Sample records for chronomodulated treatment schedules

  1. Chronomodulation of topotecan or X-radiation treatment increases treatment efficacy without enhancing acute toxicity.

    PubMed

    Mullins, Dana; Proulx, Denise; Saoudi, A; Ng, Cheng E

    2005-05-01

    Topotecan (TPT), a camptothecin analog, is currently used to treat human ovarian and small-cell lung cancer and is in clinical trials for other tumor sites. However, it is unknown whether chronomodulation of TPT treatment is beneficial. We examined the effects of administering TPT or X-radiation (XR) alone at different times of the day or night. We treated mice bearing human colorectal tumor xenografts at four different times representing the early rest period (9 am or 3 HALO [hours after light onset]), late rest period (3 pm or 9 HALO), early active period (9 pm or 15 HALO), and late active period (3 am or 21 HALO) of the mice. We gave either TPT (12 mg/kg, injected i.p.) or XR (4 Gy, directed to the tumor) twice weekly on Days 0, 4, 7, 10 within 2 weeks. Treatment with either TPT or XR at 3 am demonstrated the greatest efficacy (measured by a tumor regrowth assay) without significantly increasing acute toxicity (assessed by a decrease in leukocyte counts or body weight). Conversely, treatment at 3 pm, in particular, showed increased toxicity without any enhanced efficacy. Our study provided the first evidence that chronomodulation of TPT treatments, consistent with the findings of other camptothecin analogs, is potentially clinically beneficial. Additionally, our findings suggest that chronomodulation of fractionated XR treatments is also potentially clinically beneficial.

  2. Clinical experience with chronomodulated infusional 5-fluorouracil chemoradiotherapy for pancreatic adenocarcinoma

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Keene, Kimberly S.; Rich, Tyvin A.; Penberthy, David R.

    2005-05-01

    Purpose: To evaluate retrospectively the efficacy and chronic toxicities of concurrent radiotherapy and chronomodulated infusion 5-fluorouracil (5-FU) in patients with pancreatic adenocarcinoma. Methods and Materials: Twenty-eight patients with pancreatic adenocarcinoma were treated between January 1997 and May 2000 with 5-FU chronomodulated chemoradiotherapy. Chronomodulated delivery of chemotherapy was chosen on the basis of a lower toxicity profile in the treatment of GI malignancies. The median age was 64 years. Of the 28 patients, 12 were men and 16 were women. Eight patients had unresectable disease and 20 were treated after pancreatic resection. The median radiation dose was 50.4 Gy given inmore » 28 fractions. The median field length and width was 10.6 cm and 10.9 cm, respectively. Concurrent chemotherapy with 5-FU was administered 5 d/wk, with a median total dose of 8.4 g/m{sup 2} (300 mg/m{sup 2}/d). Chronomodulated 5-FU delivery consisted of a low basal infusion for 16 h followed by an 8-h escalating-deescalating infusion peaking at 10 PM. Survival and recurrence data were evaluated using Kaplan-Meier actuarial analysis. Toxicities were recorded using the Radiation Therapy Oncology Group grading system. Results: The median follow-up for all patients was 26 months (range, 4-68 months). The median overall survival for the 20 patients treated postoperatively was 34 months, with a 3- and 5-year actuarial survival rate of 40% and 21%, respectively. If the 3 patients with carcinoma of the ampulla were removed from the data set, the mean overall survival in the resected patients was 34 months, with a 3-year and 5-year actuarial survival rate of 40% and 17%, respectively. The 8 unresectable patients had a median overall survival of 14 months, and none lived past 2 years. No patient experienced Grade 3 or 4 hematologic toxicity or weight loss. Five patients had nausea and dehydration requiring i.v. fluids; only one (4%) was hospitalized. Four patients required

  3. Chronomodulated drug delivery system of urapidil for the treatment of hypertension

    PubMed Central

    Chaudhary, Sona S.; Patel, Hetal K.; Parejiya, Punit B.; Shelat, Pragna K.

    2015-01-01

    Introduction: Hypertension is a disease which shows circadian rhythm in the pattern of two peaks, one in the evening at about 7pm and other in the early morning between 4 am to 8 am. Conventional therapies are incapable to target those time points when actually the symptoms get worsened. To achieve drug release at two time points, chronomodulated delivery system may offer greater benefits. Materials and methods: The chronomodulated system comprised of dual approach; immediate release granules (IRG) and pulsatile release mini-tablets (PRM) filled in the hard gelatin capsule. The mini-tablets were coated using Eudragit S-100 which provided the lag time. To achieve the desired release, various parameters like coating duration and coat thickness were studied. The immediate release granules were evaluated for micromeritical properties and drug release, while mini-tablets were evaluated for various parameters such as hardness, thickness, friability, weight variation, drug content, and disintegration time and in-vitro drug release. Compatibility of drug-excipient was checked by fourier transform infrared spectroscopy and Differential scanning calorimetry studies and pellets morphology was done by Scanning electron microscopy studies. Results: The in-vitro release profile suggested that immediate release granules gives drug release within 20 min at the time of evening attack while the programmed pulsatile release was achieved from coated mini-tablets after a lag time of 9hrs, which was consistent with the demand of drug during early morning hour attack. Pellets found to be spherical in shape with smooth surface. Moreover compatibility studies illustrated no deleterious reaction between drug and polymers used in the study. Conclusions: The dual approach of developed chronomodulated formulation found to be satisfactory in the treatment of hypertension. PMID:25838996

  4. Synergistic Effect of Combination Topotecan and Chronomodulated Radiation Therapy on Xenografted Human Nasopharyngeal Carcinoma

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Zhang, YanLing; Chen, Xin; Ren, PeiRong

    2013-10-01

    Purpose: To investigate the in vivo chronomodulated radiosensitizing effect of topotecan (TPT) on human nasopharyngeal carcinoma (NPC) and its possible mechanisms. Methods and Materials: Xenografted BALB/c (nu/nu) NPC mice were synchronized with an alternation of 12 hours of light from 0 to 12 hours after light onset (HALO) and 12 hours of darkness to establish a unified biological rhythm. Chronomodulated radiosensitization of TPT was investigated by analysis of tumor regrowth delay (TGD), pimonidazole hydrochloride, histone H2AX phosphorylation, (γ-H2AX) topoisomerase I (Top I), cell cycle, and apoptosis after treatment with (1) TPT (10 mg/kg) alone; (2) radiation therapy alone (RT); andmore » (3) TPT+RT at 3, 9, 15, and 21 HALO. The tumor-loaded mice without any treatment were used as controls. Results: The TPT+RT combination was more effective than TPT or RT as single agents. The TPT+RT combination at 15 HALO was best (TGD = 58.0 ± 3.6 days), and TPT+RT at 3 HALO was worst (TGD = 35.0 ± 1.5 days) among the 4 TPT+RT groups (P<.05). Immunohistochemistry analysis revealed a significantly increased histone H2AX phosphorylation expression and decreased pimonidazole hydrochloride expression in the TPT+RT group at the same time point. The results suggested that the level of tumor hypoxia and DNA damage varied in a time-dependent manner. The expression of Top I in the TPT+RT group was also significantly different from the control tumors at 15 HALO (P<.05). Cell apoptosis index was increased and the proportion of cells in S phase was decreased (P<.05) with the highest value in 15 HALO and the lowest in 3 HALO. Conclusions: This study suggested that TPT combined with chronoradiotherapy could enhance the radiosensitivity of xenografted NPC. The TPT+RT group at 15 HALO had the best therapeutic effect. The chronomodulated radiosensitization mechanisms of TPT might be related to circadian rhythm of tumor hypoxia, cell cycle redistribution, DNA damage, and expression of

  5. 7 CFR 305.10 - Treatment schedules for combination treatments.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 5 2010-01-01 2010-01-01 false Treatment schedules for combination treatments. 305.10... HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE PHYTOSANITARY TREATMENTS Chemical Treatments § 305.10 Treatment schedules for combination treatments. (a) Fumigation followed by cold treatment. (1...

  6. Does chronomodulated radiotherapy improve pathological response in locally advanced rectal cancer?

    PubMed

    Squire, Tim; Buchanan, Grant; Rangiah, David; Davis, Ian; Yip, Desmond; Chua, Yu Jo; Rich, Tyvin; Elsaleh, Hany

    2017-01-01

    The predominant mode of radiation-induced cell death for solid tumours is mitotic catastrophe, which is in part dependent on sublethal damage repair being complete at around 6 h. Circadian variation appears to play a role in normal cellular division, and this could influence tumour response of radiation treatment depending on the time of treatment delivery. We tested the hypothesis that radiation treatment later in the day may improve tumour response and nodal downstaging in rectal cancer patients treated neoadjuvantly with radiation therapy. Recruitment was by retrospective review of 267 rectal cancer patients treated neoadjuvantly in the Department of Radiation Oncology at the Canberra Hospital between January 2010 and November 2015. One hundred and fifty-five patients met the inclusion criteria for which demographic, pathological and imaging data were collected, as well as the time of day patients received treatment with each fraction of radiotherapy. Data analysis was performed using the Statistical Package R with nonparametric methods of significance for all tests set at p < 0.05. Of the 45 female and 110 male patients, the median age was 64. Seventy-three percent had cT3 disease and there was a mean tumour distance from the anal verge of 7 cm. Time to surgical resection following radiotherapy ranged from 4 to 162 days with a median of 50 days, with a complete pathological response seen in 21% of patients. Patients exhibiting a favourable pathological response had smaller median pre- and postradiotherapy tumour size and had a greater change in tumour size following treatment (p < 0.01). Patients who received the majority of their radiotherapy fractions after 12:00 pm were more likely to show a complete or moderate pathological response (p = 0.035) and improved nodal downstaging. There were also more favourable responses amongst patients with longer time to surgical resection postradiotherapy (p < 0.004), although no relationship was seen between response and

  7. 7 CFR 305.16 - Cold treatment schedules.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 5 2010-01-01 2010-01-01 false Cold treatment schedules. 305.16 Section 305.16... SERVICE, DEPARTMENT OF AGRICULTURE PHYTOSANITARY TREATMENTS Cold Treatments § 305.16 Cold treatment schedules. Treatment schedule Temperature ( °F) Exposure period T107-a 1 34 or below 14 days. 35 or below 16...

  8. 7 CFR 305.23 - Steam sterilization treatment schedules.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 5 2010-01-01 2010-01-01 false Steam sterilization treatment schedules. 305.23... HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE PHYTOSANITARY TREATMENTS Heat Treatments § 305.23 Steam sterilization treatment schedules. Treatment schedule Temperature( °F) Pressure Exposure period...

  9. 7 CFR 305.8 - Sulfuryl fluoride treatment schedules.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 5 2010-01-01 2010-01-01 false Sulfuryl fluoride treatment schedules. 305.8 Section 305.8 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH... fluoride treatment schedules. Treatment schedule Pressure Temperature ( °F) Dosage rate(lb/1000 cubic feet...

  10. 7 CFR 305.42 - Miscellaneous treatment schedules.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 5 2010-01-01 2010-01-01 false Miscellaneous treatment schedules. 305.42 Section 305... INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE PHYTOSANITARY TREATMENTS Miscellaneous Treatments § 305.42 Miscellaneous treatment schedules. (a) T102-b, T102-b-1, T102-b-2, soapy water and wax. (1) The fruit must be...

  11. 7 CFR 305.28 - Kiln sterilization treatment schedule.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 5 2010-01-01 2010-01-01 false Kiln sterilization treatment schedule. 305.28 Section... INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE PHYTOSANITARY TREATMENTS Heat Treatments § 305.28 Kiln sterilization treatment schedule. T404-b-4 Dry bulb temperature( °F) Wet bulb depression( °F) Percent...

  12. 7 CFR 305.18 - Quick freeze treatment schedule.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 5 2010-01-01 2010-01-01 false Quick freeze treatment schedule. 305.18 Section 305.18... SERVICE, DEPARTMENT OF AGRICULTURE PHYTOSANITARY TREATMENTS Quick Freeze Treatments § 305.18 Quick freeze treatment schedule. (a) T110. (1) Initially, lower the commodity's temperature to 0 °F or below. (2) Hold...

  13. 75 FR 4227 - Phytosanitary Treatments; Location of and Process for Updating Treatment Schedules

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-26

    ...We are amending the phytosanitary treatment regulations in 7 CFR part 305 by removing the lists of approved treatments and treatment schedules from the regulations, while retaining the general requirements for performing treatments and certifying or approving treatment facilities. We are removing treatment schedules from other places where they are currently found in 7 CFR chapter III as well. Approved treatment schedules will instead be found in the Plant Protection and Quarantine Treatment Manual, which is available on the Internet. We are also establishing a new process to provide the public with notice and the opportunity to comment on changes to treatment schedules. Finally, we are harmonizing and combining the requirements for performing irradiation treatment for imported articles, articles moved interstate from Hawaii and U.S. territories, and articles moved interstate from an area quarantined for fruit flies. These changes will simplify and expedite our processes for adding, changing, and removing treatment schedules while continuing to provide for public participation in the process. These changes will also simplify our presentation of treatments to the public by consolidating all treatments into one document and eliminating redundant text from the regulations.

  14. 7 CFR 305.29 - Vacuum heat treatment schedule.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 5 2010-01-01 2010-01-01 false Vacuum heat treatment schedule. 305.29 Section 305.29... SERVICE, DEPARTMENT OF AGRICULTURE PHYTOSANITARY TREATMENTS Heat Treatments § 305.29 Vacuum heat treatment... vacuum at 8 hours. Maintain the vacuum until the end of the treatment. Gradually increase the temperature...

  15. 7 CFR 305.22 - Hot water immersion treatment schedules.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 5 2010-01-01 2010-01-01 false Hot water immersion treatment schedules. 305.22 Section 305.22 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE PHYTOSANITARY TREATMENTS Heat Treatments § 305.22...

  16. Phase I Design for Completely or Partially Ordered Treatment Schedules

    PubMed Central

    Wages, Nolan A.; O’Quigley, John; Conaway, Mark R.

    2013-01-01

    The majority of methods for the design of Phase I trials in oncology are based upon a single course of therapy, yet in actual practice it may be the case that there is more than one treatment schedule for any given dose. Therefore, the probability of observing a dose-limiting toxicity (DLT) may depend upon both the total amount of the dose given, as well as the frequency with which it is administered. The objective of the study then becomes to find an acceptable combination of both dose and schedule. Past literature on designing these trials has entailed the assumption that toxicity increases monotonically with both dose and schedule. In this article, we relax this assumption for schedules and present a dose-schedule finding design that can be generalized to situations in which we know the ordering between all schedules and those in which we do not. We present simulation results that compare our method to other suggested dose-schedule finding methodology. PMID:24114957

  17. Treatment for Acquired Apraxia of Speech: Examination of Treatment Intensity and Practice Schedule

    ERIC Educational Resources Information Center

    Wambaugh, Julie L.; Nessler, Christina; Cameron, Rosalea; Mauszycki, Shannon C.

    2013-01-01

    Purpose: The authors designed this investigation to extend the development of a treatment for acquired apraxia of speech (AOS)--sound production treatment (SPT)--by examining the effects of 2 treatment intensities and 2 schedules of practice. Method: The authors used a multiple baseline design across participants and behaviors with 4 speakers with…

  18. 7 CFR 305.9 - Aerosol spray for aircraft treatment schedule.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 5 2010-01-01 2010-01-01 false Aerosol spray for aircraft treatment schedule. 305.9 Section 305.9 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE PHYTOSANITARY TREATMENTS Chemical Treatments § 305.9 Aerosol...

  19. Chemotherapy and treatment scheduling: the Johns Hopkins Oncology Center Outpatient Department.

    PubMed Central

    Majidi, F.; Enterline, J. P.; Ashley, B.; Fowler, M. E.; Ogorzalek, L. L.; Gaudette, R.; Stuart, G. J.; Fulton, M.; Ettinger, D. S.

    1993-01-01

    The Chemotherapy and Treatment Scheduling System provides integrated appointment and facility scheduling for very complex procedures. It is fully integrated with other scheduling systems at The Johns Hopkins Oncology Center and is supported by the Oncology Clinical Information System (OCIS). It provides a combined visual and textual environment for the scheduling of events that have multiple dimensions and dependencies on other scheduled events. It is also fully integrated with other clinical decision support and ancillary systems within OCIS. The system has resulted in better patient flow through the ambulatory care areas of the Center. Implementing the system required changes in behavior among physicians, staff, and patients. This system provides a working example of building a sophisticated rule-based scheduling system using a relatively simple paradigm. It also is an example of what can be achieved when there is total integration between the operational and clinical components of patient care automation. PMID:8130453

  20. Using Multiple Schedules During Functional Communication Training to Promote Rapid Transfer of Treatment Effects

    PubMed Central

    Fisher, Wayne W.; Greer, Brian D.; Fuhrman, Ashley M.; Querim, Angie C.

    2016-01-01

    Multiple schedules with signaled periods of reinforcement and extinction have been used to thin reinforcement schedules during functional communication training (FCT) to make the intervention more practical for parents and teachers. We evaluated whether these signals would also facilitate rapid transfer of treatment effects from one setting to the next and from one therapist to the next. With two children, we conducted FCT in the context of mixed (baseline) and multiple (treatment) schedules introduced across settings or therapists using a multiple baseline design. Results indicated that when the multiple schedules were introduced, the functional communication response came under rapid discriminative control, and problem behavior remained at near-zero rates. We extended these findings with another individual by using a more traditional baseline in which problem behavior produced reinforcement. Results replicated those of the previous participants and showed rapid reductions in problem behavior when multiple schedules were implemented across settings. PMID:26384141

  1. Using multiple schedules during functional communication training to promote rapid transfer of treatment effects.

    PubMed

    Fisher, Wayne W; Greer, Brian D; Fuhrman, Ashley M; Querim, Angie C

    2015-12-01

    Multiple schedules with signaled periods of reinforcement and extinction have been used to thin reinforcement schedules during functional communication training (FCT) to make the intervention more practical for parents and teachers. We evaluated whether these signals would also facilitate rapid transfer of treatment effects across settings and therapists. With 2 children, we conducted FCT in the context of mixed (baseline) and multiple (treatment) schedules introduced across settings or therapists using a multiple baseline design. Results indicated that when the multiple schedules were introduced, the functional communication response came under rapid discriminative control, and problem behavior remained at near-zero rates. We extended these findings with another individual by using a more traditional baseline in which problem behavior produced reinforcement. Results replicated those of the previous participants and showed rapid reductions in problem behavior when multiple schedules were implemented across settings. © Society for the Experimental Analysis of Behavior.

  2. Using Multiple Schedules during Functional Communication Training to Promote Rapid Transfer of Treatment Effects

    ERIC Educational Resources Information Center

    Fisher, Wayne W.; Greer, Brian D.; Fuhrman, Ashley M.; Querim, Angie C.

    2015-01-01

    Multiple schedules with signaled periods of reinforcement and extinction have been used to thin reinforcement schedules during functional communication training (FCT) to make the intervention more practical for parents and teachers. We evaluated whether these signals would also facilitate rapid transfer of treatment effects across settings and…

  3. 7 CFR 305.26 - Khapra beetle treatment schedule for feeds and milled products.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE PHYTOSANITARY TREATMENTS Heat... requirements. This treatment must be specifically authorized in each case by the Director of Plant Health... 7 Agriculture 5 2010-01-01 2010-01-01 false Khapra beetle treatment schedule for feeds and milled...

  4. 7 CFR 305.3 - Processes for adding, revising, or removing treatment schedules in the PPQ Treatment Manual.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 5 2012-01-01 2012-01-01 false Processes for adding, revising, or removing treatment schedules in the PPQ Treatment Manual. 305.3 Section 305.3 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE PHYTOSANITARY...

  5. Design of Chronomodulated Drug Delivery System of Valsartan: In Vitro Characterization.

    PubMed

    Sokar, M; Hanafy, A; Elkamel, A; El-Gamal, S

    2015-01-01

    The aim of the present study was to design and evaluate a chronomodulated time-clock pulsatile tablets of valsartan to release it after a certain lag time, independent of the gastrointestinal pH, in its absorption window to cope with the circadian rhythm of human body for blood pressure elevation. Core tablets were prepared by direct compression of a homogenous mixture of valsartan, Avicel PH101, croscarmellose sodium, magnesium stearate and Aerosil. The core tablets were then sprayed coated with a sealing layer formed of ethyl cellulose that was subsequently coated with a release-controlling layer. Three different aqueous dispersions namely; carnauba wax or beeswax or a mixture in a ratio of 2.5:1, respectively, were used to form five time-clock tablet formulations having the release controlling layer with different thickness {B5, B10, B20, BW5 and CW5}. Quality control testing were carried out to the core tablets. Differential scanning calorimetry was also performed to detect the possible drug excipient interaction in the core tablet formulation. The release was carried out, for the prepared time-clock tablet formulations, in 0.1 N hydrochloric acid for the first 2 h, followed by phosphate buffer (pH 6.8) for 4.5 h. The effect of pH on valsartan release was studied through a release study in 0.1 N hydrochloric acid for 6.5 h. Two phase dissolution study was performed to the selected time-clock tablet formulation to predict the drug permeation through the gastrointestinal tract. Stability study of the selected formula was performed at 25°/60% RH and at 40°/75% RH for 3 months. Results showed that a release-controlling layer composed of a mixture of carnauba wax and beeswax in a ratio of 2.5:1 showed a reasonable release lag time. The release lag time of the tablets increased with the increase of the coat thickness, thus B20>B10>B5 with corresponding lag time values of 4.5, 3 and 2.5 h, respectively. Selected B5 tablet formula exhibited a reasonable lag time

  6. Dose Schedule and Enhanced Conversational Recast Treatment for Children with Specific Language Impairment

    ERIC Educational Resources Information Center

    Meyers-Denman, Christina N.; Plante, Elena

    2016-01-01

    Purpose: Dosage has been identified as an important element of treatment that may affect treatment efficacy. The purpose of this study was to examine the role of dose schedule for treatment of grammatical morphology deficits in children with specific language impairment (SLI). Method: Sixteen 4-to-5-year-old children with SLI participated in a…

  7. 29 CFR 825.203 - Scheduling of intermittent or reduced schedule leave.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... OF LABOR OTHER LAWS THE FAMILY AND MEDICAL LEAVE ACT OF 1993 Employee Leave Entitlements Under the Family and Medical Leave Act § 825.203 Scheduling of intermittent or reduced schedule leave. Eligible... leave intermittently or on a reduced leave schedule for planned medical treatment, then the employee...

  8. 29 CFR 825.203 - Scheduling of intermittent or reduced schedule leave.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... OF LABOR OTHER LAWS THE FAMILY AND MEDICAL LEAVE ACT OF 1993 Employee Leave Entitlements Under the Family and Medical Leave Act § 825.203 Scheduling of intermittent or reduced schedule leave. Eligible... leave intermittently or on a reduced leave schedule for planned medical treatment, then the employee...

  9. 29 CFR 825.203 - Scheduling of intermittent or reduced schedule leave.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... OF LABOR OTHER LAWS THE FAMILY AND MEDICAL LEAVE ACT OF 1993 Employee Leave Entitlements Under the Family and Medical Leave Act § 825.203 Scheduling of intermittent or reduced schedule leave. Eligible... leave intermittently or on a reduced leave schedule for planned medical treatment, then the employee...

  10. 29 CFR 825.203 - Scheduling of intermittent or reduced schedule leave.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... OF LABOR OTHER LAWS THE FAMILY AND MEDICAL LEAVE ACT OF 1993 Employee Leave Entitlements Under the Family and Medical Leave Act § 825.203 Scheduling of intermittent or reduced schedule leave. Eligible... leave intermittently or on a reduced leave schedule for planned medical treatment, then the employee...

  11. A treatment schedule of conventional physical therapy provided to enhance upper limb sensorimotor recovery after stroke: expert criterion validity and intra-rater reliability.

    PubMed

    Donaldson, Catherine; Tallis, Raymond C; Pomeroy, Valerie M

    2009-06-01

    Inadequate description of treatment hampers progress in stroke rehabilitation. To develop a valid, reliable, standardised treatment schedule of conventional physical therapy provided for the paretic upper limb after stroke. Eleven neurophysiotherapists participated in the established methodology: semi-structured interviews, focus groups and piloting a draft treatment schedule in clinical practice. Different physiotherapists (n=13) used the treatment schedule to record treatment given to stroke patients with mild, moderate and severe upper limb paresis. Rating of adequacy of the treatment schedule was made using a visual analogue scale (0 to 100mm). Mean (95% confidence interval) visual analogue scores were calculated (expert criterion validity). For intra-rater reliability, each physiotherapist observed a video tape of their treatment and immediately completed a treatment schedule recording form on two separate occasions, 4 to 6 weeks apart. The Kappa statistic was calculated for intra-rater reliability. The treatment schedule consists of a one-page A4 recording form and a user booklet, detailing 50 treatment activities. Expert criterion validity was 79 (95% confidence interval 74 to 84). Intra-rater Kappa was 0.81 (P<0.001). This treatment schedule can be used to document conventional physical therapy in subsequent clinical trials in the geographical area of its development. Further work is needed to investigate generalisability beyond this geographical area.

  12. Design of Chronomodulated Drug Delivery System of Valsartan: In Vitro Characterization

    PubMed Central

    Sokar, M.; Hanafy, A.; Elkamel, A.; El-Gamal, S.

    2015-01-01

    The aim of the present study was to design and evaluate a chronomodulated time-clock pulsatile tablets of valsartan to release it after a certain lag time, independent of the gastrointestinal pH, in its absorption window to cope with the circadian rhythm of human body for blood pressure elevation. Core tablets were prepared by direct compression of a homogenous mixture of valsartan, Avicel PH101, croscarmellose sodium, magnesium stearate and Aerosil. The core tablets were then sprayed coated with a sealing layer formed of ethyl cellulose that was subsequently coated with a release-controlling layer. Three different aqueous dispersions namely; carnauba wax or beeswax or a mixture in a ratio of 2.5:1, respectively, were used to form five time-clock tablet formulations having the release controlling layer with different thickness {B5, B10, B20, BW5 and CW5}. Quality control testing were carried out to the core tablets. Differential scanning calorimetry was also performed to detect the possible drug excipient interaction in the core tablet formulation. The release was carried out, for the prepared time-clock tablet formulations, in 0.1 N hydrochloric acid for the first 2 h, followed by phosphate buffer (pH 6.8) for 4.5 h. The effect of pH on valsartan release was studied through a release study in 0.1 N hydrochloric acid for 6.5 h. Two phase dissolution study was performed to the selected time-clock tablet formulation to predict the drug permeation through the gastrointestinal tract. Stability study of the selected formula was performed at 25°/60% RH and at 40°/75% RH for 3 months. Results showed that a release-controlling layer composed of a mixture of carnauba wax and beeswax in a ratio of 2.5:1 showed a reasonable release lag time. The release lag time of the tablets increased with the increase of the coat thickness, thus B20>B10>B5 with corresponding lag time values of 4.5, 3 and 2.5 h, respectively. Selected B5 tablet formula exhibited a reasonable lag time

  13. Alcohol withdrawal syndrome: symptom-triggered versus fixed-schedule treatment in an outpatient setting.

    PubMed

    Elholm, Bjarne; Larsen, Klaus; Hornnes, Nete; Zierau, Finn; Becker, Ulrik

    2011-01-01

    To investigate whether, in the treatment with chlordiazepoxide for outpatient alcohol withdrawal, there are advantages of symptom-triggered self-medication over a fixed-schedule regimen. A randomized controlled trial in outpatient clinics for people suffering from alcohol dependence (AD) and alcohol-related problems; 165 adult patients in an outpatient setting in a specialized alcohol treatment unit were randomized 1:1 to either a symptom-triggered self-medication or tapered dose, using chlordiazepoxide. Alcohol withdrawal symptoms, amount of medication, duration of symptoms, time to relapse and patient satisfaction were measured. Patients assessed their symptoms using the Short Alcohol Withdrawal Scale (SAWS). Patient satisfaction was monitored by the Diabetes Treatment Satisfaction Questionnaire. We used the Well-Being Index and the European addiction severity index for the 1-year follow-up. We found no differences in the quantity of medication consumed, time to relapse, well being or treatment satisfaction. Symptom-triggered self-medication was as safe as fixed-schedule medication in treating outpatients with AD and mild to moderate symptoms of AWS. The SAWS is a powerful monitoring tool, because it is brief and permits the subject to log the withdrawal symptoms.

  14. A WHO study of treatment schedules for early syphilis in use throughout the world

    PubMed Central

    Willcox, R. R.

    1954-01-01

    Ten years have elapsed since penicillin was introduced in the treatment of syphilis. In order to appraise recent trends in syphilotherapy in the world, WHO carried out a detailed study of treatment practices in early syphilis. A questionnaire was circulated to leading venereologists and clinics in the world, and 277 replies were received from 55 countries giving particulars of 294 schedules. A total of 65.3% of the participants used penicillin alone and 28.9% used it in combination with other drugs. In North America all clinics relied solely on penicillin as against 52.2% in Europe; and procaine penicillin G in oil with aluminium monostearate (PAM) was used in 91% of clinics in the Americas and Asia and in 60.6% of European clinics. The most common dosage of penicillin in all stages of early syphilis was 4.8-6.0 million units; but appreciably larger doses were used in Europe than elsewhere, some 39.4% of schedules using 10.8 million units or more. There were single instances of 36 million units being given. Consolidation treatment was given in none of the North American clinics; seldom in Asia; by about one-third of the participants in Central and South America; and, for secondary syphilis, in 59% of European schedules. This study shows that with intensive treatment with PAM the saving in drug cost to clinics over the classical courses of arsenic and bismuth may be as much as £4 per case, but the overhead expenses are, of course, not reduced. PMID:13182588

  15. Developing an efficient scheduling template of a chemotherapy treatment unit: A case study.

    PubMed

    Ahmed, Z; Elmekkawy, Ty; Bates, S

    2011-01-01

    This study was undertaken to improve the performance of a Chemotherapy Treatment Unit by increasing the throughput and reducing the average patient's waiting time. In order to achieve this objective, a scheduling template has been built. The scheduling template is a simple tool that can be used to schedule patients' arrival to the clinic. A simulation model of this system was built and several scenarios, that target match the arrival pattern of the patients and resources availability, were designed and evaluated. After performing detailed analysis, one scenario provide the best system's performance. A scheduling template has been developed based on this scenario. After implementing the new scheduling template, 22.5% more patients can be served. 1. CancerCare Manitoba is a provincially mandated cancer care agency. It is dedicated to provide quality care to those who have been diagnosed and are living with cancer. MacCharles Chemotherapy unit is specially built to provide chemotherapy treatment to the cancer patients of Winnipeg. In order to maintain an excellent service, it tries to ensure that patients get their treatment in a timely manner. It is challenging to maintain that goal because of the lack of a proper roster, the workload distribution and inefficient resource allotment. In order to maintain the satisfaction of the patients and the healthcare providers, by serving the maximum number of patients in a timely manner, it is necessary to develop an efficient scheduling template that matches the required demand with the availability of resources. This goal can be reached using simulation modelling. Simulation has proven to be an excellent modelling tool. It can be defined as building computer models that represent real world or hypothetical systems, and hence experimenting with these models to study system behaviour under different scenarios.1, 2 A study was undertaken at the Children's Hospital of Eastern Ontario to identify the issues behind the long waiting

  16. Infusional 5-FU for advanced colorectal cancer.

    PubMed

    Lokich, J

    1995-01-01

    5-Fluorouracil (5-FU) has been studied over the past two decades in five prospective randomized trials comparing bolus with infusional schedules. Response rates and time to progression are improved with infusional schedules and survival as determined by the proportion of patients alive at 2 years is also superior for infusional administration. Biochemical modulation of infusional 5-FU by leucovorin or interferon does not increase the therapeutic effect (in contrast to the modulation of bolus delivery) but does effect the toxicity profile adversely. Time modulation of infusional 5-FU has been reported to improve response rates, and survival over constant or flat infusion and additional studies are ongoing. A proposed experimental design for a comparative trial in advanced colon cancer is presented to address the questions of the optimal infusion duration; the role of dose intensity; and the role of chronomodulation. The application of infusional 5-FU into the adjuvant setting seems to be a reasonable step, and such trials have been initiated in both the United States and the United Kingdom. Bolus single agent 5-FU should be abandoned as a treatment option for colon cancer.

  17. Methods to model and predict the ViewRay treatment deliveries to aid patient scheduling and treatment planning

    PubMed Central

    Liu, Shi; Wu, Yu; Wooten, H. Omar; Green, Olga; Archer, Brent; Li, Harold

    2016-01-01

    A software tool is developed, given a new treatment plan, to predict treatment delivery time for radiation therapy (RT) treatments of patients on ViewRay magnetic resonance image‐guided radiation therapy (MR‐IGRT) delivery system. This tool is necessary for managing patient treatment scheduling in our clinic. The predicted treatment delivery time and the assessment of plan complexities could also be useful to aid treatment planning. A patient's total treatment delivery time, not including time required for localization, is modeled as the sum of four components: 1) the treatment initialization time; 2) the total beam‐on time; 3) the gantry rotation time; and 4) the multileaf collimator (MLC) motion time. Each of the four components is predicted separately. The total beam‐on time can be calculated using both the planned beam‐on time and the decay‐corrected dose rate. To predict the remain‐ing components, we retrospectively analyzed the patient treatment delivery record files. The initialization time is demonstrated to be random since it depends on the final gantry angle of the previous treatment. Based on modeling the relationships between the gantry rotation angles and the corresponding rotation time, linear regression is applied to predict the gantry rotation time. The MLC motion time is calculated using the leaves delay modeling method and the leaf motion speed. A quantitative analysis was performed to understand the correlation between the total treatment time and the plan complexity. The proposed algorithm is able to predict the ViewRay treatment delivery time with the average prediction error 0.22 min or 1.82%, and the maximal prediction error 0.89 min or 7.88%. The analysis has shown the correlation between the plan modulation (PM) factor and the total treatment delivery time, as well as the treatment delivery duty cycle. A possibility has been identified to significantly reduce MLC motion time by optimizing the positions of closed MLC pairs. The

  18. Methods to model and predict the ViewRay treatment deliveries to aid patient scheduling and treatment planning.

    PubMed

    Liu, Shi; Wu, Yu; Wooten, H Omar; Green, Olga; Archer, Brent; Li, Harold; Yang, Deshan

    2016-03-08

    A software tool is developed, given a new treatment plan, to predict treatment delivery time for radiation therapy (RT) treatments of patients on ViewRay magnetic resonance image-guided radiation therapy (MR-IGRT) delivery system. This tool is necessary for managing patient treatment scheduling in our clinic. The predicted treatment delivery time and the assessment of plan complexities could also be useful to aid treatment planning. A patient's total treatment delivery time, not including time required for localization, is modeled as the sum of four components: 1) the treatment initialization time; 2) the total beam-on time; 3) the gantry rotation time; and 4) the multileaf collimator (MLC) motion time. Each of the four components is predicted separately. The total beam-on time can be calculated using both the planned beam-on time and the decay-corrected dose rate. To predict the remain-ing components, we retrospectively analyzed the patient treatment delivery record files. The initialization time is demonstrated to be random since it depends on the final gantry angle of the previous treatment. Based on modeling the relationships between the gantry rotation angles and the corresponding rotation time, linear regression is applied to predict the gantry rotation time. The MLC motion time is calculated using the leaves delay modeling method and the leaf motion speed. A quantitative analysis was performed to understand the correlation between the total treatment time and the plan complexity. The proposed algorithm is able to predict the ViewRay treatment delivery time with the average prediction error 0.22min or 1.82%, and the maximal prediction error 0.89 min or 7.88%. The analysis has shown the correlation between the plan modulation (PM) factor and the total treatment delivery time, as well as the treatment delivery duty cycle. A possibility has been identified to significantly reduce MLC motion time by optimizing the positions of closed MLC pairs. The accuracy of

  19. Treatment of Escape-Maintained Challenging Behavior Using Chained Schedules: An Evaluation of the Effects of Thinning Positive plus Negative Reinforcement During Functional Communication Training.

    PubMed

    Zangrillo, Amanda N; Fisher, Wayne W; Greer, Brian D; Owen, Todd M; DeSouza, Andresa A

    2016-01-01

    Previous research has supported functional communication training (FCT) as an effective intervention for reducing challenging behavior. Clinicians often program schedule-thinning procedures to increase the portability of the treatment (i.e., reinforcement is provided less frequently). For individuals with escape-maintained problem behavior, chained schedules have proven effective in increasing task completion and supplemental procedures may ameliorate reemergence of challenging behavior as access to reinforcement is decreased. The present study compared the use of a chained schedule-thinning procedure with and without alternative reinforcement (e.g., toys and activities) embedded in an intervention in which escape from the task is provided contingent on a request for a break. Two individuals with escape-maintained challenging behavior participated. We compared two treatment conditions, escape-only and escape-to-tangibles, using a single-subject, alternating treatments design with each treatment implemented in a distinct academic context. With the escape-to-tangibles treatment, we reached the final schedule in both contexts with both participants (4 successes out of 4 applications). We did not reach the final schedule with either participant with the escape-only intervention (0 successes out of 2 applications). The current results provided preliminary confirmation that providing positive plus negative reinforcement would decrease destructive behavior, increase compliance, and facilitate reinforcer-schedule thinning.

  20. Treatment of Escape-Maintained Challenging Behavior Using Chained Schedules: An Evaluation of the Effects of Thinning Positive plus Negative Reinforcement During Functional Communication Training

    PubMed Central

    Zangrillo, Amanda N.; Fisher, Wayne W.; Greer, Brian D.; Owen, Todd M.; DeSouza, Andresa A.

    2016-01-01

    Objective Previous research has supported functional communication training (FCT) as an effective intervention for reducing challenging behavior. Clinicians often program schedule-thinning procedures to increase the portability of the treatment (i.e., reinforcement is provided less frequently). For individuals with escape-maintained problem behavior, chained schedules have proven effective in increasing task completion and supplemental procedures may ameliorate reemergence of challenging behavior as access to reinforcement is decreased. The present study compared the use of a chained schedule-thinning procedure with and without alternative reinforcement (e.g., toys and activities) embedded in an intervention in which escape from the task is provided contingent on a request for a break. Method Two individuals with escape-maintained challenging behavior participated. We compared two treatment conditions, escape-only and escape-to-tangibles, using a single-subject, alternating treatments design with each treatment implemented in a distinct academic context. Results With the escape-to-tangibles treatment, we reached the final schedule in both contexts with both participants (4 successes out of 4 applications). We did not reach the final schedule with either participant with the escape-only intervention (0 successes out of 2 applications). Conclusion The current results provided preliminary confirmation that providing positive plus negative reinforcement would decrease destructive behavior, increase compliance, and facilitate reinforcer-schedule thinning. PMID:28626579

  1. Effects of 14-day treatment with the schedule III anorectic phendimetrazine on choice between cocaine and food in rhesus monkeys.

    PubMed

    Banks, Matthew L; Blough, Bruce E; Negus, S Stevens

    2013-08-01

    The clinical utility of monoamine releasers such as phenmetrazine or d-amphetamine as candidate agonist medications for cocaine dependence is hindered by their high abuse liability. Phendimetrazine is a clinically available schedule III anorectic that functions as a prodrug for phenmetrazine and thus may have lower abuse liability. This study determined the effects of continuous 14-day treatment with phendimetrazine on cocaine vs. food choice in rhesus monkeys (N=4). Responding was maintained under a concurrent schedule of food delivery (1-g pellets, fixed-ratio 100 schedule) and cocaine injections (0-0.1mg/kg/injection, fixed-ratio 10 schedule). Cocaine choice dose-effect curves were determined daily before and during 14-day periods of continuous intravenous treatment with saline or (+)-phendimetrazine (0.32-1.0mg/kg/h). Effects of 14-day treatment with (+)-phenmetrazine (0.1-0.32 mg/kg/h; N=5) and d-amphetamine (0.032-0.1mg/kg/h; N=6) were also examined for comparison. During saline treatment, food was primarily chosen during availability of low cocaine doses (0, 0.0032, and 0.01 mg/kg/injection), and cocaine was primarily chosen during availability of higher cocaine doses (0.032 and 0.1mg/kg/injection). Phendimetrazine initially decreased overall responding without significantly altering cocaine choice. Over the course of 14 days, tolerance developed to rate decreasing effects, and phendimetrazine dose-dependently decreased cocaine choice (significant at 0.032 mg/kg/injection cocaine). Phenmetrazine and d-amphetamine produced qualitatively similar effects. These results demonstrate that phendimetrazine can produce significant, though modest, reductions in cocaine choice in rhesus monkeys. Phendimetrazine may be especially suitable as a candidate medication for human studies because of its schedule III clinical availability. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

  2. An Investigation of Treatment Scheduling for Phonemic Awareness with Kindergartners Who Are at Risk for Reading Difficulties

    ERIC Educational Resources Information Center

    Ukrainetz, Teresa A.; Ross, Catherine L.; Harm, Heide M.

    2009-01-01

    Purpose: This study examined 2 schedules of treatment for phonemic awareness. Method: Forty-one 5- to 6-year-old kindergartners, including 22 English learners, with low letter-name and first-sound knowledge received 11 hr of phonemic awareness treatment: concentrated (CP, 3x/wk to December), dispersed (DP, 1x/wk to March), and dispersed vocabulary…

  3. Integrated resource scheduling in a distributed scheduling environment

    NASA Technical Reports Server (NTRS)

    Zoch, David; Hall, Gardiner

    1988-01-01

    The Space Station era presents a highly-complex multi-mission planning and scheduling environment exercised over a highly distributed system. In order to automate the scheduling process, customers require a mechanism for communicating their scheduling requirements to NASA. A request language that a remotely-located customer can use to specify his scheduling requirements to a NASA scheduler, thus automating the customer-scheduler interface, is described. This notation, Flexible Envelope-Request Notation (FERN), allows the user to completely specify his scheduling requirements such as resource usage, temporal constraints, and scheduling preferences and options. The FERN also contains mechanisms for representing schedule and resource availability information, which are used in the inter-scheduler inconsistency resolution process. Additionally, a scheduler is described that can accept these requests, process them, generate schedules, and return schedule and resource availability information to the requester. The Request-Oriented Scheduling Engine (ROSE) was designed to function either as an independent scheduler or as a scheduling element in a network of schedulers. When used in a network of schedulers, each ROSE communicates schedule and resource usage information to other schedulers via the FERN notation, enabling inconsistencies to be resolved between schedulers. Individual ROSE schedules are created by viewing the problem as a constraint satisfaction problem with a heuristically guided search strategy.

  4. 45 CFR 96.137 - Payment schedule.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 1 2014-10-01 2014-10-01 false Payment schedule. 96.137 Section 96.137 Public Welfare Department of Health and Human Services GENERAL ADMINISTRATION BLOCK GRANTS Substance Abuse Prevention and Treatment Block Grant § 96.137 Payment schedule. (a) The Block Grant money that may be spent...

  5. 45 CFR 96.137 - Payment schedule.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 1 2012-10-01 2012-10-01 false Payment schedule. 96.137 Section 96.137 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION BLOCK GRANTS Substance Abuse Prevention and Treatment Block Grant § 96.137 Payment schedule. (a) The Block Grant money that may be spent...

  6. 45 CFR 96.137 - Payment schedule.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 1 2011-10-01 2011-10-01 false Payment schedule. 96.137 Section 96.137 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION BLOCK GRANTS Substance Abuse Prevention and Treatment Block Grant § 96.137 Payment schedule. (a) The Block Grant money that may be spent...

  7. 45 CFR 96.137 - Payment schedule.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 1 2013-10-01 2013-10-01 false Payment schedule. 96.137 Section 96.137 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION BLOCK GRANTS Substance Abuse Prevention and Treatment Block Grant § 96.137 Payment schedule. (a) The Block Grant money that may be spent...

  8. 45 CFR 96.137 - Payment schedule.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Payment schedule. 96.137 Section 96.137 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION BLOCK GRANTS Substance Abuse Prevention and Treatment Block Grant § 96.137 Payment schedule. (a) The Block Grant money that may be spent...

  9. Transit scheduling: Basic and advanced manuals. Final report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Pine, R.; Niemeyer, J.; Chisholm, R.

    1998-12-01

    This manual will be of interest to new transit schedulers, experienced schedulers, transit planners, operating staff, and others who need to be conversant with the scheduling process. The materials clearly describe all steps in the bus and light rail scheduling process, under TCRP Project A-11, Transit Scheduling: A Manual with Materials, research was undertaken by Transportation Management and Design of Solana Beach, California, to prepare a transit scheduling manual that incorporates modern training techniques for bus and light rail transit scheduling. The manual consists of two sections: a basic treatment and an advanced section. The basic-level section is in anmore » instructional format designed primarily for novice schedulers and other transit staff. The advance section covers more complex scheduling requirements. Each section may be used sequentially or independently and is designed to integrate with agency apprenticeship and on-the-job training.« less

  10. Wave scheduling - Decentralized scheduling of task forces in multicomputers

    NASA Technical Reports Server (NTRS)

    Van Tilborg, A. M.; Wittie, L. D.

    1984-01-01

    Decentralized operating systems that control large multicomputers need techniques to schedule competing parallel programs called task forces. Wave scheduling is a probabilistic technique that uses a hierarchical distributed virtual machine to schedule task forces by recursively subdividing and issuing wavefront-like commands to processing elements capable of executing individual tasks. Wave scheduling is highly resistant to processing element failures because it uses many distributed schedulers that dynamically assign scheduling responsibilities among themselves. The scheduling technique is trivially extensible as more processing elements join the host multicomputer. A simple model of scheduling cost is used by every scheduler node to distribute scheduling activity and minimize wasted processing capacity by using perceived workload to vary decentralized scheduling rules. At low to moderate levels of network activity, wave scheduling is only slightly less efficient than a central scheduler in its ability to direct processing elements to accomplish useful work.

  11. Online stochastic optimization of radiotherapy patient scheduling.

    PubMed

    Legrain, Antoine; Fortin, Marie-Andrée; Lahrichi, Nadia; Rousseau, Louis-Martin

    2015-06-01

    The effective management of a cancer treatment facility for radiation therapy depends mainly on optimizing the use of the linear accelerators. In this project, we schedule patients on these machines taking into account their priority for treatment, the maximum waiting time before the first treatment, and the treatment duration. We collaborate with the Centre Intégré de Cancérologie de Laval to determine the best scheduling policy. Furthermore, we integrate the uncertainty related to the arrival of patients at the center. We develop a hybrid method combining stochastic optimization and online optimization to better meet the needs of central planning. We use information on the future arrivals of patients to provide an accurate picture of the expected utilization of resources. Results based on real data show that our method outperforms the policies typically used in treatment centers.

  12. Completable scheduling: An integrated approach to planning and scheduling

    NASA Technical Reports Server (NTRS)

    Gervasio, Melinda T.; Dejong, Gerald F.

    1992-01-01

    The planning problem has traditionally been treated separately from the scheduling problem. However, as more realistic domains are tackled, it becomes evident that the problem of deciding on an ordered set of tasks to achieve a set of goals cannot be treated independently of the problem of actually allocating resources to the tasks. Doing so would result in losing the robustness and flexibility needed to deal with imperfectly modeled domains. Completable scheduling is an approach which integrates the two problems by allowing an a priori planning module to defer particular planning decisions, and consequently the associated scheduling decisions, until execution time. This allows a completable scheduling system to maximize plan flexibility by allowing runtime information to be taken into consideration when making planning and scheduling decision. Furthermore, through the criteria of achievability placed on deferred decision, a completable scheduling system is able to retain much of the goal-directedness and guarantees of achievement afforded by a priori planning. The completable scheduling approach is further enhanced by the use of contingent explanation-based learning, which enables a completable scheduling system to learn general completable plans from example and improve its performance through experience. Initial experimental results show that completable scheduling outperforms classical scheduling as well as pure reactive scheduling in a simple scheduling domain.

  13. Simultaneously optimizing dose and schedule of a new cytotoxic agent.

    PubMed

    Braun, Thomas M; Thall, Peter F; Nguyen, Hoang; de Lima, Marcos

    2007-01-01

    Traditionally, phase I clinical trial designs are based upon one predefined course of treatment while varying among patients the dose given at each administration. In actual medical practice, patients receive a schedule comprised of several courses of treatment, and some patients may receive one or more dose reductions or delays during treatment. Consequently, the overall risk of toxicity for each patient is a function of both actual schedule of treatment and the differing doses used at each adminstration. Our goal is to provide a practical phase I clinical trial design that more accurately reflects actual medical practice by accounting for both dose per administration and schedule. We propose an outcome-adaptive Bayesian design that simultaneously optimizes both dose and schedule in terms of the overall risk of toxicity, based on time-to-toxicity outcomes. We use computer simulation as a tool to calibrate design parameters. We describe a phase I trial in allogeneic bone marrow transplantation that was designed and is currently being conducted using our new method. Our computer simulations demonstrate that our method outperforms any method that searches for an optimal dose but does not allow schedule to vary, both in terms of the probability of identifying optimal (dose, schedule) combinations, and the numbers of patients assigned to those combinations in the trial. Our design requires greater sample sizes than those seen in traditional phase I studies due to the larger number of treatment combinations examined. Our design also assumes that the effects of multiple administrations are independent of each other and that the hazard of toxicity is the same for all administrations. Our design is the first for phase I clinical trials that is sufficiently flexible and practical to truly reflect clinical practice by varying both dose and the timing and number of administrations given to each patient.

  14. Metronomic cyclophosphamide schedule-dependence of innate immune cell recruitment and tumor regression in an implanted glioma model

    PubMed Central

    Wu, Junjie; Waxman, David J.

    2014-01-01

    Metronomic cyclophosphamide (CPA) treatment activates robust innate anti-tumor immunity and induces major regression of large, implanted brain tumor xenografts when administered on an intermittent, every 6-day schedule, but not on a daily low-dose or a maximum-tolerated dose CPA schedule. Here, we used an implanted GL261 glioma model to compare five intermittent metronomic CPA schedules to elucidate the kinetics and schedule dependence of innate immune cell recruitment and tumor regression. Tumor-recruited natural killer cells induced by two every 6-day treatment cycles were significantly ablated one day after a third CPA treatment, but largely recovered several days later. Natural killer and other tumor-infiltrating innate immune cells peaked 12 days after the last CPA treatment on the every 6-day schedule, suggesting that drug-free intervals longer than 6 days may show increased efficacy. Metronomic CPA treatments spaced 9 or 12 days apart, or on an alternating 6 and 9 day schedule, induced extensive tumor regression, similar to the 6-day schedule, however, the tumor-infiltrating natural killer cell responses were not sustained, leading to rapid resumption of tumor regrowth after day 24, despite ongoing metronomic CPA treatment. Increasing the CPA dose prolonged the period of tumor regression on the every 9-day schedule, but natural killer cell activation was markedly decreased. Thus, while several intermittent metronomic CPA treatment schedules can activate innate immune cell recruitment leading to major tumor regression, sustained immune and anti-tumor responses are only achieved on the 6-day schedule. However, even with this schedule, some tumors eventually relapse, indicating a need for further improvements in immunogenic metronomic therapies. PMID:25069038

  15. Alternative Work Schedules Increase Employee Satisfaction.

    ERIC Educational Resources Information Center

    Turney, John R.; Cohen, Stanley L.

