2010 / Rules and Regulations#0;#0; ] DEPARTMENT OF AGRICULTURE... regulations in 7 CFR part 305 by removing the lists of approved treatments and treatment schedules from the regulations, while retaining the general requirements for performing treatments and certifying or approving...

  4. Treatment for Acquired Apraxia of Speech: Examination of Treatment Intensity and Practice Schedule

    ERIC Educational Resources Information Center

    Wambaugh, Julie L.; Nessler, Christina; Cameron, Rosalea; Mauszycki, Shannon C.

    2013-01-01

    Purpose: The authors designed this investigation to extend the development of a treatment for acquired apraxia of speech (AOS)--sound production treatment (SPT)--by examining the effects of 2 treatment intensities and 2 schedules of practice. Method: The authors used a multiple baseline design across participants and behaviors with 4 speakers with…

  5. Treatment for Acquired Apraxia of Speech: Examination of Treatment Intensity and Practice Schedule

    ERIC Educational Resources Information Center

    Wambaugh, Julie L.; Nessler, Christina; Cameron, Rosalea; Mauszycki, Shannon C.

    2013-01-01

    Purpose: The authors designed this investigation to extend the development of a treatment for acquired apraxia of speech (AOS)--sound production treatment (SPT)--by examining the effects of 2 treatment intensities and 2 schedules of practice. Method: The authors used a multiple baseline design across participants and behaviors with 4 speakers with…

  6. Noncontingent Reinforcement: A Further Examination of Schedule Effects during Treatment

    ERIC Educational Resources Information Center

    Wallace, Michelle D.; Iwata, Brian A.; Hanley, Gregory P.; Thompson, Rachel H.; Roscoe, Eileen M.

    2012-01-01

    We conducted 2 studies to determine whether dense and thin NCR schedules exert different influences over behavior and whether these influences change as dense schedules are thinned. In Study 1, we observed that thin as well as dense NCR schedules effectively decreased problem behavior exhibited by 3 individuals. In Study 2, we compared the effects…

  7. Noncontingent Reinforcement: A Further Examination of Schedule Effects during Treatment

    ERIC Educational Resources Information Center

    Wallace, Michelle D.; Iwata, Brian A.; Hanley, Gregory P.; Thompson, Rachel H.; Roscoe, Eileen M.

    2012-01-01

    We conducted 2 studies to determine whether dense and thin NCR schedules exert different influences over behavior and whether these influences change as dense schedules are thinned. In Study 1, we observed that thin as well as dense NCR schedules effectively decreased problem behavior exhibited by 3 individuals. In Study 2, we compared the effects…

  8. Variable-time reinforcement schedules in the treatment of socially maintained problem behavior.

    PubMed

    Van Camp, C M; Lerman, D C; Kelley, M E; Contrucci, S A; Vorndran, C M

    2000-01-01

    Noncontingent reinforcement (NCR) consists of delivering a reinforcer on a time-based schedule, independent of responding. Studies evaluating the effectiveness of NCR as treatment for problem behavior have used fixed-time (FT) schedules of reinforcement. In this study, the efficacy of NCR with variable-time (VT) schedules was evaluated by comparing the effects of VT and FT reinforcement schedules with 2 individuals who engaged in problem behavior maintained by positive reinforcement. Both FT and VT schedules were effective in reducing problem behavior. These findings suggest that VT schedules can be used to treat problem behavior maintained by social consequences.

  9. 7 CFR 305.3 - Processes for adding, revising, or removing treatment schedules in the PPQ Treatment Manual.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 5 2014-01-01 2014-01-01 false Processes for adding, revising, or removing treatment... TREATMENTS § 305.3 Processes for adding, revising, or removing treatment schedules in the PPQ Treatment Manual. (a) Normal process for adding, revising, or removing treatment schedules. Unless there is a...

  10. 7 CFR 305.3 - Processes for adding, revising, or removing treatment schedules in the PPQ Treatment Manual.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 5 2013-01-01 2013-01-01 false Processes for adding, revising, or removing treatment... TREATMENTS § 305.3 Processes for adding, revising, or removing treatment schedules in the PPQ Treatment Manual. (a) Normal process for adding, revising, or removing treatment schedules. Unless there is a...

  11. 7 CFR 305.26 - Khapra beetle treatment schedule for feeds and milled products.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 5 2010-01-01 2010-01-01 false Khapra beetle treatment schedule for feeds and milled products. 305.26 Section 305.26 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL... Treatments § 305.26 Khapra beetle treatment schedule for feeds and milled products. Feeds and milled products...

  12. 76 FR 3077 - Notice of Decision To Revise a Heat Treatment Schedule for Emerald Ash Borer

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-19

    ... in Myers et al. (2009) were evaluated with wet bulb depression, the experiment with heat treatment at... Animal and Plant Health Inspection Service Notice of Decision To Revise a Heat Treatment Schedule for... are advising the public of our decision to revise a heat treatment schedule for the emerald ash...

  13. 40 CFR 141.713 - Schedule for compliance with Cryptosporidium treatment requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Cryptosporidium treatment requirements. 141.713 Section 141.713 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) NATIONAL PRIMARY DRINKING WATER REGULATIONS Enhanced Treatment for Cryptosporidium Treatment Technique Requirements § 141.713 Schedule for compliance...

  14. Using Multiple Schedules during Functional Communication Training to Promote Rapid Transfer of Treatment Effects

    ERIC Educational Resources Information Center

    Fisher, Wayne W.; Greer, Brian D.; Fuhrman, Ashley M.; Querim, Angie C.

    2015-01-01

    Multiple schedules with signaled periods of reinforcement and extinction have been used to thin reinforcement schedules during functional communication training (FCT) to make the intervention more practical for parents and teachers. We evaluated whether these signals would also facilitate rapid transfer of treatment effects across settings and…

  15. Using Multiple Schedules during Functional Communication Training to Promote Rapid Transfer of Treatment Effects

    ERIC Educational Resources Information Center

    Fisher, Wayne W.; Greer, Brian D.; Fuhrman, Ashley M.; Querim, Angie C.

    2015-01-01

    Multiple schedules with signaled periods of reinforcement and extinction have been used to thin reinforcement schedules during functional communication training (FCT) to make the intervention more practical for parents and teachers. We evaluated whether these signals would also facilitate rapid transfer of treatment effects across settings and…

  16. Using Multiple Schedules During Functional Communication Training to Promote Rapid Transfer of Treatment Effects

    PubMed Central

    Fisher, Wayne W.; Greer, Brian D.; Fuhrman, Ashley M.; Querim, Angie C.

    2016-01-01

    Multiple schedules with signaled periods of reinforcement and extinction have been used to thin reinforcement schedules during functional communication training (FCT) to make the intervention more practical for parents and teachers. We evaluated whether these signals would also facilitate rapid transfer of treatment effects from one setting to the next and from one therapist to the next. With two children, we conducted FCT in the context of mixed (baseline) and multiple (treatment) schedules introduced across settings or therapists using a multiple baseline design. Results indicated that when the multiple schedules were introduced, the functional communication response came under rapid discriminative control, and problem behavior remained at near-zero rates. We extended these findings with another individual by using a more traditional baseline in which problem behavior produced reinforcement. Results replicated those of the previous participants and showed rapid reductions in problem behavior when multiple schedules were implemented across settings. PMID:26384141

  17. 7 CFR 305.9 - Aerosol spray for aircraft treatment schedule.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 5 2010-01-01 2010-01-01 false Aerosol spray for aircraft treatment schedule. 305.9 Section 305.9 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE PHYTOSANITARY TREATMENTS Chemical Treatments § 305.9...

  18. Design of Chronomodulated Drug Delivery System of Valsartan: In Vitro Characterization

    PubMed Central

    Sokar, M.; Hanafy, A.; Elkamel, A.; El-Gamal, S.

    2015-01-01

    The aim of the present study was to design and evaluate a chronomodulated time-clock pulsatile tablets of valsartan to release it after a certain lag time, independent of the gastrointestinal pH, in its absorption window to cope with the circadian rhythm of human body for blood pressure elevation. Core tablets were prepared by direct compression of a homogenous mixture of valsartan, Avicel PH101, croscarmellose sodium, magnesium stearate and Aerosil. The core tablets were then sprayed coated with a sealing layer formed of ethyl cellulose that was subsequently coated with a release-controlling layer. Three different aqueous dispersions namely; carnauba wax or beeswax or a mixture in a ratio of 2.5:1, respectively, were used to form five time-clock tablet formulations having the release controlling layer with different thickness {B5, B10, B20, BW5 and CW5}. Quality control testing were carried out to the core tablets. Differential scanning calorimetry was also performed to detect the possible drug excipient interaction in the core tablet formulation. The release was carried out, for the prepared time-clock tablet formulations, in 0.1 N hydrochloric acid for the first 2 h, followed by phosphate buffer (pH 6.8) for 4.5 h. The effect of pH on valsartan release was studied through a release study in 0.1 N hydrochloric acid for 6.5 h. Two phase dissolution study was performed to the selected time-clock tablet formulation to predict the drug permeation through the gastrointestinal tract. Stability study of the selected formula was performed at 25°/60% RH and at 40°/75% RH for 3 months. Results showed that a release-controlling layer composed of a mixture of carnauba wax and beeswax in a ratio of 2.5:1 showed a reasonable release lag time. The release lag time of the tablets increased with the increase of the coat thickness, thus B20>B10>B5 with corresponding lag time values of 4.5, 3 and 2.5 h, respectively. Selected B5 tablet formula exhibited a reasonable lag time

  19. Design of Chronomodulated Drug Delivery System of Valsartan: In Vitro Characterization.

    PubMed

    Sokar, M; Hanafy, A; Elkamel, A; El-Gamal, S

    2015-01-01

    The aim of the present study was to design and evaluate a chronomodulated time-clock pulsatile tablets of valsartan to release it after a certain lag time, independent of the gastrointestinal pH, in its absorption window to cope with the circadian rhythm of human body for blood pressure elevation. Core tablets were prepared by direct compression of a homogenous mixture of valsartan, Avicel PH101, croscarmellose sodium, magnesium stearate and Aerosil. The core tablets were then sprayed coated with a sealing layer formed of ethyl cellulose that was subsequently coated with a release-controlling layer. Three different aqueous dispersions namely; carnauba wax or beeswax or a mixture in a ratio of 2.5:1, respectively, were used to form five time-clock tablet formulations having the release controlling layer with different thickness {B5, B10, B20, BW5 and CW5}. Quality control testing were carried out to the core tablets. Differential scanning calorimetry was also performed to detect the possible drug excipient interaction in the core tablet formulation. The release was carried out, for the prepared time-clock tablet formulations, in 0.1 N hydrochloric acid for the first 2 h, followed by phosphate buffer (pH 6.8) for 4.5 h. The effect of pH on valsartan release was studied through a release study in 0.1 N hydrochloric acid for 6.5 h. Two phase dissolution study was performed to the selected time-clock tablet formulation to predict the drug permeation through the gastrointestinal tract. Stability study of the selected formula was performed at 25°/60% RH and at 40°/75% RH for 3 months. Results showed that a release-controlling layer composed of a mixture of carnauba wax and beeswax in a ratio of 2.5:1 showed a reasonable release lag time. The release lag time of the tablets increased with the increase of the coat thickness, thus B20>B10>B5 with corresponding lag time values of 4.5, 3 and 2.5 h, respectively. Selected B5 tablet formula exhibited a reasonable lag time

  20. 7 CFR 305.3 - Processes for adding, revising, or removing treatment schedules.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 5 2011-01-01 2011-01-01 false Processes for adding, revising, or removing treatment schedules. 305.3 Section 305.3 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE PHYTOSANITARY TREATMENTS § 305.3...

  1. 7 CFR 305.24 - Vapor heat treatment schedules.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... must be sized before treatment. Temperature probes must be placed in the center of the largest fruits.... Temperature probes must be placed in the center of the largest fruits. (2) The temperature of the fruit must... placed in the approximate center of the largest fruits at the seed's surface. (2) The......

  2. 7 CFR 305.27 - Forced hot air treatment schedules.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ..., and T103-d-2. (1)Temperature sensors must be inserted into the centers of the largest fruits. The number of sensors must be approved in advance by APHIS. Sensors must be physically placed in various... trays, bulk bins, or ventilated boxes) must be loaded into the treatment chamber, and sensors must be...

  3. 7 CFR 305.3 - Processes for adding, revising, or removing treatment schedules in the PPQ Treatment Manual.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 5 2012-01-01 2012-01-01 false Processes for adding, revising, or removing treatment schedules in the PPQ Treatment Manual. 305.3 Section 305.3 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE...

  4. 40 CFR 141.713 - Schedule for compliance with Cryptosporidium treatment requirements.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 24 2013-07-01 2013-07-01 false Schedule for compliance with Cryptosporidium treatment requirements. 141.713 Section 141.713 Protection of Environment ENVIRONMENTAL PROTECTION...) October 1, 2013. (4) Fewer than 10,000 people (i) October 1, 2014. a States may allow up to an additional...

  5. Itraconazole in common dermatophyte infections of the skin: fixed treatment schedules.

    PubMed

    Saul, A; Bonifaz, A

    1990-09-01

    Itraconazole is an effective medication against the most common dermatophytoses. It has been shown to be more active than griseofulvin and ketoconazole. Ease of use, affinity for keratinized tissues, lack of toxicity, continued activity after discontinuation, and the possibility of using fixed schedules are advantages of itraconazole. The fixed schedules indicated by pharmacokinetics and clinical studies are one 100 mg capsule daily for 15 days in cases of tinea corporis and tinea cruris and the same dosage for 30 days in cases of tinea pedis and tinea manuum. These fixed treatments have some limitations, and they are not recommended for treating tinea capitis and tinea unguium. The drug is well tolerated.

  6. Dose Schedule and Enhanced Conversational Recast Treatment for Children With Specific Language Impairment

    PubMed Central

    2016-01-01

    Purpose Dosage has been identified as an important element of treatment that may affect treatment efficacy. The purpose of this study was to examine the role of dose schedule for treatment of grammatical morphology deficits in children with specific language impairment (SLI). Method Sixteen 4-to-5-year-old children with SLI participated in a 5-week intervention consisting of equivalent daily Enhanced Conversational Recast treatment (Plante et al., 2014) targeting grammatical morphology. Half of the children received treatment in one 30-min session (massed condition). Half received treatment in three 10-min sessions (spaced condition) within one 4-hr period. Progress was assessed 3 times weekly by probing a child's use of his or her treatment morpheme and untreated morpheme (a maturational control) in untreated contexts. Results Pre- to posttreatment morpheme usage differed significantly for children regardless of dosage condition, and pre to post usage of an untreated morpheme was unchanged, demonstrating overall treatment efficacy. There were no differences in treatment effects for the massed and spaced conditions. Conclusions The study adds to evidence that Enhanced Conversational Recast can produce positive results in a short period of time for children with SLI. Furthermore, clinicians may have some flexibility in terms of the dose schedule they use to deliver this treatment in an evidence-based manner. PMID:27701629

  7. GnRH antagonist pre-treatment: one centre's experience for IVF-ICSI cycle scheduling.

    PubMed

    Viardot-Foucault, Veronique; Nadarajah, Sadhana; Lye, Weng Kit; Tan, Heng Hao

    2015-04-01

    Scheduling gonadotrophin-releasing hormone antagonist (GnRH-ant) cycles for IVF intracytoplasmic sperm injection in patients is a challenge because of unpredictable ovum retrieval procedures on weekends, when less manpower is available. Recently, the use of GnRH-ant pre-treatment to delay an IVF and intracytoplasmic sperm injection (ICSI) cycle showed no negative effect on clinical pregnancy rates. An age-matched, case-control study was conducted to evaluate the effectiveness of such pre-treatment for scheduling purposes. Patients (n = 140) undergoing their first ovarian stimulation for IVF-ICSI were included. Patients starting their stimulation on Tuesdays or Wednesdays were most likely to have their ovum retrieval procedure on Saturdays. Seventy patients received a 3-day course of GnRH-ant before starting stimulation, and were compared with 70 age-matched controls not receiving pre-treatment. The main outcomes were the proportion of ovum retrieval procedures occurring on Saturdays, clinical pregnancy rate and live birth rates. A five-fold reduction in the number of ovum retrievals occurred on Saturdays compared with controls (7.1% versus 34.3%; OR 0.15; 95% CI 0.05 to 0.42; P < 0.001), with no significant differences in clinical pregnancy rate (40.9% versus 37.5%) and live birth rate (27.3% versus 31.3%). GnRH-ant pre-treatment is an effective tool for scheduling of GnRH-ant cycles.

  8. Optimal treatment scheduling of ionizing radiation and sunitinib improves the antitumor activity and allows dose reduction

    PubMed Central

    Kleibeuker, Esther A; ten Hooven, Matthijs A; Castricum, Kitty C; Honeywell, Richard; Griffioen, Arjan W; Verheul, Henk M; Slotman, Ben J; Thijssen, Victor L

    2015-01-01

    The combination of radiotherapy with sunitinib is clinically hampered by rare but severe side effects and varying results with respect to clinical benefit. We studied different scheduling regimes and dose reduction in sunitinib and radiotherapy in preclinical tumor models to improve potential outcome of this combination treatment strategy. The chicken chorioallantoic membrane (CAM) was used as an angiogenesis in vivo model and as a xenograft model with human tumor cells (HT29 colorectal adenocarcinoma, OE19 esophageal adenocarcinoma). Treatment consisted of ionizing radiation (IR) and sunitinib as single therapy or in combination, using different dose-scheduling regimes. Sunitinib potentiated the inhibitory effect of IR (4 Gy) on angiogenesis. In addition, IR (4 Gy) and sunitinib (4 days of 32.5 mg/kg per day) inhibited tumor growth. Ionizing radiation induced tumor cell apoptosis and reduced proliferation, whereas sunitinib decreased tumor angiogenesis and reduced tumor cell proliferation. When IR was applied before sunitinib, this almost completely inhibited tumor growth, whereas concurrent IR was less effective and IR after sunitinib had no additional effect on tumor growth. Moreover, optimal scheduling allowed a 50% dose reduction in sunitinib while maintaining comparable antitumor effects. This study shows that the therapeutic efficacy of combination therapy improves when proper dose-scheduling is applied. More importantly, optimal treatment regimes permit dose reductions in the angiogenesis inhibitor, which will likely reduce the side effects of combination therapy in the clinical setting. Our study provides important leads to optimize combination treatment in the clinical setting. PMID:25828633

  9. A WHO study of treatment schedules for early syphilis in use throughout the world

    PubMed Central

    Willcox, R. R.

    1954-01-01

    Ten years have elapsed since penicillin was introduced in the treatment of syphilis. In order to appraise recent trends in syphilotherapy in the world, WHO carried out a detailed study of treatment practices in early syphilis. A questionnaire was circulated to leading venereologists and clinics in the world, and 277 replies were received from 55 countries giving particulars of 294 schedules. A total of 65.3% of the participants used penicillin alone and 28.9% used it in combination with other drugs. In North America all clinics relied solely on penicillin as against 52.2% in Europe; and procaine penicillin G in oil with aluminium monostearate (PAM) was used in 91% of clinics in the Americas and Asia and in 60.6% of European clinics. The most common dosage of penicillin in all stages of early syphilis was 4.8-6.0 million units; but appreciably larger doses were used in Europe than elsewhere, some 39.4% of schedules using 10.8 million units or more. There were single instances of 36 million units being given. Consolidation treatment was given in none of the North American clinics; seldom in Asia; by about one-third of the participants in Central and South America; and, for secondary syphilis, in 59% of European schedules. This study shows that with intensive treatment with PAM the saving in drug cost to clinics over the classical courses of arsenic and bismuth may be as much as £4 per case, but the overhead expenses are, of course, not reduced. PMID:13182588

  10. Developing an efficient scheduling template of a chemotherapy treatment unit: A case study.

    PubMed

    Ahmed, Z; Elmekkawy, Ty; Bates, S

    2011-01-01

    This study was undertaken to improve the performance of a Chemotherapy Treatment Unit by increasing the throughput and reducing the average patient's waiting time. In order to achieve this objective, a scheduling template has been built. The scheduling template is a simple tool that can be used to schedule patients' arrival to the clinic. A simulation model of this system was built and several scenarios, that target match the arrival pattern of the patients and resources availability, were designed and evaluated. After performing detailed analysis, one scenario provide the best system's performance. A scheduling template has been developed based on this scenario. After implementing the new scheduling template, 22.5% more patients can be served. 1. CancerCare Manitoba is a provincially mandated cancer care agency. It is dedicated to provide quality care to those who have been diagnosed and are living with cancer. MacCharles Chemotherapy unit is specially built to provide chemotherapy treatment to the cancer patients of Winnipeg. In order to maintain an excellent service, it tries to ensure that patients get their treatment in a timely manner. It is challenging to maintain that goal because of the lack of a proper roster, the workload distribution and inefficient resource allotment. In order to maintain the satisfaction of the patients and the healthcare providers, by serving the maximum number of patients in a timely manner, it is necessary to develop an efficient scheduling template that matches the required demand with the availability of resources. This goal can be reached using simulation modelling. Simulation has proven to be an excellent modelling tool. It can be defined as building computer models that represent real world or hypothetical systems, and hence experimenting with these models to study system behaviour under different scenarios.1, 2 A study was undertaken at the Children's Hospital of Eastern Ontario to identify the issues behind the long waiting

  11. [A study of recompression treatment schedule for treating type I decompression illness with medical hyperbaric chamber pressurized].

    PubMed

    Guan, Ya-dong; Wang, Zhen; Li, Dong-sheng; Fang, Yi-qun; Huang, Zhi-qiang

    2011-05-01

    To observe the therapic effects of the recompression treatment schedule D2 (breathing 100% oxygen at 0.12 MPa gauge pressure) on the type I decompression illness (DCI) by hyperbaric chamber pressurized with air. The recompression treatment schedule D2 was from the decompression treatment tables of Treatment of Illness in Compressed Air> in Germany BGI690. Seven cases on work site group (work site group) and five cases in hospital (hospital group) were treated using recompression treatment. All cases suffered from type I DCI after normal decompression procedures from working in compressed air in tunnel construction. These patients were treated with basic schedule D2 or extended schedule D2 according to the symptoms of the cases responded to recompression therapy. In the work site group, the pains of joints, arms and legs were released quickly, the therapic effects appeared at (8.1 +/- 8.1) min, the cases were cured with a recompression therapy of basic schedule D2, the total mean time of treatment was (150 +/- 0.0) min. In the hospital group, the pains of joints, arms and legs disappeared slowly, the therapic effects appeared at (115.0 +/- 60.0) min, the cases were cured with a recompression therapy of extended schedule D2, the total mean time of treatment was (270.0 +/- 0.0) min, which was significantly longer than that in the work site group (P<0.01). The treatment pressure is 0.12 MPa(gauge pressure) in schedule D2 with medical hyperbaric chamber pressurized with air,which can be used for treatment of type I DCI, the curative effects in the work site group are better than those in the hospital group.

  12. Effect of scheduled monitoring of liver function during anti-Tuberculosis treatment in a retrospective cohort in China

    PubMed Central

    2012-01-01

    Background Data on effect of regular liver function monitoring during anti-TB treatment is limited in China. This study aimed to evaluate the effects of scheduled liver function monitoring on identification of asymptomatic liver damage and anti-TB treatment outcomes during anti-TB treatment. Methods A retrospective analysis was performed based on a national-level cohort study. A total of 273 patients developing liver dysfunction were divided into two groups, 111 patients who were diagnosed through scheduled liver function test within two months after initiation of anti-TB treatment formed scheduled monitoring group, others who were diagnosed due to developing symptoms formed passive detection group (n = 162). The two groups were compared through clinical features, prognosis of liver dysfunction and impact on anti-TB treatment using propensity score weighting analysis. Results 33.3% of 273 patients did not have any clinical symptoms, including 8 with severe hepatotoxicity. 1.8% in scheduled monitoring group and 11.1% in passive detection group required hospitalization (P = 0.004). Regarding the prognosis of liver dysfunction, most patients recovered, no death happened in scheduled monitoring group while 3 died in passive detection group. In terms of impact on anti-TB treatment, 35.1% in scheduled monitoring group and 56.8% in passive detection group changed their anti-TB treatment (P = 0.001). Conclusions Scheduled monitoring is effective in identifying asymptomatic liver damage, reducing hospitalization rate and improving compliance of anti-TB treatment. PMID:22712786

  13. Methods to model and predict the ViewRay treatment deliveries to aid patient scheduling and treatment planning.

    PubMed

    Liu, Shi; Wu, Yu; Wooten, H Omar; Green, Olga; Archer, Brent; Li, Harold; Yang, Deshan

    2016-03-01

    A software tool is developed, given a new treatment plan, to predict treatment delivery time for radiation therapy (RT) treatments of patients on ViewRay magnetic resonance image-guided radiation therapy (MR-IGRT) delivery system. This tool is necessary for managing patient treatment scheduling in our clinic. The predicted treatment delivery time and the assessment of plan complexities could also be useful to aid treatment planning. A patient's total treatment delivery time, not including time required for localization, is modeled as the sum of four components: 1) the treatment initialization time; 2) the total beam-on time; 3) the gantry rotation time; and 4) the multileaf collimator (MLC) motion time. Each of the four components is predicted separately. The total beam-on time can be calculated using both the planned beam-on time and the decay-corrected dose rate. To predict the remain-ing components, we retrospectively analyzed the patient treatment delivery record files. The initialization time is demonstrated to be random since it depends on the final gantry angle of the previous treatment. Based on modeling the relationships between the gantry rotation angles and the corresponding rotation time, linear regression is applied to predict the gantry rotation time. The MLC motion time is calculated using the leaves delay modeling method and the leaf motion speed. A quantitative analysis was performed to understand the correlation between the total treatment time and the plan complexity. The proposed algorithm is able to predict the ViewRay treatment delivery time with the average prediction error 0.22 min or 1.82%, and the maximal prediction error 0.89 min or 7.88%. The analysis has shown the correlation between the plan modulation (PM) factor and the total treatment delivery time, as well as the treatment delivery duty cycle. A possibility has been identified to significantly reduce MLC motion time by optimizing the positions of closed MLC pairs. The accuracy of

  14. Methods to model and predict the ViewRay treatment deliveries to aid patient scheduling and treatment planning.

    PubMed

    Liu, Shi; Wu, Yu; Wooten, H Omar; Green, Olga; Archer, Brent; Li, Harold; Yang, Deshan

    2016-03-08

    A software tool is developed, given a new treatment plan, to predict treatment delivery time for radiation therapy (RT) treatments of patients on ViewRay magnetic resonance image-guided radiation therapy (MR-IGRT) delivery system. This tool is necessary for managing patient treatment scheduling in our clinic. The predicted treatment delivery time and the assessment of plan complexities could also be useful to aid treatment planning. A patient's total treatment delivery time, not including time required for localization, is modeled as the sum of four components: 1) the treatment initialization time; 2) the total beam-on time; 3) the gantry rotation time; and 4) the multileaf collimator (MLC) motion time. Each of the four components is predicted separately. The total beam-on time can be calculated using both the planned beam-on time and the decay-corrected dose rate. To predict the remain-ing components, we retrospectively analyzed the patient treatment delivery record files. The initialization time is demonstrated to be random since it depends on the final gantry angle of the previous treatment. Based on modeling the relationships between the gantry rotation angles and the corresponding rotation time, linear regression is applied to predict the gantry rotation time. The MLC motion time is calculated using the leaves delay modeling method and the leaf motion speed. A quantitative analysis was performed to understand the correlation between the total treatment time and the plan complexity. The proposed algorithm is able to predict the ViewRay treatment delivery time with the average prediction error 0.22min or 1.82%, and the maximal prediction error 0.89 min or 7.88%. The analysis has shown the correlation between the plan modulation (PM) factor and the total treatment delivery time, as well as the treatment delivery duty cycle. A possibility has been identified to significantly reduce MLC motion time by optimizing the positions of closed MLC pairs. The accuracy of

  15. Variable-Time Reinforcement Schedules in the Treatment of Socially Maintained Problem Behavior.

    ERIC Educational Resources Information Center

    Van Camp, Carole M.; Lerman, Dorothea C.; Kelley, Michael E.; Contrucci, Stephanie A.; Vorndran, Christina M.

    2000-01-01

    The efficacy of noncontingent reinforcement with variable-time (VT) schedules was evaluated by comparing the effects of VT and fixed-time (FT) reinforcement schedules with two individuals with moderate to severe mental retardation and severe behavior problems. Both VT and FT schedules were effective in reducing problem behavior. (Contains…

  16. 78 FR 14508 - Notice of Affirmation of Addition of a Treatment Schedule for Methyl Bromide Fumigation of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-06

    ... Treatment Schedule for Methyl Bromide Fumigation of Cottonseed AGENCY: Animal and Plant Health Inspection... methyl bromide fumigation of cottonseed for the fungal plant pathogen Fusarium oxysporum f. sp... No. APHIS- 2012-0040), announcing our determination that a new methyl bromide fumigation treatment...

  17. An Investigation of Treatment Scheduling for Phonemic Awareness with Kindergartners Who Are at Risk for Reading Difficulties

    ERIC Educational Resources Information Center

    Ukrainetz, Teresa A.; Ross, Catherine L.; Harm, Heide M.

    2009-01-01

    Purpose: This study examined 2 schedules of treatment for phonemic awareness. Method: Forty-one 5- to 6-year-old kindergartners, including 22 English learners, with low letter-name and first-sound knowledge received 11 hr of phonemic awareness treatment: concentrated (CP, 3x/wk to December), dispersed (DP, 1x/wk to March), and dispersed vocabulary…

  18. Flexible Scheduling.

    ERIC Educational Resources Information Center

    Davis, Harold S.; Bechard, Joseph E.

    A flexible schedule allows teachers to change group size, group composition, and class length according to the purpose of the lesson. This pamphlet presents various "master" schedules for flexible scheduling: (1) Simple block schedules, (2) back-to-back schedules, (3) interdisciplinary schedules, (4) school-wide block schedules, (5) open-lab…

  19. A Telemedicine Application to Schedule Temperature in an In Vivo Sensor Network for Cancer Treatment

    PubMed Central

    Kamal, Rossi; Lee, Seok-Geun

    2012-01-01

    Abstract Wireless communication has played a significant role in modern healthcare systems. However, the death toll from chronic diseases, such as cancer, continues to increase. Hyperthermia combined with radiotherapy and/or chemotherapy is a promising strategy for cancer treatment, and temperature control is critical for the success of this intervention. In vivo sensors are an emerging technology in healthcare. Thermal awareness has also received attention in in vivo sensor research. In this context, we have been motivated to use in vivo sensors to regulate the temperature changes in cancer cells during combined treatment. Limitations in existing in vivo thermal-aware routing algorithms motivated us to use the in vivo “lightweight rendezvous routing” approach. However, smartphone-driven telemedicine applications are proliferating to provide remote healthcare and collaborative consultation, required in combined therapies. In this context, we have proposed a telemedicine application where a smartphone not only regulates temperature scheduling in in vivo sensors, but also communicates with local or remote clinicians to maintain collaborative efforts for combined therapies against cancer. PMID:23234425

  20. Effects of 14-day treatment with the schedule III anorectic phendimetrazine on choice between cocaine and food in rhesus monkeys.

    PubMed

    Banks, Matthew L; Blough, Bruce E; Negus, S Stevens

    2013-08-01

    The clinical utility of monoamine releasers such as phenmetrazine or d-amphetamine as candidate agonist medications for cocaine dependence is hindered by their high abuse liability. Phendimetrazine is a clinically available schedule III anorectic that functions as a prodrug for phenmetrazine and thus may have lower abuse liability. This study determined the effects of continuous 14-day treatment with phendimetrazine on cocaine vs. food choice in rhesus monkeys (N=4). Responding was maintained under a concurrent schedule of food delivery (1-g pellets, fixed-ratio 100 schedule) and cocaine injections (0-0.1mg/kg/injection, fixed-ratio 10 schedule). Cocaine choice dose-effect curves were determined daily before and during 14-day periods of continuous intravenous treatment with saline or (+)-phendimetrazine (0.32-1.0mg/kg/h). Effects of 14-day treatment with (+)-phenmetrazine (0.1-0.32 mg/kg/h; N=5) and d-amphetamine (0.032-0.1mg/kg/h; N=6) were also examined for comparison. During saline treatment, food was primarily chosen during availability of low cocaine doses (0, 0.0032, and 0.01 mg/kg/injection), and cocaine was primarily chosen during availability of higher cocaine doses (0.032 and 0.1mg/kg/injection). Phendimetrazine initially decreased overall responding without significantly altering cocaine choice. Over the course of 14 days, tolerance developed to rate decreasing effects, and phendimetrazine dose-dependently decreased cocaine choice (significant at 0.032 mg/kg/injection cocaine). Phenmetrazine and d-amphetamine produced qualitatively similar effects. These results demonstrate that phendimetrazine can produce significant, though modest, reductions in cocaine choice in rhesus monkeys. Phendimetrazine may be especially suitable as a candidate medication for human studies because of its schedule III clinical availability. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

  1. Significance of the Bacteriophage Treatment Schedule in Reducing Salmonella Colonization of Poultry

    PubMed Central

    Bardina, Carlota; Spricigo, Denis A.; Cortés, Pilar

    2012-01-01

    Salmonella remains the major cause of food-borne diseases worldwide, with chickens known to be the main reservoir for this zoonotic pathogen. Among the many approaches to reducing Salmonella colonization of broilers, bacteriophage offers several advantages. In this study, three bacteriophages (UAB_Phi20, UAB_Phi78, and UAB_Phi87) obtained from our collection that exhibited a broad host range against Salmonella enterica serovar Enteritidis and Salmonella enterica serovar Typhimurium were characterized with respect to morphology, genome size, and restriction patterns. A cocktail composed of the three bacteriophages was more effective in promoting the lysis of S. Enteritidis and S. Typhimurium cultures than any of the three bacteriophages alone. In addition, the cocktail was able to lyse the Salmonella enterica serovars Virchow, Hadar, and Infantis. The effectiveness of the bacteriophage cocktail in reducing the concentration of S. Typhimurium was tested in two animal models using different treatment schedules. In the mouse model, 50% survival was obtained when the cocktail was administered simultaneously with bacterial infection and again at 6, 24, and 30 h postinfection. Likewise, in the White Leghorn chicken specific-pathogen-free (SPF) model, the best results, defined as a reduction of Salmonella concentration in the chicken cecum, were obtained when the bacteriophage cocktail was administered 1 day before or just after bacterial infection and then again on different days postinfection. Our results show that frequent treatment of the chickens with bacteriophage, and especially prior to colonization of the intestinal tract by Salmonella, is required to achieve effective bacterial reduction over time. PMID:22773654

  2. Total skin electron irradiation treatment for mycosis fungoides with a new alternate daily treatment schedule to minimize radiation-associated toxicity: a preliminary experience.

    PubMed

    Parida, D K; Verma, K K; Rath, G K

    2009-07-01

    Conventional total skin electron irradiation (TSEI) for mycosis fungoides (MF) causes radiation toxicity, requiring treatment interruptions that prolong the treatment period, making patient compliance poor. We evaluated an alternate daily treatment schedule of TSEI, using a high dose rate (HDR) to minimize radiation toxicity and shorten the treatment duration. Four patients (aged 45-73 years with MF duration of 7-22 months) were treated by TSEI using HDR. The treatment was given on 5 days/week for 2 weeks followed by treatment on alternate days to deliver a total dose of 36 Gy. All the patients completed treatment in 10 weeks and had complete remission. Radiation toxicity was much less common with this schedule, requiring no treatment interruption. All the patients were until in remission after 60-84 months of follow-up. This schedule of TSEI treatment caused minimal radiation toxicity and allowed completion of treatment over a shorter period, giving good clinical remission and prolonged disease-free survival.

  3. Improving liveweight gain of lambs infected by multidrug-resistant nematodes using a FECRT-based schedule of treatments.

    PubMed

    Pivoto, Felipe Lamberti; Machado, Fabricio Amadori; Anezi-Junior, Paulo Afonso; Weber, Augusto; Cezar, Alfredo Skrebsky; Sangioni, Luis Antonio; Vogel, Fernanda Silveira Flores

    2014-06-01

    The aim of this study was to compare the liveweight gain of lambs, infected by multidrug-resistant nematodes, treated by conventional schemes of helminth control or using a schedule based on fecal egg count reduction test (FECRT). The flock was selected after a FECRT (experiment 1) which revealed a parasite population resistant to benzimidazoles, imidazothiazoles, macrocyclic lactones (ivermectin), salicylanilides, nitrophenols, and organophosphates. Despite the parasite resistance to ivermectin (an avermectin), the moxidectin (a milbemycin) was effective against the gastrointestinal nematodes (PR > 90%). In experiment 2, 48 suckling lambs were distributed in four randomized blocks (G1, G2, G3, and G4) by previous body weighings. G1 was kept as untreated control; G2 was treated following a FECRT-based schedule with drugs chosen based on fecal analysis (first drench with moxidectin, second drench with a combination of moxidectin and levamisole, and third drench with praziquantel, an anti-cestode drug); G3 and G4 received three drenches with ivermectin or disophenol, respectively. Body weighings and fecal analysis of these lambs were performed every 2 weeks over a 98-day period. An effective control of gastrointestinal nematodes was obtained with two nematicidal drenches following the FECRT-based schedule of treatments. On the other hand, eggs per gram of feces (EPG) counts were no different among untreated control, G3, and G4. Lambs treated using the FECRT-based schedule had the greatest liveweight gain among the groups tested. Additionally, liveweight gain was no different among the groups G3, G4, and G1. The FECRT-based schedule of anthelmintic treatments was beneficial regarding productivity and sustainability of helminth control in lambs infected by multidrug-resistant nematodes.

  4. Combining noncontingent reinforcement and differential reinforcement schedules as treatment for aberrant behavior.

    PubMed

    Marcus, B A; Vollmer, T R

    1996-01-01

    Research has shown that noncontingent reinforcement (NCR) can be an effective behavior-reduction procedure when based on a functional analysis. The effects of NCR may be a result of elimination of the contingency between aberrant behavior and reinforcing consequences (extinction) or frequent and free access to reinforcers that may reduce the participant's motivation to engage in aberrant behaviors or mands. If motivation is momentarily reduced, behavior such as mands may not be sensitive to positive reinforcement. In this study, for 3 children with aberrant behavior maintained by tangible positive reinforcement, differential-reinforcement-of-alternative-behavior schedules were superimposed on NCR schedules to determine if mands could be strengthened. Results for the participants indicated that NCR did not preclude reinforcement of mands.

  5. Early Mucosal Reactions During and After Head-and-Neck Radiotherapy: Dependence of Treatment Tolerance on Radiation Dose and Schedule Duration

    SciTech Connect

    Fenwick, John D. Lawrence, Geoff P.; Malik, Zafar; Nahum, Alan E.; Mayles, W. Philip M.

    2008-06-01

    Purpose: To more precisely localize the dose-time boundary between head-and-neck radiotherapy schedules inducing tolerable and intolerable early mucosal reactions. Methods and Materials: Total cell-kill biologically effective doses (BED{sub CK}) have been calculated for 84 schedules, including incomplete repair effects, but making no other corrections for the effect of schedule duration T. [BED{sub CK},T] scatterplots are graphed, overlying BED{sub CKboundary}(T) curves on the plots and using discriminant analysis to optimize BED{sub CKboundary}(T) to best represent the boundary between the tolerable and intolerable schedules. Results: More overlap than expected is seen between the tolerable and intolerable treatments in the 84-schedule [BED{sub CK},T] scatterplot, but this was largely eliminated by removing gap and tolerated accelerating schedules from the plot. For the remaining 57 predominantly regular schedules, the BED{sub CKboundary}(T) boundary increases with increasing T (p = 0.0001), curving upwards significantly nonlinearly (p = 0.00007) and continuing to curve beyond 15 days (p = 0.035). The regular schedule BED{sub CKboundary}(T) boundary does not describe tolerability well for accelerating schedules (p = 0.002), with several tolerated accelerating schedules lying above the boundary where regular schedules would be intolerable. Gap schedule tolerability also is not adequately described by the regular schedule boundary (p = 0.04), although no systematic offset exists between the regular boundary and the overall gap schedule tolerability pattern. Conclusions: All schedules analyzed (regular, gap, and accelerating) with BED{sub CK} values below BED{sub CKboundary}(T)=69.5x(T/32.2)/sin((T/32.2){sup (radians)})-3.5Gy= {sub 10}(forT{<=}50 days) are tolerable, and many lying above the boundary are intolerable. The accelerating schedules analyzed were tolerated better overall than are the regular schedules with similar [BED{sub CK},T] values.

  6. Enhancing the activity of cannabidiol and other cannabinoids in vitro through modifications to drug combinations and treatment schedules.

    PubMed

    Scott, Katherine Ann; Shah, Sini; Dalgleish, Angus George; Liu, Wai Man

    2013-10-01

    Cannabinoids are the bioactive components of the Cannabis plant that display a diverse range of therapeutic qualities. We explored the activity of six cannabinoids, used both alone and in combination in leukaemic cells. Cannabinoids were cytostatic and caused a simultaneous arrest at all phases of the cell cycle. Re-culturing pre-treated cells in drug-free medium resulted in dramatic reductions in cell viability. Furthermore, combining cannabinoids was not antagonistic. We suggest that the activities of some cannabinoids are influenced by treatment schedules; therefore, it is important to carefully select the most appropriate strategy in order to maximise their efficacy.

  7. An investigation of treatment scheduling for phonemic awareness with kindergartners who are at risk for reading difficulties.

    PubMed

    Ukrainetz, Teresa A; Ross, Catherine L; Harm, Heide M

    2009-01-01

    This study examined 2 schedules of treatment for phonemic awareness. Forty-one 5- to 6-year-old kindergartners, including 22 English learners, with low letter-name and first-sound knowledge received 11 hr of phonemic awareness treatment: concentrated (CP, 3x/wk to December), dispersed (DP, 1x/wk to March), and dispersed vocabulary control (CON). English learners performed similarly to native English speakers. Participants with moderate deficits in letter-names and first sounds showed significant benefits after both treatment conditions. Three times the intensity had no additional effect on phonemic awareness. CP continued to increase significantly during the no-treatment interval. In March, CP and DP were significantly greater than CON, but the 2 conditions did not differ other than with a minor DP advantage on last sounds. By May, there were no significant differences among the 3 conditions in meeting grade-level expectations for phoneme segmenting. For phonemic awareness, over the course of a school year, with concomitant classroom instruction, the gains made from short, intense treatment were similar to those made from continuous weekly treatment. At-risk kindergartners with moderate deficits benefited more than those with mild deficits. Children, particularly those with mild deficits, may improve substantially with only classroom instruction and incidental self-regulatory gains from treatment for another area.

  8. Behavioral Interventions in the Treatment of Pathological Gambling: A Review of Activity Scheduling and Desensitization

    ERIC Educational Resources Information Center

    Dowling, Nicki; Jackson, Alun C.; Thomas, Shane A.

    2008-01-01

    Cognitive and behavioral interventions have been cautiously recommended as "best practice" in the treatment of pathological gambling. Behavioral interventions, using a range of techniques, have been the most commonly evaluated approach to the psychological treatment of pathological gambling. The recent literature evaluating behavioral treatments…

  9. The effects of fixed-time reinforcement schedules on problem behavior of children with emotional and behavioral disorders in a day-treatment classroom setting.

