High-quality regional gravity field determination from GOCE gravity gradient and heterogeneous gravimetry and altimetry data

NASA Astrophysics Data System (ADS)

Wu, Y.; Luo, Z.; Zhou, H.; Xu, C.

2017-12-01

Regional gravity field recovery is of great importance for understanding ocean circulation and currents in oceanography and investigating the structure of the lithosphere in geophysics. Under the framework of remove-compute-restore methodology (RCR), a regional approach using spherical radial basis functions (SRBFs) is set up for gravity field determination using the GOCE (Gravity Field and Steady-State Ocean Circulation Explorer) gravity gradient tensor, heterogeneous gravimetry and altimetry measurements. The additional value on regional model introduced by GOCE data is validated and quantified. Numerical experiments in a western European region show that the effects introduced by GOCE data display as long-wavelength patterns on the centimeter scale in terms of quasi-geoid heights, which may allow to highlight and reduce the remaining long-wavelength errors and biases in ground-based data and improve the regional model. The accuracy of the gravimetric quasi-geoid computed with a combination of three diagonal components is improved by 0.6 cm (0.5 cm) in the Netherlands (Belgium), compared to that derived from gravimetry and altimetry data alone, when GOCO05s is used as the reference model. Performances of different diagonal components and their combinations are not identical; the solution with vertical gradients shows highest quality when a single component is used. Incorporation of multiple components further improves the model, and the combination of three components shows the best fit to GPS/leveling data. Moreover, the contributions introduced by different components are heterogeneous in terms of spatial coverage and magnitude, although similar structures occur in the spatial domain. Contributions introduced by the vertical components have the most significant effects when a single component is applied. Combination of multiple components further magnifies these effects and improves the solutions, and the incorporation of three components has the most prominent effects. This work is supported by the State Scholarship Fund from Chinese Scholarship Council (201306270014), China Postdoctoral Science Foundation (No.2016M602301), and the National Natural Science Foundation of China (No. 41374023).

Optimal Geoid Modelling to determine the Mean Ocean Circulation - Project Overview and early Results

NASA Astrophysics Data System (ADS)

Fecher, Thomas; Knudsen, Per; Bettadpur, Srinivas; Gruber, Thomas; Maximenko, Nikolai; Pie, Nadege; Siegismund, Frank; Stammer, Detlef

2017-04-01

The ESA project GOCE-OGMOC (Optimal Geoid Modelling based on GOCE and GRACE third-party mission data and merging with altimetric sea surface data to optimally determine Ocean Circulation) examines the influence of the satellite missions GRACE and in particular GOCE in ocean modelling applications. The project goal is an improved processing of satellite and ground data for the preparation and combination of gravity and altimetry data on the way to an optimal MDT solution. Explicitly, the two main objectives are (i) to enhance the GRACE error modelling and optimally combine GOCE and GRACE [and optionally terrestrial/altimetric data] and (ii) to integrate the optimal Earth gravity field model with MSS and drifter information to derive a state-of-the art MDT including an error assessment. The main work packages referring to (i) are the characterization of geoid model errors, the identification of GRACE error sources, the revision of GRACE error models, the optimization of weighting schemes for the participating data sets and finally the estimation of an optimally combined gravity field model. In this context, also the leakage of terrestrial data into coastal regions shall be investigated, as leakage is not only a problem for the gravity field model itself, but is also mirrored in a derived MDT solution. Related to (ii) the tasks are the revision of MSS error covariances, the assessment of the mean circulation using drifter data sets and the computation of an optimal geodetic MDT as well as a so called state-of-the-art MDT, which combines the geodetic MDT with drifter mean circulation data. This paper presents an overview over the project results with focus on the geodetic results part.

Intercontinental height datum connection with GOCE and GPS-levelling data

NASA Astrophysics Data System (ADS)

Gruber, T.; Gerlach, C.; Haagmans, R.

2012-12-01

In this study an attempt is made to establish height system datum connections based upon a gravity field and steady-state ocean circulation explorer (GOCE) gravity field model and a set of global positioning system (GPS) and levelling data. The procedure applied in principle is straightforward. First local geoid heights are obtained point wise from GPS and levelling data. Then the mean of these geoid heights is computed for regions nominally referring to the same height datum. Subsequently, these local mean geoid heights are compared with a mean global geoid from GOCE for the same region. This way one can identify an offset of the local to the global geoid per region. This procedure is applied to a number of regions distributed worldwide. Results show that the vertical datum offset estimates strongly depend on the nature of the omission error, i.e. the signal not represented in the GOCE model. For a smooth gravity field the commission error of GOCE, the quality of the GPS and levelling data and the averaging control the accuracy of the vertical datum offset estimates. In case the omission error does not cancel out in the mean value computation, because of a sub-optimal point distribution or a characteristic behaviour of the omitted part of the geoid signal, one needs to estimate a correction for the omission error from other sources. For areas with dense and high quality ground observations the EGM2008 global model is a good choice to estimate the omission error correction in theses cases. Relative intercontinental height datum offsets are estimated by applying this procedure between the United State of America (USA), Australia and Germany. These are compared to historical values provided in the literature and computed with the same procedure. The results obtained in this study agree on a level of 10 cm to the historical results. The changes mainly can be attributed to the new global geoid information from GOCE, rather than to the ellipsoidal heights or the levelled heights. These historical levelling data are still in use in many countries. This conclusion is supported by other results on the validation of the GOCE models.

Seasonal Dependence of Geomagnetic Active-Time Northern High-Latitude Upper Thermospheric Winds

NASA Astrophysics Data System (ADS)

Dhadly, Manbharat S.; Emmert, John T.; Drob, Douglas P.; Conde, Mark G.; Doornbos, Eelco; Shepherd, Gordon G.; Makela, Jonathan J.; Wu, Qian; Nieciejewski, Richard J.; Ridley, Aaron J.

2018-01-01

This study is focused on improving the poorly understood seasonal dependence of northern high-latitude F region thermospheric winds under active geomagnetic conditions. The gaps in our understanding of the dynamic high-latitude thermosphere are largely due to the sparseness of thermospheric wind measurements. With current observational facilities, it is infeasible to construct a synoptic picture of thermospheric winds, but enough data with wide spatial and temporal coverage have accumulated to construct a meaningful statistical analysis. We use long-term data from eight ground-based and two space-based instruments to derive climatological wind patterns as a function of magnetic local time, magnetic latitude, and season. These diverse data sets possess different geometries and different spatial and solar activity coverage. The major challenge is to combine these disparate data sets into a coherent picture while overcoming the sampling limitations and biases among them. In our previous study (focused on quiet time winds), we found bias in the Gravity Field and Steady State Ocean Circulation Explorer (GOCE) cross-track winds. Here we empirically quantify the GOCE bias and use it as a correction profile for removing apparent bias before empirical wind formulation. The assimilated wind patterns exhibit all major characteristics of high-latitude neutral circulation. The latitudinal extent of duskside circulation expands almost 10∘ from winter to summer. The dawnside circulation subsides from winter to summer. Disturbance winds derived from geomagnetic active and quiet winds show strong seasonal and latitudinal variability. Comparisons between wind patterns derived here and Disturbance Wind Model (DWM07) (which have no seasonal dependence) suggest that DWM07 is skewed toward summertime conditions.

Tidal Signals In GOCE Measurements And Time-GCM

NASA Astrophysics Data System (ADS)

Hausler, K.; Hagan, M. E.; Lu, G.; Doornbos, E.; Bruinsma, S.; Forbes, J. M.

2013-12-01

In this paper we investigate tidal signatures in GOCE measurements during 15-24 November 2009 and complementary simulations with the Thermosphere-Ionosphere- Mesosphere-Electrodynamics General Circulation Model (TIME-GCM). The TIME-GCM simulations are driven by inputs that represent the prevailing solar and geomagnetic conditions along with tidal and planetary waves applied at the lower boundary (ca. 30km). For this pilot study, the resultant TIME-GCM densities are analyzed in two ways: 1) we use results along the GOCE orbital track, to calculate ascending/descending orbit longitude- latitude density difference and sum maps for direct comparison with the GOCE diagnostics, and 2) we conduct a complete analysis of TIME-GCM results to unambiguously characterize the simulated atmospheric tides and to attribute the observed longitude variations to specific tidal components. TIME-GCM captures some but not all of the observed longitudinal variability. The good data- model agreement for wave-2, wave-3, and wave-4 suggests that thermospheric impacts can be attributed to the DE1, DE2, DE3, S0, SE1, and SE2 tides. Discrepancies between TIME-GCM and GOCE results are most prominent in the wave-1 variations, and suggest that further refinement of the lower boundary forcing is necessary before we extend our analysis and interpretation to densities associated with the remainder of the GOCE mission.

The gravity field model IGGT_R1 based on the second invariant of the GOCE gravitational gradient tensor

NASA Astrophysics Data System (ADS)

Lu, Biao; Luo, Zhicai; Zhong, Bo; Zhou, Hao; Flechtner, Frank; Förste, Christoph; Barthelmes, Franz; Zhou, Rui

2017-11-01

Based on tensor theory, three invariants of the gravitational gradient tensor (IGGT) are independent of the gradiometer reference frame (GRF). Compared to traditional methods for calculation of gravity field models based on the gravity field and steady-state ocean circulation explorer (GOCE) data, which are affected by errors in the attitude indicator, using IGGT and least squares method avoids the problem of inaccurate rotation matrices. The IGGT approach as studied in this paper is a quadratic function of the gravity field model's spherical harmonic coefficients. The linearized observation equations for the least squares method are obtained using a Taylor expansion, and the weighting equation is derived using the law of error propagation. We also investigate the linearization errors using existing gravity field models and find that this error can be ignored since the used a-priori model EIGEN-5C is sufficiently accurate. One problem when using this approach is that it needs all six independent gravitational gradients (GGs), but the components V_{xy} and V_{yz} of GOCE are worse due to the non-sensitive axes of the GOCE gradiometer. Therefore, we use synthetic GGs for both inaccurate gravitational gradient components derived from the a-priori gravity field model EIGEN-5C. Another problem is that the GOCE GGs are measured in a band-limited manner. Therefore, a forward and backward finite impulse response band-pass filter is applied to the data, which can also eliminate filter caused phase change. The spherical cap regularization approach (SCRA) and the Kaula rule are then applied to solve the polar gap problem caused by GOCE's inclination of 96.7° . With the techniques described above, a degree/order 240 gravity field model called IGGT_R1 is computed. Since the synthetic components of V_{xy} and V_{yz} are not band-pass filtered, the signals outside the measurement bandwidth are replaced by the a-priori model EIGEN-5C. Therefore, this model is practically a combined gravity field model which contains GOCE GGs signals and long wavelength signals from the a-priori model EIGEN-5C. Finally, IGGT_R1's accuracy is evaluated by comparison with other gravity field models in terms of difference degree amplitudes, the geostrophic velocity in the Agulhas current area, gravity anomaly differences as well as by comparison to GNSS/leveling data.

Adaptive filtering of GOCE-derived gravity gradients of the disturbing potential in the context of the space-wise approach

NASA Astrophysics Data System (ADS)

Piretzidis, Dimitrios; Sideris, Michael G.

2017-09-01

Filtering and signal processing techniques have been widely used in the processing of satellite gravity observations to reduce measurement noise and correlation errors. The parameters and types of filters used depend on the statistical and spectral properties of the signal under investigation. Filtering is usually applied in a non-real-time environment. The present work focuses on the implementation of an adaptive filtering technique to process satellite gravity gradiometry data for gravity field modeling. Adaptive filtering algorithms are commonly used in communication systems, noise and echo cancellation, and biomedical applications. Two independent studies have been performed to introduce adaptive signal processing techniques and test the performance of the least mean-squared (LMS) adaptive algorithm for filtering satellite measurements obtained by the gravity field and steady-state ocean circulation explorer (GOCE) mission. In the first study, a Monte Carlo simulation is performed in order to gain insights about the implementation of the LMS algorithm on data with spectral behavior close to that of real GOCE data. In the second study, the LMS algorithm is implemented on real GOCE data. Experiments are also performed to determine suitable filtering parameters. Only the four accurate components of the full GOCE gravity gradient tensor of the disturbing potential are used. The characteristics of the filtered gravity gradients are examined in the time and spectral domain. The obtained filtered GOCE gravity gradients show an agreement of 63-84 mEötvös (depending on the gravity gradient component), in terms of RMS error, when compared to the gravity gradients derived from the EGM2008 geopotential model. Spectral-domain analysis of the filtered gradients shows that the adaptive filters slightly suppress frequencies in the bandwidth of approximately 10-30 mHz. The limitations of the adaptive LMS algorithm are also discussed. The tested filtering algorithm can be connected to and employed in the first computational steps of the space-wise approach, where a time-wise Wiener filter is applied at the first stage of GOCE gravity gradient filtering. The results of this work can be extended to using other adaptive filtering algorithms, such as the recursive least-squares and recursive least-squares lattice filters.

Europe's Preparation For GOCE Gravity Field Recovery

NASA Astrophysics Data System (ADS)

Suenkel, H.; Suenkel, H.

2001-12-01

The European Space Agency ESA is preparing for its first dedicated gravity field mission GOCE (Gravity Field and Steady-state Ocean Circulation Explorer) with a proposed launch in fall 2005. The mission's goal is the mapping of the Earth's static gravity field with very high resolution and utmost accuracy on a global scale. GOCE is a drag-free mission, flown in a circular and sun-synchronous orbit at an altitude between 240 and 250 km. Each of the two operational phases will last for 6 months. GOCE is based on a sensor fusion concept combining high-low satellite-to-satellite tracking (SST) and satellite gravity gradiometry (SGG). The transformation of the GOCE sensor data into a scientific product of utmost quality and reliability requires a well-coordinated effort of experts in satellite geodesy, applied mathematics and computer science. Several research groups in Europe do have this expertise and decided to form the "European GOCE Gravity Consortium (EGG-C)". The EGG-C activities are subdivided into tasks such as standard and product definition, data base and data dissemination, precise orbit determination, global gravity field model solutions and regional solutions, solution validation, communication and documentation, and the interfacing to level 3 product scientific users. The central issue of GOCE data processing is, of course, the determination of the global gravity field model using three independent mathematical-numerical techniques which had been designed and pre-developed in the course of several scientific preparatory studies of ESA: 1. The direct solution which is a least squares adjustment technique based on a pre-conditioned conjugated gradient method (PCGM). The method is capable of efficiently transforming the calibrated and validated SST and SGG observations directly or via lumped coefficients into harmonic coefficients of the gravitational potential. 2. The time-wise approach considers both SST and SGG data as a time series. For an idealized repeat mission such a time series can be very efficiently transformed into lumped coefficients using fast Fourier techniques. For a realistic mission scenario this transformation has to be extended by an iteration process. 3. The space-wise approach which, after having transformed the original observations onto a spatial geographical grid, transforms the pseudo-observations into harmonic coefficients using a fast collocation technique. A successful mission presupposed, GOCE will finally deliver the Earth's gravity field with a resolution of about 70 km half wavelength and a global geoid with an accuracy of about 1 cm.

Software Analysis of New Space Gravity Data for Geophysics and Climate Research

NASA Technical Reports Server (NTRS)

Deese, Rupert; Ivins, Erik R.; Fielding, Eric J.

2012-01-01

Both the Gravity Recovery and Climate Experiment (GRACE) and Gravity field and steady-state Ocean Circulation Explorer (GOCE) satellites are returning rich data for the study of the solid earth, the oceans, and the climate. Current software analysis tools do not provide researchers with the ease and flexibility required to make full use of this data. We evaluate the capabilities and shortcomings of existing software tools including Mathematica, the GOCE User Toolbox, the ICGEM's (International Center for Global Earth Models) web server, and Tesseroids. Using existing tools as necessary, we design and implement software with the capability to produce gridded data and publication quality renderings from raw gravity data. The straight forward software interface marks an improvement over previously existing tools and makes new space gravity data more useful to researchers. Using the software we calculate Bouguer anomalies of the gravity tensor's vertical component in the Gulf of Mexico, Antarctica, and the 2010 Maule earthquake region. These maps identify promising areas of future research.

Global ionospheric and thermospheric response to the 5 April 2010 geomagnetic storm: An integrated data-model investigation

NASA Astrophysics Data System (ADS)

Lu, G.; Hagan, M. E.; Häusler, K.; Doornbos, E.; Bruinsma, S.; Anderson, B. J.; Korth, H.

2014-12-01

We present a case study of the 5 April 2010 geomagnetic storm using observations and numerical simulations. The event was driven by a fast-moving coronal mass ejection and despite being a moderate storm with a minimum Dst near -50 nT, the event exhibited elevated thermospheric density and surges of traveling atmospheric disturbances (TADs) more typically seen during major storms. The Thermosphere-Ionosphere-Mesosphere-Electrodynamics General Circulation Model (TIMEGCM) was used to assess how these features were generated and developed during the storm. The model simulations gave rise to TADs that were highly nonuniform with strong latitude and longitude/local time dependence. The TAD phase speeds ranged from 640 m/s to 780 m/s at 400 km and were ~5% lower at 300 km and approximately 10-15% lower at 200 km. In the lower thermosphere around 100 km, the TAD signatures were nearly unrecognizable due to much stronger influence of upward propagating atmospheric tides. The thermosphere simulation results were compared to observations available from the Gravity Field and Steady-State Ocean Circulation Explorer (GOCE), CHAllenging Minisatellite Payload (CHAMP) and Gravity Recovery and Climate Experiment (GRACE) satellites. Comparison with GOCE data shows that the TIMEGCM reproduced the cross-track winds over the polar region very well. The model-data comparison also revealed some differences, specifically, the simulations underestimated neutral mass density in the upper thermosphere above ~300 km and overestimated the storm recovery tome by 6 h. These discrepancies indicate that some heating or circulation dynamics and potentially cooling processes are not fully represented in the simulations, and also that updates to some parameterization schemes in the TIMEGCM are warranted.

A contrastive study on the influences of radial and three-dimensional satellite gravity gradiometry on the accuracy of the Earth's gravitational field recovery

NASA Astrophysics Data System (ADS)

Zheng, Wei; Hsu, Hou-Tse; Zhong, Min; Yun, Mei-Juan

2012-10-01

The accuracy of the Earth's gravitational field measured from the gravity field and steady-state ocean circulation explorer (GOCE), up to 250 degrees, influenced by the radial gravity gradient Vzz and three-dimensional gravity gradient Vij from the satellite gravity gradiometry (SGG) are contrastively demonstrated based on the analytical error model and numerical simulation, respectively. Firstly, the new analytical error model of the cumulative geoid height, influenced by the radial gravity gradient Vzz and three-dimensional gravity gradient Vij are established, respectively. In 250 degrees, the GOCE cumulative geoid height error measured by the radial gravity gradient Vzz is about 2½ times higher than that measured by the three-dimensional gravity gradient Vij. Secondly, the Earth's gravitational field from GOCE completely up to 250 degrees is recovered using the radial gravity gradient Vzz and three-dimensional gravity gradient Vij by numerical simulation, respectively. The study results show that when the measurement error of the gravity gradient is 3 × 10-12/s2, the cumulative geoid height errors using the radial gravity gradient Vzz and three-dimensional gravity gradient Vij are 12.319 cm and 9.295 cm at 250 degrees, respectively. The accuracy of the cumulative geoid height using the three-dimensional gravity gradient Vij is improved by 30%-40% on average compared with that using the radial gravity gradient Vzz in 250 degrees. Finally, by mutual verification of the analytical error model and numerical simulation, the orders of magnitude from the accuracies of the Earth's gravitational field recovery make no substantial differences based on the radial and three-dimensional gravity gradients, respectively. Therefore, it is feasible to develop in advance a radial cold-atom interferometric gradiometer with a measurement accuracy of 10-13/s2-10-15/s2 for precisely producing the next-generation GOCE Follow-On Earth gravity field model with a high spatial resolution.

That gravity thing

NASA Astrophysics Data System (ADS)

Jewess, Mike

2009-05-01

Your news article "New probe plots Earth's gravity field" (March p11) reports on the European Space Agency's Gravity Field and Steady-State Ocean Circulation Explorer (GOCE) - a satellite that will measure the Earth's gravitational field. It describes the way that g, the acceleration of free fall at the Earth's surface, varies with latitude; this variation is great enough to require adjustment of pendulum clocks between latitudes and also the recalibration of all balances that do not directly compare one mass with a reference mass. The article also notes that the spin of the (effectively fluid) Earth causes it to bulge at the equator, a realization that goes back to Newton's Principia.

Global mean dynamic topography based on GOCE data and Wiener filters

NASA Astrophysics Data System (ADS)

Gilardoni, Maddalena; Reguzzoni, Mirko; Albertella, Alberta

2015-04-01

A mean dynamic ocean topography (MDT) has been computed by using a GOCE-only gravity model and a given mean sea surface (MSS) obtained from satellite altimetry. Since the used gravity model, i.e. the fifth release of the time-wise solution covering the full mission lifetime, is truncated at a maximum harmonic degree of 280, the obtained MDT has to be consistently filtered. This has been done globally by using the spherical harmonic representation and following a Wiener minimization principle. This global filtering approach is convenient from the computational point of view but requires to have MDT values all over the Earth surface and therefore to fill the continents with fictitious data. The main improvements with respect to the already presented results are in the MDT filling procedure (to guarantee that the global signal has the same covariance of the one over the oceans), in the error modelling of the input MSS and in the error estimation of the filtered MDT and of the corresponding geostrophic velocities. The impact of GOCE data in the ocean circulation global modelling has been assessed by comparing the pattern of the obtained geostrophic currents with those computed by using EGM2008. Comparisons with independent circulation data based on drifters and other MDT models have been also performed with the aim of evaluating the accuracy of the obtained results.

GOCE and Future Gravity Missions for Geothermal Energy Exploitation

NASA Astrophysics Data System (ADS)

Pastorutti, Alberto; Braitenberg, Carla; Pivetta, Tommaso; Mariani, Patrizia

2016-08-01

Geothermal energy is a valuable renewable energy source the exploitation of which contributes to the worldwide reduction of consumption of fossil fuels oil and gas. The exploitation of geothermal energy is facilitated where the thermal gradient is higher than average leading to increased surface heat flow. Apart from the hydrologic circulation properties which depend on rock fractures and are important due to the heat transportation from the hotter layers to the surface, essential properties that increase the thermal gradient are crustal thinning and radiogenic heat producing rocks. Crustal thickness and rock composition form the link to the exploration with the satellite derived gravity field, because both induce subsurface mass changes that generate observable gravity anomalies. The recognition of gravity as a useful investigation tool for geothermal energy lead to a cooperation with ESA and the International Renewable Energy Agency (IRENA) that included the GOCE derived gravity field in the online geothermal energy investigation tool of the IRENA database. The relation between the gravity field products as the free air gravity anomaly, the Bouguer and isostatic anomalies and the heat flow values is though not straightforward and has not a unique relationship. It is complicated by the fact that it depends on the geodynamical context, on the geologic context and the age of the crustal rocks. Globally the geological context and geodynamical history of an area is known close to everywhere, so that a specific known relationship between gravity and geothermal potential can be applied. In this study we show the results of a systematic analysis of the problem, including some simulations of the key factors. The study relies on the data of GOCE and the resolution and accuracy of this satellite. We also give conclusions on the improved exploration power of a gravity mission with higher spatial resolution and reduced data error, as could be achieved in principle by flying an atom interferometer sensor on board a satellite.

On High-Frequency Topography-Implied Gravity Signals for a Height System Unification Using GOCE-Based Global Geopotential Models

NASA Astrophysics Data System (ADS)

Grombein, Thomas; Seitz, Kurt; Heck, Bernhard

2017-03-01

National height reference systems have conventionally been linked to the local mean sea level, observed at individual tide gauges. Due to variations in the sea surface topography, the reference levels of these systems are inconsistent, causing height datum offsets of up to ±1-2 m. For the unification of height systems, a satellite-based method is presented that utilizes global geopotential models (GGMs) derived from ESA's satellite mission Gravity field and steady-state Ocean Circulation Explorer (GOCE). In this context, height datum offsets are estimated within a least squares adjustment by comparing the GGM information with measured GNSS/leveling data. While the GNSS/leveling data comprises the full spectral information, GOCE GGMs are restricted to long wavelengths according to the maximum degree of their spherical harmonic representation. To provide accurate height datum offsets, it is indispensable to account for the remaining signal above this maximum degree, known as the omission error of the GGM. Therefore, a combination of the GOCE information with the high-resolution Earth Gravitational Model 2008 (EGM2008) is performed. The main contribution of this paper is to analyze the benefit, when high-frequency topography-implied gravity signals are additionally used to reduce the remaining omission error of EGM2008. In terms of a spectral extension, a new method is proposed that does not rely on an assumed spectral consistency of topographic heights and implied gravity as is the case for the residual terrain modeling (RTM) technique. In the first step of this new approach, gravity forward modeling based on tesseroid mass bodies is performed according to the Rock-Water-Ice (RWI) approach. In a second step, the resulting full spectral RWI-based topographic potential values are reduced by the effect of the topographic gravity field model RWI_TOPO_2015, thus, removing the long to medium wavelengths. By using the latest GOCE GGMs, the impact of topography-implied gravity signals on the estimation of height datum offsets is analyzed in detail for representative GNSS/leveling data sets in Germany, Austria, and Brazil. Besides considerable changes in the estimated offset of up to 3 cm, the conducted analyses show that significant improvements of 30-40% can be achieved in terms of a reduced standard deviation and range of the least squares adjusted residuals.

GOCE gravity gradient data for lithospheric modeling and geophysical exploration research

NASA Astrophysics Data System (ADS)

Bouman, Johannes; Ebbing, Jörg; Meekes, Sjef; Lieb, Verena; Fuchs, Martin; Schmidt, Michael; Fattah, Rader Abdul; Gradmann, Sofie; Haagmans, Roger

2013-04-01

GOCE gravity gradient data can improve modeling of the Earth's lithosphere and upper mantle, contributing to a better understanding of the Earth's dynamic processes. We present a method to compute user-friendly GOCE gravity gradient grids at mean satellite altitude, which are easier to use than the original GOCE gradients that are given in a rotating instrument frame. In addition, the GOCE gradients are combined with terrestrial gravity data to obtain high resolution grids of gravity field information close to the Earth's surface. We also present a case study for the North-East Atlantic margin, where we analyze the use of satellite gravity gradients by comparison with a well-constrained 3D density model that provides a detailed picture from the upper mantle to the top basement (base of sediments). We demonstrate how gravity gradients can increase confidence in the modeled structures by calculating the sensitvity of model geometry and applied densities at different observation heights; e.g. satellite height and near surface. Finally, this sensitivity analysis is used as input to study the Rub' al Khali desert in Saudi Arabia. In terms of modeling and data availability this is a frontier area. Here gravity gradient data help especially to set up the regional crustal structure, which in turn allows to refine sedimentary thickness estimates and the regional heat-flow pattern. This can have implications for hydrocarbon exploration in the region.

Kelvin wave coupling from TIMED and GOCE: Inter/intra-annual variability and solar activity effects

NASA Astrophysics Data System (ADS)

Gasperini, Federico; Forbes, Jeffrey M.; Doornbos, Eelco N.; Bruinsma, Sean L.

2018-06-01

The primary mechanism through which energy and momentum are transferred from the lower atmosphere to the thermosphere is through the generation and propagation of atmospheric waves. It is becoming increasingly evident that a few waves from the tropical wave spectrum preferentially propagate into the thermosphere and contribute to modify satellite drag. Two of the more prominent and well-established tropical waves are Kelvin waves: the eastward-propagating 3-day ultra-fast Kelvin wave (UFKW) and the eastward-propagating diurnal tide with zonal wave number 3 (DE3). In this work, Sounding of the Atmosphere using Broadband Emission Radiometry (SABER) temperatures at 110 km and Gravity field and steady-state Ocean Circulation Explorer (GOCE) neutral densities and cross-track winds near 260 km are used to demonstrate vertical coupling in this height regime due to the UFKW and DE3. Significant inter- and intra-annual variability is found in DE3 and the UFKW, with evidence of latitudinal broadening and filtering of the latitude structures with height due to the effect of dissipation and mean winds. Additionally, anti-correlation between the vertical penetration of these waves to the middle thermosphere and solar activity level is established and explained through the effect of molecular dissipation.

Local recovery of lithospheric stress tensor from GOCE gravitational tensor

NASA Astrophysics Data System (ADS)

Eshagh, Mehdi

2017-04-01

The sublithospheric stress due to mantle convection can be computed from gravity data and propagated through the lithosphere by solving the boundary-value problem of elasticity for the Earth's lithosphere. In this case, a full tensor of stress can be computed at any point inside this elastic layer. Here, we present mathematical foundations for recovering such a tensor from gravitational tensor measured at satellite altitudes. The mathematical relations will be much simpler in this way than the case of using gravity data as no derivative of spherical harmonics (SHs) or Legendre polynomials is involved in the expressions. Here, new relations between the SH coefficients of the stress and gravitational tensor elements are presented. Thereafter, integral equations are established from them to recover the elements of stress tensor from those of the gravitational tensor. The integrals have no closed-form kernels, but they are easy to invert and their spatial truncation errors are reducible. The integral equations are used to invert the real data of the gravity field and steady-state ocean circulation explorer mission (GOCE), in 2009 November, over the South American plate and its surroundings to recover the stress tensor at a depth of 35 km. The recovered stress fields are in good agreement with the tectonic and geological features of the area.

Comparisons Between TIME-GCM/MERRA Simulations and LEO Satellite Observations

NASA Astrophysics Data System (ADS)

Hagan, M. E.; Haeusler, K.; Forbes, J. M.; Zhang, X.; Doornbos, E.; Bruinsma, S.; Lu, G.

2014-12-01

We report on yearlong National Center for Atmospheric Research (NCAR) thermosphere-ionosphere-mesosphere-electrodynamics general circulation model (TIME-GCM) simulations where we utilize the recently developed lower boundary condition based on 3-hourly MERRA (Modern-Era Retrospective Analysis for Research and Application) reanalysis data to account for tropospheric waves and tides propagating upward into the model domain. The solar and geomagnetic forcing is based on prevailing geophysical conditions. The simulations show a strong day-to-day variability in the upper thermospheric neutral temperature tidal fields, which is smoothed out quickly when averaging is applied over several days, e.g. up to 50% DE3 amplitude reduction for a 10-day average. This is an important result with respect to tidal diagnostics from satellite observations where averaging over multiple days is inevitable. In order to assess TIME-GCM performance we compare the simulations with measurements from the Gravity field and steady-state Ocean Circulation Explorer (GOCE), Challenging Minisatellite Payload (CHAMP) and Gravity Recovery and Climate Experiment (GRACE) satellites.

Orbital Gravity Gradiometry Beyond GOCE: Mission Concepts

NASA Technical Reports Server (NTRS)

Shirron, Peter J.; DiPirro, Michael J.; Canavan, Edgar R.; Paik, Ho Jung; Moody, M. Vol; Venkateswara, Krishna Y.; Han, Shin-Chan; Ditmar, Pavel; Klees, Roland; Jekeli, Christopher;

Thermosphere Response to Geomagnetic Variability during Solar Minimum Conditions

NASA Astrophysics Data System (ADS)

Forbes, Jeffrey; Gasperini, Federico; Zhang, Xiaoli; Doornbos, Eelco; Bruinsma, Sean; Haeusler, Kathrin; Hagan, Maura

2015-04-01

The response of thermosphere mass density to variable geomagnetic activity at solar minimum is revealed as a function of height utilizing accelerometer data from GRACE near 480 km, CHAMP near 320 km, and GOCE near 260 km during the period October-December, 2009. The GOCE data at 260 km, and to some degree the CHAMP measurements at 320 km, reveal the interesting feature that the response maximum occurs at low latitudes, rather than at high latitudes where the geomagnetic energy input is presumed to be deposited. The latitude distribution of the response is opposite to what one might expect based on thermal expansion and/or increase in mean molecular weight due to vertical transport of N2 at high latitudes. We speculate that what is observed reflects the consequences of an equatorward meridional circulation with downward motion and compressional heating at low latitudes. A numerical simulation using the National Center for Atmospheric Research (NCAR) Thermosphere-Ionosphere-Mesosphere Electrodynamics General Circulation Model (TIME-GCM) is used to assist with this diagnosis. At 480 km GRACE reveals maximum density responses at high southern (winter) latitudes, consistent with recent interpretations in terms of compositional versus temperature effects near the oxygen-helium transition altitude during low solar activity.

Preprocessing of gravity gradients at the GOCE high-level processing facility

NASA Astrophysics Data System (ADS)

Bouman, Johannes; Rispens, Sietse; Gruber, Thomas; Koop, Radboud; Schrama, Ernst; Visser, Pieter; Tscherning, Carl Christian; Veicherts, Martin

2009-07-01

One of the products derived from the gravity field and steady-state ocean circulation explorer (GOCE) observations are the gravity gradients. These gravity gradients are provided in the gradiometer reference frame (GRF) and are calibrated in-flight using satellite shaking and star sensor data. To use these gravity gradients for application in Earth scienes and gravity field analysis, additional preprocessing needs to be done, including corrections for temporal gravity field signals to isolate the static gravity field part, screening for outliers, calibration by comparison with existing external gravity field information and error assessment. The temporal gravity gradient corrections consist of tidal and nontidal corrections. These are all generally below the gravity gradient error level, which is predicted to show a 1/ f behaviour for low frequencies. In the outlier detection, the 1/ f error is compensated for by subtracting a local median from the data, while the data error is assessed using the median absolute deviation. The local median acts as a high-pass filter and it is robust as is the median absolute deviation. Three different methods have been implemented for the calibration of the gravity gradients. All three methods use a high-pass filter to compensate for the 1/ f gravity gradient error. The baseline method uses state-of-the-art global gravity field models and the most accurate results are obtained if star sensor misalignments are estimated along with the calibration parameters. A second calibration method uses GOCE GPS data to estimate a low-degree gravity field model as well as gravity gradient scale factors. Both methods allow to estimate gravity gradient scale factors down to the 10-3 level. The third calibration method uses high accurate terrestrial gravity data in selected regions to validate the gravity gradient scale factors, focussing on the measurement band. Gravity gradient scale factors may be estimated down to the 10-2 level with this method.

Combining GOCE and in-situ gravity data for precise gravity field determination and geophysical applications around the Japanese Antarctic station, Syowa, in Antarctica

NASA Astrophysics Data System (ADS)

Fukuda, Y.; Nogi, Y.; Matsuzaki, K.

2012-12-01

Syowa is the Japanese Antarctic wintering station in Lützow-Holm Bay, East Antarctica. The area around the station is considered to be a key for investigating the formation of Gondwana, because reconstruction models suggest a junction of the continents locates in the area. It is also important from a glaciological point of view, because there locates the Shirase Glacier, one of the major glaciers in Antarctica, near the station. Therefore the Japanese Antarctic Research Expedition (JARE) has been conducting in-situ gravity measurements in the area for a long period. The data sets accumulated are land gravity data since 1967, surface ship data since 1985, and airborne gravity data in 2006. However these in-situ gravity data usually suffered from the effects of instrumental drifts and lack of reference points, their accuracies are decreasing toward the longer wavelength more than several tens km. In particular in Antarctica where very few gravity reference points are available, the long wavelength accuracy and/or consistency among the data sets are quite limited. GOCE (Gravity field and steady-state Ocean Circulation Explorer) satellite launched in March 2009 by ESA (European Space Agency) aims at improving static gravity fields, in particular at short wavelengths. In addition to its low-altitude orbit (250km), the sensitive gravity gradiometer installed is expected to reveal 1 mgal gravity anomalies at the spatial resolution of 100km (half wavelength). Actually recently released GOCE EGMs (Earth Gravity Models) have improved the accuracy of the static gravity filed tremendously. These EGMs are expected to serve as the long wavelength references for the in-situ gravity data. Thus, firstly, we aims at determining an improved gravity fields around Syowa by combining the JARE gravity data and the recent EGMs. And then, using the gravity anomalies, we determine the subsurface density structures. We also evaluated the impacts of the EGMs for estimating the density structures.

Matching Lithosphere velocity changes to the GOCE gravity signal

NASA Astrophysics Data System (ADS)

Braitenberg, Carla

2016-07-01

Authors: Carla Braitenberg, Patrizia Mariani, Alberto Pastorutti Department of Mathematics and Geosciences, University of Trieste Via Weiss 1, 34100 Trieste Seismic tomography models result in 3D velocity models of lithosphere and sublithospheric mantle, which are due to mineralogic compositional changes and variations in the thermal gradient. The assignment of density is non-univocal and can lead to inverted density changes with respect to velocity changes, depending on composition and temperature. Velocity changes due to temperature result in a proportional density change, whereas changes due to compositional changes and age of the lithosphere can lead to density changes of inverted sign. The relation between velocity and density implies changes in the lithosphere rigidity. We analyze the GOCE gradient fields and the velocity models jointly, making simulations on thermal and compositional density changes, using the velocity models as constraint on lithosphere geometry. The correlations are enhanced by applying geodynamic plate reconstructions to the GOCE gravity field and the tomography models which places today's observed fields at the Gondwana pre-breakup position. We find that the lithosphere geometry is a controlling factor on the overlying geologic elements, defining the regions where rifting and collision alternate and repeat through time. The study is carried out globally, with focus on the conjugate margins of the African and South American continents. The background for the study can be found in the following publications where the techniques which have been used are described: Braitenberg, C., Mariani, P. and De Min, A. (2013). The European Alps and nearby orogenic belts sensed by GOCE, Boll. Bollettino di Geofisica Teorica ed Applicata, 54(4), 321-334. doi:10.4430/bgta0105---- Braitenberg, C. and Mariani, P. (2015). Geological implications from complete Gondwana GOCE-products reconstructions and link to lithospheric roots. Proceedings of 5th International GOCE User Workshop, 25 - 28 November 2014.---- Braitenberg, C. (2015). Exploration of tectonic structures with GOCE in Africa and across-continents. Int. J.Appl. Earth Observ. Geoinf. 35, 88-95. http://dx.doi.org/10.1016/j.jag.2014.01.013------ Braitenberg, C. (2015). A grip on geological units with GOCE, IAG Symp. 141

Use of surface drifters to increase resolution and accuracy of oceanic geostrophic circulation mapped from satellite only (altimetry and gravimetry)

NASA Astrophysics Data System (ADS)

Mulet, Sandrine; Rio, Marie-Hélène; Etienne, Hélène

2017-04-01

Strong improvements have been made in our knowledge of the surface ocean geostrophic circulation thanks to satellite observations. For instance, the use of the latest GOCE (Gravity field and steady-state Ocean Circulation Explorer) geoid model with altimetry data gives good estimate of the mean oceanic circulation at spatial scales down to 125 km. However, surface drifters are essential to resolve smaller scales, it is thus mandatory to carefully process drifter data and then to combine these different data sources. In this framework, the global 1/4° CNES-CLS13 Mean Dynamic Topography (MDT) and associated mean geostrophic currents have been computed (Rio et al, 2014). First a satellite only MDT was computed from altimetric and gravimetric data. Then, an important work was to pre-process drifter data to extract only the geostrophic component in order to be consistent with physical content of satellite only MDT. This step include estimate and remove of Ekman current and wind slippage. Finally drifters and satellite only MDT were combined. Similar approaches are used regionally to go further toward higher resolution, for instance in the Agulhas current or along the Brazilian coast. Also, a case study in the Gulf of Mexico intends to use drifters in the same way to improve weekly geostrophic current estimate.

GOCE observations for Mineral exploration in Africa and across continents

NASA Astrophysics Data System (ADS)

Braitenberg, Carla

2014-05-01

The gravity anomaly field over the whole Earth obtained by the GOCE satellite is a revolutionary tool to reveal geologic information on a continental scale for the large areas where conventional gravity measurements have yet to be made (e.g. Alvarez et al., 2012). It is, however, necessary to isolate the near-surface geologic signal from the contributions of thickness variations in the crust and lithosphere and the isostatic compensation of surface relief (e.g. Mariani et al., 2013) . Here Africa is studied with particular emphasis on selected geological features which are expected to appear as density inhomogeneities. These include cratons and fold belts in the Precambrian basement, the overlying sedimentary basins and magmatism, as well as the continental margins. Regression analysis between gravity and topography shows coefficients that are consistently positive for the free air gravity anomaly and negative for the Bouguer gravity anomaly (Braitenberg et al., 2013; 2014). The error and scatter on the regression is smallest in oceanic areas, where it is a possible tool for identifying changes in crustal type. The regression analysis allows the large gradient in the Bouguer anomaly signal across continental margins to be removed. After subtracting the predicted effect of known topography from the original Bouguer anomaly field, the residual field shows a continent-wide pattern of anomalies that can be attributed to regional geological structures. A few of these are highlighted, such as those representing Karoo magmatism, the Kibalian foldbelt, the Zimbabwe Craton, the Cameroon and Tibesti volcanic deposits, the Benue Trough and the Luangwa Rift. A reconstruction of the pre-break up position of Africa, South and North America is made for the residual GOCE gravity field obtaining today's gravity field of the plates forming West Gondwana. The reconstruction allows the positive and negative anomalies to be compared across the continental fragments, and so helps identify common geologic units that extend across both the now-separate continents. Tracing the geologic units is important for mineral exploration, which is demonstrated with the analysis of correlations of the gravity signal with selected classes of mineral occurrences, for instance those associated to Greenstone belts. Alvarez, O., Gimenez M., Braitenberg C., Folguera, A. (2012) GOCE Satellite derived Gravity and Gravity gradient corrected for topographic effect in the South Central Andes Region. Geophysical Journal International, 190, 941-959, doi: 10.1111/j.1365-246X.2012.05556.x Braitenberg C., Mariani P., De Min A. (2013) The European Alps and nearby orogenic belts sensed by GOCE, Boll. Bollettino di Geofisica Teorica ed Applicata, doi:10.4430/bgta0105 Braitenberg C. (2014) Exploration of tectonic structures with GOCE in Africa and across-continents, J.of Applied Earth Observation and Geoinformation (in Review). Mariani P., Braitenberg C., Ussami N. (2013). Explaining the thick crust in Parana' basin, Brazil, with satellite GOCE-gravity observations. Journal of South American Earth Sciences, 45, 209-223, doi:10.1016/j.jsames.2013.03.008.

Moho depth model for the Central Asian Orogenic Belt from satellite gravity gradients

NASA Astrophysics Data System (ADS)

Guy, Alexandra; Holzrichter, Nils; Ebbing, Jörg

2017-09-01

The main purpose of this study is to construct a new 3-D model of the Central Asian Orogenic Belt (CAOB) crust, which can be used as a starting point for future lithospheric studies. The CAOB is a Paleozoic accretionary orogen surrounded by the Siberian Craton to the north and the North China and Tarim Cratons to the south. This area is of great interest due to its enigmatic and still not completely understood geodynamic evolution. First, we estimate an initial crustal thickness by inversion of the vertical gravity component of the Gravity Field and Steady-State Ocean Circulation Explorer (GOCE) and DTU10 models. Second, 3-D forward modeling of the GOCE gravity gradients is performed, which determines the topography of the Moho, the geometry, and the density distribution of the deeper parts of the CAOB and its surroundings, taking into account the lateral and vertical density variations of the crust. The model is constrained by seismic refraction, reflection, and receiver function studies and geological studies. In addition, we discuss the isostatic implications of the differences between the seismic Moho and the resulting 3-D gravity Moho, complemented by the analysis of the lithostatic load distribution at the upper mantle level. Finally, the correlation between the contrasting tectonic domains and the thickness of the crust reveals the inheritance of Paleozoic and Mesozoic geodynamics, particularly the magmatic provinces and the orocline which preserve their crustal features.

Control of deep lithospheric roots on crustal scale GOCE gravity and gradient fields evident in Gondwana reconstructions

NASA Astrophysics Data System (ADS)

Braitenberg, Carla; Mariani, Patrizia

2015-04-01

The GOCE gravity field is globally homogeneous at the resolution of about 80km or better allowing for the first time to analyze tectonic structures at continental scale. Geologic correlation studies based on age determination and mineral composition of rock samples propose to continue the tectonic lineaments across continents to the pre-breakup position. Tectonic events which induce density changes, as metamorphic events and magmatic events, should then show up in the gravity field. Therefore gravity can be used as a globally available supportive tool for interpolation of isolated samples. Applying geodynamic plate reconstructions to the GOCE gravity field places today's observed field at the pre-breakup position. In order to test the possible deep control of the crustal features, the same reconstruction is applied to the seismic velocity models, and a joint gravity-velocity analysis is performed. The geophysical fields allow to control the likeliness of the hypothesized continuation of lineations based on sparse surface outcrops. Total absence of a signal, makes the cross-continental continuation of the lineament improbable, as continental-wide lineaments are controlled by rheologic and compositional differences of lithospheric mantle. It is found that the deep lithospheric roots as those found below cratons control the position of the positive gravity values. The explanation is that the deep lithospheric roots focus asthenospheric upwelling outboard of the root protecting the overlying craton from magmatic intrusions. The study is carried out over the African and South American continents. The background for the study can be found in the following publications where the techniques which have been used are described: Braitenberg, C., Mariani, P. and De Min, A. (2013). The European Alps and nearby orogenic belts sensed by GOCE, Boll. Bollettino di Geofisica Teorica ed Applicata, 54(4), 321-334. doi:10.4430/bgta0105 Braitenberg, C. and Mariani, P. (2015). Geological implications from complete Gondwana GOCE-products reconstructions and link to lithospheric roots. Proceedings of 5th International GOCE User Workshop, 25 - 28 November 2014. Braitenberg, C. (2015). Exploration of tectonic structures with GOCE in Africa and across-continents. Int. J.Appl. Earth Observ. Geoinf. 35, 88-95. http://dx.doi.org/10.1016/j.jag.2014.01.013 Braitenberg, C. (2015). A grip on geological units with GOCE, IAG Symp. 141, in press.

Airborne gravimetry for geoid, geopotential models and GOCE - Himalaya and Antarctica cases (Invited)

NASA Astrophysics Data System (ADS)

Forsberg, R.; Olesen, A. V.

2013-12-01

DTU-Space has since many years carried out large area airborne surveys over both polar, tropical and temperate regions, especially for geoid determination and global geopotential models. Recently we have started flying two gravimeters (LCR and Chekan-AM) side by side for increased reliability and redundancy. Typical gravity results are at the 2 mGal rms level, translating into 5-10 cm accuracy in geoid. However, in rough mountainous areas results can be more noisy, mainly due to long-period mountain waves and turbulence. In the paper we outline results of recent challenging campaigns in Nepal (2010) and Antarctica (Antarctic Peninsula and East Antarctica, 2010-13). The latest Antarctic campaign 2012/13, carried out in cooperation with the British Antarctic Survey, Norwegian Polar Institute, and the Argentine Antarctic Institute, involved air drops of fuel to a remote field camp in the Recovery Lakes region, one of the least explored region of deep interior Antarctica. The airborne data collected are validated by cross-over comparisons and comparisons to independent data (IceBridge), and serve at the same time as an independent validation of GOCE satellite gravity data, confirming the satellite data to contain information at half-wavelengths down to 80 km. With no bias between the airborne data and GOCE, airborne gravimetry is perfectly suited to cover the GOCE data gap south of 83 S. We recommend an international, coordinated airborne gravity effort should be carried out over the south polar gap as soon as possible, to ensure a uniform global accuracy of GOCE heritage future geopotential models.

Evaluation of GOCE-based Global Geoid Models in Finnish Territory

NASA Astrophysics Data System (ADS)

Saari, Timo; Bilker-Koivula, Mirjam

2015-04-01

The gravity satellite mission GOCE made its final observations in the fall of 2013. By then it had exceeded its expected lifespan of one year with more than three additional years. Thus, the mission collected more data from the Earth's gravitational field than expected, and more comprehensive global geoid models have been derived ever since. The GOCE High-level Processing Facility (HPF) by ESA has published GOCE global gravity field models annually. We compared all of the 12 HPF-models as well as 3 additional GOCE, 11 GRACE and 6 combined GOCE+GRACE models with GPS-levelling data and gravity observations in Finland. The most accurate models were compared against high resolution global geoid models EGM96 and EGM2008. The models were evaluated up to three different degrees and order: 150 (the common maximum for the GRACE models), 240 (the common maximum for the GOCE models) and maximum. When coefficients up to degree and order 150 are used, the results of the GOCE models are comparable with the results of the latest GRACE models. Generally, all of the latest GOCE and GOCE+GRACE models give standard deviations of the height anomaly differences of around 15 cm and of gravity anomaly differences of around 10 mgal over Finland. The best solutions were not always achieved with the highest maximum degree and order of the satellite gravity field models, since the highest coefficients (above 240) may be less accurately determined. Over Finland, the latest GOCE and GOCE+GRACE models give similar results as the high resolution models EGM96 and EGM2008 when coefficients up to degree and order 240 are used. This is mainly due to the high resolution terrestrial data available in the area of Finland, which was used in the high resolution models.

GOCE gravity field simulation based on actual mission scenario

NASA Astrophysics Data System (ADS)

Pail, R.; Goiginger, H.; Mayrhofer, R.; Höck, E.; Schuh, W.-D.; Brockmann, J. M.; Krasbutter, I.; Fecher, T.; Gruber, T.

2009-04-01

In the framework of the ESA-funded project "GOCE High-level Processing Facility", an operational hardware and software system for the scientific processing (Level 1B to Level 2) of GOCE data has been set up by the European GOCE Gravity Consortium EGG-C. One key component of this software system is the processing of a spherical harmonic Earth's gravity field model and the corresponding full variance-covariance matrix from the precise GOCE orbit and calibrated and corrected satellite gravity gradiometry (SGG) data. In the framework of the time-wise approach a combination of several processing strategies for the optimum exploitation of the information content of the GOCE data has been set up: The Quick-Look Gravity Field Analysis is applied to derive a fast diagnosis of the GOCE system performance and to monitor the quality of the input data. In the Core Solver processing a rigorous high-precision solution of the very large normal equation systems is derived by applying parallel processing techniques on a PC cluster. Before the availability of real GOCE data, by means of a realistic numerical case study, which is based on the actual GOCE orbit and mission scenario and simulation data stemming from the most recent ESA end-to-end simulation, the expected GOCE gravity field performance is evaluated. Results from this simulation as well as recently developed features of the software system are presented. Additionally some aspects on data combination with complementary data sources are addressed.

Using the full tensor of GOCE gravity gradients for regional gravity field modelling

NASA Astrophysics Data System (ADS)

Lieb, Verena; Bouman, Johannes; Dettmering, Denise; Fuchs, Martin; Schmidt, Michael

2013-04-01

With its 3-axis gradiometer GOCE delivers 3-dimensional (3D) information of the Earth's gravity field. This essential advantage - e.g. compared with the 1D gravity field information from GRACE - can be used for research on the Earth's interior and for geophysical exploration. To benefit from this multidimensional measurement system, the combination of all 6 GOCE gradients and additionally the consistent combination with other gravity observations mean an innovative challenge for regional gravity field modelling. As the individual gravity gradients reflect the gravity field depending on different spatial directions, observation equations are formulated separately for each of these components. In our approach we use spherical localizing base functions to display the gravity field for specified regions. Therefore the series expansions based on Legendre polynomials have to be adopted to obtain mathematical expressions for the second derivatives of the gravitational potential which are observed by GOCE in the Cartesian Gradiometer Reference Frame (GRF). We (1) have to transform the equations from the spherical terrestrial into a Cartesian Local North-Oriented Reference Frame (LNOF), (2) to set up a 3x3 tensor of observation equations and (3) finally to rotate the tensor defined in the terrestrial LNOF into the GRF. Thus we ensure the use of the original non-rotated and unaffected GOCE measurements within the analysis procedure. As output from the synthesis procedure we then obtain the second derivatives of the gravitational potential for all combinations of the xyz Cartesian coordinates in the LNOF. Further the implementation of variance component estimation provides a flexible tool to diversify the influence of the input gradiometer observations. On the one hand the less accurate xy and yz measurements are nearly excluded by estimating large variance components. On the other hand the yy measurements, which show systematic errors increasing at high latitudes, could be manually down-weighted in the corresponding regions. We choose different test areas to compute regional gravity field models at mean GOCE altitudes for different spectral resolutions and varying relative weights for the observations. Further we compare the regional models with the static global GOCO03S model. Especially the flexible handling and combination of the 3D measurements promise a great benefit for geophysical applications from GOCE gravity gradients, as they contain information on radial as well as on lateral gravity changes.

Using the Full Cycle of GOCE Data in the Quasi-Geoid Modelling of Finland

NASA Astrophysics Data System (ADS)

Saari, Timo; Bilker-Koivula, Mirjam; Poutanen, Markku

2016-08-01

In the Dragon 3 project 10519 "Case study on heterogeneous geoid/quasigeoid based on space borne and terrestrial data combination with special consideration of GOCE mission data impact" we combined the latest GOCE models with the terrestrial gravity data of Finland and surrounding areas to calculate a quasi-geoid model for Finland. Altogether 249 geoid models with different modifications were calculated using the GOCE DIR5 models up to spherical harmonic degree and order 240 and 300 and the EIGEN-6C4 up to degree and order 1000 and 2190.The calculated quasi-geoid models were compared against the ground truth in Finland with two independent GPS-levelling datasets. The best GOCE- only models gave standard deviations of 2.8 cm, 2.6 cm (DIR5 d/o 240) and 2.7 cm, 2.3 cm (DIR5 d/o 300) in Finnish territory for NLS-FIN and EUVN-DA datasets, respectively. For the high resolution model EIGEN-6C4 (which includes the full cycle of the GOCE data), the results were 2.4 cm, 1.8 cm (d/o 1000) and 2.5 cm, 1.7 (d/o 2190). The sub-2-centimetre (and near 2 cm with GOCE-only) accuracy is an improvement over the previous and current Finnish geoid models, thus leading to a conclusion of the great impact of the GOCE- mission on regional geoid modelling.

Precise Orbit Determination Of Low Earth Satellites At AIUB Using GPS And SLR Data

NASA Astrophysics Data System (ADS)

Jaggi, A.; Bock, H.; Thaller, D.; Sosnica, K.; Meyer, U.; Baumann, C.; Dach, R.

2013-12-01

An ever increasing number of low Earth orbiting (LEO) satellites is, or will be, equipped with retro-reflectors for Satellite Laser Ranging (SLR) and on-board receivers to collect observations from Global Navigation Satellite Systems (GNSS) such as the Global Positioning System (GPS) and the Russian GLONASS and the European Galileo systems in the future. At the Astronomical Institute of the University of Bern (AIUB) LEO precise orbit determination (POD) using either GPS or SLR data is performed for a wide range of applications for satellites at different altitudes. For this purpose the classical numerical integration techniques, as also used for dynamic orbit determination of satellites at high altitudes, are extended by pseudo-stochastic orbit modeling techniques to efficiently cope with potential force model deficiencies for satellites at low altitudes. Accuracies of better than 2 cm may be achieved by pseudo-stochastic orbit modeling for satellites at very low altitudes such as for the GPS-based POD of the Gravity field and steady-state Ocean Circulation Explorer (GOCE).

Investigating TIME-GCM Atmospheric Tides for Different Lower Boundary Conditions

NASA Astrophysics Data System (ADS)

Haeusler, K.; Hagan, M. E.; Lu, G.; Forbes, J. M.; Zhang, X.; Doornbos, E.

2013-12-01

It has been recently established that atmospheric tides generated in the lower atmosphere significantly influence the geospace environment. In order to extend our knowledge of the various coupling mechanisms between the different atmospheric layers, we rely on model simulations. Currently there exist two versions of the Global Scale Wave Model (GSWM), i.e. GSWM02 and GSWM09, which are used as a lower boundary (ca. 30 km) condition for the Thermosphere-Ionosphere-Mesosphere-Electrodynamics General Circulation Model (TIME-GCM) and account for the upward propagating atmospheric tides that are generated in the troposphere and lower stratosphere. In this paper we explore the various TIME-GCM upper atmospheric tidal responses for different lower boundary conditions and compare the model diagnostics with tidal results from satellite missions such as TIMED, CHAMP, and GOCE. We also quantify the differences between results associated with GSWM02 and GSWM09 forcing and results of TIMEGCM simulations using Modern-Era Retrospective Analysis for Research and Application (MERRA) data as a lower boundary condition.

First look at GOCE-derived thermosphere density and wind measurements

NASA Astrophysics Data System (ADS)

Doornbos, E.; Bruinsma, S. L.; Koppenwallner, G.; Fritsche, B.; Visser, P. N.; van den IJssel, J.; Kern, M.

2011-12-01

Accelerometers carried by low-Earth orbiters such as GOCE have the ability to provide highly detailed data on thermospheric density and winds. Like its predecessor missions, CHAMP and GRACE, GOCE has not been specifically designed for studies of the thermosphere. Nevertheless, their application in this domain has resulted in density and wind data sets containing information at unprecedented levels of coverage and precision, resulting in many scientific papers. The orbit of GOCE is unique. It is nearly sun-synchronous, and due to its drag free control system, its altitude can be kept fixed for several years, at about 270 km. This leads to sampling characteristics that are ideal for studying the effect of variations in solar and magnetospheric energy input on the thermosphere density and wind. Besides the presentation of the first GOCE-derived density and wind measurements, this poster will describe the GOCE data processing approach, which differs from that of the earlier missions in the special consideration required for both the handling of the thruster accelerations and the aerodynamic modelling.

What have we gained from GOCE, and what is still to be expected?

NASA Astrophysics Data System (ADS)

Pail, R.; Fecher, T.; Mayer-Gürr, T.; Rieser, D.; Schuh, W. D.; Brockmann, J. M.; Jäggi, A.; Höck, E.

2012-04-01

So far three releases of GOCE-only gravity field models applying the time-wise method have been computed in the frame of the ESA project "GOCE High-Level Processing Facility". They have been complemented by satellite-only combination models generated by the GOCO ("Gravity Observation Combination") consortium. Due to the fact that the processing strategy has remained practically unchanged for all releases, the continuous improvement by including more and more GOCE data can be analyzed. One of the basic features of the time-wise gravity field models (GOCE_TIM) is the fact, that no gravity field prior information is used, neither as reference model nor for constraining the solution. Therefore, the gain of knowledge on the Earth's gravity field derived purely from the GOCE mission can be evaluated. The idea of the complementary GOCO models is to improve the long to medium wavelengths of the gravity field solutions, which are rather weakly defined by GOCE orbit information, by inclusion of additional data from satellite sources such as GRACE, CHAMP and SLR, taking benefit from the individual strengths and favourable features of the individual data types. In this contribution, we will review which impact GOCE has achieved so far on global and regional gravity field modelling. Besides the gravity field modelling itself, the contributions of GOCE to several application fields, such as the computation of geodetic mean dynamic topography (MDT), and also for geophysical modelling of the lithosphere, will be highlighted. Special emphasis shall be given to the discussion to what extent the full variance-covariance information, representing very realistic error estimates of the gravity field accuracy, can be utilized. Finally, also a GOCE performance prediction shall be given. After the end of the extended mission phase by December 2012, currently several mission scenarios are discussed, such as either extending the mission period further as long as possible at the same altitude, or lowering the satellite by 10-20 km for a shorter period. Based on numerical simulation studies the pros and cons of several scenarios regarding the achievable gravity field accuracy shall be evaluated and quantified.

Evaluation of the Geopotential value for the Local Vertical Datum of China using GRACE/GOCE GGMs and GPS/Leveling Data

NASA Astrophysics Data System (ADS)

He, Lin; Li, Jiancheng; Chu, Yonghai; Zhang, Tengxu

2017-04-01

National height reference systems have conventionally been linked to the coastal local mean sea level, observed at one tide gauge, such as the China national height datum 1985. Due to the effect of the local sea surface topography, the reference level surface of local datum is inconsistent with the global datum or other local datum. In order to unify or connect the local datum to the global height datum, it is necessary to obtain the zero-height geopotential value of local datum or the height offset with respect to the global datum. The GRACE and GOCE satellite mission are promising for purposes of unification of local vertical datums because they have brought a significant improvement in modeling of low-frequency or rather medium-frequency part of the Earth's static gravity field in the past ten years. The focus of this work is directed to the evaluation of most available Global Geopotential Models (GGMs) from GOCE and GRACE, both satellite only as well as combined ones. From the evaluation with the 649 GPS/Levelling benchmarks (BMs) in China, the GOCE/GRACE GGMs provide the accuracy at 42-52cm level, up to their max degree and order. The latest release 5 DIR, TIM GGMs improve the accuracies by 6-10cm compared to the release 1 models. The DIR_R1 is based on the fewer GOCE data performs equally well with the DIR_R4 and DIR_R5 model, this is attributed to the fact that during its development which used a priori information from EIGEN-51C. The zero-height geopotential value W0LVD for the China Local Vertical Datum (LVD) is 62636855.1606m2s-2 from the originally GOCE/GRACE GGMs. Taking into account the GPS/Levelling data contains the full spectral information, and the GOCE-only or GRACE-GOCE combined model are limited to the long wavelengths. To improve the accuracy of the GGMs, it is indispensable to account for the remaining signal above this maximum degree, known as the omission error of the GGM. The effect of GRACE/GOCE omission error is investigated by extending the models with the high-resolution gravity field model EGM2008. In China, the effect of the GRACE/GOCE GGMs omission error is at the decimeter level. The combined GGMs (up to 2160 degree and order) could provide an accuracy at 20cm level, which is better than that from EGM2008. Meanwhile, if an appropriate degree and order is chosen for the GOCE-only or GRACE-GOCE combined GGMs to connect with the EGM2008, the extended GGMs provide an accuracy at 16cm level. From the extended GGMs, the geopotential value W0LVD determined for the China local vertical datum is 62636853.4351 m2s-2 indicates a bias of about 2.5649 m2/s-2 compared to the conventional value of 62,636,856.0 m2s-2. This is support by National key research and development program No:2016YFB0501702. Keywords: Global Geopotential Models; GRACE; GOCE; GPS/Levelling; zero-height geopotential

High-frequency analysis of Earth gravity field models based on terrestrial gravity and GPS/levelling data: a case study in Greece

NASA Astrophysics Data System (ADS)

Papanikolaou, T. D.; Papadopoulos, N.

2015-06-01

The present study aims at the validation of global gravity field models through numerical investigation in gravity field functionals based on spherical harmonic synthesis of the geopotential models and the analysis of terrestrial data. We examine gravity models produced according to the latest approaches for gravity field recovery based on the principles of the Gravity field and steadystate Ocean Circulation Explorer (GOCE) and Gravity Recovery And Climate Experiment (GRACE) satellite missions. Furthermore, we evaluate the overall spectrum of the ultra-high degree combined gravity models EGM2008 and EIGEN-6C3stat. The terrestrial data consist of gravity and collocated GPS/levelling data in the overall Hellenic region. The software presented here implements the algorithm of spherical harmonic synthesis in a degree-wise cumulative sense. This approach may quantify the bandlimited performance of the individual models by monitoring the degree-wise computed functionals against the terrestrial data. The degree-wise analysis performed yields insight in the short-wavelengths of the Earth gravity field as these are expressed by the high degree harmonics.

Structure and State of Stress of the Chilean Subduction Zone from Terrestrial and Satellite-Derived Gravity and Gravity Gradient Data

NASA Astrophysics Data System (ADS)

Gutknecht, B. D.; Götze, H.-J.; Jahr, T.; Jentzsch, G.; Mahatsente, R.; Zeumann, St.

2014-11-01

It is well known that the quality of gravity modelling of the Earth's lithosphere is heavily dependent on the limited number of available terrestrial gravity data. More recently, however, interest has grown within the geoscientific community to utilise the homogeneously measured satellite gravity and gravity gradient data for lithospheric scale modelling. Here, we present an interdisciplinary approach to determine the state of stress and rate of deformation in the Central Andean subduction system. We employed gravity data from terrestrial, satellite-based and combined sources using multiple methods to constrain stress, strain and gravitational potential energy (GPE). Well-constrained 3D density models, which were partly optimised using the combined regional gravity model IMOSAGA01C (Hosse et al. in Surv Geophys, 2014, this issue), were used as bases for the computation of stress anomalies on the top of the subducting oceanic Nazca plate and GPE relative to the base of the lithosphere. The geometries and physical parameters of the 3D density models were used for the computation of stresses and uplift rates in the dynamic modelling. The stress distributions, as derived from the static and dynamic modelling, reveal distinct positive anomalies of up to 80 MPa along the coastal Jurassic batholith belt. The anomalies correlate well with major seismicity in the shallow parts of the subduction system. Moreover, the pattern of stress distributions in the Andean convergent zone varies both along the north-south and west-east directions, suggesting that the continental fore-arc is highly segmented. Estimates of GPE show that the high Central Andes might be in a state of horizontal deviatoric tension. Models of gravity gradients from the Gravity field and steady-state Ocean Circulation Explorer (GOCE) satellite mission were used to compute Bouguer-like gradient anomalies at 8 km above sea level. The analysis suggests that data from GOCE add significant value to the interpretation of lithospheric structures, given that the appropriate topographic correction is applied.

The Role of the Upper Atmosphere for Dawn-Dusk and Interhemispheric Differences in the Coupled Magnetosphere-Ionosphere-Thermosphere System

NASA Astrophysics Data System (ADS)

Foerster, M.; Doornbos, E.; Haaland, S.

2016-12-01

Solar wind and IMF interaction with the geomagnetic field sets up a large-scale plasma circulation in the Earth's magnetosphere and the magnetically tightly connected ionosphere. The ionospheric ExB ion drift at polar latitudes accelerates the neutral gas as a nondivergent momentum source primarily in force balance with pressure gradients, while the neutral upper thermosphere circulation is essentially modified by apparent forces due to Earth's rotation (Coriolis and centrifugal forces) as well as advection and viscous forces. The apparent forces affect the dawn and dusk side asymmetrically, favouring a large dusk-side neutral wind vortex, while the non-dipolar portions of the Earth's magnetic field constitute significant hemispheric differences in magnetic flux and field configurations that lead to essential interhemispheric differences of the ion-neutral interaction. We present statistical studies of both the high-latitude ionospheric convection and the upper thermospheric circulation patterns based on measurements of the electron drift instrument (EDI) on board the Cluster satellites and by the accelerometer on board the CHAMP, GOCE, and Swarm spacecraft, respectively.

EUPOS and SLR Contribution to GOCE Mission

NASA Astrophysics Data System (ADS)

Balodis, J.; Caunite, M.; Janpaule, I.; Kenyeres, A.; Rubans, A.; Silabriedis, G.; Rosenthal, G.; Zarinsjh, A.; Zvirgzds, J.; Abel, M.

2010-12-01

After the interest of geodesists from several East European countries on successful use of SAPOS in Germany the European Position Determination System EUPOS® project has been established at 2002 under the leadership of Gerd Rosenthal, Berlin State Department of Urban Development. Currently the ground based GNSS augmentation system EUPOS® sub-networks has been developed successfully in 17 countries and the wish to join has been expressed by several other countries. EUPOS® is widely used in many practical applications. Two proposals - "EUPOS® Contribution to GOCE Mission" (Id 4307), "GOCE Observations using SLR for LEO satellites" (Id 4333), were submitted to ESA when ESA in autumn 2006 invited research people to submit proposals for GOCE mission applications. The report is presented in this article on the work which has been done in EUPOS® community and at the University of Latvia. During last 3 years the EUPOS® sub- networks has been completed (Poland, Lithuania, Slovakia, Bulgaria, they tied to the National levelling networks, detailed system behaviour has been depicted on the bases of EUPOS®-Riga network. The development of the SLR for LEO satellites is presented. Initially it was developed for GOCE spacecraft positioning. However, SLR till now was able to observe satellites at night.

Improving GOCE cross-track gravity gradients

NASA Astrophysics Data System (ADS)

Siemes, Christian

2018-01-01

The GOCE gravity gradiometer measured highly accurate gravity gradients along the orbit during GOCE's mission lifetime from March 17, 2009, to November 11, 2013. These measurements contain unique information on the gravity field at a spatial resolution of 80 km half wavelength, which is not provided to the same accuracy level by any other satellite mission now and in the foreseeable future. Unfortunately, the gravity gradient in cross-track direction is heavily perturbed in the regions around the geomagnetic poles. We show in this paper that the perturbing effect can be modeled accurately as a quadratic function of the non-gravitational acceleration of the satellite in cross-track direction. Most importantly, we can remove the perturbation from the cross-track gravity gradient to a great extent, which significantly improves the accuracy of the latter and offers opportunities for better scientific exploitation of the GOCE gravity gradient data set.

The IfE Global Gravity Field Model Recovered from GOCE Orbit and Gradiometer Data

NASA Astrophysics Data System (ADS)

Wu, Hu; Muiller, Jurgen; Brieden, Phillip

2015-03-01

An independent global gravity field model is computed from the GOCE orbit and gradiometer data using our own IfE software. We analysed the same data period that were considered for the first released GOCE models. The Acceleration Approach is applied to process the orbit data. The gravity gradients are processed in the framework of the remove-restore technique by which the low-frequency noise of the original gradients are removed. For the combined solution, the normal equations are summed by the Variance Component Estimation Approach. The result in terms of accumulated geoid height error calculated from the coefficient difference w.r.t. EGM2008 is about 11 cm at D/O 200, which corresponds to the accuracy level of the first released TIM and DIR solutions. This indicates that our IfE model has a comparable performance as the other official GOCE models.

A Least Squares Collocation Approach with GOCE gravity gradients for regional Moho-estimation

NASA Astrophysics Data System (ADS)

Rieser, Daniel; Mayer-Guerr, Torsten

2014-05-01

The depth of the Moho discontinuity is commonly derived by either seismic observations, gravity measurements or combinations of both. In this study, we aim to use the gravity gradient measurements of the GOCE satellite mission in a Least Squares Collocation (LSC) approach for the estimation of the Moho depth on regional scale. Due to its mission configuration and measurement setup, GOCE is able to contribute valuable information in particular in the medium wavelengths of the gravity field spectrum, which is also of special interest for the crust-mantle boundary. In contrast to other studies we use the full information of the gradient tensor in all three dimensions. The problem outline is formulated as isostatically compensated topography according to the Airy-Heiskanen model. By using a topography model in spherical harmonics representation the topographic influences can be reduced from the gradient observations. Under the assumption of constant mantle and crustal densities, surface densities are directly derived by LSC on regional scale, which in turn are converted in Moho depths. First investigations proofed the ability of this method to resolve the gravity inversion problem already with a small amount of GOCE data and comparisons with other seismic and gravitmetric Moho models for the European region show promising results. With the recently reprocessed GOCE gradients, an improved data set shall be used for the derivation of the Moho depth. In this contribution the processing strategy will be introduced and the most recent developments and results using the currently available GOCE data shall be presented.

GOCE User Toolbox and Tutorial

NASA Astrophysics Data System (ADS)

Benveniste, Jérôme; Knudsen, Per

2016-07-01

The GOCE User Toolbox GUT is a compilation of tools for the utilisation and analysis of GOCE Level 2 products. GUT support applications in Geodesy, Oceanography and Solid Earth Physics. The GUT Tutorial provides information and guidance in how to use the toolbox for a variety of applications. GUT consists of a series of advanced computer routines that carry out the required computations. It may be used on Windows PCs, UNIX/Linux Workstations, and Mac. The toolbox is supported by The GUT Algorithm Description and User Guide and The GUT Install Guide. A set of a-priori data and models are made available as well. Without any doubt the development of the GOCE user toolbox have played a major role in paving the way to successful use of the GOCE data for oceanography. The GUT version 2.2 was released in April 2014 and beside some bug-fixes it adds the capability for the computation of Simple Bouguer Anomaly (Solid-Earth). During this fall a new GUT version 3 has been released. GUTv3 was further developed through a collaborative effort where the scientific communities participate aiming on an implementation of remaining functionalities facilitating a wider span of research in the fields of Geodesy, Oceanography and Solid earth studies. Accordingly, the GUT version 3 has: - An attractive and easy to use Graphic User Interface (GUI) for the toolbox, - Enhance the toolbox with some further software functionalities such as to facilitate the use of gradients, anisotropic diffusive filtering and computation of Bouguer and isostatic gravity anomalies. - An associated GUT VCM tool for analyzing the GOCE variance covariance matrices.

Regional Recovery of the Disturbing Gravitational Potential from Satellite Observations of First-, Second- and Third-order Radial Derivatives of the Disturbing Gravitational Potential

NASA Astrophysics Data System (ADS)

Novak, P.; Pitonak, M.; Sprlak, M.

2015-12-01

Recently realized gravity-dedicated satellite missions allow for measuring values of scalar, vectorial (Gravity Recovery And Climate Experiment - GRACE) and second-order tensorial (Gravity field and steady-state Ocean Circulation Explorer - GOCE) parameters of the Earth's gravitational potential. Theoretical aspects related to using moving sensors for measuring elements of a third-order gravitational tensor are currently under investigation, e.g. the gravity-dedicated satellite mission OPTIMA (OPTical Interferometry for global Mass change detection from space) should measure third-order derivatives of the Earth's gravitational potential. This contribution investigates regional recovery of the disturbing gravitational potential on the Earth's surface from satellite observations of first-, second- and third-order radial derivatives of the disturbing gravitational potential. Synthetic measurements along a satellite orbit at the altitude of 250 km are synthetized from the global gravitational model EGM2008 and polluted by the Gaussian noise. The process of downward continuation is stabilized by the Tikhonov regularization. Estimated values of the disturbing gravitational potential are compared with the same quantity synthesized directly from EGM2008. Finally, this contribution also discusses merging a regional solution into a global field as a patchwork.

Possibilities of the regional gravity field recovery from first-, second- and third-order radial derivatives of the disturbing gravitational potential measured on moving platforms

NASA Astrophysics Data System (ADS)

Pitonak, Martin; Sprlak, Michal; Novak, Pavel; Tenzer, Robert

2016-04-01

Recently realized gravity-dedicated satellite missions allow for measuring values of scalar, vectorial (Gravity Recovery And Climate Experiment - GRACE) and second-order tensorial (Gravity field and steady-state Ocean Circulation Explorer - GOCE) parameters of the Earth's gravitational potential. Theoretical aspects related to using moving sensors for measuring elements of the third-order gravitational tensor are currently under investigation, e.g., the gravity field-dedicated satellite mission OPTIMA (OPTical Interferometry for global Mass change detection from space) should measure third-order derivatives of the Earth's gravitational potential. This contribution investigates regional recovery of the disturbing gravitational potential on the Earth's surface from satellite and aerial observations of the first-, second- and third-order radial derivatives of the disturbing gravitational potential. Synthetic measurements along a satellite orbit at the altitude of 250 km and along an aircraft track at the altitude of 10 km are synthetized from the global gravitational model EGM2008 and polluted by the Gaussian noise. The process of downward continuation is stabilized by the Tikhonov regularization. Estimated values of the disturbing gravitational potential are compared with the same quantity synthesized directly from EGM2008.

Slab Geometry and Segmentation on Seismogenic Subduction Zone; Insight from gravity gradients

NASA Astrophysics Data System (ADS)

Saraswati, A. T.; Mazzotti, S.; Cattin, R.; Cadio, C.

2017-12-01

Slab geometry is a key parameter to improve seismic hazard assessment in subduction zones. In many cases, information about structures beneath subduction are obtained from geophysical dedicated studies, including geodetic and seismic measurements. However, due to the lack of global information, both geometry and segmentation in seismogenic zone of many subductions remain badly-constrained. Here we propose an alternative approach based on satellite gravity observations. The GOCE (Gravity field and steady-state Ocean Circulation Explorer) mission enables to probe Earth deep mass structures from gravity gradients, which are more sensitive to spatial structure geometry and directional properties than classical gravitational data. Gravity gradients forward modeling of modeled slab is performed by using horizontal and vertical gravity gradient components to better determine slab geophysical model rather than vertical gradient only. Using polyhedron method, topography correction on gravity gradient signal is undertaken to enhance the anomaly signal of lithospheric structures. Afterward, we compare residual gravity gradients with the calculated signals associated with slab geometry. In this preliminary study, straightforward models are used to better understand the characteristic of gravity gradient signals due to deep mass sources. We pay a special attention to the delineation of slab borders and dip angle variations.

Global grids of gravity anomalies and vertical gravity gradients at 10 km altitude from GOCE gradient data 2009-2011 and polar gravity.

NASA Astrophysics Data System (ADS)

Tscherning, Carl Christian; Arabelos, Dimitrios; Reguzzoni, Mirko

2013-04-01

The GOCE satellite measures gravity gradients which are filtered and transformed to gradients into an Earth-referenced frame by the GOCE High Level processing Facility. More than 80000000 data with 6 components are available from the period 2009-2011. IAG Arctic gravity was used north of 83 deg., while data at the Antarctic was not used due to bureaucratic restrictions by the data-holders. Subsets of the data have been used to produce gridded values at 10 km altitude of gravity anomalies and vertical gravity gradients in 20 deg. x 20 deg. blocks with 10' spacing. Various combinations and densities of data were used to obtain values in areas with known gravity anomalies. The (marginally) best choice was vertical gravity gradients selected with an approximately 0.125 deg spacing. Using Least-Squares Collocation, error-estimates were computed and compared to the difference between the GOCE-grids and grids derived from EGM2008 to deg. 512. In general a good agreement was found, however with some inconsistencies in certain areas. The computation time on a usual server with 24 processors was typically 100 minutes for a block with generally 40000 GOCE vertical gradients as input. The computations will be updated with new Wiener-filtered data in the near future.

Moho topography, ranges and folds of Tibet by analysis of global gravity models and GOCE data

PubMed Central

Shin, Young Hong; Shum, C.K.; Braitenberg, Carla; Lee, Sang Mook; Na, Sung -Ho; Choi, Kwang Sun; Hsu, Houtse; Park, Young-Sue; Lim, Mutaek

2015-01-01

The determination of the crustal structure is essential in geophysics, as it gives insight into the geohistory, tectonic environment, geohazard mitigation, etc. Here we present the latest advance on three-dimensional modeling representing the Tibetan Mohorovičić discontinuity (topography and ranges) and its deformation (fold), revealed by analyzing gravity data from GOCE mission. Our study shows noticeable advances in estimated Tibetan Moho model which is superior to the results using the earlier gravity models prior to GOCE. The higher quality gravity field of GOCE is reflected in the Moho solution: we find that the Moho is deeper than 65 km, which is twice the normal continental crust beneath most of the Qinghai-Tibetan plateau, while the deepest Moho, up to 82 km, is located in western Tibet. The amplitude of the Moho fold is estimated to be ranging from −9 km to 9 km with a standard deviation of ~2 km. The improved GOCE gravity derived Moho signals reveal a clear directionality of the Moho ranges and Moho fold structure, orthogonal to deformation rates observed by GPS. This geophysical feature, clearly more evident than the ones estimated using earlier gravity models, reveals that it is the result of the large compressional tectonic process. PMID:26114224

Crust-mantle density distribution in the eastern Qinghai-Tibet Plateau revealed by satellite-derived gravity gradients

NASA Astrophysics Data System (ADS)

LI, Honglei; Fang, Jian; Braitenberg, Carla; Wang, Xinsheng

2015-04-01

As the highest, largest and most active plateau on Earth, the Qinghai-Tibet Plateau has a complex crust-mantle structure, especially in its eastern part. In response to the subduction of the lithospheric mantle of the Indian plate, large-scale crustal motion occurs in this area. Despite the many previous studies, geodynamic processes at depth remain unclear. Knowledge of crust and upper mantle density distribution allows a better definition of the deeper geological structure and thus provides critically needed information for understanding of the underlying geodynamic processes. With an unprecedented precision of 1-2 mGal and a spatial resolution better than 100 km, GOCE (Gravity field and steady-state Ocean Circulation Explorer) mission products can be used to constrain the crust-mantle density distribution. Here we used GOCE gravitational gradients at an altitude of 10km after reducing the effects of terrain, sediment thickness variations, and Moho undulations to image the density structures of eastern Tibet up to 200 km depths. We inverted the residual satellite gravitational gradients using a least square approach. The initial density model for the inversion is based on seismic velocities from the tomography. The model is composed of rectangular blocks, having a uniform density, with widths of about 100 km and variable thickness and depths. The thickness of the rectangular cells changes from10 to 60km in accordance with the seismic model. Our results reveal some large-scale, structurally controlled density variations at depths. The lithospheric root defined by higher-density contrast features from southwest to northeast, with shallowing in the central part: base of lithosphere reaches a depth of180 km, less than 100km, and 200 km underneath the Lhasa, Songpan-Ganzi, and Ordos crustal blocks, respectively. However, these depth values only represent a first-order parameterization because they depend on model discretization inherited from the original seismic tomography model. For example, the thickness of the uniform density blocks centered at140 km depth is as large as 60 km. Low-density crustal anomalies beneath the southern Lhasa and Songpan-Ganzi blocks in our model support the idea of weak lower crust and possible crustal flow, as a result of the thermal anomalies caused by the upwelling of hot deep materials. The weak lower crust may cause the decoupling of the upper crust and the mantle. These results are consistent with many other geophysical studies, confirming the effectiveness of the GOCE gravitational gradient data. Using these data in combination with other geodynamic constraints (e.g., gravity and seismic structure and preliminary reference Earth model), an improved dynamic model can be derived.

GOCE User Toolbox and Tutorial

NASA Astrophysics Data System (ADS)

Knudsen, Per; Benveniste, Jerome

2017-04-01

The GOCE User Toolbox GUT is a compilation of tools for the utilisation and analysis of GOCE Level 2 products.
GUT support applications in Geodesy, Oceanography and Solid Earth Physics. The GUT Tutorial provides information
and guidance in how to use the toolbox for a variety of applications. GUT consists of a series of advanced
computer routines that carry out the required computations. It may be used on Windows PCs, UNIX/Linux Workstations,
and Mac. The toolbox is supported by The GUT Algorithm Description and User Guide and The GUT
Install Guide. A set of a-priori data and models are made available as well. Without any doubt the development
of the GOCE user toolbox have played a major role in paving the way to successful use of the GOCE data for
oceanography. The GUT version 2.2 was released in April 2014 and beside some bug-fixes it adds the capability for the computation of Simple Bouguer Anomaly (Solid-Earth). During this fall a new GUT version 3 has been released. GUTv3 was further developed through a collaborative effort where the scientific communities participate aiming
on an implementation of remaining functionalities facilitating a wider span of research in the fields of Geodesy,
Oceanography and Solid earth studies.
Accordingly, the GUT version 3 has:
 - An attractive and easy to use Graphic User Interface (GUI) for the toolbox,
 - Enhance the toolbox with some further software functionalities such as to facilitate the use of gradients,
anisotropic diffusive filtering and computation of Bouguer and isostatic gravity anomalies.
 - An associated GUT VCM tool for analyzing the GOCE variance covariance matrices.

GOCE User Toolbox and Tutorial

NASA Astrophysics Data System (ADS)

Knudsen, Per; Benveniste, Jerome; Team Gut

2016-04-01

The GOCE User Toolbox GUT is a compilation of tools for the utilisation and analysis of GOCE Level 2 products.
GUT support applications in Geodesy, Oceanography and Solid Earth Physics. The GUT Tutorial provides information
and guidance in how to use the toolbox for a variety of applications. GUT consists of a series of advanced
computer routines that carry out the required computations. It may be used on Windows PCs, UNIX/Linux Workstations,
and Mac. The toolbox is supported by The GUT Algorithm Description and User Guide and The GUT
Install Guide. A set of a-priori data and models are made available as well. Without any doubt the development
of the GOCE user toolbox have played a major role in paving the way to successful use of the GOCE data for
oceanography. The GUT version 2.2 was released in April 2014 and beside some bug-fixes it adds the capability for the computation of Simple Bouguer Anomaly (Solid-Earth). During this fall a new GUT version 3 has been released. GUTv3 was further developed through a collaborative effort where the scientific communities participate aiming
on an implementation of remaining functionalities facilitating a wider span of research in the fields of Geodesy,
Oceanography and Solid earth studies.
Accordingly, the GUT version 3 has:
 - An attractive and easy to use Graphic User Interface (GUI) for the toolbox,
 - Enhance the toolbox with some further software functionalities such as to facilitate the use of gradients,
anisotropic diffusive filtering and computation of Bouguer and isostatic gravity anomalies.
 - An associated GUT VCM tool for analyzing the GOCE variance covariance matrices.