    1983-01-01

    Facets of alternative work schedules (AWS) are discussed: importance of employee control, possible negative consequences, AWS handbook, time monitoring systems, and treatment of exceptions. AWS' effect on productivity and motivation is examined. (SK)

  16. Affirmative Action: The Scheduled Castes and the Scheduled Tribes.

    ERIC Educational Resources Information Center

    Sivaramayya, B.

    This paper considers Indian affirmative action policies that provide reservations (quotas) in favor of two disadvantaged groups, the scheduled castes and the scheduled tribes. First, definitions and background are presented. The scheduled castes ("untouchables") are said to suffer from social segregation, and the scheduled tribes from…

  17. Treatment of Gonorrhea with Spectinomycin Hydrochloride: Comparison with Standard Penicillin Schedules

    PubMed Central

    Duncan, W. Christopher; Holder, William R.; Roberts, David P.; Knox, John M.

    1972-01-01

    Spectinomycin hydrochloride, a new parenteral antibiotic prepared from Streptomyces spectabilis, was compared with standard U.S. Public Health Service-recommended dosages of aqueous procaine penicillin G in the treatment of uncomplicated gonorrhea in 353 men and 314 women. Of the 314 women, 130 had a pretreatment positive rectal culture. All diagnoses were proven by culture on Thayer-Martin selective medium. Minimal inhibitory concentrations of both drugs were determined. Single doses of 2 and 4 g of spectinomycin were compared with 2.4 million units of procaine penicillin in males and with both 2.4 and 4.8 million units of procaine penicillin in females. Both spectinomycin schedules, 2.4 million units of penicillin in males and 4.8 million units of penicillin in females, resulted in cure rates in excess of 90%. There were no failures at the rectal site only in those women with positive rectal cultures. There was no advantage to using the larger amount of spectinomycin in either sex. PMID:4261553

  18. 75 FR 42831 - Proposed Collection; Comment Request for Form 1065, Schedule C, Schedule D, Schedule K-1...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-22

    ... Income, Credits, Deductions and Other Items), Schedule L (Balance Sheets per Books), Schedule M-1..., Deductions, etc. (Schedule K-1), Balance Sheets per Books (Schedule L), Reconciliation of Income (Loss) per...

  19. Automation Improves Schedule Quality and Increases Scheduling Efficiency for Residents.

    PubMed

    Perelstein, Elizabeth; Rose, Ariella; Hong, Young-Chae; Cohn, Amy; Long, Micah T

    2016-02-01

    Medical resident scheduling is difficult due to multiple rules, competing educational goals, and ever-evolving graduate medical education requirements. Despite this, schedules are typically created manually, consuming hours of work, producing schedules of varying quality, and yielding negative consequences for resident morale and learning. To determine whether computerized decision support can improve the construction of residency schedules, saving time and improving schedule quality. The Optimized Residency Scheduling Assistant was designed by a team from the University of Michigan Department of Industrial and Operations Engineering. It was implemented in the C.S. Mott Children's Hospital Pediatric Emergency Department in the 2012-2013 academic year. The 4 metrics of schedule quality that were compared between the 2010-2011 and 2012-2013 academic years were the incidence of challenging shift transitions, the incidence of shifts following continuity clinics, the total shift inequity, and the night shift inequity. All scheduling rules were successfully incorporated. Average schedule creation time fell from 22 to 28 hours to 4 to 6 hours per month, and 3 of 4 metrics of schedule quality significantly improved. For the implementation year, the incidence of challenging shift transitions decreased from 83 to 14 (P < .01); the incidence of postclinic shifts decreased from 72 to 32 (P < .01); and the SD of night shifts dropped by 55.6% (P < .01). This automated shift scheduling system improves the current manual scheduling process, reducing time spent and improving schedule quality. Embracing such automated tools can benefit residency programs with shift-based scheduling needs.

  20. Use of regularly scheduled albuterol treatment in asthma: genotype-stratified, randomised, placebo-controlled cross-over trial.

    PubMed

    Israel, Elliot; Chinchilli, Vernon M; Ford, Jean G; Boushey, Homer A; Cherniack, Reuben; Craig, Timothy J; Deykin, Aaron; Fagan, Joanne K; Fahy, John V; Fish, James; Kraft, Monica; Kunselman, Susan J; Lazarus, Stephen C; Lemanske, Robert F; Liggett, Stephen B; Martin, Richard J; Mitra, Nandita; Peters, Stephen P; Silverman, Eric; Sorkness, Christine A; Szefler, Stanley J; Wechsler, Michael E; Weiss, Scott T; Drazen, Jeffrey M

    The issue of whether regular use of an inhaled beta2-adrenergic agonist worsens airflow and clinical outcomes in asthma is controversial. Retrospective studies have suggested that adverse effects occur in patients with a genetic polymorphism that results in homozygosity for arginine (Arg/Arg), rather than glycine (Gly/Gly), at aminoacid residue 16 of the beta2-adrenergic receptor. However, the existence of any genotype-dependent difference has not been tested in a prospective clinical trial. Patients with mild asthma, not using a controller medication, were enrolled in pairs matched for forced expiratory volume in 1 s (FEV1) according to whether they had the Arg/Arg (n=37; four of 41 matches withdrew before randomisation) or Gly/Gly (n=41) genotype. Regularly scheduled treatment with albuterol or placebo was given in a masked, cross-over design, for 16-week periods. During the study, as-needed albuterol use was discontinued and ipratropium bromide was used as needed. Morning peak expiratory flow rate (PEFR) was the primary outcome variable. The primary comparisons were between treatment period for each genotype; the secondary outcome was a treatment by genotype effect. Analyses were by intention to treat. During the run-in period, when albuterol use was kept to a minimum, patients with the Arg/Arg genotype had an increase in morning PEFR of 23 L/min (p=0.0162); the change in patients with the Gly/Gly genotype was not significant (2 L/min; p=0.8399). During randomised treatment, patients with the Gly/Gly genotype had an increase in morning PEFR during treatment with regularly scheduled albuterol compared with placebo (14 L/min [95% CI 3 to 25]; p=0.0175). By contrast, patients with the Arg/Arg genotype had lower morning PEFR during treatment with albuterol than during the placebo period, when albuterol use was limited (-10 L/min [-19 to -2]; p=0.0209). The genotype-attributable treatment difference was therefore -24 L/min (-37 to -12; p=0.0003). There were similar

  1. Dedicated heterogeneous node scheduling including backfill scheduling

    DOEpatents

    Wood, Robert R [Livermore, CA; Eckert, Philip D [Livermore, CA; Hommes, Gregg [Pleasanton, CA

    2006-07-25

    A method and system for job backfill scheduling dedicated heterogeneous nodes in a multi-node computing environment. Heterogeneous nodes are grouped into homogeneous node sub-pools. For each sub-pool, a free node schedule (FNS) is created so that the number of to chart the free nodes over time. For each prioritized job, using the FNS of sub-pools having nodes useable by a particular job, to determine the earliest time range (ETR) capable of running the job. Once determined for a particular job, scheduling the job to run in that ETR. If the ETR determined for a lower priority job (LPJ) has a start time earlier than a higher priority job (HPJ), then the LPJ is scheduled in that ETR if it would not disturb the anticipated start times of any HPJ previously scheduled for a future time. Thus, efficient utilization and throughput of such computing environments may be increased by utilizing resources otherwise remaining idle.

  2. Chemotherapy appointment scheduling under uncertainty using mean-risk stochastic integer programming.

    PubMed

    Alvarado, Michelle; Ntaimo, Lewis

    2018-03-01

    Oncology clinics are often burdened with scheduling large volumes of cancer patients for chemotherapy treatments under limited resources such as the number of nurses and chairs. These cancer patients require a series of appointments over several weeks or months and the timing of these appointments is critical to the treatment's effectiveness. Additionally, the appointment duration, the acuity levels of each appointment, and the availability of clinic nurses are uncertain. The timing constraints, stochastic parameters, rising treatment costs, and increased demand of outpatient oncology clinic services motivate the need for efficient appointment schedules and clinic operations. In this paper, we develop three mean-risk stochastic integer programming (SIP) models, referred to as SIP-CHEMO, for the problem of scheduling individual chemotherapy patient appointments and resources. These mean-risk models are presented and an algorithm is devised to improve computational speed. Computational results were conducted using a simulation model and results indicate that the risk-averse SIP-CHEMO model with the expected excess mean-risk measure can decrease patient waiting times and nurse overtime when compared to deterministic scheduling algorithms by 42 % and 27 %, respectively.

  3. Optimizing Chemotherapy Dose and Schedule by Norton-Simon Mathematical Modeling

    PubMed Central

    Traina, Tiffany A.; Dugan, Ute; Higgins, Brian; Kolinsky, Kenneth; Theodoulou, Maria; Hudis, Clifford A.; Norton, Larry

    2011-01-01

    Background To hasten and improve anticancer drug development, we created a novel approach to generating and analyzing preclinical dose-scheduling data so as to optimize benefit-to-toxicity ratios. Methods We applied mathematical methods based upon Norton-Simon growth kinetic modeling to tumor-volume data from breast cancer xenografts treated with capecitabine (Xeloda®, Roche) at the conventional schedule of 14 days of treatment followed by a 7-day rest (14 - 7). Results The model predicted that 7 days of treatment followed by a 7-day rest (7 - 7) would be superior. Subsequent preclinical studies demonstrated that this biweekly capecitabine schedule allowed for safe delivery of higher daily doses, improved tumor response, and prolonged animal survival. Conclusions We demonstrated that the application of Norton-Simon modeling to the design and analysis of preclinical data predicts an improved capecitabine dosing schedule in xenograft models. This method warrants further investigation and application in clinical drug development. PMID:20519801

  4. 77 FR 64848 - Proposed Collection; Comment Request for Form 1120S, Schedule D, Schedule K-1, and Schedule M-3

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-23

    ... 1120S, Schedule D, Schedule K-1, and Schedule M-3 AGENCY: Internal Revenue Service (IRS), Treasury... (Loss) Reconciliation for S Corporations With Total Assets of $10 Million or More, and Schedule K-1... Corporation, Schedule D (Form 1120S), Capital Gains and Losses and Built-in Gains, Schedule K-1 (Form 1120S...

  5. Space communications scheduler: A rule-based approach to adaptive deadline scheduling

    NASA Technical Reports Server (NTRS)

    Straguzzi, Nicholas

    1990-01-01

    Job scheduling is a deceptively complex subfield of computer science. The highly combinatorial nature of the problem, which is NP-complete in nearly all cases, requires a scheduling program to intelligently transverse an immense search tree to create the best possible schedule in a minimal amount of time. In addition, the program must continually make adjustments to the initial schedule when faced with last-minute user requests, cancellations, unexpected device failures, quests, cancellations, unexpected device failures, etc. A good scheduler must be quick, flexible, and efficient, even at the expense of generating slightly less-than-optimal schedules. The Space Communication Scheduler (SCS) is an intelligent rule-based scheduling system. SCS is an adaptive deadline scheduler which allocates modular communications resources to meet an ordered set of user-specified job requests on board the NASA Space Station. SCS uses pattern matching techniques to detect potential conflicts through algorithmic and heuristic means. As a result, the system generates and maintains high density schedules without relying heavily on backtracking or blind search techniques. SCS is suitable for many common real-world applications.

  6. Scheduling Results for the THEMIS Observation Scheduling Tool

    NASA Technical Reports Server (NTRS)

    Mclaren, David; Rabideau, Gregg; Chien, Steve; Knight, Russell; Anwar, Sadaat; Mehall, Greg; Christensen, Philip

    2011-01-01

    We describe a scheduling system intended to assist in the development of instrument data acquisitions for the THEMIS instrument, onboard the Mars Odyssey spacecraft, and compare results from multiple scheduling algorithms. This tool creates observations of both (a) targeted geographical regions of interest and (b) general mapping observations, while respecting spacecraft constraints such as data volume, observation timing, visibility, lighting, season, and science priorities. This tool therefore must address both geometric and state/timing/resource constraints. We describe a tool that maps geometric polygon overlap constraints to set covering constraints using a grid-based approach. These set covering constraints are then incorporated into a greedy optimization scheduling algorithm incorporating operations constraints to generate feasible schedules. The resultant tool generates schedules of hundreds of observations per week out of potential thousands of observations. This tool is currently under evaluation by the THEMIS observation planning team at Arizona State University.

  7. Scheduling techniques in the Request Oriented Scheduling Engine (ROSE)

    NASA Technical Reports Server (NTRS)

    Zoch, David R.

    1991-01-01

    Scheduling techniques in the ROSE are presented in the form of the viewgraphs. The following subject areas are covered: agenda; ROSE summary and history; NCC-ROSE task goals; accomplishments; ROSE timeline manager; scheduling concerns; current and ROSE approaches; initial scheduling; BFSSE overview and example; and summary.

  8. Interference Cognizant Network Scheduling

    NASA Technical Reports Server (NTRS)

    Hall, Brendan (Inventor); Bonk, Ted (Inventor); DeLay, Benjamin F. (Inventor); Varadarajan, Srivatsan (Inventor); Smithgall, William Todd (Inventor)

    2017-01-01

    Systems and methods for interference cognizant network scheduling are provided. In certain embodiments, a method of scheduling communications in a network comprises identifying a bin of a global timeline for scheduling an unscheduled virtual link, wherein a bin is a segment of the timeline; identifying a pre-scheduled virtual link in the bin; and determining if the pre-scheduled and unscheduled virtual links share a port. In certain embodiments, if the unscheduled and pre-scheduled virtual links don't share a port, scheduling transmission of the unscheduled virtual link to overlap with the scheduled transmission of the pre-scheduled virtual link; and if the unscheduled and pre-scheduled virtual links share a port: determining a start time delay for the unscheduled virtual link based on the port; and scheduling transmission of the unscheduled virtual link in the bin based on the start time delay to overlap part of the scheduled transmission of the pre-scheduled virtual link.

  9. DSN Scheduling Engine

    NASA Technical Reports Server (NTRS)

    Clement, Bradley; Johnston, Mark; Wax, Allan; Chouinard, Caroline

    2008-01-01

    The DSN (Deep Space Network) Scheduling Engine targets all space missions that use DSN services. It allows clients to issue scheduling, conflict identification, conflict resolution, and status requests in XML over a Java Message Service interface. The scheduling requests may include new requirements that represent a set of tracks to be scheduled under some constraints. This program uses a heuristic local search to schedule a variety of schedule requirements, and is being infused into the Service Scheduling Assembly, a mixed-initiative scheduling application. The engine resolves conflicting schedules of resource allocation according to a range of existing and possible requirement specifications, including optional antennas; start of track and track duration ranges; periodic tracks; locks on track start, duration, and allocated antenna; MSPA (multiple spacecraft per aperture); arraying/VLBI (very long baseline interferometry)/delta DOR (differential one-way ranging); continuous tracks; segmented tracks; gap-to-track ratio; and override or block-out of requirements. The scheduling models now include conflict identification for SOA(start of activity), BOT (beginning of track), RFI (radio frequency interference), and equipment constraints. This software will search through all possible allocations while providing a best-effort solution at any time. The engine reschedules to accommodate individual emergency tracks in 0.2 second, and emergency antenna downtime in 0.2 second. The software handles doubling of one mission's track requests over one week (to 42 total) in 2.7 seconds. Further tests will be performed in the context of actual schedules.

  10. 40 CFR 268.13 - Schedule for wastes identified or listed after November 8, 1984.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... AGENCY (CONTINUED) SOLID WASTES (CONTINUED) LAND DISPOSAL RESTRICTIONS Schedule for Land Disposal Prohibition and Establishment of Treatment Standards § 268.13 Schedule for wastes identified or listed after... 40 Protection of Environment 27 2011-07-01 2011-07-01 false Schedule for wastes identified or...

  11. 40 CFR 268.13 - Schedule for wastes identified or listed after November 8, 1984.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... AGENCY (CONTINUED) SOLID WASTES (CONTINUED) LAND DISPOSAL RESTRICTIONS Schedule for Land Disposal Prohibition and Establishment of Treatment Standards § 268.13 Schedule for wastes identified or listed after... 40 Protection of Environment 28 2013-07-01 2013-07-01 false Schedule for wastes identified or...

  12. 40 CFR 268.13 - Schedule for wastes identified or listed after November 8, 1984.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... AGENCY (CONTINUED) SOLID WASTES (CONTINUED) LAND DISPOSAL RESTRICTIONS Schedule for Land Disposal Prohibition and Establishment of Treatment Standards § 268.13 Schedule for wastes identified or listed after... 40 Protection of Environment 26 2010-07-01 2010-07-01 false Schedule for wastes identified or...

  13. NASA scheduling technologies

    NASA Technical Reports Server (NTRS)

    Adair, Jerry R.

    1994-01-01

    This paper is a consolidated report on ten major planning and scheduling systems that have been developed by the National Aeronautics and Space Administration (NASA). A description of each system, its components, and how it could be potentially used in private industry is provided in this paper. The planning and scheduling technology represented by the systems ranges from activity based scheduling employing artificial intelligence (AI) techniques to constraint based, iterative repair scheduling. The space related application domains in which the systems have been deployed vary from Space Shuttle monitoring during launch countdown to long term Hubble Space Telescope (HST) scheduling. This paper also describes any correlation that may exist between the work done on different planning and scheduling systems. Finally, this paper documents the lessons learned from the work and research performed in planning and scheduling technology and describes the areas where future work will be conducted.

  14. The GBT Dynamic Scheduling System: A New Scheduling Paradigm

    NASA Astrophysics Data System (ADS)

    O'Neil, K.; Balser, D.; Bignell, C.; Clark, M.; Condon, J.; McCarty, M.; Marganian, P.; Shelton, A.; Braatz, J.; Harnett, J.; Maddalena, R.; Mello, M.; Sessoms, E.

    2009-09-01

    The Robert C. Byrd Green Bank Telescope (GBT) is implementing a new Dynamic Scheduling System (DSS) designed to maximize the observing efficiency of the telescope while ensuring that none of the flexibility and ease of use of the GBT is harmed and that the data quality of observations is not adversely affected. To accomplish this, the GBT DSS is implementing a dynamic scheduling system which schedules observers, rather than running scripts. The DSS works by breaking each project into one or more sessions which have associated observing criteria such as RA, Dec, and frequency. Potential observers may also enter dates when members of their team will not be available for either on-site or remote observing. The scheduling algorithm uses those data, along with the predicted weather, to determine the most efficient schedule for the GBT. The DSS provides all observers at least 24 hours notice of their upcoming observing. In the uncommon (< 20%) case where the actual weather does not match the predictions, a backup project, chosen from the database, is run instead. Here we give an overview of the GBT DSS project, including the ranking and scheduling algorithms for the sessions, the scheduling probabilities generation, the web framework for the system, and an overview of the results from the beta testing which were held from June - September, 2008.

  15. Considerations for Using an Incremental Scheduler for Human Exploration Task Scheduling

    NASA Technical Reports Server (NTRS)

    Jaap, John; Phillips, Shaun

    2005-01-01

    As humankind embarks on longer space missions farther from home, the requirements and environments for scheduling the activities performed on these missions are changing. As we begin to prepare for these missions it is appropriate to evaluate the merits and applicability of the different types of scheduling engines. Scheduling engines temporally arrange tasks onto a timeline so that all constraints and objectives are met and resources are not overbooked. Scheduling engines used to schedule space missions fall into three general categories: batch, mixed-initiative, and incremental. This paper presents an assessment of the engine types, a discussion of the impact of human exploration of the moon and Mars on planning and scheduling, and the applicability of the different types of scheduling engines. This paper will pursue the hypothesis that incremental scheduling engines may have a place in the new environment; they have the potential to reduce cost, to improve the satisfaction of those who execute or benefit from a particular timeline (the customers), and to allow astronauts to plan their own tasks.

  16. Schedule Risk Assessment

    NASA Technical Reports Server (NTRS)

    Smith, Greg

    2003-01-01

    Schedule risk assessments determine the likelihood of finishing on time. Each task in a schedule has a varying degree of probability of being finished on time. A schedule risk assessment quantifies these probabilities by assigning values to each task. This viewgraph presentation contains a flow chart for conducting a schedule risk assessment, and profiles applicable several methods of data analysis.

  17. Protocols for distributive scheduling

    NASA Technical Reports Server (NTRS)

    Richards, Stephen F.; Fox, Barry

    1993-01-01

    The increasing complexity of space operations and the inclusion of interorganizational and international groups in the planning and control of space missions lead to requirements for greater communication, coordination, and cooperation among mission schedulers. These schedulers must jointly allocate scarce shared resources among the various operational and mission oriented activities while adhering to all constraints. This scheduling environment is complicated by such factors as the presence of varying perspectives and conflicting objectives among the schedulers, the need for different schedulers to work in parallel, and limited communication among schedulers. Smooth interaction among schedulers requires the use of protocols that govern such issues as resource sharing, authority to update the schedule, and communication of updates. This paper addresses the development and characteristics of such protocols and their use in a distributed scheduling environment that incorporates computer-aided scheduling tools. An example problem is drawn from the domain of space shuttle mission planning.

  18. Analysis of Issues for Project Scheduling by Multiple, Dispersed Schedulers (distributed Scheduling) and Requirements for Manual Protocols and Computer-based Support

    NASA Technical Reports Server (NTRS)

    Richards, Stephen F.

    1991-01-01

    Although computerized operations have significant gains realized in many areas, one area, scheduling, has enjoyed few benefits from automation. The traditional methods of industrial engineering and operations research have not proven robust enough to handle the complexities associated with the scheduling of realistic problems. To address this need, NASA has developed the computer-aided scheduling system (COMPASS), a sophisticated, interactive scheduling tool that is in wide-spread use within NASA and the contractor community. Therefore, COMPASS provides no explicit support for the large class of problems in which several people, perhaps at various locations, build separate schedules that share a common pool of resources. This research examines the issue of distributing scheduling, as applied to application domains characterized by the partial ordering of tasks, limited resources, and time restrictions. The focus of this research is on identifying issues related to distributed scheduling, locating applicable problem domains within NASA, and suggesting areas for ongoing research. The issues that this research identifies are goals, rescheduling requirements, database support, the need for communication and coordination among individual schedulers, the potential for expert system support for scheduling, and the possibility of integrating artificially intelligent schedulers into a network of human schedulers.

  19. Conflict-Aware Scheduling Algorithm

    NASA Technical Reports Server (NTRS)

    Wang, Yeou-Fang; Borden, Chester

    2006-01-01

    conflict-aware scheduling algorithm is being developed to help automate the allocation of NASA s Deep Space Network (DSN) antennas and equipment that are used to communicate with interplanetary scientific spacecraft. The current approach for scheduling DSN ground resources seeks to provide an equitable distribution of tracking services among the multiple scientific missions and is very labor intensive. Due to the large (and increasing) number of mission requests for DSN services, combined with technical and geometric constraints, the DSN is highly oversubscribed. To help automate the process, and reduce the DSN and spaceflight project labor effort required for initiating, maintaining, and negotiating schedules, a new scheduling algorithm is being developed. The scheduling algorithm generates a "conflict-aware" schedule, where all requests are scheduled based on a dynamic priority scheme. The conflict-aware scheduling algorithm allocates all requests for DSN tracking services while identifying and maintaining the conflicts to facilitate collaboration and negotiation between spaceflight missions. These contrast with traditional "conflict-free" scheduling algorithms that assign tracks that are not in conflict and mark the remainder as unscheduled. In the case where full schedule automation is desired (based on mission/event priorities, fairness, allocation rules, geometric constraints, and ground system capabilities/ constraints), a conflict-free schedule can easily be created from the conflict-aware schedule by removing lower priority items that are in conflict.

  20. Automated telescope scheduling

    NASA Technical Reports Server (NTRS)

    Johnston, Mark D.

    1988-01-01

    With the ever increasing level of automation of astronomical telescopes the benefits and feasibility of automated planning and scheduling are becoming more apparent. Improved efficiency and increased overall telescope utilization are the most obvious goals. Automated scheduling at some level has been done for several satellite observatories, but the requirements on these systems were much less stringent than on modern ground or satellite observatories. The scheduling problem is particularly acute for Hubble Space Telescope: virtually all observations must be planned in excruciating detail weeks to months in advance. Space Telescope Science Institute has recently made significant progress on the scheduling problem by exploiting state-of-the-art artificial intelligence software technology. What is especially interesting is that this effort has already yielded software that is well suited to scheduling groundbased telescopes, including the problem of optimizing the coordinated scheduling of more than one telescope.

  1. Submarine watch schedules: underway evaluation of rotating (contemporary) and compressed (alternative) schedules.

    PubMed

    Duplessis, C A; Miller, J C; Crepeau, L J; Osborn, C M; Dyche, J

    2007-01-01

    With a desire to increase health, cognitive performance effectiveness, and quality of life for submarine watch-standers underway, we performed an evaluation comparing an alternative, compressed-work (ALT) schedule, designed to enhance circadian rhythm entrainment and sleep hygiene, to the contemporary submarine (SUB) forward rotating schedule, aboard the ballistic-missile submarine, USS Henry M. Jackson (SSBN-730 Gold). We assessed a compressed close-6 watch-schedule ("ALT") relative to the existing backward rotating 6-hr on, 12-hr off 18-hr watch schedule ("SUB") employed underway aboard submarines. We monitored 40 subjects' sleep, and temperature and salivary cortisol from 10 of the 40 for approximately two weeks on each respective schedule underway. The cortisol cosinor mesors (midline estimating statistic of rhythm), and amplitudes did not differ significantly between conditions. The temperature cosinor mesors, and the cosinor amplitude were not significantly different, while the cosine curve fit accounted for significantly more variance in the ALT condition than in the SUB condition. The SUB schedule garnered significantly more sleep (7.1 +/- 0.2 hours) than that of the ALTMID schedule (6.3 +/- 0.3 hours). Surveys revealed that 52% of respondents preferred the SUB schedule, 15% preferred the ALT, and 33% were either indifferent or submitted uninterpretable surveys. The ALT schedule was not superior to the existing SUB schedule by physiological or subjective measures and was incompatible to accommodating operational constraints.

  2. Web Publishing Schedule

    EPA Pesticide Factsheets

    Section 207(f)(2) of the E-Gov Act requires federal agencies to develop an inventory and establish a schedule of information to be published on their Web sites, make those schedules available for public comment. To post the schedules on the web site.

  3. Schedule Risk Assessment

    NASA Technical Reports Server (NTRS)

    Smith, Greg

    2003-01-01

    Schedule Risk Assessment needs to determine the probability of finishing on or before a given point in time. Task in a schedule should reflect the "most likely" duration for each task. IN reality, each task is different and has a varying degree of probability of finishing within or after the duration specified. Schedule risk assessment attempt to quantify these probabilities by assigning values to each task. Bridges the gap between CPM scheduling and the project's need to know the likelihood of "when".

  4. Effect of treatment in fractionated schedules with the combination of x-irradiation and six cytotoxic drugs on the RIF-1 tumor and normal mouse skin

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lelieveld, P.; Scoles, M.A.; Brown, J.M.

    1985-01-01

    RIF-1 tumors, implanted syngeneically in the gastrocnemius muscles of the right hind legs of C3H/Km mice, were treated either with X ray alone, drug alone, or drug and X ray combined. The drugs tested were bleomycin, BCNU, cis-diamminedichloro platinum, adriamycin, cyclophosphamide, and actinomycin-D. All drugs were administered either in the maximum tolerated dose or a dose that causes minimal tumor growth delay. Both drugs and X rays were administered either as a single dose or in five daily fractions. In addition to the single modality controls, seven different schedules of combined modalities were tested. Tumors were measured periodically after treatmentmore » in order that the day at which each tumor reached 4 times its initial cross-sectional area, i.e., its size at the time of treatment, could be determined. The effect of treatment on tumors was based upon excess growth delay (GD), i.e., T400% (treated)-T400% (untreated control). Treatment effects for the same combined modality schedules were also determined for normal skin, using the early skin reaction as an endpoint. Dose effect factors (DEF) were computed for all combined modality schedules and were based upon calculated radiation dose equivalents. We also calculated supra-additivity ratios, SR/sub I/ and SR/sub II/, therapeutic gain factors and adjusted therapeutic gain factors. The only drugs to produce significant supra-additivity with X rays were cis-Pt and cyclo.« less

  5. Schedule Matters: Understanding the Relationship between Schedule Delays and Costs on Overruns

    NASA Technical Reports Server (NTRS)

    Majerowicz, Walt; Shinn, Stephen A.

    2016-01-01

    This paper examines the relationship between schedule delays and cost overruns on complex projects. It is generally accepted by many project practitioners that cost overruns are directly related to schedule delays. But what does "directly related to" actually mean? Some reasons or root causes for schedule delays and associated cost overruns are obvious, if only in hindsight. For example, unrealistic estimates, supply chain difficulties, insufficient schedule margin, technical problems, scope changes, or the occurrence of risk events can negatively impact schedule performance. Other factors driving schedule delays and cost overruns may be less obvious and more difficult to quantify. Examples of these less obvious factors include project complexity, flawed estimating assumptions, over-optimism, political factors, "black swan" events, or even poor leadership and communication. Indeed, is it even possible the schedule itself could be a source of delay and subsequent cost overrun? Through literature review, surveys of project practitioners, and the authors' own experience on NASA programs and projects, the authors will categorize and examine the various factors affecting the relationship between project schedule delays and cost growth. The authors will also propose some ideas for organizations to consider to help create an awareness of the factors which could cause or influence schedule delays and associated cost growth on complex projects.

  6. Aspects of job scheduling

    NASA Technical Reports Server (NTRS)

    Phillips, K.

    1976-01-01

    A mathematical model for job scheduling in a specified context is presented. The model uses both linear programming and combinatorial methods. While designed with a view toward optimization of scheduling of facility and plant operations at the Deep Space Communications Complex, the context is sufficiently general to be widely applicable. The general scheduling problem including options for scheduling objectives is discussed and fundamental parameters identified. Mathematical algorithms for partitioning problems germane to scheduling are presented.

  7. Operations research methods improve chemotherapy patient appointment scheduling.

    PubMed

    Santibáñez, Pablo; Aristizabal, Ruben; Puterman, Martin L; Chow, Vincent S; Huang, Wenhai; Kollmannsberger, Christian; Nordin, Travis; Runzer, Nancy; Tyldesley, Scott

    2012-12-01

    Clinical complexity, scheduling restrictions, and outdated manual booking processes resulted in frequent clerical rework, long waitlists for treatment, and late appointment notification for patients at a chemotherapy clinic in a large cancer center in British Columbia, Canada. A 17-month study was conducted to address booking, scheduling and workload issues and to develop, implement, and evaluate solutions. A review of scheduling practices included process observation and mapping, analysis of historical appointment data, creation of a new performance metric (final appointment notification lead time), and a baseline patient satisfaction survey. Process improvement involved discrete event simulation to evaluate alternative booking practice scenarios, development of an optimization-based scheduling tool to improve scheduling efficiency, and change management for implementation of process changes. Results were evaluated through analysis of appointment data, a follow-up patient survey, and staff surveys. Process review revealed a two-stage scheduling process. Long waitlists and late notification resulted from an inflexible first-stage process. The second-stage process was time consuming and tedious. After a revised, more flexible first-stage process and an automated second-stage process were implemented, the median percentage of appointments exceeding the final appointment notification lead time target of one week was reduced by 57% and median waitlist size decreased by 83%. Patient surveys confirmed increased satisfaction while staff feedback reported reduced stress levels. Significant operational improvements can be achieved through process redesign combined with operations research methods.

  8. Single-Pass Serial Scheduling Heuristic for Eglin AFB Range Services Division Schedule

    DTIC Science & Technology

    2009-06-01

    scheduling tool for this RCPSP. Research on a schedule improvement metaheuristic and coding of the complete algorithm is required before it can be...a schedule better by applying metaheuristic improvement algorithms to a feasible schedule after it is created. 2.5.1. Greedy Algorithm The...next available position, the algorithm will not utilize all the available range time and manpower. An improvement metaheuristic is required to

  9. Dose Schedule Optimization and the Pharmacokinetic Driver of Neutropenia

    PubMed Central

    Patel, Mayankbhai; Palani, Santhosh; Chakravarty, Arijit; Yang, Johnny; Shyu, Wen Chyi; Mettetal, Jerome T.

    2014-01-01

    Toxicity often limits the utility of oncology drugs, and optimization of dose schedule represents one option for mitigation of this toxicity. Here we explore the schedule-dependency of neutropenia, a common dose-limiting toxicity. To this end, we analyze previously published mathematical models of neutropenia to identify a pharmacokinetic (PK) predictor of the neutrophil nadir, and confirm this PK predictor in an in vivo experimental system. Specifically, we find total AUC and Cmax are poor predictors of the neutrophil nadir, while a PK measure based on the moving average of the drug concentration correlates highly with neutropenia. Further, we confirm this PK parameter for its ability to predict neutropenia in vivo following treatment with different doses and schedules. This work represents an attempt at mechanistically deriving a fundamental understanding of the underlying pharmacokinetic drivers of neutropenia, and provides insights that can be leveraged in a translational setting during schedule selection. PMID:25360756

  10. Scheduling Nonconsumable Resources

    NASA Technical Reports Server (NTRS)

    Porta, Harry J.

    1990-01-01

    Users manual describes computer program SWITCH that schedules use of resources - by appliances switched on and off and use resources while they are on. Plans schedules according to predetermined goals; revises schedules when new goals imposed. Program works by depth-first searching with strict chronological back-tracking. Proceeds to evaluate alternatives as necessary, sometimes interacting with user.

  11. Significance of the Bacteriophage Treatment Schedule in Reducing Salmonella Colonization of Poultry

    PubMed Central

    Bardina, Carlota; Spricigo, Denis A.; Cortés, Pilar

    2012-01-01

    Salmonella remains the major cause of food-borne diseases worldwide, with chickens known to be the main reservoir for this zoonotic pathogen. Among the many approaches to reducing Salmonella colonization of broilers, bacteriophage offers several advantages. In this study, three bacteriophages (UAB_Phi20, UAB_Phi78, and UAB_Phi87) obtained from our collection that exhibited a broad host range against Salmonella enterica serovar Enteritidis and Salmonella enterica serovar Typhimurium were characterized with respect to morphology, genome size, and restriction patterns. A cocktail composed of the three bacteriophages was more effective in promoting the lysis of S. Enteritidis and S. Typhimurium cultures than any of the three bacteriophages alone. In addition, the cocktail was able to lyse the Salmonella enterica serovars Virchow, Hadar, and Infantis. The effectiveness of the bacteriophage cocktail in reducing the concentration of S. Typhimurium was tested in two animal models using different treatment schedules. In the mouse model, 50% survival was obtained when the cocktail was administered simultaneously with bacterial infection and again at 6, 24, and 30 h postinfection. Likewise, in the White Leghorn chicken specific-pathogen-free (SPF) model, the best results, defined as a reduction of Salmonella concentration in the chicken cecum, were obtained when the bacteriophage cocktail was administered 1 day before or just after bacterial infection and then again on different days postinfection. Our results show that frequent treatment of the chickens with bacteriophage, and especially prior to colonization of the intestinal tract by Salmonella, is required to achieve effective bacterial reduction over time. PMID:22773654

  12. A Generic Expert Scheduling System Architecture and Toolkit: GUESS (Generically Used Expert Scheduling System)

    NASA Technical Reports Server (NTRS)

    Liebowitz, Jay; Krishnamurthy, Vijaya; Rodens, Ira; Houston, Chapman; Liebowitz, Alisa; Baek, Seung; Radko, Joe; Zeide, Janet

    1996-01-01

    Scheduling has become an increasingly important element in today's society and workplace. Within the NASA environment, scheduling is one of the most frequently performed and challenging functions. Towards meeting NASA's scheduling needs, a research version of a generic expert scheduling system architecture and toolkit has been developed. This final report describes the development and testing of GUESS (Generically Used Expert Scheduling System).

  13. Operational VGOS Scheduling

    NASA Astrophysics Data System (ADS)

    Searle, Anthony; Petrachenko, Bill

    2016-12-01

    The VLBI Global Observing System (VGOS) has been designed to take advantage of advances in data recording speeds and storage capacity, allowing for smaller and faster antennas, wider bandwidths, and shorter observation durations. Here, schedules for a ``realistic" VGOS network, frequency sequences, and expanded source lists are presented using a new source-based scheduling algorithm. The VGOS aim for continuous observations presents new operational challenges. As the source-based strategy is independent of the observing network, there are operational advantages which allow for more flexible scheduling of continuous VLBI observations. Using VieVS, simulations of several schedules are presented and compared with previous VGOS studies.

  14. Enhancing the activity of cannabidiol and other cannabinoids in vitro through modifications to drug combinations and treatment schedules.

    PubMed

    Scott, Katherine Ann; Shah, Sini; Dalgleish, Angus George; Liu, Wai Man

    2013-10-01

    Cannabinoids are the bioactive components of the Cannabis plant that display a diverse range of therapeutic qualities. We explored the activity of six cannabinoids, used both alone and in combination in leukaemic cells. Cannabinoids were cytostatic and caused a simultaneous arrest at all phases of the cell cycle. Re-culturing pre-treated cells in drug-free medium resulted in dramatic reductions in cell viability. Furthermore, combining cannabinoids was not antagonistic. We suggest that the activities of some cannabinoids are influenced by treatment schedules; therefore, it is important to carefully select the most appropriate strategy in order to maximise their efficacy.

  15. 20 CFR 10.805 - What services are covered by the OWCP fee schedule?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... schedule of maximum allowable charges does not apply to charges for services provided in nursing homes, but it does apply to charges for treatment furnished in a nursing home by a physician or other medical... covered by the OWCP fee schedule? (a) Payment for medical and other health services furnished by...

  16. A treatment comparison study of a photo activity schedule and Social Stories for teaching social skills to children with Autism Spectrum Disorder: brief report.

    PubMed

    Daneshvar, Sabrina D; Charlop, Marjorie H; Berry Malmberg, Debra

    2018-05-21

    To compare the efficacy of two procedures, a photo activity schedule intervention and Social Stories, to teach social skills to four children diagnosed with Autism Spectrum Disorder (ASD). An adapted alternating treatments design with an additional multiple baseline control was used, and two social skills were targeted for each of the four participants, one under each intervention condition. Results indicated that all four participants learned the target social behaviours with the photo activity schedule intervention, but did not learn target social behaviours with Social Stories. Findings support the use of a photo activity intervention for teaching social skillsto children with ASD; we discuss the implications of inconsistent findings of effectiveness of Social Stories.

  17. Projecting Future Scheduled Airline Demand, Schedules and NGATS Benefits Using TSAM

    NASA Technical Reports Server (NTRS)

    Dollyhigh, Samuel; Smith, Jeremy; Viken, Jeff; Trani, Antonio; Baik, Hojong; Hinze, Nickolas; Ashiabor, Senanu

    2006-01-01

    The Transportation Systems Analysis Model (TSAM) developed by Virginia Tech s Air Transportation Systems Lab and NASA Langley can provide detailed analysis of the effects on the demand for air travel of a full range of NASA and FAA aviation projects. TSAM has been used to project the passenger demand for very light jet (VLJ) air taxi service, scheduled airline demand growth and future schedules, Next Generation Air Transportation System (NGATS) benefits, and future passenger revenues for the Airport and Airway Trust Fund. TSAM can project the resulting demand when new vehicles and/or technology is inserted into the long distance (100 or more miles one-way) transportation system, as well as, changes in demand as a result of fare yield increases or decreases, airport transit times, scheduled flight times, ticket taxes, reductions or increases in flight delays, and so on. TSAM models all long distance travel in the contiguous U.S. and determines the mode choice of the traveler based on detailed trip costs, travel time, schedule frequency, purpose of the trip (business or non-business), and household income level of the traveler. Demand is modeled at the county level, with an airport choice module providing up to three airports as part of the mode choice. Future enplanements at airports can be projected for different scenarios. A Fratar algorithm and a schedule generator are applied to generate future flight schedules. This paper presents the application of TSAM to modeling future scheduled air passenger demand and resulting airline schedules, the impact of NGATS goals and objectives on passenger demand, along with projections for passenger fee receipts for several scenarios for the FAA Airport and Airway Trust Fund.

  18. Second-order schedules of token reinforcement with pigeons: effects of fixed- and variable-ratio exchange schedules.

    PubMed

    Foster, T A; Hackenberg, T D; Vaidya, M

    2001-09-01

    Pigeons' key pecks produced food under second-order schedules of token reinforcement, with light-emitting diodes serving as token reinforcers. In Experiment 1, tokens were earned according to a fixed-ratio 50 schedule and were exchanged for food according to either fixed-ratio or variable-ratio exchange schedules, with schedule type varied across conditions. In Experiment 2, schedule type was varied within sessions using a multiple schedule. In one component, tokens were earned according to a fixed-ratio 50 schedule and exchanged according to a variable-ratio schedule. In the other component, tokens were earned according to a variable-ratio 50 schedule and exchanged according to a fixed-ratio schedule. In both experiments, the number of responses per exchange was varied parametrically across conditions, ranging from 50 to 400 responses. Response rates decreased systematically with increases in the fixed-ratio exchange schedules, but were much less affected by changes in the variable-ratio exchange schedules. Response rates were consistently higher under variable-ratio exchange schedules than tinder comparable fixed-ratio exchange schedules, especially at higher exchange ratios. These response-rate differences were due both to greater pre-ratio pausing and to lower local rates tinder the fixed-ratio exchange schedules. Local response rates increased with proximity to food under the higher fixed-ratio exchange schedules, indicative of discriminative control by the tokens.

  19. Scheduling the future NASA Space Network: Experiences with a flexible scheduling prototype

    NASA Technical Reports Server (NTRS)

    Happell, Nadine; Moe, Karen L.; Minnix, Jay

    1993-01-01

    NASA's Space Network (SN) provides telecommunications and tracking services to low earth orbiting spacecraft. One proposal for improving resource allocation and automating conflict resolution for the SN is the concept of flexible scheduling. In this concept, each Payload Operations Control Center (POCC) will possess a Space Network User POCC Interface (SNUPI) to support the development and management of flexible requests. Flexible requests express the flexibility, constraints, and repetitious nature of the user's communications requirements. Flexible scheduling is expected to improve SN resource utilization and user satisfaction, as well as reduce the effort to produce and maintain a schedule. A prototype testbed has been developed to better understand flexible scheduling as it applies to the SN. This testbed consists of a SNUPI workstation, an SN scheduler, and a flexible request language that conveys information between the two systems. All three are being evaluated by operations personnel. Benchmark testing is being conducted on the scheduler to quantify the productivity improvements achieved with flexible requests.

  20. DSN Resource Scheduling

    NASA Technical Reports Server (NTRS)

    Wang, Yeou-Fang; Baldwin, John

    2007-01-01

    TIGRAS is client-side software, which provides tracking-station equipment planning, allocation, and scheduling services to the DSMS (Deep Space Mission System). TIGRAS provides functions for schedulers to coordinate the DSN (Deep Space Network) antenna usage time and to resolve the resource usage conflicts among tracking passes, antenna calibrations, maintenance, and system testing activities. TIGRAS provides a fully integrated multi-pane graphical user interface for all scheduling operations. This is a great improvement over the legacy VAX VMS command line user interface. TIGRAS has the capability to handle all DSN resource scheduling aspects from long-range to real time. TIGRAS assists NASA mission operations for DSN tracking of station equipment resource request processes from long-range load forecasts (ten years or longer), to midrange, short-range, and real-time (less than one week) emergency tracking plan changes. TIGRAS can be operated by NASA mission operations worldwide to make schedule requests for the DSN station equipment.

  1. Constraint-based scheduling

    NASA Technical Reports Server (NTRS)

    Zweben, Monte

    1991-01-01

    The GERRY scheduling system developed by NASA Ames with assistance from the Lockheed Space Operations Company, and the Lockheed Artificial Intelligence Center, uses a method called constraint-based iterative repair. Using this technique, one encodes both hard rules and preference criteria into data structures called constraints. GERRY repeatedly attempts to improve schedules by seeking repairs for violated constraints. The system provides a general scheduling framework which is being tested on two NASA applications. The larger of the two is the Space Shuttle Ground Processing problem which entails the scheduling of all the inspection, repair, and maintenance tasks required to prepare the orbiter for flight. The other application involves power allocation for the NASA Ames wind tunnels. Here the system will be used to schedule wind tunnel tests with the goal of minimizing power costs. In this paper, we describe the GERRY system and its application to the Space Shuttle problem. We also speculate as to how the system would be used for manufacturing, transportation, and military problems.

  2. Constraint-based scheduling

    NASA Technical Reports Server (NTRS)

    Zweben, Monte

    1991-01-01

    The GERRY scheduling system developed by NASA Ames with assistance from the Lockheed Space Operations Company, and the Lockheed Artificial Intelligence Center, uses a method called constraint based iterative repair. Using this technique, one encodes both hard rules and preference criteria into data structures called constraints. GERRY repeatedly attempts to improve schedules by seeking repairs for violated constraints. The system provides a general scheduling framework which is being tested on two NASA applications. The larger of the two is the Space Shuttle Ground Processing problem which entails the scheduling of all inspection, repair, and maintenance tasks required to prepare the orbiter for flight. The other application involves power allocations for the NASA Ames wind tunnels. Here the system will be used to schedule wind tunnel tests with the goal of minimizing power costs. In this paper, we describe the GERRY system and its applications to the Space Shuttle problem. We also speculate as to how the system would be used for manufacturing, transportation, and military problems.

  3. Constraint-based scheduling

    NASA Technical Reports Server (NTRS)

    Zweben, Monte

    1993-01-01

    The GERRY scheduling system developed by NASA Ames with assistance from the Lockheed Space Operations Company, and the Lockheed Artificial Intelligence Center, uses a method called constraint-based iterative repair. Using this technique, one encodes both hard rules and preference criteria into data structures called constraints. GERRY repeatedly attempts to improve schedules by seeking repairs for violated constraints. The system provides a general scheduling framework which is being tested on two NASA applications. The larger of the two is the Space Shuttle Ground Processing problem which entails the scheduling of all the inspection, repair, and maintenance tasks required to prepare the orbiter for flight. The other application involves power allocation for the NASA Ames wind tunnels. Here the system will be used to schedule wind tunnel tests with the goal of minimizing power costs. In this paper, we describe the GERRY system and its application to the Space Shuttle problem. We also speculate as to how the system would be used for manufacturing, transportation, and military problems.

  4. Perceptions of randomized security schedules.

    PubMed

    Scurich, Nicholas; John, Richard S

    2014-04-01

    Security of infrastructure is a major concern. Traditional security schedules are unable to provide omnipresent coverage; consequently, adversaries can exploit predictable vulnerabilities to their advantage. Randomized security schedules, which randomly deploy security measures, overcome these limitations, but public perceptions of such schedules have not been examined. In this experiment, participants were asked to make a choice between attending a venue that employed a traditional (i.e., search everyone) or a random (i.e., a probability of being searched) security schedule. The absolute probability of detecting contraband was manipulated (i.e., 1/10, 1/4, 1/2) but equivalent between the two schedule types. In general, participants were indifferent to either security schedule, regardless of the probability of detection. The randomized schedule was deemed more convenient, but the traditional schedule was considered fairer and safer. There were no differences between traditional and random schedule in terms of perceived effectiveness or deterrence. Policy implications for the implementation and utilization of randomized schedules are discussed. © 2013 Society for Risk Analysis.

  5. A Comparison of Five Reinforcement Schedules for Use in Contingency Management-Based Treatment of Methamphetamine Abuse

    ERIC Educational Resources Information Center

    Roll, John M.; Huber, Alice; Sodano, Ruthlyn; Chudzynski, Joy E.; Moynier, Eugene; Shoptaw, Steve

    2006-01-01

    One variation of contingency management involves providing vouchers with monetary value for the provision of a biological sample indicating no recent drug use. These vouchers can be exchanged for goods or services. The schedule with which the vouchers are disbursed has been studied and results suggest that those schedules that incorporate…

  6. Composite Scheduling

    ERIC Educational Resources Information Center

    Childers, Gary L.; Ireland, Rebecca Weeks

    2005-01-01

    In education, there is no one best way to do anything. There are compelling reasons why some courses should be taught in longer segments of time, which the block schedule provides. There are also compelling reasons why some classes should be taught in shorter segments. At Watauga High School in Boone, North Carolina, an alternative schedule that…

  7. Automated Platform Management System Scheduling

    NASA Technical Reports Server (NTRS)

    Hull, Larry G.

    1990-01-01

    The Platform Management System was established to coordinate the operation of platform systems and instruments. The management functions are split between ground and space components. Since platforms are to be out of contact with the ground more than the manned base, the on-board functions are required to be more autonomous than those of the manned base. Under this concept, automated replanning and rescheduling, including on-board real-time schedule maintenance and schedule repair, are required to effectively and efficiently meet Space Station Freedom mission goals. In a FY88 study, we developed several promising alternatives for automated platform planning and scheduling. We recommended both a specific alternative and a phased approach to automated platform resource scheduling. Our recommended alternative was based upon use of exactly the same scheduling engine in both ground and space components of the platform management system. Our phased approach recommendation was based upon evolutionary development of the platform. In the past year, we developed platform scheduler requirements and implemented a rapid prototype of a baseline platform scheduler. Presently we are rehosting this platform scheduler rapid prototype and integrating the scheduler prototype into two Goddard Space Flight Center testbeds, as the ground scheduler in the Scheduling Concepts, Architectures, and Networks Testbed and as the on-board scheduler in the Platform Management System Testbed. Using these testbeds, we will investigate rescheduling issues, evaluate operational performance and enhance the platform scheduler prototype to demonstrate our evolutionary approach to automated platform scheduling. The work described in this paper was performed prior to Space Station Freedom rephasing, transfer of platform responsibility to Code E, and other recently discussed changes. We neither speculate on these changes nor attempt to predict the impact of the final decisions. As a consequence some of our

  8. How should periods without social interaction be scheduled? Children's preference for practical schedules of positive reinforcement.

    PubMed

    Luczynski, Kevin C; Hanley, Gregory P

    2014-01-01

    Several studies have shown that children prefer contingent reinforcement (CR) rather than yoked noncontingent reinforcement (NCR) when continuous reinforcement is programmed in the CR schedule. Preference has not, however, been evaluated for practical schedules that involve CR. In Study 1, we assessed 5 children's preference for obtaining social interaction via a multiple schedule (periods of fixed-ratio 1 reinforcement alternating with periods of extinction), a briefly signaled delayed reinforcement schedule, and an NCR schedule. The multiple schedule promoted the most efficient level of responding. In general, children chose to experience the multiple schedule and avoided the delay and NCR schedules, indicating that they preferred multiple schedules as the means to arrange practical schedules of social interaction. In Study 2, we evaluated potential controlling variables that influenced 1 child's preference for the multiple schedule and found that the strong positive contingency was the primary variable. © Society for the Experimental Analysis of Behavior.

  9. Reinforcement learning in scheduling

    NASA Technical Reports Server (NTRS)

    Dietterich, Tom G.; Ok, Dokyeong; Zhang, Wei; Tadepalli, Prasad

    1994-01-01

    The goal of this research is to apply reinforcement learning methods to real-world problems like scheduling. In this preliminary paper, we show that learning to solve scheduling problems such as the Space Shuttle Payload Processing and the Automatic Guided Vehicle (AGV) scheduling can be usefully studied in the reinforcement learning framework. We discuss some of the special challenges posed by the scheduling domain to these methods and propose some possible solutions we plan to implement.