    PubMed

    Rasmussen, Karina; O'Neill, Robert E

    2006-01-01

    The current study assessed the effects of fixed-time reinforcement schedules on problem behavior of students with emotional-behavioral disorders in a clinical day-treatment classroom setting. Three elementary-aged students with a variety of emotional and behavioral problems participated in the study. Initial functional assessments indicated that social attention was the maintaining reinforcer for their verbally disruptive behavior. Baseline phases were alternated with phases in which attention was provided on fixed-time schedules in the context of an ABAB design. The results indicated that the provision of attention on fixed-time schedules substantially reduced the participants' rate of verbal disruptions. These decreases were maintained during initial thinning of the schedules. The results provide one of the first examples that such an intervention can be successfully implemented in a classroom setting.

  10. The Cost of Inpatient Care of Schizophrenia and Treatment Schedules Used in German Academic Center: Kiel.

    PubMed

    Zaprutko, Tomasz; Göder, Robert; Kus, Krzysztof; Rakhman, Lyudmyla; Bilobryvka, Rostyslav; Nowakowska, Elżbieta

    2016-12-01

    The authors aimed at analyzing the costs of inpatient care of schizophrenia in Kiel (Germany). The study was also to present treatment regimens used at the German Academic Center. Moreover, the study is a continuation and complement of the previous study conducted in Polish and Ukrainian Academic Center. Therefore, it helps increase the awareness and knowledge of residents concerning the cost of inpatient care of schizophrenia. The analysis was based on 105 hospital records of patients treated between January 2012 and June 2013. According to inclusion criteria, 50 adult patients (27 women and 23 men) were included in the study. The study was approved by the Ethics Committee of the Medicine Faculty of CAU in Kiel. The cost of schizophrenia treatment of 50 patients in Kiel was EUR 604,280.90 ([Formula: see text] = EUR 12,085.62). The duration of hospital stay was on average [Formula: see text] = 51.02 days. The patients were treated with neuroleptics of all generations. The most popular atypical neuroleptic was amisulpride and the most popular typical neuroleptic was haloperidol. Patients from Kiel were provided a comprehensive non-pharmacological treatment. Treatment regiments and evaluations of costs of schizophrenia vary between countries. The costs of inpatient care of schizophrenia are high in Kiel. Treatment of schizophrenia seems to be comprehensive in Kiel and wide range of treatment opportunities contribute to a more effective treatment confirmed by less frequent relapses of schizophrenia than in Lviv (Ukraine), for example. Comprehensive treatment should be available everywhere, because it is a right of every patient.

  11. Development of phytosanitary cold treatments for oranges infested with Bactrocera invadens and Bactrocera zonata (Diptera: Tephritidae) by comparison with existing cold treatment schedules for Ceratitis capitata (Diptera: Tephritidae).

    PubMed

    Hallman, Guy J; Myers, Scott W; El-Wakkad, Mokhtar F; Tadrous, Meshil D; Jessup, Andrew J

    2013-08-01

    Phytosanitary cold treatments were tested for Bactrocera invadens Drew, Tsuruta, and White and Bactrocera zonata (Saunders) using comparisons with Ceratitis capitata (Wiedemann). Oranges were infested by puncturing holes in the peel and allowing tephritids to oviposit in the holes. The treatments were initiated when the larvae reached late third instar because previous research had shown that stage to be the most cold tolerant for all three species. Results show that B. invadens is not more cold tolerant than C. capitata and B. zonata at 1.0 +/- 0.1 degrees C and lend support to the use of C. capitata cold treatment schedules for B. invadens. It cannot be concluded that B. zonata is not more cold tolerant than C. capitata.

  12. Impact of proton beam availability on patient treatment schedule in radiation oncology.

    PubMed

    Miller, Eric D; Derenchuk, Vladimir; Das, Indra J; Johnstone, Peter A S

    2012-11-08

    Proton beam therapy offers unique physical properties with potential for reduced toxicity and better patient care. There is an increased interest in radiation oncology centers to acquire proton therapy capabilities. The operation of a proton treatment center is quite different than a photon-based clinic because of the more complex technology involved, as well as the single proton beam source serving multiple treatment rooms with no backup source available. There is limited published data which investigates metrics that can be used to determine the performance of a proton facility. The purpose of this study is to evaluate performance metrics of Indiana University Cyclotron Operations (IUCO), including availability, mean time between failures, and mean time to repair, and to determine how changes in these metrics impact patient treatments. We utilized a computerized maintenance management system to log all downtime occurrences and servicing operations for the facility. These data were then used to calculate the availability as well as the mean time between failures and mean time to repair. Impact on patient treatments was determined by analyzing delayed and missed treatments, which were recorded in an electronic medical record and database maintained by the therapists. The availability of the IUCO proton beam has been increasing since beginning of operation in 2003 and averaged 96.9% for 2009 through 2011. The mean time between failures and mean time to repair were also determined and correlated with improvements in the maintenance and operating procedures of the facility, as well as environmental factors. It was found that events less than 15 minutes in duration have minimal impact on treatment delays, while events lasting longer than one hour may result in missed treatments. The availability of the proton beam was more closely correlated with delayed than with missed treatments, demonstrating the utility and limitations of the availability metric. In conclusion, we

  13. Evaluation of heat treatment schedules for emerald ash borer (Coleoptera: Buprestidae).

    PubMed

    Myers, Scott W; Fraser, Ivich; Mastro, Victor C

    2009-12-01

    The thermotolerance of the emerald ash borer, Agrilus planipennis Fairmaire (Coleoptera: Buprestidae), was evaluated by subjecting larvae and prepupae to a number of time-temperature regimes. Three independent experiments were conducted during 2006 and 2007 by heating emerald ash borer infested firewood in laboratory ovens. Heat treatments were established based on the internal wood temperature. Treatments ranged from 45 to 65 degrees C for 30 and 60 min, and the ability of larvae to pupate and emerge as adults was used to evaluate the success of each treatment. A fourth experiment was conducted to examine heat treatments on exposed prepupae removed from logs and subjected to ambient temperatures of 50, 55, and 60 degrees C for 15, 30, 45, and 60 min. Results from the firewood experiments were consistent in the first experiment. Emergence data showed emerald ash borer larvae were capable of surviving a temperatures-time combination up to 60 degrees C for 30 min in wood. The 65 degrees C for 30 min treatment was, however, effective in preventing emerald ash borer emergence on both dates. Conversely, in the second experiment using saturated steam heat, complete mortality was achieved at 50 and 55 degrees C for both 30 and 60 min. Results from the prepupae experiment showed emerald ash borer survivorship in temperature-time combinations up to 55 degrees C for 30 min, and at 50 degrees C for 60 min; 60 degrees C for 15 min and longer was effective in preventing pupation in exposed prepupae. Overall results suggest that emerald ash borer survival is variable depending on heating conditions, and an internal wood temperature of 60 degrees C for 60 min should be considered the minimum for safe treatment for firewood.

  14. Palliative radiotherapy fractionation schedules prescribed are dependent on the distance a patient travels to receive treatment.

    PubMed

    Barnes, Mark; Tiwana, Manpreet S; Miller, Stacy; Kiraly, Andrew; Olivotto, Ivo A; Emmons, Scott; Olson, Robert A

    2015-11-01

    This study assessed the impact of the distance a patient travelled to the treatment centre on the use of single fraction RT for bone metastases. There was significant variability in the prescription of SFRT by distance at which the patient lives from a cancer centre (p<0.001).

  15. 40 CFR 141.713 - Schedule for compliance with Cryptosporidium treatment requirements.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... the bin classification for a filtered system changes following the second round of source water... AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) NATIONAL PRIMARY DRINKING WATER REGULATIONS Enhanced... Cryptosporidium treatment requirements. (a) Following initial bin classification under § 141.710(c), filtered...

  16. 40 CFR 141.713 - Schedule for compliance with Cryptosporidium treatment requirements.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... the bin classification for a filtered system changes following the second round of source water... AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) NATIONAL PRIMARY DRINKING WATER REGULATIONS Enhanced... Cryptosporidium treatment requirements. (a) Following initial bin classification under § 141.710(c), filtered...

  17. 40 CFR 141.713 - Schedule for compliance with Cryptosporidium treatment requirements.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... the bin classification for a filtered system changes following the second round of source water... AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) NATIONAL PRIMARY DRINKING WATER REGULATIONS Enhanced... Cryptosporidium treatment requirements. (a) Following initial bin classification under § 141.710(c), filtered...

  18. Effect of source, drying method and treatment schedule on treatability of red pine

    Treesearch

    Stan Lebow; Cherilyn Hatfield; Steve Halverson

    2006-01-01

    Although sapwood of pine species is generally considered to be readily treated with preservatives, penetration is sometimes variable. The cause of this variability is poorly understood. This study evaluated the effect of geographic source, method of drying, and treatment parameters on penetration of a preservative in red pine lumber. Lumber from Wisconsin and Michigan...

  19. Accelerated immunotherapy schedules.

    PubMed

    Calabria, Christopher W

    2013-08-01

    Rush and cluster immunotherapy schedules are accelerated immunotherapy build-up schedules. A cluster immunotherapy schedule involves the patient receiving several allergen injections (generally 2-4) sequentially in a single day of treatment on nonconsecutive days. The maintenance dose is generally reached in 4-8 weeks. In rush immunotherapy protocols, higher doses are administered at 15- to 60-min intervals over a 1- to 3-day period until the maintenance dose is achieved. This review will serve as an update for accelerated immunotherapy schedules. The review will include recent investigations demonstrating the safety of cluster schedules in atopic dermatitis, pediatric patients, and inhalant allergen mixtures and an accelerated protocol utilizing an infusion pump for allergen delivery. There has also been further elucidation on the immunological changes which occur during accelerated immunotherapy. Finally, new studies analyzing systemic reaction risk factors are discussed.

  20. Combination therapy for Cushing's disease: effectiveness of two schedules of treatment: should we start with cabergoline or ketoconazole?

    PubMed

    Barbot, M; Albiger, N; Ceccato, F; Zilio, M; Frigo, A C; Denaro, L; Mantero, F; Scaroni, C

    2014-04-01

    Cushing's disease (CD) is associated with increased morbidity and mortality. Until now, no medical treatment has been shown to be totally satisfactory when administrated alone. This study aimed to assess the effectiveness of cabergoline with added ketoconazole and of the same combination in reverse, using urinary free cortisol (UFC) and late night salivary cortisol (LNSC) levels as biochemical markers of the treatments' efficacy in CD patients. A prospective analysis conducted on 14 patients (f/m = 12/2; median age 52, range 33-70 years) divided into two groups: 6 patients initially treated with cabergoline for 4-6 months (rising from 0.5-1 mg/week up to 3.0 mg/week), after which ketoconazole was added (group A); and 8 patients first took ketoconazole alone for 4-6 months (rising from 200 mg/day to 600 mg/day), then cabergoline was added (group B). Patients were compared with 14 age-matched patients in prolonged remission after effective neurosurgery for CD. The combination therapy led to UFC normalization in 79 % of patients with no differences between the groups; only one patient failed to respond at all. Neither drug succeeded in controlling the disease when taken alone. LNSC dropped when compared to baseline levels, but not to a significant degree (p = 0.06), and it remained significantly higher than in controls (p = 0.0006). Associating cabergoline with ketoconazole may represent an effective second-line treatment, achieving a satisfactory reduction in UFC levels and clinical improvement. Although the combined treatment lowered patients' LNSC levels, they remained higher than normal, indicating a persistent subclinical hypercortisolism; the implications of this condition need to be considered. No differences emerged between the two treatment schedules.

  1. Making molehills out of a mountain: experience with a new scheduling strategy to diminish workload variations in response to increased treatment demands

    PubMed Central

    Waters, A.; Alizadeh, M.; Filion, C.; Ashbury, F.; Pun, J.; Chagnon, M.P.; Legrain, A.; Fortin, M.A.

    2016-01-01

    Purpose A new scheduling strategy was implemented. Before implementation, treatments and planning computed tomography (ct) imaging were both scheduled at the same time. Maximal wait times for treatment are defined by the Quebec Ministry of Health’s plan of action according to treatment aim and site. After implementation, patients requiring rapid treatment (priorities 0–3) continued to have their treatments scheduled at the same time as their planning ct; treatments for priority 4 (P4) patients were scheduled only after the treatment plan was approved. That approach aims to compensate for unexpected increases in planning workload by relocating less delay-sensitive cases to other time slots. We evaluated the impact on the patient experience, workload in various sectors, the care team’s perception of care delivery, access to care, and the department’s efficiency in terms of hours worked per treatment delivered. Methods Three periods were defined for analysis: the pre-transitional phase, for baseline evaluation; the transitional phase, during which there was an overlap in the way patients were being scheduled; and the post-transitional phase. Wait times were calculated from the date that patients were ready to treat to the date of their first treatment. Surveys were distributed to pre- and post-transitional phase patients. Care team members were asked to complete a survey evaluating their perception of how the change affected workload and patient care. Operational data were analyzed. Results We observed a 24% increase in the number of treatments delivered in the post-transitional phase. Before implementation, priority 0–3 patients waited a mean of 7.9 days to begin treatments (n = 241); afterward, they waited 6.3 days (n = 340, p = 0.006). Before implementation, P4 patients waited a mean 15.1 days (n = 233); after implementation, they waited 16.1 days (n = 368, p = 0.22). Surveys showed that patients felt that the time it took to inform them of treatment

  2. Scheduling Supercomputers.

    DTIC Science & Technology

    1983-02-01

    no task is scheduled with overlap. Let numpi be the total number of preemptions and idle slots of size at most to that are introduced. We see that if...no usable block remains on Qm-*, then numpi < m-k. Otherwise, numpi ! m-k-1. If j>n when this procedure terminates, then all tasks have been scheduled

  3. Composite Scheduling

    ERIC Educational Resources Information Center

    Childers, Gary L.; Ireland, Rebecca Weeks

    2005-01-01

    In education, there is no one best way to do anything. There are compelling reasons why some courses should be taught in longer segments of time, which the block schedule provides. There are also compelling reasons why some classes should be taught in shorter segments. At Watauga High School in Boone, North Carolina, an alternative schedule that…

  4. Scheduling game

    SciTech Connect

    Kleck, W

    1982-04-01

    Structuring a schedule - whether by Critical Path Method (CPM) or Precedence Charting System (PCS) - involves estimating the duration of one or more activities and arranging them in the most logical sequence. Given the start date, the completion date is relatively simple to determine. What is then so complicated about the process. It is complicated by the people involved - the people who make the schedules and the people who attempt to follow them. Schedules are an essential part of project management and construction contract administration. Much of the material available pertains to the mechanics of schedules, the types of logic networks, the ways that data can be generated and presented. This paper sheds light on other facets of the subject - the statistical and philosophical fundamentals involved in scheduling.

  5. A Comparison of Five Reinforcement Schedules for Use in Contingency Management-Based Treatment of Methamphetamine Abuse

    ERIC Educational Resources Information Center

    Roll, John M.; Huber, Alice; Sodano, Ruthlyn; Chudzynski, Joy E.; Moynier, Eugene; Shoptaw, Steve

    2006-01-01

    One variation of contingency management involves providing vouchers with monetary value for the provision of a biological sample indicating no recent drug use. These vouchers can be exchanged for goods or services. The schedule with which the vouchers are disbursed has been studied and results suggest that those schedules that incorporate…

  6. Effects of On-Demand Versus Fixed-Interval Schedules in the Treatment of Chronic Pain With Analgesic Compounds.

    ERIC Educational Resources Information Center

    Berntzen, Dagfinn; Gotestam, K. Gunnar

    1987-01-01

    Compared the effects of fixed-interval and on-demand administration of analgesic medications in chronic pain patients. A fixed-interval analgesic schedule was found more effective than an on-demand schedule in reducing subjective pain and elevating mood. No differences were found between the two conditions on measures of physical activity.…

  7. A Comparison of Five Reinforcement Schedules for Use in Contingency Management-Based Treatment of Methamphetamine Abuse

    ERIC Educational Resources Information Center

    Roll, John M.; Huber, Alice; Sodano, Ruthlyn; Chudzynski, Joy E.; Moynier, Eugene; Shoptaw, Steve

    2006-01-01

    One variation of contingency management involves providing vouchers with monetary value for the provision of a biological sample indicating no recent drug use. These vouchers can be exchanged for goods or services. The schedule with which the vouchers are disbursed has been studied and results suggest that those schedules that incorporate…

  8. Effects of On-Demand Versus Fixed-Interval Schedules in the Treatment of Chronic Pain With Analgesic Compounds.

    ERIC Educational Resources Information Center

    Berntzen, Dagfinn; Gotestam, K. Gunnar

    1987-01-01

    Compared the effects of fixed-interval and on-demand administration of analgesic medications in chronic pain patients. A fixed-interval analgesic schedule was found more effective than an on-demand schedule in reducing subjective pain and elevating mood. No differences were found between the two conditions on measures of physical activity.…

  9. The Use of Descriptive Analysis to Identify and Manipulate Schedules of Reinforcement in the Treatment of Food Refusal

    ERIC Educational Resources Information Center

    Casey, Sean D.; Cooper-Brown, Linda J.; Wacker, David P.; Rankin, Barbara E.

    2006-01-01

    The feeding behaviors of a child diagnosed with failure to thrive were assessed using descriptive analysis methodology to identify the schedules of reinforcement provided by the child's parents. This analysis revealed that the child's appropriate feeding behaviors (i.e., bite acceptance, self-feeding) were on a lean schedule of positive…

  10. Mission scheduling

    NASA Technical Reports Server (NTRS)

    Gaspin, Christine

    1989-01-01

    How a neural network can work, compared to a hybrid system based on an operations research and artificial intelligence approach, is investigated through a mission scheduling problem. The characteristic features of each system are discussed.

  11. Effect of treatment in fractionated schedules with the combination of x-irradiation and six cytotoxic drugs on the RIF-1 tumor and normal mouse skin

    SciTech Connect

    Lelieveld, P.; Scoles, M.A.; Brown, J.M.; Phil, D.; Kallman, R.F.

    1985-01-01

    RIF-1 tumors, implanted syngeneically in the gastrocnemius muscles of the right hind legs of C3H/Km mice, were treated either with X ray alone, drug alone, or drug and X ray combined. The drugs tested were bleomycin, BCNU, cis-diamminedichloro platinum, adriamycin, cyclophosphamide, and actinomycin-D. All drugs were administered either in the maximum tolerated dose or a dose that causes minimal tumor growth delay. Both drugs and X rays were administered either as a single dose or in five daily fractions. In addition to the single modality controls, seven different schedules of combined modalities were tested. Tumors were measured periodically after treatment in order that the day at which each tumor reached 4 times its initial cross-sectional area, i.e., its size at the time of treatment, could be determined. The effect of treatment on tumors was based upon excess growth delay (GD), i.e., T400% (treated)-T400% (untreated control). Treatment effects for the same combined modality schedules were also determined for normal skin, using the early skin reaction as an endpoint. Dose effect factors (DEF) were computed for all combined modality schedules and were based upon calculated radiation dose equivalents. We also calculated supra-additivity ratios, SR/sub I/ and SR/sub II/, therapeutic gain factors and adjusted therapeutic gain factors. The only drugs to produce significant supra-additivity with X rays were cis-Pt and cyclo.

  12. Scheduling algorithms

    NASA Astrophysics Data System (ADS)

    Wolfe, William J.; Wood, David; Sorensen, Stephen E.

    1996-12-01

    This paper discusses automated scheduling as it applies to complex domains such as factories, transportation, and communications systems. The window-constrained-packing problem is introduced as an ideal model of the scheduling trade offs. Specific algorithms are compared in terms of simplicity, speed, and accuracy. In particular, dispatch, look-ahead, and genetic algorithms are statistically compared on randomly generated job sets. The conclusion is that dispatch methods are fast and fairly accurate; while modern algorithms, such as genetic and simulate annealing, have excessive run times, and are too complex to be practical.

  13. A cloud-based electronic medical record for scheduling, tracking, and documenting examinations and treatment of retinopathy of prematurity.

    PubMed

    Arnold, Robert W; Jacob, Jack; Matrix, Zinnia

    2012-01-01

    Screening by neonatologists and staging by ophthalmologists is a cost-effective intervention, but inadvertent missed examinations create a high liability. Paper tracking, bedside schedule reminders, and a computer scheduling and reminder program were compared for speed of input and retrospective missed examination rate. A neonatal intensive care unit (NICU) process was then programmed for cloud-based distribution for inpatient and outpatient retinopathy of prematurity monitoring. Over 11 years, 367 premature infants in one NICU were prospectively monitored. The initial paper system missed 11% of potential examinations, the Windows server-based system missed 2%, and the current cloud-based system missed 0% of potential inpatient and outpatient examinations. Computer input of examinations took the same or less time than paper recording. A computer application with a deliberate NICU process improved the proportion of eligible neonates getting their scheduled eye examinations in a timely manner. Copyright 2012, SLACK Incorporated.

  14. A randomized study comparing short-time infusion of oxaliplatin in combination with capecitabine XELOX(30) and chronomodulated XELOX(30) as first-line therapy in patients with advanced colorectal cancer.

    PubMed

    Qvortrup, C; Jensen, B V; Fokstuen, T; Nielsen, S E; Keldsen, N; Glimelius, B; Bjerregaard, B; Mejer, J; Larsen, F O; Pfeiffer, P

    2010-01-01

    Chronotherapy is one of the several approaches to increase efficacy and reduce toxicity of chemotherapy. In a phase II study in the second-line in patients with metastatic colorectal cancer (mCRC), we found that chronomodulated XELOX (XELOX(30Chron)) was a well-tolerated regimen with potentially reduced toxicity. One hundred and forty-one patients with unresectable mCRC were enrolled in a randomized study comparing standard XELOX (XELOX(30)), arm A, and XELOX(30Chron), arm B-both with short-time infusion of oxaliplatin-with the primary aim of reducing overall toxicity. Overall toxicity grade 2-4 was 90% versus 85%, P = 0.47 and grade 3-4 was 31% versus 37%, P = 0.6 in arm A and B, respectively. We found no significant differences in median overall survival (17.6 versus 15.5 months; P = 0.068) and median progression-free survival (8.9 versus 8.8 months; P = 0.7). The incidence of grade 3 neuropathy was 16% in arm A and 19% in arm B (P = 0.7) after a cumulative dose of oxaliplatin of 1000 mg/m(2). XELOX(30Chron) does not reduce toxicity or improve efficacy. A 30-min infusion of oxaliplatin is safe and does not increase the severity of chronic neuropathy.

  15. Treatment of adult lymphoblastic leukaemia using cyclical chemotherapy with three combinations of four drugs (COAP, POMP, TRAP schedule).

    PubMed

    Proctor, S J; Finney, R; Walker, W; Thompson, R B

    1981-01-01

    Seventeen adult patients with previously untreated acute lymphoblastic leukaemia (ALL) were entered into a schedule of chemotherapy in which 3 combinations, each of 4 drugs, were administered in a predetermined cyclical rotation in combination with cranial irradiation and intrathecal injections of methotrexate. Of the 17 patients, 16 completed induction therapy and 15 (94%) entered remission. The only patient with T-ALL died before receiving any therapy. The median survival for all patients (17) was 22 months. Meningeal leukaemia did not occur during the haematological remission phase although 3 patients developed this complication following relapse. The authors conclude that the addition of cyclophosphamide and cytosine arabinoside to vincristine/prednisone provides excellent remission induction but the aggressive maintenance schedule employed has not led to significant long-term survival.

  16. Treatment of adult lymphoblastic leukaemia using cyclical chemotherapy with three combinations of four drugs (COAP, POMP, TRAP schedule).

    PubMed Central

    Proctor, S. J.; Finney, R.; Walker, W.; Thompson, R. B.

    1981-01-01

    Seventeen adult patients with previously untreated acute lymphoblastic leukaemia (ALL) were entered into a schedule of chemotherapy in which 3 combinations, each of 4 drugs, were administered in a predetermined cyclical rotation in combination with cranial irradiation and intrathecal injections of methotrexate. Of the 17 patients, 16 completed induction therapy and 15 (94%) entered remission. The only patient with T-ALL died before receiving any therapy. The median survival for all patients (17) was 22 months. Meningeal leukaemia did not occur during the haematological remission phase although 3 patients developed this complication following relapse. The authors conclude that the addition of cyclophosphamide and cytosine arabinoside to vincristine/prednisone provides excellent remission induction but the aggressive maintenance schedule employed has not led to significant long-term survival. PMID:6944694

  17. ASTER Scheduling Prioritization Function

    NASA Technical Reports Server (NTRS)

    Cohen, Ron

    1996-01-01

    ASTER schedules are generated by an automated scheduling system. This scheduler will generate psuedo-optimal schedules based on a priority scheme. This priority scheme is controlled by the Science Team.

  18. Experience with poorly myelosuppressive chemotherapy schedules for advanced myeloma. The Cooperative Group of Study and Treatment of Multiple Myeloma.

    PubMed Central

    Brugnatelli, S.; Riccardi, A.; Ucci, G.; Mora, O.; Barbarano, L.; Piva, N.; Piccinini, L.; Bergonzi, C.; De Paoli, A.; Di Stasi, M.; Rinaldi, E.; Trotti, G.; Petrini, M.; Ascari, E.

    1996-01-01

    In a multicentre study, 83 patients with advanced and previously uniformly treated multiple myeloma (MM) were randomised between cyclophosphamide (600 mg m-2) and epirubicin (70 mg m-2), administered every 3 weeks for three courses and both associated with prednisone and interferon-alpha2b. Both regimens were administered on an outpatient basis and had low haematological toxicity. Clinical results were similar. Overall response rate (43%) and median response and survival (5.9 and 14.1 months respectively) compare well with those obtained with more aggressive chemotherapy schedules. PMID:8611382

  19. A prospective cohort study to compare treatment results between 2 fractionation schedules of high-dose-rate intracavitary brachytherapy (HDR-ICBT) in patients with cervical cancer.

    PubMed

    Huang, Eng-Yen; Sun, Li-Min; Lin, Hao; Lan, Jen-Hong; Chanchien, Chan-Chao; Huang, Yu-Jie; Wang, Chang-Yu; Wang, Chong-Jong

    2013-01-01

    To compare the treatment results of 2 fractionation schedules for high-dose-rate intracavitary brachytherapy (HDR-ICBT) in patients with cervical cancer. From June 2001 through January 2008, 267 patients with stage IB-IVA cervical cancer were enrolled in the study. All patients underwent 4-field pelvic irradiation and HDR-ICBT. The median central and parametrial doses were 39.6 Gy and 45 Gy, respectively. Patient underwent either 6 Gy×4 (HDR-4) (n=144) or 4.5 Gy×6 (HDR-6) (n=123) to point A of ICBT using 192Ir isotope twice weekly. The rates of overall survival, locoregional failure, distant metastasis, proctitis, cystitis, and enterocolitis were compared between HDR-4 and HDR-6. There were no significant differences in the demographic data between HDR-4 and HDR-6 except for total treatment time. The 5-year proctitis rates were 23.0% and 21.5% in HDR-4 and HDR-6 (P=.399), respectively. The corresponding rates of grade 2-4 proctitis were 18.7% and 9.6% (P=.060). The corresponding rates of grades 3-4 proctitis were 5.2% and 1.3% (P=.231). Subgroup analysis revealed that HDR-4 significantly increased grade 2-4 proctitis in patients aged≥62 years old (P=.012) but not in patients aged<62 years (P=.976). The rates of overall survival, locoregional failure, distant metastasis, cystitis, and enterocolitis were not significantly different between HDR-4 and HDR-6 schedules. The small fraction size of HDR-ICBT is associated with grade 2 proctitis without compromise of prognosis in elderly patients. This schedule is suggested for patients who tolerate an additional 2 applications of HDR-ICBT. Copyright © 2013 Elsevier Inc. All rights reserved.

  20. A Prospective Cohort Study to Compare Treatment Results Between 2 Fractionation Schedules of High-Dose-Rate Intracavitary Brachytherapy (HDR-ICBT) in Patients With Cervical Cancer

    SciTech Connect

    Huang, Eng-Yen; Sun, Li-Min; Lin, Hao; Lan, Jen-Hong; Chanchien, Chan-Chao; Huang, Yu-Jie; Wang, Chang-Yu; Wang, Chong-Jong

    2013-01-01

    Purpose: To compare the treatment results of 2 fractionation schedules for high-dose-rate intracavitary brachytherapy (HDR-ICBT) in patients with cervical cancer. Methods and Materials: From June 2001 through January 2008, 267 patients with stage IB-IVA cervical cancer were enrolled in the study. All patients underwent 4-field pelvic irradiation and HDR-ICBT. The median central and parametrial doses were 39.6 Gy and 45 Gy, respectively. Patient underwent either 6 Gy Multiplication-Sign 4 (HDR-4) (n=144) or 4.5 Gy Multiplication-Sign 6 (HDR-6) (n=123) to point A of ICBT using {sup 192}Ir isotope twice weekly. The rates of overall survival, locoregional failure, distant metastasis, proctitis, cystitis, and enterocolitis were compared between HDR-4 and HDR-6. Results: There were no significant differences in the demographic data between HDR-4 and HDR-6 except for total treatment time. The 5-year proctitis rates were 23.0% and 21.5% in HDR-4 and HDR-6 (P=.399), respectively. The corresponding rates of grade 2-4 proctitis were 18.7% and 9.6% (P=.060). The corresponding rates of grades 3-4 proctitis were 5.2% and 1.3% (P=.231). Subgroup analysis revealed that HDR-4 significantly increased grade 2-4 proctitis in patients aged {>=}62 years old (P=.012) but not in patients aged <62 years (P=.976). The rates of overall survival, locoregional failure, distant metastasis, cystitis, and enterocolitis were not significantly different between HDR-4 and HDR-6 schedules. Conclusion: The small fraction size of HDR-ICBT is associated with grade 2 proctitis without compromise of prognosis in elderly patients. This schedule is suggested for patients who tolerate an additional 2 applications of HDR-ICBT.

  1. Comparison of lime powder and caustic soda as a pre-treatment for ammonia-nitrogen removal from a scheduled waste leachate

    NASA Astrophysics Data System (ADS)

    Nurul Hanira M., L.; Hasfalina C., M.; Sani, A.; Rashid, M.

    2015-05-01

    Studies on leachate taken from scheduled waste landfill are limited. This might be due to the complex characteristics of the leachate from scheduled waste landfill compared to other types of landfills. Leachate is known as a strong wastewater in terms of its organic matter and ammonia content. In this study, a pre-treatment on the removal of ammonia-nitrogen (NH3-N) by coagulation on a leachate sample taken from a Scheduled Waste Landfill (SWL) is reported. The coagulation was performed using lime (Ca (OH)2), and caustic soda (NaOH) with varying pH and amount of coagulant. A different dosage of Ca (OH)2, and NaOH was applied and the removal efficiency using both coagulants were investigated to find the most optimum dosage for NH3-N removal. Results showed that the percentage of NH3-N removal was relatively the same for both Ca (OH)2 and NaOH which was up to 45% and 48%, respectively. The optimum pH and dosage of coagulant for the removal process using Ca (OH)2 was pH=12.40±0.02 and 6gL-1, respectively while with NaOH was pH=12.83±0.02 and 8 gL-1, respectively. A small difference in the removal of NH3-N with a less dosage of coagulant used in the study suggests that lime (Ca(OH)2), is a better choice for the pre-treatment process.

  2. Combined radiation and hyperthermia: comparison of two treatment schedules based on data from a registry established by the Radiation Therapy Oncology Group (RTOG).

    PubMed

    Luk, K H; Francis, M E; Perez, C A; Johnson, R J

    1984-06-01

    A registry established by the Radiation Therapy Oncology Group provides data for assessing the impact of clinical heating in a set of non-randomized patients treated with hyperthermia in participating member institutions from 1/77 to 6/81. This analysis focuses on tumor response when localized hyperthermia is produced by microwave and applied pursuant to two distinctly different treatment schedules. Hyperthermia treatments were biweekly and combined with daily radiation treatments in one patient group, and combined with biweekly radiation treatment in another. Sample X consists of 65 patients who received a course of therapy using combined hyperthermia and radiation in consecutive treatment sessions each separated by at least 48 hours, but no more than 96 hours. Sample Y consists of 34 patients who received further radiation after the start of a course of combined therapy--either between or at the end of a series of combined treatment sessions. The average length of heat treatment was 72 minutes for Sample X and 32 minutes for Sample Y patients. None of the patients received concurrent chemotherapy; all received between 3 and 13 hyperthermia treatments; all had superficial, measurable tumors. On the average, Sample X patients received 704 total minutes of heat compared to Sample Y patients who received 233 total minutes of heat. Total tumor radiation doses ranged from 17.0 Gy to 44.0 Gy among Sample X patients with 92.3% receiving radiation at either 3 Gy or 4 Gy per fraction. In Sample Y the range for total tumor dose was 16.0 Gy to 70.2 Gy with 73.4% of the patients receiving radiation at 2.5 Gy or less per fraction. Generally, the two treatment schedules achieved similar levels of tumor response. Among treated tumors in Sample X and Sample Y, complete regression rates were 52.4 and 61.8%, respectively, and partial regression rates were 16.9 and 14.7%. Adenocarcinoma and squamous cell carcinoma in both samples responded well to these combined treatments. Only in

  3. Accelerated immunotherapy schedules and premedication.

    PubMed

    Calabria, Christopher W; Cox, Linda

    2011-05-01

    Subcutaneous immunotherapy is divided into a buildup and a maintenance phase. Accelerated immunotherapy has the advantage of a reduced number of office visits. Rush and cluster immunotherapy schedules are the most common accelerated schedules used in the United States. A cluster immunotherapy schedule involves the patient receiving several allergen injections sequentially in a single day of treatment on nonconsecutive days. The maintenance dose is reached in 4 to 8 weeks. In rush immunotherapy protocols, higher doses are administered at intervals of 15 to 60 minutes in a period of 1 to 3 days until the maintenance dose is achieved. Copyright © 2011 Elsevier Inc. All rights reserved.

  4. Treatment of myelodysplastic syndrome with 2 schedules and doses of oral topotecan: a randomized phase 2 trial by the Cancer and Leukemia Group B (CALGB 19803).

    PubMed

    Grinblatt, David L; Yu, Daohai; Hars, Vera; Vardiman, James W; Powell, Bayard L; Nattam, Sreenivasa; Silverman, Lewis R; de Castro, Carlos; Stone, Richard M; Bloomfield, Clara D; Larson, Richard A

    2009-01-01

    The Cancer and Leukemia Group B evaluated oral topotecan administered at 2 schedules and doses for myelodysplastic syndrome (MDS). Patients with previously untreated primary or therapy-related MDS were eligible. Patients with refractory anemia (RA), RA with ringed sideroblasts, or refractory cytopenia with multilineage dysplasia (RCMD) were eligible only if they were dependent on erythrocyte transfusion, had a platelet count<50,000/microL, or had an absolute neutrophil count<1000/microL with a recent infection that required antibiotics. Patients were randomized to receive oral topotecan either at a dose of 1.2 mg/m2 twice daily for 5 days (Arm A) or once daily for 10 days (Arm B) repeated every 21 days for at least 2 cycles. Responding patients continued until they developed disease progression or unacceptable toxicity or until they had received 2 cycles beyond a complete response. Ninety patients received treatment, including 46 patients on Arm A and 44 patients on Arm B. Partial responses with improvement in all 3 cell lines occurred in 6 patients (7%), and hematologic improvement (in 1 or 2 cell lines) was observed in 21 patients (23%), for an overall response rate of 30%. Response duration was longer on Arm A (23 months vs 14 months; P=.02). Seven of 14 patients with chronic myelomonocytic leukemia responded. There were 8 treatment-related deaths from infection (6 deaths) and bleeding (2 deaths). Diarrhea was the most frequent nonhematologic toxicity (grade 3, 11%; grade 4, 2%; grading determined according to the National Cancer Institute Comman Toxicity Criteria v.2.0). Oral topotecan in the dose and schedules evaluated in this trial demonstrated only a modest response rate with a troublesome toxicity profile in the treatment of MDS. Copyright (c) 2008 American Cancer Society.

  5. Rats made cirrhotic by chronic CCl4 treatment still exhibit anticipatory activity to a restricted feeding schedule.

    PubMed

    Escobar, Carolina; Mendoza, Jorge Y; Salazar-Juárez, Alberto; Avila, José; Hernández-Muñoz, Rolando; Díaz-Muñoz, Mauricio; Aguilar-Roblero, Raúl

    2002-11-01

    Food entrainment of clock genes in the liver suggests that this organ may underlie a food entrained oscillator (FEO), which manifests under restricted feeding schedule (RFS). In order to test the importance of a functional liver for the expression of FEO, chronic CCl4-treated cirrhotic rats and oil-treated controls were entrained to RFS and drinking behavior was continuously monitored. After 20 d of free-running conditions, food access was restricted to 2 h, followed by a refeeding-fasting protocol to test persistence of anticipatory drinking. Present data show no differences between groups for the onset and intensity of anticipation during RFS. After RFS, however, cirrhotic rats exhibited a significantly longer free-running period and a delay and lower intensity of the persistence of activity under fasting conditions. Histology confirmed injury of the liver chronically treated with CCl4. Present data indicate that a dysfunctional liver due to chronic CCl4 does not prevent animals from exhibiting anticipatory activity but may promote metabolic derangement of the clock mechanisms of the suprachiasmatic nucleus and the FEO.

  6. Radiochemotherapy in Anal Cancer: cCR, clinical outcomes and quality of life using two different treatment schedules

    PubMed Central

    Di Santo, Sara; Trignani, Marianna; Neri, Matteo; Milano, Angelo; Innocenti, Paolo; Taraborrelli, Maria; Augurio, Antonietta; Vinciguerra, Annamaria; Di Tommaso, Monica; Ursini, Lucia Anna; Di Pilla, Angelo; Di Nicola, Marta; Genovesi, Domenico

    2014-01-01

    Aim Main endpoint was a response rate to therapy; secondary endpoints were disease-free survival, overall survival, acute and late toxicities, specially in terms of anorectal and urinary continence. Background Radiochemotherapy for anal cancer achieves a good clinical response, locoregional control, anal function preservation. However, oncologic outcomes can differ using radiotherapy plus fluorouracil and mytomicin vs. cisplatin and fluorouracil. Methods Between 2000 and 2012, 27 anal cancer patients receiving radiotherapy combined with two different radiochemotherapy schedules, fluorouracil and mytomicin (group A) and cisplatin plus fluorouracil (group B). The Kaplan–Meier method was also used to estimate local control, overall survival and disease free survival. Statistical significance between curves was evaluated using the Log-rank test. Results Complete pathological response was found in 85.2% of patients, with higher rates of response in the group A (100% vs. 63.6%, p = 0.039). No significantly difference was found between the two groups for the other endpoints. Low rates of both acute and late toxicities were recorded. Conclusion Radiotherapy plus fluorouracil and mytomicin provide a better complete pathological response than radiotherapy plus cisplatin and fluorouracil and a greater rate of anal sphincter function preservation. Globally, radiochemotherapy of the anal cancer provides excellent clinical outcomes with a good profile of acute and late toxicity, without difference between the two groups studied. PMID:25859401

  7. DSIF station schedules

    NASA Technical Reports Server (NTRS)

    Flarity, L. D.; Hanson, R. J.; Thom, E. H.

    1971-01-01

    System manages Deep Space Instrumentation Facilities /DSIF/ equipment construction and modification planning. Versatile program applies to such tasks as employee time and task schedules, pay schedules, operations schedules, and plant and equipment procurement, construction, modification or service.

  8. The Hybrid Schedule: Scheduling to the Curriculum.

    ERIC Educational Resources Information Center

    Boarman, Gerald L.; Kirkpatrick, Barbara S.

    1995-01-01

    A series of experiments with single and double mod scheduling at a large suburban Maryland high school has led to a highly flexible schedule that meets teachers' and students' needs. This schedule allows courses to be offered in the most suitable format, creates more time for students and teachers, streamlines hallway traffic, and fosters a team…

  9. Iterative refinement scheduling

    NASA Technical Reports Server (NTRS)

    Biefeld, Eric

    1992-01-01

    We present a heuristics-based approach to deep space mission scheduling which is modeled on the approach used by expert human schedulers in producing schedules for planetary encounters. New chronological evaluation techniques are used to focus the search by using information gained during the scheduling process to locate, classify, and resolve regions of conflict. Our approach is based on the assumption that during the construction of a schedule there exist several disjunct temporal regions where the demand for one resource type or a single temporal constraint dominates (bottleneck regions). If the scheduler can identify these regions and classify them based on their dominant constraint, then the scheduler can select the scheduling heuristic.

  10. Scheduler's assistant: a tool for intelligent scheduling

    NASA Astrophysics Data System (ADS)

    Griffin, Neal L.

    1991-03-01

    The objective of this project was to use expert system technology to aid in the scheduling activities performed at the White Sands Missile Range (WSMR). The WSMR range scheduling problem presents a complex interactive environment. A human factors approach was undertaken, in that, the goal was to implement a system which mimics current WSMR scheduling procedures. The results of this project have produced a prototypic scheduling tool, called Scheduler's Assistant (SA), to aid WSMR range schedulers to generate a daily schedule. The system provides resource conflict detection and resolution advice through a series of cooperating expert systems. Immediate advantages of the system are increased safety, insurance of proper schedule execution and improved speed for turnaround time of sudden schedule changes. Additional benefits of SA include: expandability as future operations grow, allows for rapid redeployment for changing resources, promotes efficient management of WSMR resources, provides a formal representation of knowledge such that years of range personnel experience is preserved and enables the flexibility of a scheduling aid as opposed to a rigid methodology. Prior development efforts by Perceptics have produced a sophisticated expert system development tool, called Knowledge Shaper, which was used to implement all of the expert systems. The development of SA included a library of routines (the SA toolbox) to permit the manipulation of internal data tables and define a data transfer protocol to and from the SA environment. The combination of Knowledge Shaper and the SA toolbox provide a powerful set of design tools for the development of future scheduling applications.

  11. Effects of acute and chronic aripiprazole treatment on choice between cocaine self-administration and food under a concurrent schedule of reinforcement in rats.

    PubMed

    Thomsen, Morgane; Fink-Jensen, Anders; Woldbye, David P D; Wörtwein, Gitta; Sager, Thomas N; Holm, Rene; Pepe, Lauren M; Caine, S Barak

    2008-11-01

    Dopamine D2-like partial agonists such as aripiprazole have received some attention as potential pharmacotherapies for the treatment of psychostimulant addiction. However, the preclinical evaluations so far have focused on acute effects of aripiprazole. We tested the hypothesis that aripiprazole, both as acute and as chronic treatment, would preferentially decrease cocaine self-administration while sparing behavior maintained by a natural reinforcer, resulting in a shift in the allocation of behavior from cocaine-taking towards the alternative reinforcer. Rats were trained to self-administer intravenous cocaine in a concurrent choice procedure, with a palatable food as the competing reinforcer, under a fixed ratio (FR) 1 FR 5 chain schedule. Aripiprazole was then administered as continuous infusion by osmotic minipumps for 5 days, during which performance in the choice procedure was assessed daily. An intermediate dose of aripiprazole decreased cocaine self-administration and shifted the cocaine choice curve to the right as an acute treatment. However, as a chronic treatment, aripiprazole failed to decrease cocaine self-administration or cocaine choice, despite a dose-dependent decrease in overall response rates and food-maintained behavior. Our results confirm and extend earlier findings and indicate that acute administration of aripiprazole can decrease cocaine self-administration. However, based on the present data, chronic treatment with aripiprazole does not show much promise as a potential pharmacotherapy for cocaine addiction. Both acute and chronic treatment data are in agreement with published clinical findings, suggesting that the concurrent choice procedure in rats has predictive validity of efficacy in humans.

