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Sample records for cis opinion surveys

  1. Florida Employer Opinion Survey. Annual Report.

    ERIC Educational Resources Information Center

    Florida State Dept. of Education, Tallahassee. Div. of Vocational, Adult, and Community Education.

    Two surveys were directed to Florida employers that employed former vocational education students in 1988. The surveys obtained information describing employer opinions regarding general and specific vocational preparation of workers for employment. The 1989-90 employer general opinion survey examined hiring needs, general preparation, and…

  2. Food irradiation: Public opinion surveys

    SciTech Connect

    Kerr, S.D.

    1987-01-01

    The Canadian government are discussing the legislation, regulations and practical protocol necessary for the commercialization of food irradiation. Food industry marketing, public relations and media expertise will be needed to successfully introduce this new processing choice to retailers and consumers. Consumer research to date including consumer opinion studies and market trials conducted in the Netherlands, United States, South Africa and Canada will be explored for signposts to successful approaches to the introduction of irradiated foods to retailers and consumers. Research has indicated that the terms used to describe irradiation and information designed to reduce consumer fears will be important marketing tools. Marketers will be challenged to promote old foods, which look the same to consumers, in a new light. Simple like or dislike or intention to buy surveys will not be effective tools. Consumer fears must be identified and effectively handled to support a receptive climate for irradiated food products. A cooperative government, industry, health professional, consumer association and retailer effort will be necessary for the successful introduction of irradiated foods into the marketplace. Grocery Products Manufacturers of Canada is a national trade association of more than 150 major companies engaged in the manufacture of food, non-alcoholic beverages and array of other national-brand consumer items sold through retail outlets.

  3. [Opinion survey among nursing students on family].

    PubMed

    Fukuchi, Akemi

    2002-12-01

    Earlier discharges of patients from hospital are increasing needs for supports for home medical care, which is causing changes in the activities of medical providers for patients and family members. Meanwhile, it is suggested that the younger generation is more indifferent to family members along with the increase of nuclear families or households consisting of only one member. This time, the author conducted an opinion survey among nursing students for the purpose of understanding how nursing students think of the family and using the data as a reference for the education. The survey was conducted in FY2000 and FY2001 for the questions selected from the "National Lifestyle Popularity Survey". The results indicate that nursing students intend to have families while keeping working and are willing to fulfill their responsibilities as a family member of which relation is close. It is considered possible to guide nursing students to practice nursing respecting the position and feeling of the patient by letting them understand social changes and the individuality of the patient based on the way nursing students think of the family.

  4. Surveying Older Adults' Opinions on Housing: Recommendations for Policy

    ERIC Educational Resources Information Center

    Wagner, Shannon L.; Shubair, Mamdouh M.; Michalos, Alex C.

    2010-01-01

    There is paucity of research investigating opinions and attitudes of seniors 55 years of age and older in relation to housing accommodation and services sensitive to the needs of the senior population. We describe the results of a cross-sectional survey soliciting opinions and attitudes of seniors with respect to a variety of housing issues…

  5. Continuous Opinion Dynamics Under Bounded Confidence:. a Survey

    NASA Astrophysics Data System (ADS)

    Lorenz, Jan

    Models of continuous opinion dynamics under bounded confidence have been presented independently by Krause and Hegselmann and by Deffuant et al. in 2000. They have raised a fair amount of attention in the communities of social simulation, sociophysics and complexity science. The researchers working on it come from disciplines such as physics, mathematics, computer science, social psychology and philosophy. In these models agents hold continuous opinions which they can gradually adjust if they hear the opinions of others. The idea of bounded confidence is that agents only interact if they are close in opinion to each other. Usually, the models are analyzed with agent-based simulations in a Monte Carlo style, but they can also be reformulated on the agent's density in the opinion space in a master equation style. The contribution of this survey is fourfold. First, it will present the agent-based and density-based modeling frameworks including the cases of multidimensional opinions and heterogeneous bounds of confidence. Second, it will give the bifurcation diagrams of cluster configuration in the homogeneous model with uniformly distributed initial opinions. Third, it will review the several extensions and the evolving phenomena which have been studied so far, and fourth it will state some open questions.

  6. A Survey of Undergraduate Student Opinions.

    ERIC Educational Resources Information Center

    Church, Kathleen

    The results of the Student Reaction to College survey, given to students at Arizona's three public universities, are presented as one of the working papers in the final report of the Arizona Board of Regents' Task Force on Excellence, Efficiency and Competitiveness. Results indicate the following: students from all three universities are very…

  7. A Survey of Parental Opinions on Corporal Punishment in Schools.

    ERIC Educational Resources Information Center

    Kelly, Patrick C.; And Others

    1985-01-01

    In a survey of 129 parents of military dependents, 51% supported the use of corporal punishment in schools and 37% disagreed. Analysis of the responses displayed a relationship between parental attitudes on the use of corporal punishment and opinion of the positive effects of physical punishment on children's behavior. (Author/CL)

  8. DIMENSIONS OF THE LEARNING ENVIRONMENT--THE SCHOOL OPINION SURVEY.

    ERIC Educational Resources Information Center

    RECTOR, WILLIAM H.; SHAW, MERVILLE C.

    THIS MONOGRAPH PRESENTS TECHNICAL AND STATISTICAL INFORMATION SUPPLEMENTAL TO PREVIOUS PUBLICATIONS CONCERNING THE GENERAL OUTLINE AND CHARACTERISTICS OF THE SCHOOL OPINION SURVEY (SOS), WHICH DELINEATES SIGNIFICANT PARAMETERS OF THE LEARNING ENVIRONMENT. THE INTRODUCTION INCLUDES THE GUIDANCE MODEL, THE NEED FOR THE SOS TO HELP PUPIL PERSONNEL…

  9. Student Opinions About Health Services at Miami. Survey Report.

    ERIC Educational Resources Information Center

    Keller, Michael J.

    A random sample of Miami University undergraduate and graduate students were surveyed to determine their opinions about health care at the university. Most of the questions dealt with the university's student health service and satisfaction with the quality of medical treatment at the facility, perception of the staff's performance and interest in…

  10. Student Opinion Survey, 1976. Research Report: BCC 1-77.

    ERIC Educational Resources Information Center

    Eagle, Norman

    A student opinion survey was administered to a sample of 1,100 students at Bronx Community College (BCC) in 1976. Respondent ethnicity distribution was 46.2% black, 29.1% hispanic, 17.0% white, 1.5% Oriental, and 6.3% other. More than half of the respondents were in either liberal arts and music (42.8%) or business curricula (21.8%). Results…

  11. Obstetricians’ Opinions of the Optimal Caesarean Rate: A Global Survey

    PubMed Central

    Cavallaro, Francesca L.; Cresswell, Jenny A.; Ronsmans, Carine

    2016-01-01

    Background The debate surrounding the optimal caesarean rate has been ongoing for several decades, with the WHO recommending an “acceptable” rate of 5–15% since 1997, despite a weak evidence base. Global expert opinion from obstetric care providers on the optimal caesarean rate has not been documented. The objective of this study was to examine providers’ opinions of the optimal caesarean rate worldwide, among all deliveries and within specific sub-groups of deliveries. Methods A global online survey of medical doctors who had performed at least one caesarean in the last five years was conducted between August 2013 and January 2014. Respondents were asked to report their opinion of the optimal caesarean rate—defined as the caesarean rate that would minimise poor maternal and perinatal outcomes—at the population level and within specific sub-groups of deliveries (including women with demographic and clinical risk factors for caesareans). Median reported optimal rates and corresponding inter-quartile ranges (IQRs) were calculated for the sample, and stratified according to national caesarean rate, institutional caesarean rate, facility level, and respondent characteristics. Results Responses were collected from 1,057 medical doctors from 96 countries. The median reported optimal caesarean rate was 20% (IQR: 15–30%) for all deliveries. Providers in private for-profit facilities and in facilities with high institutional rates reported optimal rates of 30% or above, while those in Europe, in public facilities and in facilities with low institutional rates reported rates of 15% or less. Reported optimal rates were lowest among low-risk deliveries and highest for Absolute Maternal Indications (AMIs), with wide IQRs observed for most categories other than AMIs. Conclusions Three-quarters of respondents reported an optimal caesarean rate above the WHO 15% upper threshold. There was substantial variation in responses, highlighting a lack of consensus around

  12. PVMapper: Report on the Second Public Opinion Survey

    SciTech Connect

    Juliet Carlisle; Jeffrey Joe; Stephanie Kane; Dave Koehler; David Solan

    2013-06-01

    This report has been developed as an integral part of the PVMapper project, funded by the U.S. Department of Energy’s Office of Energy Efficiency and Renewable Energy’s SunShot program. The objective of the SunShot program is to reduce the total costs of solar energy systems. The scope of PVMapper is to develop a geographic information system (GIS) based project planning tool to identify optimal utility-scale solar facility sites. The specific objectives of the project are to 1) develop the software on an open-source platform; 2) integrate the appropriate data sets and GIS layers; 3) include a measure of social risk and public acceptance; 4) enable customization of variable weights; 5) provide a free and accessible platform for software download; and 6) provide a sustainability plan to ensure future relevance of the software. When completed, PVMapper is intended to be used by solar developers, Authorities Having Jurisdiction (AHJs), and other interested parties. This project supports SunShot’s objective by reducing the non-hardware balance of system costs (“soft costs”) for utility-scale solar project development. In order to accomplish the third project objective – including a measure of social risk and public acceptance within PVMapper – the project team has developed a time-series public opinion survey, administered yearly over the course of the three-year project. This report highlights the results and preliminary analyses from the second survey in this series. While the results of this survey are valuable to both PVMapper and future utility-scale solar development, the time-series design is extremely important. The completion of the series enables the extension of the dataset to much richer information. For example, the research team altered this iteration to sharpen the focus on specific topics (those posing potentially higher risks) and target specific locations in the oversample (such as communities near existing facilities). Using similar

  13. Opinions Expressed by Students at the University of Nebraska at Omaha, 1989 Survey Results.

    ERIC Educational Resources Information Center

    Crawford, A. E., II

    1989-01-01

    Opinions of 681 University of Nebraska at Omaha students concerning college services and the college environment were surveyed, and results compared with four previous surveys. The survey utilized the standardized instrument developed by the American College Testing Corporation along with a series of local information questions. The survey's four…

  14. COMPENDIUM: SURVEYS EVALUATING KNOWLEDGE AND OPINIONS CONCERNING HYDROGEN AND FUEL CELL TECHNOLOGIES

    SciTech Connect

    Truett, Lorena Faith; Cooper, Christy; Schmoyer, Richard L

    2008-10-01

    This compendium updates a 2003 literature review of surveys of knowledge and opinions of hydrogen and fuel cell technologies. Its purpose is to ensure that results of comparable surveys are considered in surveys conducted by the U.S. Department of Energy (DOE). Over twice as many studies related to the DOE survey have been published since 2003 than prior to that date. The fact that there have been significantly more studies implies that there have been further demonstration projects and/or increased interest in hydrogen and fuel cell technologies. The primary findings of these 15 new surveys, all of which were conducted in Europe (E) or North America (NA), to the DOE surveys are as follows: 1.Respondents who are more educated are more accepting of hydrogen technologies (NA). 2.Respondents who are more knowledgeable about hydrogen and/or fuel cells are more accepting of hydrogen technologies (E, NA). 3.When asked about issues of trust, respondents generally expressed distrust of the government or political parties but trusted scientists and environmental protection organizations (E). 4.Technical knowledge about hydrogen and fuel cell technologies is low (E, NA). 5.Respondents may express opinions about a technology even when they are lacking in knowledge of that technology (E). 6.Women and men have different priorities when deciding on an automobile purchase (E). 7.Public acceptance to hydrogen is vulnerable to perceptions of decreased safety (E, NA). 8.Public acceptance to hydrogen is vulnerable to perceptions of increased cost (E, NA). The DOE surveys are similar to surveys that examine technical knowledge of hydrogen and fuel cell technologies, although the technical questions are certainly different. The DOE surveys are also similar to the opinion surveys in that they address many of the same issues, such as safety, sources of energy information, or trust. There are many differences between the surveys reviewed in this compendium and the DOE surveys. The

  15. Continuous Quality Improvement in Student Affairs: A Survey of Staff Opinions on the Work Environment.

    ERIC Educational Resources Information Center

    Malaney, Gary D.; Osit, Carla J.

    1998-01-01

    Analyzes the results of a survey which queried student affairs staff members about their opinions on the importance of and their satisfaction with 37 aspects of their work environments. Discusses results of the survey and addresses efforts to improve the work climate. (Contains 18 references.) (Author/GCP)

  16. City College of San Francisco 1997 Sexual Harassment Student Opinion Survey.

    ERIC Educational Resources Information Center

    City Coll. of San Francisco, CA. Office of Institutional Research, Planning and Grants.

    This document describes the findings of a 1997 sexual harassment student opinion survey conducted at City College of San Francisco. Survey questions were jointly developed by the Sexual Harassment Prevention Sub-Committee of the Diversity Advisory Committee and the Office of Research and Planning, approved by the College Advisory Council, and…

  17. A National Opinion Survey of Aviation Maintenance Training Regulations. Technical Report.

    ERIC Educational Resources Information Center

    Johnson, William B.; Ziegler, Charles F., Jr.

    A national survey examined the opinions of aircraft maintenance training school administrators and instructors concerning the suitability of Federal Aviation Regulation Part 147 (FAR 147) to regulate effectively today's training programs. Responding to the mail survey instrument were 163 persons representing 90 schools in 37 states. Included among…

  18. A Survey of Teachers' Opinions on the Primary Diploma Course in Scotland

    ERIC Educational Resources Information Center

    Nisbet, J.; And Others

    1977-01-01

    In response to a request from the General Teaching Council for Scotland, the Aberdeen University Education Department offered to carry out a survey of teachers' opinions on the Primary Diploma Courses in Scottish Colleges of Education. Surveys principals and teachers in their second year of teaching. (Author/RK)

  19. Latino Public Opinion Survey of Pre-Kindergarten Programs: Knowledge, Preferences, and Public Support

    ERIC Educational Resources Information Center

    Tomas Rivera Policy Institute, 2006

    2006-01-01

    Valencia, Perez & Echeveste (VPE) and the Tomas Rivera Policy Institute (TRPI) designed a survey to capture Latino adults' opinions about the benefits, importance, and costs associated with enrolling children in pre-kindergarten programs. The objective of the survey was to gauge support for government-subsidized pre-kindergarten programs among…

  20. The Development of the STEM Career Interest Survey (STEM-CIS)

    NASA Astrophysics Data System (ADS)

    Kier, Meredith W.; Blanchard, Margaret R.; Osborne, Jason W.; Albert, Jennifer L.

    2014-06-01

    Internationally, efforts to increase student interest in science, technology, engineering, and mathematics (STEM) careers have been on the rise. It is often the goal of such efforts that increased interest in STEM careers should stimulate economic growth and enhance innovation. Scientific and educational organizations recommend that efforts to interest students in STEM majors and careers begin at the middle school level, a time when students are developing their own interests and recognizing their academic strengths. These factors have led scholars to call for instruments that effectively measure interest in STEM classes and careers, particularly for middle school students. In response, we leveraged the social cognitive career theory to develop a survey with subscales in science, technology, engineering, and mathematics. In this manuscript, we detail the six stages of development of the STEM Career Interest Survey. To investigate the instrument's reliability and psychometric properties, we administered this 44-item survey to over 1,000 middle school students (grades 6-8) who primarily were in rural, high-poverty districts in the southeastern USA. Confirmatory factor analyses indicate that the STEM-CIS is a strong, single factor instrument and also has four strong, discipline-specific subscales, which allow for the science, technology, engineering, and mathematics subscales to be administered separately or in combination. This instrument should prove helpful in research, evaluation, and professional development to measure STEM career interest in secondary level students.

  1. The 2008 "Education Next"-PEPG Survey of Public Opinion

    ERIC Educational Resources Information Center

    Howell, William G.; West, Martin R.; Peterson, Paul E.

    2008-01-01

    Americans clearly have had their fill of a sluggish economy and an unpopular war. Their frustration now may also extend to public education. This article presents the results of the second annual national survey of U.S. adults conducted under the auspices of "Education Next" and the Program on Education Policy and Governance (PEPG) at…

  2. Who's Who Among American High School Students: Eleventh National Opinion Survey.

    ERIC Educational Resources Information Center

    Education Communications, Inc., Northbrook, IL.

    An awareness of student opinions is important, because today's students are tomorrow's leaders. The eleventh annual "Who's Who Among American High School Students" questionnaire was completed by 24,000 high school juniors and seniors identified as student leaders and high achievers. The survey showed that although high achievers expressed little…

  3. Climate Change to the Year 2000: A Survey of Expert Opinion.

    ERIC Educational Resources Information Center

    Institute for the Future, Menlo Park, CA.

    This survey of expert opinion was conducted by the National Defense University, Washington, D.C. to quantify the likelihood of significant changes in climate and their practical consequences. The major objectives of the study are embodied in four tasks. This publication presents the results of the first task only: the definition and estimation of…

  4. Evaluation of the disturbance caused by aircraft noise by opinion surveys

    NASA Technical Reports Server (NTRS)

    Bremond, J.

    1981-01-01

    A survey on the disturbance caused by aircraft noise was evaluated. The use of a questionnaire as a scale rather than considering isolated question responses is seen as more objective. A standardized structure for questionnaires of the opinion surveys on aircraft noise, which includes a set of questions permitting the analysis of the disturbance caused by different daily activities is recommended. The statistical processing of the answers, to achieve the most reliable evaluation of disturbance felt are discussed.

  5. Survey of stakeholders' opinions of community psychiatric nursing services.

    PubMed

    Shanley, E; Watson, G; Cole, A

    2001-06-01

    The paper describes a telephone survey of the views of representatives of users, purchasers and providers of community psychiatric nursing services on services in Scotland. The telephone interview protocol was based on seven themes derived from interviewing 63 users, purchasers and providers throughout the UK. Descriptive statistics were used to present the responses in the survey to the forced choice questions. Responses to the open ended questions were coded, categorized and computed. The paper describes the responses by the major stakeholders to each of the themes. Overall, the quality of the existing services was placed in the 'good' category. However, criticism was directed at the insufficient numbers of Community Psychiatric Nurses in the service, the inadequate amount of time spent with clients and their poorly organized method of working. Other findings and stakeholders' recommendations are discussed.

  6. Survey of Expert Opinion on Intelligence: Causes of International Differences in Cognitive Ability Tests

    PubMed Central

    Rindermann, Heiner; Becker, David; Coyle, Thomas R.

    2016-01-01

    Following Snyderman and Rothman (1987, 1988), we surveyed expert opinions on the current state of intelligence research. This report examines expert opinions on causes of international differences in student assessment and psychometric IQ test results. Experts were surveyed about the importance of culture, genes, education (quantity and quality), wealth, health, geography, climate, politics, modernization, sampling error, test knowledge, discrimination, test bias, and migration. The importance of these factors was evaluated for diverse countries, regions, and groups including Finland, East Asia, sub-Saharan Africa, Southern Europe, the Arabian-Muslim world, Latin America, Israel, Jews in the West, Roma (gypsies), and Muslim immigrants. Education was rated by N = 71 experts as the most important cause of international ability differences. Genes were rated as the second most relevant factor but also had the highest variability in ratings. Culture, health, wealth, modernization, and politics were the next most important factors, whereas other factors such as geography, climate, test bias, and sampling error were less important. The paper concludes with a discussion of limitations of the survey (e.g., response rates and validity of expert opinions). PMID:27047425

  7. Using expert opinion surveys to rank threats to endangered species: a case study with sea turtles.

    PubMed

    Donlan, C Josh; Wingfield, Dana K; Crowder, Larry B; Wilcox, Chris

    2010-12-01

    Little is known about how specific anthropogenic hazards affect the biology of organisms. Quantifying the effect of regional hazards is particularly challenging for species such as sea turtles because they are migratory, difficult to study, long lived, and face multiple anthropogenic threats. Expert elicitation, a technique used to synthesize opinions of experts while assessing uncertainty around those views, has been in use for several decades in the social science and risk assessment sectors. We conducted an internet-based survey to quantify expert opinion on the relative magnitude of anthropogenic hazards to sea turtle populations at the regional level. Fisheries bycatch and coastal development were most often ranked as the top hazards to sea turtle species in a geographic region. Nest predation and direct take followed as the second and third greatest threats, respectively. Survey results suggest most experts believe sea turtles are threatened by multiple factors, including substantial at-sea threats such as fisheries bycatch. Resources invested by the sea turtle community, however, appear biased toward terrestrial-based impacts. Results from the survey are useful for conservation planning because they provide estimates of relative impacts of hazards on sea turtles and a measure of consensus on the magnitude of those impacts among researchers and practitioners. Our survey results also revealed patterns of expert bias, which we controlled for in our analysis. Respondents with no experience with respect to a sea turtle species tended to rank hazards affecting that sea turtle species higher than respondents with experience. A more-striking pattern was with hazard-based expertise: the more experience a respondent had with a specific hazard, the higher the respondent scored the impact of that hazard on sea turtle populations. Bias-controlled expert opinion surveys focused on threatened species and their hazards can help guide and expedite species recovery plans.

  8. [Response rates in three opinion surveys performed through online questionnaires in the health setting].

    PubMed

    Aerny Perreten, Nicole; Domínguez-Berjón, Ma Felicitas; Astray Mochales, Jenaro; Esteban-Vasallo, María D; Blanco Ancos, Luis Miguel; Lópaz Pérez, Ma Ángeles

    2012-01-01

    The main advantages of online questionnaires are the speed of data collection and cost savings, but response rates are usually low. This study analyzed response rates and associated factors among health professionals in three opinion surveys in the autonomous region of Madrid. The participants, length of the questionnaire and topic differed among the three surveys. The surveys were conducted by using paid Internet software. The institutional e-mail addresses of distinct groups of health professionals were used. Response rates were highest in hospitals (up to 63%) and administrative services and were lowest in primary care (less than 33%). The differences in response rates were analyzed in primary care professionals according to age, sex and professional category and only the association with age was statistically significant. None of the surveys achieved a response rate of 60%. Differences were observed according to workplace, patterns of Internet usage, and interest in the subject.

  9. The Asilomar Survey: Stakeholders' Opinions on Ethical Issues Related to Brain-Computer Interfacing.

    PubMed

    Nijboer, Femke; Clausen, Jens; Allison, Brendan Z; Haselager, Pim

    2013-01-01

    Brain-Computer Interface (BCI) research and (future) applications raise important ethical issues that need to be addressed to promote societal acceptance and adequate policies. Here we report on a survey we conducted among 145 BCI researchers at the 4(th) International BCI conference, which took place in May-June 2010 in Asilomar, California. We assessed respondents' opinions about a number of topics. First, we investigated preferences for terminology and definitions relating to BCIs. Second, we assessed respondents' expectations on the marketability of different BCI applications (BCIs for healthy people, BCIs for assistive technology, BCIs-controlled neuroprostheses and BCIs as therapy tools). Third, we investigated opinions about ethical issues related to BCI research for the development of assistive technology: informed consent process with locked-in patients, risk-benefit analyses, team responsibility, consequences of BCI on patients' and families' lives, liability and personal identity and interaction with the media. Finally, we asked respondents which issues are urgent in BCI research.

  10. The Opinions of GP's Patients About Suicide, Assisted Suicide, Euthanasia, and Suicide Prevention: An Italian Survey.