  10. Minimizing metastatic risk in radiotherapy fractionation schedules

    NASA Astrophysics Data System (ADS)

    Badri, Hamidreza; Ramakrishnan, Jagdish; Leder, Kevin

    2015-11-01

    Metastasis is the process by which cells from a primary tumor disperse and form new tumors at distant anatomical locations. The treatment and prevention of metastatic cancer remains an extremely challenging problem. This work introduces a novel biologically motivated objective function to the radiation optimization community that takes into account metastatic risk instead of the status of the primary tumor. In this work, we consider the problem of developing fractionated irradiation schedules that minimize production of metastatic cancer cells while keeping normal tissue damage below an acceptable level. A dynamic programming framework is utilized to determine the optimal fractionation scheme. We evaluated our approach on a breast cancer case using the heart and the lung as organs-at-risk (OAR). For small tumor α /β values, hypo-fractionated schedules were optimal, which is consistent with standard models. However, for relatively larger α /β values, we found the type of schedule depended on various parameters such as the time when metastatic risk was evaluated, the α /β values of the OARs, and the normal tissue sparing factors. Interestingly, in contrast to standard models, hypo-fractionated and semi-hypo-fractionated schedules (large initial doses with doses tapering off with time) were suggested even with large tumor α/β values. Numerical results indicate the potential for significant reduction in metastatic risk.

  11. The comparison of predictive scheduling algorithms for different sizes of job shop scheduling problems

    NASA Astrophysics Data System (ADS)

    Paprocka, I.; Kempa, W. M.; Grabowik, C.; Kalinowski, K.; Krenczyk, D.

    2016-08-01

    In the paper a survey of predictive and reactive scheduling methods is done in order to evaluate how the ability of prediction of reliability characteristics influences over robustness criteria. The most important reliability characteristics are: Mean Time to Failure, Mean Time of Repair. Survey analysis is done for a job shop scheduling problem. The paper answers the question: what method generates robust schedules in the case of a bottleneck failure occurrence before, at the beginning of planned maintenance actions or after planned maintenance actions? Efficiency of predictive schedules is evaluated using criteria: makespan, total tardiness, flow time, idle time. Efficiency of reactive schedules is evaluated using: solution robustness criterion and quality robustness criterion. This paper is the continuation of the research conducted in the paper [1], where the survey of predictive and reactive scheduling methods is done only for small size scheduling problems.

  12. Automated Scheduling Via Artificial Intelligence

    NASA Technical Reports Server (NTRS)

    Biefeld, Eric W.; Cooper, Lynne P.

    1991-01-01

    Artificial-intelligence software that automates scheduling developed in Operations Mission Planner (OMP) research project. Software used in both generation of new schedules and modification of existing schedules in view of changes in tasks and/or available resources. Approach based on iterative refinement. Although project focused upon scheduling of operations of scientific instruments and other equipment aboard spacecraft, also applicable to such terrestrial problems as scheduling production in factory.

  13. A transportation-scheduling system for managing silvicultural projects

    Treesearch

    Jorge F. Valenzuela; H. Hakan Balci; Timothy McDonald

    2005-01-01

    A silvicultural project encompasses tasks such as sitelevel planning, regeneration, harvestin, and stand-tending treatments. an essential problem in managing silvicultural projects is to efficiently schedule the operations while considering project task due dates and costs of moving scarce resources to specific job locations. Transportation costs represent a...

  14. Production Scheduling for Rehabilitation Workshops.

    ERIC Educational Resources Information Center

    Hietala, David A.

    This publication examines production scheduling procedures for sheltered workshops. The manual includes three major sections: (1) the importance and benefits of production scheduling; (2) how-to information on performing basic scheduling in the workshop; and (3) answers to the question, What makes production scheduling work? The scheduling…

  15. Interactive computer aided shift scheduling.

    PubMed

    Gaertner, J

    2001-12-01

    This paper starts with a discussion of computer aided shift scheduling. After a brief review of earlier approaches, two conceptualizations of this field are introduced: First, shift scheduling as a field that ranges from extremely stable rosters at one pole to rather market-like approaches on the other pole. Unfortunately, already small alterations of a scheduling problem (e.g., the number of groups, the number of shifts) may call for rather different approaches and tools. Second, their environment shapes scheduling problems and scheduling has to be done within idiosyncratic organizational settings. This calls for the amalgamation of scheduling with other tasks (e.g., accounting) and for reflections whether better solutions might become possible by changes in the problem definition (e.g., other service levels, organizational changes). Therefore shift scheduling should be understood as a highly connected problem. Building upon these two conceptualizations, a few examples of software that ease scheduling in some areas of this field are given and future research questions are outlined.

  16. Linked Orders Improve Safety in Scheduling and Administration of Chemotherapeutic Agents

    PubMed Central

    Whipple, Nancy; Boulware, Joy; Danca, Kala; Boyarin, Kirill; Ginsberg, Eliot; Poon, Eric; Sweet, Micheal; Schade, Sue; Rogala, Jennifer

    2010-01-01

    The pharmacologic treatment for cancer must adhere to complex, finely orchestrated treatment plans, including not only chemotherapy medications, but pre/post-hydration, anti-emetics, anti-anxiety, and other medications that are given before, during and after chemotherapy doses. The treatment plans specify the medications and dictate precise dosing, frequency, and timing. This is a challenge to most Computerized Physician Order Entry (CPOE), Pharmacy and Electronic Medication Administration record (eMAR) Systems. Medications are scheduled on specific dates, referred to as chemo days, from the onset of the treatment, and precisely timed on the designated chemo day. For patients enrolled in research protocols, the adherence to the defined schedule takes on additional import, since variation is a violation of the protocol. If the oncologist determines that medications must be administered outside the defined constraints, the patient must be un-enrolled from the protocol and the course of therapy is re-written. Pharmacy and eMAR systems utilized in processing chemotherapy medications must be able to support the intricate relationships between each drug defined in the treatment plans. PMID:21347104

  17. Concurrent Schedules of Reinforcement as "Challenges" to Maintenance

    ERIC Educational Resources Information Center

    Peterson, Stephanie M.; Frieder, Jessica E.; Quigley, Shawn P.; Kestner, Kathryn M.; Goyal, Manish; Smith, Shilo L.; Dayton, Elizabeth; Brower-Breitwieser, Carrie

    2017-01-01

    One measure of success for interventions treating problem behavior is the effects achieved in the face of a challenge (e.g., changes in reinforcement schedules, lapses in treatment integrity); one hopes to demonstrate persistence of appropriate alternatives and the absence of resurgence of target behaviors. The present study successfully treated…

  18. Distributed network scheduling

    NASA Technical Reports Server (NTRS)

    Clement, Bradley J.; Schaffer, Steven R.

    2004-01-01

    Distributed Network Scheduling is the scheduling of future communications of a network by nodes in the network. This report details software for doing this onboard spacecraft in a remote network. While prior work on distributed scheduling has been applied to remote spacecraft networks, the software reported here focuses on modeling communication activities in greater detail and including quality of service constraints. Our main results are based on a Mars network of spacecraft and include identifying a maximum opportunity of improving traverse exploration rate a factor of three; a simulation showing reduction in one-way delivery times from a rover to Earth from as much as 5 to 1.5 hours; simulated response to unexpected events averaging under an hour onboard; and ground schedule generation ranging from seconds to 50 minutes for 15 to 100 communication goals.

  19. Surgical demand scheduling: a review.

    PubMed Central

    Magerlein, J M; Martin, J B

    1978-01-01

    This article reviews the literature on scheduling of patient demand for surgery and outlines an approach to improving overall performance of hospital surgical suites. Reported scheduling systems are categorized into those that schedule patients in advance of the surgical date and those that schedule available patients on the day of surgery. Approaches to estimating surgical procedure times are also reviewed, and the article concludes with a discussion of the failure to implement the majority of reported scheduling schemes. PMID:367987

  20. NASA Schedule Management Handbook

    NASA Technical Reports Server (NTRS)

    2011-01-01

    The purpose of schedule management is to provide the framework for time-phasing, resource planning, coordination, and communicating the necessary tasks within a work effort. The intent is to improve schedule management by providing recommended concepts, processes, and techniques used within the Agency and private industry. The intended function of this handbook is two-fold: first, to provide guidance for meeting the scheduling requirements contained in NPR 7120.5, NASA Space Flight Program and Project Management Requirements, NPR 7120.7, NASA Information Technology and Institutional Infrastructure Program and Project Requirements, NPR 7120.8, NASA Research and Technology Program and Project Management Requirements, and NPD 1000.5, Policy for NASA Acquisition. The second function is to describe the schedule management approach and the recommended best practices for carrying out this project control function. With regards to the above project management requirements documents, it should be noted that those space flight projects previously established and approved under the guidance of prior versions of NPR 7120.5 will continue to comply with those requirements until project completion has been achieved. This handbook will be updated as needed, to enhance efficient and effective schedule management across the Agency. It is acknowledged that most, if not all, external organizations participating in NASA programs/projects will have their own internal schedule management documents. Issues that arise from conflicting schedule guidance will be resolved on a case by case basis as contracts and partnering relationships are established. It is also acknowledged and understood that all projects are not the same and may require different levels of schedule visibility, scrutiny and control. Project type, value, and complexity are factors that typically dictate which schedule management practices should be employed.

  1. FlexMod Scheduling Redux

    ERIC Educational Resources Information Center

    Murray, Shannon

    2008-01-01

    Flexible modular scheduling (flex mod)--a schedule philosophy and system that has been in place at Wausau West High School in Wausau, Wisconsin, for the last 35 years and aligns nicely with current research on student learning--is getting more and more attention from high school administrators across the country. Flexible modular scheduling was…

  2. Characteristics of HIV patients who missed their scheduled appointments

    PubMed Central

    Nagata, Delsa; Gutierrez, Eliana Battaggia

    2016-01-01

    ABSTRACT OBJECTIVE To analyze whether sociodemographic characteristics, consultations and care in special services are associated with scheduled infectious diseases appointments missed by people living with HIV. METHODS This cross-sectional and analytical study included 3,075 people living with HIV who had at least one scheduled appointment with an infectologist at a specialized health unit in 2007. A secondary data base from the Hospital Management & Information System was used. The outcome variable was missing a scheduled medical appointment. The independent variables were sex, age, appointments in specialized and available disciplines, hospitalizations at the Central Institute of the Clinical Hospital at the Faculdade de Medicina of the Universidade de São Paulo, antiretroviral treatment and change of infectologist. Crude and multiple association analysis were performed among the variables, with a statistical significance of p ≤ 0.05. RESULTS More than a third (38.9%) of the patients missed at least one of their scheduled infectious diseases appointments; 70.0% of the patients were male. The rate of missed appointments was 13.9%, albeit with no observed association between sex and absences. Age was inversely associated to missed appointment. Not undertaking anti-retroviral treatment, having unscheduled infectious diseases consultations or social services care and being hospitalized at the Central Institute were directly associated to missed appointments. CONCLUSIONS The Hospital Management & Information System proved to be a useful tool for developing indicators related to the quality of health care of people living with HIV. Other informational systems, which are often developed for administrative purposes, can also be useful for local and regional management and for evaluating the quality of care provided for patients living with HIV. PMID:26786472

  3. 1993 Wholesale Power and Transmission Rate Schedules.

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    US Bonneville Power Administration

    1993-10-01

    Bonneville Power Administration 1993 Wholesale Power Rate Schedules and General Rate Schedule Provisions and 1993 Transmission Rate Schedules and General Transmission Rate Schedule Provisions, contained herein, were approved on an interim basis effective October 1, 1993. These rate schedules and provisions were approved by the Federal Energy Commission, United States Department of Energy, in September, 1993. These rate schedules and provisions supersede the Administration`s Wholesale Power Rate Schedules and General Rate Schedule Provisions and Transmission Rate Schedules and General Transmission Rate Schedule Provisions effective October 1, 1991.

  4. Investigations into Generalization of Constraint-Based Scheduling Theories with Applications to Space Telescope Observation Scheduling

    NASA Technical Reports Server (NTRS)

    Muscettola, Nicola; Smith, Steven S.

    1996-01-01

    This final report summarizes research performed under NASA contract NCC 2-531 toward generalization of constraint-based scheduling theories and techniques for application to space telescope observation scheduling problems. Our work into theories and techniques for solution of this class of problems has led to the development of the Heuristic Scheduling Testbed System (HSTS), a software system for integrated planning and scheduling. Within HSTS, planning and scheduling are treated as two complementary aspects of the more general process of constructing a feasible set of behaviors of a target system. We have validated the HSTS approach by applying it to the generation of observation schedules for the Hubble Space Telescope. This report summarizes the HSTS framework and its application to the Hubble Space Telescope domain. First, the HSTS software architecture is described, indicating (1) how the structure and dynamics of a system is modeled in HSTS, (2) how schedules are represented at multiple levels of abstraction, and (3) the problem solving machinery that is provided. Next, the specific scheduler developed within this software architecture for detailed management of Hubble Space Telescope operations is presented. Finally, experimental performance results are given that confirm the utility and practicality of the approach.

  5. Complex ambulatory settings demand scheduling systems.

    PubMed

    Ross, K M

    1998-01-01

    Practice management systems are becoming more and more complex, as they are asked to integrate all aspects of patient and resource management. Although patient scheduling is a standard expectation in any ambulatory environment, facilities and equipment resource scheduling are additional functionalities of scheduling systems. Because these functions were not typically managed in manual patient scheduling, often the result was resource mismanagement, along with a potential negative impact on utilization, patient flow and provider productivity. As ambulatory organizations have become more seasoned users of practice management software, the value of resource scheduling has become apparent. Appointment scheduling within a fully integrated practice management system is recognized as an enhancement of scheduling itself and provides additional tools to manage other information needs. Scheduling, as one component of patient information management, provides additional tools in these areas.

  6. Dispatch Scheduling of Automated Telescopes

    NASA Astrophysics Data System (ADS)

    Denny, R. B.

    2004-05-01

    Automated telescope scheduling systems have traditionally focused on optimiz- ing the use of the observatory, minimizing overhead and maximizing shutter- open time. However, educational and amateur observatories do not enjoy con- sistently good skies. Conditions can change significantly during an observing session, leading to schedule breakage. This gives rise to the need for a scheduling system that is capable of recovering from periods of bad skies, wind, etc. without operator intervention. The concept of dispatch scheduling, where the scheduler makes a "best" choice for the next observation, will be discussed. The choice of next target must consider constraints such as mini- mum altitude or maximum air mass, moon illumination, and sky condition, as well as timing constraints that may arise from linked observations and/or target phasing requirements. It also must be as fair and efficient as prac- tical. A dispatch scheduler (ACPS) was constructed and used to perform a num- ber of simulations with both isolated and multiple/linked observations, and noisy timing. By varying "best next target" choice algorithm, these simula- tions provided insight into the behavior of a dispatch scheduler. This talk will describe the scheduler and present the results of these preliminary sim- ulations, some conclusions that arose from them, and outline areas for fur- ther research.

  7. [Intrathecal methotrexate in breast cancer meningeal carcinomatosis - Experience with a new administration schedule].

    PubMed

    Cochereau, Delphine; Da Costa, Sabrina; Le Maignan, Christine; Gauthier, Hélène; Cochereau, Jérôme; Espié, Marc; Giacchetti, Sylvie; Teixeira, Luis

    2016-05-01

    Methotrexate represents the standard intrathecal treatment of breast cancer meningeal carcinomatosis. However, its optimal schedule remains undefined. The aim of the present study was to evaluate results obtained with the methotrexate schedule used in Saint-Louis hospital (Paris). Patients followed in Saint-Louis hospital for breast cancer and who received intrathecal methotrexate were included in this retrospective monocentric study. Intrathecal treatment received contained methotrexate 12 mg/day (days: 1-5) and then 15 mg/week until progression or toxicity. Between 2003 and 2015, 41 patients were included. Primitive tumours were RH+/HER2-, HER2+ and triple-negative in respectively 66%, 14%, 5% and 15% of patients, 22% of them had meningeal carcinomatosis as metastatic disease initial manifestation. Objective response rate was 54%, median overall survival was 4.0 mois [CI 95%: 3-7.3] and 1-year survival rate was 15.2% (11.4%, 50% et 0% in RH+/HER2-, HER2+ and triple-negative subgroups; HR=0.45 [0.21-0.97] between HER2+ and RH+/HER2-). In univariate analysis, prognostic factors were brain involvement (p=0.049), initial cerebrospinal fluid protein level (p=0.0002) and concomitant systemic treatment received (p=0.049). This intrathecal methotrexate schedule demonstrates a similar median overall survival as the one obtained with a dose-dense schedule and an improved quality of life. Nevertheless, as the objective response and 1-year survival rates are slightly inferior, a dose-dense schedule remains still preferred in HER2+ patients or in those harboring a mainly meningeal progression. Copyright © 2016 Société Française du Cancer. Published by Elsevier Masson SAS. All rights reserved.

  8. Treatment of aplastic anaemia with lower-dose anti-thymocyte globulin produces similar response rates and survival as per standard dose anti-thymocyte globulin schedules.

    PubMed

    Scott, A; Morris, K; Butler, J; Mills, A K; Kennedy, G A

    2016-10-01

    Aplastic anaemia (AA) is a rare acquired bone marrow failure syndrome resulting from the immune-mediated destruction of haemopoietic stem cells. For adults in whom first-line haemopoietic progenitor cell transplantation is not feasible, combination anti-thymocyte globulin (ATGAM) plus cyclosporine A is standard therapy; however, there are minimal data available regarding the optimal ATGAM dosage in terms of efficacy and survival. Our institutions have historically used different dosing protocols of ATGAM in the treatment of AA. We aimed to review the outcome of AA patients treated with these protocols and compare them to the published literature. We conducted a retrospective study of 31 adults who received first-line ATGAM for AA and compared response rates and survival between cohorts who received standard (40 mg/kg/day D1-4) versus lower-dose (15 mg/kg/day D1-5) ATGAM schedules. There were similar rates of response (64 vs 71%, P = 1.0), relapse (33 vs 33%, P = 1.0), transformation (14 vs 24%, P = 0.66) or infection (43 vs 47%, P = 1.0), respectively, between standard and lower-dose cohorts. At a median follow up of 24 months, there was no statistical difference between standard and lower-dose cohorts in either event-free (42.2 vs 64.7%, P = 0.91) or overall survival (73.1 vs 88.2%, P = 0.75). Our experience suggests that lower-dose ATGAM at 15 mg/kg/day D1-5 as treatment of AA produces similar responses and outcomes as per standard-dose ATGAM schedules. Prospective trials comparing ATGAM dose schedules in AA are warranted. © 2016 Royal Australasian College of Physicians.

  9. It Is Not Just about the Schedule: Key Factors in Effective Reference Desk Scheduling and Management

    ERIC Educational Resources Information Center

    Sciammarella, Susan; Fernandes, Maria Isabel; McKay, Devin

    2008-01-01

    Reference desk scheduling is one of the most challenging tasks in the organizational structure of an academic library. The ability to turn this challenge into a workable and effective function lies with the scheduler and indirectly the cooperation of all librarians scheduled for reference desk service. It is the scheduler's sensitivity to such…

  10. DTS: Building custom, intelligent schedulers

    NASA Technical Reports Server (NTRS)

    Hansson, Othar; Mayer, Andrew

    1994-01-01

    DTS is a decision-theoretic scheduler, built on top of a flexible toolkit -- this paper focuses on how the toolkit might be reused in future NASA mission schedulers. The toolkit includes a user-customizable scheduling interface, and a 'Just-For-You' optimization engine. The customizable interface is built on two metaphors: objects and dynamic graphs. Objects help to structure problem specifications and related data, while dynamic graphs simplify the specification of graphical schedule editors (such as Gantt charts). The interface can be used with any 'back-end' scheduler, through dynamically-loaded code, interprocess communication, or a shared database. The 'Just-For-You' optimization engine includes user-specific utility functions, automatically compiled heuristic evaluations, and a postprocessing facility for enforcing scheduling policies. The optimization engine is based on BPS, the Bayesian Problem-Solver (1,2), which introduced a similar approach to solving single-agent and adversarial graph search problems.

  11. 49 CFR Schedule C to Subpart B of... - Schedule C to Subpart B of Part 1139

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 8 2014-10-01 2014-10-01 false Schedule C to Subpart B of Part 1139 C Schedule C... REVENUE PROCEEDINGS Intercity Bus Industry Pt. 1139, Subpt. B, Sch. C Schedule C to Subpart B of Part 1139 Attachment 1 Schedule C Part I—Condensed Income Statement [Dollars in thousands] () Greyhound Lines, Inc...

  12. 49 CFR Schedule C to Subpart B of... - Schedule C to Subpart B of Part 1139

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 8 2011-10-01 2011-10-01 false Schedule C to Subpart B of Part 1139 C Schedule C... REVENUE PROCEEDINGS Intercity Bus Industry Pt. 1139, Subpt. B, Sch. C Schedule C to Subpart B of Part 1139 Attachment 1 Schedule C Part I—Condensed Income Statement [Dollars in thousands] () Greyhound Lines, Inc...

  13. 49 CFR Schedule C to Subpart B of... - Schedule C to Subpart B of Part 1139

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 8 2010-10-01 2010-10-01 false Schedule C to Subpart B of Part 1139 C Schedule C... REVENUE PROCEEDINGS Intercity Bus Industry Pt. 1139, Subpt. B, Sch. C Schedule C to Subpart B of Part 1139 Attachment 1 Schedule C Part I—Condensed Income Statement [Dollars in thousands] () Greyhound Lines, Inc...

  14. 46 CFR 525.2 - Terminal schedules.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... scrap, new assembled motor vehicles, waste paper and paper waste in terminal schedules. (2) Marine... MARITIME COMMISSION REGULATIONS AFFECTING OCEAN SHIPPING IN FOREIGN COMMERCE MARINE TERMINAL OPERATOR SCHEDULES § 525.2 Terminal schedules. (a) Marine terminal operator schedules. A marine terminal operator, at...

  15. 46 CFR 525.2 - Terminal schedules.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... scrap, new assembled motor vehicles, waste paper and paper waste in terminal schedules. (2) Marine... MARITIME COMMISSION REGULATIONS AFFECTING OCEAN SHIPPING IN FOREIGN COMMERCE MARINE TERMINAL OPERATOR SCHEDULES § 525.2 Terminal schedules. (a) Marine terminal operator schedules. A marine terminal operator, at...

  16. 29 CFR 825.203 - Scheduling of intermittent or reduced schedule leave.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... OF LABOR OTHER LAWS THE FAMILY AND MEDICAL LEAVE ACT OF 1993 Employee Leave Entitlements Under the Family and Medical Leave Act § 825.203 Scheduling of intermittent or reduced schedule leave. Eligible... the serious health condition of a covered family member or the employee or the serious injury or...

  17. Scheduling: A guide for program managers

    NASA Technical Reports Server (NTRS)

    1994-01-01

    The following topics are discussed concerning scheduling: (1) milestone scheduling; (2) network scheduling; (3) program evaluation and review technique; (4) critical path method; (5) developing a network; (6) converting an ugly duckling to a swan; (7) network scheduling problem; (8) (9) network scheduling when resources are limited; (10) multi-program considerations; (11) influence on program performance; (12) line-of-balance technique; (13) time management; (14) recapitulization; and (15) analysis.

  18. Reactive Scheduling in Multipurpose Batch Plants

    NASA Astrophysics Data System (ADS)

    Narayani, A.; Shaik, Munawar A.

    2010-10-01

    Scheduling is an important operation in process industries for improving resource utilization resulting in direct economic benefits. It has a two-fold objective of fulfilling customer orders within the specified time as well as maximizing the plant profit. Unexpected disturbances such as machine breakdown, arrival of rush orders and cancellation of orders affect the schedule of the plant. Reactive scheduling is generation of a new schedule which has minimum deviation from the original schedule in spite of the occurrence of unexpected events in the plant operation. Recently, Shaik & Floudas (2009) proposed a novel unified model for short-term scheduling of multipurpose batch plants using unit-specific event-based continuous time representation. In this paper, we extend the model of Shaik & Floudas (2009) to handle reactive scheduling.

  19. Schedule-Aware Workflow Management Systems

    NASA Astrophysics Data System (ADS)

    Mans, Ronny S.; Russell, Nick C.; van der Aalst, Wil M. P.; Moleman, Arnold J.; Bakker, Piet J. M.

    Contemporary workflow management systems offer work-items to users through specific work-lists. Users select the work-items they will perform without having a specific schedule in mind. However, in many environments work needs to be scheduled and performed at particular times. For example, in hospitals many work-items are linked to appointments, e.g., a doctor cannot perform surgery without reserving an operating theater and making sure that the patient is present. One of the problems when applying workflow technology in such domains is the lack of calendar-based scheduling support. In this paper, we present an approach that supports the seamless integration of unscheduled (flow) and scheduled (schedule) tasks. Using CPN Tools we have developed a specification and simulation model for schedule-aware workflow management systems. Based on this a system has been realized that uses YAWL, Microsoft Exchange Server 2007, Outlook, and a dedicated scheduling service. The approach is illustrated using a real-life case study at the AMC hospital in the Netherlands. In addition, we elaborate on the experiences obtained when developing and implementing a system of this scale using formal techniques.

  20. Neurological Adverse Effects in Patients of Advanced Colorectal Carcinoma Treated with Different Schedules of FOLFOX

    PubMed Central

    Najam, Rahila; Mateen, Ahmed

    2013-01-01

    The study is designed to assess the frequency and severity of few dose limiting neurological adverse effects of four different schedules of FOLFOX. Patients with histologically confirmed advanced colorectal carcinoma (CRC) were included in the study. Toxicity was graded according to CTC v 2.0. The frequency of grade 3 and 4 adverse effects was comparatively assessed in each treatment arm. The difference in the pattern of toxicity between the treatment schedule was evaluated. The most frequent adverse symptom of neurological adverse effect was grade 1 paresthesia in the patients treated with FOLFOX4 schedule. Grade 4 peripheral neuropathy was reported in few patients of FOLFOX7 treatment arm. Frequency and onset of neurological adverse effects like paresthesia, dizziness, and hypoesthesia were significantly different (P < 0.05), whereas frequency and onset of peripheral neuropathy were highly significant (P < 0.01) in each treatment arm of FOLFOX. Peripheral neuropathy was associated with electrolyte imbalance and diabetes in few patients. Frequency of symptoms, for example, paresthesia, is associated with increased number of recurrent exposure to oxaliplatin (increased number of cycles) even at low doses (85 mg/m2), whereas severity of symptoms, for example, peripheral neuropathy, is associated with higher dose (130 mg/m2) after few treatment cycles. PMID:24187619

  1. SPANR planning and scheduling

    NASA Astrophysics Data System (ADS)

    Freund, Richard F.; Braun, Tracy D.; Kussow, Matthew; Godfrey, Michael; Koyama, Terry

    2001-07-01

    SPANR (Schedule, Plan, Assess Networked Resources) is (i) a pre-run, off-line planning and (ii) a runtime, just-in-time scheduling mechanism. It is designed to support primarily commercial applications in that it optimizes throughput rather than individual jobs (unless they have highest priority). Thus it is a tool for a commercial production manager to maximize total work. First the SPANR Planner is presented showing the ability to do predictive 'what-if' planning. It can answer such questions as, (i) what is the overall effect of acquiring new hardware or (ii) what would be the effect of a different scheduler. The ability of the SPANR Planner to formulate in advance tree-trimming strategies is useful in several commercial applications, such as electronic design or pharmaceutical simulations. The SPANR Planner is demonstrated using a variety of benchmarks. The SPANR Runtime Scheduler (RS) is briefly presented. The SPANR RS can provide benefit for several commercial applications, such as airframe design and financial applications. Finally a design is shown whereby SPANR can provide scheduling advice to most resource management systems.

  2. Self-scheduling with Microsoft Excel.

    PubMed

    Irvin, S A; Brown, H N

    1999-01-01

    Excessive time was being spent by the emergency department (ED) staff, head nurse, and unit secretary on a complex 6-week manual self-scheduling system. This issue, plus inevitable errors and staff dissatisfaction, resulted in a manager-lead initiative to automate elements of the scheduling process using Microsoft Excel. The implementation of this initiative included: common coding of all 8-hour and 12-hour shifts, with each 4-hour period represented by a cell; the creation of a 6-week master schedule using the "count-if" function of Excel based on current staffing guidelines; staff time-off requests then entered by the department secretary; the head nurse, with staff input, then fine-tuned the schedule to provide even unit coverage. Outcomes of these changes included an increase in staff satisfaction, time saved by the head nurse, and staff work time saved because there was less arguing about the schedule. Ultimately, the automated self-scheduling method was expanded to the entire 700-bed hospital.

  3. The LSST OCS scheduler design

    NASA Astrophysics Data System (ADS)

    Delgado, Francisco; Schumacher, German

    2014-08-01

    The Large Synoptic Survey Telescope (LSST) is a complex system of systems with demanding performance and operational requirements. The nature of its scientific goals requires a special Observatory Control System (OCS) and particularly a very specialized automatic Scheduler. The OCS Scheduler is an autonomous software component that drives the survey, selecting the detailed sequence of visits in real time, taking into account multiple science programs, the current external and internal conditions, and the history of observations. We have developed a SysML model for the OCS Scheduler that fits coherently in the OCS and LSST integrated model. We have also developed a prototype of the Scheduler that implements the scheduling algorithms in the simulation environment provided by the Operations Simulator, where the environment and the observatory are modeled with real weather data and detailed kinematics parameters. This paper expands on the Scheduler architecture and the proposed algorithms to achieve the survey goals.

  4. Mission and science activity scheduling language

    NASA Technical Reports Server (NTRS)

    Hull, Larry G.

    1993-01-01

    To support the distributed and complex operational scheduling required for future National Aeronautics and Space Administration (NASA) missions, a formal, textual language, the Scheduling Applications Interface Language (SAIL), has been developed. Increased geographic dispersion of investigators is leading to distributed mission and science activity planning, scheduling, and operations. SAIL is an innovation which supports the effective and efficient communication of scheduling information among physically dispersed applications in distributed scheduling environments. SAIL offers a clear, concise, unambiguous expression of scheduling information in a readable, hardware independent format. The language concept, syntax, and semantics incorporate language features found useful during five years of research and prototyping with scheduling languages in physically distributed environments. SAIL allows concise specification of mission and science activity plans in a format which promotes repetition and reuse.

  5. Block Scheduling in High Schools.

    ERIC Educational Resources Information Center

    Irmsher, Karen

    1996-01-01

    Block Scheduling has been considered a cure for a lengthy list of educational problems. This report reviews the literature on block schedules and describes some Oregon high schools that have integrated block scheduling. Major disadvantages included resistance to change and requirements that teachers change their teaching strategies. There is…

  6. COMPASS: An Ada based scheduler

    NASA Technical Reports Server (NTRS)

    Mcmahon, Mary Beth; Culbert, Chris

    1992-01-01

    COMPASS is a generic scheduling system developed by McDonnell Douglas and funded by the Software Technology Branch of NASA Johnson Space Center. The motivation behind COMPASS is to illustrate scheduling technology and provide a basis from which custom scheduling systems can be built. COMPASS was written in Ada to promote readability and to conform to DOD standards. COMPASS has some unique characteristics that distinguishes it from commercial products. This paper discusses these characteristics and uses them to illustrate some differences between scheduling tools.

  7. Pre-Scheduled and Self Organized Sleep-Scheduling Algorithms for Efficient K-Coverage in Wireless Sensor Networks

    PubMed Central

    Hwang, I-Shyan

    2017-01-01

    The K-coverage configuration that guarantees coverage of each location by at least K sensors is highly popular and is extensively used to monitor diversified applications in wireless sensor networks. Long network lifetime and high detection quality are the essentials of such K-covered sleep-scheduling algorithms. However, the existing sleep-scheduling algorithms either cause high cost or cannot preserve the detection quality effectively. In this paper, the Pre-Scheduling-based K-coverage Group Scheduling (PSKGS) and Self-Organized K-coverage Scheduling (SKS) algorithms are proposed to settle the problems in the existing sleep-scheduling algorithms. Simulation results show that our pre-scheduled-based KGS approach enhances the detection quality and network lifetime, whereas the self-organized-based SKS algorithm minimizes the computation and communication cost of the nodes and thereby is energy efficient. Besides, SKS outperforms PSKGS in terms of network lifetime and detection quality as it is self-organized. PMID:29257078

  8. Instant Childhood Immunization Schedule

    MedlinePlus

    ... Recommendations Why Immunize? Vaccines: The Basics Instant Childhood Immunization Schedule Recommend on Facebook Tweet Share Compartir Get ... date. See Disclaimer for additional details. Based on Immunization Schedule for Children 0 through 6 Years of ...

  9. Online Appointment Scheduling for a Nuclear Medicine Department in a Chinese Hospital

    PubMed Central

    Feng, Ya-bing

    2018-01-01

    Nuclear medicine, a subspecialty of radiology, plays an important role in proper diagnosis and timely treatment. Multiple resources, especially short-lived radiopharmaceuticals involved in the process of nuclear medical examination, constitute a unique problem in appointment scheduling. Aiming at achieving scientific and reasonable appointment scheduling in the West China Hospital (WCH), a typical class A tertiary hospital in China, we developed an online appointment scheduling algorithm based on an offline nonlinear integer programming model which considers multiresources allocation, the time window constraints imposed by short-lived radiopharmaceuticals, and the stochastic nature of the patient requests when scheduling patients. A series of experiments are conducted to show the effectiveness of the proposed strategy based on data provided by the WCH. The results show that the examination amount increases by 29.76% compared with the current one with a significant increase in the resource utilization and timely rate. Besides, it also has a high stability for stochastic factors and bears the advantage of convenient and economic operation. PMID:29849748

  10. Nontraditional work schedules for pharmacists.

    PubMed

    Mahaney, Lynnae; Sanborn, Michael; Alexander, Emily

    2008-11-15

    Nontraditional work schedules for pharmacists at three institutions are described. The demand for pharmacists and health care in general continues to increase, yet significant material changes are occurring in the pharmacy work force. These changing demographics, coupled with historical vacancy rates and turnover trends for pharmacy staff, require an increased emphasis on workplace changes that can improve staff recruitment and retention. At William S. Middleton Memorial Veterans Affairs Hospital in Madison, Wisconsin, creative pharmacist work schedules and roles are now mainstays to the recruitment and retention of staff. The major challenge that such scheduling presents is the 8 hours needed to prepare a six-week schedule. Baylor Medical Center at Grapevine in Dallas, Texas, has a total of 45 pharmacy employees, and slightly less than half of the 24.5 full-time-equivalent staff work full-time, with most preferring to work one, two, or three days per week. As long as the coverage needs of the facility are met, Envision Telepharmacy in Alpine, Texas, allows almost any scheduling arrangement preferred by individual pharmacists or the pharmacist group covering the facility. Staffing involves a great variety of shift lengths and intervals, with shifts ranging from 2 to 10 hours. Pharmacy leaders must be increasingly aware of opportunities to provide staff with unique scheduling and operational enhancements that can provide for a better work-life balance. Compressed workweeks, job-sharing, and team scheduling were the most common types of alternative work schedules implemented at three different institutions.

  11. The Development of Patient Scheduling Groups for an Effective Appointment System

    PubMed Central

    2016-01-01

    Summary Background Patient access to care and long wait times has been identified as major problems in outpatient delivery systems. These aspects impact medical staff productivity, service quality, clinic efficiency, and health-care cost. Objectives This study proposed to redesign existing patient types into scheduling groups so that the total cost of clinic flow and scheduling flexibility was minimized. The optimal scheduling group aimed to improve clinic efficiency and accessibility. Methods The proposed approach used the simulation optimization technique and was demonstrated in a Primary Care physician clinic. Patient type included, emergency/urgent care (ER/UC), follow-up (FU), new patient (NP), office visit (OV), physical exam (PE), and well child care (WCC). One scheduling group was designed for this physician. The approach steps were to collect physician treatment time data for each patient type, form the possible scheduling groups, simulate daily clinic flow and patient appointment requests, calculate costs of clinic flow as well as appointment flexibility, and find the scheduling group that minimized the total cost. Results The cost of clinic flow was minimized at the scheduling group of four, an 8.3% reduction from the group of one. The four groups were: 1. WCC, 2. OV, 3. FU and ER/UC, and 4. PE and NP. The cost of flexibility was always minimized at the group of one. The total cost was minimized at the group of two. WCC was considered separate and the others were grouped together. The total cost reduction was 1.3% from the group of one. Conclusions This study provided an alternative method of redesigning patient scheduling groups to address the impact on both clinic flow and appointment accessibility. Balance between them ensured the feasibility to the recognized issues of patient service and access to care. The robustness of the proposed method on the changes of clinic conditions was also discussed. PMID:27081406

  12. High on-clopidogrel treatment platelet reactivity in Thai patients with chronic stable angina scheduled for percutaneous coronary intervention.

    PubMed

    Phankingthongkum, Rewat; Panchavinnin, Pradit; Chinthammitr, Yingyong; Tresukosol, Damras; Chotinaiwattarakul, Chunhakasem; Tungsubutra, Wiwun; Wongpraparut, Nattawut; Kitrattana, Bussakorn; Leewanun, Piyachat

    2013-05-01

    To determine the prevalence, clinical profile, and risk factors of high on-clopidogrel treatment platelet reactivity in Thai patients with chronic stable angina scheduled for percutaneous coronary intervention. The patients were prospectively recruited from the consecutive patients undergoing coronary angiography and planned for elective percutaneous coronary intervention (PCI). Ten ml of blood samples were cautiously drawn from the antecubital vein of the patients to determine the hemoglobin and platelet count. Platelet aggregation test was performed by light transmittance aggregometry using platelet-rich plasma. Platelets were stimulated with 5 microM adenosine diphosphate (ADP). Platelet aggregation was expressed as the maximal percent change in light transmittance from baseline. High on-clopidogrel treatment platelet reactivity was defined as post treatment maximal platelet aggregation > 46% with 5 micromol/l ADP used as agonist. The present study consecutively enrolled two hundred four patients diagnosed with chronic stable angina planned for PCI. Seventy-nine patients demonstrated the high on-clopidogrel treatment platelet reactivity (38.7%). Among these patients, 48% were men with a mean age of 66 years. Diabetes mellitus and chronic kidney disease were detected in 34.2%. Original clopidogrel (Plavix) was prescribed in 72% of the patients and 28% received generic clopidogrel (Apolets). The prevalence of high on-clopidogrel treatment platelet reactivity increased in the older patients, patients with CKD and patients receiving angiotensin receptor blockers (ARB). However from multivariate analysis, none of the risk factors, including age, BMl, diabetes mellitus, smoking, CKD, ARB use, and type of clopidogrel (Plavix versus Apolets) had a statistically significant association with the high on-clopidogrel treatment platelet reactivity. The prevalence of high on-clopidogrel treatment platelet reactivity in the present study was 38.7%. No significant association

  13. Flexible Scheduling to Fit the Firefighters.

    ERIC Educational Resources Information Center

    Cox, Clarice Robinson

    Three flexible scheduling plans were tried in order that firefighters could take regular college courses despite their 24 hours on the 24 off work schedule. Plan one scheduled the firefighters into a regular Monday-Wednesday-Friday class which they attended every other week, making up missed material outside of class. Plan two scheduled special…

  14. Astronaut Office Scheduling System Software

    NASA Technical Reports Server (NTRS)

    Brown, Estevancio

    2010-01-01

    AOSS is a highly efficient scheduling application that uses various tools to schedule astronauts weekly appointment information. This program represents an integration of many technologies into a single application to facilitate schedule sharing and management. It is a Windows-based application developed in Visual Basic. Because the NASA standard office automation load environment is Microsoft-based, Visual Basic provides AO SS developers with the ability to interact with Windows collaboration components by accessing objects models from applications like Outlook and Excel. This also gives developers the ability to create newly customizable components that perform specialized tasks pertaining to scheduling reporting inside the application. With this capability, AOSS can perform various asynchronous tasks, such as gathering/ sending/ managing astronauts schedule information directly to their Outlook calendars at any time.

  15. Scheduling cisplatin and radiotherapy in the treatment of squamous cell carcinomas of the head and neck: a modelling approach

    NASA Astrophysics Data System (ADS)

    Marcu, L.; Bezak, E.; Olver, I.

    2006-08-01

    The aim of the present work was to implement the kinetics of cisplatin into a previously developed tumour growth model and to simulate the combined cisplatin-radiotherapy treatment with the emphasis on time sequencing and scheduling of drug and radiation. An investigation into whether the effect of cisplatin-radiation is determined by independent cell kill or by cisplatin-produced radiosensitization was also undertaken. It was shown that cisplatin administered before radiation conferred similar tumour control to the post-radiation sequencing of the drug. The killing effect of the combined modality treatment on tumour increased with the increase in cell recruitment. Furthermore, the individual cell kill produced by the two cytotoxins led to an additive only tumour response when the treatments were given concurrently, suggesting that for a synergistic effect, cisplatin must potentiate the effect of radiation, through the radiosensitizing mechanisms addressed in the literature. It was concluded that the optimal timing of cisplatin should be close to radiation. The model showed that daily administration of cisplatin led to a 35% improvement of tumour control as compared to radiation alone, while weekly cisplatin has improved radiotherapy by only 6%.

  16. The Use of Descriptive Analysis to Identify and Manipulate Schedules of Reinforcement in the Treatment of Food Refusal

    ERIC Educational Resources Information Center

    Casey, Sean D.; Cooper-Brown, Linda J.; Wacker, David P.; Rankin, Barbara E.

    2006-01-01

    The feeding behaviors of a child diagnosed with failure to thrive were assessed using descriptive analysis methodology to identify the schedules of reinforcement provided by the child's parents. This analysis revealed that the child's appropriate feeding behaviors (i.e., bite acceptance, self-feeding) were on a lean schedule of positive…

  17. Surprise Benefits of Arena Scheduling

    ERIC Educational Resources Information Center

    Surloff, Andrew

    2008-01-01

    One of the most challenging tasks a principal must accomplish every year is the construction of the master schedule. Free from the magnetic scheduling boards and wall charts of yesteryear, principals now have technological tools--such as programs that offer schools solutions for their scheduling needs--that can save time and enable them to work…

  18. State Alternative Work Schedule Manual.

    ERIC Educational Resources Information Center

    Long, Marion C.; Post, Susan W.

    During recent years, there has been increasing interest within both the public and private sectors in the use of alternative work schedules. While a sizable body of literature exists on the use of work scheduling variations among private employers, there is a dearth of information concerning the extent and impact of alternative work schedules in…

  19. A Practical Variation of a Multiple-Schedule Procedure: Brief Schedule-Correlated Stimuli

    ERIC Educational Resources Information Center

    Tiger, Jeffrey H.; Hanley, Gregory P.; Larsen, Kylie M.

    2008-01-01

    Multiple schedules using continuous discriminative stimuli have been used to minimize children's disruptive requesting for teacher attention (e.g., colored floral leis; Tiger & Hanley, 2004; Tiger, Hanley, & Heal, 2006). The present study evaluated the effectiveness of, and children's preferences for, two multiple-schedule arrangements in which…

  20. Light treatment for NASA shiftworkers.

    PubMed

    Stewart, K T; Hayes, B C; Eastman, C I

    1995-04-01

    Intense artificial light can phase-shift circadian rhythms and improve performance, sleep, and well-being during shiftwork simulations. In real shiftworkers, however, exposure to sunlight and other time cues may decrease the efficacy of light treatment, and occupational and family responsibilities may make it impractical. With these considerations in mind, we designed and tested light-treatment protocols for NASA personnel who worked on shifted schedules during two Space Shuttle missions. During the prelaunch week, treatment subjects self-administered light of approximately 10,000 lux at times of day that phase-delay circadian rhythms. Treatment continued during the missions and for several days afterward. No treatment was administered to subjects in the control group. Treatment subjects reported better sleep, performance, and physical and emotional well-being than control subjects and rated the treatment as highly effective for promoting adjustment to their work schedules. Light treatment is both feasible and beneficial for NASA personnel who must work on shifted schedules during Space Shuttle missions.

  1. How do current irrigation practices perform? Evaluation of different irrigation scheduling approaches based on experiements and crop model simulations

    NASA Astrophysics Data System (ADS)

    Seidel, Sabine J.; Werisch, Stefan; Barfus, Klemens; Wagner, Michael; Schütze, Niels; Laber, Hermann

    2014-05-01

    coefficients, and (ii) one treatment was automatically drip irrigated using tensiometers (irrigation of 15 mm at a soil tension of -250 hPa at 30 cm soil depth). In treatment (iii), the irrigation schedule was estimated (using the same critera as in the tension-based treatment) applying the model Daisy partially calibrated against data of 2012. Moreover, one control treatment was minimally irrigated. Measured yield was highest for the tension-based treatment with a low irrigation water input (8.5 DM t/ha, 120 mm). Both SWB treatments showed lower yields and higher irrigation water input (both 8.3 DM t/ha, 306 and 410 mm). The simulation model based treatment yielded lower (7.5 DM t/ha, 106 mm) mainly due to drought stress caused by inaccurate simulation of the soil water dynamics and thus an overestimation of the soil moisture. The evaluation using the calibrated model estimated heavy deep percolation under both SWB treatments. Targeting the challenge to increase water productivity, soil water tension-based irrigation should be favoured. Irrigation scheduling based on SWB calculation requires accurate estimates of crop coefficients. A robust calibration of mechanistic crop models implies a high effort and can be recommended to farmers only to some extent but enables comprehensive crop growth and site analyses.

  2. Distributed intelligent scheduling of FMS

    NASA Astrophysics Data System (ADS)

    Wu, Zuobao; Cheng, Yaodong; Pan, Xiaohong

    1995-08-01

    In this paper, a distributed scheduling approach of a flexible manufacturing system (FMS) is presented. A new class of Petri nets called networked time Petri nets (NTPN) for system modeling of networking environment is proposed. The distributed intelligent scheduling is implemented by three schedulers which combine NTPN models with expert system techniques. The simulation results are shown.

  3. A planning language for activity scheduling

    NASA Technical Reports Server (NTRS)

    Zoch, David R.; Lavallee, David; Weinstein, Stuart; Tong, G. Michael

    1991-01-01

    Mission planning and scheduling of spacecraft operations are becoming more complex at NASA. Described here are a mission planning process; a robust, flexible planning language for spacecraft and payload operations; and a software scheduling system that generates schedules based on planning language inputs. The mission planning process often involves many people and organizations. Consequently, a planning language is needed to facilitate communication, to provide a standard interface, and to represent flexible requirements. The software scheduling system interprets the planning language and uses the resource, time duration, constraint, and alternative plan flexibilities to resolve scheduling conflicts.

  4. Optimization of direct anti-viral agent treatment schedule: Focus on HCV genotype 3.

    PubMed

    Morisco, Filomena; Granata, Rocco; Camera, Silvia; Ippolito, Antonio; Milella, Michele; Conti, Fabio; Masetti, Chiara; Smedile, Antonella; Tundo, Paolo; Santantonio, Teresa; Valvano, Maria Rosa; Termite, Antonio; Gatti, Pietro; Messina, Vincenzo; Iacobellis, Angelo; Librandi, Marta; Caporaso, Nicola; Andriulli, Angelo

    2018-03-01

    Direct antiviral agents (DAAs) have led to high sustained virological responses (SVR) in hepatitis C virus (HCV) patients. However, genotype 3 patients respond to treatment in a suboptimal way. This study aims to identify which of the several treatment schedules recommended for genotype 3 would constitute the best option. Twenty-four Italian centers were involved in this real-life study of HCV genotype 3 patients treated with DAAs. To expand the number of cases, we conducted a systematic review of the literature on the outcome of genotype 3 patients treated with DAAs. A total of 233 patients with HCV genotype 3 were enrolled. Cirrhotic patients accounted for 83.7%. Overall, the SVR12 rate was achieved by 205 patients (88.0%); the SVR rates were 78.8% after sofosbuvir/ribavirin, 92.5% after sofosbuvir/daclatasvir ± ribavirin, and 100% after sofosbuvir/ledipasvir (seven patients). No difference in rate of SVR was observed in cirrhotic and non-cirrhotic patients (92.2 vs 94.4) using a combination regimen of NS5A and NS5B inhibitors.The systematic review of the literature provided data of 3311 patients: The mean weighted SVR12 rate was 84.4% (CI: 80.4-87.8); the rates varied from 79.0% (CI: 70.9-85.3) with sofosbuvir/ribavirin, to 83.7% (CI: 66.2-93.1) with sofosbuvir/ledispavir, and to 88.2% (CI: 83.3-91.7) with sofosbuvir/daclatasvir. Our results reinforce the concept that patients with HCV genotype 3 should no longer be considered difficult-to-treat individuals. The optimal therapeutic regimen for these patients appears to be the combination sofosbuvir/daclatasvir, administered for 12 weeks without the use of RBV in non-cirrhotic patients. In cirrhotics the meta-analytic approach suggests extending therapy to 24 weeks.

  5. Real-time scheduling using minimum search

    NASA Technical Reports Server (NTRS)

    Tadepalli, Prasad; Joshi, Varad

    1992-01-01

    In this paper we consider a simple model of real-time scheduling. We present a real-time scheduling system called RTS which is based on Korf's Minimin algorithm. Experimental results show that the schedule quality initially improves with the amount of look-ahead search and tapers off quickly. So it sppears that reasonably good schedules can be produced with a relatively shallow search.

  6. Stochastic online appointment scheduling of multi-step sequential procedures in nuclear medicine.

    PubMed

    Pérez, Eduardo; Ntaimo, Lewis; Malavé, César O; Bailey, Carla; McCormack, Peter

    2013-12-01

    The increased demand for medical diagnosis procedures has been recognized as one of the contributors to the rise of health care costs in the U.S. in the last few years. Nuclear medicine is a subspecialty of radiology that uses advanced technology and radiopharmaceuticals for the diagnosis and treatment of medical conditions. Procedures in nuclear medicine require the use of radiopharmaceuticals, are multi-step, and have to be performed under strict time window constraints. These characteristics make the scheduling of patients and resources in nuclear medicine challenging. In this work, we derive a stochastic online scheduling algorithm for patient and resource scheduling in nuclear medicine departments which take into account the time constraints imposed by the decay of the radiopharmaceuticals and the stochastic nature of the system when scheduling patients. We report on a computational study of the new methodology applied to a real clinic. We use both patient and clinic performance measures in our study. The results show that the new method schedules about 600 more patients per year on average than a scheduling policy that was used in practice by improving the way limited resources are managed at the clinic. The new methodology finds the best start time and resources to be used for each appointment. Furthermore, the new method decreases patient waiting time for an appointment by about two days on average.