  12. Protocols for distributive scheduling

    NASA Technical Reports Server (NTRS)

    Richards, Stephen F.; Fox, Barry

    1993-01-01

    The increasing complexity of space operations and the inclusion of interorganizational and international groups in the planning and control of space missions lead to requirements for greater communication, coordination, and cooperation among mission schedulers. These schedulers must jointly allocate scarce shared resources among the various operational and mission oriented activities while adhering to all constraints. This scheduling environment is complicated by such factors as the presence of varying perspectives and conflicting objectives among the schedulers, the need for different schedulers to work in parallel, and limited communication among schedulers. Smooth interaction among schedulers requires the use of protocols that govern such issues as resource sharing, authority to update the schedule, and communication of updates. This paper addresses the development and characteristics of such protocols and their use in a distributed scheduling environment that incorporates computer-aided scheduling tools. An example problem is drawn from the domain of space shuttle mission planning.

  13. Aspects of job scheduling

    NASA Technical Reports Server (NTRS)

    Phillips, K.

    1976-01-01

    A mathematical model for job scheduling in a specified context is presented. The model uses both linear programming and combinatorial methods. While designed with a view toward optimization of scheduling of facility and plant operations at the Deep Space Communications Complex, the context is sufficiently general to be widely applicable. The general scheduling problem including options for scheduling objectives is discussed and fundamental parameters identified. Mathematical algorithms for partitioning problems germane to scheduling are presented.

  14. Aspects of job scheduling

    NASA Technical Reports Server (NTRS)

    Phillips, K.

    1976-01-01

    A mathematical model for job scheduling in a specified context is presented. The model uses both linear programming and combinatorial methods. While designed with a view toward optimization of scheduling of facility and plant operations at the Deep Space Communications Complex, the context is sufficiently general to be widely applicable. The general scheduling problem including options for scheduling objectives is discussed and fundamental parameters identified. Mathematical algorithms for partitioning problems germane to scheduling are presented.

  15. Assessment of the effects of dalteparin on coagulation variables and determination of a treatment schedule for use in cats.

    PubMed

    Schönig, Jette C; Mischke, Reinhard H

    2016-07-01

    OBJECTIVE To determine a treatment protocol for SC administration of dalteparin to cats on the basis of currently available detailed pharmacokinetic data and to assess the effect of SC administration of dalteparin to cats on coagulation variables such as activated partial thromboplastin time (aPTT), thrombin time, and results for thromboelastometry, compared with effects on anti-activated coagulation factor X (anti-Xa) activity. ANIMALS 6 healthy domestic shorthair cats. PROCEDURES Cats received 14 injections of dalteparin (75 anti-Xa U/kg, SC) at 6-hour intervals. Blood samples were collected before and 2 hours after the first and second injections on days 1, 2, and 4. Anti-Xa activity was measured by use of a chromogenic substrate assay, aPTT and thrombin time were measured by use of an automated coagulometer, and viscoelastic measurements were obtained with thromboelastrometry. RESULTS 2 hours after the second injection, the target peak anti-Xa activity range of 0.5 to 1.0 U/mL was achieved in all cats, whereas median trough values remained below this range. Peak anti-Xa activity had only minimal effects on coagulation variables; the maximum median ratio for aPTT (in relationship to the value before the first dalteparin injection) was 1.23. CONCLUSIONS AND CLINICAL RELEVANCE Results of this study indicated that this treatment protocol resulted in reproducible anti-Xa activity in cats that was mostly within the targeted peak range of anti-Xa activity recommended for humans. Treatment in accordance with this protocol may not require routine coagulation monitoring of cats, but this must be confirmed in feline patients.

  16. Connections between nutritional status and proton pump inhibitor therapy in patients scheduled for cardiovascular rehabilitation after treatment for ischaemic and valvular heart disease.

    PubMed

    Boban, Marko; Persic, Viktor; Petricevic, Mate; Biocina, Bojan; Sipic, Tomislav; Pehar-Pejcnovic, Vesna; Balen, Sanja; Zulj, Marinko; Vcev, Aleksandar

    Multiple and yet uncertain connections exist between cardiovascular diseases and the nutritional status of patients, particularly in relation to cardiovascular treatments. Proton pump inhibitors (PPI) are among the most commonly used group of drugs. To analyse utilisation of PPI in association with nutritional risk of patients scheduled for rehabilitation after treatment for ischaemic and valvular heart disease. Retrospective analyses on a consecutive sample of patients, which included drug utilisation of PPI and nutritional risk screening, using a standardised NRS-2002 tool. The patients (n = 536) were divided into groups based on previous cardiovascular treatments and use of PPI. Nearly half of the patients (244, 46.1%) had PPI in their chronic therapy despite the clinically negligible prevalence of conditions that are their fundamental indications. The odds for using PPI in patients with increased nutritional risk, estimated by logistic regression, were 3.34 (95% confidence intervals [CI] 2.26-4.94), p < 0.001. Receiver operating curve analyses also revealed significant differences of PPI utilisation in connection with NRS-2002 > 3: positive likelihood-ratio (LR) 2.35 (95% CI 2.10-2.60); negative LR 0.46 (95% CI 0.4-0.6); area under the curve (AUC) 0.720; p < 0.001; as well as the percentage weigh loss history > 6.36% (positive LR 2.22 [95% CI 2.00-2.50]; negative LR 0.41 [95% CI 0.30-0.50]; AUC 0.707; p < 0.001). Utilisation of PPI was found to be of relatively high prevalence and significantly associated with parameters of nutritional risk screening. Furthermore, it was in correlation with the age of patients and the existence of chronic kidney disease, which are well-established predispositions for poor nutritional status. Nutritional risk seems to be additionally negatively challenged by utilisation of PPI due to gastric malabsorption and anaemia.

  17. Dedicated heterogeneous node scheduling including backfill scheduling

    DOEpatents

    Wood, Robert R.; Eckert, Philip D.; Hommes, Gregg

    2006-07-25

    A method and system for job backfill scheduling dedicated heterogeneous nodes in a multi-node computing environment. Heterogeneous nodes are grouped into homogeneous node sub-pools. For each sub-pool, a free node schedule (FNS) is created so that the number of to chart the free nodes over time. For each prioritized job, using the FNS of sub-pools having nodes useable by a particular job, to determine the earliest time range (ETR) capable of running the job. Once determined for a particular job, scheduling the job to run in that ETR. If the ETR determined for a lower priority job (LPJ) has a start time earlier than a higher priority job (HPJ), then the LPJ is scheduled in that ETR if it would not disturb the anticipated start times of any HPJ previously scheduled for a future time. Thus, efficient utilization and throughput of such computing environments may be increased by utilizing resources otherwise remaining idle.

  18. Development of phytosanitary cold treatments for oranges infested with Bactrocera invadens and B. zonata (Diptera: Tephritidae) by comparison...existing cold treatment schedules for Ceratitis capitata (Diptera: Tephritidae)

    USDA-ARS?s Scientific Manuscript database

    Phytosanitary cold treatments are attempted for Bactrocera invadens Drew, Tsuruta, and White and Bactrocera zonata (Saunders) by comparison with Ceratitis capitata (Wiedemann). Oranges were infested by puncturing holes in the peel and allowing tephritids to oviposit in the holes. The treatments were...

  19. Modelling the Protective Efficacy of Alternative Delivery Schedules for Intermittent Preventive Treatment of Malaria in Infants and Children

    PubMed Central

    Cairns, Matthew; Ghani, Azra; Okell, Lucy; Gosling, Roly; Carneiro, Ilona; Anto, Francis; Asoala, Victor; Owusu-Agyei, Seth; Greenwood, Brian; Chandramohan, Daniel; Milligan, Paul

    2011-01-01

    Background Intermittent preventive treatment in infants (IPTi) with sulfadoxine-pyrimethamine (SP) is recommended by WHO where malaria incidence in infancy is high and SP resistance is low. The current delivery strategy is via routine Expanded Program on Immunisation contacts during infancy (EPI-IPTi). However, improvements to this approach may be possible where malaria transmission is seasonal, or where the malaria burden lies mainly outside infancy. Methods and Findings A mathematical model was developed to estimate the protective efficacy (PE) of IPT against clinical malaria in children aged 2-24 months, using entomological and epidemiological data from an EPI-IPTi trial in Navrongo, Ghana to parameterise the model. The protection achieved by seasonally-targeted IPT in infants (sIPTi), seasonal IPT in children (sIPTc), and by case-management with long-acting artemisinin combination therapies (LA-ACTs) was predicted for Navrongo and for sites with different transmission intensity and seasonality. In Navrongo, the predicted PE of sIPTi was 26% by 24 months of age, compared to 16% with EPI-IPTi. sIPTc given to all children under 2 years would provide PE of 52% by 24 months of age. Seasonally-targeted IPT retained its advantages in a range of transmission patterns. Under certain circumstances, LA-ACTs for case-management may provide similar protection to EPI-IPTi. However, EPI-IPTi or sIPT combined with LA-ACTs would be substantially more protective than either strategy used alone. Conclusion Delivery of IPT to infants via the EPI is sub-optimal because individuals are not protected by IPT at the time of highest malaria risk, and because older children are not protected. Alternative delivery strategies to the EPI are needed where transmission varies seasonally or the malaria burden extends beyond infancy. Long-acting ACTs may also make important reductions in malaria incidence. However, delivery systems must be developed to ensure that both forms of chemoprevention

  20. Interference Cognizant Network Scheduling

    NASA Technical Reports Server (NTRS)

    Varadarajan, Srivatsan (Inventor); Hall, Brendan (Inventor); Smithgall, William Todd (Inventor); Bonk, Ted (Inventor); DeLay, Benjamin F. (Inventor)

    2017-01-01

    Systems and methods for interference cognizant network scheduling are provided. In certain embodiments, a method of scheduling communications in a network comprises identifying a bin of a global timeline for scheduling an unscheduled virtual link, wherein a bin is a segment of the timeline; identifying a pre-scheduled virtual link in the bin; and determining if the pre-scheduled and unscheduled virtual links share a port. In certain embodiments, if the unscheduled and pre-scheduled virtual links don't share a port, scheduling transmission of the unscheduled virtual link to overlap with the scheduled transmission of the pre-scheduled virtual link; and if the unscheduled and pre-scheduled virtual links share a port: determining a start time delay for the unscheduled virtual link based on the port; and scheduling transmission of the unscheduled virtual link in the bin based on the start time delay to overlap part of the scheduled transmission of the pre-scheduled virtual link.

  1. Performance improvement in behavioral health care: collateral effects of planned treatment integrity observations as an applied example of schedule-induced responding.

    PubMed

    Reed, Derek D; Fienup, Daniel M; Luiselli, James K; Pace, Gary M

    2010-09-01

    With rising interest in the role of treatment integrity on student outcomes, research has primarily focused on isolating the techniques and procedures necessary to improve staff's acquisition and maintenance of adequate levels of integrity. Despite increasing numbers of publications on this topic, there has been little discussion of the variables surrounding the collection of integrity data. Using an archived database of logged integrity observations at a residential school for children with brain injury, the authors sought to examine the degree to which integrity data collection conformed to best practices of behavioral assessment with respect to temporal sequencing. Moreover, due to the agency's goal of collecting integrity on each student per month, the authors sought to examine whether the sequencing of integrity observations scalloped similarly to responding on conjunctive fixed-interval-fixed-ratio schedules. Results indicated that a majority of the staff exhibited some form of scalloping in their collection of integrity data. This article discusses possible sources of stimulus control and the potential for reactivity on the part of the teachers being observed when integrity observations are conducted in scalloped patterns. The authors conclude with a discussion on possible procedures to support the distributed collection of integrity data in applied setting.

  2. Distributed scheduling with COMPASS

    NASA Technical Reports Server (NTRS)

    Rufat-Latre, Jorge; Culbert, Chris

    1991-01-01

    COMPASS (COMPuter Aided Scheduling System) is a sophisticated, interactive scheduling tool used within NASA. Like most existing tools, however, COMPASS is a single-user application. There is a large class of scheduling problems which may be better solved by allowing several people at various locations to build separate schedules with shared resources. DISCORS (DIStributed COmputer Resource Scheduling) is a set of services which support a distributed version of COMPASS. This architecture naturally accommodates the integration of user-defined resource models without modifying COMPASS. DISCORS services include the ability to establish and manage communications, to code messages in efficient formats, to provide fault detection and recovery, and to configure schedulers across a network. In its present form, DISCORS effectively supports distributed COMPASS, but fails to run fast and to guarantee efficient schedules. Further enhancements may allow several users to simultaneously and interactively work together to create complex schedules while COMPASS detects and coordinates the resolution of conflicting requests.

  3. Class Schedules Need Class.

    ERIC Educational Resources Information Center

    Monfette, Ronald J.

    1986-01-01

    Argues that college publications, including class schedules, must be accurate, timely, and easy to read and follow. Describes Schoolcraft College's unified format approach to publications marketing. Offers suggestions on the design, format, and distribution of class schedules. (DMM)

  4. Immunization Schedules for Adults

    MedlinePlus

    ... ACIP Vaccination Recommendations Why Immunize? Vaccines: The Basics Immunization Schedules for Adults in Easy-to-read Formats ... previous immunizations. View or Print a Schedule Recommended Immunizations for Adults (19 Years and Older) by Age ...

  5. Instant Childhood Immunization Schedule

    MedlinePlus

    ... Recommendations Why Immunize? Vaccines: The Basics Instant Childhood Immunization Schedule Recommend on Facebook Tweet Share Compartir Get ... date. See Disclaimer for additional details. Based on Immunization Schedule for Children 0 through 6 Years of ...

  6. School Construction Scheduling.

    ERIC Educational Resources Information Center

    Delaney, J. B.

    1983-01-01

    Explains that favorable market and working conditions influence the scheduling of school construction projects. Facility planners, architects, and contractors are advised to develop a realistic time schedule for the entire project. (MLF)

  7. Schedule Risk Assessment

    NASA Technical Reports Server (NTRS)

    Smith, Greg

    2003-01-01

    Schedule Risk Assessment needs to determine the probability of finishing on or before a given point in time. Task in a schedule should reflect the "most likely" duration for each task. IN reality, each task is different and has a varying degree of probability of finishing within or after the duration specified. Schedule risk assessment attempt to quantify these probabilities by assigning values to each task. Bridges the gap between CPM scheduling and the project's need to know the likelihood of "when".

  8. Reinforcement learning in scheduling

    NASA Technical Reports Server (NTRS)

    Dietterich, Tom G.; Ok, Dokyeong; Zhang, Wei; Tadepalli, Prasad

    1994-01-01

    The goal of this research is to apply reinforcement learning methods to real-world problems like scheduling. In this preliminary paper, we show that learning to solve scheduling problems such as the Space Shuttle Payload Processing and the Automatic Guided Vehicle (AGV) scheduling can be usefully studied in the reinforcement learning framework. We discuss some of the special challenges posed by the scheduling domain to these methods and propose some possible solutions we plan to implement.

  9. Clustered schedules in allergen-specific immunotherapy.

    PubMed

    Parmiani, S; Fernández Távora, L; Moreno, C; Guardia, P; Rico, P

    2002-01-01

    Injective immunotherapy is traditionally performed with a build-up phase lasting 3 to 4 months. The costs, decreasing compliance from both patients and clinicians and inconveniences due to this schedule may be overcome using different schedules. A revision of the published papers with clustered schedules has been made. Attention has been focussed on tolerance and its relationships with relevant parameters such as kind of extract (aqueous or depot), allergens and their pharmaceutical presentation, schedule followed, use or not of a premedication, clinical manifestations of patients before treatment. For a better revision, papers dealing with clustered schedules have been divided into two groups. The first group includes 20 papers not designed to study the clustered schedule but using it to study other parameters affected by specific immunotherapy. The second group includes 9 papers specifically or mainly designed to study the clustered schedule. A huge difference in the rate of side effects could be assessed among different papers, even in studies run with similar allergens from the same producer and with a similar schedule. Summarizing the results of the revision, the following conditions seem to lead to the optimal tolerance of the clustered schedule: use of a premedication; use of a depot preparation; use of no more than 4 administrations per cluster; administration of 1-2 clusters per week and of 4 to 6 clusters in total. These results seem promising but further efforts are required to better define the optimal clustered schedule.

  10. 45 CFR 96.137 - Payment schedule.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 1 2013-10-01 2013-10-01 false Payment schedule. 96.137 Section 96.137 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION BLOCK GRANTS Substance Abuse Prevention and Treatment Block Grant § 96.137 Payment schedule. (a) The Block Grant money that may be...

  11. 45 CFR 96.137 - Payment schedule.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Payment schedule. 96.137 Section 96.137 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION BLOCK GRANTS Substance Abuse Prevention and Treatment Block Grant § 96.137 Payment schedule. (a) The Block Grant money that may be...

  12. 45 CFR 96.137 - Payment schedule.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 1 2014-10-01 2014-10-01 false Payment schedule. 96.137 Section 96.137 Public Welfare Department of Health and Human Services GENERAL ADMINISTRATION BLOCK GRANTS Substance Abuse Prevention and Treatment Block Grant § 96.137 Payment schedule. (a) The Block Grant money that may be...

  13. 45 CFR 96.137 - Payment schedule.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 1 2012-10-01 2012-10-01 false Payment schedule. 96.137 Section 96.137 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION BLOCK GRANTS Substance Abuse Prevention and Treatment Block Grant § 96.137 Payment schedule. (a) The Block Grant money that may be...

  14. 45 CFR 96.137 - Payment schedule.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 1 2011-10-01 2011-10-01 false Payment schedule. 96.137 Section 96.137 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION BLOCK GRANTS Substance Abuse Prevention and Treatment Block Grant § 96.137 Payment schedule. (a) The Block Grant money that may be...

  15. Web Publishing Schedule

    EPA Pesticide Factsheets

    Section 207(f)(2) of the E-Gov Act requires federal agencies to develop an inventory and establish a schedule of information to be published on their Web sites, make those schedules available for public comment. To post the schedules on the web site.

  16. An Evaluation of the "Treatment Integrity Planning Protocol" and Two Schedules of Treatment Integrity Self-Report: Impact on Implementation and Report Accuracy

    ERIC Educational Resources Information Center

    Hagermoser Sanetti, Lisa M.; Kratochwill, Thomas R.

    2011-01-01

    The evidence-based practice movement has focused on identifying, disseminating, and promoting the adoption of evidence-based interventions. Despite advances in this movement, numerous barriers, such as the lack of treatment integrity assessment methods, remain as challenges in implementation. Accurate teacher self-report could be an efficient…

  17. DSN Scheduling Engine

    NASA Technical Reports Server (NTRS)

    Clement, Bradley; Johnston, Mark; Wax, Allan; Chouinard, Caroline

    2008-01-01

    The DSN (Deep Space Network) Scheduling Engine targets all space missions that use DSN services. It allows clients to issue scheduling, conflict identification, conflict resolution, and status requests in XML over a Java Message Service interface. The scheduling requests may include new requirements that represent a set of tracks to be scheduled under some constraints. This program uses a heuristic local search to schedule a variety of schedule requirements, and is being infused into the Service Scheduling Assembly, a mixed-initiative scheduling application. The engine resolves conflicting schedules of resource allocation according to a range of existing and possible requirement specifications, including optional antennas; start of track and track duration ranges; periodic tracks; locks on track start, duration, and allocated antenna; MSPA (multiple spacecraft per aperture); arraying/VLBI (very long baseline interferometry)/delta DOR (differential one-way ranging); continuous tracks; segmented tracks; gap-to-track ratio; and override or block-out of requirements. The scheduling models now include conflict identification for SOA(start of activity), BOT (beginning of track), RFI (radio frequency interference), and equipment constraints. This software will search through all possible allocations while providing a best-effort solution at any time. The engine reschedules to accommodate individual emergency tracks in 0.2 second, and emergency antenna downtime in 0.2 second. The software handles doubling of one mission's track requests over one week (to 42 total) in 2.7 seconds. Further tests will be performed in the context of actual schedules.

  18. NASA scheduling technologies

    NASA Technical Reports Server (NTRS)

    Adair, Jerry R.

    1994-01-01

    This paper is a consolidated report on ten major planning and scheduling systems that have been developed by the National Aeronautics and Space Administration (NASA). A description of each system, its components, and how it could be potentially used in private industry is provided in this paper. The planning and scheduling technology represented by the systems ranges from activity based scheduling employing artificial intelligence (AI) techniques to constraint based, iterative repair scheduling. The space related application domains in which the systems have been deployed vary from Space Shuttle monitoring during launch countdown to long term Hubble Space Telescope (HST) scheduling. This paper also describes any correlation that may exist between the work done on different planning and scheduling systems. Finally, this paper documents the lessons learned from the work and research performed in planning and scheduling technology and describes the areas where future work will be conducted.

  19. Mature results of a randomized trial comparing two fractionation schedules of high dose rate endoluminal brachytherapy for the treatment of endobronchial tumors.

    PubMed

    Niemoeller, Olivier M; Pöllinger, Barbara; Niyazi, Maximilian; Corradini, Stefanie; Manapov, Farkhad; Belka, Claus; Huber, Rudolf M

    2013-01-07

    To determine the efficacy of high dose rate endobronchial brachytherapy (HDR-BT) for the treatment of centrally located lung tumors, two different fractionation schedules were compared regarding local tumor response, side effects and survival. Mature retrospective results with longer follow-up and more patients were analyzed. Initial results were published by Huber et al. in 1995. 142 patients with advanced, centrally located malignant tumors with preferential endoluminal growth were randomized to receive 4 fractions of 3.8 Gy (time interval: 1 week, n = 60, group I) or 2 fractions of 7.2 Gy (time interval: 3 weeks, n = 82, group II) endobronchial HDR-BT.Age, gender, tumor stage, Karnofsky Performance Score and histology were equally distributed between both groups. Local tumor response with 2 fractions of 7.2 Gy was significantly higher as compared to 4 fractions of 3.8 Gy (median 12 vs. 6 weeks; p ≤ 0.015). Median survival was similar in both groups (19 weeks in the 4 fractions group vs. 18 weeks in the 2 fractions group). Fatal hemoptysis was less frequent following irradiation with 2 × 7.2 Gy than with 4 × 3.8 Gy, although the difference did not achieve statistical significance (12.2% vs. 18.3%, respectively. p = 0,345). Patients presenting with squamous cell carcinoma were at higher risk of bleeding compared to other histology (21.9% vs. 9%, p = 0,035).Multivariate analysis with regard to overall survival, revealed histology (p = 0.02), Karnofsky Performance Score (p < 0.0001) and response to therapy (p < 0.0001) as significant prognostic factors. For patients showing complete response the median survival was 57 weeks, while for patients with progressive disease median survival time was 8 weeks, p < 0.0001.The KPS at the start of the treatment was significantly correlated with survival. Patients presenting with a KPS ≤ 60 at the start had a significantly (p = 0,032) shorter survival time (10 weeks) than

  20. Application of Adenosine Triphosphate Affinity Probe and Scheduled Multiple-Reaction Monitoring Analysis for Profiling Global Kinome in Human Cells in Response to Arsenite Treatment

    PubMed Central

    2015-01-01

    Phosphorylation of cellular components catalyzed by kinases plays important roles in cell signaling and proliferation. Quantitative assessment of perturbation in global kinome may provide crucial knowledge for elucidating the mechanisms underlying the cytotoxic effects of environmental toxicants. Here, we utilized an adenosine triphosphate (ATP) affinity probe coupled with stable isotope labeling by amino acids in cell culture (SILAC) to assess quantitatively the arsenite-induced alteration of global kinome in human cells. We constructed a SILAC-compatible kinome library for scheduled multiple-reaction monitoring (MRM) analysis and adopted on-the-fly recalibration of retention time shift, which provided better throughput of the analytical method and enabled the simultaneous quantification of the expression of ∼300 kinases in two LC-MRM runs. With this improved analytical method, we conducted an in-depth quantitative analysis of the perturbation of kinome of GM00637 human skin fibroblast cells induced by arsenite exposure. Several kinases involved in cell cycle progression, including cyclin-dependent kinases (CDK1 and CDK4) and Aurora kinases A, B, and C, were found to be hyperactivated, and the altered expression of CDK1 was further validated by Western analysis. In addition, treatment with a CDK inhibitor, flavopiridol, partially restored the arsenite-induced growth inhibition of human skin fibroblast cells. Thus, sodium arsenite may confer its cytotoxic effect partly through the aberrant activation of CDKs and the resultant perturbation of cell cycle progression. Together, we developed a high-throughput, SILAC-compatible, and MRM-based kinome profiling method and demonstrated that the method is powerful in deciphering the molecular modes of action of a widespread environmental toxicant. The method should be generally applicable for uncovering the cellular pathways triggered by other extracellular stimuli. PMID:25301106

  1. 40 CFR 141.702 - Sampling schedules.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 141.702 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) NATIONAL PRIMARY DRINKING WATER REGULATIONS Enhanced Treatment for Cryptosporidium Source Water Monitoring Requirements § 141.702 Sampling schedules. (a) Systems required to conduct source water...

  2. 40 CFR 141.702 - Sampling schedules.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 141.702 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) NATIONAL PRIMARY DRINKING WATER REGULATIONS Enhanced Treatment for Cryptosporidium Source Water Monitoring Requirements § 141.702 Sampling schedules. (a) Systems required to conduct source water monitoring...

  3. 40 CFR 141.702 - Sampling schedules.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 141.702 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) NATIONAL PRIMARY DRINKING WATER REGULATIONS Enhanced Treatment for Cryptosporidium Source Water Monitoring Requirements § 141.702 Sampling schedules. (a) Systems required to conduct source water monitoring...

  4. 40 CFR 141.702 - Sampling schedules.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 141.702 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) NATIONAL PRIMARY DRINKING WATER REGULATIONS Enhanced Treatment for Cryptosporidium Source Water Monitoring Requirements § 141.702 Sampling schedules. (a) Systems required to conduct source water monitoring...

  5. 40 CFR 141.702 - Sampling schedules.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 141.702 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) NATIONAL PRIMARY DRINKING WATER REGULATIONS Enhanced Treatment for Cryptosporidium Source Water Monitoring Requirements § 141.702 Sampling schedules. (a) Systems required to conduct source water monitoring...

  6. Alternative Work Schedules Increase Employee Satisfaction.

    ERIC Educational Resources Information Center

    Turney, John R.; Cohen, Stanley L.

    1983-01-01

    Facets of alternative work schedules (AWS) are discussed: importance of employee control, possible negative consequences, AWS handbook, time monitoring systems, and treatment of exceptions. AWS' effect on productivity and motivation is examined. (SK)

  7. Schedule-Organizer Computer Program

    NASA Technical Reports Server (NTRS)

    Collazo, Fernando F.

    1990-01-01

    Schedule Organizer provides simple method for generating distribution lists. Contains readers' names for each task schedule defined by input files. Schedule Organizer (SO), Schedule Tracker (ST) (COSMIC program MSC-21526), and Schedule Report Generator (SRG) (COSMIC program MSC-21527) computer programs manipulating data-base files in ways advantageous in scheduling. Written in PL/1 and DEC Command Language (DCL).

  8. Transit scheduling: Basic and advanced manuals. Final report

    SciTech Connect

    Pine, R.; Niemeyer, J.; Chisholm, R.

    1998-12-01

    This manual will be of interest to new transit schedulers, experienced schedulers, transit planners, operating staff, and others who need to be conversant with the scheduling process. The materials clearly describe all steps in the bus and light rail scheduling process, under TCRP Project A-11, Transit Scheduling: A Manual with Materials, research was undertaken by Transportation Management and Design of Solana Beach, California, to prepare a transit scheduling manual that incorporates modern training techniques for bus and light rail transit scheduling. The manual consists of two sections: a basic treatment and an advanced section. The basic-level section is in an instructional format designed primarily for novice schedulers and other transit staff. The advance section covers more complex scheduling requirements. Each section may be used sequentially or independently and is designed to integrate with agency apprenticeship and on-the-job training.

  9. Integrated resource scheduling in a distributed scheduling environment

    NASA Technical Reports Server (NTRS)

    Zoch, David; Hall, Gardiner

    1988-01-01

    The Space Station era presents a highly-complex multi-mission planning and scheduling environment exercised over a highly distributed system. In order to automate the scheduling process, customers require a mechanism for communicating their scheduling requirements to NASA. A request language that a remotely-located customer can use to specify his scheduling requirements to a NASA scheduler, thus automating the customer-scheduler interface, is described. This notation, Flexible Envelope-Request Notation (FERN), allows the user to completely specify his scheduling requirements such as resource usage, temporal constraints, and scheduling preferences and options. The FERN also contains mechanisms for representing schedule and resource availability information, which are used in the inter-scheduler inconsistency resolution process. Additionally, a scheduler is described that can accept these requests, process them, generate schedules, and return schedule and resource availability information to the requester. The Request-Oriented Scheduling Engine (ROSE) was designed to function either as an independent scheduler or as a scheduling element in a network of schedulers. When used in a network of schedulers, each ROSE communicates schedule and resource usage information to other schedulers via the FERN notation, enabling inconsistencies to be resolved between schedulers. Individual ROSE schedules are created by viewing the problem as a constraint satisfaction problem with a heuristically guided search strategy.

  10. Integrated resource scheduling in a distributed scheduling environment

    NASA Technical Reports Server (NTRS)

    Zoch, David; Hall, Gardiner

    1988-01-01

    The Space Station era presents a highly-complex multi-mission planning and scheduling environment exercised over a highly distributed system. In order to automate the scheduling process, customers require a mechanism for communicating their scheduling requirements to NASA. A request language that a remotely-located customer can use to specify his scheduling requirements to a NASA scheduler, thus automating the customer-scheduler interface, is described. This notation, Flexible Envelope-Request Notation (FERN), allows the user to completely specify his scheduling requirements such as resource usage, temporal constraints, and scheduling preferences and options. The FERN also contains mechanisms for representing schedule and resource availability information, which are used in the inter-scheduler inconsistency resolution process. Additionally, a scheduler is described that can accept these requests, process them, generate schedules, and return schedule and resource availability information to the requester. The Request-Oriented Scheduling Engine (ROSE) was designed to function either as an independent scheduler or as a scheduling element in a network of schedulers. When used in a network of schedulers, each ROSE communicates schedule and resource usage information to other schedulers via the FERN notation, enabling inconsistencies to be resolved between schedulers. Individual ROSE schedules are created by viewing the problem as a constraint satisfaction problem with a heuristically guided search strategy.

  11. Automated telescope scheduling

    NASA Astrophysics Data System (ADS)

    Johnston, Mark D.

    1988-08-01

    With the ever increasing level of automation of astronomical telescopes the benefits and feasibility of automated planning and scheduling are becoming more apparent. Improved efficiency and increased overall telescope utilization are the most obvious goals. Automated scheduling at some level has been done for several satellite observatories, but the requirements on these systems were much less stringent than on modern ground or satellite observatories. The scheduling problem is particularly acute for Hubble Space Telescope: virtually all observations must be planned in excruciating detail weeks to months in advance. Space Telescope Science Institute has recently made significant progress on the scheduling problem by exploiting state-of-the-art artificial intelligence software technology. What is especially interesting is that this effort has already yielded software that is well suited to scheduling groundbased telescopes, including the problem of optimizing the coordinated scheduling of more than one telescope.

  12. Automated telescope scheduling

    NASA Technical Reports Server (NTRS)

    Johnston, Mark D.

    1988-01-01

    With the ever increasing level of automation of astronomical telescopes the benefits and feasibility of automated planning and scheduling are becoming more apparent. Improved efficiency and increased overall telescope utilization are the most obvious goals. Automated scheduling at some level has been done for several satellite observatories, but the requirements on these systems were much less stringent than on modern ground or satellite observatories. The scheduling problem is particularly acute for Hubble Space Telescope: virtually all observations must be planned in excruciating detail weeks to months in advance. Space Telescope Science Institute has recently made significant progress on the scheduling problem by exploiting state-of-the-art artificial intelligence software technology. What is especially interesting is that this effort has already yielded software that is well suited to scheduling groundbased telescopes, including the problem of optimizing the coordinated scheduling of more than one telescope.

  13. Optimal outpatient appointment scheduling.

    PubMed

    Kaandorp, Guido C; Koole, Ger

    2007-09-01

    In this paper optimal outpatient appointment scheduling is studied. A local search procedure is derived that converges to the optimal schedule with a weighted average of expected waiting times of patients, idle time of the doctor and tardiness (lateness) as objective. No-shows are allowed to happen. For certain combinations of parameters the well-known Bailey-Welch rule is found to be the optimal appointment schedule.

  14. Randomised phase 3 open-label trial of first-line treatment with gemcitabine in association with docetaxel or paclitaxel in women with metastatic breast cancer: a comparison of different schedules and treatments

    PubMed Central

    2013-01-01

    Background This open-label study compared docetaxel/gemcitabine vs. paclitaxel/gemcitabine and a weekly (W) vs. 3-weekly (3 W) schedule in metastatic breast cancer (MBC). Methods Patients relapsed after adjuvant/neoadjuvant anthracycline-containing chemotherapy were randomized to: A) gemcitabine 1000 mg/m2 Day 1,8 + docetaxel 75 mg/m2 Day 1 q3W; B) gemcitabine 1250 mg/m2 Day 1,8 + paclitaxel 175 mg/m2 Day 1 q3W; C) gemcitabine 800 mg/m2 Day 1,8,15 + docetaxel 30 mg/m2 Day 1,8,15 q4W; D) gemcitabine 800 mg/m2 Day 1,15 + paclitaxel 80 mg/m2 Day 1,8,15 q4W. Primary endpoint was time-to-progression (TTP). Secondary endpoints were overall survival (OS) and overall response rate (ORR). Results Interim analysis led to accrual interruption (241 patients enrolled of 360 planned). Median TTP (months) was 8.33 (95% CI: 6.19-10.16) with W and 7.51 (95% CI: 5.93-8.33) with 3 W (p=0.319). No differences were observed in median TTP between docetaxel and paclitaxel, with 85.6% and 87.0% of patients progressing, respectively. OS did not differ between regimens/schedules. ORR was comparable between regimens (HR: 0.882; 95% CI: 0.523-1.488; p=0.639), while it was significantly higher in W than in the 3 W (HR: 0.504; 95% CI: 0.299-0.850; p=0.010) schedule. Grade 3/4 toxicities occurred in 69.2% and 71.9% of patients on docetaxel and paclitaxel, and in 65.8% and 75.2% in W and 3 W. Conclusions Both treatment regimens showed similar TTP. W might be associated with a better tumour response compared with 3 W. Trial registration Clinicaltrial.gov ID NCT00236899 PMID:23537313

  15. Operational VGOS Scheduling

    NASA Astrophysics Data System (ADS)

    Searle, Anthony; Petrachenko, Bill

    2016-12-01

    The VLBI Global Observing System (VGOS) has been designed to take advantage of advances in data recording speeds and storage capacity, allowing for smaller and faster antennas, wider bandwidths, and shorter observation durations. Here, schedules for a ``realistic" VGOS network, frequency sequences, and expanded source lists are presented using a new source-based scheduling algorithm. The VGOS aim for continuous observations presents new operational challenges. As the source-based strategy is independent of the observing network, there are operational advantages which allow for more flexible scheduling of continuous VLBI observations. Using VieVS, simulations of several schedules are presented and compared with previous VGOS studies.

  16. Kept clinical visits, as scheduled in the first 6 months of antiretroviral treatment, determine long-term treatment outcomes in people living with HIV: a large retrospective cohort study in China.

    PubMed

    Su, Shu; Mao, Limin; He, Jianmei; Wei, Xiuqing; Jing, Jun; Chen, Xi; Zhang, Lei

    2017-09-14

    Background: Routine HIV clinical monitoring is vital for people living with HIV (PLHIV) after treatment initiation. The relationship between clinical visits during the first 6 months after initial antiretroviral therapy (ART) and long-term, HIV-related mortality and service retention was investigated. Methods: A retrospective ART observational research database was established based on de-identified data extracted from 6959 records of adult HIV-positive registrants held by Hunan CDC (Center for Disease Control and Prevention) between 2003 and 2013. Results: During the first 6 months of initiation into ART, 2364 (34.0%) of PLHIV had completed four scheduled visits, meeting the Chinese ART clinical monitoring standards. From 6 months onwards (up to 36 months), this group had the lowest HIV-related mortality (4.4%) compared with those who had more or less than four kept visits in the first 6 months [one visit only: adjusted hazards ratio (AHR)=3.15, 95% CI 2.24-3.88; two visits: AHR=2.24, 95% CI 1.80-3.01; three visits: AHR=1.86, 95% CI 1.69-2.05; and >4 visits: AHR=1.37, 95% CI 1.11-1.72]. Those with less than three kept visits were also at increased risk of cohort loss to follow up (ART discontinuation, prolonged service disengagement or death). A myriad of personal, clinical and social factors are identified to be associated with increased HIV-related mortality and clinical retention. Conclusions: Enabling PLHIV to complete four scheduled clinical visits during the first 6 months of ART initiation, as recommended by the Chinese CDC, is critical.

  17. 19 CFR 162.45 - Summary forfeiture: Property other than Schedule I and Schedule II controlled substances. Notice...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... and Schedule II controlled substances. Notice of seizure and sale. 162.45 Section 162.45 Customs... (CONTINUED) INSPECTION, SEARCH, AND SEIZURE Treatment of Seized Merchandise § 162.45 Summary forfeiture: Property other than Schedule I and Schedule II controlled substances. Notice of seizure and sale. (a...

  18. 19 CFR 162.45 - Summary forfeiture: Property other than Schedule I and Schedule II controlled substances. Notice...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... and Schedule II controlled substances. Notice of seizure and sale. 162.45 Section 162.45 Customs... (CONTINUED) INSPECTION, SEARCH, AND SEIZURE Treatment of Seized Merchandise § 162.45 Summary forfeiture: Property other than Schedule I and Schedule II controlled substances. Notice of seizure and sale. (a...

  19. 19 CFR 162.45 - Summary forfeiture: Property other than Schedule I and Schedule II controlled substances. Notice...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... and Schedule II controlled substances. Notice of seizure and sale. 162.45 Section 162.45 Customs... (CONTINUED) INSPECTION, SEARCH, AND SEIZURE Treatment of Seized Merchandise § 162.45 Summary forfeiture: Property other than Schedule I and Schedule II controlled substances. Notice of seizure and sale. (a...

  20. 19 CFR 162.45 - Summary forfeiture: Property other than Schedule I and Schedule II controlled substances. Notice...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... and Schedule II controlled substances. Notice of seizure and sale. 162.45 Section 162.45 Customs... (CONTINUED) INSPECTION, SEARCH, AND SEIZURE Treatment of Seized Merchandise § 162.45 Summary forfeiture: Property other than Schedule I and Schedule II controlled substances. Notice of seizure and sale. (a...

  1. Scheduling: Seven Period Day

    ERIC Educational Resources Information Center

    Williamson, Ronald

    2010-01-01

    Driven by stable or declining financial resources many school districts are considering the costs and benefits of a seven-period day. While there is limited evidence that any particular scheduling model has a greater impact on student learning than any other, it is clear that the school schedule is a tool that can significantly impact teacher…

  2. Alternative Work Schedules: Definitions

    ERIC Educational Resources Information Center

    Journal of the College and University Personnel Association, 1977

    1977-01-01

    The term "alternative work schedules" encompasses any variation of the requirement that all permanent employees in an organization or one shift of employees adhere to the same five-day, seven-to-eight-hour schedule. This article defines staggered hours, flexible working hours (flexitour and gliding time), compressed work week, the task system, and…

  3. DSN Resource Scheduling

    NASA Technical Reports Server (NTRS)

    Wang, Yeou-Fang; Baldwin, John

    2007-01-01

    TIGRAS is client-side software, which provides tracking-station equipment planning, allocation, and scheduling services to the DSMS (Deep Space Mission System). TIGRAS provides functions for schedulers to coordinate the DSN (Deep Space Network) antenna usage time and to resolve the resource usage conflicts among tracking passes, antenna calibrations, maintenance, and system testing activities. TIGRAS provides a fully integrated multi-pane graphical user interface for all scheduling operations. This is a great improvement over the legacy VAX VMS command line user interface. TIGRAS has the capability to handle all DSN resource scheduling aspects from long-range to real time. TIGRAS assists NASA mission operations for DSN tracking of station equipment resource request processes from long-range load forecasts (ten years or longer), to midrange, short-range, and real-time (less than one week) emergency tracking plan changes. TIGRAS can be operated by NASA mission operations worldwide to make schedule requests for the DSN station equipment.

  4. NASA Schedule Management Handbook

    NASA Technical Reports Server (NTRS)

    2011-01-01

    The purpose of schedule management is to provide the framework for time-phasing, resource planning, coordination, and communicating the necessary tasks within a work effort. The intent is to improve schedule management by providing recommended concepts, processes, and techniques used within the Agency and private industry. The intended function of this handbook is two-fold: first, to provide guidance for meeting the scheduling requirements contained in NPR 7120.5, NASA Space Flight Program and Project Management Requirements, NPR 7120.7, NASA Information Technology and Institutional Infrastructure Program and Project Requirements, NPR 7120.8, NASA Research and Technology Program and Project Management Requirements, and NPD 1000.5, Policy for NASA Acquisition. The second function is to describe the schedule management approach and the recommended best practices for carrying out this project control function. With regards to the above project management requirements documents, it should be noted that those space flight projects previously established and approved under the guidance of prior versions of NPR 7120.5 will continue to comply with those requirements until project completion has been achieved. This handbook will be updated as needed, to enhance efficient and effective schedule management across the Agency. It is acknowledged that most, if not all, external organizations participating in NASA programs/projects will have their own internal schedule management documents. Issues that arise from conflicting schedule guidance will be resolved on a case by case basis as contracts and partnering relationships are established. It is also acknowledged and understood that all projects are not the same and may require different levels of schedule visibility, scrutiny and control. Project type, value, and complexity are factors that typically dictate which schedule management practices should be employed.

  5. Computerizing the Reference Desk Schedule.

    ERIC Educational Resources Information Center

    deHaas, Pat

    1983-01-01

    Discussion of the scheduling procedures of librarians' hours at the reference desk at the Rutherford Humanities and Social Sciences Library, University of Alberta, highlights services provided, the preference table system, and manual scheduling versus computer scheduling. (EJS)

  6. Registration Review Schedules

    EPA Pesticide Factsheets

    This schedule indicates plans for completion of risk assessments, proposed interim decisions and interim decisions for pesticides in the Registration Review program, EPA reviews all registered pesticides at least every 15 years as required by FIFRA.

  7. Childhood Vaccine Schedule

    MedlinePlus

    ... Navigation Bar Home Current Issue Past Issues Childhood Vaccine Schedule Past Issues / Spring 2008 Table of Contents ... please turn Javascript on. When to Vaccinate What Vaccine Why Birth (or any age if not previously ...

  8. Distributed network scheduling

    NASA Technical Reports Server (NTRS)

    Clement, Bradley J.; Schaffer, Steven R.

    2004-01-01

    Distributed Network Scheduling is the scheduling of future communications of a network by nodes in the network. This report details software for doing this onboard spacecraft in a remote network. While prior work on distributed scheduling has been applied to remote spacecraft networks, the software reported here focuses on modeling communication activities in greater detail and including quality of service constraints. Our main results are based on a Mars network of spacecraft and include identifying a maximum opportunity of improving traverse exploration rate a factor of three; a simulation showing reduction in one-way delivery times from a rover to Earth from as much as 5 to 1.5 hours; simulated response to unexpected events averaging under an hour onboard; and ground schedule generation ranging from seconds to 50 minutes for 15 to 100 communication goals.

  9. Initial Hardware Development Schedule

    NASA Technical Reports Server (NTRS)

    Culpepper, William X.