Gravity Field Solution Derived from Recent Releases of GOCE-Based Geopotential Models and Terrestrial Gravity Observations over The Kingdom of Saudi Arabia

NASA Astrophysics Data System (ADS)

Alothman, Abdulaziz; Elsaka, Basem

2015-03-01

The free air gravity anomalies over Saudi Arabia (KSA) has been estimated from the final releases of GOCE-based global geopotential models (GGMs) compared with the terrestrial gravity anomalies of 3554 sites. Two GGMs; EGM08 and Eigen-6C3 have been applied. The free-air anomalies from GOCE-based, ΔgGGM, have been calculated over the 3554 stations in the medium and short spectrum of gravity wavelength of d/o 100, …, 250 (with 10 step). The short spectrum has been compensated once from d/o 101, …, 251 to 2190 and 1949 using EGM08 and Eigen-6C3 (i.e. ΔgGGM), respectively. The very short component was determined using residual terrain modelling approach. Our findings show firstly that the EGM08 is more reliable than Eigen-6C3. Second, the GOCE-based GGMs provide similar results within the spectral wavelength band from d/o 100 to d/o 180. Beyond d/o 180 till d/o 250, we found that GOCE-based TIM model releases provide substantial improvements within the spectral band from d/o 220 to d/o 250 with respect to the DIR releases. Third, the TIM_r5 model provides the least standard deviations (st. dev.) in terms of gravity anomalies.

Acceleration Noise Considerations for Drag-free Satellite Geodesy Missions

NASA Astrophysics Data System (ADS)

Hong, S. H.; Conklin, J. W.

2016-12-01

The GRACE mission, which launched in 2002, opened a new era of satellite geodesy by providing monthly mass variation solutions with spatial resolution of less than 200 km. GRACE proved the usefulness of a low-low satellite-to-satellite tracking formation. Analysis of the GRACE data showed that the K-Band ranging system, which is used to measure the range between the two satellites, is the limiting factor for the precision of the solution. Consequently, the GRACE-FO mission, schedule for launch in 2017, will continue the work of GRACE, but will also test a new, higher precision laser ranging interferometer compared with the K-Band ranging system. Beyond GRACE-FO, drag-free systems are being considered for satellite geodesy missions. GOCE tested a drag-free attitude control system with a gravity gradiometer and showed improvements in the acceleration noise compensation compared to the electrostatic accelerometers used in GRACE. However, a full drag-free control system with a gravitational reference sensor has not yet been applied to satellite geodesy missions. More recently, this type of drag-free system was used in LISA Pathfinder, launched in 2016, with an acceleration noise performance two orders of magnitude better than that of GOCE. We explore the effects of drag-free performance in satellite geodesy missions similar to GRACE-FO by applying three different residual acceleration noises from actual space missions: GRACE, GOCE and LISA Pathfinder. Our solutions are limited to degree 60 spherical harmonic coefficients with biweekly time resolution. Our analysis shows that a drag-free system with acceleration noise performance comparable to GOCE and LISA-Pathfinder would greatly improve the accuracy of gravity solutions. In addition to these results, we also present the covariance shaping process used in the estimation. In the future, we plan to use actual acceleration noise data measured using the UF torsion pendulum. This apparatus is a ground facility at University of Florida used to test the performance of precision inertial sensors. We also plan to evaluate the importance of acceleration noise when a second inclined pair of satellites is included in the analysis, following the work of Weise in 2012, which showed that two satellite pairs decreased aliasing errors.

Integrated approach to estimate the ocean's time variable dynamic topography including its covariance matrix

NASA Astrophysics Data System (ADS)

Müller, Silvia; Brockmann, Jan Martin; Schuh, Wolf-Dieter

2015-04-01

The ocean's dynamic topography as the difference between the sea surface and the geoid reflects many characteristics of the general ocean circulation. Consequently, it provides valuable information for evaluating or tuning ocean circulation models. The sea surface is directly observed by satellite radar altimetry while the geoid cannot be observed directly. The satellite-based gravity field determination requires different measurement principles (satellite-to-satellite tracking (e.g. GRACE), satellite-gravity-gradiometry (GOCE)). In addition, hydrographic measurements (salinity, temperature and pressure; near-surface velocities) provide information on the dynamic topography. The observation types have different representations and spatial as well as temporal resolutions. Therefore, the determination of the dynamic topography is not straightforward. Furthermore, the integration of the dynamic topography into ocean circulation models requires not only the dynamic topography itself but also its inverse covariance matrix on the ocean model grid. We developed a rigorous combination method in which the dynamic topography is parameterized in space as well as in time. The altimetric sea surface heights are expressed as a sum of geoid heights represented in terms of spherical harmonics and the dynamic topography parameterized by a finite element method which can be directly related to the particular ocean model grid. Besides the difficult task of combining altimetry data with a gravity field model, a major aspect is the consistent combination of satellite data and in-situ observations. The particular characteristics and the signal content of the different observations must be adequately considered requiring the introduction of auxiliary parameters. Within our model the individual observation groups are combined in terms of normal equations considering their full covariance information; i.e. a rigorous variance/covariance propagation from the original measurements to the final product is accomplished. In conclusion, the developed integrated approach allows for estimating the dynamic topography and its inverse covariance matrix on arbitrary grids in space and time. The inverse covariance matrix contains the appropriate weights for model-data misfits in least-squares ocean model inversions. The focus of this study is on the North Atlantic Ocean. We will present the conceptual design and dynamic topography estimates based on time variable data from seven satellite altimeter missions (Jason-1, Jason-2, Topex/Poseidon, Envisat, ERS-2, GFO, Cryosat2) in combination with the latest GOCE gravity field model and in-situ data from the Argo floats and near-surface drifting buoys.

Evaluation of global satellite gravity models using terrestrial gravity observations over the Kingdom of Saudi Arabia A. Alothman and B. Elsaka

NASA Astrophysics Data System (ADS)

Alothman, Abdulaziz; Elsaka, Basem

The gravity field models from the GRACE and GOCE missions have increased the knowledge of the earth’s global gravity field. The latter GOCE mission has provided accuracies of about 1-2 cm and 1milli-Gal level in the global geoid and gravity anomaly, respectively. However, determining all wavelength ranges of the gravity field spectrum cannot be only achieved from satellite gravimetry but from the allowed terrestrial gravity data. In this contribution, we use a gravity network of 42 first-order absolute gravity stations, observed by LaCosta Romberg gravimeter during the period 1967-1969 by Ministry of Petroleum and Mineral Resources, to validate the GOCE gravity models in order to gain more detailed regional gravity information. The network stations are randomly distributed all over the country with a spacing of about 200 km apart. The results show that the geoid height and gravity anomaly determined from terrestrial gravity data agree with the GOCE based models and give additional information to the satellite gravity solutions.

High rate GPS positioning , JASON altimetry and marine gravimetry : monitoring the Antarctic Circumpolar Current (ACC) through the DRAKE campaigns.

NASA Astrophysics Data System (ADS)

Melachroinos, S. A.; Biancale, R.; Menard, Y.; Sarrailh, M.

2008-12-01

The Drake campaign which took place from Jan 14, 2006 - 08 Feb, 2006 has been a very successful mission in collecting a wide range of GPS and marine gravity data all along JASON altimetry ground track n° 104. The same campaign will be repeated in 2009 along 028 and 104 JASON-2 ground track. The Drake Passage (DP) chokepoint is not only well suited geographically, as the Antarctic Circumpolar Current (ACC) is constricted to its narrowest extent of 700 km, but observations and models suggest that dynamical balances are particular effective in this area. Furthermore the space geodesy observations and their products provided from several altimetry missions (currently operating ENVISAT, JASON 1 and 2, GFO, ERS and other plannified for the future such as Altika, SWOT) require the cross comparison with independent geodetic techniques at the DP. The current experiment comprises a kinematic GPS and marine gravimetry Cal/Val geodetic approach and it aims to : validate with respect to altimetry data and surface models such a kinematic high frequency GPS technique for measuring sea state and sea surface height (SSH), compare the GPS SSH profiles with altimetry mean dynamic topography (MDT) and mean sea surface (MSS) models, give recommendations for future "offshore" Cal/Val activities on the ground tracks of altimeter satellites such as JASON-2, GFO, Altika using the GNSS technology etc. The GPS observations are collected from GPS antennas installed on a wave-rider buoy , aboard the R/V "Polarstern" and from continuous geodetic reference stations in the proximity. We also analyse problems related to the ship's attitude variations in roll, pitch and yaw and a way to correct them. We also give emphasis on the impact of the ship's acceleration profiles on the so called "squat effect" and ways to deal with it. The project will in particular benefit the GOCE mission by proposing to integrate GOCE in the ocean circulation study and validate GOCE products with our independent geodetic data set. The high rate GPS SSH solutions are derived using two different GPS kinematic software, GINS (CNES) and TRACK (MIT).

Goce and Its Role in Combined Global High Resolution Gravity Field Determination

NASA Astrophysics Data System (ADS)

Fecher, T.; Pail, R.; Gruber, T.

2013-12-01

Combined high-resolution gravity field models serve as a mandatory basis to describe static and dynamic processes in system Earth. Ocean dynamics can be modeled referring to a high-accurate geoid as reference surface, solid earth processes are initiated by the gravity field. Also geodetic disciplines such as height system determination depend on high-precise gravity field information. To fulfill the various requirements concerning resolution and accuracy, any kind of gravity field information, that means satellite as well as terrestrial and altimetric gravity field observations have to be included in one combination process. A key role is here reserved for GOCE observations, which contribute with its optimal signal content in the long to medium wavelength part and enable a more accurate gravity field determination than ever before especially in areas, where no high-accurate terrestrial gravity field observations are available, such as South America, Asia or Africa. For our contribution we prepare a combined high-resolution gravity field model up to d/o 720 based on full normal equation including recent GOCE, GRACE and terrestrial / altimetric data. For all data sets, normal equations are set up separately, relative weighted to each other in the combination step and solved. This procedure is computationally challenging and can only be performed using super computers. We put special emphasis on the combination process, for which we modified especially our procedure to include GOCE data optimally in the combination. Furthermore we modified our terrestrial/altimetric data sets, what should result in an improved outcome. With our model, in which we included the newest GOCE TIM4 gradiometry results, we can show how GOCE contributes to a combined gravity field solution especially in areas of poor terrestrial data coverage. The model is validated by independent GPS leveling data in selected regions as well as computation of the mean dynamic topography over the oceans. Further, we analyze the statistical error estimates derived from full covariance propagation and compare them with the absolute validation with independent data sets.

Results from the ESA-funded project 'Height System Unification with GOCE'

NASA Astrophysics Data System (ADS)

Sideris, M. G.; Rangelova, E. V.; Gruber, T.; Rummel, R. F.; Woodworth, P. L.; Hughes, C. W.; Ihde, J.; Liebsch, G.; Schäfer, U.; Rülke, A.; Gerlach, C.; Haagmans, R.

2013-12-01

The paper summarizes the main results of a project, supported by the European Space Agency, whose main goal is to identify the impact of GOCE gravity field models on height system unification. In particular, the Technical University Munich, the University of Calgary and the National Oceanography Centre in Liverpool, together with the Bavarian Academy of Sciences, the Federal German Agency for Cartography and Geodesy, and the Geodetic Surveys of Canada, USA and Mexico, have investigated the role of GOCE-derived gravity and geoid models for regional and global height datum connection. GOCE provides three important components of height unification: highly accurate potential differences (geopotential numbers), a global geoid- or quasi-geoid-based reference surface for elevations that is independent of inaccuracies and inconsistencies of local and regional data, and a consistent way to refer to the same datum all the relevant gravimetric, topographic and oceanographic data. We introduce briefly the methodology that has been applied in order to unify height system in North America, North Atlantic Ocean and Europe, and present results obtained using the available GOCE-derived satellite-only geopotential models, and their combination with terrestrial data and ocean models. The effects of various factors, such as data noise, omission errors, indirect bias terms, ocean models and temporal variations, on height datum unification are also presented, highlighting their magnitude and importance in the estimation of offsets between vertical datums. Based on the experiences gained in this project, a general roadmap has been developed for height datum unification in regions with good, as well as poor, coverage in gravity and geodetic height and tide gauge control stations.

Precise Orbit Determination of the GOCE Re-Entry Phase

NASA Astrophysics Data System (ADS)

Gini, Francesco; Otten, Michiel; Springer, Tim; Enderle, Werner; Lemmens, Stijn; Flohrer, Tim

2015-03-01

During the last days of the GOCE mission, after the GOCE spacecraft ran out of fuel, it slowly decayed before finally re-entering the atmosphere on the 11th November 2013. As an integrated part of the AOCS, GOCE carried a GPS receiver that was in operations during the re-entry phase. This feature provided a unique opportunity for Precise Orbit Determination (POD) analysis. As part of the activities carried out by the Navigation Support Office (HSO-GN) at ESOC, precise ephemerides of the GOCE satellite have been reconstructed for the entire re-entry phase based on the available GPS observations of the onboard LAGRANGE receiver. All the data available from the moment the thruster was switched off on the 21st of October 2013 to the last available telemetry downlink on the 10th November 2013 have been processed, for a total of 21 daily arcs. For this period a dedicated processing sequence has been defined and implemented within the ESA/ESOC NAvigation Package for Earth Observation Satellites (NAPEOS) software. The computed results show a post-fit RMS of the GPS undifferenced carrier phase residuals (ionospheric-free linear combination) between 6 and 14 mm for the first 16 days which then progressively increases up to about 80 mm for the last available days. An orbit comparison with the Precise Science Orbits (PSO) generated at the Astronomical Institute of the University of Bern (AIUB, Bern, Switzerland) shows an average difference around 9 cm for the first 8 daily arcs and progressively increasing up to 17 cm for the following days. During this reentry phase (21st of October - 10th November 2013) a substantial drop in the GOCE altitude is observed, starting from about 230 km to 130 km where the last GPS measurements were taken. During this orbital decay an increment of a factor of 100 in the aerodynamic acceleration profile is observed. In order to limit the mis-modelling of the non-gravitational forces (radiation pressure and aerodynamic effects) the newly developed software ARPA (Aerodynamics and Radiation Pressure Analysis) has been adopted to compute the forces acting on GOCE. An overview of the software techniques and the results of its implementation is presented in this paper. The use of the ARPA modelling leads to an average reduction of the carrier phase post-fit RMS of about 2 mm and decrement of the difference with the PSO orbits of more than 1 cm.

ESA BRAT (Broadview Radar Altimetry Toolbox) and GUT (GOCE User Toolbox) toolboxes

NASA Astrophysics Data System (ADS)

Benveniste, J.; Ambrozio, A.; Restano, M.

2016-12-01

The Broadview Radar Altimetry Toolbox (BRAT) is a collection of tools designed to facilitate the processing of radar altimetry data from previous and current altimetry missions, including the upcoming Sentinel-3A L1 and L2 products. A tutorial is included providing plenty of use cases. BRAT's future release (4.0.0) is planned for September 2016. Based on the community feedback, the frontend has been further improved and simplified whereas the capability to use BRAT in conjunction with MATLAB/IDL or C/C++/Python/Fortran, allowing users to obtain desired data bypassing the data-formatting hassle, remains unchanged. Several kinds of computations can be done within BRAT involving the combination of data fields, that can be saved for future uses, either by using embedded formulas including those from oceanographic altimetry, or by implementing ad-hoc Python modules created by users to meet their needs. BRAT can also be used to quickly visualise data, or to translate data into other formats, e.g. from NetCDF to raster images. The GOCE User Toolbox (GUT) is a compilation of tools for the use and the analysis of GOCE gravity field models. It facilitates using, viewing and post-processing GOCE L2 data and allows gravity field data, in conjunction and consistently with any other auxiliary data set, to be pre-processed by beginners in gravity field processing, for oceanographic and hydrologic as well as for solid earth applications at both regional and global scales. Hence, GUT facilitates the extensive use of data acquired during GRACE and GOCE missions. In the current 3.0 version, GUT has been outfitted with a graphical user interface allowing users to visually program data processing workflows. Further enhancements aiming at facilitating the use of gradients, the anisotropic diffusive filtering, and the computation of Bouguer and isostatic gravity anomalies have been introduced. Packaged with GUT is also GUT's VCM (Variance-Covariance Matrix) tool for analysing GOCE's variance-covariance matrices. BRAT and GUT toolboxes can be freely downloaded, along with ancillary material, at https://earth.esa.int/brat and https://earth.esa.int/gut.

Contribution of the GOCE gradiometer components to regional gravity solutions

NASA Astrophysics Data System (ADS)

Naeimi, Majid; Bouman, Johannes

2017-05-01

The contribution of the GOCE gravity gradients to regional gravity field solutions is investigated in this study. We employ radial basis functions to recover the gravity field on regional scales over Amazon and Himalayas as our test regions. In the first step, four individual solutions based on the more accurate gravity gradient components Txx, Tyy, Tzz and Txz are derived. The Tzz component gives better solution than the other single-component solutions despite the less accuracy of Tzz compared to Txx and Tyy. Furthermore, we determine five more solutions based on several selected combinations of the gravity gradient components including a combined solution using the four gradient components. The Tzz and Tyy components are shown to be the main contributors in all combined solutions whereas the Txz adds the least value to the regional gravity solutions. We also investigate the contribution of the regularization term. We show that the contribution of the regularization significantly decreases as more gravity gradients are included. For the solution using all gravity gradients, regularization term contributes to about 5 per cent of the total solution. Finally, we demonstrate that in our test areas, regional gravity modelling based on GOCE data provide more reliable gravity signal in medium wavelengths as compared to pre-GOCE global gravity field models such as the EGM2008.

Effects of space weather on GOCE electrostatic gravity gradiometer measurements

NASA Astrophysics Data System (ADS)

Ince, E. Sinem; Pagiatakis, Spiros D.

2016-12-01

We examine the presence of residual nongravitational signatures in gravitational gradients measured by GOCE electrostatic gravity gradiometer. These signatures are observed over the magnetic poles during geomagnetically active days and can contaminate the trace of the gravitational gradient tensor by up to three to five times the expected noise level of the instrument (˜ 11 mE). We investigate these anomalies in the gradiometer measurements along many satellite tracks and examine possible causes using external datasets, such as interplanetary electric field measurements from the ACE (advanced composition explorer) and WIND spacecraft, and Poynting vector (flux) estimated from equivalent ionospheric currents derived from spherical elementary current systems over North America and Greenland. We show that the variations in the east-west and vertical electrical currents and Poynting vector components at the satellite position are highly correlated with the disturbances observed in the gradiometer measurements. The results presented in this paper reveal that the disturbances are due to intense ionospheric current variations that are enhanced by increased solar activity that causes a very dynamic drag environment. Moreover, successful modelling and removal of a high percentage of these disturbances are possible using external geomagnetic field observations.

The Space-Wise Global Gravity Model from GOCE Nominal Mission Data

NASA Astrophysics Data System (ADS)

Gatti, A.; Migliaccio, F.; Reguzzoni, M.; Sampietro, D.; Sanso, F.

2011-12-01

In the framework of the GOCE data analysis, the space-wise approach implements a multi-step collocation solution for the estimation of a global geopotential model in terms of spherical harmonic coefficients and their error covariance matrix. The main idea is to use the collocation technique to exploit the spatial correlation of the gravity field in the GOCE data reduction. In particular the method consists of an along-track Wiener filter, a collocation gridding at satellite altitude and a spherical harmonic analysis by integration. All these steps are iterated, also to account for the rotation between local orbital and gradiometer reference frame. Error covariances are computed by Montecarlo simulations. The first release of the space-wise approach was presented at the ESA Living Planet Symposium in July 2010. This model was based on only two months of GOCE data and partially contained a priori information coming from other existing gravity models, especially at low degrees and low orders. A second release was distributed after the 4th International GOCE User Workshop in May 2011. In this solution, based on eight months of GOCE data, all the dependencies from external gravity information were removed thus giving rise to a GOCE-only space-wise model. However this model showed an over-regularization at the highest degrees of the spherical harmonic expansion due to the combination technique of intermediate solutions (based on about two months of data). In this work a new space-wise solution is presented. It is based on all nominal mission data from November 2009 to mid April 2011, and its main novelty is that the intermediate solutions are now computed in such a way to avoid over-regularization in the final solution. Beyond the spherical harmonic coefficients of the global model and their error covariance matrix, the space-wise approach is able to deliver as by-products a set of spherical grids of potential and of its second derivatives at mean satellite altitude. These grids have an information content that is very similar to the original along-orbit data, but they are much easier to handle. In addition they are estimated by local least-squares collocation and therefore, although computed by a unique global covariance function, they could yield more information at local level than the spherical harmonic coefficients of the global model. For this reason these grids seem to be useful for local geophysical investigations. The estimated grids with their estimated errors are presented in this work together with proposals on possible future improvements. A test to compare the different information contents of the along-orbit data, the gridded data and the spherical harmonic coefficients is also shown.

Assessment and Improvement of GOCE based Global Geopotential Models Using Wavelet Decomposition

NASA Astrophysics Data System (ADS)

Erol, Serdar; Erol, Bihter; Serkan Isik, Mustafa

2016-07-01

The contribution of recent Earth gravity field satellite missions, specifically GOCE mission, leads significant improvement in quality of gravity field models in both accuracy and resolution manners. However the performance and quality of each released model vary not only depending on the spatial location of the Earth but also the different bands of the spectral expansion. Therefore the assessment of the global model performances with validations using in situ-data in varying territories on the Earth is essential for clarifying their exact performances in local. Beside of this, their spectral evaluation and quality assessment of the signal in each part of the spherical harmonic expansion spectrum is essential to have a clear decision for the commission error content of the model and determining its optimal degree, revealed the best results, as well. The later analyses provide also a perspective and comparison on the global behavior of the models and opportunity to report the sequential improvement of the models depending on the mission developments and hence the contribution of the new data of missions. In this study a review on spectral assessment results of the recently released GOCE based global geopotential models DIR-R5, TIM-R5 with the enhancement using EGM2008, as reference model, in Turkey, versus the terrestrial data is provided. Beside of reporting the GOCE mission contribution to the models in Turkish territory, the possible improvement in the spectral quality of these models, via decomposition that are highly contaminated by noise, is purposed. In the analyses the motivation is on achieving an optimal amount of improvement that rely on conserving the useful component of the GOCE signal as much as possible, while fusing the filtered GOCE based models with EGM2008 in the appropriate spectral bands. The investigation also contain the assessment of the coherence and the correlation between the Earth gravity field parameters (free-air gravity anomalies and geoid undulations), derived from the validated geopotential models and terrestrial data (GPS/leveling, terrestrial gravity observations, DTM etc.), as well as the WGM2012 products. In the conclusion, with the numerical results, the performance of the assessed models are clarified in Turkish territory and the potential of the Wavelet decomposition in the improvement of the geopotential models is verified.

GOCE gravity gradient data for lithospheric modeling - From well surveyed to frontier areas

NASA Astrophysics Data System (ADS)

Bouman, J.; Ebbing, J.; Gradmann, S.; Fuchs, M.; Fattah, R. Abdul; Meekes, S.; Schmidt, M.; Lieb, V.; Haagmans, R.

2012-04-01

We explore how GOCE gravity gradient data can improve modeling of the Earth's lithosphere and thereby contribute to a better understanding of the Earth's dynamic processes. The idea is to invert satellite gravity gradients and terrestrial gravity data in the well explored and understood North-East Atlantic Margin and to compare the results of this inversion, providing improved information about the lithosphere and upper mantle, with results obtained by means of models based upon other sources like seismics and magnetic field information. Transfer of the obtained knowledge to the less explored Rub' al Khali desert is foreseen. We present a case study for the North-East Atlantic margin, where we analyze the use of satellite gravity gradients by comparison with a well-constrained 3D density model that provides a detailed picture from the upper mantle to the top basement (base of sediments). The latter horizon is well resolved from gravity and especially magnetic data, whereas sedimentary layers are mainly constrained from seismic studies, but do in general not show a prominent effect in the gravity and magnetic field. We analyze how gravity gradients can increase confidence in the modeled structures by calculating a sensitivity matrix for the existing 3D model. This sensitivity matrix describes the relation between calculated gravity gradient data and geological structures with respect to their depth, extent and relative density contrast. As the sensitivity of the modeled bodies varies for different tensor components, we can use this matrix for a weighted inversion of gradient data to optimize the model. This sensitivity analysis will be used as input to study the Rub' al Khali desert in Saudi Arabia. In terms of modeling and data availability this is a frontier area. Here gravity gradient data will be used to better identify the extent of anomalous structures within the basin, with the goal to improve the modeling for hydrocarbon exploration purposes.

Improvement of Latvian Geoid Model Using GNSS/Levelling, GOCE Data and Vertical Deflection Measurements

NASA Astrophysics Data System (ADS)

Janpaule, Inese; Haritonova, Diana; Balodis, Janis; Zarins, Ansis; Silabriedis, Gunars; Kaminskis, Janis

2015-03-01

Development of a digital zenith telescope prototype, improved zenith camera construction and analysis of experimental vertical deflection measurements for the improvement of the Latvian geoid model has been performed at the Institute of Geodesy and Geoinformatics (GGI), University of Latvia. GOCE satellite data was used to compute geoid model for the Riga region, and European gravimetric geoid model EGG97 and 102 data points of GNSS/levelling were used as input data in the calculations of Latvian geoid model.

Daily variation of diurnal thermal tides from CHAMP and GOCE accelerometer measurements

NASA Astrophysics Data System (ADS)

Gasperini, Federico; Doornbos, Eelco; Forbes, Jeffrey M.; Bruinsma, Sean; Haeusler, Kathrin; Hagan, Maura

Daily migrating and non-migrating diurnal tides in exospheric temperature derived from simultaneous accelerometer measurements on CHAMP (near 300 km) and GOCE (near 260 km) are studied for the intervals November-December 2009 and March-April 2010. Neutral densities are converted to exospheric temperatures using the NRLMSISe00 empirical model and by iterating on a convenient parameter (e.g. F10.7 solar flux). This methodology is validated using NCAR TIME-GCM simulations for this period as a mock data set, and results are compared to an approach where differences between ascending and descending orbital measurements are used to estimate diurnal tides for CHAMP and GOCE separately. The tidal components analyzed are the westward-propagating components with zonal wave numbers s=1 and s=2 (DW1 and DW2) and the eastward-propagating components with s=-2 and s=-3 (DE2 and DE3). Spectral analyses are used to reveal potential planetary wave modulations of the daily tidal amplitudes.

Satellite altimetry and GOCE contribution to the pre-definition of the Kingdom of Saudi Arabia (KSA) Vertical Network

NASA Astrophysics Data System (ADS)

Vergos, Georgios S.; Grebenitcharsky, Rossen S.; Natsiopoulos, Dimitrios A.; Al-Kherayef, Othman; Al-Muslmani, Bandar

2017-04-01

The availability of a unified and well-established national vertical system and frame is of outmost importance in support of everyday geodetic, surveying and engineering applications. Vertical reference system (VRS) modernization and unification has gained increased importance especially during the last years due to the advent of gravity-field dedicated missions and GOCE in particular, since it is the first time that an unprecedented in accuracy dataset of gravity field functionals has become available at a global scale. The Kingdom of Saudi Arabia VRS is outdated and exhibits significant tilts and biases, so that during the last couple of years an extensive effort has been put forth in order to: re-measure by traditional levelling the entire network, establish new benchmarks (BMs), perform high-quality absolute and relative gravity observations and construct new tide-gauge (TG) stations in both the Arab and Red Seas. The Current work focuses on the combined analysis of the existing, recently collected, terrestrial observations with satellite altimetry data and the latest GOCE-based Earth Geopotential Models (EGMs) in order to provide a pre-definition of the KSA VRS. To that respect, a 30-year satellite altimetry time-series is constructed for each TG station in order to derive both the Mean Sea Level (MSL) as well as the sea level trends. This information is analyzed, through Wavelet (WL) Multi-resolution Analysis (MRA), with the TG sea level records in order to determine annual, semi-annual and secular trends of the Red and Arab Sea variations. Finally, the so-derived trends and MSL are combined with local gravity observations at the TG BMs, levelling offsets between the TGs and the network BMs, levelling observations between the network BMs themselves and GOCE-based EGM-derived geoid heights and potential values. The validation of GOCE contribution and of the satellite altimetry derived MSL and trends is based on a simultaneous adjustment of the entire KSA vertical network, keeping fixed various TG stations and investigating the distortions introduced in the adjusted BM orthometric heights. Finally, a pre-definition of the KSA VRS is detailed as vertical offsets and potential differences δWo relative to the recently adopted conventional zero-level geopotential value by IAG. Conclusions regarding the contribution of satellite altimetry and GOCE are drown along with the necessary information for the definition of the KSA vertical datum and its connection to an International Height References System (IHRS).

The BRAT and GUT Couple: Broadview Radar Altimetry and GOCE User Toolboxes

NASA Astrophysics Data System (ADS)

Benveniste, J.; Restano, M.; Ambrózio, A.

2017-12-01

The Broadview Radar Altimetry Toolbox (BRAT) is a collection of tools designed to facilitate the processing of radar altimetry data from previous and current altimetry missions, including Sentinel-3A L1 and L2 products. A tutorial is included providing plenty of use cases. BRAT's next release (4.2.0) is planned for October 2017. Based on the community feedback, the front-end has been further improved and simplified whereas the capability to use BRAT in conjunction with MATLAB/IDL or C/C++/Python/Fortran, allowing users to obtain desired data bypassing the data-formatting hassle, remains unchanged. Several kinds of computations can be done within BRAT involving the combination of data fields, that can be saved for future uses, either by using embedded formulas including those from oceanographic altimetry, or by implementing ad-hoc Python modules created by users to meet their needs. BRAT can also be used to quickly visualise data, or to translate data into other formats, e.g. from NetCDF to raster images. The GOCE User Toolbox (GUT) is a compilation of tools for the use and the analysis of GOCE gravity field models. It facilitates using, viewing and post-processing GOCE L2 data and allows gravity field data, in conjunction and consistently with any other auxiliary data set, to be pre-processed by beginners in gravity field processing, for oceanographic and hydrologic as well as for solid earth applications at both regional and global scales. Hence, GUT facilitates the extensive use of data acquired during GRACE and GOCE missions. In the current 3.1 version, GUT has been outfitted with a graphical user interface allowing users to visually program data processing workflows. Further enhancements aiming at facilitating the use of gradients, the anisotropic diffusive filtering, and the computation of Bouguer and isostatic gravity anomalies have been introduced. Packaged with GUT is also GUT's Variance-Covariance Matrix tool (VCM). BRAT and GUT toolboxes can be freely downloaded, along with ancillary material, at https://earth.esa.int/brat and https://earth.esa.int/gut.

Improvement of the GPS/A system for extensive observation along subduction zones around Japan

NASA Astrophysics Data System (ADS)

Fujimoto, H.; Kido, M.; Tadokoro, K.; Sato, M.; Ishikawa, T.; Asada, A.; Mochizuki, M.

2011-12-01

Combined high-resolution gravity field models serve as a mandatory basis to describe static and dynamic processes in system Earth. Ocean dynamics can be modeled referring to a high-accurate geoid as reference surface, solid earth processes are initiated by the gravity field. Also geodetic disciplines such as height system determination depend on high-precise gravity field information. To fulfill the various requirements concerning resolution and accuracy, any kind of gravity field information, that means satellite as well as terrestrial and altimetric gravity field observations have to be included in one combination process. A key role is here reserved for GOCE observations, which contribute with its optimal signal content in the long to medium wavelength part and enable a more accurate gravity field determination than ever before especially in areas, where no high-accurate terrestrial gravity field observations are available, such as South America, Asia or Africa. For our contribution we prepare a combined high-resolution gravity field model up to d/o 720 based on full normal equation including recent GOCE, GRACE and terrestrial / altimetric data. For all data sets, normal equations are set up separately, relative weighted to each other in the combination step and solved. This procedure is computationally challenging and can only be performed using super computers. We put special emphasis on the combination process, for which we modified especially our procedure to include GOCE data optimally in the combination. Furthermore we modified our terrestrial/altimetric data sets, what should result in an improved outcome. With our model, in which we included the newest GOCE TIM4 gradiometry results, we can show how GOCE contributes to a combined gravity field solution especially in areas of poor terrestrial data coverage. The model is validated by independent GPS leveling data in selected regions as well as computation of the mean dynamic topography over the oceans. Further, we analyze the statistical error estimates derived from full covariance propagation and compare them with the absolute validation with independent data sets.

Spherical and ellipsoidal arrangement of the topography and its impact on gravity gradients in the GOCE mission

NASA Astrophysics Data System (ADS)

Grombein, Thomas; Seitz, Kurt; Heck, Bernhard

2010-05-01

The basic observables of the recently launched satellite gravity gradiometry mission GOCE are the second derivatives of the earth gravitational potential (components of the full Marussi tensor). These gravity gradients are highly sensitive to mass anomalies and mass transports in the earth system. The high- and mid-frequency components of the gradients are mainly affected by the topographic and isostatic masses whereby the downward continuation of the gradients is a rather difficult task. In order to stabilize this process the gradients have to be smoothed by applying topographic and isostatic reductions. In the space domain the modelling of topographic effects is based on the evaluation of functionals of the Newton integral. In the case of GOCE the second-order derivatives are required. Practical numerical computations rely on a discretisation of the earth's topography and a subdivision into different mass elements. Considering geographical gridlines tesseroids (spherical prisms) are well suited for the modelling of the topographic masses. Since the respective volume integrals cannot be solved in an elementary way in the case of tesseroids numerical approaches such as Taylor series expansion, Gauss-Legendre cubature or a point-mass approximation have to be applied. In this paper the topography is represented by the global Digital Terrain Model DTM2006.0 which was also used for the compilation of the Earth Gravitation Model EGM2008. In addition, each grid element of the DTM is classified as land, see or ice providing further information on the density within the evaluation of topographic effects. The computation points are located on a GOCE-like circular orbit. The mass elements are arranged on a spherical earth of constant radius and, in a more realistic composition, on the surface of an ellipsoid of revolution. The results of the modelling of each version are presented and compared to each other with regard to computation time and accuracy. Acknowledgements: This research has been financially supported by the German Federal Ministry of Education and Research (BMBF) within the REAL-GOCE project of the GEOTECHNOLOGIEN Programme.

GOCE: The first seismometer in orbit around the Earth

NASA Astrophysics Data System (ADS)

Garcia, Raphael F.; Bruinsma, Sean; Lognonné, Philippe; Doornbos, Eelco; Cachoux, Florian

2013-03-01

The first in situ sounding of a post-seismic infrasound wavefront is presented, using data from the GOCE mission. The atmospheric infrasounds following the great Tohoku earthquake (on 11 March 2011) induce variations of air density and vertical acceleration of the GOCE platform. These signals are detected at two positions along the GOCE orbit corresponding to a crossing and a doubling of the infrasonic wavefront created by seismic surface waves. Perturbations up to 11% of air density and 1.35 × 10 - 7 m/s2 of vertical acceleration are observed and modeled with two different solid-atmosphere coupling codes. These perturbations are a due to acoustic waves creating vertical velocities up to 130 m/s. Amplitudes and arrival times of these perturbations are reproduced respectively within a factor 2, and within a 60 s time window. Waveforms present a good agreement with observed data. The vertical acceleration to air density perturbation ratio is higher for these acoustic waves than for gravity waves. Combining these two pieces of information offers a new way to distinguish between these two wave types. This new type of data is a benchmark for the models of solid-atmosphere coupling. Amplitude and frequency content constrain the infrasound attenuation related to atmosphere viscosity and thermal conductivity. Observed time shifts between data and synthetics are ascribed to lateral variations of the seismic and atmospheric sound velocities and to the influence of atmospheric winds. These effects should be included in future modeling. This validation of our modeling tools allows to specify more precisely future observation projects.

Simultaneous Observations of TADs in GOCE, CHAMP and GRACE Density Data Compared with CTIPe

NASA Astrophysics Data System (ADS)

Bruinsma, S. L.; Fedrizzi, M.

2012-12-01

The accelerometers on the CHAMP and GRACE satellites have made it possible to accumulate near-continuous records of thermosphere density between about 300 and 490 km since May 2001, and July 2002, respectively. Since November 2009, a third gravity field satellite mission, ESA's GOCE, is in a very low and near heliosynchronous dawn-dusk orbit at about 270 km. The spacecraft is actively maintained at that constant altitude using an ion propulsion engine that compensates the aerodynamic drag in the flight direction. The thrust level, combined with accelerometer and satellite attitude data, is used to compute atmospheric densities and cross-track winds. The response of the thermosphere to geomagnetic disturbances, i.e., space weather, has been extensively studied using the exceptional datasets of CHAMP and GRACE. Thanks to GOCE we now have a third excellent data set for these studies. In this presentation we will show the observed density and its variability for the geomagnetic storm of 5 April 2010, and compare it with predictions along the orbits obtained from a self-consistent physics-based coupled model of the thermosphere, ionosphere, plasmasphere and electrodynamics (CTIPe). For this storm, the CHAMP and GOCE orbit planes were perpendicular (12/24 Local Solar Time, and 6/18 LST, respectively) and the altitude difference was only approximately 30 km. The GRACE densities are at a much higher altitude of about 475 km. Wave-like features are revealed or enhanced after filtering of the densities and calculation of relative density variations. Traveling Atmospheric Disturbances are observed in the data, and the model's fidelity in reproducing the waves is evaluated.

Remote Sensing the Thermosphere's State Using Emissions From Carbon Dioxide and Nitric Oxide

NASA Astrophysics Data System (ADS)

Weimer, D. R.; Mlynczak, M. G.; Doornbos, E.

2017-12-01

Measurements of emissions from nitric oxide and carbon dioxide in the thermosphere have strong correlations with properties that are very useful to the determination of thermospheric densities. We have compared emissions measured with the Sounding of the Atmosphere using Broadband Emission Radiometry (SABER) instrument on the Thermosphere Ionosphere Mesosphere Energetics and Dynamics (TIMED) satellite with neutral density measurements from the Challenging Mini-satellite Payload (CHAMP), the Gravity Recovery and Climate Experiment (GRACE), the Ocean Circulation Explorer (GOCE), and the three Swarm satellites, spanning a time period of over 15 years. It has been found that nitric oxide emissions match changes in the exospheric temperatures that have been derived from the densities through use of the Naval Reasearch Laboratory Mass Spectrometer, Incoherent Scatter Radar Extended Model (NRLMSISE-00) thermosphere model. Similarly, our results indicate that the carbon dioxide emissions have annual and semiannual oscillations that correlate with changes in the amount of oxygen in the thermosphere, also determined by use of the NRLMSISE-00 model. These annual and semi-annual variations are found to have irregular amplitudes and phases, which make them very difficult to accurately predict. Prediction of exospheric temperatures through the use of geomagnetic indices also tends to be inexact. Therefore, it would be possible and very useful to use measurements of the thermosphere's infrared emissions for real-time tracking of the thermosphere's state, so that more accurate calculations of the density may be obtained.

News and Views: Space technology in the oil industry; OU to play role in next stage of Mars exploration; Viking revisited; Wish you were here? GOCE gets going again

NASA Astrophysics Data System (ADS)

2010-10-01

The troubles flowing from BP's Macondo oil well in Gulf of Mexico have focused attention on the technological demands of safe deep-water drilling. European Space Agency research presented in a Space and Energy Seminar in August offers spin-off technologies that could support oil exploration and production in extreme environments, from corrosion control to better robotics. NASA and the European Space Agency have embarked on a joint programme to study the chemical composition of the atmosphere of Mars from 2016. They have just announced the providers of five scientific instruments for the first mission, including two consortia in which the Open University has a major role.

GOCE User Toolbox and Tutorial

NASA Astrophysics Data System (ADS)

Knudsen, P.; Benveniste, J.

2011-07-01

The GOCE User Toolbox GUT is a compilation of tools for the utilisation and analysis of GOCE Level 2 products. GUT support applications in Geodesy, Oceanography and Solid Earth Physics. The GUT Tutorial provides information and guidance in how to use the toolbox for a variety of applications. GUT consists of a series of advanced computer routines that carry out the required computations. It may be used on Windows PCs, UNIX/Linux Workstations, and Mac. The toolbox is supported by The GUT Algorithm Description and User Guide and The GUT Install Guide. A set of a-priori data and models are made available as well. GUT has been developed in a collaboration within the GUT Core Group. The GUT Core Group: S. Dinardo, D. Serpe, B.M. Lucas, R. Floberghagen, A. Horvath (ESA), O. Andersen, M. Herceg (DTU), M.-H. Rio, S. Mulet, G. Larnicol (CLS), J. Johannessen, L.Bertino (NERSC), H. Snaith, P. Challenor (NOC), K. Haines, D. Bretherton (NCEO), C. Hughes (POL), R.J. Bingham (NU), G. Balmino, S. Niemeijer, I. Price, L. Cornejo (S&T), M. Diament, I Panet (IPGP), C.C. Tscherning (KU), D. Stammer, F. Siegismund (UH), T. Gruber (TUM),

Rigorous covariance propagation of geoid errors to geodetic MDT estimates

NASA Astrophysics Data System (ADS)

Pail, R.; Albertella, A.; Fecher, T.; Savcenko, R.

2012-04-01

The mean dynamic topography (MDT) is defined as the difference between the mean sea surface (MSS) derived from satellite altimetry, averaged over several years, and the static geoid. Assuming geostrophic conditions, from the MDT the ocean surface velocities as important component of global ocean circulation can be derived from it. Due to the availability of GOCE gravity field models, for the very first time MDT can now be derived solely from satellite observations (altimetry and gravity) down to spatial length-scales of 100 km and even below. Global gravity field models, parameterized in terms of spherical harmonic coefficients, are complemented by the full variance-covariance matrix (VCM). Therefore, for the geoid component a realistic statistical error estimate is available, while the error description of the altimetric component is still an open issue and is, if at all, attacked empirically. In this study we make the attempt to perform, based on the full gravity VCM, rigorous error propagation to derived geostrophic surface velocities, thus also considering all correlations. For the definition of the static geoid we use the third release of the time-wise GOCE model, as well as the satellite-only combination model GOCO03S. In detail, we will investigate the velocity errors resulting from the geoid component in dependence of the harmonic degree, and the impact of using/no using covariances on the MDT errors and its correlations. When deriving an MDT, it is spectrally filtered to a certain maximum degree, which is usually driven by the signal content of the geoid model, by applying isotropic or non-isotropic filters. Since this filtering is acting also on the geoid component, the consistent integration of this filter process into the covariance propagation shall be performed, and its impact shall be quantified. The study will be performed for MDT estimates in specific test areas of particular oceanographic interest.

Spectral characteristics of the Hellenic vertical network - Validation over Central and Northern Greece using GOCE/GRACE global geopotential models

NASA Astrophysics Data System (ADS)

Andritsanos, Vassilios D.; Vergos, George S.; Grigoriadis, Vassilios N.; Pagounis, Vassilios; Tziavos, Ilias N.

2014-05-01

The Elevation project, funded by the action "Archimedes III - Funding of research groups in T.E.I.", co-financed by the E.U. (European Social Fund) and national funds under the Operational Program "Education and Lifelong Learning 2007-2013" aims mainly to the validation of the Hellenic vertical datum. This validation is carried out over two areas under study, one in Central and another in Northern Greece. During the first stage of the validation process, satellite-only as well as combined satellite-terrestrial models of the Earth's geopotential are used. GOCE and GRACE satellite information is compared against recently measured GPS/Levelling observations at specific benchmarks of the vertical network in Attiki (Central Greece) and Thessaloniki (Northern Greece). A spectral enhancement approach is followed where, given the GOCE/GRACE GGM truncation degree, EGM2008 is used to fill-in the medium and high-frequency content along with RTM effects for the high and ultra high part. The second stage is based on the localization of possible blunders of the vertical network using the spectral information derived previously. The undoubted accuracy of the contemporary global models at the low frequency band leads to some initial conclusions about the consistency of the Hellenic vertical datum.

GOCE Re-Entry Predictions for the Italian Civil Protection Authorities

NASA Astrophysics Data System (ADS)

Pardini, Carmen; Anselmo, Luciano

2015-03-01

The uncommon nature of the GOCE reentry campaign, sharing an uncontrolled orbital decay with a finely controlled attitude along the atmospheric drag direction, made the reentry predictions for this satellite an interesting case study, especially because nobody was able to say a priori if and when the attitude control would have failed, leading to an unrestrained tumbling and a sudden variation of the orbital decay rate. As in previous cases, ISTI/CNR was in charge of reentry predictions for the Italian civil protection authorities, monitoring also the satellite decay in the frame of an international reentry campaign promoted by the Inter-Agency Space Debris Coordination Committee (IADC). Due to the peculiar nature of the GOCE reentry, the definition of reliable uncertainty windows was not easy, especially considering the critical use of this information for civil protection evaluations. However, after an initial period of test and analysis, reasonable and conservative criteria were elaborated and applied, with good and consistent results through the end of the reentry campaign. In the last three days of flight, reentries were simulated over Italy to obtain quite accurate ground tracks, debris swaths and air space crossing time windows associated with the critical passes over the national territory still included in the global uncertainty windows.

Experiences with GOCE models in SONMICAT-BCN calibration site.

NASA Astrophysics Data System (ADS)

Martinez-Benjamin, J. J.; Termens, A.; Pros, F.

2016-12-01

SONMICAT - the integrated sea level observation system of Catalonia - aims at providing high-quality continous measurements of sea- and land levels at the Catalan coast from tide gauges and from modern geodetic techniques for studies on long-term sea level trends, but also the calibration of satellite altimeters, for instance. This synergy is indeed the only way to get a clear and unambigous picture of what is actually going on at the coast of Catalonia. Actually, there is a gap of sea level data in the coastal area of Catalonia, although several groups have started to do some work. SONMICAT will fill it and, as a goal, will be a regional implementation and densification of the GGOS . In the framework of SONMICAT project, the sea level infrastructure has been improved by providing the harbour of Barcelona with 3 tide gauges and a GPS station nearby. Furthermore, an airborne LiDAR campaign was carried out with two strips along two ICESat target tracks. The work focuses on the comparison between the GOCE gravity field solutions with existing local an regional gravity field models over the area of Barcelona harbour. The study will estimate how GOCE works on SONMICAT-BCN calibration site in order to prepare future geomatics issues .

Torus Approach in Gravity Field Determination from Simulated GOCE Gravity Gradients

NASA Astrophysics Data System (ADS)

Liu, Huanling; Wen, Hanjiang; Xu, Xinyu; Zhu, Guangbin

2016-08-01

In Torus approach, observations are projected to the nominal orbits with constant radius and inclination, lumped coefficients provides a linear relationship between observations and spherical harmonic coefficients. Based on the relationship, two-dimensional FFT and block-diagonal least-squares adjustment are used to recover Earth's gravity field model. The Earth's gravity field model complete to degree and order 200 is recovered using simulated satellite gravity gradients on a torus grid, and the degree median error is smaller than 10-18, which shows the effectiveness of Torus approach. EGM2008 is employed as a reference model and the gravity field model is resolved using the simulated observations without noise given on GOCE orbits of 61 days. The error from reduction and interpolation can be mitigated by iterations. Due to polar gap, the precision of low-order coefficients is lower. Without considering these coefficients the maximum geoid degree error and cumulative error are 0.022mm and 0.099mm, respectively. The Earth's gravity field model is also recovered from simulated observations with white noise 5mE/Hz1/2, which is compared to that from direct method. In conclusion, it is demonstrated that Torus approach is a valid method for processing massive amount of GOCE gravity gradients.

The Use of GOCE/GRACE Information in the Latest NGS xGeoid15 Model for the USA

NASA Astrophysics Data System (ADS)

Holmes, S. A.; Li, X.; Youngman, M.

2015-12-01

The U.S. National Geodetic Survey [NGS], through its Gravity for the Redefinition of the American Vertical Datum [GRAV-D] program, is flying airborne gravity surveys over the USA and its territories. By 2022, NGS intends that all orthometric heights in the USA will be determined in the field using a reliable national gravimetric geoid model to transform from geodetic heights obtained from GPS. Towards this end, all available airborne data has been incorporated into a new NGS experimental geoid model - xGEOID15. The xGEOID15 model is the second in a series of annual experimental geoid models that incorporates NGS GRAV-D airborne data. This series provides a useful benchmark for assessing and improving current techniques, to ultimately compute a geoid model that can support a national physical height system by 2022. Here, we focus on the combination of the latest GOCE/GRACE models with the terrestrial gravimetry (land/airborne) that was applied for xGeoid15. Comparisons against existing combination gravitational solutions, such as EGM2008 and EIGEN6C4, as well as recent geoid models, such as xGeoid14 and CGG2013, are interesting for what they reveal about the respective use of the GOCE/GRACE satgrav information.

Geological Implications From Complete Gondwana GOCE- Products Reconstructions and Link to Lithospheric Roots

NASA Astrophysics Data System (ADS)

Braitenberg, Carla; Mariani, Patrizia

2015-03-01

The GOCE gravity field is globally homogeneous at the resolution of about 80km or better allowing for the first time to analyze tectonic structures at continental scale. Geologic correlation studies propose to continue the tectonic lineaments across continents to the pre-breakup position. Tectonic events that induce density changes, as metamorphic events and magmatic events, should then show up in the gravity field. Applying geodynamic plate reconstructions to the GOCE gravity field places today’s observed field at the pre-breakup position. The same reconstruction can be applied to the seismic velocity models, to allow a joint gravity-velocity analysis. The geophysical fields allow to control the likeliness of the hypothesized continuation of lineations based on sparse surface outcrops. Total absence of a signal, makes the cross-continental continuation of the lineament improbable, as continental-wide lineaments are controlled by rheologic and compositional differences of lithospheric mantle. It is found that the deep lithospheric roots as those found below cratons control the position of the positive gravity values. The explanation is that the deep lithospheric roots focus asthenospheric upwelling outboard of the root protecting the overlying craton from magmatic intrusions. The study is carried out over the African and South American continents.

Sediment basin modeling through GOCE gradients controlled by thermo-isostatic constraints

NASA Astrophysics Data System (ADS)

Pivetta, Tommaso; Braitenberg, Carla

2015-04-01

Exploration of geodynamic and tectonic structures through gravity methods has experienced an increased interest in the recent years thank's to the possibilities offered by satellite gravimetry (e.g. GOCE). The main problem with potential field methods is the non-uniqueness of the underground density distributions that satisfy the observed gravity field. In terrestrial areas with scarce geological and geophysical information, valid constraints to the density model could be obtained from the application of geodynamic models. In this contribution we present the study of the gravity signals associated to the thermo-isostatic McKenzie-model (McKenzie, 1978) that predicts the development of sedimentary basins from the stretching of lithosphere. This model seems to be particularly intriguing for gravity studies as we could obtain estimates of densities and thicknesses of crust and mantle before and after a rifting event and gain important information about the time evolution of the sedimentary basin. The McKenzie-model distinguishes the rifting process into two distinct phases: a syn-rift phase that occurs instantly and is responsible of the basin formation, the thinning of lithosphere and the upwelling of hot asthenosphere. Then a second phase (post-rift), that is time dependent, and predicts further subsidence caused by the cooling of mantle and asthenosphere and subsequently increase in rock density. From the application of the McKenzie-model we have derived density underground distributions for two scenarios: the first scenario involves the lithosphere density distribution immediately after the stretching event; the second refers to the density model when thermal equilibrium between stretched and unstretched lithospheres is achieved. Calculations of gravity anomalies and gravity gradient anomalies are performed at 5km height and at the GOCE mean orbit quota (250km). We have found different gravity signals for syn-rift (gravimetric maximum) and post-rift (gravimetric minimum) scenarios and that satellite measurements are sufficiently precise to discriminate between them. The McKenzie-model is then applied to a real basin in Africa, the Benue Trough, which is an aborted rift that seems to be particularly adapt to be studied with satellite gravity techniques. McKenzie D., 1978, Some remarks on the development of sedimentary basins, Earth and Planetary Science Letters, 40, 25-32

A combined mean dynamic topography model - DTU17cMDT

NASA Astrophysics Data System (ADS)

Knudsen, P.; Andersen, O. B.; Nielsen, K.; Maximenko, N. A.

2017-12-01

Within the ESA supported Optimal Geoid for Modelling Ocean Circulation (OGMOC) project a new geoid model have been derived. It is based on the GOCO05C setup though the newer DTU15GRA altimetric surface gravity has been used in the combination. Subsequently the model has been augmented using the EIGEN-6C4 coefficients to d/o 2160. Compared to the DTU13MSS, the DTU15MSS has been derived by including re-tracked CRYOSAT-2 altimetry also, hence, increasing its resolution. Also, some issues in the Polar regions have been solved. The new DTU17MDT has been derived using this new geoid model and the DTU15MSS mean sea surface. Compared to other geoid models the new OGMOC geoid model has been optimized to avoid striations and orange skin like features. The filtering was re-evaluated by adjusting the quasi-gaussian filter width to optimize the fit to drifter velocities. The results show that the new MDT improves the resolution of the details of the ocean circulation. Subsequently, the drifter velocities were integrated to enhance the resolution of the MDT. As a contribution to the ESA supported GOCE++ project DYCOT a special concern was devoted to the coastal areas to optimize the extrapolation towards the coast and to integrate mean sea levels at tide gauges into that process. The presentation will focus on the coastal zone when assessing the methodology, the data and the final model DTU17cMDT.

GOCE-based height system unification between Greece and Turkey. First considerations over marine and land areas

NASA Astrophysics Data System (ADS)

Vergos, Georgios S.; Erol, Bihter; Natsiopoulos, Dimitrios A.; Grigoriadis, Vassilios N.; Serkan Işık, Mustafa; Tziavos, Ilias N.

2016-04-01

The unification of local vertical Datums (LVDs) at a country-wide scale has gained significant attention lately, due to the availability of GOCE-based Global Geopotential Models (GGMs). The latter, offer unprecedented geoid height accuracies at the 1-1.5 cm level for spherical harmonic expansions to d/o 225-230. Within a single country, several LVDs may be used, especially in the event of islandic nations, therefore the unification of all of them to a single nation-wide LVD is of utmost importance. The same holds for neighboring countries, where the unification of their vertical datums is necessary as a tool of engineering, cross-border collaboration and environmental and risk management projects. The aforementioned set the main scope of the work carried out in the frame of the present study, which referred to the use of GOCE and GOCE/GRACE GGMs in order to unify the LVDs of Greece and Turkey. It is well-known that the two countries share common borders and are a path for large-scale engineering projects in the energy sector. Therefore, the availability of a common reference for orthometric heights in both countries and/or the determination of the relative offset of their individual zero-level geopotential value poses an emerging issue. The determination of the geopotential value Wo(LVD) for the Greek and Turkish LVDs was first carried out separately for each region performing as well different estimates for the marine area of the Aegean Sea and the terrestrial border-region along eastern Thrace. From that, possible biases of the Hellenic and Turkish LVDs themselves have been drawn and analyzed to determine spatial correlations. Then, the relative offset between the two LVDs was determined employing GPS/Levelling data for both areas and the latest GO-DIR-R5, GO-TIM-R5 and GOCO05s models as well as EGM2008. The estimation of the mean offset was used to provide as well a direct link between the Greek and Turkish LVDs with the IAG conventional value recently proposed as a Wo for a global WHS.

Modelling airborne gravity data by means of adapted Space-Wise approach

NASA Astrophysics Data System (ADS)

Sampietro, Daniele; Capponi, Martina; Hamdi Mansi, Ahmed; Gatti, Andrea

2017-04-01

Regional gravity field modelling by means of remove - restore procedure is nowadays widely applied to predict grids of gravity anomalies (Bouguer, free-air, isostatic, etc.) in gravimetric geoid determination as well as in exploration geophysics. Considering this last application, due to the required accuracy and resolution, airborne gravity observations are generally adopted. However due to the relatively high acquisition velocity, presence of atmospheric turbulence, aircraft vibration, instrumental drift, etc. airborne data are contaminated by a very high observation error. For this reason, a proper procedure to filter the raw observations both in the low and high frequency should be applied to recover valuable information. In this work, a procedure to predict a grid or a set of filtered along track gravity anomalies, by merging GGM and airborne dataset, is presented. The proposed algorithm, like the Space-Wise approach developed by Politecnico di Milano in the framework of GOCE data analysis, is based on a combination of along track Wiener filter and Least Squares Collocation adjustment and properly considers the different altitudes of the gravity observations. Among the main differences with respect to the satellite application of the Space-Wise approach there is the fact that, while in processing GOCE data the stochastic characteristics of the observation error can be considered a-priori well known, in airborne gravimetry, due to the complex environment in which the observations are acquired, these characteristics are unknown and should be retrieved from the dataset itself. Some innovative theoretical aspects focusing in particular on the theoretical covariance modelling are presented too. In the end, the goodness of the procedure is evaluated by means of a test on real data recovering the gravitational signal with a predicted accuracy of about 0.25 mGal.

Suggestions for Improvement of User Access to GOCE L2 Data

NASA Astrophysics Data System (ADS)

Tscherning, C. C.

2011-07-01

ESA's has required that most GOCE L2 products are delivered in XML format. This creates difficulties for the users because a Parser written in Perl is needed to convert the files to files without XML tags. However several products, such as the coefficients of spherical harmonic coefficients are made available on standard form through the International Center for Global Gravity Field Models. The variance-covariance information for the gravity field models is only available without XML tags. It is suggested that all XML products are made available in the Virtual Data Archive as files without tags. This will besides making the data directly usable by a FORTRAN program also reduce the size (storage requirements) of the product to about 30 %. A further reduction of used storage should be made by tuning the number of digits for the individual quantities in the products, so that it corresponds to the actual number of significant digits.

New geoid of Greenland - a case study of terrain and ice effects, GOCE and local sea level data

NASA Astrophysics Data System (ADS)

Forsberg, R.; Jensen, T.

2014-12-01

Making an accurate geoid model of Greenland has always been a challenge due to the ice sheet and glaciers, and the rough topography and deep fjords in the ice free parts. Terrestrial gravity coverage has for the same reasons been relatively sparse, with an older NRL high-level airborne survey of the interior being the only gravity field data over the interior, and terrain and ice thickness models being insufficient both in terms of resolution and accuracy. This data situation has in the later years changed substantially, first of all due to GOCE, but also due to new DTU-Space and NASA IceBridge airborne gravity, ice thickness data from IceBridge and European airborne measurements, and new terrain models from ASTER, SPOT-5 and digital photogrammetry. In the paper we use all available data to make a new geoid of Greenland and surrounding ocean regions, using remove-restore techniques for ice and topography, spherical FFT techniques and downward continuation by least squares collocation. The impact of GOCE and the new terrestrial data yielded a much improved geoid. Due to the lack of of levelling data connecting scattered towns, the new geoid is validated by local sea level and dynamic ocean topography data, and specially collected GPS-tide gauge profile data along fjords. The comparisons show significant improvements over EGM08 and older geoid models, and also highlight the problems of global sea level models, especially in sea ice covered regions, and the definition of a new consistent vertical datum of Greenland.

First Release of Gravimetric Geoid Model over Saudi Arabia Based on Terrestrial Gravity and GOCE Satellite Data: KSAG01

NASA Astrophysics Data System (ADS)

Alothman, A. O.; Elsaka, B.

2015-12-01

A new gravimetric quasi-geoid, known as KSAG0, has been developed recently by Remove-Compute-Restore techniques (RCR), provided by the GRAVSOFT software, using gravimetric free air anomalies. The terrestrial gravity data used in this computations are: 1145 gravity field anomalies observed by ARAMCO (Saudi Arabian Oil Company) and 2470 Gravity measurements from BGI (Bureau Gravimétrique International). The computations were carried out implementing the least squares collocation method through the RCR techniques. The KSAG01 is based on merging in addition to the terrestrial gravity observations, GOCE satellite model (Eigen-6C4) and global gravity model (EGM2008) have been utilized in the computations. The long, medium and short wavelength spectrum of the height anomalies were compensated from Eigen-6C4 and EGM2008 geoid models truncated up to Degree and order (d/o) up to 2190. KSAG01 geoid covers 100 per cent of the kingdom, with geoid heights range from - 37.513 m in the southeast to 23.183 m in the northwest of the country. The accuracy of the geoid is governed by the accuracy, distribution, and spacing of the observations. The standard deviation of the predicted geoid heights is 0.115 m, with maximum errors of about 0.612 m. The RMS of geoid noise ranges from 0.019 m to 0.04 m. Comparison of the predicted gravimetric geoid with EGM, GOCE, and GPS/Levelling geoids, reveals a considerable improvements of the quasi-geoid heights over Saudi Arabia.

First Release of Gravimetric Geoid Model over Saudi Arabia Based on Terrestrial Gravity and GOCE Satellite Data: KSAG01

NASA Astrophysics Data System (ADS)

Alothman, Abdulaziz; Elsaka, Basem

2016-04-01

A new gravimetric quasi-geoid, known as KSAG0, has been developed recently by Remove-Compute-Restore techniques (RCR), provided by the GRAVSOFT software, using gravimetric free air anomalies. The terrestrial gravity data used in this computations are: 1145 gravity field anomalies observed by ARAMCO (Saudi Arabian Oil Company) and 2470 Gravity measurements from BGI (Bureau Gravimétrique International). The computations were carried out implementing the least squares collocation method through the RCR techniques. The KSAG01 is based on merging in addition to the terrestrial gravity observations, GOCE satellite model (Eigen-6C4) and global gravity model (EGM2008) have been utilized in the computations. The long, medium and short wavelength spectrum of the height anomalies were compensated from Eigen-6C4 and EGM2008 geoid models truncated up to Degree and order (d/o) up to 2190. KSAG01 geoid covers 100 per cent of the kingdom, with geoid heights range from - 37.513 m in the southeast to 23.183 m in the northwest of the country. The accuracy of the geoid is governed by the accuracy, distribution, and spacing of the observations. The standard deviation of the predicted geoid heights is 0.115 m, with maximum errors of about 0.612 m. The RMS of geoid noise ranges from 0.019 m to 0.04 m. Comparison of the predicted gravimetric geoid with EGM, GOCE, and GPS/Levelling geoids, reveals a considerable improvements of the quasi-geoid heights over Saudi Arabia.

ESA airborne campaigns in support of Earth Explorers

NASA Astrophysics Data System (ADS)

Casal, Tania; Davidson, Malcolm; Schuettemeyer, Dirk; Perrera, Andrea; Bianchi, Remo

2013-04-01

In the framework of its Earth Observation Programmes the European Space Agency (ESA) carries out ground based and airborne campaigns to support geophysical algorithm development, calibration/validation, simulation of future spaceborne earth observation missions, and applications development related to land, oceans and atmosphere. ESA has been conducting airborne and ground measurements campaigns since 1981 by deploying a broad range of active and passive instrumentation in both the optical and microwave regions of the electromagnetic spectrum such as lidars, limb/nadir sounding interferometers/spectrometers, high-resolution spectral imagers, advanced synthetic aperture radars, altimeters and radiometers. These campaigns take place inside and outside Europe in collaboration with national research organisations in the ESA member states as well as with international organisations harmonising European campaign activities. ESA campaigns address all phases of a spaceborne missions, from the very beginning of the design phase during which exploratory or proof-of-concept campaigns are carried out to the post-launch exploitation phase for calibration and validation. We present four recent campaigns illustrating the objectives and implementation of such campaigns. Wavemill Proof Of Concept, an exploratory campaign to demonstrate feasibility of a future Earth Explorer (EE) mission, took place in October 2011 in the Liverpool Bay area in the UK. The main objectives, successfully achieved, were to test Astrium UKs new airborne X-band SAR instrument capability to obtain high resolution ocean current and topology retrievals. Results showed that new airborne instrument is able to retrieve ocean currents to an accuracy of ± 10 cms-1. The IceSAR2012 campaign was set up to support of ESA's EE Candidate 7,BIOMASS. Its main objective was to document P-band radiometric signatures over ice-sheets, by upgrading ESA's airborne POLARIS P-band radar ice sounder with SAR capability. Campaign comprised three airborne campaigns in Greenland from April to June 2012 separated by roughly one month and preliminary results showed the instrument capability to detect ice motion. CryoVEx 2012 was a large collaborative effort to help ensure the accuracy of ESA's ice mission CryoSat. The aim of this large-scale Arctic campaign was to record sea-ice thickness and conditions of the ice exactly below the CryoSat-2 path. A range of sensors installed on different aircraft included simple cameras to get a visual record of the sea ice, laser scanners to clearly map the height of the ice, an ice-thickness sensor (EM-Bird), ESA's radar altimeter (ASIRAS) and NASA's snow and Ku-band radars, which mimic CryoSat's measurements but at a higher resolution. Preliminary results reveal the ability to detect centimetre differences between sea-ice and thin ice/water which in turn allow for the estimation of actual sea ice thickness. In support of two currently operating EE Missions: SMOS (Soil Moisture and Ocean Salinity) and GOCE (Gravity field and steady-state Ocean Circulation Explorer), DOMECair airborne campaign will take place in Antarctica, in the Dome C region during the middle of January 2013. The two main objectives are to quantify and document the spatial variability in the DOME C area, important to establish long-term cross-calibrated multi-mission L-band measurement time-series (SMOS) and fill in the gap in the high-quality gravity anomaly maps in Antarctica since airborne gravity measurements are sparse (GOCE). Key airborne instruments in the campaign are EMIRAD-2 L-band radiometer, designed and operated by DTU and a gravimeter from AWI. ESA campaigns have been fundamental and an essential part in the preparation of new Earth Observation missions, as well as in the independent validation of their measurements and quantification of error sources. For the different activities a rich variety of datasets has been recorded, are archived and users can access campaign data through the EOPI web portal [http://eopi.esa.int].

Geoid Determination Using GOCE-Based Models in Turkey

NASA Astrophysics Data System (ADS)

Serkan Işık, Mustafa; Erol, Bihter

2016-04-01

The maintenance of the vertical datum in tectonically active regions such as Turkey become more of an issue. The distortions in the vertical datum due to geodynamic phenomena necessitate the realization of geoid based vertical datum. The height modernization studies for transition to a "geoid based vertical datum definition" providing practical use of GNSS technologies to obtain orthometric heights in Turkey has accelerated rapidly in recent years and hence in the content of these efforts on-going projects contribute to improvement of quality and quantity of terrestrial gravity dataset as well as selection of the optimal computation algorithm to reach a precise geoid model in the territory. In this manner the assessment of the different methodologies with varying input parameters and referred models is obviously essential to in order to clarify the advantages of the algorithms in terms of providing an optimal combination of different data sets in regional geoid modeling. The performance of recently published GOCE-GRACE gravity field models show significant improvements in the medium frequency. This study investigates the contribution of the recently released Geopotential models with the contribution of GOCE and GRACE missions to the gravimetric geoid modeling specifically from Least squares modification of Stokes' (LSMS) formula point of view in Turkey territory. The algorithm developed by Royal Institute of Technology (KTH) that adopt the least squares modification of Stokes' kernel in order for providing an optimum combination of spherical harmonic expansion model and terrestrial gravity data and hence claims to optimize the drawbacks, may stem from the handicaps (such as low accuracy, sparse distribution etc.) of the terrestrial gravity data in the results. The additive corrective terms in order to account for downward continuation effect, atmospheric effect and ellipsoidal effect are proposed as the superiorities of this algorithm comparing to the conventional Remove-Restore method. The assessments of the geoid models are done at the homogeneously distributed thirty National Network points in Turkey. The positional accuracy of GNSS/Levelling points (belong the Turkey National Fundamental GNSS Network-TUTGA) are reported as ±1.0 cm in horizontal and ±1.5 cm in vertical components. The orthometric heights of these benchmarks are computed via adjustment of the Turkish National Vertical Control Network (TUDKA). All releases of direct (DIR), time-wise (TIM), space-wise (SPW) and Gravity Observation Combination (GOCO) models are evaluated using spectral enhancement method (SEM). DIR R5, TIM R5 and GOCO05S models, which show the best agreements with the GNSS/Levelling data, are included within the study and their performance are compared with EGM2008 model. In conclusion the GOCE gravity field models performs in the level very close to EGM2008 performance, when the same truncation degree of models are considered. The overall results reveal that the gravimetric geoid model which is computed using DIR R5 model provides the best performance having ±24.1 cm (without de-trending), though there is no significant improvement related with the contribution of GOCE gravity field models to the regional geoid determination based on LSMS approach in Turkey territory.

Characteristics of satellite accelerometer measurements of thermospheric neutral winds at high latitudes

NASA Astrophysics Data System (ADS)

Doornbos, E.; Ridley, A. J.; Cnossen, I.; Aruliah, A. L.; Foerster, M.

2015-12-01

Thermospheric neutral winds play an important part in the coupled thermosphere-ionosphere system at high latitudes. Neutral wind speeds have been derived from the CHAMP and GOCE satellites, which carried precise accelerometers in low Earth orbits. Due to the need to simultaneously determine thermosphere neutral density from the accelerometer in-track measurements, only information on the wind component in the cross-track direction, perpendicular to the flight direction can be derived. However, contrary to ground-based Fabry-Perot interferometer and scanning Doppler imager observations of the thermosphere wind, these satellite-based measurements provide equally distributed coverage over both hemispheres. The sampling of seasonal and local time variations depend on the precession rate of the satellite's orbital plane, with CHAMP covering about 28 cycles of 24-hour local solar time coverage, during its 10 year mission (2000-2010), while the near sun-synchronous orbit of GOCE resulted in a much more limited local time coverage ranging from 6:20 to 8:00 (am and pm), during a science mission duration of 4 years (2009-2013). For this study, the wind data from both CHAMP and GOCE have been analysed in terms of seasonal variations and geographic and geomagnetic local solar time and latitude coordinates, in order to make statistical comparisons for both the Northern and Southern polar areas. The wind data from both satellites were studied independently and in combination, in order to investigate how the strengths and weaknesses of the instruments and orbit parameters of these missions affect investigations of interhemispheric differences. Finally, the data have been compared with results from coupled ionosphere-thermosphere models and from ground-based FPI and SDI measurements.

Simulation-based evaluation of a cold atom interferometry gradiometer concept for gravity field recovery

NASA Astrophysics Data System (ADS)

Douch, Karim; Wu, Hu; Schubert, Christian; Müller, Jürgen; Pereira dos Santos, Franck

2018-03-01

The prospects of future satellite gravimetry missions to sustain a continuous and improved observation of the gravitational field have stimulated studies of new concepts of space inertial sensors with potentially improved precision and stability. This is in particular the case for cold-atom interferometry (CAI) gradiometry which is the object of this paper. The performance of a specific CAI gradiometer design is studied here in terms of quality of the recovered gravity field through a closed-loop numerical simulation of the measurement and processing workflow. First we show that mapping the time-variable field on a monthly basis would require a noise level below 5mE /√{Hz } . The mission scenarios are therefore focused on the static field, like GOCE. Second, the stringent requirement on the angular velocity of a one-arm gradiometer, which must not exceed 10-6 rad/s, leads to two possible modes of operation of the CAI gradiometer: the nadir and the quasi-inertial mode. In the nadir mode, which corresponds to the usual Earth-pointing satellite attitude, only the gradient Vyy , along the cross-track direction, is measured. In the quasi-inertial mode, the satellite attitude is approximately constant in the inertial reference frame and the 3 diagonal gradients Vxx,Vyy and Vzz are measured. Both modes are successively simulated for a 239 km altitude orbit and the error on the recovered gravity models eventually compared to GOCE solutions. We conclude that for the specific CAI gradiometer design assumed in this paper, only the quasi-inertial mode scenario would be able to significantly outperform GOCE results at the cost of technically challenging requirements on the orbit and attitude control.

Use of Massive Parallel Computing Libraries in the Context of Global Gravity Field Determination from Satellite Data

NASA Astrophysics Data System (ADS)

Brockmann, J. M.; Schuh, W.-D.

2011-07-01

The estimation of the global Earth's gravity field parametrized as a finite spherical harmonic series is computationally demanding. The computational effort depends on the one hand on the maximal resolution of the spherical harmonic expansion (i.e. the number of parameters to be estimated) and on the other hand on the number of observations (which are several millions for e.g. observations from the GOCE satellite missions). To circumvent these restrictions, a massive parallel software based on high-performance computing (HPC) libraries as ScaLAPACK, PBLAS and BLACS was designed in the context of GOCE HPF WP6000 and the GOCO consortium. A prerequisite for the use of these libraries is that all matrices are block-cyclic distributed on a processor grid comprised by a large number of (distributed memory) computers. Using this set of standard HPC libraries has the benefit that once the matrices are distributed across the computer cluster, a huge set of efficient and highly scalable linear algebra operations can be used.

Theoretical and numerical investigations towards a new geoid model for the Mediterranean Sea - The GEOMED2 project

NASA Astrophysics Data System (ADS)

Barzaghi, Riccardo; Vergos, Georgios S.; Albertella, Alberta; Carrion, Daniela; Cazzaniga, Noemi; Tziavos, Ilias N.; Grigoriadis, Vassilios N.; Natsiopoulos, Dimitrios A.; Bruinsma, Sean; Bonvalot, Sylvain; Lequentrec-Lalancette, Marie-Françoise; Bonnefond, Pascal; Knudsen, Per; Andersen, Ole; Simav, Mehmet; Yildiz, Hasan; Basic, Tomislav; Gil, Antonio J.

2016-04-01

The unique features of the Mediterranean Sea, with its large gravity variations, complex circulation, and geodynamic peculiarities have always constituted this semi-enclosed sea area as a unique geodetic, geodynamics and ocean laboratory. The main scope of the GEOMED 2 project is the collection of all available gravity, topography/bathymetry and satellite altimetry data in order to improve the representation of the marine geoid and estimate the Mean Dynamic sea surface Topography (MDT) and the circulation with higher accuracy and resolution. Within GEOMED2, the data employed are land and marine gravity data, GOCE/GRACE based Global Geopotential Models and a combination after proper validation of MISTRAL, HOMONIM and SRTM/bathymetry terrain models. In this work we present the results achieved for an inner test region spanning the Adriatic Sea area, bounded between 36o < φ < 48o and 10o < λ < 22o. Within this test region, the available terrain/bathymetry models have been evaluated in terms of their contribution to geoid modeling, the processing methodologies have been tested in terms of the provided geoid accuracy and finally some preliminary results on the MDT determination have been compiled. The aforementioned will server as the guide for the Mediterranean-wide marine geoid estimation. The processing methodology was based on the well-known remove-compute-restore method following both stochastic and spectral methods. Classic least-squares collocation (LSC) with errors has been employed, along with fast Fourier transform (FFT)-based techniques, the Least-Squares Modification of Stokes' Formula (KTH) method and windowed LSC. All methods have been evaluated against in-situ collocated GPS/Levelling geoid heights, using EGM2008 as a reference, in order to conclude on the one(s) to be used for the basin-wide geoid evaluation.

On the capability of Swarm for surface mass variation monitoring: Quantitative assessment based on orbit information from CHAMP, GRACE and GOCE

NASA Astrophysics Data System (ADS)

Baur, Oliver; Weigelt, Matthias; Zehentner, Norbert; Mayer-Gürr, Torsten; Jäggi, Adrian

2014-05-01

In the last decade, temporal variations of the gravity field from GRACE observations have become one of the most ubiquitous and valuable sources of information for geophysical and environmental studies. In the context of global climate change, mass balance of the Arctic and Antarctic ice sheets gained particular attention. Because GRACE has outlived its predicted lifetime by several years already, it is very likely that a gap between GRACE and its successor GRACE follow-on (supposed to be launched in 2017, at the earliest) occurs. The Swarm mission - launched on November 22, 2013 - is the most promising candidate to bridge this potential gap, i.e., to directly acquire large-scale mass variation information on the Earth's surface in case of a gap between the present GRACE and the upcoming GRACE follow-on projects. Although the magnetometry mission Swarm has not been designed for gravity field purposes, its three satellites have the characteristics for such an endeavor: (i) low, near-circular and near-polar orbits, (ii) precise positioning with high-quality GNSS receivers, (iii) on-board accelerometers to measure the influence of non-gravitational forces. Hence, from an orbit analysis point of view the Swarm satellites are comparable to the CHAMP, GRACE and GOCE spacecraft. Indeed and as data analysis from CHAMP has been shown, the detection of annual signals and trends from orbit analysis is possible for long-wavelength features of the gravity field, although the accuracy associated with the inter-satellite GRACE measurements cannot be reached. We assess the capability of the (non-dedicated) mission Swarm for mass variation detection in a real-case environment (opposed to simulation studies). For this purpose, we "approximate" the Swarm scenario by the GRACE+CHAMP and GRACE+GOCE constellations. In a first step, kinematic orbits of the individual satellites are derived from GNSS observations. From these orbits, we compute monthly combined GRACE+CHAMP and GRACE+GOCE time-variable gravity fields; sophisticated techniques based on Kalman filtering are applied to reduce noise in the time series. Finally, we infer mass variation in selected areas from to gravity signal. These results are compared to the findings obtained from mass variation detection exploiting CSR-RL05 gravity fields; due to their superior quality (which is due to the fact that they are derived from inter-satellite GRACE measurements), the CSR-RL05 solutions serve as benchmark. Our quantitative assessment shows the potential and limitations of what can be expected from Swarm with regard to surface mass variation monitoring.

Satellite observations of atmosphere-ionosphere vertical coupling by gravity waves

NASA Astrophysics Data System (ADS)

Trinh, Thai; Ern, Manfred; Preusse, Peter; Riese, Martin

2017-04-01

The Earth's thermosphere/ionosphere (T/I) is strongly influenced by various processes from above as well as from below. One of the most important processes from below is vertical coupling by atmospheric waves. Among these waves, gravity waves (GWs) excited in the lower atmosphere, mainly in the troposphere and tropopause region, are likely essential for the mean state of the T/I system. The penetration of GWs into the T/I system is however not well understood in modeling as well as observations. In this work, we analyze the correlation between different GW parameters at lower altitudes (below 90 km) and GW induced perturbations in the T/I. At lower altitudes, GW parameters are derived from temperature observations of the Sounding of the Atmosphere using Broadband Emission Radiometry (SABER). In the T/I, GW induced perturbations of neutral density measured by Gravity field and Ocean Circulation Explorer (GOCE) and CHAllenging Minisatellite Payload (CHAMP) are analyzed. Interestingly, we find positive correlations between the spatial distributions at low altitudes (i.e. below 90km) and the spatial distributions of GW-induced density fluctuations in the T/I (at 200km and above), which suggests that many waves seen in the T/I have their origins in the troposphere or lower stratosphere. It is also indicated that mountain waves generated near the Andes and Antarctic Peninsula propagate up to the T/I. Strong positive correlations between GW perturbations in the T/I and GW parameters at 30 km are mainly found at mid latitudes, which may be an indicator of propagation of convectively generated GWs. Increase of correlation starting from 70 km in many cases shows that filtering of the GW distribution by the background atmosphere is very important. Processes that are likely involved are GW dissipation, generation of secondary GWs, as well as horizontal propagation of GWs. Limitations of our method and of the observations are also discussed.

Alenia Spazio: Space Programs for Solar System Exploration .

NASA Astrophysics Data System (ADS)

Ferri, A.

Alenia Spazio is the major Italian space industry and one of the largest in Europe, with 2,400 highly skilled employees and 16,000 square meters of clean rooms and laboratories for advanced technological research that are among the most modern and well-equipped in Europe. The company has wide experience in the design, development, assembly, integration, verification and testing of complete space systems: satellites for telecommunications and navigation, remote sensing, meteorology and scientific applications; manned systems and space infrastructures; launch, transport and re-entry systems, and control centres. Alenia Spazio has contributed to the construction of over 200 satellites and taken part in the most important national and international space programmes, from the International Space Station to the new European global navigation system Galileo. Focusing on Solar System exploration, in the last 10 years the Company took part, with different roles, to the major European and also NASA missions in the field: Rosetta, Mars Express, Cassini; will soon take part in Venus Express, and is planning the future with Bepi Colombo, Solar Orbiter, GAIA and Exomars. In this paper, as in the presentation, a very important Earth Observation mission is also presented: GOCE. All in all, the Earth is by all means part of the Solar system as well and we like to see it as a planet to be explored.

A new degree-2190 (10 km resolution) gravity field model for Antarctica developed from GRACE, GOCE and Bedmap2 data

NASA Astrophysics Data System (ADS)

Hirt, Christian; Rexer, Moritz; Scheinert, Mirko; Pail, Roland; Claessens, Sten; Holmes, Simon

2016-02-01

The current high-degree global geopotential models EGM2008 and EIGEN-6C4 resolve gravity field structures to ˜ 10 km spatial scales over most parts of the of Earth's surface. However, a notable exception is continental Antarctica, where the gravity information in these and other recent models is based on satellite gravimetry observations only, and thus limited to about ˜ 80-120 km spatial scales. Here, we present a new degree-2190 global gravity model (GGM) that for the first time improves the spatial resolution of the gravity field over the whole of continental Antarctica to ˜ 10 km spatial scales. The new model called SatGravRET2014 is a combination of recent Gravity Recovery and Climate Experiment (GRACE) and Gravity field and steady-state Ocean Circulation Explorer (GOCE) satellite gravimetry with gravitational signals derived from the 2013 Bedmap2 topography/ice thickness/bedrock model with gravity forward modelling in ellipsoidal approximation. Bedmap2 is a significantly improved description of the topographic mass distribution over the Antarctic region based on a multitude of topographic surveys, and a well-suited source for modelling short-scale gravity signals as we show in our study. We describe the development of SatGravRET2014 which entirely relies on spherical harmonic modelling techniques. Details are provided on the least-squares combination procedures and on the conversion of topography to implied gravitational potential. The main outcome of our work is the SatGravRET2014 spherical harmonic series expansion to degree 2190, and derived high-resolution grids of 3D-synthesized gravity and quasigeoid effects over the whole of Antarctica. For validation, six data sets from the IAG Subcommission 2.4f "Gravity and Geoid in Antarctica" (AntGG) database were used comprising a total of 1,092,981 airborne gravimetric observations. All subsets consistently show that the Bedmap2-based short-scale gravity modelling improves the agreement over satellite-only data considerably (improvement rates ranging between 9 and 75 % with standard deviations from residuals between SatGravRET2014 and AntGG gravity ranging between 8 and 25 mGal). For comparison purposes, a degree-2190 GGM was generated based on the year-2001 Bedmap1 (using the ETOPO1 topography) instead of 2013 Bedmap2 topography product. Comparison of both GGMs against AntGG consistently reveals a closer fit over all test areas when Bedmap2 is used. This experiment provides evidence for clear improvements in Bedmap2 topographic information over Bedmap1 at spatial scales of ˜ 80-10 km, obtained from independent gravity data used as validation tool. As a general conclusion, our modelling effort fills—in approximation—some gaps in short-scale gravity knowledge over Antarctica and demonstrates the value of the Bedmap2 topography data for short-scale gravity refinement in GGMs. SatGravRET2014 can be used, e.g. as a reference model for future gravity modelling efforts over Antarctica, e.g. as foundation for a combination with the AntGG data set to obtain further improved gravity information.

Space-Wise approach for airborne gravity data modelling

NASA Astrophysics Data System (ADS)

Sampietro, D.; Capponi, M.; Mansi, A. H.; Gatti, A.; Marchetti, P.; Sansò, F.

2017-05-01

Regional gravity field modelling by means of remove-compute-restore procedure is nowadays widely applied in different contexts: it is the most used technique for regional gravimetric geoid determination, and it is also used in exploration geophysics to predict grids of gravity anomalies (Bouguer, free-air, isostatic, etc.), which are useful to understand and map geological structures in a specific region. Considering this last application, due to the required accuracy and resolution, airborne gravity observations are usually adopted. However, due to the relatively high acquisition velocity, presence of atmospheric turbulence, aircraft vibration, instrumental drift, etc., airborne data are usually contaminated by a very high observation error. For this reason, a proper procedure to filter the raw observations in both the low and high frequencies should be applied to recover valuable information. In this work, a software to filter and grid raw airborne observations is presented: the proposed solution consists in a combination of an along-track Wiener filter and a classical Least Squares Collocation technique. Basically, the proposed procedure is an adaptation to airborne gravimetry of the Space-Wise approach, developed by Politecnico di Milano to process data coming from the ESA satellite mission GOCE. Among the main differences with respect to the satellite application of this approach, there is the fact that, while in processing GOCE data the stochastic characteristics of the observation error can be considered a-priori well known, in airborne gravimetry, due to the complex environment in which the observations are acquired, these characteristics are unknown and should be retrieved from the dataset itself. The presented solution is suited for airborne data analysis in order to be able to quickly filter and grid gravity observations in an easy way. Some innovative theoretical aspects focusing in particular on the theoretical covariance modelling are presented too. In the end, the goodness of the procedure is evaluated by means of a test on real data retrieving the gravitational signal with a predicted accuracy of about 0.4 mGal.