  7. Future aircraft networks and schedules

    NASA Astrophysics Data System (ADS)

    Shu, Yan

    2011-07-01

    Because of the importance of air transportation scheduling, the emergence of small aircraft and the vision of future fuel-efficient aircraft, this thesis has focused on the study of aircraft scheduling and network design involving multiple types of aircraft and flight services. It develops models and solution algorithms for the schedule design problem and analyzes the computational results. First, based on the current development of small aircraft and on-demand flight services, this thesis expands a business model for integrating on-demand flight services with the traditional scheduled flight services. This thesis proposes a three-step approach to the design of aircraft schedules and networks from scratch under the model. In the first step, both a frequency assignment model for scheduled flights that incorporates a passenger path choice model and a frequency assignment model for on-demand flights that incorporates a passenger mode choice model are created. In the second step, a rough fleet assignment model that determines a set of flight legs, each of which is assigned an aircraft type and a rough departure time is constructed. In the third step, a timetable model that determines an exact departure time for each flight leg is developed. Based on the models proposed in the three steps, this thesis creates schedule design instances that involve almost all the major airports and markets in the United States. The instances of the frequency assignment model created in this thesis are large-scale non-convex mixed-integer programming problems, and this dissertation develops an overall network structure and proposes iterative algorithms for solving these instances. The instances of both the rough fleet assignment model and the timetable model created in this thesis are large-scale mixed-integer programming problems, and this dissertation develops subproblem schemes for solving these instances. Based on these solution algorithms, this dissertation also presents

  8. Conception of Self-Construction Production Scheduling System

    NASA Astrophysics Data System (ADS)

    Xue, Hai; Zhang, Xuerui; Shimizu, Yasuhiro; Fujimura, Shigeru

    With the high speed innovation of information technology, many production scheduling systems have been developed. However, a lot of customization according to individual production environment is required, and then a large investment for development and maintenance is indispensable. Therefore now the direction to construct scheduling systems should be changed. The final objective of this research aims at developing a system which is built by it extracting the scheduling technique automatically through the daily production scheduling work, so that an investment will be reduced. This extraction mechanism should be applied for various production processes for the interoperability. Using the master information extracted by the system, production scheduling operators can be supported to accelerate the production scheduling work easily and accurately without any restriction of scheduling operations. By installing this extraction mechanism, it is easy to introduce scheduling system without a lot of expense for customization. In this paper, at first a model for expressing a scheduling problem is proposed. Then the guideline to extract the scheduling information and use the extracted information is shown and some applied functions are also proposed based on it.

  9. Range Scheduling Aid (RSA)

    NASA Technical Reports Server (NTRS)

    Logan, J. R.; Pulvermacher, M. K.

    1991-01-01

    Range Scheduling Aid (RSA) is presented in the form of the viewgraphs. The following subject areas are covered: satellite control network; current and new approaches to range scheduling; MITRE tasking; RSA features; RSA display; constraint based analytic capability; RSA architecture; and RSA benefits.

  10. Dosing Schedules for Pneumococcal Conjugate Vaccine

    PubMed Central

    2014-01-01

    Since second generation pneumococcal conjugate vaccines (PCVs) targeting 10 and 13 serotypes became available in 2010, the number of national policy makers considering these vaccines has steadily increased. An important consideration for a national immunization program is the timing and number of doses—the schedule—that will best prevent disease in the population. Data on disease epidemiology and the efficacy or effectiveness of PCV schedules are typically considered when choosing a schedule. Practical concerns, such as the existing vaccine schedule, and vaccine program performance are also important. In low-income countries, pneumococcal disease and deaths typically peak well before the end of the first year of life, making a schedule that provides PCV doses early in life (eg, a 6-, 10- and 14-week schedule) potentially the best option. In other settings, a schedule including a booster dose may address disease that peaks in the second year of life or may be seen to enhance a schedule already in place. A large and growing body of evidence from immunogenicity studies, as well as clinical trials and observational studies of carriage, pneumonia and invasive disease, has been systematically reviewed; these data indicate that schedules of 3 or 4 doses all work well, and that the differences between these regimens are subtle, especially in a mature program in which coverage is high and indirect (herd) effects help enhance protection provided directly by a vaccine schedule. The recent World Health Organization policy statement on PCVs endorsed a schedule of 3 primary doses without a booster or, as a new alternative, 2 primary doses with a booster dose. While 1 schedule may be preferred in a particular setting based on local epidemiology or practical considerations, achieving high coverage with 3 doses is likely more important than the specific timing of doses. PMID:24336059

  11. Testing Task Schedulers on Linux System

    NASA Astrophysics Data System (ADS)

    Jelenković, Leonardo; Groš, Stjepan; Jakobović, Domagoj

    Testing task schedulers on Linux operating system proves to be a challenging task. There are two main problems. The first one is to identify which properties of the scheduler to test. The second problem is how to perform it, e.g., which API to use that is sufficiently precise and in the same time supported on most platforms. This paper discusses the problems in realizing test framework for testing task schedulers and presents one potential solution. Observed behavior of the scheduler is the one used for “normal” task scheduling (SCHED_OTHER), unlike one used for real-time tasks (SCHED_FIFO, SCHED_RR).

  12. Scheduler Design Criteria: Requirements and Considerations

    NASA Technical Reports Server (NTRS)

    Lee, Hanbong

    2016-01-01

    This presentation covers fundamental requirements and considerations for developing schedulers in airport operations. We first introduce performance and functional requirements for airport surface schedulers. Among various optimization problems in airport operations, we focus on airport surface scheduling problem, including runway and taxiway operations. We then describe a basic methodology for airport surface scheduling such as node-link network model and scheduling algorithms previously developed. Next, we explain how to design a mathematical formulation in more details, which consists of objectives, decision variables, and constraints. Lastly, we review other considerations, including optimization tools, computational performance, and performance metrics for evaluation.

  13. 77 FR 63766 - Schedules of Controlled Substances: Placement of Methylone Into Schedule I

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-17

    ... DEPARTMENT OF JUSTICE Drug Enforcement Administration 21 CFR Part 1308 [Docket No. DEA-357] Schedules of Controlled Substances: Placement of Methylone Into Schedule I AGENCY: Drug Enforcement Administration, Department of Justice. ACTION: Notice of proposed rulemaking. SUMMARY: The Drug Enforcement...

  14. Scheduling with genetic algorithms

    NASA Technical Reports Server (NTRS)

    Fennel, Theron R.; Underbrink, A. J., Jr.; Williams, George P. W., Jr.

    1994-01-01

    In many domains, scheduling a sequence of jobs is an important function contributing to the overall efficiency of the operation. At Boeing, we develop schedules for many different domains, including assembly of military and commercial aircraft, weapons systems, and space vehicles. Boeing is under contract to develop scheduling systems for the Space Station Payload Planning System (PPS) and Payload Operations and Integration Center (POIC). These applications require that we respect certain sequencing restrictions among the jobs to be scheduled while at the same time assigning resources to the jobs. We call this general problem scheduling and resource allocation. Genetic algorithms (GA's) offer a search method that uses a population of solutions and benefits from intrinsic parallelism to search the problem space rapidly, producing near-optimal solutions. Good intermediate solutions are probabalistically recombined to produce better offspring (based upon some application specific measure of solution fitness, e.g., minimum flowtime, or schedule completeness). Also, at any point in the search, any intermediate solution can be accepted as a final solution; allowing the search to proceed longer usually produces a better solution while terminating the search at virtually any time may yield an acceptable solution. Many processes are constrained by restrictions of sequence among the individual jobs. For a specific job, other jobs must be completed beforehand. While there are obviously many other constraints on processes, it is these on which we focussed for this research: how to allocate crews to jobs while satisfying job precedence requirements and personnel, and tooling and fixture (or, more generally, resource) requirements.

  15. User requirements for a patient scheduling system

    NASA Technical Reports Server (NTRS)

    Zimmerman, W.

    1979-01-01

    A rehabilitation institute's needs and wants from a scheduling system were established by (1) studying the existing scheduling system and the variables that affect patient scheduling, (2) conducting a human-factors study to establish the human interfaces that affect patients' meeting prescribed therapy schedules, and (3) developing and administering a questionnaire to the staff which pertains to the various interface problems in order to identify staff requirements to minimize scheduling problems and other factors that may limit the effectiveness of any new scheduling system.

  16. A heuristic approach to incremental and reactive scheduling

    NASA Technical Reports Server (NTRS)

    Odubiyi, Jide B.; Zoch, David R.

    1989-01-01

    An heuristic approach to incremental and reactive scheduling is described. Incremental scheduling is the process of modifying an existing schedule if the initial schedule does not meet its stated initial goals. Reactive scheduling occurs in near real-time in response to changes in available resources or the occurrence of targets of opportunity. Only minor changes are made during both incremental and reactive scheduling because a goal of re-scheduling procedures is to minimally impact the schedule. The described heuristic search techniques, which are employed by the Request Oriented Scheduling Engine (ROSE), a prototype generic scheduler, efficiently approximate the cost of reaching a goal from a given state and effective mechanisms for controlling search.

  17. Scheduling from the perspective of the application

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Berman, F.; Wolski, R.

    1996-12-31

    Metacomputing is the aggregation of distributed and high-performance resources on coordinated networks. With careful scheduling, resource-intensive applications can be implemented efficiently on metacomputing systems at the sizes of interest to developers and users. In this paper we focus on the problem of scheduling applications on metacomputing systems. We introduce the concept of application-centric scheduling in which everything about the system is evaluated in terms of its impact on the application. Application-centric scheduling is used by virtually all metacomputer programmers to achieve performance on metacomputing systems. We describe two successful metacomputing applications to illustrate this approach, and describe AppLeS scheduling agentsmore » which generalize the application-centric scheduling approach. Finally, we show preliminary results which compare AppLeS-derived schedules with conventional strip and blocked schedules for a two-dimensional Jacobi code.« less

  18. Constraint-Based Scheduling System

    NASA Technical Reports Server (NTRS)

    Zweben, Monte; Eskey, Megan; Stock, Todd; Taylor, Will; Kanefsky, Bob; Drascher, Ellen; Deale, Michael; Daun, Brian; Davis, Gene

    1995-01-01

    Report describes continuing development of software for constraint-based scheduling system implemented eventually on massively parallel computer. Based on machine learning as means of improving scheduling. Designed to learn when to change search strategy by analyzing search progress and learning general conditions under which resource bottleneck occurs.

  19. Gain scheduling - Potential hazards and possible remedies

    NASA Technical Reports Server (NTRS)

    Shamma, Jeff S.; Athans, Michael

    1991-01-01

    A common gain scheduling rule-of-thumb is to schedule on a slow variable. In this work, it is shown how current gain scheduling practice is necessarily limited to slow variations in the scheduling variable. These limitations are revealed to be consequences of fundamental control concepts. Furthermore, it is shown how a formulation of the gain scheduling procedure can lead toward ultimately removing these restrictions.

  20. Product Use Scheduler: A Scheduling Module used in EPA’s Human Exposure Model

    EPA Science Inventory

    The scheduling model (SM) was developed for scheduling the use of consumer products in the U.S. EPA’s Human Exposure Model (HEM), an integrated modeling system to estimate human exposure to chemicals in household consumer products. The SM begins with year-long daily activit...

  1. Scheduling Software for Complex Scenarios

    NASA Technical Reports Server (NTRS)

    2006-01-01

    Preparing a vehicle and its payload for a single launch is a complex process that involves thousands of operations. Because the equipment and facilities required to carry out these operations are extremely expensive and limited in number, optimal assignment and efficient use are critically important. Overlapping missions that compete for the same resources, ground rules, safety requirements, and the unique needs of processing vehicles and payloads destined for space impose numerous constraints that, when combined, require advanced scheduling. Traditional scheduling systems use simple algorithms and criteria when selecting activities and assigning resources and times to each activity. Schedules generated by these simple decision rules are, however, frequently far from optimal. To resolve mission-critical scheduling issues and predict possible problem areas, NASA historically relied upon expert human schedulers who used their judgment and experience to determine where things should happen, whether they will happen on time, and whether the requested resources are truly necessary.

  2. NASA Instrument Cost/Schedule Model

    NASA Technical Reports Server (NTRS)

    Habib-Agahi, Hamid; Mrozinski, Joe; Fox, George

    2011-01-01

    NASA's Office of Independent Program and Cost Evaluation (IPCE) has established a number of initiatives to improve its cost and schedule estimating capabilities. 12One of these initiatives has resulted in the JPL developed NASA Instrument Cost Model. NICM is a cost and schedule estimator that contains: A system level cost estimation tool; a subsystem level cost estimation tool; a database of cost and technical parameters of over 140 previously flown remote sensing and in-situ instruments; a schedule estimator; a set of rules to estimate cost and schedule by life cycle phases (B/C/D); and a novel tool for developing joint probability distributions for cost and schedule risk (Joint Confidence Level (JCL)). This paper describes the development and use of NICM, including the data normalization processes, data mining methods (cluster analysis, principal components analysis, regression analysis and bootstrap cross validation), the estimating equations themselves and a demonstration of the NICM tool suite.

  3. 15 CFR 30.61 - Statistical classification schedules.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 15 Commerce and Foreign Trade 1 2011-01-01 2011-01-01 false Statistical classification schedules... § 30.61 Statistical classification schedules. The following statistical classification schedules are....census.gov/trade. (a) Schedule B—Statistical Classification for Domestic and Foreign Commodities Exported...

  4. 15 CFR 30.61 - Statistical classification schedules.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Statistical classification schedules... § 30.61 Statistical classification schedules. The following statistical classification schedules are....census.gov/trade. (a) Schedule B—Statistical Classification for Domestic and Foreign Commodities Exported...

  5. Rectal cancer delivery of radiotherapy in adequate time and with adequate dose is influenced by treatment center, treatment schedule, and gender and is prognostic parameter for local control: Results of study CAO/ARO/AIO-94

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Fietkau, Rainer; Roedel, Claus; Hohenberger, Werner

    2007-03-15

    Purpose: The impact of the delivery of radiotherapy (RT) on treatment results in rectal cancer patients is unknown. Methods and Materials: The data from 788 patients with rectal cancer treated within the German CAO/AIO/ARO-94 phase III trial were analyzed concerning the impact of the delivery of RT (adequate RT: minimal radiation RT dose delivered, 4300 cGy for neoadjuvant RT or 4700 cGy for adjuvant RT; completion of RT in <44 days for neoadjuvant RT or <49 days for adjuvant RT) in different centers on the locoregional recurrence rate (LRR) and disease-free survival (DFS) at 5 years. The LRR, DFS, andmore » delivery of RT were analyzed as endpoints in multivariate analysis. Results: A significant difference was found between the centers and the delivery of RT. The overall delivery of RT was a prognostic factor for the LRR (no RT, 29.6% {+-} 7.8%; inadequate RT, 21.2% {+-} 5.6%; adequate RT, 6.8% {+-} 1.4%; p = 0.0001) and DFS (no RT, 55.1% {+-} 9.1%; inadequate RT, 57.4% {+-} 6.3%; adequate RT, 69.1% {+-} 2.3%; p = 0.02). Postoperatively, delivery of RT was a prognostic factor for LRR on multivariate analysis (together with pathologic stage) but not for DFS (independent parameters, pathologic stage and age). Preoperatively, on multivariate analysis, pathologic stage, but not delivery of RT, was an independent prognostic parameter for LRR and DFS (together with adequate chemotherapy). On multivariate analysis, the treatment center, treatment schedule (neoadjuvant vs. adjuvant RT), and gender were prognostic parameters for adequate RT. Conclusion: Delivery of RT should be regarded as a prognostic factor for LRR in rectal cancer and is influenced by the treatment center, treatment schedule, and patient gender.« less

  6. Adapting immunisation schedules for children undergoing chemotherapy.

    PubMed

    Fernández-Prada, María; Rodríguez-Martínez, María; García-García, Rebeca; García-Corte, María Dolores; Martínez-Ortega, Carmen

    2018-02-01

    Children undergoing chemotherapy for cancer have special vaccination needs after completion of the treatment. The aim of this study was to evaluate the adaptation of post-chemotherapy vaccination schedules. An observational study was performed on a retrospective cohort that included all children aged from 0 to 14 years, who completed chemotherapy in a tertiary hospital between 2009 and 2015. Inclusion and exclusion criteria were applied. Immunisation was administered in accordance with the guidelines of the Vaccine Advisory Committee of the Spanish Association of Paediatrics. Primary Care immunisation and clinical records of the Preventive Medicine and Public Health Department were reviewed. Of the 99 children who had received chemotherapy, 51 (70.6% males) were included in the study. As regards the type of tumour, 54.9% had a solid organ tumour, and 45.1% had a haematological tumour. Post-chemotherapy immunisation was administered to 70.6%. The most common vaccines received were: diphtheria-tetanus-pertussis or diphtheria-tetanus (54.9%), meningococcus C (41.2%), and seasonal influenza (39.2%). The rate of adaptation of the immunisation schedule after chemotherapy was 9.8%. The pneumococcal conjugate vaccine against 7v or 13v was administered to 21.6% of study subjects. However, only 17.6% received polysaccharide 23v. None received vaccination against hepatitis A. No statistically significant differences were observed between adherence to immunisation schedules and type of tumour (P=.066), gender (P=.304), or age (P=.342). Post-chemotherapy immunisation of children with cancer is poor. The participation of health professionals in training programs and referral of paediatric cancer patients to Vaccine Units could improve the rate of schedule adaptation and proper immunisation of this population. Copyright © 2016 Elsevier España, S.L.U. and Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica. All rights reserved.

  7. A Prospective Cohort Study to Compare Treatment Results Between 2 Fractionation Schedules of High-Dose-Rate Intracavitary Brachytherapy (HDR-ICBT) in Patients With Cervical Cancer

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Huang, Eng-Yen; School of Traditional Chinese Medicine, Chang Gung University College of Medicine, Taiwan; Sun, Li-Min

    Purpose: To compare the treatment results of 2 fractionation schedules for high-dose-rate intracavitary brachytherapy (HDR-ICBT) in patients with cervical cancer. Methods and Materials: From June 2001 through January 2008, 267 patients with stage IB-IVA cervical cancer were enrolled in the study. All patients underwent 4-field pelvic irradiation and HDR-ICBT. The median central and parametrial doses were 39.6 Gy and 45 Gy, respectively. Patient underwent either 6 Gy Multiplication-Sign 4 (HDR-4) (n=144) or 4.5 Gy Multiplication-Sign 6 (HDR-6) (n=123) to point A of ICBT using {sup 192}Ir isotope twice weekly. The rates of overall survival, locoregional failure, distant metastasis, proctitis, cystitis,more » and enterocolitis were compared between HDR-4 and HDR-6. Results: There were no significant differences in the demographic data between HDR-4 and HDR-6 except for total treatment time. The 5-year proctitis rates were 23.0% and 21.5% in HDR-4 and HDR-6 (P=.399), respectively. The corresponding rates of grade 2-4 proctitis were 18.7% and 9.6% (P=.060). The corresponding rates of grades 3-4 proctitis were 5.2% and 1.3% (P=.231). Subgroup analysis revealed that HDR-4 significantly increased grade 2-4 proctitis in patients aged {>=}62 years old (P=.012) but not in patients aged <62 years (P=.976). The rates of overall survival, locoregional failure, distant metastasis, cystitis, and enterocolitis were not significantly different between HDR-4 and HDR-6 schedules. Conclusion: The small fraction size of HDR-ICBT is associated with grade 2 proctitis without compromise of prognosis in elderly patients. This schedule is suggested for patients who tolerate an additional 2 applications of HDR-ICBT.« less

  8. A System for Automatically Generating Scheduling Heuristics

    NASA Technical Reports Server (NTRS)

    Morris, Robert

    1996-01-01

    The goal of this research is to improve the performance of automated schedulers by designing and implementing an algorithm by automatically generating heuristics by selecting a schedule. The particular application selected by applying this method solves the problem of scheduling telescope observations, and is called the Associate Principal Astronomer. The input to the APA scheduler is a set of observation requests submitted by one or more astronomers. Each observation request specifies an observation program as well as scheduling constraints and preferences associated with the program. The scheduler employs greedy heuristic search to synthesize a schedule that satisfies all hard constraints of the domain and achieves a good score with respect to soft constraints expressed as an objective function established by an astronomer-user.

  9. Evolution of resistance to anti-cancer therapy during general dosing schedules

    PubMed Central

    Foo, Jasmine; Michor, Franziska

    2009-01-01

    Anti-cancer drugs targeted to specific oncogenic pathways have shown promising therapeutic results in the past few years; however, drug resistance remains an important obstacle for these therapies. Resistance to these drugs can emerge due to a variety of reasons including genetic or epigenetic changes which alter the binding site of the drug target, cellular metabolism or export mechanisms. Obtaining a better understanding of the evolution of resistant populations during therapy may enable the design of more effective therapeutic regimens which prevent or delay progression of disease due to resistance. In this paper, we use stochastic mathematical models to study the evolutionary dynamics of resistance under time-varying dosing schedules and pharmacokinetic effects. The populations of sensitive and resistant cells are modeled as multi-type non-homogeneous birth-death processes in which the drug concentration affects the birth and death rates of both the sensitive and resistant cell populations in continuous time. This flexible model allows us to consider the effects of generalized treatment strategies as well as detailed pharmacokinetic phenomena such as drug elimination and accumulation over multiple doses. We develop estimates for the probability of developing resistance and moments of the size of the resistant cell population. With these estimates, we optimize treatment schedules over a subspace of tolerated schedules to minimize the risk of disease progression due to resistance as well as locate ideal schedules for controlling the population size of resistant clones in situations where resistance is inevitable. Our methodology can be used to describe dynamics of resistance arising due to a single (epi)genetic alteration in any tumor type. PMID:20004211

  10. Applying dynamic priority scheduling scheme to static systems of pinwheel task model in power-aware scheduling.

    PubMed

    Seol, Ye-In; Kim, Young-Kuk

    2014-01-01

    Power-aware scheduling reduces CPU energy consumption in hard real-time systems through dynamic voltage scaling (DVS). In this paper, we deal with pinwheel task model which is known as static and predictable task model and could be applied to various embedded or ubiquitous systems. In pinwheel task model, each task's priority is static and its execution sequence could be predetermined. There have been many static approaches to power-aware scheduling in pinwheel task model. But, in this paper, we will show that the dynamic priority scheduling results in power-aware scheduling could be applied to pinwheel task model. This method is more effective than adopting the previous static priority scheduling methods in saving energy consumption and, for the system being still static, it is more tractable and applicable to small sized embedded or ubiquitous computing. Also, we introduce a novel power-aware scheduling algorithm which exploits all slacks under preemptive earliest-deadline first scheduling which is optimal in uniprocessor system. The dynamic priority method presented in this paper could be applied directly to static systems of pinwheel task model. The simulation results show that the proposed algorithm with the algorithmic complexity of O(n) reduces the energy consumption by 10-80% over the existing algorithms.

  11. Applying Dynamic Priority Scheduling Scheme to Static Systems of Pinwheel Task Model in Power-Aware Scheduling

    PubMed Central

    2014-01-01

    Power-aware scheduling reduces CPU energy consumption in hard real-time systems through dynamic voltage scaling (DVS). In this paper, we deal with pinwheel task model which is known as static and predictable task model and could be applied to various embedded or ubiquitous systems. In pinwheel task model, each task's priority is static and its execution sequence could be predetermined. There have been many static approaches to power-aware scheduling in pinwheel task model. But, in this paper, we will show that the dynamic priority scheduling results in power-aware scheduling could be applied to pinwheel task model. This method is more effective than adopting the previous static priority scheduling methods in saving energy consumption and, for the system being still static, it is more tractable and applicable to small sized embedded or ubiquitous computing. Also, we introduce a novel power-aware scheduling algorithm which exploits all slacks under preemptive earliest-deadline first scheduling which is optimal in uniprocessor system. The dynamic priority method presented in this paper could be applied directly to static systems of pinwheel task model. The simulation results show that the proposed algorithm with the algorithmic complexity of O(n) reduces the energy consumption by 10–80% over the existing algorithms. PMID:25121126

  12. Production scheduling with ant colony optimization

    NASA Astrophysics Data System (ADS)

    Chernigovskiy, A. S.; Kapulin, D. V.; Noskova, E. E.; Yamskikh, T. N.; Tsarev, R. Yu

    2017-10-01

    The optimum solution of the production scheduling problem for manufacturing processes at an enterprise is crucial as it allows one to obtain the required amount of production within a specified time frame. Optimum production schedule can be found using a variety of optimization algorithms or scheduling algorithms. Ant colony optimization is one of well-known techniques to solve the global multi-objective optimization problem. In the article, the authors present a solution of the production scheduling problem by means of an ant colony optimization algorithm. A case study of the algorithm efficiency estimated against some others production scheduling algorithms is presented. Advantages of the ant colony optimization algorithm and its beneficial effect on the manufacturing process are provided.

  13. Artificial intelligence approaches to astronomical observation scheduling

    NASA Technical Reports Server (NTRS)

    Johnston, Mark D.; Miller, Glenn

    1988-01-01

    Automated scheduling will play an increasing role in future ground- and space-based observatory operations. Due to the complexity of the problem, artificial intelligence technology currently offers the greatest potential for the development of scheduling tools with sufficient power and flexibility to handle realistic scheduling situations. Summarized here are the main features of the observatory scheduling problem, how artificial intelligence (AI) techniques can be applied, and recent progress in AI scheduling for Hubble Space Telescope.

  14. Explanation of Registration Review Schedule

    EPA Pesticide Factsheets

    Updated information on EPA's schedule for opening dockets to begin pesticide registration reviews during the next several years. The schedule is subdivided into conventional pesticides, antimicrobials, biochemicals, and microbials.

  15. Alternative Work Schedules: Definitions

    ERIC Educational Resources Information Center

    Journal of the College and University Personnel Association, 1977

    1977-01-01

    The term "alternative work schedules" encompasses any variation of the requirement that all permanent employees in an organization or one shift of employees adhere to the same five-day, seven-to-eight-hour schedule. This article defines staggered hours, flexible working hours (flexitour and gliding time), compressed work week, the task system, and…

  16. 40 CFR 52.1425 - Compliance schedules.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 4 2011-07-01 2011-07-01 false Compliance schedules. 52.1425 Section...) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS (CONTINUED) Nebraska § 52.1425 Compliance schedules. (a) The compliance schedules for the sources identified below are approved as revisions to the plan...

  17. Scheduling Real-Time Mixed-Criticality Jobs

    NASA Astrophysics Data System (ADS)

    Baruah, Sanjoy K.; Bonifaci, Vincenzo; D'Angelo, Gianlorenzo; Li, Haohan; Marchetti-Spaccamela, Alberto; Megow, Nicole; Stougie, Leen

    Many safety-critical embedded systems are subject to certification requirements; some systems may be required to meet multiple sets of certification requirements, from different certification authorities. Certification requirements in such "mixed-criticality" systems give rise to interesting scheduling problems, that cannot be satisfactorily addressed using techniques from conventional scheduling theory. In this paper, we study a formal model for representing such mixed-criticality workloads. We demonstrate first the intractability of determining whether a system specified in this model can be scheduled to meet all its certification requirements, even for systems subject to two sets of certification requirements. Then we quantify, via the metric of processor speedup factor, the effectiveness of two techniques, reservation-based scheduling and priority-based scheduling, that are widely used in scheduling such mixed-criticality systems, showing that the latter of the two is superior to the former. We also show that the speedup factors are tight for these two techniques.

  18. A space station onboard scheduling assistant

    NASA Technical Reports Server (NTRS)

    Brindle, A. F.; Anderson, B. H.

    1988-01-01

    One of the goals for the Space Station is to achieve greater autonomy, and have less reliance on ground commanding than previous space missions. This means that the crew will have to take an active role in scheduling and rescheduling their activities onboard, perhaps working from preliminary schedules generated on the ground. Scheduling is a time intensive task, whether performed manually or automatically, so the best approach to solving onboard scheduling problems may involve crew members working with an interactive software scheduling package. A project is described which investigates a system that uses knowledge based techniques for the rescheduling of experiments within the Materials Technology Laboratory of the Space Station. Particular attention is paid to: (1) methods for rapid response rescheduling to accommodate unplanned changes in resource availability, (2) the nature of the interface to the crew, (3) the representation of the many types of data within the knowledge base, and (4) the possibility of applying rule-based and constraint-based reasoning methods to onboard activity scheduling.

  19. Development of Watch Schedule Using Rules Approach

    NASA Astrophysics Data System (ADS)

    Jurkevicius, Darius; Vasilecas, Olegas

    The software for schedule creation and optimization solves a difficult, important and practical problem. The proposed solution is an online employee portal where administrator users can create and manage watch schedules and employee requests. Each employee can login with his/her own account and see his/her assignments, manage requests, etc. Employees set as administrators can perform the employee scheduling online, manage requests, etc. This scheduling software allows users not only to see the initial and optimized watch schedule in a simple and understandable form, but also to create special rules and criteria and input their business. The system using rules automatically will generate watch schedule.

  20. An algorithm for a single machine scheduling problem with sequence dependent setup times and scheduling windows

    NASA Technical Reports Server (NTRS)

    Moore, J. E.

    1975-01-01

    An enumeration algorithm is presented for solving a scheduling problem similar to the single machine job shop problem with sequence dependent setup times. The scheduling problem differs from the job shop problem in two ways. First, its objective is to select an optimum subset of the available tasks to be performed during a fixed period of time. Secondly, each task scheduled is constrained to occur within its particular scheduling window. The algorithm is currently being used to develop typical observational timelines for a telescope that will be operated in earth orbit. Computational times associated with timeline development are presented.

  1. Technology for planning and scheduling under complex constraints

    NASA Astrophysics Data System (ADS)

    Alguire, Karen M.; Pedro Gomes, Carla O.

    1997-02-01

    Within the context of law enforcement, several problems fall into the category of planning and scheduling under constraints. Examples include resource and personnel scheduling, and court scheduling. In the case of court scheduling, a schedule must be generated considering available resources, e.g., court rooms and personnel. Additionally, there are constraints on individual court cases, e.g., temporal and spatial, and between different cases, e.g., precedence. Finally, there are overall objectives that the schedule should satisfy such as timely processing of cases and optimal use of court facilities. Manually generating a schedule that satisfies all of the constraints is a very time consuming task. As the number of court cases and constraints increases, this becomes increasingly harder to handle without the assistance of automatic scheduling techniques. This paper describes artificial intelligence (AI) technology that has been used to develop several high performance scheduling applications including a military transportation scheduler, a military in-theater airlift scheduler, and a nuclear power plant outage scheduler. We discuss possible law enforcement applications where we feel the same technology could provide long-term benefits to law enforcement agencies and their operations personnel.

  2. Registration Review Docket Opening Schedule

    EPA Pesticide Factsheets

    Dockets are opened on a fiscal year schedule for reevaluation of all pesticides. They are subdivided into conventional pesticides, antimicrobials, biochemicals, and microbials. The schedules for 2014 to 2017 are attached.

  3. Enhanced Software for Scheduling Space-Shuttle Processing

    NASA Technical Reports Server (NTRS)

    Barretta, Joseph A.; Johnson, Earl P.; Bierman, Rocky R.; Blanco, Juan; Boaz, Kathleen; Stotz, Lisa A.; Clark, Michael; Lebovitz, George; Lotti, Kenneth J.; Moody, James M.; hide

    2004-01-01

    The Ground Processing Scheduling System (GPSS) computer program is used to develop streamlined schedules for the inspection, repair, and refurbishment of space shuttles at Kennedy Space Center. A scheduling computer program is needed because space-shuttle processing is complex and it is frequently necessary to modify schedules to accommodate unanticipated events, unavailability of specialized personnel, unexpected delays, and the need to repair newly discovered defects. GPSS implements constraint-based scheduling algorithms and provides an interactive scheduling software environment. In response to inputs, GPSS can respond with schedules that are optimized in the sense that they contain minimal violations of constraints while supporting the most effective and efficient utilization of space-shuttle ground processing resources. The present version of GPSS is a product of re-engineering of a prototype version. While the prototype version proved to be valuable and versatile as a scheduling software tool during the first five years, it was characterized by design and algorithmic deficiencies that affected schedule revisions, query capability, task movement, report capability, and overall interface complexity. In addition, the lack of documentation gave rise to difficulties in maintenance and limited both enhanceability and portability. The goal of the GPSS re-engineering project was to upgrade the prototype into a flexible system that supports multiple- flow, multiple-site scheduling and that retains the strengths of the prototype while incorporating improvements in maintainability, enhanceability, and portability.

  4. 12 CFR 229.12 - Availability schedule.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Availability schedule. 229.12 Section 229.12 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM... Availability Policies § 229.12 Availability schedule. (a) Effective date. The availability schedule contained...

  5. 40 CFR 52.1335 - Compliance schedules.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 4 2011-07-01 2011-07-01 false Compliance schedules. 52.1335 Section...) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS (CONTINUED) Missouri § 52.1335 Compliance schedules. (a) The compliance schedule for the source identified below is approved as a revision to the plan pursuant...

  6. Binary Trees and Parallel Scheduling Algorithms.

    DTIC Science & Technology

    1980-09-01

    been pro- cessed for p. time units. If a job does not complete by its due time, it is tardy. In a nonpreemptive schedule, job i is scheduled to process...the preemptive schedule obtained by the algorithm of section 2.1.2 also minimizes 5Ti, this problem is easily solved in parallel. When lci is to e...August 1978, pp. 657-661. 14. Horn, W. A., "Some simple scheduling algorithms," Naval Res. Logist . Qur., Vol. 21, pp. 177-185, 1974. i5. Hforowitz, E

  7. Trimester Schedule. Research Brief

    ERIC Educational Resources Information Center

    Education Partnerships, Inc., 2012

    2012-01-01

    Why do a trimester schedule? With the advent of block scheduling, many high schools conducted research on utilizing that plan in a trimester format. There appeared to be three issues that most schools faced: (1) How to provide substantive instructional time that was not fragmented?; (2) How does the school climate contribute positively to…

  8. Schedule-induced polydipsia: a rat model of obsessive-compulsive disorder.

    PubMed

    Platt, Brian; Beyer, Chad E; Schechter, Lee E; Rosenzweig-Lipson, Sharon

    2008-04-01

    Obsessive-compulsive disorder (OCD) is difficult to model in animals due to the involvement of both mental (obsessions) and physical (compulsions) symptoms. Due to limitations of using animals to evaluate obsessions, OCD models are limited to evaluation of the compulsive and repetitive behaviors of animals. Of these, models of adjunctive behaviors offer the most value in regard to predicting efficacy of anti-OCD drugs in the clinic. Adjunctive behaviors are those that are maintained indirectly by the variables that control another behavior, rather than directly by their own typical controlling variables. Schedule-induced polydipsia (SIP) is an adjunctive model in which rats exhibit exaggerated drinking behavior (polydipsia) when presented with food pellets under a fixed-time schedule. The polydipsic response is an excessive manifestation of a normal behavior (drinking), providing face validity to the model. Furthermore, clinically effective drugs for the treatment of OCD decrease SIP. This protocol describes a rat SIP model of OCD and provides preclinical data for drugs that decrease polydipsia and are clinically effective in the treatment of OCD.

  9. 19 CFR 162.45a - Summary forfeiture of Schedule I and Schedule II controlled substances.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) INSPECTION, SEARCH, AND SEIZURE....S.C. 965. Accordingly, in the case of a seizure of Schedule I or Schedule II controlled substances...

  10. 40 CFR 141.702 - Sampling schedules.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 23 2011-07-01 2011-07-01 false Sampling schedules. 141.702 Section... Monitoring Requirements § 141.702 Sampling schedules. (a) Systems required to conduct source water monitoring under § 141.701 must submit a sampling schedule that specifies the calendar dates when the system will...

  11. 40 CFR 141.702 - Sampling schedules.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 22 2010-07-01 2010-07-01 false Sampling schedules. 141.702 Section... Monitoring Requirements § 141.702 Sampling schedules. (a) Systems required to conduct source water monitoring under § 141.701 must submit a sampling schedule that specifies the calendar dates when the system will...

  12. Scheduling lessons learned from the Autonomous Power System

    NASA Technical Reports Server (NTRS)

    Ringer, Mark J.

    1992-01-01

    The Autonomous Power System (APS) project at NASA LeRC is designed to demonstrate the applications of integrated intelligent diagnosis, control, and scheduling techniques to space power distribution systems. The project consists of three elements: the Autonomous Power Expert System (APEX) for Fault Diagnosis, Isolation, and Recovery (FDIR); the Autonomous Intelligent Power Scheduler (AIPS) to efficiently assign activities start times and resources; and power hardware (Brassboard) to emulate a space-based power system. The AIPS scheduler was tested within the APS system. This scheduler is able to efficiently assign available power to the requesting activities and share this information with other software agents within the APS system in order to implement the generated schedule. The AIPS scheduler is also able to cooperatively recover from fault situations by rescheduling the affected loads on the Brassboard in conjunction with the APEX FDIR system. AIPS served as a learning tool and an initial scheduling testbed for the integration of FDIR and automated scheduling systems. Many lessons were learned from the AIPS scheduler and are now being integrated into a new scheduler called SCRAP (Scheduler for Continuous Resource Allocation and Planning). This paper will service three purposes: an overview of the AIPS implementation, lessons learned from the AIPS scheduler, and a brief section on how these lessons are being applied to the new SCRAP scheduler.

  13. Incremental Scheduling Engines: Cost Savings through Automation

    NASA Technical Reports Server (NTRS)

    Jaap, John; Phillips, Shaun

    2005-01-01

    As humankind embarks on longer space missions farther from home, the requirements and environments for scheduling the activities performed on these missions are changing. As we begin to prepare for these missions it is appropriate to evaluate the merits and applicability of the different types of scheduling engines. Scheduling engines temporally arrange tasks onto a timeline so that all constraints and ob.jectives are met and resources are not over-booked. Scheduling engines used to schedule space missions fall into three general categories: batch, mixed-initiative, and incremental. This paper, presents an assessment of the engine types, a discussion of the impact of human exploration of the moon and Mars on planning and scheduling, and the applicability of the different types of scheduling engines. This paper will pursue the hypothesis that incremental scheduling engines may have a place in the new environment; they have the potential to reduce cost, to improve the satisfaction of those who execute or benefit from a particular timeline (the customers), and to allow astronauts to plan their own tasks and those of their companion robots.

  14. Tool for Merging Proposals Into DSN Schedules

    NASA Technical Reports Server (NTRS)

    Khanampornpan, Teerapat; Kwok, John; Call, Jared

    2008-01-01

    A Practical Extraction and Reporting Language (Perl) script called merge7da has been developed to facilitate determination, by a project scheduler in NASA's Deep Space Network, of whether a proposal for use of the DSN could create a conflict with the current DSN schedule. Prior to the development of merge7da, there was no way to quickly identify potential schedule conflicts: it was necessary to submit a proposal and wait a day or two for a response from a DSN scheduling facility. By using merge7da to detect and eliminate potential schedule conflicts before submitting a proposal, a project scheduler saves time and gains assurance that the proposal will probably be accepted. merge7da accepts two input files, one of which contains the current DSN schedule and is in a DSN-standard format called '7da'. The other input file contains the proposal and is in another DSN-standard format called 'C1/C2'. merge7da processes the two input files to produce a merged 7da-format output file that represents the DSN schedule as it would be if the proposal were to be adopted. This 7da output file can be loaded into various DSN scheduling software tools now in use.

  15. Response Strength in Extreme Multiple Schedules

    ERIC Educational Resources Information Center

    McLean, Anthony P.; Grace, Randolph C.; Nevin, John A.

    2012-01-01

    Four pigeons were trained in a series of two-component multiple schedules. Reinforcers were scheduled with random-interval schedules. The ratio of arranged reinforcer rates in the two components was varied over 4 log units, a much wider range than previously studied. When performance appeared stable, prefeeding tests were conducted to assess…

  16. An Expert System for Aviation Squadron Flight Scheduling

    DTIC Science & Technology

    1991-09-01

    SCHEDULING A. OVERVIEW A flight schedule is an organization’s plan to accomplish specific missions with its available resources. It details the mission...schedule for every 24 hour period, and will occasionally write a weekly flight schedule for long range planning purposes. The flight schedule is approved...requirements, and 11 aircraft, trainer, and aircrew availability to formulate the flight schedule. It basically is a plan to optimize the squadron’s resources

  17. Hybrid optimal scheduling for intermittent androgen suppression of prostate cancer

    NASA Astrophysics Data System (ADS)

    Hirata, Yoshito; di Bernardo, Mario; Bruchovsky, Nicholas; Aihara, Kazuyuki

    2010-12-01

    We propose a method for achieving an optimal protocol of intermittent androgen suppression for the treatment of prostate cancer. Since the model that reproduces the dynamical behavior of the surrogate tumor marker, prostate specific antigen, is piecewise linear, we can obtain an analytical solution for the model. Based on this, we derive conditions for either stopping or delaying recurrent disease. The solution also provides a design principle for the most favorable schedule of treatment that minimizes the rate of expansion of the malignant cell population.

  18. Interactive Dynamic Mission Scheduling for ASCA

    NASA Astrophysics Data System (ADS)

    Antunes, A.; Nagase, F.; Isobe, T.

    The Japanese X-ray astronomy satellite ASCA (Advanced Satellite for Cosmology and Astrophysics) mission requires scheduling for each 6-month observation phase, further broken down into weekly schedules at a few minutes resolution. Two tools, SPIKE and NEEDLE, written in Lisp and C, use artificial intelligence (AI) techniques combined with a graphic user interface for fast creation and alteration of mission schedules. These programs consider viewing and satellite attitude constraints as well as observer-requested criteria and present an optimized set of solutions for review by the planner. Six-month schedules at 1 day resolution are created for an oversubscribed set of targets by the SPIKE software, originally written for HST and presently being adapted for EUVE, XTE and AXAF. The NEEDLE code creates weekly schedules at 1 min resolution using in-house orbital routines and creates output for processing by the command generation software. Schedule creation on both the long- and short-term scale is rapid, less than 1 day for long-term, and one hour for short-term.

  19. 5 CFR 532.261 - Special wage schedules for leader and supervisory schedules for leader and supervisory wage...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... supervisory schedules for leader and supervisory wage employees in the Puerto Rico wage area. 532.261 Section... schedules for leader and supervisory wage employees in the Puerto Rico wage area. (a) The Department of... the Puerto Rico wage area. (c) The step 2 rate for the supervisory wage schedule shall be: (1) For...

  20. 5 CFR 532.261 - Special wage schedules for leader and supervisory schedules for leader and supervisory wage...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... supervisory schedules for leader and supervisory wage employees in the Puerto Rico wage area. 532.261 Section... schedules for leader and supervisory wage employees in the Puerto Rico wage area. (a) The Department of... the Puerto Rico wage area. (c) The step 2 rate for the supervisory wage schedule shall be: (1) For...

  1. 5 CFR 532.261 - Special wage schedules for leader and supervisory schedules for leader and supervisory wage...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... supervisory schedules for leader and supervisory wage employees in the Puerto Rico wage area. 532.261 Section... schedules for leader and supervisory wage employees in the Puerto Rico wage area. (a) The Department of... the Puerto Rico wage area. (c) The step 2 rate for the supervisory wage schedule shall be: (1) For...

  2. 5 CFR 532.261 - Special wage schedules for leader and supervisory schedules for leader and supervisory wage...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... supervisory schedules for leader and supervisory wage employees in the Puerto Rico wage area. 532.261 Section... schedules for leader and supervisory wage employees in the Puerto Rico wage area. (a) The Department of... the Puerto Rico wage area. (c) The step 2 rate for the supervisory wage schedule shall be: (1) For...

  3. 5 CFR 532.261 - Special wage schedules for leader and supervisory schedules for leader and supervisory wage...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... supervisory schedules for leader and supervisory wage employees in the Puerto Rico wage area. 532.261 Section... schedules for leader and supervisory wage employees in the Puerto Rico wage area. (a) The Department of... the Puerto Rico wage area. (c) The step 2 rate for the supervisory wage schedule shall be: (1) For...

  4. In-Space Crew-Collaborative Task Scheduling

    NASA Technical Reports Server (NTRS)

    Jaap, John; Meyer, Patrick; Davis, Elizabeth; Richardson, Lea

    2006-01-01

    As humans venture farther from Earth for longer durations, it will become essential for those on the journey to have significant control over the scheduling of their own activities as well as the activities of their companion systems and robots. However, the crew will not do all the scheduling; timelines will be the result of collaboration with ground personnel. Emerging technologies such as in-space message buses, delay-tolerant networks, and in-space internet will be the carriers on which the collaboration rides. Advances in scheduling technology, in the areas of task modeling, scheduling engines, and user interfaces will allow the crew to become virtual scheduling experts. New concepts of operations for producing the timeline will allow the crew and the ground support to collaborate while providing safeguards to ensure that the mission will be effectively accomplished without endangering the systems or personnel.

  5. Phase II Study of Two Weeks on, One Week off Sunitinib Scheduling in Patients With Metastatic Renal Cell Carcinoma.

    PubMed

    Jonasch, Eric; Slack, Rebecca S; Geynisman, Daniel M; Hasanov, Elshad; Milowsky, Matthew I; Rathmell, W Kimryn; Stovall, Summer; Juarez, Donna; Gilchrist, Troy R; Pruitt, Lisa; Ornstein, Moshe C; Plimack, Elizabeth R; Tannir, Nizar M; Rini, Brian I

    2018-06-01

    Purpose Standard frontline treatment of patients with metastatic renal cell carcinoma currently includes sunitinib. A barrier to long-term treatment with sunitinib includes the development of significant adverse effects, including diarrhea, hand-foot syndrome (HFS), and fatigue. This trial assessed the effect of an alternate 2 weeks on, 1 week off (2/1) schedule of sunitinib on toxicity and efficacy in previously untreated patients with metastatic renal cell carcinoma. Methods Patients started with oral administration of 50 mg sunitinib on a 2/1 schedule and underwent schedule and dose alterations if toxicity developed. The primary end point was < 15% grade ≥ 3 fatigue, diarrhea, or HFS. With 60 patients, the upper bound of the CI would fall below the published 4/2 schedule grade ≥ 3 toxicity rate of 25% to 30%. Results Fifty-nine patients were treated between August 2014 and March 2016. Seventy-seven percent were intermediate or poor risk per Memorial Sloan Kettering Cancer Center criteria. With a median follow-up of 17 months, 25% of patients experienced grade 3 fatigue, HFS, or diarrhea; 37% required a dose reduction, and 10% discontinued because of toxicity. The overall response rate was 57%, median progression-free survival was 13.7 months, and median overall survival was not reached. At 12 weeks, Functional Assessment of Cancer Therapy-General scores dropped between 0% and 10% from baseline, with less reduction in patients who continued treatment longer. Conclusion The primary end point of decreased grade 3 toxicity was not met; however, treatment with a 2/1 sunitinib schedule is associated with a lack of grade 4 toxicity, a low patient discontinuation rate, and high efficacy.

  6. A cloud-based electronic medical record for scheduling, tracking, and documenting examinations and treatment of retinopathy of prematurity.

    PubMed

    Arnold, Robert W; Jacob, Jack; Matrix, Zinnia

    2012-01-01

    Screening by neonatologists and staging by ophthalmologists is a cost-effective intervention, but inadvertent missed examinations create a high liability. Paper tracking, bedside schedule reminders, and a computer scheduling and reminder program were compared for speed of input and retrospective missed examination rate. A neonatal intensive care unit (NICU) process was then programmed for cloud-based distribution for inpatient and outpatient retinopathy of prematurity monitoring. Over 11 years, 367 premature infants in one NICU were prospectively monitored. The initial paper system missed 11% of potential examinations, the Windows server-based system missed 2%, and the current cloud-based system missed 0% of potential inpatient and outpatient examinations. Computer input of examinations took the same or less time than paper recording. A computer application with a deliberate NICU process improved the proportion of eligible neonates getting their scheduled eye examinations in a timely manner. Copyright 2012, SLACK Incorporated.

  7. 24 CFR 982.517 - Utility allowance schedule.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... percent or more in the utility rate since the last time the utility allowance schedule was revised. The... allowance schedule to correct any errors, or as necessary to update the schedule. (d) Use of utility...

  8. 24 CFR 982.517 - Utility allowance schedule.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... percent or more in the utility rate since the last time the utility allowance schedule was revised. The... allowance schedule to correct any errors, or as necessary to update the schedule. (d) Use of utility...

  9. 24 CFR 982.517 - Utility allowance schedule.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... percent or more in the utility rate since the last time the utility allowance schedule was revised. The... allowance schedule to correct any errors, or as necessary to update the schedule. (d) Use of utility...

  10. Requirements for the implementation of schedule repair technology in the Experiment Scheduling Program

    NASA Technical Reports Server (NTRS)

    Bullington, Stanley F.

    1992-01-01

    The following list of requirements specifies the proposed revisions to the Experiment Scheduling Program (ESP2) which deal with schedule repair. These requirements are divided into those which are general in nature, those which relate to measurement and analysis functions of the software, those which relate specifically to conflict resolution, and those relating directly to the user interface. (This list is not a complete list of requirements for the user interface, but only a list of those schedule repair requirements which relate to the interface.) Some of the requirements relate only to uses of the software in real-time operations. Others are clearly for future versions of the software, beyond the upcoming revision. In either case, the fact will be clearly stated.

  11. Utilization Bound of Non-preemptive Fixed Priority Schedulers

    NASA Astrophysics Data System (ADS)

    Park, Moonju; Chae, Jinseok

    It is known that the schedulability of a non-preemptive task set with fixed priority can be determined in pseudo-polynomial time. However, since Rate Monotonic scheduling is not optimal for non-preemptive scheduling, the applicability of existing polynomial time tests that provide sufficient schedulability conditions, such as Liu and Layland's bound, is limited. This letter proposes a new sufficient condition for non-preemptive fixed priority scheduling that can be used for any fixed priority assignment scheme. It is also shown that the proposed schedulability test has a tighter utilization bound than existing test methods.

  12. Anchorage Arrival Scheduling Under Off-Nominal Weather Conditions

    NASA Technical Reports Server (NTRS)

    Grabbe, Shon; Chan, William N.; Mukherjee, Avijit

    2012-01-01

    Weather can cause flight diversions, passenger delays, additional fuel consumption and schedule disruptions at any high volume airport. The impacts are particularly acute at the Ted Stevens Anchorage International Airport in Anchorage, Alaska due to its importance as a major international portal. To minimize the impacts due to weather, a multi-stage scheduling process is employed that is iteratively executed, as updated aircraft demand and/or airport capacity data become available. The strategic scheduling algorithm assigns speed adjustments for flights that originate outside of Anchorage Center to achieve the proper demand and capacity balance. Similarly, an internal departure-scheduling algorithm assigns ground holds for pre-departure flights that originate from within Anchorage Center. Tactical flight controls in the form of airborne holding are employed to reactively account for system uncertainties. Real-world scenarios that were derived from the January 16, 2012 Anchorage visibility observations and the January 12, 2012 Anchorage arrival schedule were used to test the initial implementation of the scheduling algorithm in fast-time simulation experiments. Although over 90% of the flights in the scenarios arrived at Anchorage without requiring any delay, pre-departure scheduling was the dominant form of control for Anchorage arrivals. Additionally, tactical scheduling was used extensively in conjunction with the pre-departure scheduling to reactively compensate for uncertainties in the arrival demand. For long-haul flights, the strategic scheduling algorithm performed best when the scheduling horizon was greater than 1,000 nmi. With these long scheduling horizons, it was possible to absorb between ten and 12 minutes of delay through speed control alone. Unfortunately, the use of tactical scheduling, which resulted in airborne holding, was found to increase as the strategic scheduling horizon increased because of the additional uncertainty in the arrival times

  13. OGUPSA sensor scheduling architecture and algorithm

    NASA Astrophysics Data System (ADS)

    Zhang, Zhixiong; Hintz, Kenneth J.