    1991-01-01

    The hardware development schedule for the Common Lunar Lander's (CLLs) tracking system is presented. Among the topics covered are the following: historical perspective, solution options, industry contacts, and the rationale for selection.

  10. Pushing schedule derivation method

    SciTech Connect

    Henriquez, B.

    1996-12-31

    The development of a Pushing Schedule Derivation Method has allowed the company to sustain the maximum production rate at CSH`s Coke Oven Battery, in spite of having single set oven machinery with a high failure index as well as a heat top tendency. The stated method provides for scheduled downtime of up to two hours for machinery maintenance purposes, periods of empty ovens for decarbonization and production loss recovery capability, while observing lower limits and uniformity of coking time.

  11. Affirmative Action: The Scheduled Castes and the Scheduled Tribes.

    ERIC Educational Resources Information Center

    Sivaramayya, B.

    This paper considers Indian affirmative action policies that provide reservations (quotas) in favor of two disadvantaged groups, the scheduled castes and the scheduled tribes. First, definitions and background are presented. The scheduled castes ("untouchables") are said to suffer from social segregation, and the scheduled tribes from…

  12. Comparing Pictorial and Video Modeling Activity Schedules during Transitions for Students with Autism Spectrum Disorders

    ERIC Educational Resources Information Center

    Cihak, David F.

    2011-01-01

    This study evaluated the differential effects of two different visual schedule strategies. In the context of an alternating treatments design, static-picture schedules were compared to video based activity schedules as supports for three middle school aged students with autism. Students used the visual schedules to transition between activities in…

  13. Comparing Pictorial and Video-Modeling Activity Schedules during Transitions for Students with Autism Spectrum Disorders

    ERIC Educational Resources Information Center

    Cihak, David F.; Ayres, Kevin M.

    2010-01-01

    This study evaluated the differential effects of two different visual schedule strategies. In the context of an alternating treatments design, static-picture schedules were compared to video based activity schedules as supports for three middle school aged students with autism. Students used the visual schedules to transition between activities in…

  14. Quantitative analysis of performance on a progressive-ratio schedule: effects of reinforcer type, food deprivation and acute treatment with Δ⁹-tetrahydrocannabinol (THC).

    PubMed

    Olarte-Sánchez, C M; Valencia-Torres, L; Cassaday, H J; Bradshaw, C M; Szabadi, E

    2015-04-01

    Rats' performance on a progressive-ratio schedule maintained by sucrose (0.6M, 50 μl) and corn oil (100%, 25 μl) reinforcers was assessed using a model derived from Killeen's (1994) theory of schedule-controlled behaviour, 'Mathematical Principles of Reinforcement'. When the rats were maintained at 80% of their free-feeding body weights, the parameter expressing incentive value, a, was greater for the corn oil than for the sucrose reinforcer; the response-time parameter, δ, did not differ between the reinforcer types, but a parameter derived from the linear waiting principle (T0), indicated that the minimum post-reinforcement pause was longer for corn oil than for sucrose. When the rats were maintained under free-feeding conditions, a was reduced, indicating a reduction of incentive value, but δ was unaltered. Under the food-deprived condition, the CB1 cannabinoid receptor agonist Δ(9)-tetrahydrocannabinol (THC: 0.3, 1 and 3 mg kg(-1)) increased the value of a for sucrose but not for corn oil, suggesting a selective enhancement of the incentive value of sucrose; none of the other parameters was affected by THC. The results provide new information about the sensitivity of the model's parameters to deprivation and reinforcer quality, and suggest that THC selectively enhances the incentive value of sucrose.

  15. The Stanford School Scheduling System.

    ERIC Educational Resources Information Center

    Stanford Univ., CA. Dept. of Industrial Engineering.

    This booklet gives a general overview of the computerized Stanford School Scheduling System (SSSS) which is designed to make scheduling less difficult for individualized programs in secondary education. Topics covered include new flexible scheduling and variable course structure designs in secondary education, the school scheduling problem,…

  16. Constraint-based scheduling

    NASA Technical Reports Server (NTRS)

    Zweben, Monte

    1991-01-01

    The GERRY scheduling system developed by NASA Ames with assistance from the Lockheed Space Operations Company, and the Lockheed Artificial Intelligence Center, uses a method called constraint based iterative repair. Using this technique, one encodes both hard rules and preference criteria into data structures called constraints. GERRY repeatedly attempts to improve schedules by seeking repairs for violated constraints. The system provides a general scheduling framework which is being tested on two NASA applications. The larger of the two is the Space Shuttle Ground Processing problem which entails the scheduling of all inspection, repair, and maintenance tasks required to prepare the orbiter for flight. The other application involves power allocations for the NASA Ames wind tunnels. Here the system will be used to schedule wind tunnel tests with the goal of minimizing power costs. In this paper, we describe the GERRY system and its applications to the Space Shuttle problem. We also speculate as to how the system would be used for manufacturing, transportation, and military problems.

  17. Constraint-based scheduling

    NASA Technical Reports Server (NTRS)

    Zweben, Monte

    1991-01-01

    The GERRY scheduling system developed by NASA Ames with assistance from the Lockheed Space Operations Company, and the Lockheed Artificial Intelligence Center, uses a method called constraint-based iterative repair. Using this technique, one encodes both hard rules and preference criteria into data structures called constraints. GERRY repeatedly attempts to improve schedules by seeking repairs for violated constraints. The system provides a general scheduling framework which is being tested on two NASA applications. The larger of the two is the Space Shuttle Ground Processing problem which entails the scheduling of all the inspection, repair, and maintenance tasks required to prepare the orbiter for flight. The other application involves power allocation for the NASA Ames wind tunnels. Here the system will be used to schedule wind tunnel tests with the goal of minimizing power costs. In this paper, we describe the GERRY system and its application to the Space Shuttle problem. We also speculate as to how the system would be used for manufacturing, transportation, and military problems.

  18. Constraint-based scheduling

    NASA Technical Reports Server (NTRS)

    Zweben, Monte

    1993-01-01

    The GERRY scheduling system developed by NASA Ames with assistance from the Lockheed Space Operations Company, and the Lockheed Artificial Intelligence Center, uses a method called constraint-based iterative repair. Using this technique, one encodes both hard rules and preference criteria into data structures called constraints. GERRY repeatedly attempts to improve schedules by seeking repairs for violated constraints. The system provides a general scheduling framework which is being tested on two NASA applications. The larger of the two is the Space Shuttle Ground Processing problem which entails the scheduling of all the inspection, repair, and maintenance tasks required to prepare the orbiter for flight. The other application involves power allocation for the NASA Ames wind tunnels. Here the system will be used to schedule wind tunnel tests with the goal of minimizing power costs. In this paper, we describe the GERRY system and its application to the Space Shuttle problem. We also speculate as to how the system would be used for manufacturing, transportation, and military problems.

  19. Reinforcement Schedule Thinning Following Functional Communication Training: Review and Recommendations

    PubMed Central

    Hagopian, Louis P; Boelter, Eric W; Jarmolowicz, David P

    2011-01-01

    This paper extends the Tiger, Hanley, and Bruzek (2008) review of functional communication training (FCT) by reviewing the published literature on reinforcement schedule thinning following FCT. As noted by Tiger et al. and others, schedule thinning may be necessary when the newly acquired communication response occurs excessively, to the extent that reinforcing it consistently is not practical in the natural environment. We provide a review of this literature including a discussion of each of the more commonly used schedule arrangements used for this purpose, outcomes obtained, a description of methods for progressing toward the terminal schedule, and a description of supplemental treatment components aimed at maintaining low levels of problem behavior during schedule thinning. Recommendations for schedule thinning are then provided. Finally, conceptual issues related to the reemergence of problem behavior during schedule thinning and areas for future research are discussed. PMID:22532899

  20. Schedule of voucher delivery influences initiation of cocaine abstinence.

    PubMed

    Kirby, K C; Marlowe, D B; Festinger, D S; Lamb, R J; Platt, J J

    1998-10-01

    This study examined whether voucher delivery arrangements affect treatment outcome. First, 90 cocaine-dependent adults were randomly assigned to behavioral counseling or counseling plus vouchers for cocaine-free urine samples. The value of each voucher was low at the beginning but increased as the patient progressed (Voucher Schedule 1). Voucher Schedule 1 produced no improvements relative to counseling only. Next, 23 patients received vouchers on either Voucher Schedule 1 or Voucher Schedule 2. Voucher Schedule 2 began with high voucher values, but requirements for earning vouchers increased as the patient progressed. Average durations of cocaine abstinence were 6.9 weeks on Voucher Schedule 2 versus 2.0 weeks on Voucher Schedule 1 (p = .02). This confirms that vouchers can assist in initiating abstinence and that voucher delivery arrangements are critical.

  1. Automated Scheduling Via Artificial Intelligence

    NASA Technical Reports Server (NTRS)

    Biefeld, Eric W.; Cooper, Lynne P.

    1991-01-01

    Artificial-intelligence software that automates scheduling developed in Operations Mission Planner (OMP) research project. Software used in both generation of new schedules and modification of existing schedules in view of changes in tasks and/or available resources. Approach based on iterative refinement. Although project focused upon scheduling of operations of scientific instruments and other equipment aboard spacecraft, also applicable to such terrestrial problems as scheduling production in factory.

  2. Automated Scheduling Via Artificial Intelligence

    NASA Technical Reports Server (NTRS)

    Biefeld, Eric W.; Cooper, Lynne P.

    1991-01-01

    Artificial-intelligence software that automates scheduling developed in Operations Mission Planner (OMP) research project. Software used in both generation of new schedules and modification of existing schedules in view of changes in tasks and/or available resources. Approach based on iterative refinement. Although project focused upon scheduling of operations of scientific instruments and other equipment aboard spacecraft, also applicable to such terrestrial problems as scheduling production in factory.

  3. Schedule-Tracker Computer Program

    NASA Technical Reports Server (NTRS)

    Collazo, Fernando F.

    1990-01-01

    Schedule Tracker provides effective method for tracking tasks "past due" and/or "near term". Generates reports for each responsible staff member having one or more assigned tasks falling within two listed categories. Schedule Organizer (SO) (COSMIC program MSC-21525), Schedule Tracker (ST), and Schedule Report Generator (SRG) (COSMIC program MSC-21527) computer programs manipulating data-base files in ways advantageous in scheduling. Written in PL/1 and DEC Command Language (DCL).

  4. Are accidents scheduled. [safety management problems

    NASA Technical Reports Server (NTRS)

    Childs, C.

    1976-01-01

    Two major sets of safety problems associated with project scheduling are examined. The first set involves problems resulting from the improper scheduling of the safety tasks. The second involves problems which result from inadequate attention to scheduling of those project tasks which lead to tests and operations and includes condensed schedules, modified schedules, schedule workarounds, eliminated portions of the schedules and strung out schedules.

  5. Scheduling with genetic algorithms

    NASA Technical Reports Server (NTRS)

    Fennel, Theron R.; Underbrink, A. J., Jr.; Williams, George P. W., Jr.

    1994-01-01

    In many domains, scheduling a sequence of jobs is an important function contributing to the overall efficiency of the operation. At Boeing, we develop schedules for many different domains, including assembly of military and commercial aircraft, weapons systems, and space vehicles. Boeing is under contract to develop scheduling systems for the Space Station Payload Planning System (PPS) and Payload Operations and Integration Center (POIC). These applications require that we respect certain sequencing restrictions among the jobs to be scheduled while at the same time assigning resources to the jobs. We call this general problem scheduling and resource allocation. Genetic algorithms (GA's) offer a search method that uses a population of solutions and benefits from intrinsic parallelism to search the problem space rapidly, producing near-optimal solutions. Good intermediate solutions are probabalistically recombined to produce better offspring (based upon some application specific measure of solution fitness, e.g., minimum flowtime, or schedule completeness). Also, at any point in the search, any intermediate solution can be accepted as a final solution; allowing the search to proceed longer usually produces a better solution while terminating the search at virtually any time may yield an acceptable solution. Many processes are constrained by restrictions of sequence among the individual jobs. For a specific job, other jobs must be completed beforehand. While there are obviously many other constraints on processes, it is these on which we focussed for this research: how to allocate crews to jobs while satisfying job precedence requirements and personnel, and tooling and fixture (or, more generally, resource) requirements.

  6. Intelligent retail logistics scheduling

    SciTech Connect

    Rowe, J.; Jewers, K.; Codd, A.; Alcock, A.

    1996-12-31

    The Supply Chain Integrated Ordering Network (SCION) Depot Bookings system automates the planning and scheduling of perishable and non-perishable commodities and the vehicles that carry them into J. Sainsbury depots. This is a strategic initiative, enabling the business to make the key move from weekly to daily ordering. The system is mission critical, managing the inwards flow of commodities from suppliers into J. Sainsbury`s depots. The system leverages Al techniques to provide a business solution that meets challenging functional and performance needs. The SCION Depot Bookings system is operational providing schedules for 22 depots across the UK.

  7. A comparison of procedures for programming noncontingent reinforcement schedules.

    PubMed

    Kahng, S W; Iwata, B A; DeLeon, I G; Wallace, M D

    2000-01-01

    We compared two methods for programming and thinning noncontingent reinforcement (NCR) schedules during the treatment of self-injurious behavior (SIB). The participants were 3 individuals who had been diagnosed with mental retardation. Results of functional analyses indicated that all participants' SIB was maintained by positive reinforcement (i.e., access to attention or food). Following baseline, the effects of two NCR schedule-thinning procedures were compared in multielement designs. One schedule (fixed increment) was initially set at fixed-time 10-s reinforcer deliveries and was also thinned according to fixed-time intervals. The other schedule (adjusting IRT) was initially determined by participants' baseline interresponse times (IRTs) for SIB and was thinned based on IRTs observed during subsequent treatment sessions. Results indicated that both schedules were effective in initially reducing SIB and in maintaining response suppression as the schedules were thinned.

  8. CMS multicore scheduling strategy

    SciTech Connect

    Perez-Calero Yzquierdo, Antonio; Hernandez, Jose; Holzman, Burt; Majewski, Krista; McCrea, Alison

    2014-01-01

    In the next years, processor architectures based on much larger numbers of cores will be most likely the model to continue 'Moore's Law' style throughput gains. This not only results in many more jobs in parallel running the LHC Run 1 era monolithic applications, but also the memory requirements of these processes push the workernode architectures to the limit. One solution is parallelizing the application itself, through forking and memory sharing or through threaded frameworks. CMS is following all of these approaches and has a comprehensive strategy to schedule multicore jobs on the GRID based on the glideinWMS submission infrastructure. The main component of the scheduling strategy, a pilot-based model with dynamic partitioning of resources that allows the transition to multicore or whole-node scheduling without disallowing the use of single-core jobs, is described. This contribution also presents the experiences made with the proposed multicore scheduling schema and gives an outlook of further developments working towards the restart of the LHC in 2015.

  9. Schedule-Induced Stereotypy.

    ERIC Educational Resources Information Center

    Emerson, Eric; Howard, Denise

    1992-01-01

    The phenomena of the induction and entrainment of adjunctive behaviors was investigated in 8 people (ages 5-51) with severe or profound mental retardation who exhibited stereotypic behaviors. Seven of the eight demonstrated evidence of schedule-induced stereotypic behavior, whereas five also showed evidence of the entrainment of these behaviors by…

  10. Optimizing Observation Scheduling Objectives

    NASA Technical Reports Server (NTRS)

    Bresina, John L.; Morris, Robert A.; Edgington, William R.

    1997-01-01

    In this paper, we present an approach that enables the automatic generation of high quality schedules, with respect to a given objective function. The approach involves the combination of two techniques: GenH, which automatically generates a search heuristic specialized to the given problem instance, and HBSS, which employs the generated heuristic as a bias within a stochastic sampling method.

  11. "Creative" Work Schedules.

    ERIC Educational Resources Information Center

    Blai, Boris

    Many creative or flexible work scheduling options are becoming available to the many working parents, students, handicapped persons, elderly individuals, and others who are either unable or unwilling to work a customary 40-hour work week. These options may be broadly categorized as either restructured or reduced work time options. The three main…

  12. Parent Interview Schedule.

    ERIC Educational Resources Information Center

    Purdue Univ., Lafayette, IN. Educational Research Center.

    This 116-item interview schedule designed for parents who failed to respond to the Questionnaire for Parents, is individually administered to the mother of the child of elementary school age. It consists of scales measuring 14 parent variables plus a section devoted to demographic variables: (1) parent's achievement aspirations for the child, (2)…

  13. "Creative" Work Schedules.

    ERIC Educational Resources Information Center

    Blai, Boris

    Many creative or flexible work scheduling options are becoming available to the many working parents, students, handicapped persons, elderly individuals, and others who are either unable or unwilling to work a customary 40-hour work week. These options may be broadly categorized as either restructured or reduced work time options. The three main…

  14. Scheduling Advisory. Research Brief

    ERIC Educational Resources Information Center

    Muir, Mike

    2005-01-01

    More and more high schools are implementing Advisory programs for a variety of reasons: personalization, academics & study skills, life success skills, self-knowledge, addressing the concern about students feeling "lost" in the high school setting, first line of contact for the parents, and portfolios. But finding a way to schedule advisory can…

  15. Scheduling THE Computer.

    ERIC Educational Resources Information Center

    McKay, Martin D.

    1998-01-01

    Focuses on how to schedule the use of a single computer so that all students are represented and given equal access. Suggests that a computer management team be selected from within the class; discusses the teacher's role and student role definition and responsibility assignments. (AEF)

  16. Prescribing Schedule 8 drugs.

    PubMed

    Bird, Sara

    2006-01-01

    Case histories are based on actual medical negligence cases, however certain facts have been omitted or changed by the author to ensure the anonymity of the parties involved. This article examines a general practitioner's legal obligations when prescribing Schedule 8 drugs (drugs of addiction), with particular emphasis on dealing with patients who are drug dependent.

  17. Round Robin Schedules.

    ERIC Educational Resources Information Center

    Iannone, Michael A.

    1983-01-01

    Presented is a computer program written in BASIC that covers round-robin schedules for team matches in competitions. The program was originally created to help teams in a tennis league play one match against every other team. Part of the creation of the program involved use of modulo arithmetic. (MP)

  18. A comparison of dense-to-lean and fixed lean schedules of alternative reinforcement and extinction.

    PubMed Central

    Hagopian, Louis P; Toole, Lisa M; Long, Ethan S; Bowman, Lynn G; Lieving, Gregory A

    2004-01-01

    Behavior-reduction interventions typically employ dense schedules of alternative reinforcement in conjunction with operant extinction for problem behavior. After problem behavior is reduced in the initial treatment stages, schedule thinning is routinely conducted to make the intervention more practical in natural environments. In the current investigation, two methods for thinning alternative reinforcement schedules were compared for 3 clients who exhibited severe problem behavior. In the dense-to-lean (DTL) condition, reinforcement was delivered on relatively dense schedules (using noncontingent reinforcement for 1 participant and functional communication training for 2 participants), followed by systematic schedule thinning to progressively leaner schedules. During the fixed lean (FL) condition, reinforcement was delivered on lean schedules (equivalent to the terminal schedule of the DTL condition). The FL condition produced a quicker attainment of individual treatment goals for 2 of the 3 participants. The results are discussed in terms of the potential utility of using relatively lean schedules at treatment outset. PMID:15529889

  19. A comparison of dense-to-lean and fixed lean schedules of alternative reinforcement and extinction.

    PubMed

    Hagopian, Louis P; Toole, Lisa M; Long, Ethan S; Bowman, Lynn G; Lieving, Gregory A

    2004-01-01

    Behavior-reduction interventions typically employ dense schedules of alternative reinforcement in conjunction with operant extinction for problem behavior. After problem behavior is reduced in the initial treatment stages, schedule thinning is routinely conducted to make the intervention more practical in natural environments. In the current investigation, two methods for thinning alternative reinforcement schedules were compared for 3 clients who exhibited severe problem behavior. In the dense-to-lean (DTL) condition, reinforcement was delivered on relatively dense schedules (using noncontingent reinforcement for 1 participant and functional communication training for 2 participants), followed by systematic schedule thinning to progressively leaner schedules. During the fixed lean (FL) condition, reinforcement was delivered on lean schedules (equivalent to the terminal schedule of the DTL condition). The FL condition produced a quicker attainment of individual treatment goals for 2 of the 3 participants. The results are discussed in terms of the potential utility of using relatively lean schedules at treatment outset.

  20. Phase I and pharmacokinetic trial of carboplatin and albumin-bound paclitaxel, ABI-007 (Abraxane) on three treatment schedules in patients with solid tumors.

    PubMed

    Stinchcombe, Thomas E; Socinski, Mark A; Walko, Christine M; O'Neil, Bert H; Collichio, Frances A; Ivanova, Anastasia; Mu, Hua; Hawkins, Michael J; Goldberg, Richard M; Lindley, Celeste; Dees, E Claire

    2007-10-01

    Albumin-bound paclitaxel, ABI-007 (Abraxane((R))), has a different toxicity profile than solvent-based paclitaxel, including a lower rate of severe neutropenia. The combination of ABI-007 and carboplatin may have significant activity in a variety of tumor types including non-small and small cell lung cancer, ovarian cancer, and breast cancer. The purpose of this study was to determine the maximum tolerated dose (MTD) of ABI-007, on three different schedules in combination with carboplatin. Forty-one patients with solid tumors were enrolled, and received ABI-007 in combination with carboplatin AUC of 6 on day 1. Group A received ABI-007 at doses ranging from 220 to 340 mg/m(2) on day 1 every 21 days; group B received ABI-007 at 100 or 125 mg/m(2) on days 1, 8, and 15 every 28 days; and group C received ABI-007 125 or 150 mg/m(2) on days 1 and 8 every 21 days. Dose-limiting toxicities were assessed after the first cycle. Doses were escalated in cohorts of three to six patients. Fifteen patients participated in a pharmacokinetic study investigating the effects of the sequence of infusion. ABI-007 was infused first followed by carboplatin in cycle 1, and vice versa in cycle 2. The MTD of ABI-007 in combination with carboplatin was 300, 100, and 125 mg/m(2) in groups A, B, and C, respectively. Myelosuppression was the primary dose limiting toxicity. No unexpected or new toxicities were reported. Sequence of infusion did not affect either the pharmacokinetics of ABI-007 or the degree of neutropenia. Responses were seen in melanoma, lung, bladder, esophageal, pancreatic, breast cancer, and cancer of unknown primary. The recommended dose for phase II studies of ABI-007 in combination with carboplatin (AUC of 6) is 300, 100, 125 mg/m(2) for the schedules A, B, and C, respectively. The combination of ABI-007 and carboplatin is well tolerated and active in this heavily pretreated patient population.

  1. Applying a 4D multiscale in vivo tumor growth model to the exploration of radiotherapy scheduling: The effects of weekend treatment gaps and p53 gene status on the response of fast growing solid tumors

    PubMed Central

    Dionysiou, Dimitra D.; Stamatakos, Georgios S.

    2006-01-01

    The present paper aims at demonstrating clinically oriented applications of the multiscale four dimensional in vivo tumor growth simulation model previously developed by our research group. To this end the effect of weekend radiotherapy treatment gaps and p53 gene status on two virtual glioblastoma tumors differing only in p53 gene status is investigated in silico. Tumor response predictions concerning two rather extreme dose fractionation schedules (daily dose of 4.5 Gy administered in 3 equal fractions) namely HART (Hyperfractionated Accelerated Radiotherapy weekend less) 54 Gy and CHART (Continuous HART) 54 Gy are presented and compared. The model predictions suggest that, for the same p53 status, HART 54 Gy and CHART 54 Gy have almost the same long term effects on locoregional tumor control. However, no data have been located in the literature concerning a comparison of HART and CHART radiotherapy schedules for glioblastoma. As non small cell lung carcinoma (NSCLC) may also be a fast growing and radiosensitive tumor, a comparison of the model predictions with the outcome of clinical studies concerning the response of NSCLC to HART 54 Gy and CHART 54 Gy is made. The model predictions are in accordance with corresponding clinical observations, thus strengthening the potential of the model. PMID:19458763

  2. Completable scheduling: An integrated approach to planning and scheduling

    NASA Technical Reports Server (NTRS)

    Gervasio, Melinda T.; Dejong, Gerald F.

    1992-01-01

    The planning problem has traditionally been treated separately from the scheduling problem. However, as more realistic domains are tackled, it becomes evident that the problem of deciding on an ordered set of tasks to achieve a set of goals cannot be treated independently of the problem of actually allocating resources to the tasks. Doing so would result in losing the robustness and flexibility needed to deal with imperfectly modeled domains. Completable scheduling is an approach which integrates the two problems by allowing an a priori planning module to defer particular planning decisions, and consequently the associated scheduling decisions, until execution time. This allows a completable scheduling system to maximize plan flexibility by allowing runtime information to be taken into consideration when making planning and scheduling decision. Furthermore, through the criteria of achievability placed on deferred decision, a completable scheduling system is able to retain much of the goal-directedness and guarantees of achievement afforded by a priori planning. The completable scheduling approach is further enhanced by the use of contingent explanation-based learning, which enables a completable scheduling system to learn general completable plans from example and improve its performance through experience. Initial experimental results show that completable scheduling outperforms classical scheduling as well as pure reactive scheduling in a simple scheduling domain.

  3. Block Schedule and Traditional Schedule Achievement: A Comparison

    ERIC Educational Resources Information Center

    Arnold, Douglas E.

    2002-01-01

    Block scheduling constitutes one of the major types of restructuring considered by school administrators seeking to improve student performance. The relationship between two school schedules--the seven-period A/B block and the seven-period traditional schedule--and achievement of students in grade 11 was examined. Comparisons showed no significant…

  4. Scheduling techniques in the Request Oriented Scheduling Engine (ROSE)

    NASA Technical Reports Server (NTRS)

    Zoch, David R.

    1991-01-01

    Scheduling techniques in the ROSE are presented in the form of the viewgraphs. The following subject areas are covered: agenda; ROSE summary and history; NCC-ROSE task goals; accomplishments; ROSE timeline manager; scheduling concerns; current and ROSE approaches; initial scheduling; BFSSE overview and example; and summary.

  5. Explanation of Registration Review Schedule

    EPA Pesticide Factsheets

    Updated information on EPA's schedule for opening dockets to begin pesticide registration reviews during the next several years. The schedule is subdivided into conventional pesticides, antimicrobials, biochemicals, and microbials.

  6. Registration Review Docket Opening Schedule

    EPA Pesticide Factsheets

    Dockets are opened on a fiscal year schedule for reevaluation of all pesticides. They are subdivided into conventional pesticides, antimicrobials, biochemicals, and microbials. The schedules for 2014 to 2017 are attached.

  7. Methodologies for building robust schedules

    NASA Technical Reports Server (NTRS)

    Dean, John H.

    1992-01-01

    COMPASS is the name of a Computer Aided Scheduling System designed and built for NASA. COMPASS can be used to develop schedule of activities based upon the temporal relationships of the activities and their resource requirements. COMPASS uses this information, and guided by the user, develops precise start and stop times for the activities. In actual practice however, it is impossible to know with complete certainty what the actual durations of the scheduled activities will really be. The best that one can hope for is knowledge of the probability distribution for the durations. This paper investigates methodologies for using a scheduling tool like COMPASS that is based upon definite values for the resource requirements, while building schedules that remain valid in the face of the schedule execution perturbations. Representations for the schedules developed by these methodologies are presented, along with a discussion of the algorithm that could be used by a computer onboard a spacecraft to efficiently monitor and execute these schedules.

  8. Revisiting conjugate schedules.

    PubMed

    MacAleese, Kenneth R; Ghezzi, Patrick M; Rapp, John T

    2015-07-01

    The effects of conjugate reinforcement on the responding of 13 college students were examined in three experiments. Conjugate reinforcement was provided via key presses that changed the clarity of pictures displayed on a computer monitor in a manner proportional to the rate of responding. Experiment 1, which included seven parameters of clarity change per response, revealed that responding decreased as the percentage clarity per response increased for all five participants. These results indicate that each participant's responding was sensitive to intensity change, which is a parameter of conjugate reinforcement schedules. Experiment 2 showed that responding increased during conjugate reinforcement phases and decreased during extinction phases for all four participants. Experiment 3 also showed that responding increased during conjugate reinforcement and further showed that responding decreased during a conjugate negative punishment condition for another four participants. Directions for future research with conjugate schedules are briefly discussed.

  9. Observation Scheduling System

    NASA Technical Reports Server (NTRS)

    Chien, Steve A.; Tran, Daniel Q.; Rabideau, Gregg R.; Schaffer, Steven R.

    2011-01-01

    Software has been designed to schedule remote sensing with the Earth Observing One spacecraft. The software attempts to satisfy as many observation requests as possible considering each against spacecraft operation constraints such as data volume, thermal, pointing maneuvers, and others. More complex constraints such as temperature are approximated to enable efficient reasoning while keeping the spacecraft within safe limits. Other constraints are checked using an external software library. For example, an attitude control library is used to determine the feasibility of maneuvering between pairs of observations. This innovation can deal with a wide range of spacecraft constraints and solve large scale scheduling problems like hundreds of observations and thousands of combinations of observation sequences.

  10. SARDA Surface Schedulers

    NASA Technical Reports Server (NTRS)

    Malik, Waqar

    2016-01-01

    Provide an overview of algorithms used in SARDA (Spot and Runway Departure Advisor) HITL (Human-in-the-Loop) simulation for Dallas Fort-Worth International Airport and Charlotte Douglas International airport. Outline a multi-objective dynamic programming (DP) based algorithm that finds the exact solution to the single runway scheduling (SRS) problem, and discuss heuristics to restrict the search space for the DP based algorithm and provide improvements.

  11. State-based scheduling: An architecture for telescope observation scheduling

    NASA Technical Reports Server (NTRS)

    Muscettola, Nicola; Smith, Stephen F.

    1989-01-01

    The applicability of constraint-based scheduling, a methodology previously developed and validated in the domain of factory scheduling, is extended to problem domains that require attendance to a wider range of state-dependent constraints. The problem of constructing and maintaining a short-term observation schedule for the Hubble Space Telescope (HST), which typifies this type of domain is the focus of interest. The nature of the constraints encountered in the HST domain is examined, system requirements are discussed with respect to utilization of a constraint-based scheduling methodology in such domains, and a general framework for state-based scheduling is presented.

  12. Computational Simulation for Decision of Scheduling Period in Reactive Scheduling

    NASA Astrophysics Data System (ADS)

    Sakaguchi, Tatsuhiko; Kamimura, Toshihide; Shirase, Keiichi

    Unexpected disruptions often occur in the manufacturing systems. The manufacturing systems cannot execute the manufacturing operations in accordance with the predetermined production schedule due to such disruptions. Therefore, a systematic scheduling method is required to cope with such disruptions. In this research, distribution of processing time is described with the normal distribution. The reactive scheduling method for distribution of processing time is proposed in order to modify the predetermined production schedule. And the suitable re-scheduling period is considered through the computational experiments.

  13. FlexMod Scheduling Redux

    ERIC Educational Resources Information Center

    Murray, Shannon

    2008-01-01

    Flexible modular scheduling (flex mod)--a schedule philosophy and system that has been in place at Wausau West High School in Wausau, Wisconsin, for the last 35 years and aligns nicely with current research on student learning--is getting more and more attention from high school administrators across the country. Flexible modular scheduling was…

  14. FlexMod Scheduling Redux

    ERIC Educational Resources Information Center

    Murray, Shannon

    2008-01-01

    Flexible modular scheduling (flex mod)--a schedule philosophy and system that has been in place at Wausau West High School in Wausau, Wisconsin, for the last 35 years and aligns nicely with current research on student learning--is getting more and more attention from high school administrators across the country. Flexible modular scheduling was…

  15. Conflict-Aware Scheduling Algorithm

    NASA Technical Reports Server (NTRS)

    Wang, Yeou-Fang; Borden, Chester

    2006-01-01

    conflict-aware scheduling algorithm is being developed to help automate the allocation of NASA s Deep Space Network (DSN) antennas and equipment that are used to communicate with interplanetary scientific spacecraft. The current approach for scheduling DSN ground resources seeks to provide an equitable distribution of tracking services among the multiple scientific missions and is very labor intensive. Due to the large (and increasing) number of mission requests for DSN services, combined with technical and geometric constraints, the DSN is highly oversubscribed. To help automate the process, and reduce the DSN and spaceflight project labor effort required for initiating, maintaining, and negotiating schedules, a new scheduling algorithm is being developed. The scheduling algorithm generates a "conflict-aware" schedule, where all requests are scheduled based on a dynamic priority scheme. The conflict-aware scheduling algorithm allocates all requests for DSN tracking services while identifying and maintaining the conflicts to facilitate collaboration and negotiation between spaceflight missions. These contrast with traditional "conflict-free" scheduling algorithms that assign tracks that are not in conflict and mark the remainder as unscheduled. In the case where full schedule automation is desired (based on mission/event priorities, fairness, allocation rules, geometric constraints, and ground system capabilities/ constraints), a conflict-free schedule can easily be created from the conflict-aware schedule by removing lower priority items that are in conflict.

  16. Surprise Benefits of Arena Scheduling

    ERIC Educational Resources Information Center

    Surloff, Andrew

    2008-01-01

    One of the most challenging tasks a principal must accomplish every year is the construction of the master schedule. Free from the magnetic scheduling boards and wall charts of yesteryear, principals now have technological tools--such as programs that offer schools solutions for their scheduling needs--that can save time and enable them to work…

  17. Rural Inservice Using Alternate Scheduling.

    ERIC Educational Resources Information Center

    Kimmet, James L.

    Three small rural school districts in Montana and Wyoming used alternate school day scheduling to make time for staff and curriculum development inservice programs. The schedule of one short and four long days delivered the instructional time of 175 6-hour days each year. Benefits of alternate scheduling included time for regular inservice…

  18. Flexible Scheduling: Making the Transition

    ERIC Educational Resources Information Center

    Creighton, Peggy Milam

    2008-01-01

    Citing literature that supports the benefits of flexible scheduling on student achievement, the author exhorts readers to campaign for flexible scheduling in their library media centers. She suggests tips drawn from the work of Graziano (2002), McGregor (2006) and Stripling (1997) for making a smooth transition from fixed to flexible scheduling:…

  19. Surprise Benefits of Arena Scheduling

    ERIC Educational Resources Information Center

    Surloff, Andrew

    2008-01-01

    One of the most challenging tasks a principal must accomplish every year is the construction of the master schedule. Free from the magnetic scheduling boards and wall charts of yesteryear, principals now have technological tools--such as programs that offer schools solutions for their scheduling needs--that can save time and enable them to work…

  20. Automation Improves Schedule Quality and Increases Scheduling Efficiency for Residents

    PubMed Central

    Perelstein, Elizabeth; Rose, Ariella; Hong, Young-Chae; Cohn, Amy; Long, Micah T.

    2016-01-01

    Background Medical resident scheduling is difficult due to multiple rules, competing educational goals, and ever-evolving graduate medical education requirements. Despite this, schedules are typically created manually, consuming hours of work, producing schedules of varying quality, and yielding negative consequences for resident morale and learning. Objective To determine whether computerized decision support can improve the construction of residency schedules, saving time and improving schedule quality. Methods The Optimized Residency Scheduling Assistant was designed by a team from the University of Michigan Department of Industrial and Operations Engineering. It was implemented in the C.S. Mott Children's Hospital Pediatric Emergency Department in the 2012–2013 academic year. The 4 metrics of schedule quality that were compared between the 2010–2011 and 2012–2013 academic years were the incidence of challenging shift transitions, the incidence of shifts following continuity clinics, the total shift inequity, and the night shift inequity. Results All scheduling rules were successfully incorporated. Average schedule creation time fell from 22 to 28 hours to 4 to 6 hours per month, and 3 of 4 metrics of schedule quality significantly improved. For the implementation year, the incidence of challenging shift transitions decreased from 83 to 14 (P < .01); the incidence of postclinic shifts decreased from 72 to 32 (P < .01); and the SD of night shifts dropped by 55.6% (P < .01). Conclusions This automated shift scheduling system improves the current manual scheduling process, reducing time spent and improving schedule quality. Embracing such automated tools can benefit residency programs with shift-based scheduling needs. PMID:26913102

  1. 75 FR 42831 - Proposed Collection; Comment Request for Form 1065, Schedule C, Schedule D, Schedule K-1...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-22

    ... Items), Schedule L (Balance Sheets per Books), Schedule M-1 (Reconciliation of Income (Loss) per Books.... (Schedule K-1), Balance Sheets per Books (Schedule L), Reconciliation of Income (Loss) per Books With Income...

  2. SO - SCHEDULE ORGANIZER COMPUTER PROGRAM

    NASA Technical Reports Server (NTRS)

    Collazo, F. F.

    1994-01-01

    The Schedule Organizer SO, Schedule Tracker, ST (COSMIC Program MSC-21526), and Report Generator, SRG (COSMIC Program MSC-21527), are programs that manipulate data base files in ways that are advantageous to scheduling applications. Originally designed for the Space Shuttle flight schedule, the program can be easily modified for other scheduling situations. Schedule Organizer provides a simple method for generating distribution lists. These distribution lists contain readers' names for each task schedule defined by the input files. Schedule Tracker provides an effective method for tracking tasks that are 'past due' and/or 'near term'. ST generates reports for each responsible staff member with one or more assigned tasks that fall within the two listed categories. This enables an engineering manager to monitor tasks assigned to staff by running ST on a weekly basis. ST only lists tasks on reports that have become past due or are scheduled for recent completion (near term). Schedule Report Generator provides a simple method for generating periodic schedule reports. SO contains the following primary menu that is displayed at the beginning of the program. The menu provides options: to write input files to an output distribution file, to change a schedule title field and/or distribution list field, to browse through the schedule and input names file for requested schedule numbers, to create an input names file and a schedule titles file, and to delete input schedule titles and associated names. SO provides a choice of two input files. One file holds twenty-five groups of up to twenty-five names for each group. The other file holds twenty-five records, each of which may hold a task schedule title. SO creates three output files. One holds the formatted list of schedule titles for printout. Another file holds the formatted distribution list for printout; there is one for each input names file schedule group. The third output file holds the last schedule title deleted by

  3. SO - SCHEDULE ORGANIZER COMPUTER PROGRAM

    NASA Technical Reports Server (NTRS)

    Collazo, F. F.

    1994-01-01

    The Schedule Organizer SO, Schedule Tracker, ST (COSMIC Program MSC-21526), and Report Generator, SRG (COSMIC Program MSC-21527), are programs that manipulate data base files in ways that are advantageous to scheduling applications. Originally designed for the Space Shuttle flight schedule, the program can be easily modified for other scheduling situations. Schedule Organizer provides a simple method for generating distribution lists. These distribution lists contain readers' names for each task schedule defined by the input files. Schedule Tracker provides an effective method for tracking tasks that are 'past due' and/or 'near term'. ST generates reports for each responsible staff member with one or more assigned tasks that fall within the two listed categories. This enables an engineering manager to monitor tasks assigned to staff by running ST on a weekly basis. ST only lists tasks on reports that have become past due or are scheduled for recent completion (near term). Schedule Report Generator provides a simple method for generating periodic schedule reports. SO contains the following primary menu that is displayed at the beginning of the program. The menu provides options: to write input files to an output distribution file, to change a schedule title field and/or distribution list field, to browse through the schedule and input names file for requested schedule numbers, to create an input names file and a schedule titles file, and to delete input schedule titles and associated names. SO provides a choice of two input files. One file holds twenty-five groups of up to twenty-five names for each group. The other file holds twenty-five records, each of which may hold a task schedule title. SO creates three output files. One holds the formatted list of schedule titles for printout. Another file holds the formatted distribution list for printout; there is one for each input names file schedule group. The third output file holds the last schedule title deleted by

  4. The impact of system level factors on treatment timeliness: utilizing the Toyota Production System to implement direct intake scheduling in a semi-rural community mental health clinic.

    PubMed

    Weaver, Addie; Greeno, Catherine G; Goughler, Donald H; Yarzebinski, Kathleen; Zimmerman, Tina; Anderson, Carol

    2013-07-01

    This study examined the effect of using the Toyota Production System (TPS) to change intake procedures on treatment timeliness within a semi-rural community mental health clinic. One hundred randomly selected cases opened the year before the change and 100 randomly selected cases opened the year after the change were reviewed. An analysis of covariance demonstrated that changing intake procedures significantly decreased the number of days consumers waited for appointments (F(1,160) = 4.9; p = .03) from an average of 11 to 8 days. The pattern of difference on treatment timeliness was significantly different between adult and child programs (F(1,160) = 4.2; p = .04), with children waiting an average of 4 days longer than adults for appointments. Findings suggest that small system level changes may elicit important changes and that TPS offers a valuable model to improve processes within community mental health settings. Results also indicate that different factors drive adult and children's treatment timeliness.

  5. Parallel job-scheduling algorithms

    SciTech Connect

    Rodger, S.H.

    1989-01-01

    In this thesis, we consider solving job scheduling problems on the CREW PRAM model. We show how to adapt Cole's pipeline merge technique to yield several efficient parallel algorithms for a number of job scheduling problems and one optimal parallel algorithm for the following job scheduling problem: Given a set of n jobs defined by release times, deadlines and processing times, find a schedule that minimizes the maximum lateness of the jobs and allows preemption when the jobs are scheduled to run on one machine. In addition, we present the first NC algorithm for the following job scheduling problem: Given a set of n jobs defined by release times, deadlines and unit processing times, determine if there is a schedule of jobs on one machine, and calculate the schedule if it exists. We identify the notion of a canonical schedule, which is the type of schedule our algorithm computes if there is a schedule. Our algorithm runs in O((log n){sup 2}) time and uses O(n{sup 2}k{sup 2}) processors, where k is the minimum number of distinct offsets of release times or deadlines.

  6. Performance Improvement in Behavioral Health Care: Collateral Effects of Planned Treatment Integrity Observations as an Applied Example of Schedule-Induced Responding

    ERIC Educational Resources Information Center

    Reed, Derek D.; Fienup, Daniel M.; Luiselli, James K.; Pace, Gary M.

    2010-01-01

    With rising interest in the role of treatment integrity on student outcomes, research has primarily focused on isolating the techniques and procedures necessary to improve staff's acquisition and maintenance of adequate levels of integrity. Despite increasing numbers of publications on this topic, there has been little discussion of the variables…

  7. Classical Hodgkin lymphoma-type PTLD after solid organ transplantation in children: a report on 17 patients treated according to subsequent GPOH-HD treatment schedules.

    PubMed

    Kampers, Johanna; Orjuela-Grimm, Manuela; Schober, Tilmann; Schulz, Thomas F; Stiefel, Martina; Klein, Christoph; Körholz, Dieter; Mauz-Körholz, Christine; Kreipe, Hans; Beier, Rita; Maecker-Kolhoff, Britta

    2017-03-01

    Post-transplant lymphoproliferative disease (PTLD) is a severe complication after solid organ transplantation (SOT). Classical Hodgkin lymphoma-type (HL-) PTLD is a rare subtype, and systematic data on treatment and prognosis are lacking. We report on 17 pediatric patients with classical HL-PTLD. HL-PTLD developed late at a median of 8.1 years after SOT. It was commonly EBV-positive (16/17) and expressed both CD30 (all tumors) and CD20 (8/17 tumors). Patients were treated with chemotherapy +/- involved field radiotherapy (IF-RT) according to the respective GPOH-HD protocol tailored by stage and LDH. Overall survival at 2 and 5 years was 86% with 81% of patients surviving event-free. Six patients had additional rituximab treatment; in two it was given as upfront monotherapy and in four was given concurrently with their chemotherapy. Rituximab monotherapy did not lead to long-term remission. In conclusion, treatment of HL-PTLD with classical HL chemotherapy is effective and tolerable. New treatment modalities such as CD30-targeted or EBV-specific agents may diminish toxicity.