    PubMed

    Poma, Stefano Zanone; Vicentini, Silvia; Siviero, Francesca; Grossi, Antonello; Toniolo, Emanuele; Baldo, Vincenzo; De Leo, Diego

    2015-08-01

    A survey about opinions on end-of-life issues of a population represented by 1,171 people in the waiting room of general practitioners' surgeries was conducted in a province of northern Italy. Most subjects did not consider suicide as a reasonable option even in cases of a serious and incurable disease. Moreover, subjects did not consider euthanasia as a possible option either; however, they did express an opposite attitude when considering euthanasia in a third-person perspective. People with a personal history of suicidal behavior appear to present as a different population, overall expressing more open attitudes.

  11. National Opinion Ballot Report, October 1993. Results of National Opinion Survey on U.S. Foreign Policy.

    ERIC Educational Resources Information Center

    Norpoth, Helmut

    This publication reports on the results of 35,793 high school participants in the Foreign Policy Association's 1993 study and discussion program focusing on opinions about U.S. foreign policy. The topics highlighted in the research include: (1) the U.S. in a New World; (2) the United Nations; (3) Germany's role; (4) China; (5) Trade; (6) Russian…

  12. Opinion of stakeholders on existing curriculum for postgraduate (MD) course in Pharmacology: A survey

    PubMed Central

    Badyal, Dinesh K.; Daniel, Sujit R.

    2016-01-01

    Objectives: To survey the opinion about various curricular components of Doctor of Medicine (MD) pharmacology curriculum in India by stakeholders, including faculty and students. Materials and Methods: An online survey was done to evaluate the various curricular components of MD pharmacology curriculum being used in India. A total of 393 respondents including faculty, MD students, and other stakeholders completed the survey. The survey was developed using SurveyMonkey platform and link to survey was E-mailed to stakeholders. The results were expressed as percentages. Results: There was a balanced representation of respondents from various designations, teaching experience, regions, and age groups. Most of the respondents (83%) were aware of the MD pharmacology curriculum. However, they reported that it is more inclined to knowledge domain. About half of respondents (53%) said that animal experiments are being used. The most common teaching methods mentioned are seminars (98.5%), journal clubs (95%), and practical exercises by postgraduates (73%), but there is less use of newer methods (25%) in theory and less of clinical pharmacology exercise (39%) in practical classes. The log books are maintained but not assessed regularly. Internal assessment is sparingly used. Conclusion: The MD pharmacology curriculum needs to be made uniform at the national level and updated to include the newer methods in teaching-learning and assessment. There should be sharing of newer methods at a common platform implemented at the national level. PMID:28031602

  13. Problems, Satisfactions and Habits of Off-Campus Students at UT-Knoxville. 1975 Commuter Opinion Survey. Final Report.

    ERIC Educational Resources Information Center

    Scroggins, Don; Haskins, Jack B.

    This is the last report on the Commuter Opinion Survey conducted during the spring quarter of 1975 at the University of Tennessee (UT) at Knoxville. It is a complete, detailed report on all findings and tabulations from the survey, including a statement of methodology. An important added feature is a complete cross-tabulation of all results by…

  14. Bed bugs, public health, and social justice: Part 2, An opinion survey.

    PubMed

    Eddy, Christopher; Jones, Susan C

    2011-04-01

    Bed bug infestations have resurged globally, nationally, and locally, yet the public health community in the U.S. has yet to mount a coordinated response to the escalating bed bug problem. Surveys of attendees at the 2009 National Environmental Health Association Annual Educational Conference & Exhibition, 2009 Ohio Association of Health Commissioners Fall Conference, 2009 Central Ohio Bed Bug Summit, and 2010 Hamilton County Council on Aging Annual Conference were conducted to gauge opinions about bed bugs. Survey results revealed that 90% of all respondents considered bed bugs to be a public health concern, and 73% indicated that bed bugs pose an environmental justice concern. These findings, which indicate that bed bugs are an inescapable public health mandate with environmental justice undertones, should rally public health agencies at federal, state, and local levels to respond with authority of agency to the escalating bed bug problem.

  15. Research capacity of respiratory therapists: A survey of views, opinions and barriers

    PubMed Central

    Martins, Concetta; Kenaszchuk, Chris

    2013-01-01

    BACKGROUND: Evidence-based practice (EBP) is increasing in health care services. This means that respiratory therapists (RTs) should be effective consumers, users and producers of scientific research pertaining to respiratory therapy technology and respiratory physiology. However, little is known about RT opinions and attitudes toward research. Survey instruments to measure them are also uncommon. OBJECTIVE: The present article presents the results of a survey of RTs regarding research attitudes including interest, self-perceived skill and barriers. METHODS: A survey was developed in consultation with practicing RTs and education researchers. It was fielded in six academic hospitals in Toronto, Ontario. Surveys were completed and returned anonymously. Descriptive statistics and associations were examined. Subgroup differences were tested using ANOVA methods. RESULTS: Surveys were completed by 112 RTs (response rate 26.9%). The majority (approximately 80%) of respondents agreed that respiratory therapy research is important, that research can advance the profession and that RTs are suited to performing respiratory therapy research. More than 70% were interested in performing research as long as barriers were eliminated. Among eight potential barriers, lack of time was ranked as the top barrier 59% of the time. Lack of interest in performing research was the least relevant barrier. RTs’ educational attainment was positively associated with willingness to perform research and belief in having the skills needed for research. CONCLUSION: Many RTs want to conduct research. They would need substantial support, including increased research exposure during respiratory therapy training, more time and support from trained researchers. PMID:26078597

  16. Opinions and trends in biomaterials education: report of a 2003 Society for Biomaterials survey.

    PubMed

    Karp, Jeffrey M; Friis, Elizabeth A; Dee, Kay C; Winet, Howard

    2004-07-01

    The Society for Biomaterials (SFB) aims to serve its members through acting as a forum for the exchange of information and ideas. To aid in the practical development of the SFB and more specifically biomaterials education, all active, associate, and student members were surveyed. In general, the survey asked questions regarding respondent demographics, experiences and activities with the SFB, and opinions about biomaterials education. Perceptions and needs of biomaterials-related education and career-related training practices were a specific focus of the survey. A total of 140 individuals responded to the survey for a response rate of 18%. Members from industry felt that new hires, in general, should be better trained in product development, regulatory issues for new materials and devices, and in the relevant testing required. When asked what was missing from their professional education, many respondents commented that business training in areas such as negotiations, management, and understanding the needs outside of academia was lacking. Also, many respondents seemed to have trouble identifying with what they were supposed to know and felt a "lack of set professional knowledge." This study has raised many ideas and questions that require further discussion. The results should ultimately be useful for helping the SFB decide how best to focus future efforts in biomaterials education.

  17. Public opinion on alcohol policies in the United States: results from a national survey.

    PubMed

    Wagenaar, A C; Harwood, E M; Toomey, T L; Denk, C E; Zander, K M

    2000-01-01

    We surveyed the U.S. non-institutionalized population age 18+ on opinions regarding 23 alcohol control policies (N = 7,021). The cooperation rate among contacted households was 70% and the overall response rate was 54%. Results showed high levels of public support for most alcohol control policies. Over 80% support restrictions on alcohol use in public places, such as parks, beaches, concert venues, and on college campuses. Eighty-two percent support increased alcohol taxes, provided the funds are used for treatment or prevention programs. Over 60% support alcohol advertising and promotion restrictions, such as banning billboard advertising, banning promotion at sporting events, or banning liquor and beer advertising on television. Multivariate regression analyses indicated significant relationships between alcohol policy opinions and a variety of sociodemographic, political orientation, and behavioral measures. However, the absolute differences in alcohol policy support across groups is small. There is a strong base of support for alcohol control policies in the U.S., and such support is found among whites and ethnics of color, young and old, rich and poor, and conservatives, moderates, and liberals.

  18. Brazilian obstetrician-gynecologists and abortion: a survey of knowledge, opinions and practices

    PubMed Central

    Goldman, Lisa A; García, Sandra G; Díaz, Juan; Yam, Eileen A

    2005-01-01

    Background Abortion laws are extremely restrictive in Brazil. The knowledge, opinions of abortion laws, and abortion practices of obstetrician-gynecologists can have a significant impact on women's access to safe abortion. Methods We conducted a mail-in survey with a 10% random sample of obstetrician-gynecologists affiliated with the Brazilian Federation of Obstetricians and Gynecologists. We documented participants' experiences performing abortion under a range of legal and illegal circumstances, and asked about which abortion techniques they had experience with. We used chi-square tests and crude logistic regression models to determine which sociodemographic, knowledge-related, or practice-related variables were associated with physician opinion. Results Of the 1,500 questionnaires that we mailed out, we received responses from 572 (38%). Less than half (48%) of the respondents reported accurate knowledge about abortion law and 77% thought that the law should be more liberal. One-third of respondents reported having previous experience performing an abortion, and very few of these physicians reported having experience with manual vacuum aspiration (MVA) or with misoprostol with either mifepristone or methotrexate. Physicians that favored liberalization of the law were more likely to have correct knowledge about abortion law, and to be in favor of public funding for abortion services. Conclusion Brazilian obstetrician-gynecologists need more information on abortion laws and on safe, effective abortion procedures. PMID:16288647

  19. National survey of provider opinions on controversial characteristics of liver transplant candidates.

    PubMed

    Secunda, Katharine; Gordon, Elisa J; Sohn, Min W; Shinkunas, Laura A; Kaldjian, Lauris C; Voigt, Michael D; Levitsky, Josh

    2013-04-01

    Candidate selection for liver transplantation presents challenging ethical issues that require balancing the principles of justice and utility. The goal of this study was to assess the opinions of U.S. transplant providers regarding the ways in which controversial medical and psychosocial characteristics influence patient eligibility for liver transplantation. An online, anonymous survey about adult patient characteristics was sent to providers (hepatologists, surgeons, psychiatrists, and social workers) at all 102 active adult liver transplant centers in the United States. A majority of the providers (251/444 or 56.5%) completed the survey. The providers were queried about 8 characteristics, and the 3 that were ranked most controversial were incarceration, marijuana use, and psychiatric diagnoses. Most providers identified a patient age ≥ 80 years (62.7%), a body mass index ≥ 45 kg/m2 (56.6%), and current incarceration with a lifetime sentence (54.7%) as absolute contraindications to liver transplantation. In a multivariate analysis, the identification of absolute contraindications varied significantly with the provider type, the center volume, and the geographical region. Less than half of the providers reported that their centers had written policies regarding most of the characteristics examined. In conclusion, providers differ significantly in their opinions on controversial patient characteristics and transplant contraindications. Along with a paucity of literature data on outcomes, these provider differences may play a role in the fact that many centers do not have formal policies for selecting patients with these characteristics. Evidence-based data on the outcomes of such patients are needed to guide the formation of written policies to better standardize eligibility criteria.

  20. A survey of biosecurity-related practices, opinions and communications across dairy farm veterinarians and advisors.

    PubMed

    Sayers, R G; Good, M; Sayers, G P

    2014-05-01

    Biosecurity at farm-level can often be poorly implemented, and lack of information has been cited by many studies as a potential explanation. Veterinary practitioners (VPs) and dairy advisors (DAs) play a central role in the provision of animal health and management services to dairy farmers. The objective of this study was to document and compare biosecurity-related practices and opinions across VPs and DAs in Ireland. A selection of veterinary experts (VEs) from outside of Ireland was also surveyed. Questionnaires were completed and response rates of 47% (VPs), 97% (DAs), and 65% (VEs) were achieved. Significant differences were identified in the promotion and implementation of biosecurity between VPs and DAs, with a higher proportion of VPs regularly receiving requests from (P = 0.004), and dispensing advice to (P < 0.0001), their farm clients. Communication between DAs and VPs was sub-optimal with over 60% of each group not in regular communication with each other. With regard to the main farmer motivation for biosecurity implementation, the majority of VPs (62%) prioritised external factors such as 'economic benefit' and 'mandatory obligation', while the majority of DAs prioritised health/animal-related factors (69%), which were similar to those of farmers (83.1%), although they remained significantly less likely (OR = 1.8) than farmers to choose such motivators (P = 0.005). Inconsistencies in the implementation of, and in opinions relating to, farm biosecurity were highlighted across all the groups surveyed emphasising the need for standardised information and improved communication.

  1. The U.S. Department of Energy Hydrogen Baseline Survey: Assessing Knowledge and opinions about Hydrogen Technology

    SciTech Connect

    Cooper, Christy; Truett, Lorena Faith; Schmoyer, Richard L

    2006-01-01

    To design and maintain its education program, the United States Department of Energy (DOE) Hydrogen Program conducted a statistically-valid national survey to measure knowledge and opinions of hydrogen among key target audiences. The Hydrogen Baseline Knowledge Survey provides a reference for designing the DOE hydrogen education strategy and will be used in comparisons with future surveys to measure changes in knowledge and opinions over time. The survey sampled four U.S. populations: (1) public; (2) students; (3) state and local government officials; and (4) potential large-scale hydrogen end-users in three business categories Questions measured technical understanding of hydrogen and opinions about hydrogen safety. Other questions assessed visions of the likelihood of future hydrogen applications and sources of energy information. Several important findings were discovered, including a striking lack of technical understanding across all survey groups, as well as a strong correlation between technical knowlege and opinions about safety: those who demonstrated an understanding of hydrogen technologies expressed the least fear of its safe use.

  2. The "Public Opinion Survey of Human Attributes-Stuttering" (POSHA-S): Summary Framework and Empirical Comparisons

    ERIC Educational Resources Information Center

    St. Louis, Kenneth O.

    2011-01-01

    Purpose: The "Public Opinion Survey of Human Attributes-Stuttering" ("POSHA-S") was developed to make available worldwide a standard measure of public attitudes toward stuttering that is practical, reliable, valid, and translatable. Mean data from past field studies as comparisons for interpretation of "POSHA-S" results are reported. Method: Means…

  3. GPs opinions and perceptions of chiropractic in Sweden and Norway: a descriptive survey

    PubMed Central

    2013-01-01

    Background In Sweden, chiropractic is not included in mainstream health care. In Norway chiropractic is a recognized health care profession. The aim of this study was to explore the perceptions of chiropractic among Swedish and Norwegian General Practitioners (GPs). Methods Eight hundred surveys in each country were distributed randomly by post to Swedish and Norwegian GPs offices. The survey contained two main sections: Experiences and opinions about chiropractic and referral patterns. The data were then described and compared between the countries. Results In Sweden the response rate was 44.8% and in Norway 45.3%. More than half of the Swedish GPs participating in this study stated that they had poor knowledge about chiropractic, while just a tenth of Norwegian GPs stated the same. Nearly all Norwegian GPs had some experience of chiropractic treatment whilst a fairly large number of the Swedish GPs said that they had no experience at all of chiropractic. It was twice as common for GPs in Norway to refer patients to a chiropractor as compared to Sweden. However, Swedish and Norwegian GPs agreed that chiropractors were competent to treat musculo-skeletal conditions with an adequate education to be part of mainstream medicine. Conclusions Swedish and Norwegian GPs agree that chiropractors are competent to treat musculoskeletal conditions. However, there are many differences in GPs perceptions of chiropractic between the two countries and the overall picture indicates that chiropractic is more accepted and recognised as a health care profession in Norway. PMID:24128386

  4. A pilot survey of trial court judges' opinions on pro se competence after Indiana v. Edwards.

    PubMed

    Knoll, James L; Leonard, Cecilia; Kaufman, Andrew R; Way, Bruce B

    2010-01-01

    In Indiana v. Edwards, the U.S. Supreme Court held that a higher standard may be required for pro se competence (PSC) than for competence to stand trial (CST). However, the Court refrained from elaborating a specific standard. The trial judge is in the best position to make more fine-tuned mental capacity decisions. This pilot study surveyed trial judges' opinions about PSC to help forensic evaluators structure their assessments. Eighteen of 400 New York State trial judges surveyed replied. Trial judges regarded disorders of cognitive impairment (n = 10) and psychosis (n = 4) to be potentially limiting for PSC. Responses relating to which domains should be assessed were heterogeneous, but the most common were intellectual and analytic abilities (n = 10), legal knowledge/experience (n = 9), and language abilities (n = 8). Several judges listed factors that are not traditionally part of CST evaluations, such as having a rational reason for proceeding pro se and a willingness to accept the assistance of standby counsel.

  5. Students' opinion of tobacco control policies recommended for US colleges: a national survey

    PubMed Central

    Rigotti, N; Regan, S; Moran, S; Wechsler, H

    2003-01-01

    Objective: Comprehensive tobacco control policies for US colleges and universities have been proposed by several groups in order to counter the rising use of tobacco by students enrolled in these institutions. Student opinion of these policies is not known, and concern about student opposition is one barrier that deters administrators from adopting the policies. This study measured student support for recommended college tobacco control policies. Design: Mailed survey of US college students (2001 Harvard School of Public Health College Alcohol Study). Setting: 119 nationally representative, four-year colleges and universities in the USA. Participants: 10 904 randomly selected undergraduate students enrolled at participating schools. Main outcome measures: Students' opinion of 7 proposed tobacco control policies. Results: A majority of students supported each policy. Over three quarters of students favoured smoke-free policies for all college buildings, residences, and dining areas, while 71% supported prohibiting tobacco advertising and sponsorship of campus social events, 59% favoured prohibiting tobacco sales on campus, and 51% supported smoke-free campus bars. All policies had more support among non-smokers than smokers (p < 0.001). Among smokers, support for policies was inversely related to intention to quit and intensity of tobacco consumption. Because college students' tobacco consumption is low, a majority of smokers favoured banning smoking in college buildings and dining areas and prohibiting tobacco marketing on campus. Conclusions: Student support for proposed campus tobacco control policies is strong, even among smokers, and broadly based across demographic subgroups. These findings should provide reassurance to college administrators who are considering adopting these policies. PMID:12958381

  6. DATA COLLECTION, QUALITY ASSURANCE, AND ANALYSIS PLAN FOR THE 2008/2009 HYDROGEN AND FUEL CELLS KNOWLEDGE AND OPINIONS SURVEYS

    SciTech Connect

    Schmoyer, Richard L; Truett, Lorena Faith; Diegel, Susan W

    2008-09-01

    The 2008/2009 Knowledge and Opinions Survey, conducted for the Department of Energy's Hydrogen Program will measure the levels of awareness and understanding of hydrogen and fuel cell technologies within five target populations: (1) the general public, (2) students, (3) personnel in state and local governments, (4) potential end users of hydrogen fuel and fuel cell technologies in business and industry, and (5) safety and code officials. The ultimate goal of the surveys is a statistically valid, nationally based assessment. Distinct information collections are required for each of the target populations. Each instrument for assessing baseline knowledge is targeted to the corresponding population group. While many questions are identical across all populations, some questions are unique to each respondent group. The biggest data quality limitation of the hydrogen survey data (at least of the general public and student components) will be nonresponse bias. To ensure as high a response rate as possible, various measures will be taken to minimize nonresponse, including automated callbacks, cycling callbacks throughout the weekdays, and availability of Spanish speaking interviewers. Statistical adjustments (i.e., sampling weights) will also be used to account for nonresponse and noncoverage. The primary objective of the data analysis is to estimate the proportions of target population individuals who would respond to the questions in the various possible ways. Data analysis will incorporate necessary adjustments for the sampling design and sampling weights (i.e., probability sampling). Otherwise, however, the analysis will involve standard estimates of proportions of the interviewees responding in various ways to the questions. Sample-weight-adjusted contingency table chi-square tests will also be computed to identify differences between demographic groups The first round of Knowledge and Opinions Surveys was conducted in 2004. Analysis of these surveys produced a

  7. Maxillofacial prosthetic rehabilitation in the UK: a survey of maxillofacial prosthetists' and technologists' attitudes and opinions.

    PubMed

    Hatamleh, M M; Haylock, Colin; Watson, J; Watts, D C

    2010-12-01

    Maxillofacial prostheses are constructed by maxillofacial prosthetists and technologists (MPTs), as an alternative treatment when maxillofacial defects cannot be surgically fulfilled. A questionnaire was conducted surveying 220 MPTs working in all UK maxillofacial units about their opinions, attitudes, and experience regarding several aspects related to maxillofacial silicone prostheses. Numbers and percentages of maxillofacial prostheses, their retention method, serviceability, reduced serviceability causes, and digital technologies (DT) used in constructing prostheses were analysed. Thousand hundred and ninety-three prostheses were constructed (42% ocular, 31% auricular, 13% orbital, 12% nasal, 1% composite, more than one facial prosthesis). Adhesives commonly retained orbital (48%) and nasal (45%) prostheses. Implant-retained bars commonly retained auricular prostheses (70%). Ocular prostheses were entirely retained by undercuts. Implant-retained prostheses remained serviceable for twice as long (19-24 months) as adhesive-retained prostheses (7-12 months). Causes for prosthesis replacement included colour changes (71%), poor maintenance (41%), and silicone tear (37%). Thirty-one percent of MPTs used DT computer software and programs for designing and constructing maxillofacial prostheses. In conclusion, adhesives, implant-retained bars and magnets are commonly used retentive methods. Prosthesis failure is caused mainly by colour change, poor maintenance, silicone tear and delamination. Different DTs are used by one-third of MPTs.

  8. Policy implications of a national public opinion survey on abortion in Mexico.

    PubMed

    García, Sandra G; Tatum, Carrie; Becker, Davida; Swanson, Karen A; Lockwood, Karin; Ellertson, Charlotte

    2004-11-01

    In Mexico, recent political events have drawn increased public attention to the subject of abortion. In 2000, using a national probability sample, we surveyed 3000 Mexicans aged 15-65 about their knowledge and opinions on abortion. Forty-five per cent knew that abortion was sometimes legal in their state, and 79% felt that abortion should be legal in some circumstances. A majority of participants believed that abortion should be legal when a woman's life is at risk (82%), a woman's health is in danger (76%), pregnancy results from rape (64%) or there is a risk of fetal impairment (53%). Far fewer respondents supported legal abortion when a woman is a minor (21%), for economic reasons (17%), when a woman is single (11%) or because of contraceptive failure (11%). In spite of the influence of the Church, most Mexican Catholics believed the Church and legislators' personal religious beliefs should not factor into abortion legislation, and most supported provision of abortions in public health services in cases when abortion is legal. To improve safe, legal abortion access in Mexico, efforts should focus on increasing public knowledge of legal abortion, decreasing the Church's political influence on abortion legislation, reducing the social stigma associated with sexuality and abortion, and training health care providers to offer safe, legal abortions.

  9. Moms and Schools Survey: Nationwide Public Opinion on Schooling. Polling Paper No. 8

    ERIC Educational Resources Information Center

    DiPerna, Paul

    2012-01-01

    Moms and Schools Educational Choice, conducted by Braun Research, Inc. (BRI), measures Americans views on area schools (district, charter, or private), school type preferences, and school vouchers. In this paper, Moms, report response levels of public opinion. For some questions, discussion to examine differences of voter opinion (sometimes using…

  10. Survey of Parent Opinions on Modular Scheduling at General William Mitchell High School.

    ERIC Educational Resources Information Center

    Grady, Roslyn M.