    1996-06-01

    This paper introduces a new architecture for a sensor measurement scheduler as well as a dynamic sensor scheduling algorithm called the on-line, greedy, urgency-driven, preemptive scheduling algorithm (OGUPSA). OGUPSA incorporates a preemptive mechanism which uses three policies, (1) most-urgent-first (MUF), (2) earliest- completed-first (ECF), and (3) least-versatile-first (LVF). The three policies are used successively to dynamically allocate and schedule and distribute a set of arriving tasks among a set of sensors. OGUPSA also can detect the failure of a task to meet a deadline as well as generate an optimal schedule in the sense of minimum makespan for a group of tasks with the same priorities. A side benefit is OGUPSA's ability to improve dynamic load balance among all sensors while being a polynomial time algorithm. Results of a simulation are presented for a simple sensor system.

  14. In-Space Crew-Collaborative Task Scheduling

    NASA Technical Reports Server (NTRS)

    Jaap, John; Meyer, Patrick; Davis, Elizabeth; Richardson, Lea

    2006-01-01

    As humans venture farther from earth for longer durations, it will become essential for those on the journey to have significant control over the scheduling of their own activities as well as the activities of their companion systems and robots. However, there are many reasons why the crew will not do all the scheduling; timelines will be the result of collaboration with ground personnel. Emerging technologies such as in-space message buses, delay-tolerant networks, and in-space internet will be the carriers on which the collaboration rides. Advances in scheduling technology, in the areas of task modeling, scheduling engines, and user interfaces will allow the crew to become virtual scheduling experts. New concepts of operations for producing the timeline will allow the crew and the ground support to collaborate while providing safeguards to ensure that the mission will be effectively accomplished without endangering the systems or personnel.

  15. A sequential erythropoietin and GM-CSF schedule offers clinical benefits in the treatment of anaemia in myelodysplastic syndromes.

    PubMed

    Bernell, P; Stenke, L; Wallvik, J; Hippe, E; Hast, R

    1996-08-01

    In order to reduce anaemia in patients with myelodysplastic syndromes (MDS) a stepwise treatment protocol including erythropoietin (EP) and granulocyte-macrophage colony-stimulating factor (GM-CSF) was designed. Thirty-seven MDS patients (stages I-III) with symptomatic anaemia were first given EPO 10,000 U s.c. 3 times weekly for 6 weeks. Those not responding, i.e. increased their haemoglobin levels > 15 g/l, proceeded into the second phase of the study where GM-CSF (200 micrograms/d. s.c. on weeks 1-6) was combined with EPO (10,000 U s.c. 3 times weekly on weeks 5-14). Following the initial EPO treatment phase, 14 of the 37 patients (38%) responded with increased haemoglobin levels. Responders were significantly different from non-responders in that their pre-treatment values of s-EPO, s-LDH and bone marrow blast cell counts were lower, their baseline haemoglobin levels higher and their transfusion dependency less pronounced. Eighteen of the 23 non-responders proceeded into the second phase, 13 of those were evaluable having completed the entire schedule. Three of the 13 initially EPO resistant patients (23%) responded to the GM-CSF/EPO combination with increased haemoglobin levels, suggesting a positive synergy between the two cytokines. Thus, the overall response rate to the present protocol was 46% (17 of 37 cases), but only a limited subset of the patients did clearly benefit from the combined GM-CSF/EPO administration. Therefore, we believe this step-wise approach to multiple growth factor treatment in MDS, starting with EPO alone and reserving the combination for refractory cases, has considerable advantages, taking into account both medical and socio-economical aspects.

  16. Quantifying and understanding reproductive allocation schedules in plants.

    PubMed

    Wenk, Elizabeth Hedi; Falster, Daniel S

    2015-12-01

    A plant's reproductive allocation (RA) schedule describes the fraction of surplus energy allocated to reproduction as it increases in size. While theorists use RA schedules as the connection between life history and energy allocation, little is known about RA schedules in real vegetation. Here we review what is known about RA schedules for perennial plants using studies either directly quantifying RA or that collected data from which the shape of an RA schedule can be inferred. We also briefly review theoretical models describing factors by which variation in RA may arise. We identified 34 studies from which aspects of an RA schedule could be inferred. Within those, RA schedules varied considerably across species: some species abruptly shift all resources from growth to reproduction; most others gradually shift resources into reproduction, but under a variety of graded schedules. Available data indicate the maximum fraction of energy allocated to production ranges from 0.1 to 1 and that shorter lived species tend to have higher initial RA and increase their RA more quickly than do longer-lived species. Overall, our findings indicate, little data exist about RA schedules in perennial plants. Available data suggest a wide range of schedules across species. Collection of more data on RA schedules would enable a tighter integration between observation and a variety of models predicting optimal energy allocation, plant growth rates, and biogeochemical cycles.

  17. The Effect of Biologically Effective Dose and Radiation Treatment Schedule on Overall Survival in Stage I Non-Small Cell Lung Cancer Patients Treated With Stereotactic Body Radiation Therapy

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Stahl, John M.; Ross, Rudi; Harder, Eileen M.

    Purpose: To determine the effect of biologically effective dose (BED{sub 10}) and radiation treatment schedule on overall survival (OS) in patients with early-stage non-small cell lung cancer (NSCLC) undergoing stereotactic body radiation therapy (SBRT). Methods and Materials: Using data from 65 treatment centers in the United States, we retrospectively reviewed the records of T1-2 N0 NSCLC patients undergoing SBRT alone from 2006 to 2014. Biologically relevant covariates, including dose per fraction, number of fractions, and time between fractions, were used to quantify BED{sub 10} and radiation treatment schedule. The linear-quadratic equation was used to calculate BED{sub 10} and to generatemore » a dichotomous dose variable of <105 Gy versus ≥105 Gy BED{sub 10}. The primary outcome was OS. We used the Kaplan-Meier method, the log–rank test, and Cox proportional hazards regression with propensity score matching to determine whether prescription BED{sub 10} was associated with OS. Results: We identified 747 patients who met inclusion criteria. The median BED{sub 10} was 132 Gy, and 59 (7.7%) had consecutive-day fractions. Median follow-up was 41 months, and 452 patients (60.5%) had died by the conclusion of the study. The 581 patients receiving ≥105 Gy BED{sub 10} had a median survival of 28 months, whereas the 166 patients receiving <105 Gy BED{sub 10} had a median survival of 22 months (log–rank, P=.01). Radiation treatment schedule was not a significant predictor of OS on univariable analysis. After adjusting for T stage, sex, tumor histology, and Eastern Cooperative Oncology Group performance status, BED{sub 10} ≥105 Gy versus <105 Gy remained significantly associated with improved OS (hazard ratio 0.78, 95% confidence interval 0.62-0.98, P=.03). Propensity score matching on imbalanced variables within high- and low-dose cohorts confirmed a survival benefit with higher prescription dose. Conclusions: We found that dose escalation to 105

  18. Job shop scheduling problem with late work criterion

    NASA Astrophysics Data System (ADS)

    Piroozfard, Hamed; Wong, Kuan Yew

    2015-05-01

    Scheduling is considered as a key task in many industries, such as project based scheduling, crew scheduling, flight scheduling, machine scheduling, etc. In the machine scheduling area, the job shop scheduling problems are considered to be important and highly complex, in which they are characterized as NP-hard. The job shop scheduling problems with late work criterion and non-preemptive jobs are addressed in this paper. Late work criterion is a fairly new objective function. It is a qualitative measure and concerns with late parts of the jobs, unlike classical objective functions that are quantitative measures. In this work, simulated annealing was presented to solve the scheduling problem. In addition, operation based representation was used to encode the solution, and a neighbourhood search structure was employed to search for the new solutions. The case studies are Lawrence instances that were taken from the Operations Research Library. Computational results of this probabilistic meta-heuristic algorithm were compared with a conventional genetic algorithm, and a conclusion was made based on the algorithm and problem.

  19. Mission scheduling

    NASA Technical Reports Server (NTRS)

    Gaspin, Christine

    1989-01-01

    How a neural network can work, compared to a hybrid system based on an operations research and artificial intelligence approach, is investigated through a mission scheduling problem. The characteristic features of each system are discussed.

  20. Schedules of Controlled Substances: Extension of Temporary Placement of Three Synthetic Phenethylamines in Schedule I. Final order.

    PubMed

    2015-11-13

    The Administrator of the Drug Enforcement Administration is issuing this final order extending the temporary schedule I status for three synthetic phenethylamines into the Controlled Substances Act pursuant to the temporary scheduling provisions of the Act. The substances are: 2-(4-iodo-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamine (25I-NBOMe; 2C-I-NBOMe; 25I; Cimbi-5), 2-(4-chloro-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamine (25C-NBOMe; 2C-C-NBOMe; 25C; Cimbi-82), and 2-(4-bromo-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamine (25B-NBOMe; 2C-B-NBOMe; 25B; Cimbi-36) [hereinafter 25I-NBOMe, 2C-NBOMe, and 25-NBOMe, respectively]. The initial temporary scheduling was based on a finding by the Deputy Administrator that the placement of these synthetic phenethylamines and their optical, positional, and geometric isomers, salts, and salts of isomers into schedule I of the Controlled Substances Act is necessary to avoid an imminent hazard to the public safety. The current final order temporarily placing 25I-NBOMe, 25C-NBOMe, and 25B-NBOMe in schedule I is due to expire on November 14, 2015. This final order will extend the temporary scheduling of 25I-NBOMe, 25C-NBOMe, and 25B-NBOMe for one year, or until the permanent scheduling action for these three substances is completed, whichever occurs first. As a result of this order, the full effect of the Controlled Substances Act and its implementing regulations, including criminal, civil and administrative penalties, sanctions, and regulatory controls of schedule I substances will be imposed on the manufacture, distribution, possession, importation, and exportation of these synthetic phenethylamines.

  1. 39 CFR 3020.11 - Initial Mail Classification Schedule.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 39 Postal Service 1 2014-07-01 2014-07-01 false Initial Mail Classification Schedule. 3020.11 Section 3020.11 Postal Service POSTAL REGULATORY COMMISSION PERSONNEL PRODUCT LISTS Mail Classification Schedule § 3020.11 Initial Mail Classification Schedule. The initial Mail Classification Schedule shall...

  2. Enabling a New Planning and Scheduling Paradigm

    NASA Technical Reports Server (NTRS)

    Jaap, John; Davis, Elizabeth

    2004-01-01

    The Flight Projects Directorate at NASA's Marshall Space Flight Center is developing a new planning and scheduling environment and a new scheduling algorithm to enable a paradigm shift in planning and scheduling concepts. Over the past 33 years Marshall has developed and evolved a paradigm for generating payload timelines for Skylab, Spacelab, various other Shuttle payloads, and the International Space Station. The current paradigm starts by collecting the requirements, called "tasks models," from the scientists and technologists for the tasks that they want to be done. Because of shortcomings in the current modeling schema, some requirements are entered as notes. Next a cadre with knowledge of vehicle and hardware modifies these models to encompass and be compatible with the hardware model; again, notes are added when the modeling schema does not provide a better way to represent the requirements. Finally, another cadre further modifies the models to be compatible with the scheduling engine. This last cadre also submits the models to the scheduling engine or builds the timeline manually to accommodate requirements that are expressed in notes. A future paradigm would provide a scheduling engine that accepts separate science models and hardware models. The modeling schema would have the capability to represent all the requirements without resorting to notes. Furthermore, the scheduling engine would not require that the models be modified to account for the capabilities (limitations) of the scheduling engine. The enabling technology under development at Marshall has three major components. (1) A new modeling schema allows expressing all the requirements of the tasks without resorting to notes or awkward contrivances. The chosen modeling schema is both maximally expressive and easy to use. It utilizes graphics methods to show hierarchies of task constraints and networks of temporal relationships. (2) A new scheduling algorithm automatically schedules the models

  3. A COTS-Based Attitude Dependent Contact Scheduling System

    NASA Technical Reports Server (NTRS)

    DeGumbia, Jonathan D.; Stezelberger, Shane T.; Woodard, Mark

    2006-01-01

    The mission architecture of the Gamma-ray Large Area Space Telescope (GLAST) requires a sophisticated ground system component for scheduling the downlink of science data. Contacts between the ````````````````` satellite and the Tracking and Data Relay Satellite System (TDRSS) are restricted by the limited field-of-view of the science data downlink antenna. In addition, contacts must be scheduled when permitted by the satellite s complex and non-repeating attitude profile. Complicating the matter further, the long lead-time required to schedule TDRSS services, combined with the short duration of the downlink contact opportunities, mandates accurate GLAST orbit and attitude modeling. These circumstances require the development of a scheduling system that is capable of predictively and accurately modeling not only the orbital position of GLAST but also its attitude. This paper details the methods used in the design of a Commercial Off The Shelf (COTS)-based attitude-dependent. TDRSS contact Scheduling system that meets the unique scheduling requirements of the GLAST mission, and it suggests a COTS-based scheduling approach to support future missions. The scheduling system applies filtering and smoothing algorithms to telemetered GPS data to produce high-accuracy predictive GLAST orbit ephemerides. Next, bus pointing commands from the GLAST Science Support Center are used to model the complexities of the two dynamic science gathering attitude modes. Attitude-dependent view periods are then generated between GLAST and each of the supporting TDRSs. Numerous scheduling constraints are then applied to account for various mission specific resource limitations. Next, an optimization engine is used to produce an optimized TDRSS contact schedule request which is sent to TDRSS scheduling for confirmation. Lastly, the confirmed TDRSS contact schedule is rectified with an updated ephemeris and adjusted bus pointing commands to produce a final science downlink contact schedule.

  4. Scheduling nursing personnel on a microcomputer.

    PubMed

    Liao, C J; Kao, C Y

    1997-01-01

    Suggests that with the shortage of nursing personnel, hospital administrators have to pay more attention to the needs of nurses to retain and recruit them. Also asserts that improving nurses' schedules is one of the most economic ways for the hospital administration to create a better working environment for nurses. Develops an algorithm for scheduling nursing personnel. Contrary to the current hospital approach, which schedules nurses on a person-by-person basis, the proposed algorithm constructs schedules on a day-by-day basis. The algorithm has inherent flexibility in handling a variety of possible constraints and goals, similar to other non-cyclical approaches. But, unlike most other non-cyclical approaches, it can also generate a quality schedule in a short time on a microcomputer. The algorithm was coded in C language and run on a microcomputer. The developed software is currently implemented at a leading hospital in Taiwan. The response to the initial implementation is quite promising.

  5. Vehicle and driver scheduling for public transit.

    DOT National Transportation Integrated Search

    2009-08-01

    The problem of driver scheduling involves the construction of a legal set of shifts, including allowance : of overtime, which cover the blocks in a particular vehicle schedule. A shift is the work scheduled to be performed by : a driver in one day, w...

  6. A hybrid job-shop scheduling system

    NASA Technical Reports Server (NTRS)

    Hellingrath, Bernd; Robbach, Peter; Bayat-Sarmadi, Fahid; Marx, Andreas

    1992-01-01

    The intention of the scheduling system developed at the Fraunhofer-Institute for Material Flow and Logistics is the support of a scheduler working in a job-shop. Due to the existing requirements for a job-shop scheduling system the usage of flexible knowledge representation and processing techniques is necessary. Within this system the attempt was made to combine the advantages of symbolic AI-techniques with those of neural networks.

  7. Scheduling Dependent Real-Time Activities

    DTIC Science & Technology

    1990-08-01

    dependency relationships in a way that is suitable for all real - time systems . This thesis provides an algorithm, called DASA, that is effective for...scheduling the class of real - time systems known as supervisory control systems. Simulation experiments that account for the time required to make scheduling

  8. Space station payload operations scheduling with ESP2

    NASA Technical Reports Server (NTRS)

    Stacy, Kenneth L.; Jaap, John P.

    1988-01-01

    The Mission Analysis Division of the Systems Analysis and Integration Laboratory at the Marshall Space Flight Center is developing a system of programs to handle all aspects of scheduling payload operations for Space Station. The Expert Scheduling Program (ESP2) is the heart of this system. The task of payload operations scheduling can be simply stated as positioning the payload activities in a mission so that they collect their desired data without interfering with other activities or violating mission constraints. ESP2 is an advanced version of the Experiment Scheduling Program (ESP) which was developed by the Mission Integration Branch beginning in 1979 to schedule Spacelab payload activities. The automatic scheduler in ESP2 is an expert system that embodies the rules that expert planners would use to schedule payload operations by hand. This scheduler uses depth-first searching, backtracking, and forward chaining techniques to place an activity so that constraints (such as crew, resources, and orbit opportunities) are not violated. It has an explanation facility to show why an activity was or was not scheduled at a certain time. The ESP2 user can also place the activities in the schedule manually. The program offers graphical assistance to the user and will advise when constraints are being violated. ESP2 also has an option to identify conflict introduced into an existing schedule by changes to payload requirements, mission constraints, and orbit opportunities.

  9. Schedule of controlled substances; placement of fospropofol into schedule IV. Final rule.

    PubMed

    2009-10-06

    With the issuance of this final rule, the Deputy Administrator of the Drug Enforcement Administration (DEA) places the substance fospropofol, including its salts, isomers and salts of isomers whenever the existence of such salts, isomers, and salts of isomers is possible, into schedule IV of the Controlled Substances Act (CSA). As a result of this rule, the regulatory controls and criminal sanctions of schedule IV will be applicable to the manufacture, distribution, dispensing, importation, and exportation of fospropofol and products containing fospropofol.

  10. A customizable, scalable scheduling and reporting system.

    PubMed

    Wood, Jody L; Whitman, Beverly J; Mackley, Lisa A; Armstrong, Robert; Shotto, Robert T

    2014-06-01

    Scheduling is essential for running a facility smoothly and for summarizing activities in use reports. The Penn State Hershey Clinical Simulation Center has developed a scheduling interface that uses off-the-shelf components, with customizations that adapt to each institution's data collection and reporting needs. The system is designed using programs within the Microsoft Office 2010 suite. Outlook provides the scheduling component, while the reporting is performed using Access or Excel. An account with a calendar is created for the main schedule, with separate resource accounts created for each room within the center. The Outlook appointment form's 2 default tabs are used, in addition to a customized third tab. The data are then copied from the calendar into either a database table or a spreadsheet, where the reports are generated.Incorporating this system into an institution-wide structure allows integration of personnel lists and potentially enables all users to check the schedule from their desktop. Outlook also has a Web-based application for viewing the basic schedule from outside the institution, although customized data cannot be accessed. The scheduling and reporting functions have been used for a year at the Penn State Hershey Clinical Simulation Center. The schedule has increased workflow efficiency, improved the quality of recorded information, and provided more accurate reporting. The Penn State Hershey Clinical Simulation Center's scheduling and reporting system can be adapted easily to most simulation centers and can expand and change to meet future growth with little or no expense to the center.

  11. The Composition of the Master Schedule

    NASA Technical Reports Server (NTRS)

    Thomas, Cynthia C.; Behrend, Dirk; MacMillan, Daniel S.

    2010-01-01

    Over a period of about four months, the IVS Coordinating Center (IVSCC) each year composes the Master Schedule for the IVS observing program of the next calendar year. The process begins in early July when the IVSCC contacts the IVS Network Stations to request information about available station time as well as holiday and maintenance schedules for the upcoming year. Going through various planning stages and a review process with the IVS Observing Program Committee (OPC), the final version of the Master Schedule is posted by early November. We describe the general steps of the composition and illustrate them with the example of the planning for the Master Schedule of the 2010 observing year.

  12. Cure Schedule for Stycast 2651/Catalyst 9.

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kropka, Jamie Michael; McCoy, John D.

    2017-11-01

    The Emerson & Cuming technical data sheet (TDS) for Stycast 2651/Catalyst 9 lists three alternate cure schedules for the material, each of which would result in a different state of reaction and different material properties. Here, a cure schedule that attains full reaction of the material is defined. The use of this cure schedule will eliminate variance in material properties due to changes in the cure state of the material, and the cure schedule will serve as the method to make material prior to characterizing properties. The following recommendation uses one of the schedules within the TDS and adds amore » “post cure” to obtain full reaction.« less

  13. Balancing Authority Cooperation Concepts - Intra-Hour Scheduling

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hunsaker, Matthew; Samaan, Nader; Milligan, Michael

    2013-03-29

    The overall objective of this study was to understand, on an Interconnection-wide basis, the effects intra-hour scheduling compared to hourly scheduling. Moreover, the study sought to understand how the benefits of intra-hour scheduling would change by altering the input assumptions in different scenarios. This report describes results of three separate scenarios with differing key assumptions and comparing the production costs between hourly scheduling and 10-minute scheduling performance. The different scenarios were chosen to provide insight into how the estimated benefits might change by altering input assumptions. Several key assumptions were different in the three scenarios, however most assumptions were similarmore » and/or unchanged among the scenarios.« less

  14. Developing optimal nurses work schedule using integer programming

    NASA Astrophysics Data System (ADS)

    Shahidin, Ainon Mardhiyah; Said, Mohd Syazwan Md; Said, Noor Hizwan Mohamad; Sazali, Noor Izatie Amaliena

    2017-08-01

    Time management is the art of arranging, organizing and scheduling one's time for the purpose of generating more effective work and productivity. Scheduling is the process of deciding how to commit resources between varieties of possible tasks. Thus, it is crucial for every organization to have a good work schedule for their staffs. The job of Ward nurses at hospitals runs for 24 hours every day. Therefore, nurses will be working using shift scheduling. This study is aimed to solve the nurse scheduling problem at an emergency ward of a private hospital. A 7-day work schedule for 7 consecutive weeks satisfying all the constraints set by the hospital will be developed using Integer Programming. The work schedule for the nurses obtained gives an optimal solution where all the constraints are being satisfied successfully.

  15. 77 FR 41258 - FOIA Fee Schedule Update

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-13

    ... DEFENSE NUCLEAR FACILITIES SAFETY BOARD 10 CFR Part 1703 FOIA Fee Schedule Update AGENCY: Defense Nuclear Facilities Safety Board. ACTION: Establishment of FOIA Fee Schedule. SUMMARY: The Defense Nuclear Facilities Safety Board is publishing its Freedom of Information Act (FOIA) Fee Schedule Update pursuant to...

  16. 76 FR 43819 - FOIA Fee Schedule Update

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-22

    ... DEFENSE NUCLEAR FACILITIES SAFETY BOARD 10 CFR Part 1703 FOIA Fee Schedule Update AGENCY: Defense Nuclear Facilities Safety Board. ACTION: Establishment of FOIA Fee Schedule. SUMMARY: The Defense Nuclear Facilities Safety Board is publishing its Freedom of Information Act (FOIA) Fee Schedule Update pursuant to...

  17. Prescribed Travel Schedules for Fatigue Management

    NASA Technical Reports Server (NTRS)

    Whitmire, Alexandra; Johnston, Smith; Lockley, Steven

    2011-01-01

    The NASA Fatigue Management Team is developing recommendations for managing fatigue during travel and for shift work operations, as Clinical Practice Guidelines for the Management of Circadian Desynchrony in ISS Operations. The Guidelines provide the International Space Station (ISS ) flight surgeons and other operational clinicians with evidence-based recommendations for mitigating fatigue and other factors related to sleep loss and circadian desynchronization. As much international travel is involved both before and after flight, the guidelines provide recommendations for: pre-flight training, in-flight operations, and post-flight rehabilitation. The objective of is to standardize the process by which care is provided to crewmembers, ground controllers, and other support personnel such as trainers, when overseas travel or schedule shifting is required. Proper scheduling of countermeasures - light, darkness, melatonin, diet, exercise, and medications - is the cornerstone for facilitating circadian adaptation, improving sleep, enhancing alertness, and optimizing performance. The Guidelines provide, among other things, prescribed travel schedules that outline the specific implementation of these mitigation strategies. Each travel schedule offers evidence based protocols for properly using the NASA identified countermeasures for fatigue. This presentation will describe the travel implementation schedules and how these can be used to alleviate the effects of jet lag and/or schedule shifts.

  18. Utilizing AI in Temporal, Spatial, and Resource Scheduling

    NASA Technical Reports Server (NTRS)

    Stottler, Richard; Kalton, Annaka; Bell, Aaron

    2006-01-01

    Aurora is a software system enabling the rapid, easy solution of complex scheduling problems involving spatial and temporal constraints among operations and scarce resources (such as equipment, workspace, and human experts). Although developed for use in the International Space Station Processing Facility, Aurora is flexible enough that it can be easily customized for application to other scheduling domains and adapted as the requirements change or become more precisely known over time. Aurora s scheduling module utilizes artificial-intelligence (AI) techniques to make scheduling decisions on the basis of domain knowledge, including knowledge of constraints and their relative importance, interdependencies among operations, and possibly frequent changes in governing schedule requirements. Unlike many other scheduling software systems, Aurora focuses on resource requirements and temporal scheduling in combination. For example, Aurora can accommodate a domain requirement to schedule two subsequent operations to locations adjacent to a shared resource. The graphical interface allows the user to quickly visualize the schedule and perform changes reflecting additional knowledge or alterations in the situation. For example, the user might drag the activity corresponding to the start of operations to reflect a late delivery.

  19. Scheduling nurses’ shifts at PGI Cikini Hospital

    NASA Astrophysics Data System (ADS)

    Nainggolan, J. C. T.; Kusumastuti, R. D.

    2018-03-01

    Hospitals play an essential role in the community by providing medical services to the public. In order to provide high quality medical services, hospitals must manage their resources (including nurses) effectively and efficiently. Scheduling of nurses’ work shifts, in particular, is crucial, and must be conducted carefully to ensure availability and fairness. This research discusses the job scheduling system for nurses in PGI Cikini Hospital, Jakarta with Goal Programming approach. The research objectives are to identify nurse scheduling criteria and find the best schedule that can meet the criteria. The model has hospital regulations (including government regulations) as hard constraints, and nurses’ preferences as soft constraints. We gather primary data (hospital regulations and nurses’ preferences) through interviews with three Head Nurses and distributing questionnaires to fifty nurses. The results show that on the best schedule, all hard constraints can be satisfied. However, only two out of four soft constraints are satisfied. Compared to current scheduling practice, the resulting schedule ensures the availability of nurses as it satisfies all hospital’s regulations and it has a higher level of fairness as it can accommodate some of the nurses’ preferences.

  20. Scheduling multimedia services in cloud computing environment

    NASA Astrophysics Data System (ADS)

    Liu, Yunchang; Li, Chunlin; Luo, Youlong; Shao, Yanling; Zhang, Jing

    2018-02-01

    Currently, security is a critical factor for multimedia services running in the cloud computing environment. As an effective mechanism, trust can improve security level and mitigate attacks within cloud computing environments. Unfortunately, existing scheduling strategy for multimedia service in the cloud computing environment do not integrate trust mechanism when making scheduling decisions. In this paper, we propose a scheduling scheme for multimedia services in multi clouds. At first, a novel scheduling architecture is presented. Then, We build a trust model including both subjective trust and objective trust to evaluate the trust degree of multimedia service providers. By employing Bayesian theory, the subjective trust degree between multimedia service providers and users is obtained. According to the attributes of QoS, the objective trust degree of multimedia service providers is calculated. Finally, a scheduling algorithm integrating trust of entities is proposed by considering the deadline, cost and trust requirements of multimedia services. The scheduling algorithm heuristically hunts for reasonable resource allocations and satisfies the requirement of trust and meets deadlines for the multimedia services. Detailed simulated experiments demonstrate the effectiveness and feasibility of the proposed trust scheduling scheme.

  1. NRC comprehensive records disposition schedule. Revision 3

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    NONE

    1998-02-01

    Title 44 US Code, ``Public Printing and Documents,`` regulations issued by the General Service Administration (GSA) in 41 CFR Chapter 101, Subchapter B, ``Management and Use of Information and Records,`` and regulations issued by the National Archives and Records Administration (NARA) in 36 CFR Chapter 12, Subchapter B, ``Records Management,`` require each agency to prepare and issue a comprehensive records disposition schedule that contains the NARA approved records disposition schedules for records unique to the agency and contains the NARA`s General Records Schedules for records common to several or all agencies. The approved records disposition schedules specify the appropriate durationmore » of retention and the final disposition for records created or maintained by the NRC. NUREG-0910, Rev. 3, contains ``NRC`s Comprehensive Records Disposition Schedule,`` and the original authorized approved citation numbers issued by NARA. Rev. 3 incorporates NARA approved changes and additions to the NRC schedules that have been implemented since the last revision dated March, 1992, reflects recent organizational changes implemented at the NRC, and includes the latest version of NARA`s General Records Schedule (dated August 1995).« less

  2. Decomposability and scalability in space-based observatory scheduling

    NASA Technical Reports Server (NTRS)

    Muscettola, Nicola; Smith, Stephen F.

    1992-01-01

    In this paper, we discuss issues of problem and model decomposition within the HSTS scheduling framework. HSTS was developed and originally applied in the context of the Hubble Space Telescope (HST) scheduling problem, motivated by the limitations of the current solution and, more generally, the insufficiency of classical planning and scheduling approaches in this problem context. We first summarize the salient architectural characteristics of HSTS and their relationship to previous scheduling and AI planning research. Then, we describe some key problem decomposition techniques supported by HSTS and underlying our integrated planning and scheduling approach, and we discuss the leverage they provide in solving space-based observatory scheduling problems.

  3. A format for the interchange of scheduling models

    NASA Technical Reports Server (NTRS)

    Jaap, John P.; Davis, Elizabeth K.

    1994-01-01

    In recent years a variety of space-activity schedulers have been developed within the aerospace community. Space-activity schedulers are characterized by their need to handle large numbers of activities which are time-window constrained and make high demands on many scarce resources, but are minimally constrained by predecessor/successor requirements or critical paths. Two needs to exchange data between these schedulers have materialized. First, there is significant interest in comparing and evaluating the different scheduling engines to ensure that the best technology is applied to each scheduling endeavor. Second, there is a developing requirement to divide a single scheduling task among different sites, each using a different scheduler. In fact, the scheduling task for International Space Station Alpha (ISSA) will be distributed among NASA centers and among the international partners. The format used to interchange scheduling data for ISSA will likely use a growth version of the format discussed in this paper. The model interchange format (or MIF, pronounced as one syllable) discussed in this paper is a robust solution to the need to interchange scheduling requirements for space activities. It is highly extensible, human-readable, and can be generated or edited with common text editors. It also serves well the need to support a 'benchmark' data case which can be delivered on any computer platform.

  4. Schedule-Dependent Antiangiogenic and Cytotoxic Effects of Chemotherapy on Vascular Endothelial and Retinoblastoma Cells.

    PubMed

    Winter, Ursula; Mena, Hebe A; Negrotto, Soledad; Arana, Eloisa; Pascual-Pasto, Guillem; Laurent, Viviana; Suñol, Mariona; Chantada, Guillermo L; Carcaboso, Angel M; Schaiquevich, Paula

    2016-01-01

    Current treatment of retinoblastoma involves using the maximum dose of chemotherapy that induces tumor control and is tolerated by patients. The impact of dose and schedule on the cytotoxicity of chemotherapy has not been studied. Our aim was to gain insight into the cytotoxic and antiangiogenic effect of the treatment scheme of chemotherapy used in retinoblastoma by means of different in vitro models and to evaluate potential effects on multi-drug resistance proteins. Two commercial and two patient-derived retinoblastoma cell types and two human vascular endothelial cell types were exposed to increasing concentrations of melphalan or topotecan in a conventional (single exposure) or metronomic (7-day continuous exposure) treatment scheme. The concentration of chemotherapy causing a 50% decrease in cell proliferation (IC50) was determined by MTT and induction of apoptosis was evaluated by flow cytometry. Expression of ABCB1, ABCG2 and ABCC1 after conventional or metronomic treatments was assessed by RT-qPCR. We also evaluated the in vivo response to conventional (0.6 mg/kg once a week for 2 weeks) and metronomic (5 days a week for 2 weeks) topotecan in a retinoblastoma xenograft model. Melphalan and topotecan were cytotoxic to both retinoblastoma and endothelial cells after conventional and metronomic treatments. A significant decrease in the IC50 (median, 13-fold; range: 3-23) was observed following metronomic chemotherapy treatment in retinoblastoma and endothelial cell types compared to conventional treatment (p<0.05). Metronomic topotecan or melphalan significantly inhibited in vitro tube formation in HUVEC and EPC compared to vehicle-treated cells (p<0.05). Both treatment schemes induced apoptosis and/or necrosis in all cell models. No significant difference was observed in the expression of ABCB1, ABCC1 or ABCG2 when comparing cells treated with melphalan or topotecan between treatment schedules at the IC50 or with control cells (p>0.05). In mice, continuous

  5. Job Scheduling Under the Portable Batch System

    NASA Technical Reports Server (NTRS)

    Henderson, Robert L.; Woodrow, Thomas S. (Technical Monitor)

    1995-01-01

    The typical batch queuing system schedules jobs for execution by a set of queue controls. The controls determine from which queues jobs may be selected. Within the queue, jobs are ordered first-in, first-run. This limits the set of scheduling policies available to a site. The Portable Batch System removes this limitation by providing an external scheduling module. This separate program has full knowledge of the available queued jobs, running jobs, and system resource usage. Sites are able to implement any policy expressible in one of several procedural language. Policies may range from "bet fit" to "fair share" to purely political. Scheduling decisions can be made over the full set of jobs regardless of queue or order. The scheduling policy can be changed to fit a wide variety of computing environments and scheduling goals. This is demonstrated by the use of PBS on an IBM SP-2 system at NASA Ames.

  6. Evaluation of Fixed Momentary DRO Schedules under Signaled and Unsignaled Arrangements

    ERIC Educational Resources Information Center

    Hammond, Jennifer L.; Iwata, Brian A.; Fritz, Jennifer N.; Dempsey, Carrie M.

    2011-01-01

    Fixed momentary schedules of differential reinforcement of other behavior (FM DRO) generally have been ineffective as treatment for problem behavior. Because most early research on FM DRO included presentation of a signal at the end of the DRO interval, it is unclear whether the limited effects of FM DRO were due to (a) the momentary response…

  7. Plant operation planning and scheduling

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Jammar, R.J.

    When properly designed, planning and scheduling can actually add millions of dollars per year to the bottom line. Planning and scheduling is a continuum of decisions starting with crude selection and ending with establishing short-term targets for crude processing and blending. It also includes maintaining optimization and operation simulation models. It is thought that conservatively, a refinery may save from $5 million to $10 million a year if it pays more attention to the processes behind proper planning and scheduling. Of course, the amount of savings can reach staggering proportions for companies now at the bottom of the Solomon Associatesmore » Inc. refinery performance ranking.« less

  8. The Ames-Lockheed orbiter processing scheduling system

    NASA Technical Reports Server (NTRS)

    Zweben, Monte; Gargan, Robert

    1991-01-01

    A general purpose scheduling system and its application to Space Shuttle Orbiter Processing at the Kennedy Space Center (KSC) are described. Orbiter processing entails all the inspection, testing, repair, and maintenance necessary to prepare the Shuttle for launch and takes place within the Orbiter Processing Facility (OPF) at KSC, the Vehicle Assembly Building (VAB), and on the launch pad. The problems are extremely combinatoric in that there are thousands of tasks, resources, and other temporal considerations that must be coordinated. Researchers are building a scheduling tool that they hope will be an integral part of automating the planning and scheduling process at KSC. The scheduling engine is domain independent and is also being applied to Space Shuttle cargo processing problems as well as wind tunnel scheduling problems.

  9. Scheduling multicore workload on shared multipurpose clusters

    NASA Astrophysics Data System (ADS)

    Templon, J. A.; Acosta-Silva, C.; Flix Molina, J.; Forti, A. C.; Pérez-Calero Yzquierdo, A.; Starink, R.

    2015-12-01

    With the advent of workloads containing explicit requests for multiple cores in a single grid job, grid sites faced a new set of challenges in workload scheduling. The most common batch schedulers deployed at HEP computing sites do a poor job at multicore scheduling when using only the native capabilities of those schedulers. This paper describes how efficient multicore scheduling was achieved at the sites the authors represent, by implementing dynamically-sized multicore partitions via a minimalistic addition to the Torque/Maui batch system already in use at those sites. The paper further includes example results from use of the system in production, as well as measurements on the dependence of performance (especially the ramp-up in throughput for multicore jobs) on node size and job size.

  10. 14 CFR 399.81 - Unrealistic or deceptive scheduling.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Unrealistic or deceptive scheduling. 399.81... Unrealistic or deceptive scheduling. (a) It is the policy of the Board to consider unrealistic scheduling of... to the advertising of scheduled performance, it is the policy of the Board to regard as an unfair or...

  11. Learning to improve iterative repair scheduling

    NASA Technical Reports Server (NTRS)

    Zweben, Monte; Davis, Eugene

    1992-01-01

    This paper presents a general learning method for dynamically selecting between repair heuristics in an iterative repair scheduling system. The system employs a version of explanation-based learning called Plausible Explanation-Based Learning (PEBL) that uses multiple examples to confirm conjectured explanations. The basic approach is to conjecture contradictions between a heuristic and statistics that measure the quality of the heuristic. When these contradictions are confirmed, a different heuristic is selected. To motivate the utility of this approach we present an empirical evaluation of the performance of a scheduling system with respect to two different repair strategies. We show that the scheduler that learns to choose between the heuristics outperforms the same scheduler with any one of two heuristics alone.

  12. 29 CFR 1952.101 - Developmental schedule.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... (CONTINUED) APPROVED STATE PLANS FOR ENFORCEMENT OF STATE STANDARDS Oregon § 1952.101 Developmental schedule. The Oregon plan is developmental. The schedule of developmental steps as described in the plan is...

  13. 29 CFR 1952.101 - Developmental schedule.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... (CONTINUED) APPROVED STATE PLANS FOR ENFORCEMENT OF STATE STANDARDS Oregon § 1952.101 Developmental schedule. The Oregon plan is developmental. The schedule of developmental steps as described in the plan is...

  14. 33 CFR 401.58 - Pleasure craft scheduling.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Pleasure craft scheduling. 401.58... OF TRANSPORTATION SEAWAY REGULATIONS AND RULES Regulations Seaway Navigation § 401.58 Pleasure craft scheduling. (a) The transit of pleasure craft shall be scheduled by the traffic controller or the officer in...

  15. An Analysis of Research on Block Scheduling

    ERIC Educational Resources Information Center

    Zepeda, Sally J.; Mayers, R. Stewart

    2006-01-01

    In this analysis of 58 empirical studies of high school block scheduling, the authors report findings in and across five groupings. Within groups, data were inconsistent regarding whether teachers' practices changed, but teachers believed that staff development was necessary to teach in a block schedule. Block scheduling appeared to increase…

  16. 7 CFR 275.20 - ME review schedules.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false ME review schedules. 275.20 Section 275.20 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE... Program Performance § 275.20 ME review schedules. (a) Each State agency shall submit its review schedule...

  17. 7 CFR 275.20 - ME review schedules.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 4 2012-01-01 2012-01-01 false ME review schedules. 275.20 Section 275.20 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE... Program Performance § 275.20 ME review schedules. (a) Each State agency shall submit its review schedule...

  18. 7 CFR 275.20 - ME review schedules.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 4 2011-01-01 2011-01-01 false ME review schedules. 275.20 Section 275.20 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE... Program Performance § 275.20 ME review schedules. (a) Each State agency shall submit its review schedule...

  19. 7 CFR 275.20 - ME review schedules.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 4 2013-01-01 2013-01-01 false ME review schedules. 275.20 Section 275.20 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE... Program Performance § 275.20 ME review schedules. (a) Each State agency shall submit its review schedule...

  20. Spike: Artificial intelligence scheduling for Hubble space telescope

    NASA Technical Reports Server (NTRS)

    Johnston, Mark; Miller, Glenn; Sponsler, Jeff; Vick, Shon; Jackson, Robert

    1990-01-01

    Efficient utilization of spacecraft resources is essential, but the accompanying scheduling problems are often computationally intractable and are difficult to approximate because of the presence of numerous interacting constraints. Artificial intelligence techniques were applied to the scheduling of the NASA/ESA Hubble Space Telescope (HST). This presents a particularly challenging problem since a yearlong observing program can contain some tens of thousands of exposures which are subject to a large number of scientific, operational, spacecraft, and environmental constraints. New techniques were developed for machine reasoning about scheduling constraints and goals, especially in cases where uncertainty is an important scheduling consideration and where resolving conflicts among conflicting preferences is essential. These technique were utilized in a set of workstation based scheduling tools (Spike) for HST. Graphical displays of activities, constraints, and schedules are an important feature of the system. High level scheduling strategies using both rule based and neural network approaches were developed. While the specific constraints implemented are those most relevant to HST, the framework developed is far more general and could easily handle other kinds of scheduling problems. The concept and implementation of the Spike system are described along with some experiments in adapting Spike to other spacecraft scheduling domains.

  1. Scheduling time-critical graphics on multiple processors

    NASA Technical Reports Server (NTRS)

    Meyer, Tom W.; Hughes, John F.

    1995-01-01

    This paper describes an algorithm for the scheduling of time-critical rendering and computation tasks on single- and multiple-processor architectures, with minimal pipelining. It was developed to manage scientific visualization scenes consisting of hundreds of objects, each of which can be computed and displayed at thousands of possible resolution levels. The algorithm generates the time-critical schedule using progressive-refinement techniques; it always returns a feasible schedule and, when allowed to run to completion, produces a near-optimal schedule which takes advantage of almost the entire multiple-processor system.

  2. Production scheduling and rescheduling with genetic algorithms.

    PubMed

    Bierwirth, C; Mattfeld, D C

    1999-01-01

    A general model for job shop scheduling is described which applies to static, dynamic and non-deterministic production environments. Next, a Genetic Algorithm is presented which solves the job shop scheduling problem. This algorithm is tested in a dynamic environment under different workload situations. Thereby, a highly efficient decoding procedure is proposed which strongly improves the quality of schedules. Finally, this technique is tested for scheduling and rescheduling in a non-deterministic environment. It is shown by experiment that conventional methods of production control are clearly outperformed at reasonable run-time costs.

  3. Chandra mission scheduling on-orbit experience

    NASA Astrophysics Data System (ADS)

    Bucher, Sabina; Williams, Brent; Pendexter, Misty; Balke, David

    2008-07-01

    Scheduling observatory time to maximize both day-to-day science target integration time and the lifetime of the observatory is a formidable challenge. Furthermore, it is not a static problem. Of course, every schedule brings a new set of observations, but the boundaries of the problem change as well. As spacecraft ages, its capabilities may degrade. As in-flight experience grows, capabilities may expand. As observing programs are completed, the needs and expectations of the science community may evolve. Changes such as these impact the rules by which a mission scheduled. In eight years on orbit, the Chandra X-Ray Observatory Mission Planning process has adapted to meet the challenge of maximizing day-to-day and mission lifetime science return, despite a consistently evolving set of scheduling constraints. The success of the planning team has been achieved, not through the use of complex algorithms and optimization routines, but through processes and home grown tools that help individuals make smart short term and long term Mission Planning decisions. This paper walks through the processes and tools used to plan and produce mission schedules for the Chandra X-Ray Observatory. Nominal planning and scheduling, target of opportunity response, and recovery from on-board autonomous safing actions are all addressed. Evolution of tools and processes, best practices, and lessons learned are highlighted along the way.

  4. Scheduling periodic jobs using imprecise results

    NASA Technical Reports Server (NTRS)

    Chung, Jen-Yao; Liu, Jane W. S.; Lin, Kwei-Jay

    1987-01-01

    One approach to avoid timing faults in hard, real-time systems is to make available intermediate, imprecise results produced by real-time processes. When a result of the desired quality cannot be produced in time, an imprecise result of acceptable quality produced before the deadline can be used. The problem of scheduling periodic jobs to meet deadlines on a system that provides the necessary programming language primitives and run-time support for processes to return imprecise results is discussed. Since the scheduler may choose to terminate a task before it is completed, causing it to produce an acceptable but imprecise result, the amount of processor time assigned to any task in a valid schedule can be less than the amount of time required to complete the task. A meaningful formulation of the scheduling problem must take into account the overall quality of the results. Depending on the different types of undesirable effects caused by errors, jobs are classified as type N or type C. For type N jobs, the effects of errors in results produced in different periods are not cumulative. A reasonable performance measure is the average error over all jobs. Three heuristic algorithms that lead to feasible schedules with small average errors are described. For type C jobs, the undesirable effects of errors produced in different periods are cumulative. Schedulability criteria of type C jobs are discussed.

  5. 9 CFR 307.4 - Schedule of operations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... inspectors shall not, except as provided herein, occur prior to 4 hours after the beginning of scheduled... efficient and effective use of inspection personnel. The work schedule must specify daily clock hours of... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Schedule of operations. 307.4 Section...

  6. To Block-Schedule or Not?

    ERIC Educational Resources Information Center

    Mowen, Gregg G.; Mowen, Carol

    2004-01-01

    In this article, the authors discuss the advantages of block scheduling and how it can be an effective educational tool when faced with educational challenges. Block schedules can ease the transition from the homelike atmosphere of the elementary school to the departmentalized environment of the high school by reducing the need for constant class…

  7. Evaluation of scheduling techniques for payload activity planning

    NASA Technical Reports Server (NTRS)

    Bullington, Stanley F.

    1991-01-01

    Two tasks related to payload activity planning and scheduling were performed. The first task involved making a comparison of space mission activity scheduling problems with production scheduling problems. The second task consisted of a statistical analysis of the output of runs of the Experiment Scheduling Program (ESP). Details of the work which was performed on these two tasks are presented.

  8. 48 CFR 245.606 - Inventory schedules.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Inventory schedules. 245.606 Section 245.606 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM... Contractor Inventory 245.606 Inventory schedules. ...

  9. Immunization Schedules for Preteens and Teens

    MedlinePlus

    ... Immunization Schedule for Preteens and Teens (7 through 18 Years) Recommend on Facebook Tweet Share Compartir On ... a Catch-Up or Accelerated Schedule Birth through 18 Years In three easy steps, you can use ...

  10. Optimal radiotherapy dose schedules under parametric uncertainty

    NASA Astrophysics Data System (ADS)

    Badri, Hamidreza; Watanabe, Yoichi; Leder, Kevin

    2016-01-01

    We consider the effects of parameter uncertainty on the optimal radiation schedule in the context of the linear-quadratic model. Our interest arises from the observation that if inter-patient variability in normal and tumor tissue radiosensitivity or sparing factor of the organs-at-risk (OAR) are not accounted for during radiation scheduling, the performance of the therapy may be strongly degraded or the OAR may receive a substantially larger dose than the allowable threshold. This paper proposes a stochastic radiation scheduling concept to incorporate inter-patient variability into the scheduling optimization problem. Our method is based on a probabilistic approach, where the model parameters are given by a set of random variables. Our probabilistic formulation ensures that our constraints are satisfied with a given probability, and that our objective function achieves a desired level with a stated probability. We used a variable transformation to reduce the resulting optimization problem to two dimensions. We showed that the optimal solution lies on the boundary of the feasible region and we implemented a branch and bound algorithm to find the global optimal solution. We demonstrated how the configuration of optimal schedules in the presence of uncertainty compares to optimal schedules in the absence of uncertainty (conventional schedule). We observed that in order to protect against the possibility of the model parameters falling into a region where the conventional schedule is no longer feasible, it is required to avoid extremal solutions, i.e. a single large dose or very large total dose delivered over a long period. Finally, we performed numerical experiments in the setting of head and neck tumors including several normal tissues to reveal the effect of parameter uncertainty on optimal schedules and to evaluate the sensitivity of the solutions to the choice of key model parameters.

  11. Stochastic Modeling of Airlines' Scheduled Services Revenue

    NASA Technical Reports Server (NTRS)

    Hamed, M. M.

    1999-01-01

    Airlines' revenue generated from scheduled services account for the major share in the total revenue. As such, predicting airlines' total scheduled services revenue is of great importance both to the governments (in case of national airlines) and private airlines. This importance stems from the need to formulate future airline strategic management policies, determine government subsidy levels, and formulate governmental air transportation policies. The prediction of the airlines' total scheduled services revenue is dealt with in this paper. Four key components of airline's scheduled services are considered. These include revenues generated from passenger, cargo, mail, and excess baggage. By addressing the revenue generated from each schedule service separately, air transportation planners and designers arc able to enhance their ability to formulate specific strategies for each component. Estimation results clearly indicate that the four stochastic processes (scheduled services components) are represented by different Box-Jenkins ARIMA models. The results demonstrate the appropriateness of the developed models and their ability to provide air transportation planners with future information vital to the planning and design processes.

  12. Stochastic Modeling of Airlines' Scheduled Services Revenue

    NASA Technical Reports Server (NTRS)

    Hamed, M. M.

    1999-01-01

    Airlines' revenue generated from scheduled services account for the major share in the total revenue. As such, predicting airlines' total scheduled services revenue is of great importance both to the governments (in case of national airlines) and private airlines. This importance stems from the need to formulate future airline strategic management policies, determine government subsidy levels, and formulate governmental air transportation policies. The prediction of the airlines' total scheduled services revenue is dealt with in this paper. Four key components of airline's scheduled services are considered. These include revenues generated from passenger, cargo, mail, and excess baggage. By addressing the revenue generated from each schedule service separately, air transportation planners and designers are able to enhance their ability to formulate specific strategies for each component. Estimation results clearly indicate that the four stochastic processes (scheduled services components) are represented by different Box-Jenkins ARIMA models. The results demonstrate the appropriateness of the developed models and their ability to provide air transportation planners with future information vital to the planning and design processes.

  13. Achieving reutilization of scheduling software through abstraction and generalization

    NASA Technical Reports Server (NTRS)

    Wilkinson, George J.; Monteleone, Richard A.; Weinstein, Stuart M.; Mohler, Michael G.; Zoch, David R.; Tong, G. Michael

    1995-01-01

    Reutilization of software is a difficult goal to achieve particularly in complex environments that require advanced software systems. The Request-Oriented Scheduling Engine (ROSE) was developed to create a reusable scheduling system for the diverse scheduling needs of the National Aeronautics and Space Administration (NASA). ROSE is a data-driven scheduler that accepts inputs such as user activities, available resources, timing contraints, and user-defined events, and then produces a conflict-free schedule. To support reutilization, ROSE is designed to be flexible, extensible, and portable. With these design features, applying ROSE to a new scheduling application does not require changing the core scheduling engine, even if the new application requires significantly larger or smaller data sets, customized scheduling algorithms, or software portability. This paper includes a ROSE scheduling system description emphasizing its general-purpose features, reutilization techniques, and tasks for which ROSE reuse provided a low-risk solution with significant cost savings and reduced software development time.

  14. Slide Rule For Calculating Curing Schedules

    NASA Technical Reports Server (NTRS)

    Heater, Don

    1995-01-01

    Special-purpose slide rule devised for calculating schedules for storing and curing adhesives, sealants, and other materials characterized by known curing times and shelf lives. Prevents mistakes commonly made in determining storage and curing schedules.