  8. Performance Improvement in Behavioral Health Care: Collateral Effects of Planned Treatment Integrity Observations as an Applied Example of Schedule-Induced Responding

    ERIC Educational Resources Information Center

    Reed, Derek D.; Fienup, Daniel M.; Luiselli, James K.; Pace, Gary M.

    2010-01-01

    With rising interest in the role of treatment integrity on student outcomes, research has primarily focused on isolating the techniques and procedures necessary to improve staff's acquisition and maintenance of adequate levels of integrity. Despite increasing numbers of publications on this topic, there has been little discussion of the variables…

  9. Comparison of three rapamycin dosing schedules in A/J Tsc2+/- mice and improved survival with angiogenesis inhibitor or asparaginase treatment in mice with subcutaneous tuberous sclerosis related tumors

    PubMed Central

    2010-01-01

    Background Tuberous Sclerosis Complex (TSC) is an autosomal dominant tumor disorder characterized by the growth of hamartomas in various organs including the kidney, brain, skin, lungs, and heart. Rapamycin has been shown to reduce the size of kidney angiomyolipomas associated with TSC; however, tumor regression is incomplete and kidney angiomyolipomas regrow after cessation of treatment. Mouse models of TSC2 related tumors are useful for evaluating new approaches to drug therapy for TSC. Methods In cohorts of Tsc2+/- mice, we compared kidney cystadenoma severity in A/J and C57BL/6 mouse strains at both 9 and 12 months of age. We also investigated age related kidney tumor progression and compared three different rapamycin treatment schedules in cohorts of A/J Tsc2+/- mice. In addition, we used nude mice bearing Tsc2-/- subcutaneous tumors to evaluate the therapeutic utility of sunitinib, bevacizumab, vincristine, and asparaginase. Results TSC related kidney disease severity is 5-10 fold higher in A/J Tsc2+/- mice compared with C57BL/6 Tsc2+/- mice. Similar to kidney angiomyolipomas associated with TSC, the severity of kidney cystadenomas increases with age in A/J Tsc2+/- mice. When rapamycin dosing schedules were compared in A/J Tsc2+/- cohorts, we observed a 66% reduction in kidney tumor burden in mice treated daily for 4 weeks, an 82% reduction in mice treated daily for 4 weeks followed by weekly for 8 weeks, and an 81% reduction in mice treated weekly for 12 weeks. In the Tsc2-/- subcutaneous tumor mouse model, vincristine is not effective, but angiogenesis inhibitors (sunitinib and bevacizumab) and asparaginase are effective as single agents. However, these drugs are not as effective as rapamycin in that they increased median survival only by 24-27%, while rapamycin increased median survival by 173%. Conclusions Our results indicate that the A/J Tsc2+/- mouse model is an improved, higher through-put mouse model for future TSC preclinical studies. The rapamycin

  10. Automated Platform Management System Scheduling

    NASA Technical Reports Server (NTRS)

    Hull, Larry G.

    1990-01-01

    The Platform Management System was established to coordinate the operation of platform systems and instruments. The management functions are split between ground and space components. Since platforms are to be out of contact with the ground more than the manned base, the on-board functions are required to be more autonomous than those of the manned base. Under this concept, automated replanning and rescheduling, including on-board real-time schedule maintenance and schedule repair, are required to effectively and efficiently meet Space Station Freedom mission goals. In a FY88 study, we developed several promising alternatives for automated platform planning and scheduling. We recommended both a specific alternative and a phased approach to automated platform resource scheduling. Our recommended alternative was based upon use of exactly the same scheduling engine in both ground and space components of the platform management system. Our phased approach recommendation was based upon evolutionary development of the platform. In the past year, we developed platform scheduler requirements and implemented a rapid prototype of a baseline platform scheduler. Presently we are rehosting this platform scheduler rapid prototype and integrating the scheduler prototype into two Goddard Space Flight Center testbeds, as the ground scheduler in the Scheduling Concepts, Architectures, and Networks Testbed and as the on-board scheduler in the Platform Management System Testbed. Using these testbeds, we will investigate rescheduling issues, evaluate operational performance and enhance the platform scheduler prototype to demonstrate our evolutionary approach to automated platform scheduling. The work described in this paper was performed prior to Space Station Freedom rephasing, transfer of platform responsibility to Code E, and other recently discussed changes. We neither speculate on these changes nor attempt to predict the impact of the final decisions. As a consequence some of our

  11. The Impact of System Level Factors on Treatment Timeliness: Utilizing the Toyota Production System to Implement Direct Intake Scheduling in a Semi-Rural Community Mental Health Clinic

    PubMed Central

    Weaver, A.; Greeno, C.G.; Goughler, D.H.; Yarzebinski, K.; Zimmerman, T.; Anderson, C.

    2013-01-01

    This study examined the effect of using the Toyota Production System (TPS) to change intake procedures on treatment timeliness within a semi-rural community mental health clinic. One hundred randomly selected cases opened the year before the change and one hundred randomly selected cases opened the year after the change were reviewed. An analysis of covariance (ANCOVA) demonstrated that changing intake procedures significantly decreased the number of days consumers waited for appointments (F(1,160)=4.9; p=.03) from an average of 11 days to 8 days. The pattern of difference on treatment timeliness was significantly different between adult and child programs (F(1,160)=4.2; p=.04), with children waiting an average of 4 days longer than adults for appointments. Findings suggest that small system level changes may elicit important changes and that TPS offers a valuable model to improve processes within community mental health settings. Results also indicate that different factors drive adult and children’s treatment timeliness. PMID:23576137

  12. 2007 Wholesale Power Rate Schedules : 2007 General Rate Schedule Provisions.

    SciTech Connect

    United States. Bonneville Power Administration.

    2006-11-01

    This schedule is available for the contract purchase of Firm Power to be used within the Pacific Northwest (PNW). Priority Firm (PF) Power may be purchased by public bodies, cooperatives, and Federal agencies for resale to ultimate consumers, for direct consumption, and for Construction, Test and Start-Up, and Station Service. Rates in this schedule are in effect beginning October 1, 2006, and apply to purchases under requirements Firm Power sales contracts for a three-year period. The Slice Product is only available for public bodies and cooperatives who have signed Slice contracts for the FY 2002-2011 period. Utilities participating in the Residential Exchange Program (REP) under Section 5(c) of the Northwest Power Act may purchase Priority Firm Power pursuant to the Residential Exchange Program. Rates under contracts that contain charges that escalate based on BPA's Priority Firm Power rates shall be based on the three-year rates listed in this rate schedule in addition to applicable transmission charges. This rate schedule supersedes the PF-02 rate schedule, which went into effect October 1, 2001. Sales under the PF-07 rate schedule are subject to BPA's 2007 General Rate Schedule Provisions (2007 GRSPs). Products available under this rate schedule are defined in the 2007 GRSPs. For sales under this rate schedule, bills shall be rendered and payments due pursuant to BPA's 2007 GRSPs and billing process.

  13. DTS: Building custom, intelligent schedulers

    NASA Technical Reports Server (NTRS)

    Hansson, Othar; Mayer, Andrew

    1994-01-01

    DTS is a decision-theoretic scheduler, built on top of a flexible toolkit -- this paper focuses on how the toolkit might be reused in future NASA mission schedulers. The toolkit includes a user-customizable scheduling interface, and a 'Just-For-You' optimization engine. The customizable interface is built on two metaphors: objects and dynamic graphs. Objects help to structure problem specifications and related data, while dynamic graphs simplify the specification of graphical schedule editors (such as Gantt charts). The interface can be used with any 'back-end' scheduler, through dynamically-loaded code, interprocess communication, or a shared database. The 'Just-For-You' optimization engine includes user-specific utility functions, automatically compiled heuristic evaluations, and a postprocessing facility for enforcing scheduling policies. The optimization engine is based on BPS, the Bayesian Problem-Solver (1,2), which introduced a similar approach to solving single-agent and adversarial graph search problems.

  14. Cetuximab in the first-line treatment of K-ras wild-type metastatic colorectal cancer: the choice and schedule of fluoropyrimidine matters.

    PubMed

    Ku, Geoffrey Y; Haaland, Benjamin A; de Lima Lopes, Gilberto

    2012-08-01

    Cetuximab, a monoclonal antibody against the epidermal growth factor receptor, inconsistently improves response rates (RR), progression-free survival (PFS) and overall survival (OS) in the first-line treatment of advanced colorectal cancer patients with K-ras wild-type (WT) tumors. We performed a meta-analysis of four trials where K-ras WT Pts received a fluoropyrimidine (infusional vs. bolus 5-fluorouracil (5-FU) vs. capecitabine) and oxaliplatin or irinotecan with and without cetuximab (CRYSTAL, OPUS, COIN and NORDIC VII trials) and two trials, where K-ras WT and mutant patients received cetuximab and a fluoropyrimidine (capecitabine in a German AIO study and infusional 5-FU in the CECOG study) with oxaliplatin versus irinotecan. We sought to determine whether the choice of fluoropyrimidine or of oxaliplatin versus irinotecan affects the response to cetuximab. Meta-analysis was performed in the context of a mixed effects model with a random effect for each study. Only patients treated with infusional 5-FU-based chemotherapy derived benefit from cetuximab. Relative to infusional 5-FU, patients treated with capecitabine/bolus 5-FU-based doublet chemotherapy had a 42 % (95 % CI 21-58 %; p < 0.001) decrease in response probability and a 52 % (95 % CI 20-93 %; p < 0.001) and 33 % (95 % CI 7-65 %; p = 0.012) increase, respectively, in risk of progression and death. The choice of oxaliplatin or irinotecan did not affect benefit from cetuximab. The lack of benefit for cetuximab with capecitabine/bolus 5-FU regimens is unexpected. Cetuximab should only be used with infusional 5-FU regimens in the first-line treatment of K-ras WT colorectal cancer patients. Further study is urgently needed to elucidate the basis of this observation.

  15. ST - SCHEDULE TRACKER COMPUTER PROGRAM

    NASA Technical Reports Server (NTRS)

    Collazo, F. F.

    1994-01-01

    The Schedule Organizer, SO (COSMIC Program MSC-21525), Schedule Tracker, ST, and Schedule Report Generator, SRG (COSMIC Program MSC-21527), are programs that manipulate data base files in ways that are advantageous to scheduling applications. Originally designed for the Space Shuttle flight schedule, the program can be easily modified for other scheduling situations. Schedule Organizer provides a simple method for generating distribution lists. These distribution lists contain readers' names for each task schedule defined by the input files. Schedule Tracker provides an effective method for tracking tasks that are 'past due' and/or 'near term'. ST generates reports for each responsible staff member with one or more assigned tasks that fall within the two listed categories. This enables an engineering manager to monitor tasks assigned to staff by running ST on a weekly basis. ST only lists tasks on reports that have become past due or are scheduled for recent completion (near term). Schedule Report Generator provides a simple method for generating periodic schedule reports. ST and SRG use the same data base file as input. The common data base file has a maximum number of 400 entries. The time span of all three programs is nineteen months. Both of these maximum numbers can be modified by the user. ST requires the VMS Operating System on DEC VAX and was written in PL/1 and DEC Command Language (DCL). The program requires a memory of 233KB. ST can be purchased separately or in a package (COSMIC Program COS-10021) containing SO, ST, and SRG. ST was developed in 1985.

  16. Effective Scheduling Using Sacred Time.

    PubMed

    Baum, Neil

    2016-01-01

    Doctors need to become more efficient in order to become more productive. One of the best ways to enhance efficiency is effective scheduling. Every practice has several urgencies or emergencies every day that have to be worked into the schedule, and these few additional patients can wreak havoc with the schedule. This article will discuss.how to use "sacred time" in order to enhance efficiency in the practice.

  17. ST - SCHEDULE TRACKER COMPUTER PROGRAM

    NASA Technical Reports Server (NTRS)

    Collazo, F. F.

    1994-01-01

    The Schedule Organizer, SO (COSMIC Program MSC-21525), Schedule Tracker, ST, and Schedule Report Generator, SRG (COSMIC Program MSC-21527), are programs that manipulate data base files in ways that are advantageous to scheduling applications. Originally designed for the Space Shuttle flight schedule, the program can be easily modified for other scheduling situations. Schedule Organizer provides a simple method for generating distribution lists. These distribution lists contain readers' names for each task schedule defined by the input files. Schedule Tracker provides an effective method for tracking tasks that are 'past due' and/or 'near term'. ST generates reports for each responsible staff member with one or more assigned tasks that fall within the two listed categories. This enables an engineering manager to monitor tasks assigned to staff by running ST on a weekly basis. ST only lists tasks on reports that have become past due or are scheduled for recent completion (near term). Schedule Report Generator provides a simple method for generating periodic schedule reports. ST and SRG use the same data base file as input. The common data base file has a maximum number of 400 entries. The time span of all three programs is nineteen months. Both of these maximum numbers can be modified by the user. ST requires the VMS Operating System on DEC VAX and was written in PL/1 and DEC Command Language (DCL). The program requires a memory of 233KB. ST can be purchased separately or in a package (COSMIC Program COS-10021) containing SO, ST, and SRG. ST was developed in 1985.

  18. COMPASS: An Ada based scheduler

    NASA Technical Reports Server (NTRS)

    Mcmahon, Mary Beth; Culbert, Chris

    1992-01-01

    COMPASS is a generic scheduling system developed by McDonnell Douglas and funded by the Software Technology Branch of NASA Johnson Space Center. The motivation behind COMPASS is to illustrate scheduling technology and provide a basis from which custom scheduling systems can be built. COMPASS was written in Ada to promote readability and to conform to DOD standards. COMPASS has some unique characteristics that distinguishes it from commercial products. This paper discusses these characteristics and uses them to illustrate some differences between scheduling tools.

  19. 1993 Wholesale Power and Transmission Rate Schedules.

    SciTech Connect

    US Bonneville Power Administration

    1993-10-01

    Bonneville Power Administration 1993 Wholesale Power Rate Schedules and General Rate Schedule Provisions and 1993 Transmission Rate Schedules and General Transmission Rate Schedule Provisions, contained herein, were approved on an interim basis effective October 1, 1993. These rate schedules and provisions were approved by the Federal Energy Commission, United States Department of Energy, in September, 1993. These rate schedules and provisions supersede the Administration`s Wholesale Power Rate Schedules and General Rate Schedule Provisions and Transmission Rate Schedules and General Transmission Rate Schedule Provisions effective October 1, 1991.

  20. Dynamics in scheduled networks

    NASA Astrophysics Data System (ADS)

    Zanin, Massimiliano; Lacasa, Lucas; Cea, Miguel

    2009-06-01

    When studying real or virtual systems through complex networks theories, usually time restrictions are neglected, and a static structure is defined to characterize which node is connected to which other. However, this approach is oversimplified, as real networks are indeed dynamically modified by external mechanisms. In order to bridge the gap, in this work we present a scheduled network formalism, which takes into account such dynamical modifications by including generic time restrictions in the structure of an extended adjacency matrix. We present some of its properties and apply this formalism to the specific case of the air transportation network in order to analyze its efficiency. Real data are used at this point. We finally discuss on the applicability of this formalism to other complex systems.

  1. Optimum connection management scheduling

    NASA Astrophysics Data System (ADS)

    Kadar, Ivan

    2000-08-01

    Connection Management plays a key role in both distributed 'local' network-centric and 'globally' connected info- centric systems. The role of Connection Management is to provide seamless demand-based sharing of the information products. For optimum distributed information fusion performance, these systems must minimize communications delays and maximize message throughput, and at the same time take into account relative-sensors-targets geometrical constraints and data pedigree. In order to achieve overall distributed 'network' effectiveness, these systems must be adaptive, and be able to distribute data s needed in real- time. A system concept will be described which provides optimum capacity-based information scheduling. A specific example, based on a satellite channel, is used to illustrate simulated performance results and their effects on fusion systems performance.

  2. Visually Exploring Transportation Schedules.

    PubMed

    Palomo, Cesar; Guo, Zhan; Silva, Cláudio T; Freire, Juliana

    2016-01-01

    Public transportation schedules are designed by agencies to optimize service quality under multiple constraints. However, real service usually deviates from the plan. Therefore, transportation analysts need to identify, compare and explain both eventual and systemic performance issues that must be addressed so that better timetables can be created. The purely statistical tools commonly used by analysts pose many difficulties due to the large number of attributes at trip- and station-level for planned and real service. Also challenging is the need for models at multiple scales to search for patterns at different times and stations, since analysts do not know exactly where or when relevant patterns might emerge and need to compute statistical summaries for multiple attributes at different granularities. To aid in this analysis, we worked in close collaboration with a transportation expert to design TR-EX, a visual exploration tool developed to identify, inspect and compare spatio-temporal patterns for planned and real transportation service. TR-EX combines two new visual encodings inspired by Marey's Train Schedule: Trips Explorer for trip-level analysis of frequency, deviation and speed; and Stops Explorer for station-level study of delay, wait time, reliability and performance deficiencies such as bunching. To tackle overplotting and to provide a robust representation for a large numbers of trips and stops at multiple scales, the system supports variable kernel bandwidths to achieve the level of detail required by users for different tasks. We justify our design decisions based on specific analysis needs of transportation analysts. We provide anecdotal evidence of the efficacy of TR-EX through a series of case studies that explore NYC subway service, which illustrate how TR-EX can be used to confirm hypotheses and derive new insights through visual exploration.

  3. Schedules of Controlled Substances: Temporary Placement of 4-Fluoroisobutyryl Fentanyl into Schedule I. Temporary scheduling order.

    PubMed

    2017-05-03

    The Administrator of the Drug Enforcement Administration is issuing this temporary scheduling order to schedule the synthetic opioid, N-(4-fluorophenyl)-N-(1-phenethylpiperidin-4-yl)isobutyramide (4-fluoroisobutyryl fentanyl or para-fluoroisobutyryl fentanyl), and its isomers, esters, ethers, salts and salts of isomers, esters, and ethers, into schedule I pursuant to the temporary scheduling provisions of the Controlled Substances Act. This action is based on a finding by the Administrator that the placement of 4-fluoroisobutyryl fentanyl into schedule I of the Controlled Substances Act is necessary to avoid an imminent hazard to the public safety. As a result of this order, the regulatory controls and administrative, civil, and criminal sanctions applicable to schedule I controlled substances will be imposed on persons who handle (manufacture, distribute, reverse distribute, import, export, engage in research, conduct instructional activities or chemical analysis, or possess), or propose to handle, 4-fluoroisobutyryl fentanyl.

  4. Prospective randomized study of various irradiation doses and fractionation schedules in the treatment of inoperable non-oat-cell carcinoma of the lung

    SciTech Connect

    Perez, C.A.; Stanley, K.; Rubin, P.; Kramer, S.; Brady, L.; Perez-Tamayo, R.; Brown, G.S.; Concannon, J.; Rotman, M.; Seydel, H.G.

    1980-06-01

    Analysis is presented of a prospective randomized study involving 365 patients with histologically proven unresectable non-oat-cell carcinoma of the lung treated with deffinitive radiotherapy. The patients were radomized to one of four treatment regimens: 4000 rad split course, or 4000, 5000, or 6000-rad continuous courses in five fractions per week. Ninety to 100 patients were accessioned to each group. The one-year survival rate is 50% and the two-year survival rate, 25%. The patients treated with the split course have the lowest survival rate in comparison with the other groups. The complete and partial local regression of tumor was 49% in patients treated with 4000 rad and 55% in the groups treated with 5000 and 6000 rad. For patients who achieved complete regression of the tumor following irradiation, the two-year survival rate is 40%, in contrast to 20% for those with partial regression, and no survivors among the patients with stable or progressive disease. The incidence of intrathoracic recurrence was 33% for patients treated with 6000 rad, 39% for those receiving 5000 rad, and 44 to 49% for those treated with a 4000-rad split or continuous course. At present, the data stongly suggest that patients treated with 5000 or 6000 rad have a better response, tumor control, and survival rate than those receiving lower doses. Patients with high performance status or with tumors in earlier stages have a two-year survival rate of approx. 40%, in comparison with 20% for other patients. The various irradiation regimens have been well tolerated, with complications being slightly higher in the 4000-rad split course group and in the 6000-rad continuous course group. The most frequent complications have been pneumonitis, pulmonary fibrosis, and dyspagia due to transient esophagitis. Further investigation will be necessary before the optimal management of patients with bronchogenic carcinoma by irradiation is established.

  5. Minimizing metastatic risk in radiotherapy fractionation schedules

    NASA Astrophysics Data System (ADS)

    Badri, Hamidreza; Ramakrishnan, Jagdish; Leder, Kevin

    2015-11-01

    Metastasis is the process by which cells from a primary tumor disperse and form new tumors at distant anatomical locations. The treatment and prevention of metastatic cancer remains an extremely challenging problem. This work introduces a novel biologically motivated objective function to the radiation optimization community that takes into account metastatic risk instead of the status of the primary tumor. In this work, we consider the problem of developing fractionated irradiation schedules that minimize production of metastatic cancer cells while keeping normal tissue damage below an acceptable level. A dynamic programming framework is utilized to determine the optimal fractionation scheme. We evaluated our approach on a breast cancer case using the heart and the lung as organs-at-risk (OAR). For small tumor α /β values, hypo-fractionated schedules were optimal, which is consistent with standard models. However, for relatively larger α /β values, we found the type of schedule depended on various parameters such as the time when metastatic risk was evaluated, the α /β values of the OARs, and the normal tissue sparing factors. Interestingly, in contrast to standard models, hypo-fractionated and semi-hypo-fractionated schedules (large initial doses with doses tapering off with time) were suggested even with large tumor α/β values. Numerical results indicate the potential for significant reduction in metastatic risk.

  6. Scheduled Intermittent Screening with Rapid Diagnostic Tests and Treatment with Dihydroartemisinin-Piperaquine versus Intermittent Preventive Therapy with Sulfadoxine-Pyrimethamine for Malaria in Pregnancy in Malawi: An Open-Label Randomized Controlled Trial

    PubMed Central

    Madanitsa, Mwayiwawo; Kalilani, Linda; Mwapasa, Victor; van Eijk, Anna M.; Khairallah, Carole; Ali, Doreen; Pace, Cheryl; Smedley, James; Thwai, Kyaw-Lay; Levitt, Brandt; Kang’ombe, Arthur; Faragher, Brian; Taylor, Steve M.; Meshnick, Steve; ter Kuile, Feiko O.

    2016-01-01

    Background In Africa, most plasmodium infections during pregnancy remain asymptomatic, yet are associated with maternal anemia and low birthweight. WHO recommends intermittent preventive therapy in pregnancy with sulfadoxine-pyrimethamine (IPTp-SP). However, sulfadoxine-pyrimethamine (SP) efficacy is threatened by high-level parasite resistance. We conducted a trial to evaluate the efficacy and safety of scheduled intermittent screening with malaria rapid diagnostic tests (RDTs) and treatment of RDT-positive women with dihydroartemisinin-piperaquine (DP) as an alternative strategy to IPTp-SP. Methods and Findings This was an open-label, two-arm individually randomized superiority trial among HIV-seronegative women at three sites in Malawi with high SP resistance. The intervention consisted of three or four scheduled visits in the second and third trimester, 4 to 6 wk apart. Women in the IPTp-SP arm received SP at each visit. Women in the intermittent screening and treatment in pregnancy with DP (ISTp-DP) arm were screened for malaria at every visit and treated with DP if RDT-positive. The primary outcomes were adverse live birth outcome (composite of small for gestational age, low birthweight [<2,500 g], or preterm birth [<37 wk]) in paucigravidae (first or second pregnancy) and maternal or placental plasmodium infection at delivery in multigravidae (third pregnancy or higher). Analysis was by intention to treat. Between 21 July 2011 and 18 March 2013, 1,873 women were recruited (1,155 paucigravidae and 718 multigravidae). The prevalence of adverse live birth outcome was similar in the ISTp-DP (29.9%) and IPTp-SP (28.8%) arms (risk difference = 1.08% [95% CI −3.25% to 5.41%]; all women: relative risk [RR] = 1.04 [95% CI 0.90–1.20], p = 0.625; paucigravidae: RR = 1.10 [95% CI 0.92–1.31], p = 0.282; multigravidae: RR = 0.92 [95% CI 0.71–1.20], p = 0.543). The prevalence of malaria at delivery was higher in the ISTp-DP arm (48.7% versus 40.8%; risk difference

  7. Scheduled Intermittent Screening with Rapid Diagnostic Tests and Treatment with Dihydroartemisinin-Piperaquine versus Intermittent Preventive Therapy with Sulfadoxine-Pyrimethamine for Malaria in Pregnancy in Malawi: An Open-Label Randomized Controlled Trial.

    PubMed

    Madanitsa, Mwayiwawo; Kalilani, Linda; Mwapasa, Victor; van Eijk, Anna M; Khairallah, Carole; Ali, Doreen; Pace, Cheryl; Smedley, James; Thwai, Kyaw-Lay; Levitt, Brandt; Wang, Duolao; Kang'ombe, Arthur; Faragher, Brian; Taylor, Steve M; Meshnick, Steve; Ter Kuile, Feiko O

    2016-09-01

    In Africa, most plasmodium infections during pregnancy remain asymptomatic, yet are associated with maternal anemia and low birthweight. WHO recommends intermittent preventive therapy in pregnancy with sulfadoxine-pyrimethamine (IPTp-SP). However, sulfadoxine-pyrimethamine (SP) efficacy is threatened by high-level parasite resistance. We conducted a trial to evaluate the efficacy and safety of scheduled intermittent screening with malaria rapid diagnostic tests (RDTs) and treatment of RDT-positive women with dihydroartemisinin-piperaquine (DP) as an alternative strategy to IPTp-SP. This was an open-label, two-arm individually randomized superiority trial among HIV-seronegative women at three sites in Malawi with high SP resistance. The intervention consisted of three or four scheduled visits in the second and third trimester, 4 to 6 wk apart. Women in the IPTp-SP arm received SP at each visit. Women in the intermittent screening and treatment in pregnancy with DP (ISTp-DP) arm were screened for malaria at every visit and treated with DP if RDT-positive. The primary outcomes were adverse live birth outcome (composite of small for gestational age, low birthweight [<2,500 g], or preterm birth [<37 wk]) in paucigravidae (first or second pregnancy) and maternal or placental plasmodium infection at delivery in multigravidae (third pregnancy or higher). Analysis was by intention to treat. Between 21 July 2011 and 18 March 2013, 1,873 women were recruited (1,155 paucigravidae and 718 multigravidae). The prevalence of adverse live birth outcome was similar in the ISTp-DP (29.9%) and IPTp-SP (28.8%) arms (risk difference = 1.08% [95% CI -3.25% to 5.41%]; all women: relative risk [RR] = 1.04 [95% CI 0.90-1.20], p = 0.625; paucigravidae: RR = 1.10 [95% CI 0.92-1.31], p = 0.282; multigravidae: RR = 0.92 [95% CI 0.71-1.20], p = 0.543). The prevalence of malaria at delivery was higher in the ISTp-DP arm (48.7% versus 40.8%; risk difference = 7.85%, [95% CI 3.07%-12.63%]; all

  8. Job scheduling on a hypercube

    SciTech Connect

    Zhu, Yahui.

    1990-01-01

    The author studies the scheduling of independent jobs on hypercube multiprocessors. He assumes that the hypercube system supports space-sharing for multiprogramming, i.e., a hypercube is partitioned into subcubes and each job is assigned to a dedicated subcube and many jobs can be running simultaneously without interfering with each other. Then the problem of how to schedule a set of jobs so that they can be finished as early as possible becomes important. He investigates two kinds of scheduling algorithms for the problem. The first one is nonpreemptive scheduling, i.e., no job is allowed to be interrupted during its execution. In this case, the problem is NP-Complete. He proposes an approximation algorithm called LDF, which generates a schedule with a finish time less than twice that of an optimal schedule. Compared with the earlier proposed algorithm, his algorithm is simpler and has almost the same performance. More importantly, his LDF algorithm can achieve this performance without knowing the job processing times, which may be hard to obtain in practice. Also he proves a lower bound result which implies that it is unlikely to find simple heuristic algorithms that can perform much better than the existing algorithms including LDF. The second kind is preemptive scheduling, i.e., a job can be preempted during its execution and rescheduled later. He develops a feasibility algorithm that runs in O (n log n) time and generates a schedule with at most min{l brace}n-2, 2{sup m}-1{r brace} preemptions. It can generate a feasible schedule for the given job set if there exists one. This improvement is important because many scheduling algorithms depend on a feasibility algorithm as a building block. Furthermore, based on an advanced search technique, he presents an algorithm that can find the optimal schedule in O(n{sup 2} log {sup 2}n) time.

  9. Constraint-Based Scheduling System

    NASA Technical Reports Server (NTRS)

    Zweben, Monte; Eskey, Megan; Stock, Todd; Taylor, Will; Kanefsky, Bob; Drascher, Ellen; Deale, Michael; Daun, Brian; Davis, Gene

    1995-01-01

    Report describes continuing development of software for constraint-based scheduling system implemented eventually on massively parallel computer. Based on machine learning as means of improving scheduling. Designed to learn when to change search strategy by analyzing search progress and learning general conditions under which resource bottleneck occurs.

  10. Block Schedule: Breaking the Barriers.

    ERIC Educational Resources Information Center

    West, Mike

    As of 1996, Chaparral High School in Las Vegas, Nevada, was in the fourth year of a radical restructuring effort. The school changed from a 6-period day, composed of 51-minute periods, to an alternating day schedule, composed of 3 102-minute periods per day. This report describes how the school developed and implemented the new schedule. Faculty…

  11. Modeling the Cray memory scheduler

    SciTech Connect

    Wickham, K.L.; Litteer, G.L.

    1992-04-01

    This report documents the results of a project to evaluate low cost modeling and simulation tools when applied to modeling the Cray memory scheduler. The specific tool used is described and the basics of the memory scheduler are covered. Results of simulations using the model are discussed and a favorable recommendation is made to make more use of this inexpensive technology.

  12. Modeling the Cray memory scheduler

    SciTech Connect

    Wickham, K.L.; Litteer, G.L.

    1992-04-01

    This report documents the results of a project to evaluate low cost modeling and simulation tools when applied to modeling the Cray memory scheduler. The specific tool used is described and the basics of the memory scheduler are covered. Results of simulations using the model are discussed and a favorable recommendation is made to make more use of this inexpensive technology.

  13. Scheduling Guide for Program Managers

    DTIC Science & Technology

    2001-10-01

    and val- leys are evened out without scheduling more work than nine people can do. In this ex- ample, this rearrangement can be accom- plished quickly...full advantage of event- driven scheduling. Additional information on the development of IMSs can be found in various sections of the Defense

  14. Interactive computer aided shift scheduling.

    PubMed

    Gaertner, J

    2001-12-01

    This paper starts with a discussion of computer aided shift scheduling. After a brief review of earlier approaches, two conceptualizations of this field are introduced: First, shift scheduling as a field that ranges from extremely stable rosters at one pole to rather market-like approaches on the other pole. Unfortunately, already small alterations of a scheduling problem (e.g., the number of groups, the number of shifts) may call for rather different approaches and tools. Second, their environment shapes scheduling problems and scheduling has to be done within idiosyncratic organizational settings. This calls for the amalgamation of scheduling with other tasks (e.g., accounting) and for reflections whether better solutions might become possible by changes in the problem definition (e.g., other service levels, organizational changes). Therefore shift scheduling should be understood as a highly connected problem. Building upon these two conceptualizations, a few examples of software that ease scheduling in some areas of this field are given and future research questions are outlined.

  15. Nontraditional work schedules for pharmacists.

    PubMed

    Mahaney, Lynnae; Sanborn, Michael; Alexander, Emily

    2008-11-15

    Nontraditional work schedules for pharmacists at three institutions are described. The demand for pharmacists and health care in general continues to increase, yet significant material changes are occurring in the pharmacy work force. These changing demographics, coupled with historical vacancy rates and turnover trends for pharmacy staff, require an increased emphasis on workplace changes that can improve staff recruitment and retention. At William S. Middleton Memorial Veterans Affairs Hospital in Madison, Wisconsin, creative pharmacist work schedules and roles are now mainstays to the recruitment and retention of staff. The major challenge that such scheduling presents is the 8 hours needed to prepare a six-week schedule. Baylor Medical Center at Grapevine in Dallas, Texas, has a total of 45 pharmacy employees, and slightly less than half of the 24.5 full-time-equivalent staff work full-time, with most preferring to work one, two, or three days per week. As long as the coverage needs of the facility are met, Envision Telepharmacy in Alpine, Texas, allows almost any scheduling arrangement preferred by individual pharmacists or the pharmacist group covering the facility. Staffing involves a great variety of shift lengths and intervals, with shifts ranging from 2 to 10 hours. Pharmacy leaders must be increasingly aware of opportunities to provide staff with unique scheduling and operational enhancements that can provide for a better work-life balance. Compressed workweeks, job-sharing, and team scheduling were the most common types of alternative work schedules implemented at three different institutions.

  16. The Effectiveness of Block Scheduling.

    ERIC Educational Resources Information Center

    Creamean, Sharon Lightle; Horvath, Robert Jeffery

    This report describes a program for the exploration of block scheduling. The targeted population consists of high school students in a growing, middle-class community, located in a suburban setting of a large mid-western city. The historical background of block scheduling is documented through data gathered using attendance reports, student…

  17. Scheduling Software for Complex Scenarios

    NASA Technical Reports Server (NTRS)

    2006-01-01

    Preparing a vehicle and its payload for a single launch is a complex process that involves thousands of operations. Because the equipment and facilities required to carry out these operations are extremely expensive and limited in number, optimal assignment and efficient use are critically important. Overlapping missions that compete for the same resources, ground rules, safety requirements, and the unique needs of processing vehicles and payloads destined for space impose numerous constraints that, when combined, require advanced scheduling. Traditional scheduling systems use simple algorithms and criteria when selecting activities and assigning resources and times to each activity. Schedules generated by these simple decision rules are, however, frequently far from optimal. To resolve mission-critical scheduling issues and predict possible problem areas, NASA historically relied upon expert human schedulers who used their judgment and experience to determine where things should happen, whether they will happen on time, and whether the requested resources are truly necessary.

  18. Astronaut Office Scheduling System Software

    NASA Technical Reports Server (NTRS)

    Brown, Estevancio

    2010-01-01

    AOSS is a highly efficient scheduling application that uses various tools to schedule astronauts weekly appointment information. This program represents an integration of many technologies into a single application to facilitate schedule sharing and management. It is a Windows-based application developed in Visual Basic. Because the NASA standard office automation load environment is Microsoft-based, Visual Basic provides AO SS developers with the ability to interact with Windows collaboration components by accessing objects models from applications like Outlook and Excel. This also gives developers the ability to create newly customizable components that perform specialized tasks pertaining to scheduling reporting inside the application. With this capability, AOSS can perform various asynchronous tasks, such as gathering/ sending/ managing astronauts schedule information directly to their Outlook calendars at any time.

  19. Scheduling prioritized patients in emergency department laboratories.

    PubMed

    Azadeh, A; Hosseinabadi Farahani, M; Torabzadeh, S; Baghersad, M

    2014-11-01

    This research focuses on scheduling patients in emergency department laboratories according to the priority of patients' treatments, determined by the triage factor. The objective is to minimize the total waiting time of patients in the emergency department laboratories with emphasis on patients with severe conditions. The problem is formulated as a flexible open shop scheduling problem and a mixed integer linear programming model is proposed. A genetic algorithm (GA) is developed for solving the problem. Then, the response surface methodology is applied for tuning the GA parameters. The algorithm is tested on a set of real data from an emergency department. Simulation results show that the proposed algorithm can significantly improve the efficiency of the emergency department by reducing the total waiting time of prioritized patients. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  20. Gang scheduling a parallel machine

    SciTech Connect

    Gorda, B.C.; Brooks, E.D. III.

    1991-03-01

    Program development on parallel machines can be a nightmare of scheduling headaches. We have developed a portable time sharing mechanism to handle the problem of scheduling gangs of processors. User program and their gangs of processors are put to sleep and awakened by the gang scheduler to provide a time sharing environment. Time quantums are adjusted according to priority queues and a system of fair share accounting. The initial platform for this software is the 128 processor BBN TC2000 in use in the Massively Parallel Computing Initiative at the Lawrence Livermore National Laboratory. 2 refs., 1 fig.

  1. Gang scheduling a parallel machine

    SciTech Connect

    Gorda, B.C.; Brooks, E.D. III.

    1991-12-01

    Program development on parallel machines can be a nightmare of scheduling headaches. We have developed a portable time sharing mechanism to handle the problem of scheduling gangs of processes. User programs and their gangs of processes are put to sleep and awakened by the gang scheduler to provide a time sharing environment. Time quantum are adjusted according to priority queues and a system of fair share accounting. The initial platform for this software is the 128 processor BBN TC2000 in use in the Massively Parallel Computing Initiative at the Lawrence Livermore National Laboratory.

  2. Immunization Schedules for Infants and Children

    MedlinePlus

    ... ACIP Vaccination Recommendations Why Immunize? Vaccines: The Basics Immunization Schedules for Infants and Children United States, 2017 ... any questions. View or Print a Schedule Recommended Immunizations for Children (Birth through 6 years) Schedule for ...

  3. Schedule-Report-Generator Computer Program

    NASA Technical Reports Server (NTRS)

    Collazo, Fernando F.

    1990-01-01

    Schedule Report Generator provides simple method for generating periodic schedule reports. Enables engineering manager to monitor tasks assigned to staff members on weekly basis. Sorts three types of reports by use of one or more data fields as sorting keys. Schedule Organizer (SO) (COSMIC program MSC-21525), Schedule Tracker (ST) (COSMIC program MSC-21526), and Schedule Report Generator (SRG) computer programs manipulating data-base files in ways advantageous in scheduling. Written in PL/1 and DEC Command Language (DCL).

  4. Unintended effects of reimbursement schedules in mental health care.

    PubMed

    Douven, Rudy; Remmerswaal, Minke; Mosca, Ilaria

    2015-07-01

    We evaluate the introduction of a reimbursement schedule for self-employed mental health care providers in the Netherlands in 2008. The reimbursement schedule follows a discontinuous discrete step function-once the provider has passed a treatment duration threshold the fee is flat until a next threshold is reached. We use administrative mental health care data of the total Dutch population from 2008 to 2010. We find an "efficiency" effect: on the flat part of the fee schedule providers reduce treatment duration by 2 to 7% compared to a control group. However, we also find unintended effects: providers treat patients longer to reach a next threshold and obtain a higher fee. The data shows gaps and bunches in the distribution function of treatment durations, just before and after a threshold. About 11 to 13% of treatments are shifted over a next threshold, resulting in a cost increase of approximately 7 to 9%. Copyright © 2015 Elsevier B.V. All rights reserved.

  5. The GBT Dynamic Scheduling System

    NASA Astrophysics Data System (ADS)

    McCarty, M. T.; Balser, D. S.; Braatz, J.; Clark, M. H.; Condon, J.; Creager, R. E.; Maddalena, R. J.; Marganian, P.; O'Neil, K.; Sessoms, E.; Shelton, A. L.

    2012-09-01

    The Robert C. Byrd Green Bank Telescope (GBT) Dynamic Scheduling System (DSS), in use since September, 2009, was designed to maximize observing efficiency while preserving telescope flexibility and data quality without creating undue adversity for the observers. Using observing criteria; observer availability and qualifications for remote observing; three-dimensional weather forecasts; and telescope state, the DSS software optimally schedules observers 24 to 48 hours in advance for a telescope that has a wide-range of capabilities and a geographical location with variable weather patterns. The DSS project was closed October 28, 2011 and will now enter a continuing maintenance and enhancement phase. Recent improvements include a new resource calendar for incorporating telescope maintenance activities, a sensitivity calculator that leverages the scheduling algorithms to facilitate consistent tools for proposal preparation, improved support for monitoring observations, scheduling of high frequency continuum and spectral line observations for both sparse and fully sampled array receivers, and additional session parameters for observations having special requirements.

  6. Scheduling Spitzer: The SIRPASS Story

    NASA Technical Reports Server (NTRS)

    Mittman, David S.; Hawkins, Robert

    2013-01-01

    NASA's Spitzer Space Telescope was launched on August 25, 2003 from Florida's Cape Canaveral Air Force Base. Drifting in a unique Earth-trailing orbit around the Sun, Spitzer sees an optically invisible universe dominated by dust and stars. Since 1997, the Spitzer Integrated Resource Planning and Scheduling System (SIRPASS) has helped produce spacecraft activity plans for the Spitzer Space Telescope. SIRPASS is used by members of the Observatory Planning and Scheduling Team to plan, schedule and sequence the Telescope from data made available to them from the science and engineering community. Because of the volume of data that needs to be scheduled, SIRPASS offers a variety of automated assistants to aid in this task. This paper will describe the functional elements of the SIRPASS software system -- emphasizing the role that automation plays in the system -- and will highlight lessons learned for the software developer from a decade of Spitzer Space Telescope operations experience.

  7. Future aircraft networks and schedules

    NASA Astrophysics Data System (ADS)

    Shu, Yan

    2011-07-01

    Because of the importance of air transportation scheduling, the emergence of small aircraft and the vision of future fuel-efficient aircraft, this thesis has focused on the study of aircraft scheduling and network design involving multiple types of aircraft and flight services. It develops models and solution algorithms for the schedule design problem and analyzes the computational results. First, based on the current development of small aircraft and on-demand flight services, this thesis expands a business model for integrating on-demand flight services with the traditional scheduled flight services. This thesis proposes a three-step approach to the design of aircraft schedules and networks from scratch under the model. In the first step, both a frequency assignment model for scheduled flights that incorporates a passenger path choice model and a frequency assignment model for on-demand flights that incorporates a passenger mode choice model are created. In the second step, a rough fleet assignment model that determines a set of flight legs, each of which is assigned an aircraft type and a rough departure time is constructed. In the third step, a timetable model that determines an exact departure time for each flight leg is developed. Based on the models proposed in the three steps, this thesis creates schedule design instances that involve almost all the major airports and markets in the United States. The instances of the frequency assignment model created in this thesis are large-scale non-convex mixed-integer programming problems, and this dissertation develops an overall network structure and proposes iterative algorithms for solving these instances. The instances of both the rough fleet assignment model and the timetable model created in this thesis are large-scale mixed-integer programming problems, and this dissertation develops subproblem schemes for solving these instances. Based on these solution algorithms, this dissertation also presents

  8. Planning and scheduling for success

    NASA Technical Reports Server (NTRS)

    Manzanera, Ignacio

    1994-01-01

    Planning and scheduling programs are excellent management tools when properly introduced to the project management team and regularly maintained. Communications, creativity, flexibility and accuracy are substantially improved by following a simple set of rules. A planning and scheduling program will work for you if you believe in it, make others in your project team realize its benefits, and make it an extension of your project cost control philosophy.

  9. Construction schedules slack time minimizing

    NASA Astrophysics Data System (ADS)

    Krzemiński, Michał

    2017-07-01

    The article presents two copyright models for minimizing downtime working brigades. Models have been developed for construction schedules performed using the method of work uniform. Application of flow shop models is possible and useful for the implementation of large objects, which can be divided into plots. The article also presents a condition describing gives which model should be used, as well as a brief example of optimization schedule. The optimization results confirm the legitimacy of the work on the newly-developed models.

  10. Computerized scheduling of longwall moves

    SciTech Connect

    Patrick, C.