Adolescents' Computer Mediated Learning and Influences on Inter-Personal Relationships

ERIC Educational Resources Information Center

Miloseva, Lence; Page, Tom; Lehtonen, Miika; Marelja, Jozefina; Thorsteinsson, Gisli

2010-01-01

This study reports the findings of the several projects initiated at the Faculty of Education, Goce Delcev University, Stip, to investigate the motivation skills, but is uniquely specific to as inter, personal relationships and resources that influence the learner's participation in the teaching/learning process in the context of online-learning…

Nonlinear diffusion filtering of the GOCE-based satellite-only MDT

NASA Astrophysics Data System (ADS)

Čunderlík, Róbert; Mikula, Karol

2015-04-01

A combination of the GRACE/GOCE-based geoid models and mean sea surface models provided by satellite altimetry allows modelling of the satellite-only mean dynamic topography (MDT). Such MDT models are significantly affected by a stripping noise due to omission errors of the spherical harmonics approach. Appropriate filtering of this kind of noise is crucial in obtaining reliable results. In our study we use the nonlinear diffusion filtering based on a numerical solution to the nonlinear diffusion equation on closed surfaces (e.g. on a sphere, ellipsoid or the discretized Earth's surface), namely the regularized surface Perona-Malik model. A key idea is that the diffusivity coefficient depends on an edge detector. It allows effectively reduce the noise while preserve important gradients in filtered data. Numerical experiments present nonlinear filtering of the satellite-only MDT obtained as a combination of the DTU13 mean sea surface model and GO_CONS_GCF_2_DIR_R5 geopotential model. They emphasize an adaptive smoothing effect as a principal advantage of the nonlinear diffusion filtering. Consequently, the derived velocities of the ocean geostrophic surface currents contain stronger signal.

Recovering the time-variable gravitational field using satellite gradiometry: requirements and gradiometer concept

NASA Astrophysics Data System (ADS)

Douch, Karim; Müller, Jürgen; Heinzel, Gerhard; Wu, Hu

2017-04-01

The successful GRACE mission and its far-reaching benefits have highlighted the interest to continue and extend the mapping of the Earth's time-variable gravitational field with follow-on missions and ideally a higher spatiotemporal resolution. Here, we would like to put forward satellite gravitational gradiometry as an alternative solution to satellite-to-satellite tracking for future missions. Besides the higher sensitivity to smaller scales compared to GRACE-like missions, a gradiometry mission would only require one satellite and would provide a direct estimation of a functional of the gravitational field. GOCE, the only gradiometry mission launched so far, was not sensitive enough to map the time-variable part of the gravity field. However, the unprecedented precision of the state-of-the-art optical metrology system on-board the LISA PATHFINDER satellite has opened the way to more performant space inertial sensors. We will therefore examine whether it is technically possible to go beyond GOCE performances and to quantify to what extent the time-variable gravitational field could be determined. First, we derive the requirements on the knowledge of the attitude and the position of the satellite and on the measured gradients in terms of sensitivity and calibration accuracy for a typical repeat low-orbit. We conclude in particular that a noise level smaller than 0.1 mE/√Hz- is required in the measurement bandwidth [5x10-4 ; 10-2]Hz so as to be sensitive to the time-variable gravity signal. We introduce then the design and characteristics of the new gradiometer concept and give an assessment of its noise budget. Contrary to the GOCE electrostatic gradiometer, the position of the test-mass in the accelerometer is measured here by laser interferometry rather than by a capacitive readout system, which improves the overall measurement chain. Finally, the first results of a performance analysis carried out thanks to an end-to-end simulator are discussed and compared to the previously defined requirements.

Gravity gradient preprocessing at the GOCE HPF

NASA Astrophysics Data System (ADS)

Bouman, J.; Rispens, S.; Gruber, T.; Schrama, E.; Visser, P.; Tscherning, C. C.; Veicherts, M.

2009-04-01

One of the products derived from the GOCE observations are the gravity gradients. These gravity gradients are provided in the Gradiometer Reference Frame (GRF) and are calibrated in-flight using satellite shaking and star sensor data. In order to use these gravity gradients for application in Earth sciences and gravity field analysis, additional pre-processing needs to be done, including corrections for temporal gravity field signals to isolate the static gravity field part, screening for outliers, calibration by comparison with existing external gravity field information and error assessment. The temporal gravity gradient corrections consist of tidal and non-tidal corrections. These are all generally below the gravity gradient error level, which is predicted to show a 1/f behaviour for low frequencies. In the outlier detection the 1/f error is compensated for by subtracting a local median from the data, while the data error is assessed using the median absolute deviation. The local median acts as a high-pass filter and it is robust as is the median absolute deviation. Three different methods have been implemented for the calibration of the gravity gradients. All three methods use a high-pass filter to compensate for the 1/f gravity gradient error. The baseline method uses state-of-the-art global gravity field models and the most accurate results are obtained if star sensor misalignments are estimated along with the calibration parameters. A second calibration method uses GOCE GPS data to estimate a low degree gravity field model as well as gravity gradient scale factors. Both methods allow to estimate gravity gradient scale factors down to the 10-3 level. The third calibration method uses high accurate terrestrial gravity data in selected regions to validate the gravity gradient scale factors, focussing on the measurement band. Gravity gradient scale factors may be estimated down to the 10-2 level with this method.

Isostatic GOCE Moho model for Iran

NASA Astrophysics Data System (ADS)

Eshagh, Mehdi; Ebadi, Sahar; Tenzer, Robert

2017-05-01

One of the major issues associated with a regional Moho recovery from the gravity or gravity-gradient data is the optimal choice of the mean compensation depth (i.e., the mean Moho depth) for a certain area of study, typically for orogens characterised by large Moho depth variations. In case of selecting a small value of the mean compensation depth, the pattern of deep Moho structure might not be reproduced realistically. Moreover, the definition of the mean compensation depth in existing isostatic models affects only low-degrees of the Moho spectrum. To overcome this problem, in this study we reformulate the Sjöberg and Jeffrey's methods of solving the Vening-Meinesz isostatic problem so that the mean compensation depth contributes to the whole Moho spectrum. Both solutions are then defined for the vertical gravity gradient, allowing estimating the Moho depth from the GOCE satellite gravity-gradiometry data. Moreover, gravimetric solutions provide realistic results only when a priori information on the crust and upper mantle structure is known (usually from seismic surveys) with a relatively good accuracy. To investigate this aspect, we formulate our gravimetric solutions for a variable Moho density contrast to account for variable density of the uppermost mantle below the Moho interface, while taking into consideration also density variations within the sediments and consolidated crust down to the Moho interface. The developed theoretical models are applied to estimate the Moho depth from GOCE data at the regional study area of the Iranian tectonic block, including also parts of surrounding tectonic features. Our results indicate that the regional Moho depth differences between Sjöberg and Jeffrey's solutions, reaching up to about 3 km, are caused by a smoothing effect of Sjöberg's method. The validation of our results further shows a relatively good agreement with regional seismic studies over most of the continental crust, but large discrepancies are detected under the Oman Sea and the Makran subduction zone. We explain these discrepancies by a low quality of seismic data offshore.

Report on the Workshop and Regular Meeting of the Imode-CKD and Bcmolmed Marie Curie Training and Research Programs.

PubMed

Krochmal, Magdalena; Cisek, Katryna; Markoska, Katerina; Spasovski, Goce; Vlahou, Antonia

2015-01-01

A Workshop and Regular Meeting of the Marie Curie Training and Research Programs iMODECKD (Identification of the Molecular Determinants of established Chronic Kidney Disease) and BCMolMed (Molecular Medicine for Bladder Cancer) was held from 20-22 March at the Macedonian Academy of Science and Arts (MASA). The meeting was hosted by the participating center University of Skopje (SKO) - Goce Spasovski and MASA - Momir Polenakovic (R. Macedonia). The representative from MASA proteomic research center - Katerina Davalieva (R. Macedonia) had presentation on proteomic research in prostate cancer (PCa). 40 researchers from 13 different countries participated at the meeting. The Workshop was devoted on "Chronic Kidney Disease: Clinical Management issues", and consisted of 15 oral presentations given by nephrologists and experts in the field of CKD. Raymond Vanholder (Belgium) - past president of ERA-EDTA had a keynote lecture on "CKD: Questions that need to be answered and are not (or at least not entirely)". The workshop continued in four sessions with lectures from Alberto Ortiz (Spain), Olivera Stojceva-Taneva (R. Macedonia), Dimitrios Goumenos (Greece), Joachim Beige (Germany), Marian Klinger (Poland), Goce Spasovski (R. Macedonia), Joachim Jankowski (Germany), Adalbert Schiller (Romania), Robert Johnson (USA), Franco Ferrario (Italy), Ivan Rychlik (Czech Republic), Fulvio Magni (Italy) and Giovambattista Capasso (Italy), all covering a training theme. Within the meeting there were two lectures on complimentary skills for ethics in science and career advancement from two principal investigators - Goce Spasovski (R. Macedonia) and Joost Schanstra (France). During the Regular Meeting, 13 PhD students i.e. Early Stage Researchers and one Experienced Researcher from both Programs presented their work and progress within iMODE-CKD and BCMolMed projects. This meeting was a great opportunity to exchange experience and ideas in the field of systems biology approaches and translational medicine and planning future collaboration.

Photocatalytic discoloration of Acid Red 14 aqueous solution using titania nanoparticles immobilized on graphene oxide fabricated plate.

PubMed

Akerdi, Abdollah Gholami; Bahrami, S Hajir; Arami, Mokhtar; Pajootan, Elmira

2016-09-01

Textile industry consumes remarkable amounts of water during various operations. A significant portion of the water discharge to environment is in the form of colored contaminant. The present research reports the photocatalytic degradation of anionic dye effluent using immobilized TiO2 nanoparticle on graphene oxide (GO) fabricated carbon electrodes. Acid Red 14 (AR 14) was used as model compound. Graphene oxide nanosheets were synthesized from graphite powder using modified Hummer's method. The nanosheets were characterized with field emission scanning electron microscope (FESEM) images, X-ray diffraction (XRD) and FTIR spectrum. The GO nanoparticles were deposited on carbon electrode (GO-CE) by electrochemical deposition (ECD) method and used as catalyst bed. TiO2 nanoparticles were fixed on the bed (GO-CE- TiO2) with thermal process. Photocatalytic processes were carried out using a 500 ml solution containing dye in batch mode. Each photocatalytic treatment were carried out for 120 min. Effect of dye concentration (mg/L), pH of solution, time (min) and TiO2 content (g/L) on the photocatalytic decolorization was investigated. Copyright © 2016 Elsevier Ltd. All rights reserved.

GOCO05c: A New Combined Gravity Field Model Based on Full Normal Equations and Regionally Varying Weighting

NASA Astrophysics Data System (ADS)

Fecher, T.; Pail, R.; Gruber, T.

2017-05-01

GOCO05c is a gravity field model computed as a combined solution of a satellite-only model and a global data set of gravity anomalies. It is resolved up to degree and order 720. It is the first model applying regionally varying weighting. Since this causes strong correlations among all gravity field parameters, the resulting full normal equation system with a size of 2 TB had to be solved rigorously by applying high-performance computing. GOCO05c is the first combined gravity field model independent of EGM2008 that contains GOCE data of the whole mission period. The performance of GOCO05c is externally validated by GNSS-levelling comparisons, orbit tests, and computation of the mean dynamic topography, achieving at least the quality of existing high-resolution models. Results show that the additional GOCE information is highly beneficial in insufficiently observed areas, and that due to the weighting scheme of individual data the spectral and spatial consistency of the model is significantly improved. Due to usage of fill-in data in specific regions, the model cannot be used for physical interpretations in these regions.

Airborne geophysical surveys of unexplored regions of Antarctica - results of the ESA PolarGap campaign

NASA Astrophysics Data System (ADS)

Forsberg, R.; Olesen, A. V.; Ferraccioli, F.; Jordan, T. A.; Matsuoka, K.

2016-12-01

Major airborne geophysical surveys have recently mapped large unexplored regions in the interior of East Antarctica, in a Danish-UK-Norwegian cooperation. Long-range aerogeophysics data have been collected both over the Recovery Lakes region (2012/13), as well as around the Pole (2015/16). The primary purpose of these campaigns was to map gravity to fill-in data voids in global gravity field models and augment results from the European Space Agency GOCE gravity field satellite mission. Additionally magnetic, ice-penetrating radar and lidar data are used to explore and understand the subglacial topography and geological setting, providing an improved foundation for ice sheet modeling. The most recent ESA-sponsored Polar Gap project used a BAS Twin-Otter aircraft equipped with both spring gravimeter and IMU gravity sensors, magnetometers, ice penetrating radar over the essentially unmapped regions of the GOCE polar gap. Additional detailed flights over the subglacial Recovery Lakes region, followed up earlier 2013 flights over this region. The operations took place from two field camps (near Recovery Lakes and Thiel Mountains), as well as from the Amundsen-Scott South Pole station, thanks to a special arrangement with NSF. In addition to the airborne geophysics program, data with an ESA Ku-band radar were also acquired, in support of the CryoSat-2 mission, and scanning lidar collected across the polar gap, beyond the coverage of IceSat. In the talk we outline the Antarctic field operations, and show first results of the campaign, including performance of the gravity sensors, with comparison to limited existing data in the region (e.g., AGAP, IceBridge), as well as examples of lidar, magnetics and radar data. Significant new features detected from the geophysical data includes an extensive subglacial valley system between the Pole and the Filchner-Ronne ice shelf region, as well as extensive subglacial mountains, both consistent with observed ice stream patterns in the region. New data over the Recovery Lakes confirm the tectonic constraints on the lake system, and also hightlight the importantance of relatively dense flight tracks to constrain local subglacial hydrology.

New evidence about the subduction of the Copiapó ridge beneath South America, and its connection with the Chilean-Pampean flat slab, tracked by satellite GOCE and EGM2008 models

NASA Astrophysics Data System (ADS)

Álvarez, Orlando; Gimenez, Mario; Folguera, Andres; Spagnotto, Silvana; Bustos, Emilce; Baez, Walter; Braitenberg, Carla

2015-11-01

Satellite-only gravity measurements and those integrated with terrestrial observations provide global gravity field models of unprecedented precision and spatial resolution, allowing the analysis of the lithospheric structure. We used the model EGM2008 (Earth Gravitational Model) to calculate the gravity anomaly and the vertical gravity gradient in the South Central Andes region, correcting these quantities by the topographic effect. Both quantities show a spatial relationship between the projected subduction of the Copiapó aseismic ridge (located at about 27°-30° S), its potential deformational effects in the overriding plate, and the Ojos del Salado-San Buenaventura volcanic lineament. This volcanic lineament constitutes a projection of the volcanic arc toward the retroarc zone, whose origin and development were not clearly understood. The analysis of the gravity anomalies, at the extrapolated zone of the Copiapó ridge beneath the continent, shows a change in the general NNE-trend of the Andean structures to an ENE-direction coincident with the area of the Ojos del Salado-San Buenaventura volcanic lineament. This anomalous pattern over the upper plate is interpreted to be linked with the subduction of the Copiapó ridge. We explore the relation between deformational effects and volcanism at the northern Chilean-Pampean flat slab and the collision of the Copiapó ridge, on the basis of the Moho geometry and elastic thicknesses calculated from the new satellite GOCE data. Neotectonic deformations interpreted in previous works associated with volcanic eruptions along the Ojos del Salado-San Buenaventura volcanic lineament is interpreted as caused by crustal doming, imprinted by the subduction of the Copiapó ridge, evidenced by crustal thickening at the sites of ridge inception along the trench. Finally, we propose that the Copiapó ridge could have controlled the northern edge of the Chilean-Pampean flat slab, due to higher buoyancy, similarly to the control that the Juan Fernandez ridge exerts in the geometry of the flat slab further south.

The GOCE end-to-end system simulator

NASA Astrophysics Data System (ADS)

Catastini, G.; Cesare, S.; de Sanctis, S.; Detoma, E.; Dumontel, M.; Floberghagen, R.; Parisch, M.; Sechi, G.; Anselmi, A.

2003-04-01

The idea of an end-to-end simulator was conceived in the early stages of the GOCE programme, as an essential tool for assessing the satellite system performance, that cannot be fully tested on the ground. The simulator in its present form is under development at Alenia Spazio for ESA since the beginning of Phase B and is being used for checking the consistency of the spacecraft and of the payload specifications with the overall system requirements, supporting trade-off, sensitivity and worst-case analyses, and preparing and testing the on-ground and in-flight calibration concepts. The software simulates the GOCE flight along an orbit resulting from the application of Earth's gravity field, non-conservative environmental disturbances (atmospheric drag, coupling with Earth's magnetic field, etc.) and control forces/torques. The drag free control forces as well as the attitude control torques are generated by the current design of the dedicated algorithms. Realistic sensor models (star tracker, GPS receiver and gravity gradiometer) feed the control algorithms and the commanded forces are applied through realistic thruster models. The output of this stage of the simulator is a time series of Level-0 data, namely the gradiometer raw measurements and spacecraft ancillary data. The next stage of the simulator transforms Level-0 data into Level-1b (gravity gradient tensor) data, by implementing the following steps: - transformation of raw measurements of each pair of accelerometers into common and differential accelerations - calibration of the common and differential accelerations - application of the post-facto algorithm to rectify the phase of the accelerations and to estimate the GOCE angular velocity and attitude - computation of the Level-1b gravity gradient tensor from calibrated accelerations and estimated angular velocity in different reference frames (orbital, inertial, earth-fixed); computation of the spectral density of the error of the tensor diagonal components (measured gravity gradient minus input gravity gradient) in order to verify the requirement on the error of gravity gradient of 4 mE/sqrt(Hz) within the gradiometer measurement bandwidth (5 to 100 mHz); computation of the spectral density of the tensor trace in order to verify the requirement of 4 sqrt(3) mE/sqrt(Hz) within the measurement bandwidth - processing of GPS observations for orbit reconstruction within the required 10m accuracy and for gradiometer measurement geolocation. The current version of the end-to-end simulator, essentially focusing on the gradiometer payload, is undergoing detailed testing based on a time span of 10 days of simulated flight. This testing phase, ending in January 2003, will verify the current implementation and conclude the assessment of numerical stability and precision. Following that, the exercise will be repeated on a longer-duration simulated flight and the lesson learnt so far will be exploited to further improve the simulator's fidelity. The paper will describe the simulator's current status and will illustrate its capabilities for supporting the assessment of the quality of the scientific products resulting from the current spacecraft and payload design.

Satellite observations of middle atmosphere-thermosphere vertical coupling by gravity waves

NASA Astrophysics Data System (ADS)

Trinh, Quang Thai; Ern, Manfred; Doornbos, Eelco; Preusse, Peter; Riese, Martin

2018-03-01

Atmospheric gravity waves (GWs) are essential for the dynamics of the middle atmosphere. Recent studies have shown that these waves are also important for the thermosphere/ionosphere (T/I) system. Via vertical coupling, GWs can significantly influence the mean state of the T/I system. However, the penetration of GWs into the T/I system is not fully understood in modeling as well as observations. In the current study, we analyze the correlation between GW momentum fluxes observed in the middle atmosphere (30-90 km) and GW-induced perturbations in the T/I. In the middle atmosphere, GW momentum fluxes are derived from temperature observations of the Sounding of the Atmosphere using Broadband Emission Radiometry (SABER) satellite instrument. In the T/I, GW-induced perturbations are derived from neutral density measured by instruments on the Gravity field and Ocean Circulation Explorer (GOCE) and CHAllenging Minisatellite Payload (CHAMP) satellites. We find generally positive correlations between horizontal distributions at low altitudes (i.e., below 90 km) and horizontal distributions of GW-induced density fluctuations in the T/I (at 200 km and above). Two coupling mechanisms are likely responsible for these positive correlations: (1) fast GWs generated in the troposphere and lower stratosphere can propagate directly to the T/I and (2) primary GWs with their origins in the lower atmosphere dissipate while propagating upwards and generate secondary GWs, which then penetrate up to the T/I and maintain the spatial patterns of GW distributions in the lower atmosphere. The mountain-wave related hotspot over the Andes and Antarctic Peninsula is found clearly in observations of all instruments used in our analysis. Latitude-longitude variations in the summer midlatitudes are also found in observations of all instruments. These variations and strong positive correlations in the summer midlatitudes suggest that GWs with origins related to convection also propagate up to the T/I. Different processes which likely influence the vertical coupling are GW dissipation, possible generation of secondary GWs, and horizontal propagation of GWs. Limitations of the observations as well as of our research approach are discussed.

Airborne surveys in the Arctic and Antarctic for geophysics, sea-ice thickness, and CryoSat validation

NASA Astrophysics Data System (ADS)

Forsberg, R.; Olesen, A. V.; Hvidegaard, S.; Skourup, H.

2010-12-01

Airborne laser and radar measurements over the Greenland ice sheet, Svalbard, and adjacent parts of the Arctic Ocean have been carried out by DTU-Space in a number of recent Danish/Greenlandic and European project campaigns, with the purpose to monitor ice sheet and sea-ice changes, support of Greenland societal needs (oil exploration and hydropower), and support of CryoSat pre-launch calibration and validation campaigns. The Arctic campaigns have been done using a Twin-Otter aircraft, carrying laser scanners and various radars. Since 2009 a new program of long-range gravity and magnetic surveys have been initiated using a Basler DC3 aircraft for large-scale surveys in the Arctic Ocean and Antarctica, with the 2010 cooperative Danish-Argentinean-Chilean-US ICEGRAV survey of the Antarctic Peninsula additionally including a UTIG 60 MHz ice-penetrating radar. In the paper we outline the recent and upcoming airborne survey activities, outline the usefulness of the airborne data for satellite validation (CryoSat and GOCE), and give examples of measurements and comparisons to satellite and in-situ data.

Exploring the Impact of Students' Learning Approach on Collaborative Group Modeling of Blood Circulation

ERIC Educational Resources Information Center

Lee, Shinyoung; Kang, Eunhee; Kim, Heui-Baik

2015-01-01

This study aimed to explore the effect on group dynamics of statements associated with deep learning approaches (DLA) and their contribution to cognitive collaboration and model development during group modeling of blood circulation. A group was selected for an in-depth analysis of collaborative group modeling. This group constructed a model in a…

Exploring Secondary Students' Epistemological Features Depending on the Evaluation Levels of the Group Model on Blood Circulation

ERIC Educational Resources Information Center

Lee, Shinyoung; Kim, Heui-Baik

2014-01-01

The purpose of this study is to identify the epistemological features and model qualities depending on model evaluation levels and to explore the reasoning process behind high-level evaluation through small group interaction about blood circulation. Nine groups of three to four students in the eighth grade participated in the modeling practice.…

Global Gravity Field Determination by Combination of terrestrial and Satellite Gravity Data

NASA Astrophysics Data System (ADS)

Fecher, T.; Pail, R.; Gruber, T.

2011-12-01

A multitude of impressive results document the success of the satellite gravity field mission GOCE with a wide field of applications in geodesy, geophysics and oceanography. The high performance of GOCE gravity field models can be further improved by combination with GRACE data, which is contributing the long wavelength signal content of the gravity field with very high accuracy. An example for such a consistent combination of satellite gravity data are the satellite-only models GOCO01S and GOCO02S. However, only the further combination with terrestrial and altimetric gravity data enables to expand gravity field models up to very high spherical harmonic degrees and thus to achieve a spatial resolution down to 20-30 km. First numerical studies for high-resolution global gravity field models combining GOCE, GRACE and terrestrial/altimetric data on basis of the DTU10 model have already been presented. Computations up to degree/order 600 based on full normal equations systems to preserve the full variance-covariance information, which results mainly from different weights of individual terrestrial/altimetric data sets, have been successfully performed. We could show that such large normal equations systems (degree/order 600 corresponds to a memory demand of almost 1TByte), representing an immense computational challenge as computation time and memory requirements put high demand on computational resources, can be handled. The DTU10 model includes gravity anomalies computed from the global model EGM08 in continental areas. Therefore, the main focus of this presentation lies on the computation of high-resolution combined gravity field models based on real terrestrial gravity anomaly data sets. This is a challenge due to the inconsistency of these data sets, including also systematic error components, but a further step to a real independent gravity field model. This contribution will present our recent developments and progress by using independent data sets at certain land areas, which are combined with DTU10 in the ocean areas, as well as satellite gravity data. Investigations have been made concerning the preparation and optimum weighting of the different data sources. The results, which should be a major step towards a GOCO-C model, will be validated using external gravity field data and by applying different validation methods.

Profiting from Knowledge Circulation: The Gains from University-Industry Interaction

ERIC Educational Resources Information Center

van der Sijde, P. C.

2012-01-01

In this paper the concept of knowledge circulation is explored and placed in a social systems approach that distinguishes four types of "capital": cultural, strategic, network and economic. Knowledge circulation is a form of university-industry interaction that accommodates the objectives of what are, in many respects, unequal partners and…

Analysis of the vibration environment induced on spacecraft components by hypervelocity impact

NASA Astrophysics Data System (ADS)

Pavarin, Daniele

2009-06-01

This paper reports the result achieved within the study ``Spacecraft Disturbances from Hypervelocity Impact'', performed by CISAS and Thales-Alenia Space Italia under European Space Agency contract. The research project investigated the perturbations produced on spacecraft internal components as a consequence of hypervelocity impacts of micrometeoroids and orbital debris on the external walls of the vehicle. Objective of the study was: (i) to set-up a general numerical /experimental procedure to investigate the vibration induced by hypervelocity impact, (ii) to analyze the GOCE mission in order to asses whether the vibration environment induce by the impact of orbital debris and micrometeoroids could jeopardize the mission. The research project was conducted both experimentally and numerically, performing a large number of impact tests on GOCE-like structural configurations and extrapolating the experimental results via numerical simulations based on hydrocode calculations, finite element and statistical energy analysis. As a result, a database was established which correlates the impact conditions in the experimental range (0.6 to 2.3 mm projectiles at 2.5 to 5 km/s) with the shock spectra on selected locations on various types of structural models.The main out coming of the study are: (i) a wide database reporting acceleration values on a wide range of impact condition, (ii) a general numerical methodology to investigate disturbances induced by space debris and micrometeoroids on general satellite structures.

Circulating Tumor Cell and Cell-free Circulating Tumor DNA in Lung Cancer.

PubMed

Nurwidya, Fariz; Zaini, Jamal; Putra, Andika Chandra; Andarini, Sita; Hudoyo, Achmad; Syahruddin, Elisna; Yunus, Faisal

2016-09-01

Circulating tumor cells (CTCs) are tumor cells that are separated from the primary site or metastatic lesion and disseminate in blood circulation. CTCs are considered to be part of the long process of cancer metastasis. As a 'liquid biopsy', CTC molecular examination and investigation of single cancer cells create an important opportunity for providing an understanding of cancer biology and the process of metastasis. In the last decade, we have seen dramatic development in defining the role of CTCs in lung cancer in terms of diagnosis, genomic alteration determination, treatment response and, finally, prognosis prediction. The aims of this review are to understand the basic biology and to review methods of detection of CTCs that apply to the various types of solid tumor. Furthermore, we explored clinical applications, including treatment monitoring to anticipate therapy resistance as well as biomarker analysis, in the context of lung cancer. We also explored the potential use of cell-free circulating tumor DNA (ctDNA) in the genomic alteration analysis of lung cancer.

Thermospheric dynamics during November 21-22, 1981 - Dynamics Explorer measurements and thermospheric general circulation model predictions

NASA Technical Reports Server (NTRS)

Roble, R. G.; Killeen, T. L.; Spencer, N. W.; Heelis, R. A.; Reiff, P. H.

1988-01-01

Time-dependent aurora and magnetospheric convection parameterizations have been derived from solar wind and aurora particle data for November 21-22, 1981, and are used to drive the auroral and magnetospheric convection models that are embedded in the National Center for Atmospheric Research thermospheric general circulation model (TGCM). Neutral wind speeds and transition boundaries between the midlatitude solar-driven circulation and the high-latitude magnetospheric convection-driven circulation are examined on an orbit-by-orbit basis. The results show that TGCM-calculated winds and reversal boundary locations are in generally good agreement with Dynamics Explorer 2 measurements for the orbits studied. This suggests that, at least for this particular period of relatively moderate geomagnetic activity, the TGCM parameterizations on the eveningside of the auroral oval and polar cap are adequate.

Thermospheric recovery during the 5 April 2010 geomagnetic storm

NASA Astrophysics Data System (ADS)

Sheng, Cheng; Lu, Gang; Solomon, Stanley C.; Wang, Wenbin; Doornbos, Eelco; Hunt, Linda A.; Mlynczak, Martin G.

2017-04-01

Thermospheric temperature and density recovery during the 5 April 2010 geomagnetic storm has been investigated in this study. Neutral density recovery as revealed by Thermosphere-Ionosphere-Electrodynamics General Circulation Model (TIEGCM) simulations was slower than observations from GOCE, CHAMP, and GRACE satellites, suggesting that the cooling processes may not be fully represented in the model. The NO radiative cooling rate in TIEGCM was also compared with TIMED/SABER measurements along satellite orbits during this storm period. It was found that the model overestimated the NO cooling rate at low latitudes and underestimated it at high latitudes. The effects of particle precipitation on NO number density and NO cooling rate at high latitudes were examined in detail. Model experiments showed that while NO number density and NO cooling rate do change with different specifications of the characteristic energy of auroral precipitating electrons, neutral temperature and density recovery remain more or less the same. The reaction rates of key NO chemistry were tested as well, and the NO number density between 110 and 150 km was found to be very sensitive to the reaction rate of N(2D) + O2 → NO + O. A temperature-dependent reaction rate for this reaction proposed by Duff et al. (2003) brought the TIEGCM NO cooling rate at high latitudes closer to the SABER observations. With the temperature-dependent reaction rate, the neutral density recovery time became quite close to the observations in the high-latitude Southern Hemisphere. But model-data discrepancies still exist at low latitudes and in the Northern Hemisphere, which calls for further investigation.

2017 Updates: Earth Gravitational Model 2020

NASA Astrophysics Data System (ADS)

Barnes, D. E.; Holmes, S. A.; Ingalls, S.; Beale, J.; Presicci, M. R.; Minter, C.

2017-12-01

The National Geospatial-Intelligence Agency [NGA], in conjunction with its U.S. and international partners, has begun preliminary work on its next Earth Gravitational Model, to replace EGM2008. The new `Earth Gravitational Model 2020' [EGM2020] has an expected public release date of 2020, and will retain the same harmonic basis and resolution as EGM2008. As such, EGM2020 will be essentially an ellipsoidal harmonic model up to degree (n) and order (m) 2159, but will be released as a spherical harmonic model to degree 2190 and order 2159. EGM2020 will benefit from new data sources and procedures. Updated satellite gravity information from the GOCE and GRACE mission, will better support the lower harmonics, globally. Multiple new acquisitions (terrestrial, airborne and shipborne) of gravimetric data over specific geographical areas (Antarctica, Greenland …), will provide improved global coverage and resolution over the land, as well as for coastal and some ocean areas. Ongoing accumulation of satellite altimetry data as well as improvements in the treatment of this data, will better define the marine gravity field, most notably in polar and near-coastal regions. NGA and partners are evaluating different approaches for optimally combining the new GOCE/GRACE satellite gravity models with the terrestrial data. These include the latest methods employing a full covariance adjustment. NGA is also working to assess systematically the quality of its entire gravimetry database, towards correcting biases and other egregious errors. Public release number 15-564

Enriching User-Oriented Class Associations for Library Classification Schemes.

ERIC Educational Resources Information Center

Pu, Hsiao-Tieh; Yang, Chyan

2003-01-01

Explores the possibility of adding user-oriented class associations to hierarchical library classification schemes. Analyses a log of book circulation records from a university library in Taiwan and shows that classification schemes can be made more adaptable by analyzing circulation patterns of similar users. (Author/LRW)

Future geodesy missions: Tethered systems and formation flying

NASA Astrophysics Data System (ADS)

Fontdecaba, Jordi; Sanjurjo, Manuel; Pelaez, Jesus; Metris, Gilles; Exertier, Pierre

Recent gravity field determination missions have shown the possibility of improving our Earth knowledge from space. GRACE has helped to the determination of temporal variations of low and mean degrees of the field while GOCE will improve the precision in the determination of higher degrees. But there is still some needs for geophysics which are not satisfied by these missions. Two areas where improvements must be done are (i) perenniality of the observations, and (ii) determination of temporal variations of higher degrees of the gravity field. These improvements can be achieved thanks to new measurement technologies with higher precision, but also using new observables. Historically, space determination of the gravity field has been done observing the perturbations of the orbit of the satellites. More recently, GRACE has introduced the use of satellite-tosatellite ranging. Goce will use onboard gradiometry. The authors have explored the possibilities of two new technologies for the determination of the gravity field: (i) tethered systems, and (ii) formation flying for all kind of configurations (not just leader-follower). To analyze the possibilities of these technologies, we obtain the covariance matrix of the coefficients of the gravity field for the different observables. This can be done providing some very reasonable hypothesis are accepted. This matrix contains a lot of information concerning the behavior of the observable. In order to obtain the matrix, we use the so-called lumped coefficients approach. We have used this method for three observables (i) tethered systems, (ii) formation flying and (iii) gradiometry (for comparison purposes). Tethers appear as a very long base gradiometers, with very interesting properties, but also very challenging from a technological point of view. One of the major advantages of the tethered systems is their multitask design. Indeed, the same cable can be used for propulsion purposes in some phases of the mission, and for geodesy purposes in other phases. Several studies have been presented using formation flying, but none of them is exhaustive in terms of number of satellites, configuration, and plan of the motion. We study formation flying using differential orbital elements in order to be as general as possible. The advantage of this representation is the possibility to study all sort of initial conditions and reference orbits with a posterior analysis of covariance matrices. Our results show the intrinsic possibilities of these new two systems and their comparison with existing ones. We also define some baseline scenarios for future missions.

Effects of Solar Particle Event-Like Proton Radiation and/or Simulated Microgravity on Circulating Mouse Blood Cells.

PubMed

Romero-Weaver, Ana L; Lin, Liyong; Carabe-Fernandez, Alejandro; Kennedy, Ann R

2014-08-01

Astronauts traveling in space missions outside of low Earth orbit will be exposed for longer times to a microgravity environment. In addition, the increased travel time involved in exploration class missions will result in an increased risk of exposure to significant doses of solar particle event (SPE) radiation. Both conditions could significantly affect the number of circulating blood cells. Therefore, it is critical to determine the combined effects of exposure to both microgravity and SPE radiation. The purpose of the present study was to assess these risks by evaluating the effects of SPE-like proton radiation and/or microgravity, as simulated with the hindlimb unloading (HU) system, on circulating blood cells using mouse as a model system. The results indicate that exposure to HU alone caused minimal or no significant changes in mouse circulating blood cell numbers. The exposure of mice to SPE-like proton radiation with or without HU treatment caused a significant decrease in the number of circulating lymphocytes, granulocytes and platelets. The reduced numbers of circulating lymphocytes, granulocytes, and platelets, resulting from the SPE-like proton radiation exposure, with or without HU treatment, in mice suggest that astronauts participating in exploration class missions may be at greater risk of developing infections and thrombotic diseases; thus, countermeasures may be necessary for these biological endpoints.

Circulating Power and In/Visibility: Layers of Educational Leadership

ERIC Educational Resources Information Center

Mifsud, Denise

2015-01-01

Purpose: The purpose of this paper is to study circulating power and in/visibility. In the unfolding Maltese education scenario of decentralization and school networking, suffused with entrenched power, with added layers of leadership and more subtle levels of accountability, this paper explores the underlying power relations among the top…

Enhanced Arctic Mean Sea Surface and Mean Dynamic Topography including retracked CryoSat-2 Data

NASA Astrophysics Data System (ADS)

Andersen, O. B.; Jain, M.; Stenseng, L.; Knudsen, P.

2014-12-01

A reliable mean sea surface (MSS) is essential to derive a good mean dynamic topography (MDT) and for the estimation of short and long-term changes in the sea surface. The lack of satellite radar altimetry observations above 82 degrees latitude means that existing mean sea surface models have been unreliable in the Arctic Ocean. We here present the latest DTU mean sea surface and mean dynamic topography models combining conventional altimetry with retracked CryoSat-2 data to improve the reliability in the Arctic Ocean. For the derivation of a mean dynamic topography the ESA GOCE derived geoid model have been used to constrain the longer wavelength. We present the retracking of C2 SAR data using various retrackes and how we have been able to combine data from various retrackers under various sea ice conditions. DTU13MSS and DTU13MDT are the newest state of the art global high-resolution models including CryoSat-2 data to extend the satellite radar altimetry coverage up to 88 degrees latitude and through combination with a GOCE geoid model completes coverage all the way to the North Pole. Furthermore the SAR and SARin capability of CryoSat-2 dramatically increases the amount of useable sea surface returns in sea-ice covered areas compared to conventional radar altimeters like ENVISAT and ERS-1/2. With the inclusion of CryoSat-2 data the new mean sea surface is improved by more than 20 cm above 82 degrees latitude compared with the previous generation of mean sea surfaces.

Adaptive topographic mass correction for satellite gravity and gravity gradient data

NASA Astrophysics Data System (ADS)

Holzrichter, Nils; Szwillus, Wolfgang; Götze, Hans-Jürgen

2014-05-01

Subsurface modelling with gravity data includes a reliable topographic mass correction. Since decades, this mandatory step is a standard procedure. However, originally methods were developed for local terrestrial surveys. Therefore, these methods often include defaults like a limited correction area of 167 km around an observation point, resampling topography depending on the distance to the station or disregard the curvature of the earth. New satellite gravity data (e.g. GOCE) can be used for large scale lithospheric modelling with gravity data. The investigation areas can include thousands of kilometres. In addition, measurements are located in the flight height of the satellite (e.g. ~250 km for GOCE). The standard definition of the correction area and the specific grid spacing around an observation point was not developed for stations located in these heights and areas of these dimensions. This asks for a revaluation of the defaults used for topographic correction. We developed an algorithm which resamples the topography based on an adaptive approach. Instead of resampling topography depending on the distance to the station, the grids will be resampled depending on its influence at the station. Therefore, the only value the user has to define is the desired accuracy of the topographic correction. It is not necessary to define the grid spacing and a limited correction area. Furthermore, the algorithm calculates the topographic mass response with a spherical shaped polyhedral body. We show examples for local and global gravity datasets and compare the results of the topographic mass correction to existing approaches. We provide suggestions how satellite gravity and gradient data should be corrected.

A Wind Tunnel Model to Explore Unsteady Circulation Control for General Aviation Applications

NASA Technical Reports Server (NTRS)

Cagle, Christopher M.; Jones, Gregory S.

2002-01-01

Circulation Control airfoils have been demonstrated to provide substantial improvements in lift over conventional airfoils. The General Aviation Circular Control model is an attempt to address some of the concerns of this technique. The primary focus is to substantially reduce the amount of air mass flow by implementing unsteady flow. This paper describes a wind tunnel model that implements unsteady circulation control by pulsing internal pneumatic valves and details some preliminary results from the first test entry.

Are higher degree even zonals really harmful for the LARES/LAGEOS frame-dragging experiment?

NASA Astrophysics Data System (ADS)

Renzetti, G.

2012-08-01

The low-altitude effects of LARES are examined to determined how they can impact the outcome of the hoped 1% frame-dragging measurement in the LARES-LAGEOS experiment. This analysis, based on a different approach than other studies recently appearing in the literature, shows that the spherical harmonics of the Earth gravity field with degree ℓ > 60 may represent a threat because their errors map significantly into LARES orbital disturbances compared to frame-dragging. The GIF48 model was used. It is questionable whether future Earth gravity models by GRACE and GOCE will be of sufficient accuracy.

CryoSat Plus For Oceans: an ESA Project for CryoSat-2 Data Exploitation Over Ocean

NASA Astrophysics Data System (ADS)

Benveniste, J.; Cotton, D.; Clarizia, M.; Roca, M.; Gommenginger, C. P.; Naeije, M. C.; Labroue, S.; Picot, N.; Fernandes, J.; Andersen, O. B.; Cancet, M.; Dinardo, S.; Lucas, B. M.

2012-12-01

The ESA CryoSat-2 mission is the first space mission to carry a space-borne radar altimeter that is able to operate in the conventional pulsewidth-limited (LRM) mode and in the novel Synthetic Aperture Radar (SAR) mode. Although the prime objective of the Cryosat-2 mission is dedicated to monitoring land and marine ice, the SAR mode capability of the Cryosat-2 SIRAL altimeter also presents the possibility of demonstrating significant potential benefits of SAR altimetry for ocean applications, based on expected performance enhancements which include improved range precision and finer along track spatial resolution. With this scope in mind, the "CryoSat Plus for Oceans" (CP4O) Project, dedicated to the exploitation of CryoSat-2 Data over ocean, supported by the ESA STSE (Support To Science Element) programme, brings together an expert European consortium comprising: DTU Space, isardSAT, National Oceanography Centre , Noveltis, SatOC, Starlab, TU Delft, the University of Porto and CLS (supported by CNES),. The objectives of CP4O are: - to build a sound scientific basis for new scientific and operational applications of Cryosat-2 data over the open ocean, polar ocean, coastal seas and for sea-floor mapping. - to generate and evaluate new methods and products that will enable the full exploitation of the capabilities of the Cryosat-2 SIRAL altimeter , and extend their application beyond the initial mission objectives. - to ensure that the scientific return of the Cryosat-2 mission is maximised. In particular four themes will be addressed: -Open Ocean Altimetry: Combining GOCE Geoid Model with CryoSat Oceanographic LRM Products for the retrieval of CryoSat MSS/MDT model over open ocean surfaces and for analysis of mesoscale and large scale prominent open ocean features. Under this priority the project will also foster the exploitation of the finer resolution and higher SNR of novel CryoSat SAR Data to detect short spatial scale open ocean features. -High Resolution Polar Ocean Altimetry: Combination of GOCE Geoid Model with CryoSat Oceanographic SAR Products over polar oceans for the retrieval of CryoSat MSS/MDT and currents circulations system improving the polar tides models and studying the coupling between blowing wind and current pattern. -High Resolution Coastal Zone Altimetry: Exploitation of the finer resolution and higher SNR of novel CryoSat SAR Data to get the radar altimetry closer to the shore exploiting the SARIn mode for the discrimination of off-nadir land targets (e.g. steep cliffs) in the radar footprint from nadir sea return. -High Resolution Sea-Floor Altimetry: Exploitation of the finer resolution and higher SNR of novel CryoSat SAR Data to resolve the weak short-wavelength sea surface signals caused by sea-floor topography elements and to map uncharted sea-mounts/trenches. One of the first project activities is the consolidation of preliminary scientific requirements for the four themes under investigation. This paper will present the CP4O project content and objectives and will address the first initial results from the on-going work to define the scientific requirements.

Weakening of tropical Pacific atmospheric circulation due to anthropogenic forcing

NASA Astrophysics Data System (ADS)

Vecchi, Gabriel A.; Soden, Brian J.; Wittenberg, Andrew T.; Held, Isaac M.; Leetmaa, Ants; Harrison, Matthew J.

2006-05-01

Since the mid-nineteenth century the Earth's surface has warmed, and models indicate that human activities have caused part of the warming by altering the radiative balance of the atmosphere. Simple theories suggest that global warming will reduce the strength of the mean tropical atmospheric circulation. An important aspect of this tropical circulation is a large-scale zonal (east-west) overturning of air across the equatorial Pacific Ocean-driven by convection to the west and subsidence to the east-known as the Walker circulation. Here we explore changes in tropical Pacific circulation since the mid-nineteenth century using observations and a suite of global climate model experiments. Observed Indo-Pacific sea level pressure reveals a weakening of the Walker circulation. The size of this trend is consistent with theoretical predictions, is accurately reproduced by climate model simulations and, within the climate models, is largely due to anthropogenic forcing. The climate model indicates that the weakened surface winds have altered the thermal structure and circulation of the tropical Pacific Ocean. These results support model projections of further weakening of tropical atmospheric circulation during the twenty-first century.

The Measureable Effects of Closing a Branch Library: Circulation, Instruction, and Service Perception

ERIC Educational Resources Information Center

Lange, Jessica; Lannon, Amber; McKinnon, Dawn

2014-01-01

This article explores the closing of the Howard Ross Library of Management at McGill University, Montreal, Canada. We hypothesized that closing a branch library would result in a decline in the use of library services. We measured library service using circulation statistics, library instruction workshop statistics, and data from the online survey…

Regional gravity field modelling from GOCE observables

NASA Astrophysics Data System (ADS)

Pitoňák, Martin; Šprlák, Michal; Novák, Pavel; Tenzer, Robert

2017-01-01

In this article we discuss a regional recovery of gravity disturbances at the mean geocentric sphere approximating the Earth over the area of Central Europe from satellite gravitational gradients. For this purpose, we derive integral formulas which allow converting the gravity disturbances onto the disturbing gravitational gradients in the local north-oriented frame (LNOF). The derived formulas are free of singularities in case of r ≠ R . We then investigate three numerical approaches for solving their inverses. In the initial approach, the integral formulas are firstly modified for solving individually the near- and distant-zone contributions. While the effect of the near-zone gravitational gradients is solved as an inverse problem, the effect of the distant-zone gravitational gradients is computed by numerical integration from the global gravitational model (GGM) TIM-r4. In the second approach, we further elaborate the first scenario by reducing measured gravitational gradients for gravitational effects of topographic masses. In the third approach, we apply additional modification by reducing gravitational gradients for the reference GGM. In all approaches we determine the gravity disturbances from each of the four accurately measured gravitational gradients separately as well as from their combination. Our regional gravitational field solutions are based on the GOCE EGG_TRF_2 gravitational gradients collected within the period from November 1 2009 until January 11 2010. Obtained results are compared with EGM2008, DIR-r1, TIM-r1 and SPW-r1. The best fit, in terms of RMS (2.9 mGal), is achieved for EGM2008 while using the third approach which combine all four well-measured gravitational gradients. This is explained by the fact that a-priori information about the Earth's gravitational field up to the degree and order 180 was used.

Earth Gravitational Model 2020

NASA Astrophysics Data System (ADS)

Barnes, Daniel; Holmes, Simon; Factor, John; Ingalls, Sarah; Presicci, Manny; Beale, James

2017-04-01

The National Geospatial-Intelligence Agency [NGA], in conjunction with its U.S. and international partners, has begun preliminary work on its next Earth Gravitational Model, to replace EGM2008. The new 'Earth Gravitational Model 2020' [EGM2020] has an expected public release date of 2020, and will likely retain the same harmonic basis and resolution as EGM2008. As such, EGM2020 will be essentially an ellipsoidal harmonic model up to degree (n) and order (m) 2159, but will be released as a spherical harmonic model to degree 2190 and order 2159. EGM2020 will benefit from new data sources and procedures. Updated satellite gravity information from the GOCE and GRACE mission, will better support the lower harmonics, globally. Multiple new acquisitions (terrestrial, airborne and ship borne) of gravimetric data over specific geographical areas, will provide improved global coverage and resolution over the land, as well as for coastal and some ocean areas. Ongoing accumulation of satellite altimetry data as well as improvements in the treatment of this data, will better define the marine gravity field, most notably in polar and near-coastal regions. NGA and partners are evaluating different approaches for optimally combining the new GOCE/GRACE satellite gravity models with the terrestrial data. These include the latest methods employing a full covariance adjustment. NGA is also working to assess systematically the quality of its entire gravimetry database, towards correcting biases and other egregious errors where possible, and generating improved error models that will inform the final combination with the latest satellite gravity models. Outdated data gridding procedures have been replaced with improved approaches. For EGM2020, NGA intends to extract maximum value from the proprietary data that overlaps geographically with unrestricted data, whilst also making sure to respect and honor its proprietary agreements with its data-sharing partners. Approved for Public Release, 15-564

Earth Gravitational Model 2020

NASA Astrophysics Data System (ADS)

Barnes, D.; Factor, J. K.; Holmes, S. A.; Ingalls, S.; Presicci, M. R.; Beale, J.; Fecher, T.

2015-12-01

The National Geospatial-Intelligence Agency [NGA], in conjunction with its U.S. and international partners, has begun preliminary work on its next Earth Gravitational Model, to replace EGM2008. The new 'Earth Gravitational Model 2020' [EGM2020] has an expected public release date of 2020, and will likely retain the same harmonic basis and resolution as EGM2008. As such, EGM2020 will be essentially an ellipsoidal harmonic model up to degree (n) and order (m) 2159, but will be released as a spherical harmonic model to degree 2190 and order 2159. EGM2020 will benefit from new data sources and procedures. Updated satellite gravity information from the GOCE and GRACE mission, will better support the lower harmonics, globally. Multiple new acquisitions (terrestrial, airborne and shipborne) of gravimetric data over specific geographical areas, will provide improved global coverage and resolution over the land, as well as for coastal and some ocean areas. Ongoing accumulation of satellite altimetry data as well as improvements in the treatment of this data, will better define the marine gravity field, most notably in polar and near-coastal regions. NGA and partners are evaluating different approaches for optimally combining the new GOCE/GRACE satellite gravity models with the terrestrial data. These include the latest methods employing a full covariance adjustment. NGA is also working to assess systematically the quality of its entire gravimetry database, towards correcting biases and other egregious errors where possible, and generating improved error models that will inform the final combination with the latest satellite gravity models. Outdated data gridding procedures have been replaced with improved approaches. For EGM2020, NGA intends to extract maximum value from the proprietary data that overlaps geographically with unrestricted data, whilst also making sure to respect and honor its proprietary agreements with its data-sharing partners.

A 3D Finite Element Model with Improved Spatial Resolution to Investigate the Effect of Varying Viscosity on Antarctica

NASA Astrophysics Data System (ADS)

Blank, B.; van der Wal, W.; Pappa, F.; Ebbing, J.

2017-12-01

B. Blank1, H. Hu1, W. van der Wal1, F Pappa2, J. Ebbing21Delft University of Technology 2Christian-Albrechts-University of KielSince the beginning of the 2000's time-variable gravity data from GRACE has proved to be an effective method for mapping ice mass loss in Antarctica. However, Glacial Isostatic Adjustment (GIA) models are required to correct for GIA induced mass changes. While most GIA models have adopted an Earth model that only varies radially in parameters, it has long been clear that the Earth structure also varies with longitude and latitude. For this study a new global 3D GIA model has been developed within the finite element software package ABAQUS, which can be modified to operate on a spatial resolution down to 50 km locally. The model is being benchmarked against normal model models for surface loading. It will be used to investigate the effects of a 3D varying lithosphere and upper asthenosphere in Antarctica. Viscosity which will be computed from temperature estimates with laboratory based flow laws. A new 3D temperature map of the Antarctic lithosphere has been developed within ESA's GOCE+ project based on seismic data as well as on GOCE and GRACE inferred gravity gradients. Output from the GIA model with this new temperature estimates will be compared to that of 1D viscosity profiles and other recent 3D viscosity models based on seismic data. From these side to side comparisons we want to investigate the influence of the viscosity map on uplift rates and horizontal movement. Finally the results can be compared to GPS measurement to investigate the validity of all models.

Joint Analysis of GOCE Gravity Gradients Data with Seismological and Geodynamic Observations to Infer Mantle Properties

NASA Astrophysics Data System (ADS)

Metivier, L.; Greff-Lefftz, M.; Panet, I.; Pajot-Métivier, G.; Caron, L.

2014-12-01

Joint inversion of the observed geoid and seismic velocities has been commonly used to constrain the viscosity profile within the mantle as well as the lateral density variations. Recent satellite measurements of the second-order derivatives of the Earth's gravity potential give new possibilities to understand these mantle properties. We use lateral density variations in the Earth's mantle based on slab history or deduced from seismic tomography. The main uncertainties are the relationship between seismic velocity and density -the so-called density/velocity scaling factor- and the variation with depth of the density contrast between the cold slabs and the surrounding mantle, introduced here as a scaling factor with respect to a constant value. The geoid, gravity and gravity gradients at the altitude of the GOCE satellite (about 255 km) are derived using geoid kernels for given viscosity depth profiles. We assume a layered mantle model with viscosity and conversion factor constant in each layer, and we fix the viscosity of the lithosphere. We perform a Monte Carlo search for the viscosity and the density/velocity scaling factor profiles within the mantle which allow to fit the observed geoid, gravity and gradients of gravity. We test a 2-layer, a 3-layer and 4-layer mantle. For each model, we compute the posterior probability distribution of the unknown parameters, and we discuss the respective contributions of the geoid, gravity and gravity gradients in the inversion. Finally, for the best fit, we present the viscosity and scaling factor profiles obtained for the lateral density variations derived from seismic velocities and for slabs sinking into the mantle.

Evaluation of Gravitational Field Models Based on the Laser Range Observation of Low Earth Orbit Satellites

NASA Astrophysics Data System (ADS)

Wang, H. B.; Zhao, C. Y.; Zhang, W.; Zhan, J. W.; Yu, S. X.

2015-09-01

The Earth gravitational filed model is a kind of important dynamic model in satellite orbit computation. In recent years, several space gravity missions have obtained great success, prompting a lot of gravitational filed models to be published. In this paper, 2 classical models (JGM3, EGM96) and 4 latest models, including EIGEN-CHAMP05S, GGM03S, GOCE02S, and EGM2008 are evaluated by being employed in the precision orbit determination (POD) and prediction, based on the laser range observation of four low earth orbit (LEO) satellites, including CHAMP, GFZ-1, GRACE-A, and SWARM-A. The residual error of observation in POD is adopted to describe the accuracy of six gravitational field models. We show the main results as follows: (1) for LEO POD, the accuracies of 4 latest models (EIGEN-CHAMP05S, GGM03S, GOCE02S, and EGM2008) are at the same level, and better than those of 2 classical models (JGM3, EGM96); (2) If taking JGM3 as reference, EGM96 model's accuracy is better in most situations, and the accuracies of the 4 latest models are improved by 12%-47% in POD and 63% in prediction, respectively. We also confirm that the model's accuracy in POD is enhanced with the increasing degree and order if they are smaller than 70, and when they exceed 70 the accuracy keeps stable, and is unrelated with the increasing degree, meaning that the model's degree and order truncated to 70 are sufficient to meet the requirement of LEO orbit computation with centimeter level precision.

Validation of the BASALT model for simulating off-axis hydrothermal circulation in oceanic crust

NASA Astrophysics Data System (ADS)

Farahat, Navah X.; Archer, David; Abbot, Dorian S.

2017-08-01

Fluid recharge and discharge between the deep ocean and the porous upper layer of off-axis oceanic crust tends to concentrate in small volumes of rock, such as seamounts and fractures, that are unimpeded by low-permeability sediments. Basement structure, sediment burial, heat flow, and other regional characteristics of off-axis hydrothermal systems appear to produce considerable diversity of circulation behaviors. Circulation of seawater and seawater-derived fluids controls the extent of fluid-rock interaction, resulting in significant geochemical impacts. However, the primary regional characteristics that control how seawater is distributed within upper oceanic crust are still poorly understood. In this paper we present the details of the two-dimensional (2-D) BASALT (Basement Activity Simulated At Low Temperatures) numerical model of heat and fluid transport in an off-axis hydrothermal system. This model is designed to simulate a wide range of conditions in order to explore the dominant controls on circulation. We validate the BASALT model's ability to reproduce observations by configuring it to represent a thoroughly studied transect of the Juan de Fuca Ridge eastern flank. The results demonstrate that including series of narrow, ridge-parallel fractures as subgrid features produces a realistic circulation scenario at the validation site. In future projects, a full reactive transport version of the validated BASALT model will be used to explore geochemical fluxes in a variety of off-axis hydrothermal environments.

Abandonment, Adoption and Reproductive Disruption: Transitions in Child Circulation in Mexico City, 1880-1910

ERIC Educational Resources Information Center

Blum, Ann S.

2007-01-01

To explore meanings attached to children in Mexican society, this article examines two changing aspects of child circulation, a widespread reproductive disruption to the families of Mexico City's working poor. In the late 1890s, a rapid rise in admissions to the public foundling home was matched by a striking increase in retrievals. At the other…

Three-pattern decomposition of global atmospheric circulation: part II—dynamical equations of horizontal, meridional and zonal circulations

NASA Astrophysics Data System (ADS)

Hu, Shujuan; Cheng, Jianbo; Xu, Ming; Chou, Jifan

2018-04-01

The three-pattern decomposition of global atmospheric circulation (TPDGAC) partitions three-dimensional (3D) atmospheric circulation into horizontal, meridional and zonal components to study the 3D structures of global atmospheric circulation. This paper incorporates the three-pattern decomposition model (TPDM) into primitive equations of atmospheric dynamics and establishes a new set of dynamical equations of the horizontal, meridional and zonal circulations in which the operator properties are studied and energy conservation laws are preserved, as in the primitive equations. The physical significance of the newly established equations is demonstrated. Our findings reveal that the new equations are essentially the 3D vorticity equations of atmosphere and that the time evolution rules of the horizontal, meridional and zonal circulations can be described from the perspective of 3D vorticity evolution. The new set of dynamical equations includes decomposed expressions that can be used to explore the source terms of large-scale atmospheric circulation variations. A simplified model is presented to demonstrate the potential applications of the new equations for studying the dynamics of the Rossby, Hadley and Walker circulations. The model shows that the horizontal air temperature anomaly gradient (ATAG) induces changes in meridional and zonal circulations and promotes the baroclinic evolution of the horizontal circulation. The simplified model also indicates that the absolute vorticity of the horizontal circulation is not conserved, and its changes can be described by changes in the vertical vorticities of the meridional and zonal circulations. Moreover, the thermodynamic equation shows that the induced meridional and zonal circulations and advection transport by the horizontal circulation in turn cause a redistribution of the air temperature. The simplified model reveals the fundamental rules between the evolution of the air temperature and the horizontal, meridional and zonal components of global atmospheric circulation.

Microvibration and Centre-of-Gravity Shift Measurements on Thermally Stressed Thermal-Control Blankets

NASA Astrophysics Data System (ADS)

Magg, Manfred; Grillenbeck, Anton, , Dr.

2004-08-01

Several samples of thermal control blankets were subjected to transient thermal loads in a thermal vacuum chamber in order to study their ability to excite micro- vibrations on a carrier structure and to cause tiny centre- of-gravity shifts. The reason for this investigation was driven by the GOCE project in order to minimize micro- vibrations on-board of the spacecraft while on-orbit. The objectives of this investigation were to better understand the mechanism which may produce micro- vibrations induced by the thermal control blankets, and to identify thermal control blanket lay-ups with minimum micro-vibration activity.

Brain Gain or Brain Circulation? U.S. Doctoral Recipients Returning to South Korea

ERIC Educational Resources Information Center

Lee, Jenny J.; Kim, Dongbin

2010-01-01

This study explored the reasons for current reverse mobility patterns in South Korea and how the country benefits from returning U.S. doctoral recipients in the forms of brain gain and brain circulation. Based on interviews of Korean faculty who studied in the U.S., this study found that while the political economy might help to explain why Korean…

The Southern Ocean's role in ocean circulation and climate transients

NASA Astrophysics Data System (ADS)

Thompson, A. F.; Stewart, A.; Hines, S.; Adkins, J. F.

2017-12-01

The ventilation of deep and intermediate density classes at the surface of the Southern Ocean impacts water mass modification and the air-sea exchange of heat and trace gases, which in turn influences the global overturning circulation and Earth's climate. Zonal variability occurs along the Antarctic Circumpolar Current and the Antarctic margins related to flow-topography interactions, variations in surface boundary conditions, and exchange with northern basins. Information about these zonal variations, and their impact on mass and tracer transport, are suppressed when the overturning is depicted as a two-dimensional (depth-latitude) streamfunction. Here we present an idealized, multi-basin, time-dependent circulation model that applies residual circulation theory in the Southern Ocean and allows for zonal water mass transfer between different ocean basins. This model efficiently determines the temporal evolution of the ocean's stratification, ventilation and overturning strength in response to perturbations in the external forcing. With this model we explore the dynamics that lead to transitions in the circulation structure between multiple, isolated cells and a three-dimensional, "figure-of-eight," circulation in which traditional upper and lower cells are interleaved. The transient model is also used to support a mechanistic explanation of the hemispheric asymmetry and phase lag associated with Dansgaard-Oeschger (DO) events during the last glacial period. In particular, the 200 year lag in southern hemisphere temperatures, following a perturbation in North Atlantic deep water formation, depends critically on the migration of Southern Ocean isopycnal outcropping in response to low-latitude stratification changes. Our results provide a self-consistent dynamical framework to explain various ocean overturning transitions that have occurred over the Earth's last 100,000 years, and motivate an exploration of these mechanisms in more sophisticated climate models.

Immunity against influenza A(H1N1) infections is determined by age at the time of initial strain circulation.

PubMed

Delabre, R M; Salez, N; Lapidus, N; Lemaitre, M; Leruez-Ville, M; de Lamballerie, X; Carrat, F

2017-01-01

We explored age-dependent patterns in haemagglutination inhibition (HI) titre to seasonal [1956 A(H1N1), 1977 A(H1N1), 2007 A(H1N1)] and pandemic [A(H1N1)pdm09] influenza strains using serological data collected from an adult French influenza cohort. Subjects were recruited by their general practitioners from 2008 to 2009 and followed until 2010. We explored age-related differences between strain-specific HI titres using 1053 serological samples collected over the study period from 398 unvaccinated subjects. HI titres against the tested seasonal and pandemic strains were determined using the HI technique. Geometric mean titres (GMTs) were estimated using regression models for interval-censored data. Generalized additive mixed models were fit to log-transformed HI estimates to study the relationship between HI titre and age (age at inclusion and/or age at initial strain circulation). GMT against one strain was consistently highest in the birth cohort exposed to that strain during childhood, with peak titres observed in subjects aged 7-8 years at the time of initial strain circulation. Our results complete previous findings on influenza A(H3N2) strains and identify a strain-dependent relationship between HI titre and age at initial strain circulation.

Circulating microRNA signature in non-alcoholic fatty liver disease: from serum non-coding RNAs to liver histology and disease pathogenesis.

PubMed

Pirola, Carlos J; Fernández Gianotti, Tomas; Castaño, Gustavo O; Mallardi, Pablo; San Martino, Julio; Mora Gonzalez Lopez Ledesma, María; Flichman, Diego; Mirshahi, Faridodin; Sanyal, Arun J; Sookoian, Silvia

2015-05-01

We used a screening strategy of global serum microRNA (miRNA) profiling, followed by a second stage of independent replication and exploration of liver expression of selected miRNAs to study: (1) the circulating miRNA signature associated with non-alcoholic fatty liver disease (NAFLD) progression and predictive power, (2) the role of miRNAs in disease biology and (3) the association between circulating miRNAs and features of the metabolic syndrome. The study used a case-control design and included patients with NAFLD proven through biopsy and healthy controls. Among 84 circulating miRNAs analysed, miR-122, miR-192, miR-19a and miR-19b, miR-125b, and miR-375 were upregulated >2-fold (p<0.05) either in simple steatosis (SS) or non-alcoholic steatohepatitis (NASH). The most dramatic and significant fold changes were observed in the serum levels of miR-122 (7.2-fold change in NASH vs controls and 3.1-fold change in NASH vs SS) and miR-192 (4.4-fold change in NASH vs controls); these results were replicated in the validation set. The majority of serum miR-122 circulate in argonaute2-free forms. Circulating miR-19a/b and miR-125b were correlated with biomarkers of atherosclerosis. Liver miR-122 expression was 10-fold (p<0.03) downregulated in NASH compared with SS and was preferentially expressed at the edge of lipid-laden hepatocytes. In vitro exploration showed that overexpression of miR-122 enhances alanine aminotransferase activity. miR-122 plays a role of physiological significance in the biology of NAFLD; circulating miRNAs mirror the histological and molecular events occurring in the liver. NAFLD has a distinguishing circulating miRNA profile associated with a global dysmetabolic disease state and cardiovascular risk. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

Circulating asymmetric dimethylarginine and the risk of preeclampsia: a meta-analysis based on 1338 participants.

PubMed

Yuan, Jing; Wang, Xinguo; Xie, Yudou; Wang, Yuzhi; Dong, Lei; Li, Hong; Zhu, Tongyu

2017-07-04

Patients with preeclampsia have higher circulating asymmetric dimethylarginine (ADMA). However, whether circulating ADMA is elevated before the diagnosis of preeclampsia has not been determined. A meta-analysis of observational studies that reported circulating ADMA level before the onset of preeclampsia was performed. Pubmed and Embase were searched. Standardized mean differences (SMD) with 95% confidence intervals (CI) were used to estimate the differences in circulating ADMA. A random effect model or a fixed effect model was applied depending on the heterogeneity. The predictive efficacy of circulating ADMA for the incidence of preeclampsia was also explored. Eleven comparisons with 1338 pregnant women were included. The pooled results showed that the circulating ADMA was significantly higher in women who subsequently developed preeclampsia as compared with those did not (SMD: 0.71, p < 0.001) with a moderate heterogeneity (I2 = 43%). Stratified analyses suggested elevation of circulating ADMA is more remarkable in studies with GA of ADMA sampling ≥ 20 weeks (SMD: 0.89, p < 0.01) as compared those with GA of ADMA sampling < 20 weeks (SMD: 0.56, p < 0.01; p for subgroup interaction = 0.03). Differences of maternal age, study design, and ADMA measurement methods did not significantly affect the results. Only two studies evaluated the potential predicting ability of circulating ADMA for subsequent preeclampsia, and retrieved moderate predictive efficacy. Circulating ADMA is elevated before the development of preeclampsia. Studies are needed to evaluate the predictive efficacy of ADMA for the incidence of preeclampsia.

3D Visualization of Global Ocean Circulation

NASA Astrophysics Data System (ADS)

Nelson, V. G.; Sharma, R.; Zhang, E.; Schmittner, A.; Jenny, B.

2015-12-01

Advanced 3D visualization techniques are seldom used to explore the dynamic behavior of ocean circulation. Streamlines are an effective method for visualization of flow, and they can be designed to clearly show the dynamic behavior of a fluidic system. We employ vector field editing and extraction software to examine the topology of velocity vector fields generated by a 3D global circulation model coupled to a one-layer atmosphere model simulating preindustrial and last glacial maximum (LGM) conditions. This results in a streamline-based visualization along multiple density isosurfaces on which we visualize points of vertical exchange and the distribution of properties such as temperature and biogeochemical tracers. Previous work involving this model examined the change in the energetics driving overturning circulation and mixing between simulations of LGM and preindustrial conditions. This visualization elucidates the relationship between locations of vertical exchange and mixing, as well as demonstrates the effects of circulation and mixing on the distribution of tracers such as carbon isotopes.

Large-Scale Transport Responses to Tropospheric Circulation Changes Using GEOS-5

NASA Technical Reports Server (NTRS)

Orbe, Clara; Molod, Andrea; Arnold, Nathan; Waugh, Darryn W.; Yang, Huang

2017-01-01

The mean age since air was last at the Northern Hemisphere midlatitude surface is a fundamental property of tropospheric transport. Recent comparisons among chemistry climate models, however, reveal that there are large differences in the mean age among models and that these differences are most likely related to differences in tropical (parameterized) convection. Here we use aquaplanet simulations of the Goddard Earth Observing System Model Version 5 (GEOS-5) to explore the sensitivity of the mean age to changes in the tropical circulation. Tropical circulation changes are forced by prescribed localized off-equatorial warm sea surface temperature anomalies that (qualitatively) reproduce the convection and circulation differences among the comprehensive models. Idealized chemical species subject to prescribed OH loss are also integrated in parallel in order to illustrate the impact of tropical transport changes on interhemispheric constituent transport.

Seasonal Water Transport in the Atmosphere of Mars: Applications of a Mars General Circulation Model Using Mars Global Surveyor Data

NASA Technical Reports Server (NTRS)

Hollingsworth, Jeffery L.; Bridger, Alison F. C.; Haberle, Robert M.

1999-01-01

This is a Final Report for a Joint Research Interchange (JRI) between NASA Ames Research Center and San Jose State University, Department of Meteorology. We present below a summary of progress made during the duration of this JRI. The focus of this JRI has been to investigate seasonal water vapor transport in the atmosphere of Mars and its effects on the planet's present climate. To this end, the primary task has been to adapt a new dynamical processor for the adiabatic tendencies of the atmospheric circulation into the NASA Ames Mars general circulation model (MGCM). Using identical boundary and initial conditions, several comparative tests between the new and old MGCMs have been performed and the nature of the simulated circulations have been diagnosed. With confidence that the updated version of the Ames MGCM produces quite similar mean and eddy circulation statistics, the new climate model is well poised as a tool to pursue fundamental questions related to the spatial and seasonal variations of atmospheric water vapor on Mars, and to explore exchanges of water with non-atmospheric reservoirs and transport within its atmosphere. In particular, the role of surface sources and sinks can be explored, the range of water-vapor saturation altitudes can be investigated, and plausible precipitation mechanisms can be studied, for a range of atmospheric dust loadings. Such future investigations can contribute to a comprehensive study of surface inventories, exchange mechanisms, and the relative importance of atmospheric transport Mars' water cycle. A listing of presentations made and manuscripts submitted during the course of this project is provided.

Seasonal Water Transport in the Atmosphere of Mars: Applications of a Mars General Circulation Model Using Mars Global Surveyor Data

NASA Technical Reports Server (NTRS)

Hollingsworth, Jeffery L.; Bridger, Alison F. C.; Haberle, Robert M.

1999-01-01

This is a Final Report for a Joint Research Interchange (JRI) between NASA Ames Research Center and San Jose State University, Department of Meteorology. We present below a summary of progress made during the duration of this JRI. The focus of this JRI has been to investigate seasonal water vapor transport in the atmosphere of Mars and its effects on the planet's present climate. To this end, the primary task has been to adapt a new dynamical processor for the adiabatic tendencies of the atmospheric circulation into the NASA Ames Mars general circulation model (MGCM). Using identical boundary and initial conditions, several comparative tests between the new and old MGCMs have been performed and the nature of the simulated circulations have been diagnosed. With confidence that the updated version of the Ames MGCM produces quite similar mean and eddy circulation statistics, the new climate model is well poised as a tool to pursue fundamental questions related to the spatial and seasonal variations of atmospheric water vapor on Mars, and to explore exchanges of water with non-atmospheric reservoirs and transport within its atmosphere. In particular, the role of surface sources and sinks can be explored, the range of water-vapor saturation altitudes can be investigated, and plausible precipitation mechanisms can be studied, for a range of atmospheric dust loadings, such future investigations can contribute to a comprehensive study of surface inventories, exchange mechanisms, and the relative importance of atmospheric transport Mars' water cycle. A listing of presentations made and manuscripts submitted during the course of this project is provided.

Water mass changes inferred by gravity field variations with GRACE

NASA Astrophysics Data System (ADS)

Fagiolini, Elisa; Gruber, Christian; Apel, Heiko; Viet Dung, Nguyen; Güntner, Andreas

2013-04-01

Since 2002 the Gravity Recovery And Climate Experiment (GRACE) mission has been measuring temporal variations of Earth's gravity field depicting with extreme accuracy how mass is distributed and varies around the globe. Advanced signal separation techniques enable to isolate different sources of mass such as atmospheric and oceanic circulation or land hydrology. Nowadays thanks to GRACE, floods, droughts, and water resources monitoring are possible on a global scale. At GFZ Potsdam scientists have been involved since 2000 in the initiation and launch of the GRACE precursor CHAMP satellite mission, since 2002 in the GRACE Science Data System and since 2009 in the frame of ESÁs GOCE High Processing Facility as well as projected GRACE FOLLOW-ON for the continuation of time variable gravity field determination. Recently GFZ has reprocessed the complete GRACE time-series of monthly gravity field spherical harmonic solutions with improved standards and background models. This new release (RL05) already shows significantly less noise and spurious artifacts. In order to monitor water mass re-distribution and fast moving water, we still need to reach a higher resolution in both time and space. Moreover, in view of disaster management applications we need to act with a shorter latency (current latency standard is 2 months). For this purpose, we developed a regional method based on radial base functions that is capable to compute models in regional and global representation. This new method localizes the gravity observation to the closest regions and omits spatial correlations with farther regions. Additionally, we succeeded to increase the temporal resolution to sub-monthly time scales. Innovative concepts such as Kalman filtering and regularization, along with sophisticated regional modeling have shifted temporal and spatial resolution towards new frontiers. We expect global hydrological models as WHGM to profit from such accurate outcomes. First results comparing the mass changes over the Mekong Delta observed with GRACE with spatial explicit hydraulic simulations of the large scale annual inundation volume during the flood season are presented and discussed.

Relationship between Air Pollution and Weather Conditions under Complicated Geographical conditions

NASA Astrophysics Data System (ADS)

Cheng, Q.; Jiang, P.; Li, M.

2017-12-01

Air pollution is one of the most serious issues all over the world, especially in megacities with constrained geographical conditions for air pollution diffusion. However, the dynamic mechanism of air pollution diffusion under complicated geographical conditions is still be confused. Researches to explore relationship between air pollution and weather conditions from the perspective of local atmospheric circulations can contribute more to solve such problem. We selected three megacities (Beijing, Shanghai and Guangzhou) under different geographical condition (mountain-plain transition region, coastal alluvial plain and coastal hilly terrain) to explore the relationship between air pollution and weather conditions. RDA (Redundancy analysis) model was used to analyze how the local atmospheric circulation acts on the air pollutant diffusion. The results show that there was a positive correlation between the concentration of air pollutants and air pressure, while temperature, precipitation and wind speed have negative correlations with the concentration of air pollutants. Furthermore, geographical conditions, such as topographic relief, have significant effects on the direction, path and intensity of local atmospheric circulation. As a consequence, air pollutants diffusion modes in different cities under various geographical conditions are diverse from each other.

SpaceX Dragon Air Circulation System

NASA Technical Reports Server (NTRS)

Hernandez, Brenda; Piatrovich, Siarhei; Prina, Mauro

2011-01-01

The Dragon capsule is a reusable vehicle being developed by Space Exploration Technologies (SpaceX) that will provide commercial cargo transportation to the International Space Station (ISS). Dragon is designed to be a habitable module while it is berthed to ISS. As such, the Dragon Environmental Control System (ECS) consists of pressure control and pressure equalization, air sampling, fire detection, illumination, and an air circulation system. The air circulation system prevents pockets of stagnant air in Dragon that can be hazardous to the ISS crew. In addition, through the inter-module duct, the air circulation system provides fresh air from ISS into Dragon. To utilize the maximum volume of Dragon for cargo packaging, the Dragon ECS air circulation system is designed around cargo rack optimization. At the same time, the air circulation system is designed to meet the National Aeronautics Space Administration (NASA) inter-module and intra-module ventilation requirements and acoustic requirements. A flight like configuration of the Dragon capsule including the air circulation system was recently assembled for testing to assess the design for inter-module and intra-module ventilation and acoustics. The testing included the Dragon capsule, and flight configuration in the pressure section with cargo racks, lockers, all of the air circulation components, and acoustic treatment. The air circulation test was also used to verify the Computational Fluid Dynamics (CFD) model of the Dragon capsule. The CFD model included the same Dragon internal geometry that was assembled for the test. This paper will describe the Dragon air circulation system design which has been verified by testing the system and with CFD analysis.

The potential of air-sea interactions for improving summertime North Atlantic seasonal forecasts

NASA Astrophysics Data System (ADS)

Ossó, Albert; Shaffrey, Len; Dong, Buwen; Sutton, Rowan

2017-04-01

Delivering skillful summertime seasonal forecasts of the Northern Hemisphere (NH) mid-latitude climate is a key unresolved issue for the climate science community. Current climate models have some skill in forecasting the wintertime NH mid-latitude circulation but very limited skill during summertime. To explore the potential predictability of the summertime climate we analyze lagged correlation patterns between the SSTs and summer atmospheric circulation in the North Atlantic both in observations and climate model outputs. We find observational evidence in the ERA-Interim (1979-2015) reanalysis and the HadSLP2 and HadISST data of an SST pattern forced by late winter atmospheric circulation persisting from winter to early summer that excites an anticyclonic summer SLP anomaly west of the British Isles. We show that the atmospheric response is driven through the action of turbulent heat fluxes and changes on the background baroclinicity. The lagged atmospheric response to the SSTs could be exploited for summertime predictability over Western Europe. We find a statistical significant correlation of over 0.6 between April-May North Atlantic SSTs and the June-August North Atlantic SLP anomaly. The previous findings are further explored using 120 years of coupled ocean-atmosphere HadGEM3-GC2 model simulation. The climate model qualitatively reproduces the observed spatial relationship between the late winter and spring SSTs and summertime circulation, although the correlations are substantially weaker than observed.

On the glacial and inter-glacial thermohaline circulation and the associated transports of heat and freshwater

NASA Astrophysics Data System (ADS)

Ballarotta, M.; Falahat, S.; Brodeau, L.; Döös, K.

2014-03-01

The change of the thermohaline circulation (THC) between the Last Glacial Maximum (LGM, ≈ 21 kyr ago) and the present day climate are explored using an Ocean General Circulation Model and stream functions projected in various coordinates. Compared to the present day period, the LGM circulation is reorganised in the Atlantic Ocean, in the Southern Ocean and particularly in the abyssal ocean, mainly due to the different haline stratification. Due to stronger wind stress, the LGM tropical circulation is more vigorous than under modern conditions. Consequently, the maximum tropical transport of heat is slightly larger during the LGM. In the North Atlantic basin, the large sea-ice extent during the LGM constrains the Gulf Stream to propagate in a more zonal direction, reducing the transport of heat towards high latitudes and reorganising the freshwater transport. The LGM circulation is represented as a large intrusion of saline Antarctic Bottom Water into the Northern Hemisphere basins. As a result, the North Atlantic Deep Water is shallower in the LGM simulation. The stream functions in latitude-salinity coordinates and thermohaline coordinates point out the different haline regimes between the glacial and interglacial period, as well as a LGM Conveyor Belt circulation largely driven by enhanced salinity contrast between the Atlantic and the Pacific basin. The thermohaline structure in the LGM simulation is the result of an abyssal circulation that lifts and deviates the Conveyor Belt cell from the area of maximum volumetric distribution, resulting in a ventilated upper layer above a deep stagnant layer, and an Atlantic circulation more isolated from the Pacific. An estimation of the turnover times reveal a deep circulation almost sluggish during the LGM, and a Conveyor Belt cell more vigorous due to the combination of stronger wind stress and shortened circulation route.

Crustal architecture and tectonic evolution in the South Pole frontier, East Antarctica, in light of recent aerogeophysical observations

NASA Astrophysics Data System (ADS)

Ferraccioli, Fausto; Jordan, Tom; Forsberg, Rene; Olesen, Arne; Eagles, Graeme; Matsuoka, Kenichi; Casal, Tania

2017-04-01

Our knowledge of interior East Antarctica has increased significantly in recent years, aided by major aerogeophysical exploration efforts conducted by the geosciences community since the International Polar Year. Aerogeophysical and satellite imaging is helping unveil cryptic crustal provinces and this is enabling new studies of the major tectonic process that shaped East Antarctica through the supercontinent cycle (e.g. Ferraccioli et al., 2011, Nature; Aitken et al., 2014, GRL). However, the South Pole itself has remained one of the largest "poles of ignorance", as very little data have been acquired here since pioneering aerogeophysical surveys performed in the 1970's and a single more detailed US survey flown in the late 1990's from the Transantarctic Mountains to South Pole (Studinger et al., 2006, EPSL). During the 2015-2016 Antarctic campaign we flew a major aerogeophysical survey over the South Pole frontier, collecting ca 30,000 line km of new radio echo sounding, laser altimetry, airborne gravity and aeromagnetic data. The main aim of the PolarGAP project, supported by the European Space Agency was to fill in the data void in GOCE (Gravity Field and Steady-State Ocean Circulation Explorer) satellite gravity south of 83.3°S. Here we present the new ice thickness, bedrock topography, and gravity and magnetic anomaly images derived from the survey and interpret them to investigate the crustal architecture and tectonic evolution of the South Pole region. The Free-air gravity and radar data reveal the form and extent of the Pensacola-Pole Subglacial Basin that stretches from the Weddell Sea to South Pole. Linear free-air gravity lows within the basin are interpreted here as a system of glacially overdeepened grabens flanked by uplifted horst blocks, including the Pensacola Mountains, Patuxent Range and the Argentine Range. The grabens are inferred to be linked to the Jurassic Transantarctic rift system, which at regional to continental-scale, is associated with voluminous tholeiitic magmatism of the Ferrar Large Igneous province. Whether these grabens were reactivated in post-Jurassic times in response to intraplate stresses following Gondwana breakup, such as proposed in some sectors of the Transantarctic Mountains (e.g. Ferraccioli and Bozzo, 2003 Geol. Soc. London) or the Shackleton Range (e.g. Paxman et al., 2017 JGR in review) remains to be more fully evaluated. To investigate the potential influence of basement provinces and their tectonic boundaries on the Pensacola-Pole basin, we combined the new PolarGAP aeromagnetic data with recent aeromagnetic data acquired over the Recovery Glacier region and also examined satellite magnetic (MF7) patterns. Our new compilation reveals that part of the eastern flank of the basin is controlled by a major inherited crustal boundary, interpreted here as the southern edge of a hitherto unrecognised composite Precambrian microplate, extending from the Shackleton Range to the Pensacola-Pole basin. We further hypothesise that this inferred microplate is a key "missing link" between the southern end of the subduction-related Ross Orogen and the inferred Pan-African age collisional suture and transpressional shear zones of the Shackleton Range region.

Cold Atom Interferometers Used In Space (CAIUS) for Measuring the Earth's Gravity Field

NASA Astrophysics Data System (ADS)

Carraz, O.; Luca, M.; Siemes, C.; Haagmans, R.; Silvestrin, P.

2016-12-01

In the past decades, it has been shown that atomic quantum sensors are a newly emerging technology that can be used for measuring the Earth's gravity field. There are two ways of making use of that technology: One is a gravity gradiometer concept and the other is in a low-low satellite-to-satellite ranging concept. Whereas classical accelerometers typically suffer from high noise at low frequencies, Cold Atom Interferometers are highly accurate over the entire frequency range. We recently proposed a concept using cold atom interferometers for measuring all diagonal elements of the gravity gradient tensor and the full spacecraft angular velocity in order to achieve better performance than the GOCE gradiometer over a larger part of the spectrum, with the ultimate goals of determining the fine structures in the gravity field better than today. This concept relies on a high common mode rejection, which relaxes the drag free control compare to GOCE mission, and benefits from a long interaction time with the free falling clouds of atoms due to the micro gravity environment in space as opposed to the 1-g environment on-ground. Other concept is also being studied in the frame of NGGM, which relies on the hybridization between quantum and classical techniques to improve the performance of accelerometers. This could be achieved as it is realized in frequency measurements where quartz oscillators are phase locked on atomic or optical clocks. This technique could correct the spectrally colored noise of the electrostatic accelerometers in the lower frequencies. In both cases, estimation of the Earth gravity field model from the instruments has to be evaluated taking into account different system parameters such as attitude control, altitude of the satellite, time duration of the mission, etc. Miniaturization, lower consumptions and upgrading Technical Readiness Level are the key engineering challenges that have to be faced for these space quantum technologie.

Assessments on GOCE-based Gravity Field Model Comparisons with Terrestrial Data Using Wavelet Decomposition and Spectral Enhancement Approaches

NASA Astrophysics Data System (ADS)

Erol, Serdar; Serkan Isık, Mustafa; Erol, Bihter

2016-04-01

The recent Earth gravity field satellite missions data lead significant improvement in Global Geopotential Models in terms of both accuracy and resolution. However the improvement in accuracy is not the same everywhere in the Earth and therefore quantifying the level of improvement locally is necessary using the independent data. The validations of the level-3 products from the gravity field satellite missions, independently from the estimation procedures of these products, are possible using various arbitrary data sets, as such the terrestrial gravity observations, astrogeodetic vertical deflections, GPS/leveling data, the stationary sea surface topography. Quantifying the quality of the gravity field functionals via recent products has significant importance for determination of the regional geoid modeling, base on the satellite and terrestrial data fusion with an optimal algorithm, beside the statistical reporting the improvement rates depending on spatial location. In the validations, the errors and the systematic differences between the data and varying spectral content of the compared signals should be considered in order to have comparable results. In this manner this study compares the performance of Wavelet decomposition and spectral enhancement techniques in validation of the GOCE/GRACE based Earth gravity field models using GPS/leveling and terrestrial gravity data in Turkey. The terrestrial validation data are filtered using Wavelet decomposition technique and the numerical results from varying levels of decomposition are compared with the results which are derived using the spectral enhancement approach with contribution of an ultra-high resolution Earth gravity field model. The tests include the GO-DIR-R5, GO-TIM-R5, GOCO05S, EIGEN-6C4 and EGM2008 global models. The conclusion discuss the superiority and drawbacks of both concepts as well as reporting the performance of tested gravity field models with an estimate of their contribution to modeling the geoid in Turkish territory.