  15. Flexible Work Schedules. ERIC Digest.

    ERIC Educational Resources Information Center

    Kerka, Sandra

    Flexible work schedules are one response to changes in the composition of the work force, new life-styles, and changes in work attitudes. Types of alternative work schedules are part-time and temporary employment, job sharing, and flextime. Part-time workers are a diverse group--women, the very young, and older near-retirees. Although part-time…

  16. Toward an Autonomous Telescope Network: the TBT Scheduler

    NASA Astrophysics Data System (ADS)

    Racero, E.; Ibarra, A.; Ocaña, F.; de Lis, S. B.; Ponz, J. D.; Castillo, M.; Sánchez-Portal, M.

    2015-09-01

    Within the ESA SSA program, it is foreseen to deploy several robotic telescopes to provide surveillance and tracking services for hazardous objects. The TBT project will procure a validation platform for an autonomous optical observing system in a realistic scenario, consisting of two telescopes located in Spain and Australia, to collect representative test data for precursor SSA services. In this context, the planning and scheduling of the night consists of two software modules, the TBT Scheduler, that will allow the manual and autonomous planning of the night, and the control of the real-time response of the system, done by the RTS2 internal scheduler. The TBT Scheduler allocates tasks for both telescopes without human intervention. Every night it takes all the inputs needed and prepares the schedule following some predefined rules. The main purpose of the scheduler is the distribution of the time for follow-up of recently discovered targets and surveys. The TBT Scheduler considers the overall performance of the system, and combine follow-up with a priori survey strategies for both kind of objects. The strategy is defined according to the expected combined performance for both systems the upcoming night (weather, sky brightness, object accessibility and priority). Therefore, TBT Scheduler defines the global approach for the network and relies on the RTS2 internal scheduler for the final detailed distribution of tasks at each sensor.

  17. SPIKE: AI scheduling techniques for Hubble Space Telescope

    NASA Astrophysics Data System (ADS)

    Johnston, Mark D.

    1991-09-01

    AI (Artificial Intelligence) scheduling techniques for HST are presented in the form of the viewgraphs. The following subject areas are covered: domain; HST constraint timescales; HTS scheduling; SPIKE overview; SPIKE architecture; constraint representation and reasoning; use of suitability functions by scheduling agent; SPIKE screen example; advantages of suitability function framework; limiting search and constraint propagation; scheduling search; stochastic search; repair methods; implementation; and status.

  18. Observation Scheduling System

    NASA Technical Reports Server (NTRS)

    Chien, Steve A.; Tran, Daniel Q.; Rabideau, Gregg R.; Schaffer, Steven R.

    2011-01-01

    Software has been designed to schedule remote sensing with the Earth Observing One spacecraft. The software attempts to satisfy as many observation requests as possible considering each against spacecraft operation constraints such as data volume, thermal, pointing maneuvers, and others. More complex constraints such as temperature are approximated to enable efficient reasoning while keeping the spacecraft within safe limits. Other constraints are checked using an external software library. For example, an attitude control library is used to determine the feasibility of maneuvering between pairs of observations. This innovation can deal with a wide range of spacecraft constraints and solve large scale scheduling problems like hundreds of observations and thousands of combinations of observation sequences.

  19. Departure Queue Prediction for Strategic and Tactical Surface Scheduler Integration

    NASA Technical Reports Server (NTRS)

    Zelinski, Shannon; Windhorst, Robert

    2016-01-01

    A departure metering concept to be demonstrated at Charlotte Douglas International Airport (CLT) will integrate strategic and tactical surface scheduling components to enable the respective collaborative decision making and improved efficiency benefits these two methods of scheduling provide. This study analyzes the effect of tactical scheduling on strategic scheduler predictability. Strategic queue predictions and target gate pushback times to achieve a desired queue length are compared between fast time simulations of CLT surface operations with and without tactical scheduling. The use of variable departure rates as a strategic scheduler input was shown to substantially improve queue predictions over static departure rates. With target queue length calibration, the strategic scheduler can be tuned to produce average delays within one minute of the tactical scheduler. However, root mean square differences between strategic and tactical delays were between 12 and 15 minutes due to the different methods the strategic and tactical schedulers use to predict takeoff times and generate gate pushback clearances. This demonstrates how difficult it is for the strategic scheduler to predict tactical scheduler assigned gate delays on an individual flight basis as the tactical scheduler adjusts departure sequence to accommodate arrival interactions. Strategic/tactical scheduler compatibility may be improved by providing more arrival information to the strategic scheduler and stabilizing tactical scheduler changes to runway sequence in response to arrivals.

  20. Mission Operations Planning and Scheduling System (MOPSS)

    NASA Technical Reports Server (NTRS)

    Wood, Terri; Hempel, Paul

    2011-01-01

    MOPSS is a generic framework that can be configured on the fly to support a wide range of planning and scheduling applications. It is currently used to support seven missions at Goddard Space Flight Center (GSFC) in roles that include science planning, mission planning, and real-time control. Prior to MOPSS, each spacecraft project built its own planning and scheduling capability to plan satellite activities and communications and to create the commands to be uplinked to the spacecraft. This approach required creating a data repository for storing planning and scheduling information, building user interfaces to display data, generating needed scheduling algorithms, and implementing customized external interfaces. Complex scheduling problems that involved reacting to multiple variable situations were analyzed manually. Operators then used the results to add commands to the schedule. Each architecture was unique to specific satellite requirements. MOPSS is an expert system that automates mission operations and frees the flight operations team to concentrate on critical activities. It is easily reconfigured by the flight operations team as the mission evolves. The heart of the system is a custom object-oriented data layer mapped onto an Oracle relational database. The combination of these two technologies allows a user or system engineer to capture any type of scheduling or planning data in the system's generic data storage via a GUI.

  1. Alternative work schedules for female pharmacists.

    PubMed

    Mason, N A; Perry, W R; Ryan, M L

    1991-01-01

    The impact of the increased proportion of women in pharmacy is discussed, and two leadership positions for which part-time work schedules were implemented are described. Issues associated with the increased representation of women include pharmacist shortages, loss of future leaders, decreased staff productivity related to inadequate day-care services, and a reduced earning potential of pharmacists. Many of these problems can be addressed by altering benefit packages and work schedules to enable employees to raise children while continuing to work. Specific strategies include legislation, day-care programs, flex time and flex scheduling, telecommuting, and the creation of alternative work schedules or permanent part-time positions. At the University of Michigan, a part-time position that combines faculty and clinical responsibilities has been in place since 1988. At The Washington Hospital Center, one of the three assistant director of pharmacy positions is part-time. The women in both positions have met or exceeded job performance requirements while raising a family. Issues raised by the increasing number of female pharmacists must be addressed by the profession. Part-time work schedules are one strategy for enabling female pharmacists to meet both their family and career responsibilities.

  2. Firefighter Shift Schedules Affect Sleep Quality.

    PubMed

    Billings, Joel; Focht, Will

    2016-03-01

    The aim of this study was to investigate the prevalence and severity of firefighter sleep quality across department shift schedules. Sleep quality was assessed using a Pittsburgh Sleep Quality Index in a sample of 109 male career firefighters from six fire departments in three Southwestern US states. The three shift schedules studied were 24on/48off, 48on/96off, and Kelly. Seventy-three percent of firefighters report poor sleep quality. The 24on/48off shift schedule is associated with the best sleep quality and Kelly is associated with the worst sleep quality. Firefighters working second jobs report significantly poorer sleep quality than those who do not. Shift schedules that disrupt normal circadian rhythms more result in poorer sleep quality, which can lead to less effective emergency response and increased risk to firefighter health and safety.

  3. Scheduling job shop - A case study

    NASA Astrophysics Data System (ADS)

    Abas, M.; Abbas, A.; Khan, W. A.

    2016-08-01

    The scheduling in job shop is important for efficient utilization of machines in the manufacturing industry. There are number of algorithms available for scheduling of jobs which depend on machines tools, indirect consumables and jobs which are to be processed. In this paper a case study is presented for scheduling of jobs when parts are treated on available machines. Through time and motion study setup time and operation time are measured as total processing time for variety of products having different manufacturing processes. Based on due dates different level of priority are assigned to the jobs and the jobs are scheduled on the basis of priority. In view of the measured processing time, the times for processing of some new jobs are estimated and for efficient utilization of the machines available an algorithm is proposed and validated.

  4. Evaluation of fixed momentary dro schedules under signaled and unsignaled arrangements.

    PubMed

    Hammond, Jennifer L; Iwata, Brian A; Fritz, Jennifer N; Dempsey, Carrie M

    2011-01-01

    Fixed momentary schedules of differential reinforcement of other behavior (FM DRO) generally have been ineffective as treatment for problem behavior. Because most early research on FM DRO included presentation of a signal at the end of the DRO interval, it is unclear whether the limited effects of FM DRO were due to (a) the momentary response requirement of the schedule per se or (b) discrimination of the contingency made more salient by the signal. To separate these two potential influences, we compared the effects of signaled versus unsignaled FM DRO with 4 individuals with developmental disabilities whose problem behavior was maintained by social-positive reinforcement. During signaled FM DRO, the experimenter presented a visual stimulus 3 s prior to the end of the DRO interval and delivered reinforcement contingent on the absence of problem behavior at the second the interval elapsed. Unsignaled DRO was identical except that interval termination was not signaled. Results indicated that signaled FM DRO was effective in decreasing 2 subjects' problem behavior, whereas an unsignaled schedule was required for the remaining 2 subjects. These results suggest that the response requirement per se of FM DRO may not be problematic if it is not easily discriminated.

  5. Human-Machine Collaborative Optimization via Apprenticeship Scheduling

    DTIC Science & Technology

    2016-09-09

    prenticeship Scheduling (COVAS), which performs ma- chine learning using human expert demonstration, in conjunction with optimization, to automatically and ef...ficiently produce optimal solutions to challenging real- world scheduling problems. COVAS first learns a policy from human scheduling demonstration via...apprentice- ship learning , then uses this initial solution to provide a tight bound on the value of the optimal solution, thereby substantially

  6. Proposed Schedule for Fenton Hill Experiments

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Albright, James N.; Brown, Donald W.

    To help in planning Fenton Hill experimental operations in concert with preparations for the Long-Term Flow Test (LTFT) next summer, the following schedule is proposed. This schedule fits some of the realities of the next few months, including the Laboratory closure during the Holidays, the seismic monitoring tests in Roswell, and the difficulties of operating during the winter months. Whenever possible, cyclic pumping operations during the colder months will be scheduled so that the pump will be on during the late evening and early morning hours to prevent freezeup.

  7. Shiftwork Scheduling for the 1990s.

    ERIC Educational Resources Information Center

    Coleman, Richard M.

    1989-01-01

    The author discusses the problems of scheduling shift work, touching on such topics as employee desires, health requirements, and business needs. He presents a method for developing shift schedules that addresses these three areas. Implementation hints are also provided. (CH)

  8. Natural conception rates in couples with unexplained or mild male subfertility scheduled for fertility treatment: a secondary analysis of a randomized controlled trial.

    PubMed

    van Eekelen, R; Tjon-Kon-Fat, R I; Bossuyt, P M M; van Geloven, N; Eijkemans, M J C; Bensdorp, A J; van der Veen, F; Mol, B W; van Wely, M

    2018-05-01

    What is the natural conception rate over the course of 12 months in couples with unexplained or mild male subfertility who are scheduled for fertility treatment and have a predicted unfavourable prognosis for natural conception? The natural conception rate over the course of 12 months in couples who were allocated to treatment was estimated to be 24.5% (95% CI: 20-29%). After starting treatment, couples often perceive unsuccessful cycles as evidence of definitive failure even though they are still able to conceive naturally in between and after treatment. The magnitude of the natural conception rate for couples who chose to commence treatment is unknown, as is whether the calculated prognosis before commencing treatment is still applicable. We performed a secondary analysis of a randomized controlled trial including couples with unexplained or mild male subfertility and an unfavourable prognosis for natural conception. Couples were allocated to either three cycles IVF with single embryo transfer (SET), six cycles of IVF in a modified natural cycle (MNC) or six cycles of IUI with controlled ovarian hyperstimulation (IUI-COH). The detailed data collection in this trial allowed us to study the conception rates in periods that couples were not receiving treatment. We split the dataset into periods during which couples were treated and periods during which they were not treated. Couples could conceive naturally in the periods before, in between and after treatment cycles. The outcome was ongoing pregnancy, thus natural conception rate refers to natural conception leading to ongoing pregnancy. We performed a Cox proportional hazards analysis with female age, duration of subfertility and a time-varying covariate with four categories: IVF-SET, IVF-MNC, IUI-COH and no treatment. We used this Cox model to estimate the natural conception rate over 12 months of no treatment. Out of 602 included couples, there were 342 ongoing pregnancies, of which 77 (23%) resulted from

  9. 20 CFR 10.413 - If a person dies while receiving a schedule award, to whom is the balance of the schedule award...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false If a person dies while receiving a schedule award, to whom is the balance of the schedule award payable? 10.413 Section 10.413 Employees' Benefits... balance of the schedule award payable? The circumstances under which the balance of a schedule award may...

  10. 20 CFR 10.413 - If a person dies while receiving a schedule award, to whom is the balance of the schedule award...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 1 2011-04-01 2011-04-01 false If a person dies while receiving a schedule award, to whom is the balance of the schedule award payable? 10.413 Section 10.413 Employees' Benefits... balance of the schedule award payable? The circumstances under which the balance of a schedule award may...

  11. XOPPS - OEL PROJECT PLANNER/SCHEDULER TOOL

    NASA Technical Reports Server (NTRS)

    Mulnix, C. L.

    1994-01-01

    XOPPS is a window-based graphics tool for scheduling and project planning that provides easy and fast on-screen WYSIWYG editing capabilities. It has a canvas area which displays the full image of the schedule being edited. The canvas contains a header area for text and a schedule area for plotting graphic representations of milestone objects in a flexible timeline. XOPPS is object-oriented, but it is unique in its capability for creating objects that have date attributes. Each object on the screen can be treated as a unit for moving, editing, etc. There is a mouse interface for simple control of pointer location. The user can position objects to pixel resolution, but objects with an associated date are positioned automatically in their correct timeline position in the schedule area. The schedule area has horizontal lines across the page with capabilities for multiple pages and for editing the number of lines per page and the line grid. The text on a line can be edited and a line can be moved with all objects on the line moving with it. The timeline display can be edited to plot any time period in a variety of formats from Fiscal year to Calendar Year and days to years. Text objects and image objects (rasterfiles and icons) can be created for placement anywhere on the page. Milestone event objects with a single associated date (and optional text and milestone symbol) and activity objects with start and end dates (and an optional completion date) have unique editing panels for entering data. A representation for schedule slips is also provided with the capability to automatically convert a milestone event to a slip. A milestone schedule on another computer can be saved to an ASCII file to be read by XOPPS. The program can print a schedule to a PostScript file. Dependencies between objects can also be displayed on the chart through the use of precedence lines. This program is not intended to replace a commercial scheduling/project management program. Because XOPPS has

  12. Payload crew training scheduler (PACTS) user's manual

    NASA Technical Reports Server (NTRS)

    Shipman, D. L.

    1980-01-01

    The operation of the payload specialist training scheduler (PACTS) is discussed in this user's manual which is used to schedule payload specialists for mission training on the Spacelab experiments. The PACTS program is a fully automated interactive, computerized scheduling program equipped with tutorial displays. The tutorial displays are sufficiently detailed for use by a program analyst having no computer experience. The PACTS program is designed to operate on the UNIVAC 1108 computer system, and has the capability to load output into a PDP 11/45 Interactive Graphics Display System for printing schedules. The program has the capacity to handle up to three overlapping Spacelab missions.

  13. A feasibility study: Selection of a personalized radiotherapy fractionation schedule using spatiotemporal optimization

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kim, Minsun, E-mail: mk688@uw.edu; Stewart, Robert D.; Phillips, Mark H.

    2015-11-15

    proliferating tumors with T{sub d} less than 10 days, there was no significant increase in tumor BED but the treatment course could be shortened without a loss in tumor BED. The improvement in the tumor mean BED was more pronounced with smaller tumors (p-value = 0.08). Conclusions: Spatiotemporal optimization of patient plans has the potential to significantly improve local tumor control (larger BED/EUD) of patients with a favorable geometry, such as smaller tumors with larger distances between the tumor target and nearby OAR. In patients with a less favorable geometry and for fast growing tumors, plans optimized using spatiotemporal optimization and conventional (spatial-only) optimization are equivalent (negligible differences in tumor BED/EUD). However, spatiotemporal optimization yields shorter treatment courses than conventional spatial-only optimization. Personalized, spatiotemporal optimization of treatment schedules can increase patient convenience and help with the efficient allocation of clinical resources. Spatiotemporal optimization can also help identify a subset of patients that might benefit from nonconventional (large dose per fraction) treatments that are ineligible for the current practice of stereotactic body radiation therapy.« less

  14. 40 CFR 52.1524 - Compliance schedules.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 4 2014-07-01 2014-07-01 false Compliance schedules. 52.1524 Section 52.1524 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS (CONTINUED) New Hampshire § 52.1524 Compliance schedules...

  15. 40 CFR 52.1524 - Compliance schedules.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 4 2012-07-01 2012-07-01 false Compliance schedules. 52.1524 Section 52.1524 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS (CONTINUED) New Hampshire § 52.1524 Compliance schedules...

  16. 40 CFR 52.1524 - Compliance schedules.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 4 2011-07-01 2011-07-01 false Compliance schedules. 52.1524 Section 52.1524 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS (CONTINUED) New Hampshire § 52.1524 Compliance schedules...

  17. 40 CFR 52.1524 - Compliance schedules.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 4 2013-07-01 2013-07-01 false Compliance schedules. 52.1524 Section 52.1524 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS (CONTINUED) New Hampshire § 52.1524 Compliance schedules...

  18. A computerized resolution of scheduling conflicts.

    PubMed

    Bolinger, R E; McFarlane, M J

    1989-01-01

    Residency training programs in Internal Medicine require resident attendance in a continuity clinic. This inevitably engenders conflicts between scheduling in the ambulatory clinic and the required teaching activities of the in-patient services. Some of the conflicts can be resolved by allowing the in-patient service directors to indicate preferred plans for their residents to attend in the continuity clinic. With this plan, scheduling becomes quite complicated. A computer program is presented with coordinates these service requests with ambulatory clinic scheduling. As a result, a given resident may have his/her clinic day changed on different rotations. The program automatically arbitrates conflicts and publishes the attendance dates for the entire academic year. This information is supplied to the appointment desk so that patients can be scheduled accordingly. This system has resulted in a 74% continuity rate and improved satisfaction by both residents and staff.

  19. Efficient genetic algorithms using discretization scheduling.

    PubMed

    McLay, Laura A; Goldberg, David E

    2005-01-01

    In many applications of genetic algorithms, there is a tradeoff between speed and accuracy in fitness evaluations when evaluations use numerical methods with varying discretization. In these types of applications, the cost and accuracy vary from discretization errors when implicit or explicit quadrature is used to estimate the function evaluations. This paper examines discretization scheduling, or how to vary the discretization within the genetic algorithm in order to use the least amount of computation time for a solution of a desired quality. The effectiveness of discretization scheduling can be determined by comparing its computation time to the computation time of a GA using a constant discretization. There are three ingredients for the discretization scheduling: population sizing, estimated time for each function evaluation and predicted convergence time analysis. Idealized one- and two-dimensional experiments and an inverse groundwater application illustrate the computational savings to be achieved from using discretization scheduling.

  20. Knowledge-based scheduling of arrival aircraft

    NASA Technical Reports Server (NTRS)

    Krzeczowski, K.; Davis, T.; Erzberger, H.; Lev-Ram, I.; Bergh, C.

    1995-01-01

    A knowledge-based method for scheduling arrival aircraft in the terminal area has been implemented and tested in real-time simulation. The scheduling system automatically sequences, assigns landing times, and assigns runways to arrival aircraft by utilizing continuous updates of aircraft radar data and controller inputs. The scheduling algorithms is driven by a knowledge base which was obtained in over two thousand hours of controller-in-the-loop real-time simulation. The knowledge base contains a series of hierarchical 'rules' and decision logic that examines both performance criteria, such as delay reduction, as well as workload reduction criteria, such as conflict avoidance. The objective of the algorithms is to devise an efficient plan to land the aircraft in a manner acceptable to the air traffic controllers. This paper will describe the scheduling algorithms, give examples of their use, and present data regarding their potential benefits to the air traffic system.

  1. Autonomous mission planning and scheduling: Innovative, integrated, responsive

    NASA Technical Reports Server (NTRS)

    Sary, Charisse; Liu, Simon; Hull, Larry; Davis, Randy

    1994-01-01

    Autonomous mission scheduling, a new concept for NASA ground data systems, is a decentralized and distributed approach to scientific spacecraft planning, scheduling, and command management. Systems and services are provided that enable investigators to operate their own instruments. In autonomous mission scheduling, separate nodes exist for each instrument and one or more operations nodes exist for the spacecraft. Each node is responsible for its own operations which include planning, scheduling, and commanding; and for resolving conflicts with other nodes. One or more database servers accessible to all nodes enable each to share mission and science planning, scheduling, and commanding information. The architecture for autonomous mission scheduling is based upon a realistic mix of state-of-the-art and emerging technology and services, e.g., high performance individual workstations, high speed communications, client-server computing, and relational databases. The concept is particularly suited to the smaller, less complex missions of the future.

  2. Research on schedulers for astronomical observatories

    NASA Astrophysics Data System (ADS)

    Colome, Josep; Colomer, Pau; Guàrdia, Josep; Ribas, Ignasi; Campreciós, Jordi; Coiffard, Thierry; Gesa, Lluis; Martínez, Francesc; Rodler, Florian

    2012-09-01

    The main task of a scheduler applied to astronomical observatories is the time optimization of the facility and the maximization of the scientific return. Scheduling of astronomical observations is an example of the classical task allocation problem known as the job-shop problem (JSP), where N ideal tasks are assigned to M identical resources, while minimizing the total execution time. A problem of higher complexity, called the Flexible-JSP (FJSP), arises when the tasks can be executed by different resources, i.e. by different telescopes, and it focuses on determining a routing policy (i.e., which machine to assign for each operation) other than the traditional scheduling decisions (i.e., to determine the starting time of each operation). In most cases there is no single best approach to solve the planning system and, therefore, various mathematical algorithms (Genetic Algorithms, Ant Colony Optimization algorithms, Multi-Objective Evolutionary algorithms, etc.) are usually considered to adapt the application to the system configuration and task execution constraints. The scheduling time-cycle is also an important ingredient to determine the best approach. A shortterm scheduler, for instance, has to find a good solution with the minimum computation time, providing the system with the capability to adapt the selected task to varying execution constraints (i.e., environment conditions). We present in this contribution an analysis of the task allocation problem and the solutions currently in use at different astronomical facilities. We also describe the schedulers for three different projects (CTA, CARMENES and TJO) where the conclusions of this analysis are applied to develop a suitable routine.

  3. A phase I and pharmacologic trial of two schedules of the proteasome inhibitor, PS-341 (bortezomib, velcade), in patients with advanced cancer.

    PubMed

    Dy, Grace K; Thomas, James P; Wilding, George; Bruzek, Laura; Mandrekar, Sumithra; Erlichman, Charles; Alberti, Dona; Binger, Kim; Pitot, Henry C; Alberts, Steven R; Hanson, Lorelei J; Marnocha, Rebecca; Tutsch, Kendra; Kaufmann, Scott H; Adjei, Alex A

    2005-05-01

    To define the toxicities, pharmacodynamics, and clinical activity of the proteasome inhibitor, PS-341 (bortezomib), in patients with advanced malignancies. Twenty-eight patients (14 male and 14 female) received PS-341 twice weekly for 4 of 6 weeks (schedule I). Because toxicity necessitated dose omissions on this schedule, 16 additional patients (12 male and 4 female) received PS-341 twice weekly for 2 of every 3 weeks (schedule II). A total of 73 courses of treatment was given (median, 2; range, 1-4). Inhibition of 20S proteasome activity in peripheral blood mononuclear cells (PBMC) and accumulation of proteasome-targeted polypeptides in tumor tissue were evaluated as pharmacodynamic markers of PS-341 activity. The most common toxicity was thrombocytopenia, which was dose limiting at 1.7 mg/m2 (schedule I) and 1.6 mg/m2 (schedule II), respectively. Sensory neuropathy was dose-limiting in a patient in schedule I. Grade > or =3 toxicities for schedule I were constipation, fatigue, myalgia, and sensory neuropathy. Grade > or =3 toxicities for schedule II were dehydration resulting from diarrhea, nausea and vomiting, fatigue, hypoglycemia, and hypotension. The maximum tolerated dose was 1.5 mg/m2 for both schedules. Reversible dose-dependent decreases in 20S proteasome activity in PBMCs were observed, with 36% inhibition at 0.5 mg/m2, 52% at 0.9 mg/m2, and 75% at 1.25 mg/m2. Accumulation of proteasome-targeted polypeptides was detected in tumor samples after treatment with PS-341. A patient with multiple myeloma had a partial response. PS-341 given 1.5 mg/m2 twice weekly for 2 of every 3 weeks is well tolerated and should be further studied.

  4. Integrated planning and scheduling for Earth science data processing

    NASA Technical Reports Server (NTRS)

    Boddy, Mark; White, Jim; Goldman, Robert; Short, Nick, Jr.

    1995-01-01

    Several current NASA programs such as the EOSDIS Core System (ECS) have data processing and data management requirements that call for an integrated planning and scheduling capability. In this paper, we describe the experience of applying advanced scheduling technology operationally, in terms of what was accomplished, lessons learned, and what remains to be done in order to achieve similar successes in ECS and other programs. We discuss the importance and benefits of advanced scheduling tools, and our progress toward realizing them, through examples and illustrations based on ECS requirements. The first part of the paper focuses on the Data Archive and Distribution (DADS) V0 Scheduler. We then discuss system integration issues ranging from communication with the scheduler to the monitoring of system events and re-scheduling in response to them. The challenge of adapting the scheduler to domain-specific features and scheduling policies is also considered. Extrapolation to the ECS domain raises issues of integrating scheduling with a product-generation planner (such as PlaSTiC), and implementing conditional planning in an operational system. We conclude by briefly noting ongoing technology development and deployment projects being undertaken by HTC and the ISTB.

  5. Diverse task scheduling for individualized requirements in cloud manufacturing

    NASA Astrophysics Data System (ADS)

    Zhou, Longfei; Zhang, Lin; Zhao, Chun; Laili, Yuanjun; Xu, Lida

    2018-03-01

    Cloud manufacturing (CMfg) has emerged as a new manufacturing paradigm that provides ubiquitous, on-demand manufacturing services to customers through network and CMfg platforms. In CMfg system, task scheduling as an important means of finding suitable services for specific manufacturing tasks plays a key role in enhancing the system performance. Customers' requirements in CMfg are highly individualized, which leads to diverse manufacturing tasks in terms of execution flows and users' preferences. We focus on diverse manufacturing tasks and aim to address their scheduling issue in CMfg. First of all, a mathematical model of task scheduling is built based on analysis of the scheduling process in CMfg. To solve this scheduling problem, we propose a scheduling method aiming for diverse tasks, which enables each service demander to obtain desired manufacturing services. The candidate service sets are generated according to subtask directed graphs. An improved genetic algorithm is applied to searching for optimal task scheduling solutions. The effectiveness of the scheduling method proposed is verified by a case study with individualized customers' requirements. The results indicate that the proposed task scheduling method is able to achieve better performance than some usual algorithms such as simulated annealing and pattern search.

  6. Schedules of controlled substances: temporary placement of three synthetic cannabinoids into Schedule I. Final order.

    PubMed

    2013-05-16

    The Deputy Administrator of the Drug Enforcement Administration (DEA) is issuing this final order to temporarily schedule three synthetic cannabinoids under the Controlled Substances Act (CSA) pursuant to the temporary scheduling provisions of 21 U.S.C. 811(h). The substances are (1-pentyl-1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone (UR-144), [1-(5-fluoro-pentyl)-1H-indol-3-yl](2,2,3,3-tetramethylcyclopropyl)methanone (5-fluoro-UR-144, XLR11) and N-(1-adamantyl)-1-pentyl-1H-indazole-3-carboxamide (APINACA, AKB48). This action is based on a finding by the Deputy Administrator that the placement of these synthetic cannabinoids and their salts, isomers and salts of isomers into Schedule I of the CSA is necessary to avoid an imminent hazard to the public safety. As a result of this order, the full effect of the CSA and the Controlled Substances Import and Export Act (CSIEA) and their implementing regulations including criminal, civil and administrative penalties, sanctions and regulatory controls of Schedule I substances will be imposed on the manufacture, distribution, possession, importation, and exportation of these synthetic cannabinoids.

  7. Multi-Objective Scheduling for the Cluster II Constellation

    NASA Technical Reports Server (NTRS)

    Johnston, Mark D.; Giuliano, Mark

    2011-01-01

    This paper describes the application of the MUSE multiobjecctive scheduling framework to the Cluster II WBD scheduling domain. Cluster II is an ESA four-spacecraft constellation designed to study the plasma environment of the Earth and it's magnetosphere. One of the instruments on each of the four spacecraft is the Wide Band Data (WBD) plasma wave experiment. We have applied the MUSE evolutionary algorithm to the scheduling problem represented by this instrument, and the result has been adopted and utilized by the WBD schedulers for nearly a year. This paper describes the WBD scheduling problem, its representation in MUSE, and some of the visualization elements that provide insight into objective value tradeoffs.

  8. 23 CFR 140.604 - Reimbursable schedule.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 23 Highways 1 2013-04-01 2013-04-01 false Reimbursable schedule. 140.604 Section 140.604 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PAYMENT PROCEDURES REIMBURSEMENT Reimbursement for Bond Issue Projects § 140.604 Reimbursable schedule. Projects to be financed from other than...

  9. 23 CFR 140.604 - Reimbursable schedule.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 23 Highways 1 2010-04-01 2010-04-01 false Reimbursable schedule. 140.604 Section 140.604 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PAYMENT PROCEDURES REIMBURSEMENT Reimbursement for Bond Issue Projects § 140.604 Reimbursable schedule. Projects to be financed from other than...

  10. 23 CFR 140.604 - Reimbursable schedule.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 23 Highways 1 2014-04-01 2014-04-01 false Reimbursable schedule. 140.604 Section 140.604 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PAYMENT PROCEDURES REIMBURSEMENT Reimbursement for Bond Issue Projects § 140.604 Reimbursable schedule. Projects to be financed from other than...

  11. 23 CFR 140.604 - Reimbursable schedule.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 23 Highways 1 2011-04-01 2011-04-01 false Reimbursable schedule. 140.604 Section 140.604 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PAYMENT PROCEDURES REIMBURSEMENT Reimbursement for Bond Issue Projects § 140.604 Reimbursable schedule. Projects to be financed from other than...

  12. 40 CFR 716.60 - Reporting schedule.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Reporting schedule. 716.60 Section 716.60 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT HEALTH AND SAFETY DATA REPORTING General Provisions § 716.60 Reporting schedule. (a) General requirements...

  13. 40 CFR 716.60 - Reporting schedule.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 32 2012-07-01 2012-07-01 false Reporting schedule. 716.60 Section 716.60 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT HEALTH AND SAFETY DATA REPORTING General Provisions § 716.60 Reporting schedule. (a) General requirements...

  14. 40 CFR 716.60 - Reporting schedule.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Reporting schedule. 716.60 Section 716.60 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT HEALTH AND SAFETY DATA REPORTING General Provisions § 716.60 Reporting schedule. (a) General requirements...

  15. 40 CFR 716.60 - Reporting schedule.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 31 2011-07-01 2011-07-01 false Reporting schedule. 716.60 Section 716.60 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT HEALTH AND SAFETY DATA REPORTING General Provisions § 716.60 Reporting schedule. (a) General requirements...

  16. 40 CFR 716.60 - Reporting schedule.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Reporting schedule. 716.60 Section 716.60 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT HEALTH AND SAFETY DATA REPORTING General Provisions § 716.60 Reporting schedule. (a) General requirements...

  17. 37 CFR 2.85 - Classification schedules.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2013-07-01 2013-07-01 false Classification schedules. 2..., DEPARTMENT OF COMMERCE RULES OF PRACTICE IN TRADEMARK CASES Classification § 2.85 Classification schedules. (a) International classification system. Section 6.1 of this chapter sets forth the international...

  18. 37 CFR 2.85 - Classification schedules.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2012-07-01 2012-07-01 false Classification schedules. 2..., DEPARTMENT OF COMMERCE RULES OF PRACTICE IN TRADEMARK CASES Classification § 2.85 Classification schedules. (a) International classification system. Section 6.1 of this chapter sets forth the international...

  19. 37 CFR 2.85 - Classification schedules.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2014-07-01 2014-07-01 false Classification schedules. 2..., DEPARTMENT OF COMMERCE RULES OF PRACTICE IN TRADEMARK CASES Classification § 2.85 Classification schedules. (a) International classification system. Section 6.1 of this chapter sets forth the international...

  20. 40 CFR 52.626 - Compliance schedules.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 3 2010-07-01 2010-07-01 false Compliance schedules. 52.626 Section 52.626 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS Hawaii § 52.626 Compliance schedules. (a) [Reserved] (b...

  1. 40 CFR 63.1102 - Compliance schedule.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 10 2010-07-01 2010-07-01 false Compliance schedule. 63.1102 Section 63.1102 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED... Technology Standards § 63.1102 Compliance schedule. (a) General requirements. Affected sources, as defined in...

  2. 5 CFR 293.511 - Retention schedule.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Retention schedule. 293.511 Section 293.511 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PERSONNEL RECORDS Employee Medical File System Records § 293.511 Retention schedule. (a) Temporary EMFS records must...

  3. 5 CFR 293.511 - Retention schedule.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 5 Administrative Personnel 1 2013-01-01 2013-01-01 false Retention schedule. 293.511 Section 293.511 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PERSONNEL RECORDS Employee Medical File System Records § 293.511 Retention schedule. (a) Temporary EMFS records must...

  4. 5 CFR 293.511 - Retention schedule.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 5 Administrative Personnel 1 2011-01-01 2011-01-01 false Retention schedule. 293.511 Section 293.511 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PERSONNEL RECORDS Employee Medical File System Records § 293.511 Retention schedule. (a) Temporary EMFS records must...

  5. 5 CFR 293.511 - Retention schedule.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 5 Administrative Personnel 1 2014-01-01 2014-01-01 false Retention schedule. 293.511 Section 293.511 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PERSONNEL RECORDS Employee Medical File System Records § 293.511 Retention schedule. (a) Temporary EMFS records must...

  6. 5 CFR 293.511 - Retention schedule.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 5 Administrative Personnel 1 2012-01-01 2012-01-01 false Retention schedule. 293.511 Section 293.511 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PERSONNEL RECORDS Employee Medical File System Records § 293.511 Retention schedule. (a) Temporary EMFS records must...

  7. 37 CFR 2.85 - Classification schedules.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2011-07-01 2011-07-01 false Classification schedules. 2..., DEPARTMENT OF COMMERCE RULES OF PRACTICE IN TRADEMARK CASES Classification § 2.85 Classification schedules. (a) International classification system. Section 6.1 of this chapter sets forth the international...

  8. 37 CFR 2.85 - Classification schedules.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Classification schedules. 2..., DEPARTMENT OF COMMERCE RULES OF PRACTICE IN TRADEMARK CASES Classification § 2.85 Classification schedules. (a) International classification system. Section 6.1 of this chapter sets forth the international...

  9. 40 CFR 52.1175 - Compliance schedules.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 4 2011-07-01 2011-07-01 false Compliance schedules. 52.1175 Section...) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS (CONTINUED) Michigan § 52.1175 Compliance schedules. (a... Rule 336.49 of the Michigan Air Pollution Control Commission provides for individual compliance...

  10. 49 CFR 237.101 - Scheduling of bridge inspections.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 4 2011-10-01 2011-10-01 false Scheduling of bridge inspections. 237.101 Section... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION BRIDGE SAFETY STANDARDS Bridge Inspection § 237.101 Scheduling of bridge inspections. (a) Each bridge management program shall include a provision for scheduling an...

  11. 49 CFR 237.101 - Scheduling of bridge inspections.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Scheduling of bridge inspections. 237.101 Section... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION BRIDGE SAFETY STANDARDS Bridge Inspection § 237.101 Scheduling of bridge inspections. (a) Each bridge management program shall include a provision for scheduling an...

  12. 77 FR 64032 - Schedules of Controlled Substances: Extension of Temporary Placement of Methylone Into Schedule I...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-18

    ... is possible, will remain in effect until April 20, 2013, or until rulemaking proceedings are... isomers is possible, into Schedule I of the Controlled Substances Act (CSA). The temporary scheduling of... to the public safety pursuant to 21 U.S.C. 811(h)(1). At the time the Final Order took effect...

  13. Scheduling Independent Partitions in Integrated Modular Avionics Systems

    PubMed Central

    Du, Chenglie; Han, Pengcheng

    2016-01-01

    Recently the integrated modular avionics (IMA) architecture has been widely adopted by the avionics industry due to its strong partition mechanism. Although the IMA architecture can achieve effective cost reduction and reliability enhancement in the development of avionics systems, it results in a complex allocation and scheduling problem. All partitions in an IMA system should be integrated together according to a proper schedule such that their deadlines will be met even under the worst case situations. In order to help provide a proper scheduling table for all partitions in IMA systems, we study the schedulability of independent partitions on a multiprocessor platform in this paper. We firstly present an exact formulation to calculate the maximum scaling factor and determine whether all partitions are schedulable on a limited number of processors. Then with a Game Theory analogy, we design an approximation algorithm to solve the scheduling problem of partitions, by allowing each partition to optimize its own schedule according to the allocations of the others. Finally, simulation experiments are conducted to show the efficiency and reliability of the approach proposed in terms of time consumption and acceptance ratio. PMID:27942013

  14. Clinical outcome of an alternative fotemustine schedule in elderly patients with recurrent glioblastoma: a mono-institutional retrospective study.

    PubMed

    Lombardi, Giuseppe; Bellu, Luisa; Pambuku, Ardi; Della Puppa, Alessandro; Fiduccia, Pasquale; Farina, Miriam; D'Avella, Domenico; Zagonel, Vittorina

    2016-07-01

    The optimal treatment of recurrent glioblastoma (GBM) in elderly patients is unclear. Fotemustine (FTM) is a third-generation nitrosourea showing efficacy in gliomas and it has been used with different schedules in adult patients. We performed, for the first time anywhere, a mono-institutional retrospective study to analyze the clinical outcome of an alternative fotemustine schedule in elderly patients with recurrent GBM. Retrospectively, we analyzed all GBM patients 65 years or older previously treated with the combination of radiation therapy and temozolomide (TMZ), receiving an alternative FTM schedule as second-line treatment at our Oncological Center from October 2011 to October 2014 with an ECOG PS ≤ 2. FTM was administrated at 80 mg/m(2) every 2 weeks for five consecutive administrations (induction phase), and then every 4 weeks at 80 mg/m(2) as maintenance. We enrolled 44 patients, 33 males and 11 females; average age was 70 years. ECOG PS was 0-1 in 80 % of the patients. 38 patients relapsed during temozolomide (TMZ) therapy. MGMT methylation status was analyzed in 34 patients and MGMT was methylated in 53 % of the patients. The median progression free survival (PFS) and overall survival (OS) from FTM treatment was 4.1 months (95 % CI 3.1-5.2) and 7 months (95 % CI 5.2-8.4), respectively. Patients with MGMT methylated status and patients who relapsed after completing TMZ therapy had a longer PFS and OS from the beginning of FTM. Thrombocytopenia was the most frequent grade 3-4 haematological toxicity (9 %). The alternative schedule of FTM may be an active and safe treatment for elderly patients with recurrent glioblastoma, especially patients with methylated MGMT and who relapsed after completing temozolomide therapy.

  15. 77 FR 10391 - Harmonizing Schedule I Drug Requirements

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-22

    ... [Docket No. FMCSA-2011-0073] RIN 2126-AB35 Harmonizing Schedule I Drug Requirements AGENCY: Federal Motor... the medical examination report to clarify that drivers may not use Schedule I drugs and be qualified...; email: [email protected] . SUPPLEMENTARY INFORMATION: FMCSA's recent rule harmonizing Schedule I drug...

  16. Timing Is Everything: Adapting to the Flexible Schedule.

    ERIC Educational Resources Information Center

    Browne, Karen Stevens; Burton, Linda

    1989-01-01

    Discusses the benefits of flexible scheduling in school media centers and emphasizes the importance of cooperation among media specialists, teachers, administrators, and volunteers in successfully implementing flexible scheduling. The experiences of a school media specialist who introduced flexible scheduling in the media center at Whiskey Bottom…

  17. 29 CFR 1952.241 - Developmental schedule.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... extended training plan of substantially permanent form will be developed and adopted by October 1, 1976. (e... (CONTINUED) APPROVED STATE PLANS FOR ENFORCEMENT OF STATE STANDARDS Alaska § 1952.241 Developmental schedule. The Alaska plan is developmental. The Schedule of developmental steps (described in the plan as...

  18. 29 CFR 1952.371 - Developmental schedule.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... (CONTINUED) APPROVED STATE PLANS FOR ENFORCEMENT OF STATE STANDARDS Virginia § 1952.371 Developmental schedule. The Virginia plan is developmental. Following is a schedule of major developmental steps: (a) Standards identical to the Federal standards will be completely adopted by January 1, 1978. (b) A plan for...

  19. 29 CFR 1952.371 - Developmental schedule.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... (CONTINUED) APPROVED STATE PLANS FOR ENFORCEMENT OF STATE STANDARDS Virginia § 1952.371 Developmental schedule. The Virginia plan is developmental. Following is a schedule of major developmental steps: (a) Standards identical to the Federal standards will be completely adopted by January 1, 1978. (b) A plan for...

  20. 29 CFR 1952.371 - Developmental schedule.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... (CONTINUED) APPROVED STATE PLANS FOR ENFORCEMENT OF STATE STANDARDS Virginia § 1952.371 Developmental schedule. The Virginia plan is developmental. Following is a schedule of major developmental steps: (a) Standards identical to the Federal standards will be completely adopted by January 1, 1978. (b) A plan for...

  1. 29 CFR 1952.371 - Developmental schedule.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... (CONTINUED) APPROVED STATE PLANS FOR ENFORCEMENT OF STATE STANDARDS Virginia § 1952.371 Developmental schedule. The Virginia plan is developmental. Following is a schedule of major developmental steps: (a) Standards identical to the Federal standards will be completely adopted by January 1, 1978. (b) A plan for...

  2. Planning and scheduling for success

    NASA Technical Reports Server (NTRS)

    Manzanera, Ignacio

    1994-01-01

    Planning and scheduling programs are excellent management tools when properly introduced to the project management team and regularly maintained. Communications, creativity, flexibility and accuracy are substantially improved by following a simple set of rules. A planning and scheduling program will work for you if you believe in it, make others in your project team realize its benefits, and make it an extension of your project cost control philosophy.

  3. Littoral Combat Ship Crew Scheduling

    DTIC Science & Technology

    2015-03-01

    events and schedules. The selection of u for each sub-problem also has the same tradeoff considerations of balancing solve time and overly myopic ...extending them beyond four months in a phase. Results are compared based on solve time and penalty value. The MIP solution has the best quality...benefits to crew alignment for longer-range schedules. The planner must balance solve time and solution quality when determining the approach to

  4. Multi-criteria evaluation methods in the production scheduling

    NASA Astrophysics Data System (ADS)

    Kalinowski, K.; Krenczyk, D.; Paprocka, I.; Kempa, W.; Grabowik, C.

    2016-08-01

    The paper presents a discussion on the practical application of different methods of multi-criteria evaluation in the process of scheduling in manufacturing systems. Among the methods two main groups are specified: methods based on the distance function (using metacriterion) and methods that create a Pareto set of possible solutions. The basic criteria used for scheduling were also described. The overall procedure of evaluation process in production scheduling was presented. It takes into account the actions in the whole scheduling process and human decision maker (HDM) participation. The specified HDM decisions are related to creating and editing a set of evaluation criteria, selection of multi-criteria evaluation method, interaction in the searching process, using informal criteria and making final changes in the schedule for implementation. According to need, process scheduling may be completely or partially automated. Full automatization is possible in case of metacriterion based objective function and if Pareto set is selected - the final decision has to be done by HDM.

  5. Future Air Traffic Growth and Schedule Model, Supplement

    NASA Technical Reports Server (NTRS)

    Kimmel, William M. (Technical Monitor); Smith, Jeremy C.; Dollyhigh, Samuel M.

    2004-01-01

    The Future Air Traffic Growth and Schedule Model was developed as an implementation of the Fratar algorithm to project future traffic flow between airports in a system and of then scheduling the additional flights to reflect current passenger time-of-travel preferences. The methodology produces an unconstrained future schedule from a current (or baseline) schedule and the airport operations growth rates. As an example of the use of the model, future schedules are projected for 2010 and 2022 for all flights arriving at, departing from, or flying between all continental United States airports that had commercial scheduled service for May 17, 2002. Inter-continental US traffic and airports are included and the traffic is also grown with the Fratar methodology to account for their arrivals and departures to the continental US airports. Input data sets derived from the Official Airline Guide (OAG) data and FAA Terminal Area Forecast (TAF) are included in the examples of the computer code execution.

  6. FASTER - A tool for DSN forecasting and scheduling

    NASA Technical Reports Server (NTRS)

    Werntz, David; Loyola, Steven; Zendejas, Silvino

    1993-01-01

    FASTER (Forecasting And Scheduling Tool for Earth-based Resources) is a suite of tools designed for forecasting and scheduling JPL's Deep Space Network (DSN). The DSN is a set of antennas and other associated resources that must be scheduled for satellite communications, astronomy, maintenance, and testing. FASTER consists of MS-Windows based programs that replace two existing programs (RALPH and PC4CAST). FASTER was designed to be more flexible, maintainable, and user friendly. FASTER makes heavy use of commercial software to allow for customization by users. FASTER implements scheduling as a two pass process: the first pass calculates a predictive profile of resource utilization; the second pass uses this information to calculate a cost function used in a dynamic programming optimization step. This information allows the scheduler to 'look ahead' at activities that are not as yet scheduled. FASTER has succeeded in allowing wider access to data and tools, reducing the amount of effort expended and increasing the quality of analysis.

  7. 32 CFR 204.9 - Schedule of fees and rates.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 2 2014-07-01 2014-07-01 false Schedule of fees and rates. 204.9 Section 204.9 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS USER FEES § 204.9 Schedule of fees and rates. (a) Schedule of fees and rates. (1) This schedule...

  8. Incubation lighting schedules and their interaction with matched or mismatched post hatch lighting schedules: Effects on broiler bone development and leg health at slaughter age.

    PubMed

    van der Pol, Carla W; van Roovert-Reijrink, Inge A M; Aalbers, Gerald; Kemp, Bas; van den Brand, Henry

    2017-10-01

    The incidence of leg pathologies in broiler chickens with a developmental origin may be decreased by stimulating embryonic bone development through lighting schedules during incubation, but this may depend on post hatch lighting conditions. Aim was to investigate how lighting schedules during incubation and their interactions with matched or mismatched lighting schedules post hatch affected bone development and leg health at slaughter age. In a 3×2 factorial designed experiment, eggs were incubated under continuous cool white LED light (Inc 24L ), 16h of light, 8h of darkness (Inc 16L:8D ), or continuous darkness (Inc 24D ) from set till hatch. After hatch, broilers were housed under continuous light (PH 24L , to match Inc 24L and Inc 24D ) or 16h of light, 8h of darkness (PH 16L:8D , to match Inc 16L:8D ). Gait scores were determined on D21, D28, and D34. After slaughter on D35, legs were scored for varus-valgus deformities, rotated tibia, tibial dyschondroplasia, bacterial chondronecrosis with osteomyelitis (BCO), epiphyseolysis, and epiphyseal plate abnormalities from 1=absent to 4=severe. Femur and tibia dimensions and mineral density were determined. Inc 24L led to more epiphyseal plate abnormalities than Inc 16L:8D or Inc 24D . Inc 24D led to more BCO than Inc 16L:8D . Gait scores on D21, D28, and D34, and bone dimensions did not differ between treatments. Inc 24L led to higher femur mineral density than Inc 24D with Inc 16L:8D intermediate. Providing a chicken with a matched post hatch lighting schedule did not affect most measurements of bone development and health. It can be concluded that a circadian incubation lighting schedule may improve leg health in broilers. Copyright © 2017 Elsevier Ltd. All rights reserved.

  9. Analysis of sequencing and scheduling methods for arrival traffic

    NASA Technical Reports Server (NTRS)

    Neuman, Frank; Erzberger, Heinz

    1990-01-01

    The air traffic control subsystem that performs scheduling is discussed. The function of the scheduling algorithms is to plan automatically the most efficient landing order and to assign optimally spaced landing times to all arrivals. Several important scheduling algorithms are described and the statistical performance of the scheduling algorithms is examined. Scheduling brings order to an arrival sequence for aircraft. First-come-first-served scheduling (FCFS) establishes a fair order, based on estimated times of arrival, and determines proper separations. Because of the randomness of the traffic, gaps will remain in the scheduled sequence of aircraft. These gaps are filled, or partially filled, by time-advancing the leading aircraft after a gap while still preserving the FCFS order. Tightly scheduled groups of aircraft remain with a mix of heavy and large aircraft. Separation requirements differ for different types of aircraft trailing each other. Advantage is taken of this fact through mild reordering of the traffic, thus shortening the groups and reducing average delays. Actual delays for different samples with the same statistical parameters vary widely, especially for heavy traffic.

  10. Incremental Scheduling Engines for Human Exploration of the Cosmos

    NASA Technical Reports Server (NTRS)

    Jaap, John; Phillips, Shaun

    2005-01-01

    As humankind embarks on longer space missions farther from home, the requirements and environments for scheduling the activities performed on these missions are changing. As we begin to prepare for these missions it is appropriate to evaluate the merits and applicability of the different types of scheduling engines. Scheduling engines temporally arrange tasks onto a timeline so that all constraints and objectives are met and resources are not overbooked. Scheduling engines used to schedule space missions fall into three general categories: batch, mixed-initiative, and incremental. This paper presents an assessment of the engine types, a discussion of the impact of human exploration of the moon and Mars on planning and scheduling, and the applicability of the different types of scheduling engines. This paper will pursue the hypothesis that incremental scheduling engines may have a place in the new environment; they have the potential to reduce cost, to improve the satisfaction of those who execute or benefit from a particular timeline (the customers), and to allow astronauts to plan their own tasks and those of their companion robots.

  11. A Program Master Schedule Can Improve Results

    DTIC Science & Technology

    2014-02-01

    A Program Master Schedule Can Improve Results Patrick K. Barker “There cannot be a crisis today; my schedule is already full.” —Henry Kissinger...often necessary—for clear communication . However, over-reliance on eye-pleasing graphics risks projecting a false impression of SA over a dy- namic...for poor scheduling discipline, lack of believability and/or poor communication . As the saying goes, garbage in equals garbage out. On the other

  12. Management of Temporal Constraints for Factory Scheduling.

    DTIC Science & Technology

    1987-06-01

    consistency of scheduling decisions were implemented in both the ISIS [Fox 84] and SOJA [LePape 85a] scheduling systems. More recent work with the...kinds of time propagation systems: the symbolic and the numeric ones. Symbolic systems combine relationships with a temporal logic a la Allen [Allen 81...maintains consistency by narrowing time windows associated with activities as decisions are made, and SOJA [LePape 85b] guarantees a schedule’s

  13. COMPASS: A general purpose computer aided scheduling tool

    NASA Technical Reports Server (NTRS)

    Mcmahon, Mary Beth; Fox, Barry; Culbert, Chris

    1991-01-01

    COMPASS is a generic scheduling system developed by McDonnell Douglas under the direction of the Software Technology Branch at JSC. COMPASS is intended to illustrate the latest advances in scheduling technology and provide a basis from which custom scheduling systems can be built. COMPASS was written in Ada to promote readability and to conform to potential NASA Space Station Freedom standards. COMPASS has some unique characteristics that distinguishes it from commercial products. These characteristics are discussed and used to illustrate some differences between scheduling tools.