    1996-12-31

    The disassembly, transport, and reassembly of approximately 3,000 tons of equipment in as short a time as possible is very complex. The encumbered space and geological dynamics of the underground environment further complicate the planning, scheduling, and control of the longwall equipment move or face-to-face transfer. In the US, longwall move time greatly varies from a minimum of three days to more than twenty days. While some of this variation can be attributed to differing geologic conditions, mining systems, and move techniques, the organization and management of the longwall move process is a primary factor in move duration. The application of computer-based project scheduling to maintain and control the multitude of interacting resources and activities is demonstrated. This paper details an ongoing investigation of the application of computer scheduling to US longwall moves. An overview of the scheduling and analysis of longwall moves over the last five years is provided. This includes project task definition and level of detail, establishment of task relationships and sequences, task time estimation, and resource allocation and leveling. The paper further discusses, relative to longwall moves, computer application factors, modeling considerations, and assessments of software for computerized scheduling. The accompanying presentation will provide a demonstration of current project scheduling software as applied to actual longwall move processes.

  11. Instantiating a mechatronic valve schedule for a hydrocephalus shunt.

    PubMed

    Momani, Lina; Alkharabsheh, Abdel Rahman; Al-Zuibi, Nayel; Al-Nuaimy, Waleed

    2009-01-01

    Hydrocephalus is caused by blockage or reabsorption difficulty that upsets the natural balance of production and absorption of cerebrospinal fluid in the brain, resulting in a build-up of the fluid in the ventricles of the brain. One of the recent advances in the treatment of hydrocephalus is the invention of a mechatronic valve. The desirability of such valve lies in the potential of having shunt that not only control hydrocephalus but also seeks to treat it. In contrast to current valves, such a valve is regulated based on a time based schedule not on the differential pressure across the valve. Thus the effectiveness of such valve is highly dependant on selecting an appropriate valve schedule that delivers personal dynamic treatment for every individual patient. Providing such a schedule is likely to be one of the obstacles facing the implementation of the mechatronic valve. In this paper, an algorithm is proposed to help in developing such a schedule that dynamically change based on the patients' own intracranial pressure data and a novel figure of merit, thus providing the physician with an easy tool that facilitate the use of the mechatronic valve. The algorithm was implemented in M ATLAB and Simulink. Real ICP data for three hydrocephalus patients (before shunting) were used to test this algorithm and the resulted schedules along with the resulted intracranial pressure data have illustrated the effectiveness of the algorithm in providing schedule that maintain ICP within the normal limits.

  12. [Adapting immunisation schedules for children undergoing chemotherapy].

    PubMed

    Fernández-Prada, María; Rodríguez-Martínez, María; García-García, Rebeca; García-Corte, María Dolores; Martínez-Ortega, Carmen

    2016-10-20

    Children undergoing chemotherapy for cancer have special vaccination needs after completion of the treatment. The aim of this study was to evaluate the adaptation of post-chemotherapy vaccination schedules. An observational study was performed on a retrospective cohort that included all children aged from 0 to 14 years, who completed chemotherapy in a tertiary hospital between 2009 and 2015. Inclusion and exclusion criteria were applied. Immunisation was administered in accordance with the guidelines of the Vaccine Advisory Committee of the Spanish Association of Paediatrics. Primary Care immunisation and clinical records of the Preventive Medicine and Public Health Department were reviewed. Of the 99 children who had received chemotherapy, 51 (70.6% males) were included in the study. As regards the type of tumour, 54.9% had a solid organ tumour, and 45.1% had a haematological tumour. Post-chemotherapy immunisation was administered to 70.6%. The most common vaccines received were: diphtheria-tetanus-pertussis or diphtheria-tetanus (54.9%), meningococcus C (41.2%), and seasonal influenza (39.2%). The rate of adaptation of the immunisation schedule after chemotherapy was 9.8%. The pneumococcal conjugate vaccine against 7v or 13v was administered to 21.6% of study subjects. However, only 17.6% received polysaccharide 23v. None received vaccination against hepatitis A. No statistically significant differences were observed between adherence to immunisation schedules and type of tumour (P=.066), gender (P=.304), or age (P=.342). Post-chemotherapy immunisation of children with cancer is poor. The participation of health professionals in training programs and referral of paediatric cancer patients to Vaccine Units could improve the rate of schedule adaptation and proper immunisation of this population. Copyright © 2016 Elsevier España, S.L.U. and Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica. All rights reserved.

  13. Grid Patient Appointment Template Design to Improve Scheduling Effectiveness.

    PubMed

    Huang, Yu-Li; Marcak, Justin

    2015-01-01

    Current outpatient delivery systems have been problematic in their ability to effectively schedule appointments and grant patients access to care. A better appointment system has demonstrated improvement on these issues. The objective of this study is to develop a grid appointment system to further improve the scheduling flexibility by determining the minimum length of appointment slots that optimizes the total costs of patient waiting, physician idling, and overtime. This minimum length is used for the patient type requiring the least amount of treatment time such as return visit (RV), and multiplications of the minimum length are for patient types with longer treatment such as new patients (NP). The results indicated that the proposed grid system adjusts to demand changes at least 15% more cost-effective when grouping two RVs into an NP or dividing an NP into two RVs compared to the base-line scheduling approaches that build around the mean treatment time.

  14. 46 CFR 525.2 - Terminal schedules.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 9 2012-10-01 2012-10-01 false Terminal schedules. 525.2 Section 525.2 Shipping FEDERAL MARITIME COMMISSION REGULATIONS AFFECTING OCEAN SHIPPING IN FOREIGN COMMERCE MARINE TERMINAL OPERATOR SCHEDULES § 525.2 Terminal schedules. (a) Marine terminal operator schedules. A marine terminal operator, at...

  15. Evaluation of 4 X 4 Block Schedule.

    ERIC Educational Resources Information Center

    Mutter, Davida W.; And Others

    1997-01-01

    Describes 4 X 4 block scheduling and its advantages and disadvantages. Examines block scheduling's effects on a Virginia high school's students, teachers, and administration, based on school data and survey results. Most participants preferred block scheduling over the six-period schedule. Grades, attendance, and discipline improved; students…

  16. Batch Scheduling a Fresh Approach

    NASA Technical Reports Server (NTRS)

    Cardo, Nicholas P.; Woodrow, Thomas (Technical Monitor)

    1994-01-01

    The Network Queueing System (NQS) was designed to schedule jobs based on limits within queues. As systems obtain more memory, the number of queues increased to take advantage of the added memory resource. The problem now becomes too many queues. Having a large number of queues provides users with the capability to gain an unfair advantage over other users by tailoring their job to fit in an empty queue. Additionally, the large number of queues becomes confusing to the user community. The High Speed Processors group at the Numerical Aerodynamics Simulation (NAS) Facility at NASA Ames Research Center developed a new approach to batch job scheduling. This new method reduces the number of queues required by eliminating the need for queues based on resource limits. The scheduler examines each request for necessary resources before initiating the job. Also additional user limits at the complex level were added to provide a fairness to all users. Additional tools which include user job reordering are under development to work with the new scheduler. This paper discusses the objectives, design and implementation results of this new scheduler

  17. Environmental surveillance master sampling schedule

    SciTech Connect

    Bisping, L.E.

    1991-01-01

    Environmental surveillance of the Hanford Site and surrounding areas is conducted by the Pacific Northwest Laboratory (PNL) for the US Department of Energy (DOE). This document contains the planned schedule for routine sample collection for the Surface Environmental Surveillance Project (SESP) and Ground-Water Monitoring Project. The routine sampling plan for the SESP has been revised this year to reflect changing site operations and priorities. Some sampling previously performed at least annually has been reduced in frequency, and some new sampling to be performed at a less than annual frequency has been added. Therefore, the SESP schedule reflects sampling to be conducted in calendar year 1991 as well as future years. The ground-water sampling schedule is for 1991. This schedule is subject to modification during the year in response to changes in Site operation, program requirements, and the nature of the observed results. Operational limitations such as weather, mechanical failures, sample availability, etc., may also require schedule modifications. Changes will be documented in the respective project files, but this plan will not be reissued. The purpose of these monitoring projects is to evaluate levels of radioactive and nonradioactive pollutants in the Hanford evirons.

  18. Batch Scheduling a Fresh Approach

    NASA Technical Reports Server (NTRS)

    Cardo, Nicholas P.; Woodrow, Thomas (Technical Monitor)

    1994-01-01

    The Network Queueing System (NQS) was designed to schedule jobs based on limits within queues. As systems obtain more memory, the number of queues increased to take advantage of the added memory resource. The problem now becomes too many queues. Having a large number of queues provides users with the capability to gain an unfair advantage over other users by tailoring their job to fit in an empty queue. Additionally, the large number of queues becomes confusing to the user community. The High Speed Processors group at the Numerical Aerodynamics Simulation (NAS) Facility at NASA Ames Research Center developed a new approach to batch job scheduling. This new method reduces the number of queues required by eliminating the need for queues based on resource limits. The scheduler examines each request for necessary resources before initiating the job. Also additional user limits at the complex level were added to provide a fairness to all users. Additional tools which include user job reordering are under development to work with the new scheduler. This paper discusses the objectives, design and implementation results of this new scheduler

  19. The sleeping giant: Reinforcement schedules

    PubMed Central

    Zeiler, Michael D.

    1984-01-01

    Schedule research has been the core of operant conditioning, but it is no longer an active area, at least with respect to its traditional focus of describing and explaining moment-to-moment behavior. Yet schedules are central in psychology: Not only do they establish lawful behavior, but they also play a major role in determining the effects of other variables. The reason for the decline appears to be primarily theoretical, in that the work seems not to have led to meaningful integration. The search for controlling variables brought into play by schedule specification has proven unsuccessful, and a catalog of all possible schedule effects is of limited interest. The paper reviews the reasons for the contemporary state of affairs. One prediction about future developments is that instead of revealing component variables and their modes of interaction, schedule effects will be treated as basic empirical laws. Theory will take the form of abstract statements that integrate these separate laws by reference to higher-order principles rather than by reduction to supposedly simpler component variables. PMID:16812403

  20. Scheduling: A guide for program managers

    NASA Technical Reports Server (NTRS)

    1994-01-01

    The following topics are discussed concerning scheduling: (1) milestone scheduling; (2) network scheduling; (3) program evaluation and review technique; (4) critical path method; (5) developing a network; (6) converting an ugly duckling to a swan; (7) network scheduling problem; (8) (9) network scheduling when resources are limited; (10) multi-program considerations; (11) influence on program performance; (12) line-of-balance technique; (13) time management; (14) recapitulization; and (15) analysis.

  1. Artificial intelligence approaches to astronomical observation scheduling

    NASA Technical Reports Server (NTRS)

    Johnston, Mark D.; Miller, Glenn

    1988-01-01

    Automated scheduling will play an increasing role in future ground- and space-based observatory operations. Due to the complexity of the problem, artificial intelligence technology currently offers the greatest potential for the development of scheduling tools with sufficient power and flexibility to handle realistic scheduling situations. Summarized here are the main features of the observatory scheduling problem, how artificial intelligence (AI) techniques can be applied, and recent progress in AI scheduling for Hubble Space Telescope.

  2. Robust stochastic mine production scheduling

    NASA Astrophysics Data System (ADS)

    Kumral, Mustafa

    2010-06-01

    The production scheduling of open pit mines aims to determine the extraction sequence of blocks such that the net present value (NPV) of a mining project is maximized under capacity and access constraints. This sequencing has significant effect on the profitability of the mining venture. However, given that the values of coefficients in the optimization procedure are obtained in a medium of sparse data and unknown future events, implementations based on deterministic models may lead to destructive consequences to the company. In this article, a robust stochastic optimization (RSO) approach is used to deal with mine production scheduling in a manner such that the solution is insensitive to changes in input data. The approach seeks a trade off between optimality and feasibility. The model is demonstrated on a case study. The findings showed that the approach can be used in mine production scheduling problems efficiently.

  3. Fuzzy scheduled RTDA controller design.

    PubMed

    Srinivasan, K; Anbarasan, K

    2013-03-01

    In this paper, the design and development of fuzzy scheduled robustness, tracking, disturbance rejection and overall aggressiveness (RTDA) controller design for non-linear processes are discussed. pH process is highly non-linear and the design of good controller for this process is always a challenging one due to large gain variation. Fuzzy scheduled RTDA controller design based on normalized integral square error (N_ISE) performance criteria for pH neutralization process is developed. The applicability of the proposed controller is tested for other different non-linear processes like type I diabetic process and conical tank process. The servo and regulatory performance of fuzzy scheduled RTDA controller design is compared with well-tuned internal model control (IMC) and dynamic matrix control (DMC)-based control schemes. Copyright © 2012 ISA. Published by Elsevier Ltd. All rights reserved.

  4. Environmental surveillance master sampling schedule

    SciTech Connect

    Bisping, L.E.

    1997-01-01

    Environmental surveillance of the Hanford Site and surrounding areas is conducted by the Pacific Northwest National Laboratory (PNNL)(a) for the US Department of Energy (DOE). This document contains the planned 1997 schedules for routine collection of samples for the Surface Environmental Surveillance Project (SESP) and Drinking Water Monitoring Project. In addition, Section 3.0, Biota, also reflects a rotating collection schedule identifying the year a specific sample is scheduled for collection. The purpose of these monitoring projects is to evaluate levels of radioactive and nonradioactive pollutants in the Hanford environs, as required in DOE Order 5400.1, General Environmental Protection Program, and DOE Order 5400.5, Radiation Protection of the Public and the Environment. The sampling methods will be the same as those described in the Environmental Monitoring Plan, US Department of Energy, Richland Operations Office, DOE/RL91-50, Rev. 1, US Department of Energy, Richland, Washington.

  5. Optimal randomized scheduling by replacement

    SciTech Connect

    Saias, I.

    1996-05-01

    In the replacement scheduling problem, a system is composed of n processors drawn from a pool of p. The processors can become faulty while in operation and faulty processors never recover. A report is issued whenever a fault occurs. This report states only the existence of a fault but does not indicate its location. Based on this report, the scheduler can reconfigure the system and choose another set of n processors. The system operates satisfactorily as long as, upon report of a fault, the scheduler chooses n non-faulty processors. We provide a randomized protocol maximizing the expected number of faults the system can sustain before the occurrence of a crash. The optimality of the protocol is established by considering a closely related dual optimization problem. The game-theoretic technical difficulties that we solve in this paper are very general and encountered whenever proving the optimality of a randomized algorithm in parallel and distributed computation.

  6. Scheduling Linearly Indexed Assignment Codes

    NASA Astrophysics Data System (ADS)

    Kailath, Thomas; Roychowdhury, Vwani P.

    1989-05-01

    It has been recently shown that linearly indexed Assignment Codes can be efficiently used for coding several problems especially in signal processing and matrix algebra. In fact, mathematical expressions for many algorithms are directly in the form of linearly indexed codes, and examples include the formulas for matrix multiplication, any m-dimensional convolution/correlation, matrix transposition, and solving matrix Lyapunov's equation. Systematic procedures for converting linearly indexed Assignment Codes to localized algorithms that are closely related to Regular Iterative Algorithms (RIAs) have also been developed. These localized algorithms can be often efficiently scheduled by modeling them as RIAs; however, it is not always efficient to do so. In this paper we shall analyze and develop systematic procedures for determining efficient schedules directly for the linearly indexed ACs and the localized algorithms. We shall also illustrate our procedures by determining schedules for examples such as matrix transposition and Gauss-Jordan elimination algorithm.

  7. Feature-based telescope scheduler

    NASA Astrophysics Data System (ADS)

    Naghib, Elahesadat; Vanderbei, Robert J.; Stubbs, Christopher

    2016-07-01

    Feature-based Scheduler offers a sequencing strategy for ground-based telescopes. This scheduler is designed in the framework of Markovian Decision Process (MDP), and consists of a sub-linear online controller, and an offline supervisory control-optimizer. Online control law is computed at the moment of decision for the next visit, and the supervisory optimizer trains the controller by simulation data. Choice of the Differential Evolution (DE) optimizer, and introducing a reduced state space of the telescope system, offer an efficient and parallelizable optimization algorithm. In this study, we applied the proposed scheduler to the problem of Large Synoptic Survey Telescope (LSST). Preliminary results for a simplified model of LSST is promising in terms of both optimality, and computational cost.

  8. Tolerability and efficacy of a three-age class dosage schedule of Diethylcarbamazine citrate (DEC) in the treatment of microfilaria carriers of Wuchereria bancrofti and its implications in mass drug administration (MDA) strategy for elimination of lymphatic filariasis (LF).

    PubMed

    Pani, S P; Das, L K; Vanamail, P

    2005-03-01

    A six-age class dosage schedule of Diethylcarbamazine (DEC) of 50mg (1-2 years), 100mg (3-4 years), 150mg (5-8 years), 200mg (9-11 years), 250mg (12-14 years) and 300mg for above 14 years is being adopted for annual single dose MDA for LF elimination treat Wuchereria bancrofti microfilaria carriers. In order to increase the community compliance as well as to make the distribution easier during MDA, a revised 3 age class dosage schedule of 100mg (2-4 years), 200mg (5-14 years) and 300mg for above 14 years was evaluated for its tolerability and efficacy. By this change, it was observed that the 4-8 years age class is receiving 50 mg higher and 11-14 years age class is receiving 50mg lesser dose compared to the earlier class schedule. Therefore, the safety aspect in the age class of 4-8 years and efficacy component in the age class of 11-14 years were assessed. Apparently "healthy" asymptomatic microfilaraemic volunteers between the age class of 4-8 and 11-14 years were recruited for the study. The incidence of side reaction in the 4-8 years age class was 50.0% with 150mg dose and 66.7% with 200mg (P>0.05). No life threatening adverse reactions was observed in any dosage schedule. Fever, headache and myalgia, the predominant adverse reactions were mild and similar in both schedules. The mean intensity of the three major specific adverse reactions (fever, headache and myalgia) also did not differ significantly (P>0.05). For the purpose of LF elimination, efficacy in terms of reduction in mean microfilaria load is important. In the 11-14 year age class considerable reduction in the geometric mean density (GMD) was observed by day 90 and 180 post-therapy in both groups (250mg group and 200mg group) compared to pre-therapy level. By day 360 post-therapy, the difference was statistically not significant (P>0.05) (reduction of 72.2% in 250mg and 69.6% reduction in 200mg). The reductions in GMD were statistically significant when compared to pre-therapy levels in both the

  9. Computerized Schedule Effectiveness Technique /SET/ determines present and future schedule position

    NASA Technical Reports Server (NTRS)

    Ballard, D.; Birdsong, J.; Calva, R.

    1967-01-01

    Computerized scheduling system calculates an index of overall schedule-effectiveness. The schedule-effectiveness index is a measurement of actual overall performance against the existing schedule, and a series of schedule-effectiveness values indicates the trend of actual performance. This computer program is written in Fortran 4.

  10. A Generic Expert Scheduling System Architecture and Toolkit: GUESS (Generically Used Expert Scheduling System)

    NASA Technical Reports Server (NTRS)

    Liebowitz, Jay; Krishnamurthy, Vijaya; Rodens, Ira; Houston, Chapman; Liebowitz, Alisa; Baek, Seung; Radko, Joe; Zeide, Janet

    1996-01-01

    Scheduling has become an increasingly important element in today's society and workplace. Within the NASA environment, scheduling is one of the most frequently performed and challenging functions. Towards meeting NASA's scheduling needs, a research version of a generic expert scheduling system architecture and toolkit has been developed. This final report describes the development and testing of GUESS (Generically Used Expert Scheduling System).

  11. Micro-Opportunistic Scheduling: The Micro-Boss Factory Scheduler

    DTIC Science & Technology

    1994-01-01

    A major challenge for research in production management is to develop new finite-capacity scheduling techniques and tools that (1) can account more...precisely for actual production management constraints and objectives, (2) are better suited for handling production contingencies, and (3) allow the

  12. Scheduling Tasks In Parallel Processing

    NASA Technical Reports Server (NTRS)

    Price, Camille C.; Salama, Moktar A.

    1989-01-01

    Algorithms sought to minimize time and cost of computation. Report describes research on scheduling of computations tasks in system of multiple identical data processors operating in parallel. Computational intractability requires use of suboptimal heuristic algorithms. First algorithm called "list heuristic", variation of classical list scheduling. Second algorithm called "cluster heuristic" applied to tightly coupled tasks and consists of four phases. Third algorithm called "exchange heuristic", iterative-improvement algorithm beginning with initial feasible assignment of tasks to processors and periods of time. Fourth algorithm is iterative one for optimal assignment of tasks and based on concept called "simulated annealing" because of mathematical resemblance to aspects of physical annealing processes.

  13. Hubble Systems Optimize Hospital Schedules

    NASA Technical Reports Server (NTRS)

    2009-01-01

    Don Rosenthal, a former Ames Research Center computer scientist who helped design the Hubble Space Telescope's scheduling software, co-founded Allocade Inc. of Menlo Park, California, in 2004. Allocade's OnCue software helps hospitals reclaim unused capacity and optimize constantly changing schedules for imaging procedures. After starting to use the software, one medical center soon reported noticeable improvements in efficiency, including a 12 percent increase in procedure volume, 35 percent reduction in staff overtime, and significant reductions in backlog and technician phone time. Allocade now offers versions for outpatient and inpatient magnetic resonance imaging (MRI), ultrasound, interventional radiology, nuclear medicine, Positron Emission Tomography (PET), radiography, radiography-fluoroscopy, and mammography.

  14. A planning and scheduling lexicon

    NASA Technical Reports Server (NTRS)

    Cruz, Jennifer W.; Eggemeyer, William C.

    1989-01-01

    A lexicon related to mission planning and scheduling for spacecraft is presented. Planning and scheduling work is known as sequencing. Sequencing is a multistage process of merging requests from both the science and engineering arenas to accomplish the objectives defined in the requests. The multistage process begins with the creation of science and engineering goals, continues through their integration into the sequence, and eventually concludes with command execution onboard the spacecraft. The objective of this publication is to introduce some formalism into the field of spacecraft sequencing-system technology. This formalism will make it possible for researchers and potential customers to communicate about system requirements and capabilities in a common language.

  15. Operations research methods improve chemotherapy patient appointment scheduling.

    PubMed

    Santibáñez, Pablo; Aristizabal, Ruben; Puterman, Martin L; Chow, Vincent S; Huang, Wenhai; Kollmannsberger, Christian; Nordin, Travis; Runzer, Nancy; Tyldesley, Scott

    2012-12-01

    Clinical complexity, scheduling restrictions, and outdated manual booking processes resulted in frequent clerical rework, long waitlists for treatment, and late appointment notification for patients at a chemotherapy clinic in a large cancer center in British Columbia, Canada. A 17-month study was conducted to address booking, scheduling and workload issues and to develop, implement, and evaluate solutions. A review of scheduling practices included process observation and mapping, analysis of historical appointment data, creation of a new performance metric (final appointment notification lead time), and a baseline patient satisfaction survey. Process improvement involved discrete event simulation to evaluate alternative booking practice scenarios, development of an optimization-based scheduling tool to improve scheduling efficiency, and change management for implementation of process changes. Results were evaluated through analysis of appointment data, a follow-up patient survey, and staff surveys. Process review revealed a two-stage scheduling process. Long waitlists and late notification resulted from an inflexible first-stage process. The second-stage process was time consuming and tedious. After a revised, more flexible first-stage process and an automated second-stage process were implemented, the median percentage of appointments exceeding the final appointment notification lead time target of one week was reduced by 57% and median waitlist size decreased by 83%. Patient surveys confirmed increased satisfaction while staff feedback reported reduced stress levels. Significant operational improvements can be achieved through process redesign combined with operations research methods.

  16. Optimizing radiotherapy schedules for elderly glioblastoma multiforme patients.

    PubMed

    Clarke, James W; Chang, Eric L; Levin, Victor A; Mayr, Nina A; Hong, Eugene; Cavaliere, Robert; Lo, Simon S

    2008-05-01

    Glioblastoma is the most common malignant primary brain tumor. Despite recent advances, the overall prognosis remains poor with median survivals of approximately 1 year and 5-year survivals of less than 5%. Efforts at risk stratification have identified age and performance status as the most important prognostic features. It is well established that patients treated with postoperative radiation therapy have improved survival and functional capacity compared with unirradiated patients. Recent evidence suggests that the benefit of postoperative radiation persists even within the cohort aged 70 years or over. Some investigators have questioned whether the standard treatment schedule of 60 Gy delivered over a 6-week period is necessary for older patients with limited functional status. Alternative treatment schedules have been devised to reduce the inconvenience and morbidity of standard therapy. This review aims to evaluate the current state of knowledge on alternative radiotherapy schedules for elderly and poor-prognosis patients with glioblastoma.

  17. Environmental surveillance master sampling schedule

    SciTech Connect

    Bisping, L.E.

    1996-02-01

    Environmental surveillance of the Hanford Site and surrounding areas is conducted by the Pacific Northwest National Laboratory (PNNL) for the US Department of Energy (DOE). This document contains the planned 1996 schedules for routine collection of samples for the Surface Environmental Surveillance Project (SESP), Drinking Water Project, and Ground-Water Surveillance Project.

  18. Middle School Organization and Scheduling.

    ERIC Educational Resources Information Center

    McGinley, Nancy J.

    The major purpose of this report is to present information about the organization of middle schools in the school district of Philadelphia. The report includes: (1) summary information on rostering/scheduling practices; and (2) comparisons of promotion/retention rates, average daily attendance, and suspension rates in middle schools with different…

  19. Flexible Scheduling: Implementing an Innovation

    ERIC Educational Resources Information Center

    McGregor, Joy

    2006-01-01

    Teachers, school library media specialists (SLMSs), and principals in six elementary schools were interviewed to explore the ways in which schools have successfully implemented flexible scheduling in their libraries. Overall findings and conclusions of the study are linked with Rogers' diffusion of innovation theory and compared with Shannon's…

  20. Flexible Schedules and Shift Work.

    ERIC Educational Resources Information Center

    Beers, Thomas M.

    2000-01-01

    Flexible work hours have gained prominence, as more than 25 million workers (27.6% of all full-time workers) can now vary their schedules. However, there has been little change since the mid-1980s in the proportion who work a shift other than a regular daytime shift. (JOW)

  1. A scheduling model for astronomy

    NASA Astrophysics Data System (ADS)

    Solar, M.; Michelon, P.; Avarias, J.; Garces, M.

    2016-04-01

    Astronomical scheduling problem has several external conditions that change dynamically at any time during observations, like weather condition (humidity, temperature, wind speed, opacity, etc.), and target visibility conditions (target over the horizon, Sun/Moon blocking the target). Therefore, a dynamic re-scheduling is needed. An astronomical project will be scheduled as one or more Scheduling Blocks (SBs) as an atomic unit of astronomical observations. We propose a mixed integer linear programming (MILP) solution to select the best SBs, favors SBs with high scientific values, and thus maximizing the quantity of completed observation projects. The data content of Atacama Large Millimeter/Submillimeter Array (ALMA) projects of cycle 0 and cycle 1 were analyzed, and a synthetic set of tests of the real instances was created. Two configurations, one of 5000 SBs in a 3 months season and another 10,000 SBs a 6 months season were created. These instances were evaluated with excellent results. Through the testing it is showed that the MILP proposal has optimal solutions.

  2. 1996 Wholesale Power and Transmission Rate Schedules.

    SciTech Connect

    United States. Bonneville Power Administration.

    1996-10-01

    Bonneville Power Administration`s (BPA) 1996 Wholesale Power Rate Schedules, 1996 Ancillary Products and Services Rate Schedule, 1996 Transmission Rate Schedules, and General Rate Schedule Provisions, contained herein, were approved on an interim basis effective October 1, 1996. These rate schedules and provisions were approved by the Federal Energy Regulatory Commission (FERC), United States Department of Energy, in September 1996 (Docket Nos EF96-2011-000 and EF96f-2021-000). These rate schedules and General Rate Schedule Provisions were approved on a final basis by the FERC July 30, 1997, in Dept. of Energy--Bonneville Power Administration, Docket Nos. EF96-2011-000 and EF96-2021-000. Except as noted elsewhere, these 1996 rate schedules and provisions supersede BPA`s Wholesale Power Rate Schedules and General Rate Schedule Provisions, and Transmission Rate Schedules and General Transmission Rate Schedule Provisions, effective October 1, 1995. These rate schedules and general rate schedule provisions include all errata.

  3. User requirements for a patient scheduling system

    NASA Technical Reports Server (NTRS)

    Zimmerman, W.

    1979-01-01

    A rehabilitation institute's needs and wants from a scheduling system were established by (1) studying the existing scheduling system and the variables that affect patient scheduling, (2) conducting a human-factors study to establish the human interfaces that affect patients' meeting prescribed therapy schedules, and (3) developing and administering a questionnaire to the staff which pertains to the various interface problems in order to identify staff requirements to minimize scheduling problems and other factors that may limit the effectiveness of any new scheduling system.

  4. Adaptive Parallel Job Scheduling with Flexible CoScheduling

    SciTech Connect

    Frachtenberg, Eitan; Feitelson, Dror; Petrini, Fabrizio; Fernandez, Juan

    2005-11-01

    Abstract—Many scientific and high-performance computing applications consist of multiple processes running on different processors that communicate frequently. Because of their synchronization needs, these applications can suffer severe performance penalties if their processes are not all coscheduled to run together. Two common approaches to coscheduling jobs are batch scheduling, wherein nodes are dedicated for the duration of the run, and gang scheduling, wherein time slicing is coordinated across processors. Both work well when jobs are load-balanced and make use of the entire parallel machine. However, these conditions are rarely met and most realistic workloads consequently suffer from both internal and external fragmentation, in which resources and processors are left idle because jobs cannot be packed with perfect efficiency. This situation leads to reduced utilization and suboptimal performance. Flexible CoScheduling (FCS) addresses this problem by monitoring each job’s computation granularity and communication pattern and scheduling jobs based on their synchronization and load-balancing requirements. In particular, jobs that do not require stringent synchronization are identified, and are not coscheduled; instead, these processes are used to reduce fragmentation. FCS has been fully implemented on top of the STORM resource manager on a 256-processor Alpha cluster and compared to batch, gang, and implicit coscheduling algorithms. This paper describes in detail the implementation of FCS and its performance evaluation with a variety of workloads, including large-scale benchmarks, scientific applications, and dynamic workloads. The experimental results show that FCS saturates at higher loads than other algorithms (up to 54 percent higher in some cases), and displays lower response times and slowdown than the other algorithms in nearly all scenarios.

  5. A transportation-scheduling system for managing silvicultural projects

    Treesearch

    Jorge F. Valenzuela; H. Hakan Balci; Timothy McDonald

    2005-01-01

    A silvicultural project encompasses tasks such as sitelevel planning, regeneration, harvestin, and stand-tending treatments. an essential problem in managing silvicultural projects is to efficiently schedule the operations while considering project task due dates and costs of moving scarce resources to specific job locations. Transportation costs represent a...

  6. Concurrent Schedules of Reinforcement as "Challenges" to Maintenance

    ERIC Educational Resources Information Center

    Peterson, Stephanie M.; Frieder, Jessica E.; Quigley, Shawn P.; Kestner, Kathryn M.; Goyal, Manish; Smith, Shilo L.; Dayton, Elizabeth; Brower-Breitwieser, Carrie

    2017-01-01

    One measure of success for interventions treating problem behavior is the effects achieved in the face of a challenge (e.g., changes in reinforcement schedules, lapses in treatment integrity); one hopes to demonstrate persistence of appropriate alternatives and the absence of resurgence of target behaviors. The present study successfully treated…

  7. 77 FR 64848 - Proposed Collection; Comment Request for Form 1120S, Schedule D, Schedule K-1, and Schedule M-3

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-23

    ... Internal Revenue Service Proposed Collection; Comment Request for Form 1120S, Schedule D, Schedule K-1, and Schedule M-3 AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Notice and request for comments... assured of consideration. ADDRESSES: Direct all written comments to Yvette Lawrence, Internal...

  8. How should periods without social interaction be scheduled? Children's preference for practical schedules of positive reinforcement.

    PubMed

    Luczynski, Kevin C; Hanley, Gregory P

    2014-01-01

    Several studies have shown that children prefer contingent reinforcement (CR) rather than yoked noncontingent reinforcement (NCR) when continuous reinforcement is programmed in the CR schedule. Preference has not, however, been evaluated for practical schedules that involve CR. In Study 1, we assessed 5 children's preference for obtaining social interaction via a multiple schedule (periods of fixed-ratio 1 reinforcement alternating with periods of extinction), a briefly signaled delayed reinforcement schedule, and an NCR schedule. The multiple schedule promoted the most efficient level of responding. In general, children chose to experience the multiple schedule and avoided the delay and NCR schedules, indicating that they preferred multiple schedules as the means to arrange practical schedules of social interaction. In Study 2, we evaluated potential controlling variables that influenced 1 child's preference for the multiple schedule and found that the strong positive contingency was the primary variable.

  9. 29 CFR 1952.101 - Developmental schedule.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... (CONTINUED) APPROVED STATE PLANS FOR ENFORCEMENT OF STATE STANDARDS Oregon § 1952.101 Developmental schedule. The Oregon plan is developmental. The schedule of developmental steps as described in the plan...

  10. 29 CFR 1952.101 - Developmental schedule.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... (CONTINUED) APPROVED STATE PLANS FOR ENFORCEMENT OF STATE STANDARDS Oregon § 1952.101 Developmental schedule. The Oregon plan is developmental. The schedule of developmental steps as described in the plan...

  11. 29 CFR 1952.101 - Developmental schedule.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... (CONTINUED) APPROVED STATE PLANS FOR ENFORCEMENT OF STATE STANDARDS Oregon § 1952.101 Developmental schedule. The Oregon plan is developmental. The schedule of developmental steps as described in the plan...

  12. 29 CFR 1952.101 - Developmental schedule.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... (CONTINUED) APPROVED STATE PLANS FOR ENFORCEMENT OF STATE STANDARDS Oregon § 1952.101 Developmental schedule. The Oregon plan is developmental. The schedule of developmental steps as described in the plan...

  13. 48 CFR 245.606 - Inventory schedules.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Inventory schedules. 245.606 Section 245.606 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM... Contractor Inventory 245.606 Inventory schedules....

  14. A Decision Support System for Academic Scheduling.

    ERIC Educational Resources Information Center

    Burleson, Donald K.; Leivano, Rodrigo J.

    1986-01-01

    Describes the use of a decision support system to operate on a database for academic scheduling. Discusses the scheduling environment, database subsystem, dialog subsystem, modeling subsystem, and output formats. (JM)

  15. A DSN optimal spacecraft scheduling model

    NASA Technical Reports Server (NTRS)

    Webb, W. A.

    1982-01-01

    A computer model is described which uses mixed-integer linear programming to provide optimal DSN spacecraft schedules given a mission set and specified scheduling requirements. A solution technique is proposed which uses Bender's Method and a heuristic starting algorithm.

  16. 29 CFR 1952.123 - Developmental schedule.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... (CONTINUED) APPROVED STATE PLANS FOR ENFORCEMENT OF STATE STANDARDS Washington § 1952.123 Developmental schedule. The Washington State plan is developmental. The following is the developmental schedule as...

  17. 29 CFR 1952.221 - Developmental schedule.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... (CONTINUED) APPROVED STATE PLANS FOR ENFORCEMENT OF STATE STANDARDS Tennessee § 1952.221 Developmental schedule. The Tennessee state plan is developmental. The following is the developmental schedule as...

  18. Integrating protocol schedules with patients' personal calendars.

    PubMed

    Civan, Andrea; Gennari, John H; Pratt, Wanda

    2006-01-01

    We propose a new approach for integrating protocol care schedules into patients' personal calendars. This approach could provide patients with greater control over their current and future scheduling demands as they seek and receive protocol-based care.

  19. Scheduling from the perspective of the application

    SciTech Connect

    Berman, F.; Wolski, R.

    1996-12-31

    Metacomputing is the aggregation of distributed and high-performance resources on coordinated networks. With careful scheduling, resource-intensive applications can be implemented efficiently on metacomputing systems at the sizes of interest to developers and users. In this paper we focus on the problem of scheduling applications on metacomputing systems. We introduce the concept of application-centric scheduling in which everything about the system is evaluated in terms of its impact on the application. Application-centric scheduling is used by virtually all metacomputer programmers to achieve performance on metacomputing systems. We describe two successful metacomputing applications to illustrate this approach, and describe AppLeS scheduling agents which generalize the application-centric scheduling approach. Finally, we show preliminary results which compare AppLeS-derived schedules with conventional strip and blocked schedules for a two-dimensional Jacobi code.

  20. LDRD Report: Scheduling Irregular Algorithms

    SciTech Connect

    Boman, Erik G.

    2014-10-01

    This LDRD project was a campus exec fellowship to fund (in part) Donald Nguyen’s PhD research at UT-Austin. His work has focused on parallel programming models, and scheduling irregular algorithms on shared-memory systems using the Galois framework. Galois provides a simple but powerful way for users and applications to automatically obtain good parallel performance using certain supported data containers. The naïve user can write serial code, while advanced users can optimize performance by advanced features, such as specifying the scheduling policy. Galois was used to parallelize two sparse matrix reordering schemes: RCM and Sloan. Such reordering is important in high-performance computing to obtain better data locality and thus reduce run times.

  1. Models of ratio schedule performance.

    PubMed

    Bizo, L A; Killeen, P R

    1997-07-01

    Predictions of P. R. Killeen's (1994) mathematical principles of reinforcement were tested for responding on ratio reinforcement schedules. The type of response key, the number of sessions per condition, and first vs. second half of a session had negligible effects on responding. Longer reinforcer durations and larger grain types engendered more responding, affecting primarily the parameter alpha (specific activation). Key pecking was faster than treadle pressing, affecting primarily the parameter delta (response time). Longer intertrial intervals led to higher overall response rates and shorter postreinforcement pauses and higher running rates, and ruled out some competing explanations. The treadle data required a distinction between the energetic requirements and rate-limiting properties of extended responses. The theory was extended to predict pause durations and run rates on ratio schedules.

  2. Real-time scheduling using minimum search

    NASA Technical Reports Server (NTRS)

    Tadepalli, Prasad; Joshi, Varad

    1992-01-01

    In this paper we consider a simple model of real-time scheduling. We present a real-time scheduling system called RTS which is based on Korf's Minimin algorithm. Experimental results show that the schedule quality initially improves with the amount of look-ahead search and tapers off quickly. So it sppears that reasonably good schedules can be produced with a relatively shallow search.

  3. Intelsat satellite scheduled for launch

    NASA Technical Reports Server (NTRS)

    1981-01-01

    The launch schedule for Intelsat 5-B, the prime Intelsat satellite to provide communications services between the Americas, Europe, the Middle East, and Africa, is presented. The planned placement of the satellite into an elliptical transfer orbit, and circularization of the orbit at geosynchronous altitude over the equator are described. Characteristics of the Atlas Centaur launch vehicle, AC-56, are given. The launch operation is summarized and the launch sequence presented. The Intelsat team and contractors are listed.

  4. Environmental surveillance master sampling schedule

    SciTech Connect

    Bisping, L.E.

    1995-02-01

    Environmental surveillance of the Hanford Site and surrounding areas is conducted by the Pacific Northwest Laboratory (PNL) for the U.S. Department of Energy (DOE). This document contains the planned 1994 schedules for routine collection of samples for the Surface Environmental Surveillance Project (SESP), Drinking Water Project, and Ground-Water Surveillance Project. Samples are routinely collected for the SESP and analyzed to determine the quality of air, surface water, soil, sediment, wildlife, vegetation, foodstuffs, and farm products at Hanford Site and surrounding communities. The responsibility for monitoring onsite drinking water falls outside the scope of the SESP. PNL conducts the drinking water monitoring project concurrent with the SESP to promote efficiency and consistency, utilize expertise developed over the years, and reduce costs associated with management, procedure development, data management, quality control, and reporting. The ground-water sampling schedule identifies ground-water sampling .events used by PNL for environmental surveillance of the Hanford Site. Sampling is indicated as annual, semi-annual, quarterly, or monthly in the sampling schedule. Some samples are collected and analyzed as part of ground-water monitoring and characterization programs at Hanford (e.g. Resources Conservation and Recovery Act (RCRA), Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA), or Operational). The number of samples planned by other programs are identified in the sampling schedule by a number in the analysis column and a project designation in the Cosample column. Well sampling events may be merged to avoid redundancy in cases where sampling is planned by both-environmental surveillance and another program.

  5. Scheduled Peripheral Component Interconnect Arbiter

    NASA Technical Reports Server (NTRS)

    Nixon, Scott Alan (Inventor)

    2015-01-01

    Systems and methods are described for arbitrating access of a communication bus. In one embodiment, a method includes performing steps on one or more processors. The steps include: receiving an access request from a device of the communication bus; evaluating a bus schedule to determine an importance of the device based on the access request; and selectively granting access of the communication bus to the device based on the importance of the device.

  6. Environmental surveillance master sampling schedule

    SciTech Connect

    Bisping, L.E.

    1993-01-01

    Environmental surveillance of the Hanford Site and surrounding areas is conducted by the Pacific Northwest Laboratory (PNL) for the US Department of Energy (DOE). Samples are routinely collected and analyzed to determine the quality of air, surface water, ground water, soil, sediment, wildlife, vegetation, foodstuffs, and farm products at Hanford Site and surrounding communities. This document contains the planned schedule for routine sample collection for the Surface Environmental Surveillance Project (SESP) and Drinking Water Project, and Ground-Water Surveillance Project.

  7. Littoral Combat Ship Crew Scheduling

    DTIC Science & Technology

    2015-03-01

    Yet, even for a shorter-than-desired time horizon, it takes many hours of computation. Rolling horizon is a heuristic approach that produces a full...long- term schedule in under an hour but requires manual modifications to misaligned crews. Fix-and-relax is a more-elaborate heuristic with potential...18  4.  Explanation of Formulation ..............................................................21  B.  HEURISTIC SIMPLIFICATION

  8. A Comparison of Dense-to-Lean and Fixed Lean Schedules of Alternative Reinforcement and Extinction

    ERIC Educational Resources Information Center

    Hagopian, Louis P.; Toole, Lisa M.; Long, Ethan S.; Bowman, Lynn G.; Lieving, Gregory A.

    2004-01-01

    Behavior-reduction interventions typically employ dense schedules of alternative reinforcement in conjunction with operant extinction for problem behavior. After problem behavior is reduced in the initial treatment stages, schedule thinning is routinely conducted to make the intervention more practical in natural environments. In the current…

  9. The Effect of Changes in Criterion Value on Differential Reinforcement of Low Rate Schedule Performance

    ERIC Educational Resources Information Center

    Pizzo, Matthew J.; Kirkpatrick, Kimberly; Blundell, Pamela J.

    2009-01-01

    The differential reinforcement of low rate (DRL) schedule is commonly used to assess impulsivity, hyperactivity, and the cognitive effects of pharmacological treatments on performance. A DRL schedule requires subjects to wait a certain minimum amount of time between successive responses to receive reinforcement. The DRL criterion value, which…

  10. Concurrent reinforcement schedules: behavior change and maintenance without extinction.

    PubMed Central

    Hoch, Hannah; McComas, Jennifer J; Thompson, Andrea L; Paone, Debra

    2002-01-01

    We evaluated the effects of concurrent schedules of reinforcement on negatively reinforced problem behavior and task completion with 3 children with autism. Results indicated that problem behavior occurred at high levels and relatively few tasks were completed when problem behavior produced a break (from tasks) and task completion produced either no consequence or a break. By contrast, problem behavior was eliminated and tasks were completed when problem behavior produced a break and task completion produced a break with access to preferred activities. Treatment gains were maintained without the use of extinction when the response requirement was increased and the schedule of reinforcement was thinned. PMID:12102135

  11. Concurrent reinforcement schedules: behavior change and maintenance without extinction.

    PubMed

    Hoch, Hannah; McComas, Jennifer J; Thompson, Andrea L; Paone, Debra

    2002-01-01

    We evaluated the effects of concurrent schedules of reinforcement on negatively reinforced problem behavior and task completion with 3 children with autism. Results indicated that problem behavior occurred at high levels and relatively few tasks were completed when problem behavior produced a break (from tasks) and task completion produced either no consequence or a break. By contrast, problem behavior was eliminated and tasks were completed when problem behavior produced a break and task completion produced a break with access to preferred activities. Treatment gains were maintained without the use of extinction when the response requirement was increased and the schedule of reinforcement was thinned.