Fast Adjustments of the Asian Summer Monsoon to Anthropogenic Aerosols

NASA Astrophysics Data System (ADS)

Li, Xiaoqiong; Ting, Mingfang; Lee, Dong Eun

2018-01-01

Anthropogenic aerosols are a major factor contributing to human-induced climate change, particularly over the densely populated Asian monsoon region. Understanding the physical processes controlling the aerosol-induced changes in monsoon rainfall is essential for reducing the uncertainties in the future projections of the hydrological cycle. Here we use multiple coupled and atmospheric general circulation models to explore the physical mechanisms for the aerosol-driven monsoon changes on different time scales. We show that anthropogenic aerosols induce an overall reduction in monsoon rainfall and circulation, which can be largely explained by the fast adjustments over land north of 20∘N. This fast response occurs before changes in sea surface temperature (SST), largely driven by aerosol-cloud interactions. However, aerosol-induced SST feedbacks (slow response) cause substantial changes in the monsoon meridional circulation over the oceanic regions. Both the land-ocean asymmetry and meridional temperature gradient are key factors in determining the overall monsoon circulation response.

Point-of-care diagnostic tools to detect circulating microRNAS as biomarkers of disease.

PubMed

Vaca, Luis

2014-05-22

MicroRNAs or miRNAs are a form of small non-coding RNAs (ncRNAs) of 19-22 nucleotides in length in their mature form. miRNAs are transcribed in the nucleus of all cells from large precursors, many of which have several kilobases in length. Originally identified as intracellular modulators of protein synthesis via posttranscriptional gene silencing, more recently it has been found that miRNAs can travel in extracellular human fluids inside specialized vesicles known as exosomes. We will be referring to this miRNAs as circulating microRNAs. More interestingly, the miRNA content inside exosomes changes during pathological events. In the present review we analyze the literature about circulating miRNAs and their possible use as biomarkers. Furthermore, we explore their future in point-of-care (POC) diagnostics and provide an example of a portable POC apparatus useful in the detection of circulating miRNAs.

Evaluation of Two Commercial Enzyme-Linked Immunosorbent Assay Kits for the Detection of Human Circulating Metrnl.

PubMed

Zheng, Si-Li; Li, Zhi-Yong; Zhang, Zheng; Wang, Dong-Sheng; Xu, Jian; Miao, Chao-Yu

2018-04-01

Metrnl is a newly discovered secreted protein with neurotrophic activity and metabolic effect, while in earlier studies its circulating level in human was not explored. We evaluated two commercial enzyme-linked immunosorbent assay kits (DY7867-05, R&D Systems and SK00478-02, Aviscera Bioscience) for the detection of human circulating Metrnl. The DY7867-05 kit showed superiority over the SK00478-02 kit since it generated better curve fitting degree, smaller variation among tests, higher inter-assay reproducibility and better specificity, and could effectively detect human Metrnl in six types of blood samples. Subsequent analysis was performed using the DY7867-05 kit. Sample storage conditions were investigated. No gender difference in circulating Metrnl levels was found, while people with newly diagnosed type 2 diabetes mellitus (T2DM) had significantly lower Metrnl levels compared to the healthy controls.

Liquid biopsy: a step forward towards precision medicine in urologic malignancies.

PubMed

Di Meo, Ashley; Bartlett, Jenni; Cheng, Yufeng; Pasic, Maria D; Yousef, George M

2017-04-14

There is a growing trend towards exploring the use of a minimally invasive "liquid biopsy" to identify biomarkers in a number of cancers, including urologic malignancies. Multiple aspects can be assessed in circulating cell-free DNA, including cell-free DNA levels, integrity, methylation and mutations. Other prospective liquid biopsy markers include circulating tumor cells, circulating RNAs (miRNA, lncRNAs and mRNAs), cell-free proteins, peptides and exosomes have also emerged as non-invasive cancer biomarkers. These circulating molecules can be detected in various biological fluids, including blood, urine, saliva and seminal plasma. Liquid biopsies hold great promise for personalized medicine due to their ability to provide multiple non-invasive global snapshots of the primary and metastatic tumors. Molecular profiling of circulating molecules has been a stepping-stone to the successful introduction of several non-invasive multi-marker tests into the clinic. In this review, we provide an overview of the current state of cell-free DNA-based kidney, prostate and bladder cancer biomarker research and discuss the potential utility other circulating molecules. We will also discuss the challenges and limitations facing non-invasive cancer biomarker discovery and the benefits of this growing area of translational research.

A refined model of sedimentary rock cover in the southeastern part of the Congo basin from GOCE gravity and vertical gravity gradient observations

NASA Astrophysics Data System (ADS)

Martinec, Zdeněk; Fullea, Javier

2015-03-01

We aim to interpret the vertical gravity and vertical gravity gradient of the GOCE-GRACE combined gravity model over the southeastern part of the Congo basin to refine the published model of sedimentary rock cover. We use the GOCO03S gravity model and evaluate its spherical harmonic representation at or near the Earth's surface. In this case, the gradiometry signals are enhanced as compared to the original measured GOCE gradients at satellite height and better emphasize the spatial pattern of sedimentary geology. To avoid aliasing, the omission error of the modelled gravity induced by the sedimentary rocks is adjusted to that of the GOCO03S gravity model. The mass-density Green's functions derived for the a priori structure of the sediments show a slightly greater sensitivity to the GOCO03S vertical gravity gradient than to the vertical gravity. Hence, the refinement of the sedimentary model is carried out for the vertical gravity gradient over the basin, such that a few anomalous values of the GOCO03S-derived vertical gravity gradient are adjusted by refining the model. We apply the 5-parameter Helmert's transformation, defined by 2 translations, 1 rotation and 2 scale parameters that are searched for by the steepest descent method. The refined sedimentary model is only slightly changed with respect to the original map, but it significantly improves the fit of the vertical gravity and vertical gravity gradient over the basin. However, there are still spatial features in the gravity and gradiometric data that remain unfitted by the refined model. These may be due to lateral density variation that is not contained in the model, a density contrast at the Moho discontinuity, lithospheric density stratifications or mantle convection. In a second step, the refined sedimentary model is used to find the vertical density stratification of sedimentary rocks. Although the gravity data can be interpreted by a constant sedimentary density, such a model does not correspond to the gravitational compaction of sedimentary rocks. Therefore, the density model is extended by including a linear increase in density with depth. Subsequent L2 and L∞ norm minimization procedures are applied to find the density parameters by adjusting both the vertical gravity and the vertical gravity gradient. We found that including the vertical gravity gradient in the interpretation of the GOCO03S-derived data reduces the non-uniqueness of the inverse gradiometric problem for density determination. The density structure of the sedimentary formations that provide the optimum predictions of the GOCO03S-derived gravity and vertical gradient of gravity consists of a surface density contrast with respect to surrounding rocks of 0.24-0.28 g/cm3 and its decrease with depth of 0.05-0.25 g/cm3 per 10 km. Moreover, the case where the sedimentary rocks are gravitationally completely compacted in the deepest parts of the basin is supported by L∞ norm minimization. However, this minimization also allows a remaining density contrast at the deepest parts of the sedimentary basin of about 0.1 g/cm3.

Lower Circulating B12 Is Associated with Higher Obesity and Insulin Resistance during Pregnancy in a Non-Diabetic White British Population.

PubMed

Knight, Bridget Ann; Shields, Beverley M; Brook, Adam; Hill, Anita; Bhat, Dattatray S; Hattersley, Andrew T; Yajnik, Chittaranjan S

2015-01-01

Vitamin B12 and folate are critical micronutrients needed to support the increased metabolic demands of pregnancy. Recent studies from India have suggested that low vitamin B12 and folate concentrations in pregnancy are associated with increased obesity; however differences in diet, antenatal vitamin supplementation, and socioeconomic status may limit the generalisability of these findings. We aimed to explore the cross-sectional relationship of circulating serum vitamin B12 and folate at 28 weeks' gestation with maternal adiposity and related biochemical markers in a white non diabetic UK obstetric cohort. Anthropometry and biochemistry data was available on 995 women recruited at 28 weeks gestation to the Exeter Family Study of Childhood Health. Associations between B12 and folate with maternal BMI and other obesity-related biochemical factors (HOMA-R, fasting glucose, triglycerides, HDL and AST) were explored using regression analysis, adjusting for potential confounders (socioeconomic status, vegetarian diet, vitamin supplementation, parity, haemodilution (haematocrit)). Higher 28 week BMI was associated with lower circulating vitamin B12 (r = -0.25; P<0.001) and folate (r = -0.15; P<0.001). In multiple regression analysis higher 28 week BMI remained an independent predictor of lower circulating B12 (β (95% CI) = -0.59 (-0.74, -0.44) i.e. for every 1% increase in BMI there was a 0.6% decrease in circulating B12). Other markers of adiposity/body fat metabolism (HOMA-R, triglycerides and AST) were also independently associated with circulating B12. In a similar multiple regression AST was the only independent obesity-related marker associated with serum folate (β (95% CI) = 0.16 (0.21, 0.51)). In conclusion, our study has replicated the previous Indian findings of associations between lower serum B12 and higher obesity and insulin resistance during pregnancy in a non-diabetic White British population. These findings may have important implications for fetal and maternal health in obese pregnancies.

Results of various studies made with the NCAR Thermospheric General Circulation Model (TGCM) (invited review)

NASA Technical Reports Server (NTRS)

Roble, R. G.

1986-01-01

The NCAR thermospheric general circulation model (TGCM) has been used for a variety of thermospheric dynamic studies. It has also been used to compare model predictions with measurements made from various ground-based Fabry-Perot interferometer stations, incoherent scatter radar stations and the Dynamics Explorer satellites. The various input and output features of the model are described. These include the specification of solar EUV fluxes, and descriptions of empirical models to specify auroral particle precipitation, ion drag, and magnetospheric convection. Results are presented for solstice conditions giving the model perturbation temperature and circulation response to solar heating forcing alone and also with the inclusion of magnetospheric convections for two different dawn-dusk potential drops, 20 and 60 kV respectively. Results at two constant pressure levels Z =+1 at 300 km and Z= -4 at 120 km are presented for both the winter and summer polar cap regions. The circulation over the Northern Hemisphere polar cap in both the upper and lower thermosphere are presented along with a figure showing that the circulation is mainly a non-divergent irrotational flow responding to ion drag. The results of a study made on the Southern Hemisphere polar cap during October 1981 where Dynamics Explorer satellite measurements of winds, temperature and composition are compared to TGCM predictions are also presented. A diagnostic package that has been developed to analyze the balance of forces operating in the TGCM is presented next illustrating that in the F-region ion drag and pressure provide the main force balance and in the E-region ion drag, pressure and the coriolis forces provide the main balance. The TGCM prediction for the June 10, 1983 total solar eclipse are next presented showing a thermospheric disturbance following the path of totality. Finally, results are presented giving the global circulation, temperature and composition structure of the thermosphere for solar minimum conditions at equinox with 60 kV magnetospheric convection forcing at high latitudes.

Land surface hydrology parameterization for atmospheric general circulation models including subgrid scale spatial variability

NASA Technical Reports Server (NTRS)

Entekhabi, D.; Eagleson, P. S.

1989-01-01

Parameterizations are developed for the representation of subgrid hydrologic processes in atmospheric general circulation models. Reasonable a priori probability density functions of the spatial variability of soil moisture and of precipitation are introduced. These are used in conjunction with the deterministic equations describing basic soil moisture physics to derive expressions for the hydrologic processes that include subgrid scale variation in parameters. The major model sensitivities to soil type and to climatic forcing are explored.

Physical oceanography of the US Atlantic and eastern Gulf of Mexico. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Milliman, J.D.; Imamura, E.

The report provides a summary of the physical oceanography of the U.S. Atlantic and Eastern Gulf of Mexico and its implication to offshore oil and gas exploration and development. Topics covered in the report include: meteorology and air-sea interactions, circulation on the continental shelf, continental slope and rise circulation, Gulf Stream, Loop Current, deep-western boundary current, surface gravity-wave climatology, offshore engineering implications, implications for resource commercialization, and numerical models of pollutant dispersion.

Flood events across the North Atlantic region - past development and future perspectives

NASA Astrophysics Data System (ADS)

Matti, Bettina; Dieppois, Bastien; Lawler, Damian; Dahlke, Helen E.; Lyon, Steve W.

2016-04-01

Flood events have a large impact on humans, both socially and economically. An increase in winter and spring flooding across much of northern Europe in recent years opened up the question of changing underlying hydro-climatic drivers of flood events. Predicting the manifestation of such changes is difficult due to the natural variability and fluctuations in northern hydrological systems caused by large-scale atmospheric circulations, especially under altered climate conditions. Improving knowledge on the complexity of these hydrological systems and their interactions with climate is essential to be able to determine drivers of flood events and to predict changes in these drivers under altered climate conditions. This is particularly true for the North Atlantic region where both physical catchment properties and large-scale atmospheric circulations have a profound influence on floods. This study explores changes in streamflow across North Atlantic region catchments. An emphasis is placed on high-flow events, namely the timing and magnitude of past flood events, and selected flood percentiles were tested for stationarity by applying a flood frequency analysis. The issue of non-stationarity of flood return periods is important when linking streamflow to large-scale atmospheric circulations. Natural fluctuations in these circulations are found to have a strong influence on the outcome causing natural variability in streamflow records. Long time series and a multi-temporal approach allows for determining drivers of floods and linking streamflow to large-scale atmospheric circulations. Exploring changes in selected hydrological signatures consistency was found across much of the North Atlantic region suggesting a shift in flow regime. The lack of an overall regional pattern suggests that how catchments respond to changes in climatic drivers is strongly influenced by their physical characteristics. A better understanding of hydrological response to climate drivers is essential for example for forecasting purposes.

Role of changed Indo-Pacific atmospheric circulation in the recent disconnect between the Indian summer monsoon and ENSO

NASA Astrophysics Data System (ADS)

Feba, F.; Ashok, K.; Ravichandran, M.

2018-04-01

We explore the decadal variability of teleconnection from tropical Pacific to the Indian summer monsoon rainfall (ISMR) using various observational and Reanalysis datasets for the period 1958-2008. In confirmation with the earlier findings, we find that the interannual correlations between the various SST indices of ENSO and ISMR have continued to weaken. Interestingly, we find that even the robust lead correlations of the tropical pacific warm-water-volume with ISMR have weakened since late 1970s. Our analysis suggests that there is a relative intensification of the cross-equatorial flow from the southern hemisphere into the equatorial Indian Ocean associated with ISMR due to strenghtening of Mascarene High. Further, a shift in the surface wind circulation associated with monsoon over the northern pacific since late 1970s has resulted in a strenghtened cyclonic seasonal circulation south-east of Japan. These changed circulation features are a shift from the known circulation-signatures that efficiently teleconnect El Niño forcing to South Asia. These recent changes effectively weakened the teleconnection of the El Niño to ISMR.

Circulating DNA and its methylation level in inflammatory bowel disease and related colon cancer.

PubMed

Bai, Xuming; Zhu, Yaqun; Pu, Wangyang; Xiao, Li; Li, Kai; Xing, Chungen; Jin, Yong

2015-01-01

Both of chronic inflammation and abnormal immune in inflammatory bowel disease can induce colon cancer. Previous research showed that cell apoptosis and necrosis become the main source of circulating DNA in the peripheral blood during tumorigenesis that reduced along with methylation degree. However, its role in the process of colitis transforming to colon cancer is not clarified. Drinking 3% DSS was used to establish colitis model, while 3% dextran sodium sulfate (DSS) combined with azo oxidation methane (AOM) intraperitoneal injection was applied to establish colitis related colon cancer model. Circulating DNA and its methylation level in peripheral blood were tested. Morphology observation, HE staining, and p53 and β-catenin expression detection confirmed that drinking 3% DSS and 3% DSS combined with AOM intraperitoneal injection can successfully establish colitis and colitis associated colorectal cancer models. Circulating DNA level in colitis and colon cancer mice increased by gradient compared with control, while significant difference was observed between each other. Circulating DNA methylation level decreased obviously in colitis and colon cancer, and significant difference was observed between each other. Abnormal protein expression, circulating DNA and its methylation level in ulcerative colitis associated colorectal tissues change in gradient, suggesting that circulating DNA and its methylation level can be treated as new markers for colitis cancer transformation that has certain significance to explore the mechanism of human ulcerative colitis canceration.

On the glacial and interglacial thermohaline circulation and the associated transports of heat and freshwater

NASA Astrophysics Data System (ADS)

Ballarotta, M.; Falahat, S.; Brodeau, L.; Döös, K.

2014-11-01

The thermohaline circulation (THC) and the oceanic heat and freshwater transports are essential for understanding the global climate system. Streamfunctions are widely used in oceanography to represent the THC and estimate the transport of heat and freshwater. In the present study, the regional and global changes of the THC, the transports of heat and freshwater and the timescale of the circulation between the Last Glacial Maximum (LGM, ≈ 21 kyr ago) and the present-day climate are explored using an Ocean General Circulation Model and streamfunctions projected in various coordinate systems. We found that the LGM tropical circulation is about 10% stronger than under modern conditions due to stronger wind stress. Consequently, the maximum tropical transport of heat is about 20% larger during the LGM. In the North Atlantic basin, the large sea-ice extent during the LGM constrains the Gulf Stream to propagate in a more zonal direction, reducing the transport of heat towards high latitudes by almost 50% and reorganising the freshwater transport. The strength of the Atlantic Meridional Overturning Circulation depends strongly on the coordinate system. It varies between 9 and 16 Sv during the LGM, and between 12 to 19 Sv for the present day. Similar to paleo-proxy reconstructions, a large intrusion of saline Antarctic Bottom Water takes place into the Northern Hemisphere basins and squeezes most of the Conveyor Belt circulation into a shallower part of the ocean. These different haline regimes between the glacial and interglacial period are illustrated by the streamfunctions in latitude-salinity coordinates and thermohaline coordinates. From these diagnostics, we found that the LGM Conveyor Belt circulation is driven by an enhanced salinity contrast between the Atlantic and the Pacific basin. The LGM abyssal circulation lifts and makes the Conveyor Belt cell deviate from the abyssal region, resulting in a ventilated upper layer above a deep stagnant layer, and an Atlantic circulation more isolated from the Pacific. An estimate of the timescale of the circulation reveals a sluggish abyssal circulation during the LGM, and a Conveyor Belt circulation that is more vigorous due to the combination of a stronger wind stress and a shortened circulation route.

Does coupled ocean enhance ozone-hole-induced Southern Hemisphere circulation changes?

NASA Astrophysics Data System (ADS)

Son, S. W.; Han, B. R.; Kim, S. Y.; Park, R.

2017-12-01

The ozone-hole-induced Southern Hemisphere (SH) circulation changes, such as poleward shift of westerly jet and Hadley cell widening, have been typically explored with either coupled general circulation models (CGCMs) prescribing stratospheric ozone or chemistry-climate models (CCMs) prescribing surface boundary conditions. Only few studies have utilized ocean-coupled CCMs with a relatively coarse resolution. To better quantify the role of interactive chemistry and coupled ocean in the ozone-hole-induced SH circulation changes, the present study examines a set of CGCM and CCM simulations archived for the Coupled Model Intercomparison Project phase 5 (CMIP5) and CCM initiative (CCMI). Although inter-model spread of Antarctic ozone depletion is substantially large especially in the austral spring, both CGCMs with relatively simple ozone chemistry and CCMs with fully interactive comprehensive chemistry reasonably well reproduce long-term trends of Antarctic ozone and the associated polar-stratospheric temperature changes. Most models reproduce a poleward shift of SH jet and Hadley-cell widening in the austral summer in the late 20th century as identified in reanalysis datasets. These changes are quasi-linearly related with Antarctic ozone changes, confirming the critical role of Antarctic ozone depletion in the austral-summer zonal-mean circulation changes. The CGCMs with simple but still interactive ozone show slightly stronger circulation changes than those with prescribed ozone. However, the long-term circulation changes in CCMs are largely insensitive to the coupled ocean. While a few models show the enhanced circulation changes when ocean is coupled, others show essentially no changes or even weakened circulation changes. This result suggests that the ozone-hole-related stratosphere-troposphere coupling in the late 20th century may be only weakly sensitive to the coupled ocean.

Enhanced anti-tumour immunity requires the interplay between resident and circulating memory CD8+ T cells

PubMed Central

Enamorado, Michel; Iborra, Salvador; Priego, Elena; Cueto, Francisco J.; Quintana, Juan A.; Martínez-Cano, Sarai; Mejías-Pérez, Ernesto; Esteban, Mariano; Melero, Ignacio; Hidalgo, Andrés; Sancho, David

2017-01-01

The goal of successful anti-tumoural immunity is the development of long-term protective immunity to prevent relapse. Infiltration of tumours with CD8+ T cells with a resident memory (Trm) phenotype correlates with improved survival. However, the interplay of circulating CD8+ T cells and Trm cells remains poorly explored in tumour immunity. Using different vaccination strategies that fine-tune the generation of Trm cells or circulating memory T cells, here we show that, while both subsets are sufficient for anti-tumour immunity, the presence of Trm cells improves anti-tumour efficacy. Transferred central memory T cells (Tcm) generate Trm cells following viral infection or tumour challenge. Anti-PD-1 treatment promotes infiltration of transferred Tcm cells within tumours, improving anti-tumour immunity. Moreover, Batf3-dependent dendritic cells are essential for reactivation of circulating memory anti-tumour response. Our findings show the plasticity, collaboration and requirements for reactivation of memory CD8+ T cells subsets needed for optimal tumour vaccination and immunotherapy. PMID:28714465

Regional climates in the GISS general circulation model: Surface air temperature

NASA Technical Reports Server (NTRS)

Hewitson, Bruce

1994-01-01

One of the more viable research techniques into global climate change for the purpose of understanding the consequent environmental impacts is based on the use of general circulation models (GCMs). However, GCMs are currently unable to reliably predict the regional climate change resulting from global warming, and it is at the regional scale that predictions are required for understanding human and environmental responses. Regional climates in the extratropics are in large part governed by the synoptic-scale circulation and the feasibility of using this interscale relationship is explored to provide a way of moving to grid cell and sub-grid cell scales in the model. The relationships between the daily circulation systems and surface air temperature for points across the continental United States are first developed in a quantitative form using a multivariate index based on principal components analysis (PCA) of the surface circulation. These relationships are then validated by predicting daily temperature using observed circulation and comparing the predicted values with the observed temperatures. The relationships predict surface temperature accurately over the major portion of the country in winter, and for half the country in summer. These relationships are then applied to the surface synoptic circulation of the Goddard Institute for Space Studies (GISS) GCM control run, and a set of surface grid cell temperatures are generated. These temperatures, based on the larger-scale validated circulation, may now be used with greater confidence at the regional scale. The generated temperatures are compared to those of the model and show that the model has regional errors of up to 10 C in individual grid cells.

Planets of the solar system. [Jupiter and Venus

NASA Technical Reports Server (NTRS)

Kondratyev, K. Y.; Moskalenko, N. I.

1978-01-01

Venera and Mariner spacecraft and ground based radio astronomy and spectroscopic observations of the atmosphere and surface of venus are examined. The composition and structural parameters of the atmosphere are discussed as the basis for development of models and theories of the vertical structure of the atmosphere, the greenhouse effect, atmospheric circulation and cloud cover. Recommendations for further meteorological studies are given. Ground based and Pioneer satellite observation data on Jupiter are explored as well as calculations and models of the cloud structure, atmospheric circulation and thermal emission field of Jupiter.

"What Controls the Structure and Stability of the Ocean Meridional Overturning Circulation: Implications for Abrupt Climate Change?"

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fedorov, Alexey

2013-11-23

The central goal of this research project is to understand the properties of the ocean meridional overturning circulation (MOC) – a topic critical for understanding climate variability and stability on a variety of timescales (from decadal to centennial and longer). Specifically, we have explored various factors that control the MOC stability and decadal variability in the Atlantic and the ocean thermal structure in general, including the possibility abrupt climate change. We have also continued efforts on improving the performance of coupled ocean-atmosphere GCMs.

The prehistory of biology preprints: A forgotten experiment from the 1960s.

PubMed

Cobb, Matthew

2017-11-01

In 1961, the National Institutes of Health (NIH) began to circulate biological preprints in a forgotten experiment called the Information Exchange Groups (IEGs). This system eventually attracted over 3,600 participants and saw the production of over 2,500 different documents, but by 1967, it was effectively shut down following the refusal of journals to accept articles that had been circulated as preprints. This article charts the rise and fall of the IEGs and explores the parallels with the 1990s and the biomedical preprint movement of today.

Seasonal circulation over the Catalan inner-shelf (northwest Mediterranean Sea)

USGS Publications Warehouse

Grifoll, Manel; Aretxabaleta, Alfredo L.; Pelegrí, Josep L.; Espino, Manuel; Warner, John C.; Sánchez-Arcilla, Agustín

2013-01-01

This study characterizes the seasonal cycle of the Catalan inner-shelf circulation using observations and complementary numerical results. The relation between seasonal circulation and forcing mechanisms is explored through the depth-averaged momentum balance, for the period between May 2010 and April 2011, when velocity observations were partially available. The monthly-mean along-shelf flow is mainly controlled by the along-shelf pressure gradient and by surface and bottom stresses. During summer, fall, and winter, the along-shelf momentum balance is dominated by the barotropic pressure gradient and local winds. During spring, both wind stress and pressure gradient act in the same direction and are compensated by bottom stress. In the cross-shelf direction the dominant forces are in geostrophic balance, consistent with dynamic altimetry data.

Seasonal circulation over the Catalan inner-shelf (northwest Mediterranean Sea)

NASA Astrophysics Data System (ADS)

Grifoll, Manel; Aretxabaleta, Alfredo L.; Pelegrí, Josep L.; Espino, Manuel; Warner, John C.; Sánchez-Arcilla, Agustín.

2013-10-01

This study characterizes the seasonal cycle of the Catalan inner-shelf circulation using observations and complementary numerical results. The relation between seasonal circulation and forcing mechanisms is explored through the depth-averaged momentum balance, for the period between May 2010 and April 2011, when velocity observations were partially available. The monthly-mean along-shelf flow is mainly controlled by the along-shelf pressure gradient and by surface and bottom stresses. During summer, fall, and winter, the along-shelf momentum balance is dominated by the barotropic pressure gradient and local winds. During spring, both wind stress and pressure gradient act in the same direction and are compensated by bottom stress. In the cross-shelf direction the dominant forces are in geostrophic balance, consistent with dynamic altimetry data.

Lemont B. Kier: a bibliometric exploration of his scientific production and its use.

PubMed

Restrepo, Guillermo; Llanos, Eugenio J; Silva, Adriana E

2013-12-01

We thought an appropriate way to celebrate the seminal contribution of Kier is to explore his influence on science, looking for the impact of his research through the citation of his scientific production. From a bibliometric approach the impact of Kier's work is addressed as an individual within a community. Reviewing data from his curriculum vitae, as well as from the ISI Web of Knowledge (ISI), his role within the scientific community is established and the way his scientific results circulate is studied. His curriculum vitae is explored emphasising the approaches he used in his research activities and the social ties with other actors of the community. The circulation of Kier's publications in the ISI is studied as a means for spreading and installing his discourse within the community. The citation patterns found not only show the usage of Kier's scientific results, but also open the possibility to identify some characteristics of this discursive community, such as a common vocabulary and common research goals. The results show an interdisciplinary research work that consolidates a scientific community on the topic of drug discovery.

Evolution of the Power Processing Units Architecture for Electric Propulsion at CRISA

NASA Astrophysics Data System (ADS)

Palencia, J.; de la Cruz, F.; Wallace, N.

2008-09-01

Since 2002, the team formed by EADS Astrium CRISA, Astrium GmbH Friedrichshafen, and QinetiQ has participated in several flight programs where the Electric Propulsion based on Kaufman type Ion Thrusters is the baseline conceptOn 2002, CRISA won the contract for the development of the Ion Propulsion Control Unit (IPCU) for GOCE. This unit together with the T5 thruster by QinetiQ provides near perfect atmospheric drag compensation offering thrust levels in the range of 1 to 20mN.By the end of 2003, CRISA started the adaptation of the IPCU concept to the QinetiQ T6 Ion Thruster for the Alphabus program.This paper shows how the Power Processing Unit design evolved in time including the current developments.

Elevated circulating levels of succinate in human obesity are linked to specific gut microbiota.

PubMed

Serena, Carolina; Ceperuelo-Mallafré, Victoria; Keiran, Noelia; Queipo-Ortuño, Maria Isabel; Bernal, Rosa; Gomez-Huelgas, Ricardo; Urpi-Sarda, Mireia; Sabater, Mónica; Pérez-Brocal, Vicente; Andrés-Lacueva, Cristina; Moya, Andres; Tinahones, Francisco J; Fernández-Real, Jose Manuel; Vendrell, Joan; Fernández-Veledo, Sonia

2018-02-12

Gut microbiota-related metabolites are potential clinical biomarkers for cardiovascular disease (CVD). Circulating succinate, a metabolite produced by both microbiota and the host, is increased in hypertension, ischemic heart disease, and type 2 diabetes. We aimed to analyze systemic levels of succinate in obesity, a major risk factor for CVD, and its relationship with gut microbiome. We explored the association of circulating succinate with specific metagenomic signatures in cross-sectional and prospective cohorts of Caucasian Spanish subjects. Obesity was associated with elevated levels of circulating succinate concomitant with impaired glucose metabolism. This increase was associated with specific changes in gut microbiota related to succinate metabolism: a higher relative abundance of succinate-producing Prevotellaceae (P) and Veillonellaceae (V), and a lower relative abundance of succinate-consuming Odoribacteraceae (O) and Clostridaceae (C) in obese individuals, with the (P + V/O + C) ratio being a main determinant of plasma succinate. Weight loss intervention decreased (P + V/O + C) ratio coincident with the reduction in circulating succinate. In the spontaneous evolution after good dietary advice, alterations in circulating succinate levels were linked to specific metagenomic signatures associated with carbohydrate metabolism and energy production with independence of body weight change. Our data support the importance of microbe-microbe interactions for the metabolite signature of gut microbiome and uncover succinate as a potential microbiota-derived metabolite related to CVD risk.

Phase shift method to estimate solids circulation rate in circulating fluidized beds

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ludlow, James Christopher; Panday, Rupen; Shadle, Lawrence J.

2013-01-01

While solids circulation rate is a critical design and control parameter in circulating fluidized bed (CFB) reactor systems, there are no available techniques to measure it directly at conditions of industrial interest. Cold flow tests have been conducted at NETL in an industrial scale CFB unit where the solids flow has been the topic of research in order to develop an independent method which could be applied to CFBs operating under the erosive and corrosive high temperatures and pressures of a coal fired boiler or gasifier. The dynamic responses of the CFB loop to modest modulated aeration flows in themore » return leg or standpipe were imposed to establish a periodic response in the unit without causing upset in the process performance. The resulting periodic behavior could then be analyzed with a dynamic model and the average solids circulation rate could be established. This method was applied to the CFB unit operated under a wide range of operating conditions including fast fluidization, core annular flow, dilute and dense transport, and dense suspension upflow. In addition, the system was operated in both low and high total solids inventories to explore the influence of inventory limiting cases on the estimated results. The technique was able to estimate the solids circulation rate for all transport circulating fluidized beds when operating above upper transport velocity, U{sub tr2}. For CFB operating in the fast fluidized bed regime (i.e., U{sub g}< U{sub tr2}), the phase shift technique was not successful. The riser pressure drop becomes independent of the solids circulation rate and the mass flow rate out of the riser does not show modulated behavior even when the riser pressure drop does.« less

Heat flow evidence for hydrothermal circulation in the volcanic basement of subducting plates

NASA Astrophysics Data System (ADS)

Harris, R. N.; Spinelli, G. A.; Fisher, A. T.

2017-12-01

We summarize and interpret evidence for hydrothermal circulation in subducting oceanic basement from the Nankai, Costa Rica, south central Chile, Haida Gwaii, and Cascadia margins and explore the influence of hydrothermal circulation on plate boundary temperatures in these settings. Heat flow evidence for hydrothermal circulation in the volcanic basement of incoming plates includes: (a) values that are well below conductive (lithospheric) predictions due to advective heat loss, and (b) variability about conductive predictions that cannot be explained by variations in seafloor relief or thermal conductivity. We construct thermal models of these systems that include an aquifer in the upper oceanic crust that enhances heat transport via a high Nusselt number proxy for hydrothermal circulation. At the subduction zones examined, patterns of seafloor heat flow are not well fit by purely conductive simulations, and are better explained by simulations that include the influence of hydrothermal circulation. This result is consistent with the young basement ages (8-35 Ma) of the incoming igneous crust at these sites as well as results from global heat flow analyses showing a significant conductive heat flow deficit for crustal ages less than 65 Ma. Hydrothermal circulation within subducting oceanic basement can have a profound influence on temperatures close to the plate boundary and, in general, leads to plate boundary temperatures that are cooler than those where fluid flow does not occur. The magnitude of cooling depends on the permeability structure of the incoming plate and the evolution of permeability with depth and time. Resolving complex relationships between subduction processes, the permeability structure in the ocean crust, and the dynamics of hydrothermal circulation remains an interdisciplinary frontier.

A numerical study on the evolution of the wind-driven circulation in the Yellow Sea in winter

NASA Astrophysics Data System (ADS)

Tak, Y. J.; Cho, Y. K.

2016-02-01

The Yellow Sea is a semi-enclosed marginal sea and its circulation in winter is affected by the winter monsoon. In previous studies, it was found that the circulation of the Yellow Sea in winter consists of downwind and upwind currents. Downwind currents consisting of the Korean Coast Current (KCC) and the Chinese Coast Current (CCC) flow along the boundary of the Yellow Sea, whereas an upwind current consisting of the Yellow Sea Warm Current (YSWC) flows along the central trough of the Yellow Sea. Although some characteristics of such currents and the driving forces of the circulation have been studied by many scientists, the evolution of these currents has received little attention. So, the wind-driven circulation in the Yellow Sea was simulated to explain the changing pattern of these currents in winter and their evolutions were explored by the time-lagged correlation for winter season. According to the lagged correlation, downwind currents occurred in surface layer without a time lag. These downwind currents were more sensitive in the Chinese coast than that in the Korean coast. There is one day time-lag between the wind and the upwind flow developing in the Yellow Sea trough. The YSWC was shifted to the west of the trough after two days and then the KCC strengthened at the same time. It implied the westward shift of the YSWC and the clockwise circulation is developed, two days after the wind blows. The clockwise circulation was one of the reasons that the KCC was stronger than the CCC although the CCC was more sensitive to the wind than the KCC. The clockwise circulation also made the YSWC stronger in the inner YS than it at the entrance of the YS.

Ground Based Investigation of Electrostatic Accelerometer in HUST

NASA Astrophysics Data System (ADS)

Bai, Y.; Zhou, Z.

2013-12-01

High-precision electrostatic accelerometers with six degrees of freedom (DOF) acceleration measurement were successfully used in CHAMP, GRACE and GOCE missions which to measure the Earth's gravity field. In our group, space inertial sensor based on the capacitance transducer and electrostatic control technique has been investigated for test of equivalence principle (TEPO), searching non-Newtonian force in micrometer range, and satellite Earth's field recovery. The significant techniques of capacitive position sensor with the noise level at 2×10-7pF/Hz1/2 and the μV/Hz1/2 level electrostatic actuator are carried out and all the six servo loop controls by using a discrete PID algorithm are realized in a FPGA device. For testing on ground, in order to compensate one g earth's gravity, the fiber torsion pendulum facility is adopt to measure the parameters of the electrostatic controlled inertial sensor such as the resolution, and the electrostatic stiffness, the cross couple between different DOFs. A short distance and a simple double capsule equipment the valid duration about 0.5 second is set up in our lab for the free fall tests of the engineering model which can directly verify the function of six DOF control. Meanwhile, high voltage suspension method is also realized and preliminary results show that the horizontal axis of acceleration noise is about 10-8m/s2/Hz1/2 level which limited mainly by the seismic noise. Reference: [1] Fen Gao, Ze-Bing Zhou, Jun Luo, Feasibility for Testing the Equivalence Principle with Optical Readout in Space, Chin. Phys. Lett. 28(8) (2011) 080401. [2] Z. Zhu, Z. B. Zhou, L. Cai, Y. Z. Bai, J. Luo, Electrostatic gravity gradiometer design for the advanced GOCE mission, Adv. Sp. Res. 51 (2013) 2269-2276. [3] Z B Zhou, L Liu, H B Tu, Y Z Bai, J Luo, Seismic noise limit for ground-based performance measurements of an inertial sensor using a torsion balance, Class. Quantum Grav. 27 (2010) 175012. [4] H B Tu, Y Z Bai, Z B Zhou, L Liu, L Cai, and J Luo, Performance measurements of an inertial sensor with a two-stage controlled torsion pendulum, Class Quantum. Grav. 27 (2010) 205016.

Basic Radar Altimetry Toolbox: Tools to Use Radar Altimetry for Geodesy

NASA Astrophysics Data System (ADS)

Rosmorduc, V.; Benveniste, J. J.; Bronner, E.; Niejmeier, S.

2010-12-01

Radar altimetry is very much a technique expanding its applications and uses. If quite a lot of efforts have been made for oceanography users (including easy-to-use data), the use of those data for geodesy, especially combined witht ESA GOCE mission data is still somehow hard. ESA and CNES thus had the Basic Radar Altimetry Toolbox developed (as well as, on ESA side, the GOCE User Toolbox, both being linked). The Basic Radar Altimetry Toolbox is an "all-altimeter" collection of tools, tutorials and documents designed to facilitate the use of radar altimetry data. The software is able: - to read most distributed radar altimetry data, from ERS-1 & 2, Topex/Poseidon, Geosat Follow-on, Jason-1, Envisat, Jason- 2, CryoSat and the future Saral missions, - to perform some processing, data editing and statistic, - and to visualize the results. It can be used at several levels/several ways: - as a data reading tool, with APIs for C, Fortran, Matlab and IDL - as processing/extraction routines, through the on-line command mode - as an educational and a quick-look tool, with the graphical user interface As part of the Toolbox, a Radar Altimetry Tutorial gives general information about altimetry, the technique involved and its applications, as well as an overview of past, present and future missions, including information on how to access data and additional software and documentation. It also presents a series of data use cases, covering all uses of altimetry over ocean, cryosphere and land, showing the basic methods for some of the most frequent manners of using altimetry data. It is an opportunity to teach remote sensing with practical training. It has been available from April 2007, and had been demonstrated during training courses and scientific meetings. About 1200 people downloaded it (Summer 2010), with many "newcomers" to altimetry among them. Users' feedbacks, developments in altimetry, and practice, showed that new interesting features could be added. Some have been added and/or improved in version 2. Others are ongoing, some are in discussion. Examples and Data use cases on geodesy will be presented. BRAT is developed under contract with ESA and CNES.

Gravity model for the North Atlantic ocean mantle: results, uncertainties and links to regional geodynamics

NASA Astrophysics Data System (ADS)

Barantsrva, O.; Artemieva, I. M.; Thybo, H.

2015-12-01

We present the results of gravity modeling for the North Atlantic region based on interpretation of GOCE gravity satellite data. First, to separate the gravity signal caused by density anomalies within the crust and the upper mantle, we subtract the lower harmonics in the gravity field, which are presumably caused by deep density structure of the Earth (the core and the lower mantle). Next, the gravity effect of the upper mantle is calculated by subtracting the gravity effect of the crustal model. Our "basic model" is constrained by a recent regional seismic model EUNAseis for the crustal structure (Artemieva and Thybo, 2013); for bathymetry and topography we use a global ETOPO1 model by NOAA. We test sensitivity of the results to different input parameters, such as bathymetry, crustal structure, and gravity field. For bathymetry, we additionally use GEBCO data; for crustal correction - a global model CRUST 1.0 (Laske, 2013); for gravity - EGM2008 (Pavlis, 2012). Sensitivity analysis shows that uncertainty in the crustal structure produces the largest deviation from "the basic model". Use of different bathymetry data has little effect on the final results, comparable to the interpolation error. The difference in mantle residual gravity models based on GOCE and EMG2008 gravity data is 5-10 mGal. The results based on two crustal models have a similar pattern, but differ significantly in amplitude (ca. 250 mGal) for the Greenland-Faroe Ridge. The results demonstrate the presence of a strong gravity and density heterogeneity in the upper mantle in the North Atlantic region. A number of mantle residual gravity anomalies are robust features, independent of the choice of model parameters. This include (i) a sharp contrast at the continent-ocean transition, (ii) positive mantle gravity anomalies associated with continental fragments (microcontinents) in the North Atlantic ocean; (iii) negative mantle gravity anomalies which mark regions with anomalous oceanic mantle and the Mid-Atlantic Ridge. To understand better a complex geodynamics mosaic in the region, we compare our results with regional geochemical data (Korenaga and Klemen, 2000), and find that residual mantle gravity anomalies are well correlated with anomalies in epsilon-Nd and iron-depletion.

e-NIHSS: an Expanded National Institutes of Health Stroke Scale Weighted for Anterior and Posterior Circulation Strokes.

PubMed

Olivato, Silvia; Nizzoli, Silvia; Cavazzuti, Milena; Casoni, Federica; Nichelli, Paolo Frigio; Zini, Andrea

2016-12-01

The National Institutes of Health Stroke Scale (NIHSS) is the most widespread clinical scale used in patients presenting with acute stroke. The merits of the NIHSS include simplicity, quickness, and agreement between clinicians. The clinical evaluation on posterior circulation stroke remains still a limit of NIHSS. We assessed the application of a new version of NIHSS, the e-NIHSS (expanded NIHSS), adding specific elements in existing items to explore signs/symptoms of a posterior circulation stroke. A total of 22 consecutive patients with suspected vertebrobasilar stroke were compared with 25 patients with anterior circulation stroke using NIHSS and e-NIHSS. We compared the NIHSS and e-NIHSS scores obtained by the 2 examiners, in patients with posterior circulation infarct (POCI), using the Wilcoxon test. Patients with POCI evaluated with e-NIHSS had an average of 2 points higher than patients evaluated with classical NIHSS. The difference was statistically significant (P < .05), weighted by the new expanded items. The NIHSS is a practical scale model, with high reproducibility between trained, different examiners, focused on posterior circulation strokes, with the same total score and number of items of the existing NIHSS. The e-NHISS could improve the sensitivity of NIHSS in posterior circulation stroke and could have an impact on clinical trials, as well as on outcomes. Further studies are needed to investigate a larger number of patients and the correlation between the e-NIHSS score and neuroimaging findings. Copyright © 2016 National Stroke Association. Published by Elsevier Inc. All rights reserved.

Satellite gravity field derivatives for identifying geological boundaries.

NASA Astrophysics Data System (ADS)

Alvarez, O.; Gimenez, M.; Braitenberg, C.; Folguera, A.

2012-04-01

The Pampean flat slab zone developed in the last 17 Ma between 27° and 33°S, and has denuded an intricate collage of crustal blocks amalgamated during the Pampean, Famatinian and San Rafael deformational stages, that is far of being completely understood. For potential field studies these amalgamations have the effect of defining important compositional and density heterogeneities. Geophysical data from different studies show a sharp boundary between the two adjacent and contrasting crusts of Pampia and the Cuyania terrane. Recent aeromagnetic surveys have inferred a mafic and ultramafic belt interpreted as a buried ophiolitic suite hosted in the corresponding suture. This boundary coincides locally with basement exposures of high to medium grade metamorphic rocks developed in close association with the Famatinian orogen of Early to Middle Ordovician age. Lower crustal rocks are exposed along this first order crustal discontinuity. The Río de la Plata basement crops out from southern Uruguay to eastern-center Argentina with an approximate surface of 20,000 km2. Oldest rocks have been dated in 2,200 and 1,700 Ma, indicating that they constituted a different block to Pampia. The boundary between Pampia and the Rio de la Plata craton is not exposed. However, a strong gravimetric anomaly identified in the central part of the foothills of the Sierras de Córdoba indicates a first order crustal discontinuity that has been related to their collision in Neoproterozoic times. This work focuses on the determination of mass heterogeneities over the Pampean flat slab zone using gravity anomaly and vertical gravity gradient, with the aim to determine discontinuities in the pattern of terrain amalgamation that conformed the basement. Satellite gravimetry is highly sensitive to these variations. Recent satellite missions, (CHAMP, GRACE, and GOCE) have introduced an extraordinary improvement in the global mapping of the gravity field. We control the quality of the terrestrial data entering the EGM2008 by a comparison analysis with the satellite only gravitational model of GOCE up to degree N=250. Using the global model EGM2008, the vertical gravity gradient and the gravity anomaly for South Central Andes are calculated. We correct the observations for the topographic effect using tesseroids by using a 1-arc minute global relief model of earth's surface. Results are compared to a schematic geological map of the South Central Andes region, which includes main geological features with regional dimensions presumably accompanied by crustal density variations. We clearly depict the geological structures and delineation of significant terrains such as Pampia, Cuyania, and Chilenia terranes. Of great interest is the contact between the Rio de la Plata craton and the Pampia Terrain, a boundary that has not been clearly defined till now. Our work aims to highlight the potential of this new tool of satellite gravimetry, with the addition of topographic correction, to achieve tectonic interpretation of medium to long wavelength of a determined study region. We demonstrate that the new gravity fields can be used for identifying geological boundaries related to density differences, in a regional dimension and thus are a new useful tool in geophysical exploration.

Cattle temperament influences metabolism: 1. Metabolic response to a glucose tolerance test in beef steers

USDA-ARS?s Scientific Manuscript database

Temperamental cattle are behaviorally, physiologically, and immunologically different in comparison to calm cattle. Recently, the metabolic differences between temperamental and calm cattle have begun to be explored; temperamental cattle maintain greater circulating concentrations of non-esterified ...

Compaction-Driven Evolution of Pluto's Rocky Core: Implications for Water-Rock Interactions

NASA Astrophysics Data System (ADS)

Gabasova, L. R.; Tobie, G.; Choblet, G.

2018-05-01

We model the compaction of Pluto's rocky core after accretion and explore the potential for hydrothermal circulation within the porous layer, as well as examine its effect on core cooling and the persistence of a liquid internal ocean.

Circulating elastin peptides, role in vascular pathology.

PubMed

Robert, L; Labat-Robert, J

2014-12-01

The atherosclerotic process starts with the degradation of elastic fibers. Their presence was demonstrated in the circulation as well as several of their biological properties elucidated. We described years ago a procedure to obtain large elastin peptides by organo-alkaline hydrolysis, κ-elastin. This method enabled also the preparation of specific antibodies used to determine elastin peptides, as well as anti-elastin antibodies in body fluids and tissue extracts. Elastin peptides were determined in a large number of human blood samples. Studies were carried out to explore their pharmacological properties. Similar recent studies by other laboratories confirmed our findings and arose new interest in circulating elastin peptides for their biological activities. This recent trend justified the publication of a review of the biological and pathological activities of elastin peptides demonstrated during our previous studies, subject of this article. Copyright © 2014 Elsevier Masson SAS. All rights reserved.

Improved short-term variability in the thermosphere-ionosphere-mesosphere-electrodynamics general circulation model

NASA Astrophysics Data System (ADS)

Häusler, K.; Hagan, M. E.; Baumgaertner, A. J. G.; Maute, A.; Lu, G.; Doornbos, E.; Bruinsma, S.; Forbes, J. M.; Gasperini, F.

2014-08-01

We report on a new source of tidal variability in the National Center for Atmospheric Research thermosphere-ionosphere-mesosphere-electrodynamics general circulation model (TIME-GCM). Lower boundary forcing of the TIME-GCM for a simulation of November-December 2009 based on 3-hourly Modern-Era Retrospective Analysis for Research and Application (MERRA) reanalysis data includes day-to-day variations in both diurnal and semidiurnal tides of tropospheric origin. Comparison with TIME-GCM results from a heretofore standard simulation that includes climatological tropospheric tides from the global-scale wave model reveal evidence of the impacts of MERRA forcing throughout the model domain, including measurable tidal variability in the TIME-GCM upper thermosphere. Additional comparisons with measurements made by the Gravity field and steady-state Ocean Circulation Explorer satellite show improved TIME-GCM capability to capture day-to-day variations in thermospheric density for the November-December 2009 period with the new MERRA lower boundary forcing.

Influence of depression and anxiety on circulating endothelial progenitor cells in patients with acute coronary syndromes.

PubMed

Felice, Francesca; Di Stefano, Rossella; Pini, Stefano; Mazzotta, Gianfranco; Bovenzi, Francesco M; Bertoli, Daniele; Abelli, Marianna; Borelli, Lucia; Cardini, Alessandra; Lari, Lisa; Gesi, Camilla; Michi, Paola; Morrone, Doralisa; Gnudi, Luigi; Balbarini, Alberto

2015-05-01

Circulating endothelial progenitor cells (EPCs) are related to endothelial function and progression of coronary artery disease. There is evidence of decreased numbers of circulating EPCs in patients with a current episode of major depression. We investigated the relationships between the level of circulating EPCs and depression and anxiety in patients with acute coronary syndrome (ACS). Patients with ACS admitted to three Cardiology Intensive Care Units were evaluated by the SCID-I to determine the presence of lifetime and/or current mood and anxiety disorders according to DSM-IV criteria. The EPCs were defined as CD133(+) CD34(+) KDR(+) and evaluated by flow cytometry. All patients underwent standardized cardiological and psychopathological evaluations. Parametric and nonparametric statistical tests were performed where appropriate. Out of 111 ACS patients, 57 were found to have a DSM-IV lifetime or current mood or anxiety disorder at the time of the inclusion in the study. The ACS group with mood or anxiety disorders showed a significant decrease in circulating EPC number compared with ACS patients without affective disorders. In addition, EPC levels correlated negatively with severity of depression and anxiety at index ACS episode. The current study indicates that EPCs circulate in decreased numbers in ACS patients with depression or anxiety and, therefore, contribute to explore new perspectives in the pathophysiology of the association between cardiovascular disorders and affective disorders. Copyright © 2015 John Wiley & Sons, Ltd.

Atmospheric Circulations of Rocky Planets as Heat Engines

NASA Astrophysics Data System (ADS)

Koll, D. D. B.

2017-12-01

Rocky planets are extremely common in the galaxy and include Earth, Mars, Venus, and hundreds of exoplanets. To understand and compare the climates of these planets, we need theories that are general enough to accommodate drastically different atmospheric and planetary properties. Unfortunately, few such theories currently exist.For Earth, there is a well-known principle that its atmosphere resembles a heat engine - the atmosphere absorbs heat near the surface, at a hot temperature, and emits heat to space in the upper troposphere, at a cold temperature, which allows it to perform work and balance dissipative processes such as friction. However, previous studies also showed that Earth's hydrological cycle uses up a large fraction of the heat engine's work output, which makes it difficult to view other atmospheres as heat engines.In this work I extend the heat engine principle from Earth towards other rocky planets. I explore both dry and moist atmospheres in an idealized general circulation model (GCM), and quantify their work output using entropy budgets. First, I show that convection and turbulent heat diffusion are important entropy sources in dry atmospheres. I develop a scaling that accounts for its effects, which allows me to predict the strength of frictional dissipation in dry atmospheres. There are strong parallels between my scaling and so-called potential intensity theory, which is a seminal theory for understanding tropical cyclones on Earth. Second, I address how moisture affects atmospheric heat engines. Moisture modifies both the thermodynamic properties of air and releases latent heat when water vapor condenses. I explore the impact of both effects, and use numerical simulations to explore the difference between dry and moist atmospheric circulations across a wide range of climates.

SAPS effects on thermospheric winds during the 17 March 2013 storm

NASA Astrophysics Data System (ADS)

Sheng, C.; Lu, G.; Wang, W.; Doornbos, E.; Talaat, E. R.

2017-12-01

Strong subauroral polarization streams (SAPS) were observed by DMSP satellites during the main phase of the 17 March 2013 geomagnetic storm. Both DMSP F18 and GOCE satellites sampled at 19 MLT during this period, providing near-simultaneous measurements of ion drifts and neutral winds near dusk. The fortuitous satellite conjunction allows us to directly examine the SAPS effects on thermospheric winds. In addition, two sets of model runs were carried out for this event: (1) the standard TIEGCM run with high-latitude forcing; (2) the SAPS-TIEGCM run by incoporating an empirical model of SAPS in the subauroral zone. The difference between these two runs represents the influence of SAPS forcing. In particular, we examine ion-neutral coupling at subauroral latitudes through detailed forcing term analysis to determine how the SAPS-related strong westward ion drifts alter thermospheric winds.

Assessing New GRAV-D Airborne Gravimetry Collected over the United States

NASA Astrophysics Data System (ADS)

Holmes, S. A.; Li, X.; Roman, D. R.

2013-12-01

The U.S. National Geodetic Survey [NGS], through their Gravity for the Redefinition of the American Vertical Datum [GRAV-D] program, is updating its terrestrial gravimetry holdings by flying new airborne gravity surveys over a large fraction of the USA and its territories. By 2020, NGS intends that all orthometric heights in the USA will be determined in the field by using a reliable national gravimetric geoid model to transform from geodetic heights obtained from GPS. Towards this end, the newly-collected airborne-gravimety is repeatedly evaluated by using it to support experimental gravitational models and gravimetric geoids, and then comparing these against independent data sets, such as ';satgrav' models (GRACE/GOCE), GPS/Leveling, astronomical vertical defections, and others. Here we show some results from these tests for GRAV-D airborne gravimetry collected over 2012/2013.

3D Groundwater flow model at the Upper Rhine Graben scale to delineate preferential target areas for geothermal projects

NASA Astrophysics Data System (ADS)

Armandine Les Landes, Antoine; Guillon, Théophile; Peter-Borie, Mariane; Rachez, Xavier

2017-04-01

Any deep unconventional geothermal project remains risky because of the uncertainty regarding the presence of the geothermal resource at depth and the drilling costs increasing accordingly. That's why this resource must be located as precisely as possible to increase the chances of successful projects and their economic viability. To minimize the risk, as much information as possible should be gathered prior to any drilling. Usually, the position of the exploration wells of geothermal energy systems is chosen based on structural geology observations, geophysics measurements and geochemical analyses. Confronting these observations to results from additional disciplines should bring more objectivity in locating the region to explore and where to implant the geothermal system. The Upper Rhine Graben (URG) is a tectonically active rift system that corresponds to one branch of the European Cenozoic Rift System where the basin hosts a significant potential for geothermal energy. The large fault network inherited from a complex tectonic history and settled under the sedimentary deposits hosts fluid circulation patterns. Geothermal anomalies are strongly influenced by fluid circulations within permeable structures such as fault zones. In order to better predict the location of the geothermal resource, it is necessary to understand how it is influenced by heat transport mechanisms such as groundwater flow. The understanding of fluid circulation in hot fractured media at large scale can help in the identification of preferential zones at a finer scale where additional exploration can be carried out. Numerical simulations is a useful tool to deal with the issue of fluid circulations through large fault networks that enable the uplift of deep and hot fluids. Therefore, we build a numerical model to study groundwater flow at the URG scale (150 x 130km), which aims to delineate preferential zones. The numerical model is based on a hybrid method using a Discrete Fracture Network (DFN) and 3D elements to simulate groundwater flow in the 3D regional fault network and in sedimentary deposits, respectively. Firstly, the geometry of the 3D fracture network and its hydraulic connections with 3D elements (sedimentary cover) is built in accordance with the tectonic history and based on geological and geophysical evidences. Secondly, data from previous studies and site-specific geological knowledge provide information on the fault zones family sets and on respective hydraulic properties. Then, from the simulated 3D groundwater flow model and based on a particle tracking methodology, groundwater flow paths are constructed. The regional groundwater flow paths results are extracted and analysed to delineate preferential zones to explore at finer scale and so to define the potential positions of the exploration wells. This work is conducted in the framework of the IMAGE project (Integrated Methods for Advanced Geothermal Exploration, grant agreement No. 608553), which aims to develop new methods for better siting of exploitation wells.

Nomadic Political Ontology and Transnational Academic Mobility

ERIC Educational Resources Information Center

Metcalfe, Amy Scott

2017-01-01

Transnational academic mobility is often characterized in relation to terms such as "brain drain", "brain gain", or "brain circulation"--terms that isolate researchers' minds from their bodies, while saying nothing about their political identities as foreign nationals. In this paper, I explore the possibilities of a…

Geothermal heating enhances atmospheric asymmetries on synchronously rotating planets

NASA Astrophysics Data System (ADS)

Haqq-Misra, Jacob; Kopparapu, Ravi Kumar

2015-01-01

Earth-like planets within the liquid water habitable zone of M-type stars may evolve into synchronous rotators. On these planets, the substellar hemisphere experiences perpetual daylight while the opposing antistellar hemisphere experiences perpetual darkness. Because the night-side hemisphere has no direct source of energy, the air over this side of the planet is prone to freeze out and deposit on the surface, which could result in atmospheric collapse. However, general circulation models (GCMs) have shown that atmospheric dynamics can counteract this problem and provide sufficient energy transport to the antistellar side. Here, we use an idealized GCM to consider the impact of geothermal heating on the habitability of synchronously rotating planets. Geothermal heating may be expected due to tidal interactions with the host star, and the effects of geothermal heating provide additional habitable surface area and may help to induce melting of ice on the antistellar hemisphere. We also explore the persistence of atmospheric asymmetries between the Northern and Southern hemispheres, and we find that the direction of the meridional circulation (for rapidly rotating planets) or the direction of zonal wind (for slowly rotating planets) reverses on either side of the substellar point. We show that the zonal circulation approaches a theoretical state similar to a Walker circulation only for slowly rotating planets, while rapidly rotating planets show a zonal circulation with the opposite direction. We find that a cross-polar circulation is present in all cases and provides an additional mechanism of mass and energy transport from the substellar to antistellar point. Characterization of the atmospheres of synchronously rotating planets should include consideration of hemispheric differences in meridional circulation and examination of transport due to cross-polar flow.

Simple Model of the Circulation.

ERIC Educational Resources Information Center

Greenway, Clive A.

1980-01-01

Describes a program in BASIC-11 that explores the relationships between various variables in the circulatory system and permits manipulation of several semiindependent variables to model the effects of hemorrhage, drug infusions, etc. A flow chart and accompanying sample printout are provided; the program is listed in the appendix. (CS)

The Circulation of European Educational Theories and Practices: The Algerian Experience.

ERIC Educational Resources Information Center

Miliani, Mohamed

1996-01-01

Explores the historical development of education in modern Algeria, arguing that Algeria, despite interest in celebrating the national identity, is still characterized by the wholesale adoption of European educational theories, policies, and practices, even though these do not fit well with indigenous culture. (SLD)

A personal history of the human exploration initiative with commentary on the pivotal role for life support research

NASA Technical Reports Server (NTRS)

Mendell, Wendell

1990-01-01

The author relates the history of the human exploration initiative from a personal perspective from the 1961 J. F. Kennedy initiative to land a man on the moon up to 1986 when a memo was circulated from NASA Headquarters to its employees which stated as a major goal the expansion of the human presence beyond Earth into the solar system. The pivotal role of life support research is woven into this personalized history.

Influenza Vaccine Effectiveness in the Netherlands from 2003/2004 through 2013/2014: The Importance of Circulating Influenza Virus Types and Subtypes

PubMed Central

Dijkstra, Frederika; van Doorn, Eva; Bijlsma, Maarten J.; Donker, Gé A.; de Lange, Marit M. A.; Cadenau, Laura M.; Hak, Eelko; Meijer, Adam

2017-01-01

Influenza vaccine effectiveness (IVE) varies over different influenza seasons and virus (sub)types/lineages. To assess the association between IVE and circulating influenza virus (sub)types/lineages, we estimated the overall and (sub)type specific IVE in the Netherlands. We conducted a test-negative case control study among subjects with influenza-like illness or acute respiratory tract infection consulting the Sentinel Practices over 11 influenza seasons (2003/2004 through 2013/2014) in the Netherlands. The adjusted IVE was estimated using generalized linear mixed modelling and multiple logistic regression. In seven seasons vaccine strains did not match the circulating viruses. Overall adjusted IVE was 40% (95% CI 18 to 56%) and 20% (95% CI -5 to 38%) when vaccine (partially)matched and mismatched the circulating viruses, respectively. When A(H3N2) was the predominant virus, IVE was 38% (95% CI 14 to 55%). IVE against infection with former seasonal A(H1N1) virus was 83% (95% CI 52 to 94%), and with B virus 67% (95% CI 55 to 76%). In conclusion IVE estimates were particularly low when vaccine mismatched the circulating viruses and A(H3N2) was the predominant influenza virus subtype. Tremendous effort is required to improve vaccine production procedure and to explore the factors that influence the IVE against A(H3N2) virus. PMID:28068386

Modeling the Impact of Fjord-glacier Geometry on Subglacial Plume, Wind, and Tidally-forced Circulation in Outlet Glacier Fjords

NASA Astrophysics Data System (ADS)

Carroll, D.; Sutherland, D.; Nash, J. D.; Shroyer, E.; de Steur, L.; Catania, G. A.; Stearns, L. A.

2016-12-01

The acceleration, retreat, and thinning of Greenland's outlet glaciers coincided with a warming of Atlantic waters, suggesting that marine-terminating glaciers are sensitive to ocean forcing. However, we still lack a precise understanding of what factors control the variability of ocean heat transport toward the glacier terminus. Here we use an idealized ocean general circulation model (3D MITgcm) to systematically evaluate how fjord circulation driven by subglacial plumes, wind stress (along-fjord and along-shelf), and tides depends on grounding line depth, fjord width, sill height, and latitude. Our results indicate that while subglacial plumes in deeply grounded systems can draw shelf waters over a sill and toward the glacier, shallowly grounded systems require external forcing to renew basin waters. We use a coupled sea ice model to explore the competing influence of tidal mixing and surface buoyancy forcing on fjord stratification. Passive tracers injected in the plume, fjord basin, and shelf waters are used to quantify turnover timescales. Finally, we compare our model results with a two-year mooring record to explain fundamental differences in observed circulation and hydrography in Rink Isbræ and Kangerlussuup Sermia fjords in west Greenland. Our results underscore the first-order effect that geometry has in controlling fjord circulation and, thus, ocean heat flux to the ice.

Mapping the Intricacies of the Gulf of Mexico's Circulation

NASA Astrophysics Data System (ADS)

Lugo-Fernández, Alexis; Green, Rebecca E.

2011-01-01

From hosting key shipping lines, drilling platforms, and commercial fisheries, to sustaining mangrove swamps that shelter the coastline from the hurricanes that churn its waters, the Gulf of Mexico is important to the nations surrounding it for socio-economic, ecological, military, political, and scientific reasons. Critical to all of these sectors is the Gulf's circulation—it controls hurricane tracks and intensity, biological productivity, and larvae dispersal. Since 1982, the Environmental Studies Program (ESP) of the U.S. Bureau of Ocean Energy Management, Regulation and Enforcement (BOEMRE) has invested more than $67 million in field and numerical modeling studies to improve our understanding of the Gulf's circulation (see Figure 1). ESP-funded research has covered a broad array of topics, some applied and some basic. Studies carried out on behalf of the bureau reflect the bureau's information needs, stakeholder input, and offshore energy exploration and development trends. All ESP studies culminate in a technical report—127 technical reports on physical oceanography are publicly available (see http://www.gomr.boemre.gov/homepg/regulate/environ/techsumm/rec_pubs.html). Additionally, more than 100 peer-reviewed publications have been issued on the Gulf's physical oceanography and circulation. The AGU Geophysical Monograph Circulation in the Gulf of Mexico: Observations and Models, the very first circulation overview since 1972, was funded by ESP. Additionally, data collected during fieldwork are deposited in national archives for public dissemination.

Immunoglobulins against Tyrosine Nitrated Epitopes in Coronary Artery Disease

PubMed Central

Thomson, Leonor; Tenopoulou, Margarita; Lightfoot, Richard; Tsika, Epida; Parastatidis, Ioannis; Martinez, Marissa; Greco, Todd M.; Doulias, Paschalis-Thomas; Wu, Yuping; Tang, W. H. Wilson; Hazen, Stanley L.; Ischiropoulos, Harry

2012-01-01

Background Several lines of evidence support a pathophysiological role of immunity in atherosclerosis. Tyrosine nitrated proteins, a footprint of oxygen and nitrogen derived oxidants generated by cells of the immune system, are enriched in atheromatous lesions and in circulation of coronary artery disease (CAD) subjects. However, the consequences of possible immune reactions triggered by the presence of nitrated proteins in subjects with clinically documented atherosclerosis have not been explored. Methods and Results Specific immunoglobulins that recognize 3-nitrotyrosine epitopes were identified in human lesions, as well as in circulation of CAD subjects. The levels of circulating immunoglobulins against 3-nitrotyrosine epitopes were quantified in CAD patients (n=374) and subjects without CAD (non CAD controls, n=313). A ten-fold increase in the mean level of circulating immunoglobulins against protein-bound 3-nitrotyrosine was documented in the CAD subjects (3.75 ± 1.8 μg antibody Eq/mL plasma vs. 0.36 ± 0.8 μg antibody Eq/mL plasma), and was strongly associated with angiographic evidence of significant CAD. Conclusions The results of this cross sectional study suggest that post-translational modification of proteins via nitration within atherosclerotic plaque-laden arteries and in circulation serve as neoepitopes for elaboration of immunoglobulins, thereby providing an association between oxidant production and the activation of the immune system in CAD. PMID:23081989

Understanding the Central Equatorial African long-term drought using AMIP-type simulations

NASA Astrophysics Data System (ADS)

Hua, Wenjian; Zhou, Liming; Chen, Haishan; Nicholson, Sharon E.; Jiang, Yan; Raghavendra, Ajay

2018-02-01

Previous studies show that Indo-Pacific sea surface temperature (SST) variations may help to explain the observed long-term drought during April-May-June (AMJ) since the 1990s over Central equatorial Africa (CEA). However, the underlying physical mechanisms for this drought are still not clear due to observation limitations. Here we use the AMIP-type simulations with 24 ensemble members forced by observed SSTs from the ECHAM4.5 model to explore the likely physical processes that determine the rainfall variations over CEA. We not only examine the ensemble mean (EM), but also compare the "good" and "poor" ensemble members to understand the intra-ensemble variability. In general, EM and the "good" ensemble member can simulate the drought and associated reduced vertical velocity and anomalous anti-cyclonic circulation in the lower troposphere. However, the "poor" ensemble members cannot simulate the drought and associated circulation patterns. These contrasts indicate that the drought is tightly associated with the tropical Walker circulation and atmospheric teleconnection patterns. If the observational circulation patterns cannot be reproduced, the CEA drought will not be captured. Despite the large intra-ensemble spread, the model simulations indicate an essential role of SST forcing in causing the drought. These results suggest that the long-term drought may result from tropical Indo-Pacific SST variations associated with the enhanced and westward extended tropical Walker circulation.

Mathematical modelling of the maternal cardiovascular system in the three stages of pregnancy.

PubMed

Corsini, Chiara; Cervi, Elena; Migliavacca, Francesco; Schievano, Silvia; Hsia, Tain-Yen; Pennati, Giancarlo

2017-09-01

In this study, a mathematical model of the female circulation during pregnancy is presented in order to investigate the hemodynamic response to the cardiovascular changes associated with each trimester of pregnancy. First, a preliminary lumped parameter model of the circulation of a non-pregnant female was developed, including the heart, the systemic circulation with a specific block for the uterine district and the pulmonary circulation. The model was first tested at rest; then heart rate and vascular resistances were individually varied to verify the correct response to parameter alterations characterising pregnancy. In order to simulate hemodynamics during pregnancy at each trimester, the main changes applied to the model consisted in reducing vascular resistances, and simultaneously increasing heart rate and ventricular wall volumes. Overall, reasonable agreement was found between model outputs and in vivo data, with the trends of the cardiac hemodynamic quantities suggesting correct response of the heart model throughout pregnancy. Results were reported for uterine hemodynamics, with flow tracings resembling typical Doppler velocity waveforms at each stage, including pulsatility indexes. Such a model may be used to explore the changes that happen during pregnancy in female with cardiovascular diseases. Crown Copyright © 2017. Published by Elsevier Ltd. All rights reserved.

Mesoscale mixing of the Denmark Strait Overflow in the Irminger Basin

NASA Astrophysics Data System (ADS)

Koszalka, Inga M.; Haine, Thomas W. N.; Magaldi, Marcello G.

2017-04-01

The Denmark Strait Overflow (DSO) is a major export route for dense waters from the Nordic Seas forming the lower limb of the Atlantic Meridional Overturning Circulation, an important element of the climate system. Mixing processes along the DSO pathway influence its volume transport and properties contributing to the variability of the deep overturning circulation. They are poorly sampled by observations, however, which hinders development of a proper DSO representation in global circulation models. We employ a high resolution regional ocean model of the Irminger Basin to quantify impact of the mesoscale flows on DSO mixing focusing on geographical localization and the time-modulation of water property changes. The model reproduces the observed bulk warming of the DSO plume 100-200 km downstream of the Denmark Strait sill. It also reveals that mesoscale variability of the overflow ('DSO-eddies', of 20-30 km extent and a time scale of 2-5 day) modulates water property changes and turbulent mixing, diagnosed with the vertical shear of horizontal velocity and the eddy heat flux divergence. The space-time localization of the DSO mixing and warming and the role of coherent mesoscale structures should be explored by turbulence measurements and factored into the coarse circulation models.

Meteorological predictions for Mars 2020 Exploration Rover high-priority landing sites throug MRAMS Mesoscale Modeling

NASA Astrophysics Data System (ADS)

Pla-García, Jorge; Rafkin, Scot C. R.

2015-04-01

The Mars Regional Atmospheric Modeling System (MRAMS) is used to predict meteorological conditions that are likely to be encountered by the Mars 2020 Exploration Rover at several proposed landing sites during entry, descent, and landing (EDL). The meteorology during the EDL window at most of the sites is dynamic. The intense heating of the lower atmosphere drives intense thermals and mesoscale thermal circulations. Moderate mean winds, wind shear, turbulence, and vertical air currents associated with convection are present and potentially hazardous to EDL [1]. Nine areas with specific high-priority landing ellipses of the 2020 Rover, are investigated: NE Syrtis, Nili Fossae, Nili Fossae Carbonates, Jezero Crater Delta, Holden Crater, McLaughlin Crater, Southwest Melas Basin, Mawrth Vallis and East Margaritifer Chloride. MRAMS was applied to the landing site regions using nested grids with a spacing of 330 meters on the innermost grid that is centered over each landing site. MRAMS is ideally suited for this investigation; the model is explicitly designed to simulate Mars' atmospheric thermal circulations at the mesoscale and smaller with realistic, high-resolution surface properties [2, 3]. Horizontal wind speeds, both vertical profiles and vertical cross-sections wind speeds, are studied. For some landing sites simulations, two example configurations -including and not including Hellas basin in the mother domain- were generated, in order to study how the basin affects the innermost grids circulations. Afternoon circulations at all sites pose some risk entry, descent, and landing. Most of the atmospheric hazards are not evident in current observational data and general circulation model simulations and can only be ascertained through mesoscale modeling of the region. Decide where to go first and then design a system that can tolerate the environment would greatly minimize risk. References: [1] Rafkin, S. C. R., and T. I. Michaels (2003), J. Geophys. Res., 108(E12), 8091. [2] Rafkin, S. C. R., R. M. Haberle, and T. I. Michaels (2001), Icarus, 151, 228-256.
[3] Rafkin, S. C. R., M. R. V. Sta. Maria, and T. I. Michaels (2002), Nature, 419, 697-699.

Circulating levels of C-reactive protein, interleukin-6 and tumor necrosis factor-α and risk of colorectal adenomas: a meta-analysis.

PubMed

Zhang, Xiaoqian; Liu, Shanglong; Zhou, Yanbing

2016-09-27

Results from publications on inflammatory markers of C-reactive protein (CRP), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) and risk of colorectal adenomas are not consistent. A meta-analysis was conducted to explore the above-mentioned associations. Relevant studies were identified by a search of Embase, Medline and PubMed through February 2016. A random effect model was adopted to combine study-specific odds ratio (OR) and 95% confidence interval (95% CI). Between-study heterogeneity and publications bias were assessed. Dose-response relationships were assessed by restricted cubic splines. Nineteen observational studies were included. For highest vs. lowest levels, results from this meta-analysis did not support an association between circulating levels of CRP [OR (95% CI): 1.15 (0.94-1.40)], IL-6 [1.17 (0.94-1.46)] and TNF-α [0.99 (0.75-1.31)] and risk of colorectal adenomas, respectively. The findings were supported by sensitivity analysis and subgroup analysis. In dose-response analysis, the risk of colorectal adenomas increased by 2% [1.02 (0.97-1.08)] for each 1 mg/L increment in circulation CRP levels, 9% [1.09 (0.91-1.31)] for each 1 ng/L increment in circulation IL-6 levels, and 6% [1.06 (0.93-1.21)] for each 1 pg/mL increment in circulation TNF-α levels. Moderate between-study heterogeneity was found. No evidence of publication bias was found. Circulation levels of CRP, IL-6 and TNF-α might be not useful biomarkers for identifying colorectal adenomas, respectively.

Small Library Automation: Information and Issues. Bulletin No. 91491.

ERIC Educational Resources Information Center

Wisconsin State Dept. of Public Instruction, Madison.

Highlighting the issues that confront small libraries who are exploring automation options, this report focuses on microcomputer-based automation systems for circulation and an online patron access catalog (OPAC). The information provided outlines some of the questions that librarians must ask themselves or vendors before they select a specific…

Moments of Transculturation and Assimilation: Post-Colonial Explorations of Supervision and Culture

ERIC Educational Resources Information Center

Manathung, Catherine

2011-01-01

Dynamic interplays of identity circulate within any form of supervision. When supervisors and students also originate from diverse cultures, these complex forces become overlaid with additional cultural factors that must be taken into account in supervision pedagogy. Previous colonial discourses, stereotypes, and histories may surface in…

Hybrid Citizenship: Latina Youth and the Politics of Belonging

ERIC Educational Resources Information Center

Bondy, Jennifer M.

2015-01-01

Drawing from interview data collected from high school students in Broward County, Florida, this article explores how eight adolescent Latinas understand citizenship and belonging vis-à-vis circulating images and discourses on Latina/o immigration, immigrant, and Latina. The author examines Latina youths' citizenship identities and belonging using…

THE IMPACT OF BUILDING TOPOGRAPHY ON AEROSOL DISPERSION IN AN URBAN STREET CANYON

EPA Science Inventory

This extended abstract describes numerical simulations of the flow through a building array which includes an isolated tall tower. The work seeks to explore the impact of a single tall building on the circulation and channeling of aerosolized traffic emissions within a series of...

Locating the Subject: Teens Online @ ninemsn

ERIC Educational Resources Information Center

Atkinson, Stephen; Nixon, Helen

2005-01-01

In this paper we examine how the figure of the teenager is positioned within the discourses and practices of commercial online media. In particular, we explore how the popular, Australia-based web portal "ninemsn" works discursively to shape the identities of young people. Ninemsn not only constructs and circulates selected…

Left to Chance: Gifted Students and Recreational Reading

ERIC Educational Resources Information Center

Churchill, Sara J.

2017-01-01

This qualitative multiple case study explored the factors that impact the recreational reading selections of gifted students. Eleven students in grades four and five participated in the study. The methods of data collection included in-depth personal interviews and analysis of library circulation records and independent reading program data. The…

Swarm- Validation of Star Tracker and Accelerometer Data

NASA Astrophysics Data System (ADS)

Schack, Peter; Schlicht, Anja; Pail, Roland; Gruber, Thomas

2016-08-01

The ESA Swarm mission is designed to advance studies in the field of magnetosphere, thermosphere and gravity field. To be fortunate on this task precise knowledge of the orientation of the Swarm satellites is required together with knowledge about external forces acting on the satellites. The key sensors providing this information are the star trackers and the accelerometers. Based on star tracker studies conducted by the Denmark Technical University (DTU), we found interesting patterns in the interboresight angles on all three satellites, which are partly induced by temperature alterations. Additionally, structures of horizontal stripes seem to be caused by the unique distribution of observed stars on the charge-coupled device of the star trackers. Our accelerometer analyses focus on spikes and pulses in the observations. Those short term events on Swarm might originate from electrical processes introduced by sunlight illuminating the nadir foil. Comparisons to GOCE and GRACE are included.

Direct Fabrication of the Graphene-Based Composite for Cancer Phototherapy through Graphite Exfoliation with a Photosensitizer.

PubMed

Liu, Gang; Qin, Hongmei; Amano, Tsukuru; Murakami, Takashi; Komatsu, Naoki

2015-10-28

We report on the application of pristine graphene as a drug carrier for phototherapy (PT). The loading of a photosensitizer, chlorin e6 (Ce6), was achieved simply by sonication of Ce6 and graphite in an aqueous solution. During the loading process, graphite was gradually exfoliated to graphene to give its composite with Ce6 (G-Ce6). This one-step approach is considered to be superior to the graphene oxide (GO)-based composites, which required pretreatment of graphite by strong oxidation. Additionally, the directly exfoliated graphene ensured a high drug loading capacity, 160 wt %, which is about 10 times larger than that of the functionalized GO. Furthermore, the Ce6 concentration for killing cells by G-Ce6 is 6-75 times less than that of the other Ce6 composites including GO-Ce6.

Evaluation of gravitational gradients generated by Earth's crustal structures

NASA Astrophysics Data System (ADS)

Novák, Pavel; Tenzer, Robert; Eshagh, Mehdi; Bagherbandi, Mohammad

2013-02-01

Spectral formulas for the evaluation of gravitational gradients generated by upper Earth's mass components are presented in the manuscript. The spectral approach allows for numerical evaluation of global gravitational gradient fields that can be used to constrain gravitational gradients either synthesised from global gravitational models or directly measured by the spaceborne gradiometer on board of the GOCE satellite mission. Gravitational gradients generated by static atmospheric, topographic and continental ice masses are evaluated numerically based on available global models of Earth's topography, bathymetry and continental ice sheets. CRUST2.0 data are then applied for the numerical evaluation of gravitational gradients generated by mass density contrasts within soft and hard sediments, upper, middle and lower crust layers. Combined gravitational gradients are compared to disturbing gravitational gradients derived from a global gravitational model and an idealised Earth's model represented by the geocentric homogeneous biaxial ellipsoid GRS80. The methodology could be used for improved modelling of the Earth's inner structure.

Mean Dynamic Topography of the Arctic Ocean

NASA Technical Reports Server (NTRS)

Farrell, Sinead Louise; Mcadoo, David C.; Laxon, Seymour W.; Zwally, H. Jay; Yi, Donghui; Ridout, Andy; Giles, Katherine

2012-01-01

ICESat and Envisat altimetry data provide measurements of the instantaneous sea surface height (SSH) across the Arctic Ocean, using lead and open water elevation within the sea ice pack. First, these data were used to derive two independent mean sea surface (MSS) models by stacking and averaging along-track SSH profiles gathered between 2003 and 2009. The ICESat and Envisat MSS data were combined to construct the high-resolution ICEn MSS. Second, we estimate the 5.5-year mean dynamic topography (MDT) of the Arctic Ocean by differencing the ICEn MSS with the new GOCO02S geoid model, derived from GRACE and GOCE gravity. Using these satellite-only data we map the major features of Arctic Ocean dynamical height that are consistent with in situ observations, including the topographical highs and lows of the Beaufort and Greenland Gyres, respectively. Smaller-scale MDT structures remain largely unresolved due to uncertainties in the geoid at short wavelengths.

TLE uncertainty estimation using robust weighted differencing

NASA Astrophysics Data System (ADS)

Geul, Jacco; Mooij, Erwin; Noomen, Ron

2017-05-01

Accurate knowledge of satellite orbit errors is essential for many types of analyses. Unfortunately, for two-line elements (TLEs) this is not available. This paper presents a weighted differencing method using robust least-squares regression for estimating many important error characteristics. The method is applied to both classic and enhanced TLEs, compared to previous implementations, and validated using Global Positioning System (GPS) solutions for the GOCE satellite in Low-Earth Orbit (LEO), prior to its re-entry. The method is found to be more accurate than previous TLE differencing efforts in estimating initial uncertainty, as well as error growth. The method also proves more reliable and requires no data filtering (such as outlier removal). Sensitivity analysis shows a strong relationship between argument of latitude and covariance (standard deviations and correlations), which the method is able to approximate. Overall, the method proves accurate, computationally fast, and robust, and is applicable to any object in the satellite catalogue (SATCAT).

Play-fairway analysis for geothermal resources and exploration risk in the Modoc Plateau region

USGS Publications Warehouse

Siler, Drew; Zhang, Yingqi; Spycher, Nicolas F.; Dobson, Patrick; McClain, James S.; Gasperikova, Erika; Zierenberg, Robert A.; Schiffman, Peter; Ferguson, Colin; Fowler, Andrew; Cantwell, Carolyn

2017-01-01

The region surrounding the Modoc Plateau, encompassing parts of northeastern California, southern Oregon, and northwestern Nevada, lies at an intersection between two tectonic provinces; the Basin and Range province and the Cascade volcanic arc. Both of these provinces have substantial geothermal resource base and resource potential. Geothermal systems with evidence of magmatic heat, associated with Cascade arc magmatism, typify the western side of the region. Systems on the eastern side of the region appear to be fault controlled with heat derived from high crustal heat flow, both of which are typical of the Basin and Range. As it has the potential to host Cascade arc-type geothermal resources, Basin and Range-type geothermal resources, and/or resources with characteristics of both provinces, and because there is relatively little current development, the Modoc Plateau region represents an intriguing potential for undiscovered geothermal resources. It remains unclear however, what specific set(s) of characteristics are diagnostic of Modoc-type geothermal systems and how or if those characteristics are distinct from Basin and Range-type or Cascade arc-type geothermal systems. In order to evaluate the potential for undiscovered geothermal resources in the Modoc area, we integrate a wide variety of existing data in order to evaluate geothermal resource potential and exploration risk utilizing ‘play-fairway’ analysis. We consider that the requisite parameters for hydrothermal circulation are: 1) heat that is sufficient to drive circulation, and 2) permeability that is sufficient to allow for fluid circulation in the subsurface. We synthesize data that indicate the extent and distribution of these parameters throughout the Modoc region. ‘Fuzzy logic’ is used to incorporate expert opinion into the utility of each dataset as an indicator of either heat or permeability, and thus geothermal favorability. The results identify several geothermal prospects, areas that are highly favorable for the occurrence of both heat and permeability. These are also areas where there is sufficient data coverage, quality, and consistency that the exploration risk is relatively low. These unknown, undeveloped, and under-developed prospects are well-suited for continued exploration efforts. The results also indicate to what degree the two ‘play-types,’ i.e. Cascade arc-type or Basin and Range-type, apply to each of the geothermal prospects, a useful guide in exploration efforts.

The global geochemistry of bomb-produced tritium - General circulation model compared to available observations and traditional interpretations

NASA Technical Reports Server (NTRS)

Koster, Randal D.; Broecker, Wallace S.; Jouzel, Jean; Suozzo, Robert J.; Russell, Gary L.; Rind, David

1989-01-01

Observational evidence suggests that of the tritium produced during nuclear bomb tests that has already reached the ocean, more than twice as much arrived through vapor impact as through precipitation. In the present study, the Goddard Institute for Space Studies 8 x 10 deg atmospheric general circulation model is used to simulate tritium transport from the upper atmosphere to the ocean. The simulation indicates that tritium delivery to the ocean via vapor impact is about equal to that via precipitation. The model result is relatively insensitive to several imposed changes in tritium source location, in model parameterizations, and in model resolution. Possible reasons for the discrepancy are explored.