  14. Childhood Vaccine Schedule

    MedlinePlus

    ... Navigation Bar Home Current Issue Past Issues Childhood Vaccine Schedule Past Issues / Spring 2008 Table of Contents ... please turn Javascript on. When to Vaccinate What Vaccine Why Birth (or any age if not previously ...

  15. Dry kiln schedules for commercial woods : temperate and tropical

    Treesearch

    R. Sidney Boone; Charles J. Kozlik; Paul J. Bois; Eugene M. Wengert

    1988-01-01

    This report contains suggested dry kiln schedules for over 500 commercial woods, both temperate and tropical. Kiln schedules are completely assembled and written out for easy use. Schedules for several thicknesses and specialty products (e.g. squares, handle stock, gunstock blanks) are given for many species. The majority of the schedules are from the world literature...

  16. Genetic algorithm to solve the problems of lectures and practicums scheduling

    NASA Astrophysics Data System (ADS)

    Syahputra, M. F.; Apriani, R.; Sawaluddin; Abdullah, D.; Albra, W.; Heikal, M.; Abdurrahman, A.; Khaddafi, M.

    2018-02-01

    Generally, the scheduling process is done manually. However, this method has a low accuracy level, along with possibilities that a scheduled process collides with another scheduled process. When doing theory class and practicum timetable scheduling process, there are numerous problems, such as lecturer teaching schedule collision, schedule collision with another schedule, practicum lesson schedules that collides with theory class, and the number of classrooms available. In this research, genetic algorithm is implemented to perform theory class and practicum timetable scheduling process. The algorithm will be used to process the data containing lists of lecturers, courses, and class rooms, obtained from information technology department at University of Sumatera Utara. The result of scheduling process using genetic algorithm is the most optimal timetable that conforms to available time slots, class rooms, courses, and lecturer schedules.

  17. 7 CFR 3011.6 - Fee schedule.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 15 2010-01-01 2010-01-01 false Fee schedule. 3011.6 Section 3011.6 Agriculture Regulations of the Department of Agriculture (Continued) OFFICE OF THE CHIEF FINANCIAL OFFICER, DEPARTMENT OF AGRICULTURE AVAILABILITY OF INFORMATION TO THE PUBLIC § 3011.6 Fee schedule. Departmental regulations provide...

  18. 40 CFR 58.12 - Operating schedules.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...) AMBIENT AIR QUALITY SURVEILLANCE Monitoring Network § 58.12 Operating schedules. State and local... part. Area-specific PAMS operating schedules must be included as part of the PAMS network description... remains once every six days. No less frequently than as part of each 5-year network assessment, the most...

  19. 40 CFR 58.12 - Operating schedules.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...) AMBIENT AIR QUALITY SURVEILLANCE Monitoring Network § 58.12 Operating schedules. State and local... part. Area-specific PAMS operating schedules must be included as part of the PAMS network description... remains once every six days. No less frequently than as part of each 5-year network assessment, the most...

  20. Randomised phase 3 open-label trial of first-line treatment with gemcitabine in association with docetaxel or paclitaxel in women with metastatic breast cancer: a comparison of different schedules and treatments

    PubMed Central

    2013-01-01

    Background This open-label study compared docetaxel/gemcitabine vs. paclitaxel/gemcitabine and a weekly (W) vs. 3-weekly (3 W) schedule in metastatic breast cancer (MBC). Methods Patients relapsed after adjuvant/neoadjuvant anthracycline-containing chemotherapy were randomized to: A) gemcitabine 1000 mg/m2 Day 1,8 + docetaxel 75 mg/m2 Day 1 q3W; B) gemcitabine 1250 mg/m2 Day 1,8 + paclitaxel 175 mg/m2 Day 1 q3W; C) gemcitabine 800 mg/m2 Day 1,8,15 + docetaxel 30 mg/m2 Day 1,8,15 q4W; D) gemcitabine 800 mg/m2 Day 1,15 + paclitaxel 80 mg/m2 Day 1,8,15 q4W. Primary endpoint was time-to-progression (TTP). Secondary endpoints were overall survival (OS) and overall response rate (ORR). Results Interim analysis led to accrual interruption (241 patients enrolled of 360 planned). Median TTP (months) was 8.33 (95% CI: 6.19-10.16) with W and 7.51 (95% CI: 5.93-8.33) with 3 W (p=0.319). No differences were observed in median TTP between docetaxel and paclitaxel, with 85.6% and 87.0% of patients progressing, respectively. OS did not differ between regimens/schedules. ORR was comparable between regimens (HR: 0.882; 95% CI: 0.523-1.488; p=0.639), while it was significantly higher in W than in the 3 W (HR: 0.504; 95% CI: 0.299-0.850; p=0.010) schedule. Grade 3/4 toxicities occurred in 69.2% and 71.9% of patients on docetaxel and paclitaxel, and in 65.8% and 75.2% in W and 3 W. Conclusions Both treatment regimens showed similar TTP. W might be associated with a better tumour response compared with 3 W. Trial registration Clinicaltrial.gov ID NCT00236899 PMID:23537313

  1. An Enabling Technology for New Planning and Scheduling Paradigms

    NASA Technical Reports Server (NTRS)

    Jaap, John; Davis, Elizabeth

    2004-01-01

    The Night Projects Directorate at NASA's Marshall Space Flight Center is developing a new planning and scheduling environment and a new scheduling algorithm to enable a paradigm shift in planning and scheduling concepts. Over the past 33 years Marshall has developed and evolved a paradigm for generating payload timelines for Skylab, Spacelab, various other Shuttle payloads, and the International Space Station. The current paradigm starts by collecting the requirements, called ?ask models," from the scientists and technologists for the tasks that are to be scheduled. Because of shortcomings in the current modeling schema, some requirements are entered as notes. Next, a cadre with knowledge of vehicle and hardware modifies these models to encompass and be compatible with the hardware model; again, notes are added when the modeling schema does not provide a better way to represent the requirements. Finally, the models are modified to be compatible with the scheduling engine. Then the models are submitted to the scheduling engine for automatic scheduling or, when requirements are expressed in notes, the timeline is built manually. A future paradigm would provide a scheduling engine that accepts separate science models and hardware models. The modeling schema would have the capability to represent all the requirements without resorting to notes. Furthermore, the scheduling engine would not require that the models be modified to account for the capabilities (limitations) of the scheduling engine. The enabling technology under development at Marshall has three major components: (1) A new modeling schema allows expressing all the requirements of the tasks without resorting to notes or awkward contrivances. The chosen modeling schema is both maximally expressive and easy to use. It utilizes graphical methods to show hierarchies of task constraints and networks of temporal relationships. (2) A new scheduling algorithm automatically schedules the models without the

  2. Request-Driven Schedule Automation for the Deep Space Network

    NASA Technical Reports Server (NTRS)

    Johnston, Mark D.; Tran, Daniel; Arroyo, Belinda; Call, Jared; Mercado, Marisol

    2010-01-01

    The DSN Scheduling Engine (DSE) has been developed to increase the level of automated scheduling support available to users of NASA s Deep Space Network (DSN). We have adopted a request-driven approach to DSN scheduling, in contrast to the activity-oriented approach used up to now. Scheduling requests allow users to declaratively specify patterns and conditions on their DSN service allocations, including timing, resource requirements, gaps, overlaps, time linkages among services, repetition, priorities, and a wide range of additional factors and preferences. The DSE incorporates a model of the key constraints and preferences of the DSN scheduling domain, along with algorithms to expand scheduling requests into valid resource allocations, to resolve schedule conflicts, and to repair unsatisfied requests. We use time-bounded systematic search with constraint relaxation to return nearby solutions if exact ones cannot be found, where the relaxation options and order are under user control. To explore the usability aspects of our approach we have developed a graphical user interface incorporating some crucial features to make it easier to work with complex scheduling requests. Among these are: progressive revelation of relevant detail, immediate propagation and visual feedback from a user s decisions, and a meeting calendar metaphor for repeated patterns of requests. Even as a prototype, the DSE has been deployed and adopted as the initial step in building the operational DSN schedule, thus representing an important initial validation of our overall approach. The DSE is a core element of the DSN Service Scheduling Software (S(sup 3)), a web-based collaborative scheduling system now under development for deployment to all DSN users.

  3. A theory of behaviour on progressive ratio schedules, with applications in behavioural pharmacology.

    PubMed

    Bradshaw, C M; Killeen, P R

    2012-08-01

    Mathematical principles of reinforcement (MPR) provide the theoretical basis for a family of models of schedule-controlled behaviour. A model of fixed-ratio schedule performance that was applied to behaviour on progressive ratio (PR) schedules showed systematic departures from the data. This study aims to derive a new model from MPR that will account for overall and running response rates in the component ratios of PR schedules, and their decline toward 0, the breakpoint. The role of pausing is represented in a real-time model containing four parameters: T (0) and k are the intercept and slope of the linear relation between post-reinforcement pause duration and the prior inter-reinforcer interval; a (specific activation) measures the incentive value of the reinforcer; δ (response time) sets biomechanical limits on response rate. Running rate is predicted to decrease with negative acceleration as ratio size increments, overall rate to increase and then decrease. Differences due to type of progression are explained as hysteresis in the control by reinforcement rates. Re-analysis of extant data focuses on the effects of acute treatment with antipsychotic drugs, lesions of the nucleus accumbens core, and destruction of orexinergic neurones of the lateral hypothalamus. The new model resolves some anomalies evident in earlier analyses, and provides new insights to the results of these interventions. Because they can render biologically relevant parameters, mathematical models can provide greater power in interpreting the effects of interventions on the processes underlying schedule-controlled behaviour than is possible for first-order data such as the breakpoint.

  4. Experiments with a decision-theoretic scheduler

    NASA Technical Reports Server (NTRS)

    Hansson, Othar; Holt, Gerhard; Mayer, Andrew

    1992-01-01

    This paper describes DTS, a decision-theoretic scheduler designed to employ state-of-the-art probabilistic inference technology to speed the search for efficient solutions to constraint-satisfaction problems. Our approach involves assessing the performance of heuristic control strategies that are normally hard-coded into scheduling systems, and using probabilistic inference to aggregate this information in light of features of a given problem. BPS, the Bayesian Problem-Solver, introduced a similar approach to solving single-agent and adversarial graph search problems, yielding orders-of-magnitude improvement over traditional techniques. Initial efforts suggest that similar improvements will be realizable when applied to typical constraint-satisfaction scheduling problems.

  5. Compiling Planning into Scheduling: A Sketch

    NASA Technical Reports Server (NTRS)

    Bedrax-Weiss, Tania; Crawford, James M.; Smith, David E.

    2004-01-01

    Although there are many approaches for compiling a planning problem into a static CSP or a scheduling problem, current approaches essentially preserve the structure of the planning problem in the encoding. In this pape: we present a fundamentally different encoding that more accurately resembles a scheduling problem. We sketch the approach and argue, based on an example, that it is possible to automate the generation of such an encoding for problems with certain properties and thus produce a compiler of planning into scheduling problems. Furthermore we argue that many NASA problems exhibit these properties and that such a compiler would provide benefits to both theory and practice.

  6. The MICRO-BOSS scheduling system: Current status and future efforts

    NASA Technical Reports Server (NTRS)

    Sadeh, Norman M.

    1993-01-01

    In this paper, a micro-opportunistic approach to factory scheduling was described that closely monitors the evolution of bottlenecks during the construction of the schedule, and continuously redirects search towards the bottleneck that appears to be most critical. This approach differs from earlier opportunistic approaches, as it does not require scheduling large resource subproblems or large job subproblems before revising the current scheduling strategy. This micro-opportunistic approach was implemented in the context of the MICRO-BOSS factory scheduling system. A study comparing MICRO-BOSS against a macro-opportunistic scheduler suggests that the additional flexibility of the micro-opportunistic approach to scheduling generally yields important reductions in both tardiness and inventory.

  7. 7 CFR 1.18 - Fee schedule.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 1 2013-01-01 2013-01-01 false Fee schedule. 1.18 Section 1.18 Agriculture Office of the Secretary of Agriculture ADMINISTRATIVE REGULATIONS Official Records § 1.18 Fee schedule. Pursuant to § 2.28 of this title, the Chief Financial Officer is delegated authority to promulgate regulations...

  8. 10 CFR 51.15 - Time schedules.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Time schedules. 51.15 Section 51.15 Energy NUCLEAR... REGULATORY FUNCTIONS National Environmental Policy Act-Regulations Implementing Section 102(2) § 51.15 Time... proposed action or a petitioner for rulemaking shall, establish a time schedule for all or any constituent...

  9. 10 CFR 51.15 - Time schedules.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false Time schedules. 51.15 Section 51.15 Energy NUCLEAR... REGULATORY FUNCTIONS National Environmental Policy Act-Regulations Implementing Section 102(2) § 51.15 Time... proposed action or a petitioner for rulemaking shall, establish a time schedule for all or any constituent...

  10. 10 CFR 51.15 - Time schedules.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false Time schedules. 51.15 Section 51.15 Energy NUCLEAR... REGULATORY FUNCTIONS National Environmental Policy Act-Regulations Implementing Section 102(2) § 51.15 Time... proposed action or a petitioner for rulemaking shall, establish a time schedule for all or any constituent...

  11. 10 CFR 51.15 - Time schedules.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 2 2013-01-01 2013-01-01 false Time schedules. 51.15 Section 51.15 Energy NUCLEAR... REGULATORY FUNCTIONS National Environmental Policy Act-Regulations Implementing Section 102(2) § 51.15 Time... proposed action or a petitioner for rulemaking shall, establish a time schedule for all or any constituent...

  12. Management Matters. Changing to Flexible Scheduling

    ERIC Educational Resources Information Center

    Pappas, Marjorie L.

    2005-01-01

    Elementary school library media specialists state that one of the most frustrating issues they face is the fixed schedules in their library media centers. Beyond the cost effectiveness issue, the fixed schedule severely limits using the resources of the library media center for inquiry learning and collaborative teaching experiences between the…

  13. Observing the Use of Tactile Schedules

    ERIC Educational Resources Information Center

    Aasen, Gro; Naerland, Terje

    2014-01-01

    This article explores the use of tactile schedules in a heterogeneous sample of children with congenital blindness and varying degrees of additional disabilities. Basic conditions for the use of tactile schedules are proposed and discussed. Child behaviour indicative of some particular functions that can be attained with the use of tactile…

  14. The MICRO-BOSS scheduling system: Current status and future efforts

    NASA Technical Reports Server (NTRS)

    Sadeh, Norman M.

    1992-01-01

    In this paper, a micro-opportunistic approach to factory scheduling was described that closely monitors the evolution of bottlenecks during the construction of the schedule and continuously redirects search towards the bottleneck that appears to be most critical. This approach differs from earlier opportunistic approaches, as it does not require scheduling large resource subproblems or large job subproblems before revising the current scheduling strategy. This micro-opportunistic approach was implemented in the context of the MICRO-BOSS factory scheduling system. A study comparing MICRO-BOSS against a macro-opportunistic scheduler suggests that the additional flexibility of the micro-opportunistic approach to scheduling generally yields important reductions in both tardiness and inventory. Current research efforts include: adaptation of MICRO-BOSS to deal with sequence-dependent setups and development of micro-opportunistic reactive scheduling techniques that will enable the system to patch the schedule in the presence of contingencies such as machine breakdowns, raw materials arriving late, job cancellations, etc.

  15. Developing algorithm for the critical care physician scheduling

    NASA Astrophysics Data System (ADS)

    Lee, Hyojun; Pah, Adam; Amaral, Luis; Northwestern Memorial Hospital Collaboration

    Understanding the social network has enabled us to quantitatively study social phenomena such as behaviors in adoption and propagation of information. However, most work has been focusing on networks of large heterogeneous communities, and little attention has been paid to how work-relevant information spreads within networks of small and homogeneous groups of highly trained individuals, such as physicians. Within the professionals, the behavior patterns and the transmission of information relevant to the job are dependent not only on the social network between the employees but also on the schedules and teams that work together. In order to systematically investigate the dependence of the spread of ideas and adoption of innovations on a work-environment network, we sought to construct a model for the interaction network of critical care physicians at Northwestern Memorial Hospital (NMH) based on their work schedules. We inferred patterns and hidden rules from past work schedules such as turnover rates. Using the characteristics of the work schedules of the physicians and their turnover rates, we were able to create multi-year synthetic work schedules for a generic intensive care unit. The algorithm for creating shift schedules can be applied to other schedule dependent networks ARO1.

  16. Registration Review Schedules

    EPA Pesticide Factsheets

    This schedule indicates plans for completion of risk assessments, proposed interim decisions and interim decisions for pesticides in the Registration Review program, EPA reviews all registered pesticides at least every 15 years as required by FIFRA.

  17. Scheduling Future Water Supply Investments Under Uncertainty

    NASA Astrophysics Data System (ADS)

    Huskova, I.; Matrosov, E. S.; Harou, J. J.; Kasprzyk, J. R.; Reed, P. M.

    2014-12-01

    Uncertain hydrological impacts of climate change, population growth and institutional changes pose a major challenge to planning of water supply systems. Planners seek optimal portfolios of supply and demand management schemes but also when to activate assets whilst considering many system goals and plausible futures. Incorporation of scheduling into the planning under uncertainty problem strongly increases its complexity. We investigate some approaches to scheduling with many-objective heuristic search. We apply a multi-scenario many-objective scheduling approach to the Thames River basin water supply system planning problem in the UK. Decisions include which new supply and demand schemes to implement, at what capacity and when. The impact of different system uncertainties on scheme implementation schedules are explored, i.e. how the choice of future scenarios affects the search process and its outcomes. The activation of schemes is influenced by the occurrence of extreme hydrological events in the ensemble of plausible scenarios and other factors. The approach and results are compared with a previous study where only the portfolio problem is addressed (without scheduling).

  18. Schedules of controlled substances: temporary placement of three synthetic phenethylamines into Schedule I. Final order.

    PubMed

    2013-11-15

    The Deputy Administrator of the Drug Enforcement Administration (DEA) is issuing this final order to temporarily schedule three synthetic phenethylamines into the Controlled Substances Act (CSA) pursuant to the temporary scheduling provisions of 21 U.S.C. 811(h). The substances are 2-(4-iodo-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamine (25I-NBOMe; 2C-I-NBOMe; 25I; Cimbi-5), 2-(4-chloro-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamine (25C-NBOMe; 2C-C-NBOMe; 25C; Cimbi-82), and 2-(4-bromo-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamine (25B-NBOMe; 2C-B-NBOMe; 25B; Cimbi-36) [hereinafter 25I-NBOMe, 25C-NBOMe, and 25B-NBOMe]. This action is based on a finding by the Deputy Administrator that the placement of these synthetic phenethylamines and their optical, positional, and geometric isomers, salts and salts of isomers in schedule I of the CSA is necessary to avoid an imminent hazard to the public safety. As a result of this order, the regulatory controls and administrative, civil, and criminal sanctions applicable to schedule I controlled substances will be imposed on persons who handle (manufacture, distribute, dispense, import, export, engage in research, conduct instructional activities, and possess), or propose to handle these synthetic phenethylamines.

  19. Performance analysis of a large-grain dataflow scheduling paradigm

    NASA Technical Reports Server (NTRS)

    Young, Steven D.; Wills, Robert W.

    1993-01-01

    A paradigm for scheduling computations on a network of multiprocessors using large-grain data flow scheduling at run time is described and analyzed. The computations to be scheduled must follow a static flow graph, while the schedule itself will be dynamic (i.e., determined at run time). Many applications characterized by static flow exist, and they include real-time control and digital signal processing. With the advent of computer-aided software engineering (CASE) tools for capturing software designs in dataflow-like structures, macro-dataflow scheduling becomes increasingly attractive, if not necessary. For parallel implementations, using the macro-dataflow method allows the scheduling to be insulated from the application designer and enables the maximum utilization of available resources. Further, by allowing multitasking, processor utilizations can approach 100 percent while they maintain maximum speedup. Extensive simulation studies are performed on 4-, 8-, and 16-processor architectures that reflect the effects of communication delays, scheduling delays, algorithm class, and multitasking on performance and speedup gains.

  20. Planning and Scheduling for Environmental Sensor Networks

    NASA Astrophysics Data System (ADS)

    Frank, J. D.

    2005-12-01

    Environmental Sensor Networks are a new way of monitoring the environment. They comprise autonomous sensor nodes in the environment that record real-time data, which is retrieved, analyzed, integrated with other data sets (e.g. satellite images, GIS, process models) and ultimately lead to scientific discoveries. Sensor networks must operate within time and resource constraints. Sensors have limited onboard memory, energy, computational power, communications windows and communications bandwidth. The value of data will depend on when, where and how it was collected, how detailed the data is, how long it takes to integrate the data, and how important the data was to the original scientific question. Planning and scheduling of sensor networks is necessary for effective, safe operations in the face of these constraints. For example, power bus limitations may preclude sensors from simultaneously collecting data and communicating without damaging the sensor; planners and schedulers can ensure these operations are ordered so that they do not happen simultaneously. Planning and scheduling can also ensure best use of the sensor network to maximize the value of collected science data. For example, if data is best recorded using a particular camera angle but it is costly in time and energy to achieve this, planners and schedulers can search for times when time and energy are available to achieve the optimal camera angle. Planning and scheduling can handle uncertainty in the problem specification; planners can be re-run when new information is made available, or can generate plans that include contingencies. For example, if bad weather may prevent the collection of data, a contingent plan can check lighting conditions and turn off data collection to save resources if lighting is not ideal. Both mobile and immobile sensors can benefit from planning and scheduling. For example, data collection on otherwise passive sensors can be halted to preserve limited power and memory

  1. Impact of concomitant dexamethasone dosing schedule on bortezomib-induced peripheral neuropathy in multiple myeloma.

    PubMed

    Kumar, Shaji K; Laubach, Jacob P; Giove, Thomas J; Quick, Maureen; Neuwirth, Rachel; Yung, Godwin; Rajkumar, S Vincent; Richardson, Paul G

    2017-09-01

    Peripheral neuropathy (PN) is the most troublesome adverse event associated with the proteasome inhibitor bortezomib. Studies suggest an inflammatory aetiology for bortezomib-induced PN (BiPN) and it has been hypothesized that reducing inflammation with concomitant dexamethasone may reduce BiPN incidence and/or severity. We retrospectively analysed PN rates from 32 studies (2697 patients with previously untreated multiple myeloma) incorporating bortezomib and differing dexamethasone schedules: partnered dosing (days of and after bortezomib), weekly dosing, and other dosing schedules (e.g. days 1-4, 8-11). Pooled overall PN rates were 45·5%, 63·9%, and 47·5%, respectively, with 5·3%, 11·0%, and 9·6% grade ≥3. Adjusting for potential confounders (age, gender, presence of thalidomide, bortezomib treatment duration), PN rates in patients on partnered dosing schedules appeared lower than in patients on weekly or other dosing schedules. Analyses conducted using patient-level data suggest that cumulative dexamethasone dose, a potential confounding factor, is unlikely to have influenced the analyses. Findings were similar in a separate pooled analysis excluding data from regimens incorporating thalidomide, when pooled overall PN rates were 50·1%, 63·9%, and 48·3%, respectively, with 4·2%, 11·0%, and 8·6% grade ≥3. These findings suggest that partnered dexamethasone dosing may result in less severe BiPN compared with alternative dexamethasone dosing schedules. © 2017 John Wiley & Sons Ltd.

  2. Project Scheduling Based on Risk of Gas Transmission Pipe

    NASA Astrophysics Data System (ADS)

    Silvianita; Nurbaity, A.; Mulyadi, Y.; Suntoyo; Chamelia, D. M.

    2018-03-01

    The planning of a project has a time limit on which must be completed before or right at a predetermined time. Thus, in a project planning, it is necessary to have scheduling management that is useful for completing a project to achieve maximum results by considering the constraints that will exists. Scheduling management is undertaken to deal with uncertainties and negative impacts of time and cost in project completion. This paper explains about scheduling management in gas transmission pipeline project Gresik-Semarang to find out which scheduling plan is most effectively used in accordance with its risk value. Scheduling management in this paper is assissted by Microsoft Project software to find the critical path of existing project scheduling planning data. Critical path is the longest scheduling path with the fastest completion time. The result is found a critical path on project scheduling with completion time is 152 days. Furthermore, the calculation of risk is done by using House of Risk (HOR) method and it is found that the critical path has a share of 40.98 percent of all causes of the occurence of risk events that will be experienced.

  3. Escalator: An Autonomous Scheduling Scheme for Convergecast in TSCH.

    PubMed

    Oh, Sukho; Hwang, DongYeop; Kim, Ki-Hyung; Kim, Kangseok

    2018-04-16

    Time Slotted Channel Hopping (TSCH) is widely used in the industrial wireless sensor networks due to its high reliability and energy efficiency. Various timeslot and channel scheduling schemes have been proposed for achieving high reliability and energy efficiency for TSCH networks. Recently proposed autonomous scheduling schemes provide flexible timeslot scheduling based on the routing topology, but do not take into account the network traffic and packet forwarding delays. In this paper, we propose an autonomous scheduling scheme for convergecast in TSCH networks with RPL as a routing protocol, named Escalator. Escalator generates a consecutive timeslot schedule along the packet forwarding path to minimize the packet transmission delay. The schedule is generated autonomously by utilizing only the local routing topology information without any additional signaling with other nodes. The generated schedule is guaranteed to be conflict-free, in that all nodes in the network could transmit packets to the sink in every slotframe cycle. We implement Escalator and evaluate its performance with existing autonomous scheduling schemes through a testbed and simulation. Experimental results show that the proposed Escalator has lower end-to-end delay and higher packet delivery ratio compared to the existing schemes regardless of the network topology.

  4. Parental work schedules and child overweight and obesity.

    PubMed

    Champion, S L; Rumbold, A R; Steele, E J; Giles, L C; Davies, M J; Moore, V M

    2012-04-01

    Studies in school-age children have consistently shown a positive association between maternal paid work hours and child obesity. However, there is conflicting evidence about the impact of maternal work hours scheduled at nonstandard times (for example, evenings, nights or weekends), and no previous examination of paternal work schedules and child weight. We examined the associations between maternal, paternal and combined parental paid work schedules and overweight/obesity in children at age 9 years. Data were analysed from the most recent follow-up of 9-year-old children (n=434) in an Australian birth cohort study. Children were measured and classified as overweight/obese using the International Obesity Taskforce body mass index cutoff points. Current working conditions of parents were obtained from a structured interview with the primary caregiver. Logistic regression analyses were used to investigate the effect of parental work schedules on child overweight/obesity with adjustment for a range of sociodemographic and household factors associated with parental employment and child weight. At 9 years of age, 99 children (22.8%) were overweight or obese. When parental work schedules were examined separately, child overweight/obesity was significantly associated with paternal nonstandard work schedules (adjusted odds ratio (OR) 1.97, 95% confidence interval (CI) 1.08-3.61). There was no association with any type of maternal work schedule. We also found an association between child overweight/obesity and circumstances in which both parents worked nonstandard schedules; however, this was of borderline statistical significance in the adjusted models (adjusted OR 2.26, 95% CI 0.99-5.16). Work hours scheduled at nonstandard times, when worked by the father or both parents, were associated with child overweight and obesity. These findings indicate the potential importance of fathers' paid work arrangements for child overweight/obesity, which until recently has largely

  5. 40 CFR 52.240 - Compliance schedules.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 3 2010-07-01 2010-07-01 false Compliance schedules. 52.240 Section 52.240 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS California § 52.240 Compliance schedules. (a) The requirements of § 51.262(a) of this chapter are...

  6. 40 CFR 52.240 - Compliance schedules.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 3 2013-07-01 2013-07-01 false Compliance schedules. 52.240 Section 52.240 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS California § 52.240 Compliance schedules. (a) The requirements of § 51.262(a) of this chapter are...

  7. 40 CFR 52.240 - Compliance schedules.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 3 2014-07-01 2014-07-01 false Compliance schedules. 52.240 Section 52.240 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS California § 52.240 Compliance schedules. (a) The requirements of § 51.262(a) of this chapter are...

  8. 40 CFR 52.240 - Compliance schedules.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 3 2012-07-01 2012-07-01 false Compliance schedules. 52.240 Section 52.240 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS California § 52.240 Compliance schedules. (a) The requirements of § 51.262(a) of this chapter are...

  9. 40 CFR 52.240 - Compliance schedules.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 3 2011-07-01 2011-07-01 false Compliance schedules. 52.240 Section 52.240 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS California § 52.240 Compliance schedules. (a) The requirements of § 51.262(a) of this chapter are...

  10. 20 CFR 402.165 - Fee schedule.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... § 402.165 Fee schedule. The following is our fee schedule for providing records and related services... as punchcards or blueprints, or reproducing other records such as tapes, we will charge the actual... are true copies. This service is not required by the FOIA. If we agree to provide it, we will charge...

  11. 16 CFR 1203.13 - Test schedule.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 16 Commercial Practices 2 2012-01-01 2012-01-01 false Test schedule. 1203.13 Section 1203.13... STANDARD FOR BICYCLE HELMETS The Standard § 1203.13 Test schedule. (a) Helmet sample 1 of the set of eight... environments, respectively) shall be tested in accordance with the dynamic retention system strength test at...

  12. 20 CFR 656.5 - Schedule A.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Schedule A may apply for that labor certification under § 656.15. Schedule A (a) Group I: (1) Persons who... National Council of State Boards of Nursing. (3) Definitions of Group I occupations: (i) Physical therapist... illness in others. A program of study for professional nurses generally includes theory and practice in...

  13. A NEW APPROACH TO CLASS SCHEDULING. FINAL REPORT.

    ERIC Educational Resources Information Center

    CANTER, JOHN; AND OTHERS

    AN INVESTIGATION OF THE USE OF A PROTOTYPE DEVICE FOR CLASS SCHEDULING WAS MADE. THE BEEKLEY INSITE DEVICE THAT WAS STUDIED USES THE "PEEK-A-BOO" PRINCIPLE OF MATCHING COMPUTER TAPES. A TEST GROUP OF 149 GRADUATE STUDENTS WAS USED. THEIR DESIRED SCHEDULES WERE MATCHED AUTOMATICALLY AGAINST A PROPOSED MASTER SCHEDULE TO EVALUATE THE…

  14. 14 CFR 323.16 - Listings in schedule publications.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 4 2011-01-01 2011-01-01 false Listings in schedule publications. 323.16... schedule publications. Each air carrier filing a notice under § 323.3 (a)(2), (a)(4), (a)(5), or (c) shall continue to list the affected flights in all generally-distributed schedule publications in which the...

  15. 14 CFR 323.16 - Listings in schedule publications.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 4 2014-01-01 2014-01-01 false Listings in schedule publications. 323.16... schedule publications. Each air carrier filing a notice under § 323.3 (a)(2), (a)(4), (a)(5), or (c) shall continue to list the affected flights in all generally-distributed schedule publications in which the...

  16. 14 CFR 323.16 - Listings in schedule publications.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 4 2012-01-01 2012-01-01 false Listings in schedule publications. 323.16... schedule publications. Each air carrier filing a notice under § 323.3 (a)(2), (a)(4), (a)(5), or (c) shall continue to list the affected flights in all generally-distributed schedule publications in which the...

  17. AI techniques for a space application scheduling problem

    NASA Technical Reports Server (NTRS)

    Thalman, N.; Sparn, T.; Jaffres, L.; Gablehouse, D.; Judd, D.; Russell, C.

    1991-01-01

    Scheduling is a very complex optimization problem which can be categorized as an NP-complete problem. NP-complete problems are quite diverse, as are the algorithms used in searching for an optimal solution. In most cases, the best solutions that can be derived for these combinatorial explosive problems are near-optimal solutions. Due to the complexity of the scheduling problem, artificial intelligence (AI) can aid in solving these types of problems. Some of the factors are examined which make space application scheduling problems difficult and presents a fairly new AI-based technique called tabu search as applied to a real scheduling application. the specific problem is concerned with scheduling application. The specific problem is concerned with scheduling solar and stellar observations for the SOLar-STellar Irradiance Comparison Experiment (SOLSTICE) instrument in a constrained environment which produces minimum impact on the other instruments and maximizes target observation times. The SOLSTICE instrument will gly on-board the Upper Atmosphere Research Satellite (UARS) in 1991, and a similar instrument will fly on the earth observing system (Eos).

  18. 75 FR 79296 - Schedules of Controlled Substances: Placement of 5-Methoxy-N,N-Dimethyltryptamine into Schedule I...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-20

    ...] Schedules of Controlled Substances: Placement of 5-Methoxy-N,N- Dimethyltryptamine into Schedule I of the... Administration (DEA) places the substance 5- methoxy-N,N-dimethyltryptamine (5-MeO-DMT), including its salts..., actual abuse, pattern of abuse, and the relative potential for abuse of 5-methoxy-N,N-dimethyltryptamine...

  19. Creative employee scheduling in the health information management department.

    PubMed

    Hyde, C S

    1998-02-01

    What effect do schedules have on employees and department activities? Negative effects such as backlogs, poor employee morale, and absenteeism may be due to scheduling practices currently in place. The value of effective employee scheduling practices may be seen in areas of improved productivity. The process of developing schedules should include assessing department areas, understanding operational needs, choosing an option, and implementation. Finding a schedule that meets the needs of managers as well as those of the employees is rewarding. It is a win-win situation, and the benefits can yield increased productivity, decreased turnover, and higher morale.

  20. 12 CFR 1005.36 - Transfers scheduled in advance.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ...: § 1005.36 Transfers scheduled before the date of transfer. (a) Timing. (1) For a one-time transfer...) For a one-time transfer scheduled five or more business days in advance or for the first in a series... 12 Banks and Banking 8 2013-01-01 2013-01-01 false Transfers scheduled in advance. 1005.36 Section...

  1. SOFIA's Choice: Automating the Scheduling of Airborne Observations

    NASA Technical Reports Server (NTRS)

    Frank, Jeremy; Norvig, Peter (Technical Monitor)

    1999-01-01

    This paper describes the problem of scheduling observations for an airborne telescope. Given a set of prioritized observations to choose from, and a wide range of complex constraints governing legitimate choices and orderings, how can we efficiently and effectively create a valid flight plan which supports high priority observations? This problem is quite different from scheduling problems which are routinely solved automatically in industry. For instance, the problem requires making choices which lead to other choices later, and contains many interacting complex constraints over both discrete and continuous variables. Furthermore, new types of constraints may be added as the fundamental problem changes. As a result of these features, this problem cannot be solved by traditional scheduling techniques. The problem resembles other problems in NASA and industry, from observation scheduling for rovers and other science instruments to vehicle routing. The remainder of the paper is organized as follows. In 2 we describe the observatory in order to provide some background. In 3 we describe the problem of scheduling a single flight. In 4 we compare flight planning and other scheduling problems and argue that traditional techniques are not sufficient to solve this problem. We also mention similar complex scheduling problems which may benefit from efforts to solve this problem. In 5 we describe an approach for solving this problem based on research into a similar problem, that of scheduling observations for a space-borne probe. In 6 we discuss extensions of the flight planning problem as well as other problems which are similar to flight planning. In 7 we conclude and discuss future work.

  2. Effect of Uncertainty on Deterministic Runway Scheduling

    NASA Technical Reports Server (NTRS)

    Gupta, Gautam; Malik, Waqar; Jung, Yoon C.

    2012-01-01

    Active runway scheduling involves scheduling departures for takeoffs and arrivals for runway crossing subject to numerous constraints. This paper evaluates the effect of uncertainty on a deterministic runway scheduler. The evaluation is done against a first-come- first-serve scheme. In particular, the sequence from a deterministic scheduler is frozen and the times adjusted to satisfy all separation criteria; this approach is tested against FCFS. The comparison is done for both system performance (throughput and system delay) and predictability, and varying levels of congestion are considered. The modeling of uncertainty is done in two ways: as equal uncertainty in availability at the runway as for all aircraft, and as increasing uncertainty for later aircraft. Results indicate that the deterministic approach consistently performs better than first-come-first-serve in both system performance and predictability.

  3. Class Scheduling: An Opportunity for Innovation.

    ERIC Educational Resources Information Center

    Stauffer, Gregory L.

    This paper addresses the role of college and university class scheduling in meeting the needs of its students. It first discusses the balancing of schedules in order to satisfy not only student needs, but also faculty interests and the administrative concerns relative to facility availability and funding support. Surveys are suggested as a good…

  4. 9 CFR 390.6 - Fee schedule.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 2 2012-01-01 2012-01-01 false Fee schedule. 390.6 Section 390.6 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE FOOD SAFETY AND INSPECTION SERVICE ADMINISTRATIVE PROVISIONS FREEDOM OF INFORMATION AND PUBLIC INFORMATION § 390.6 Fee schedule. Department regulations provide for...

  5. 9 CFR 390.6 - Fee schedule.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 2 2013-01-01 2013-01-01 false Fee schedule. 390.6 Section 390.6 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE FOOD SAFETY AND INSPECTION SERVICE ADMINISTRATIVE PROVISIONS FREEDOM OF INFORMATION AND PUBLIC INFORMATION § 390.6 Fee schedule. Department regulations provide for...

  6. 9 CFR 390.6 - Fee schedule.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 2 2011-01-01 2011-01-01 false Fee schedule. 390.6 Section 390.6 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE FOOD SAFETY AND INSPECTION SERVICE ADMINISTRATIVE PROVISIONS FREEDOM OF INFORMATION AND PUBLIC INFORMATION § 390.6 Fee schedule. Department regulations provide for...

  7. 9 CFR 390.6 - Fee schedule.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 2 2014-01-01 2014-01-01 false Fee schedule. 390.6 Section 390.6 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE FOOD SAFETY AND INSPECTION SERVICE ADMINISTRATIVE PROVISIONS FREEDOM OF INFORMATION AND PUBLIC INFORMATION § 390.6 Fee schedule. Department regulations provide for...

  8. State Teacher Salary Schedules. Policy Analysis

    ERIC Educational Resources Information Center

    Griffith, Michael

    2016-01-01

    In the United States most teacher compensation issues are decided at the school district level. However, a group of states have chosen to play a role in teacher pay decisions by instituting statewide teacher salary schedules. Education Commission of the States has found that 17 states currently make use of teacher salary schedules. This education…

  9. Responsive versus scheduled feeding for preterm infants.

    PubMed

    Watson, Julie; McGuire, William

    2015-10-13

    Feeding preterm infants in response to their hunger and satiation cues (responsive, cue-based, or infant-led feeding) rather than at scheduled intervals might enhance infants' and parents' experience and satisfaction, help in the establishment of independent oral feeding, increase nutrient intake and growth rates, and allow earlier hospital discharge. To assess the effect of feeding preterm infants on a responsive basis versus feeding prescribed volumes at scheduled intervals on growth, duration of hospital stay, and parental satisfaction. We used the standard search strategy of the Cochrane Neonatal Review Group. This included searches of the Cochrane Central Register of Controlled Trials (CENTRAL, The Cochrane Library, Issue 9, 2015), MEDLINE (1966 to September 2015), EMBASE (1980 to September 2015), and CINAHL (1982 to September 2015), conference proceedings, previous reviews, and trial registries. Randomised controlled trials (RCTs) or quasi-RCTs that compared a policy of feeding preterm infants on a responsive basis versus feeding at scheduled intervals. Two review authors assessed trial eligibility and risk of bias and undertook data extraction independently. We analysed the treatment effects in the individual trials and reported the risk ratio and risk difference for dichotomous data and mean difference (MD) for continuous data, with respective 95% confidence intervals (CIs). We used a fixed-effect model in meta-analyses and explored the potential causes of heterogeneity in sensitivity analyses. We found nine eligible RCTs including 593 infants in total. These trials compared responsive with scheduled interval regimens in preterm infants in the transition phase from intragastric tube to oral feeding. The trials were generally small and contained various methodological weaknesses including lack of blinding and incomplete assessment of all randomised participants. Meta-analyses, although limited by data quality and availability, suggest that responsive feeding

  10. Automated observation scheduling for the VLT

    NASA Technical Reports Server (NTRS)

    Johnston, Mark D.

    1988-01-01

    It is becoming increasingly evident that, in order to optimize the observing efficiency of large telescopes, some changes will be required in the way observations are planned and executed. Not all observing programs require the presence of the astronomer at the telescope: for those programs which permit service observing it is possible to better match planned observations to conditions at the telescope. This concept of flexible scheduling has been proposed for the VLT: based on current and predicted environmental and instrumental observations which make the most efficient possible use of valuable time. A similar kind of observation scheduling is already necessary for some space observatories, such as Hubble Space Telescope (HST). Space Telescope Science Institute is presently developing scheduling tools for HST, based on the use of artificial intelligence software development techniques. These tools could be readily adapted for ground-based telescope scheduling since they address many of the same issues. The concept are described on which the HST tools are based, their implementation, and what would be required to adapt them for use with the VLT and other ground-based observatories.

  11. Cost-efficient scheduling of FAST observations

    NASA Astrophysics Data System (ADS)

    Luo, Qi; Zhao, Laiping; Yu, Ce; Xiao, Jian; Sun, Jizhou; Zhu, Ming; Zhong, Yi

    2018-03-01

    A cost-efficient schedule for the Five-hundred-meter Aperture Spherical radio Telescope (FAST) requires to maximize the number of observable proposals and the overall scientific priority, and minimize the overall slew-cost generated by telescope shifting, while taking into account the constraints including the astronomical objects visibility, user-defined observable times, avoiding Radio Frequency Interference (RFI). In this contribution, first we solve the problem of maximizing the number of observable proposals and scientific priority by modeling it as a Minimum Cost Maximum Flow (MCMF) problem. The optimal schedule can be found by any MCMF solution algorithm. Then, for minimizing the slew-cost of the generated schedule, we devise a maximally-matchable edges detection-based method to reduce the problem size, and propose a backtracking algorithm to find the perfect matching with minimum slew-cost. Experiments on a real dataset from NASA/IPAC Extragalactic Database (NED) show that, the proposed scheduler can increase the usage of available times with high scientific priority and reduce the slew-cost significantly in a very short time.

  12. Heuristic-based scheduling algorithm for high level synthesis

    NASA Technical Reports Server (NTRS)

    Mohamed, Gulam; Tan, Han-Ngee; Chng, Chew-Lye

    1992-01-01

    A new scheduling algorithm is proposed which uses a combination of a resource utilization chart, a heuristic algorithm to estimate the minimum number of hardware units based on operator mobilities, and a list-scheduling technique to achieve fast and near optimal schedules. The schedule time of this algorithm is almost independent of the length of mobilities of operators as can be seen from the benchmark example (fifth order digital elliptical wave filter) presented when the cycle time was increased from 17 to 18 and then to 21 cycles. It is implemented in C on a SUN3/60 workstation.

  13. 76 FR 60359 - Phytosanitary Treatments; Location of and Process for Updating Treatment Schedules; Technical...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-29

    ... Treatment Manual, and we did not retain text explaining that irradiation can be used as a substitute for... irradiation treatment, respectively. Where these sections have referred to facilities capable of performing...)(1) stated that irradiation treatment in accordance with part 305 could be substituted for other...

  14. Automatic generation of efficient orderings of events for scheduling applications

    NASA Technical Reports Server (NTRS)

    Morris, Robert A.

    1994-01-01

    In scheduling a set of tasks, it is often not known with certainty how long a given event will take. We call this duration uncertainty. Duration uncertainty is a primary obstacle to the successful completion of a schedule. If a duration of one task is longer than expected, the remaining tasks are delayed. The delay may result in the abandonment of the schedule itself, a phenomenon known as schedule breakage. One response to schedule breakage is on-line, dynamic rescheduling. A more recent alternative is called proactive rescheduling. This method uses statistical data about the durations of events in order to anticipate the locations in the schedule where breakage is likely prior to the execution of the schedule. It generates alternative schedules at such sensitive points, which can be then applied by the scheduler at execution time, without the delay incurred by dynamic rescheduling. This paper proposes a technique for making proactive error management more effective. The technique is based on applying a similarity-based method of clustering to the problem of identifying similar events in a set of events.

  15. Four-Day Week Schedule. Research Brief

    ERIC Educational Resources Information Center

    Marx, Gary E.

    2007-01-01

    What does research say about the four-day week as an alternative school schedule? More than 100 districts in at least 12 states currently use a four-day week alternative schedule. Most are located in rural areas, serve less than 1000 students, and made the move to a shorter school week with longer instructional days for financial reasons. Although…

  16. Linear-parameter-varying gain-scheduled control of aerospace systems

    NASA Astrophysics Data System (ADS)

    Barker, Jeffrey Michael

    The dynamics of many aerospace systems vary significantly as a function of flight condition. Robust control provides methods of guaranteeing performance and stability goals across flight conditions. In mu-syntthesis, changes to the dynamical system are primarily treated as uncertainty. This method has been successfully applied to many control problems, and here is applied to flutter control. More recently, two techniques for generating robust gain-scheduled controller have been developed. Linear fractional transformation (LFT) gain-scheduled control is an extension of mu-synthesis in which the plant and controller are explicit functions of parameters measurable in real-time. This LFT gain-scheduled control technique is applied to the Benchmark Active Control Technology (BACT) wing, and compared with mu-synthesis control. Linear parameter-varying (LPV) gain-scheduled control is an extension of Hinfinity control to parameter varying systems. LPV gain-scheduled control directly incorporates bounds on the rate of change of the scheduling parameters, and often reduces conservatism inherent in LFT gain-scheduled control. Gain-scheduled LPV control of the BACT wing compares very favorably with the LFT controller. Gain-scheduled LPV controllers are generated for the lateral-directional and longitudinal axes of the Innovative Control Effectors (ICE) aircraft and implemented in nonlinear simulations and real-time piloted nonlinear simulations. Cooper-Harper and pilot-induced oscillation ratings were obtained for an initial design, a reference aircraft and a redesign. Piloted simulation results for the initial LPV gain-scheduled control of the ICE aircraft are compared with results for a conventional fighter aircraft in discrete pitch and roll angle tracking tasks. The results for the redesigned controller are significantly better than both the previous LPV controller and the conventional aircraft.

  17. Automated Long - Term Scheduling for the SOFIA Airborne Observatory

    NASA Technical Reports Server (NTRS)

    Civeit, Thomas

    2013-01-01

    The NASA Stratospheric Observatory for Infrared Astronomy (SOFIA) is a joint US/German project to develop and operate a gyro-stabilized 2.5-meter telescope in a Boeing 747SP. SOFIA's first science observations were made in December 2010. During 2011, SOFIA accomplished 30 flights in the "Early Science" program as well as a deployment to Germany. The new observing period, known as Cycle 1, is scheduled to begin in 2012. It includes 46 science flights grouped in four multi-week observing campaigns spread through a 13-month span. Automation of the flight scheduling process offers a major challenge to the SOFIA mission operations. First because it is needed to mitigate its relatively high cost per unit observing time compared to space-borne missions. Second because automated scheduling techniques available for ground-based and space-based telescopes are inappropriate for an airborne observatory. Although serious attempts have been made in the past to solve part of the problem, until recently mission operations staff was still manually scheduling flights. We present in this paper a new automated solution for generating SOFIA long-term schedules that will be used in operations from the Cycle 1 observing period. We describe the constraints that should be satisfied to solve the SOFIA scheduling problem in the context of real operations. We establish key formulas required to efficiently calculate the aircraft course over ground when evaluating flight schedules. We describe the foundations of the SOFIA long-term scheduler, the constraint representation, and the random search based algorithm that generates observation and instrument schedules. Finally, we report on how the new long-term scheduler has been used in operations to date.

  18. Issues in Locomotive Crew Management and Scheduling

    DOT National Transportation Integrated Search

    1990-11-01

    This study explores matters related to the scheduling and management of locomotive crews, particularly as they : might contribute to fatigue and stress. It describes how crews are scheduled currently, why there is so much : unpredictability in schedu...

  19. Multiresource allocation and scheduling for periodic soft real-time applications

    NASA Astrophysics Data System (ADS)

    Gopalan, Kartik; Chiueh, Tzi-cker

    2001-12-01

    Real-time applications that utilize multiple system resources, such as CPU, disks, and network links, require coordinated scheduling of these resources in order to meet their end-to-end performance requirements. Most state-of-the-art operating systems support independent resource allocation and deadline-driven scheduling but lack coordination among multiple heterogeneous resources. This paper describes the design and implementation of an Integrated Real-time Resource Scheduler (IRS) that performs coordinated allocation and scheduling of multiple heterogeneous resources on the same machine for periodic soft real-time application. The principal feature of IRS is a heuristic multi-resource allocation algorithm that reserves multiple resources for real-time applications in a manner that can maximize the number of applications admitted into the system in the long run. At run-time, a global scheduler dispatches the tasks of the soft real-time application to individual resource schedulers according to the precedence constraints between tasks. The individual resource schedulers, which could be any deadline based schedulers, can make scheduling decisions locally and yet collectively satisfy a real-time application's performance requirements. The tightness of overall timing guarantees is ultimately determined by the properties of individual resource schedulers. However, IRS maximizes overall system resource utilization efficiency by coordinating deadline assignment across multiple tasks in a soft real-time application.

  20. Escalator: An Autonomous Scheduling Scheme for Convergecast in TSCH

    PubMed Central

    Oh, Sukho; Hwang, DongYeop; Kim, Ki-Hyung; Kim, Kangseok

    2018-01-01

    Time Slotted Channel Hopping (TSCH) is widely used in the industrial wireless sensor networks due to its high reliability and energy efficiency. Various timeslot and channel scheduling schemes have been proposed for achieving high reliability and energy efficiency for TSCH networks. Recently proposed autonomous scheduling schemes provide flexible timeslot scheduling based on the routing topology, but do not take into account the network traffic and packet forwarding delays. In this paper, we propose an autonomous scheduling scheme for convergecast in TSCH networks with RPL as a routing protocol, named Escalator. Escalator generates a consecutive timeslot schedule along the packet forwarding path to minimize the packet transmission delay. The schedule is generated autonomously by utilizing only the local routing topology information without any additional signaling with other nodes. The generated schedule is guaranteed to be conflict-free, in that all nodes in the network could transmit packets to the sink in every slotframe cycle. We implement Escalator and evaluate its performance with existing autonomous scheduling schemes through a testbed and simulation. Experimental results show that the proposed Escalator has lower end-to-end delay and higher packet delivery ratio compared to the existing schemes regardless of the network topology. PMID:29659508

  1. Expert system for on-board satellite scheduling and control

    NASA Technical Reports Server (NTRS)

    Barry, John M.; Sary, Charisse

    1988-01-01

    An Expert System is described which Rockwell Satellite and Space Electronics Division (S&SED) is developing to dynamically schedule the allocation of on-board satellite resources and activities. This expert system is the Satellite Controller. The resources to be scheduled include power, propellant and recording tape. The activities controlled include scheduling satellite functions such as sensor checkout and operation. The scheduling of these resources and activities is presently a labor intensive and time consuming ground operations task. Developing a schedule requires extensive knowledge of the system and subsystems operations, operational constraints, and satellite design and configuration. This scheduling process requires highly trained experts anywhere from several hours to several weeks to accomplish. The process is done through brute force, that is examining cryptic mnemonic data off line to interpret the health and status of the satellite. Then schedules are formulated either as the result of practical operator experience or heuristics - that is rules of thumb. Orbital operations must become more productive in the future to reduce life cycle costs and decrease dependence on ground control. This reduction is required to increase autonomy and survivability of future systems. The design of future satellites require that the scheduling function be transferred from ground to on board systems.