  12. 19 CFR 122.63 - Scheduled airlines.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Scheduled airlines. 122.63 Section 122.63 Customs... AIR COMMERCE REGULATIONS Clearance of Aircraft and Permission To Depart § 122.63 Scheduled airlines... scheduled airlines covered by this subpart. (a) Clearance at other than airport of final departure. Aircraft...

  13. 7 CFR 283.29 - Scheduling conference.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Scheduling conference. 283.29 Section 283.29... Procedure for Appeals of QC Claims of Less Than $50,000 § 283.29 Scheduling conference. (a) Time and place. The ALJ shall direct the parties or their counsel to attend a scheduling conference following...

  14. 40 CFR 52.1677 - Compliance schedules.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... sections 223.1(a), 225.3(c), and 230.2(d) of Subchapter A, Chapter III, Title 6 of New York State's... schedule for any source to which the application of the compliance schedule in paragraphs (d)(2), (3), (5... been submitted for every source for which they are required. (d) Federal compliance schedules. (1) The...

  15. 21 CFR 1308.49 - Emergency scheduling.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 9 2011-04-01 2011-04-01 false Emergency scheduling. 1308.49 Section 1308.49 Food... Hearings § 1308.49 Emergency scheduling. Pursuant to 21 U.S.C. 811(h) and without regard to the... the end of one year from the effective date of the order scheduling the substance, except that during...

  16. 7 CFR 283.29 - Scheduling conference.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 4 2011-01-01 2011-01-01 false Scheduling conference. 283.29 Section 283.29... Procedure for Appeals of QC Claims of Less Than $50,000 § 283.29 Scheduling conference. (a) Time and place. The ALJ shall direct the parties or their counsel to attend a scheduling conference following the...

  17. 48 CFR 2908.404 - Using schedules.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... SOURCES OF SUPPLIES AND SERVICES Federal Supply Schedules 2908.404 Using schedules. Small business... followed may be modified by the Office of Small Business Program as appropriate in order to comply with GSA Federal Supply Schedule procedures (e.g., first tier contracts may be required to report their commercial...

  18. Centralized scheduling an unanticipated revenue cycle opportunity.

    PubMed

    O'Neill, Daniel P; Kenniff, Peter B

    2007-09-01

    Centralized outpatient scheduling can provide acute care hospitals with accessibility and service levels equal to freestanding facilities, enabling hospitals to recapture lost market share. Two implementation strategies are critical to the success of centralized scheduling: Correctly developing the schedule. Managing the incoming call volume.

  19. 77 FR 41258 - FOIA Fee Schedule Update

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-13

    ... SAFETY BOARD 10 CFR Part 1703 FOIA Fee Schedule Update AGENCY: Defense Nuclear Facilities Safety Board. ACTION: Establishment of FOIA Fee Schedule. SUMMARY: The Defense Nuclear Facilities Safety Board is publishing its Freedom of Information Act (FOIA) Fee Schedule Update pursuant to the Board's...

  20. 76 FR 43819 - FOIA Fee Schedule Update

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-22

    ... SAFETY BOARD 10 CFR Part 1703 FOIA Fee Schedule Update AGENCY: Defense Nuclear Facilities Safety Board. ACTION: Establishment of FOIA Fee Schedule. SUMMARY: The Defense Nuclear Facilities Safety Board is publishing its Freedom of Information Act (FOIA) Fee Schedule Update pursuant to the Board's...

  1. 75 FR 39629 - FOIA Fee Schedule Update

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-12

    ... 1703 FOIA Fee Schedule Update AGENCY: Defense Nuclear Facilities Safety Board. ACTION: Establishment of FOIA Fee Schedule. SUMMARY: The Defense Nuclear Facilities Safety Board is publishing its Freedom of Information Act (FOIA) Fee Schedule Update pursuant to 10 CFR 1703.107(b)(6) of the Board's regulations....

  2. 7 CFR 58.440 - Make schedule.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 3 2013-01-01 2013-01-01 false Make schedule. 58.440 Section 58.440 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards... Procedures § 58.440 Make schedule. A uniform schedule should be established and followed as closely as...

  3. 7 CFR 58.440 - Make schedule.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 3 2014-01-01 2014-01-01 false Make schedule. 58.440 Section 58.440 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards... Procedures § 58.440 Make schedule. A uniform schedule should be established and followed as closely as...

  4. 7 CFR 58.440 - Make schedule.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Make schedule. 58.440 Section 58.440 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards... Procedures § 58.440 Make schedule. A uniform schedule should be established and followed as closely as...

  5. 7 CFR 58.440 - Make schedule.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 3 2012-01-01 2012-01-01 false Make schedule. 58.440 Section 58.440 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards... Procedures § 58.440 Make schedule. A uniform schedule should be established and followed as closely as...

  6. 7 CFR 58.440 - Make schedule.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 3 2011-01-01 2011-01-01 false Make schedule. 58.440 Section 58.440 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards... Procedures § 58.440 Make schedule. A uniform schedule should be established and followed as closely as...

  7. 15 CFR 400.44 - Zone schedule.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Executive Secretary (in both paper and electronic copies) a zone schedule which sets forth the elements required in this section. No element of a zone schedule (including any amendment to the zone schedule) may... table of contents; (3) Internal rules/regulations and policies for the zone; (4) All rates or...

  8. 40 CFR 52.524 - Compliance schedules.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 3 2010-07-01 2010-07-01 false Compliance schedules. 52.524 Section 52...) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS Florida § 52.524 Compliance schedules. (a) The requirements of § 51.262(a) of this chapter are not met since compliance schedules with adequate increments...

  9. 40 CFR 52.927 - Compliance schedules.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 3 2010-07-01 2010-07-01 false Compliance schedules. 52.927 Section 52...) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS Kentucky § 52.927 Compliance schedules. (a) The requirements of § 51.262(a) of this chapter are not met since compliance schedules with adequate increments...

  10. 40 CFR 52.134 - Compliance schedules.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 3 2010-07-01 2010-07-01 false Compliance schedules. 52.134 Section 52...) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS Arizona § 52.134 Compliance schedules. (a) Federal compliance schedule. (1) Except as provided in paragraph (a)(2) of this section, the owner or operator of...

  11. Response Strength in Extreme Multiple Schedules

    ERIC Educational Resources Information Center

    McLean, Anthony P.; Grace, Randolph C.; Nevin, John A.

    2012-01-01

    Four pigeons were trained in a series of two-component multiple schedules. Reinforcers were scheduled with random-interval schedules. The ratio of arranged reinforcer rates in the two components was varied over 4 log units, a much wider range than previously studied. When performance appeared stable, prefeeding tests were conducted to assess…

  12. Response Strength in Extreme Multiple Schedules

    ERIC Educational Resources Information Center

    McLean, Anthony P.; Grace, Randolph C.; Nevin, John A.

    2012-01-01

    Four pigeons were trained in a series of two-component multiple schedules. Reinforcers were scheduled with random-interval schedules. The ratio of arranged reinforcer rates in the two components was varied over 4 log units, a much wider range than previously studied. When performance appeared stable, prefeeding tests were conducted to assess…

  13. Reinforcement Schedule Effects on Long-Term Behavior Change

    PubMed Central

    Roll, John M.; McPherson, Sterling; Cameron, Jennifer M.; Howell, Donelle N.

    2015-01-01

    Objective The primary aim of this study was to determine whether different schedules of contingency management (CM), in conjunction with psychosocial treatment, produced different rates of abstinence and treatment attendance among individuals dependent on methamphetamine. Methods Individuals were randomized into 1 of 3 conditions that sought to equate total potential reinforcer magnitude while varying the frequency with which reinforcement was delivered, and comparing these results to those obtained when psychosocial support alone was used. Results Results indicate that all 3 CM schedules occasioned more abstinent attendance than the group only receiving psychosocial treatment. However, the 3 CM conditions did not differ in any appreciable way. Conclusions These results suggest that treatment providers may be able to decrease the frequency of reinforcer delivery in CM paradigms while retaining efficacy to treat psychostimulant use disorders. PMID:26139942

  14. Temporal knowledge representation for scheduling tasks in clinical trial protocols.

    PubMed Central

    Weng, Chunhua; Kahn, Michael; Gennari, John

    2002-01-01

    Clinical trial protocols include detailed temporal constraints on treatment and associated tasks. Unlike health-care guidelines, protocols are highly prescriptive. Therefore, informatics applications that enforce such temporal constraints are more directly useful with protocols than with guidelines. Although there are some temporal knowledge representation efforts for health-care guidelines, we find these to be insufficiently expressive for clinical trial protocols. In this paper, we focus on temporal knowledge representation for clinical trial protocols and the task of patient-specific scheduling in protocols. We define a temporal ontology, use it to encode clinical trial protocols, and describe a prototype tool to carry out patient-specific scheduling for the tasks in protocols. We predict that an expressive temporal knowledge representation can support a number of scheduling and management tasks for protocol-based care. PMID:12463951

  15. A novel evolutionary drug scheduling model in cancer chemotherapy.

    PubMed

    Liang, Yong; Leung, Kwong-Sak; Mok, Tony Shu Kam

    2006-04-01

    In this paper, we introduce a modified optimal control model of drug scheduling in cancer chemotherapy and a new adaptive elitist-population-based genetic algorithm (AEGA) to solve it. Working closely with an oncologist, we first modify the existing model, because its equation for the cumulative drug toxicity is inconsistent with medical knowledge and clinical experience. To explore multiple efficient drug scheduling policies, we propose a novel variable representation--a cycle-wise representation, and modify the elitist genetic search operators in the AEGA. The simulation results obtained by the modified model match well with the clinical treatment experiences, and can provide multiple efficient solutions for oncologists to consider. Moreover, it has been shown that the evolutionary drug scheduling approach is simple, and capable of solving complex cancer chemotherapy problems by adapting multimodal versions of evolutionary algorithms.

  16. 49 CFR Schedule C to Subpart B of... - Schedule C to Subpart B of Part 1139

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 8 2010-10-01 2010-10-01 false Schedule C to Subpart B of Part 1139 C Schedule C... REVENUE PROCEEDINGS Intercity Bus Industry Pt. 1139, Subpt. B, Sch. C Schedule C to Subpart B of Part 1139 Attachment 1 Schedule C Part I—Condensed Income Statement () Greyhound Lines, Inc.()Trailways combined() All...

  17. 49 CFR Schedule C to Subpart B of... - Schedule C to Subpart B of Part 1139

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 8 2014-10-01 2014-10-01 false Schedule C to Subpart B of Part 1139 C Schedule C... REVENUE PROCEEDINGS Intercity Bus Industry Pt. 1139, Subpt. B, Sch. C Schedule C to Subpart B of Part 1139 Attachment 1 Schedule C Part I—Condensed Income Statement () Greyhound Lines, Inc.()Trailways combined()...

  18. Fixed-time schedule effects in combination with response-dependent schedules.

    PubMed

    Borrero, John C; Bartels-Meints, Jamie A; Sy, Jolene R; Francisco, Monica T

    2011-01-01

    We evaluated the effects of fixed-interval (FI), fixed-time (FT), and conjoint (combined) FI FT reinforcement schedules on the responding of 3 adults who had been diagnosed with schizophrenia. Responding on vocational tasks decreased for 2 of 3 participants under FT alone relative to FI alone. Responding under FI FT resulted in response persistence for 2 of 3 participants. Results have implications for the maintenance of desirable behavior, as well as for situations in which FT treatment has been implemented for problem behavior and problem behavior is nevertheless reinforced by caregivers.

  19. FIXED-TIME SCHEDULE EFFECTS IN COMBINATION WITH RESPONSE-DEPENDENT SCHEDULES

    PubMed Central

    Borrero, John C; Bartels-Meints, Jamie A; Sy, Jolene R; Francisco, Monica T

    2011-01-01

    We evaluated the effects of fixed-interval (FI), fixed-time (FT), and conjoint (combined) FI FT reinforcement schedules on the responding of 3 adults who had been diagnosed with schizophrenia. Responding on vocational tasks decreased for 2 of 3 participants under FT alone relative to FI alone. Responding under FI FT resulted in response persistence for 2 of 3 participants. Results have implications for the maintenance of desirable behavior, as well as for situations in which FT treatment has been implemented for problem behavior and problem behavior is nevertheless reinforced by caregivers. PMID:21541131

  20. DRO contingencies: an analysis of variable-momentary schedules.

    PubMed

    Lindberg, J S; Iwata, B A; Kahng, S; DeLeon, I G

    1999-01-01

    We conducted several comparative analyses to determine the relative effectiveness of variable-momentary differential-reinforcement-of-other-behavior (VM DRO) schedules. Three individuals who had been diagnosed with mental retardation participated. Results of functional analyses indicated that their self-injurious behavior (SIB) was maintained by social-positive reinforcement. Two individuals participated in a two-stage comparative analysis within multielement and multiple baseline designs. Fixed-interval (FI) and variable-interval (VI) DRO were compared in the first stage; VI DRO and VM DRO were compared in the second. All three schedules effectively reduced the participants' SIB. Treatment for the 3rd individual was conducted in a reversal design to examine the effects of VM DRO when it was implemented in isolation, and results indicated that the procedure was effective in reducing SIB. These findings suggest that VM DRO schedules may represent attractive alternatives to traditional FI schedules because momentary schedules do not require continuous monitoring and may result in higher rates of reinforcement.

  1. Competition between noncontingent and contingent reinforcement schedules during response acquisition.

    PubMed

    Goh, H L; Iwata, B A; DeLeon, I G

    2000-01-01

    We examined the extent to which noncontingent reinforcement (NCR), when used as treatment to reduce problem behavior, might interfere with differential reinforcement contingencies designed to strengthen alternative behavior. After conducting a functional analysis to identify the reinforcers maintaining 2 participants' self-injurious behavior (SIB), we delivered those reinforcers under dense NCR schedules. We delivered the same reinforcers concurrently under differential-reinforcement-of-alternative-behavior (DRA) contingencies in an attempt to strengthen replacement behaviors (mands). Results showed that the NCR plus DRA intervention was associated with a decrease in SIB but little or no increase in appropriate mands. In a subsequent phase, when the NCR schedule was thinned while the DRA schedule remained unchanged, SIB remained low and mands increased. These results suggest that dense NCR schedules may alter establishing operations that result in not only suppression of problem behavior but also interference with the acquisition of appropriate behavior. Thus, the strengthening of socially appropriate behaviors as replacements for problem behavior during NCR interventions might best be achieved if the NCR schedule is first thinned.

  2. SORS: a new software for the simulation of radiotherapy schedule.

    PubMed

    Tamborra, Pasquale; Simeone, Giovanni; Carioggia, Enza

    2010-01-01

    We present a software for choosing the best radiotherapy treatment schedule for head and neck cancers as a beginning radiotherapy plan or a temporarily interrupted plan. Its application occurs according to two modalities: the first adopts the best estimates for model parameters; the second takes into account the parameters' uncertainty too. In both cases, the choice becomes the schedule with the highest uncomplicated tumor control probability (UTCP). In the UTCP valuation, the normal tissue complication probability (NTCP) of each organ is related to the gravity of its possible late injury. For NTCP calculation, it has been adopted the empirical LKB (Lyman-Kutcher-Burman) model corrected for dose/fraction via linear-quadratic model and the incomplete repair effect. The tumor control probability (TCP) model is Poisson based and contains corrections for dose/fraction and regrowth effect; optionally, it can be accounted for the incomplete repair effect as well. At the end of processing, a detailed file with all informations about UTCP, TCP and single organ NTCP is furnished for every examined schedule. Moreover, a useful 3-D graphic representation of the schedule's UTCP is available, allowing the physician to easily understand the schedules with the highest radiotherapeutic efficacy. The open source characteristic allows the program to adapt to the individual clinical case as well as to be a valid support in radiobiological research. 2010 American Association of Medical Dosimetrists. Published by Elsevier Inc. All rights reserved.

  3. Scheduler Design Criteria: Requirements and Considerations

    NASA Technical Reports Server (NTRS)

    Lee, Hanbong

    2016-01-01

    This presentation covers fundamental requirements and considerations for developing schedulers in airport operations. We first introduce performance and functional requirements for airport surface schedulers. Among various optimization problems in airport operations, we focus on airport surface scheduling problem, including runway and taxiway operations. We then describe a basic methodology for airport surface scheduling such as node-link network model and scheduling algorithms previously developed. Next, we explain how to design a mathematical formulation in more details, which consists of objectives, decision variables, and constraints. Lastly, we review other considerations, including optimization tools, computational performance, and performance metrics for evaluation.

  4. A planning language for activity scheduling

    NASA Technical Reports Server (NTRS)

    Zoch, David R.; Lavallee, David; Weinstein, Stuart; Tong, G. Michael

    1991-01-01

    Mission planning and scheduling of spacecraft operations are becoming more complex at NASA. Described here are a mission planning process; a robust, flexible planning language for spacecraft and payload operations; and a software scheduling system that generates schedules based on planning language inputs. The mission planning process often involves many people and organizations. Consequently, a planning language is needed to facilitate communication, to provide a standard interface, and to represent flexible requirements. The software scheduling system interprets the planning language and uses the resource, time duration, constraint, and alternative plan flexibilities to resolve scheduling conflicts.

  5. Testing Task Schedulers on Linux System

    NASA Astrophysics Data System (ADS)

    Jelenković, Leonardo; Groš, Stjepan; Jakobović, Domagoj

    Testing task schedulers on Linux operating system proves to be a challenging task. There are two main problems. The first one is to identify which properties of the scheduler to test. The second problem is how to perform it, e.g., which API to use that is sufficiently precise and in the same time supported on most platforms. This paper discusses the problems in realizing test framework for testing task schedulers and presents one potential solution. Observed behavior of the scheduler is the one used for “normal” task scheduling (SCHED_OTHER), unlike one used for real-time tasks (SCHED_FIFO, SCHED_RR).

  6. Schedule-induced defecation by rats during ratio and interval schedules of food reinforcement.

    PubMed Central

    Wylie, A M; Layng, M P; Meyer, K A

    1993-01-01

    Lever pressing in rats was maintained by continuous and intermittent schedules of food while defecation was monitored. In Experiment 1, reinforcement densities were matched across variable-ratio and variable-interval schedules for three pairs of rats. Defecation occurred in all 3 rats on the variable-ratio schedule and in all 3 rats on the yoked variable-interval schedule. In Experiment 2, fixed-ratio and fixed-interval schedules with similar reinforcement densities maintained lever pressing. Defecation occurred in 3 of 4 rats on the fixed-ratio schedule and in 4 of 4 rats on the fixed-interval schedule. Almost no defecation occurred during continuous reinforcement in either experiment. These results demonstrate that defecation may occur during both ratio and interval schedules and that the inter-reinforcement interval is more important than the behavioral requirements of the schedule in generating schedule-induced defecation. PMID:8283152

  7. A System for Automatically Generating Scheduling Heuristics

    NASA Technical Reports Server (NTRS)

    Morris, Robert

    1996-01-01

    The goal of this research is to improve the performance of automated schedulers by designing and implementing an algorithm by automatically generating heuristics by selecting a schedule. The particular application selected by applying this method solves the problem of scheduling telescope observations, and is called the Associate Principal Astronomer. The input to the APA scheduler is a set of observation requests submitted by one or more astronomers. Each observation request specifies an observation program as well as scheduling constraints and preferences associated with the program. The scheduler employs greedy heuristic search to synthesize a schedule that satisfies all hard constraints of the domain and achieves a good score with respect to soft constraints expressed as an objective function established by an astronomer-user.

  8. Mission and science activity scheduling language

    NASA Technical Reports Server (NTRS)

    Hull, Larry G.

    1993-01-01

    To support the distributed and complex operational scheduling required for future National Aeronautics and Space Administration (NASA) missions, a formal, textual language, the Scheduling Applications Interface Language (SAIL), has been developed. Increased geographic dispersion of investigators is leading to distributed mission and science activity planning, scheduling, and operations. SAIL is an innovation which supports the effective and efficient communication of scheduling information among physically dispersed applications in distributed scheduling environments. SAIL offers a clear, concise, unambiguous expression of scheduling information in a readable, hardware independent format. The language concept, syntax, and semantics incorporate language features found useful during five years of research and prototyping with scheduling languages in physically distributed environments. SAIL allows concise specification of mission and science activity plans in a format which promotes repetition and reuse.

  9. Reactive Scheduling in Multipurpose Batch Plants

    NASA Astrophysics Data System (ADS)

    Narayani, A.; Shaik, Munawar A.

    2010-10-01

    Scheduling is an important operation in process industries for improving resource utilization resulting in direct economic benefits. It has a two-fold objective of fulfilling customer orders within the specified time as well as maximizing the plant profit. Unexpected disturbances such as machine breakdown, arrival of rush orders and cancellation of orders affect the schedule of the plant. Reactive scheduling is generation of a new schedule which has minimum deviation from the original schedule in spite of the occurrence of unexpected events in the plant operation. Recently, Shaik & Floudas (2009) proposed a novel unified model for short-term scheduling of multipurpose batch plants using unit-specific event-based continuous time representation. In this paper, we extend the model of Shaik & Floudas (2009) to handle reactive scheduling.

  10. A System for Automatically Generating Scheduling Heuristics

    NASA Technical Reports Server (NTRS)

    Morris, Robert

    1996-01-01

    The goal of this research is to improve the performance of automated schedulers by designing and implementing an algorithm by automatically generating heuristics by selecting a schedule. The particular application selected by applying this method solves the problem of scheduling telescope observations, and is called the Associate Principal Astronomer. The input to the APA scheduler is a set of observation requests submitted by one or more astronomers. Each observation request specifies an observation program as well as scheduling constraints and preferences associated with the program. The scheduler employs greedy heuristic search to synthesize a schedule that satisfies all hard constraints of the domain and achieves a good score with respect to soft constraints expressed as an objective function established by an astronomer-user.

  11. Scheduling of an aircraft fleet

    NASA Technical Reports Server (NTRS)

    Paltrinieri, Massimo; Momigliano, Alberto; Torquati, Franco

    1992-01-01

    Scheduling is the task of assigning resources to operations. When the resources are mobile vehicles, they describe routes through the served stations. To emphasize such aspect, this problem is usually referred to as the routing problem. In particular, if vehicles are aircraft and stations are airports, the problem is known as aircraft routing. This paper describes the solution to such a problem developed in OMAR (Operative Management of Aircraft Routing), a system implemented by Bull HN for Alitalia. In our approach, aircraft routing is viewed as a Constraint Satisfaction Problem. The solving strategy combines network consistency and tree search techniques.

  12. Scheduling Coast Guard District Cutters

    DTIC Science & Technology

    1992-09-01

    2G, B-2NY, B-2SAR, C); t - week the cutter assumes the patrol status. COSTO - cost of scheduling cutter i to patrol k; ( 1 if ship i is available for...29262a tII 1 ’• l1 1i ,1111’Iii 1 l l H I ,,,,,,,•~II ,, I.,,,.,,_ I 111 ............ ll Unclassified SECURITY CLASSIFICATION OF THIS PAGE REPORT...Postgraduate School (If applicable) Naval Postgraduate School 1 55 6c. ADDRESS (City, State, and ZIP Code) 7b. ADDRESS (City, State, and ZIP Code) Monterey

  13. Schedule effects of noncontingent reinforcement on attention-maintained destructive behavior in identical quadruplets.

    PubMed

    Hagopian, L P; Fisher, W W; Legacy, S M

    1994-01-01

    Noncontingent reinforcement (NCR), a response-independent schedule for the delivery of reinforcement, has been found to be effective in reducing behavior when the reinforcer delivered is responsible for behavioral maintenance. In this study, dense and lean schedules of response-independent attention were compared to determine whether it is necessary to begin with a dense schedule before fading to a lean schedule, or whether treatment would be as effective using a lean schedule at the outset. The subjects were 5-year-old identical quadruplets diagnosed with mental retardation and pervasive developmental disorder who displayed destructive behavior that was maintained by social attention. NCR was selected partially because it is not very labor intensive and could be implemented by a single mother simultaneously with all 4 children. Using a combination multielement and multiple baseline design, it was found that (a) a dense schedule of response-independent reinforcement (i.e., fixed-time 10 s) resulted in immediate and dramatic reductions in destructive behavior with no evidence of an extinction burst, and (b) an equivalent reduction in destructive behavior was achieved with a lean schedule of response-independent reinforcement (fixed-time 5 min) only after a systematic fading procedure was implemented. The findings suggest that the effectiveness of NCR may be dependent on the use of a dense schedule initially, and that systematic fading can increase the effectiveness of a lean schedule.

  14. Schedule effects of noncontingent reinforcement on attention-maintained destructive behavior in identical quadruplets.

    PubMed Central

    Hagopian, L P; Fisher, W W; Legacy, S M

    1994-01-01

    Noncontingent reinforcement (NCR), a response-independent schedule for the delivery of reinforcement, has been found to be effective in reducing behavior when the reinforcer delivered is responsible for behavioral maintenance. In this study, dense and lean schedules of response-independent attention were compared to determine whether it is necessary to begin with a dense schedule before fading to a lean schedule, or whether treatment would be as effective using a lean schedule at the outset. The subjects were 5-year-old identical quadruplets diagnosed with mental retardation and pervasive developmental disorder who displayed destructive behavior that was maintained by social attention. NCR was selected partially because it is not very labor intensive and could be implemented by a single mother simultaneously with all 4 children. Using a combination multielement and multiple baseline design, it was found that (a) a dense schedule of response-independent reinforcement (i.e., fixed-time 10 s) resulted in immediate and dramatic reductions in destructive behavior with no evidence of an extinction burst, and (b) an equivalent reduction in destructive behavior was achieved with a lean schedule of response-independent reinforcement (fixed-time 5 min) only after a systematic fading procedure was implemented. The findings suggest that the effectiveness of NCR may be dependent on the use of a dense schedule initially, and that systematic fading can increase the effectiveness of a lean schedule. PMID:8063630

  15. Environmental surveillance master sampling schedule

    SciTech Connect

    Bisping, L.E.

    1994-02-01

    This document contains the planned 1994 schedules for routine collection of samples for the Surface Environmental Surveillance Project (SESP), Drinking Water Project, and Ground-Water Surveillance Project. Samples are routinely collected for the SESP and analyzed to determine the quality of air, surface water, soil, sediment, wildlife, vegetation, foodstuffs, and farm products at Hanford Site and surrounding communities. The responsibility for monitoring the onsite drinking water falls outside the scope of the SESP. The Hanford Environmental Health Foundation is responsible for monitoring the nonradiological parameters as defined in the National Drinking Water Standards while PNL conducts the radiological monitoring of the onsite drinking water. PNL conducts the drinking water monitoring project concurrent with the SESP to promote efficiency and consistency, utilize the expertise developed over the years, and reduce costs associated with management, procedure development, data management, quality control and reporting. The ground-water sampling schedule identifies ground-water sampling events used by PNL for environmental surveillance of the Hanford Site.

  16. Steps Toward Optimal Competitive Scheduling

    NASA Technical Reports Server (NTRS)

    Frank, Jeremy; Crawford, James; Khatib, Lina; Brafman, Ronen

    2006-01-01

    This paper is concerned with the problem of allocating a unit capacity resource to multiple users within a pre-defined time period. The resource is indivisible, so that at most one user can use it at each time instance. However, different users may use it at different times. The users have independent, se@sh preferences for when and for how long they are allocated this resource. Thus, they value different resource access durations differently, and they value different time slots differently. We seek an optimal allocation schedule for this resource. This problem arises in many institutional settings where, e.g., different departments, agencies, or personal, compete for a single resource. We are particularly motivated by the problem of scheduling NASA's Deep Space Satellite Network (DSN) among different users within NASA. Access to DSN is needed for transmitting data from various space missions to Earth. Each mission has different needs for DSN time, depending on satellite and planetary orbits. Typically, the DSN is over-subscribed, in that not all missions will be allocated as much time as they want. This leads to various inefficiencies - missions spend much time and resource lobbying for their time, often exaggerating their needs. NASA, on the other hand, would like to make optimal use of this resource, ensuring that the good for NASA is maximized. This raises the thorny problem of how to measure the utility to NASA of each allocation. In the typical case, it is difficult for the central agency, NASA in our case, to assess the value of each interval to each user - this is really only known to the users who understand their needs. Thus, our problem is more precisely formulated as follows: find an allocation schedule for the resource that maximizes the sum of users preferences, when the preference values are private information of the users. We bypass this problem by making the assumptions that one can assign money to customers. This assumption is reasonable; a

  17. Schedule optimization study implementation plan

    SciTech Connect

    Not Available

    1993-11-01

    This Implementation Plan is intended to provide a basis for improvements in the conduct of the Environmental Restoration (ER) Program at Hanford. The Plan is based on the findings of the Schedule Optimization Study (SOS) team which was convened for two weeks in September 1992 at the request of the U.S. Department of Energy (DOE) Richland Operations Office (RL). The need for the study arose out of a schedule dispute regarding the submission of the 1100-EM-1 Operable Unit (OU) Remedial Investigation/Feasibility Study (RI/FS) Work Plan. The SOS team was comprised of independent professionals from other federal agencies and the private sector experienced in environmental restoration within the federal system. The objective of the team was to examine reasons for the lengthy RI/FS process and recommend ways to expedite it. The SOS team issued their Final Report in December 1992. The report found the most serious impediments to cleanup relate to a series of management and policy issues which are within the control of the three parties managing and monitoring Hanford -- the DOE, U.S. Environmental Protection Agency (EPA), and the State of Washington Department of Ecology (Ecology). The SOS Report identified the following eight cross-cutting issues as the root of major impediments to the Hanford Site cleanup. Each of these eight issues is quoted from the SOS Report followed by a brief, general description of the proposed approach being developed.

  18. Schedules of controlled substances: rescheduling of hydrocodone combination products from schedule III to schedule II. Final rule.

    PubMed

    2014-08-22

    With the issuance of this final rule, the Administrator of the Drug Enforcement Administration reschedules hydrocodone combination products from schedule III to schedule II of the Controlled Substances Act. This scheduling action is pursuant to the Controlled Substances Act which requires that such actions be made on the record after opportunity for a hearing through formal rulemaking. This action imposes the regulatory controls and administrative, civil, and criminal sanctions applicable to schedule II controlled substances on persons who handle (manufacture, distribute, dispense, import, export, engage in research, conduct instructional activities with, conduct chemical analysis with, or possess) or propose to handle hydrocodone combination products.

  19. Job Scheduling Under the Portable Batch System

    NASA Technical Reports Server (NTRS)

    Henderson, Robert L.; Woodrow, Thomas S. (Technical Monitor)

    1995-01-01

    The typical batch queuing system schedules jobs for execution by a set of queue controls. The controls determine from which queues jobs may be selected. Within the queue, jobs are ordered first-in, first-run. This limits the set of scheduling policies available to a site. The Portable Batch System removes this limitation by providing an external scheduling module. This separate program has full knowledge of the available queued jobs, running jobs, and system resource usage. Sites are able to implement any policy expressible in one of several procedural language. Policies may range from "bet fit" to "fair share" to purely political. Scheduling decisions can be made over the full set of jobs regardless of queue or order. The scheduling policy can be changed to fit a wide variety of computing environments and scheduling goals. This is demonstrated by the use of PBS on an IBM SP-2 system at NASA Ames.

  20. Job Scheduling Under the Portable Batch System

    NASA Technical Reports Server (NTRS)

    Henderson, Robert L.; Woodrow, Thomas S. (Technical Monitor)

    1995-01-01

    The typical batch queuing system schedules jobs for execution by a set of queue controls. The controls determine from which queues jobs may be selected. Within the queue, jobs are ordered first-in, first-run. This limits the set of scheduling policies available to a site. The Portable Batch System removes this limitation by providing an external scheduling module. This separate program has full knowledge of the available queued jobs, running jobs, and system resource usage. Sites are able to implement any policy expressible in one of several procedural language. Policies may range from "bet fit" to "fair share" to purely political. Scheduling decisions can be made over the full set of jobs regardless of queue or order. The scheduling policy can be changed to fit a wide variety of computing environments and scheduling goals. This is demonstrated by the use of PBS on an IBM SP-2 system at NASA Ames.

  1. Minimally disruptive schedule repair for MCM missions

    NASA Astrophysics Data System (ADS)

    Molineaux, Matthew; Auslander, Bryan; Moore, Philip G.; Gupta, Kalyan M.

    2015-05-01

    Mine countermeasures (MCM) missions entail planning and operations in very dynamic and uncertain operating environments, which pose considerable risk to personnel and equipment. Frequent schedule repairs are needed that consider the latest operating conditions to keep mission on target. Presently no decision support tools are available for the challenging task of MCM mission rescheduling. To address this capability gap, we have developed the CARPE system to assist operation planners. CARPE constantly monitors the operational environment for changes and recommends alternative repaired schedules in response. It includes a novel schedule repair algorithm called Case-Based Local Schedule Repair (CLOSR) that automatically repairs broken schedules while satisfying the requirement of minimal operational disruption. It uses a case-based approach to represent repair strategies and apply them to new situations. Evaluation of CLOSR on simulated MCM operations demonstrates the effectiveness of case-based strategy. Schedule repairs are generated rapidly, ensure the elimination of all mines, and achieve required levels of clearance.

  2. A hybrid job-shop scheduling system

    NASA Technical Reports Server (NTRS)

    Hellingrath, Bernd; Robbach, Peter; Bayat-Sarmadi, Fahid; Marx, Andreas

    1992-01-01

    The intention of the scheduling system developed at the Fraunhofer-Institute for Material Flow and Logistics is the support of a scheduler working in a job-shop. Due to the existing requirements for a job-shop scheduling system the usage of flexible knowledge representation and processing techniques is necessary. Within this system the attempt was made to combine the advantages of symbolic AI-techniques with those of neural networks.

  3. Intelligent perturbation algorithms to space scheduling optimization

    NASA Technical Reports Server (NTRS)

    Kurtzman, Clifford R.

    1991-01-01

    The limited availability and high cost of crew time and scarce resources make optimization of space operations critical. Advances in computer technology coupled with new iterative search techniques permit the near optimization of complex scheduling problems that were previously considered computationally intractable. Described here is a class of search techniques called Intelligent Perturbation Algorithms. Several scheduling systems which use these algorithms to optimize the scheduling of space crew, payload, and resource operations are also discussed.

  4. Spent nuclear fuel project integrated schedule plan

    SciTech Connect

    Squires, K.G.

    1995-03-06

    The Spent Nuclear Fuel Integrated Schedule Plan establishes the organizational responsibilities, rules for developing, maintain and status of the SNF integrated schedule, and an implementation plan for the integrated schedule. The mission of the SNFP on the Hanford site is to provide safe, economic, environmentally sound management of Hanford SNF in a manner which stages it to final disposition. This particularly involves K Basin fuel.

  5. Computer-assisted warehouse personnel scheduling

    NASA Astrophysics Data System (ADS)

    Parker, Sandra C.; Malstrom, Eric J.; Usmani, Tariq

    1992-02-01

    A decision support system is developed for personnel scheduling in a multiple warehouse environment. The system incorporates current manpower level, historical data of workers used, empirical load distributions, and performance standards to generate manpower requirements for a specified planning horizon. The software has been developed to be easily adaptable to varying situational details, therefore is widely applicable in different warehouse settings. The system offers personnel managers a valuable tool for evaluating alternative schedules and making intelligent decisions regarding personnel scheduling in warehouses.

  6. Scheduling and SVTs: Rx for Efficiency

    DTIC Science & Technology

    2013-12-01

    to follow in scheduling. In July 2012, the Office of Performance Assessments and An X-47B Unmanned Combat Air System ( UCAS ) demonstrator flies...47B Unmanned Combat Air System ( UCAS ) demonstrator completes an arrested landing on the flight deck of the aircraft carrier USS George H.W. Bush...depends in part on the quality of its schedule. A well-formulated schedule can help Unmanned Combat Air System ( UCAS ) demonstrator launches from the

  7. Scheduling Options Utilized in Departments of Nursing.

    DTIC Science & Technology

    1983-09-01

    or system. Adequate data are not presented concerning design, base- line versus post evaluation , and long term follow-up even though some schedules...summarization and critique of various reported methodologies. Examples of non-traditional scheduling optio~s were described, evaluated for usefulness...services. However, with the present perceived nursing shortage and the dissatisfaction of nurses with con- ventional scheduling methods, a need to evaluate

  8. State Dependent Priority Rules for Scheduling.

    DTIC Science & Technology

    1984-07-01

    jobs have several alternative routings through the shop [30, 54], and the setup costs depend on the sequence of the jobs [7]. The allocation of...scheduling models . A hierarchical planning framework, similar to the concept in closed job shops [32, 34], would allow aggregate planning decisions as...mode, to generate and test schedules for longer time periods, such as weekly or monthly shop schedules and quarterly production

  9. Creating activity schedules using Microsoft Powerpoint.

    PubMed Central

    Rehfeldt, Ruth Anne; Kinney, Elisabeth M; Root, Shannon; Stromer, Robert

    2004-01-01

    We describe how PowerPoint presentation software can be used to create computer activity schedules to teach individuals with special needs. Presented are the steps involved in creating activity schedules with close-ended and open-ended activities, and for preparing schedules that include photos, sounds, text, and videos that can be used to occasion an individual's engagement in a variety of learning activities. PMID:15154226

  10. Creating activity schedules using Microsoft Powerpoint.

    PubMed

    Rehfeldt, Ruth Anne; Kinney, Elisabeth M; Root, Shannon; Stromer, Robert

    2004-01-01

    We describe how PowerPoint presentation software can be used to create computer activity schedules to teach individuals with special needs. Presented are the steps involved in creating activity schedules with close-ended and open-ended activities, and for preparing schedules that include photos, sounds, text, and videos that can be used to occasion an individual's engagement in a variety of learning activities.

  11. 29 CFR 1952.211 - Developmental schedule.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... schedule. (a) Occupational health study accepted and implementation begun July, 1973; (b) Compliance Manual... occupational health program, July, 1975; (m) Fully implemented public employees program, December, 1975; ...

  12. Tool for Merging Proposals Into DSN Schedules

    NASA Technical Reports Server (NTRS)

    Khanampornpan, Teerapat; Kwok, John; Call, Jared

    2008-01-01

    A Practical Extraction and Reporting Language (Perl) script called merge7da has been developed to facilitate determination, by a project scheduler in NASA's Deep Space Network, of whether a proposal for use of the DSN could create a conflict with the current DSN schedule. Prior to the development of merge7da, there was no way to quickly identify potential schedule conflicts: it was necessary to submit a proposal and wait a day or two for a response from a DSN scheduling facility. By using merge7da to detect and eliminate potential schedule conflicts before submitting a proposal, a project scheduler saves time and gains assurance that the proposal will probably be accepted. merge7da accepts two input files, one of which contains the current DSN schedule and is in a DSN-standard format called '7da'. The other input file contains the proposal and is in another DSN-standard format called 'C1/C2'. merge7da processes the two input files to produce a merged 7da-format output file that represents the DSN schedule as it would be if the proposal were to be adopted. This 7da output file can be loaded into various DSN scheduling software tools now in use.

  13. Empowering nurses through an innovative scheduling model.

    PubMed

    Maxson-Cooper, Pamela A

    2011-03-01

    In 1980, Froedtert Hospital opened its doors using an innovative registered nurse scheduling model. The hospital has grown to 500 beds, with over 1,600 registered nurses, and continues to use the 7/70 staffing pattern as a core scheduling model. Registered nurses work a straight seven, 10-hour days, and then have 1 week off, or 26 weeks off a year. For professional registered nurses in acute care, the schedule is predictable and consistent for years. This scheduling pattern has resulted in excellent registered nurse satisfaction, increased retention, and consistency in care delivery teams since 1980.

  14. 40 CFR 52.730 - Compliance schedules.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... supporting information he considers necessary for proper certification. (ii) Any compliance schedule adopted..., 1973. lake county Morton Manufacturing Co Libertyville 205(f) Aug. 27, 1973. la salle county...

  15. Ada task scheduling: A focused Ada investigation

    NASA Technical Reports Server (NTRS)

    Legrand, Sue

    1988-01-01

    The types of control that are important for real time task scheduling are discussed. Some closely related real time issues are mentioned and major committee and research activities in this area are delineated. Although there are some problems with Ada and its real time task scheduling, Ada presents fewer than any known alternative. Ada was designed for the domain of real time embedded systems, but Ada compilers may not contain a level of task scheduling support that is adequate for all real time applications. The question addressed is which implementations of Ada's task scheduling are adequate for effective real time systems for NASA applications.

  16. A customizable, scalable scheduling and reporting system.

    PubMed

    Wood, Jody L; Whitman, Beverly J; Mackley, Lisa A; Armstrong, Robert; Shotto, Robert T

    2014-06-01

    Scheduling is essential for running a facility smoothly and for summarizing activities in use reports. The Penn State Hershey Clinical Simulation Center has developed a scheduling interface that uses off-the-shelf components, with customizations that adapt to each institution's data collection and reporting needs. The system is designed using programs within the Microsoft Office 2010 suite. Outlook provides the scheduling component, while the reporting is performed using Access or Excel. An account with a calendar is created for the main schedule, with separate resource accounts created for each room within the center. The Outlook appointment form's 2 default tabs are used, in addition to a customized third tab. The data are then copied from the calendar into either a database table or a spreadsheet, where the reports are generated.Incorporating this system into an institution-wide structure allows integration of personnel lists and potentially enables all users to check the schedule from their desktop. Outlook also has a Web-based application for viewing the basic schedule from outside the institution, although customized data cannot be accessed. The scheduling and reporting functions have been used for a year at the Penn State Hershey Clinical Simulation Center. The schedule has increased workflow efficiency, improved the quality of recorded information, and provided more accurate reporting. The Penn State Hershey Clinical Simulation Center's scheduling and reporting system can be adapted easily to most simulation centers and can expand and change to meet future growth with little or no expense to the center.

  17. Payload crew training scheduler (PACTS) user's manual

    NASA Technical Reports Server (NTRS)

    Shipman, D. L.

    1980-01-01

    The operation of the payload specialist training scheduler (PACTS) is discussed in this user's manual which is used to schedule payload specialists for mission training on the Spacelab experiments. The PACTS program is a fully automated interactive, computerized scheduling program equipped with tutorial displays. The tutorial displays are sufficiently detailed for use by a program analyst having no computer experience. The PACTS program is designed to operate on the UNIVAC 1108 computer system, and has the capability to load output into a PDP 11/45 Interactive Graphics Display System for printing schedules. The program has the capacity to handle up to three overlapping Spacelab missions.