Atlantic Water transformation in the Nordic Seas and its influence on the export rate of the Overflow Waters

NASA Astrophysics Data System (ADS)

Garcia Quintana, Yarisbel; Wiesner, Pia; Hu, Xianmin; Myers, Paul

2017-04-01

The Nordic Seas (NS) are the main gateway between the Arctic and the Atlantic Oceans. The basin can be considered as the headwaters for the Meridional Overturning Circulation (MOC), for it is there that the Denmark Strait Overflow Water (DSOW) and the Iceland-Scotland Overflow Water (ISOW) acquire their properties. Their inflow into the North Atlantic Ocean occurs across the Greenland-Scotland ridge. Together with Labrador Sea Water, DSOW and ISOW are the main components of the North Atlantic Deep Water (NADW), which ventilates the lower limb of the Atlantic MOC. In spite recent studies exploring the export rate and later pathways of the overflows, the question about what drives them, remains. Here we explore the transformation of the Atlantic Water (AW) as it enters the NS through Denmark Strait, Iceland Faroe Ridge and Faroe Schotland Channel, as well as its pathways within the basin. To do so, we use an eddy-permitting ocean general circulation model run over the period 2002 to 2015. Two different approaches are used to track the AW transformation in the NS: the well-tested off-line Lagrangian tool ARIANE and on-line passive tracers. In both cases we use the same definition of AW to tag its inflow through the three entering sections. The overflows directly impact circulation and water properties in much of the deep Atlantic Ocean, thus a better understanding of the physical processes behind their variability is crucial a asset.

['Piracy of kowledge'--the role of a buccaneer-scientist in the knowledge circulation around diseases and drugs in the tropics].

PubMed

Snelders, Stephen

2009-01-01

Knowledge circulation in the seventeenth and eighteenth centuries was not only stimulated by the mutual interaction of trade and science. In the context of territorial expansion, war, and the activities of privateers and pirates, knowledge of diseases and drugs in the tropics was increased as well. An important part in this process was performed by so-called 'buccaneer-scientists': adventurers with medical and scientific backgrounds and/or interest who operated on the cultural borders in different parts of the hemisphere. The characteristics of this type of contributor to Early Modern knowledge circulation are explored and analyzed in the example of Scottish surgeon and pirate Lionel Wafer (c. 1660 - c. 1705). The buccaneer scientist had to share the passions of other scientists, resulting in accurate and detailed empirical observation; be able to judge the relevance of observations and 'facts'; be part of a context that stimulates these observations; be capable of describing of these observations; and be part of a network of dissemination of observations. His activities should have an important practical and pragmatic component stimulating trade, expansion and even piracy. And he should possess personal characteristics such as perseverance, a healthy constitution, and ruthlessness, to work and survive in a violent and traumatic environment. Wafer is typical for other 'buccaneer-scientists' of this period--not only pirates and privateers, but also physicians and natural explorers operating in other and more 'respectable' areas of the European overseas expansion.

Skin-resident memory CD4+ T cells enhance protection against Leishmania major infection.

PubMed

Glennie, Nelson D; Yeramilli, Venkata A; Beiting, Daniel P; Volk, Susan W; Weaver, Casey T; Scott, Phillip

2015-08-24

Leishmaniasis causes a significant disease burden worldwide. Although Leishmania-infected patients become refractory to reinfection after disease resolution, effective immune protection has not yet been achieved by human vaccines. Although circulating Leishmania-specific T cells are known to play a critical role in immunity, the role of memory T cells present in peripheral tissues has not been explored. Here, we identify a population of skin-resident Leishmania-specific memory CD4+ T cells. These cells produce IFN-γ and remain resident in the skin when transplanted by skin graft onto naive mice. They function to recruit circulating T cells to the skin in a CXCR3-dependent manner, resulting in better control of the parasites. Our findings are the first to demonstrate that CD4+ TRM cells form in response to a parasitic infection, and indicate that optimal protective immunity to Leishmania, and thus the success of a vaccine, may depend on generating both circulating and skin-resident memory T cells. © 2015 Glennie et al.

Skin-resident memory CD4+ T cells enhance protection against Leishmania major infection

PubMed Central

Glennie, Nelson D.; Yeramilli, Venkata A.; Beiting, Daniel P.; Volk, Susan W.; Weaver, Casey T.

2015-01-01

Leishmaniasis causes a significant disease burden worldwide. Although Leishmania-infected patients become refractory to reinfection after disease resolution, effective immune protection has not yet been achieved by human vaccines. Although circulating Leishmania-specific T cells are known to play a critical role in immunity, the role of memory T cells present in peripheral tissues has not been explored. Here, we identify a population of skin-resident Leishmania-specific memory CD4+ T cells. These cells produce IFN-γ and remain resident in the skin when transplanted by skin graft onto naive mice. They function to recruit circulating T cells to the skin in a CXCR3-dependent manner, resulting in better control of the parasites. Our findings are the first to demonstrate that CD4+ TRM cells form in response to a parasitic infection, and indicate that optimal protective immunity to Leishmania, and thus the success of a vaccine, may depend on generating both circulating and skin-resident memory T cells. PMID:26216123

Impacts of Early Summer Eurasian Snow Cover Change on Atmospheric Circulation in Northern Mid-Latitudes

NASA Astrophysics Data System (ADS)

Nozawa, T.

2016-12-01

Recently, Japan Aerospace Exploration Agency (JAXA) has developed a new long-term snow cover extent (SCE) product using Advanced Very High Resolution Radiometer (AVHRR) and Moderate Resolution Imaging Spectroradiometer (MODIS) data spanning from 1980's to date. This new product (JAXA/SCE) has higher spatial resolution and smaller commission error compared with traditional SCE dataset of National Oceanic and Atmospheric Administration (NOAA/SCE). Continuity of the algorithm is another strong point in JAXA/SCE. According to the new JAXA/SCE dataset, the Eurasian SCE has been significantly retreating since 1980's, especially in late spring and early summer. Here, we investigate impacts of early summer Eurasian snow cover change on atmospheric circulation in Northern mid-latitudes, especially over the East Asia, using the new JAXA/SCE dataset and a few reanalysis data. We will present analyzed results on relationships between early summer SCE anomaly over the Eurasia and changes in atmospheric circulations such as upper level zonal jets (changes in strength, positions, etc.) over the East Asia.

Orography and the Boreal Winter Stratosphere: The Importance of the Mongolian Mountains

NASA Astrophysics Data System (ADS)

White, R. H.; Battisti, D. S.; Sheshadri, A.

2018-02-01

The impact of mountains on stratospheric circulation is explored using the Whole Atmosphere Community Climate Model. The "Mongolian mountains" decrease the boreal winter stratospheric jet strength by ˜1/3 and increase the frequency of major sudden stratospheric warmings from 0.08 year-1 to the observed 0.60 year-1. These changes are twice the magnitude of the impacts of the Tibetan plateau and Himalayas. Consistent with the decrease in the zonal jet, there is enhanced Eliassen-Palm flux convergence; this is predominantly from changes in wave propagation pathways through changes to the upper troposphere circulation, not from an increased amplitude of planetary waves reaching the stratosphere. The Mongolian mountains have the greater impact on upper tropospheric circulation due to their meridional location. The Rocky Mountains have no significant impact on the stratospheric jet. Changes in wave propagation in response to the Mongolian mountains are similar to those associated with major sudden stratospheric warming events in observations.

Experimental Myocardial Infarction Upregulates Circulating Fibroblast Growth Factor-23.

PubMed

Andrukhova, Olena; Slavic, Svetlana; Odörfer, Kathrin I; Erben, Reinhold G

2015-10-01

Myocardial infarction (MI) is a major cause of death worldwide. Epidemiological studies have linked vitamin D deficiency to MI incidence. Because fibroblast growth factor-23 (FGF23) is a master regulator of vitamin D hormone production and has been shown to be associated with cardiac hypertrophy per se, we explored the hypothesis that FGF23 may be a previously unrecognized pathophysiological factor causally linked to progression of cardiac dysfunction post-MI. Here, we show that circulating intact Fgf23 was profoundly elevated, whereas serum vitamin D hormone levels were suppressed, after induction of experimental MI in rat and mouse models, independent of changes in serum soluble Klotho or serum parathyroid hormone. Both skeletal and cardiac expression of Fgf23 was increased after MI. Although the molecular link between the cardiac lesion and circulating Fgf23 concentrations remains to be identified, our study has uncovered a novel heart-bone-kidney axis that may have important clinical implications and may inaugurate the new field of cardio-osteology. © 2015 American Society for Bone and Mineral Research.

The Canary Basin contribution to the seasonal cycle of the Atlantic Meridional Overturning Circulation at 26°N

NASA Astrophysics Data System (ADS)

Pérez-Hernández, M. D.; McCarthy, G. D.; Vélez-Belchí, P.; Smeed, D. A.; Fraile-Nuez, E.; Hernández-Guerra, A.

2015-11-01

This study examines the seasonal cycle of the Atlantic Meridional Overturning Circulation (AMOC) and its eastern boundary contributions. The cycle has a magnitude of 6 Sv, as measured by the RAPID/MOCHA/WBTS project array at 26°N, which is driven largely by the eastern boundary. The eastern boundary variations are explored in the context of the regional circulation around the Canary Islands. There is a 3 month lag between maximum wind forcing and the largest eastern boundary transports, which is explained in terms of a model for Rossby wave generated at the eastern boundary. Two dynamic processes take place through the Lanzarote Passage (LP) in fall: the recirculation of the Canary Current and the northward flow of the Intermediate Poleward Undercurrent. In contrast, during the remaining seasons the transport through the LP is southward due to the Canary Upwelling Current. These processes are linked to the seasonal cycle of the AMOC.

Helical circulations in the typhoon boundary layer

NASA Astrophysics Data System (ADS)

Ellis, Ryan; Businger, Steven

2010-03-01

Low-level wind data from the WSR-88D in Guam obtained in Typhoon Dale (1996) and Typhoon Keith (1997) are analyzed for coherent structures. Consistent with the results of previous studies of Atlantic hurricanes, velocity anomalies associated with coherent structures were found in the boundary layer of both storms. A total of 99 cases of coherent structures, also known as roll vortices, were documented during a 6 h evaluation period for each storm. Storm-relative roll location, roll vorticity, asymmetries in the upward and downward momentum fluxes, and signatures of circulations transverse to the mean flow associated with roll circulations were explored. The effects of terrain and convective precipitation systems, such as rainbands, on the occurrence of rolls were investigated. The results support and extend prior findings of roll observations, and can be used to help validate theoretical and numerical models of coherent structures within tropical cyclones. Moreover, the wind variations documented in this study may have application for wave runup and wind damage potential in tropical cyclones.

Circulation Control in NASA's Vehicle Systems

NASA Technical Reports Server (NTRS)

Rich, Paul; McKinley, Bob; Jones, Greg

2005-01-01

Specific to the application of any technology to a vehicle, such as circulation control, it is important to understand the process that NASA is using to set its direction in research and development. To see how circulation control fits into any given NASA program requires the reader to understand NASA's Vehicle Systems (VS) Program. The VS Program recently celebrated its first year of existence with an annual review - an opportunity to look back on accomplishments, solicit feedback, expand national advocacy and support for the program, and recognize key contributions. Since its formation last year, Vehicle Systems has coordinated seven existing entities in a streamlined aeronautics research effort. It invests in vehicle technologies to protect the environment, make air travel more accessible and affordable for Americans, enable exploration through new aerospace missions, and augment national security. This past year has seen a series of valuable partnerships with industry, academia, and government agencies to make crucial aeronautics advances and assure America s future in flight.

Why nation-states and journalists can't teach people to be healthy: power and pragmatic miscalculation in public discourses on health.

PubMed

Briggs, Charles L

2003-09-01

This article analyzes how Venezuelan public health officials collaborated with journalists in producing information about cholera in January-December 1991. It uses Michael Warner's (2002) observation that such public discourse involves a contradiction: it must project the image of reaching an actually existing public at the same time that it creates multiple publics as it circulates. The analysis explores the language ideologies that hide complex sets of practices, networks, and material conditions that shape how public discourses circulate. At the same time that epidemiologists targeted poor barrio residents, street vendors of food and drink, and indigenous people as being "at high risk," health education messages pictured women in well-equipped kitchens demonstrating cholera prevention measures. The gap between these ideal audiences and the discrepant publics created by their circulation limited the effectiveness of prevention efforts and created a substantial chasm between public health institutions and the publics they sought to reach.

"That Happened to Me Too": Young People's Informal Knowledge of Diverse Genders and Sexualities

ERIC Educational Resources Information Center

Byron, Paul; Hunt, Jessie

2017-01-01

This paper explores how young people of diverse genders and sexualities share information about sex, sexualities and genders. Formal approaches to education often fail to consider young people's communication and information exchange practices, including the circulation of peer knowledge through social media. In the wake of recent Australian…

Discovery of User-Oriented Class Associations for Enriching Library Classification Schemes.

ERIC Educational Resources Information Center

Pu, Hsiao-Tieh

2002-01-01

Presents a user-based approach to exploring the possibility of adding user-oriented class associations to hierarchical library classification schemes. Classes not grouped in the same subject hierarchies yet relevant to users' knowledge are obtained by analyzing a log book of a university library's circulation records, using collaborative filtering…

Media Literacy, Education & (Civic) Capability: A Transferable Methodology

ERIC Educational Resources Information Center

McDougall, Julian; Berger, Richard; Fraser, Pete; Zezulkova, Marketa

2015-01-01

This article explores the relationship between a formal media educational encounter in the UK and the broad objectives for media and information literacy education circulating in mainland Europe and the US. A pilot study, developed with a special interest group of the United Kingdom Literacy Association, applied a three-part methodology for…

"Talent Circulators" in Shanghai: Return Migrants and Their Strategies for Success

ERIC Educational Resources Information Center

Huang, Yedan; Kuah-Pearce, Khun Eng

2015-01-01

This paper argues for a flexible identity and citizenship framework to explore how return migrants, "haigui," have readapted and re-established themselves back into Shanghai society, and how they have used their talents, knowledge and "guanxi" networks to optimise their chances of success. It argues that these return migrants,…

"And the Beat Goes Ona... Building Artificial Hearts in the Classroom.

ERIC Educational Resources Information Center

Brock, David L.

2000-01-01

Among the many ideas and theories in anatomy and physiology, one particular topic provides all the potential benefits of learning about the human body: the circulatory system, specifically the heart. Describes a distinctive way to study circulation and the heart that allows students to explore the basic principles of vertebrate anatomy and…

Playful and Multi-Sensory Fieldwork: Seeing, Hearing and Touching New York

ERIC Educational Resources Information Center

Phillips, Richard

2015-01-01

Geographical fieldwork is being reinvigorated through pedagogical and methodological innovations. Yet, while there are many good ideas in circulation, there is less evidence of where these ideas are taking us: what students are getting out of them, and what significance they may have for the discipline. These questions are explored through case…

User Perceptions of the "Reliability" of Library Services at Texas A&M University: A Focus Group Study.

ERIC Educational Resources Information Center

Ho, Jeannette; Crowley, Gwyneth H.

2003-01-01

Explored user perceptions of dependability and accuracy of Texas A&M library services through focus groups. Reports user difficulties in locating materials, inaccurate catalog and circulation records, inadequate signage, searching the online catalog, and late notification of interlibrary loan arrivals; and discusses the library's efforts to…

Imagining the Mathematician: Young People Talking about Popular Representations of Maths

ERIC Educational Resources Information Center

Epstein, Debbie; Mendick, Heather; Moreau, Marie-Pierre

2010-01-01

This paper makes both a critical analysis of some popular cultural texts about mathematics and mathematicians, and explores the ways in which young people deploy the discourses produced in these texts. We argue that there are particular (and sometimes contradictory) meanings and discourses about mathematics that circulate in popular culture, that…

Moving Frontiers of Empire: Production, Travel and Transformation through Technologies of Display

ERIC Educational Resources Information Center

Macnab, Natasha; Grosvenor, Ian; Myers, Kevin

2013-01-01

Over the past two decades there has been a growing interest in the exploration of "transnational history". This work has focused in general on understanding the "movement, ebb and circulation" of ideas across borders and in particular on the introduction, transmission, reception and appropriation of ideas through the process of…

All That Is Global Is Not World Culture: Accountability Systems and Educational Apparatuses

ERIC Educational Resources Information Center

Sobe, Noah W.

2015-01-01

This article explores why we see educational accountability systems circulating transnationally. It argues that researchers in the field of comparative and international education need to use the concepts of diffusion and translation to think about the formation, coordination and extension of networks and discursive formations through which…

"Reel Navajo": The Linguistic Creation of Indigenous Screen Memories

ERIC Educational Resources Information Center

Peterson, Leighton C.

2011-01-01

Popular cultures are key sites Philip Deloria has called the "production of expectations," and as a major form of popular culture, film has figured prominently in the circulation and reproduction of expectations about Native American peoples since the early twentieth century. This paper explores the ideologies and practices involved in the process…

Kinetics of Neutrophils in Mice Exposed to Radiation and/or Granulocyte Colony-Stimulating Factor Treatment

PubMed Central

Romero-Weaver, A. L.; Wan, X. S.; Diffenderfer, E. S.; Lin, L.; Kennedy, A. R.

2014-01-01

Astronauts have the potential to develop the hematopoietic syndrome as a result of exposure to radiation from a solar particle event (SPE) during exploration class missions. This syndrome is characterized by a reduction in the number of circulating blood cells (cytopenias). In the present study the effects of SPE-like proton and γ radiation on the kinetics of circulating neutrophils were evaluated during a one-month time period using mice as a model system. The results revealed that exposure to a 2 Gy dose of either SPE-like proton or γ radiation significantly decreased the number of circulating neutrophils, with two nadirs observed on day 4 and day 16 postirradiation. Low circulating neutrophil count (neutropenia) is particularly important because it can increase the risk of astronauts developing infections, which can compromise the success of the mission. Thus, two granulocyte colony-stimulating factors (G-CSFs), filgrastim and pegfilgrastim were evaluated as countermeasures for this endpoint. Both forms of G-CSF significantly increased neutrophil counts in irradiated mice, however, the effect of pegfilgrastim was more potent and lasted longer than filgrastim. Using the expression of CD11b, CD18 and the production of reactive oxygen species (ROS) as markers of neutrophil activation, it was determined that the neutrophils in the irradiated mice treated with pegfilgrastim were physiologically active. Thus, these results suggest that pegfilgrastim could be a potential countermeasure for the reduced number of circulating neutrophils in irradiated animals. PMID:23829559

Quantifying the dose-response relationship between circulating folate concentrations and colorectal cancer in cohort studies: a meta-analysis based on a flexible meta-regression model.

PubMed

Chuang, Shu-Chun; Rota, Matteo; Gunter, Marc J; Zeleniuch-Jacquotte, Anne; Eussen, Simone J P M; Vollset, Stein Emil; Ueland, Per Magne; Norat, Teresa; Ziegler, Regina G; Vineis, Paolo

2013-10-01

Most epidemiologic studies on folate intake suggest that folate may be protective against colorectal cancer, but the results on circulating (plasma or serum) folate are mostly inconclusive. We conducted a meta-analysis of case-control studies nested within prospective studies on circulating folate and colorectal cancer risk by using flexible meta-regression models to test the linear and nonlinear dose-response relationships. A total of 8 publications (10 cohorts, representing 3,477 cases and 7,039 controls) were included in the meta-analysis. The linear and nonlinear models corresponded to relative risks of 0.96 (95% confidence interval (CI): 0.91, 1.02) and 0.99 (95% CI: 0.96, 1.02), respectively, per 10 nmol/L of circulating folate in contrast to the reference value. The pooled relative risks when comparing the highest with the lowest category were 0.80 (95% CI: 0.61, 0.99) for radioimmunoassay and 1.03 (95% CI: 0.83, 1.22) for microbiological assay. Overall, our analyses suggest a null association between circulating folate and colorectal cancer risk. The stronger association for the radioimmunoassay-based studies could reflect differences in cohorts and study designs rather than assay performance. Further investigations need to integrate more accurate measurements and flexible modeling to explore the effects of folate in the presence of genetic, lifestyle, dietary, and hormone-related factors.

Stabilization and Augmentation of Circulating AIM in Mice by Synthesized IgM-Fc

PubMed Central

Kai, Toshihiro; Yamazaki, Tomoko; Arai, Satoko; Miyazaki, Toru

2014-01-01

Owing to rapid and drastic changes in lifestyle and eating habits in modern society, obesity and obesity-associated diseases are among the most important public health problems. Hence, the development of therapeutic approaches to regulate obesity is strongly desired. In view of previous work showing that apoptosis inhibitor of macrophage (AIM) blocks lipid storage in adipocytes, thereby preventing obesity caused by a high-fat diet, we here explored a strategy to augment circulating AIM levels. We synthesized the Fc portion of the soluble human immunoglobulin (Ig)M heavy chain and found that it formed a pentamer containing IgJ as natural IgM does, and effectively associated with AIM in vitro. When we injected the synthesized Fc intravenously into mice lacking circulating IgM, it associated with endogenous mouse AIM, protecting AIM from renal excretion and preserving the circulating AIM levels. As the synthesized Fc lacked the antigen-recognizing variable region, it provoked no undesired immune response. In addition, a challenge with the Fc-human AIM complex in wild-type mice, which exhibited normal levels of circulating IgM and AIM, successfully maintained the levels of the human AIM in mouse blood. We also observed that the human AIM was effectively incorporated into adipocytes in visceral fat tissue, suggesting its functionality against obesity. Thus, our findings reveal potent strategies to safely increase AIM levels, which could form the basis for developing novel therapies for obesity. PMID:24804991

Modeling options to manage type 1 wild poliovirus imported into Israel in 2013.

PubMed

Kalkowska, Dominika A; Duintjer Tebbens, Radboud J; Grotto, Itamar; Shulman, Lester M; Anis, Emilia; Wassilak, Steven G F; Pallansch, Mark A; Thompson, Kimberly M

2015-06-01

After 25 years without poliomyelitis cases caused by circulating wild poliovirus (WPV) in Israel, sewage sampling detected WPV type 1 (WPV1) in April 2013, despite high vaccination coverage with only inactivated poliovirus vaccine (IPV) since 2005. We used a differential equation-based model to simulate the dynamics of poliovirus transmission and population immunity in Israel due to past exposure to WPV and use of oral poliovirus vaccine (OPV) in addition to IPV. We explored the influences of various immunization options to stop imported WPV1 circulation in Israel. We successfully modeled the potential for WPVs to circulate without detected cases in Israel. Maintaining a sequential IPV/OPV schedule instead of switching to an IPV-only schedule in 2005 would have kept population immunity high enough in Israel to prevent WPV1 circulation. The Israeli response to WPV1 detection prevented paralytic cases; a more rapid response might have interrupted transmission more quickly. IPV-based protection alone might not provide sufficient population immunity to prevent poliovirus transmission after an importation. As countries transition to IPV in immunization schedules, they may need to actively manage population immunity and consider continued use of OPV, to avoid the potential circulation of imported live polioviruses before globally coordinated cessation of OPV use. © The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

Genome-wide Integration Study of Circulating miRNAs and Peripheral Whole-Blood mRNAs of Male Acute Ischemic Stroke Patients.

PubMed

Xue, Yang; Yin, Pengqi; Li, Guozhong; Zhong, Di

2018-06-01

Several circulating microRNAs (miRNAs) have been proved to serve as stable biomarkers in blood for acute ischemic stroke (AIS). However, the functions of these biomarkers remain elusive. By conducting the integration analysis of circulating miRNAs and peripheral whole-blood mRNAs using bioinformatics methods, we explored the biological role of these circulating markers in peripheral whole blood at the genome-wide level. Stroke-related circulating miRNA profile data (GSE86291) and peripheral whole-blood mRNA expression data (GSE16561) were collected from the Gene Expression Omnibus (GEO) datasets. We selected male patients to avoid any gender differences in stroke pathology. Male stroke-related miRNAs (M-miRNAs) and mRNAs (M-mRNAs) were detected using GEO2R. Nine M-miRNAs (five up- and four down-regulated) were applied to TargetScan to predict the possible target mRNAs. Next, we intersected these targets with the M-mRNAs (38 up- and three down-regulated) to obtain the male stroke-related overlapped mRNAs (Mo-mRNAs). Finally, we analyzed biological functions of Mo-mRNAs using the Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG), and constructed networks among the Mo-mRNAs, overlapped M-miRNAs (Mo-miRNAs), and their functions. The Mo-mRNAs were enriched in functions such as platelet degranulation, immune response, and pathways associated with phagosome biology and Staphylococcus aureus infection. This study provides an integrated view of interactions among circulating miRNAs and peripheral whole-blood mRNAs involved in the pathophysiological processes of male AIS. Copyright © 2018 IBRO. Published by Elsevier Ltd. All rights reserved.

Association between circulating irisin and insulin resistance in non-diabetic adults: A meta-analysis.

PubMed

Qiu, Shanhu; Cai, Xue; Yin, Han; Zügel, Martina; Sun, Zilin; Steinacker, Jürgen Michael; Schumann, Uwe

2016-06-01

Exogenous administration of recombinant irisin improves glucose metabolism. However, the association of endogenous circulating (plasma/serum) irisin with insulin resistance remains poorly delineated. This study was aimed to examine this association by meta-analyzing the current evidence without study design restriction in non-diabetic adults. Peer-reviewed studies written in English from 3 databases were searched to December 2015. Studies that reported the association between circulating irisin and insulin resistance (or its reverse, insulin sensitivity) in non-diabetic non-pregnant adults (mean ages ≥18years) were included. The pooled correlation coefficient (r) and 95% confidence intervals (CIs) were calculated using a random-effects model. Subgroup analyses and meta-regression were performed to explore potential sources of heterogeneity. Of the 195 identified publications, 17 studies from 15 articles enrolling 1912 participants reported the association between circulating irisin and insulin resistance. The pooled effect size was 0.15 (95% CI: 0.07 to 0.22) with a substantial heterogeneity (I(2)=55.5%). This association seemed to be modified by glycemic status (fasting blood glucose ≥6.1mmol/L versus <6.1mmol/L) and racial-ethnic difference (Asians versus Europeans versus Americans), but not by sex difference, sampling time-point, blood sample type, ELISA kits used, baseline age, or body mass index. Circulating irisin was inversely associated with insulin sensitivity (6 studies; r=-0.17, 95% CI: -0.25 to -0.09). Circulating irisin is directly and positively associated with insulin resistance in non-diabetic adults. However, this association is rather small and requires further clarification, in particular by well-designed large epidemiological studies with overall, race-, and sex-specific analyses. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

Searching for Abrupt Circulation Shifts in Marine Isotope Stage 2 and 3

NASA Astrophysics Data System (ADS)

Henry, L. E.; Lynch-Stieglitz, J.; Schmidt, M. W.

2008-12-01

During Marine Isotope Stage 3, DO events were recorded in the Greenland ice cores and North Atlantic Ocean sediment records. Some cold DO stadials have been associated with massive freshwater inputs, termed Heinrich Events. These Heinrich Events are frequently associated with "drop dead" circulation periods in which the production of North Atlantic Deep Water is greatly diminished. DO events are thought to result from a restructuring of the overturning circulation. We explore these proposed changes in Atlantic Ocean circulation by examining changes in seawater density in the Florida Straits. The density is inferred from the δ18O of the benthic foraminifera C. pachyderma and P. ariminensis taken from core-sites on the Florida and Greater Bahamas Bank margins. The flow through the Florida Straits is in near- geostrophic balance. This means that the vertical shear in the current is reflected in a strong density gradient across the Straits. During the Younger Dryas and the Last Glacial Maximum the density gradient was reduced consistent with weaker flow through the Straits at these times. A weakening of the Florida Current would be expected if the large scale Atlantic Meridional Overturning Circulation weakened, as has been proposed based on other studies. The Younger Dyras event manifests itself as well-correlated decreases in δ18O from the cores on the Florida margin, while their counterparts taken from the Bahamas remain relatively stable when adjusted for global ice volume. Here, we will present data extending back 32kyr, focusing on those cores taken from the Florida Margin which can resolve millennial scale changes during Marine Isotope Stage 2 and Late Stage 3. We will examine the relationship between circulation changes, as reflected in Florida Margin density, and the three most recent Heinrich events, as well as the most recent DO events.

Observations of the summer Red Sea circulation

NASA Astrophysics Data System (ADS)

Sofianos, Sarantis S.; Johns, William E.

2007-06-01

Aiming at exploring and understanding the summer circulation in the Red Sea, a cruise was conducted in the basin during the summer of 2001 involving hydrographic, meteorological, and direct current observations. The most prominent feature, characteristic of the summer circulation and exchange with the Indian Ocean, is a temperature, salinity, and oxygen minimum located around a depth of 75 m at the southern end of the basin, associated with Gulf of Aden Intermediate Water inflowing from the Gulf of Aden during the summer season as an intruding subsurface layer. Stirring and mixing with ambient waters lead to marked increases in temperature (from 16.5 to almost 33°C) and salinity (from 35.7 to more than 38 psu) in this layer by the time it reaches midbasin. The observed circulation presents a very vigorous pattern with strong variability and intense features that extend the width of the basin. A permanent cyclone, detected in the northern Red Sea, verifies previous observations and modeling studies, while in the central sector of the basin a series of very strong anticyclones were observed with maximum velocities exceeding 1 m/s. The three-layer flow pattern, representative of the summer exchange between the Red Sea and the Gulf of Aden, is observed in the strait of Bab el Mandeb. In the southern part of the basin the layer flow is characterized by strong banking of the inflows and outflows against the coasts. Both surface and intermediate water masses involved in the summer Red Sea circulation present prominent spatial variability in their characteristics, indicating that the eddy field and mixing processes play an important role in the summer Red Sea circulation.

Change in circulating microRNA profile of obese children indicates future risk of adult diabetes.

PubMed

Cui, Xianwei; You, Lianghui; Zhu, Lijun; Wang, Xing; Zhou, Yahui; Li, Yun; Wen, Juan; Xia, Yankai; Wang, Xinru; Ji, Chenbo; Guo, Xirong

2018-01-01

Childhood obesity increases susceptibility to type 2 diabetes (T2D) in adults. Circulating microRNAs (miRNAs) in serum have been proposed as potential diagnostic biomarkers, and they may contribute to the progression toward T2D. Here, we investigated the possibility of predicting the future risk of adult T2D in obese children by using circulating miRNAs. We performed miRNA high-throughput sequencing to screen relevant circulating miRNAs in obese children. The expression patterns of targeted miRNAs were further explored in obese children and adults with T2D. To investigate the underlying contributions of these miRNAs to the development of T2D, we detected the impacts of the candidate miRNAs on preadipocyte proliferation, insulin secretion by pancreatic β-cell, and glucose uptake by skeletal muscle cells. Three miRNAs (miR-486, miR-146b and miR-15b), whose expression in the circulation was most dramatically augmented in obese children and adult T2D patients, were selected for further investigation. Of these 3 miRNAs, miR-486 was implicated in accelerating preadipocyte proliferation and myotube glucose intolerance, miR-146b and miR-15b were engaged in the suppression of high concentration glucose-induced pancreatic insulin secretion, and they all contributed to the pathological processes of obesity and T2D. Our results provide a better understanding of the role of circulating miRNAs, particularly miR-486, miR-146b and miR-15b, in predicting the future risk of T2D in obese children. Copyright © 2017 The Author(s). Published by Elsevier Inc. All rights reserved.

Investigating the Relationships Between Alcohol Consumption, Cannabis Use, and Circulating Cytokines: A Preliminary Analysis.

PubMed

Karoly, Hollis C; Bidwell, L Cinnamon; Mueller, Raeghan L; Hutchison, Kent E

2018-03-01

In recent years, human and animal studies have converged to support altered inflammatory signaling as a molecular mechanism underlying the pathophysiology of alcohol use disorders (AUDs). Alcohol binds to receptors on immune cells, triggering signaling pathways that produce pro-inflammatory cytokines. Chronic inflammation is associated with tissue damage, which may contribute to negative effects of AUD. Conversely, cannabis is associated with decreased inflammatory signaling, and animal studies suggest that cannabinoids may impact alcohol-induced inflammation. Thus, the impact of cannabis on inflammation in AUDs in humans warrants examination. We explored the relationship between self-reported alcohol and cannabis use and circulating levels of the pro-inflammatory cytokines interleukin 6 (IL-6), IL-8, and IL-1β in the blood. Among 66 regular drinkers (mean age = 30.08), we examined circulating cytokines and administered questionnaires assessing alcohol consumption and days of cannabis use over the past 90 days. We examined whether alcohol consumption, cannabis use, and gender were associated with changes in circulating cytokines, and whether there was a significant interaction between alcohol and cannabis use predicting blood levels of circulating cytokines. A positive association between alcohol and IL-6 emerged. We also observed a negative association between cannabis and IL-1β. Follow-up moderation analyses indicated a cannabis by alcohol interaction predicting circulating IL-6, such that cannabis nonusers showed a stronger relationship between alcohol and IL-6 compared to cannabis users. These preliminary findings suggest that cannabinoid compounds may serve to mitigate inflammation associated with alcohol use. In addition, the present results provide data to inform future investigations, with the goal of ultimately leveraging knowledge of the role of inflammation in AUDs to develop more effective treatments focused on novel immune targets. Copyright © 2017 by the Research Society on Alcoholism.

Tsunami Ionospheric warning and Ionospheric seismology

NASA Astrophysics Data System (ADS)

Lognonne, Philippe; Rolland, Lucie; Rakoto, Virgile; Coisson, Pierdavide; Occhipinti, Giovanni; Larmat, Carene; Walwer, Damien; Astafyeva, Elvira; Hebert, Helene; Okal, Emile; Makela, Jonathan

2014-05-01

The last decade demonstrated that seismic waves and tsunamis are coupled to the ionosphere. Observations of Total Electron Content (TEC) and airglow perturbations of unique quality and amplitude were made during the Tohoku, 2011 giant Japan quake, and observations of much lower tsunamis down to a few cm in sea uplift are now routinely done, including for the Kuril 2006, Samoa 2009, Chili 2010, Haida Gwai 2012 tsunamis. This new branch of seismology is now mature enough to tackle the new challenge associated to the inversion of these data, with either the goal to provide from these data maps or profile of the earth surface vertical displacement (and therefore crucial information for tsunami warning system) or inversion, with ground and ionospheric data set, of the various parameters (atmospheric sound speed, viscosity, collision frequencies) controlling the coupling between the surface, lower atmosphere and the ionosphere. We first present the state of the art in the modeling of the tsunami-atmospheric coupling, including in terms of slight perturbation in the tsunami phase and group velocity and dependance of the coupling strength with local time, ocean depth and season. We then show the confrontation of modelled signals with observations. For tsunami, this is made with the different type of measurement having proven ionospheric tsunami detection over the last 5 years (ground and space GPS, Airglow), while we focus on GPS and GOCE observation for seismic waves. These observation systems allowed to track the propagation of the signal from the ground (with GPS and seismometers) to the neutral atmosphere (with infrasound sensors and GOCE drag measurement) to the ionosphere (with GPS TEC and airglow among other ionospheric sounding techniques). Modelling with different techniques (normal modes, spectral element methods, finite differences) are used and shown. While the fits of the waveform are generally very good, we analyse the differences and draw direction of future studies and improvements, enabling the integration of lateral variations of the solid earth, bathymetry or atmosphere, finite model sources, non-linearity of the waves and better attenuation and coupling processes. All these effects are revealed by phase or amplitude discrepancies in selected observations. We then present goals and first results of source inversions, with a focus on estimations of the sea level uplift location and amplitude, either by using GPS networks close from the epicentre or, for tsunamis, GPS of the Hawaii Islands.

Gravity field models from kinematic orbits of CHAMP, GRACE and GOCE satellites

NASA Astrophysics Data System (ADS)

Bezděk, Aleš; Sebera, Josef; Klokočník, Jaroslav; Kostelecký, Jan

2014-02-01

The aim of our work is to generate Earth's gravity field models from GPS positions of low Earth orbiters. Our inversion method is based on Newton's second law, which relates the observed acceleration of the satellite with forces acting on it. The observed acceleration is obtained as numerical second derivative of kinematic positions. Observation equations are formulated using the gradient of the spherical harmonic expansion of the geopotential. Other forces are either modelled (lunisolar perturbations, tides) or provided by onboard measurements (nongravitational perturbations). From this linear regression model the geopotential harmonic coefficients are obtained. To this basic scheme of the acceleration approach we added some original elements, which may be useful in other inversion techniques as well. We tried to develop simple, straightforward and still statistically correct model of observations. (i) The model is linear in the harmonic coefficients, no a priori gravity field model is needed, no regularization is applied. (ii) We use the generalized least squares to successfully mitigate the strong amplification of noise due to numerical second derivative. (iii) The number of other fitted parameters is very small, in fact we use only daily biases, thus we can monitor their behaviour. (iv) GPS positions have correlated errors. The sample autocorrelation function and especially the partial autocorrelation function indicate suitability of an autoregressive model to represent the correlation structure. The decorrelation of residuals improved the accuracy of harmonic coefficients by a factor of 2-3. (v) We found it better to compute separate solutions in the three local reference frame directions than to compute them together at the same time; having obtained separate solutions for along-track, cross-track and radial components, we combine them using the normal matrices. Relative contribution of the along-track component to the combined solution is 50 percent on average. (vi) The computations were performed on an ordinary PC up to maximum degree and order 120. We applied the presented method to orbits of CHAMP and GRACE spanning seven years (2003-2009) and to two months of GOCE (Nov/Dec 2009). The obtained long-term static gravity field models are of similar or better quality compared to other published solutions. We also tried to extract the time-variable gravity signal from CHAMP and GRACE orbits. The acquired average annual signal shows clearly the continental areas with important and known hydrological variations.

Associations of ACE Gene Insertion/Deletion Polymorphism, ACE Activity, and ACE mRNA Expression with Hypertension in a Chinese Population

PubMed Central

He, Qingfang; Fan, Chunhong; Yu, Min; Wallar, Gina; Zhang, Zuo-Feng; Wang, Lixin; Zhang, Xinwei; Hu, Ruying

2013-01-01

Background The present study was designed to explore the association of angiotensin converting enzyme (ACE) gene insertion/deletion (I/D, rs4646994) polymorphism, plasma ACE activity, and circulating ACE mRNA expression with essential hypertension (EH) in a Chinese population. In addition, a new detection method for circulating ACE mRNA expression was explored. Methods The research was approved by the ethics committee of Zhejiang Provincial Center for Disease Prevention and Control. Written informed consent was obtained prior to the investigation. 221 hypertensives (cases) and 221 normotensives (controls) were interviewed, subjected to a physical examination, and provided blood for biochemical and genetic tests. The ACE mRNA expression was analyzed by real time fluorescent quantitative Reverse Transcription PCR (FQ-RT-PCR). We performed logistic regression to assess associations of ACE I/D genotypes, ACE activity, and ACE mRNA expression levels with hypertension. Results The results of the multivariate logistic regression analysis showed that the additive model (ID, DD versus II) of the ACE genotype revealed an association with hypertension with adjusted OR of 1.43(95% CI: 1.04-1.97), and ACE ID genotype with adjusted OR of 1.72(95% CI: 1.01-2.92), DD genotype with adjusted OR of 1.94(95% CI: 1.01-3.73), respectively. In addition, our data also indicate that plasma ACE activity (adjusted OR was 1.13(95% CI: 1.08-1.18)) was significantly related to hypertension. However, the plasma ACE mRNA expressions were not different between the cases and controls. Conclusion ACE I/D polymorphism and ACE activity revealed significant influence on hypertension, while circulating ACE mRNA expression was not important factors associated with hypertension in this Chinese population. The detection of circulating ACE mRNA expression by FQ-RT-PCR might be a useful method for early screening and monitoring of EH. PMID:24098401

Elevated circulating irisin is associated with lower risk of insulin resistance: association and path analyses of obese Chinese adults.

PubMed

Shi, Xiulin; Lin, Mingzhu; Liu, Changqin; Xiao, Fangsen; Liu, Yongwen; Huang, Peiying; Zeng, Xin; Yan, Bing; Liu, Suhuan; Li, Xiaoying; Yang, Shuyu; Li, Xuejun; Li, Zhibin

2016-07-29

Evidence on the role of irisin in insulin resistance is limited and controversial, and pathways between them remain unknown. We aimed to examine the independent effects of circulating irisin and different adiposity measurements, as well as their potential interactions, on insulin resistance. We also aimed to explore possible pathways among circulating irisin, adiposity, glucose and insulin levels and insulin resistance. A cross-sectional study of 1,115 community- living obese Chinese adults, with data collection on clinical characteristics, glucose and lipid metabolic parameters and circulating irisin levels. Among the 1,115 subjects, 667 (59.8 %) were identified as insulin-resistance, and showed significantly decreased serum irisin than their controls (log-transformed irisin: 1.19 ± 2.34 v.s. 1.46 ± 2.05 ng/ml, p = 0.042). With adjustment for potential confounders, elevated circulating irisin was significantly associated with reduced risk of insulin resistance, with adjusted odds ratio per standard deviation increase of irisin of 0.871 (0.765-0.991, p = 0.036). As for different adiposity measurements, body fat percentage, but neither BMI nor waist, was significantly associated with increased risk of insulin resistance (OR: 1.152 (1.041-1.275), p = 0.006). No significant interaction effect between serum irisin and adiposity on insulin resistance was found. A one pathway model about the relationship between serum irisin and insulin resistance fits well (χ (2) = 44.09, p < 0.001; CFI-0.994; TLI =0.986; and RMSEA = 0.067), and shows that elevated circulating irisin might improve insulin resistance indirectly through lowering fasting insulin levels (standardized path coefficient = -0.046, p = 0.032). Elevated circulating irisin is associated with lower risk of insulin resistance indirectly through lowering fasting insulin.

A Lower Olfactory Capacity Is Related to Higher Circulating Concentrations of Endocannabinoid 2-Arachidonoylglycerol and Higher Body Mass Index in Women.

PubMed

Pastor, Antoni; Fernández-Aranda, Fernando; Fitó, Montserrat; Jiménez-Murcia, Susana; Botella, Cristina; Fernández-Real, Jose M; Frühbeck, Gema; Tinahones, Francisco J; Fagundo, Ana B; Rodriguez, Joan; Agüera, Zaida; Langohr, Klaus; Casanueva, Felipe F; de la Torre, Rafael

2016-01-01

The endocannabinoid (eCB) system can promote food intake by increasing odor detection in mice. The eCB system is over-active in human obesity. Our aim is to measure circulating eCB concentrations and olfactory capacity in a human sample that includes people with obesity and explore the possible interaction between olfaction, obesity and the eCB system. The study sample was made up of 161 females with five groups of body mass index sub-categories ranging from under-weight to morbidly obese. We assessed olfactory capacity with the "Sniffin´Sticks" test, which measures olfactory threshold-discrimination-identification (TDI) capacity. We measured plasma concentrations of the eCBs 2-arachidonoylglycerol (2-AG) and N-arachidonoylethanolamine or anandamide (AEA), and several eCB-related compounds, 2-acylglycerols and N-acylethanolamines. 2-AG and other 2-acylglycerols fasting plasma circulating plasma concentrations were higher in obese and morbidly obese subjects. AEA and other N-acylethanolamine circulating concentrations were lower in under-weight subjects. Olfactory TDI scores were lower in obese and morbidly obese subjects. Lower TDI scores were independently associated with higher 2-AG fasting plasma circulating concentrations, higher %body fat, and higher body mass index, after controlling for age, smoking, menstruation, and use of contraceptives. Our results show that obese subjects have a lower olfactory capacity than non-obese ones and that elevated fasting plasma circulating 2-AG concentrations in obesity are linked to a lower olfactory capacity. In agreement with previous studies we show that eCBs AEA and 2-AG, and their respective congeners have a distinct profile in relation to body mass index. The present report is the first study in humans in which olfactory capacity and circulating eCB concentrations have been measured in the same subjects.

The influence of placental metabolism on fatty acid transfer to the fetus[S

PubMed Central

Perazzolo, Simone; Hirschmugl, Birgit; Wadsack, Christian; Desoye, Gernot; Lewis, Rohan M.; Sengers, Bram G.

2017-01-01

The factors determining fatty acid transfer across the placenta are not fully understood. This study used a combined experimental and computational modeling approach to explore placental transfer of nonesterified fatty acids and identify the rate-determining processes. Isolated perfused human placenta was used to study the uptake and transfer of 13C-fatty acids and the release of endogenous fatty acids. Only 6.2 ± 0.8% of the maternal 13C-fatty acids taken up by the placenta was delivered to the fetal circulation. Of the unlabeled fatty acids released from endogenous lipid pools, 78 ± 5% was recovered in the maternal circulation and 22 ± 5% in the fetal circulation. Computational modeling indicated that fatty acid metabolism was necessary to explain the discrepancy between uptake and delivery of 13C-fatty acids. Without metabolism, the model overpredicts the fetal delivery of 13C-fatty acids 15-fold. Metabolic rate was predicted to be the main determinant of uptake from the maternal circulation. The microvillous membrane had a greater fatty acid transport capacity than the basal membrane. This study suggests that incorporation of fatty acids into placental lipid pools may modulate their transfer to the fetus. Future work needs to focus on the factors regulating fatty acid incorporation into lipid pools. PMID:27913585

Volcanism, global catastrophe and mass mortality

NASA Technical Reports Server (NTRS)

Francis, P. W.; Burke, K.

1988-01-01

The effects of very large volcanic eruptions are well documented in many studies, mostly based on observations made on three historic eruptions, Laki 1783; Tambora 1815 and Krakatau 1883. Such eruptions have effects that are catastrophic locally and measurable globally, but it is not clear that even the largest volcanic eruptions have had global catastrophic effects, nor caused mass extinctions. Two different types of volcanic eruption were considered as likely to have the most serious widespread effects: large silicic explosive eruptions producing hundreds or thousands of cubic kilometers of pyroclastic materials, and effusive basaltic eruptions producing of approximately 100 cubic kilometers of lava. In both cases, the global effects are climatic, and attributable to production of stratospheric aerosols. Other possibilities need to be explored. Recent research on global change has emphasized the extreme sensitivity of the links between oceanic circulation, atmospheric circulation and climate. In particular, it was argued that the pattern of ocean current circulation (which strongly influences climate) is unstable; it may rapidly flip from one pattern to a different one, with global climatic consequences. If volcanism has been a factor in global environmental change and a cause of mass extinctions, it seems most likely that it has done so by providing a trigger to other processes, for example by driving oceanic circulation from one mode to another.

The Effect of Omega-3 on Circulating Adiponectin in Adults with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

PubMed

Bahreini, Mehdi; Ramezani, Amir-Hossein; Shishehbor, Farideh; Mansoori, Anahita

2018-01-04

Whether consumption of omega-3 affects circulating adiponectin has not been established. The objective of this study was to evaluate the effect of omega-3 (food or supplement) on circulating adiponectin in patients with type 2 diabetes through a systematic review of meta-analyses of randomized controlled trials. PubMed, Scopus and Web of Science were searched for relevant studies through May 2016. Two researchers screened and abstracted the literature independently. Pooled estimates were obtained using the random-effects models. Overall, omega-3 increased adiponectin by 0.57 µg/mL (95% confidence interval [CI] 0.15 to 1.31; p=0.01, I-square=74.2% p for heterogeneity <0.001). The source of observed heterogeneity was explored by subgroup analyses. In subgroup analyses, adiponectin levels increased only in those who had consumed omega-3 for more than 8 weeks. This systematic review and meta-analysis of randomized, placebo-controlled clinical trials suggests that omega-3 in patients with type 2 diabetes increases circulating adiponectin. These findings support the potentially beneficial effects of dietary omega-3 in patients with type 2 diabetes on pathways related to adiponectin metabolism. Copyright © 2017 Diabetes Canada. Published by Elsevier Inc. All rights reserved.

In vivo Raman flow cytometry for real-time detection of carbon nanotube kinetics in lymph, blood, and tissues

PubMed Central

Biris, Alexandru S.; Galanzha, Ekaterina I.; Li, Zhongrui; Mahmood, Meena; Xu, Yang; Zharov, Vladimir P.

2016-01-01

Nanoparticles are intensively being explored as contrast agents for medical diagnostics and therapies using various optical methods. We present the first demonstration of the use of time-resolved Raman spectroscopy for in vivo real-time detection of circulating carbon nanotubes (CNTs) or cancer cells labeled with CNTs in the lymph, blood, and tissues of live animals with fast spectral acquisition times of down to few milliseconds. After intravenously administering CNTs in the tail vein of the rat, this technique provides the ability to detect the circulation of CNTs in the blood microvessels of the intact rat ear. The capability of Raman spectroscopy is also demonstrated to monitor, identify, and image the CNTs during their transportation by lymphatics in the rat ear and mesentery. The strong and specific Raman scattering properties of CNTs make it possible to detect in vitro and in vivo single cancer cells (HeLa) tagged with CNTs. In vivo Raman flow cytometry opens a new avenue for multiparameter analysis of circulating nanoparticles with strong Raman scattering properties and their pharmokinetics in blood and lymph systems. Moreover, this technology has the potential for molecular detection and identification of circulating tumor cells, and infections labeled with CNTs. PMID:19405719

Association of serum uric acid with high-sensitivity C-reactive protein in postmenopausal women.

PubMed

Raeisi, A; Ostovar, A; Vahdat, K; Rezaei, P; Darabi, H; Moshtaghi, D; Nabipour, I

2017-02-01

To explore the independent correlation between serum uric acid and low-grade inflammation (measured by high-sensitivity C-reactive protein, hs-CRP) in postmenopausal women. A total of 378 healthy Iranian postmenopausal women were randomly selected in a population-based study. Circulating hs-CRP levels were measured by highly specific enzyme-linked immunosorbent assay method and an enzymatic calorimetric method was used to measure serum levels of uric acid. Pearson correlation coefficient, multiple linear regression and logistic regression models were used to analyze the association between uric acid and hs-CRP levels. A statistically significant correlation was seen between serum levels of uric acid and log-transformed circulating hs-CRP (r = 0.25, p < 0.001). After adjustment for age and cardiovascular risk factors (according to NCEP ATP III criteria), circulating hs-CRP levels were significantly associated with serum uric acid levels (β = 0.20, p < 0.001). After adjustment for age and cardiovascular risk factors, hs-CRP levels ≥3 mg/l were significantly associated with higher uric acid levels (odds ratio =1.52, 95% confidence interval 1.18-1.96). Higher serum uric acid levels were positively and independently associated with circulating hs-CRP in healthy postmenopausal women.

Scaling and Numerical Model Evaluation of Snow-Cover Effects on the Generation and Modification of Daytime Mesoscale Circulations.

NASA Astrophysics Data System (ADS)

Segal, M.; Garratt, J. R.; Pielke, R. A.; Ye, Z.

1991-04-01

Consideration of the sensible heat flux characteristics over a snow surface suggests a significant diminution in the magnitude of the flux, compared to that over a snow-free surface under the same environmental conditions. Consequently, the existence of snow-covered mesoscale areas adjacent to snow-free areas produces horizontal thermal gradients in the lower atmosphere during the daytime, possibly resulting in a `snow breeze.' In addition, suppression of the daytime thermally induced upslope flow over snow-covered slopes is likely to occur. The present paper provides scaling and modeling evaluations of these situations, with quantification of the generated and modified circulations. These evaluations suggest that under ideal situations involved with uniform snow cover over large areas, particularly in late winter and early spring, a noticeable `snow breeze' is likely to develop. Additionally: suppression of the daytime thermally induced upslope flow is significant and may even result in a daytime drainage flow. The effects of bare ground patchiness in the snow cover on these circulations are also explored, both for flat terrain and slope-flow situations. A patchiness fraction greater than 0.5 is found to result in a noticeably reduced snow-breeze circulation, while a patchiness fraction of only 0.1 caused the simulated daytime drainage flow over slopes to he reversed.

The Effect of Particle Size on the Biodistribution of Low-modulus Hydrogel PRINT Particles

PubMed Central

Merkel, Timothy J.; Chen, Kai; Jones, Stephen W.; Pandya, Ashish A.; Tian, Shaomin; Napier, Mary E.; Zamboni, William E.; DeSimone, Joseph M.

2012-01-01

There is a growing recognition that the deformability of particles used for drug delivery plays a significant role on their biodistribution and circulation profile. Understanding these effects would provide a crucial tool for the rational design of drug delivery systems. While particles resembling red blood cells (RBCs) in size, shape and deformability have extended circulation times and altered biodistribution profiles compared to rigid, but otherwise similar particles, the in vivo behavior of such highly deformable particles of varied size has not been explored. We report the fabrication of a series of discoid, monodisperse, low-modulus hydrogel particles with diameters ranging from 0.8 to 8.9 μm, spanning sizes smaller than and larger than RBCs. We injected these particles into healthy mice, and tracked their concentration in the blood and their distribution into major organs. These deformable particles all demonstrated some hold up in filtration tissues like the lungs and spleen, followed by release back into the circulation, characterized by decreases in particles in these tissues with concomitant increases in particle concentration in blood. Particles similar to red blood cells in size demonstrated longer circulation times, suggesting that this size and shape of deformable particle is uniquely suited to avoid clearance. PMID:22705460

In vivo Raman flow cytometry for real-time detection of carbon nanotube kinetics in lymph, blood, and tissues

NASA Astrophysics Data System (ADS)

Biris, Alexandru S.; Galanzha, Ekaterina I.; Li, Zhongrui; Mahmood, Meena; Xu, Yang; Zharov, Vladimir P.

2009-03-01

Nanoparticles are intensively being explored as contrast agents for medical diagnostics and therapies using various optical methods. We present the first demonstration of the use of time-resolved Raman spectroscopy for in vivo real-time detection of circulating carbon nanotubes (CNTs) or cancer cells labeled with CNTs in the lymph, blood, and tissues of live animals with fast spectral acquisition times of down to few milliseconds. After intravenously administering CNTs in the tail vein of the rat, this technique provides the ability to detect the circulation of CNTs in the blood microvessels of the intact rat ear. The capability of Raman spectroscopy is also demonstrated to monitor, identify, and image the CNTs during their transportation by lymphatics in the rat ear and mesentery. The strong and specific Raman scattering properties of CNTs make it possible to detect in vitro and in vivo single cancer cells (HeLa) tagged with CNTs. In vivo Raman flow cytometry opens a new avenue for multiparameter analysis of circulating nanoparticles with strong Raman scattering properties and their pharmokinetics in blood and lymph systems. Moreover, this technology has the potential for molecular detection and identification of circulating tumor cells, and infections labeled with CNTs.

On the role of inter-basin surface salinity contrasts in global ocean circulation

NASA Astrophysics Data System (ADS)

Seidov, D.; Haupt, B. J.

2002-08-01

The role of sea surface salinity (SSS) contrasts in maintaining vigorous global ocean thermohaline circulation (TOC) is revisited. Relative importance of different generalizations of sea surface conditions in climate studies is explored. Ocean-wide inter-basin SSS contrasts serve as the major controlling element in global TOC. These contrasts are shown to be at least as important as high-latitudinal freshwater impacts. It is also shown that intra-basin longitudinal distribution of sea surface salinity, as well as intra- and inter-basin longitudinal distribution of sea surface temperature, is not crucial to conveyor functionality if only inter-basin contrasts in sea surface salinity are retained. This is especially important for paleoclimate and future climate simulations.

Understanding Atmospheric Anomalies Associated With Seasonal Pluvial-Drought Processes Using Southwest China as an Example

NASA Astrophysics Data System (ADS)

Liu, Zhenchen; Lu, Guihua; He, Hai; Wu, Zhiyong; He, Jian

2017-11-01

Seasonal pluvial-drought transition processes are unique natural phenomena. To explore possible mechanisms, we considered Southwest China (SWC) as the study region and comprehensively investigated the temporal evolution or spatial patterns of large-scale and regional atmospheric variables with the simple method of Standardized Anomalies (SA). Some key procedures and results include the following: (1) Because regional atmospheric variables are more directly responsible for the transition processes, we investigate it in detail. The temporal evolution of net vertical integral water vapor flux (net VIWVF) across SWC, together with vertical SA-based patterns of regional horizontal divergence (D) and vertical motion (ω), coincides well with pluvial-drought transition processes. (2) With respect to large-scale circulation patterns, a well-organized Eurasian (EU) Pattern is one important feature during the pluvial-drought transitions over SWC. (3) Based on these large-scale and regional atmospheric anomalous features, relevant SA-based indices were built, to explore the possibility of simulating drought development using previous pluvial anomalies. As a whole, simulated drought development only with SA-based indices of large-scale circulation patterns does not perform well. Further, it can be improved a lot when SA-based indices of regional D and net VIWVF are introduced. (4) In addition, the potential drought prediction using pluvial anomalies, together with the deep understanding of physical mechanisms responsible for pluvial-drought transitions, need to be further explored.

The Politics of Curriculum Review and Revision in South Africa in Regional Context

ERIC Educational Resources Information Center

Chisholm, Linda

2005-01-01

This article takes the case of the South African curriculum to examine the role of national politics and power relationships in giving internationally borrowed ideas their meaning and shape. It discusses the circulation of ideas between global, national and regional levels. In exploring the particular dynamics shaping the South African curriculum,…

Peer Review in Academic Promotion and Publishing: Its Meaning, Locus, and Future

ERIC Educational Resources Information Center

Harley, Diane; Acord, Sophia Krzys; Earl-Novell, Sarah

2010-01-01

As part of its Andrew W. Mellon Foundation-funded Future of Scholarly Communication Project, the Center for Studies in Higher Education (CSHE) has hosted two meetings to explore how peer review relates to scholarly communication and academic values. In preparation for an April 2010 workshop, four working papers were developed and circulated. They…

Kissing Brides and Loving Hot Vampires: Children's Construction and Perpetuation of Heteronormativity in Elementary School Classrooms

ERIC Educational Resources Information Center

Ryan, Caitlin L.

2016-01-01

This paper explores notions of (hetero)sexuality circulating in elementary school classrooms through an analysis of students' own talk and interactions. Data collected during a multi-site ethnography in a diverse set of elementary schools demonstrate that while curricular silences and teachers contribute to heteronormative classroom environments,…

A Comparative Study on Pre-Service Teachers' and Elementary Students' Attitudes towards the Environment

ERIC Educational Resources Information Center

Tuncer, Gaye; Sungur, Semra; Tekkaya, Ceren; Ertepinar, Hamide

2007-01-01

The purpose of the present study was to assess Turkish elementary school students' and pre-service teachers' environmental attitudes, and to explore whether there was a significant difference in the attitudes towards the environment of the above mentioned two groups. Data was gathered by circulating a 45-item "Environmental Attitude…

The Evaluation Turn in the Higher Education System: Lessons from Italy

ERIC Educational Resources Information Center

Lumino, Rosaria; Gambardella, Dora; Grimaldi, Emiliano

2017-01-01

This article explores how new public management policy ideas and technologies circulating in the globalised education space have been re-contextualised in the re-design of the Italian Higher Education System. In doing so, it uses the governmentality studies as a sensitising framework to problematise what we term here as the "calculative and…

It Takes More than Two to (Multispecies) Tango: Queering Gender Texts in Environmental Education

ERIC Educational Resources Information Center

Adsit-Morris, Chessa; Gough, Noel

2017-01-01

Using the figuration of queer tango, we conceive this essay as a performance that responds to three "Canadian Journal of Environmental Education" articles, each of which calls for the creation and circulation of more queer scholarship in environmental education. We explore Vagle's (2015) suggestion of working along the edges and margins…

A Study on Planetary Atmospheric Circulations using THOR

NASA Astrophysics Data System (ADS)

Mendonça, João; Grosheintz, Luc; Lukas Grimm, Simon; Heng, Kevin

2015-12-01

The large variety of planetary parameters observed leads us to think that exoplanets may show a large range of possible climates. It is therefore of the uttermost importance to investigate the influence of astronomical and planetary bulk parameters in driving the atmospheric circulations. In the solar system the results from planetary spacecraft missions have demonstrated how different the planetary climate and atmospheric circulations can be. The study of exoplanets will require probing a far wider range of physical and orbital parameters than the ones of our neighbor planets. For this reason, such a study will involve exploring an even larger diversity of circulation and climate regimes. Our new atmospheric model, THOR, is intended to be extremely flexible and to explore the large diversity of planetary atmospheres.THOR is part of the Exoclimes Simulation Platform, and is a project of the Exoplanet and Exoclimes Group (see www.exoclime.org). THOR solves the complex atmospheric fluid equations in a rotating sphere (fully compressible - nonhydrostatic system) using an icosahedral grid. The main advantages of using our new platform against other recent exoplanet models is that 1) The atmospheric fluid equations are completely represented and no approximations are used that could compromise the physics of the problem; 2) The model uses for the first time in exoplanet studies, a specific icosahedral grid that solves the pole problem; 3) The interface is user friendly and can be easily adapted to a multitude of atmospheric conditions; 4) By using GPU computation, our code greatly improves the typical code running time.We will present and discuss the first detailed results of our simulations, more specifically of two benchmark tests that are a representative sample of the large range of exoplanetary parameters: Earth-like conditions (the Held-Suarez test) and a tidally locked hot-Jupiter. THOR has successfully passed these tests and is able to determine the main mechanisms driving the circulation in the simulated planets. From the 3D numerical simulations we found that some hot-Jupiters atmospheres can sustain multiple dynamical steady states. The results also suggest the presence of a new mechanism that transports heat from the upper to the lower atmosphere. The presence and impact of this mechanism in the global temperature will be discussed in this presentation.

Magnetotelluric Studies for Hydrocarbon and Geothermal Resources: Examples from the Asian Region

NASA Astrophysics Data System (ADS)

Patro, Prasanta K.

2017-09-01

Magnetotellurics (MT) and the other related electrical and electromagnetic methods play a very useful role in resource exploration. This review paper presents the current scenario of application of MT in the exploration for hydrocarbons and geothermal resources in Asia. While seismics is the most preferred method in oil exploration, it is, however, beset with several limitations in the case of sedimentary targets overlain by basalts or evaporate/carbonate rocks where the high-velocity layers overlying the lower velocity layers pose a problem. In such cases, MT plays an important and, in some cases, a crucial role in mapping these potential reservoirs because of significant resistivity contrast generally observed between the basalts and the underlying sedimentary layers. A few case histories are presented that typically illustrate the role of MT in this context. In the case of geothermal exploration, MT is known to be highly effective in deciphering the target areas because of the conductivity structures arising from the presence and circulation of highly conductive fluids in the geothermal target areas. A few examples of MT studies carried out in some of the potential areas of geothermal significance in the Asian region are also discussed. While it is a relatively favorable situation for application of EM and MT methods in the case of exploration of the high-enthalpy region due to the development of well-defined conceptual models, still the low-enthalpy regions need to be understood well, particularly because of more complex structural patterns and the fluid circulation under relatively low-temperature conditions. Currently, a lot of modeling in both geothermal and hydrocarbon exploration is being done using three-dimensional techniques, and it is the right time to go for integration and three-dimensional joint inversion of the geophysical parameters such as resistivity, velocity, density, from MT, electromagnetics (EM), seismics and gravity.

Complementary Use of Glider Data, Altimetry, and Model for Exploring Mesoscale Eddies in the Tropical Pacific Solomon Sea

NASA Astrophysics Data System (ADS)

Gourdeau, L.; Verron, J.; Chaigneau, A.; Cravatte, S.; Kessler, W.

2017-11-01

Mesoscale activity is an important component of the Solomon Sea circulation that interacts with the energetic low-latitude western boundary currents of the South Tropical Pacific Ocean carrying waters of subtropical origin before joining the equatorial Pacific. Mixing associated with mesoscale activity could explain water mass transformation observed in the Solomon Sea that likely impacts El Niño Southern Oscillation dynamics. This study makes synergetic use of glider data, altimetry, and high-resolution model for exploring mesoscale eddies, especially their vertical structures, and their role on the Solomon Sea circulation. The description of individual eddies observed by altimetry and gliders provides the first elements to characterize the 3-D structure of these tropical eddies, and confirms the usefulness of the model to access a more universal view of such eddies. Mesoscale eddies appear to have a vertical extension limited to the Surface Waters (SW) and the Upper Thermocline Water (UTW), i.e., the first 140-150 m depth. Most of the eddies are nonlinear, meaning that eddies can trap and transport water properties. But they weakly interact with the deep New Guinea Coastal Undercurrent that is a key piece of the equatorial circulation. Anticyclonic eddies are particularly efficient to advect salty and warm SW coming from the intrusion of equatorial Pacific waters at Solomon Strait, and to impact the characteristics of the New Guinea Coastal Current. Cyclonic eddies are particularly efficient to transport South Pacific Tropical Water (SPTW) anomalies from the North Vanuatu Jet and to erode by diapycnal mixing the high SPTW salinity.

Hyperinsulinemia is Associated with Increased Soluble Insulin Receptors Release from Hepatocytes

PubMed Central

Hiriart, Marcia; Sanchez-Soto, Carmen; Diaz-Garcia, Carlos Manlio; Castanares, Diana T.; Avitia, Morena; Velasco, Myrian; Mas-Oliva, Jaime; Macias-Silva, Marina; González-Villalpando, Clicerio; Delgado-Coello, Blanca; Sosa-Garrocho, Marcela; Vidaltamayo, Román; Fuentes-Silva, Deyanira

2014-01-01

It has been generally assumed that insulin circulates freely in blood. However it can also interact with plasma proteins. Insulin receptors are located in the membrane of target cells and consist of an alpha and beta subunits with a tyrosine kinase cytoplasmic domain. The ectodomain, called soluble insulin receptor (SIR) has been found elevated in patients with diabetes mellitus. We explored if insulin binds to SIRs in circulation under physiological conditions and hypothesize that this SIR may be released by hepatocytes in response to high insulin concentrations. The presence of SIR in rat and human plasmas and the culture medium of hepatocytes was explored using Western blot analysis. A purification protocol was performed to isolated SIR using affinity, gel filtration, and ion exchange chromatographies. A modified reverse hemolytic plaque assay was used to measure SIR release from cultured hepatocytes. Incubation with 1 nmol l−1 insulin induces the release of the insulin receptor ectodomains from normal rat hepatocytes. This effect can be partially prevented by blocking protease activity. Furthermore, plasma levels of SIR were higher in a model of metabolic syndrome, where rats are hyperinsulinemic. We also found increased SIR levels in hyperinsulinemic humans. SIR may be an important regulator of the amount of free insulin in circulation. In hyperinsulinemia, the amount of this soluble receptor increases and this could lead to higher amounts of insulin bound to this receptor, rather than free insulin, which is the biologically active form of the hormone. This observation could enlighten the mechanisms of insulin resistance. PMID:24995000

Hyperinsulinemia is Associated with Increased Soluble Insulin Receptors Release from Hepatocytes.

PubMed

Hiriart, Marcia; Sanchez-Soto, Carmen; Diaz-Garcia, Carlos Manlio; Castanares, Diana T; Avitia, Morena; Velasco, Myrian; Mas-Oliva, Jaime; Macias-Silva, Marina; González-Villalpando, Clicerio; Delgado-Coello, Blanca; Sosa-Garrocho, Marcela; Vidaltamayo, Román; Fuentes-Silva, Deyanira

2014-01-01

It has been generally assumed that insulin circulates freely in blood. However it can also interact with plasma proteins. Insulin receptors are located in the membrane of target cells and consist of an alpha and beta subunits with a tyrosine kinase cytoplasmic domain. The ectodomain, called soluble insulin receptor (SIR) has been found elevated in patients with diabetes mellitus. We explored if insulin binds to SIRs in circulation under physiological conditions and hypothesize that this SIR may be released by hepatocytes in response to high insulin concentrations. The presence of SIR in rat and human plasmas and the culture medium of hepatocytes was explored using Western blot analysis. A purification protocol was performed to isolated SIR using affinity, gel filtration, and ion exchange chromatographies. A modified reverse hemolytic plaque assay was used to measure SIR release from cultured hepatocytes. Incubation with 1 nmol l(-1) insulin induces the release of the insulin receptor ectodomains from normal rat hepatocytes. This effect can be partially prevented by blocking protease activity. Furthermore, plasma levels of SIR were higher in a model of metabolic syndrome, where rats are hyperinsulinemic. We also found increased SIR levels in hyperinsulinemic humans. SIR may be an important regulator of the amount of free insulin in circulation. In hyperinsulinemia, the amount of this soluble receptor increases and this could lead to higher amounts of insulin bound to this receptor, rather than free insulin, which is the biologically active form of the hormone. This observation could enlighten the mechanisms of insulin resistance.

Changes of deep Pacific overturning circulation and carbonate chemistry during middle Miocene East Antarctic ice sheet expansion

NASA Astrophysics Data System (ADS)

Ma, Xiaolin; Tian, Jun; Ma, Wentao; Li, Ke; Yu, Jimin

2018-02-01

East Antarctic ice sheet expansion (EAIE) at ∼13.9 Ma in the middle Miocene represents a major climatic event during the long-term Cenozoic cooling, but ocean circulation and carbon cycle changes during this event remain unclear. Here, we present new fish teeth isotope (εNd) and benthic foraminiferal B/Ca records from the South China Sea (SCS), newly integrated meridional Pacific benthic foraminiferal δ18O and δ13C records and simulated results from a biogeochemical box model to explore the responses of deep Pacific Ocean circulation and carbon cycle across EAIE. The εNd and meridional benthic δ13C records reveal a more isolated Pacific Deep Water (PDW) and a sluggish Pacific meridional overturning circulation during the post-EAIE with respect to the pre-EAIE owing to weakened southern-sourced deep water formation. The deep-water [CO23-] and calcium carbonate mass accumulation rate in the SCS display markedly similar increases followed by recoveries to the pre-EAIE level during EAIE, which were probably caused by a shelf-basin shift of CaCO3 deposition and strengthened weathering due to a sea level fall within EAIE. The model results show that the ∼1‰ positive δ13C excursion during EAIE could be attributed to increased weathering of high-δ13C shelf carbonates and a terrestrial carbon reservoir expansion. The drawdown of atmospheric CO2 over the middle Miocene were probably caused by combined effects of increased shelf carbonate weathering, expanded land biosphere carbon storage and a sluggish deep Pacific meridional overturning circulation.

Atmospheric Circulation, Chemistry, and Infrared Spectra of Titan-like Exoplanets around Different Stellar Types

NASA Astrophysics Data System (ADS)

Lora, Juan M.; Kataria, Tiffany; Gao, Peter

2018-01-01

With the discovery of ever smaller and colder exoplanets, terrestrial worlds with hazy atmospheres must be increasingly considered. Our solar system’s Titan is a prototypical hazy planet, whose atmosphere may be representative of a large number of planets in our Galaxy. As a step toward characterizing such worlds, we present simulations of exoplanets that resemble Titan but orbit three different stellar hosts: G, K, and M dwarf stars. We use general circulation and photochemistry models to explore the circulation and chemistry of these Titan-like planets under varying stellar spectra, in all cases assuming a Titan-like insolation. Due to the strong absorption of visible light by atmospheric haze, the redder radiation accompanying later stellar types produces more isothermal stratospheres, stronger meridional temperature gradients at mbar pressures, and deeper and stronger zonal winds. In all cases, the planets’ atmospheres are strongly superrotating, but meridional circulation cells are weaker aloft under redder starlight. The photochemistry of hydrocarbon and nitrile species varies with stellar spectra, with variations in the FUV/NUV flux ratio playing an important role. Our results tentatively suggest that column haze production rates could be similar under all three hosts, implying that planets around many different stars could have similar characteristics to Titan’s atmosphere. Lastly, we present theoretical emission spectra. Overall, our study indicates that, despite important and subtle differences, the circulation and chemistry of Titan-like exoplanets are relatively insensitive to differences in the host star. These findings may be further probed with future space-based facilities, like WFIRST, LUVOIR, HabEx, and OST.

Variability of Changjiang Diluted Water revealed by a 45-year long-term ocean hindcast and Self-Organizing Maps analysis

NASA Astrophysics Data System (ADS)

Zeng, Xiangming; He, Ruoying; Zong, Haibo

2017-08-01

Based on long-term realistic ocean circulation hindcast for in the Bohai, Yellow, and East China Seas, 45 years (1961-2005) of sea surface salinity data were analyzed using Self-Organizing Maps (SOM) to have a better understanding of the Changjiang Diluted Water (CDW) variation. Three spatial patterns were revealed by the SOM: normal, transition, and extension. The normal pattern mainly occurs from December to May while the CDW hugs China's east coast closely and flows southward. The extension pattern is dominant from June to October when the CDW extends northwestward toward Jeju Island in an omega shape. The transition pattern prevails for the rest of the year. Pattern-averaged temperature, circulation, and chlorophyll-a concentration show significant differences. CDW area and its eastern most extension were explored as a function of the Changjiang runoff and regional upwelling index. We found that Changjiang runoff and upwelling index can be reasonable predictors for the overall CDW area, while ambient circulation determines the distribution and structure of the CDW, and thus the CDW eastern most extension.

SARS-CoV related Betacoronavirus and diverse Alphacoronavirus members found in western old-world.

PubMed

Ar Gouilh, Meriadeg; Puechmaille, Sébastien J; Diancourt, Laure; Vandenbogaert, Mathias; Serra-Cobo, Jordi; Lopez Roïg, Marc; Brown, Paul; Moutou, François; Caro, Valérie; Vabret, Astrid; Manuguerra, Jean-Claude

2018-04-01

The emergence of SARS-CoV and MERS-CoV, triggered the discovery of a high diversity of coronaviruses in bats. Studies from Europe have shown that coronaviruses circulate in bats in France but this reflects only a fraction of the whole diversity. In the current study the diversity of coronaviruses circulating in western Europe was extensively explored. Ten alphacoronaviruses in eleven bat species belonging to the Miniopteridae, Vespertilionidae and Rhinolophidae families and, a SARS-CoV-related Betacoronavirus in Rhinolophus ferrumequinum were identified. The diversity and prevalence of bat coronaviruses presently reported from western Europe is much higher than previously described and includes a SARS-CoV sister group. This diversity demonstrates the dynamic evolution and circulation of coronaviruses in this species. That said, the identified coronaviruses were consistently associated with a particular bat species or genus, and these relationships were maintained no matter the geographic location. The observed phylogenetic grouping of coronaviruses from the same species in Europe and Asia, emphasizes the role of host/pathogen coevolution in this group. Copyright © 2018 Elsevier Inc. All rights reserved.

A potential flight evaluation of an upper-surface-blowing/circulation-control-wing concept

NASA Technical Reports Server (NTRS)

Riddle, Dennis W.; Eppel, Joseph C.

1987-01-01

The technology data base for powered lift aircraft design has advanced over the last 15 years. NASA's Quiet Short Haul Research Aircraft (QSRA) has provided a flight verification of upper surface blowing (USB) technology. The A-6 Circulation Control Wing flight demonstration aricraft has provide data for circulation control wing (CCW) technology. Recent small scale wind tunnel model tests and full scale static flow turning test have shown the potential of combining USB with CCW technology. A flight research program is deemed necessary to fully explore the performance and control aspects of CCW jet substitution for the mechanical USB Coanda flap. The required hardware design would also address questions about the development of flight weight ducts and CCW jets and the engine bleed-air capabilities vs requirements. NASA's QSRA would be an optimum flight research vehicle for modification to the USB/CCW configuration. The existing QSRA data base, the design simplicity of the QSRA wing trailing edge controls, availability of engine bleed-air, and the low risk, low cost potential of the suggested program is discussed.

Interactions of Multiple Atmospheric Circulation Drive the Drought in Tarim River Basin.

PubMed

Wu, Yong-Ping; Feng, Guo-Lin; Li, Bai-Lian

2016-05-20

Global warming is likely to cause overall drying of land surfaces and aridity increasing leading to expansion of dry climate zones. There is an increased risk of extremely arid environment and large deserts developed progressively in the central Asia. However, the key factors causing the drying in mid-Asia remain inconclusive. Here, we analyzed the relationship among precipitation, water vapor transportation in Tarim River Basin (TRB) and Multiple Atmospheric Circulation (MAC) to explore the mechanism of MAC driving the drying in TRB, through comparing MAC between abundant and scarce precipitation years. We found that Westerly Circulation (WC) and Asian Summer Monsoon (ASM) are likely to promote the precipitation respectively. Whereas, they not only have their own influence but also restrict each other and facilitate the forming of peculiar water vapor transport channel for TRB, which is probably to restrain the precipitation and its distribution pattern and accelerate the drying in this region. Our results enrich the findings on mechanisms of wet places becoming wetter while dry areas getting drier under the global warming.

Reducing uncertainty in the climatic interpretations of speleothem δ18O

NASA Astrophysics Data System (ADS)

Jex, C. N.; Phipps, S. J.; Baker, A.; Bradley, C.

2013-05-01

We explore two principal areas of uncertainty associated with paleoclimate reconstructions from speleothem δ18O (δ18Ospel): potential non-stationarity in relationships between local climate and larger-scale atmospheric circulation, and routing of water through the karst aquifer. Using a δ18Ospel record from Turkey, the CSIRO Mk3L climate system model and the KarstFOR karst hydrology model, we confirm the stationarity of relationships between cool season precipitation and regional circulation dynamics associated with the North Sea-Caspian pattern since 1 ka. Stalagmite δ18O is predicted for the last 500 years, using precipitation and temperature output from the CSIRO Mk3L model and synthetic δ18O of precipitation as inputs for the KarstFOR model. Interannual variability in the δ18Ospel record is captured by KarstFOR, but we cannot reproduce the isotopically lighter conditions of the sixteenth to seventeenth centuries. We argue that forward models of paleoclimate proxies (such as KarstFOR) embedded within isotope-enabled general circulation models are now required.

Contribution of tropical cyclones to abnormal sea surface temperature warming in the Yellow Sea in December 2004

NASA Astrophysics Data System (ADS)

Kim, Taekyun; Choo, Sung-Ho; Moon, Jae-Hong; Chang, Pil-Hun

2017-12-01

Unusual sea surface temperature (SST) warming occurred over the Yellow Sea (YS) in December 2004. To identify the causes of the abnormal SST warming, we conducted an analysis on atmospheric circulation anomalies induced by tropical cyclones (TCs) and their impacts on upper ocean characteristics using multiple datasets. With the analysis of various datasets, we explored a new aspect of the relationship between TC activity and SST. The results show that there is a significant link between TC activity over the Northwest Pacific (NWP) and SST in the YS. The integrated effect of consecutive TCs activity induces a large-scale atmospheric cyclonic circulation anomaly over the NWP and consequently anomalous easterly winds over the YS and East China Sea. The mechanism of the unusually warm SST in the YS can be explained by considering TCs acting as an important source of Ekman heat transport that results in substantial intrusion of relatively warm surface water into the YS interior. Furthermore, TC-related circulation anomalies contribute to the retention of the resulting warm SST anomalies in the entire YS.

Interactions of Multiple Atmospheric Circulation Drive the Drought in Tarim River Basin

NASA Astrophysics Data System (ADS)

Wu, Yong-Ping; Feng, Guo-Lin; Li, Bai-Lian

2016-05-01

Global warming is likely to cause overall drying of land surfaces and aridity increasing leading to expansion of dry climate zones. There is an increased risk of extremely arid environment and large deserts developed progressively in the central Asia. However, the key factors causing the drying in mid-Asia remain inconclusive. Here, we analyzed the relationship among precipitation, water vapor transportation in Tarim River Basin (TRB) and Multiple Atmospheric Circulation (MAC) to explore the mechanism of MAC driving the drying in TRB, through comparing MAC between abundant and scarce precipitation years. We found that Westerly Circulation (WC) and Asian Summer Monsoon (ASM) are likely to promote the precipitation respectively. Whereas, they not only have their own influence but also restrict each other and facilitate the forming of peculiar water vapor transport channel for TRB, which is probably to restrain the precipitation and its distribution pattern and accelerate the drying in this region. Our results enrich the findings on mechanisms of wet places becoming wetter while dry areas getting drier under the global warming.

Prediction of circulation control performance characteristics for Super STOL and STOL applications

NASA Astrophysics Data System (ADS)

Naqvi, Messam Abbas

The rapid air travel growth during the last three decades, has resulted in runway congestion at major airports. The current airports infrastructure will not be able to support the rapid growth trends expected in the next decade. Changes or upgrades in infrastructure alone would not be able to satisfy the growth requirements, and new airplane concepts such as the NASA proposed Super Short Takeoff and Landing and Extremely Short Takeoff & Landing (ESTOL) are being vigorously pursued. Aircraft noise pollution during Takeoff & Landing is another serious concern and efforts are aimed to reduce the airframe noise produced by Conventional High Lift Devices during Takeoff & Landing. Circulation control technology has the prospect of being a good alternative to resolve both the aforesaid issues. Circulation control airfoils are not only capable of producing very high values of lift (Cl values in excess of 8.0) at zero degree angle of attack, but also eliminate the noise generated by the conventional high lift devices and their associated weight penalty as well as their complex operation and storage. This will ensure not only satisfying the small takeoff and landing distances, but minimal acoustic signature in accordance with FAA requirements. The Circulation Control relies on the tendency of an emanating wall jet to independently control the circulation and lift on an airfoil. Unlike, conventional airfoil where rear stagnation point is located at the sharp trailing edge, circulation control airfoils possess a round trailing edge, therefore the rear stagnation point is free to move. The location of rear stagnation point is controlled by the blown jet momentum. This provides a secondary control in the form of jet momentum with which the lift generated can be controlled rather the only available control of incidence (angle of attack) in case of conventional airfoils. The use of Circulation control despite its promising potential has been limited only to research applications due to the lack of a simple prediction capability. This research effort was focused on the creation of a rapid prediction capability of Circulation Control Aerodynamic Characteristics which could help designers with rapid performance estimates for design space exploration. A morphological matrix was created with the available set of options which could be chosen to create this prediction capability starting with purely analytical physics based modeling to high fidelity CFD codes. Based on the available constraints, and desired accuracy meta-models have been created around the two dimensional circulation control performance results computed using Navier Stokes Equations (Computational Fluid Dynamics). DSS2, a two dimensional RANS code written by Professor Lakshmi Sankar was utilized for circulation control airfoil characteristics. The CFD code was first applied to the NCCR 1510-7607N airfoil to validate the model with available experimental results. It was then applied to compute the results of a fractional factorial design of experiments array. Metamodels were formulated using the neural networks to the results obtained from the Design of Experiments. Additional validation runs were performed to validate the model predictions. Metamodels are not only capable of rapid performance prediction, but also help generate the relation trends of response matrices with control variables and capture the complex interactions between control variables. Quantitative as well as qualitative assessments of results were performed by computation of aerodynamic forces & moments and flow field visualizations. Wing characteristics in three dimensions were obtained by integration over the whole wing using Prandtl's Wing Theory. The baseline Super STOL configuration [3] was then analyzed with the application of circulation control technology. The desired values of lift and drag to achieve the target values of Takeoff & Landing performance were compared with the optimal configurations obtained by the model. The same optimal configurations were then subjected to Super STOL cruise conditions to perform a trade off analysis between Takeoff and Cruise Performance. Supercritical airfoils modified for circulation control were also thoroughly analyzed for Takeoff and Cruise performance and may constitute a viable option for Super STOL & STOL Designs. The prediction capability produced by this research effort can be integrated with the current conceptual aircraft modeling & simulation framework. The prediction tool is applicable within the selected ranges of each variable, but methodology and formulation scheme adopted can be applied to any other design space exploration.

Observing the polar oceans with spaceborne radar

NASA Technical Reports Server (NTRS)

Rothrock, Drew

1986-01-01

The application of spaceborne imaging radar data to polar oceanography and sea ice is explored. Several problems come to mind which are presently ripe with ideas and models, but are in need of new data, SAR data, for any progress to be made. These are the study of the ice mass balance, the ice momentum balance, and the circulation of the Arctic Ocean. These problems are described along with the data which is applicable to them and can be extracted from SAR imagery. Some uses are discussed of these data to explore mesoscale processes which affect the oceans and ice cover.

Surgeon and Safari: producing valuable bodies in Johannesburg.

PubMed

Mazzaschi, Andrew

2011-01-01

This essay explores how concepts of value and cheapness circulate around the bodies of clients of the Johannesburg-based cosmetic surgery tourism company Surgeon and Safari. I show how the production of a luxurious experience and the mitigation of risk take place within a transnational network enabled by the presence of medical tourism in multiple locales. By placing Surgeon and Safari's activities within the context of the neoliberalization of health care in South Africa, I explore how the division between private versus public health spaces functions as both a technique of valuing clients' bodies and as a process of racialization.

Space Geodesy: The Cross-Disciplinary Earth science (Vening Meinesz Medal Lecture)

NASA Astrophysics Data System (ADS)

Shum, C. K.