  2. Construction schedules slack time minimizing

    NASA Astrophysics Data System (ADS)

    Krzemiński, Michał

    2017-07-01

    The article presents two copyright models for minimizing downtime working brigades. Models have been developed for construction schedules performed using the method of work uniform. Application of flow shop models is possible and useful for the implementation of large objects, which can be divided into plots. The article also presents a condition describing gives which model should be used, as well as a brief example of optimization schedule. The optimization results confirm the legitimacy of the work on the newly-developed models.

  3. Generically Used Expert Scheduling System (GUESS): User's Guide Version 1.0

    NASA Technical Reports Server (NTRS)

    Liebowitz, Jay; Krishnamurthy, Vijaya; Rodens, Ira

    1996-01-01

    This user's guide contains instructions explaining how to best operate the program GUESS, a generic expert scheduling system. GUESS incorporates several important features for a generic scheduler, including automatic scheduling routines to generate a 'first' schedule for the user, a user interface that includes Gantt charts and enables the human scheduler to manipulate schedules manually, diagnostic report generators, and a variety of scheduling techniques. The current version of GUESS runs on an IBM PC or compatible in the Windows 3.1 or Windows '95 environment.

  4. Long range science scheduling for the Hubble Space Telescope

    NASA Technical Reports Server (NTRS)

    Miller, Glenn; Johnston, Mark

    1991-01-01

    Observations with NASA's Hubble Space Telescope (HST) are scheduled with the assistance of a long-range scheduling system (SPIKE) that was developed using artificial intelligence techniques. In earlier papers, the system architecture and the constraint representation and propagation mechanisms were described. The development of high-level automated scheduling tools, including tools based on constraint satisfaction techniques and neural networks is described. The performance of these tools in scheduling HST observations is discussed.

  5. Research on Production Scheduling System with Bottleneck Based on Multi-agent

    NASA Astrophysics Data System (ADS)

    Zhenqiang, Bao; Weiye, Wang; Peng, Wang; Pan, Quanke

    Aimed at the imbalance problem of resource capacity in Production Scheduling System, this paper uses Production Scheduling System based on multi-agent which has been constructed, and combines the dynamic and autonomous of Agent; the bottleneck problem in the scheduling is solved dynamically. Firstly, this paper uses Bottleneck Resource Agent to find out the bottleneck resource in the production line, analyses the inherent mechanism of bottleneck, and describes the production scheduling process based on bottleneck resource. Bottleneck Decomposition Agent harmonizes the relationship of job's arrival time and transfer time in Bottleneck Resource Agent and Non-Bottleneck Resource Agents, therefore, the dynamic scheduling problem is simplified as the single machine scheduling of each resource which takes part in the scheduling. Finally, the dynamic real-time scheduling problem is effectively solved in Production Scheduling System.

  6. New Scheduling Algorithms for Agile All-Photonic Networks

    NASA Astrophysics Data System (ADS)

    Mehri, Mohammad Saleh; Ghaffarpour Rahbar, Akbar

    2017-12-01

    An optical overlaid star network is a class of agile all-photonic networks that consists of one or more core node(s) at the center of the star network and a number of edge nodes around the core node. In this architecture, a core node may use a scheduling algorithm for transmission of traffic through the network. A core node is responsible for scheduling optical packets that arrive from edge nodes and switching them toward their destinations. Nowadays, most edge nodes use virtual output queue (VOQ) architecture for buffering client packets to achieve high throughput. This paper presents two efficient scheduling algorithms called discretionary iterative matching (DIM) and adaptive DIM. These schedulers find maximum matching in a small number of iterations and provide high throughput and incur low delay. The number of arbiters in these schedulers and the number of messages exchanged between inputs and outputs of a core node are reduced. We show that DIM and adaptive DIM can provide better performance in comparison with iterative round-robin matching with SLIP (iSLIP). SLIP means the act of sliding for a short distance to select one of the requested connections based on the scheduling algorithm.

  7. Block scheduling: Instructional practices in high school science classrooms

    NASA Astrophysics Data System (ADS)

    Richelsoph, Barry

    Proponents of block scheduling perceive this approach to be a 'structural lever' to invite and impel teachers to change their teaching (Marshak, 1997). This desired shift is supposed to be manifest in movement from the traditional classroom structure, focusing on the teacher as lecturer or transmitter of subject matter, to that of teacher as coach with students as active learners, engaged in a variety of activities involving them individually and collaboratively in their education (Canady & Rettig, 1995). Block scheduling changes the formal structure of the school day, but does it really change pedagogical practices in high school science classrooms? Fraser's Individualized Classroom Environment Questionnaire (ICEQ) the instrument used in this study of science classes in five block-scheduled high schools in Connecticut, incorporates the tenets for an enriched classroom environment in its five scales or constructs: Participation---Extent to which students are encouraged to participate rather than be passive learners; Personalization---Emphasis on opportunities for individual students to interact with the teacher and on concern for the personal welfare and social growth of the individual; Investigation---Emphasis on the skills and processes of inquiry and their use in problem solving and investigation. Independence---Extent to which students are allowed to make decisions and have control over their own learning environment and behavior; Differentiation---Emphasis on the selective treatment of students on the basis of ability, learning style, interests, and rate of working (Fraser, 1990). The results and conclusions from this research study suggested that the block-scheduled high school science classes that participated in this research do promote, to varying degrees, those tenets that define an enriched classroom environment. Both the teachers and their classes of students perceived opportunities for Participation, Personalization, and Investigation constructs as

  8. A randomised, double-blind, placebo-controlled, crossover study to assess the efficacy and safety of three dosing schedules of agalsidase alfa enzyme replacement therapy for Fabry disease.

    PubMed

    Hughes, D A; Deegan, P B; Milligan, A; Wright, N; Butler, L H; Jacobs, A; Mehta, A B

    2013-07-01

    Anecdotal reports suggest that the currently approved dosing interval of agalsidase alfa (0.2 mg/kg/2 weeks) for Fabry disease treatment is too long. This randomised, double-blind, placebo-controlled, crossover study investigated three altered dosing intervals. 18 Fabry patients received three agalsidase alfa dosing schedules, each for four weeks (A: 0.2 mg/kg∗2 weeks, B: 0.1 mg/kg/week, C: 0.2 mg/kg/week). Health state, pain levels, sweat volume and latency and plasma and urinary globotriaosylceramide levels were recorded throughout the study. No significant differences were found among the schedules for the primary efficacy outcome of self-assessed health state, or for pain scores. A trend toward increased sweat volume on QSART testing, and reduced urine globotriaosylceramide concentration were seen with treatment schedule C. Agalsidase alfa was safe and well tolerated with all schedules. In conclusion, the primary analyses did not find weekly infusions of agalsidase alfa to be statistically better than the approved dosing schedule however the data indicates that further studies with more patients over a longer period are required to more accurately determine the optimum dose and schedule. Copyright © 2013 Elsevier Inc. All rights reserved.

  9. Techniques for cash management in scheduling manufacturing operations

    NASA Astrophysics Data System (ADS)

    Morady Gohareh, Mehdy; Shams Gharneh, Naser; Ghasemy Yaghin, Reza

    2017-06-01

    The objective in traditional scheduling is usually time based. Minimizing the makespan, total flow times, total tardi costs, etc. are instances of these objectives. In manufacturing, processing each job entails a cost paying and price receiving. Thus, the objective should include some notion of managing the flow of cash. We have defined two new objectives: maximization of average and minimum available cash. For single machine scheduling, it is demonstrated that scheduling jobs in decreasing order of profit ratios maximizes the former and improves productivity. Moreover, scheduling jobs in increasing order of costs and breaking ties in decreasing order of prices maximizes the latter and creates protection against financial instability.

  10. Draft Site Treatment Plan (DSTP), Volumes I and II

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    D`Amelio, J.

    1994-08-30

    Site Treatment Plans (STP) are required for facilities at which the DOE generates or stores mixed waste. This Draft Site Treatment Plan (DSTP) the second step in a three-phase process, identifies the currently preferred options for treating mixed waste at the Savannah River Site (SRS) or for developing treatment technologies where technologies do not exist or need modification. The DSTP reflects site-specific preferred options, developed with the state`s input and based on existing available information. To the extent possible, the DSTP identifies specific treatment facilities for treating the mixed waste and proposes schedules. Where the selection of specific treatment facilitiesmore » is not possible, schedules for alternative activities such as waste characterization and technology assessment are provided. All schedule and cost information presented is preliminary and is subject to change. The DSTP is comprised of two volumes: this Compliance Plan Volume and the Background Volume. This Compliance Plan Volume proposes overall schedules with target dates for achieving compliance with the land disposal restrictions (LDR) of RCRA and procedures for converting the target dates into milestones to be enforced under the Order. The more detailed discussion of the options contained in the Background Volume is provided for informational purposes only.« less

  11. The application of artificial intelligence to astronomical scheduling problems

    NASA Technical Reports Server (NTRS)

    Johnston, Mark D.

    1992-01-01

    Efficient utilization of expensive space- and ground-based observatories is an important goal for the astronomical community; the cost of modern observing facilities is enormous, and the available observing time is much less than the demand from astronomers around the world. The complexity and variety of scheduling constraints and goals has led several groups to investigate how artificial intelligence (AI) techniques might help solve these kinds of problems. The earliest and most successful of these projects was started at Space Telescope Science Institute in 1987 and has led to the development of the Spike scheduling system to support the scheduling of Hubble Space Telescope (HST). The aim of Spike at STScI is to allocate observations to timescales of days to a week observing all scheduling constraints and maximizing preferences that help ensure that observations are made at optimal times. Spike has been in use operationally for HST since shortly after the observatory was launched in Apr. 1990. Although developed specifically for HST scheduling, Spike was carefully designed to provide a general framework for similar (activity-based) scheduling problems. In particular, the tasks to be scheduled are defined in the system in general terms, and no assumptions about the scheduling timescale are built in. The mechanisms for describing, combining, and propagating temporal and other constraints and preferences are quite general. The success of this approach has been demonstrated by the application of Spike to the scheduling of other satellite observatories: changes to the system are required only in the specific constraints that apply, and not in the framework itself. In particular, the Spike framework is sufficiently flexible to handle both long-term and short-term scheduling, on timescales of years down to minutes or less. This talk will discuss recent progress made in scheduling search techniques, the lessons learned from early HST operations, the application of Spike

  12. Sleep and performance in simulated Navy watch schedules.

    PubMed

    Skornyakov, Elena; Shattuck, Nita L; Winser, Michael A; Matsangas, Panagiotis; Sparrow, Amy R; Layton, Matthew E; Gabehart, Rylie J; Van Dongen, Hans P A

    2017-02-01

    To operate Navy ships 24h per day, watchstanding is needed around the clock, with watch periods reflecting a variety of rotating or fixed shift schedules. The 5/15 watch schedule cycles through watch periods with 5h on, 15h off watch, such that watches occur 4h earlier on the clock each day - that is, the watches rotate backward. The timing of sleep varies over 4-day cycles, and sleep is split on some days to accommodate nighttime watchstanding. The 3/9 watch schedule cycles through watch periods with 3h on, 9h off watch, allowing for consistent sleep timing over days. In some sections of the 3/9 watch schedule, sleep may need to be split to accommodate nighttime watchstanding. In both the 5/15 and 3/9 watch schedules, four watch sections alternate to cover the 24h of the day. Here we compared sleep duration, psychomotor vigilance and subjective sleepiness in simulated sections of the 5/15 and 3/9 watch schedules. Fifteen healthy male subjects spent 6 consecutive days (5 nights) in the laboratory. Sleep opportunities were restricted to an average of 6.5h daily. Actigraphically estimated sleep duration was 5.6h per watch day on average, with no significant difference between watch sections. Sleep duration was not reduced when sleep opportunities were split. Psychomotor vigilance degraded over watch days, and tended to be more variable in the 5/15 than in the 3/9 watch sections. These laboratory-based findings suggest that Navy watch schedules are associated with cumulative sleep loss and a build-up of fatigue across days. The fixed watch periods of the 3/9 watch schedule appear to yield more stable performance than the backward rotating watch periods of the 5/15 watch schedule. Optimal performance may require longer and more consistent daily opportunities for sleep than are typically obtained in Navy operations. Copyright © 2015 Elsevier Ltd. All rights reserved.

  13. Cost and schedule estimation study report

    NASA Technical Reports Server (NTRS)

    Condon, Steve; Regardie, Myrna; Stark, Mike; Waligora, Sharon

    1993-01-01

    This report describes the analysis performed and the findings of a study of the software development cost and schedule estimation models used by the Flight Dynamics Division (FDD), Goddard Space Flight Center. The study analyzes typical FDD projects, focusing primarily on those developed since 1982. The study reconfirms the standard SEL effort estimation model that is based on size adjusted for reuse; however, guidelines for the productivity and growth parameters in the baseline effort model have been updated. The study also produced a schedule prediction model based on empirical data that varies depending on application type. Models for the distribution of effort and schedule by life-cycle phase are also presented. Finally, this report explains how to use these models to plan SEL projects.

  14. Designing a fuzzy scheduler for hard real-time systems

    NASA Technical Reports Server (NTRS)

    Yen, John; Lee, Jonathan; Pfluger, Nathan; Natarajan, Swami

    1992-01-01

    In hard real-time systems, tasks have to be performed not only correctly, but also in a timely fashion. If timing constraints are not met, there might be severe consequences. Task scheduling is the most important problem in designing a hard real-time system, because the scheduling algorithm ensures that tasks meet their deadlines. However, the inherent nature of uncertainty in dynamic hard real-time systems increases the problems inherent in scheduling. In an effort to alleviate these problems, we have developed a fuzzy scheduler to facilitate searching for a feasible schedule. A set of fuzzy rules are proposed to guide the search. The situation we are trying to address is the performance of the system when no feasible solution can be found, and therefore, certain tasks will not be executed. We wish to limit the number of important tasks that are not scheduled.

  15. 29 CFR 825.202 - Intermittent leave or reduced leave schedule.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... LABOR OTHER LAWS THE FAMILY AND MEDICAL LEAVE ACT OF 1993 Employee Leave Entitlements Under the Family... leave schedule is a leave schedule that reduces an employee's usual number of working hours per workweek, or hours per workday. A reduced leave schedule is a change in the employee's schedule for a period of...

  16. User interface issues in supporting human-computer integrated scheduling

    NASA Technical Reports Server (NTRS)

    Cooper, Lynne P.; Biefeld, Eric W.

    1991-01-01

    The topics are presented in view graph form and include the following: characteristics of Operations Mission Planner (OMP) schedule domain; OMP architecture; definition of a schedule; user interface dimensions; functional distribution; types of users; interpreting user interaction; dynamic overlays; reactive scheduling; and transitioning the interface.

  17. Education and Social Equity: With a Special Focus on Scheduled Castes and Scheduled Tribes in Elementary Education. CREATE Pathways to Access. Research Monograph No. 19

    ERIC Educational Resources Information Center

    Sedwal, Mona; Kamat, Sangeeta

    2008-01-01

    The Scheduled Castes (SCs, also known as Dalits) and Scheduled Tribes (STs, also known as Adivasis) are among the most socially and educationally disadvantaged groups in India. This paper examines issues concerning school access and equity for Scheduled Caste and Scheduled Tribe communities and also highlights their unique problems, which may…

  18. Scheduling with Automatic Resolution of Conflicts

    NASA Technical Reports Server (NTRS)

    Clement, Bradley; Schaffer, Steve

    2006-01-01

    DSN Requirement Scheduler is a computer program that automatically schedules, reschedules, and resolves conflicts for allocations of resources of NASA s Deep Space Network (DSN) on the basis of ever-changing project requirements for DSN services. As used here, resources signifies, primarily, DSN antennas, ancillary equipment, and times during which they are available. Examples of project-required DSN services include arraying, segmentation, very-long-baseline interferometry, and multiple spacecraft per aperture. Requirements can include periodic reservations of specific or optional resources during specific time intervals or within ranges specified in terms of starting times and durations. This program is built on the Automated Scheduling and Planning Environment (ASPEN) software system (aspects of which have been described in previous NASA Tech Briefs articles), with customization to reflect requirements and constraints involved in allocation of DSN resources. Unlike prior DSN-resource- scheduling programs that make single passes through the requirements and require human intervention to resolve conflicts, this program makes repeated passes in a continuing search for all possible allocations, provides a best-effort solution at any time, and presents alternative solutions among which users can choose.

  19. Car painting process scheduling with harmony search algorithm

    NASA Astrophysics Data System (ADS)

    Syahputra, M. F.; Maiyasya, A.; Purnamawati, S.; Abdullah, D.; Albra, W.; Heikal, M.; Abdurrahman, A.; Khaddafi, M.

    2018-02-01

    Automotive painting program in the process of painting the car body by using robot power, making efficiency in the production system. Production system will be more efficient if pay attention to scheduling of car order which will be done by considering painting body shape of car. Flow shop scheduling is a scheduling model in which the job-job to be processed entirely flows in the same product direction / path. Scheduling problems often arise if there are n jobs to be processed on the machine, which must be specified which must be done first and how to allocate jobs on the machine to obtain a scheduled production process. Harmony Search Algorithm is a metaheuristic optimization algorithm based on music. The algorithm is inspired by observations that lead to music in search of perfect harmony. This musical harmony is in line to find optimal in the optimization process. Based on the tests that have been done, obtained the optimal car sequence with minimum makespan value.

  20. Peer-to-peer Cooperative Scheduling Architecture for National Grid Infrastructure

    NASA Astrophysics Data System (ADS)

    Matyska, Ludek; Ruda, Miroslav; Toth, Simon

    For some ten years, the Czech National Grid Infrastructure MetaCentrum uses a single central PBSPro installation to schedule jobs across the country. This centralized approach keeps a full track about all the clusters, providing support for jobs spanning several sites, implementation for the fair-share policy and better overall control of the grid environment. Despite a steady progress in the increased stability and resilience to intermittent very short network failures, growing number of sites and processors makes this architecture, with a single point of failure and scalability limits, obsolete. As a result, a new scheduling architecture is proposed, which relies on higher autonomy of clusters. It is based on a peer to peer network of semi-independent schedulers for each site or even cluster. Each scheduler accepts jobs for the whole infrastructure, cooperating with other schedulers on implementation of global policies like central job accounting, fair-share, or submission of jobs across several sites. The scheduling system is integrated with the Magrathea system to support scheduling of virtual clusters, including the setup of their internal network, again eventually spanning several sites. On the other hand, each scheduler is local to one of several clusters and is able to directly control and submit jobs to them even if the connection of other scheduling peers is lost. In parallel to the change of the overall architecture, the scheduling system itself is being replaced. Instead of PBSPro, chosen originally for its declared support of large scale distributed environment, the new scheduling architecture is based on the open-source Torque system. The implementation and support for the most desired properties in PBSPro and Torque are discussed and the necessary modifications to Torque to support the MetaCentrum scheduling architecture are presented, too.

  1. Second-order schedules: discrimination of components1

    PubMed Central

    Squires, Nancy; Norborg, James; Fantino, Edmund

    1975-01-01

    Pigeons were exposed to a series of second-order schedules in which the completion of a fixed number of fixed-interval components produced food. In Experiment 1, brief (2 sec) stimulus presentations occurred as each fixed-interval component was completed. During the brief-stimulus presentation terminating the last fixed-interval component, a response was required on a second key, the brief-stimulus key, to produce food. Responses on the brief-stimulus key before the last brief-stimulus presentation had no scheduled consequences, but served as a measure of the extent to which the final component was discriminated from preceding components. Whether there were one, two, four, or eight fixed-interval components, responses on the brief-stimulus key occurred during virtually every brief-stimulus presentation. In Experiment 2, an attempt was made to punish unnecessary responses on the brief-stimulus key, i.e., responses on the brief-stimulus key that occurred before the last component. None of the pigeons learned to withhold these responses, even though they produced a 15-sec timeout and loss of primary reinforcement. In Experiment 3, different key colors were associated with each component of a second-order schedule (a chain schedule). In contrast to Experiment 1, brief-stimulus key responses were confined to the last component. It was concluded that pigeons do not discriminate well between components of second-order schedules unless a unique exteroceptive cue is provided for each component. The relative discriminability of the components may account for the observed differences in initial-component response rates between comparable brief-stimulus, tandem, and chain schedules. PMID:16811868

  2. 15 CFR 712.4 - New Schedule 1 production facility.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE CHEMICAL WEAPONS CONVENTION REGULATIONS ACTIVITIES INVOLVING SCHEDULE 1 CHEMICALS § 712.4 New Schedule 1 production facility. (a) Establishment of a...) of the CWCR, and you intend to begin production of Schedule 1 chemicals at your facility in...

  3. 5 CFR 532.513 - Flexible and compressed work schedules.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Flexible and compressed work schedules... REGULATIONS PREVAILING RATE SYSTEMS Premium Pay and Differentials § 532.513 Flexible and compressed work schedules. Federal Wage System employees who are authorized to work flexible and compressed work schedules...

  4. 15 CFR 712.4 - New Schedule 1 production facility.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE CHEMICAL WEAPONS CONVENTION REGULATIONS ACTIVITIES INVOLVING SCHEDULE 1 CHEMICALS § 712.4 New Schedule 1 production facility. (a) Establishment of a...) of the CWCR, and you intend to begin production of Schedule 1 chemicals at your facility in...

  5. Improved Scheduling Mechanisms for Synchronous Information and Energy Transmission.

    PubMed

    Qin, Danyang; Yang, Songxiang; Zhang, Yan; Ma, Jingya; Ding, Qun

    2017-06-09

    Wireless energy collecting technology can effectively reduce the network time overhead and prolong the wireless sensor network (WSN) lifetime. However, the traditional energy collecting technology cannot achieve the balance between ergodic channel capacity and average collected energy. In order to solve the problem of the network transmission efficiency and the limited energy of wireless devices, three improved scheduling mechanisms are proposed: improved signal noise ratio (SNR) scheduling mechanism (IS2M), improved N-SNR scheduling mechanism (INS2M) and an improved Equal Throughput scheduling mechanism (IETSM) for different channel conditions to improve the whole network performance. Meanwhile, the average collected energy of single users and the ergodic channel capacity of three scheduling mechanisms can be obtained through the order statistical theory in Rayleig, Ricean, Nakagami- m and Weibull fading channels. It is concluded that the proposed scheduling mechanisms can achieve better balance between energy collection and data transmission, so as to provide a new solution to realize synchronous information and energy transmission for WSNs.

  6. ESSOPE: Towards S/C operations with reactive schedule planning

    NASA Technical Reports Server (NTRS)

    Wheadon, J.

    1993-01-01

    The ESSOPE is a prototype front-end tool running on a Sun workstation and interfacing to ESOC's MSSS spacecraft control system for the exchange of telecommand requests (to MSSS) and telemetry reports (from MSSS). ESSOPE combines an operations Planner-Scheduler, with a Schedule Execution Control function. Using an internal 'model' of the spacecraft, the Planner generates a schedule based on utilization requests for a variety of payload services by a community of Olympus users, and incorporating certain housekeeping operations. Conflicts based on operational constraints are automatically resolved, by employing one of several available strategies. The schedule is passed to the execution function which drives MSSS to perform it. When the schedule can no longer be met, either because the operator interferes (by delays or changes of requirements), or because ESSOPE has recognized some spacecraft anomalies, the Planner produces a modified schedule maintaining the on-going procedures as far as consistent with the new constraints or requirements.

  7. Improved Scheduling Mechanisms for Synchronous Information and Energy Transmission

    PubMed Central

    Qin, Danyang; Yang, Songxiang; Zhang, Yan; Ma, Jingya; Ding, Qun

    2017-01-01

    Wireless energy collecting technology can effectively reduce the network time overhead and prolong the wireless sensor network (WSN) lifetime. However, the traditional energy collecting technology cannot achieve the balance between ergodic channel capacity and average collected energy. In order to solve the problem of the network transmission efficiency and the limited energy of wireless devices, three improved scheduling mechanisms are proposed: improved signal noise ratio (SNR) scheduling mechanism (IS2M), improved N-SNR scheduling mechanism (INS2M) and an improved Equal Throughput scheduling mechanism (IETSM) for different channel conditions to improve the whole network performance. Meanwhile, the average collected energy of single users and the ergodic channel capacity of three scheduling mechanisms can be obtained through the order statistical theory in Rayleig, Ricean, Nakagami-m and Weibull fading channels. It is concluded that the proposed scheduling mechanisms can achieve better balance between energy collection and data transmission, so as to provide a new solution to realize synchronous information and energy transmission for WSNs. PMID:28598395

  8. Future Air Traffic Growth and Schedule Model User's Guide

    NASA Technical Reports Server (NTRS)

    Kimmel, William M. (Technical Monitor); Smith, Jeremy C.; Dollyhigh, Samuel M.

    2004-01-01

    The Future Air Traffic Growth and Schedule Model was developed as an implementation of the Fratar algorithm to project future traffic flow between airports in a system and of then scheduling the additional flights to reflect current passenger time-of-travel preferences. The methodology produces an unconstrained future schedule from a current (or baseline) schedule and the airport operations growth rates. As an example of the use of the model, future schedules are projected for 2010 and 2022 for all flights arriving at, departing from, or flying between all continental United States airports that had commercial scheduled service for May 17, 2002. Inter-continental US traffic and airports are included and the traffic is also grown with the Fratar methodology to account for their arrivals and departures to the continental US airports. Input data sets derived from the Official Airline Guide (OAG) data and FAA Terminal Area Forecast (TAF) are included in the examples of the computer code execution.

  9. Predit: A temporal predictive framework for scheduling systems

    NASA Technical Reports Server (NTRS)

    Paolucci, E.; Patriarca, E.; Sem, M.; Gini, G.

    1992-01-01

    Scheduling can be formalized as a Constraint Satisfaction Problem (CSP). Within this framework activities belonging to a plan are interconnected via temporal constraints that account for slack among them. Temporal representation must include methods for constraints propagation and provide a logic for symbolic and numerical deductions. In this paper we describe a support framework for opportunistic reasoning in constraint directed scheduling. In order to focus the attention of an incremental scheduler on critical problem aspects, some discrete temporal indexes are presented. They are also useful for the prediction of the degree of resources contention. The predictive method expressed through our indexes can be seen as a Knowledge Source for an opportunistic scheduler with a blackboard architecture.

  10. Effect of sampling schedule on pharmacokinetic parameter estimates of promethazine in astronauts

    NASA Astrophysics Data System (ADS)

    Boyd, Jason L.; Wang, Zuwei; Putcha, Lakshmi

    2005-08-01

    Six astronauts on the Shuttle Transport System (STS) participated in an investigation on the pharmacokinetics of promethazine (PMZ), a medication used for the treatment of space motion sickness (SMS) during flight. Each crewmember completed the protocol once during flight and repeated thirty days after returned to Earth. Saliva samples were collected at scheduled times for 72 h after PMZ administration; more frequent samples were collected on the ground than during flight owing to schedule constraints in flight. PMZ concentrations in saliva were determined by a liquid chromatographic/mass spectrometric (LC-MS) assay and pharmacokinetic parameters (PKPs) were calculated using actual flight and ground-based data sets and using time-matched sampling schedule on ground to that during flight. Volume of distribution (Vc) and clearance (Cls) decreased during flight compared to that from time-matched ground data set; however, ClS and Vc estimates were higher for all subjects when partial ground data sets were used for analysis. Area under the curve (AUC) normalized with administered dose was similar in flight and partial ground data; however AUC was significantly lower using time-matched sampling compared with the full data set on ground. Half life (t1/2) was longest during flight, shorter with matched-sampling schedule on ground and shortest when complete data set from ground was used. Maximum concentration (Cmax), time for Cmax (tmax), parameters of drug absorption, depicted a similar trend with lowest and longest respectively, during flight, lower with time- matched ground data and highest and shortest with full ground data.

  11. 28 CFR 548.13 - Schedules and facilities.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 28 Judicial Administration 2 2011-07-01 2011-07-01 false Schedules and facilities. 548.13 Section 548.13 Judicial Administration BUREAU OF PRISONS, DEPARTMENT OF JUSTICE INSTITUTIONAL MANAGEMENT RELIGIOUS PROGRAMS Religious Beliefs and Practices of Committed Offenders § 548.13 Schedules and facilities...

  12. 28 CFR 548.13 - Schedules and facilities.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Schedules and facilities. 548.13 Section 548.13 Judicial Administration BUREAU OF PRISONS, DEPARTMENT OF JUSTICE INSTITUTIONAL MANAGEMENT RELIGIOUS PROGRAMS Religious Beliefs and Practices of Committed Offenders § 548.13 Schedules and facilities...

  13. 28 CFR 548.13 - Schedules and facilities.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 28 Judicial Administration 2 2014-07-01 2014-07-01 false Schedules and facilities. 548.13 Section 548.13 Judicial Administration BUREAU OF PRISONS, DEPARTMENT OF JUSTICE INSTITUTIONAL MANAGEMENT RELIGIOUS PROGRAMS Religious Beliefs and Practices of Committed Offenders § 548.13 Schedules and facilities...

  14. 28 CFR 548.13 - Schedules and facilities.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 28 Judicial Administration 2 2012-07-01 2012-07-01 false Schedules and facilities. 548.13 Section 548.13 Judicial Administration BUREAU OF PRISONS, DEPARTMENT OF JUSTICE INSTITUTIONAL MANAGEMENT RELIGIOUS PROGRAMS Religious Beliefs and Practices of Committed Offenders § 548.13 Schedules and facilities...

  15. 28 CFR 548.13 - Schedules and facilities.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 28 Judicial Administration 2 2013-07-01 2013-07-01 false Schedules and facilities. 548.13 Section 548.13 Judicial Administration BUREAU OF PRISONS, DEPARTMENT OF JUSTICE INSTITUTIONAL MANAGEMENT RELIGIOUS PROGRAMS Religious Beliefs and Practices of Committed Offenders § 548.13 Schedules and facilities...

  16. 8 CFR 1003.18 - Scheduling of cases.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ....18 Aliens and Nationality EXECUTIVE OFFICE FOR IMMIGRATION REVIEW, DEPARTMENT OF JUSTICE GENERAL PROVISIONS EXECUTIVE OFFICE FOR IMMIGRATION REVIEW Immigration Court-Rules of Procedure § 1003.18 Scheduling of cases. (a) The Immigration Court shall be responsible for scheduling cases and providing notice to...

  17. Automated Scheduling of Science Activities for Titan Encounters by Cassini

    NASA Technical Reports Server (NTRS)

    Ray, Trina L.; Knight, Russel L.; Mohr, Dave

    2014-01-01

    In an effort to demonstrate the efficacy of automated planning and scheduling techniques for large missions, we have adapted ASPEN (Activity Scheduling and Planning Environment) [1] and CLASP (Compressed Large-scale Activity Scheduling and Planning) [2] to the domain of scheduling high-level science goals into conflict-free operations plans for Titan encounters by the Cassini spacecraft.

  18. An Experimental Study of Scheduling and Duration of "Tier 2" First-Grade Reading Intervention

    ERIC Educational Resources Information Center

    Denton, Carolyn A.; Cirino, Paul T.; Barth, Amy E.; Romain, Melissa; Vaughn, Sharon; Wexler, Jade; Francis, David J.; Fletcher, Jack M.

    2011-01-01

    This study compared the effects on reading outcomes of delivering supplemental, small-group intervention to first-grade students at risk for reading difficulties randomly assigned to one of three different treatment schedules: extended (4 sessions per week, 16 weeks; n = 66), concentrated (4 sessions per week, 8 weeks; n = 64), or distributed (2…

  19. Bridging the Gap Between Planning and Scheduling

    NASA Technical Reports Server (NTRS)

    Smith, David E.; Frank, Jeremy; Jonsson, Ari K.; Norvig, Peter (Technical Monitor)

    2000-01-01

    Planning research in Artificial Intelligence (AI) has often focused on problems where there are cascading levels of action choice and complex interactions between actions. In contrast. Scheduling research has focused on much larger problems where there is little action choice, but the resulting ordering problem is hard. In this paper, we give an overview of M planning and scheduling techniques, focusing on their similarities, differences, and limitations. We also argue that many difficult practical problems lie somewhere between planning and scheduling, and that neither area has the right set of tools for solving these vexing problems.

  20. Scheduling Operations for Massive Heterogeneous Clusters

    NASA Technical Reports Server (NTRS)

    Humphrey, John; Spagnoli, Kyle

    2013-01-01

    High-performance computing (HPC) programming has become increasingly difficult with the advent of hybrid supercomputers consisting of multicore CPUs and accelerator boards such as the GPU. Manual tuning of software to achieve high performance on this type of machine has been performed by programmers. This is needlessly difficult and prone to being invalidated by new hardware, new software, or changes in the underlying code. A system was developed for task-based representation of programs, which when coupled with a scheduler and runtime system, allows for many benefits, including higher performance and utilization of computational resources, easier programming and porting, and adaptations of code during runtime. The system consists of a method of representing computer algorithms as a series of data-dependent tasks. The series forms a graph, which can be scheduled for execution on many nodes of a supercomputer efficiently by a computer algorithm. The schedule is executed by a dispatch component, which is tailored to understand all of the hardware types that may be available within the system. The scheduler is informed by a cluster mapping tool, which generates a topology of available resources and their strengths and communication costs. Software is decoupled from its hardware, which aids in porting to future architectures. A computer algorithm schedules all operations, which for systems of high complexity (i.e., most NASA codes), cannot be performed optimally by a human. The system aids in reducing repetitive code, such as communication code, and aids in the reduction of redundant code across projects. It adds new features to code automatically, such as recovering from a lost node or the ability to modify the code while running. In this project, the innovators at the time of this reporting intend to develop two distinct technologies that build upon each other and both of which serve as building blocks for more efficient HPC usage. First is the scheduling and dynamic

  1. Student Scheduling Choices and Time to Completion of a Two-Year Credential

    ERIC Educational Resources Information Center

    Rzeznik, Mark A.

    2017-01-01

    All students need to decide how to schedule their classes to complete their credential. This study examined three types of student scheduling choices: full-block scheduling, partial-block scheduling, and traditional scheduling to address two research questions: How do the choices students make in scheduling classes-using three scheduling…

  2. Factors Associated With Pediatrician Responses to Alternative Immunization Schedule Requests.

    PubMed

    Mohanty, Salini; Feemster, Kristen A; Buttenheim, Alison; Moser, Charlotte A; Field, Robert I; Mayer, Whitney; Carroll-Scott, Amy

    2018-02-01

    We conducted a cross-sectional online survey among 4 chapters of the American Academy of Pediatrics from July through October 2014 to describe characteristics of pediatricians and practices associated with practice-level responses to alternative immunization schedule requests. Among 374 pediatricians, 58% reported frequent alternative immunization schedule requests and 24% reported feeling comfortable using them. Pediatricians who work in practices that accommodate alternative immunization schedule requests have increased odds of having a high frequency of alternative immunization schedule requests, and beliefs that relationships with families would be negatively affected if they refused requests. Practices that discontinue care to families who request alternative immunization schedules have increased odds of being a private group practice and having a formal office vaccine policy. Pediatricians are frequently asked to use alternative immunization schedules and many are not comfortable using them. Practice-level responses to alternative immunization schedules are associated with characteristics of pediatricians and practices.

  3. Intermittent Metronomic Drug Schedule Is Essential for Activating Antitumor Innate Immunity and Tumor Xenograft Regression12

    PubMed Central

    Chen, Chong-Sheng; Doloff, Joshua C; Waxman, David J

    2014-01-01

    Metronomic chemotherapy using cyclophosphamide (CPA) is widely associated with antiangiogenesis; however, recent studies implicate other immune-based mechanisms, including antitumor innate immunity, which can induce major tumor regression in implanted brain tumor models. This study demonstrates the critical importance of drug schedule: CPA induced a potent antitumor innate immune response and tumor regression when administered intermittently on a 6-day repeating metronomic schedule but not with the same total exposure to activated CPA administered on an every 3-day schedule or using a daily oral regimen that serves as the basis for many clinical trials of metronomic chemotherapy. Notably, the more frequent metronomic CPA schedules abrogated the antitumor innate immune and therapeutic responses. Further, the innate immune response and antitumor activity both displayed an unusually steep dose-response curve and were not accompanied by antiangiogenesis. The strong recruitment of innate immune cells by the 6-day repeating CPA schedule was not sustained, and tumor regression was abolished, by a moderate (25%) reduction in CPA dose. Moreover, an ∼20% increase in CPA dose eliminated the partial tumor regression and weak innate immune cell recruitment seen in a subset of the every 6-day treated tumors. Thus, metronomic drug treatment must be at a sufficiently high dose but also sufficiently well spaced in time to induce strong sustained antitumor immune cell recruitment. Many current clinical metronomic chemotherapeutic protocols employ oral daily low-dose schedules that do not meet these requirements, suggesting that they may benefit from optimization designed to maximize antitumor immune responses. PMID:24563621

  4. CRI planning and scheduling for space

    NASA Technical Reports Server (NTRS)

    Aarup, Mads

    1994-01-01

    Computer Resources International (CRI) has many years of experience in developing space planning and scheduling systems for the European Space Agency. Activities range from AIT/AIV planning over mission planning to research in on-board autonomy using advanced planning and scheduling technologies in conjunction with model based diagnostics. This article presents four projects carried out for ESA by CRI with various subcontractors: (1) DI, Distributed Intelligence for Ground/Space Systems is an on-going research project; (2) GMPT, Generic Mission Planning Toolset, a feasibility study concluded in 1993; (3) OPTIMUM-AIV, Open Planning Tool for AIV, development of a knowledge based AIV planning and scheduling tool ended in 1992; and (4) PlanERS-1, development of an AI and knowledge-based mission planning prototype for the ERS-1 earth observation spacecraft ended in 1991.

  5. Deep Space Network Scheduling Using Evolutionary Computational Methods

    NASA Technical Reports Server (NTRS)

    Guillaume, Alexandre; Lee, Seugnwon; Wang, Yeou-Fang; Terrile, Richard J.

    2007-01-01

    The paper presents the specific approach taken to formulate the problem in terms of gene encoding, fitness function, and genetic operations. The genome is encoded such that a subset of the scheduling constraints is automatically satisfied. Several fitness functions are formulated to emphasize different aspects of the scheduling problem. The optimal solutions of the different fitness functions demonstrate the trade-off of the scheduling problem and provide insight into a conflict resolution process.

  6. 48 CFR 1371.104 - Schedule of work.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Schedule of work. 1371.104 Section 1371.104 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE DEPARTMENT SUPPLEMENTAL... of work. Insert clause 1352.271-73, Schedule of Work, in all solicitations and contracts for ship...

  7. 20 CFR 614.12 - Schedules of remuneration.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Schedules of remuneration. 614.12 Section 614.12 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR UNEMPLOYMENT... Forces, with a statement of the effective date of the schedule. Benefit amounts for the UCX Program are...

  8. 77 FR 11599 - January 2012 Pay Schedules

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-27

    ... OFFICE OF PERSONNEL MANAGEMENT January 2012 Pay Schedules AGENCY: U.S. Office of Personnel Management. ACTION: Notice. SUMMARY: The President has signed an Executive order containing the 2012 pay schedules for certain Federal civilian employees. The rates of pay for these employees will not be increased...

  9. 76 FR 18262 - January 2011 Pay Schedules

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-01

    ... OFFICE OF PERSONNEL MANAGEMENT January 2011 Pay Schedules AGENCY: U.S. Office of Personnel... civilian employee pay schedules are not adjusted in 2011 and remain at 2010 levels. This notice serves as documentation for the public record. FOR FURTHER INFORMATION CONTACT: Lisa Dismond, Pay and Leave, Employee...

  10. Safety and Immunogenicity of Sequential Rotavirus Vaccine Schedules

    PubMed Central

    Libster, Romina; McNeal, Monica; Walter, Emmanuel B.; Shane, Andi L.; Winokur, Patricia; Cress, Gretchen; Berry, Andrea A.; Kotloff, Karen L.; Sarpong, Kwabena; Turley, Christine B.; Harrison, Christopher J.; Pahud, Barbara A.; Marbin, Jyothi; Dunn, John; El-Khorazaty, Jill; Barrett, Jill

    2016-01-01

    BACKGROUND AND OBJECTIVES: Although both licensed rotavirus vaccines are safe and effective, it is often not possible to complete the schedule by using the same vaccine formulation. The goal of this study was to investigate the noninferiority of the immune responses to the 2 licensed rotavirus vaccines when administered as a mixed schedule compared with administering a single vaccine formulation alone. METHODS: Randomized, multicenter, open-label study. Healthy infants (6–14 weeks of age) were randomized to receive rotavirus vaccines in 1 of 5 different schedules (2 using a single vaccine for all doses, and 3 using mixed schedules). The group receiving only the monovalent rotavirus vaccine received 2 doses of vaccine and the other 4 groups received 3 doses of vaccine. Serum for immunogenicity testing was obtained 1 month after the last vaccine dose and the proportion of seropositive children (rotavirus immunoglobulin A ≥20 U/mL) were compared in all the vaccine groups. RESULTS: Between March 2011 and September 2013, 1393 children were enrolled and randomized. Immune responses to all the sequential mixed vaccine schedules were shown to be noninferior when compared with the 2 single vaccine reference groups. The proportion of children seropositive to at least 1 vaccine antigen at 1 month after vaccination ranged from 77% to 96%, and was not significantly different among all the study groups. All schedules were well tolerated. CONCLUSIONS: Mixed schedules are safe and induced comparable immune responses when compared with the licensed rotavirus vaccines given alone. PMID:26823540

  11. Fixed-Time Schedule Effects in Combination with Response-Dependent Schedules

    ERIC Educational Resources Information Center

    Borrero, John C.; Bartels-Meints, Jamie A.; Sy, Jolene R.; Francisco, Monica T.

    2011-01-01

    We evaluated the effects of fixed-interval (FI), fixed-time (FT), and conjoint (combined) FI FT reinforcement schedules on the responding of 3 adults who had been diagnosed with schizophrenia. Responding on vocational tasks decreased for 2 of 3 participants under FT alone relative to FI alone. Responding under FI FT resulted in response…

  12. 48 CFR 852.236-84 - Schedule of work progress.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Schedule of work progress... Schedule of work progress. As prescribed in 836.575, insert the following clause: Schedule of Work Progress... indicates the anticipated installation of work versus the elapsed contract time, for the approval of the...

  13. 10 CFR 2.332 - General case scheduling and management.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false General case scheduling and management. 2.332 Section 2... Management for NRC Adjudicatory Hearings § 2.332 General case scheduling and management. (a) Scheduling order... the issues presented, relevant considerations which a party may bring to the attention of the...

  14. Cure Schedule for Stycast 2651/Catalyst 11.

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kropka, Jamie Michael; McCoy, John D.

    2017-11-01

    The Henkel technical data sheet (TDS) for Stycast 2651/Catalyst 11 lists three alternate cure schedules for the material, each of which would result in a different state of reaction and different material properties. Here, a cure schedule that attains full reaction of the material is defined. The use of this cure schedule will eliminate variance in material properties due to changes in the cure state of the material, and the cure schedule will serve as the method to make material prior to characterizing properties. The following recommendation was motivated by (1) a desire to cure at a single temperature formore » ease of manufacture and (2) a desire to keep the cure temperature low (to minimize residual stress build-up associated with the cooldown from the cure temperature to room temperature) without excessively limiting the cure reaction due to vitrification (i.e., material glass transition temperature, T g, exceeding cure temperature).« less

  15. Evaluation of Scheduling Methods for Multiple Runways

    NASA Technical Reports Server (NTRS)

    Bolender, Michael A.; Slater, G. L.

    1996-01-01

    Several scheduling strategies are analyzed in order to determine the most efficient means of scheduling aircraft when multiple runways are operational and the airport is operating at different utilization rates. The study compares simulation data for two and three runway scenarios to results from queuing theory for an M/D/n queue. The direction taken, however, is not to do a steady-state, or equilibrium, analysis since this is not the case during a rush period at a typical airport. Instead, a transient analysis of the delay per aircraft is performed. It is shown that the scheduling strategy that reduces the delay depends upon the density of the arrival traffic. For light traffic, scheduling aircraft to their preferred runways is sufficient; however, as the arrival rate increases, it becomes more important to separate traffic by weight class. Significant delay reduction is realized when aircraft that belong to the heavy and small weight classes are sent to separate runways with large aircraft put into the 'best' landing slot.

  16. Job Scheduling in a Heterogeneous Grid Environment

    NASA Technical Reports Server (NTRS)

    Shan, Hong-Zhang; Smith, Warren; Oliker, Leonid; Biswas, Rupak

    2004-01-01

    Computational grids have the potential for solving large-scale scientific problems using heterogeneous and geographically distributed resources. However, a number of major technical hurdles must be overcome before this potential can be realized. One problem that is critical to effective utilization of computational grids is the efficient scheduling of jobs. This work addresses this problem by describing and evaluating a grid scheduling architecture and three job migration algorithms. The architecture is scalable and does not assume control of local site resources. The job migration policies use the availability and performance of computer systems, the network bandwidth available between systems, and the volume of input and output data associated with each job. An extensive performance comparison is presented using real workloads from leading computational centers. The results, based on several key metrics, demonstrate that the performance of our distributed migration algorithms is significantly greater than that of a local scheduling framework and comparable to a non-scalable global scheduling approach.

  17. Individualized Learning through Computerized Modular Scheduling, Second Report of Scheduling Project at Virgin Valley High School, Mesquite, Nevada.

    ERIC Educational Resources Information Center

    Allan, Blaine W.

    In 1963 Stanford University selected Virgin Valley High School in southern Nevada as one of four pilot schools to use computerized modular scheduling. Schedules for 165 students and assignments for 14 teachers were developed at the Stanford University Computer Computation Center using 30-minute modules with a total of 80 modules per week. After…

  18. Artificial intelligence for the CTA Observatory scheduler

    NASA Astrophysics Data System (ADS)

    Colomé, Josep; Colomer, Pau; Campreciós, Jordi; Coiffard, Thierry; de Oña, Emma; Pedaletti, Giovanna; Torres, Diego F.; Garcia-Piquer, Alvaro

    2014-08-01

    The Cherenkov Telescope Array (CTA) project will be the next generation ground-based very high energy gamma-ray instrument. The success of the precursor projects (i.e., HESS, MAGIC, VERITAS) motivated the construction of this large infrastructure that is included in the roadmap of the ESFRI projects since 2008. CTA is planned to start the construction phase in 2015 and will consist of two arrays of Cherenkov telescopes operated as a proposal-driven open observatory. Two sites are foreseen at the southern and northern hemispheres. The CTA observatory will handle several observation modes and will have to operate tens of telescopes with a highly efficient and reliable control. Thus, the CTA planning tool is a key element in the control layer for the optimization of the observatory time. The main purpose of the scheduler for CTA is the allocation of multiple tasks to one single array or to multiple sub-arrays of telescopes, while maximizing the scientific return of the facility and minimizing the operational costs. The scheduler considers long- and short-term varying conditions to optimize the prioritization of tasks. A short-term scheduler provides the system with the capability to adapt, in almost real-time, the selected task to the varying execution constraints (i.e., Targets of Opportunity, health or status of the system components, environment conditions). The scheduling procedure ensures that long-term planning decisions are correctly transferred to the short-term prioritization process for a suitable selection of the next task to execute on the array. In this contribution we present the constraints to CTA task scheduling that helped classifying it as a Flexible Job-Shop Problem case and finding its optimal solution based on Artificial Intelligence techniques. We describe the scheduler prototype that uses a Guarded Discrete Stochastic Neural Network (GDSN), for an easy representation of the possible long- and short-term planning solutions, and Constraint

  19. Automated Scheduling of Personnel to Staff Operations for the Mars Science Laboratory

    NASA Technical Reports Server (NTRS)

    Knight, Russell; Mishkin, Andrew; Allbaugh, Alicia

    2014-01-01

    Leveraging previous work on scheduling personnel for space mission operations, we have adapted ASPEN (Activity Scheduling and Planning Environment) [1] to the domain of scheduling personnel for operations of the Mars Science Laboratory. Automated scheduling of personnel is not new. We compare our representations to a sampling of employee scheduling systems available with respect to desired features. We described the constraints required by MSL personnel schedulers and how each is handled by the scheduling algorithm.

  20. Efficacy of melatonin with behavioural sleep-wake scheduling for delayed sleep-wake phase disorder: A double-blind, randomised clinical trial.

    PubMed

    Sletten, Tracey L; Magee, Michelle; Murray, Jade M; Gordon, Christopher J; Lovato, Nicole; Kennaway, David J; Gwini, Stella M; Bartlett, Delwyn J; Lockley, Steven W; Lack, Leon C; Grunstein, Ronald R; Rajaratnam, Shantha M W

    2018-06-01

    Delayed Sleep-Wake Phase Disorder (DSWPD) is characterised by sleep initiation insomnia when attempting sleep at conventional times and difficulty waking at the required time for daytime commitments. Although there are published therapeutic guidelines for the administration of melatonin for DSWPD, to our knowledge, randomised controlled trials are lacking. This trial tested the efficacy of 0.5 mg melatonin, combined with behavioural sleep-wake scheduling, for improving sleep initiation in clinically diagnosed DSWPD patients with a delayed endogenous melatonin rhythm relative to patient-desired (or -required) bedtime (DBT). This randomised, placebo-controlled, double-blind clinical trial was conducted in an Australian outpatient DSWPD population. Following 1-wk baseline, clinically diagnosed DSWPD patients with delayed melatonin rhythm relative to DBT (salivary dim light melatonin onset [DLMO] after or within 30 min before DBT) were randomised to 4-wk treatment with 0.5 mg fast-release melatonin or placebo 1 h before DBT for at least 5 consecutive nights per week. All patients received behavioural sleep-wake scheduling, consisting of bedtime scheduled at DBT. The primary outcome was actigraphic sleep onset time. Secondary outcomes were sleep efficiency in the first third of time in bed (SE T1) on treatment nights, subjective sleep-related daytime impairment (Patient Reported Outcomes Measurement Information System [PROMIS]), PROMIS sleep disturbance, measures of daytime sleepiness, clinician-rated change in illness severity, and DLMO time. Between September 13, 2012 and September 1, 2014, 307 participants were registered; 116 were randomised to treatment (intention-to-treat n = 116; n = 62 males; mean age, 29.0 y). Relative to baseline and compared to placebo, sleep onset occurred 34 min earlier (95% confidence interval [CI] -60 to -8) in the melatonin group. SE T1 increased; PROMIS sleep-related impairment, PROMIS sleep disturbance, insomnia severity, and