    Mitchell High has been operating under a modular scheduling system for two years. Earlier studies have measured student and faculty opinion. This study was designed to sample parent opinion. Four hundred parents, constituting a 20% random sampling of the 2,000 students enrolled in grades 10-12, were mailed questionnaires in May 1969. Responses…

  11. The Dimensions of Privacy: A National Opinion Research Survey of Attitudes Toward Privacy.

    ERIC Educational Resources Information Center

    Westin, Alan F.; And Others

    This report of a Louis Harris poll on national opinions toward privacy includes the questions asked of each respondent and the responses given in categories related to age, sex, employment, income, and other factors. There are chapters on privacy and the individual; personal privacy in relation to governmental and business institutions; privacy…

  12. Public Opinion regarding Juvenile Life without Parole in Consecutive Statewide Surveys

    ERIC Educational Resources Information Center

    Kubiak, Sheryl Pimlott; Allen, Terrence

    2011-01-01

    Abolition of the death penalty results in life without parole (LWOP) as the most severe sanction for convicted juveniles. Although internationally the use of LWOP for juveniles is rare, 2,225 youth have been sentenced to LWOP within the United States. To address the dearth of public opinion on the issue, the authors proposed questions to the…

  13. Adaptation and Validation of the Brief Sexual Opinion Survey (SOS) in a Colombian Sample and Factorial Equivalence with the Spanish Version

    PubMed Central

    Sierra, Juan Carlos; Soler, Franklin

    2016-01-01

    Attitudes toward sexuality are a key variable for sexual health. It is really important for psychology and education to have adapted and validated questionnaires to evaluate these attitudes. Therefore, the objective of this research was to adapt, validate and calculate the equivalence of the Colombia Sexual Opinion Survey as compared to the same survey from Spain. To this end, a total of eight experts were consulted and 1,167 subjects from Colombia and Spain answered the Sexual Opinion Survey, the Sexual Assertiveness Scale, the Massachusetts General Hospital-Sexual Functioning Questionnaire, and the Sexuality Scale. The evaluation was conducted by online and the results show adequate qualitative and quantitative properties of the items, with adequate reliability and external validity and compliance with the strong invariance between the two countries. Consequently, the Colombia Sexual Opinion Survey is a valid and reliable scale and its scores can be compared with the ones from the Spain survey, with minimum bias. PMID:27627114

  14. The U.S. Department of Energy Hydrogen Baseline Survey: Assessing Knowledge and Opinions about Hydrogen Technology

    SciTech Connect

    Cooper, Christy; Truett, Lorena Faith; Schmoyer, Richard L

    2006-01-01

    Data were collected in surveys of four component populations. The purpose was to serve as a reference for designing a hydrogen education program and as a baseline for measuring changes in understanding and awareness over time. Comparisons of the baseline data with future results will be made when the survey is fielded again (2008 and 2011). The methodology was successful in measuring knowledge levels and opinions of the target populations. Because the survey instruments were very similar, comparisons could be made among the target populations. These comparisons showed wide differences in knowledge levels between the government agencies and the other populations. General public, students, and potential large scale end user respondents had a general lack of knowledge about hydrogen and fuel cell technologies. There was a correlation between technical knowledge of hydrogen fuel cell technologies and opinions about the safe use of hydrogen. Respondents who demonstrated a greater understanding of the concepts of a hydrogen economy and hydrogen fuel cell technology expressed less fear about the safe use of hydrogen.

  15. [Value of public opinion polls for evaluating the acceptability of epidemiologic surveys in urban areas].

    PubMed

    Boutin, J P; Lahanier, D; Roux, J

    1989-01-01

    A prevalence study on non communicable diseases related to nutrition, alcoholism and tabagism is planned in French Polynesia. The methodology used, although complicated, has been successful in insular states of the South Pacific with either traditional or transitional ways of life. Acceptability level of the study in the urban area of Papeete (Tahiti) has been tested by a public opinion poll using the quota method in order to obtain valuable information on feasibility of the project. The public opinion poll showed that 75% of people would participate, 19.5% would be reluctant and 5.5% would hesitate. The good results must be carefully interpreted with regards to the multi-ethnic structure of French Polynesian population, and to the limits of the quota method.

  16. Climate Change and Infectious Disease Risk in Western Europe: A Survey of Dutch Expert Opinion on Adaptation Responses and Actors.

    PubMed

    Akin, Su-Mia; Martens, Pim; Huynen, Maud M T E

    2015-08-18

    There is growing evidence of climate change affecting infectious disease risk in Western Europe. The call for effective adaptation to this challenge becomes increasingly stronger. This paper presents the results of a survey exploring Dutch expert perspectives on adaptation responses to climate change impacts on infectious disease risk in Western Europe. Additionally, the survey explores the expert sample's prioritization of mitigation and adaptation, and expert views on the willingness and capacity of relevant actors to respond to climate change. An integrated view on the causation of infectious disease risk is employed, including multiple (climatic and non-climatic) factors. The results show that the experts consider some adaptation responses as relatively more cost-effective, like fostering interagency and community partnerships, or beneficial to health, such as outbreak investigation and response. Expert opinions converge and diverge for different adaptation responses. Regarding the prioritization of mitigation and adaptation responses expert perspectives converge towards a 50/50 budgetary allocation. The experts consider the national government/health authority as the most capable actor to respond to climate change-induced infectious disease risk. Divergence and consensus among expert opinions can influence adaptation policy processes. Further research is necessary to uncover prevailing expert perspectives and their roots, and compare these.

  17. Climate Change and Infectious Disease Risk in Western Europe: A Survey of Dutch Expert Opinion on Adaptation Responses and Actors

    PubMed Central

    Akin, Su-Mia; Martens, Pim; Huynen, Maud M.T.E.

    2015-01-01

    There is growing evidence of climate change affecting infectious disease risk in Western Europe. The call for effective adaptation to this challenge becomes increasingly stronger. This paper presents the results of a survey exploring Dutch expert perspectives on adaptation responses to climate change impacts on infectious disease risk in Western Europe. Additionally, the survey explores the expert sample’s prioritization of mitigation and adaptation, and expert views on the willingness and capacity of relevant actors to respond to climate change. An integrated view on the causation of infectious disease risk is employed, including multiple (climatic and non-climatic) factors. The results show that the experts consider some adaptation responses as relatively more cost-effective, like fostering interagency and community partnerships, or beneficial to health, such as outbreak investigation and response. Expert opinions converge and diverge for different adaptation responses. Regarding the prioritization of mitigation and adaptation responses expert perspectives converge towards a 50/50 budgetary allocation. The experts consider the national government/health authority as the most capable actor to respond to climate change-induced infectious disease risk. Divergence and consensus among expert opinions can influence adaptation policy processes. Further research is necessary to uncover prevailing expert perspectives and their roots, and compare these. PMID:26295247

  18. Attitudes and Opinions from the Nation's High Achieving Teens. 25th Annual Survey of High Achievers.

    ERIC Educational Resources Information Center

    Who's Who among American High School Students, Lake Forest, IL.

    This survey was conducted during the spring of 1994 for the purpose of determining the attitudes of student leaders in the nation's high schools. Eight thousand surveys were sent out to students, of which 3177 were returned. All students surveyed were members of the junior or senior class during the 1993-94 academic year. They were selected for…

  19. Attitudes and Opinions from the Nation's High Achieving Teens. 24th Annual Survey of High Achievers.

    ERIC Educational Resources Information Center

    Who's Who among American High School Students, Lake Forest, IL.

    This survey represents information compiled by the largest national survey of adolescent leaders and high achievers. Of the 5,000 students selected demographically from "Who's Who Among American High School Students," 1,957 responded. All students surveyed had "A" or "B" averages, and 98% planned on attending college. Questions were asked about…

  20. Nutritional and microbial analysis of bully sticks and survey of opinions about pet treats.

    PubMed

    Freeman, Lisa M; Janecko, Nicol; Weese, J Scott

    2013-01-01

    The objectives of this study were to measure the caloric density of bully sticks, to analyze the bully sticks for bacterial contamination, and to assess owner opinions about these and other pet treat products. Mean caloric density was 15 kcal/inch (38 kcal/cm) [range: 9 to 22 kcal/inch (23 to 56 kcal/cm), 2.96 to 3.07 kcal/g]. Of 26 bully sticks that were tested for bacterial contamination 1 (4%) was contaminated with Clostridium difficile, 1 was contaminated with methicillin-resistant Staphylococcus aureus (MRSA), and 1 with a tetracycline resistant Escherichia coli.

  1. A Survey On Spine Surgeons’ Opinions On The Release Of The Centers for Medicare and Medicaid Services Data

    PubMed Central

    Koerner, John D.; Shah, Anuj; Arnold, Paul M.; Isaacs, Robert E.; Hilibrand, Alan S.; Vaccaro, Alexander R.; Radcliff, Kristen E.

    2015-01-01

    Background In April 2014 the Centers for Medicare and Medicaid Services (CMS) released a dataset for the public which included information on services provided by physicians and healthcare providers for Medicare beneficiaries in the 2012 calendar year. The objective of this study is to determine spine surgeons’ opinions on the release of the CMS data, and determine how they feel this information may affect patient care. Methods A survey was sent to members of the Association for Collaborative Spine Research (ACSR) regarding their practice patterns and opinions on the release of the CMS data. Determinants included surgical subspecialty, practice setting, years in practice and region. The average response was collected for each question and compared across groups. Additionally, questions in which greater than 75% of respondents either agreed (agree or strongly agree) or disagreed (disagree or strongly disagree) were identified. Results Seventy-six surgeons completed the survey, and while the overall interobserver reliability between each question was only slight (κ = 0.11), more than 75% of respondents either agreed or strongly agreed with five statements and, more than 75% of respondents either disagreed or strongly disagreed with six statements. While 86% of surgeons are in favor of more transparency, 83% of respondents felt that without the proper context, the data released does not accurately portray spine surgery. Additionally, 96% of spine surgeons do not believe the CMS data helps patients decide which spine surgeon is best for them. Conclusions The small percentage of spine surgeons who responded to this survey are in favor of more transparency but do not feel the release of the CMS data either accurately represents spine surgeons or will help patients better identify the appropriate surgeon. In spite of these concerns, it is unlikely the release of the CMS data will significantly impact the accessibility of a spine surgeon to a Medicare beneficiary. PMID

  2. High Achievers: 23rd Annual Survey. Attitudes and Opinions from the Nation's High Achieving Teens.

    ERIC Educational Resources Information Center

    Who's Who among American High School Students, Northbrook, IL.

    This report presents data from an annual survey of high school student leaders and high achievers. It is noted that of the nearly 700,000 high achievers featured in this edition, 5,000 students were sent the survey and 2,092 questionnaires were completed. Subjects were high school juniors and seniors selected for recognition by their principals or…

  3. A Preliminary Survey of Professional and Student Opinion of Special Education Practice in Contemporary Russia.

    ERIC Educational Resources Information Center

    Agran, Martin; Boykov, Dmitriy

    2003-01-01

    A survey of 27 Russian students and educators enrolled in a defectology course found that most respondents were knowledgeable of and supported inclusion practices advocated in the United States and Western Europe, although belief in traditional practices of segregation of individuals with disabilities was also evident. The survey also addressed…

  4. Attitudes and Opinions from the Nation's High Achieving Teens. 18th Annual Survey of High Achievers.

    ERIC Educational Resources Information Center

    Educational Communications, Inc., Lake Forest, IL.

    This document contains factsheets and news releases which cite findings from a national survey of 1,985 high achieving high school students. Factsheets describe the Who's Who Among American High School Students recognition and service program for high school students and explain the Who's Who survey. A summary report of this eighteenth annual…

  5. [A survey on the use of patent expired drugs in psychiatric disorders: the psychiatrists' and neurologists' opinion and competence].

    PubMed

    Bersani, Giuseppe

    2015-01-01

    The use of generic drugs is an increasing phenomenon in Italy, as well as in most other Countries. In front of this, the level of information of medical doctors about their characteristics is still frequently uncompletely defined and insufficiently documented. The Survey "InfoMind" explored by an on line questionnaire the level of knowledge and the principal modes of use of generic drugs in a wide group of Italian Psychiatrists and Neurologists. The attention was focused on the use of generic drugs both in general and in the field of antidepressant treatments. In the group of participants (246) who fulfilled the questionnaire, a valid degree of attention to the critical issues related to the use of generic drugs and a variable level of information with respect to the explored areas were found. Main topics of discordant opinions were those of the pharmacokinetic differences among generic and original drugs, the related potential influence on clinical response, the regulatory rules on production and quality control of generic drugs respect to original. The main issues emerged as critical also respect the use of antidepressant drugs. Also the opinions regarding the legal implications of the choice of prescribed drugs appear variable and of the greatest interest.

  6. Opinions on Kampo and reasons for using it – results from a cross-sectional survey in three Japanese clinics

    PubMed Central

    2013-01-01

    Background Traditional Japanese Medicine (Kampo) is often used in Japan, but very little data on its users are available. We investigated who uses Kampo, the reasons and opinions for its use. Methods Questionnaire survey in three Japanese outpatient clinics offering Kampo in different settings: Kampo only, Kampo and traditional Chinese medicine, Kampo and Western medicine. Before seeing the doctor, patients were asked about socio-demographic data, medical history, experience with Kampo, general health-related opinions and behaviours, opinions about Western medicine and Kampo, and reasons for Kampo utilization. Descriptive statistics and predictors for Kampo use were calculated. Results A total of 354 questionnaires were completed. Participants were 50.97 ± 15.60 (mean ± SD) years of age, 68% were female. Of all patients, 73% (n = 202) were using Kampo currently and 84% (297) had taken Kampo before. Questions on general health-related opinions and behaviour revealed a strong environmental awareness. The most frequent indications for earlier Kampo use were: common cold (36%), gastrointestinal complaints (30%), oversensitivity to cold (“Hi’e-sho”; 29%), stress/anxiety (21%), and shoulder stiffness (20%). Kampo users suffered more often from chronic illnesses (OR 2.88 [1.48-5.58]). Beliefs in underlying philosophy (Wu Xing (adjusted OR 3.08, [1.11-8.55]), Ying and Yang (OR 2.57 [1.15-5.73], a holistic way of seeing the patient (OR 2.17 [1.53-3.08]), and in Kampo efficacy (OR 2.62 [1.66-4.13]) were positively associated with Kampo use. So was, interestingly, conviction of the efficacy of Western medicine (OR 1.87 [1.28-2.74]). Half of the patients had a general preference for a combination of Kampo and Western treatment. Conclusions Most patients visiting a clinic that also provided Kampo had previous experience with Kampo. Usage was associated with beliefs in philosophical Kampo concepts and its efficacy. PMID:23680097

  7. Targeting improved patient outcomes using innovative product listing agreements: a survey of Canadian and international key opinion leaders

    PubMed Central

    Thompson, Melissa; Henshall, Chris; Garrison, Louis P; Griffin, Adrian D; Coyle, Doug; Long, Stephen; Khayat, Zayna A; Anger, Dana L; Yu, Rebecca

    2016-01-01

    Objectives To address the uncertainty associated with procuring pharmaceutical products, product listing agreements (PLAs) are increasingly being used to support responsible funding decisions in Canada and elsewhere. These agreements typically involve financial-based rebating initiatives or, less frequently, outcome-based contracts. A qualitative survey was conducted to improve the understanding of outcome-based and more innovative PLAs (IPLAs) based on input from Canadian and international key opinion leaders in the areas of drug manufacturing and reimbursement. Methods Results from a structured literature review were used to inform survey development. Potential participants were invited via email to partake in the survey, which was conducted over phone or in person. Responses were compiled anonymously for review and reporting. Results Twenty-one individuals participated in the survey, including health technology assessment (HTA) key opinion leaders (38%), pharmaceutical industry chief executive officers/vice presidents (29%), ex-payers (19%), and current payers/drug plan managers/HTA (14%). The participants suggested that ~80%–95% of Canadian PLAs are financial-based rather than outcomes-based. They indicated that IPLAs offer important benefits to patients, payers, and manufacturers; however, several challenges limit their use (eg, administrative burden, lack of agreed-upon endpoint). They noted that IPLAs are useful in rapidly evolving therapeutic areas and those associated with high unmet need, a quantifiable endpoint, and/or robust data systems. The Canadian Agency for Drugs and Technologies in Health, the pan-Canadian Pharmaceutical Alliance, and other arms-length organizations could play important roles in identifying uncertainty and endpoints and brokering pan-Canadian PLAs. Industry should work collaboratively with payers to identify uncertainty and develop innovative mechanisms to address it. Conclusion The survey results indicated that while

  8. Ordering Diagnostic Imaging: A Survey of Ontario Physiotherapists' Opinions on an Expanded Scope of Practice

    PubMed Central

    Chong, Jodie Ng Fuk; De Luca, Krista; Goldan, Sana; Imam, Abdullah; Li, Boris; Zabjek, Karl; Chu, Anna

    2015-01-01

    ABSTRACT Purpose: To explore Ontario physiotherapists' opinions on their ability to order diagnostic imaging (DI). Methods: An online questionnaire was sent to all registered members of the College of Physiotherapists of Ontario. Descriptive statistics were calculated using response frequencies. Practice characteristics were compared using χ2 tests and Wilcoxon rank–sum tests. Results: Of 1,574 respondents (21% response rate), 42% practised in orthopaedics and 53% in the public sector. Most physiotherapists were interested in ordering DI (72% MRI/diagnostic ultrasound, 78% X-rays/computed tomography scans). Respondents with an orthopaedic caseload of 50% or more (p<0.001) and those in the private sector (p<0.001) were more interested in ordering DI. Respondents preferred a DI course that combined face-to-face and Web-based components and one that was specific to their area of practice. Most respondents perceived minimal barriers to the uptake of ordering DI, and most agreed that support from other health care professionals would facilitate uptake. Conclusion: The majority of Ontario physiotherapists are interested in ordering DI. For successful implementation of a health care change, such as physiotherapists' ability to order DI, educational needs and barriers to and facilitators of the uptake of the authorized activity should be considered. PMID:25931666

  9. Communicating Chemical Risks for Social Learning: Findings from an Expert Opinion Survey

    ERIC Educational Resources Information Center

    Lyytimaki, Jari; Assmuth, Timo; Hilden, Mikael

    2009-01-01

    Environmental and health risks caused by chemical substances have been intensively debated in various arenas of science and policy, and in news media. The impacts of risk debates on the public have been widely studied, while less attention has been paid to expert views. We present results from a cross-national survey charting expert views on the…

  10. 12th Annual Survey of High Achievers: Attitudes and Opinions from the Nation's Outstanding Teen Leaders.

    ERIC Educational Resources Information Center

    Who's Who among American High School Students, Northbrook, IL.

    The report, fact sheets, and news releases cite findings of a survey involving 22,000 Ss to determine the attitudes of high school student leaders. Responses were tabulated for the following areas: demographics, government mandates/taxes, American institutions, domestic issues, foreign issues/defense, religious beliefs/practices, marriage/sex,…

  11. Attitudes and Opinions from the Nation's High Achieving Teens: 26th Annual Survey of High Achievers.

    ERIC Educational Resources Information Center

    Who's Who among American High School Students, Lake Forest, IL.

    A national survey of 3,351 high achieving high school students (junior and senior level) was conducted. All students had A or B averages. Topics covered include lifestyles, political beliefs, violence and entertainment, education, cheating, school violence, sexual violence and date rape, peer pressure, popularity, suicide, drugs and alcohol,…

  12. Attitudes and Opinions from the Nation's High Achieving Teens: 29th Annual Survey of High Achievers.

    ERIC Educational Resources Information Center

    Who's Who among American High School Students, Lake Forest, IL.

    This report presents the 1998 statistical findings of the annual survey to determine the attitudes of national high school student leaders. Questionnaires were completed by 3,123 high school juniors and seniors, all of whom were selected for recognition in "Who's Who among American High School Students." In addition to demographic…

  13. Attitudes and Opinions from the Nation's High Achieving Teens: 28th Annual Survey of High Achievers.

    ERIC Educational Resources Information Center

    Who's Who among American High School Students, Lake Forest, IL.

    This report details the 28th annual study to examine the attitudes of student leaders in U.S. high schools. Participating in the survey were 3,210 adolescents, primarily 16- and 17-year-olds, who had been featured in the 1997 edition of "Who's Who Among American High School Students." The report presents demographic information on the…

  14. Academic Libraries, Facebook and MySpace, and Student Outreach: A Survey of Student Opinion

    ERIC Educational Resources Information Center

    Connell, Ruth Sara

    2009-01-01

    This study surveyed 366 Valparaiso University freshmen to discover their feelings about librarians using Facebook and MySpace as outreach tools. The vast majority of respondents had online social network profiles. Most indicated that they would be accepting of library contact through those Web sites, but a sizable minority reacted negatively to…

  15. "Is This Ethical?" A Survey of Opinion on Principles and Practices of Document Design.

    ERIC Educational Resources Information Center

    Dragga, Sam

    1996-01-01

    Reprints a corrected version of an article originally published in the volume 43, number 1 issue of this journal. Presents results of a national survey of technical communicators and technical communication teachers assessing the ethics of seven document design cases involving manipulation of typography, illustrations, and photographs. Offers…

  16. 22nd Annual Survey of High Achievers: Attitudes and Opinions from the Nation's High Achieving Teens.

    ERIC Educational Resources Information Center

    Who's Who among American High School Students, Northbrook, IL.

    This study surveyed high school students (N=1,879) who were student leaders or high achievers in the spring of 1991 for the purpose of determining their attitudes. Students were members of the junior or senior high school class during the 1990-91 academic year and were selected for recognition by their principals or guidance counselors, other…

  17. Who's Who among American High School Students: Tenth National Opinion Survey.

    ERIC Educational Resources Information Center

    Education Communications, Inc., Northbrook, IL.

    Attitudes of student leaders in high schools throughout the United States were examined in a survey conducted by Who's Who Among American High School Students and Northbrook, Illinois. Subjects were students who had been selected for inclusion in Who's Who during the 1978-79 academic year. Some 23,200 completed questionnaires were analyzed on…

  18. Attitudes and Opinions from the Nation's High Achieving Teens: 27th Annual Survey of High Achievers.

    ERIC Educational Resources Information Center

    Who's Who among American High School Students, Lake Forest, IL.

    This report details the 27th annual study to examine the attitudes of student leaders in U.S. high schools. Participating in the survey were 3,370 adolescents, primarily 16- and 17-year-olds, who had been featured in the 1996 edition of "Who's Who Among American High School Students." The report presents demographic information on the survey…

  19. The Metropolitan Life Survey of the American Teacher, 1996. Students Voice Their Opinions On: Violence, Social Tension and Equality among Teens. Part I

    ERIC Educational Resources Information Center

    Metropolitan Life Insurance Company, 1996

    1996-01-01

    This report, the first in a series of four 1996 releases of students' opinions, represents a continued effort by MetLife to provide insight and understanding to the issues of violence and social tension in American public schools. The survey focuses on the social climate of the nation's public schools from the perspective of public school students…

  20. The Touche Ross Survey of Business Executives on Non-Profit Boards. An Opinion Study Based on Interviews with 309 Business Executives.

    ERIC Educational Resources Information Center

    Research and Forecasts, Inc., New York, NY.

    Three hundred eight business executives from boards of nonprofit educational, social service, or cultural organizations were surveyed for their opinions on their roles. It was found that a single overriding concern is the ever-increasing demand for commitment and accountability. This is reflected particularly in three issues: time, money, and…

  1. Teenager Views on Issues Related to Traffic Safety Education and the Licensing of Teenage Drivers: Results of a Statewide Opinion Survey on Washington Teenage Drivers. Final Report.

    ERIC Educational Resources Information Center

    Bloomfield, Gary J.; Kinch, Robert

    In Washington, the existence of driver education programs is being threatened by tough economic times. To determine the opinions of teenage drivers about their traffic safety education (TSE) experience, the process of learning to drive, and the licensing of 16- and 17-year-olds, 10 percent of TSE students (N=1,070) were surveyed. Further data were…

  2. Attitudes and Beliefs About Domestic Violence: Results of a Public Opinion Survey. I. Definitions of Domestic Violence, Criminal Domestic Violence, and Prevalence

    ERIC Educational Resources Information Center

    Carlson, Bonnie E.; Worden, Alissa Pollitz

    2005-01-01

    This study reports analyses and findings from a public opinion survey designed to explore beliefs about domestic violence (DV) -- what it is, when it is against the law, and how prevalent it is. The project interviewed 1,200 residents from six New York communities. The analyses reveal substantial first hand and second hand experience with DV and…

  3. Pharmacy Staff Opinions Regarding Diabetic Retinopathy Screenings in the Community Setting: Findings from a Brief Survey

    PubMed Central

    Law, Miranda G.; Komura, Stephanie; Murchison, Ann P.; Pizzi, Laura T.