2012-04-01

Geodesy during the onset of the 21st Century is evolving into a transformative cross-disciplinary Earth science field. The pioneers before or after the discipline Geodesy was defined include Galileo, Descartes, Kepler, Newton, Euler, Bernoulli, Kant, Laplace, Airy, Kelvin, Jeffreys, Chandler, Meinesz, Kaula, and others. The complicated dynamic processes of the Earth system manifested by interactions between the solid Earth and its fluid layers, including ocean, atmosphere, cryosphere and hydrosphere, and their feedbacks are linked with scientific problems such as global sea-level rise resulting from natural and anthropogenic climate change. Advances in the precision and stability of geodetic and fundamental instrumentations, including clocks, satellite or quasar tracking sensors, altimetry and lidars, synthetic aperture radar interferometry (InSAR), InSAR altimetry, gravimetry and gradiometry, have enabled accentuate and transformative progress in cross-disciplinary Earth sciences. In particular, advances in the measurement of the gravity with modern free-fall methods have reached accuracies of 10-9 g (~1 μGal or 10 nm/s2) or better, allowing accurate measurements of height changes at ~3 mm relative to the Earth's center of mass, and mass transports within the Earth interior or its geophysical fluids, enabling global quantifications of climate-change signals. These contemporary space geodetic and in situ sensors include, but not limited to, satellite radar and laser altimetry/lidars, GNSS/SLR/VLBI/DORIS, InSAR, spaceborne gravimetry from GRACE (Gravity Recovery And Climate Experiment twin-satellite mission) and gradiometry from GOCE (Global Ocean Circulation Experiment), tide gauges, and hydrographic data (XBT/MBT/Argo). The 2007 Intergovernmental Panel for Climate Change (IPCC) study, the Fourth Assessment Report (AR4), substantially narrowed the discrepancy between observation and the known geophysical causes of sea-level rise, but significant uncertainties remain, notably in the discrepancies of contributions from the ice-reservoirs (ice-sheet and mountain glaciers/ice caps) and our knowledge in the solid Earth glacial isostatic adjustment (GIA), to the present-day and 20th Century global sea-level rise. Here we report our use of contemporary space geodetic observations and novel methodologies to address a few of the open Earth science questions, including the potential quantifications of the major geophysical contributions to or causing present-day global sea-level rise, and the subsequent narrowing of the current sea-level budget discrepancy.

Enhancing Therapeutic Cellular Prostate Cancer Vaccines

DTIC Science & Technology

2012-06-01

oxygen -mediated mobilization of mesenchymal stem cell and progenitors (MSCs)”, Division of Preventive, Occupational, And Aerospace Medicine...postdoctoral fellow Completed: Tittle: Hyperbaric oxygen as mobilizer of stem cells and progenitors in senescent mice (Stanimir Vuk-Pavlovic, P.I.). Co... stem and progenitor cells (HSPCs) and mesenchymal stromal cells (MSCs) from bone marrow into circulation of old mice were explored. Specific Aims:

Einstein's Tea Leaves and Pressure Systems in the Atmosphere

ERIC Educational Resources Information Center

Tandon, Amit; Marshall, John

2010-01-01

Tea leaves gather in the center of the cup when the tea is stirred. In 1926 Einstein explained the phenomenon in terms of a secondary, rim-to-center circulation caused by the fluid rubbing against the bottom of the cup. This explanation can be connected to air movement in atmospheric pressure systems to explore, for example, why low-pressure…

Exploring the Role of Digital Data in Contemporary Schools and Schooling--"200,000 Lines in an Excel Spreadsheet"

ERIC Educational Resources Information Center

Selwyn, Neil; Henderson, Michael; Chao, Shu-Hua

2015-01-01

The generation, processing and circulation of data in digital form is now an integral aspect of contemporary schooling. Based upon empirical study of two secondary school settings in Australia, this paper considers the different forms of digitally-based "data work" engaged in by school leaders, managers, administrators and teachers. In…

Violence against Brazilian Women in Public and Mediatic Spheres

ERIC Educational Resources Information Center

Souza-Leal, Bruno; de-Carvalho, Carlos-Alberto; Antunes, Elton

2018-01-01

This paper explores the capacity of the media to incorporate controversies in circulation in the public sphere. For that, it is based on the analysis of a set of 607 news stories about violence against women in context of gender relations and proximity, collected in nine Brazilian media during the years of 2013 and 2014. Recognized as one of the…

Internal structure of mushroom-shaped salt diapirs

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1989-01-01

This book focuses on the dynamics and kinematics of salt diapirs with crestal bulbs shaped like a mushroom, one of the most complex types of diapirs, as interpreted by experimental modeling and from naturally occurring examples. Direct, practical applications of this research include use in the evaluation of salt domes as repositories for radioactive waste, in the exploration and production of salt, potash, and sulfur, and in the search for subtle hydrocarbon traps. The authors conducted 8 centrifuge experiments, which produced more than 100 model diapirs. These experiments were dynamically scaled to U.S. Gulf Coast salt domes, but the qualitativemore » results are also relevant to salt diapirs in other provinces and to granitoid diapirs penetrating metamorphic crust. The centrifuged domes grew under overburdens of constant thickness or under aggrading and prograding overburdens, a new experimental approach. Results indicate that external mushroom structure results from toroidal circulation of buoyant source and immediate cover having similar effective viscosities, whereas internal structure is produced by toroidal circulation confined within the diapir. The internal diapir structure elucidates the mechanics of emplacement and indicates whether an external mushroom shape can be expected and sought by further exploration.« less

Psoriasis: in between the skin and the fat.

PubMed

Ståhle, Mona

2015-03-01

Substantial epidemiological evidence indicates that psoriasis associates with a predisposition to develop metabolic dysregulation leading to obesity and insulin resistance. However, the nature of this association and the potential underlying mechanisms remain unclear. In a recent report, Gerdes et al. explored the hypothesis that wingless-type MMTV integration site, Wnt5a, which has been linked to aberrant fat cell metabolism, may be driving this process. In this study, the authors compare circulating serum levels of Wnt5a in individuals with psoriasis and compare with healthy controls matched for age, gender and BMI. The bottom-line results show higher levels of Wnt5a in psoriasis patients irrespective of BMI compared to the matched non-psoriatic controls, indicating that psoriasis per se may result in increased secretion of Wnt5a into the circulation. In addition, there was a significant difference among patients with higher levels of Wnt5a in the obese psoriasis population. The study, even though being purely descriptive, may serve to inspire a more mechanistic approach exploring not only Wnt5a, but other inflammatory pathways in between the skin and the fat. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Approximate Stokes Drift Profiles and their use in Ocean Modelling

NASA Astrophysics Data System (ADS)

Breivik, Oyvind; Bidlot, Jea-Raymond; Janssen, Peter A. E. M.; Mogensen, Kristian

2016-04-01

Deep-water approximations to the Stokes drift velocity profile are explored as alternatives to the monochromatic profile. The alternative profiles investigated rely on the same two quantities required for the monochromatic profile, viz the Stokes transport and the surface Stokes drift velocity. Comparisons against parametric spectra and profiles under wave spectra from the ERA-Interim reanalysis and buoy observations reveal much better agreement than the monochromatic profile even for complex sea states. That the profiles give a closer match and a more correct shear has implications for ocean circulation models since the Coriolis-Stokes force depends on the magnitude and direction of the Stokes drift profile and Langmuir turbulence parameterizations depend sensitively on the shear of the profile. Of the two Stokes drift profiles explored here, the profile based on the Phillips spectrum is by far the best. In particular, the shear near the surface is almost identical to that influenced by the f-5 tail of spectral wave models. The NEMO general circulation ocean model was recently extended to incorporate the Stokes-Coriolis force along with two other wave-related effects. The ECWMF coupled atmosphere-wave-ocean ensemble forecast system now includes these wave effects in the ocean model component (NEMO).

Leukocyte- and endothelial-derived microparticles: a circulating source for fibrinolysis

PubMed Central

Lacroix, Romaric; Plawinski, Laurent; Robert, Stéphane; Doeuvre, Loïc; Sabatier, Florence; Martinez de Lizarrondo, Sara; Mezzapesa, Anna; Anfosso, Francine; Leroyer, Aurelie S.; Poullin, Pascale; Jourde, Noémie; Njock, Makon-Sébastien; Boulanger, Chantal M.; Anglés-Cano, Eduardo; Dignat-George, Françoise

2012-01-01

Background We recently assigned a new fibrinolytic function to cell-derived microparticles in vitro. In this study we explored the relevance of this novel property of microparticles to the in vivo situation. Design and Methods Circulating microparticles were isolated from the plasma of patients with thrombotic thrombocytopenic purpura or cardiovascular disease and from healthy subjects. Microparticles were also obtained from purified human blood cell subpopulations. The plasminogen activators on microparticles were identified by flow cytometry and enzyme-linked immunosorbent assays; their capacity to generate plasmin was quantified with a chromogenic assay and their fibrinolytic activity was determined by zymography. Results Circulating microparticles isolated from patients generate a range of plasmin activity at their surface. This property was related to a variable content of urokinase-type plasminogen activator and/or tissue plasminogen activator. Using distinct microparticle subpopulations, we demonstrated that plasmin is generated on endothelial and leukocyte microparticles, but not on microparticles of platelet or erythrocyte origin. Leukocyte-derived microparticles bear urokinase-type plasminogen activator and its receptor whereas endothelial microparticles carry tissue plasminogen activator and tissue plasminogen activator/inhibitor complexes. Conclusions Endothelial and leukocyte microparticles, bearing respectively tissue plasminogen activator or urokinase-type plasminogen activator, support a part of the fibrinolytic activity in the circulation which is modulated in pathological settings. Awareness of this blood-borne fibrinolytic activity conveyed by microparticles provides a more comprehensive view of the role of microparticles in the hemostatic equilibrium. PMID:22733025

Exploring the sensitivity of global ocean circulation to future ice loss from Antarctica

DOE Office of Scientific and Technical Information (OSTI.GOV)

Condron, Alan

The sensitivity of the global ocean circulation and climate to large increases in iceberg calving and meltwater discharges from the Antarctic Ice Sheet (AIS) are rarely studied and poorly understood. The requirement to investigate this topic is heightened by growing evidence that the West Antarctic Ice Sheet (WAIS) is vulnerable to rapid retreat and collapse on multidecadal-to-centennial timescales. Observations collected over the last 30 years indicate that the WAIS is now losing mass at an accelerated and that a collapse may have already begun in the Amundsen Sea sector. In addition, some recent future model simulations of the AIS showmore » the potential for rapid ice sheet retreat in the next 50 – 300 years. Such a collapse would be associated with the discharge of enormous volumes of ice and meltwater to the Southern Ocean. This project funds PI Condron to begin assessing the sensitivity of the global ocean circulation to projected increases in meltwater discharge and iceberg calving from the AIS for the next 50 – 100 years. A series of climate model simulations will determine changes in ocean circulation and temperature at the ice sheet grounding line, the role of mesoscale ocean eddies in mixing and transporting freshwater away from the continent to deep water formation regions, and the likely impact on the northward transport of heat to Europe and North America.« less

Self-renewal and circulating capacities of metastatic hepatocarcinoma cells required for collaboration between TM4SF5 and CD44

PubMed Central

Lee, Doohyung; Lee, Jung Weon

2015-01-01

Tumor metastasis involves circulating and tumor-initiating capacities of metastatic cancer cells. Hepatic TM4SF5 promotes EMT for malignant growth and migration. Hepatocellular carcinoma (HCC) biomarkers remain unexplored for metastatic potential throughout metastasis. Here, novel TM4SF5/CD44 interaction-mediated self-renewal and circulating tumor cell (CTC) capacities were mechanistically explored. TM4SF5-dependent sphere growth was correlated with CD133+, CD24-, ALDH activity, and a physical association between CD44 and TM4SF5. The TM4SF5/CD44 interaction activated c-Src/STAT3/ Twist1/ B mi1 signaling for spheroid formation, while disturbing the interaction, expression, or activity of any component in this signaling pathway inhibited spheroid formation. In serial xenografts of less than 5,000 cells/injection, TM4SF5-positive tumors exhibited locally-increased CD44 expression, suggesting tumor cell differentiation. TM4SF5-positive cells were identified circulating in blood 4 to 6 weeks after orthotopic liver-injection. Anti-TM4SF reagents blocked their metastasis to distal intestinal organs. Altogether, our results provide evidence that TM4SF5 promotes self-renewal and CTC properties supported by CD133+/TM4SF5+/CD44+(TM4SF5-bound)/ALDH+/ CD24- markers during HCC metastasis. [BMB Reports 2015; 48(3): 127-128] PMID:25772760

Circulating Cell Free Tumor DNA Detection as a Routine Tool for Lung Cancer Patient Management

PubMed Central

Vendrell, Julie A.; Mau-Them, Frédéric Tran; Béganton, Benoît; Godreuil, Sylvain; Coopman, Peter; Solassol, Jérôme

2017-01-01

Circulating tumoral DNA (ctDNA), commonly named “liquid biopsy”, has emerged as a new promising noninvasive tool to detect biomarker in several cancers including lung cancer. Applications involving molecular analysis of ctDNA in lung cancer have increased and encompass diagnosis, response to treatment, acquired resistance and prognosis prediction, while bypassing the problem of tumor heterogeneity. ctDNA may then help perform dynamic genetic surveillance in the era of precision medicine through indirect tumoral genomic information determination. The aims of this review were to examine the recent technical developments that allowed the detection of genetic alterations of ctDNA in lung cancer. Furthermore, we explored clinical applications in patients with lung cancer including treatment efficiency monitoring, acquired therapy resistance mechanisms and prognosis value. PMID:28146051

[Tissue oxygen saturation in the critically ill patient].

PubMed

Gruartmoner, G; Mesquida, J; Baigorri, F

2014-05-01

Hemodynamic resuscitation seeks to correct global macrocirculatory parameters of pressure and flow. However, current evidence has shown that despite the normalization of these global parameters, microcirculatory and regional perfusion alterations can persist, and these alterations have been independently associated with a poorer patient prognosis. This in turn has lead to growing interest in new technologies for exploring regional circulation and microcirculation. Near infra-red spectroscopy allows us to monitor tissue oxygen saturation, and has been proposed as a noninvasive, continuous and easy-to-obtain measure of regional circulation. The present review aims to summarize the existing evidence on near infra-red spectroscopy and its potential clinical role in the resuscitation of critically ill patients in shock. Copyright © 2013 Elsevier España, S.L. and SEMICYUC. All rights reserved.

Climate Dynamics and Hysteresis at Low and High Obliquity

NASA Astrophysics Data System (ADS)

Colose, C.; Del Genio, A. D.; Way, M.

2017-12-01

We explore the large-scale climate dynamics at low and high obliquity for an Earth-like planet using the ROCKE-3D (Resolving Orbital and Climate Keys of Earth and Extraterrestrial Environments with Dynamics) 3-D General Circulation model being developed at NASA GISS as part of the Nexus for Exoplanet System Science (NExSS) initiative. We highlight the role of ocean heat storage and transport in determining the seasonal cycle at high obliquity, and describe the large-scale circulation and resulting regional climate patterns using both aquaplanet and Earth topographical boundary conditions. Finally, we contrast the hysteresis structure to varying CO2 concentration for a low and high obliquity planet near the outer edge of the habitable zone. We discuss the prospects for habitability for a high obliquity planet susceptible to global glaciation.

Investigation of Electrostatic Accelerometer in HUST for Space Science Missions

NASA Astrophysics Data System (ADS)

Bai, Yanzheng; Hu, Ming; Li, Gui; Liu, Li; Qu, Shaobo; Wu, Shuchao; Zhou, Zebing

2014-05-01

High-precision electrostatic accelerometers are significant payload in CHAMP, GRACE and GOCE gravity missions to measure the non-gravitational forces. In our group, space electrostatic accelerometer and inertial sensor based on the capacitive sensors and electrostatic control technique has been investigated for space science research in China such as testing of equivalence principle (TEPO), searching non-Newtonian force in micrometer range, satellite Earth's field recovery and so on. In our group, a capacitive position sensor with a resolution of 10-7pF/Hz1/2 and the μV/Hz1/2 level electrostatic actuator are developed. The fiber torsion pendulum facility is adopt to measure the parameters of the electrostatic controlled inertial sensor such as the resolution, and the electrostatic stiffness, the cross couple between different DOFs. Meanwhile, high voltage suspension and free fall methods are applied to verify the function of electrostatic accelerometer. Last, the engineering model of electrostatic accelerometer has been developed and tested successfully in space and preliminary results are present.

Hierarchical matrices implemented into the boundary integral approaches for gravity field modelling

NASA Astrophysics Data System (ADS)

Čunderlík, Róbert; Vipiana, Francesca

2017-04-01

Boundary integral approaches applied for gravity field modelling have been recently developed to solve the geodetic boundary value problems numerically, or to process satellite observations, e.g. from the GOCE satellite mission. In order to obtain numerical solutions of "cm-level" accuracy, such approaches require very refined level of the disretization or resolution. This leads to enormous memory requirements that need to be reduced. An implementation of the Hierarchical Matrices (H-matrices) can significantly reduce a numerical complexity of these approaches. A main idea of the H-matrices is based on an approximation of the entire system matrix that is split into a family of submatrices. Large submatrices are stored in factorized representation, while small submatrices are stored in standard representation. This allows reducing memory requirements significantly while improving the efficiency. The poster presents our preliminary results of implementations of the H-matrices into the existing boundary integral approaches based on the boundary element method or the method of fundamental solution.

[Effect of Alloxan-induced diabetes mellitus on the functions of bone marrow-derived and circulating endothelial progenitor cells].

PubMed

Tan, Q; Li, G P; Wang, Q S; Zheng, C H; Zhang, S Y

2017-07-25

Objective: To explore whether diabetes mellitus (DM) impairs functions of bone marrow-derived endothelial progenitor cells (BM-EPC) and circulating EPC. Methods: Diabetic model of rabbit was induced by Alloxan injection and the rabbits were then randomly divided into three groups: BM-EPC group, circulating EPC group, and DM group, with six rabbits in each group. Another 6 normal rabbits were enrolled as normal control group as well. 8 weeks later, BM-EPC and circulating EPC from diabetic and healthy rabbits were isolated and cultured. Colony number, proliferation, adhesion and tube formation function were detected. Exogenous diabetic BM-EPC and circulating EPC were analyzed for therapeutic efficacy in acute ischemia model of diabetic rabbits. Left ventricular (LV) function was assessed using Echocardiography. Capillary density and fibrosis area were evaluated by confocal laser scanning microscope (CLSM) and Masson-trichrome staining. The mRNA expression of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) was analyzed using real-time quantitive PCR. Results: Colony number, proliferation, adhesion and tube formation function of diabetic circulating EPC were significantly reduced compared with healthy rabbits. DM impaired tube-forming ability of BM-EPC, but did not influence colony number, proliferation and adhesion function. Compared with circulating EPC and control group, BM-EPC group had fewer fibrosis area (6.98%±0.94% vs 13.03%±2.97% and 15.84%±4.74%, both P =0.001), higher capillary density [(792±87) vs (528±71) and (372±77) vessels/mm(2,) both P <0.001], higher mRNA expression of VEGF (6.25±2.33 vs 2.19±1.01 and 1.55±0.52, both P <0.001) and bFGF (6.38±2.65 vs 1.24±0.76 and 1.18±0.82, both P <0.001), higher left ventricular ejection fraction (LVEF) (61%±4% vs 47%±5% and 50%±10%, both P <0.05). Conclusions: DM not only impaired functions of circulating EPC, but also influenced tube formation function of BM-EPC. Auto transplantation of BM-EPC may rescue the ischemic myocardium by neovascularization and paracrine effect in diabetic rabbits.

Planetary circulations in the presence of transient and self-induced heating

NASA Technical Reports Server (NTRS)

Salby, Murry L.; Garcia, Rolando R.

1993-01-01

The research program focuses on large-scale circulations and their interaction with the global convective pattern. An 11-year record of global cloud imagery and contemporaneous fields of motion and temperature have been used to investigate organized convection and coherent variability of the tropical circulation operating on intraseasonal time scales. This study provides a detailed portrait of tropical variability associated with the so-called Madden-Julian Oscillation (MJO). It reveals the nature, geographical distribution, and seasonality of discrete convective signal, which is a measure of feedback between the circulation and the convective pattern. That discrete spectral behavior has been evaluated in light of natural variability of the ITCZ associated with climatological convection. A composite signature of the MJO, based on cross-covariance statistics of cloud cover, motion, and temperature, has been constructed to characterize the lifecycle of the disturbance in terms of these properties. The composite behavior has also been used to investigate the influence the MJO exerts on the zonal-mean circulation and the involvement of the MJO in transfers of momentum between the atmosphere and the solid Earth. The aforementioned observational studies have led to the production of two animations. One reveals the convective signal in band-pass filtered OLR and compares it to climatological convection. The other is a 3-dimensional visualization of the composite lifecycle of the MJO. With a clear picture of the MJO in hand, feedback between the circulation and the convective pattern can be diagnosed meaningfully in numerical simulations. This process is being explored in calculations with the linearized primitive equations on the sphere in the presence of realistic stability and shear. The numerical framework represents climatological convection as a space-time stochastic process and wave-induced convection in terms of the vertically-integrated moisture flux convergence. In these calculations, frictional convergence near the equator emerges as a key to feedback between the circulation and the convective pattern. At low latitudes, nearly geostrophic balance in the boundary layer gives way to frictional balance. This shifts the wave-induced convection into phase with the temperature anomaly and allows the attending heating to feed back positively onto the circulation. The calculations successfully reproduce the salient features of the MJO. They are being used to understand the growth and decay phases of the composite lifecycle and the conditions that favor amplification of the MJO.

Exploring Western and Eastern Pacific contributions to the 21st century Walker circulation intensification and teleconnected precipitation declines (Invited)

NASA Astrophysics Data System (ADS)

Funk, C. C.; Hoerling, M. P.; Hoell, A.; Verdin, J. P.; Robertson, F. R.; Alured, D.; Liebmann, B.

2013-12-01

As the earth's population, industry, and agricultural systems continue to expand and increase demand for limited hydrologic resources, developing better tools for monitoring, analyzing and perhaps even predicting decadal variations in precipitation will enable the climate community to better inform important policy and management decisions. To this end, in support of the development and humanitarian relief efforts of the US Agency for International Development, USGS, NOAA, UC Santa Barbara, and NASA scientists have been exploring global precipitation trends using observations and new ensembles of atmospheric general circulation model (AGCM) simulations from the ECHAM5, GFSv2, CAM4 and GMAO models. This talk summarizes this work, and discusses how combined analyses of AGCM simulations and observations might lead to credible decadal projections, for some regions and seasons, based on the strength of the Indo-Pacific warming signal. Focusing on the late boreal spring, a critical period for food insecure Africa, we begin by linearly decomposing 1900-2012 sea surface temperatures (SST) into components loading strongly in the Indo-Western Pacific and Eastern Pacific. Eastern Pacific (EP) SST variations are based on regressions with three time series: the first and second principal components of equatorial Pacific SST and the Pacific Decadal Oscillation. These influences are removed from Indo-Pacific SSTs, and the Indo-Western Pacific (IWP) SST variations are defined by the 1st principal component of the residuals, which we refer to as the Indo-West Pacific Warming Signal (IWPWS). The pattern of IWPWS SST changes resembles recent assessments of centennial warming, and identifies rapid warming in the equatorial western Pacific and north and south Pacific convergence zones. The circulation impacts of IWP and EP SST forcing are explored in two ways. First, assuming linear SST forcing relationships, IWP and EP decompositions of ECHAM5, GFS, CAM4 and GMAO AGCM simulations are presented. These results suggest that a substantial component of the recent Walker circulation intensification has been related to the IWPWS. The IWPWS warming extends from just north of Papua New Guinea to just west of Hawaii, and appears associated with SLP, wind and rainfall responses consistent with enhanced Indo-Pacific convection. These decomposition results are compared with a set of numerical simulation experiments based on the ECHAM5 and GFS models forced with characteristic IWP and EP SST for 1983-1996 and 1999-2012. The talk concludes with a tentative discussion of the decadal predictability associated with the IWPWS. Using both observed and model-simulated precipitation, we briefly explore potential IWPWS drought teleconnection regions in the Americas, Asia, Middle East, and Eastern Africa. Figure 1. Western Pacific and Eastern Pacific SST changes between 1999-2012 and 1983-1996. Figure 2. Western Pacific and Eastern Pacific GPCP precipitation changes between 1999-2012 and 1983-1996.

An event-based approach to understanding decadal fluctuations in the Atlantic meridional overturning circulation

NASA Astrophysics Data System (ADS)

Allison, Lesley; Hawkins, Ed; Woollings, Tim

2015-01-01

Many previous studies have shown that unforced climate model simulations exhibit decadal-scale fluctuations in the Atlantic meridional overturning circulation (AMOC), and that this variability can have impacts on surface climate fields. However, the robustness of these surface fingerprints across different models is less clear. Furthermore, with the potential for coupled feedbacks that may amplify or damp the response, it is not known whether the associated climate signals are linearly related to the strength of the AMOC changes, or if the fluctuation events exhibit nonlinear behaviour with respect to their strength or polarity. To explore these questions, we introduce an objective and flexible method for identifying the largest natural AMOC fluctuation events in multicentennial/multimillennial simulations of a variety of coupled climate models. The characteristics of the events are explored, including their magnitude, meridional coherence and spatial structure, as well as links with ocean heat transport and the horizontal circulation. The surface fingerprints in ocean temperature and salinity are examined, and compared with the results of linear regression analysis. It is found that the regressions generally provide a good indication of the surface changes associated with the largest AMOC events. However, there are some exceptions, including a nonlinear change in the atmospheric pressure signal, particularly at high latitudes, in HadCM3. Some asymmetries are also found between the changes associated with positive and negative AMOC events in the same model. Composite analysis suggests that there are signals that are robust across the largest AMOC events in each model, which provides reassurance that the surface changes associated with one particular event will be similar to those expected from regression analysis. However, large differences are found between the AMOC fingerprints in different models, which may hinder the prediction and attribution of such events in reality.

Contribution of the exploration of deep crystalline fractured reservoir of Soultz to the knowledge of enhanced geothermal systems (EGS)

NASA Astrophysics Data System (ADS)

Genter, Albert; Evans, Keith; Cuenot, Nicolas; Fritsch, Daniel; Sanjuan, Bernard

2010-07-01

Over the past 20 years, the Soultz experimental geothermal site in Alsace, France, has been explored in detail by the drilling of five boreholes, three of which extend to 5 km depth. Data on geology, fluid geochemistry, temperature, microseismicity, hydraulics and geomechanics have been collected and interpreted by the various teams from the participating European countries and their international collaborators. Two reservoirs have been developed within granite at depths of 3.5 and 5 km. The reservoir at 3.5 km was formed from two wells, 450 m apart, both of which were subjected to hydraulic stimulation injections. The system was circulated continuously for 4 months at 25 kg/s in 1997 using a downhole pump, and yielded results that were extremely encouraging. The impedance reduced to 0.1 MPa/l/s, the first time this long-standing target had been attained. Construction of a deeper system began shortly afterwards with the drilling of 3 deviated wells to 5 km true vertical depth, where the temperature was 200 °C. The wells were drilled in a line, 600 m apart at reservoir depth, and all were hydraulically stimulated and subjected to acidization injections. The 3-well system was circulated under buoyancy drive for 5 months in 2005 with injection in the central well, GPK-3, and production from the two outer wells, GPK-2 and GPK-4. This showed good linkage between one doublet pair, but not the other. Further acidization operations on the low-productivity well led to its productivity increasing to almost the same level as the other wells. Construction of a power plant at the site was completed in 2008 and a trial circulation with a production pump in one well and the other shut-in was conducted with power production. Downhole pumps are now installed in both production wells in preparation for long-term circulation of the system. In this article we present an overview of the principal accomplishments at Soultz over the past two decades, and highlight the main results, issues identified, and lessons learnt.

Keyhole Approach Combined With External Ventricular Drainage for Ruptured, Poor-Grade, Anterior Circulation Cerebral Aneurysms

PubMed Central

Zheng, Shu-Fa; Yao, Pei-Sen; Yu, Liang-Hong; Kang, De-Zhi

2015-01-01

Abstract Poor-grade ruptured anterior circulation cerebral aneurysms are frequently associated with severe vasospasm and high morbidity rates despite recent remarkable advances in endovascular coiling. Here, we explored the feasibility of keyhole approach combined with external ventricular drainage for ruptured, poor-grade, anterior circulation cerebral aneurysms. We retrospectively assessed the records of 103 patients with ruptured, Hunt and Hess grade IV or V, anterior circulation cerebral aneurysms. The patients were divided into 2 groups (conservative group and surgical group). In surgical group, patients were divided into 2 subgroups according to surgical time (within 24 hours and at 24–48 hours). Clinical outcome was assessed at the 6-month follow-up and categorized according to modified Rankin Scale (mRS) score. Twenty percent of patients (9/44) in conservative group obtained good outcome, while 54% (32/54) in surgical group (P < 0.05). Mortality was 73% in conservative group and 40% in surgical group, respectively. In surgical group, age, Hunt and Hess grade (IV or V), and timing of intervention (<24 hours or later) influenced the clinical outcome of the patients (P < 0.05), while sex, Fisher grade, hydrocephalus, the location of aneurysms, and cerebral vasospasm (CVS) not (P > 0.05). Furthermore, 65% of patients (22/34) operated within 24 hours after onset of hemorrhage had a good outcome compared with 20% of patients (5/25) operated at 24 to 48 hours in surgical group (P < 0.05). The results indicate that keyhole approach combined with external ventricular drainage is a safe and reliable treatment for ruptured, poor-grade, anterior circulation cerebral aneurysms in early stage, which will reduce mortality. PMID:26705215

Assessment of Radiation Risk by Circulating microRNAs

NASA Astrophysics Data System (ADS)

Wang, Jufang

2016-07-01

Highly energized particles delivered by galactic cosmic rays as well as solar particle events are one of the most severe detrimental factors to the health of crews during long-term space missions. Researches related to the assessment of radiation risk have been carried out with ground-based accelerator facilities all around the world. Circulating microRNAs (miRNAs) in blood have the advantages of specificity and stability, which could be used as disease biomarkers and potential bio-dosimeters to monitor the radiation risk. Based on this backgroud, circulating miRNAs were isolated from blood after Kunming mice were whole-body exposed to 300MeV/u carbon ion beam which were generated by the Heavy Ion Research Facility in Lanzhou (HIRFL), and the levels of miRNA expression were detected by miRNA PCR array. It was found that more than one hundred of circulating miRNAs were responded to carbon ion irradiation. Among these radiosensitive miRNAs, most of them were closely associated with immune system and hematopoietic system. The miRNA levels changed more than 2-fold were further verified by qRT-PCR analysis following exposure to X rays and iron ion beam. Some miRNAs such as let-7a, miR-34a, miR-223 and miR-150 showed obvious radio-sensitivity and dose-dependent effect, demonstrating that they were potential biomarkers of radiation and could be used as ideal bio-dosimeters. Those findings indicate that with the properties of high radio-sensitivity and time-saving quantification method by standard PCR assay, circulating miRNAs may become potential biomarkers for radiation detection in space exploration.

Genetic diminution of circulating prothrombin ameliorates multiorgan pathologies in sickle cell disease mice.

PubMed

Arumugam, Paritha I; Mullins, Eric S; Shanmukhappa, Shiva Kumar; Monia, Brett P; Loberg, Anastacia; Shaw, Maureen A; Rizvi, Tilat; Wansapura, Janaka; Degen, Jay L; Malik, Punam

2015-10-08

Sickle cell disease (SCD) results in vascular occlusions, chronic hemolytic anemia, and cumulative organ damage. A conspicuous feature of SCD is chronic inflammation and coagulation system activation. Thrombin (factor IIa [FIIa]) is both a central protease in hemostasis and a key modifier of inflammatory processes. To explore the hypothesis that reduced prothrombin (factor II [FII]) levels in SCD will limit vaso-occlusion, vasculopathy, and inflammation, we used 2 strategies to suppress FII in SCD mice. Weekly administration of FII antisense oligonucleotide "gapmer" to Berkeley SCD mice to selectively reduce circulating FII levels to ∼10% of normal for 15 weeks significantly diminished early mortality. More comprehensive, long-term comparative studies were done using mice with genetic diminution of circulating FII. Here, cohorts of FII(lox/-) mice (constitutively carrying ∼10% normal FII) and FII(WT) mice were tracked in parallel for a year following the imposition of SCD via hematopoietic stem cell transplantation. This genetically imposed suppression of FII levels resulted in an impressive reduction in inflammation (reduction in leukocytosis, thrombocytosis, and circulating interleukin-6 levels), reduced endothelial cell dysfunction (reduced endothelial activation and circulating soluble vascular cell adhesion molecule), and a significant improvement in SCD-associated end-organ damage (nephropathy, pulmonary hypertension, pulmonary inflammation, liver function, inflammatory infiltration, and microinfarctions). Notably, all of these benefits were achieved with a relatively modest 1.25-fold increase in prothrombin times, and in the absence of hemorrhagic complications. Taken together, these data establish that prothrombin is a powerful modifier of SCD-induced end-organ damage, and present a novel therapeutic target to ameliorate SCD pathologies. © 2015 by The American Society of Hematology.

Online tables of contents for books: effect on usage*

PubMed Central

Morris, Ruth C.

2001-01-01

Objectives: To explore whether the presence of online tables of contents (TOC) in an online catalog affects circulation (checkouts and inhouse usage). Two major questions were posed: (1) did the presence of online tables of contents for books increase use, and, (2) if it did, what factors might cause the increase? Method: A randomized and stratified design was used in tracking usage of 3,957 book titles that were previously divided into two groups: one with TOC and one without TOC. Stratification was done for year of imprint, location, subject, previous use, circulating or non-circulating status, and presence of TOC. The use was tracked by the online catalog statistics in the InnoPac online catalog for fourteen months. Results: The study found that tables of contents do increase usage. It also showed a correlation in the size of the effect based on the currency of the titles. In general, even after adjusting for all of the variables (publication date, location, circulation status, subject, and previous use), the odds of a title being used increased by 45% if the titles had online tables of contents, a statistically significant impact at the 0.05 level. Conclusions: This case-control study presents new information about the impact on circulation and inhouse use when tables of contents for books are added to the online catalog record. The study helps to establish the positive role of tables of contents in online catalogs. The research establishes TOC as a major parameter that can be successfully studied using quantitative methods. The study also provides information professionals with some guidance on when enhancement of TOC is likely to be most effective in increasing the use of existing collections. PMID:11209798

The relation between AMOC, gyre circulation, and meridional heat transports in the North Atlantic in model simulations of the last millennium

NASA Astrophysics Data System (ADS)

Jungclaus, J. H.; Moreno-Chamarro, E.; Lohmann, K.; Zanchettin, D.

2016-02-01

While it is clear that the Atlantic Meridional Overturning Circulation (AMOC) is responsible for meridional heat transfer from the South Atlantic and the tropics to the North Atlantic, the majority of the heat transport in the northern North Atlantic and the Nordic seas is carried by the gyre system. However, the detailed mechanisms determining the interaction between and the temporal modulation of the components of the northward heat transport system are not clear. Long-term climate records and model simulations can help to identify important processes and to provide background for the changes that are presently observed. Multi-centennial proxy records from the subpolar North Atlantic and the Nordic Seas indicate, for example, an out-of-phase behavior of sea surface temperature and gyre circulation between the two regions with consequences for regional climate. Paleoceanographic evidence from Fram Strait shows a pronounced modulation of heat transfer to the Arctic by the Atlantic Water layer during the last 2000 years and reconstructions from the Subpolar North Atlantic suggest a role of ocean circulation in the transition between the Medieval Climate Anomaly and the Little Ice Age. Here we explore a small ensemble of last millennium simulations, carried out with the Max Planck Institute Earth System Model, and analyze mechanisms connecting the AMOC and gyre circulation and their relation to external forcing. Our results support the important role of the Subpolar Gyre strength and the related meridional mass and temperature fluxes. We find that the modulation of the northward heat transport into the Nordic Seas and the Arctic has pronounced impact on sea-ice distribution, ocean-atmosphere interaction, and the surface climate in Scandinavia and Western Europe.

The relation between AMOC, gyre circulation, and meridional heat transports in the North Atlantic in model simulations of the last millennium

NASA Astrophysics Data System (ADS)

Jungclaus, Johann; Moreno-Chamarro, Eduardo; Lohmann, Katja

2016-04-01

While it is clear that the Atlantic Meridional Overturning Circulation (AMOC) is responsible for meridional heat transfer from the South Atlantic and the tropics to the North Atlantic, the majority of the heat transport in the northern North Atlantic and the Nordic seas is carried by the gyre system. However, the detailed mechanisms determining the interaction between and the temporal modulation of the components of the northward heat transport system are not clear. Long-term climate records and model simulations can help to identify important processes and to provide background for the changes that are presently observed. Multi-centennial proxy records from the subpolar North Atlantic and the Nordic Seas indicate, for example, an out-of-phase behavior of sea surface temperature and gyre circulation between the two regions with consequences for regional climate. Paleoceanographic evidence from Fram Strait shows a pronounced modulation of heat transfer to the Arctic by the Atlantic Water layer during the last 2000 years and reconstructions from the Subpolar North Atlantic suggest a role of ocean circulation in the transition between the Medieval Climate Anomaly and the Little Ice Age. Here we explore a small ensemble of last millennium simulations, carried out with the Max Planck Institute Earth System Model, and analyze mechanisms connecting the AMOC and gyre circulation and their relation to external forcing. Our results support the important role of the Subpolar Gyre strength and the related meridional mass and temperature fluxes. We find that the modulation of the northward heat transport into the Nordic Seas and the Arctic has pronounced impact on sea-ice distribution, ocean-atmosphere interaction, and the surface climate in Scandinavia and Western Europe.

MicroRNA-939 governs vascular integrity and angiogenesis through targeting γ-catenin in endothelial cells

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hou, Shiqiang; Fang, Ming; Zhu, Qian

Coronary collateral circulation (CCC) functions as a natural bypass in the event of coronary obstruction, which markedly improves prognosis in patients with coronary artery disease (CAD). MicroRNAs (miRNAs) have been implicated in multiple physiological and pathological processes, including angiogenesis involved in CCC growth. The roles that miRNA-939 (miR-939) plays in angiogenesis remain largely unknown. We conducted this study to explore the expression of miR-939 in CAD patients and its role in angiogenesis. For the first time, our results indicated that the expression of circulating miR-939 was down-regulated in patients with sufficient CCC compared with patients with poor CCC. Overexpression ofmore » miR-939 in primary human umbilical vein endothelial cells (HUVECs) significantly inhibited the proliferation, adhesion and tube formation, but promoted the migration of cells. In contrast, miR-939 knockdown exerted reverse effects. We further identified that γ-catenin was a novel target of miR-939 by translational repression, which could rescue the effects of miR-939 in HUVECs. In summary, this study revealed that the expression of circulating miR-939 was down-regulated in CAD patients with sufficient CCC. MiR-939 abolished vascular integrity and repressed angiogenesis through directly targeting γ-catenin. It provided a potential biomarker and a therapeutic target for CAD. - Highlights: • Circulating miR-939 is decreased in sufficient coronary collateral circulation. • MiR-939 abolishes vascular integrity in endothelial cells. • MiR-939 represses angiogenesis. • γ-catenin is a novel target of miR-939.« less

Online tables of contents for books: effect on usage.

PubMed

Morris, R C

2001-01-01

To explore whether the presence of online tables of contents (TOC) in an online catalog affects circulation (checkouts and inhouse usage). Two major questions were posed: (1) did the presence of online tables of contents for books increase use, and, (2) if it did, what factors might cause the increase? A randomized and stratified design was used in tracking usage of 3,957 book titles that were previously divided into two groups: one with TOC and one without TOC. Stratification was done for year of imprint, location, subject, previous use, circulating or non-circulating status, and presence of TOC. The use was tracked by the online catalog statistics in the InnoPac online catalog for fourteen months. The study found that tables of contents do increase usage. It also showed a correlation in the size of the effect based on the currency of the titles. In general, even after adjusting for all of the variables (publication date, location, circulation status, subject, and previous use), the odds of a title being used increased by 45% if the titles had online tables of contents, a statistically significant impact at the 0.05 level. This case-control study presents new information about the impact on circulation and inhouse use when tables of contents for books are added to the online catalog record. The study helps to establish the positive role of tables of contents in online catalogs. The research establishes TOC as a major parameter that can be successfully studied using quantitative methods. The study also provides information professionals with some guidance on when enhancement of TOC is likely to be most effective in increasing the use of existing collections.

Optimizing Aerobot Exploration of Venus

NASA Astrophysics Data System (ADS)

Ford, Kevin S.

1997-03-01

Venus Flyer Robot (VFR) is an aerobot; an autonomous balloon probe designed for remote exploration of Earth's sister planet in 2003. VFR's simple navigation and control system permits travel to virtually any location on Venus, but it can survive for only a limited duration in the harsh Venusian environment. To help address this limitation, we develop: (1) a global circulation model that captures the most important characteristics of the Venusian atmosphere; (2) a simple aerobot model that captures thermal restrictions faced by VFR at Venus; and (3) one exact and two heuristic algorithms that, using abstractions (1) and (2), construct routes making the best use of VFR's limited lifetime. We demonstrate this modeling by planning several small example missions and a prototypical mission that explores numerous interesting sites recently documented in the plane tary geology literature.

Optimizing Aerobot Exploration of Venus

NASA Technical Reports Server (NTRS)

Ford, Kevin S.

1997-01-01

Venus Flyer Robot (VFR) is an aerobot; an autonomous balloon probe designed for remote exploration of Earth's sister planet in 2003. VFR's simple navigation and control system permits travel to virtually any location on Venus, but it can survive for only a limited duration in the harsh Venusian environment. To help address this limitation, we develop: (1) a global circulation model that captures the most important characteristics of the Venusian atmosphere; (2) a simple aerobot model that captures thermal restrictions faced by VFR at Venus; and (3) one exact and two heuristic algorithms that, using abstractions (1) and (2), construct routes making the best use of VFR's limited lifetime. We demonstrate this modeling by planning several small example missions and a prototypical mission that explores numerous interesting sites recently documented in the plane tary geology literature.

The Politics of PISA: The Media, Policy and Public Responses in Norway and England

ERIC Educational Resources Information Center

Hopfenbeck, Therese N.; Görgen, Kristine

2017-01-01

Using the PISA 2015 releases in Norway and England, this article explores how PISA has been presented in the media and how the policy level has responded to the results. England will be used as an example for comparison. The article presents early media responses from the 20 most circulated daily newspapers in the two countries and discusses them…

Elucidating Dynamical Processes Relevant to Flow Encountering Abrupt Topography (FLEAT)

DTIC Science & Technology

2015-09-30

Encountering Abrupt Topography (FLEAT) Bo Qiu Dept of Oceanography, University of Hawaii at Manoa 1000 Pope Rd. Honolulu, HI 96822 phone: (808) 956...c) to explore relevant dynamics by using both simplified models and OGCM output with realistic topography and surface boundary conditions...scale abyssal circulation, we propose to use the Hallberg Isopycnal Model (HIM). The HIM allows sloping isopycnals to interact with bottom topography

The Story of Blue Pee: Ignorance and a New Mode of Governing in Contemporary Japan

ERIC Educational Resources Information Center

Konishi, Yoshiko

2009-01-01

This paper explores a change in a mode of governing in Japan during the administration of Prime Minister Junichiro Koizumi (2001-2006) through an examination of what I call the story of blue pee. The story circulated among people engaged in implementing child welfare policies at the local level, and implied that mothers today were ignorant in the…

A six-legged rover for planetary exploration

NASA Technical Reports Server (NTRS)

Simmons, Reid; Krotkov, Eric; Bares, John

1991-01-01

To survive the rigors and isolation of planetary exploration, an autonomous rover must be competent, reliable, and efficient. This paper presents the Ambler, a six-legged robot featuring orthogonal legs and a novel circulating gait, which has been designed for traversal of rugged, unknown environments. An autonomous software system that integrates perception, planning, and real-time control has been developed to walk the Ambler through obstacle strewn terrain. The paper describes the information and control flow of the walking system, and how the design of the mechanism and software combine to achieve competent walking, reliable behavior in the face of unexpected failures, and efficient utilization of time and power.

Colonial scientific-medical documentary films and the legitimization of an ideal state in post-war Spain.

PubMed

Tabernero, Carlos; Jiménez-Lucena, Isabel; Molero-Mesa, Jorge

2017-01-01

This paper explores the role of film and medical-health practices and discourses in the building and legitimating strategies of Franco's fascist regime in Spain. The analysis of five medical-colonial documentary films produced during the 1940s explores the relationship between mass media communication practices and techno-scientific knowledge production, circulation and management processes. These films portray a non-problematic colonial space where social order is articulated through scientific-medical practices and discourses that match the regime's need to consolidate and legitimize itself while asserting the inclusion-exclusion dynamics involved in the definition of social prototypes through processes of medicalization.

Heterogeneity of the North Atlantic oceanic lithosphere based on integrated analysis of GOCE satellite gravity and geological data

NASA Astrophysics Data System (ADS)

Barantseva, Olga; Artemieva, Irina; Thybo, Hans; Herceg, Matija

2015-04-01

We present the results from modelling the gravity and density structure of the upper mantle for the off-shore area of the North Atlantic region. The crust and upper mantle of the region is expected to be anomalous: Part of the region affected by the Icelandic plume has an anomalously shallow bathymetry, whereas the northern part of the region is characterized by ultraslow spreading. In order to understand the links between deep geodynamical processes that control the spreading rate, on one hand, and their manifestations such as oceanic floor bathymetry and heat flow, on the other hand, we model the gravity and density structure of the upper mantle from satellite gravity data. The calculations are based on interpretation of GOCE gravity satellite data for the North Atlantics. To separate the gravity signal responsible for density anomalies within the crust and upper mantle, we subtract the lower harmonics caused by deep density structure of the Earth (the core and the lower mantle). The gravity effect of the upper mantle is calculated by subtracting the gravity effect of the crust for two crustal models. We use a recent regional seismic model for the crustal structure (Artemieva and Thybo, 2013) based om seismic data together with borehole data for sediments. For comparison, similar results are presented for the global CRUST 1.0 model as well (Laske, 2013). The conversion of seismic velocity data for the crustal structure to crustal density structure is crucial for the final results. We use a combination of Vp-to-density conversion based on published laboratory measurements for the crystalline basement (Ludwig, Nafe, Drake, 1970; Christensen and Mooney, 1995) and for oceanic sediments and oceanic crust based on laboratory measurements for serpentinites and gabbros from the Mid-Atlantic Ridge (Kelemen et al., 2004). Also, to overcome the high degree of uncertainty in Vp-to-density conversion, we account for regional tectonic variations in the Northern Atlantics as constrained by numerous published seismic profiles and potential-field models across the Norwegian off-shore crust (e.g. Breivik et al., 2005, 2007). The results demonstrate the presence of strong gravity and density heterogeneity of the upper mantle in the North Atlantic region. In particular, there is a sharp contrast at the continent-ocean transition, which also allows for recognising mantle gravity anomalies associated with continental fragments and with anomalous oceanic lithosphere.

A 3D, finite element model for baroclinic circulation on the Vancouver Island continental shelf

USGS Publications Warehouse

Walters, R.A.; Foreman, M.G.G.

1992-01-01

This paper describes the development and application of a 3-dimensional model of the barotropic and baroclinic circulation on the continental shelf west of Vancouver Island, Canada. A previous study with a 2D barotropic model and field data revealed that several tidal constituents have a significant baroclinic component (the K1 in particular). Thus we embarked on another study with a 3D model to study the baroclinic effects on the residual and several selected tidal constituents. The 3D model uses a harmonic expansion in time and a finite element discretization in space. All nonlinear terms are retained, including quadratic bottom stress, advection and wave transport (continuity nonlinearity). The equations are solved as a global and a local problem, where the global problem is the solution of the wave equation formulation of the shallow water equations, and the local problem is the solution of the momentum equation for the vertical velocity profile. These equations are coupled to the advection-diffusion equation for density so that density gradient forcing is included in the momentum equations. However, the study presented here describes diagnostic calculations for the baroclinic residual circulation only. The model is sufficiently efficient that it encourages sensitivity testing with a large number of model runs. In this sense, the model is akin to an extension of analytical solutions to the domain of irregular geometry and bottom topography where this parameter space can be explored in some detail. In particular, the consequences of the sigma coordinate system used by the model are explored. Test cases using an idealized representation of the continental shelf, shelf break and shelf slope, lead to an estimation of the velocity errors caused by interpolation errors inherent in the sigma coordinate system. On the basis of these estimates, the computational grid used in the 2D model is found to have inadequate resolution. Thus a new grid is generated with increased accuracy in the region of the shelf break. However, even with increased resolution, spurious baroclinic circulation seaward of the shelf break and in the vicinity of Juan de Fuca canyon remained a significant problem when the pressure gradient terms were evaluated using the ?? coordinate system and using a realistic density profile. With the new grid, diagnostic calculations of the barotropic and baroclinic residual circulation are performed using forcing from the observed ??t (density) field and from the gradient of this field. ?? 1992.

Chicken egg yolk antibodies (IgY) for detecting circulating antigens of Schistosoma japonicum.

PubMed

Cai, Yu-Chun; Guo, Jian; Chen, Shao-Hong; Tian, Li-Guang; Steinmann, Peter; Chen, Mu-Xin; Li, Hao; Ai, Lin; Chen, Jia-Xu

2012-09-01

IgY isolated from egg yolk has been widely used in immunodiagnostic tests, including tests to detect circulating antigen (soluble egg antigen or SEA) of Schistosoma japonicum. A sandwich ELISA was established using a combination of anti-S. japonicum SEA-IgY polyclonal antibodies and IgM monoclonal antibodies. To explore sensitivity and specificity of the sandwich ELISA, serum samples from 43 patients infected with S. japonicum were tested. All acute cases and 91.3% of the chronic cases showed a positive reaction. Only 5% of the control sera from healthy persons gave a positive response. Cross-reactions with antibodies to nine other parasites were rare. The developed immunoassay is reasonably sensitive and specific. It could be used for field research and treatment efficacy assessments. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

Venus's winds and temperatures during the MESSENGER's flyby: An approximation to a three-dimensional instantaneous state of the atmosphere

NASA Astrophysics Data System (ADS)

Peralta, J.; Lee, Y. J.; Hueso, R.; Clancy, R. T.; Sandor, B. J.; Sánchez-Lavega, A.; Lellouch, E.; Rengel, M.; Machado, P.; Omino, M.; Piccialli, A.; Imamura, T.; Horinouchi, T.; Murakami, S.; Ogohara, K.; Luz, D.; Peach, D.

2017-04-01

Even though many missions have explored the Venus atmospheric circulation, its instantaneous state is poorly characterized. In situ measurements vertically sampling the atmosphere exist for limited locations and dates, while remote sensing observations provide only global averages of winds at altitudes of the clouds: 47, 60, and 70 km. We present a three-dimensional global view of Venus's atmospheric circulation from data obtained in June 2007 by the MErcury Surface, Space ENvironment, GEochemistry, and Ranging (MESSENGER) and Venus Express spacecrafts, together with ground-based observations. Winds and temperatures were measured for heights 47-110 km from multiwavelength images and spectra covering 40°N-80°S and local times 12 h-21 h. Dayside westward winds exhibit day-to-day changes, with maximum speeds ranging 97-143 m/s and peaking at variable altitudes within 75-90 km, while on the nightside these peak below cloud tops at ˜60 km. Our results support past reports of strong variability of the westward zonal superrotation in the transition region, and good agreement is found above the clouds with results from the Laboratoire de Météorologie Dynamique (LMD) Venus general circulation model.

External forcing as a metronome for Atlantic multidecadal variability

NASA Astrophysics Data System (ADS)

Otterå, Odd Helge; Bentsen, Mats; Drange, Helge; Suo, Lingling

2010-10-01

Instrumental records, proxy data and climate modelling show that multidecadal variability is a dominant feature of North Atlantic sea-surface temperature variations, with potential impacts on regional climate. To understand the observed variability and to gauge any potential for climate predictions it is essential to identify the physical mechanisms that lead to this variability, and to explore the spatial and temporal characteristics of multidecadal variability modes. Here we use a coupled ocean-atmosphere general circulation model to show that the phasing of the multidecadal fluctuations in the North Atlantic during the past 600 years is, to a large degree, governed by changes in the external solar and volcanic forcings. We find that volcanoes play a particularly important part in the phasing of the multidecadal variability through their direct influence on tropical sea-surface temperatures, on the leading mode of northern-hemisphere atmosphere circulation and on the Atlantic thermohaline circulation. We suggest that the implications of our findings for decadal climate prediction are twofold: because volcanic eruptions cannot be predicted a decade in advance, longer-term climate predictability may prove challenging, whereas the systematic post-eruption changes in ocean and atmosphere may hold promise for shorter-term climate prediction.

Cellular and physiological mechanisms underlying blood flow regulation in the retina choroid in health disease

PubMed Central

Kur, Joanna; Newman, Eric A.; Chan-Ling, Tailoi

2012-01-01

We review the cellular and physiological mechanisms responsible for the regulation of blood flow in the retina and choroid in health and disease. Due to the intrinsic light sensitivity of the retina and the direct visual accessibility of fundus blood vessels, the eye offers unique opportunities for the non-invasive investigation of mechanisms of blood flow regulation. The ability of the retinal vasculature to regulate its blood flow is contrasted with the far more restricted ability of the choroidal circulation to regulate its blood flow by virtue of the absence of glial cells, the markedly reduced pericyte ensheathment of the choroidal vasculature, and the lack of intermediate filaments in choroidal pericytes. We review the cellular and molecular components of the neurovascular unit in the retina and choroid, techniques for monitoring retinal and choroidal blood flow, responses of the retinal and choroidal circulation to light stimulation, the role of capillaries, astrocytes and pericytes in regulating blood flow, putative signaling mechanisms mediating neurovascular coupling in the retina, and changes that occur in the retinal and choroidal circulation during diabetic retinopathy, age-related macular degeneration, glaucoma, and Alzheimer's disease. We close by discussing issues that remain to be explored. PMID:22580107

Marli: Mars Lidar for Global Wind Profiles and Aerosol Profiles from Orbit

NASA Technical Reports Server (NTRS)

Abshire, J. B.; Guzewich, S. D.; Smith, M. D.; Riris, H.; Sun, X.; Gentry, B. M.; Yu, A.; Allan, G. R.

2016-01-01

The Mars Exploration Analysis Group's Next Orbiter Science Analysis Group (NEXSAG) has recently identified atmospheric wind measurements as one of 5 top compelling science objectives for a future Mars orbiter. To date, only isolated lander observations of martian winds exist. Winds are the key variable to understand atmospheric transport and answer fundamental questions about the three primary cycles of the martian climate: CO2, H2O, and dust. However, the direct lack of observations and imprecise and indirect inferences from temperature observations leave many basic questions about the atmospheric circulation unanswered. In addition to addressing high priority science questions, direct wind observations from orbit would help validate 3D general circulation models (GCMs) while also providing key input to atmospheric reanalyses. The dust and CO2 cycles on Mars are partially coupled and their influences on the atmospheric circulation modify the global wind field. Dust absorbs solar infrared radiation and its variable spatial distribution forces changes in the atmospheric temperature and wind fields. Thus it is important to simultaneously measure the height-resolved wind and dust profiles. MARLI provides a unique capability to observe these variables continuously, day and night, from orbit.

Experimental Myocardial Infarction Upregulates Circulating Fibroblast Growth Factor‐23

PubMed Central

Andrukhova, Olena; Slavic, Svetlana; Odörfer, Kathrin I; Erben, Reinhold G

2015-01-01

ABSTRACT Myocardial infarction (MI) is a major cause of death worldwide. Epidemiological studies have linked vitamin D deficiency to MI incidence. Because fibroblast growth factor‐23 (FGF23) is a master regulator of vitamin D hormone production and has been shown to be associated with cardiac hypertrophy per se, we explored the hypothesis that FGF23 may be a previously unrecognized pathophysiological factor causally linked to progression of cardiac dysfunction post‐MI. Here, we show that circulating intact Fgf23 was profoundly elevated, whereas serum vitamin D hormone levels were suppressed, after induction of experimental MI in rat and mouse models, independent of changes in serum soluble Klotho or serum parathyroid hormone. Both skeletal and cardiac expression of Fgf23 was increased after MI. Although the molecular link between the cardiac lesion and circulating Fgf23 concentrations remains to be identified, our study has uncovered a novel heart–bone–kidney axis that may have important clinical implications and may inaugurate the new field of cardio‐osteology. © 2015 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals, Inc. on behalf of American Society for Bone and Mineral Research (ASBMR). PMID:25858796

Circulating MicroRNAs as Biomarkers in Biliary Tract Cancers

PubMed Central

Letelier, Pablo; Riquelme, Ismael; Hernández, Alfonso H.; Guzmán, Neftalí; Farías, Jorge G.; Roa, Juan Carlos

2016-01-01

Biliary tract cancers (BTCs) are a group of highly aggressive malignant tumors with a poor prognosis. The current diagnosis is based mainly on imaging and intraoperative exploration due to brush cytology havinga low sensitivity and the standard markers, such as carcinoembryonic antigen (CEA) and carbohydrate 19-9 (CA19-9), not having enough sensitivity nor specificity to be used in a differential diagnosis and early stage detection. Thus, better non-invasive methods that can distinguish between normal and pathological tissue are needed. MicroRNAs (miRNAs) are small, single-stranded non-coding RNA molecules of ~20–22 nucleotides that regulate relevant physiological mechanisms and can also be involved in carcinogenesis. Recent studies have demonstrated that miRNAs are detectable in multiple body fluids, showing great stability, either free or trapped in circulating microvesicles, such as exosomes. miRNAs are ideal biomarkers that may be used in screening and prognosis in biliary tract cancers, aiding also in the clinical decisions at different stages of cancer treatment. This review highlights the progress in the analysis of circulating miRNAs in serum, plasma and bile as potential diagnostic and prognostic markers of BTCs. PMID:27223281

[Study on material basis of essential oil from Yin Teng Gu Bi Kang prescription on activating blood circulation].

PubMed

Wang, Yuan-Qing; Yan, Jian-Ye; Gong, Li-Min; Luo, Kun; Li, Shun-Xiang; Yang, Yan-Tao; Xie, Yu

2014-08-01

To explore the component difference of the serum containing essential oil from Yin Teng Gu Bi Kang prescription in pathologic and physiologic rat models, and to reveal the material basis of its efficacy of activating blood circulation. The essential oils were obtained by CO2 supercritical fluid extraction and the ingredients of the essential oils in vitro and in vivo (under physiological and pathological status) were analyzed by GC-MS to compare differences of the essential oil under physiological and pathological status in rats. 32 components were identified with the main components of Z-ligustilide (39.23%) and d-limonene (21.7%) in the essential oil. In vivo analysis on the essential oil indicated that 16 components were identified, 7 existed originally in essential oil and 9 were metabolites under physiological status; while 22 components were identified, 10 existed originally in essential oil and 12 were metabolites under pathological status (acute blood stasis). There were 7 common prototypes and 8 common metabolites under different physiological status. The absorption and metabolism of essential oils were affected by blood stasis and the compounds migrating to blood may be the effective substance in activating blood circulation.

Angiopoietin-like protein 8/betatrophin as a new determinant of type 2 diabetes remission after bariatric surgery.

PubMed

Ejarque, Miriam; Borlaug, Marianne; Vilarrasa, Nuria; Martinez-Perez, Bruno; Llauradó, Gemma; Megía, Ana; Helland, Thomas; Gutierrez, Cristina; Serena, Carolina; Folkestad, Oddry; Nuñez-Roa, Catalina; Roche, Kelly; Casajoana, Ana; Fradera, Rosa; González-Clemente, José Miguel; López, Miguel; Mohn, Arne C; Nedrebø, Bjørn G; Nogueiras, Ruben; Mellgren, Gunnar; Fernø, Johan; Fernández-Veledo, Sonia; Vendrell, Joan

2017-06-01

This work aimed to explore the link between angiopoietin-like protein 8 (ANGPTL8) and weight loss after metabolic surgery. In the cross-sectional study (n = 100), circulating ANGPTL8 concentrations were significantly lower in morbidly obese than in lean subjects, and strikingly lower in morbidly obese patients with type 2 diabetes mellitus (T2DM). Conversely, ANGPTL8 expression in subcutaneous adipose tissue (SAT) was higher in morbidly obese patients, particularly in those with T2DM, whereas its expression in visceral adipose tissue was unchanged. The main predictors for circulating levels of ANGPTL8 were BMI and T2DM, whereas ANGPTL8 expression in SAT was determined by the presence of T2DM. The prospective cohort studies before and 1 year after bariatric surgery in morbidly obese patients with (n = 45) and without (n = 30) T2DM, revealed a significant increase of circulating ANGPTL8 levels 1 year after the bariatric surgery. Intriguingly, this increment, which was predicted by basal ANGPTL8 concentrations, appeared as a determinant of T2DM remission. In conclusion, circulating ANGPTL8 levels have an inverse relationship with SAT expression. Low basal levels of ANGPTL8 rebound after bariatric surgery. The increment in ANGPTL8 concentrations at 1 month of follow-up after weight loss emerged as a significant predictor of the T2DM remission at 1 year of follow-up. Copyright © 2017 Elsevier Inc. All rights reserved.

West Florida shelf circulation and temperature budget for the 1998 fall transition

NASA Astrophysics Data System (ADS)

He, Ruoying; Weisberg, Robert H.

2003-05-01

Mid-latitude continental shelves undergo a fall transition as the net heat flux changes from warming to cooling. Using in situ data and a numerical model we investigate the circulation on the west Florida shelf (WFS) for the fall transition of 1998. The model is a regional adaptation of the primitive equation, Princeton Ocean Model forced by NCEP reanalysis wind, air pressure, and heat flux fields, plus river inflows. After comparison with observations the model is used to draw inferences on the seasonal and synoptic scale features of the shelf circulation. By running twin experiments, one without and the other with an idealized Loop Current (LC), we explore the relative importance of local versus deep-ocean forcing. We find that local forcing largely controls the inner-shelf circulation, including changes from the Florida Panhandle in the north to regions farther south. The effects of the LC in fall 1998 are to reinforce the mid-shelf currents and to increase the across-shelf transports in the bottom Ekman layer, thereby accentuating the shoreward transport of cold, nutrient rich water of deep-ocean origin. A three-dimensional analysis of the temperature budget reveals that surface heat flux largely controls both the seasonal and synoptic scale temperature variations. Surface cooling leads to convective mixing that rapidly alters temperature gradients. One interesting consequence is that upwelling can result in near-shore warming as warmer offshore waters are advected landward. The temperature balances on the shelf are complex and fully three-dimensional.

Hybrid Atom Electrostatic System for Satellite Geodesy

NASA Astrophysics Data System (ADS)

Zahzam, Nassim; Bidel, Yannick; Bresson, Alexandre; Huynh, Phuong-Anh; Liorzou, Françoise; Lebat, Vincent; Foulon, Bernard; Christophe, Bruno

2017-04-01

The subject of this poster comes within the framework of new concepts identification and development for future satellite gravity missions, in continuation of previously launched space missions CHAMP, GRACE, GOCE and ongoing and prospective studies like NGGM, GRACE 2 or E-GRASP. We were here more focused on the inertial sensors that complete the payload of such satellites. The clearly identified instruments for space accelerometry are based on the electrostatic technology developed for many years by ONERA and that offer a high level of performance and a high degree of maturity for space applications. On the other hand, a new generation of sensors based on cold atom interferometry (AI) is emerging and seems very promising in this context. These atomic instruments have already demonstrated on ground impressive results, especially with the development of state-of-the-art gravimeters, and should reach their full potential only in space, where the microgravity environment allows long interaction times. Each of these two types of instruments presents their own advantages which are, for the electrostatic sensors (ES), their demonstrated short term sensitivity and their high TRL, and for AI, amongst others, the absolute nature of the measurement and therefore no need for calibration processes. These two technologies seem in some aspects very complementary and a hybrid sensor bringing together all their assets could be the opportunity to take a big step in this context of gravity space missions. We present here the first experimental association on ground of an electrostatic accelerometer and an atomic accelerometer and underline the interest of calibrating the ES instrument with the AI. Some technical methods using the ES proof-mass as the Raman Mirror seem very promising to remove rotation effects of the satellite on the AI signal. We propose a roadmap to explore further in details and more rigorously this attractive hybridization scheme in order to assess its potential for a future geodesy space mission with theoretical and experimental work.

Dynamic Heights in the Great Lakes at Different Epochs

NASA Astrophysics Data System (ADS)

Roman, D. R.

2016-12-01

Vertical control in the Great Lakes region is currently defined by the International Great Lakes Datum of 1985 (IGLD 85) in the form of dynamic heights. Starting in 2025, dynamic heights will be defined through GNSS-derived geometric coordinates and a geopotential model. This paper explores the behavior of an existing geopotential model at different epochs when the Great Lakes were at significantly different (meter-level) geopotential surfaces. Water surfaces were examined in 2015 and 2010 at six sites on Lakes Superior and Lake Erie (three on each Lake). These sites have collocated a Continuously Operating Reference Station (CORS) and a Water Level Sensor (WLS). The offset between the antenna phase center for the CORS and the WLS datum are known at each site. The WLS then measures the distance from its datum to the Lake surface via an open well. Thus it is possible to determine the height above an ellipsoid datum at these sites as long as both the CORS and WLS are operational. The geometric coordinates are then used to estimate the geopotential value from the xGEOID16B model. This accomplished in two steps. To provide an improved reference model, EGM2008 was spectrally enhanced using observations from the GOCE satellite gravity mission and aerogravity from the Gravity for the Redefinition of the American Vertical Datum (GRAV-D) Project. This enhanced model, xGEOID16B_Ref, is still only a five arcminute resolution model (d/o 2160), but resolves dynamic heights at about 2 cm on Lake Superior for December 2015. The reference model was primarily developed to determine a one arcminute geoid height grid, xGEOID16B, available on the NGS website. This geoid height model was used to iteratively develop improved geopotential value for each of the site locations, which then improved comparisons to the cm-level. Comparisons were then made at the 2010 epoch for these same locations to determine if the performance of the geopotential model was consistent.

e.motion - European Initiatives for a Future Gravity Field Mission

NASA Astrophysics Data System (ADS)

Gruber, T.

2017-12-01

Since 2010 a large team of European scientists, with the support of technological and industrial partners, is preparing proposals for new gravity field missions as follow-up to GRACE, GOCE and GRACE-FO. The main goal of the proposed mission concepts is the long term observation of the time variable gravity field with significantly increased spatial and temporal resolution as it can be performed nowadays with GRACE or in the near future with GRACE Follow-On. These observations are crucial for long term monitoring of mass variations in the system Earth in order to improve our knowledge about the global and regional water cycle as well as about processes of the solid Earth. Starting from the existing concepts of single pair mission like GRACE and GRACE-FO, sensitivity, spatial and temporal resolution shall be increased, such that also smaller scale time variable signals can be resolved, which cannot be detected with the current techniques. For such a mission concept new and significantly improved observation techniques are needed. This concerns in particular the measurement of inter-satellite distances, the observation of non-gravitational accelerations, the configuration of the satellite orbit and most important the implementation of constellation of satellite pairs. All in all three proposals have been prepared by the e.motion team specifying in detail the mission design and the performance in terms of science applications. Starting with a single-pair pendulum mission, which was proposed for ESA's Earth Explorer 8 call (EE8), more recently a double-pair Bender-type mission was proposed for the ESA's EE9 call. In between several studies on European (DLR and ESA) and inter-agency level (ESA-NASA) have been performed. The presentation provides a summary about all these initiatives, derives some conclusions which can be drawn from the mission proposals and study results and gives an outlook about future initiatives for gravity field missions in Europe.

Mapping the gravity field in coastal areas: feasibility and interest of a new airborne planar gradiometer concept

NASA Astrophysics Data System (ADS)

Douch, Karim; Panet, Isabelle; Foulon, Bernard; Christophe, Bruno; Pajot-Métivier, Gwendoline; Diament, Michel

2014-05-01

Satellite missions such as CHAMP, GRACE and GOCE have led to an unprecedented improvement of global gravity field models during the past decade. However, for many applications these global models are not sufficiently accurate when dealing with wavelengths shorter than 100 km. This is all the more true in areas where gravity data are scarce and uneven as for instance in the poorly covered land-sea transition area. We suggest here, in line with spatial gravity gradiometry, airborne gravity gradiometry as a convenient way to amplify the sensitivity to short wavelengths and to cover homogeneously coastal region. Moreover, the directionality of the gravity gradients gives new information on the geometry of the gravity field and therefore of the causative bodies. In this respect, we analyze here the performances of a new airborne electrostatic acceleration gradiometer, GREMLIT, which permits along with ancillary measurements to determine the horizontal gradients of the horizontal components of the gravitational field in the instrumental frame. GREMLIT is composed of a compact assembly of 4 planar electrostatic accelerometers inheriting from technologies developed by ONERA for spatial accelerometers. After an overview of the functionals of the gravity field that are of interest for coastal oceanography, passive navigation and hydrocarbon exploration, we present the corresponding required precision and resolution. Then, we investigate the influence of the different parameters of the survey, such as altitude or cross-track distance, on the resolution and precision of the final measurements. To do so, we design numerical simulations of airborne survey performed with GREMLIT and compute the total error budget on the gravity gradients. Based on this error analysis, we infer by a method of error propagation the uncertainty on the different functionals of the gravity potential used for each application. This finally enables us to conclude on the requirements for a high resolution mapping of the gravity field in coastal areas.

"To Veil the Threat of Terror": Afghan Women and the in the Imagery of the U.S. War on Terrorism

ERIC Educational Resources Information Center

Cloud, Dana L.

2004-01-01

This article explores the role of widely circulated images of Afghan people in building public support for the 2001-2002 U.S. war with Afghanistan. Emphasizing images of women, I argue that these representations participate in the more general category of "the clash of civilizations," which constitutes a verbal and a visual ideograph linked to the…

Comparisons of the effect of naturally acquired maternal pertussis antibodies and antenatal vaccination induced maternal tetanus antibodies on infant's antibody secreting lymphocyte responses and circulating plasma antibody

USDA-ARS?s Scientific Manuscript database

The goal of this study was to explore the effects of trans-placental tetanus toxoid (TT) and pertussis (PT) antibodies on an infant's response to vaccination in the context of antenatal immunization with tetanus but not with pertussis. 38 mothers received a single dose of TT vaccine during pregnancy...

Interaction of methylation-related genetic variants with circulating fatty acids on plasma lipids: a meta-analysis of 7 studies & methylation analysis of 3 studies in the Cohorts for Heart & Aging Research

USDA-ARS?s Scientific Manuscript database

Background: DNA methylation is influenced by diet and single nucleotide polymorphisms (SNPs), and methylation modulates gene expression. Objective: We aimed to explore whether the gene-by-diet interactions on blood lipids act through DNA methylation. Design: We selected 7 SNPs on the basis of predic...

"Romantic", "Classic" and "Baroque" Views of Nature: An Analysis of Pictures about the Environment in Greek Primary School Textbooks--Diachronic Considerations

ERIC Educational Resources Information Center

Lemoni, Rea; Stamou, Anastasia G.; Stamou, George P.

2011-01-01

Taking the view that pictures are not a transparent but rather a deforming mirror of reality, shaping representations of the world bound up with the interests of the social institutions within which pictures are circulated and read, our aim is to explore what view of nature and of the human-nature relationship is built in Greek natural science…

The hydrodynamic and ultrasound-induced forces on microbubbles under high Reynolds number flow representative of the human systemic circulation

NASA Astrophysics Data System (ADS)

Clark, Alicia; Aliseda, Alberto

2016-11-01

Ultrasound contrast agents (UCAs) are micron-sized bubbles that are used in conjunction with ultrasound (US) in medical applications such as thrombolysis and targeted intravenous drug delivery. Previous work has shown that the Bjerknes force, due to the phase difference between the incoming US pressure wave and the bubble volume oscillations, can be used to manipulate the trajectories of microbubbles. Our work explores the behavior of microbubbles in medium sized blood vessels under both uniform and pulsatile flows at a range of physiologically relevant Reynolds and Womersley numbers. High speed images were taken of the microbubbles in an in-vitro flow loop that replicates physiological flow conditions. During the imaging, the microbubbles were insonified at different diagnostic ultrasound settings (varying center frequency, PRF, etc.). An in-house Lagrangian particle tracking code was then used to determine the trajectories of the microbubbles and, thus, a dynamic model for the microbubbles including the Bjerknes forces acting on them, as well as drag, lift, and added mass. Preliminary work has also explored the behavior of the microbubbles in a patient-specific model of a carotid artery bifurcation to demonstrate the feasibility of preferential steering of microbubbles towards the intracranial circulation with US.

SST-Forced Seasonal Simulation and Prediction Skill for Versions of the NCEP/MRF Model.

NASA Astrophysics Data System (ADS)

Livezey, Robert E.; Masutani, Michiko; Jil, Ming

1996-03-01

The feasibility of using a two-tier approach to provide guidance to operational long-lead seasonal prediction is explored. The approach includes first a forecast of global sea surface temperatures (SSTs) using a coupled general circulation model, followed by an atmospheric forecast using an atmospheric general circulation model (AGCM). For this exploration, ensembles of decade-long integrations of the AGCM driven by observed SSTs and ensembles of integrations of select cases driven by forecast SSTs have been conducted. The ability of the model in these sets of runs to reproduce observed atmospheric conditions has been evaluated with a multiparameter performance analysis.Results have identified performance and skill levels in the specified SST runs, for winters and springs over the Pacific/North America region, that are sufficient to impact operational seasonal predictions in years with major El Niño-Southern Oscillation (ENSO) episodes. Further, these levels were substantially reproduced in the forecast SST runs for 1-month leads and in many instances for up to one-season leads. In fact, overall the 0- and 1-month-lead forecasts of seasonal temperature over the United States for three falls and winters with major ENSO episodes were substantially better than corresponding official forecasts. Thus, there is considerable reason to develop a dynamical component for the official seasonal forecast process.

Muscular damage and intravascular haemolysis during an 18 hour subterranean exploration in a cave of 700 m depth

PubMed Central

Stenner, E; Gianoli, E; Biasioli, B; Piccinini, C; Delbello, G; Bussani, A

2006-01-01

Objective To verify presence and severity of muscular and/or intravascular damage during a subterranean exploration of long duration. Methods We measured serum levels of creatine kinase (CK) and lactate dehydrogenase (LDH) as markers of muscular damage. We also measured haptoglobin as a marker of intravascular haemolysis, and platelets and leucocytes as markers of inflammation. Results We found in all the participants an increase in CK, LDH, and platelets and leucocytes (mainly due to neutrophilia and monocytosis), and a decrease in the level of haptoglobin and circulating lymphocytes. Conclusions The observed data suggest that continuous effort during long alpine subterranean explorations, environmental conditions, sleep deprivation, multiple impacts on rocks, and compression caused by bindings of the caving harness cause muscle damage, intravascular haemolysis, inflammation response, and immunological changes. PMID:16505080

The Ocean-Atmosphere Hydrothermohaline Conveyor Belt

NASA Astrophysics Data System (ADS)

Döös, Kristofer; Kjellsson, Joakim; Zika, Jan; Laliberté, Frédéric; Brodeau, Laurent

2015-04-01

The ocean thermohaline circulation is linked to the hydrothermal circulation of the atmosphere. The ocean thermohaline circulation is expressed in potential temperature-salinity space and comprises a tropical upper-ocean circulation, a global conveyor belt cell and an Antarctic Bottom Water cell. The atmospheric hydrothermal circulation in a potential temperature-specific humidity space unifies the tropical Hadley and Walker cells as well as the midlatitude eddies into a single, global circulation. Superimposed, these thermohaline and hydrothermal stream functions reveal the possibility of a close connection between some parts of the water and air mass conversions. The exchange of heat and fresh water through the sea surface (precipiation-evaporation) and incoming solar radiation act to make near-surface air warm and moist while making surface water warmer and saltier as both air and water travel towards the Equator. In the tropics, air masses can undergo moist convection releasing latent heat by forming precipitation, thus acting to make warm surface water fresher. We propose that the Clausius-Clapeyron relationship for moist near-surface air acts like a lower bound for the atmospheric hydrothermal cell and an upper bound for the ocean thermohaline Conveyor-Belt cell. The analysis is made by combining and merging the overturning circulation of the ocean and atmosphere by relating the salinity of the ocean to the humidity of the atmosphere, where we set the heat and freshwater transports equal in the two stream functions By using simulations integrated with our Climate-Earth system model EC-Earth, we intend to produce the "hydrothermohaline" stream function of the coupled ocean-atmosphere overturning circulation in one single picture. We explore how the oceanic thermohaline Conveyor Belt can be linked to the global atmospheric hydrothermal circulation and if the water and air mass conversions in humidity-temperature-salinity space can be related and linked to each other along a "line" corresponding to the Clausius-Clapeyron relationship. A geographical description of how and where this occurs together with this new hydrothermohaline stream function will be searched for. The net heat and freshwater transport of the ocean and atmosphere can aslo be calculated from the thermohaline and hydrothermal stream functions. The heat transport across isohumes in the atmosphere and isohalines in the ocean as well as the freshwater transport across isotherms in both the atmosphere and ocean are computed. The maximum heat transport is about 16 PW in the atmosphere, while that of the ocean is just about 1 PW. The freshwater transport across isotherms in the atmosphere and ocean are shown to be tightly connected with a net maximum freshwater transport of 4 SV in the atmosphere and 2 Sv in the ocean.

Superrotation on Venus, on Titan, and Elsewhere

NASA Astrophysics Data System (ADS)

Read, Peter L.; Lebonnois, Sebastien

2018-05-01

The superrotation of the atmospheres of Venus and Titan has puzzled dynamicists for many years and seems to put these planets in a very different dynamical regime from most other planets. In this review, we consider how to define superrotation objectively and explore the constraints that determine its occurrence. Atmospheric superrotation also occurs elsewhere in the Solar System and beyond, and we compare Venus and Titan with Earth and other planets for which wind estimates are available. The extreme superrotation on Venus and Titan poses some difficult challenges for numerical models of atmospheric circulation, much more difficult than for more rapidly rotating planets such as Earth or Mars. We consider mechanisms for generating and maintaining a superrotating state, all of which involve a global meridional overturning circulation. The role of nonaxisymmetric eddies is crucial, however, but the detailed mechanisms may differ between Venus, Titan, and other planets.

Species interactions in occurrence data for a community of tick-transmitted pathogens

PubMed Central

Estrada-Peña, Agustín; de la Fuente, José

2016-01-01

Interactions between tick species, their realized range of hosts, the pathogens they carry and transmit, and the geographic distribution of species in the Western Palearctic were determined based on evidence published between 1970–2014. These relationships were linked to remotely sensed features of temperature and vegetation and used to extract the network of interactions among the organisms. The resulting datasets focused on niche overlap among ticks and hosts, species interactions, and the fraction of the environmental niche in which tick-borne pathogens may circulate as a result of interactions and overlapping environmental traits. The resulting datasets provide a valuable resource for researchers interested in tick-borne pathogens, as they conciliate the abiotic and biotic sides of their niche, allowing exploration of the importance of each host species acting as a vertebrate reservoir in the circulation of tick-transmitted pathogens in the environmental niche. PMID:27479213

Long term cardiovascular consequences of chronic lung disease of prematurity.

PubMed

Poon, Chuen Yeow; Edwards, Martin Oliver; Kotecha, Sailesh

2013-12-01

Pulmonary arterial (PA) hypertension in preterm infant is an important consequence of chronic lung disease of prematurity (CLD) arising mainly due to impaired alveolar development and dysregulated angiogenesis of the pulmonary circulation. Although PA pressure and resistance in these children normalise by school age, their pulmonary vasculature remains hyper-reactive to hypoxia until early childhood. Furthermore, there is evidence that systemic blood pressure in preterm born children with or without CLD is mildly increased at school age and in young adulthood when compared to term-born children. Arterial stiffness may be increased in CLD survivors due to increased smooth muscle tone of the pre-resistance and resistance vessels rather than the loss of elasticity in the large arteries. This review explores the long term effects of CLD on the pulmonary and systemic circulations along with their clinical correlates and therapeutic approaches. Copyright © 2012 Elsevier Ltd. All rights reserved.

Microfluidic strategies for understanding the mechanics of cells and cell-mimetic systems

PubMed Central

Dahl, Joanna B.; Lin, Jung-Ming G.; Muller, Susan J.; Kumar, Sanjay

2016-01-01

Microfluidic systems are attracting increasing interest for the high-throughput measurement of cellular biophysical properties and for the creation of engineered cellular microenvironments. Here we review recent applications of microfluidic technologies to the mechanics of living cells and synthetic cell-mimetic systems. We begin by discussing the use of microfluidic devices to dissect the mechanics of cellular mimics such as capsules and vesicles. We then explore applications to circulating cells, including erythrocytes and other normal blood cells, and rare populations with potential disease diagnostic value, such as circulating tumor cells. We conclude by discussing how microfluidic devices have been used to investigate the mechanics, chemotaxis, and invasive migration of adherent cells. In these ways, microfluidic technologies represent an increasingly important toolbox for investigating cellular mechanics and motility at high throughput and in a format that lends itself to clinical translation. PMID:26134738

Integrating ergonomics into engineering design: the role of objects.

PubMed

Hall-Andersen, Lene Bjerg; Broberg, Ole

2014-05-01

The objective of this study was to explore the role of objects in integrating ergonomic knowledge in engineering design processes. An engineering design case was analyzed using the theoretical concepts of boundary objects and intermediary objects: Boundary objects facilitate collaboration between different knowledge domains, while the aim of an intermediary object is to circulate knowledge and thus produce a distant effect. Adjustable layout drawings served as boundary objects and had a positive impact on the dialog between an ergonomist and designers. An ergonomic guideline document was identified as an intermediary object. However, when the ergonomic guidelines were circulated in the design process, only some of the guidelines were transferred to the design of the sterile processing plant. Based on these findings, recommendations for working with objects in design processes are included. Copyright © 2013 Elsevier Ltd and The Ergonomics Society. All rights reserved.

Integrated exploration for low-temperature geothermal resources in the Honey Lake Basin, California

USGS Publications Warehouse

Schimschal, U.

1991-01-01

An integrated exploration study is presented to locate low-temperature geothermal reservoirs in the Honey Lake area of northern California. Regional studies to locate the geothermal resources included gravity, infra-red, water-temperature, and water-quality analyses. Five anomalies were mapped from resistivity surveys. Additional study of three anomalies by temperature-gradient and seismic methods was undertaken to define structure and potential of the geothermal resource. The gravity data show a graben structure in the area. Seismic reflection data indicate faults associated with surface-resistivity and temperature-gradient data. The data support the interpretation that the shallow reservoirs are replenished along the fault zones by deeply circulating heated meteoric waters. -Author

Aerosol- and greenhouse gas-induced changes in summer rainfall and circulation in the Australasian region: a study using single-forcing climate simulations

NASA Astrophysics Data System (ADS)

Rotstayn, L. D.; Jeffrey, S. J.; Collier, M. A.; Dravitzki, S. M.; Hirst, A. C.; Syktus, J. I.; Wong, K. K.

2012-07-01

We use a coupled atmosphere-ocean global climate model (CSIRO-Mk3.6) to investigate the drivers of trends in summer rainfall and circulation in the vicinity of northern Australia. As part of the Coupled Model Intercomparison Project Phase 5 (CMIP5), we perform a 10-member 21st century ensemble driven by Representative Concentration Pathway 4.5 (RCP4.5). To investigate the roles of different forcing agents, we also perform multiple 10-member ensembles of historical climate change, which are analysed for the period 1951-2010. The historical runs include ensembles driven by "all forcings" (HIST), all forcings except anthropogenic aerosols (NO_AA) and forcing only from long-lived greenhouse gases (GHGAS). Anthropogenic aerosol-induced effects in a warming climate are calculated from the difference of HIST minus NO_AA. CSIRO-Mk3.6 simulates a strong summer rainfall decrease over north-western Australia (NWA) in RCP4.5, whereas simulated trends in HIST are weakly positive (but insignificant) during 1951-2010. The weak rainfall trends in HIST are due to compensating effects of different forcing agents: there is a significant decrease in GHGAS, offset by an aerosol-induced increase. Observations show a significant increase of summer rainfall over NWA during the last few decades. The large magnitude of the observed NWA rainfall trend is not captured by 440 unforced 60-yr trends calculated from a 500-yr pre-industrial control run, even though the model's decadal variability appears to be realistic. This suggests that the observed trend includes a forced component, despite the fact that the model does not simulate the magnitude of the observed rainfall increase in response to "all forcings" (HIST). We investigate the mechanism of simulated and observed NWA rainfall changes by exploring changes in circulation over the Indo-Pacific region. The key circulation feature associated with the rainfall increase in reanalyses is a lower-tropospheric cyclonic circulation trend off the coast of NWA, which enhances the monsoonal flow. The model shows an aerosol-induced cyclonic circulation trend off the coast of NWA in HIST minus NO_AA, whereas GHGAS shows an anticyclonic circulation trend. This explains why the aerosol-induced effect is an increase of rainfall over NWA, and the greenhouse gas-induced effect is of opposite sign. Possible explanations for the cyclonic (anticyclonic) circulation trend in HIST minus NO_AA (GHGAS) involve changes in the Walker circulation or the local Hadley circulation. In either case, a plausible atmospheric mechanism is that the circulation anomaly is a Rossby wave response to convective heating anomalies south of the Equator. We also discuss the possible role of air-sea interactions, e.g. an increase (decrease) of sea-surface temperatures off the coast of NWA in HIST minus NO_AA (GHGAS). Further research is needed to better understand the mechanisms and the extent to which these are model-dependent. In summary, our results suggest that anthropogenic aerosols may have "masked" greenhouse gas-induced changes in rainfall over NWA and in circulation over the wider Indo-Pacific region. Due to the opposing effects of greenhouse gases and anthropogenic aerosols, future trends may be very different from trends observed over the last few decades.