  18. AVLIS production plant project schedule and milestones

    SciTech Connect

    Not Available

    1984-11-15

    An AVLIS Production Plant Deployment Schedule for the engineering, procurement, and construction for both the Initial Increment of Production and the fully Activated Plant, has been developed by the project team consisting of Lawrence Livermore National Laboratory, Martin Marietta Energy Systems, Inc. with architect-engineer support from Bechtel National, Inc., Stone and Webster Engineering Corporation, and Westinghouse Corporation. The initial deployment phase consists of six separators modules and the three laser power amplifier modules consistent with the FY84 reference design with a name plate capacity of 5 million separative work units/yr followed by a full plant activation to approximately 13 million separative work units/yr. The AVLIS Production Plant project team's strategy for deployment schedule analysis focused on three schedule options: engineering limited schedule; authorization limited schedule; and funding limited project schedule. The three deployment schedule options developed by AVLIS project team have been classified in ranges such as an optimistic, rapid/moderate, or moderate/pessimistic based on the probability of meeting the individual schedule option's major milestones or program objectives of enriching uranium by the AVLIS process in an effective cost and schedule manner. 47 figures, 7 tables.

  19. CASSIUS: The Cassini Uplink Scheduler

    NASA Technical Reports Server (NTRS)

    Bellinger, Earl

    2012-01-01

    The Cassini Uplink Scheduler (CASSIUS) is cross-platform software used to generate a radiation sequence plan for commands being sent to the Cassini spacecraft. Because signals must travel through varying amounts of Earth's atmosphere, several different modes of constant telemetry rates have been devised. These modes guarantee that the spacecraft and the Deep Space Network agree with respect to the data transmission rate. However, the memory readout of a command will be lost if it occurs on a telemetry mode boundary. Given a list of spacecraft message files as well as the available telemetry modes, CASSIUS can find an uplink sequence that ensures safe transmission of each file. In addition, it can predict when the two on-board solid state recorders will swap. CASSIUS prevents data corruption by making sure that commands are not planned for memory readout during telemetry rate changes or a solid state recorder swap.

  20. Environmental surveillance master sampling schedule

    SciTech Connect

    Bisping, L E

    1992-01-01

    Environmental surveillance of the Hanford Site and surrounding areas is conducted by the Pacific Northwest Laboratory (PNL) for the US Department of Energy (DOE). This document contains the planned schedule for routine sample collection for the Surface Environmental Surveillance Project (SESP) and Ground-Water Monitoring Project. Samples for radiological analyses include Air-Particulate Filter, gases and vapor; Water/Columbia River, Onsite Pond, Spring, Irrigation, and Drinking; Foodstuffs/Animal Products including Whole Milk, Poultry and Eggs, and Beef; Foodstuffs/Produce including Leafy Vegetables, Vegetables, and Fruit; Foodstuffs/Farm Products including Wine, Wheat and Alfalfa; Wildlife; Soil; Vegetation; and Sediment. Direct Radiation Measurements include Terrestrial Locations, Columbia River Shoreline Locations, and Onsite Roadway, Railway and Aerial, Radiation Surveys.

  1. Toward Realistic Acquisition Schedule Estimates

    DTIC Science & Technology

    2016-04-30

    qÜáêíÉÉåíÜ=^ååì~ä= ^Åèìáëáíáçå=oÉëÉ~êÅÜ= póãéçëáìã= tÉÇåÉëÇ~ó=pÉëëáçåë= sçäìãÉ=f= = Toward Realistic Acquisition Schedule Estimates Raymond Franck, Professor...the Acquisition Research Program of the Graduate School of Business & Public Policy at the Naval Postgraduate School. To request defense acquisition ...research, to become a research sponsor, or to print additional copies of reports, please contact any of the staff listed on the Acquisition

  2. Metronomic cyclophosphamide schedule-dependence of innate immune cell recruitment and tumor regression in an implanted glioma model

    PubMed Central

    Wu, Junjie; Waxman, David J.

    2014-01-01

    Metronomic cyclophosphamide (CPA) treatment activates robust innate anti-tumor immunity and induces major regression of large, implanted brain tumor xenografts when administered on an intermittent, every 6-day schedule, but not on a daily low-dose or a maximum-tolerated dose CPA schedule. Here, we used an implanted GL261 glioma model to compare five intermittent metronomic CPA schedules to elucidate the kinetics and schedule dependence of innate immune cell recruitment and tumor regression. Tumor-recruited natural killer cells induced by two every 6-day treatment cycles were significantly ablated one day after a third CPA treatment, but largely recovered several days later. Natural killer and other tumor-infiltrating innate immune cells peaked 12 days after the last CPA treatment on the every 6-day schedule, suggesting that drug-free intervals longer than 6 days may show increased efficacy. Metronomic CPA treatments spaced 9 or 12 days apart, or on an alternating 6 and 9 day schedule, induced extensive tumor regression, similar to the 6-day schedule, however, the tumor-infiltrating natural killer cell responses were not sustained, leading to rapid resumption of tumor regrowth after day 24, despite ongoing metronomic CPA treatment. Increasing the CPA dose prolonged the period of tumor regression on the every 9-day schedule, but natural killer cell activation was markedly decreased. Thus, while several intermittent metronomic CPA treatment schedules can activate innate immune cell recruitment leading to major tumor regression, sustained immune and anti-tumor responses are only achieved on the 6-day schedule. However, even with this schedule, some tumors eventually relapse, indicating a need for further improvements in immunogenic metronomic therapies. PMID:25069038

  3. 19 CFR 162.45a - Summary forfeiture of Schedule I and Schedule II controlled substances.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) INSPECTION, SEARCH, AND SEIZURE....S.C. 965. Accordingly, in the case of a seizure of Schedule I or Schedule II controlled substances...

  4. 19 CFR 162.45a - Summary forfeiture of Schedule I and Schedule II controlled substances.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) INSPECTION, SEARCH, AND SEIZURE....S.C. 965. Accordingly, in the case of a seizure of Schedule I or Schedule II controlled substances...

  5. 19 CFR 162.45a - Summary forfeiture of Schedule I and Schedule II controlled substances.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) INSPECTION, SEARCH, AND SEIZURE....S.C. 965. Accordingly, in the case of a seizure of Schedule I or Schedule II controlled substances...

  6. 19 CFR 162.45a - Summary forfeiture of Schedule I and Schedule II controlled substances.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) INSPECTION, SEARCH, AND SEIZURE....S.C. 965. Accordingly, in the case of a seizure of Schedule I or Schedule II controlled substances...

  7. SO/ST/SRG - SCHEDULING PROGRAMS

    NASA Technical Reports Server (NTRS)

    Collazo, F. F.

    1994-01-01

    The Schedule Organizer, SO (COSMIC Program MSC-21525), Schedule Tracker, ST (COSMIC Program MSC-21526), and Report Generator, SRG (COSMIC Program MSC-21527), are programs that manipulate data base files in ways that are advantageous to scheduling applications. Originally designed for the Space Shuttle flight schedule, the program can be easily modified for other scheduling situations. Schedule Organizer provides a simple method for generating distribution lists. These distribution lists contain readers' names for each task schedule defined by the input files. Schedule Organizer contains a primary menu that is displayed at the beginning of the program. The menu provides options as follows: to write input files to an output distribution file, to change a schedule title field and/or distribution list field, to browse through the schedule and input names file for requested schedule numbers, to create an input names file and a schedule titles file, and to delete input schedule titles and associated names. SO provides a choice of two input files. One file holds 25 groups of up to 25 names for each group. The other file holds 25 records. Each 60-character-long record holds a task schedule title or it is a blank entry. SO creates three output files. One holds the formatted list of schedule titles for printout. Another file holds the formatted distribution list for printout. There is one for each input names file schedule group. The third output file holds the schedule title of the last schedule title file deleted by the user. Schedule Tracker provides an effective method for tracking tasks that are "past due" and/or "near term". ST generates reports for each responsible staff member with one or more assigned tasks that fall within the two listed categories. This enables an engineering manager to monitor tasks assigned to staff by running ST on a weekly basis. ST only lists tasks on reports that have become past due or are scheduled for recent completion (near term

  8. SO/ST/SRG - SCHEDULING PROGRAMS

    NASA Technical Reports Server (NTRS)

    Collazo, F. F.

    1994-01-01

    The Schedule Organizer, SO (COSMIC Program MSC-21525), Schedule Tracker, ST (COSMIC Program MSC-21526), and Report Generator, SRG (COSMIC Program MSC-21527), are programs that manipulate data base files in ways that are advantageous to scheduling applications. Originally designed for the Space Shuttle flight schedule, the program can be easily modified for other scheduling situations. Schedule Organizer provides a simple method for generating distribution lists. These distribution lists contain readers' names for each task schedule defined by the input files. Schedule Organizer contains a primary menu that is displayed at the beginning of the program. The menu provides options as follows: to write input files to an output distribution file, to change a schedule title field and/or distribution list field, to browse through the schedule and input names file for requested schedule numbers, to create an input names file and a schedule titles file, and to delete input schedule titles and associated names. SO provides a choice of two input files. One file holds 25 groups of up to 25 names for each group. The other file holds 25 records. Each 60-character-long record holds a task schedule title or it is a blank entry. SO creates three output files. One holds the formatted list of schedule titles for printout. Another file holds the formatted distribution list for printout. There is one for each input names file schedule group. The third output file holds the schedule title of the last schedule title file deleted by the user. Schedule Tracker provides an effective method for tracking tasks that are "past due" and/or "near term". ST generates reports for each responsible staff member with one or more assigned tasks that fall within the two listed categories. This enables an engineering manager to monitor tasks assigned to staff by running ST on a weekly basis. ST only lists tasks on reports that have become past due or are scheduled for recent completion (near term

  9. The effects of schedule of reinforcement on stimulus overselectivity in autistic children.

    PubMed

    Koegel, R L; Schreibman, L; Britten, K; Laitinen, R

    1979-12-01

    Recent research demonstrated that when autistic children are presented a discrimination task with multiple cues, they typically respond to an abnormally limited number, usually one, of the available cues. This phenomenon, termed "stimulus overselectivity," has been implicated as a possible basis for many of the behavioral deficits characteristic of autism. The present investigation was conducted to systemically analyze the effects of changing the schedules of reinforcement during discrimination training on subsequent stimulus overselectivity. Twelve autistic children were taught a discrimination involving multiple visual cues, with a CRF schedule of reinforcement. The children were then overtrained on either the same (CRF) schedule or on a partial (VR:3) reinforcement schedule. Subsequent overselectivity on single-cue test trials was then assessed. Results suggested that significantly less overselectivity occurred when the children were presented with the VR:3 reinforcement schedule during overtraining. These results are discussed in terms of variables influencing overselectivity and in terms of implications for designing treatment procedures for autistic children.

  10. Effects of practice schedules on speech motor learning.

    PubMed

    Wong, Andus W-K; Whitehill, Tara L; Ma, Estella P-M; Masters, Rich

    2013-10-01

    The aim of this study was to evaluate the effects of various practice schedules on learning a novel speech task. Forty healthy Cantonese speakers were asked to learn to produce a Cantonese phrase with two target utterance durations (2500 and 3500 milliseconds). They were randomly assigned to one of four learning conditions, each completing a different practice schedule, namely Blocked only, Random only, Blocked-then-Random, and Random-then-Blocked. Two retention tests (one immediate and one delayed) and a transfer test were administered. The four groups of participants showed different patterns of learning, but achieved comparable levels of performance at the end of the acquisition phase. However, participants in the Blocked only condition were less able to differentiate the two target durations than those in the Random only condition during retention. Furthermore, participants who received both blocked and random practice were less adversely affected by the secondary task during the transfer test than those who received either blocked or random practice alone. These findings suggest that mixed practice schedules are more effective than either blocked or random practice, especially in transferring the acquired speech motor skills to a cognitively demanding situation. The results have clinical implications regarding optimal practice schedules for treatment intervention.

  11. Robust Aircraft Squadron Scheduling in the Face of Absenteeism

    DTIC Science & Technology

    2008-03-01

    manually preparing robust schedules, resistant to changes on paper without any computer help. They try to manually preserve the balance between...But flight schedulers are still assigned to prepare a feasible flight schedule on paper . Schedulers desire to prepare a weekly robust schedule by...the mean of a scheduling model. The desire is for a robust schedule from paper to a computer, thus preparing a robust model will help the

  12. 49 CFR Schedule D to Subpart B of... - Schedule D to Subpart B of Part 1139

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 8 2010-10-01 2010-10-01 false Schedule D to Subpart B of Part 1139 D Schedule D... REVENUE PROCEEDINGS Intercity Bus Industry Pt. 1139, Subpt. B, Sch. D Schedule D to Subpart B of Part 1139... year 19__ (c) Calendar year 19__ (d) Base year actual (e) Part I.—Selected financial data...

  13. 49 CFR Schedule D to Subpart B of... - Schedule D to Subpart B of Part 1139

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 8 2013-10-01 2013-10-01 false Schedule D to Subpart B of Part 1139 D Schedule D... REVENUE PROCEEDINGS Intercity Bus Industry Pt. 1139, Subpt. B, Sch. D Schedule D to Subpart B of Part 1139... year 19__ (c) Calendar year 19__ (d) Base year actual (e) Part I.—Selected financial data...

  14. 49 CFR Schedule D to Subpart B of... - Schedule D to Subpart B of Part 1139

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 8 2014-10-01 2014-10-01 false Schedule D to Subpart B of Part 1139 D Schedule D... REVENUE PROCEEDINGS Intercity Bus Industry Pt. 1139, Subpt. B, Sch. D Schedule D to Subpart B of Part 1139... year 19__ (c) Calendar year 19__ (d) Base year actual (e) Part I.—Selected financial data...

  15. 49 CFR Schedule D to Subpart B of... - Schedule D to Subpart B of Part 1139

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 8 2011-10-01 2011-10-01 false Schedule D to Subpart B of Part 1139 D Schedule D... REVENUE PROCEEDINGS Intercity Bus Industry Pt. 1139, Subpt. B, Sch. D Schedule D to Subpart B of Part 1139... year 19__ (c) Calendar year 19__ (d) Base year actual (e) Part I.—Selected financial data...

  16. 49 CFR Schedule D to Subpart B of... - Schedule D to Subpart B of Part 1139

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 8 2012-10-01 2012-10-01 false Schedule D to Subpart B of Part 1139 D Schedule D... REVENUE PROCEEDINGS Intercity Bus Industry Pt. 1139, Subpt. B, Sch. D Schedule D to Subpart B of Part 1139... year 19__ (c) Calendar year 19__ (d) Base year actual (e) Part I.—Selected financial data...

  17. Actual and Preferred Work Schedules and Scheduling Control as Determinants of Job-Related Attitudes.

    ERIC Educational Resources Information Center

    Krausz, Moshe; Sagie, Abraham; Bidermann, Yehuda

    2000-01-01

    A study of 153 Israeli nurses (84 full time) tested the part-time/full-time dichotomy and a continuous scale of actual work schedules, finding neither significantly related to job satisfaction and commitment. Preferred work schedule and scheduling control were significant determinants of work attitudes. (SK)

  18. Construct Validity of the OASIS Interest Schedule.

    ERIC Educational Resources Information Center

    Parker, Randall M.; Green, Donald

    1987-01-01

    Scores of 135 community college students on the Occupational Aptitude Survey and Interest Schedule (OASIS) were compared with different academic majors. A series of 18 one-way analyses of variance provided evidence for the construct validity of the OASIS Interest Schedule. (Author/GDC)

  19. 29 CFR 1952.361 - Developmental schedule.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... (CONTINUED) APPROVED STATE PLANS FOR ENFORCEMENT OF STATE STANDARDS New Mexico § 1952.361 Developmental schedule. The New Mexico State Plan is developmental. The following is the developmental schedule as... Mexico Occupational Health and Safety Review Commission by January 31, 1976. (d) Enforcement program...

  20. 7 CFR 283.29 - Scheduling conference.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 4 2012-01-01 2012-01-01 false Scheduling conference. 283.29 Section 283.29 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF... personal attendance by the ALJ and the parties or counsel at a scheduling conference is unwarranted or...

  1. 7 CFR 283.29 - Scheduling conference.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 4 2013-01-01 2013-01-01 false Scheduling conference. 283.29 Section 283.29 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF... personal attendance by the ALJ and the parties or counsel at a scheduling conference is unwarranted or...

  2. 7 CFR 283.29 - Scheduling conference.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 4 2014-01-01 2014-01-01 false Scheduling conference. 283.29 Section 283.29 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF... personal attendance by the ALJ and the parties or counsel at a scheduling conference is unwarranted or...

  3. Four-Day Week Schedule. Research Brief

    ERIC Educational Resources Information Center

    Marx, Gary E.

    2007-01-01

    What does research say about the four-day week as an alternative school schedule? More than 100 districts in at least 12 states currently use a four-day week alternative schedule. Most are located in rural areas, serve less than 1000 students, and made the move to a shorter school week with longer instructional days for financial reasons. Although…

  4. Observing the Use of Tactile Schedules

    ERIC Educational Resources Information Center

    Aasen, Gro; Naerland, Terje

    2014-01-01

    This article explores the use of tactile schedules in a heterogeneous sample of children with congenital blindness and varying degrees of additional disabilities. Basic conditions for the use of tactile schedules are proposed and discussed. Child behaviour indicative of some particular functions that can be attained with the use of tactile…

  5. 40 CFR 52.134 - Compliance schedules.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 3 2013-07-01 2013-07-01 false Compliance schedules. 52.134 Section 52.134 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS Arizona § 52.134 Compliance schedules. (a) Federal...

  6. 40 CFR 52.134 - Compliance schedules.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 3 2011-07-01 2011-07-01 false Compliance schedules. 52.134 Section 52.134 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS Arizona § 52.134 Compliance schedules. (a) Federal...

  7. 40 CFR 52.134 - Compliance schedules.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 3 2014-07-01 2014-07-01 false Compliance schedules. 52.134 Section 52.134 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS Arizona § 52.134 Compliance schedules. (a) Federal...

  8. 29 CFR 1952.351 - Developmental schedule.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... (CONTINUED) APPROVED STATE PLANS FOR ENFORCEMENT OF STATE STANDARDS Arizona § 1952.351 Developmental schedule. The Arizona State plan is developmental. The following is the developmental schedule as provided by...) The formulation and approval of inter-agency agreements with the Arizona Atomic Energy Commission, the...

  9. 29 CFR 1952.351 - Developmental schedule.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... (CONTINUED) APPROVED STATE PLANS FOR ENFORCEMENT OF STATE STANDARDS Arizona § 1952.351 Developmental schedule. The Arizona State plan is developmental. The following is the developmental schedule as provided by...) The formulation and approval of inter-agency agreements with the Arizona Atomic Energy Commission, the...

  10. 29 CFR 1952.351 - Developmental schedule.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... (CONTINUED) APPROVED STATE PLANS FOR ENFORCEMENT OF STATE STANDARDS Arizona § 1952.351 Developmental schedule. The Arizona State plan is developmental. The following is the developmental schedule as provided by...) The formulation and approval of inter-agency agreements with the Arizona Atomic Energy Commission, the...

  11. 40 CFR 52.134 - Compliance schedules.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 3 2012-07-01 2012-07-01 false Compliance schedules. 52.134 Section 52.134 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS Arizona § 52.134 Compliance schedules. (a) Federal...

  12. 29 CFR 1952.351 - Developmental schedule.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... (CONTINUED) APPROVED STATE PLANS FOR ENFORCEMENT OF STATE STANDARDS Arizona § 1952.351 Developmental schedule. The Arizona State plan is developmental. The following is the developmental schedule as provided by...) The formulation and approval of inter-agency agreements with the Arizona Atomic Energy Commission, the...

  13. Evolutionary Scheduler for the Deep Space Network

    NASA Technical Reports Server (NTRS)

    Guillaume, Alexandre; Lee, Seungwon; Wang, Yeou-Fang; Zheng, Hua; Chau, Savio; Tung, Yu-Wen; Terrile, Richard J.; Hovden, Robert

    2010-01-01

    A computer program assists human schedulers in satisfying, to the maximum extent possible, competing demands from multiple spacecraft missions for utilization of the transmitting/receiving Earth stations of NASA s Deep Space Network. The program embodies a concept of optimal scheduling to attain multiple objectives in the presence of multiple constraints.

  14. 40 CFR 58.12 - Operating schedules.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...) AMBIENT AIR QUALITY SURVEILLANCE Monitoring Network § 58.12 Operating schedules. State and local... part. Area-specific PAMS operating schedules must be included as part of the PAMS network description... for their area and that are within plus or minus 10 percent of the NAAQS; and all required sites...

  15. 40 CFR 58.12 - Operating schedules.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...) AMBIENT AIR QUALITY SURVEILLANCE Monitoring Network § 58.12 Operating schedules. State and local... part. Area-specific PAMS operating schedules must be included as part of the PAMS network description... regulatory data needs. Required SLAMS stations whose measurements determine the design value for their...

  16. 40 CFR 58.12 - Operating schedules.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...) AMBIENT AIR QUALITY SURVEILLANCE Monitoring Network § 58.12 Operating schedules. State and local... part. Area-specific PAMS operating schedules must be included as part of the PAMS network description... regulatory data needs. Required SLAMS stations whose measurements determine the design value for their...

  17. 6 CFR 27.210 - Submissions schedule.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 6 Domestic Security 1 2010-01-01 2010-01-01 false Submissions schedule. 27.210 Section 27.210 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY CHEMICAL FACILITY ANTI-TERRORISM STANDARDS Chemical Facility Security Program § 27.210 Submissions schedule. (a) Initial Submission....

  18. 6 CFR 27.210 - Submissions schedule.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 6 Domestic Security 1 2014-01-01 2014-01-01 false Submissions schedule. 27.210 Section 27.210 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY CHEMICAL FACILITY ANTI-TERRORISM STANDARDS Chemical Facility Security Program § 27.210 Submissions schedule. (a) Initial Submission....

  19. Improved MLWDF scheduler for LTE downlink transmission

    NASA Astrophysics Data System (ADS)

    Obinna Nnamani, Christantus; Anioke, Chidera Linda; Ikechukwu Ani, Cosmas

    2016-11-01

    In long-term evolution (LTE) downlink transmission, modified least weighted delay first (MLWDF) scheduler is a quality of service (QoS) aware scheduling scheme for real-time (RT) services. Nevertheless, MLWDF performs below optimal among the trade-off between strict delay and loss restraints of RT and non-RT traffic flows, respectively. This is further worsened with the implementation of hybrid automatic retransmission request (HARQ). As these restraints grow unabated with increasing number of user demands, the performance of MLWDF further reduces. In order to ameliorate this situation, there is a need to directly incorporate the variations in user demands and HARQ implementation as parameters to the MLWDF scheduler. In this work, an improvement to the MLWDF scheduler is proposed. The improvement entails adding two novel parameters that characterise user demand and HARQ implementation. The scheduler was tested using varying three classes of service in QoS class identifiers (QCIs) table standardised by Third Generation Partnership Project for LTE network to characterise different services. It was also tested on the basis of packet prioritisation. The proposed scheduler was simulated with LTE-SIM simulator and compared with the MLWDF and proportional fairness schedulers. In terms of delay, throughput and packet loss ratio; the proposed scheduler increased overall system performance.

  20. 40 CFR 52.524 - Compliance schedule.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 3 2014-07-01 2014-07-01 false Compliance schedule. 52.524 Section 52.524 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS Florida § 52.524 Compliance schedule. (a) The information...

  1. 40 CFR 716.60 - Reporting schedule.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Reporting schedule. 716.60 Section 716.60 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT HEALTH AND SAFETY DATA REPORTING General Provisions § 716.60 Reporting schedule. (a) General requirements...

  2. 47 CFR 73.850 - Operating schedule.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 4 2010-10-01 2010-10-01 false Operating schedule. 73.850 Section 73.850 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) BROADCAST RADIO SERVICES RADIO BROADCAST SERVICES Low Power FM Broadcast Stations (LPFM) § 73.850 Operating schedule. (a) All LPFM stations will...

  3. 47 CFR 73.850 - Operating schedule.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 4 2011-10-01 2011-10-01 false Operating schedule. 73.850 Section 73.850 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) BROADCAST RADIO SERVICES RADIO BROADCAST SERVICES Low Power FM Broadcast Stations (LPFM) § 73.850 Operating schedule. (a) All LPFM stations will...

  4. Program For Editing Graphical Displays Of Schedules

    NASA Technical Reports Server (NTRS)

    Mulnix, Cassie L.; Miller, Kevin

    1995-01-01

    XOPPS is window-based software tool from graphics providing easy and fast "what you see is what you get" (WYSIWYG) on-screen editing capabilities. Provides area, analogous to canvas, displaying full image of schedule being edited. Canvas contains header area (for test) and schedule area (for plotting graphical representations of milestone objects in flexible time line). Written in C language.

  5. Incremental Scheduling Engines: Cost Savings through Automation

    NASA Technical Reports Server (NTRS)

    Jaap, John; Phillips, Shaun

    2005-01-01

    As humankind embarks on longer space missions farther from home, the requirements and environments for scheduling the activities performed on these missions are changing. As we begin to prepare for these missions it is appropriate to evaluate the merits and applicability of the different types of scheduling engines. Scheduling engines temporally arrange tasks onto a timeline so that all constraints and ob.jectives are met and resources are not over-booked. Scheduling engines used to schedule space missions fall into three general categories: batch, mixed-initiative, and incremental. This paper, presents an assessment of the engine types, a discussion of the impact of human exploration of the moon and Mars on planning and scheduling, and the applicability of the different types of scheduling engines. This paper will pursue the hypothesis that incremental scheduling engines may have a place in the new environment; they have the potential to reduce cost, to improve the satisfaction of those who execute or benefit from a particular timeline (the customers), and to allow astronauts to plan their own tasks and those of their companion robots.

  6. 40 CFR 52.240 - Compliance schedules.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 3 2013-07-01 2013-07-01 false Compliance schedules. 52.240 Section 52.240 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS California § 52.240 Compliance schedules. (a)...

  7. 44 CFR 72.3 - Fee schedule.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 44 Emergency Management and Assistance 1 2011-10-01 2011-10-01 false Fee schedule. 72.3 Section 72.3 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND... PROCESSING MAP CHANGES § 72.3 Fee schedule. (a) For requests for CLOMRs, LOMRs, and PMRs based on...

  8. Scheduling for deficit irrigation, Crop Yield Predictor

    USDA-ARS?s Scientific Manuscript database

    Irrigators in many countries with dwindling water supplies face the prospect that they will not be able to fully irrigate their crops. In these cases, they still need to schedule their water applications to make the best economic use of available water. Major scheduling questions for deficit irrigat...

  9. 29 CFR 1952.161 - Developmental schedule.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... (CONTINUED) APPROVED STATE PLANS FOR ENFORCEMENT OF STATE STANDARDS Iowa § 1952.161 Developmental schedule. The Iowa State plan is developmental. The following is the developmental schedule as amended and provided by the plan: (a) Enabling legislation becomes effective (Chapter 88 of Iowa Code)—July 1972....

  10. 29 CFR 1952.161 - Developmental schedule.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... (CONTINUED) APPROVED STATE PLANS FOR ENFORCEMENT OF STATE STANDARDS Iowa § 1952.161 Developmental schedule. The Iowa State plan is developmental. The following is the developmental schedule as amended and provided by the plan: (a) Enabling legislation becomes effective (Chapter 88 of Iowa Code)—July 1972....

  11. 29 CFR 1952.161 - Developmental schedule.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... (CONTINUED) APPROVED STATE PLANS FOR ENFORCEMENT OF STATE STANDARDS Iowa § 1952.161 Developmental schedule. The Iowa State plan is developmental. The following is the developmental schedule as amended and provided by the plan: (a) Enabling legislation becomes effective (Chapter 88 of Iowa Code)—July 1972....

  12. 29 CFR 1952.161 - Developmental schedule.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... (CONTINUED) APPROVED STATE PLANS FOR ENFORCEMENT OF STATE STANDARDS Iowa § 1952.161 Developmental schedule. The Iowa State plan is developmental. The following is the developmental schedule as amended and provided by the plan: (a) Enabling legislation becomes effective (Chapter 88 of Iowa Code)—July 1972....

  13. 29 CFR 1952.161 - Developmental schedule.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... (CONTINUED) APPROVED STATE PLANS FOR ENFORCEMENT OF STATE STANDARDS Iowa § 1952.161 Developmental schedule. The Iowa State plan is developmental. The following is the developmental schedule as amended and provided by the plan: (a) Enabling legislation becomes effective (Chapter 88 of Iowa Code)—July 1972....

  14. 5 CFR 838.132 - Payment schedules.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... (CONTINUED) COURT ORDERS AFFECTING RETIREMENT BENEFITS Court Orders Generally Procedures Applicable to All Court Orders § 838.132 Payment schedules. (a) Under CSRS and FERS, employee annuities and survivor... accrues. (b) In honoring and complying with a court order, OPM will not disrupt the payment schedule...

  15. 5 CFR 838.132 - Payment schedules.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... (CONTINUED) COURT ORDERS AFFECTING RETIREMENT BENEFITS Court Orders Generally Procedures Applicable to All Court Orders § 838.132 Payment schedules. (a) Under CSRS and FERS, employee annuities and survivor... accrues. (b) In honoring and complying with a court order, OPM will not disrupt the payment schedule...

  16. 5 CFR 838.132 - Payment schedules.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... (CONTINUED) COURT ORDERS AFFECTING RETIREMENT BENEFITS Court Orders Generally Procedures Applicable to All Court Orders § 838.132 Payment schedules. (a) Under CSRS and FERS, employee annuities and survivor... accrues. (b) In honoring and complying with a court order, OPM will not disrupt the payment schedule...

  17. 5 CFR 838.132 - Payment schedules.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... (CONTINUED) COURT ORDERS AFFECTING RETIREMENT BENEFITS Court Orders Generally Procedures Applicable to All Court Orders § 838.132 Payment schedules. (a) Under CSRS and FERS, employee annuities and survivor... accrues. (b) In honoring and complying with a court order, OPM will not disrupt the payment schedule...

  18. 5 CFR 838.132 - Payment schedules.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... (CONTINUED) COURT ORDERS AFFECTING RETIREMENT BENEFITS Court Orders Generally Procedures Applicable to All Court Orders § 838.132 Payment schedules. (a) Under CSRS and FERS, employee annuities and survivor... accrues. (b) In honoring and complying with a court order, OPM will not disrupt the payment schedule...

  19. 40 CFR 52.626 - Compliance schedules.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 3 2011-07-01 2011-07-01 false Compliance schedules. 52.626 Section 52.626 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS Hawaii § 52.626 Compliance schedules. (a) (b) The...

  20. 29 CFR 1952.311 - Developmental schedule.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 9 2012-07-01 2012-07-01 false Developmental schedule. 1952.311 Section 1952.311 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR (CONTINUED) APPROVED STATE PLANS FOR ENFORCEMENT OF STATE STANDARDS Hawaii § 1952.311 Developmental schedule...

  1. 40 CFR 52.626 - Compliance schedules.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 3 2013-07-01 2013-07-01 false Compliance schedules. 52.626 Section 52.626 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS Hawaii § 52.626 Compliance schedules. (a) (b) The...

  2. 29 CFR 1952.311 - Developmental schedule.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 9 2013-07-01 2013-07-01 false Developmental schedule. 1952.311 Section 1952.311 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR (CONTINUED) APPROVED STATE PLANS FOR ENFORCEMENT OF STATE STANDARDS Hawaii § 1952.311 Developmental schedule...

  3. 40 CFR 52.626 - Compliance schedules.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 3 2012-07-01 2012-07-01 false Compliance schedules. 52.626 Section 52.626 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS Hawaii § 52.626 Compliance schedules. (a) (b) The...

  4. 29 CFR 1952.311 - Developmental schedule.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 9 2014-07-01 2014-07-01 false Developmental schedule. 1952.311 Section 1952.311 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR (CONTINUED) APPROVED STATE PLANS FOR ENFORCEMENT OF STATE STANDARDS Hawaii § 1952.311 Developmental schedule...

  5. 40 CFR 52.626 - Compliance schedules.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 3 2010-07-01 2010-07-01 false Compliance schedules. 52.626 Section 52.626 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS Hawaii § 52.626 Compliance schedules. (a) (b) The...

  6. 40 CFR 52.626 - Compliance schedules.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 3 2014-07-01 2014-07-01 false Compliance schedules. 52.626 Section 52.626 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS Hawaii § 52.626 Compliance schedules. (a) (b) The...

  7. 49 CFR 665.21 - Scheduling.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... TRANSPORTATION BUS TESTING Operations § 665.21 Scheduling. (a) To schedule a bus for testing, a manufacturer shall contact the operator of FTA's bus testing program. Contact information and procedures are available on the operator's bus testing Web site, http://www.altoonabustest.com. (b) Upon contacting...

  8. 49 CFR 665.21 - Scheduling.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... TRANSPORTATION BUS TESTING Operations § 665.21 Scheduling. (a) To schedule a bus for testing, a manufacturer shall contact the operator of FTA's bus testing program. Contact information and procedures are available on the operator's bus testing Web site, http://www.altoonabustest.com. (b) Upon contacting...

  9. 49 CFR 665.21 - Scheduling.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... TRANSPORTATION BUS TESTING Operations § 665.21 Scheduling. (a) To schedule a bus for testing, a manufacturer shall contact the operator of FTA's bus testing program. Contact information and procedures are available on the operator's bus testing Web site, http://www.altoonabustest.com. (b) Upon contacting...

  10. 49 CFR 665.21 - Scheduling.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... TRANSPORTATION BUS TESTING Operations § 665.21 Scheduling. (a) To schedule a bus for testing, a manufacturer shall contact the operator of FTA's bus testing program. Contact information and procedures are available on the operator's bus testing Web site, http://www.altoonabustest.com. (b) Upon contacting...

  11. 49 CFR 665.21 - Scheduling.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... TRANSPORTATION BUS TESTING Operations § 665.21 Scheduling. (a) To schedule a bus for testing, a manufacturer shall contact the operator of FTA's bus testing program. Contact information and procedures are available on the operator's bus testing Web site, http://www.altoonabustest.com. (b) Upon contacting...

  12. 40 CFR 716.60 - Reporting schedule.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 31 2011-07-01 2011-07-01 false Reporting schedule. 716.60 Section 716.60 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT HEALTH AND SAFETY DATA REPORTING General Provisions § 716.60 Reporting schedule. (a) General...

  13. 44 CFR 72.3 - Fee schedule.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 44 Emergency Management and Assistance 1 2013-10-01 2013-10-01 false Fee schedule. 72.3 Section 72.3 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND... PROCESSING MAP CHANGES § 72.3 Fee schedule. (a) For requests for CLOMRs, LOMRs, and PMRs based on structural...

  14. 44 CFR 72.3 - Fee schedule.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 44 Emergency Management and Assistance 1 2014-10-01 2014-10-01 false Fee schedule. 72.3 Section 72.3 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND... PROCESSING MAP CHANGES § 72.3 Fee schedule. (a) For requests for CLOMRs, LOMRs, and PMRs based on structural...

  15. 44 CFR 72.3 - Fee schedule.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 44 Emergency Management and Assistance 1 2012-10-01 2011-10-01 true Fee schedule. 72.3 Section 72.3 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND... PROCESSING MAP CHANGES § 72.3 Fee schedule. (a) For requests for CLOMRs, LOMRs, and PMRs based on structural...

  16. 40 CFR 52.1175 - Compliance schedules.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... have not been submitted for every source for which they are required. (d) Federal compliance schedules. (1) Except as provided in paragraph (d)(3) of this section, the owner or operator of any stationary... schedule, whether or not the increment has been met. (3)(i) Paragraphs (d) (1) and (2) of this section...

  17. 15 CFR 700.14 - Preferential scheduling.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 15 Commerce and Foreign Trade 2 2011-01-01 2011-01-01 false Preferential scheduling. 700.14 Section 700.14 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued... DEFENSE PRIORITIES AND ALLOCATIONS SYSTEM Industrial Priorities § 700.14 Preferential scheduling. (a) A...

  18. 15 CFR 700.14 - Preferential scheduling.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 15 Commerce and Foreign Trade 2 2010-01-01 2010-01-01 false Preferential scheduling. 700.14 Section 700.14 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued... DEFENSE PRIORITIES AND ALLOCATIONS SYSTEM Industrial Priorities § 700.14 Preferential scheduling. (a) A...

  19. 46 CFR 308.503 - Rate schedules.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Cargo Insurance I-Introduction § 308.503 Rate schedules. Rate schedules published by the Maritime... Maritime Administrator at any time without notice. If no rate is published for a voyage on which war...

  20. Observing the Use of Tactile Schedules

    ERIC Educational Resources Information Center

    Aasen, Gro; Naerland, Terje

    2014-01-01

    This article explores the use of tactile schedules in a heterogeneous sample of children with congenital blindness and varying degrees of additional disabilities. Basic conditions for the use of tactile schedules are proposed and discussed. Child behaviour indicative of some particular functions that can be attained with the use of tactile…

  1. 10 CFR 51.15 - Time schedules.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Time schedules. 51.15 Section 51.15 Energy NUCLEAR... REGULATORY FUNCTIONS National Environmental Policy Act-Regulations Implementing Section 102(2) § 51.15 Time... proposed action or a petitioner for rulemaking shall, establish a time schedule for all or any constituent...

  2. 10 CFR 51.15 - Time schedules.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false Time schedules. 51.15 Section 51.15 Energy NUCLEAR... REGULATORY FUNCTIONS National Environmental Policy Act-Regulations Implementing Section 102(2) § 51.15 Time... proposed action or a petitioner for rulemaking shall, establish a time schedule for all or any constituent...

  3. 33 CFR 242.6 - Fee schedule.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... MANAGEMENT SERVICES PROGRAM ESTABLISHMENT OF FEES FOR COST RECOVERY § 242.6 Fee schedule. (a) General. The... Services requiring more than ten minutes and up to one work day to provide. The Fee Schedule has been... total costs for services provided to Federal agencies and private persons. (b) Level of effort....

  4. 10 CFR 51.15 - Time schedules.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false Time schedules. 51.15 Section 51.15 Energy NUCLEAR... REGULATORY FUNCTIONS National Environmental Policy Act-Regulations Implementing Section 102(2) § 51.15 Time... proposed action or a petitioner for rulemaking shall, establish a time schedule for all or any constituent...

  5. 10 CFR 51.15 - Time schedules.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 2 2012-01-01 2012-01-01 false Time schedules. 51.15 Section 51.15 Energy NUCLEAR... REGULATORY FUNCTIONS National Environmental Policy Act-Regulations Implementing Section 102(2) § 51.15 Time... proposed action or a petitioner for rulemaking shall, establish a time schedule for all or any constituent...

  6. 10 CFR 51.15 - Time schedules.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 2 2013-01-01 2013-01-01 false Time schedules. 51.15 Section 51.15 Energy NUCLEAR... REGULATORY FUNCTIONS National Environmental Policy Act-Regulations Implementing Section 102(2) § 51.15 Time... proposed action or a petitioner for rulemaking shall, establish a time schedule for all or any constituent...

  7. 46 CFR 525.2 - Terminal schedules.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... MARITIME COMMISSION REGULATIONS AFFECTING OCEAN SHIPPING IN FOREIGN COMMERCE MARINE TERMINAL OPERATOR... their own negligence, or that impose upon others the obligation to indemnify or hold-harmless the terminals from liability for their own negligence. (2) Enforcement of terminal schedules. Any schedule...

  8. 46 CFR 525.2 - Terminal schedules.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... MARITIME COMMISSION REGULATIONS AFFECTING OCEAN SHIPPING IN FOREIGN COMMERCE MARINE TERMINAL OPERATOR... their own negligence, or that impose upon others the obligation to indemnify or hold-harmless the terminals from liability for their own negligence. (2) Enforcement of terminal schedules. Any schedule...

  9. 46 CFR 525.2 - Terminal schedules.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... MARITIME COMMISSION REGULATIONS AFFECTING OCEAN SHIPPING IN FOREIGN COMMERCE MARINE TERMINAL OPERATOR... their own negligence, or that impose upon others the obligation to indemnify or hold-harmless the terminals from liability for their own negligence. (2) Enforcement of terminal schedules. Any schedule...

  10. 46 CFR 525.2 - Terminal schedules.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... MARITIME COMMISSION REGULATIONS AFFECTING OCEAN SHIPPING IN FOREIGN COMMERCE MARINE TERMINAL OPERATOR... their own negligence, or that impose upon others the obligation to indemnify or hold-harmless the terminals from liability for their own negligence. (2) Enforcement of terminal schedules. Any schedule...

  11. 37 CFR 2.85 - Classification schedules.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2012-07-01 2012-07-01 false Classification schedules. 2..., DEPARTMENT OF COMMERCE RULES OF PRACTICE IN TRADEMARK CASES Classification § 2.85 Classification schedules. (a) International classification system. Section 6.1 of this chapter sets forth the international...

  12. 37 CFR 2.85 - Classification schedules.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2013-07-01 2013-07-01 false Classification schedules. 2..., DEPARTMENT OF COMMERCE RULES OF PRACTICE IN TRADEMARK CASES Classification § 2.85 Classification schedules. (a) International classification system. Section 6.1 of this chapter sets forth the international...

  13. 37 CFR 2.85 - Classification schedules.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2014-07-01 2014-07-01 false Classification schedules. 2..., DEPARTMENT OF COMMERCE RULES OF PRACTICE IN TRADEMARK CASES Classification § 2.85 Classification schedules. (a) International classification system. Section 6.1 of this chapter sets forth the international...

  14. Soil water monitoring equipment for irrigation scheduling

    USDA-ARS?s Scientific Manuscript database

    Equipment for monitoring soil water content and sometimes bulk electrical conductivity can be used for scheduling irrigations if the accuracy of the equipment is sufficient to avoid damanging plants and wasting water and fertilizer. Irrigation scheduling is the process of deciding when to irrigate a...

  15. 37 CFR 2.85 - Classification schedules.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Classification schedules. 2..., DEPARTMENT OF COMMERCE RULES OF PRACTICE IN TRADEMARK CASES Classification § 2.85 Classification schedules. (a) International classification system. Section 6.1 of this chapter sets forth the international...

  16. Patient Scheduling with a Personal Touch

    PubMed Central

    Durst, Stephen

    1989-01-01

    What once required extensive manual effort and coordination has been reduced to a single access point for patient data collection and scheduling. Over half of the one million patients seen yearly by a large multi-specialty physicians' group are handled with an automated scheduling system with patient sensitivity as the main priority.

  17. 11 CFR 9006.3 - Alphabetized schedules.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 11 Federal Elections 1 2010-01-01 2010-01-01 false Alphabetized schedules. 9006.3 Section 9006.3 Federal Elections FEDERAL ELECTION COMMISSION PRESIDENTIAL ELECTION CAMPAIGN FUND: GENERAL ELECTION FINANCING REPORTS AND RECORDKEEPING § 9006.3 Alphabetized schedules. If the authorized committee(s) of...

  18. Management Matters. Changing to Flexible Scheduling

    ERIC Educational Resources Information Center

    Pappas, Marjorie L.

    2005-01-01

    Elementary school library media specialists state that one of the most frustrating issues they face is the fixed schedules in their library media centers. Beyond the cost effectiveness issue, the fixed schedule severely limits using the resources of the library media center for inquiry learning and collaborative teaching experiences between the…

  19. 40 CFR 63.1291 - Compliance schedule.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... for Hazardous Air Pollutants for Flexible Polyurethane Foam Production § 63.1291 Compliance schedule... 40 Protection of Environment 11 2010-07-01 2010-07-01 true Compliance schedule. 63.1291 Section 63.1291 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED...

  20. Program For Editing Graphical Displays Of Schedules

    NASA Technical Reports Server (NTRS)

    Mulnix, Cassie L.; Miller, Kevin

    1995-01-01

    XOPPS is window-based software tool from graphics providing easy and fast "what you see is what you get" (WYSIWYG) on-screen editing capabilities. Provides area, analogous to canvas, displaying full image of schedule being edited. Canvas contains header area (for test) and schedule area (for plotting graphical representations of milestone objects in flexible time line). Written in C language.