    2013-01-01

    Background Diabetic retinopathy is a retinal vascular disorder that affects more than 4.1 million people in the United States. New methods of detecting and ensuring adequate follow-up of this life-altering disease are vital to improving patient outcomes. Wills Eye Hospital and the Centers for Disease Control and Prevention are conducting a collaborative study to initiate a novel diabetic retinopathy screening in the community setting. Objective To evaluate the feasibility of a more widespread, large-scale implementation of this novel model of care for diabetic retinopathy screening in the community setting. Methods A simple, self-administered survey was distributed to pharmacists, pharmacy technicians, student pharmacists, and Wills Eye Hospital interns. The survey consisted of open-ended questions and responders were given 1 week to respond. A total of 22 surveys were distributed and 16 were completed. The responses were culled and analyzed to assess the feasibility of implementing this novel screening model in the pharmacy. Results The response rate to this pilot survey was 72%. The majority of the responding pharmacy staff members indicated that diabetic retinopathy screening in community pharmacies would greatly benefit patients and could improve patient care. However, they also noted barriers to implementing the screening, such as concerns about the cost of carrying out the screenings, the cost of the equipment needed to be purchased, and the lack of time and shortage of pharmacy staff. Conclusion The potential exists for pharmacists to positively influence diabetes care by implementing retinopathy care through the early detection of the disease and reinforcement of the need for follow-up; however, real-world barriers must be addressed before widespread adoption of such a novel model of care becomes feasible. PMID:24991381

  4. The potential Public Health Impact of Mycobacterium avium ssp. paratuberculosis: Global Opinion Survey of Topic Specialists.

    PubMed

    Waddell, L A; Rajić, A; Stärk, K D C; McEwen, S A

    2016-05-01

    Global research knowledge has accumulated over the past few decades, and there is reasonable evidence for a positive association between Mycobacterium avium spp. paratuberculosis and Crohn's disease in humans, although its role as a human pathogen has not been entirely accepted. For this reason, management of public health risk due to M. paratuberculosis remains an important policy issue in agri-food public health arenas in many countries. Responsible authorities must decide whether existing mitigation strategies are sufficient to prevent or reduce human exposure to M. paratuberculosis. A Web-based questionnaire was administered to topic specialists to elicit empirical knowledge and opinion on the overall public health impact of M. paratuberculosis, the importance of various routes of human exposure to the pathogen, existing mitigation strategies and the need for future strategies. The questionnaire had four sections and consisted of 20 closed and five open questions. Topic specialists believed that M. paratuberculosis is likely a risk to human health (44.8%) and, given the paucity of available evidence, most frequently ranked it as a moderate public health issue (40.1%). A significant correlation was detected between topic specialists' commitment to M. paratuberculosis in terms of the number of years or proportion of work dedicated to this topic, and the likelihood of an extreme answer (high or low) to the above questions. Topic specialists identified contact with ruminants and dairy products as the most likely routes of exposure for humans. There was consensus on exposure routes for ruminants and what commodities to target in mitigation efforts. Described mandatory programmes mainly focused on culling diseased animals and voluntary on-farm prevention programmes. Despite ongoing difficulties in the identification of subclinical infections in animals, the topic specialists largely agreed that further enhancement of on-farm programmes in affected commodities by

  5. Genetically Modified (GM) Mosquito Use to Reduce Mosquito-Transmitted Disease in the US: A Community Opinion Survey

    PubMed Central

    Adalja, Amesh; Sell, Tara Kirk; McGinty, Meghan; Boddie, Crystal

    2016-01-01

    Introduction: Mosquito-borne infectious diseases such as dengue, chikungunya, and now Zika, pose a public health threat to the US, particularly Florida, the Gulf Coast states, and Hawaii. Recent autochthonous transmission of dengue and chikungunya in Florida, the recent dengue outbreak in Hawaii, and the potential for future local spread of Zika in the US, has led to the consideration of novel approaches to mosquito management. One such novel approach, the release of sterile genetically modified mosquitoes, has been proposed as a possible intervention, and a trial release of GM mosquitoes is being considered in one Florida community. However, this proposal has been controversial. The objective of this research was to increase understanding of community knowledge, attitudes, and beliefs regarding mosquito control and GM mosquitoes.   Methods: An 18-question self-administered survey was mailed to all households in the identified Key West, Florida neighborhood where a GM mosquito trial has been proposed. This survey was fielded between July 20, 2015 and November 1, 2015. The main outcome variable was opposition to the use of GM mosquitoes. Measures included demographic information and opinions on mosquitoes, mosquito control, and vector-borne diseases.   Results: A majority of survey respondents did not support use of GM mosquitoes as a mosquito control method. Discussion: Reasons for opposition included general fears about possible harmful impacts of this intervention, specific worries about human and animal health impacts from the GM mosquitoes, and environmental concerns about potential negative effects on the ecosystem. Residents were more likely to oppose GM mosquito use if they had a low perception of the potential risks posed by diseases like dengue and chikungunya, if they were female, and if they were less concerned about the need to control mosquitoes in general. These findings suggest a need for new approaches to risk communication, including

  6. Prevailing Opinions on Connected Health in Austria: Results from an Online Survey

    PubMed Central

    Haluza, Daniela; Naszay, Marlene; Stockinger, Andreas; Jungwirth, David

    2016-01-01

    New technological developments affect almost every sector of our daily lives, including the healthcare sector. We evaluated how connected health applications, subsumed as eHealth and telemedicine, are perceived in relation to socio-demographic characteristics. The current cross-sectional, online survey collected self-reported data from a non-probability convenience sample of 562 Austrian adults (58.9% females). The concept of eHealth and telemedicine was poorly established among the study population. While most participants already used mobile devices, they expressed a quite low desirability of using various telemedicine applications in the future. Study participants perceived that the most important overall benefits for implementing connected health technology were better quality of healthcare, location-independent access to healthcare services, and better quality of life. The respective three top-ranked overall barriers were data security, lack of acceptance by doctors, and lack of technical prerequisites. With regard to aging societies, healthcare providers, and users alike could take advantage of inexpensive, consumer-oriented connected health solutions that address individual needs of specific target groups. The present survey identified issues relevant for successful implementation of ICT-based healthcare solutions, providing a compilation of several areas requiring further in-depth research. PMID:27529261

  7. [Opinion survey about purchasing nonprescription drugs over the internet in remote islands--survey among internet-literate inhabitants].

    PubMed

    Hirayama, Tadahiko; Tanaka, Hidekazu; Suzuki, Shintarou; O-mura, Heiji; Nagase, Masayoshi; Sakumoto, Seiji; Sugahara, Masanori; Kitahara, Toshihiro; Miyazaki, Cho-Ichiro; Yamashita, Noboru; Yoshitani, Kiyomitu; Miki, Akiko; Satoh, Hiroki; Hori, Satoko; Sawada, Yasufumi

    2011-01-01

    The revised Pharmaceutical Affairs Act that came into force in June 2009 prohibits the sales of nonprescription drugs by mail. However, as a provisional measure, regular users and inhabitants of remote islands that do not have pharmacies or drug stores would be able to purchase nonprescription drugs by mail for two years. However, this regulation is now being discussed from the perspectives of safety and convenience. The purpose of this study was to conduct a survey on the purchasing of nonprescription drugs over the Internet by inhabitants of remote islands belonging to Goto City in Nagasaki prefecture. The results showed that approximately 78.0% of the Internet-literate respondents living on large islands (with pharmacies, drug stores, and pharmacists, e.g., Fukue-shima), 65.4% of the Internet-literate respondents living on small islands scattered around large islands (where pharmacies, drug stores, and pharmacists are not located, e.g., Mae-shima) had purchased necessities except nonprescription drugs, but the rate of purchasing nonprescription drugs over the Internet was approximately less than 10%. The results of this survey suggest that it is not necessary to purchase nonprescription drugs over the Internet. However, owing to a small but significant minority of inhabitants who need to purchase nonprescription drugs over the Internet, there is an urgent need for establishing an optimum system for supplying medicinal products to remote islands.

  8. The cost of medicines in the United Kingdom. A survey of general practitioners' opinions and knowledge.

    PubMed

    Silcock, J; Ryan, M; Bond, C M; Taylor, R J

    1997-01-01

    Prescribing costs in general practice continue to grow. Their importance is underlined by the amount of information concerned with costs that general practitioners (GPs) receive, and by the existence of target budgets. In 1986 and 1991, surveys showed that GPs agreed that cost should be borne in mind when choosing medicines, but that their knowledge of drug prices was often inaccurate. This study assessed the current knowledge and attitudes of GPs in the UK in respect of prescribing costs, and examined the influence of various developments in general practice since 1986 on the accuracy of drug price estimation. 1000 randomly selected GP principals (500 in Scotland and 125 in each of 4 English health regions) were sent a postal questionnaire. The GPs' level of agreement with 5 statements concerned with prescribing costs, and the accuracy of their estimates of the basic price of 31 drugs, were analysed. Most GPs (71%) agreed that prescribing costs should be taken into account when deciding on the best treatment for patients. Fundholders were more likely than non-fundholders: (i) to agree that prescribing costs could be reduced without affecting patient care; (ii) to agree that providing more information on costs would lower the cost of prescribing; and (iii) to comment that cost guidelines had changed their prescribing habits. Fundholders were less likely than non-fundholders to reject the principle of fixed limits on prescribing costs. Overall, one-third of the price estimates given were accurate (within 25% of the actual cost). For the most expensive drugs in the survey [those priced over 10 pounds sterling (Pound) per pack], half of the price estimates were accurate. There were significant differences between non-fundholders' and fundholders' estimates of the price of less expensive drugs (those priced at less than 10 pounds per pack). Use of a formulary or computer-displayed drug price information did not affect the accuracy of price estimates. It may be that GPs

  9. Survey of doctors' opinions of the legalisation of physician assisted suicide

    PubMed Central

    Lee, William; Price, Annabel; Rayner, Lauren; Hotopf, Matthew

    2009-01-01

    Background Assisted dying has wide support among the general population but there is evidence that those providing care for the dying may be less supportive. Senior doctors would be involved in implementing the proposed change in the law. We aimed to measure support for legalising physician assisted dying in a representative sample of senior doctors in England and Wales, and to assess any association between doctors' characteristics and level of support for a change in the law. Methods We conducted a postal survey of 1000 consultants and general practitioners randomly selected from a commercially available database. The main outcome of interest was level of agreement with any change in the law to allow physician assisted suicide. Results The corrected participation rate was 50%. We analysed 372 questionnaires. Respondents' views were divided: 39% were in favour of a change to the law to allow assisted suicide, 49% opposed a change and 12% neither agreed nor disagreed. Doctors who reported caring for the dying were less likely to support a change in the law. Religious belief was also associated with opposition. Gender, specialty and years in post had no significant effect. Conclusion More senior doctors in England and Wales oppose any step towards the legalisation of assisted dying than support this. Doctors who care for the dying were more opposed. This has implications for the ease of implementation of recently proposed legislation. PMID:19261197

  10. Nurses' expert opinions of workplace interventions for a healthy working environment: a Delphi survey.

    PubMed

    Doran, Diane; Clarke, Sean; Hayes, Laureen; Nincic, Vera

    2014-09-01

    Much has been written about interventions to improve the nursing work environment, yet little is known about their effectiveness. A Delphi survey of nurse experts was conducted to explore perceptions about workplace interventions in terms of feasibility and likelihood of positive impact on nurse outcomes such as job satisfaction and nurse retention. The interventions that received the highest ratings for likelihood of positive impact included: bedside handover to improve communication at shift report and promote patient-centred care; training program for nurses in dealing with violent or aggressive behaviour; development of charge nurse leadership team; training program focused on creating peer-supportive atmospheres and group cohesion; and schedule that recognizes work balance and family demands. The overall findings are consistent with the literature that highlights the importance of communication and teamwork, nurse health and safety, staffing and scheduling practices, professional development and leadership and mentorship. Nursing researchers and decision-makers should work in collaboration to implement and evaluate interventions for promoting practice environments characterized by effective communication and teamwork, professional growth and adequate support for the health and well-being of nurses.

  11. Familiarity, opinions, experiences and knowledge about scalp cooling: a Dutch survey among breast cancer patients and oncological professionals

    PubMed Central

    Peerbooms, Mijke; van den Hurk, Corina JG; Breed, Wim PM

    2015-01-01

    Objective: Scalp cooling (SC) is applied to reduce chemotherapy-induced alopecia (CIA). The aim of this study was to investigate patients’ familiarity and opinions and oncological professionals’ attitude and knowledge about SC in the Netherlands. Methods: Ex breast cancer patients, nurses and medical oncologists (MDs) from SC and non-SC hospitals filled out questionnaires. Results: The majority of MDs and nurses were satisfied with the results of SC, as were SC patients. Over 33% of MDs and nurses perceived their knowledge level insufficient to inform patients about effectiveness, which was over 43% for information about safety. MDs main reason to not apply SC was doubt about effectiveness and safety. Nurses generally offered SC to a minority of eligible patients. Patients were frequently unfamiliar with SC before diagnosis. Seventy percent of SC patients with insufficient results (20/52) reported to mind it very much. With expected success rates of 35% and 50%, respectively, 36% and 54% of patients would use SC again. Conclusion: Room for improvement has been shown for both patients’ familiarity and oncological professionals’ knowledge about SC. Sharing knowledge about results, safety and patients’ experiences will improve patient counseling and SC availability. The results of this survey led to the development of a national standard on CIA and SC. PMID:27981090

  12. Stigma and Public Support for Insurance Parity and Government Spending on Mental Health: Findings from a 2013 National Opinion Survey

    PubMed Central

    Barry, Colleen L; McGinty, Emma Elizabeth

    2015-01-01

    Objective The goal of this study is to gauge current attitudes among Americans about policies to: (1) require insurance parity for mental health, drug and alcohol abuse benefits and (2) increase government spending on mental health treatment. Methods A web-based public opinion survey (N=1,517) was conducted with a national sample of Americans, and examined how respondents’ socio-economic characteristics, political predispositions, personal experience, and attitudes toward persons with mental illness were associated with policy support. Results Sixty-nine percent of Americans supported insurance parity and 59 percent supported increasing government spending on mental health. Democrats were more supportive than Republicans or Independents. Personal experience was associated with higher support, and those expressing stigma in their attitudes toward persons with mental illness were less supportive of both policies. Conclusions Most Americans favored policies to expand insurance and funding for mental health treatment, but stigma was associated with lower support for both policies. This finding reinforces the importance developing robust anti-stigma efforts, particularly in an era when mental illness is increasingly linked to dangerousness in news media portrayals. PMID:25270496

  13. Current and future perspectives on lumbar degenerative disc disease: a UK survey exploring specialist multidisciplinary clinical opinion

    PubMed Central

    McGregor, Alison H

    2016-01-01

    Objectives Despite lumbar degenerative disc disease (LDDD) being significantly associated with non-specific low back pain and effective treatment remaining elusive, specialist multidisciplinary clinical stakeholder opinion remains unexplored. The present study examines the views of such experts. Design A reliable and valid electronic survey was designed to establish trends using theoretical constructs relating to current assessment and management practices. Clinicians from the Society of Back Pain Research (SBPR) UK were invited to take part. Quantitative data were collated and coded using Bristol Online Surveys (BOS) software, and content analysis was used to systematically code and categorise qualitative data. Setting Specialist multidisciplinary spinal interest group in the UK. Participants 38/141 clinically active, multidisciplinary SBPR members with specialist spinal interest participated. Among them, 84% had >9 years postgraduate clinical experience. Interventions None. Outcome measures Frequency distributions were used to establish general trends in quantitative data. Qualitative responses were coded and categorised in relation to each theme and percentage responses were calculated. Results LDDD symptom recurrence, in the absence of psychosocial influence, was associated with physical signs of joint stiffness (26%), weakness (17%) and joint hypermobility (6%), while physical factors (21%) and the ability to adapt (11%) were postulated as reasons why some experience pain and others do not. No one management strategy was supported exclusively or with consensus. Regarding effective modalities, there was no significant difference between allied health professional and medic responses (p=0.1–0.8). The future of LDDD care was expressed in terms of improvements in patient communication (35%), patient education (38%) and treatment stratification (24%). Conclusions Results suggest that multidisciplinary expert spinal clinicians appear to follow UK

  14. The opinion of clinical staff regarding painfulness of procedures in pediatric hematology-oncology: an Italian survey

    PubMed Central

    2011-01-01

    Background Beliefs of caregivers about patient's pain have been shown to influence assessment and treatment of children's pain, now considered an essential part of cancer treatment. Painful procedures in hematology-oncology are frequently referred by children as the most painful experiences during illness. Aim of this study was to evaluate professionals' beliefs about painfulness of invasive procedures repeatedly performed in Pediatric Hemato-Oncology Units. Methods Physicians, nurses, psychologists and directors working in Hemato-Oncology Units of the Italian Association of Pediatric Hematology-Oncology (AIEOP) were involved in a wide-nation survey. The survey was based on an anonymous questionnaire investigating beliefs of operators about painfulness of invasive procedures (lumbar puncture, bone marrow aspirate and bone marrow biopsy) and level of pain management. Results Twenty-four directors, 120 physicians, 248 nurses and 22 psychologists responded to the questionnaire. The score assigned to the procedural pain on a 0-10 scale was higher than 5 in 77% of the operators for lumbar puncture, 97.5% for bone marrow aspiration, and 99.5% for bone marrow biopsy. The scores assigned by nurses differed statistically from those of the physicians and directors for the pain caused by lumbar puncture and bone marrow aspiration. Measures adopted for procedural pain control were generally considered good. Conclusions Invasive diagnostic-therapeutic procedures performed in Italian Pediatric Hemato-Oncology Units are considered painful by all the caregivers involved. Pain management is generally considered good. Aprioristically opinions about pain depend on invasiveness of the procedure and on the professional role. PMID:21663631

  15. Results of the 2004 Knowledge and Opinions Surveys for the Baseline Knowledge Assessment of the U.S. Department of Energy Hydrogen Program

    SciTech Connect

    Schmoyer, Richard L; Truett, Lorena Faith; Cooper, Christy

    2006-04-01

    The U.S. Department of Energy (DOE) Hydrogen Program focuses on overcoming critical barriers to the widespread use of hydrogen fuel cell technology. The transition to a new, hydrogen-based energy economy requires an educated human infrastructure. With this in mind, the DOE Hydrogen Program conducted statistical surveys to measure and establish baselines for understanding and awareness about hydrogen, fuel cells, and a hydrogen economy. The baseline data will serve as a reference in designing an education program, and it will be used in comparisons with future survey results (2008 and 2011) to measure changes in understanding and awareness. Scientific sampling was used to survey four populations: (1) the general public, ages 18 and over; (2) students, ages 12-17; (3) state and local government officials; and (4) potential large-scale hydrogen users. It was decided that the survey design should include about 1,000 individuals in each of the general public and student categories, about 250 state and local officials, and almost 100 large-scale end users. The survey questions were designed to accomplish specific objectives. Technical questions measured technical understanding and awareness of hydrogen technology. Opinion questions measured attitudes about safety, cost, the environment, and convenience, as well as the likelihood of future applications of hydrogen technology. For most of the questions, "I don't know" or "I have no opinion" were acceptable answers. Questions about information sources assessed how energy technology information is received. The General Public and Student Survey samples were selected by random digit dialing. Potential large-scale end users were selected by random sampling. The State and Local Government Survey was of the entire targeted population of government officials (not a random sample). All four surveys were administered by computer-assisted telephone interviewing (CATI). For each population, the length of the survey was less than 15

  16. A survey of first-year biology student opinions regarding live lectures and recorded lectures as learning tools.

    PubMed

    Simcock, D C; Chua, W H; Hekman, M; Levin, M T; Brown, S

    2017-03-01

    A cohort of first-year biology students was surveyed regarding their opinions and viewing habits for live and recorded lectures. Most respondents (87%) attended live lectures as a rule (attenders), with 66% attending more than two-thirds of the lectures. In contrast, only 52% accessed recordings and only 13% viewed more than two-thirds of the available recordings. Respondents regarded lectures as efficient for information delivery (75%), and 89% enjoyed live lectures because they were useful for learning (89%), understanding coursework (94%), and keeping up with the subject (93%). Lecture enjoyment was driven less by entertainment (34%) or interaction with the lecturers (47%), although most students preferred an entertaining lecturer to a factual expert (72%). Exam marks were positively correlated with the number of lectures attended (P < 0.001) and negatively correlated with the number of recordings viewed (P < 0.05), although marks were similar for lecture attenders and nonattenders (P > 0.05). Lecture attenders mostly missed lectures to complete assessments during the same week (68%), whereas nonattenders were more likely to miss lectures due to outside commitments or preference for study from books or recorded lectures (P < 0.001). Recordings were used to replace missed lectures (64%), rather than for revision, and were viewed mostly alone (96%) in one sitting (65%). Only 22% of respondents agreed that some lectures could be replaced by recordings, but 59% agreed with having some videoconference lectures from experts on another campus. Overall, this cohort showed a clear preference for live lectures over recordings, with limited support for synchronous videoconference lectures.

  17. A survey of UK prescribers' experience of, and opinions on, anthelmintic prescribing practices for livestock and equines.

    PubMed

    Easton, Stephanie; Pinchbeck, Gina L; Bartley, David J; Hotchkiss, Emily; Hodgkinson, Jane E; Matthews, Jacqueline B

    2016-11-01

    The aim of this study was to determine practices, attitudes and experiences of UK prescribers of anthelmintics for horses and livestock. A questionnaire was sent by direct email to groups licenced to prescribe these medicines. These were veterinarians, Suitably Qualified Persons (SQPs, registered with the Animal Medicines Training Regulatory Authority) and veterinary pharmacists. The survey was also advertised through social media. It comprised questions relating to demographics, training experiences, current prescribing practices, as well as personal opinions on anthelmintic selection, diagnostics and anthelmintic resistance. A total of 193 veterinarians and 326 SQPs were included in final analysis. Pharmacists were excluded from detailed analysis due to the low numbers that responded (n=3). The results indicated that SQP participants were more likely to receive post-certification parasitology training than the veterinarians, and that both channels consulted similar sources for information about helminths and their control (paper articles in journals, online sources). The SQP participants stated a higher frequency of face-to-face interactions with clients/customers (96.1%) than the veterinarians (76.4%), who stated a higher frequency of telephone interactions (55.1% and 73.5%, respectively). Veterinarians were more likely to state that there were specific factors that limited interactions with their clients (54.1%) than SQPs (19.6%), such as competition from other suppliers. SQP participants considered a wider range of factors as important when deciding on which anthelmintic to recommend (i.e. knowledge of specific parasites, knowledge of specific anthelmintics, discussion of measures to avoid anthelmintic resistance and time to talk with clients/customers); however, the veterinarian participants were more likely to consider the results of diagnostic tests. While discussions about anthelmintic resistance were stated with similar frequency in both groups, less

  18. Chemotherapy drug handling in first opinion small animal veterinary practices in the United Kingdom: results of a questionnaire survey.