Pressure Regulator With Internal Ejector Circulation Pump, Flow and Pressure Measurement Porting, and Fuel Cell System Integration Options

NASA Technical Reports Server (NTRS)

Vasquez, Arturo

2011-01-01

An advanced reactant pressure regulator with an internal ejector reactant circulation pump has been developed to support NASA's future fuel cell power systems needs. These needs include reliable and safe operation in variable-gravity environments, and for exploration activities with both manned and un manned vehicles. This product was developed for use in Proton Exchange Membrane Fuel Cell (PEMFC) power plant reactant circulation systems, but the design could also be applied to other fuel cell system types, (e.g., solid-oxide or alkaline) or for other gas pressure regulation and circulation needs. The regulator design includes porting for measurement of flow and pressure at key points in the system, and also includes several fuel cell system integration options. NASA has recognized ejectors as a viable alternative to mechanical pumps for use in spacecraft fuel cell power systems. The ejector motive force is provided by a variable, high-pressure supply gas that travels through the ejector s jet nozzle, whereby the pressure energy of the fluid stream is converted to kinetic energy in the gas jet. The ejector can produce circulation-to-consumption-flow ratios that are relatively high (2-3 times), and this phenomenon can potentially (with proper consideration of the remainder of the fuel cell system s design) be used to provide completely for reactant pre-humidification and product water removal in a fuel cell system. Specifically, a custom pressure regulator has been developed that includes: (1) an ejector reactant circulation pump (with interchangeable jet nozzles and mixer sections, gas-tight sliding and static seals in required locations, and internal fluid porting for pressure-sensing at the regulator's control elements) and (2) internal fluid porting to allow for flow rate and system pressure measurements. The fluid porting also allows for inclusion of purge, relief, and vacuum-breaker check valves on the regulator assembly. In addition, this regulator could also be used with NASA's advanced nonflow-through fuel cell power systems by simply incorporating a jet nozzle with an appropriate nozzle diameter.

The next GUM and its proposals: a comparison study

NASA Astrophysics Data System (ADS)

Damasceno, J. C.; Couto, P. R. G.

2018-03-01

The Guide to the Expression of Uncertainty in Measurement (GUM) is currently under revision. New proposals for its implementation were circulated in the form of a draft document. Two of the main changes are explored in this work using a Brinell hardness model example. Changes in the evaluation of uncertainty for repeated indications and in the construction of coverage intervals are compared with the classic GUM and with Monte Carlo simulation method.

Impaired circulating CD4+ LAP+ regulatory T cells in patients with acute coronary syndrome and its mechanistic study.

PubMed

Zhu, Zheng-Feng; Meng, Kai; Zhong, Yu-Cheng; Qi, Liang; Mao, Xiao-Bo; Yu, Kun-Wu; Zhang, Wei; Zhu, Peng-Fei; Ren, Ze-Peng; Wu, Bang-Wei; Ji, Qin-Wei; Wang, Xiang; Zeng, Qiu-Tang

2014-01-01

CD4(+) latency-associated peptide (LAP)(+) regulatory T cells (Tregs) are a newly discovered T cell subset in humans and the role of these cells in patients with acute coronary syndrome (ACS) has not been explored. We designed to investigate whether circulating frequency and function of CD4(+)LAP(+) Tregs are defective in ACS. One hundred eleven ACS patients (acute myocardial infarction and unstable angina) and 117 control patients were enrolled in the study. The control patients consisted of chronic stable angina (CSA) and chest pain syndrome (CPS). The frequencies of circulating CD4(+)LAP(+) Tregs and the expression of the transmembrane protein glycoprotein-A repetitions predominant (GARP) on CD4(+) T cells were determined by flow cytometry. The function of CD4(+)LAP(+) Tregs was detected using thymidine uptake. Serum interleukin-10 (IL-10) and transforming growth factor-β protein (TGF-β) levels were detected using ELISA and expression of GARP mRNA in peripheral blood mononuclear cells (PBMCs) was measured by real time-polymerase chain reaction. We found ACS patients had a significantly lower frequency of circulating CD4(+)LAP(+) Tregs, and the function of these cells was reduced compared to controls. The expression of GARP in CD4(+) T cells and the serum levels of TGF-β in ACS patients were lower than those of control patients. The serum levels of IL-10 were similar between the two cohorts. A novel regulatory T cell subset, defined as CD4(+)LAP(+) T cells is defective in ACS patients.

Association of oxidative DNA damage, protein oxidation and antioxidant function with oxidative stress induced cellular injury in pre-eclamptic/eclamptic mothers during fetal circulation.

PubMed

Negi, Reena; Pande, Deepti; Karki, Kanchan; Kumar, Ashok; Khanna, Ranjana S; Khanna, Hari D

2014-02-05

Pre-eclampsia is a devastating multi system syndrome and a major cause of maternal, fetal, neonatal morbidity and mortality. Pre-eclampsia is associated with oxidative stress in the maternal circulation. To have an insight on the effect of pre-eclampsia/eclampsia on the neonates, the study was made to explore the oxidative status by quantification of byproducts generated during protein oxidation and oxidative DNA damage and deficient antioxidant activity in umbilical cord blood of pre-eclamptic/eclamptic mothers during fetal circulation. Umbilical cord blood during delivery from neonates born to 19 pre-eclamptic mothers, 14 eclamptic mothers and 18 normotensive mothers (uncomplicated pregnancy) as control cases was collected. 8-OHdG (8-hydroxy-2-deoxyguanosine), protein carbonyl, nitrite, catalase, non-enzymatic antioxidants (vitamin A, E, C), total antioxidant status and iron status were determined. Significant elevation in the levels of 8-OHdG, protein carbonyl, nitrite and iron along with decreased levels of catalase, vitamin A, E, C, total antioxidant status were observed in the umbilical cord blood of pre-eclamptic and eclamptic pregnancies. These parameters might be influential variables for the risk of free radical damage in infants born to pre-eclamptic/eclamptic pregnancies. Increased oxidative stress causes oxidation of DNA and protein which alters antioxidant function. Excess iron level and decreased unsaturated iron binding capacity may be the important factor associated with oxidative stress and contribute in the pathogenesis of pre-eclampsia/eclampsia which is reflected in fetal circulation. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

Distensibility and pressure-flow relationship of the pulmonary circulation. II. Multibranched model.

PubMed

Bshouty, Z; Younes, M

1990-04-01

The contribution of distensibility and recruitment to the distinctive behavior of the pulmonary circulation is not known. To examine this question we developed a multibranched model in which an arterial vascular bed bifurcates sequentially up to 8 parallel channels that converge and reunite at the venous side to end in the left atrium. Eight resistors representing the capillary bed separate the arterial and venous beds. The elastic behavior of capillaries and extra-alveolar vessels was modeled after Fung and Sobin (Circ. Res. 30: 451-490, 1972) and Smith and Mitzner (J. Appl. Physiol. 48: 450-467, 1980), respectively. Forces acting on each component are modified and calculated individually, thus enabling the user to explore the effects of parallel and longitudinal heterogeneities in applied forces (e.g., gravity, vasomotor tone). Model predictions indicate that the contribution of distensibility to nonlinearities in the pressure-flow (P-F) and atrial-pulmonary arterial pressure (Pla-Ppa) relationships is substantial, whereas gravity-related recruitment contributes very little to these relationships. In addition, Pla-Ppa relationships, obtained at a constant flow, have no discriminating ability in identifying the presence or absence of a waterfall along the circulation. The P-F relationship is routinely shifted in a parallel fashion, within the physiological flow range, whenever extra forces (e.g., lung volume, tone) are applied uniformly at one or more branching levels, regardless of whether a waterfall is created. For a given applied force, the magnitude of parallel shift varies with proportion of the circulation subjected to the added force and with Pla.

Aspects of oceanic forcing of drought over Southwest Asia and the United States

NASA Astrophysics Data System (ADS)

Hoell, Andrew

An exceptionally severe drought affected much of the Northern Hemisphere mid-latitudes during 1998 -- 2002, with maxima over Southwest Asia and the United States. Previous research has suggested that the oceans played an important role in the hemispheric drought, with oceanic links to tropical Indo-west Pacific Ocean convection highlighted as important for Southwest Asia, and several additional ocean regions suggested as important for the United States. Here, the regional and hemispheric circulation response to tropical Indo-west Pacific Ocean convection is examined for both Southwest Asia and the United States, and the relative importance of individual sea surface temperature areas are explored for United States precipitation. For Southwest Asia, the regional thermodynamic forcing of precipitation and the Northern Hemisphere circulation are related to the leading pattern of Indian Ocean precipitation and its intraseasonal and interannual contributions. Both intraseasonal and interannual timescales are associated with baroclinic Gill-Matsuno-like circulation responses extending over southern Asia, but the interannual component also has a strong equivalent-barotropic circulation. A stationary barotropic Rossby wave extending over North America is associated with interannual tropical Indo-west Pacific Ocean convection and is supported by barotropic ray tracing. For United States regions, historical SST and precipitation links are identified for 1948 -- 1997, and the importance of these links are assessed during the 1998 -- 2002 drought using a linear regression model. The reconstructed precipitation has good correspondence for the Southwest and Southeast United States, but is not able to reproduce precipitation variability over the Northwest and Central United States, especially Texas.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hazra, Gopal; Karak, Bidya Binay; Choudhuri, Arnab Rai, E-mail: ghazra@physics.iisc.ernet.in

The solar activity cycle is successfully modeled by the flux transport dynamo, in which the meridional circulation of the Sun plays an important role. Most of the kinematic dynamo simulations assume a one-cell structure of the meridional circulation within the convection zone, with the equatorward return flow at its bottom. In view of the recent claims that the return flow occurs at a much shallower depth, we explore whether a meridional circulation with such a shallow return flow can still retain the attractive features of the flux transport dynamo (such as a proper butterfly diagram, the proper phase relation betweenmore » the toroidal and poloidal fields). We consider additional cells of the meridional circulation below the shallow return flow—both the case of multiple cells radially stacked above one another and the case of more complicated cell patterns. As long as there is an equatorward flow in low latitudes at the bottom of the convection zone, we find that the solar behavior is approximately reproduced. However, if there is either no flow or a poleward flow at the bottom of the convection zone, then we cannot reproduce solar behavior. On making the turbulent diffusivity low, we still find periodic behavior, although the period of the cycle becomes unrealistically large. In addition, with a low diffusivity, we do not get the observed correlation between the polar field at the sunspot minimum and the strength of the next cycle, which is reproduced when diffusivity is high. On introducing radially downward pumping, we get a more reasonable period and more solar-like behavior even with low diffusivity.« less

On the Planning and Design of Hospital Circulation Zones.

PubMed

Jiang, Shan; Verderber, Stephen

2017-01-01

This present literature review explores current issues and research inconsistencies regarding the design of hospital circulation zones and the associated health-related outcomes. Large general hospitals are immense, highly sophisticated institutions. Empirical studies have indicated excessively institutional environments in large medical centers are a cause of negative effects to occupants, including stress, anxiety, wayfinding difficulties and spatial disorientation, lack of cognitional control, and stress associated with inadequate access to nature. The rise of patient-centered and evidence-based movements in healthcare planning and design has resulted in a general rise in the quality of hospital physical environments. However, as a core component of any healthcare delivery system, hospital circulation zones have tended to remain neglected within the comparatively broad palette of research conducted and reported to date. A systematic literature review was conducted based upon combinations of key words developed vis-à-vis a literature search in 11 major databases in the realm of the health sciences and the planning and design of built environments for healthcare. Eleven peer-reviewed articles were included in the analysis. Six research themes were identified according to associated health-related outcomes, including wayfinding difficulties and spatial disorientation, communication and socialization patterns, measures and control of excessive noise, patient fall incidents, and occupants' stress and satisfaction levels. Several knowledge gaps as well as commonalities in the pertinent research literature were identified. Perhaps the overriding finding is that occupants' meaningful exposure to views of nature from within hospital circulation zones can potentially enhance wayfinding and spatial navigation. Future research priories on this subject are discussed.

Maternal Phthalate and Personal Care Products Exposure Alters Extracellular Placental miRNA Profile in Twin Pregnancies.

PubMed

Zhong, Jia; Baccarelli, Andrea A; Mansur, Abdallah; Adir, Michal; Nahum, Ravit; Hauser, Russ; Bollati, Valentina; Racowsky, Catherine; Machtinger, Ronit

2018-01-01

Prenatal exposure to endocrine-disrupting chemicals (EDCs) exerts both short- and long-term adverse effects on the developing fetus. However, the mechanisms underlying these effects have yet to be uncovered. Maternal-fetal signaling is mediated in part by signaling molecules (eg, microRNAs [miRNAs]) contained in extracellular vesicles (EVs) that are released by the placenta into the maternal circulation. We investigated whether maternal exposure to the EDCs phthalates and personal care products alters the miRNA profile of placental-derived EVs circulating in maternal blood. Blood and urine samples from pregnant women with uncomplicated term dichorionic, diamniotic twin pregnancies were analyzed as part of a larger study investigating correlations between exposure of phthalate and personal care products and epigenetic alterations in twin pregnancies. We explored correlations between maternal urinary levels of 13 phthalate and 12 personal care products metabolites and the miRNA profile of placental EVs (EV-miRNAs) circulating in maternal blood. The expression of miR-518e was highest among women with high urinary levels of monobenzyl phthalate and methyl paraben. miR-373-3p was the least expressed in women exposed to high levels of methyl paraben, and miR-543 was significantly downregulated in women exposed to high levels of paraben metabolites, dichlorophenol metabolites, and triclosan. In conclusion, this pilot study reveals that prenatal exposure to EDCs is associated with altered profile of circulating placenta-derived EV-miRNAs. Further studies are needed to generalize these results to singleton pregnancies and to assess whether these alterations are associated with pregnancy complications.

Simulation of Asian monsoon seasonal variations with climate model R42L9/LASG

NASA Astrophysics Data System (ADS)

Wang, Zaizhi; Wu, Guoxiong; Wu, Tongwen; Yu, Rucong

2004-12-01

The seasonal variations of the Asian monsoon were explored by applying the atmospheric general circulation model R42L9 that was developed recently at the State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics, Institute of Atmospheric Physics, Chinese Academy of Sciences (LASG/IAP/CAS). The 20-yr (1979 1998) simulation was done using the prescribed 20-yr monthly SST and sea-ice data as required by Atmospheric Model Intercomparison Project (AMIP) II in the model. The monthly precipitation and monsoon circulations were analyzed and compared with the observations to validate the model’s performance in simulating the climatological mean and seasonal variations of the Asian monsoon. The results show that the model can capture the main features of the spatial distribution and the temporal evolution of precipitation in the Indian and East Asian monsoon areas. The model also reproduced the basic patterns of monsoon circulation. However, some biases exist in this model. The simulation of the heating over the Tibetan Plateau in summer was too strong. The overestimated heating caused a stronger East Asian monsoon and a weaker Indian monsoon than the observations. In the circulation fields, the South Asia high was stronger and located over the Tibetan Plateau. The western Pacific subtropical high was extended westward, which is in accordance with the observational results when the heating over the Tibetan Plateau is stronger. Consequently, the simulated rainfall around this area and in northwest China was heavier than in observations, but in the Indian monsoon area and west Pacific the rainfall was somewhat deficient.

Micro RNAs from DNA Viruses are Found Widely in Plasma in a Large Observational Human Population.

PubMed

Koupenova, Milka; Mick, Eric; Corkrey, Heather A; Huan, Tianxiao; Clancy, Lauren; Shah, Ravi; Benjamin, Emelia J; Levy, Daniel; Kurt-Jones, Evelyn A; Tanriverdi, Kahraman; Freedman, Jane E

2018-04-23

Viral infections associate with disease risk and select families of viruses encode miRNAs that control an efficient viral cycle. The association of viral miRNA expression with disease in a large human population has not been previously explored. We sequenced plasma RNA from 40 participants of the Framingham Heart Study (FHS, Offspring Cohort, Visit 8) and identified 3 viral miRNAs from 3 different human Herpesviridae. These miRNAs were mostly related to viral latency and have not been previously detected in human plasma. Viral miRNA expression was then screened in the plasma of 2763 participants of the remaining cohort utilizing high-throughput RT-qPCR. All 3 viral miRNAs associated with combinations of inflammatory or prothrombotic circulating biomarkers (sTNFRII, IL-6, sICAM1, OPG, P-selectin) but did not associate with hypertension, coronary heart disease or cancer. Using a large observational population, we demonstrate that the presence of select viral miRNAs in the human circulation associate with inflammatory biomarkers and possibly immune response, but fail to associate with overt disease. This study greatly extends smaller singular observations of viral miRNAs in the human circulation and suggests that select viral miRNAs, such as those for latency, may not impact disease manifestation.

Regional drought shifts (1710-2010) in East Central Asia and linkages with atmospheric circulation recorded in tree-ring δ18O

NASA Astrophysics Data System (ADS)

Xu, Guobao; Liu, Xiaohong; Trouet, Valerie; Treydte, Kerstin; Wu, Guoju; Chen, Tuo; Sun, Weizhen; An, Wenling; Wang, Wenzhi; Zeng, Xiaomin; Qin, Dahe

2018-04-01

Drought occurrence and duration in central Asia are of important socioeconomic, ecological, and geophysical significance and have received increasing research attention in recent years. Understanding long-term drought trends and their driving forces require reliable records of past drought variability with broad spatial representativeness. Here, we compiled four tree-ring δ18O records from eastern central Asia (ECA) and composited them into a drought-sensitive proxy to explore regional ECA moisture variations over the past 301 years (1710-2010 CE). A robust regional standardized precipitation-evapotranspiration index (SPEI) reconstruction was established based on the tree-ring cellulose δ18O fractionation mechanism and statistically significant proxy-climate relationships. We identified prominent droughts in 1710-1770, 1810-1830, and the beginning of the twenty-first century, and a regime shift to a persistently wet period from the 1880s to 2000. Our reconstruction reveals the impact of drought and pluvial patterns on the decline of Zhungar Empire, and on historical agricultural and socio-economical activities, including increased migration into ECA during the 1770-1800 pluvial. Our findings also suggest that wet conditions in the twentieth century in ECA were related to a strengthening of the westerly circulation and thus shed light on large-scale atmospheric circulation dynamics in central Asia.

Prognostic residual mean flow in an ocean general circulation model and its relation to prognostic Eulerian mean flow

DOE PAGES

Saenz, Juan A.; Chen, Qingshan; Ringler, Todd

2015-05-19

Recent work has shown that taking the thickness-weighted average (TWA) of the Boussinesq equations in buoyancy coordinates results in exact equations governing the prognostic residual mean flow where eddy–mean flow interactions appear in the horizontal momentum equations as the divergence of the Eliassen–Palm flux tensor (EPFT). It has been proposed that, given the mathematical tractability of the TWA equations, the physical interpretation of the EPFT, and its relation to potential vorticity fluxes, the TWA is an appropriate framework for modeling ocean circulation with parameterized eddies. The authors test the feasibility of this proposition and investigate the connections between the TWAmore » framework and the conventional framework used in models, where Eulerian mean flow prognostic variables are solved for. Using the TWA framework as a starting point, this study explores the well-known connections between vertical transfer of horizontal momentum by eddy form drag and eddy overturning by the bolus velocity, used by Greatbatch and Lamb and Gent and McWilliams to parameterize eddies. After implementing the TWA framework in an ocean general circulation model, we verify our analysis by comparing the flows in an idealized Southern Ocean configuration simulated using the TWA and conventional frameworks with the same mesoscale eddy parameterization.« less

HIV-1/HAART-Related Lipodystrophy Syndrome (HALS) Is Associated with Decreased Circulating sTWEAK Levels.

PubMed

López-Dupla, Miguel; Maymó-Masip, Elsa; Martínez, Esteban; Domingo, Pere; Leal, Manuel; Peraire, Joaquim; Viladés, Consuelo; Veloso, Sergi; Arnedo, Mireia; Ferrando-Martínez, Sara; Beltrán-Debón, Raúl; Alba, Verónica; Gatell, Josep Ma; Vendrell, Joan; Vidal, Francesc; Chacón, Matilde R

2015-01-01

Obesity and HIV-1/HAART-associated lipodystrophy syndrome (HALS) share clinical, pathological and mechanistic features. Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) is a multifunctional cytokine that plays an important role in obesity and related diseases. We sought to explore the relationship between HALS and circulating levels of soluble (s) TWEAK and its scavenger receptor sCD163. This was a cross-sectional multicenter study of 120 HIV-1-infected patients treated with a stable HAART regimen; 56 with overt HALS and 64 without HALS. Epidemiological and clinical variables were determined. Serum levels of sTWEAK and sCD163 levels were measured by ELISA. Results were analyzed with Student's t-test, Mann-Whitney U and χ2 test. Pearson and Spearman correlation were used to estimate the strength of association between variables. Circulating sTWEAK was significantly decreased in HALS patients compared with non-HALS patients (2.81±0.2 vs. 2.94±0.28 pg/mL, p = 0.018). No changes were observed in sCD163 levels in the studied cohorts. On multivariate analysis, a lower log sTWEAK concentration was independently associated with the presence of HALS (OR 0.027, 95% CI 0.001-0.521, p = 0.027). HALS is associated with decreased sTWEAK levels.

Intraseasonal and Interannual Variability of Mars Present Climate

NASA Astrophysics Data System (ADS)

Hollingsworth, Jeffery L.; Bridger, Alison F. C.; Haberle, Robert M.

1996-01-01

This is a Final Report for a Joint Research Interchange (JRI) between NASA Ames Research Center and San Jose State University, Department of Meteorology. The focus of this JRI has been to investigate the nature of intraseasonal and interannual variability of Mars'present climate. We have applied a three-dimensional climate model based on the full hydrostatic primitive equations to determine the spatial, but primarily, the temporal structures of the planet's large-scale circulation as it evolves during a given seasonal advance, and, over multi-annual cycles. The particular climate model applies simplified physical parameterizations and is computationally efficient. It could thus easily be integrated in a perpetual season or advancing season configuration, as well as over many Mars years. We have assessed both high and low-frequency components of the circulation (i.e., motions having periods of Omicron(2-10 days) or greater than Omicron(10 days), respectively). Results from this investigation have explored the basic issue whether Mars' climate system is naturally 'chaotic' associated with nonlinear interactions of the large-scale circulation-regardless of any allowance for year-to-year variations in external forcing mechanisms. Titles of papers presented at scientific conferences and a manuscript to be submitted to the scientific literature are provided. An overview of a areas for further investigation is also presented.

Ciculating miRNA-21 as a Biomarker Predicts Polycystic Ovary Syndrome (PCOS) in Patients.

PubMed

Jiang, Liyan; Li, Wei; Wu, Minmin; Cao, Sifan

2015-01-01

Polycystic ovary syndrome (PCOS) is characterized by hyperandrogenism, hyperinsulinemia, and infertility. In PCOS, abnormal regulation of relevant genes is required for follicular development. By binding to the 3' untranslated region (3'URT), microRNAs (miRNAs) are widely involved in posttranscriptional gene regulation. However, few studies have been conducted on circulating miRNA expression in PCOS. This study aims to describe altered expression of circulating miR-21 in PCOS. The expression of serum miRNAs of PCOS patients were explored using the TaqMan Low Density Array followed by individual quantitative reverse transcription polymerase chain reaction assays. The protein level of LATS1 was determined using Western blot. To validate whether miR-21 targeted LATS1, the luciferase assay was applied. In comparison with normal subjects, the circulating level of miRNA-21 was significantly enhanced in PCOS patients. In PCOS patients, the expression levels of MST1/2, LATS1/2, TAZ were much lower than the control subjects. Luciferase reporter assay revealed that LATS1 was a downstream target of miR-21. In comparison with normal subjects, serum miR-21 is obviously increased in PCOS patients. Through targeting LATS1, miR-21 could prompt PCOS progression and could act as a novel non-invasive biomarker for diagnosis of PCOS.

Extending the NASA Ames Mars General Circulation Model to Explore Mars’ Middle Atmosphere

NASA Astrophysics Data System (ADS)

Brecht, Amanda; Hollingsworth, J.; Kahre, M.; Schaeffer, J.

2013-10-01

The NASA Ames Mars General Circulation Model (MGCM) upper boundary has been extended to ~120 km altitude (p ~10-5 mbar). The extension of the MGCM upper boundary initiates the ability to understand the connection between the lower and upper atmosphere of Mars through the middle atmosphere 70 - 120 km). Moreover, it provides the opportunity to support future missions (i.e. the 2013 MAVEN mission). A major factor in this extension is the incorporation of the Non-Local Thermodynamic Equilibrium (NLTE) heating (visible) and cooling (infrared). This modification to the radiative transfer forcing (i.e., RT code) has been significantly tested in a 1D vertical column and now has been ported to the full 3D Mars GCM. Initial results clearly show the effects of NLTE in the upper middle atmosphere. Diagnostic of seasonal mean fields and large-scale wave activity will be shown with insight into circulation patterns in the middle atmosphere. Furthermore, sensitivity tests with the resolution of the pressure and temperature grids, in which the k-coefficients are calculated upon, have been performed in the 1D RT code. Our progress on this research will be presented. Brecht is supported by NASA’s Postdoctoral Program at the Ames Research Center, administered by Oak Ridge Associated Universities through a contract with NASA.

Regional circulation around New Caledonia from two decades of observations

NASA Astrophysics Data System (ADS)

Cravatte, Sophie; Kestenare, Elodie; Eldin, Gérard; Ganachaud, Alexandre; Lefèvre, Jérôme; Marin, Frédéric; Menkes, Christophe; Aucan, Jérôme

2015-08-01

The regional and near-coastal circulation around New Caledonia is investigated using a compilation of more than 20 years of observations. Velocity profiles acquired by Shipboard Acoustic Doppler Current Profiler (SADCP) during 109 research cruises and ship transits since 1991 are analyzed and compared with absolute geostrophic currents inferred from hydrographic profiles and Argo floats drifts. In addition, altimetric surface currents are used to explore the variability of the circulation at various timescales. By making the best use of the strength of these various observations, this study provides an unprecedented detailed picture of the mean circulation around New Caledonia and of its variability in the upper layers. New Caledonia, together with the Vanuatu Archipelago and the Fiji Islands, acts as a 750-km long obstacle to the westward South Equatorial Current (SEC) entering the Coral Sea. On average, the SEC bifurcates against New Caledonia's east coast into a northwestward boundary current, the East Caledonian Current, beginning east of the Loyalty Islands and extending to at least 1000 m depth, and into a weak southeastward current. The latter, the Vauban Current, flows into the Loyalty channel against the mean trade winds where it extends to at least 500 m depth. It is highly variable at intraseasonal timescales; it often reverses and its variability is mainly driven by incoming mesoscale eddies east and south of New Caledonia. West of the Island, the southeastward Alis Current of New Caledonia (ACNC) flows along the reef slope in the 0-150 m layer. It overlays a weaker northwestward current, creating an unusual coastal circulation reminiscent of the current system along the Australian west coast. The ACNC is a persistent feature of the observations, even if its transport is also strongly modulated by the presence of offshore eddies. This study highlights the fact, if needed, that a snapshot view of the currents provided by a single transect can be strongly impacted by mesoscale eddies, and should be put into context, e.g. by using simultaneous altimetric data.

Agro-Environmental Determinants of Avian Influenza Circulation: A Multisite Study in Thailand, Vietnam and Madagascar

PubMed Central

Paul, Mathilde C.; Gilbert, Marius; Desvaux, Stéphanie; Rasamoelina Andriamanivo, Harena; Peyre, Marisa; Khong, Nguyen Viet; Thanapongtharm, Weerapong; Chevalier, Véronique

2014-01-01

Outbreaks of highly pathogenic avian influenza have occurred and have been studied in a variety of ecological systems. However, differences in the spatial resolution, geographical extent, units of analysis and risk factors examined in these studies prevent their quantitative comparison. This study aimed to develop a high-resolution, comparative study of a common set of agro-environmental determinants of avian influenza viruses (AIV) in domestic poultry in four different environments: (1) lower-Northern Thailand, where H5N1 circulated in 2004–2005, (2) the Red River Delta in Vietnam, where H5N1 is circulating widely, (3) the Vietnam highlands, where sporadic H5N1 outbreaks have occurred, and (4) the Lake Alaotra region in Madagascar, which features remarkable similarities with Asian agro-ecosystems and where low pathogenic avian influenza viruses have been found. We analyzed H5N1 outbreak data in Thailand in parallel with serological data collected on the H5 subtype in Vietnam and on low pathogenic AIV in Madagascar. Several agro-environmental covariates were examined: poultry densities, landscape dominated by rice cultivation, proximity to a water body or major road, and human population density. Relationships between covariates and AIV circulation were explored using spatial generalized linear models. We found that AIV prevalence was negatively associated with distance to the closest water body in the Red River Delta, Vietnam highlands and Madagascar. We also found a positive association between AIV and duck density in the Vietnam highlands and Thailand, and with rice landscapes in Thailand and Madagascar. Our findings confirm the important role of wetlands-rice-ducks ecosystems in the epidemiology of AI in diverse settings. Variables influencing circulation of the H5 subtype in Southeast Asia played a similar role for low pathogenic AIV in Madagascar, indicating that this area may be at risk if a highly virulent strain is introduced. PMID:25029441

Agro-environmental determinants of avian influenza circulation: a multisite study in Thailand, Vietnam and Madagascar.

PubMed

Paul, Mathilde C; Gilbert, Marius; Desvaux, Stéphanie; Andriamanivo, Harena Rasamoelina; Peyre, Marisa; Khong, Nguyen Viet; Thanapongtharm, Weerapong; Chevalier, Véronique

2014-01-01

Outbreaks of highly pathogenic avian influenza have occurred and have been studied in a variety of ecological systems. However, differences in the spatial resolution, geographical extent, units of analysis and risk factors examined in these studies prevent their quantitative comparison. This study aimed to develop a high-resolution, comparative study of a common set of agro-environmental determinants of avian influenza viruses (AIV) in domestic poultry in four different environments: (1) lower-Northern Thailand, where H5N1 circulated in 2004-2005, (2) the Red River Delta in Vietnam, where H5N1 is circulating widely, (3) the Vietnam highlands, where sporadic H5N1 outbreaks have occurred, and (4) the Lake Alaotra region in Madagascar, which features remarkable similarities with Asian agro-ecosystems and where low pathogenic avian influenza viruses have been found. We analyzed H5N1 outbreak data in Thailand in parallel with serological data collected on the H5 subtype in Vietnam and on low pathogenic AIV in Madagascar. Several agro-environmental covariates were examined: poultry densities, landscape dominated by rice cultivation, proximity to a water body or major road, and human population density. Relationships between covariates and AIV circulation were explored using spatial generalized linear models. We found that AIV prevalence was negatively associated with distance to the closest water body in the Red River Delta, Vietnam highlands and Madagascar. We also found a positive association between AIV and duck density in the Vietnam highlands and Thailand, and with rice landscapes in Thailand and Madagascar. Our findings confirm the important role of wetlands-rice-ducks ecosystems in the epidemiology of AI in diverse settings. Variables influencing circulation of the H5 subtype in Southeast Asia played a similar role for low pathogenic AIV in Madagascar, indicating that this area may be at risk if a highly virulent strain is introduced.

THE ATMOSPHERIC CIRCULATION OF THE HOT JUPITER WASP-43b: COMPARING THREE-DIMENSIONAL MODELS TO SPECTROPHOTOMETRIC DATA

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kataria, Tiffany; Showman, Adam P.; Fortney, Jonathan J.

The hot Jupiter WASP-43b (2 M{sub J}, 1 R{sub J}, T {sub orb} = 19.5 hr) has now joined the ranks of transiting hot Jupiters HD 189733b and HD 209458b as an exoplanet with a large array of observational constraints. Because WASP-43b receives a similar stellar flux as HD 209458b but has a rotation rate four times faster and a higher gravity, studying WASP-43b probes the effect of rotation rate and gravity on the circulation when stellar irradiation is held approximately constant. Here we present three-dimensional (3D) atmospheric circulation models of WASP-43b, exploring the effects of composition, metallicity, and frictional drag. We find thatmore » the circulation regime of WASP-43b is not unlike other hot Jupiters, with equatorial superrotation that yields an eastward-shifted hotspot and large day-night temperature variations (∼600 K at photospheric pressures). We then compare our model results to Hubble Space Telescope (HST)/WFC3 spectrophotometric phase curve measurements of WASP-43b from 1.12 to 1.65 μm. Our results show the 5× solar model light curve provides a good match to the data, with a peak flux phase offset and planet/star flux ratio that is similar to observations; however, the model nightside appears to be brighter. Nevertheless, our 5× solar model provides an excellent match to the WFC3 dayside emission spectrum. This is a major success, as the result is a natural outcome of the 3D dynamics with no model tuning. These results demonstrate that 3D circulation models can help interpret exoplanet atmospheric observations, even at high resolution, and highlight the potential for future observations with HST, James Webb Space Telescope, and other next-generation telescopes.« less

The impact of acute high-intensity interval exercise on biomarkers of cardiovascular health in type 2 diabetes.

PubMed

Francois, Monique E; Little, Jonathan P

2017-08-01

High-intensity interval training (HIIT) interventions improve cardiovascular health, yet the acute effects on circulating and functional biomarkers of cardiovascular function are unclear in individuals with type 2 diabetes (T2D). To explore this, we conducted two investigations to examine the acute response to HIIT in individuals with T2D. Study 1 measured blood pressure, endothelial-dependent dilation, circulating measures of endothelial activation, and troponin T, 30 min and 2 h after HIIT (7 × 1-min intervals) in T2D (n = 8) and age-matched normoglycemic controls (CTL; n = 8). Study 2 assessed circulating measures of endothelial activation and troponin T, 30 min, and 24 h after HIIT (10 × 1-min intervals) in ten previously trained T2D men. In study 1, markers of endothelial function and activation within the first 2 h after HIIT did not differ from baseline between T2D and CTL participants, except at 30 min after HIIT for glucose, which was reduced more in T2D than CTL (by -0.8 ± 1.2 mmol/L, p = 0.04), and VCAM-1, which was reduced more 30 min after HIIT in CTL compared to T2D (by -187 ± 221 ng/mL, p = 0.05). Study 2 saw no significant difference in any circulating markers of endothelial activation and troponin T, 30 min, and 24 h after HIIT in trained T2D males. Exploratory findings from these two studies suggest that acute HIIT does not substantially alter circulating and functional markers of cardio(vascular) health in individuals with T2D who are unaccustomed (study 1) and accustomed to HIIT (study 2).

Protein Restriction with Amino Acid-Balanced Diets Shrinks Circulating Pool Size of Amino Acid by Decreasing Expression of Specific Transporters in the Small Intestine

PubMed Central

Luo, Min; Zhang, Xin; Sun, Wen Juan; Jiao, Ning; Li, De Fa; Yin, Jing Dong

2016-01-01

Dietary protein restriction is not only beneficial to health and longevity in humans, but also protects against air pollution and minimizes feeding cost in livestock production. However, its impact on amino acid (AA) absorption and metabolism is not quite understood. Therefore, the study aimed to explore the effect of protein restriction on nitrogen balance, circulating AA pool size, and AA absorption using a pig model. In Exp.1, 72 gilts weighting 29.9 ± 1.5 kg were allocated to 1 of the 3 diets containing 14, 16, or 18% CP for a 28-d trial. Growth (n = 24), nitrogen balance (n = 6), and the expression of small intestinal AA and peptide transporters (n = 6) were evaluated. In Exp.2, 12 barrows weighting 22.7 ± 1.3 kg were surgically fitted with catheters in the portal and jejunal veins as well as the carotid artery and assigned to a diet containing 14 or 18% CP. A series of blood samples were collected before and after feeding for determining the pool size of circulating AA and AA absorption in the portal vein, respectively. Protein restriction did not sacrifice body weight gain and protein retention, since nitrogen digestibility was increased as dietary protein content reduced. However, the pool size of circulating AA except for lysine and threonine, and most AA flux through the portal vein were reduced in pigs fed the low protein diet. Meanwhile, the expression of peptide transporter 1 (PepT-1) was stimulated, but the expression of the neutral and cationic AA transporter systems was depressed. These results evidenced that protein restriction with essential AA-balanced diets, decreased AA absorption and reduced circulating AA pool size. Increased expression of small intestinal peptide transporter PepT-1 could not compensate for the depressed expression of jejunal AA transporters for AA absorption. PMID:27611307

Reduced circulating levels of sTWEAK are associated with NAFLD and may affect hepatocyte triglyceride accumulation.

PubMed

Lozano-Bartolomé, J; Llauradó, G; Rodriguez, M M; Fernandez-Real, J M; Garcia-Fontgivell, J F; Puig, J; Maymó-Masip, E; Vendrell, J; Chacón, M R

2016-09-01

Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the metabolic syndrome and is strongly associated with obesity, dyslipidaemia and altered glucose regulation. Previous data demonstrated that low circulating levels of tumour necrosis factor weak inducer of apoptosis (sTWEAK) were associated with obesity, diabetes and insulin resistance, all traits associated with an increased risk of NALFD. Circulating sTWEAK levels are expected to be reduced in the presence of NAFLD. We aimed to explore the relationship between NAFLD and circulating sTWEAK levels in obese patients, and to evaluate the effect of sTWEAK on hepatocyte triglyceride accumulation.Design setting and patients:This is an observational case-control study performed in n=112 severely obese patients evaluated for NAFLD by abdominal ultrasound and n=32 non-obese patients without steatosis. Serum sTWEAK concentrations were measured by ELISA. Multivariable analyses were performed to determine the independent predictors of NAFLD. We analysed TWEAK and Fn14 protein expression in liver biopsies by western blotting and immunohistochemistry. An immortalized primary human hepatocyte cell line (HHL) was used to evaluate the effect of sTWEAK on triglyceride accumulation. We observed a reduction in serum circulating sTWEAK concentrations with the presence of liver steatosis. On multivariable analysis, lower sTWEAK concentrations were independently associated with the presence of NAFLD (odds ratio (OR)=0.023; 95% confidence interval: 0.001-0.579; P<0.022). In human hepatocytes, sTWEAK administration reduced fat accumulation as demonstrated by the reduction in palmitic acid-induced accumulation of triglyceride and the decreased expression of cluster of differentiation 36 (CD36) and perilipin 1 and 2 (PLIN1 and PLIN2) genes. Decreased sTWEAK concentrations are independently associated with the presence of NAFLD. This is concordant with the observation that TWEAK reduces lipid accumulation in human liver cells.

Crustal thickness of Antarctica estimated using data from gravimetric satellites

NASA Astrophysics Data System (ADS)

Llubes, Muriel; Seoane, Lucia; Bruinsma, Sean; Rémy, Frédérique

2018-04-01

Computing a better crustal thickness model is still a necessary improvement in Antarctica. In this remote continent where almost all the bedrock is covered by the ice sheet, seismic investigations do not reach a sufficient spatial resolution for geological and geophysical purposes. Here, we present a global map of Antarctic crustal thickness computed from space gravity observations. The DIR5 gravity field model, built from GOCE and GRACE gravimetric data, is inverted with the Parker-Oldenburg iterative algorithm. The BEDMAP products are used to estimate the gravity effect of the ice and the rocky surface. Our result is compared to crustal thickness calculated from seismological studies and the CRUST1.0 and AN1 models. Although the CRUST1.0 model shows a very good agreement with ours, its spatial resolution is larger than the one we obtain with gravimetric data. Finally, we compute a model in which the crust-mantle density contrast is adjusted to fit the Moho depth from the CRUST1.0 model. In East Antarctica, the resulting density contrast clearly shows higher values than in West Antarctica.

Forcing of the Coupled Ionosphere-Thermosphere (IT) System During Magnetic Storms

NASA Technical Reports Server (NTRS)

Huang, Cheryl; Huang, Yanshi; Su, Yi-Jiun; Sutton, Eric; Hairston, Marc; Coley, W. Robin; Doornbos, Eelco; Zhang, Yongliang

2014-01-01

Poynting flux shows peaks around auroral zone AND inside polar cap. Energy enters IT system at all local times in polar cap. Track-integrated flux at DMSP often peaks at polar latitudes- probably due to increased area of polar cap during storm main phases. center dot lon temperatures at DMSP show large increases in polar region at all local times; cusp and auroral zones do not show distinctively high Ti. center dot I on temperatures in the polar cap are higher than in the auroral zones during quiet times. center dot Neutral densities at GRACE and GOCE show maxima at polar latitudes without clear auroral signatures. Response is fast, minutes from onset to density peaks. center dot GUVI observations of O/N2 ratio during storms show similar response as direct measurements of ion and neutral densities, i.e. high temperatures in polar cap during prestorm quiet period, heating proceeding from polar cap to lower latitudes during storm main phase. center dot Discrepancy between maps of Poynting flux and of ion temperatures/neutral densities suggests that connection between Poynting flux and Joule heating is not simple.

Stratigraphic distribution of veins in the Murray and Stimson formations, Gale crater, Mars: Implications for ancient groundwater circulation

NASA Astrophysics Data System (ADS)

Nachon, M.; Sumner, D. Y.; Borges, S. R.; Stack, K.; Stein, N.; Watkins, J. A.; Banham, S.; Rivera-Hernandez, F.; Wiens, R. C.; l'Haridon, J.; Rapin, W.; Kronyak, R. E.

2017-12-01

Since landing at Gale crater, Mars, in August 2012, the Curiosity rover has driven through more than 300m of stratigraphy. From the first to the most recent sedimentary rocks explored, light-toned veins have been observed cutting the host-rock and were interpreted as diagenetic features emplaced by hydraulic fracturing. Chemical and mineralogical analyses show they consist of Ca-sulfate. Here we report on the veins' distribution within two geological formations explored more recently by the rover: (a) the Murray Formation that consists mainly of fine-grained laminated rocks that have been interpreted as having been deposited in a former lacustrine environment [1], and (b) the Stimson Formation, which lies unconformably above the Murray, and consists of cross bedded sandstones interpreted as being deposited in a aeolian environment [2]. We have performed a systematic observation of the veins within the MastCam images, from the base of the Murray (Sol 750) up to Sol 1515 [3], described their main geometrical characteristics (e.g. orientation to laminae, relative density, branching). Five veins facies were defined based on veins' geometrical properties, abundance, and host-rock grain size. The distribution of veins facies was placed within the broader stratigraphic context. The distribution of veins within the Murray and Stimson Formations shows strong rheological controls. In the Murray, light-toned veins are present from the basal part of the section up to the most recently explored exposures. Several dense vein outcrops are associated with local variations in host-rock type, suggesting rheological control of fluid circulation. In Stimson sandstones, light-toned veins are also present though much rarer, again possibly due to rheological properties. The light-toned veins represent post depositional fluid circulation, occurring after accumulation of the lacustrine Murray rocks; at least some veins formed after Murray's burial, erosion, and the deposition and lithification of the overlying Stimson aeolian rocks. Given the distribution of veins, ground water was likely present during an extended time interval, spanning a duration of at least millions of years. [1]Grotzinger et al., 2015, DOI: 10.1126/science.aac7575 [2]Banham et al., 2017, this meeting [3]Nachon et al., 2017, AbSciCon #3667

The East African monsoon system: Seasonal climatologies and recent variations: Chapter 10

USGS Publications Warehouse

Funk, Christopher C.; Hoell, Andrew; Shukla, Shraddhanand; Husak, Gregory J.; Michaelsen, J.

2016-01-01

This chapter briefly reviews the complex climatological cycle of the East African monsoon system, paying special attention to its connection to the larger Indo-Pacific-Asian monsoon cycle. We examine the seasonal monsoon cycle, and briefly explore recent circulation changes. The spatial footprint of our analysis corresponds with the “Greater Horn of Africa” (GHA) region, extending from Tanzania in the south to Yemen and Sudan in the north. During boreal winter, when northeast trade winds flow across the northwest Indian Ocean and the equatorial moisture transports over the Indian Ocean exhibit strong westerly mean flows over the equatorial Indian Ocean, East African precipitation is limited to a few highland areas. As the Indian monsoon circulation transitions during boreal spring, the trade winds over the northwest Indian Ocean reverse, and East African moisture convergence supports the “long” rains. In boreal summer, the southwesterly Somali Jet intensifies over eastern Africa. Subsidence forms along the westward flank of this jet, shutting down precipitation over eastern portions of East Africa. In boreal fall, the Jet subsides, but easterly moisture transports support rainfall in limited regions of the eastern Horn of Africa. We use regressions with the trend mode of global sea surface temperatures to explore potential changes in the seasonal monsoon circulations. Significant reductions in total precipitable water are indicated in Kenya, Tanzania, Rwanda, Burundi, Uganda, Ethiopia, South Sudan, Sudan, and Yemen, with moisture transports broadly responding in ways that reinforce the climatological moisture transports over the Indian Ocean. Over Kenya, southern Ethiopia and Somalia, regressions with velocity potential indicate increased convergence aloft. Near the surface, this convergence appears to manifest as a surface high pressure system that modifies moisture transports in these countries as well as Uganda, Tanzania, Rwanda, and Burundi. An analysis of rainfall changes indicates significant declines in parts of Tanzania, Rwanda, Burundi, Uganda, Kenya, Somalia, Ethiopia, and Yemen.

Depression in type 1 diabetes was associated with high levels of circulating galectin-3

PubMed Central

Melin, Eva Olga; Dereke, Jonatan; Thunander, Maria; Hillman, Magnus

2018-01-01

Objective Neuroinflammatory responses are implicated in depression. The aim was to explore whether depression in patients with type 1 diabetes (T1D) was associated with high circulating galectin-3, controlling for metabolic variables, s-creatinine, life style factors, medication and cardiovascular complications. Design Cross-sectional. Methods Participants were T1D patients (n = 283, 56% men, age 18–59 years, diabetes duration ≥1 year). Depression was assessed by Hospital Anxiety and Depression Scale-depression subscale. Blood samples, anthropometrics and blood pressure were collected, and supplemented with data from medical records and the Swedish National Diabetes Registry. Galectin-3 ≥2.562 µg/l, corresponding to the 85th percentile, was defined as high galectin-3. Results Median (quartile1, quartile3) galectin-3 (µg/l) was 1.3 (0.8, 2.9) for the 30 depressed patients, and 0.9 (0.5, 1.6) for the 253 non-depressed, P = 0.009. Depression was associated with high galectin-3 in all the 283 patients (adjusted odds ratio (AOR) 3.5), in the 161 men (AOR 3.4), and in the 122 women (AOR 3.9). HbA1c, s-lipids, s-creatinine, blood pressure, obesity, smoking, physical inactivity, cardiovascular complications and drugs (antihypertensive, lipid lowering, oral antidiabetic drugs and antidepressants) were not associated with high galectin-3. Conclusions This is the first study to show an association between depression and galectin-3. Depression was the only explored parameter associated with high circulating galectin-3 levels in 283 T1D patients. High galectin-3 levels might contribute to the increased risk for Alzheimer’s disease, cardiovascular and all-cause mortality observed in persons with depression. Potentially, in the future, treatment targeting galactin-3 might improve the prognosis for patients with high galectin-3 levels. PMID:29760188

On unravelling mechanism of interplay between cloud and large scale circulation: a grey area in climate science

NASA Astrophysics Data System (ADS)

De, S.; Agarwal, N. K.; Hazra, Anupam; Chaudhari, Hemantkumar S.; Sahai, A. K.

2018-04-01

The interaction between cloud and large scale circulation is much less explored area in climate science. Unfolding the mechanism of coupling between these two parameters is imperative for improved simulation of Indian summer monsoon (ISM) and to reduce imprecision in climate sensitivity of global climate model. This work has made an effort to explore this mechanism with CFSv2 climate model experiments whose cloud has been modified by changing the critical relative humidity (CRH) profile of model during ISM. Study reveals that the variable CRH in CFSv2 has improved the nonlinear interactions between high and low frequency oscillations in wind field (revealed as internal dynamics of monsoon) and modulates realistically the spatial distribution of interactions over Indian landmass during the contrasting monsoon season compared to the existing CRH profile of CFSv2. The lower tropospheric wind error energy in the variable CRH simulation of CFSv2 appears to be minimum due to the reduced nonlinear convergence of error to the planetary scale range from long and synoptic scales (another facet of internal dynamics) compared to as observed from other CRH experiments in normal and deficient monsoons. Hence, the interplay between cloud and large scale circulation through CRH may be manifested as a change in internal dynamics of ISM revealed from scale interactive quasi-linear and nonlinear kinetic energy exchanges in frequency as well as in wavenumber domain during the monsoon period that eventually modify the internal variance of CFSv2 model. Conversely, the reduced wind bias and proper modulation of spatial distribution of scale interaction between the synoptic and low frequency oscillations improve the eastward and northward extent of water vapour flux over Indian landmass that in turn give feedback to the realistic simulation of cloud condensates attributing improved ISM rainfall in CFSv2.

Silver Peak Innovative Exploration Project (Ram Power Inc.)

DOE Data Explorer

Miller, Clay

2010-01-01

Data generated from the Silver Peak Innovative Exploration Project, in Esmeralda County, Nevada, encompasses a “deep-circulation (amagmatic)” meteoric-geothermal system circulating beneath basin-fill sediments locally blanketed with travertine in western Clayton Valley (lithium-rich brines from which have been mined for several decades). Spring- and shallow-borehole thermal-water geochemistry and geothermometry suggest that a Silver Peak geothermal reservoir is very likely to attain the temperature range 260- 300oF (~125-150oC), and may reach 300-340oF (~150-170oC) or higher (GeothermEx, Inc., 2006). Results of detailed geologic mapping, structural analysis, and conceptual modeling of the prospect (1) support the GeothermEx (op. cit.) assertion that the Silver Peak prospect has good potential for geothermal-power production; and (2) provide a theoretical geologic framework for further exploration and development of the resource. The Silver Peak prospect is situated in the transtensional (regional shearing coupled with extension) Walker Lane structural belt, and squarely within the late Miocene to Pliocene (11 Ma to ~5 Ma) Silver Peak-Lone Mountain metamorphic core complex (SPCC), a feature that accommodated initial displacement transfer between major right-lateral strike- slip fault zones on opposite sides of the Walker Lane. The SPCC consists essentially of a ductiley-deformed lower plate, or “core,” of Proterozoic metamorphic tectonites and tectonized Mesozoic granitoids separated by a regionally extensive, low-angle detachment fault from an upper plate of severely stretched and fractured structural slices of brittle, Proterozoic to Miocene-age lithologies. From a geothermal perspective, the detachment fault itself and some of the upper-plate structural sheets could function as important, if secondary, subhorizontal thermal-fluid aquifers in a Silver Peak hydrothermal system.

Short ensembles: An Efficient Method for Discerning Climate-relevant Sensitivities in Atmospheric General Circulation Models

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wan, Hui; Rasch, Philip J.; Zhang, Kai

2014-09-08

This paper explores the feasibility of an experimentation strategy for investigating sensitivities in fast components of atmospheric general circulation models. The basic idea is to replace the traditional serial-in-time long-term climate integrations by representative ensembles of shorter simulations. The key advantage of the proposed method lies in its efficiency: since fewer days of simulation are needed, the computational cost is less, and because individual realizations are independent and can be integrated simultaneously, the new dimension of parallelism can dramatically reduce the turnaround time in benchmark tests, sensitivities studies, and model tuning exercises. The strategy is not appropriate for exploring sensitivitymore » of all model features, but it is very effective in many situations. Two examples are presented using the Community Atmosphere Model version 5. The first example demonstrates that the method is capable of characterizing the model cloud and precipitation sensitivity to time step length. A nudging technique is also applied to an additional set of simulations to help understand the contribution of physics-dynamics interaction to the detected time step sensitivity. In the second example, multiple empirical parameters related to cloud microphysics and aerosol lifecycle are perturbed simultaneously in order to explore which parameters have the largest impact on the simulated global mean top-of-atmosphere radiation balance. Results show that in both examples, short ensembles are able to correctly reproduce the main signals of model sensitivities revealed by traditional long-term climate simulations for fast processes in the climate system. The efficiency of the ensemble method makes it particularly useful for the development of high-resolution, costly and complex climate models.« less

Exploring Pacific Climate Variability and Its Impacts on East African Water Resources and Food Security

NASA Astrophysics Data System (ADS)

Funk, C. C.; Hoerling, M. P.; Hoell, A.; Liebmann, B.; Verdin, J. P.; Eilerts, G.

2014-12-01

In 8 out the past 15 boreal springs (1999, 2000, 2004, 2008, 2009, 2011, 2012, and 2013), substantial parts of eastern East Africa experienced very low boreal spring rains. These rainfall deficits have triggered widespread food insecurity, and even contributed to the outbreak of famine conditions in Somalia in 2011. At both seasonal and decadal time scales, new science supported by the USAID Famine Early Warning Systems Network seeks to understand the mechanisms producing these droughts. We present research suggesting that the ultimate and proximate causes of these increases in aridity are i) stronger equatorial Pacific SST gradients and ii) associated increases in the strength of the Indo-Pacific Walker circulation. Using observations and new modeling ensembles, we explore the relative contributions of Pacific Decadal Variability (PDV) and global warming under warm and cold east Pacific Ocean states. This question is addressed in two ways: by using atmospheric GCMs forced with full and ENSO-only SSTs, and ii) by decomposing coupled ocean-atmosphere climate simulations into PDV and non-PDV components. These analyses allow us to explore the Walker circulation's sensitivity to climate change under various PDV states, and inform a tentative bracketing of 2030 climate conditions. We conclude by discussing links to East African development. Regions of high rainfall sensitivity are delineated and intersected with recent changes in population and land cover/land use. The interaction of elevation and climate is shown to create climatically secure regions that are likely to remain viable even under drier and warmer conditions; such regions may be logical targets for agricultural intensification. Conversely, arid low elevation regions are likely to experience substantial temperature impacts. Continued expansion into these areas may effectively create more 'drought' even if rainfall increases.

Combined influence of meso-scale circulation and bathymetry on the foraging behaviour of a diving predator, the king penguin (Aptenodytes patagonicus)

NASA Astrophysics Data System (ADS)

Scheffer, Annette; Trathan, Philip N.; Edmonston, Johnnie G.; Bost, Charles-André

2016-02-01

Investigating the responses of marine predators to environmental features is of key importance for understanding their foraging behaviour and reproductive success. In this study we examined the foraging behaviour of king penguins breeding at Kerguelen (southern Indian Ocean) in relation to oceanographic and bathymetric features within their foraging ambit. We used ARGOS and Global Positioning System tracking together with Time-Depth-Temperature-Recorders (TDR) to follow the at-sea movements of incubating and brooding king penguins. Combining the penguin behaviour with oceanographic data at the surface through satellite data and at depth through in-situ recordings by the TDRs enabled us to explore how these predators adjusted their horizontal and vertical foraging movements in response to their physical environment. Relating the observed behaviour and oceanographic patterns to local bathymetry lead to a comprehensive picture of the combined influence of bathymetry and meso-scale circulation on the foraging behaviour of king penguins. During both breeding stages king penguins foraged in the area to the south-east of Kerguelen, where they explored an influx of cold waters of southern origin interacting with the Kerguelen Plateau bathymetry. Foraging in the Polar Front and at the thermocline was associated with high prey capture rates. However, foraging trip orientation and water mass utilization suggested that bathymetrically entrained cold-water features provided the most favourable foraging locations. Our study explicitly reports the exploration of bathymetry-related oceanographic features by foraging king penguins. It confirms the presence of Areas of Ecological Significance for marine predators on the Kerguelen Plateau, and suggests the importance of further areas related to the cold-water flow along the shelf break of the Kerguelen Plateau.

Exploring a deep meridional flow hypothesis for a circulation dominated solar dynamo model

NASA Astrophysics Data System (ADS)

Guerrero, G. A.; Muñoz, J. D.; de Gouveia dal Pino, E. M.

2005-09-01

Circulation-dominated solar dynamo models, which employ a helioseismic rotation profile and a fixed meridional flow, give a good approximation to the large scale solar magnetic phenomena, such as the 11-year cycle or the so called Hale's law of polarities. Nevertheless, the larger amplitude of the radial shear ∂Ω/∂r at the high latitudes makes the dynamo to produce a strong toroidal magnetic field at high latitudes, in contradiction with the observations of the sunspots (Sporer's Law). A possible solution was proposed by Nandy and Choudhuri in which a deep meridional flow can conduct the magnetic field inside of a stable layer (the radiative core) and then allow that it erupts just at lower latitudes. Although they obtain good results, this hypothesis generates new problems like the mixture of elements in the radiative core (that alters the abundance of the elements) and the transfer of angular momentum. We have recently explored this hypothesis in a different approximation, using the magnetic buoyancy mechanism proposed by Dikpati and Charbonneau (1999) and found that a deep meridional flow pushes the maximum of the toroidal magnetic field towards the solar equator, but, in contrast to Nandy and Choudhuri (2002 ), a second zone of maximum fields remains at the poles. In that work, we have also introduced a bipolytropic density profile in order to better reproduce the stratification in the radiative zone. We here review these results and also discuss a new possible scenario where the tachocline has an ellipsoidal shape, following early helioseismologic observations, and find that the modification of the geometry of the tachocline can lead to results which are in good agreement with observations and opens the possibility to explore in more detail, through the dynamo model, the place where the magnetic field could be really stored.

Towards a Better Understanding of the Venus Atmosphere - Observations needed between 65 - 120 km

NASA Astrophysics Data System (ADS)

Limaye, S. S.; Clancy, R. T.; Rengel, M.; Sorning, M.

2013-12-01

Through a half century of exploring Venus with spacecraft, we have learned that the planet and its atmos-phere continue to hold many mysteries. The ubiquitous clouds contain one or more particulate or gaseous spe-cies which absorb much of the incident UV solar radiation. While there are some candidates, the identity and physical properties of the UV absorber are unknown. Energy emitted by the surface and lower atmosphere es-capes through small- and large-scale inhomogeneities in opacity in the near-infrared region of the spectrum, and thus a better knowledge of the UV absorber distribution and Venus clouds are needed to understand the energy balance which drives the atmospheric circulation. First-principles postulates predicted a global day-side to night-side circulation for the entire atmosphere, but subsequent measurements show that this exists only in the 90-120 km layer and superrotation is present throughout the atmosphere below. However, systematic measure-ments are lacking and details of the day-night circulation are very sketchy. Döppler observations at (emitted) infrared [1] and reflected visible [2] wavelengths and imaging observa-tions at near infrared wavelengths from telescopes and spacecraft [3] provide insights into the circulation, above, near and below the cloud tops, but much less is known about the winds in the lower atmosphere. Recent efforts by many groups have been able to achieve some resemblance between the model results and some aspects of observed circulation. The different models disagree on the details and the processes for the maintenance of the circulation [4]. One of the dominant problems inhibiting further progress is uncertainty in the distribution of heating by absorbed solar energy and thermal radiation emitted from the lower atmosphere and surface [5], and a better understanding of the nature of the ultraviolet absorber will help. Only Döppler measurements are possible to learn about the circulation above the cloud tops but provide only line of sight component and so far have been made only from ground based telescopes. The results show sub-stantial variability on long and short time scales and until recently were generally focused more on the zonal circulation and less on the day-night circulation. Spacecraft observations from orbit may be necessary to learn more about the sub-solar to anti-solar circulation that is inferred from the night glow observations. Ground based Döppler observations covering the entire planet and the day and night limb with sufficient spatial resolu-tion will also help to better characterize the atmospheric circulation above the cloudtops to ~ 120 km. In-situ sampling may be necessary to confirm the identity of the ultraviolet absorber(s) in the clouds to better under-stand the global energy deposition and loss from the Venus atmosphere. References: [1] Limaye, S.; Rengel, M., 2013, Int. Space Studies Inst., Bern, Switzerland, Report # 11, 55-72, [2] Machado, P. et al., 2012, , Icarus 221, 248-261. [8] Taylor et al., (1997) Venus II, 325-351. [3] Sánchez-Lavega et al., (2008) Geophys. Res. Lett., 35, L13204, doi: 10.1029/2008GL033817. [4] Lebonnois et al. , 2013, Intl. Space Studies Inst., Bern, Switzerland, Report # 11, 129-156. [5]Titov et al. , 2013, Intl. Space Studies Inst., Bern, Switzerland, Report # 11, 23-54.

Is It Time to Say Farewell to the ISDS System?

PubMed Central

Lencucha, Raphael

2017-01-01

Investor-state dispute settlement (ISDS) continues to plague health-oriented government regulation. This is particularly reflected in recent challenges to tobacco control measures through bilateral investment agreements. There are numerous reform proposals circulating within the public health community. However, I suggest that perhaps it is time for the community to explore a stronger position on ISDS. I draw from mounting evidence on the problematic uses of the ISDS to explore the proposition that ISDS is no longer justified. I tackle the normative question of should the ISDS system persist and point out that the ISDS system is not justifiable from a development perspective and because of its nefarious use, is of no added value to a system that could rely on domestic courts. PMID:28812817

The COST733 circulation type classification software: an example for surface ozone concentrations in Central Europe

NASA Astrophysics Data System (ADS)

Demuzere, Matthias; Kassomenos, P.; Philipp, A.

2011-08-01

In the framework of the COST733 Action "Harmonisation and Applications of Weather Types Classifications for European Regions" a new circulation type classification software (hereafter, referred to as cost733class software) is developed. The cost733class software contains a variety of (European) classification methods and is flexible towards choice of domain of interest, input variables, time step, number of circulation types, sequencing and (weighted) target variables. This work introduces the capabilities of the cost733class software in which the resulting circulation types (CTs) from various circulation type classifications (CTCs) are applied on observed summer surface ozone concentrations in Central Europe. Firstly, the main characteristics of the CTCs in terms of circulation pattern frequencies are addressed using the baseline COST733 catalogue (cat 2.0), at present the latest product of the new cost733class software. In a second step, the probabilistic Brier skill score is used to quantify the explanatory power of all classifications in terms of the maximum 8 hourly mean ozone concentrations exceeding the 120-μg/m3 threshold; this was based on ozone concentrations from 130 Central European measurement stations. Averaged evaluation results over all stations indicate generally higher performance of CTCs with a higher number of types. Within the subset of methodologies with a similar number of types, the results suggest that the use of CTCs based on optimisation algorithms are performing slightly better than those which are based on other algorithms (predefined thresholds, principal component analysis and leader algorithms). The results are further elaborated by exploring additional capabilities of the cost733class software. Sensitivity experiments are performed using different domain sizes, input variables, seasonally based classifications and multiple-day sequencing. As an illustration, CTCs which are also conditioned towards temperature with various weights are derived and tested similarly. All results exploit a physical interpretation by adapting the environment-to-circulation approach, providing more detailed information on specific synoptic conditions prevailing on days with high surface ozone concentrations. This research does not intend to bring forward a favourite classification methodology or construct a statistical ozone forecasting tool but should be seen as an introduction to the possibilities of the cost733class software. It this respect, the results presented here can provide a basic user support for the cost733class software and the development of a more user- or application-specific CTC approach.

Responses of ocean circulation and carbon cycle to changes in the position of the Southern Hemisphere westerlies at Last Glacial Maximum

PubMed Central

Völker, Christoph; Köhler, Peter

2013-01-01

We explore the impact of a latitudinal shift in the westerly wind belt over the Southern Ocean on the Atlantic meridional overturning circulation (AMOC) and on the carbon cycle for Last Glacial Maximum background conditions using a state-of-the-art ocean general circulation model. We find that a southward (northward) shift in the westerly winds leads to an intensification (weakening) of no more than 10% of the AMOC. This response of the ocean physics to shifting winds agrees with other studies starting from preindustrial background climate, but the responsible processes are different. In our setup changes in AMOC seemed to be more pulled by upwelling in the south than pushed by downwelling in the north, opposite to what previous studies with different background climate are suggesting. The net effects of the changes in ocean circulation lead to a rise in atmospheric pCO2 of less than 10 μatm for both northward and southward shift in the winds. For northward shifted winds the zone of upwelling of carbon- and nutrient-rich waters in the Southern Ocean is expanded, leading to more CO2outgassing to the atmosphere but also to an enhanced biological pump in the subpolar region. For southward shifted winds the upwelling region contracts around Antarctica, leading to less nutrient export northward and thus a weakening of the biological pump. These model results do not support the idea that shifts in the westerly wind belt play a dominant role in coupling atmospheric CO2 rise and Antarctic temperature during deglaciation suggested by the ice core data. PMID:26074663

Responses of ocean circulation and carbon cycle to changes in the position of the Southern Hemisphere westerlies at Last Glacial Maximum.

PubMed

Völker, Christoph; Köhler, Peter

2013-12-01

We explore the impact of a latitudinal shift in the westerly wind belt over the Southern Ocean on the Atlantic meridional overturning circulation (AMOC) and on the carbon cycle for Last Glacial Maximum background conditions using a state-of-the-art ocean general circulation model. We find that a southward (northward) shift in the westerly winds leads to an intensification (weakening) of no more than 10% of the AMOC. This response of the ocean physics to shifting winds agrees with other studies starting from preindustrial background climate, but the responsible processes are different. In our setup changes in AMOC seemed to be more pulled by upwelling in the south than pushed by downwelling in the north, opposite to what previous studies with different background climate are suggesting. The net effects of the changes in ocean circulation lead to a rise in atmospheric p CO 2 of less than 10 μatm for both northward and southward shift in the winds. For northward shifted winds the zone of upwelling of carbon- and nutrient-rich waters in the Southern Ocean is expanded, leading to more CO 2 outgassing to the atmosphere but also to an enhanced biological pump in the subpolar region. For southward shifted winds the upwelling region contracts around Antarctica, leading to less nutrient export northward and thus a weakening of the biological pump. These model results do not support the idea that shifts in the westerly wind belt play a dominant role in coupling atmospheric CO 2 rise and Antarctic temperature during deglaciation suggested by the ice core data.

Assessing Northern Hemisphere Land-Atmosphere Hotspots Using Dynamical Adjustment

NASA Astrophysics Data System (ADS)

Merrifield, Anna; Lehner, Flavio; Deser, Clara; Xie, Shang-Ping

2017-04-01

Understanding the influence of soil moisture on surface air temperature (SAT) is made more challenging by large-scale, internal atmospheric variability present in the midlatitude summer atmosphere. In this study, dynamical adjustment is used to characterize and remove summer SAT variability associated with large-scale circulation patterns in the Community Earth System Model large ensemble (CESM-LE). The adjustment is performed over North America and Europe with two different circulation indicators: sea level pressure (SLP) and 500mb height (Z500). The removal of dynamical "noise" leaves residual SAT variability in the central U.S. and Mediterranean regions identified as hotspots of land-atmosphere interaction (e.g. Koster et al. 2004, Seneviratne et al. 2006). The residual SAT variability "signal" is not clearly related to modes of sea surface temperature (SST) variability, but is related to local soil moisture, evaporative fraction, and radiation availability. These local relationships suggest that residual SAT variability is representative of the aggregate land surface signal. SLP dynamical adjustment removes ˜15% more variability in the central U.S. hotspot region than Z500 dynamical adjustment. Similar amounts of variability are removed by SLP and Z500 in the Mediterranean region. Differences in SLP and Z500 signal magnitude in the central U.S. are likely due to the modification of SLP by local land surface conditions, while the proximity of European hotspots to the Mediterranean sea mitigates the land surface influence. Variations in the Z500 field more closely resemble large-scale midlatitude circulation patterns and therefore Z500 may be a more suitable circulation indicator for summer dynamical adjustment. Changes in the residual SAT variability signal under increased greenhouse gas forcing will also be explored.

Blood transcriptomic comparison of individuals with and without autism spectrum disorder: A combined-samples mega-analysis.

PubMed

Tylee, Daniel S; Hess, Jonathan L; Quinn, Thomas P; Barve, Rahul; Huang, Hailiang; Zhang-James, Yanli; Chang, Jeffrey; Stamova, Boryana S; Sharp, Frank R; Hertz-Picciotto, Irva; Faraone, Stephen V; Kong, Sek Won; Glatt, Stephen J

2017-04-01

Blood-based microarray studies comparing individuals affected with autism spectrum disorder (ASD) and typically developing individuals help characterize differences in circulating immune cell functions and offer potential biomarker signal. We sought to combine the subject-level data from previously published studies by mega-analysis to increase the statistical power. We identified studies that compared ex vivo blood or lymphocytes from ASD-affected individuals and unrelated comparison subjects using Affymetrix or Illumina array platforms. Raw microarray data and clinical meta-data were obtained from seven studies, totaling 626 affected and 447 comparison subjects. Microarray data were processed using uniform methods. Covariate-controlled mixed-effect linear models were used to identify gene transcripts and co-expression network modules that were significantly associated with diagnostic status. Permutation-based gene-set analysis was used to identify functionally related sets of genes that were over- and under-expressed among ASD samples. Our results were consistent with diminished interferon-, EGF-, PDGF-, PI3K-AKT-mTOR-, and RAS-MAPK-signaling cascades, and increased ribosomal translation and NK-cell related activity in ASD. We explored evidence for sex-differences in the ASD-related transcriptomic signature. We also demonstrated that machine-learning classifiers using blood transcriptome data perform with moderate accuracy when data are combined across studies. Comparing our results with those from blood-based studies of protein biomarkers (e.g., cytokines and trophic factors), we propose that ASD may feature decoupling between certain circulating signaling proteins (higher in ASD samples) and the transcriptional cascades which they typically elicit within circulating immune cells (lower in ASD samples). These findings provide insight into ASD-related transcriptional differences in circulating immune cells. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

Technical Insights into Highly Sensitive Isolation and Molecular Characterization of Fixed and Live Circulating Tumor Cells for Early Detection of Tumor Invasion.

PubMed

Laget, Sophie; Broncy, Lucile; Hormigos, Katia; Dhingra, Dalia M; BenMohamed, Fatima; Capiod, Thierry; Osteras, Magne; Farinelli, Laurent; Jackson, Stephen; Paterlini-Bréchot, Patrizia

2017-01-01

Circulating Tumor Cells (CTC) and Circulating Tumor Microemboli (CTM) are Circulating Rare Cells (CRC) which herald tumor invasion and are expected to provide an opportunity to improve the management of cancer patients. An unsolved technical issue in the CTC field is how to obtain highly sensitive and unbiased collection of these fragile and heterogeneous cells, in both live and fixed form, for their molecular study when they are extremely rare, particularly at the beginning of the invasion process. We report on a new protocol to enrich from blood live CTC using ISET® (Isolation by SizE of Tumor/Trophoblastic Cells), an open system originally developed for marker-independent isolation of fixed tumor cells. We have assessed the impact of our new enrichment method on live tumor cells antigen expression, cytoskeleton structure, cell viability and ability to expand in culture. We have also explored the ISET® in vitro performance to collect intact fixed and live cancer cells by using spiking analyses with extremely low number of fluorescent cultured cells. We describe results consistently showing the feasibility of isolating fixed and live tumor cells with a Lower Limit of Detection (LLOD) of one cancer cell per 10 mL of blood and a sensitivity at LLOD ranging from 83 to 100%. This very high sensitivity threshold can be maintained when plasma is collected before tumor cells isolation. Finally, we have performed a comparative next generation sequencing (NGS) analysis of tumor cells before and after isolation from blood and culture. We established the feasibility of NGS analysis of single live and fixed tumor cells enriched from blood by our system. This study provides new protocols for detection and characterization of CTC collected from blood at the very early steps of tumor invasion.

Circulating nucleic acids damage DNA of healthy cells by integrating into their genomes

PubMed Central

Mittra, Indraneel; Khare, Naveen Kumar; Raghuram, Gorantla Venkata; Chaubal, Rohan; Khambatti, Fatema; Gupta, Deepika; Gaikwad, Ashwini; Prasannan, Preeti; Singh, Akshita; Iyer, Aishwarya; Singh, Ankita; Upadhyay, Pawan; Nair, Naveen Kumar; Mishra, Pradyumna Kumar; Dutt, Amit

2018-01-01

Whether nucleic acids that circulate in blood have any patho-physiological functions in the host have not been explored. We report here that far from being inert molecules, circulating nucleic acids have significant biological activities of their own that are deleterious to healthy cells of the body. Fragmented DNA and chromatin (DNAfs and Cfs) isolated from blood of cancer patients and healthy volunteers are readily taken up by a variety of cells in culture to be localized in their nuclei within a few minutes. The intra-nuclear DNAfs and Cfs associate themselves with host cell chromosomes to evoke a cellular DNA-damage-repair-response (DDR) followed by their incorporation into the host cell genomes. Whole genome sequencing detected the presence of tens of thousands of human sequence reads in the recipient mouse cells. Genomic incorporation of DNAfs and Cfs leads to dsDNA breaks and activation of apoptotic pathways in the treated cells. When injected intravenously into Balb/C mice, DNAfs and Cfs undergo genomic integration into cells of their vital organs resulting in activation of DDR and apoptotic proteins in the recipient cells. Cfs have significantly greater activity than DNAfs with respect to all parameters examined, while both DNAfs and Cfs isolated from cancer patients are more active than those from normal volunteers. All the above pathological actions of DNAfs and Cfs described above can be abrogated by concurrent treatment with DNase I and/or anti-histone antibody complexed nanoparticles both in vitro and in vivo. Taken together, our results that circulating DNAfs and Cfs are physiological, continuously arising, endogenous DNA damaging agents with implications to ageing and a multitude of human pathologies including initiation of cancer. PMID:25740145

Anticipatory and consummatory effects of (hedonic) chocolate intake are associated with increased circulating levels of the orexigenic peptide ghrelin and endocannabinoids in obese adults.

PubMed

Rigamonti, Antonello E; Piscitelli, Fabiana; Aveta, Teresa; Agosti, Fiorenza; De Col, Alessandra; Bini, Silvia; Cella, Silvano G; Di Marzo, Vincenzo; Sartorio, Alessandro

2015-01-01

Hedonic hunger refers to consumption of food just for pleasure and not to maintain energy homeostasis. Recently, consumption of food for pleasure was reported to be associated with increased circulating levels of both the orexigenic peptide ghrelin and the endocannabinoid 2-arachidonoyl-glycerol (2-AG) in normal-weight subjects. To date, the effects of hedonic hunger, and in particular of chocolate craving, on these mediators in obese subjects are still unknown. To explore the role of some gastrointestinal orexigenic and anorexigenic peptides and endocannabinoids (and some related congeners) in chocolate consumption, we measured changes in circulating levels of ghrelin, glucagon-like peptide 1 (GLP-1), peptide YY (PYY), anandamide (AEA), 2-AG, palmitoylethanolamide (PEA), and oleoylethanolamide (OEA) in 10 satiated severely obese subjects after consumption of chocolate and, on a separate day, of a non-palatable isocaloric food with the same bromatologic composition. Evaluation of hunger and satiety was also performed by visual analogic scale. The anticipatory phase and the consumption of food for pleasure were associated with increased circulating levels of ghrelin, AEA, 2-AG, and OEA. In contrast, the levels of GLP-1, PYY, and PEA did not differ before and after the exposure/ingestion of either chocolate or non-palatable foods. Hunger and satiety were higher and lower, respectively, in the hedonic session than in the non-palatable one. When motivation to eat is generated by exposure to, and consumption of, chocolate a peripheral activation of specific endogenous rewarding chemical signals, including ghrelin, AEA, and 2-AG, is observed in obese subjects. Although preliminary, these findings predict the effectiveness of ghrelin and endocannabinoid antagonists in the treatment of obesity.

A unique set of 6 circulating microRNAs for early detection of non-small cell lung cancer.

PubMed

Halvorsen, Ann Rita; Bjaanæs, Maria; LeBlanc, Marissa; Holm, Are M; Bolstad, Nils; Rubio, Luis; Peñalver, Juan Carlos; Cervera, José; Mojarrieta, Julia Cruz; López-Guerrero, Jose Antonio; Brustugun, Odd Terje; Helland, Åslaug

2016-06-14

Circulating microRNAs are promising biomarkers for diagnosis, predication and prognostication of diseases. Lung cancer is the cancer disease accountable for most cancer deaths, largely due to being diagnosed at late stages. Therefore, diagnosing lung cancer patients at an early stage is crucial for improving the outcome. The purpose of this study was to identify circulating microRNAs for detection of early stage lung cancer, capable of discriminating lung cancer patients from those with chronic obstructive pulmonary disease (COPD) and healthy volunteers. We identified 7 microRNAs separating lung cancer patients from controls. By using RT-qPCR, we validated 6 microRNAs (miR-429, miR-205, miR-200b, miR-203, miR-125b and miR-34b) with a significantly higher abundance in serum from NSCLC patients. Furthermore, the 6 miRNAs were validated in a different dataset, revealing an area under the receiver operating characteristic curve of 0.89 for stage I-IV and 0.88 for stage I/II. We profiled the expression of 754 unique microRNAs by TaqMan Low Density Arrays, and analyzed serum from 38 patients with NSCLC, 16 patients suffering from COPD and 16 healthy volunteers from Norway, to explore their potential as diagnostic biomarkers. For validation, we analyzed serum collected from high-risk individuals enrolled in the Valencia branch of the International Early Lung Cancer Action Program screening trial (n=107) in addition to 51 lung cancer patients. Considering the accessibility and stability of circulating miRNAs, these 6 microRNAs are promising biomarkers as a supplement in future screening studies.

Hedonic eating in Prader–Willi syndrome is associated with blunted PYY secretion

PubMed Central

Rigamonti, A. E.; Bini, S.; Piscitelli, F.; Lauritano, A.; Di Marzo, V.; Vanetti, C.; Agosti, F.; De Col, A.; Lucchetti, E.; Grugni, G.; Sartorio, A.

2017-01-01

ABSTRACT Hedonic and homeostatic hunger represent two different forms of eating: just for pleasure or following energy deprivation, respectively. Consumption of food for pleasure was reported to be associated with increased circulating levels of both the orexigenic peptide ghrelin and some specific endocannabinoids in normal-weight subjects and patients with morbid obesity. To date, the effects of palatable food on these mediators in Prader–Willi syndrome (PWS) are still unknown. To explore the role of some gastrointestinal orexigenic and anorexigenic peptides and endocannabinoids (and some related congeners) in chocolate consumption, we measured changes in circulating levels of ghrelin, cholecystokinin (CCK), peptide YY (PYY), anandamide (AEA), 2-arachidonoyl-glycerol (2-AG), palmitoylethanolamide (PEA) and oleoylethanolamide (OEA) in eight satiated adult PWS patients after consumption of chocolate and, on a separate day, of a non-palatable isocaloric food with the same macronutrient composition. Evaluation of hunger and satiety was also performed by visual analogic scale. The anticipatory phase and the consumption of food for pleasure were associated with decreased circulating levels of PYY. An increase in PEA levels was also observed. By contrast, circulating levels of ghrelin, CCK, AEA, 2-AG and OEA did not differ before and after the exposure/ingestion of either chocolate or non-palatable foods. Hunger and satiety were similar in the hedonic and non-palatable sessions. In conclusion, when motivation to eat is promoted by highly palatable foods, a depressed post-prandial PYY secretion is observed in PWS. Although preliminary, these findings seem to hypothesize a possible role of PYY agonists in the management of PWS patients. Abbreviations: AEA, Anandamide; 2-AG, 2-arachidonoyl-glycerol; CB1, cannabinoid receptor type 1; OEA, oleoylethanolamide; PEA, palmitoylethanolamide; PWS: Prader-Willi syndrome; VAS, visual analog scales PMID:28659728

Buoyancy forcing and the MOC: insights from experiments, simulations and global models

NASA Astrophysics Data System (ADS)

White, B. L.; Passaggia, P. Y.; Zemskova, V.

2017-12-01

The driving forces behind the Meridional Overturning Circulation (MOC) have been widely debated, with wind-driven upwelling, surface buoyancy fluxes due to heating/cooling/freshwater input, and vertical diffusion due to turbulent mixing all thought to play significant roles. To explore the specific role of buoyancy forcing we present results from experiments and simulations of Horizontal Convection (HC), where a circulation is driven by differential buoyancy forcing applied along a horizontal surface. We interpret these results using energy budgets based on the local Available Potential Energy framework introduced in [Scotti and White, J. Fluid Mech., 2014]. We first describe HC experiments driven by the diffusion of salt in water across membranes localized at the surface, at Schmidt numbers {Sc}≈ 610 and Rayleigh numbers in the range 1012 < Ra=Δ b L3/(ν κ ) < 1017, where ν is the kinematic viscosity of water, κ is the diffusion coefficient of salt, L=[.5,2,5]m is the length of the different tanks and Δ b=g(ρ salt}-ρ {fresh}/ρ_{fresh is the reduced gravity difference. We show that the scaling follows a Nu ˜ Ra1/4 type scaling recently theorized by Shishkina et; al. (2016). We then present numerical results for rotating horizontal convection with a zonally re-entrant channel to represent the Southern Ocean branch of the MOC. While the zonal wind stress profile is important to the spatial pattern of the circulation, perhaps surprisingly, the energy budget shows only a weak dependence on the magnitude of the wind input, suggesting that surface APE generation by buoyancy forcing is dominant in driving the overturning circulation.

Dynamics of Cross-Shore Thermal Exchange Over Nonuniform Bathymetry

NASA Astrophysics Data System (ADS)

Safaie, A.; Davis, K. A.; Pawlak, G. R.

2016-02-01

The hydrodynamics of cross-shelf circulation on the inner shelf influence coastal ecosystems through the transport of heat, salt, nutrients, and planktonic organisms. While cross-shelf exchange on wide continental shelves has received a fair amount of attention in literature, the mechanisms for cross-shelf exchange on narrow shelves with steep, rough, and highly irregular bathymetry, characteristic of coral reef shorelines, is not well understood. Previous observational studies from reefs at Eilat, Israel and Oahu, Hawaii, have demonstrated the importance of surface heat flux in driving cross-shore transport. While both sites experienced offshore surface flow during daytime warming periods and offshore flow near the bed during nighttime cooling, the phase differences between the surface heat fluxes and thermal responses at the two sites indicate different dynamic flow regimes based on momentum and thermal balances. This study examines the dynamical structure of thermally driven flows using numerical modeling to investigate the hypothesis that thermally driven baroclinic exchange is important to cross-shore circulation for tropical coastlines. We use the open-source Regional Ocean Modeling System (ROMS), a free-surface, three-dimensional circulation model, considering a simple wedge case with uniform bathymetry in the alongshore direction, and heat flux applied uniformly to the surface. We examine different flow regimes using scaling of the momentum and thermal balance equations. We also explore the parameter space for the momentum balance describing cross-shore thermal exchange, and thoroughly characterize the exchange structure by investigating the dominant forcing regimes, the mechanisms responsible for modulating thermal circulation, and the effects of temporal variations in vertical mixing and heating/cooling buoyancy flux. Results are compared against existing data sets to evaluate the ability of the model to represent these flows.