    PubMed

    Edery, E G

    2017-03-07

    To investigate how first opinion small animal veterinary surgeons in the UK handled chemotherapeutic agents, a questionnaire was distributed at the 2014 British Small Animal Veterinary Association congress and by internet. Chemotherapy was regularly offered by 70.4 per cent of the respondents. Gold standards defined according to available guidelines for safe handling of antineoplastic drugs were poorly followed by general practitioners with only 2 per cent of respondents complying with all of them. Dedicated facilities for preparation and administration of cytotoxic drugs were variably available among participants. The level of training of staff indirectly involved in handling chemotherapy was appropriate in less than 50 per cent of practices. No association was found between demographic characteristics of the sampled population and the decision to perform chemotherapy. The results of this study raise concerns about the safety of the veterinary staff in first opinion practices involved in handling chemotherapy.

  19. Opinion: Mycopedagogy

    ERIC Educational Resources Information Center

    Dworkin, Craig

    2004-01-01

    A teacher at the university of Utah describes his opinion by citing examples of experimental, innovative, avant-garde, a number of literary traditions adopted in college classrooms. The advantages and the dangers of these being pedagogy are explained.

  20. Personalised, predictive and preventive medication process in hospitals—still rather missing: professional opinion survey on medication safety in Czech hospitals (based on professional opinions of recognised Czech health care experts)

    PubMed Central

    2014-01-01

    The survey had the following aims: (1) to rationalise the hypothesis that risks and losses relating to medication process' errors in Czech hospitals are at least comparable with the other developed countries and EU countries especially, (2) to get a valid professional opinion/estimate on the rate of adverse drug events happening in Czech hospitals, (3) to point out that medication errors represent real and serious risks and (4) to induce the hospital management readiness to execute fundamental changes and improvements to medication processes. We read through a lot of studies inquiring into hospitals' medication safety. Then, we selected the studies which brought reliable findings and formulated credible conclusions. Finally, we addressed reputable Czech experts in health care and asked them structured questions whether the studies' findings and conclusions corresponded with our respondents' own experience in the Czech hospital clinical practice and what their own estimates of adverse drug events' consequences were like. Based on the reputable Czech health care expert opinions/estimates, the rate of a false drug administration may exceed 5%, and over 7% of those cause serious health complications to Czech hospital inpatients. Measured by an average length of stay (ALOS), the Czech inpatients, harmed by a false drug administration, stay in hospital for more than 2.6 days longer than necessary. Any positive changes to a currently used, traditional, ways of drug dispensing and administration, along with computerisation, automation, electronic traceability, validation, or verification, must well pay off. Referring to the above results, it seems to be wise to follow the EU priorities in health and health care improvements. Thus, a right usage of the financial means provided by the EC—in terms of its new health programmes for the period 2014–2020 (e.g. Horizon 2020)—has a good chance of a good result in doing the right things right, at the right time and in the

  1. A School Staff Opinion Survey Predicts Student Achievement in Victoria, Australia: Evidence from a Structural Equation Modeling Analysis

    ERIC Educational Resources Information Center

    Clark, Tedra F.; Goddard, Roger

    2016-01-01

    Effective school reform requires communication with and buy-in from key stakeholders. In recent years, stakeholder surveys have become increasingly prominent tools for promoting better understanding of how school factors contribute to student success. The key purpose of this study was to investigate the relation between Victorian school scores on…

  2. Using the Opinions and Lifestyle Survey to Examine the Prevalence and Characteristics of Families Who Home Educate in the UK

    ERIC Educational Resources Information Center

    Smith, Emma; Nelson, Jeanette

    2015-01-01

    This paper has two aims, first to examine the feasibility of using an omnibus survey to estimate the prevalence and characteristics of families who home educate and secondly to provide an empirical contribution to recent research on home education in the UK. Because there is no statutory requirement for families who home educate to register with…

  3. Landmark opinions

    SciTech Connect

    Julian Levy

    2007-08-15

    On April 2, 2007, the U.S. Supreme Court issued two landmark opinions affecting the regulation of air quality in the United States. The first addressed one facet of what constitutes a modification under New Source Review (NSR) and the second addressed the issue of global climate change, specifically carbon dioxide emissions. For this month's issue, EM invited five leaders in the field of air quality to give their perspectives on these court opinions to gauge what they might mean for future air quality regulations. Titles of the five features are: Two landmark interpretations of the Clean Air Act: EPA authority to regulate greenhouse gases and increases in annual emissions trigger NSR (pp 6-10); Court examines EPA's interpretation of the Clean Air Act (pp 11,13); New Jersey: a state's perspective (pp 14-15); Supreme Court delivers historic environmental rulings (pp 17-18); and an industry perspective on the Supreme Court rulings (pp 20-21).

  4. A review of brain-computer interface games and an opinion survey from researchers, developers and users.

    PubMed

    Ahn, Minkyu; Lee, Mijin; Choi, Jinyoung; Jun, Sung Chan

    2014-08-11

    In recent years, research on Brain-Computer Interface (BCI) technology for healthy users has attracted considerable interest, and BCI games are especially popular. This study reviews the current status of, and describes future directions, in the field of BCI games. To this end, we conducted a literature search and found that BCI control paradigms using electroencephalographic signals (motor imagery, P300, steady state visual evoked potential and passive approach reading mental state) have been the primary focus of research. We also conducted a survey of nearly three hundred participants that included researchers, game developers and users around the world. From this survey, we found that all three groups (researchers, developers and users) agreed on the significant influence and applicability of BCI and BCI games, and they all selected prostheses, rehabilitation and games as the most promising BCI applications. User and developer groups tended to give low priority to passive BCI and the whole head sensor array. Developers gave higher priorities to "the easiness of playing" and the "development platform" as important elements for BCI games and the market. Based on our assessment, we discuss the critical point at which BCI games will be able to progress from their current stage to widespread marketing to consumers. In conclusion, we propose three critical elements important for expansion of the BCI game market: standards, gameplay and appropriate integration.

  5. A Review of Brain-Computer Interface Games and an Opinion Survey from Researchers, Developers and Users

    PubMed Central

    Ahn, Minkyu; Lee, Mijin; Choi, Jinyoung; Jun, Sung Chan

    2014-01-01

    In recent years, research on Brain-Computer Interface (BCI) technology for healthy users has attracted considerable interest, and BCI games are especially popular. This study reviews the current status of, and describes future directions, in the field of BCI games. To this end, we conducted a literature search and found that BCI control paradigms using electroencephalographic signals (motor imagery, P300, steady state visual evoked potential and passive approach reading mental state) have been the primary focus of research. We also conducted a survey of nearly three hundred participants that included researchers, game developers and users around the world. From this survey, we found that all three groups (researchers, developers and users) agreed on the significant influence and applicability of BCI and BCI games, and they all selected prostheses, rehabilitation and games as the most promising BCI applications. User and developer groups tended to give low priority to passive BCI and the whole head sensor array. Developers gave higher priorities to “the easiness of playing” and the “development platform” as important elements for BCI games and the market. Based on our assessment, we discuss the critical point at which BCI games will be able to progress from their current stage to widespread marketing to consumers. In conclusion, we propose three critical elements important for expansion of the BCI game market: standards, gameplay and appropriate integration. PMID:25116904

  6. Results of the 2008/2009 Knowledge and Opinions Surveys Conducted for the U.S. Department of Energy Hydrogen Program

    SciTech Connect

    Schmoyer, Richard L; Truett, Lorena Faith; Cooper, Christy; Chew, Andrea

    2010-04-01

    The U.S. Department of Energy (DOE) Fuel Cell Technologies Program (FCT) conducts comprehensive efforts to enable the widespread commercialization of fuel cells in diverse sectors of the economy - with emphasis on applications that will most effectively strengthen our nation's energy security and improve our stewardship of the environment. Expanding the use of fuel cells requires a sustained education effort to lay the foundation for future commercial market introduction. The FCT education subprogram seeks to facilitate fuel cell demonstrations and support future commercialization by providing technically accurate and objective information to key target audiences both directly and indirectly involved in the use of fuel cells today. These key target audiences include a public that is familiar and comfortable with using a new fuel, state and local government officials who understand the near-term realities and long-term potential of the technology, an educated business and industry component, and trained safety and codes officials. With this in mind, the DOE FCT program established an education key activity to address the training and informational needs of target audiences that have a role in the near-term transition and the long-term development of a hydrogen economy. Whether or not changes can be attributed to the program, designing and maintaining an effective education program entails measuring baseline awareness and periodically measuring what has been learned. The purpose of this report is to document the data and results of statistical surveys undertaken in 2008 and 2009 to measure and establish changes in understanding and awareness about hydrogen and fuel cell technologies since a baseline survey was conducted in 2004. This report is essentially a data book, a digest of the survey data and an exposition of changes in knowledge of and opinions about hydrogen and fuel cell technology since 2004. Many conclusions can be made from the survey data. However, the

  7. A survey of Italian physicians' opinion about stem cells research: what doctors prefer and what the law requires.

    PubMed

    Frati, Paola; Gulino, Matteo; Pacchiarotti, Arianna; D'Errico, Stefano; Sicuro, Lorella; Fineschi, Vittorio

    2014-01-01

    To evaluate the Italian physicians' knowledge/information level about the therapeutic potential of stem cells, the research choice between embryonic and cordonal stem cells, and the preference between autologous and heterologous storage of cordonal stem cells, we performed a national survey. The questionnaire--distributed to 3361 physicians--involved physicians of different religious orientations and of different medical specialities. Most of the physicians involved (67%) were Catholics, and the majority were gynaecologists and paediatricians (43%) who are mainly in charge to inform future mothers about the possibility of cordonal stem cells conservation. The majority of the physicians interviewed do not have specific knowledge about stem cells (59%), most of them having only generic information (92%). The largest part of physicians prefer to use umbilical cord blood cells rather than embryonic stem cells. Nevertheless, a large percentage of physicians were in favour of embryo research, especially when embryos are supernumerary (44% versus 34%). Eighty-seven % of the physicians interviewed proved to have a general knowledge about stem cells and believe in their therapeutic potential. They prefer research on cordonal stem cells rather than on embryo stem cells. Although they are in favour of heterologous stem cells donation, they still prefer cryopreservation for personal use.

  8. Opinions on Dental Erosive Lesions, Knowledge of Diagnosis, and Treatment Strategies among Norwegian Dentists: A Questionnaire Survey

    PubMed Central

    Mulic, Aida; Vidnes-Kopperud, Simen; Skaare, Anne B.; Tveit, Anne Bjørg; Young, Alix

    2012-01-01

    This study aimed to investigate dentists' general experience, knowledge about diagnosis, and treatment of dental erosive wear in young adults. A questionnaire was sent to 1262 Norwegian public dental health-employed dentists. The response rate was 60%. Results indicated that most dentists recorded erosive wear, half of them used a specific scoring system, and half registered lesions at the tooth surface level. Lesions were reported most often on palatal surfaces of upper anterior teeth (79% of dentists), on occlusal surfaces of lower 1st molars (74%), and on upper 1st molars (32%). Half the dentists used clinical photographs for documentation and 60% made study models. While 40% reported more erosive lesions in males, 36% reported no gender differences. High intake of carbonated beverages and acidic juices were reported as the most common cause by 97% and 72% of the dentists, respectively. Only 21% of dentists recorded the patient's dietary history, and 73% never measured saliva secretion. The majority (78%) of the dentists treated patients with erosive wear themselves. In general, the survey suggests that the dentists are relatively up to date regarding the clinical recording, diagnosis, and treatment of dental erosive wear. However, dietary and salivary analyses were not given priority, and early, preventive treatment was lacking. PMID:22927855

  9. Absorption of CIS Immigrants into Israeli Schools: A Semipermeable Enclave Model.

    ERIC Educational Resources Information Center

    Resnik, Julia; Sabar, Naama; Shoham, Edna; Shapira, Rina

    2001-01-01

    Examined how immigrants from the Commonwealth of Independent States (CIS) assimilated into Israeli society and schools. Data from observations, interviews, and surveys indicated that educational policies and school arrangements, and CIS immigrants' high self-esteem, produced a semipermeable enclave. CIS students acquired the Hebrew language and…

  10. Environment and Public Opinion in Minnesota.

    ERIC Educational Resources Information Center

    Tichenor, P. J.; And Others

    Surveys conducted in Minnesota in 1969 and 1970 to obtain public opinion regarding environmental issues are discussed. Several generalizations are made about the state of public opinion about the environmental issue, as follows: (1) The environmental issue has reached public prominence through a sequence from professional and interest-group…

  11. Public Opinion Poll Question Databases: An Evaluation

    ERIC Educational Resources Information Center

    Woods, Stephen

    2007-01-01

    This paper evaluates five polling resource: iPOLL, Polling the Nations, Gallup Brain, Public Opinion Poll Question Database, and Polls and Surveys. Content was evaluated on disclosure standards from major polling organizations, scope on a model for public opinion polls, and presentation on a flow chart discussing search limitations and usability.

  12. Opinion Survey -- Revision and Validation

    DTIC Science & Technology

    1993-04-01

    34When authority is seen to be absolute... it leads to extreme cognitive distinctions between persons as faithful and unfaithful , orthodox and heretical...cites example of these factors: unrelated habits, beliefs, power needs, ego motives and the need to allay anxiety , etc. He specifically cites Lhe

  13. Recent trends in the management of Graves' hyperthyroidism in Japan: opinion survey results, especially on the combination therapy of antithyroid drug and thyroid hormone.

    PubMed

    Mori, T; Sugawa, H; Kosugi, S; Ueda, M; Hai, N; Matsuda, A

    1997-08-01

    An opinion survey concerning the management of Graves' hyperthyroidism was conducted among the council members of the Japan Thyroid Association. The selection of 3 major treatments by 90 respondents for their patients was 98.6 +/- 4.2% for antithyroid drug (ATD), 7.8 +/- 12.6% for partial thyroidectomy and 5.2 +/- 8.1% for radioiodide. They expressed a movement away from the past trend of surgery because of postoperative complications and unsatisfactory therapeutic results, and they assumed a further reduction in the future. On the other hand, the frequency of radioiodide treatment was not considered to have decreased greatly, and they expected a slight increase in the future. Of the respondents, 65% suggested that hyperthyroidism should be completely cured even if the patient would fall into hypothyroidism. The major reasons for choosing surgery or radioiodide after ATD were the adverse effects of ATD and the age and social backgrounds of the patients. Large goiter size was the 3rd reason for surgery but was a minimal indicator for radioiodide. As for ATD treatment, none of the respondents reported the routine application of any uniform fixed-time therapy protocol. Japanese Graves' patients were shown to be less responsive to ATD than Caucasian patients. This was assumed to result at least from high iodide intake, and half of them had ordered their patients to restrict iodide intake. Furthermore, 78% of them had treated with a combined therapy of ATD and thyroid hormone. Most of them apply this for selected patients mainly to lower TSH receptor antibody activity, to better control their patients and to reduce the goiter size. All but 8 (9%) did not give T4 (or T3) after the cessation of ATD, and they felt this to be unnecessary, doubtful about the effect, unsuitable or even possible to induce recurrence. The excellent findings reported by Hashizume et al. (N Engl J Med 324: 947-953, 1991) are well known among them. However, most of them did not agree with the

  14. University Opinion Poll 8A: Bicycles on Campus.

    ERIC Educational Resources Information Center

    Matross, Ronald; And Others

    The University Opinion Poll conducted a two-stage survey of campus bicycle usage and opinions toward campus bicycle facilities. In the first stage, 952 persons, 78% of a random sample of students and staff reported their commuting habits and opinions about campus bicycle lanes. In the second stage, 139 persons, 84% of a sample of student and staff…

  15. cis-1,2-Dichloroethylene

    Integrated Risk Information System (IRIS)

    EPA / 635 / R - 09 / 006 F www.epa.gov / iris TOXICOLOGICAL REVIEW OF cis - 1,2 - DICHLOROETHYLENE and trans - 1,2 - DICHLOROETHYLENE ( CAS Nos . cis : 156 - 59 - 2 ; trans : 156 - 60 - 5 ; mixture : 540 - 59 - 0 ) In Support of Summary Information on the Integrated Risk Information System ( IRIS )

  16. Public Opinion in America.

    ERIC Educational Resources Information Center

    Monroe, Alan D.

    The purposes of this book are to summarize and analyze the nature of public opinion in contemporary America and to examine the implications of that nature for the possibility of a functioning democracy. Material in the four sections covers the following topics: "The Study of Public Opinion: Political Theory and Methodology"--opinions and…

  17. Opinion Integration and Summarization

    ERIC Educational Resources Information Center

    Lu, Yue

    2011-01-01

    As Web 2.0 applications become increasingly popular, more and more people express their opinions on the Web in various ways in real time. Such wide coverage of topics and abundance of users make the Web an extremely valuable source for mining people's opinions about all kinds of topics. However, since the opinions are usually expressed as…

  18. The Davis Social Environment-1990: A Report of Student Opinions.

    ERIC Educational Resources Information Center

    Low, Jane M.

    A study was done to examine student opinion of the social environment on the University of California Davis campus in Spring 1990 as a follow up to a similar study conducted in 1987. The study used the Student Opinion Survey and mailed it to a stratified random sample of 1,649 students. Of the surveys sent, 57.7 percent were returned. The…

  19. Results of the 2008/2009 Knowledge and Opinions Surveys Conducted for the U.S. Department of Energy Hydrogen Program

    SciTech Connect

    Schmoyer, R. L.; Truett, Tykey; Cooper, Christy; Chew, Andrea

    2010-04-01

    This report presents results of a 2008/2009 survey of hydrogen and fuel cell awareness conducted for the U.S. Department of Energy (DOE). The 2008/2009 survey follows up on a similar DOE survey conducted in 2004, measuring levels of awareness and understanding of hydrogen and fuel cell technologies in four populations: (1) the general public, (2) students, (3) personnel in state and local governments, and (4) potential end users of hydrogen and fuel cell technologies in business and industry. The 2008/2009 survey includes these four groups and adds a fifth group, safety and code officials. The same survey methods were used for both surveys; the 2008/2009 survey report includes a comparison of 2004 and 2008/2009 findings. Information from these surveys will be used to enhance hydrogen and fuel cell education strategies.

  20. Evidence-Based Practice: a survey regarding behavior, knowledge, skills, resources, opinions and perceived barriers of Brazilian physical therapists from São Paulo state

    PubMed Central

    Silva, Tatiane M.; Costa, Lucíola C. M.; Costa, Leonardo O. P.

    2015-01-01

    BACKGROUND: Evidence-Based Practice (EBP) has been widely used by health professionals. However, no study in Brazil has investigated the data regarding the knowledge and difficulties related to EBP from a representative sample of physical therapists. OBJECTIVE: To identify behavior, knowledge, skills, resources, opinions and perceived barriers of Brazilian physical therapists from the state of São Paulo regarding EBP. METHOD: A customized questionnaire about behavior, knowledge, skills, resources, opinions and perceived barriers regarding EBP was sent by email to a sample of 490 physical therapists registered by the Registration Board of São Paulo, Brazil. Physical therapists who did not respond to the questionnaire were contacted by telephone and/or letter. The data were analyzed descriptively. RESULTS: The final response rate was 64.4% (316/490). Because 60 physical therapists were no longer practicing, 256 answers were analyzed. The physical therapists reported that they routinely read scientific papers (89.5%) as a resource for professional development, followed by continuing education courses (88.3%) and books (86.3%). Approximately 35% of the respondents reported a clear understanding of the implementation of research findings in their practice; approximately 37% reported no difficulties in critically appraising scientific papers; and 67.2% strongly agreed that EBP is important for their practice. The most commonly reported barriers were related to difficulties in obtaining full-text papers (80.1%), using EBP may represent higher cost (80.1%) and the language of publication of the papers (70.3%). CONCLUSION: Physical therapists from São Paulo state believe that they have knowledge and skills to use EBP. Although they have favorable opinions regarding its implementation, they still encounter difficulties in implementing EBP successfully. PMID:26443977

  1. Survival of extreme opinions

    NASA Astrophysics Data System (ADS)

    Hsu, Jiann-wien; Huang, Ding-wei

    2009-12-01

    We study the survival of extreme opinions in various processes of consensus formation. All the opinions are treated equally and subjected to the same rules of changing. We investigate three typical models to reach a consensus in each case: (A) personal influence, (B) influence from surroundings, and (C) influence to surroundings. Starting with uniformly distributed random opinions, our calculated results show that the extreme opinions can survive in both models (A) and (B), but not in model (C). We obtain a conclusion that both personal influence and passive adaptation to the environment are not sufficient enough to eradicate all the extreme opinions. Only the active persuasion to change the surroundings eliminates the extreme opinions completely.

  2. Vibrational overtone spectrum of matrix isolated cis, cis-HOONO.

    PubMed

    Zhang, Xu; Nimlos, Mark R; Ellison, G Barney; Varner, Mychel E; Stanton, John F

    2007-05-07

    Cis, cis-peroxynitrous acid is known to be an intermediate in atmospheric reactions between OH and NO2 as well as HOO and NO. The infrared absorption spectra of matrix-isolated cc-HOONO and cc-DOONO in argon have been observed in the range of 500-8000 cm-1. Besides the seven fundamental vibrational modes that have been assigned earlier for this molecule [Zhang et al., J. Chem. Phys. 124, 084305 (2006)], more than 50 of the overtone and combination bands have been observed for cc-HOONO and cc-DOONO. Ab initio CCSD(T)/atomic natural orbital anharmonic force field calculations were used to help guide the assignments. Based on this study of the vibrational overtone transitions of cis, cis-HOONO that go as high as 8000 cm-1 and the earlier paper on the vibrational fundamentals, we conclude that the CCSD(T)/ANO anharmonic frequencies seem to correct to +/-35 cm-1. The success of the theoretically predicted anharmonic frequencies {upsilon} in assigning overtone spectra of HOONO up to 8000 cm-1 suggests that the CCSD(T)/ANO method is producing a reliable potential energy surface for this reactive molecule.

  3. [Opinions of Brazilian physicians on artificial fertilization from the ethics point of view].

    PubMed

    Meira, A R; Martins, A M

    1993-10-01

    An ethical opinion survey was carried out among Brazilian physicians regarding artificial insemination. The results showed no statistical difference between opinions of physicians from the various regions of the country.

  4. Polymorphism of linoleic acid (cis-9, cis-12-octadecadienoic acid) and alpha-linolenic acid (cis-9, cis-12, cis-15-octadecatrienoic acid).

    PubMed

    Ueno, S; Miyazaki, A; Yano, J; Furukawa, Y; Suzuki, M; Sato, K

    2000-10-01

    Crystallization and polymorphic properties of linoleic acid (cis-9, cis-12-Octadecadienoic acid) (LA) and alpha-linolenic acid (cis-9, cis-12, cis-15-Octadecatrienoic acid) (alpha-LNA) have been studied by optical microscopy, differential scanning calorimetry (DSC) and X-ray diffraction (XRD). The DSC analyses presented three polymorphs in LA, and two polymorphs in alpha-LNA. The XRD patterns of the higher- and lower-temperature forms in LA and alpha-LNA showed orthorhombic O'(//)+O-like and O'(//) subcell, which were similar to those of alpha- and gamma-forms of mono-unsaturated fatty acids, respectively. From the solvent crystallization of LA and alpha-LNA in acetonitrile, single crystals of the higher temperature polymorphs have been obtained. The crystal habits of truncated rhombic shape were also similar to those of alpha-forms of the mono-unsaturated fatty acids. The enthalpy and entropy values of fusion and dissolution of the alpha-forms of LA, alpha-LNA and oleic acid showed that the two values decreased with increasing number of the cis-double bond.

  5. Nigerian lawyers and reproductive health rights: a survey of knowledge, practices and opinions on law reforms among the bar and bench in north eastern Nigeria.

    PubMed

    Mairiga, Abdulkarim Garba; Geidam, Ado Dan'azumi; Bako, Babagana; Ibrahim, Abdullahi

    2012-03-01

    The objective of this study was to determine the knowledge and attitudes of practicing Nigerian lawyers towards issues relating to reproductive health and reproductive rights, and their opinions about abortion law reform. It was a population- based study which consisted of interviews with practicing lawyers in north-east Nigeria. The results showed poor knowledge of issues related to reproductive health and reproductive rights among the lawyers. However, the majority (56.9%) disagreed that a woman can practice family planning without the consent of her husband. The prevalence of contraceptive use among the lawyers was low and attitude to abortion law not satisfactory. Only few lawyers (22.4%) supported safe abortion in cases of failed contraception. We conclude that reproductive health advocates must target legal professionals with a view to educating them on issues relating to sexual and reproductive health and rights. Lawyers in Nigeria should undergo capacity building in reproductive health laws and be encouraged to specialize in reproductive rights protection as obtainable in other developed countries.

  6. Cis-Lunar Base Camp

    NASA Technical Reports Server (NTRS)

    Merrill, Raymond G.; Goodliff, Kandyce E.; Mazanek, Daniel D.; Reeves, John D., Jr.

    2012-01-01

    Historically, when mounting expeditions into uncharted territories, explorers have established strategically positioned base camps to pre-position required equipment and consumables. These base camps are secure, safe positions from which expeditions can depart when conditions are favorable, at which technology and operations can be tested and validated, and facilitate timely access to more robust facilities in the event of an emergency. For human exploration missions into deep space, cis-lunar space is well suited to serve as such a base camp. The outer regions of cis-lunar space, such as the Earth-Moon Lagrange points, lie near the edge of Earth s gravity well, allowing equipment and consumables to be aggregated with easy access to deep space and to the lunar surface, as well as more distant destinations, such as near-Earth Asteroids (NEAs) and Mars and its moons. Several approaches to utilizing a cis-lunar base camp for sustainable human exploration, as well as some possible future applications are identified. The primary objective of the analysis presented in this paper is to identify options, show the macro trends, and provide information that can be used as a basis for more detailed mission development. Compared within are the high-level performance and cost of 15 preliminary cis-lunar exploration campaigns that establish the capability to conduct crewed missions of up to one year in duration, and then aggregate mass in cis-lunar space to facilitate an expedition from Cis-Lunar Base Camp. Launch vehicles, chemical propulsion stages, and electric propulsion stages are discussed and parametric sizing values are used to create architectures of in-space transportation elements that extend the existing in-space supply chain to cis-lunar space. The transportation options to cis-lunar space assessed vary in efficiency by almost 50%; from 0.16 to 0.68 kg of cargo in cis-lunar space for every kilogram of mass in Low Earth Orbit (LEO). For the 15 cases, 5-year campaign

  7. The Development of a Community Survey To Measure Public Opinion Concerning the Implementation of a Continuous School Year Pilot Program, September-December 1973.

    ERIC Educational Resources Information Center

    Shafer, J. E.

    This report presents the results of a 1,044-person survey taken to determine public attitudes towards the concept of year-round schools in Guam. The study indicates the people of Guam will support a pilot 45-15 plan for two years in three elementary schools; and that variables such as sex, nationality, determination of leave schedules, and desire…

  8. Roles, Titles and Opinions of Selected State Extension Sheep Specialists, A Partial Summary of a Nationwide Survey. A Research Summary of a Graduate Study.

    ERIC Educational Resources Information Center

    Kazzal, Najeeb T.; And Others

    This survey-type study had the following purposes: (1) to consider the sheep and Extension sheep situation and trends in the nation; (2) to gather information regarding titles and duties of sheep specialists; (3) to collect copies of available job descriptions; and (4) to identify some reasons why sheep numbers have continued to decline.…

  9. Accountability for All: What Voters Want from Education Candidates. 2002 Public Education Network/"Education Week" National Survey of Public Opinion.

    ERIC Educational Resources Information Center

    Editorial Projects in Education, Bethesda, MD.

    This report presents information from a national survey commissioned in January 2002 by the Public Education Network and Education Week. The poll examines the attitudes of American voters towards public schools and reveals what they want politicians to do about education once they are in office. Overall, Americans assign great value to public…

  10. A Survey of U.S Adults’ Opinions about Conduct of a Nationwide Precision Medicine Initiative® Cohort Study of Genes and Environment

    PubMed Central

    Devaney, Stephanie

    2016-01-01

    Objectives A survey of a population-based sample of U.S adults was conducted to measure their attitudes about, and inform the design of the Precision Medicine Initiative’s planned national cohort study. Methods An online survey was conducted by GfK between May and June of 2015. The influence of different consent models on willingness to share data was examined by randomizing participants to one of eight consent scenarios. Results Of 4,777 people invited to take the survey, 2,706 responded and 2,601 (54% response rate) provided valid responses. Most respondents (79%) supported the proposed study, and 54% said they would definitely or probably participate if asked. Support for and willingness to participate in the study varied little among demographic groups; younger respondents, LGBT respondents, and those with more years of education were significantly more likely to take part if asked. The most important study incentive that the survey asked about was learning about one’s own health information. Willingness to share data and samples under broad, study-by-study, menu and dynamic consent models was similar when a statement about transparency was included in the consent scenarios. Respondents were generally interested in taking part in several governance functions of the cohort study. Conclusions A large majority of the U.S. adults who responded to the survey supported a large national cohort study. Levels of support for the study and willingness to participate were both consistent across most demographic groups. The opportunity to learn health information about one’s self from the study appears to be a strong motivation to participate. PMID:27532667

  11. University Opinion Poll 9: Child Care, MPIRG, Lettuce. Preliminary Report.

    ERIC Educational Resources Information Center

    Matross, Ronald; And Others

    The University Opinion Poll conducted a survey of student opinion on issues related to University-sponsored day care, the role of the Minnesota Public Interest Research Group (MPIRG) and the University's policy on buying lettuce for its food services. Four hundred fifty-two respondents, 76% of a random sample of University of Minnesota students,…

  12. Assigned Positions for In-Class Debates Influence Student Opinions

    ERIC Educational Resources Information Center

    Lilly, Emily

    2012-01-01

    In-class debates are frequently used to encourage student engagement. Ideally, after researching both sides of the debate, students will form their own opinions based on what they have learned. However, in a large course of Environmental Science, opinions of students, when surveyed after the debate, were remarkably consistent with the position…

  13. Psychiatric Opinion and Homosexuality: A Short Report

    ERIC Educational Resources Information Center

    Barr, R. F.; And Others

    1975-01-01

    In a survey of opinion among 100 psychiatrists and 93 trainees in Australia, the majority endorsed the view either that "homosexuality is a developmental anomaly not necessarily or commonly associated with neurotic symptoms" or that "homosexuality is a normal variant like left-handedness." (Author)

  14. Survey of expert opinions and related recommendations regarding bridging therapy using hypomethylating agents followed by allogeneic transplantation for high-risk MDS.

    PubMed

    Sohn, Sang Kyun; Moon, Joon Ho

    2015-08-01

    According to current guidelines on therapeutic strategies for myelodysplastic syndrome (MDS), cytoreductive therapies before allogeneic stem cell transplantation (SCT) are not widely recommended for patients with high-risk MDS or refractory anemia with excess blasts (RAEB) who are eligible for allogeneic SCT because of controversial evidence on the role of such therapies. Yet, while treatment with hypomethylating agents (HMAs) has a critical limitation in eradicating MDS clones, the use of HMA treatment as a bridge to allogeneic SCT has become a focus with the hope of improving the SCT outcome based on the chance of achieving complete remission or reducing the blast percentage safely and effectively before allogeneic SCT. However, a consensus needs to be established on the use of HMAs as a bridging therapy for high-risk MDS or RAEB. Thus, the Korean AML/MDS working party group surveyed 34 Korean MDS experts on their bridging therapies for high-risk MDS. Accordingly, this paper presents the survey questionnaire and resulting data, along with a summary of the consensus and related recommendations regarding strategies using HMA treatment and allogeneic SCT based on reported studies and the current survey results.

  15. The Importance of Bone Mineral Density in Hip Arthroplasty: Results of a Survey Asking Orthopaedic Surgeons about Their Opinions and Attitudes Concerning Osteoporosis and Hip Arthroplasty

    PubMed Central

    Kolbow, Kristina; Lazovic, Djordje; Maus, Uwe

    2016-01-01

    Objective. In patients scheduled to undergo total joint arthroplasty of the hip, the bone quality around the joint affects the safety of prosthetic implantation. Bone strength is clinically assessed by measuring bone mineral density (BMD); therefore we asked if BMD is important to orthopaedic surgeons performing hip arthroplasty. Methods. In a 14-question survey, we asked about treatment patterns with respect to BMD, osteoporosis work-up, and treatment for patients with low BMD scheduled to undergo hip arthroplasty. Results. 72% of all asked orthopaedics reported to use cementless implants as a standard in hip arthroplasty. Over 60% reported that low BMD is a reason to reconsider operation strategies, but only 4% performed BMD measurement preoperatively. 26% would change their treatment strategy in case of a BMD (T-Score) between −1.5 and −2 and 40% in case of a T-score between −2 and −2.5, and 29% would change their intraoperative strategy if a T-score smaller than −2.5 was measured. Conclusion. The majority of orthopaedic surgeons who responded to the survey reported that they do not perform routine measurement of BMD before arthroplasty. However, most surgeons commented that low bone mineral density will influence their surgical plan and the implant design. PMID:27999686

  16. Abundant raw material for cis-regulatory evolution in humans.

    PubMed

    Rockman, Matthew V; Wray, Gregory A

    2002-11-01

    Changes in gene expression and regulation--due in particular to the evolution of cis-regulatory DNA sequences--may underlie many evolutionary changes in phenotypes, yet little is known about the distribution of such variation in populations. We present in this study the first survey of experimentally validated functional cis-regulatory polymorphism. These data are derived from more than 140 polymorphisms involved in the regulation of 107 genes in Homo sapiens, the eukaryote species with the most available data. We find that functional cis-regulatory variation is widespread in the human genome and that the consequent variation in gene expression is twofold or greater for 63% of the genes surveyed. Transcription factor-DNA interactions are highly polymorphic, and regulatory interactions have been gained and lost within human populations. On average, humans are heterozygous at more functional cis-regulatory sites (>16,000) than at amino acid positions (<13,000), in part because of an overrepresentation among the former in multiallelic tandem repeat variation, especially (AC)(n) dinucleotide microsatellites. The role of microsatellites in gene expression variation may provide a larger store of heritable phenotypic variation, and a more rapid mutational input of such variation, than has been realized. Finally, we outline the distinctive consequences of cis-regulatory variation for the genotype-phenotype relationship, including ubiquitous epistasis and genotype-by-environment interactions, as well as underappreciated modes of pleiotropy and overdominance. Ordinary small-scale mutations contribute to pervasive variation in transcription rates and consequently to patterns of human phenotypic variation.

  17. Abundant raw material for cis-regulatory evolution in humans

    NASA Technical Reports Server (NTRS)

    Rockman, Matthew V.; Wray, Gregory A.

    2002-01-01

    Changes in gene expression and regulation--due in particular to the evolution of cis-regulatory DNA sequences--may underlie many evolutionary changes in phenotypes, yet little is known about the distribution of such variation in populations. We present in this study the first survey of experimentally validated functional cis-regulatory polymorphism. These data are derived from more than 140 polymorphisms involved in the regulation of 107 genes in Homo sapiens, the eukaryote species with the most available data. We find that functional cis-regulatory variation is widespread in the human genome and that the consequent variation in gene expression is twofold or greater for 63% of the genes surveyed. Transcription factor-DNA interactions are highly polymorphic, and regulatory interactions have been gained and lost within human populations. On average, humans are heterozygous at more functional cis-regulatory sites (>16,000) than at amino acid positions (<13,000), in part because of an overrepresentation among the former in multiallelic tandem repeat variation, especially (AC)(n) dinucleotide microsatellites. The role of microsatellites in gene expression variation may provide a larger store of heritable phenotypic variation, and a more rapid mutational input of such variation, than has been realized. Finally, we outline the distinctive consequences of cis-regulatory variation for the genotype-phenotype relationship, including ubiquitous epistasis and genotype-by-environment interactions, as well as underappreciated modes of pleiotropy and overdominance. Ordinary small-scale mutations contribute to pervasive variation in transcription rates and consequently to patterns of human phenotypic variation.

  18. Recycling Of Cis Photovoltaic Waste

    DOEpatents

    Drinkard, Jr., William F.; Long, Mark O.; Goozner; Robert E.

    1998-07-14

    A method for extracting and reclaiming metals from scrap CIS photovoltaic cells and associated photovoltaic manufacturing waste by leaching the waste with dilute nitric acid, skimming any plastic material from the top of the leaching solution, separating glass substrate from the leachate, electrolyzing the leachate to plate a copper and selenium metal mixture onto a first cathode, replacing the cathode with a second cathode, re-electrolyzing the leachate to plate cadmium onto the second cathode, separating the copper from selenium, and evaporating the depleted leachate to yield a zinc and indium containing solid.

  19. Advanced research on cis-Neonicotinoids.

    PubMed

    Shao, Xusheng; Ye, Zhejun; Bao, Haibo; Liu, Zewen; Xu, Xiaoyong; Li, Zhong; Qian, Xuhong

    2011-01-01

    cis-Neonicotinoids are a type of neonicotinoid, in which the nitro or the cyano group are in cis-configuration relative to heteroaromatic moiety, which show excellent activities against a range of insect species. This review covers cis-neonicotinoids with commercialization perspectives, structural optimization (phenylazoneonicotinoids and chlorothiazolyl analogues of Paichongding), modes of action studies, radiao-synthesis of Paichongding and Cycloxaprid, and photostability of neonicotinoids.

  20. Anisotropic opinion dynamics

    NASA Astrophysics Data System (ADS)

    Neirotti, Juan

    2016-07-01

    We consider the process of opinion formation in a society of interacting agents, where there is a set B of socially accepted rules. In this scenario, we observed that agents, represented by simple feed-forward, adaptive neural networks, may have a conservative attitude (mostly in agreement with B ) or liberal attitude (mostly in agreement with neighboring agents) depending on how much their opinions are influenced by their peers. The topology of the network representing the interaction of the society's members is determined by a graph, where the agents' properties are defined over the vertexes and the interagent interactions are defined over the bonds. The adaptability of the agents allows us to model the formation of opinions as an online learning process, where agents learn continuously as new information becomes available to the whole society (online learning). Through the application of statistical mechanics techniques we deduced a set of differential equations describing the dynamics of the system. We observed that by slowly varying the average peer influence in such a way that the agents attitude changes from conservative to liberal and back, the average social opinion develops a hysteresis cycle. Such hysteretic behavior disappears when the variance of the social influence distribution is large enough. In all the cases studied, the change from conservative to liberal behavior is characterized by the emergence of conservative clusters, i.e., a closed knitted set of society members that follow a leader who agrees with the social status quo when the rule B is challenged.

  1. Anisotropic opinion dynamics.

    PubMed

    Neirotti, Juan

    2016-07-01

    We consider the process of opinion formation in a society of interacting agents, where there is a set B of socially accepted rules. In this scenario, we observed that agents, represented by simple feed-forward, adaptive neural networks, may have a conservative attitude (mostly in agreement with B) or liberal attitude (mostly in agreement with neighboring agents) depending on how much their opinions are influenced by their peers. The topology of the network representing the interaction of the society's members is determined by a graph, where the agents' properties are defined over the vertexes and the interagent interactions are defined over the bonds. The adaptability of the agents allows us to model the formation of opinions as an online learning process, where agents learn continuously as new information becomes available to the whole society (online learning). Through the application of statistical mechanics techniques we deduced a set of differential equations describing the dynamics of the system. We observed that by slowly varying the average peer influence in such a way that the agents attitude changes from conservative to liberal and back, the average social opinion develops a hysteresis cycle. Such hysteretic behavior disappears when the variance of the social influence distribution is large enough. In all the cases studied, the change from conservative to liberal behavior is characterized by the emergence of conservative clusters, i.e., a closed knitted set of society members that follow a leader who agrees with the social status quo when the rule B is challenged.

  2. Readership Surveys Build Confidence.

    ERIC Educational Resources Information Center

    Bohle, Bob

    1980-01-01

    Reports results of a survey of students' opinions of their school newspaper. Lists four changes that were based on the survey results: (1) added emphasis on meeting students' personal interest needs, (2) increase in short feature and humorous stories, (3) more persuasive editorial and opinion pieces, and (4) increase in advertising benefits for…

  3. West European public opinion on security: a comparative analysis

    SciTech Connect

    Brown, R.M.

    1985-01-01

    This dissertation empirically explored the security opinion formation process within the British, French, and West Germany populations. Basic theory assumed two sources of security opinion. First, the actions and official statements of political elites furnish strong but transient influence in forming public attitudes, which, in turn, are a basis for opinions. Second, attributes predispose individuals to adopt attitudes, and thus opinions. The influence of attributes is less forceful than are elite cues, but attributes give some stability to opinion - attributes being immutable or slow to change. The analysis of the influence of attributes and attitudes on opinion was based on results of 1976-1982 public opinion surveys. The findings both supported the assumptions on the opinion forming roles of attributes and elite cues and addressed related issues of current interest. The probable security predisposition of the contemporary West European successor generation, an altered role for Europeans holding post material values, and the functional - as opposed to geographic - nature of the supranationalist attitude were among major topics addressed. The dissertation ends with a prediction on mid-term stability and change in the role and functioning of the Atlantic alliance.

  4. Public opinion factors regarding nuclear power

    SciTech Connect

    Benson, B.

    1991-12-31

    This paper is an effort to identify, as comprehensively as possible, public concerns about nuclear power, and to assess, where possible, the relative importance of these concerns as they relate to government regulation of and policy towards nuclear power. It is based on some two dozen in-depth interviews with key communicators representing the nuclear power industry, the environmental community, and government, as well as on the parallel efforts in our research project: (1) review of federal court case law, (2) a selective examination of the Nuclear Regulatory Commission (NRC) administrative process, and (3) the preceding George Mason University research project in this series. The paper synthesizes our findings about public attitudes towards nuclear power as expressed through federal court case law, NRC administrative law, public opinion surveys, and direct personal interviews. In so doing, we describe the public opinion environment in which the nuclear regulatory process must operate. Our premise is that public opinion ultimately underlies the approaches government agencies take towards regulating nuclear power, and that, to the degree that the nuclear power industry`s practices are aligned with public opinion, a more favorable regulatory climate is possible.

  5. Public opinion factors regarding nuclear power

    SciTech Connect

    Benson, B.

    1991-01-01

    This paper is an effort to identify, as comprehensively as possible, public concerns about nuclear power, and to assess, where possible, the relative importance of these concerns as they relate to government regulation of and policy towards nuclear power. It is based on some two dozen in-depth interviews with key communicators representing the nuclear power industry, the environmental community, and government, as well as on the parallel efforts in our research project: (1) review of federal court case law, (2) a selective examination of the Nuclear Regulatory Commission (NRC) administrative process, and (3) the preceding George Mason University research project in this series. The paper synthesizes our findings about public attitudes towards nuclear power as expressed through federal court case law, NRC administrative law, public opinion surveys, and direct personal interviews. In so doing, we describe the public opinion environment in which the nuclear regulatory process must operate. Our premise is that public opinion ultimately underlies the approaches government agencies take towards regulating nuclear power, and that, to the degree that the nuclear power industry's practices are aligned with public opinion, a more favorable regulatory climate is possible.

  6. Plant growth inhibition by cis-cinnamoyl glucosides and cis-cinnamic acid.

    PubMed

    Hiradate, Syuntaro; Morita, Sayaka; Furubayashi, Akihiro; Fujii, Yoshiharu; Harada, Jiro

    2005-03-01

    Spiraea thunbergii Sieb. contains 1-O-cis-cinnamoyl-beta-D-glucopyranose (CG) and 6-O-(4'-hydroxy-2'-methylene-butyroyl)-1-O-cis-cinnamoyl-beta-D-glucopyranose (BCG) as major plant growth inhibiting constituents. In the present study, we determined the inhibitory activity of CG and BCG on root elongation of germinated seedlings of lettuce (Lactuca sativa), pigweed (Amaranthus retroflexus), red clover (Trifolium pratense), timothy (Phleum pratense), and bok choy (Brassica rapa var chinensis) in comparison with that of two well-known growth inhibitors, 2,4-dichlorophenoxyacetic acid (2,4-D) and (+)-2-cis-4-trans-abscisic acid (cis-ABA), as well as two related chemicals of CG and BCG, cis-cinnamic acid (cis-CA) and trans-cinnamic acid (trans-CA). The EC50 values for CG and BCG on lettuce were roughly one-half to one-quarter of the value for cis-ABA. cis-Cinnamic acid, which is a component of CG and BCG, possessed almost the same inhibitory activity of CG and BCG, suggesting that the essential chemical structure responsible for the inhibitory activity of CG and BCG is cis-CA. The cis-stereochemistry of the methylene moiety is apparently needed for high inhibitory activity, as trans-CA had an EC50 value roughly 100 times that of CG, BCG, and cis-CA. Growth inhibition by CG, BCG, and cis-CA was influenced by the nature of the soil in the growing medium: alluvial soil preserved the bioactivity, whereas volcanic ash and calcareous soils inhibited bioactivity. These findings indicate a potential role of cis-CA and its glucosides as allelochemicals for use as plant growth regulators in agricultural fields.

  7. Substrate influences on CIS device performance

    SciTech Connect

    Dawson-Elli, D.F.; Moore, C.B.; Gay, R.R.; Jensen, C.L.

    1994-12-31

    It has been reported that the substrate plays an active role in copper indium diselenide (CIS) devices. The physical properties of the substrate, i.e., thermal expansion coefficient, chemical composition, strain point, surface quality and cleanliness may all play a role in device efficiency and process reproducibility. For example, sodium is known to influence the conductivity of CIS, and that soda lime glass (SLG) introduces sodium into the CIS. In the experiments reported here, the sodium level in the CIS was varied by (a) changing the substrate composition and (b) the use of SiO{sub x}N{sub y} and SiN{sub x} barrier layers. Cells were fabricated on the candidate substrate and barrier layer combinations. V{sub oc} was observed to drop with the addition of barrier layers to sodium containing glasses. The films were also analyzed for sodium by SIMS. The cell performance and SIMS analysis are presented and their significance is discussed.

  8. University Opinion Poll 8C, Fall 1973. Research Bulletin, University of Minnesota, V14 N8 January 28, 1974.

    ERIC Educational Resources Information Center

    Barnhart, William

    The University Opinion Poll conducted a survey to obtain an estimate of student and staff opinion toward alcohol on campus. Four hundred seventy students and staff, 77% of a random sample of all students and staff at the University of Minnesota, were contacted for their opinions. Most respondents favor having alcoholic beverages on campus and…

  9. Expert opinion vs. empirical evidence

    PubMed Central

    Herman, Rod A; Raybould, Alan

    2014-01-01

    Expert opinion is often sought by government regulatory agencies when there is insufficient empirical evidence to judge the safety implications of a course of action. However, it can be reckless to continue following expert opinion when a preponderance of evidence is amassed that conflicts with this opinion. Factual evidence should always trump opinion in prioritizing the information that is used to guide regulatory policy. Evidence-based medicine has seen a dramatic upturn in recent years spurred by examples where evidence indicated that certain treatments recommended by expert opinions increased death rates. We suggest that scientific evidence should also take priority over expert opinion in the regulation of genetically modified crops (GM). Examples of regulatory data requirements that are not justified based on the mass of evidence are described, and it is suggested that expertise in risk assessment should guide evidence-based regulation of GM crops. PMID:24637724

  10. Communications and Public Opinion: A Public Opinion Quarterly Reader.

    ERIC Educational Resources Information Center

    Carlson, Robert O., Ed.