Anticipatory and consummatory effects of (hedonic) chocolate intake are associated with increased circulating levels of the orexigenic peptide ghrelin and endocannabinoids in obese adults

PubMed Central

Rigamonti, Antonello E.; Piscitelli, Fabiana; Aveta, Teresa; Agosti, Fiorenza; De Col, Alessandra; Bini, Silvia; Cella, Silvano G.; Di Marzo, Vincenzo; Sartorio, Alessandro

2015-01-01

Background Hedonic hunger refers to consumption of food just for pleasure and not to maintain energy homeostasis. Recently, consumption of food for pleasure was reported to be associated with increased circulating levels of both the orexigenic peptide ghrelin and the endocannabinoid 2-arachidonoyl-glycerol (2-AG) in normal-weight subjects. To date, the effects of hedonic hunger, and in particular of chocolate craving, on these mediators in obese subjects are still unknown. Methods To explore the role of some gastrointestinal orexigenic and anorexigenic peptides and endocannabinoids (and some related congeners) in chocolate consumption, we measured changes in circulating levels of ghrelin, glucagon-like peptide 1 (GLP-1), peptide YY (PYY), anandamide (AEA), 2-AG, palmitoylethanolamide (PEA), and oleoylethanolamide (OEA) in 10 satiated severely obese subjects after consumption of chocolate and, on a separate day, of a non-palatable isocaloric food with the same bromatologic composition. Evaluation of hunger and satiety was also performed by visual analogic scale. Results The anticipatory phase and the consumption of food for pleasure were associated with increased circulating levels of ghrelin, AEA, 2-AG, and OEA. In contrast, the levels of GLP-1, PYY, and PEA did not differ before and after the exposure/ingestion of either chocolate or non-palatable foods. Hunger and satiety were higher and lower, respectively, in the hedonic session than in the non-palatable one. Conclusions When motivation to eat is generated by exposure to, and consumption of, chocolate a peripheral activation of specific endogenous rewarding chemical signals, including ghrelin, AEA, and 2-AG, is observed in obese subjects. Although preliminary, these findings predict the effectiveness of ghrelin and endocannabinoid antagonists in the treatment of obesity. PMID:26546790

Blood Transcriptomic Comparison of Individuals with and without Autism Spectrum Disorder: A Combined-Samples Mega-Analysis

PubMed Central

Tylee, Daniel S.; Hess, Jonathan L.; Quinn, Thomas P.; Barve, Rahul; Huang, Hailiang; Zhang-James, Yanli; Chang, Jeffrey; Stamova, Boryana S.; Sharp, Frank R.; Hertz-Picciotto, Irva; Faraone, Stephen V.; Kong, Sek Won; Glatt, Stephen J.

2017-01-01

Blood-based microarray studies comparing individuals affected with autism spectrum disorder (ASD) and typically developing individuals help characterize differences in circulating immune cell functions and offer potential biomarker signal. We sought to combine the subject-level data from previously published studies by mega-analysis to increase the statistical power. We identified studies that compared ex-vivo blood or lymphocytes from ASD-affected individuals and unrelated comparison subjects using Affymetrix or Illumina array platforms. Raw microarray data and clinical meta-data were obtained from seven studies, totaling 626 affected and 447 comparison subjects. Microarray data were processed using uniform methods. Covariate-controlled mixed-effect linear models were used to identify gene transcripts and co-expression network modules that were significantly associated with diagnostic status. Permutation-based gene-set analysis was used to identify functionally related sets of genes that were over- and under-expressed among ASD samples. Our results were consistent with diminished interferon-, EGF-, PDGF-, PI3K-AKT-mTOR-, and RAS-MAPK-signaling cascades, and increased ribosomal translation and NK-cell related activity in ASD. We explored evidence for sex-differences in the ASD-related transcriptomic signature. We also demonstrated that machine-learning classifiers using blood transcriptome data perform with moderate accuracy when data are combined across studies. Comparing our results with those from blood-based studies of protein biomarkers (e.g., cytokines and trophic factors), we propose that ASD may feature decoupling between certain circulating signaling proteins (higher in ASD samples) and the transcriptional cascades which they typically elicit within circulating immune cells (lower in ASD samples). These findings provide insight into ASD-related transcriptional differences in circulating immune cells. PMID:27862943

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kataria, T.; Showman, A. P.; Fortney, J. J.

We present three-dimensional atmospheric circulation models of GJ 1214b, a 2.7 Earth-radius, 6.5 Earth-mass super Earth detected by the MEarth survey. Here we explore the planet's circulation as a function of atmospheric metallicity and atmospheric composition, modeling atmospheres with a low mean molecular weight (MMW; i.e., H{sub 2}-dominated) and a high MMW (i.e., water- and CO{sub 2}-dominated). We find that atmospheres with a low MMW have strong day-night temperature variations at pressures above the infrared photosphere that lead to equatorial superrotation. For these atmospheres, the enhancement of atmospheric opacities with increasing metallicity lead to shallower atmospheric heating, larger day-night temperaturemore » variations, and hence stronger superrotation. In comparison, atmospheres with a high MMW have larger day-night and equator-to-pole temperature variations than low MMW atmospheres, but differences in opacity structure and energy budget lead to differences in jet structure. The circulation of a water-dominated atmosphere is dominated by equatorial superrotation, while the circulation of a CO{sub 2}-dominated atmosphere is instead dominated by high-latitude jets. By comparing emergent flux spectra and light curves for 50× solar and water-dominated compositions, we show that observations in emission can break the degeneracy in determining the atmospheric composition of GJ 1214b. The variation in opacity with wavelength for the water-dominated atmosphere leads to large phase variations within water bands and small phase variations outside of water bands. The 50× solar atmosphere, however, yields small variations within water bands and large phase variations at other characteristic wavelengths. These observations would be much less sensitive to clouds, condensates, and hazes than transit observations.« less

From tissue iron retention to low systemic haemoglobin levels, new pathophysiological biomarkers of human abdominal aortic aneurysm.

PubMed

Martinez-Pinna, R; Lindholt, J S; Madrigal-Matute, J; Blanco-Colio, L M; Esteban-Salan, M; Torres-Fonseca, M M; Lefebvre, T; Delbosc, S; Laustsen, J; Driss, F; Vega de Ceniga, M; Gouya, L; Weiss, G; Egido, J; Meilhac, O; Michel, J-B; Martin-Ventura, J

2014-07-03

Iron deposits are observed in tissue of abdominal aortic aneurysm (AAA) patients, although the underlying mechanisms are not completely elucidated. Therefore we explored circulating markers of iron metabolism in AAA patients, and tested if they could serve as biomarkers of AAA. Increased red blood cell (RBC)-borne iron retention and transferrin, transferrin receptor and ferritin expression was observed in AAA tissue compared to control aorta (immunohistochemistry and western blot). In contrast, decreased circulating iron, transferrin, mean corpuscular haemoglobin concentration (MCHC) and haemoglobin concentration, along with circulating RBC count, were observed in AAA patients (aortic diameter >3 cm, n=114) compared to controls (aortic diameter <3 cm, n=88) (ELISA), whereas hepcidin concentrations were increased in AAA subjects (MS/MS assay). Moreover, iron, transferrin and haemoglobin levels were negatively, and hepcidin positively, correlated with aortic diameter in AAA patients. The association of low haemoglobin with AAA presence or aortic diameter was independent of specific risk factors. Moreover, MCHC negatively correlated with thrombus area in another cohort of AAA patients (aortic diameter 3-5 cm, n=357). We found that anaemia was significantly more prevalent in AAA patients (aortic diameter >5 cm, n=8,912) compared to those in patients with atherosclerotic aorto-iliac occlusive disease (n=17,737) [adjusted odds ratio=1.77 (95% confidence interval: 1.61;1.93)]. Finally, the mortality risk among AAA patients with anaemia was increased by almost 30% [adjusted hazard ratio: 1.29 (95% confidence interval: 1.16;1.44)] as compared to AAA subjects without anaemia. In conclusion, local iron retention and altered iron recycling associated to high hepcidin and low transferrin systemic concentrations could lead to reduced circulating haemoglobin levels in AAA patients. Low haemoglobin levels are independently associated to AAA presence and clinical outcome.

Satellite Nighttime Imagery Assists in Flossie Track

NASA Image and Video Library

2017-12-08

The enhanced capabilities of the Suomi NPP satellite's day-night band are really becoming clear, as was seen this week when Tropical Storm Flossie was heading toward Hawaii. On Monday, July 29th, the lack of organization of the system made it difficult to understand the storm’s central circulation. Infrared data, though able to provide cloud imagery during the night, is best at measuring cloud-top properties. Flossie, however, had a lower-level circulation that was evident in visible imagery earlier in the day. At nighttime that information was lost using traditional satellite technology, such as GOES West. The day-night-band on Suomi NPP provides visible-like information during nighttime hours when only moonlight is available. When Suomi NPP passed over the storm around 1:00am (local), the day-night band imagery allowed forecasters to identify a center of circulation that was more north than previously estimated. Two passes from Suomi NPP (at 11 and 12z, respectively) are shown here. The spiral of the lower level clouds and center of circulation can be seen northwest of Hawaii, whereas the more detailed and higher cloud top areas are due east of the Big Island. Also visible are the nighttime lights of Honolulu on Oahu, along with other cities throughout the island chain. Credit NASA/NOAA An unlabeled version may be downloaded here: 1.usa.gov/1bOjhN6 NASA image use policy. NASA Goddard Space Flight Center enables NASA’s mission through four scientific endeavors: Earth Science, Heliophysics, Solar System Exploration, and Astrophysics. Goddard plays a leading role in NASA’s accomplishments by contributing compelling scientific knowledge to advance the Agency’s mission. Follow us on Twitter Like us on Facebook Find us on Instagram

Emergy evaluation of water utilization benefits in water-ecological-economic system based on water cycle process

NASA Astrophysics Data System (ADS)

Guo, X.; Wu, Z.; Lv, C.

2017-12-01

The water utilization benefits are formed by the material flow, energy flow, information flow and value stream in the whole water cycle process, and reflected along with the material circulation of inner system. But most of traditional water utilization benefits evaluation are based on the macro level, only consider the whole material input and output and energy conversion relation, and lack the characterization of water utilization benefits accompanying with water cycle process from the formation mechanism. In addition, most studies are from the perspective of economics, only pay attention to the whole economic output and sewage treatment economic investment, but neglect the ecological function benefits of water cycle, Therefore, from the perspective of internal material circulation in the whole system, taking water cycle process as the process of material circulation and energy flow, the circulation and flow process of water and other ecological environment, social economic elements were described, and the composition of water utilization positive and negative benefits in water-ecological-economic system was explored, and the performance of each benefit was analyzed. On this basis, the emergy calculation method of each benefit was proposed by emergy quantitative analysis technique, which can realize the unified measurement and evaluation of water utilization benefits in water-ecological-economic system. Then, taking Zhengzhou city as an example, the corresponding benefits of different water cycle links were calculated quantitatively by emergy method, and the results showed that the emergy evaluation method of water utilization benefits can unify the ecosystem and the economic system, achieve uniform quantitative analysis, and measure the true value of natural resources and human economic activities comprehensively.

A nested pre-operational model for the Egyptian shelf zone: Model configuration and validation/calibration

NASA Astrophysics Data System (ADS)

Nagy, H.; Elgindy, A.; Pinardi, N.; Zavatarelli, M.; Oddo, P.

2017-12-01

We explored the variability of the Egyptian shelf zone circulation connected to atmospheric forcing by means of a numerical simulation of the general circulation. A high resolution model grid was used at 1/60° horizontal resolution and 25 sigma layers. The simulation was carried out using the most recent version of the Princeton Ocean Model (POM). The initialised model was run the whole year of 2006 using the analysis forcing data for the same year obtained from ECMWF and MFS (Mediterranean Forecasting System, Pinardi et al., 2003). The model skills were evaluated by means of the root mean square error (RMSE) and correlations. The Egyptian Shelf Model (EGYSHM) simulation suggests the presence of an Egyptian Shelf Slope Current (ESSC), which is flowing eastward at different depths in the domain. We found that the maximum velocity of the ESSC [0.25 m/s] is located near the continental slope during the summer time, while in winter the velocity of ESSC is weaker [0.12 m/s] in the same location. The ESSC appears to be directly affected by Mersa-Matruh gyre system. EGYSHM reproduced the main region circulation patterns, especially after adding the Nile River outflow. We found that wind stress is crucial to force the circulation of the Egyptian shelf zone. EGYSHM SST was significantly correlated to satellite SST in all months at a 95% confidence limit, with a maximum of 0.9743 which was obtained in May 2006. The RMSE between EGYSHM and Argo floats salinity data was about 0.09. We compared our results with satellite altimetry to verify the positions and shapes of mesoscale features.

Bio-objects’ political capacity: a research agenda

PubMed Central

Maeseele, Pieter; Hendrickx, Kim; Pavone, Vincenzo; Van Hoyweghen, Ine

2013-01-01

This article explores the merits of foregrounding the dichotomy of politicization vs de-politicization for our understanding of bio-objects in order to study their production, circulation, and governance in European societies. By asking how bio-objects are configured in science, policy, public, and media discourses and practices, we focus on the role of socio-technical configurations in generating political relations. The bio-object thereby serves as an entry point to approach and conceptualize “the political” in an innovative way. PMID:23630150

From subjects to relations: Bioethics and the articulation of postcolonial politics in the Cambodia Pre-Exposure Prophylaxis trial.

PubMed

Grant, Jenna M

2016-04-01

Controversies about global clinical trials, particularly HIV trials, tend to be framed in terms of ethics. In this article, I explore debates about ethics in the Cambodia Pre-Exposure Prophylaxis trial, which was designed to test the safety and efficacy of tenofovir as a prevention for HIV infection. Bringing together studies of public participation in science with studies of bioethics, I show how activists around the Cambodian Pre-Exposure Prophylaxis trial circulated and provoked debates about standards of research ethics, as opposed to research methodology. This postcolonial bioethics was configured through the circulation of and debate about ethics guidelines, and historically and culturally specific relations of vulnerability and responsibility between foreigners and Cambodians and between Cambodian leaders and Cambodian subjects. I argue that this shift in the object of ethical concern, from the experimental human subject to the relation between subjects and researchers, illustrates how a postcolonial field of articulation reformulates classical bioethics.

Modelling the transport and accumulation of floating marine debris in the Mediterranean basin.

PubMed

Mansui, J; Molcard, A; Ourmières, Y

2015-02-15

In the era of plastic and global environmental issues, when large garbage patches have been observed in the main oceanic basins, this work is the first attempt to explore the possibility that similar permanent accumulation structures may exist in the Mediterranean Sea. The questions addressed in this work are: can the general circulation, with its sub-basins scale gyres and mesoscale instabilities, foster the concentration of floating items in some regions? Where are the more likely coastal zones impacted from open ocean sources? Multi-annual simulations of advected surface passive debris depict the Tyrrhenian Sea, the north-western Mediterranean sub-basin and the Gulf of Sirte as possible retention areas. The western Mediterranean coasts present very low coastal impact, while the coastal strip from Tunisia to Syria appears as the favourite destination. No permanent structure able to retain floating items in the long-term were found, as the basin circulation variability brings sufficient anomalies. Copyright © 2014 Elsevier Ltd. All rights reserved.

FOXO1 orchestrates the bone-suppressing function of gut-derived serotonin

PubMed Central

Kode, Aruna; Mosialou, Ioanna; Silva, Barbara C.; Rached, Marie-Therese; Zhou, Bin; Wang, Ji; Townes, Tim M.; Hen, Rene; DePinho, Ronald A.; Guo, X. Edward; Kousteni, Stavroula

2012-01-01

Serotonin is a critical regulator of bone mass, fulfilling different functions depending on its site of synthesis. Brain-derived serotonin promotes osteoblast proliferation, whereas duodenal-derived serotonin suppresses it. To understand the molecular mechanisms of duodenal-derived serotonin action on osteoblasts, we explored its transcriptional mediation in mice. We found that the transcription factor FOXO1 is a crucial determinant of the effects of duodenum-derived serotonin on bone formation We identified two key FOXO1 complexes in osteoblasts, one with the transcription factor cAMP-responsive element–binding protein 1 (CREB) and another with activating transcription factor 4 (ATF4). Under normal levels of circulating serotonin, the proliferative activity of FOXO1 was promoted by a balance between its interaction with CREB and ATF4. However, high circulating serotonin levels prevented the association of FOXO1 with CREB, resulting in suppressed osteoblast proliferation. These observations identify FOXO1 as the molecular node of an intricate transcriptional machinery that confers the signal of duodenal-derived serotonin to inhibit bone formation. PMID:22945629

Hypothesis: Pentoxifylline explores new horizons in treatment of preeclampsia.

PubMed

Azimi, Arsalan; Ziaee, Seyyed Mohyeddin; Farhadi, Pouya; Sagheb, Mohammad Mahdi

2015-10-01

Preeclampsia, the leading cause of maternal morbidity and perinatal mortality, initiates as inappropriate immune response to trophoblastic invasion impairs placentation and placental circulation. A poorly perfused placenta generates superoxide anions as well as anti-angiogenic factors and this series of events result in impairment of endothelial function, followed by maternal morbidities such as hypertension, kidney injury and proteinuria. Renal loss of anti-coagulant proteins and subsequent hyper-coagulable state along with endothelial dysfunction accelerates progression of the disease toward eclampsia. Since Pentoxifylline, a methyl-xanthine derivative known for enhancement of vascular endothelial function, down-regulation of many inflammatory cytokines increased during preeclampsia, improvement of placental circulation, reduction of ischemia-reperfusion injury, enhancement of vasodilatation and endothelial function, ameliorating proteinuria, inhibition of platelet aggregation and decreasing risk of preterm labor, which are all amongst morbidities of preeclampsia, here it is hypothesized that Pentoxifylline prevents development of preeclampsia and/or decelerate progression of the disease. Copyright © 2015 Elsevier Ltd. All rights reserved.

The relationship between Arctic sea ice and the Atlantic meridional overturning circulation in a warming climate

NASA Astrophysics Data System (ADS)

Liu, W.; Fedorov, A. V.

2017-12-01

A recent study (Sevellec, Fedorov, Liu 2017, Nature Climate Change) has suggested that Arctic sea ice decline can lead to a slow-down of the Atlantic meridional overturning circulation (AMOC). Here, we build on this previous work and explore the relationship between Arctic sea ice and the AMOC in climate models. We find that the current Arctic sea ice decline can contribute about 40% to the AMOC weakening over the next 60 years. This effect is related to the warming and freshening of the upper ocean in the Arctic, and the subsequent spread of generated buoyancy anomalies downstream where they affect the North Atlantic deep convection sites and hence the AMOC on multi-decadal timescales. The weakening of the AMOC and its poleward heat transport, in turn, sustains the "Warming Hole" - a region in the North Atlantic with anomalously weak (or even negative) warming trends. We discuss the key factors that control this robust AMOC response to changes in Arctic sea ice.

Loss of serum IGF-I input to the brain as an early biomarker of disease onset in Alzheimer mice

PubMed Central

Trueba-Sáiz, A; Cavada, C; Fernandez, A M; Leon, T; González, D A; Fortea Ormaechea, J; Lleó, A; Del Ser, T; Nuñez, A; Torres-Aleman, I

2013-01-01

Circulating insulin-like growth factor I (IGF-I) enters the brain and promotes clearance of amyloid peptides known to accumulate in Alzheimer's disease (AD) brains. Both patients and mouse models of AD show decreased level of circulating IGF-I enter the brain as evidenced by a lower ratio of cerebrospinal fluid/plasma IGF-I. Importantly, in presymptomatic AD mice this reduction is already manifested as a decreased brain input of serum IGF-I in response to environmental enrichment. To explore a potential diagnostic use of this early loss of IGF-I input, we monitored electrocorticogram (ECG) responses to systemic IGF-I in mice. Whereas control mice showed enhanced ECG activity after IGF-I, presymptomatic AD mice showed blunted ECG responses. Because nonhuman primates showed identically enhanced electroencephalogram (EEG) activity in response to systemic IGF-I, loss of the EEG signature of serum IGF-I may be exploited as a disease biomarker in AD patients. PMID:24301648

Clinical challenges in the molecular characterization of circulating tumour cells in breast cancer.

PubMed

Lianidou, E S; Mavroudis, D; Georgoulias, V

2013-06-25

Blood testing for circulating tumour cells (CTC) has emerged as one of the hottest fields in cancer research. CTC detection and enumeration can serve as a 'liquid biopsy' and an early marker of response to systemic therapy, whereas their molecular characterisation has a strong potential to be translated to individualised targeted treatments and spare breast cancer (BC) patients unnecessary and ineffective therapies. Different analytical systems for CTC detection and isolation have been developed and new areas of research are directed towards developing novel assays for CTC molecular characterisation. Molecular characterisation of single CTC holds considerable promise for predictive biomarker assessment and to explore CTC heterogeneity. The application of extremely powerful next-generation sequencing technologies in the area of CTC molecular characterisation in combination with reliable single CTC isolation opens new frontiers for the management of patients in the near future. This review is mainly focused on the clinical potential of the molecular characterisation of CTC in BC.

Clinical challenges in the molecular characterization of circulating tumour cells in breast cancer

PubMed Central

Lianidou, E S; Mavroudis, D; Georgoulias, V

2013-01-01

Blood testing for circulating tumour cells (CTC) has emerged as one of the hottest fields in cancer research. CTC detection and enumeration can serve as a ‘liquid biopsy' and an early marker of response to systemic therapy, whereas their molecular characterisation has a strong potential to be translated to individualised targeted treatments and spare breast cancer (BC) patients unnecessary and ineffective therapies. Different analytical systems for CTC detection and isolation have been developed and new areas of research are directed towards developing novel assays for CTC molecular characterisation. Molecular characterisation of single CTC holds considerable promise for predictive biomarker assessment and to explore CTC heterogeneity. The application of extremely powerful next-generation sequencing technologies in the area of CTC molecular characterisation in combination with reliable single CTC isolation opens new frontiers for the management of patients in the near future. This review is mainly focused on the clinical potential of the molecular characterisation of CTC in BC. PMID:23756869

Hydrodynamic patterns favouring sea urchin recruitment in coastal areas: A Mediterranean study case.

PubMed

Farina, S; Quattrocchi, G; Guala, I; Cucco, A

2018-05-11

In invertebrate fisheries, sea urchin harvesting continues to grow with dramatic consequences for benthic ecosystems. The identification of areas with a marked natural recruitment and the mechanisms regulating it is crucial for the conservation of benthic communities and for planning the sustainable harvesting. This study evaluates the spatial distribution and density of recruits of the edible sea urchin Paracentrotus lividus along the Sinis + Peninsula (Sardinia) and explores its significant relationships with the local oceanographic features. Our results reveal that recruitment is favoured in areas with slow currents and high levels of confinement and trapping of the water masses. Analysis of the residual circulation indicates that the presence of local standing circulation structures promotes the sea urchin recruitment process. Our findings emphasize the importance of managing local sea urchin harvesting as a system of populations with their demographic influence mainly dependent on the most important ecological driver that is the recruitment. Copyright © 2018 Elsevier Ltd. All rights reserved.

On the role of ozone feedback in the ENSO amplitude response under global warming.

PubMed

Nowack, Peer J; Braesicke, Peter; Luke Abraham, N; Pyle, John A

2017-04-28

The El Niño-Southern Oscillation (ENSO) in the tropical Pacific Ocean is of key importance to global climate and weather. However, state-of-the-art climate models still disagree on the ENSO's response under climate change. The potential role of atmospheric ozone changes in this context has not been explored before. Here we show that differences between typical model representations of ozone can have a first-order impact on ENSO amplitude projections in climate sensitivity simulations. The vertical temperature gradient of the tropical middle-to-upper troposphere adjusts to ozone changes in the upper troposphere and lower stratosphere, modifying the Walker circulation and consequently tropical Pacific surface temperature gradients. We show that neglecting ozone changes thus results in a significant increase in the number of extreme ENSO events in our model. Climate modeling studies of the ENSO often neglect changes in ozone. We therefore highlight the need to understand better the coupling between ozone, the tropospheric circulation, and climate variability.

Overlap in the Seasonal Infection Patterns of Avian Malaria Parasites and West Nile Virus in Vectors and Hosts

PubMed Central

Medeiros, Matthew C. I.; Ricklefs, Robert E.; Brawn, Jeffrey D.; Ruiz, Marilyn O.; Goldberg, Tony L.; Hamer, Gabriel L.

2016-01-01

Multiple vector-borne pathogens often circulate in the same vector and host communities, and seasonal infection dynamics influence the potential for pathogen interactions. Here, we explore the seasonal infection patterns of avian malaria (Haemosporida) parasites (Plasmodium and Haemoproteus) and West Nile virus (WNV) in birds and mosquitoes in suburban Chicago. We show that both pathogens vary seasonally in Culex mosquitoes and avian hosts, but that patterns of covariation are complex. Different putative Plasmodium species varied asynchronously across the season in mosquitoes and birds, suggesting that different forces may govern their transmission. Infections of Culex mosquitoes with Plasmodium parasites were positively associated with WNV infections in pools of individuals aggregated from the same time and site, suggesting that these pathogens respond to common environmental drivers and co-circulate among the same host and vector populations. Future research should focus on these common drivers, and whether these pathogens interact in vectors and hosts. PMID:27621305

Multifunctional High Drug Loading Nanocarriers for Cancer Drug Delivery

NASA Astrophysics Data System (ADS)

Jin, Erlei

2011-12-01

Most anticancer drugs have poor water-solubility, rapid blood clearance, low tumor-selectivity and severe systemic toxicity to healthy tissues. Thus, polymeric nanocarriers have been widely explored for anticancer drugs to solve these problems. However, polymer nanocarriers developed to date still suffer drawbacks including low drug loading contents, premature drug release, slow cellular internalization, slow intracellular drug release and thereby low therapeutic efficiency in cancer thermotherapy. Accordingly, in this dissertation, functional nanocapsules and nanoparticles including high drug loading liposome-like nanocapsules, high drug loading phospholipid-mimic nanocapsules with fast intracellular drug release, high drug loading charge-reversal nanocapsules, TAT based long blood circulation nanoparticles and charge-reversal nuclear targeted nanoparticles are designed and synthesized. These functional carriers have advantages such as high drug loading contents without premature drug release, fast cellular internalization and intracellular drug release, nuclear targeted delivery and long blood circulation. As a result, all these drug carriers show much higher in vitro and in vivo anti-cancer activities.

Parallel Computation of the Regional Ocean Modeling System (ROMS)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wang, P; Song, Y T; Chao, Y

2005-04-05

The Regional Ocean Modeling System (ROMS) is a regional ocean general circulation modeling system solving the free surface, hydrostatic, primitive equations over varying topography. It is free software distributed world-wide for studying both complex coastal ocean problems and the basin-to-global scale ocean circulation. The original ROMS code could only be run on shared-memory systems. With the increasing need to simulate larger model domains with finer resolutions and on a variety of computer platforms, there is a need in the ocean-modeling community to have a ROMS code that can be run on any parallel computer ranging from 10 to hundreds ofmore » processors. Recently, we have explored parallelization for ROMS using the MPI programming model. In this paper, an efficient parallelization strategy for such a large-scale scientific software package, based on an existing shared-memory computing model, is presented. In addition, scientific applications and data-performance issues on a couple of SGI systems, including Columbia, the world's third-fastest supercomputer, are discussed.« less

Can Arctic sea-ice melt be explained by atmospheric meridional transports? (Invited)

NASA Astrophysics Data System (ADS)

Tjernstrom, M. K.; Graversen, R. G.

2010-12-01

The Arctic summer sea ice is melting away at an alarming rate, and it is now expected that an principally sea-ice free Arctic summer will occur much earlier than projected by the IPCC AR4 models. At the same time Arctic near-surface temperatures are rising at a rate much faster than the global average. The processes responsible for these changes are debated and many claim that local feedbacks, such as the surface albedo feedback, are the main culprits while other argue that remote effects, such as atmospheric circulation changes on synoptic and hemispheric scales, are the most important. We will explore the effects of the meridional transport by synoptic and larger scale atmospheric circulation on recent changes, using reanalysis data. It will be illustarated how this transport can contribute significant amounts of sensible heat, but also of atmospheric moisture such that local cloud feedbacks as well as the direct greenhouse effect of the water vapor contributes significantly to the surface energy balance over the Arctic polar cap.

Approximate Stokes Drift Profiles and their use in Ocean Modelling

NASA Astrophysics Data System (ADS)

Breivik, O.; Biblot, J.; Janssen, P. A. E. M.

2016-02-01

Deep-water approximations to the Stokes drift velocity profile are explored as alternatives to the monochromatic profile. The alternative profiles investigated rely on the same two quantities required for the monochromatic profile, viz the Stokes transport and the surface Stokes drift velocity. Comparisons with parametric spectra and profiles under wave spectra from the ERA-Interim reanalysis and buoy observations reveal much better agreement than the monochromatic profile even for complex sea states. That the profiles give a closer match and a more correct shear has implications for ocean circulation models since the Coriolis-Stokes force depends on the magnitude and direction of the Stokes drift profile and Langmuir turbulence parameterizations depend sensitively on the shear of the profile. The NEMO general circulation ocean model was recently extended to incorporate the Stokes-Coriolis force along with two other wave-related effects. I will show some results from the coupled atmosphere-wave-ocean ensemble forecast system of ECMWF where these wave effects are now included in the ocean model component.

Evidence of Tropospheric 90 Day Oscillations in the Thermosphere

NASA Astrophysics Data System (ADS)

Gasperini, F.; Hagan, M. E.; Zhao, Y.

2017-10-01

In the last decade evidence demonstrated that terrestrial weather greatly impacts the dynamics and mean state of the thermosphere via small-scale gravity waves and global-scale solar tidal propagation and dissipation effects. While observations have shown significant intraseasonal variability in the upper mesospheric mean winds, relatively little is known about this variability at satellite altitudes (˜250-400 km). Using cross-track wind measurements from the Challenging Minisatellite Payload and Gravity field and steady-state Ocean Circulation Explorer satellites, winds from a Modern-Era Retrospective Analysis for Research and Applications/Thermosphere-Ionosphere-Mesosphere-Electrodynamics General Circulation Model simulation, and outgoing longwave radiation data, we demonstrate the existence of a prominent and global-scale 90 day oscillation in the thermospheric zonal mean winds and in the diurnal eastward propagating tide with zonal wave number 3 (DE3) during 2009-2010 and present evidence of its connection to variability in tropospheric convective activity. This study suggests that strong coupling between the troposphere and the thermosphere occurs on intraseasonal timescales.

Investigation of Oxytocin Secretion in Anorexia Nervosa and Bulimia Nervosa: Relationships to Temperament Personality Dimensions.

PubMed

Monteleone, Alessio Maria; Scognamiglio, Pasquale; Volpe, Umberto; Di Maso, Virginia; Monteleone, Palmiero

2016-01-01

Published studies suggested an implication of oxytocin in some temperament characteristics of personality. Therefore, we measured oxytocin secretion in 23 women with anorexia nervosa (AN), 27 with bulimia nervosa (BN) and 19 healthy controls and explored the relationships between circulating oxytocin and patients' personality traits. Plasma oxytocin levels were significantly reduced in AN women but not in BN ones. In healthy women, the attachment subscale scores of the reward dependence temperament and the harm avoidance (HA) scores explained 82% of the variability in circulating oxytocin. In BN patients, plasma oxytocin resulted to be negatively correlated with HA, whereas no significant correlations emerged in AN patients. These findings confirm a dysregulation of oxytocin production in AN but not in BN and show, for the first time, a disruption of the associations between hormone levels and patients' temperament traits, which may have a role in certain deranged behaviours of eating disorder patients. Copyright © 2015 John Wiley & Sons, Ltd and Eating Disorders Association.

The long postwar and the politics of penicillin: early circulation and smuggling in Spain, 1944-1954.

PubMed

Santesmases, María Jesús

2014-01-01

In this paper I explore the early circulation of penicillin. I review the early distribution in Spain of a scarce product, reflect on the available sources about the illegal penicillin trade and discuss some cases of smuggling. I argue the early distribution of penicillin involved time and geography, a particular chronology of post Second World War geopolitics. Penicillin practices and experiences belong to this period, in a dictatorship that tolerated smuggling and illegal trade of other products, some, like penicillin, produced in neighbouring countries. As a commodity that crossed borders, penicillin, transiting between the law and hidden trade, between countries and social domains--between war fronts and from a war front to an urban site to be sold--reveals practices of the early years of prosperity in the 1950s. These transits were permanent tests of a society based on taxes and exchanges, law and bureaucracy, control, discipline and the creation of standards.

Impacts of tropical deforestation. Part II: The role of large-scale dynamics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhang, H.; Henderson-Sellers, A.; McGuffie, K.

1996-10-01

This is the second in a pair of papers in which the possible impacts of tropical deforestation are examined using a version of the NCAR CCM1. The emphasis in this paper is on the influence of tropical deforestation on the large-scale climate system. This influence is explored through the examination of the regional moisture budget and through an analysis of the Hadley and Walker circulations. Modification of the model surface parameters to simulate tropical deforestation produces significant modifications of both Hadley and Walker circulations, which result in changes distant from the region of deforestation. A mechanism for propagation to middlemore » and high latitudes of disturbances arising form tropical deforestation is proposed based on Rossby wave propagation mechanisms. These mechanisms, which have also been associated with the extratropical influences of ENSO events, provide a pathway for the dispersion of the tropical disturbances to high latitudes. 27 refs., 20 figs., 1 tab.« less

Circulation in the Ecologically Protected Lau Basin

NASA Astrophysics Data System (ADS)

Simons, E.; Speer, K. G.; Weijer, W.

2016-12-01

The Lau Basin, located in the South Pacific, north of New Zealand and East of Fiji, is a back-arc basin with active hydrothermal vents and volcanoes. In September 2015, the New Zealand Ministry for the Environment announced the new Kermadec Ocean Sanctuary in the southern portion of the basin. The sanctuary, which covers more than 620,000 square kilometers, is the world's largest protected marine environment boasting endangered species from turtles, whales, and seabirds to corals, shellfish, and zooplankton. Though protections are in place for the ecological residents of the basin, little is known about the fluid circulation that permits such ecological diversity. Whitworth et al. (1999), explored the water-masses associated with the deep western boundary current (DWBC) in the Tonga-Kermadec Trench and found the trench to be a passageway for Circumpolar Deep Water (CDW) into the South Pacific. In this project, an analysis of Ridge 2000 Program floats and Argo floats show intrusion of water from the trench into the basin, potentially providing another pathway of CDW into the western edge of the South Pacific. Using a simple model developed by Stommel-Arons (1960) and expanded upon by Pedlosky (1989) for abyssal circulation, the bulk of the flow pattern observed from the floats is qualitatively described, including the well-defined DWBC, first observed in this data, along the Lau-Fiji ridge.

Heat dissipation by blood circulation and airway tissue heat absorption in a canine model of inhalational thermal injury.

PubMed

Wan, Jiangbo; Zhang, Guoan; Qiu, Yuxuan; Wen, Chunquan; Fu, Tairan

2016-05-01

This study aimed to further explore heat dissipation by blood circulation and airway tissue heat absorption in an inhalational thermal injury model. Twelve adult male Beagle dogs were divided into four groups to inhale heated air for 10min: the control group, group I (100.5°C), group II (161.5°C), and group III (218°C). The relative humidity and temperature of the inhaled heated air were measured in the heating tube and trachea, as were blood temperatures and flow velocities in both common jugular veins. Formulas were used to calculate the total heat quantity reduction of the heated air, heat dissipation by the blood, and airway tissue heat absorption. The blood temperatures of both the common jugular veins increased by 0.29°C±0.07°C to 2.96°C±0.24°C and the mean blood flow volume after injury induction was about 1.30-1.74 times greater than before injury induction. The proportions of heat dissipated by the blood and airway tissue heat absorption were 68.92%±14.88% and 31.13%±14.87%, respectively. The heat dissipating ability of the blood circulation was demonstrated and improved upon along with tissue heat absorption owing to increased regional blood flow. Copyright © 2015 Elsevier Ltd and ISBI. All rights reserved.

Mobile Bay river plume mixing in the inner shelf

NASA Astrophysics Data System (ADS)

Parra, S. M.; Book, J. W.; Warner, S. J.; Moum, J.

2017-12-01

The microtidal region (0.5 m spring tides) of the inner shelf outside Mobile Bay presented a complex circulation pattern driven by the pulsed river discharge and winds. Currents, salinity, temperature, and turbulence profiles were measured for up to three weeks in April 2016 at six moorings outside Mobile Bay. Currents varied between locations and with depth. During neap and spring tides the currents were reliably >0.4 and <0.4 m/s, respectively. The outflow from Mobile Bay generated a complex density circulation, where two to three layers were normally present. Multiple density layers included a thicker brackish middle layer (5-10 m thickness), and a salty bottom layer (5-10 m thickness), with a thin ( 1-3 m) freshwater surface layer found intermittently. The multilayer currents were strongest at neap tides (>0.5 m/s) and toward deeper waters, concurrent with the strongest stratification. The possible flow drivers considered include tides, winds, inertial oscillations, waves, and stratification. Turbulent kinetic energy production and dissipation were calculated with multiple methods using data from bottom-mounted, upward-looking acoustic Doppler current profilers sampling at 1 Hz, and using data from line-moored chi-pod turbulent temperature microstructure instruments sampling at 100 Hz. This work explores different forcing mechanisms involved in modulating the circulation and turbulence in a multi-layered pulsed-river inner shelf region in the Gulf of Mexico.

Weak overturning circulation and increased iron fertilization maximized carbon storage in the glacial ocean

NASA Astrophysics Data System (ADS)

Muglia, J.; Skinner, L.; Schmittner, A.

2017-12-01

Circulation changes have been suggested to play an important role in the sequestration of atmospheric CO2 in the glacial ocean. However, previous studies have resulted in contradictory results regarding the strength of the Atlantic Meridional Overturning Circulation (AMOC) and three-dimensional, quantitative reconstructions of the glacial ocean constrained by multiple proxies remain lacking. Here we simulate the modern and glacial ocean using a coupled, global, three-dimensional, physical-biogeochemical model constrained simultaneously by d13C, radiocarbon, and d15N to explore the effects of AMOC differences and Southern Ocean iron fertilization on the distributions of these isotopes and ocean carbon storage. We show that d13C and radiocarbon data sparsely sampled at the locations of existing glacial sediment cores can be used to reconstruct the modern AMOC accurately. Applying this method to the glacial ocean we find that a surprisingly weak (6-9 Sv or about half of today's) and shallow AMOC maximizes carbon storage and best reproduces the sediment data. Increasing the atmospheric soluble iron flux in the model's Southern Ocean intensifies export production, carbon storage, and improves agreement with d13C and d15N reconstructions. Our best fitting model is a significant improvement compared with previous studies. It suggests that a weak and shallow AMOC and enhanced iron fertilization conspired to maximize carbon storage in the glacial ocean.

Prognostic value of insulin-like growth factor 1 and insulin-like growth factor binding protein 3 blood levels in breast cancer.

PubMed

Hartog, H; Boezen, H M; de Jong, M M; Schaapveld, M; Wesseling, J; van der Graaf, W T A

2013-12-01

High circulating insulin-like growth factor 1 (IGF-1) levels are firmly established as a risk factor for developing breast cancer, especially estrogen positive tumors. The effect of circulating IGF-1 on prognosis once a tumor is established is unknown. The authors explored the effect of IGF-1 blood levels and of it's main binding protein, IGFBP-3, on overall survival and occurrence of second primary breast tumors in breast cancer patients, as well as reproductive and lifestyle factors that could modify this risk. Patients were accrued from six hospitals in the Netherlands between 1998 and 2003. Total IGF-1 and IGFBP-3 were measured in 582 plasma samples. No significant association between IGF-1 and IGFBP-3 plasma levels and overall survival was found. However, in a multivariate Cox regression model including standard prognostic variables high IGF-1 levels were related to worse overall survival in patients receiving endocrine therapy (HR = 1.37, 95% CI: 1.11, 1.69, P 0.004). These data at least indicate that higher IGF-1 levels, and as a consequence most likely IGF-1-induced signaling, are related to a less favorable overall survival in breast cancer patients treated with endocrine therapy. Interventions aimed at reducing circulating levels of IGF-1 in hormone receptor positive breast cancer may improve survival. Copyright © 2013 Elsevier Ltd. All rights reserved.

Evolution and phylogeographic dissemination of endemic porcine picornaviruses in Vietnam

PubMed Central

Lu, Lu; Van Dung, Nguyen; Bryant, Juliet E.; Carrique-Mas, Juan; Van Cuong, Nguyen; Anh, Pham Honh; Rabaa, Maia A.; Baker, Stephen; Simmonds, Peter; Woolhouse, Mark E.

2016-01-01

Members of the Picornaviridae are important and often zoonotic viruses responsible for a variety of human and animal diseases. However, the evolution and spatial dissemination of different picornaviruses circulating in domestic animals are not well studied. We examined the rate of evolution and time of origin of porcine enterovirus G (EV-G) and porcine kobuvirus species C lineages (PKV-C) circulating in pig farms in Vietnam and from other countries. We further explored the spatiotemporal spread of EV-G and PKV-C in Southwest Vietnam using phylogeographic models. Multiple types of EV-G are co-circulating in Vietnam. The two dominant EV-G types among isolates from Vietnam (G1 and G6) showed strong phylogenetic clustering. Three clades of PKV-C (PKV-C1-3) represent more recent introductions into Vietnam; PKV-C2 is closely related to PKV-C from Southwest China, indicating possible cross-border dissemination. In addition, high virus lineage migration rates were estimated within four districts in Dong Thap province in Vietnam for both EV-G types (G1, G6) and all PKV-C (C1-3) clades. We found that Chau Thanh district is a primary source of both EV-G and PKV-C clades, consistent with extensive pig trading in and out of the district. Understanding the evolution and spatial dissemination of endemic picornaviruses in pigs may inform future strategies for the surveillance and control of picornaviruses. PMID:27774295

HIV-1/HAART-Related Lipodystrophy Syndrome (HALS) Is Associated with Decreased Circulating sTWEAK Levels

PubMed Central

López-Dupla, Miguel; Maymó-Masip, Elsa; Martínez, Esteban; Domingo, Pere; Leal, Manuel; Peraire, Joaquim; Viladés, Consuelo; Veloso, Sergi; Arnedo, Mireia; Ferrando-Martínez, Sara; Beltrán-Debón, Raúl; Alba, Verónica; Gatell, Josep Mª; Vendrell, Joan; Vidal, Francesc; Chacón, Matilde R.

2015-01-01

Background and Objectives Obesity and HIV-1/HAART–associated lipodystrophy syndrome (HALS) share clinical, pathological and mechanistic features. Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) is a multifunctional cytokine that plays an important role in obesity and related diseases. We sought to explore the relationship between HALS and circulating levels of soluble (s) TWEAK and its scavenger receptor sCD163. Methods This was a cross-sectional multicenter study of 120 HIV-1-infected patients treated with a stable HAART regimen; 56 with overt HALS and 64 without HALS. Epidemiological and clinical variables were determined. Serum levels of sTWEAK and sCD163 levels were measured by ELISA. Results were analyzed with Student’s t-test, Mann-Whitney U and χ2 test. Pearson and Spearman correlation were used to estimate the strength of association between variables. Results Circulating sTWEAK was significantly decreased in HALS patients compared with non-HALS patients (2.81±0.2 vs. 2.94±0.28 pg/mL, p = 0.018). No changes were observed in sCD163 levels in the studied cohorts. On multivariate analysis, a lower log sTWEAK concentration was independently associated with the presence of HALS (OR 0.027, 95% CI 0.001–0.521, p = 0.027). Conclusions HALS is associated with decreased sTWEAK levels. PMID:26658801

Antiplatelet Usage Impacts Clot Density in Acute Anterior Circulation Ischemic Stroke

PubMed Central

Pikija, Slaven; Magdic, Jozef; Lukic, Anita; Schreiber, Catharina; Mutzenbach, Johannes Sebastian; McCoy, Mark R.; Sellner, Johann

2016-01-01

We explored whether clot density in middle cerebral artery (MCA) occlusion is related to clinical variables, stroke etiology, blood constituents, and prestroke medication. We performed a retrospective chart review of patients with acute ischemic stroke of the anterior circulation admitted to two Central European stroke centers. The acquisition of non-contrast enhanced CT (NECT) and CT angiography (CTA) within 4.5 h of symptom onset was obligatory. We assessed the site of MCA occlusion as well as density, area, and length of the clot in 150 patients. The Hounsfield unit values for the clot were divided with contralateral MCA segment to yield relative Hounsfield Unit ratio (rHU). The site of the vessel occlusion (M1 vs. M2) and antiplatelet usage, but not stroke etiology, significantly influenced rHU. We found an inverse correlation of rHU with erythrocyte count (p < 0.001). The multivariate analysis revealed that a higher rHU (i.e., clot being more hyperdense) was more likely with the use of antiplatelets (OR 4.24, CI 1.10–16.31, p = 0.036). Erythrocyte (OR 0.18, CI 0.05–0.55, p = 0.003), and thrombocyte counts (OR 0.99, CI 0.98–0.99, p = 0.029) were associated with odds for more hypodense clots (lower rHU). Our study disclosed that antiplatelet therapy impacts the composition of intracranial clots of the anterior circulation. PMID:27563874

A drop in uniaxial and biaxial nonlinear extensional flows

NASA Astrophysics Data System (ADS)

Favelukis, M.

2017-08-01

In this theoretical report, we explore small deformations of an initially spherical drop subjected to uniaxial or biaxial nonlinear extensional creeping flows. The problem is governed by the capillary number (Ca), the viscosity ratio (λ), and the nonlinear intensity of the flow (E). When the extensional flow is linear (E = 0), the familiar internal circulations are obtained and the same is true with E > 0, except that the external and internal flow rates increase with increasing E. If E < 0, the external flow consists of some unconnected regions leading to the same number of internal circulations (-3/7 < E < 0) or twice the number of internal circulations (E < -3/7), when compared to the linear case. The shape of the deformed drop is represented in terms of a modified Taylor deformation parameter, and the conditions for the breakup of the drop by a center pinching mechanism are also established. When the flow is linear (E = 0), the literature predicts prolate spheroidal drops for uniaxial flows (Ca > 0) and oblate spheroidal drops for biaxial flows (Ca < 0). For the same |Ca|, if E > 0, the drop is more elongated than the linear case, while E < 0 results in less elongated drops than the linear case. Compared to the linear case, for both uniaxial and biaxial extensional flows, E > 0 tends to facilitate drop breakup, while E < 0 makes drop breakup more difficult.

On Temporal Patterns and Circulation of Influenza Virus Strains in Taiwan, 2008-2014: Implications of 2009 pH1N1 Pandemic.

PubMed

Hsieh, Ying-Hen; Huang, Hsiang-Min; Lan, Yu-Ching

2016-01-01

It has been observed that, historically, strains of pandemic influenza led to succeeding seasonal waves, albeit with decidedly different patterns. Recent studies suggest that the 2009 A(H1N1)pdm09 pandemic has had an impact on the circulation patterns of seasonal influenza strains in the post-pandemic years. In this work we aim to investigate this issue and also to compare the relative transmissibility of these waves of differing strains using Taiwan influenza surveillance data before, during and after the pandemic. We make use of the Taiwan Center for Disease Control and Prevention influenza surveillance data on laboratory-confirmed subtyping of samples and a mathematical model to determine the waves of circulating (and co-circulating) H1, H3 and B virus strains in Taiwan during 2008-2014; or namely, short before, during and after the 2009 pandemic. We further pinpoint the turning points and relative transmissibility of each wave, in order to ascertain whether any temporal pattern exists. For two consecutive years following the 2009 pandemic, A(H1N1)pdm09 circulated in Taiwan (as in most of Northern Hemisphere), sometimes co-circulating with AH3. From the evolution point of view, A(H1N1)pdm09 and AH3 were able to sustain their circulation patterns to the end of 2010. In fact, A(H1N1)pdm09 virus circulated in six separate waves in Taiwan between summer of 2009 and spring of 2014. Since 2009, a wave of A(H1N1)pmd09 occurred every fall/winter influenza season during our study period except 2011-2012 season, when mainly influenza strain B circulated. In comparing transmissibility, while the estimated per capita weekly growth rates for cumulative case numbers (and the reproduction number) seem to be lower for most of the influenza B waves (0.06~0.26; range of 95% CIs: 0.05~0.32) when compared to those of influenza A, the wave of influenza B from week 8 to week 38 of 2010 immediately following the fall/winter wave of 2009 A(H1N1) pdm09 was substantially higher at r = 0.89 (95% CI: 0.49, 1.28), in fact highest among all the waves detected in this study. Moreover, when AH3 or A(H1N1)pdm09 exhibit high incidence, reported cases of subtype B decreases and vice versa. Further modeling analysis indicated that during the study period, Taiwan nearly experienced at least one wave of influenza epidemic of some strain every summer except in 2012. Estimates of R for seasonal influenza are consistent with that of temperate and tropical-subtropical regions, while estimate of R for A(H1N1)pdm09 is comparatively less than countries in Europe and North America, but similar to that of tropical-subtropical regions. This offers indication of regional differences in transmissibility of influenza virus that exists only for pandemic influenza. Despite obvious limitations in the data used, this study, designed to qualitatively compare the temporal patterns and transmissibility of the waves of different strains, illustrates how influenza subtyping data can be utilized to explore the mechanism for various influenza strains to compete or to circulate, to possibly provide predictors of future trends in the evolution of influenza viruses of various subtypes, and perhaps more importantly, to be of use to future annual seasonal influenza vaccine design.

Neutral winds in the polar thermosphere as measured from Dynamics Explorer

NASA Technical Reports Server (NTRS)

Killeen, T. L.; Hays, P. B.; Spencer, N. W.; Wharton, L. E.

1982-01-01

Remote sensing measurements of the meridional thermospheric neutral wind using the Fabry-Perot Interferometer on Dynamics Explorer have been combined with in-situ measurements of the zonal component using the Wind and Temperature Spectrometer on the same spacecraft. The two data sets with appropriate spatial phasing and averaging determine the vector wind along the track of the polar orbiting spacecraft. A study of fifty-eight passes over the Southern (sunlit) pole has enabled the average Universal Time dependence of the wind field to be determined for essentially a single solar local time cut. The results show the presence of a 'back-ground' wind field driven by solar EUV heating upon which is superposed a circulating wind field driven by high latitude momentum and energy sources.

Coupled climate impacts of the Drake Passage and the Panama Seaway

NASA Astrophysics Data System (ADS)

Yang, Simon; Galbraith, Eric; Palter, Jaime

2014-07-01

Tectonically-active gateways between ocean basins have modified ocean circulation over Earth history. Today, the Atlantic and Pacific are directly connected via the Drake Passage, which forms a barrier to the time-mean geostrophic transport between the subtropics and Antarctica. In contrast, during the warm early Cenozoic era, when Antarctica was ice-free, the Drake Passage was closed. Instead, at that time, the separation of North and South America provided a tropical seaway between the Atlantic and Pacific that remained open until the Isthmus of Panama formed in the relatively recent geological past. Ocean circulation models have previously been used to explore the individual impacts of the Drake Passage and the Panama Seaway, but rarely have the two gateways been considered together, and most explorations have used very simple atmospheric models. Here we use a coupled ocean-ice-atmosphere model (GFDL's CM2Mc), to simulate the impacts of a closed Drake Passage both with and without a Panama Seaway. We find that the climate response to a closed Drake Passage is relatively small when the Panama Seaway is absent, similar to prior studies, although the coupling to a dynamical atmosphere does increase the temperature change. However, with a Panama Seaway, closing Drake Passage has a much larger effect, due to the cessation of deep water formation in the northern hemisphere. Both gateways alter the transport of salt by ocean circulation, with the Panama Seaway allowing fresh Pacific water to be imported to the North Atlantic, and the Drake Passage preventing the flow of saline subtropical water to the circum-Antarctic, a flow that is particularly strong when the Panama Seaway is open. Thus, with a Panama Seaway and a closed Drake Passage, the Southern Ocean tends to be relatively salty, while the North Atlantic tends to be relatively fresh, such that the deep ocean is ventilated from the circum-Antarctic. Ensuing changes in the ocean heat transport drive a bi-polar shift of surface ocean temperatures, and the Intertropical Convergence Zone migrates toward the warmer southern hemisphere. The response of clouds to changes in surface ocean temperatures amplifies the climate response, resulting in temperature changes of up to 9 °C over Antarctica, even in the absence of land-ice feedbacks. These results emphasize the importance of tectonic gateways to the climate history of the Cenozoic, and support a role for ocean circulation changes in the glaciation of Antarctica.

pH-activatable nanoparticles for tumor-specific drug delivery

NASA Astrophysics Data System (ADS)

Liu, Karen C.

To address the need for a tumor-specific drug delivery system that can achieve both prolonged circulation and cellular retention at the tumor site, nanocomplexes of Zwitterionic Chitosan (ZWC) and Polyamidoamine (PAMAM) generation 5 were designed. Polyamidoamine (PAMAM) dendrimers have been widely explored as carriers of therapeutics and imaging agents, however, amine-terminated PAMAM dendrimers are rarely utilized in systemic applications due to its cytotoxicity and risk of opsonization, caused by its cationic charge. Such undesirable effects may be mitigated by shielding the PAMAM dendrimer surface with polymers that reduce the charges. However, this shielding may also interfere with PAMAM dendrimers' ability to interact with target cells, thus reducing cellular uptake and overall efficacy of the delivery system. ZWC, a new chitosan derivative, has a unique pH-sensitive charge profile and can shield the cationic surface of PAMAM dendrimers and block adsorption of serum proteins to allow for prolonged circulation. The hypothesis of this approach is that ZWC is anionic and able to coat PAMAM in neutral pH but becomes positive in the acidic tumor microenvironment, revealing the polycationic drug carrier. We expect that ZWC will provide (i) stealth coating for PAMAM drug carrier during circulation (pH 7.4) and (ii) be removed from the PAMAM drug carrier at acidic pH (pH ~6.3), allowing for cellular interaction. The cationic charge of PAMAM has been demonstrated to facilitate uptake and drug delivery to tumor cells via interactions with the negatively charged cell surface. Stable electrostatic complexes of ZWC and PAMAM dendrimers were formed at pH 7.4, as demonstrated by fluorescence spectroscopy and transmission electron microscopy. The presence of ZWC coating protected red blood cells and fibroblast cells from hemolytic and cytotoxic activities of PAMAM dendrimers, respectively. Confocal microscopy showed that the protective effect of ZWC disappeared at low pH as the complex dissociated due to the charge conversion of ZWC, allowing PAMAM dendrimers to enter cells. These results demonstrate that ZWC is able to provide a surface coverage of PAMAM dendrimers in a pH-dependent manner and, thus, enhance the utility of PAMAM dendrimers as a drug carrier to solid tumors with acidifying microenvironment. Paclitaxel, curcumin, and camptothecin were evaluated as model drugs for use in ZWC(PAMAM) drug carrier based on bioactivity against SKOV-3 ovarian cancer cells and drug loading and release. Stability of nanocarriers in circulation is a requirement for successful tumor-specific drug release. Strategies to improve the stability of ZWC(PAMAM) NPs were also explored and evaluated.

Histological Stratification of Thick and Thin Plaque Psoriasis Explores Molecular Phenotypes with Clinical Implications

PubMed Central

Kim, Dong Joo; Brodmerkel, Carrie; Correa da Rosa, Joel; Krueger, James G.; Suárez-Fariñas, Mayte

2015-01-01

Psoriasis, which presents as red, scaly patches on the body, is a common, autoimmune skin disease that affects 2 to 3 percent of the world population. To leverage recent molecular findings into the personalized treatment of psoriasis, we need a strategy that integrates clinical stratification with molecular phenotyping. In this study, we sought to stratify psoriasis patients by histological measurements of epidermal thickness, and to compare their molecular characterizations by gene expression, serum cytokines, and response to biologics. We obtained histological measures of epidermal thickness in a cohort of 609 psoriasis patients, and identified a mixture of two subpopulations—thick and thin plaque psoriasis—from which they were derived. This stratification was verified in a subcohort of 65 patients from a previously published study with significant differences in inflammatory cell infiltrates in the psoriatic skin. Thick and thin plaque psoriasis shared 84.8% of the meta-analysis-derived psoriasis transcriptome, but a stronger dysregulation of the meta-analysis-derived psoriasis transcriptome was seen in thick plaque psoriasis on microarray. RT-PCR revealed that gene expression in thick and thin plaque psoriasis was different not only within psoriatic lesional skin but also in peripheral non-lesional skin. Additionally, differences in circulating cytokines and their changes in response to biologic treatments were found between the two subgroups. All together, we were able to integrate histological stratification with molecular phenotyping as a way of exploring clinical phenotypes with different expression levels of the psoriasis transcriptome and circulating cytokines. PMID:26176783

Study of hydrothermal channels based on near-bottom magnetic prospecting: Application to Longqi hydrothermal area

NASA Astrophysics Data System (ADS)

Tao, W.; Tao, C.; Li, H.; Zhaocai, W.; Jinhui, Z.; Qinzhu, C.; Shili, L.

2014-12-01

Mid-ocean ridges, largely present far from the continental plates, are characterized by complex geological structures and numerous hydrothermal systems with complex controlling factors. Exploring seafloor sulfide resources for industrial and scientific applications is a challenge. With the advent of geophysical surveys for seabed investigation, near-bottom magnetic prospecting, which yields shallow geological structure, is an efficient method for investigating active and inactive hydrothermal fields and for researching the structure of hydrothermal systems (Tivey et al., 1993, 1996；German et al., 2008). We collected near-bottom magnetic data in the Longqi hydrothermal area, located in the southwest Indian ridge (49.6° E; Zhu et al., 2010; Tao et al., 2014), using the autonomous benthic explorer, an autonomous underwater vehicle, during the second leg of the Chinese cruise DY115-19 on board R/V DaYangYiHao. Based on the results of the intensity of the spatial differential vector method (Seaman et al., 1993), we outline the hydrothermal alternation zone. By building models, we subsequently infer a fault along the discovered hydrothermal vents; this fault line may be connected to a detachment fault (Zhao et al., 2013). In addition, we discuss the channels of the hydrothermal circulation system (Figure 1), and presume that heat was conducted to the sea subsurface by the detachment fault; the aqueous fluid that infiltrated the fault is heated and conveyed to the seafloor, promoting the circulation of the hydrothermal system.

Factors Contributing to Extremely Wet Winters in California

NASA Astrophysics Data System (ADS)

Jong, B. T.; Ting, M.; Seager, R.

2015-12-01

As California continues to battle the severe drought conditions, it becomes increasingly important to understand the atmospheric and oceanic conditions that may possible break this ongoing drought. Is a strong El Niño, such as the 2015/16 event, enough to break the drought? We examine in this study the possible factors that lead to extremely wet winters (the wettest 15%) in both Northern and Southern CA. The relationships between CA winter precipitation and sea surface temperature conditions in the Pacific, as well as atmospheric circulation are determined by using observational and reanalysis data from 1901 to 2010. One of the key features of the atmospheric circulation is the location of the low pressure anomaly, whether caused by El Niño or other factors. If the anomaly locates right off the US west coast, CA tends to be wet, and vice versa. Furthermore, the duration of the circulation anomaly seems to be crucial. During wet El Niño winters, the peak of the circulation anomaly is in the late winter, whereas, during non-wet El Niño winters, the peak of the anomaly is in the early winter. Thus, an El Niño that can last to late winter is more likely to cause an extremely wet winter in the state. The intensity of El Niño is another critical factor. In the wettest tercile late winter, a strong El Niño can bring about 200% of climatological precipitation to CA, while a weak El Niño can bring only less than 150% of climatology. In combination, only a strong El Niño that can last to late winter may make extremely wet winters very likely in CA. To explore the other factors, composites of circulation anomaly during wet & non-El Niño winters were also analyzed. The results show that a zonally propagating wave train, originating from western North Pacific, contributes to low pressure center and wet winter conditions in the state. Thus, coastal low pressure anomaly is a consistent feature for an extremely wet winters in California, but the origin of forcing can come from both tropics and mid-latitude.

Is Polar Amplification Deeper and Stronger than Dynamicists Assume?

NASA Astrophysics Data System (ADS)

Scheff, J.; Maroon, E.

2017-12-01

In the CMIP multi-model mean under strong future warming, Arctic amplification is confined to the lower troposphere, so that the meridional gradient of warming reverses around 500 mb and the upper troposphere is characterized by strong "tropical amplification" in which warming weakens with increasing latitude. This model-derived pattern of warming maxima in the upper-level tropics and lower-level Arctic has become a canonical assumption driving theories of the large-scale circulation response to climate change. Yet, several lines of evidence and reasoning suggest that Arctic amplification may in fact extend through the entire depth of the troposphere, and/or may be stronger than commonly modeled. These include satellite Microwave Sounding Unit (MSU) temperature trends as a function of latitude and vertical level, the recent discovery that the extratropical negative cloud phase feedback in models is largely spurious, and the very strong polar amplification observed in past warm and lukewarm climates. Such a warming pattern, with deep, dominant Arctic amplification, would have very different implications for the circulation than a canonical CMIP-like warming: instead of slightly shifting poleward and strengthening, eddies, jets and cells might shift equatorward and considerably weaken. Indeed, surface winds have been mysteriously weakening ("stilling") at almost all stations over the last half-century or so, there has been no poleward shift in northern hemisphere circulation metrics, and past warm climates' subtropics were apparently quite wet (and their global ocean circulations were weak.) To explore these possibilities more deeply, we examine the y-z structure of warming and circulation changes across a much broader range of models, scenarios and time periods than the CMIP future mean, and use an MSU simulator to compare them to the satellite warming record. Specifically, we examine whether the use of historical (rather than future) forcing, AMIP (rather than CMIP) configuration, individual GCMs, and/or individual ensemble members can better reproduce the structure of the MSU and surface-wind observations. Figure 1 already shows that tropical amplification is absent in the CESM1 historical ensemble (1979-2012). The results of these analyses will guide our future modeling work on these topics.

The Asian monsoon's role in atmospheric heat transport responses to orbital and millennial-scale climate change

NASA Astrophysics Data System (ADS)

McGee, D.; Green, B.; Donohoe, A.; Marshall, J.

2015-12-01

Recent studies have provided a framework for understanding the zonal-mean position of the tropical rain belt by documenting relationships between rain belt latitude and atmospheric heat transport across the equator (Donohoe et al., 2013). Modern seasonal and interannual variability in globally-averaged rain belt position (often referred to as 'ITCZ position') reflects the interhemispheric heat balance, with the rain belt's displacement toward the warmer hemisphere directly proportional to atmospheric heat transport into the cooler hemisphere. Model simulations suggest that rain belt shifts are likely to have obeyed the same relationship with interhemispheric heat transport in response to past changes in orbital parameters, ice sheets, and ocean circulation. This relationship implies that even small (±1 degree) shifts in the mean rain belt require large changes in hemispheric heat budgets, placing tight bounds on mean rain belt shifts in past climates. This work has primarily viewed tropical circulation in two dimensions, as a pair of zonal-mean Hadley cells on either side of the rain belt that are displaced north and south by perturbations in hemispheric energy budgets, causing the atmosphere to transport heat into the cooler hemisphere. Here we attempt to move beyond this zonal-mean perspective, motivated by arguments that the Asian monsoon system, rather than the zonal-mean circulation, plays the dominant role in annual-mean heat transport into the southern hemisphere in the modern climate (Heaviside and Czaja, 2012; Marshall et al., 2014). We explore a range of climate change experiments, including simulations of North Atlantic cooling and mid-Holocene climate, to test whether changes in interhemispheric atmospheric heat transport are primarily driven by the mean Hadley circulation, the Asian monsoon system, or other regional-scale atmospheric circulation changes. The scalings that this work identifies between Asian monsoon changes and atmospheric heat transport help to provide quantitative insights into Asian monsoon variability in past climates. References cited: Donohoe, A. et al., (2013) Journal of Climate 26, 3597-3618. Heaviside, C. and Czaja, A. (2012) Quart. J. Royal Met. Soc. 139, 2181-2189. Marshall, J. et al., (2014) Climate Dynamics 42, 1967-1979.

Development of Genetic Occurrence Models for Geothermal Prospecting

NASA Astrophysics Data System (ADS)

Walker, J. D.; Sabin, A.; Unruh, J.; Monastero, F. C.; Combs, J.

2007-12-01

Exploration for utility-grade geothermal resources has mostly relied on identifying obvious surface manifestations of possible geothermal activity, e.g., locating and working near steaming ground or hot springs. This approach has lead to the development of over 130 resources worldwide, but geothermal exploration done in this manner is akin to locating hydrocarbon plays by searching for oil seeps. Confining exploration to areas with such features will clearly not discover a blind resource, that is, one that does not have surface expression. Blind resources, however, constitute the vast majority of hydrocarbon plays; this may be the case for geothermal resources as well. We propose a geothermal exploration strategy for finding blind systems that is based on an understanding of the geologic processes that transfer heat from the mantle to the upper crust and foster the conditions for hydrothermal circulation or enhanced geothermal exploration. The strategy employs a genetically based screening protocol to assess potential geothermal sites. The approach starts at the plate boundary scale and progressively focuses in on the scale of a producing electrical-grade field. Any active margin or hot spot is a potential location for geothermal resources. Although Quaternary igneous activity provides a clear indication of active advection of hot material into the upper crust, it is not sufficient to guarantee a potential utility-grade resource. Active faulting and/or evidence of high strain rates appear to be the critical features associated with areas of utility-grade geothermal potential. This is because deformation on its own can advect sufficient heat into the upper crust to create conditions favorable for geothermal exploitation. In addition, active deformation is required to demonstrate that open pathways for circulation of geothermal fluids are present and/or can be maintained. The last step in the screening protocol is to identify any evidence of geothermal activity, including high heat flow, anomalous temperature water wells, high-temperature indications from aqueous geothermometry and geochemistry, Pliocene or younger ages from low-temperature thermochronometers, as well as more obvious factors such as geysers and fumaroles (which by definition will be missing for blind resources). Our occurrence-model strategy inverts the current approach that relies first on obvious evidence of geothermal activity. We evaluated our approach by retrospectively applying the protocol to the characteristics of producing geothermal fields, and in all cases, known resource areas fit the parameters identified from a genetic perspective.

Status of the planar electrostatic gradiometer GREMLIT for airborne geodesy

NASA Astrophysics Data System (ADS)

Boulanger, D.; Foulon, B.; Lebat, V.; Bresson, A.; Christophe, B.

2016-12-01

Taking advantage of technologies, developed by ONERA for the GRACE and GOCE space missions, the GREMLIT airborne gravity gradiometer is based of a planar electrostatic gradiometer configuration. The feasibility of the instrument and of its performance was proved by realistic simulations, based on actual data and recorded environmental aircraft perturbations, with performance of about one Eötvös along the two horizontal components of the gravity gradient. In order to assess the operation of the electrostatic gradiometer on its associated stabilized platform, a one axis prototype has also been built. The next step is the realization of the stabilization platform, controlled by the common mode outputs of the instrument itself, in order to reject the perturbations induced by the airborne environment in the horizontal directions. One of the interests of the GREMLIT instrument is the possibility of an easy hybrid configuration with a vertical one axis Cold Atoms Interferometer gravity gradiometer called GIBON and also under development at ONERA. In such hybrid instrument, The CAI instrument takes also advantage of the platform stabilized by the electrostatic one. The poster will emphasize the status of realization of the instrument and of its stabilized platform.

High stability laser for next generation gravity missions

NASA Astrophysics Data System (ADS)

Nicklaus, K.; Herding, M.; Wang, X.; Beller, N.; Fitzau, O.; Giesberts, M.; Herper, M.; Barwood, G. P.; Williams, R. A.; Gill, P.; Koegel, H.; Webster, S. A.; Gohlke, M.

2017-11-01

With GRACE (launched 2002) and GOCE (launched 2009) two very successful missions to measure earth's gravity field have been in orbit, both leading to a large number of publications. For a potential Next Generation Gravity Mission (NGGM) from ESA a satellite-to-satellite tracking (SST) scheme, similar to GRACE is under discussion, with a laser ranging interferometer instead of a Ka-Band link to enable much lower measurement noise. Of key importance for such a laser interferometer is a single frequency laser source with a linewidth <10 kHz and extremely low frequency noise down to 40 Hz / √Hz in the measurement frequency band of 0.1 mHz to 1 Hz, which is about one order of magnitude more demanding than LISA. On GRACE FO a laser ranging interferometer (LRI) will fly as a demonstrator. The LRI is a joint development between USA (JPL,NASA) and Germany(GFZ,DLR). In this collaboration the JPL contributions are the instrument electronics, the reference cavity and the single frequency laser, while STI as the German industry prime is responsible for the optical bench and the retroreflector. In preparation of NGGM an all European instrument development is the goal.

SAPS simulation with GITM/UCLA-RCM coupled model

NASA Astrophysics Data System (ADS)

Lu, Y.; Deng, Y.; Guo, J.; Zhang, D.; Wang, C. P.; Sheng, C.

2017-12-01

Abstract: SAPS simulation with GITM/UCLA-RCM coupled model Author: Yang Lu, Yue Deng, Jiapeng Guo, Donghe Zhang, Chih-Ping Wang, Cheng Sheng Ion velocity in the Sub Aurora region observed by Satellites in storm time often shows a significant westward component. The high speed westward stream is distinguished with convection pattern. These kind of events are called Sub Aurora Polarization Stream (SAPS). In March 17th 2013 storm, DMSP F18 satellite observed several SAPS cases when crossing Sub Aurora region. In this study, Global Ionosphere Thermosphere Model (GITM) has been coupled to UCLA-RCM model to simulate the impact of SAPS during March 2013 event on the ionosphere/thermosphere. The particle precipitation and electric field from RCM has been used to drive GITM. The conductance calculated from GITM has feedback to RCM to make the coupling to be self-consistent. The comparison of GITM simulations with different SAPS specifications will be conducted. The neutral wind from simulation will be compared with GOCE satellite. The comparison between runs with SAPS and without SAPS will separate the effect of SAPS from others and illustrate the impact on the TIDS/TADS propagating to both poleward and equatorward directions.

Crustal density contrast detection by global gravity and topography models and in-situ gravity observations

NASA Astrophysics Data System (ADS)

Claessens, S. J.

2016-12-01

Mass density contrasts in the Earth's crust can be detected using an inversion of terrestrial or airborne gravity data. This contribution shows a technique to detect short-scale density contrasts using in-situ gravity observations in combination with a high-resolution global gravity model that includes variations in the gravity field due to topography. The technique is exemplified at various test sites using the Global Gravity Model Plus (GGMplus), which is a 7.2 arcsec resolution model of the Earth's gravitational field, covering all land masses and near-coastal areas within +/- 60° latitude. The model is a composite of GRACE and GOCE satellite observations, the EGM2008 global gravity model, and short-scale topographic gravity effects. Since variations in the Earth's gravity field due to topography are successfully modelled by GGMplus, any remaining differences with in-situ gravity observations are primarily due to mass density variations. It is shown that this technique effectively filters out large-scale density variations, and highlights short-scale near-surface density contrasts in the Earth's crust. Numerical results using recent high-density gravity surveys are presented, which indicate a strong correlation between density contrasts found and known lines of geological significance.

Large-scale traveling atmospheric disturbances (LSTADs) in the thermosphere inferred from CHAMP, GRACE, and SETA accelerometer data

NASA Astrophysics Data System (ADS)

Bruinsma, Sean L.; Forbes, Jeffrey M.

2010-08-01

Densities derived from accelerometer measurements on the GRACE, CHAMP, and Air Force/SETA satellites near 490, 390, and 220 km, respectively, are used to elucidate global-scale characteristics of traveling atmospheric disturbances (TADs). Several characteristics elucidated in numerical simulations are confirmed in this study, namely: (1) propagation speeds increase from the lower thermosphere to the upper thermosphere; (2) propagation to the equator and even into the opposite hemisphere can occur; (3) greater attenuation of TADs occurs during daytime and at higher levels of solar activity (i.e., more wave activity during nighttime and solar minimum), presumably due to the greater influence of ion drag. In addition, we find that the occurrence of significant TAD activity emanating from the auroral regions does not reflect a clear relation with the level of planetary magnetic activity as measured by Kp. There is also evidence of waves originating in the tropics, presumably due to convective sources; to some extent this may contribute to the Kp and solar flux relationships noted above. Further elucidation of local time, season, and altitude dependences of TAD propagation characteristics may be forthcoming from density measurements from the GOCE and Swarm missions.

Efficient determination of the uncertainty for the optimization of SPECT system design: a subsampled fisher information matrix.

PubMed

Fuin, Niccolo; Pedemonte, Stefano; Arridge, Simon; Ourselin, Sebastien; Hutton, Brian F

2014-03-01

System designs in single photon emission tomography (SPECT) can be evaluated based on the fundamental trade-off between bias and variance that can be achieved in the reconstruction of emission tomograms. This trade off can be derived analytically using the Cramer-Rao type bounds, which imply the calculation and the inversion of the Fisher information matrix (FIM). The inverse of the FIM expresses the uncertainty associated to the tomogram, enabling the comparison of system designs. However, computing, storing and inverting the FIM is not practical with 3-D imaging systems. In order to tackle the problem of the computational load in calculating the inverse of the FIM, a method based on the calculation of the local impulse response and the variance, in a single point, from a single row of the FIM, has been previously proposed for system design. However this approximation (circulant approximation) does not capture the global interdependence between the variables in shift-variant systems such as SPECT, and cannot account e.g., for data truncation or missing data. Our new formulation relies on subsampling the FIM. The FIM is calculated over a subset of voxels arranged in a grid that covers the whole volume. Every element of the FIM at the grid points is calculated exactly, accounting for the acquisition geometry and for the object. This new formulation reduces the computational complexity in estimating the uncertainty, but nevertheless accounts for the global interdependence between the variables, enabling the exploration of design spaces hindered by the circulant approximation. The graphics processing unit accelerated implementation of the algorithm reduces further the computation times, making the algorithm a good candidate for real-time optimization of adaptive imaging systems. This paper describes the subsampled FIM formulation and implementation details. The advantages and limitations of the new approximation are explored, in comparison with the circulant approximation, in the context of design optimization of a parallel-hole collimator SPECT system and of an adaptive imaging system (similar to the commercially available D-SPECT).

Presurgical weight loss affects tumour traits and circulating biomarkers in men with prostate cancer

PubMed Central

Demark-Wahnefried, Wendy; Rais-Bahrami, Soroush; Desmond, Renee A; Gordetsky, Jennifer B; Hunter, Gary R; Yang, Eddy S; Azrad, Maria; Frugé, Andrew D; Tsuruta, Yuko; Norian, Lyse A; Segal, Roanne; Grizzle, William E

2017-01-01

Background: Obesity is associated with aggressive prostate cancer. To explore whether weight loss favourably affects tumour biology and other outcomes, we undertook a presurgical trial among overweight and obese men with prostate cancer. Methods: This single-blinded, two-arm randomised controlled trial explored outcomes of a presurgical weight loss intervention (WLI) that promoted ∼1 kg per week loss via caloric restriction and increased physical activity (PA). Forty overweight/obese men with clinically confirmed prostate cancer were randomised to the WLI presurgery or to a control arm; changes in weight, body composition, quality-of-life, circulating biomarkers, gene expression, and immunohistochemical markers in tumour and benign prostatic tissue were evaluated. Results: The study period averaged 50 days. Mean (s.d.) change scores for the WLI vs control arms were as follows: weight: −4.7 (3.1) kg vs −2.2 (4.4) kg (P=0.0508); caloric intake: −500 (636) vs −159 (600) kcal per day (P=0.0034); PA: +0.9 (3.1) vs +1.7 (4.6) MET-hours per day (NS); vitality: +5.3 (7.l4) vs −1.8 (8.1) (P=0.0491); testosterone: +55.1 (86.0) vs −48.3 (203.7) ng dl−1 (P=0.0418); sex hormone-binding globulin: +14.0 (14.6) vs +1.8 (7.6) nmol l−1 (P=0.0023); and leptin: −2.16 (2.6) vs −0.03 (3.75) (P=0.0355). Follow-up Ki67 was significantly higher in WLI vs control arms; median (interquartile range): 5.0 (2.5,10.0) vs 0.0 (0.0,2.5) (P=0.0061) and several genes were upregulated, for example, CTSL, GSK3B, MED12, and LAMC2. Conclusions: Intentional weight loss shows mixed effects on circulating biomarkers, tumour gene expression, and proliferative markers. More study is needed before recommending weight loss, in particular rapid weight loss, among men with prostate cancer. PMID:28881355

Outflow Channels Influencing Martian Climate: Global Circulation Model Simulations with Emplaced Water

NASA Technical Reports Server (NTRS)

Santiago, D. L.; Colaprete, A.; Haberle, R. M.; Sloan, L. C.; Asphaug, E. I.

2005-01-01

The existence of surface water on Mars in past geologic epochs is inferred on the basis of geomorphologic interpretation of spaceflight images, and is supported by the recent Mars Odyssey identification of ice-rich soils [1]. The Mars Exploration Rovers have provided further chemical evidence for past surface hydrologic activity [2]. One issue is whether this water-rich climate ever existed in a steady state, or whether it was triggered by catastrophic events such as large impacts [3], and/ or catastrophic outburst floods, the topic of consideration here.

Space station architectural elements model study. Space station human factors research review

NASA Technical Reports Server (NTRS)

Taylor, Thomas C.; Khan, Eyoub; Spencer, John; Rocha, Carlos; Cliffton, Ethan Wilson

1987-01-01

Presentation visuals and an extended abstract represent a study to explore and analyze the interaction of major utilities distribution, generic workstation, and spatial composition of the SPACEHAB space station module. Issues addressed include packing densities vs. circulation, efficiency of packing vs. standardization, flexibility vs. diversity, and composition of interior volume as space for living vs. residual negative volume. The result of the study is expected to be a series of observations and preliminary evaluation criteria which focus on the productive living environment for a module in orbit.

Opportunity In Situ Geologic Context of Aqueous Alteration Along Offsets in the Rim of Endeavour Crater

NASA Technical Reports Server (NTRS)

Crumpler, L. S.; Arvidson, R. E.; Farrand, W. H.; Golombek, M. P.; Grant, J. A.; Ming, D. W.; Mittlefehldt, D. W.; Parker, T. J.

2015-01-01

Mars Exploration Rover Opportunity traversed 7.9 km and 27 degrees of arc along the rim of the 22 km-diameter Noachian "Endeavour" impact crater since its arrival 1200 sols ago. Areas of aqueous and low-grade thermal alteration, and changes in structure, attitude, and macroscopic texture of outcrops are notable across several discontinuities between segments of the crater rim. The discontinuities and other post-impact joints and fractures coincide with sites of apparent deep fluid circulation processes responsible for thermal and chemical alteration of local outcrops.

Design of a walking robot

NASA Technical Reports Server (NTRS)

Whittaker, William; Dowling, Kevin

1994-01-01

Carnegie Mellon University's Autonomous Planetary Exploration Program (APEX) is currently building the Daedalus robot; a system capable of performing extended autonomous planetary exploration missions. Extended autonomy is an important capability because the continued exploration of the Moon, Mars and other solid bodies within the solar system will probably be carried out by autonomous robotic systems. There are a number of reasons for this - the most important of which are the high cost of placing a man in space, the high risk associated with human exploration and communication delays that make teleoperation infeasible. The Daedalus robot represents an evolutionary approach to robot mechanism design and software system architecture. Daedalus incorporates key features from a number of predecessor systems. Using previously proven technologies, the Apex project endeavors to encompass all of the capabilities necessary for robust planetary exploration. The Ambler, a six-legged walking machine was developed by CMU for demonstration of technologies required for planetary exploration. In its five years of life, the Ambler project brought major breakthroughs in various areas of robotic technology. Significant progress was made in: mechanism and control, by introducing a novel gait pattern (circulating gait) and use of orthogonal legs; perception, by developing sophisticated algorithms for map building; and planning, by developing and implementing the Task Control Architecture to coordinate tasks and control complex system functions. The APEX project is the successor of the Ambler project.

Design of a walking robot

NASA Astrophysics Data System (ADS)

Whittaker, William; Dowling, Kevin

1994-03-01

Carnegie Mellon University's Autonomous Planetary Exploration Program (APEX) is currently building the Daedalus robot; a system capable of performing extended autonomous planetary exploration missions. Extended autonomy is an important capability because the continued exploration of the Moon, Mars and other solid bodies within the solar system will probably be carried out by autonomous robotic systems. There are a number of reasons for this - the most important of which are the high cost of placing a man in space, the high risk associated with human exploration and communication delays that make teleoperation infeasible. The Daedalus robot represents an evolutionary approach to robot mechanism design and software system architecture. Daedalus incorporates key features from a number of predecessor systems. Using previously proven technologies, the Apex project endeavors to encompass all of the capabilities necessary for robust planetary exploration. The Ambler, a six-legged walking machine was developed by CMU for demonstration of technologies required for planetary exploration. In its five years of life, the Ambler project brought major breakthroughs in various areas of robotic technology. Significant progress was made in: mechanism and control, by introducing a novel gait pattern (circulating gait) and use of orthogonal legs; perception, by developing sophisticated algorithms for map building; and planning, by developing and implementing the Task Control Architecture to coordinate tasks and control complex system functions. The APEX project is the successor of the Ambler project.

[The evaluation of psychological development in the dispensarios de lactantes (infant and toddler clinics) in Buenos Aires: medicine and psychology in Argentina, 1935-1942].

PubMed

Briolotti, Ana

2016-01-01

This article explores the medical use of techniques for psychological evaluation in the dispensarios de lactantes (infant and toddler clinics) in Buenos Aires within the framework of historical studies of psychology in Argentina. It analyzes the institutional environment in order to shed light on the framework of discourses within which the interest in controlling psychological development may be situated. It studies the tests used, the characteristics of application and the most significant results. It explores the vicissitudes of the professional field, in the light of which psychology was useful for consolidating the legitimacy of medical knowledge. It points out a divergence between this medical use of psychology and the production and circulation of psychological knowledge in academic and educational environments.

Effect of diesel leakage in circulating cooling water system on preponderant bacteria diversity and bactericidal effect of biocides.

PubMed

Zhong, Huiyun; Liu, Fang; Lu, Jinjin; Yang, Wei; Zhao, Chaocheng

2015-01-01

Petroleum products leakage results in adverse effect on the normal operation of a circulating cooling water system. However, relatively little research has been done to explore the effect of petroleum products leakage on circulating cooling water quality and biofilm preponderant bacteria diversity. Also, normal biocides application modes cannot fulfil the need for biofilm control. In this study, diesel oil was used as the experimental subject representing leaking petroleum products; the effect of diesel addition on biofilm preponderant bacteria diversity and the bactericidal effect of chlorine dioxide and tetradecyl dimethyl benzyl ammonium chloride (1427) was investigated. Bacterial community structures were examined by PCR-denaturing gradient gel electrophoresis and PCR cloning of 16S rDNA genes. Except for 100 mg/L diesel, increasing diesel concentration enhanced the biofilm detachment ratio compared with the control test. The microstructure of biofilm samples with 0, 300 and 900 mg/L diesel addition was observed. The species of preponderant bacteria in the biofilm sample with 300 mg/L diesel addition were more and the bacterial distribution was more uniform than those in the biofilm sample with 900 mg/L diesel addition. With ClO2 and 1427 addition, chemical oxygen demand increased, lipid phosphorus and bacterial count first decreased and then remained stable, and the bactericidal ratio first increased and then remained stable. Diesel addition variation has more obvious effect on ClO2 than 1427.

Long-circulating Janus nanoparticles made by electrohydrodynamic co-jetting for systemic drug delivery applications.

PubMed

Rahmani, Sahar; Villa, Carlos H; Dishman, Acacia F; Grabowski, Marika E; Pan, Daniel C; Durmaz, Hakan; Misra, Asish C; Colón-Meléndez, Laura; Solomon, Michael J; Muzykantov, Vladimir R; Lahann, Joerg

2015-01-01

Nanoparticles with controlled physical properties have been widely used for controlled release applications. In addition to shape, the anisotropic nature of the particles can be an important design criterion to ensure selective surface modification or independent release of combinations of drugs. Electrohydrodynamic (EHD) co-jetting is used for the fabrication of uniform anisotropic nanoparticles with individual compartments and initial physicochemical and biological characterization is reported. EHD co-jetting is used to create nanoparticles, which are characterized at each stage with scanning electron microscopy (SEM), structured illumination microscopy (SIM), dynamic light scattering (DLS) and nanoparticle tracking analysis (NTA). Surface immobilization techniques are used to incorporate polyethylene glycol (PEG) and I(125) radiolabels into the nanoparticles. Particles are injected in mice and the particle distribution after 1, 4 and 24 hours is assessed. Nanoparticles with an average diameter of 105.7 nm are prepared by EHD co-jetting. The particles contain functional chemical groups for further surface modification and radiolabeling. The density of PEG molecules attached to the surface of nanoparticles is determined to range between 0.02 and 6.04 ligands per square nanometer. A significant fraction of the nanoparticles (1.2% injected dose per mass of organ) circulates in the blood after 24 h. EHD co-jetting is a versatile method for the fabrication of nanoparticles for drug delivery. Circulation of the nanoparticles for 24 h is a pre-requisite for subsequent studies to explore defined targeting of the nanoparticles to a specific anatomic site.