    The phenomenon of the close relationship between communication and public opinion is shown in this book to have played a major role historically in the measurement of support for political policies, officials, and candidates. The communications media influence public opinion and are subject to it; yet the precise nature and definition of public…

  11. Photochemical trans-/cis-isomerization and quantitation of zearalenone in edible oils.

    PubMed

    Köppen, Robert; Riedel, Juliane; Proske, Matthias; Drzymala, Sarah; Rasenko, Tatjana; Durmaz, Vedat; Weber, Marcus; Koch, Matthias

    2012-11-28

    The emphasis of the present work was to investigate the photochemical conversion of trans- to cis-zearalenone in edible oils under real-life conditions. For quantitation purposes a cis-zearalenone standard was synthesized and characterized for its identity and purity (≥95%) by (1)H NMR, X-ray crystallography, HPLC fluorescence and mass spectrometric detection. In a sample survey of 12 edible oils (9 corn oils, 3 hempseed oils) from local supermarkets all corn oils contained trans-zearalenone (median 194 μg/kg), but no cis-zearalenone was detected. For alteration studies trans-zearalenone contaminated corn oils were exposed to sunlight over 4 and 30 weeks, revealing an obvious shift toward cis-zearalenone up to a cis/trans ratio of 9:1 by storage in colorless glass bottles. Irradiation experiments of trans-zearalenone in different organic solvents confirmed the preferred formation of cis-zearalenone possibly caused by entropic effects rather than by enthalpic entities as investigated by quantum chemical and classical force field simulations.

  12. Coronavirus cis-Acting RNA Elements.

    PubMed

    Madhugiri, R; Fricke, M; Marz, M; Ziebuhr, J

    2016-01-01

    Coronaviruses have exceptionally large RNA genomes of approximately 30 kilobases. Genome replication and transcription is mediated by a multisubunit protein complex comprised of more than a dozen virus-encoded proteins. The protein complex is thought to bind specific cis-acting RNA elements primarily located in the 5'- and 3'-terminal genome regions and upstream of the open reading frames located in the 3'-proximal one-third of the genome. Here, we review our current understanding of coronavirus cis-acting RNA elements, focusing on elements required for genome replication and packaging. Recent bioinformatic, biochemical, and genetic studies suggest a previously unknown level of conservation of cis-acting RNA structures among different coronavirus genera and, in some cases, even beyond genus boundaries. Also, there is increasing evidence to suggest that individual cis-acting elements may be part of higher-order RNA structures involving long-range and dynamic RNA-RNA interactions between RNA structural elements separated by thousands of nucleotides in the viral genome. We discuss the structural and functional features of these cis-acting RNA elements and their specific functions in coronavirus RNA synthesis.

  13. Cis and Trans Isomers of Cycloalkenes

    NASA Astrophysics Data System (ADS)

    Barrows, Susan E.; Eberlein, Thomas H.

    2005-09-01

    As a rule, a trans disubstituted alkene is more stable than the corresponding cis isomer. For cycloalkenes of fewer than eleven members, cis isomers are more stable than their trans counterparts. Although this exception to the normal rule is occasionally noted in beginning organic chemistry textbooks, it is often done without a careful analysis of the reasons behind it. The purpose of this article is to provide that analysis. In order for a cycloalkene to accommodate a trans double bond one or more of the following nonideal geometries must occur: a twisted π bond; pyramidal sp 2 -carbon atoms; nonideal sp 3 bond angles; or longer than normal C C single and double bonds. This article provides a list of experimentally determined relative energies of the cis and trans isomers within the series cycloheptene cycloundecene, along with computationally derived energies at several levels of theory. It also examines the geometric distortions through which cycloalkenes relieve the strain introduced by a trans double bond.

  14. Advances in the CIS research at NREL

    SciTech Connect

    Ramanathan, K.; Bhattacharya, R.N.; Granata, J.; Webb, J.; Niles, D.; Contreras, M.A.; Wiesner, H.; Hasoon, F.S.; Noufi, R.

    1997-12-31

    This paper summarizes the research of the CIS Team at NREL in three major areas: absorber deposition; understanding the role of chemical bath deposited (CBD) CdS in CIS junctions; and in the development of devices without CdS. Low cost, scaleable processes chosen for absorber fabrication include sputtering, electrodeposition (ED), and close spaced sublimation (CSS). The interaction between the CBD and the CIS has been investigated and the results show that Cd might be instrumental in shaping the interface. The authors have also developed a process to fabricate a 13.5% efficiency ZnO/CuInGaSe{sub 2} device without CdS or other buffer layers.

  15. Teachers' Opinions of Student Dropout from Formal Music Education Centres of the Canary Islands

    ERIC Educational Resources Information Center

    Lorenzo Socorro, Sonia; Escandell Bermúdez, María Olga; Castro Sánchez, José Juan

    2016-01-01

    One hundred and eighty-five teachers were surveyed to determine their opinion of student dropout from formal music centres in the Canary Islands. The goal of the study was to investigate the causes of dropout and strategies to prevent it. Teachers' opinions were collected by means of a questionnaire. The influence of the environment on the…

  16. Determining Attitudes and Opinions of Adjunct Instructors Who Teach Online and in Traditional Classroom Classes

    ERIC Educational Resources Information Center

    Vest, Stephen L.

    2009-01-01

    The attitudes and opinions of a selected sample of adjunct instructors toward their academic standings in their profession along with their opinions of the efficacy of online instructional teaching as opposed to the traditional classroom environment were examined in this study. An email survey and recorded interviews were used to collect the data.…

  17. The Vocational Homemaking Teacher Opinion Leader as a Referent in the Communication of Change.

    ERIC Educational Resources Information Center

    Parker, Frances Yoakam

    To investigate the feasibility of using opinion leaders to introduce new ideas in vocational homemaking, 124 vocational homemaking teachers and three regional supervisors of three representative regions in Ohio were surveyed by group-interview technique to determine if vocational homemaking opinion leaders were selected as sources of advice and…

  18. Faculty Opinions on the Use of Master's Degree End of Program Assessments

    ERIC Educational Resources Information Center

    Burke, Susan K.; Snead, John T.

    2014-01-01

    Library and Information Studies (LIS) faculty members responded to a survey of their opinions on the use, advantages, and disadvantages of a variety of end of program assessments (EPAs) in LIS master's programs. Portfolio was the most widely preferred top choice for EPAs, but opinions ranged from preference for no EPA to preference for a…

  19. Examining Student Opinions on Computer Use Based on the Learning Styles in Mathematics Education

    ERIC Educational Resources Information Center

    Ozgen, Kemal; Bindak, Recep

    2012-01-01

    The purpose of this study is to identify the opinions of high school students, who have different learning styles, related to computer use in mathematics education. High school students' opinions on computer use in mathematics education were collected with both qualitative and quantitative approaches in the study conducted with a survey model. For…

  20. Public Opinion in Puerto Rico on Alcohol Control Policies

    ERIC Educational Resources Information Center

    Harwood, Eileen M.; Bernat, Debra H.; Lenk, Kathleen M.; Vazquez, Mary Jo; Wagenaar, Alexander C.

    2004-01-01

    This article discusses the first study to assess public opinion of alcohol policies in Puerto Rico. In 2001, a telephone survey of 514 adults on the island assessed levels of support for 20 alcohol control policies covering five domains: (a) raising alcohol taxes, (b) restricting alcohol consumption in public places, (c) punishing adult providers…

  1. Teachers' Opinions about the Use of Body Language

    ERIC Educational Resources Information Center

    Benzer, Ahmet

    2012-01-01

    Effective communication occurs with non-verbal and verbal tools. In this study the body language as non-verbal communication tool is taken to be examined, and teachers' opinions about the use and importance of body language in education are surveyed. Eight open-ended questions are asked to 100 teachers. As a result, it is shown that teachers…

  2. Pre-Service Teachers' Opinions on Teaching Thinking Skills

    ERIC Educational Resources Information Center

    Akinoglu, Orhan; Karsantik, Yasemin

    2016-01-01

    The purpose of the present study is to determine pre-service teachers' opinions on teaching thinking skills. 134 senior pre-service pre-school, English and mathematics teachers studying at a state university in Istanbul participated in the study which is designed based on survey model. A questionnaire which was developed by the researchers was…

  3. Patients' Opinions about Polish Surgeons and Surgical Treatment.

    PubMed

    Olakowski, Marek; Hładoń, Aleksandra; Seweryn, Mariusz; Ciosek, Jakub; Świątkiewicz, Wojciech

    2016-10-01

    In Polish society Stereotypes about the surgeons are deeply rooted, which could really affect their relationship with the patient and the entire treatment process. The aim of the study was to evaluate the results of an opinion survey on the image of the surgeon and operative treatment.

  4. A Confirmatory Factor Analysis of the Professional Opinion Scale

    ERIC Educational Resources Information Center

    Greeno, Elizabeth J.; Hughes, Anne K.; Hayward, R. Anna; Parker, Karen L.

    2007-01-01

    The Professional Opinion Scale (POS) was developed to measure social work values orientation. Objective: A confirmatory factor analysis was performed on the POS. Method: This cross-sectional study used a mailed survey design with a national random (simple) sample of members of the National Association of Social Workers. Results: The study…

  5. The Misperception of Public Opinion Toward Capital Punishment.

    ERIC Educational Resources Information Center

    McGarrell, Edmund F.; Sandys, Marla

    1996-01-01

    Contends that often lawmakers misread their constituents' opinions on important issues. Presents data from an Indiana survey that suggest support for the death penalty vanishes when citizens are given the option of life in prison without possibility of parole combined with a requirement of work and restitution. (MJP)

  6. Media Coverage and Public Opinion on Scientific Controversies.

    ERIC Educational Resources Information Center

    Mazur, Allan

    1981-01-01

    Examines the relationship of media coverage and public opinion in scientific controversy. A survey of coverage of controversies arising regarding sociobiology, water fluoridation, nuclear power and the Three Mile Island disaster indicates that the media play an active role in shaping and constructing controversy rather than just reporting it. (JMF)

  7. Speech-Language Pathologists' Opinions on Response to Intervention

    ERIC Educational Resources Information Center

    Sanger, Dixie; Mohling, Sara; Stremlau, Aliza

    2012-01-01

    The purpose of this study was to survey the opinions of speech-language pathologists (SLPs) on response to intervention (RTI). Questionnaires were mailed to 2,000 randomly selected elementary and secondary SLPs throughout the United States. Mean results of 583 respondents (29.15%) indicated that SLPs agreed on 37 Likert-type items and responded…

  8. Stereoselective synthesis of cis-p-menth-8-ene-1,7-diol, cis-p-menthane-1,7-diol, and cis-p-menthane-1,7,8-triol.

    PubMed

    Kobler, Christoph; Effenberger, Franz

    2005-04-22

    The natural products cis-p-menthane-1,7-diol (cis-IV), cis-p-menth-8-ene-1,7-diol (cis-I) and cis-p-menthane-1,7,8-triol (cis-II) are obtained starting from the corresponding cis-cyanohydrins, cis-2 and cis-7, respectively, by chemical transformation of the cyano into the hydroxymethyl group. The key step of the synthesis is the very high cis-selectivity (> or = 96 %) of the MeHNL-catalyzed HCN addition to 4-alkylcyclohexanones. From 4-isopropylcyclohexanone (1) the cyanohydrin cis-2 and from 4-(1-methylvinyl)cyclohexanone (6) the cyanohydrin cis-7 result almost quantitatively. Regioselective hydroxylation of cis-I affords the triol cis-II. X-ray crystal structure determinations of the final products confirm their cis-configuration.

  9. Cis-regulatory mutations in human disease

    PubMed Central

    2009-01-01

    Cis-acting regulatory sequences are required for the proper temporal and spatial control of gene expression. Variation in gene expression is highly heritable and a significant determinant of human disease susceptibility. The diversity of human genetic diseases attributed, in whole or in part, to mutations in non-coding regulatory sequences is on the rise. Improvements in genome-wide methods of associating genetic variation with human disease and predicting DNA with cis-regulatory potential are two of the major reasons for these recent advances. This review will highlight select examples from the literature that have successfully integrated genetic and genomic approaches to uncover the molecular basis by which cis-regulatory mutations alter gene expression and contribute to human disease. The fine mapping of disease-causing variants has led to the discovery of novel cis-acting regulatory elements that, in some instances, are located as far away as 1.5 Mb from the target gene. In other cases, the prior knowledge of the regulatory landscape surrounding the gene of interest aided in the selection of enhancers for mutation screening. The success of these studies should provide a framework for following up on the large number of genome-wide association studies that have identified common variants in non-coding regions of the genome that associate with increased risk of human diseases including, diabetes, autism, Crohn's, colorectal cancer, and asthma, to name a few. PMID:19641089

  10. Cis-regulatory mutations in human disease.

    PubMed

    Epstein, Douglas J

    2009-07-01

    Cis-acting regulatory sequences are required for the proper temporal and spatial control of gene expression. Variation in gene expression is highly heritable and a significant determinant of human disease susceptibility. The diversity of human genetic diseases attributed, in whole or in part, to mutations in non-coding regulatory sequences is on the rise. Improvements in genome-wide methods of associating genetic variation with human disease and predicting DNA with cis-regulatory potential are two of the major reasons for these recent advances. This review will highlight select examples from the literature that have successfully integrated genetic and genomic approaches to uncover the molecular basis by which cis-regulatory mutations alter gene expression and contribute to human disease. The fine mapping of disease-causing variants has led to the discovery of novel cis-acting regulatory elements that, in some instances, are located as far away as 1.5 Mb from the target gene. In other cases, the prior knowledge of the regulatory landscape surrounding the gene of interest aided in the selection of enhancers for mutation screening. The success of these studies should provide a framework for following up on the large number of genome-wide association studies that have identified common variants in non-coding regions of the genome that associate with increased risk of human diseases including, diabetes, autism, Crohn's, colorectal cancer, and asthma, to name a few.

  11. Alport syndrome: facts and opinions

    PubMed Central

    Kashtan, Clifford

    2017-01-01

    In this commentary, I review recent advances in Alport syndrome genetics, diagnostics, and therapeutics. I also offer some opinions regarding strategies to optimize the early identification of affected individuals to promote early therapeutic intervention. PMID:28163907

  12. Dynamical model for competing opinions

    NASA Astrophysics Data System (ADS)

    Souza, S. R.; Gonçalves, S.

    2012-05-01

    We propose an opinion model based on agents located at the vertices of a regular lattice. Each agent has an independent opinion (among an arbitrary, but fixed, number of choices) and its own degree of conviction. The latter changes every time two agents which have different opinions interact with each other. The dynamics leads to size distributions of clusters (made up of agents which have the same opinion and are located at contiguous spatial positions) which follow a power law, as long as the range of the interaction between the agents is not too short; i.e., the system self-organizes into a critical state. Short range interactions lead to an exponential cutoff in the size distribution and to spatial correlations which cause agents which have the same opinion to be closely grouped. When the diversity of opinions is restricted to two, a nonconsensus dynamic is observed, with unequal population fractions, whereas consensus is reached if the agents are also allowed to interact with those located far from them. The individual agents' convictions, the preestablished interaction range, and the locality of the interaction between a pair of agents (their neighborhood has no effect on the interaction) are the main characteristics which distinguish our model from previous ones.

  13. AACC CEO Survey: Compensation

    ERIC Educational Resources Information Center

    Phillippe, Kent A.

    2016-01-01

    In 2015, the American Association of Community Colleges (AACC) conducted a survey of community college chief executive officers (CEOs) to collect their opinions on current issues, and gather information on their compensation. This report provides the results from this survey. The AACC CEO Survey was sent to 960 public community college presidents.…

  14. Opinion Dynamics with Confirmation Bias

    PubMed Central

    Allahverdyan, Armen E.; Galstyan, Aram

    2014-01-01

    Background Confirmation bias is the tendency to acquire or evaluate new information in a way that is consistent with one's preexisting beliefs. It is omnipresent in psychology, economics, and even scientific practices. Prior theoretical research of this phenomenon has mainly focused on its economic implications possibly missing its potential connections with broader notions of cognitive science. Methodology/Principal Findings We formulate a (non-Bayesian) model for revising subjective probabilistic opinion of a confirmationally-biased agent in the light of a persuasive opinion. The revision rule ensures that the agent does not react to persuasion that is either far from his current opinion or coincides with it. We demonstrate that the model accounts for the basic phenomenology of the social judgment theory, and allows to study various phenomena such as cognitive dissonance and boomerang effect. The model also displays the order of presentation effect–when consecutively exposed to two opinions, the preference is given to the last opinion (recency) or the first opinion (primacy) –and relates recency to confirmation bias. Finally, we study the model in the case of repeated persuasion and analyze its convergence properties. Conclusions The standard Bayesian approach to probabilistic opinion revision is inadequate for describing the observed phenomenology of persuasion process. The simple non-Bayesian model proposed here does agree with this phenomenology and is capable of reproducing a spectrum of effects observed in psychology: primacy-recency phenomenon, boomerang effect and cognitive dissonance. We point out several limitations of the model that should motivate its future development. PMID:25007078

  15. Physician opinions concerning legal abortion in Bogotá, Colombia.

    PubMed

    Stanhope, Kaitlyn; Rochat, Roger; Fink, Lauren; Richardson, Kalie; Brack, Chelsey; Comeau, Dawn

    2017-01-19

    Since the decriminalisation of abortion in 2006, women in Colombia have continued to seek clandestine abortions, endangering their health and contributing to maternal mortality and morbidity. The goal of this study was to explore physicians' opinions towards and knowledge about legal abortion in Bogotá, Colombia, and key barriers to the legal abortion access. We conducted 13 key informant interviews followed by a survey with a probability sample of 49 doctors working in public hospitals in Bogotá. Interview and survey data showed lack of technical experience in the provision of abortion and nuanced opinions towards its practice. Key informants described ignorance and lack of abortion training in medical schools as key barriers to provision. In the survey, 16/49 respondents had performed an abortion, 24/49 had referred a woman for an abortion and only 33/49 showed correct knowledge of the law.

  16. Status of flexible CIS research at ISET

    NASA Technical Reports Server (NTRS)

    Basol, B. M.; Kapur, V. K.; Minnick, A.; Halani, A.; Leidholm, C. R.

    1994-01-01

    Polycrystalline thin film solar cells fabricated on light-weight, flexible substrates are very attractive for space applications. In this work CulnSe2 (CIS) based thin film devices were processed on metallic foil substrates using the selenization technique. CIS deposition method involved reaction of electron-bean evaporated Cu-In precursor layers with a selenizing atmosphere at around 400 C. Several metallic foils such as Mo, Ti, Al, Ni, and Cu were evaluated as possible substrates for these devices. Solar cells with AM1.5 efficiencies of 9.0-9.34 percent and good mechanical integrity were demonstrated on Mo and Ti foils. Monolithic integration of these devices was also demonstrated up to 4 in x 4 in size.

  17. cis-Regulatory control circuits in development.

    PubMed

    Howard, Meredith L; Davidson, Eric H

    2004-07-01

    During development, an organism undergoes many rounds of pattern formation, generating ever-greater complexity with each ensuing round of cell division and specification. The instructions for executing this process are encoded in the cis-regulatory modules that direct the expression of developmental transcription factors and signaling molecules. Each transcription factor binding site within a cis-regulatory module contributes information about when, where, or how much a gene is turned on, and by dissecting the modules driving a given gene, all the inputs governing expression of the gene can be accurately identified. Furthermore, by mapping the output of each gene to the inputs of other genes, it is possible to reverse engineer developmental circuits and even whole networks. At this higher level of organization, common bilaterian strategies for specifying progenitor fields, locking down regulatory states, and driving development forward emerge.

  18. The Nature of Public Opinion on Education in Norway, Sweden and Finland--Measuring the Degree of Political Polarization at the Mass Level

    ERIC Educational Resources Information Center

    Fladmoe, Audun

    2012-01-01

    The aim of this article is to investigate public opinion on education in Norway, Sweden and Finland. Two questions are investigated: (1) whether there is a "Nordic model" of public opinion, and (2) whether public opinion is characterized by political consensus or conflict. Large-scale surveys from 1981 to 2009 are analyzed. The findings…

  19. PDSS/IMC CIS user's guide

    NASA Technical Reports Server (NTRS)

    1984-01-01

    The Spacelab Payload Development Support System PDSS Image Motion Compensator (IMC) computer interface simulation (CIS) user's manual is given. The software provides a real time interface simulation for the following IMC subsystems: the Dry Rotor Reference Unit, the Advanced Star/Target Reference Optical sensor, the Ultra Violet imaging telescope, the Wisconson Ultraviolet Photopolarimetry Experiment, the Cruciform Power distributor, and the Spacelab Experiment Computer Operating System.

  20. Combinatorial Cis-regulation in Saccharomyces Species.

    PubMed

    Spivak, Aaron T; Stormo, Gary D

    2016-01-15

    Transcriptional control of gene expression requires interactions between the cis-regulatory elements (CREs) controlling gene promoters. We developed a sensitive computational method to identify CRE combinations with conserved spacing that does not require genome alignments. When applied to seven sensu stricto and sensu lato Saccharomyces species, 80% of the predicted interactions displayed some evidence of combinatorial transcriptional behavior in several existing datasets including: (1) chromatin immunoprecipitation data for colocalization of transcription factors, (2) gene expression data for coexpression of predicted regulatory targets, and (3) gene ontology databases for common pathway membership of predicted regulatory targets. We tested several predicted CRE interactions with chromatin immunoprecipitation experiments in a wild-type strain and strains in which a predicted cofactor was deleted. Our experiments confirmed that transcription factor (TF) occupancy at the promoters of the CRE combination target genes depends on the predicted cofactor while occupancy of other promoters is independent of the predicted cofactor. Our method has the additional advantage of identifying regulatory differences between species. By analyzing the S. cerevisiae and S. bayanus genomes, we identified differences in combinatorial cis-regulation between the species and showed that the predicted changes in gene regulation explain several of the species-specific differences seen in gene expression datasets. In some instances, the same CRE combinations appear to regulate genes involved in distinct biological processes in the two different species. The results of this research demonstrate that (1) combinatorial cis-regulation can be inferred by multi-genome analysis and (2) combinatorial cis-regulation can explain differences in gene expression between species.

  1. Combinatorial Cis-regulation in Saccharomyces Species

    PubMed Central

    Spivak, Aaron T.; Stormo, Gary D.

    2016-01-01

    Transcriptional control of gene expression requires interactions between the cis-regulatory elements (CREs) controlling gene promoters. We developed a sensitive computational method to identify CRE combinations with conserved spacing that does not require genome alignments. When applied to seven sensu stricto and sensu lato Saccharomyces species, 80% of the predicted interactions displayed some evidence of combinatorial transcriptional behavior in several existing datasets including: (1) chromatin immunoprecipitation data for colocalization of transcription factors, (2) gene expression data for coexpression of predicted regulatory targets, and (3) gene ontology databases for common pathway membership of predicted regulatory targets. We tested several predicted CRE interactions with chromatin immunoprecipitation experiments in a wild-type strain and strains in which a predicted cofactor was deleted. Our experiments confirmed that transcription factor (TF) occupancy at the promoters of the CRE combination target genes depends on the predicted cofactor while occupancy of other promoters is independent of the predicted cofactor. Our method has the additional advantage of identifying regulatory differences between species. By analyzing the S. cerevisiae and S. bayanus genomes, we identified differences in combinatorial cis-regulation between the species and showed that the predicted changes in gene regulation explain several of the species-specific differences seen in gene expression datasets. In some instances, the same CRE combinations appear to regulate genes involved in distinct biological processes in the two different species. The results of this research demonstrate that (1) combinatorial cis-regulation can be inferred by multi-genome analysis and (2) combinatorial cis-regulation can explain differences in gene expression between species. PMID:26772747

  2. The opinions of Polish nurses and patients on nursing protests.

    PubMed

    Binkowska-Bury, Monika; Marc, Malgorzata; Nagorska, Malgorzata; Januszewicz, Pawel; Ryzko, Jozef

    2013-09-01

    The aim of this study is to explore nurses' and patients' opinions about nurses in Poland going on strike. The study was carried out in Poland between January and June 2009, using 150 nurses and 150 hospitalized patients. The study was conducted using two questionnaire surveys. The main reasons why nursing strikes are organized, in the opinions of nurses, are: higher wages, the improvement of working conditions and the improvement of the image of the nursing profession. The main reasons why nursing strikes are organized, in the opinions of patients, are: higher wages, not abiding standards of employment by government and the improvement of the image of the nursing profession. The main reasons for a lack of active participation in strikes are holidays and occupational and economic matters. Patients and nurses support nursing strikes. Both nurses (53.3%) and patients (42%) said that organizing nursing strikes is right and might improve the occupational situation of nurses.

  3. Does the weather influence public opinion about climate change?

    NASA Astrophysics Data System (ADS)

    Donner, S. D.; McDaniel, J.

    2010-12-01

    Public opinion in North America about the science of anthropogenic climate change and the motivation for policy action has been variable over the past twenty years. The trends in public opinion over time have been attributed the general lack of pressing public concern about climate change to a range of political, economic and psychological factors. One driving force behind the variability in polling data from year to year may be the weather itself. The difference between what we “expect” - the climate - and what we “get” - the weather - can be a major source of confusion and obfuscation in the public discourse about climate change. For example, reaction to moderate global temperatures in 2007 and 2008 may have helped prompt the spread of a “global cooling” meme in the public and the news media. At the same time, a decrease in the belief in the science of climate change and the need for action has been noted in opinion polls. This study analyzes the relationship between public opinion about climate change and the weather in the U.S. since the mid-1980s using historical polling data from several major organizations (e.g. Gallup, Pew, Harris Interactive, ABC News), historical monthly air temperature (NCDC) and a survey of opinion articles from major U.S. newspapers (Washington Post, New York Times, Wall Street Journal, Houston Chronicle, USA Today). Seasonal and annual monthly temperature anomalies for the northeastern U.S and the continental U.S are compared with available national opinion data for three general categories of questions: i) Is the climate warming?, ii) Is the observed warming due to human activity?, and iii) Are you concerned about climate change? The variability in temperature and public opinion over time is also compared with the variability in the fraction of opinion articles in the newspapers (n ~ 7000) which express general agreement or disagreement with IPCC Summary for Policymakers consensus statements on climate change (“most of

  4. Differing professional views or opinions: 1994 Special Review Panel

    SciTech Connect

    1996-09-01

    In July 1994, the Executive Director for Operations of the US Nuclear Regulatory Commission (NRC) appointed a Special Review Panel to assess the Differing Professional View or Opinion (DPV/DPO) process, including its effectiveness, how well it is understood by employees, and the organizational climate for having such views aired and properly decided. An additional area within this review was to address the effectiveness of the DPO procedures as they pertain to public access and confidentiality. Further, the Panel was charged with the review of the submittals completed since the last review to identify employees who made significant contributions to the agency or to the public health and safety but had not been adequately recognized for this contribution. The report presents the Special Review Panel`s evaluation of the NRC`s current process for dealing with Differing Professional Views or Opinions. Provided in this report are the results of an employee opinion survey on the process; highlights and suggestions from interviews with individuals who had submitted a Differing Professional View or Opinion, as well as with agency managers directly involved with the Differing Professional Views or Opinions process; and the Special Review Panel`s recommendations for improving the DPV/DPO process.

  5. How does public opinion become extreme?

    PubMed Central

    Ramos, Marlon; Shao, Jia; Reis, Saulo D. S.; Anteneodo, Celia; Andrade, José S.; Havlin, Shlomo; Makse, Hernán A.

    2015-01-01

    We investigate the emergence of extreme opinion trends in society by employing statistical physics modeling and analysis on polls that inquire about a wide range of issues such as religion, economics, politics, abortion, extramarital sex, books, movies, and electoral vote. The surveys lay out a clear indicator of the rise of extreme views. The precursor is a nonlinear relation between the fraction of individuals holding a certain extreme view and the fraction of individuals that includes also moderates, e.g., in politics, those who are “very conservative” versus “moderate to very conservative” ones. We propose an activation model of opinion dynamics with interaction rules based on the existence of individual “stubbornness” that mimics empirical observations. According to our modeling, the onset of nonlinearity can be associated to an abrupt bootstrap-percolation transition with cascades of extreme views through society. Therefore, it represents an early-warning signal to forecast the transition from moderate to extreme views. Moreover, by means of a phase diagram we can classify societies according to the percolative regime they belong to, in terms of critical fractions of extremists and people’s ties. PMID:25989484

  6. Nuclear power: sex differences in public opinion

    SciTech Connect

    Brody, C.J.

    1981-01-01

    This study attempts to determine the factors that account for the fact that women are both more opposed and uncertain than men concerning the further development of nuclear energy. To that end, data from four national opinion surveys covering the period 1975 to 1979 are employed. Log-linear techniques are used in the analyses. Two plausible explanations for women's greater aversion to nuclear power are presented. The marginality explanation attributes the differential support of men and women for nuclear power to the differential positions which they occupy in the economic, political, and technical spheres within society. Because men hold more central positions in these areas, it is postulated that they will perceive a greater need for additional energy and continued economic growth, believe that the advantages of nuclear power toward these goals are greater, and be more confident in applications of nuclear technology. The fact that men express more favorable attitudes toward nuclear power is thus to be explained by these factors. The safety explanation attributes the sex difference to a greater concern on the part of women about the safety of using nuclear fission to generate electricity. The general thrust of this arguments is that women's greater concern for safety revolves around their reproductive and nurturant roles, and the protection of future generations. Uncertainty is viewed as a special problem. An explanation for women's greater uncertainty, which attributes the difference to a sex-typed expectation concerning the formulation and expression of opinions on complex technical issues, is presented.

  7. How does public opinion become extreme?

    NASA Astrophysics Data System (ADS)

    Ramos, Marlon; Shao, Jia; Reis, Saulo D. S.; Anteneodo, Celia; Andrade, José S.; Havlin, Shlomo; Makse, Hernán A.

    2015-05-01

    We investigate the emergence of extreme opinion trends in society by employing statistical physics modeling and analysis on polls that inquire about a wide range of issues such as religion, economics, politics, abortion, extramarital sex, books, movies, and electoral vote. The surveys lay out a clear indicator of the rise of extreme views. The precursor is a nonlinear relation between the fraction of individuals holding a certain extreme view and the fraction of individuals that includes also moderates, e.g., in politics, those who are “very conservative” versus “moderate to very conservative” ones. We propose an activation model of opinion dynamics with interaction rules based on the existence of individual “stubbornness” that mimics empirical observations. According to our modeling, the onset of nonlinearity can be associated to an abrupt bootstrap-percolation transition with cascades of extreme views through society. Therefore, it represents an early-warning signal to forecast the transition from moderate to extreme views. Moreover, by means of a phase diagram we can classify societies according to the percolative regime they belong to, in terms of critical fractions of extremists and people’s ties.

  8. How does public opinion become extreme?

    PubMed

    Ramos, Marlon; Shao, Jia; Reis, Saulo D S; Anteneodo, Celia; Andrade, José S; Havlin, Shlomo; Makse, Hernán A

    2015-05-19

    We investigate the emergence of extreme opinion trends in society by employing statistical physics modeling and analysis on polls that inquire about a wide range of issues such as religion, economics, politics, abortion, extramarital sex, books, movies, and electoral vote. The surveys lay out a clear indicator of the rise of extreme views. The precursor is a nonlinear relation between the fraction of individuals holding a certain extreme view and the fraction of individuals that includes also moderates, e.g., in politics, those who are "very conservative" versus "moderate to very conservative" ones. We propose an activation model of opinion dynamics with interaction rules based on the existence of individual "stubbornness" that mimics empirical observations. According to our modeling, the onset of nonlinearity can be associated to an abrupt bootstrap-percolation transition with cascades of extreme views through society. Therefore, it represents an early-warning signal to forecast the transition from moderate to extreme views. Moreover, by means of a phase diagram we can classify societies according to the percolative regime they belong to, in terms of critical fractions of extremists and people's ties.

  9. Opinion evolution in open community

    NASA Astrophysics Data System (ADS)

    Pan, Qiuhui; Qin, Yao; Xu, Yiqun; Tong, Mengfei; He, Mingfeng

    We consider a dynamic group composed with a constant number of people and the people will change periodically. Every member in the community owns a value of confidence — a mechanism that measures the agent’s coherence to his or her own attitude. Based on Cellular Automata, the opinions of all agents are synchronously updated. As long as the updating frequency and updating proportion are appropriate, the open system can reach a democracy-like steady state. The majority of agents in the community will hold the same opinion.

  10. Balancer effects in opinion dynamics

    NASA Astrophysics Data System (ADS)

    Cheon, Taksu; Morimoto, Jun

    2016-01-01

    We introduce a novel type of contrarian agent, the balancer, to the Galam model of opinion dynamics, which features group-majority update, in order to account for the existence of social skepticism over one-sidedness. We find that, along with majoritarian floaters and single-sided inflexibles, the inclusion of balancers, who normally act as floaters but oppose inflexibles in their presence, brings about the emergence of a critical point on parametric plane of the dynamical system. Around the critical point, three distinct phases of opinion dynamics separated by discontinuous changes are found.

  11. Community Size, Perceptions of Majority Opinion and Opinion Expression.

    ERIC Educational Resources Information Center

    Salmon, Charles T.; Oshagan, Hayg

    A study examined structural determinants of opinion expression by merging two theoretical perspectives: the "spiral of silence" model advanced by Elisabeth Noelle-Neumann, and the structural approach to communication research offered by Phillip Tichenor, George Donohue, and Clarice Olien. The study also distinguished between different…

  12. Rotational spectroscopy and dipole moment of cis-cis HOONO and DOONO.

    PubMed

    Fry, Juliane L; Drouin, Brian J; Miller, Charles E

    2006-02-28

    The rotational spectrum of cis-cis HOONO has been studied over a broad range of frequencies, 13-840 GHz, using pulsed beam Fourier-transform microwave spectroscopy and room-temperature flow cell submillimeter spectroscopy. The rotational spectrum of the deuterated isotopomer, cis-cis DOONO, has been studied over a subset of this range, 84-640 GHz. Improved spectroscopic constants have been determined for HOONO, and the DOONO spectrum is analyzed for the first time. Weak-field Stark effect measurements in the region of 84-110 GHz have been employed to determine the molecular dipole moments of cis-cis HOONO [mu(a) = 0.542(8) D, mu(b) = 0.918(15) D, mu = 1.07(2) D] and DOONO [mu(a) = 0.517(9) D, mu(b) = 0.930(15) D, mu = 1.06(2) D]. The quadrupole coupling tensor in the principal inertial axis system for the 14N nucleus has been determined to be chi(aa) = 1.4907(25) MHz, chi(bb) = -4.5990(59) MHz, chi(ab) = 3.17(147) MHz, and chi(cc) = 3.1082(59) MHz. Coordinates of the H atom in the center-of-mass frame have been determined with use of the Kraitchman equations, /aH/ = 0.516 A and /bH/ = 1.171 A. The inertial defects of HOONO and DOONO are consistent with a planar equilibrium structure with significant out-of-plane H atom torsional motion. Comparisons of the present results are made to ab initio calculations.

  13. Opinion Summarizationof CustomerComments

    NASA Astrophysics Data System (ADS)

    Fan, Miao; Wu, Guoshi

    Web 2.0 technologies have enabled more and more customers to freely comment on different kinds of entities, such as sellers, products and services. The large scale of information poses the need and challenge of automatic summarization. In many cases, each of the user-generated short comments implies the opinions which rate the target entity. In this paper, we aim to mine and to summarize all the customer comments of a product. The algorithm proposed in this researchis more reliable on opinion identification because it is unsupervised and the accuracy of the result improves as the number of comments increases. Our research is performed in four steps: (1) mining the frequent aspects of a product that have been commented on by customers; (2) mining the infrequent aspects of a product which have been commented by customers (3) identifying opinion words in each comment and deciding whether each opinion word is positive, negative or neutral; (4) summarizing the comments. This paper proposes several novel techniques to perform these tasks. Our experimental results using comments of a number of products sold online demonstrate the effectiveness of the techniques.

  14. Opinion: Writing for the Public

    ERIC Educational Resources Information Center

    Rose, Mike

    2010-01-01

    For the past twenty years or so, the author has been fortunate to write for a fairly broad audience. While he was teaching, or running an educational program, or doing research, he was also composing opinion pieces or commentaries about the work he was doing. This process of writing with part of his attention on the classroom or research site and…

  15. Environmental testing of CIS based modules

    SciTech Connect

    Willett, D.

    1995-11-01

    This report describes environmental testing of Siemen`s CIS modules. Charts and diagrams are presented on data concerning: temporary power loss of laminated mini-modules; the 50 thermal cycle test; the 10 humidity freeze cycle test; results after 1000 hours of exposure to damp heat; and interconnect test structures in damp heat testing. It is concluded that moisture ingress causes permanent increases in the series resistance of modules, and that improved packaging is needed for better high humidity reliability. Also, dry dark heat caused temporary power losses which were recovered in sunlight.

  16. Opinion evolution influenced by informed agents

    NASA Astrophysics Data System (ADS)

    Fan, Kangqi; Pedrycz, Witold

    2016-11-01

    Guiding public opinions toward a pre-set target by informed agents can be a strategy adopted in some practical applications. The informed agents are common agents who are employed or chosen to spread the pre-set opinion. In this work, we propose a social judgment based opinion (SJBO) dynamics model to explore the opinion evolution under the influence of informed agents. The SJBO model distinguishes between inner opinions and observable choices, and incorporates both the compromise between similar opinions and the repulsion between dissimilar opinions. Three choices (support, opposition, and remaining undecided) are considered in the SJBO model. Using the SJBO model, both the inner opinions and the observable choices can be tracked during the opinion evolution process. The simulation results indicate that if the exchanges of inner opinions among agents are not available, the effect of informed agents is mainly dependent on the characteristics of regular agents, including the assimilation threshold, decay threshold, and initial opinions. Increasing the assimilation threshold and decay threshold can improve the guiding effectiveness of informed agents. Moreover, if the initial opinions of regular agents are close to null, the full and unanimous consensus at the pre-set opinion can be realized, indicating that, to maximize the influence of informed agents, the guidance should be started when regular agents have little knowledge about a subject under consideration. If the regular agents have had clear opinions, the full and unanimous consensus at the pre-set opinion cannot be achieved. However, the introduction of informed agents can make the majority of agents choose the pre-set opinion.

  17. Phase transitions in Nowak Sznajd opinion dynamics

    NASA Astrophysics Data System (ADS)

    Wołoszyn, Maciej; Stauffer, Dietrich; Kułakowski, Krzysztof

    2007-05-01

    The Nowak modification of the Sznajd opinion dynamics model on the square lattice assumes that with probability β the opinions flip due to mass-media advertising from down to up, and vice versa. Besides, with probability α the Sznajd rule applies that a neighbour pair agreeing in its two opinions convinces all its six neighbours of that opinion. Our Monte Carlo simulations and mean-field theory find sharp phase transitions in the parameter space.

  18. Opinions and knowledge about climate change science in high school students.

    PubMed

    Harker-Schuch, Inez; Bugge-Henriksen, Christian

    2013-10-01

    This study investigates the influence of knowledge on opinions about climate change in the emerging adults' age group (16-17 years). Furthermore, the effects of a lecture in climate change science on knowledge and opinions were assessed. A survey was conducted in Austria and Denmark on 188 students in national and international schools before and after a lecture in climate change science. The results show that knowledge about climate change science significantly affects opinions about climate change. Students with a higher number of correct answers are more likely to have the opinion that humans are causing climate change and that both individuals and governments are responsible for addressing climate change. The lecture in climate change science significantly improved knowledge development but did not affect opinions. Knowledge was improved by 11 % after the lecture. However, the percentage of correct answers was still below 60 % indicating an urgent need for improving climate change science education.

  19. Opinion Expression as a Rational Behavior.

    ERIC Educational Resources Information Center

    Kim, Sei-Hill

    This study looks at individuals' opinion expressions as a rational behavior based on a conscious calculus of expected benefits and costs (economic analysis). The influences of "issue benefit,""opinion congruence," and "issue knowledge," as sources of benefits and costs on opinion expression were hypothesized and tested. The study also examined the…

  20. Identifying Opinion Leaders to Promote Behavior Change

    ERIC Educational Resources Information Center

    Valente, Thomas W.; Pumpuang, Patchareeya

    2007-01-01

    This article reviews 10 techniques used to identify opinion leaders to promote behavior change. Opinion leaders can act as gatekeepers for interventions, help change social norms, and accelerate behavior change. Few studies document the manner in which opinion leaders are identified, recruited, and trained to promote health. The authors categorize…

  1. Graduate Assessment Survey Report.

    ERIC Educational Resources Information Center

    Santa Fe Community Coll., Gainesville, FL. Office of Institutional Research and Planning.

    Determines the degree to which Santa Fe Community College (Florida) is providing quality educational programs and services to its students. Surveys outgoing students to gather their opinions and perceptions of the educational experiences and services they received while attending the college. The survey instrument is divided into three sections:…

  2. Preparing Our Young People for a Changing World: Policymakers, Business Leaders and the Public Speak out on the Role of Education Technology in America's Classrooms. The Second Annual Milken Exchange on Education Technology Public Opinion Survey.

    ERIC Educational Resources Information Center

    Milken Exchange on Education Technology, Santa Monica, CA.

    This research, based on nationwide telephone surveys of voters, state legislators and legislative staff, and high-level business executives, addressed the priority that respondents place on computers/technology in public education, the perceived benefits--and drawbacks--of computers in public education, and the expectations that respondents have…

  3. A cis-regulatory module activating transcription in the suspensor contains five cis-regulatory elements.

    PubMed

    Henry, Kelli F; Kawashima, Tomokazu; Goldberg, Robert B

    2015-06-01

    Little is known about the molecular mechanisms by which the embryo proper and suspensor of plant embryos activate specific gene sets shortly after fertilization. We analyzed the upstream region of the Scarlet Runner Bean (Phaseolus coccineus) G564 gene in order to understand how genes are activated specifically in the suspensor during early embryo development. Previously, we showed that a 54-bp fragment of the G564 upstream region is sufficient for suspensor transcription and contains at least three required cis-regulatory sequences, including the 10-bp motif (5'-GAAAAGCGAA-3'), the 10 bp-like motif (5'-GAAAAACGAA-3'), and Region 2 motif (partial sequence 5'-TTGGT-3'). Here, we use site-directed mutagenesis experiments in transgenic tobacco globular-stage embryos to identify two additional cis-regulatory elements within the 54-bp cis-regulatory module that are required for G564 suspensor transcription: the Fifth motif (5'-GAGTTA-3') and a third 10-bp-related sequence (5'-GAAAACCACA-3'). Further deletion of the 54-bp fragment revealed that a 47-bp fragment containing the five motifs (the 10-bp, 10-bp-like, 10-bp-related, Region 2 and Fifth motifs) is sufficient for suspensor transcription, and represents a cis-regulatory module. A consensus sequence for each type of motif was determined by comparing motif sequences shown to activate suspensor transcription. Phylogenetic analyses suggest that the regulation of G564 is evolutionarily conserved. A homologous cis-regulatory module was found upstream of the G564 ortholog in the Common Bean (Phaseolus vulgaris), indicating that the regulation of G564 is evolutionarily conserved in closely related bean species.

  4. The Will of the People? The Public's Opinion of the Violent and Repeat Juvenile Offender Act of 1997.

    ERIC Educational Resources Information Center

    Schiraldi, Vincent; Soler, Mark

    The Violent and Repeat Juvenile Offender Act of 1997 (S-10) contains provisions that would affect youths arrested for criminal offenses and status offenses (acts that are not crimes if committed by adults). A telephone survey was conducted by Opinion Research Corporation to determine public opinions about the provisions of S-10. A national…

  5. A Study on Attitude and Opinion towards Using Computer Technology in Teaching among B.Ed. Trainees in Tiruchirappalli District

    ERIC Educational Resources Information Center

    Kumar, C. Ashok

    2015-01-01

    The main aim of the study was to find out whether there was a significant difference in the attitude and opinion towards using Computer Technology in teaching among B.Ed., trainees in terms of select independent variables. Normative survey was the technique employed. Opinion towards Computer Usage and Attitude towards Computer Technology inventory…

  6. The Role of cis Regulatory Evolution in Maize Domestication

    PubMed Central

    Lemmon, Zachary H.; Bukowski, Robert; Sun, Qi; Doebley, John F.

    2014-01-01

    Gene expression differences between divergent lineages caused by modification of cis regulatory elements are thought to be important in evolution. We assayed genome-wide cis and trans regulatory differences between maize and its wild progenitor, teosinte, using deep RNA sequencing in F1 hybrid and parent inbred lines for three tissue types (ear, leaf and stem). Pervasive regulatory variation was observed with approximately 70% of ∼17,000 genes showing evidence of regulatory divergence between maize and teosinte. However, many fewer genes (1,079 genes) show consistent cis differences with all sampled maize and teosinte lines. For ∼70% of these 1,079 genes, the cis differences are specific to a single tissue. The number of genes with cis regulatory differences is greatest for ear tissue, which underwent a drastic transformation in form during domestication. As expected from the domestication bottleneck, maize possesses less cis regulatory variation than teosinte with this deficit greatest for genes showing maize-teosinte cis regulatory divergence, suggesting selection on cis regulatory differences during domestication. Consistent with selection on cis regulatory elements, genes with cis effects correlated strongly with genes under positive selection during maize domestication and improvement, while genes with trans regulatory effects did not. We observed a directional bias such that genes with cis differences showed higher expression of the maize allele more often than the teosinte allele, suggesting domestication favored up-regulation of gene expression. Finally, this work documents the cis and trans regulatory changes between maize and teosinte in over 17,000 genes for three tissues. PMID:25375861

  7. Elementary School Parents' Opinions toward Educational Technology and Its Role in Their Children's Education

    ERIC Educational Resources Information Center

    Biddle, Kevin J.

    2013-01-01

    This study surveyed parents of elementary students in the small Midwestern community of Montpelier, Indiana to elicit their opinions toward the educational technology in their children's school and the role it plays in their education. Montpelier Elementary School (MES) has 223 students from 161 families. A phone survey was done to which about 42%…

  8. Child Assessment at the Preprimary Level: Expert Opinion and State Trends. Occasional Paper.

    ERIC Educational Resources Information Center

    Horton, Carol; Bowman, Barbara T.

    In Spring 2001, Erikson Institute conducted two surveys to provide practical information on the current state of expert opinion and public practice with regard to the assessment of prekindergarten children. The first survey questioned a select group of 25 national leaders in the early childhood field regarding the most important components of a…

  9. Fukushima effects in Germany? Changes in media coverage and public opinion on nuclear power.

    PubMed

    Arlt, Dorothee; Wolling, Jens

    2016-10-01

    Based on a literature review on factors that explain media effects and previous findings on media coverage and public opinion on nuclear power, this article examines the effects of Fukushima on media coverage and public opinion in Germany in two studies. The first study uses content analysis data to analyse changes in media coverage, and the second one is based on panel survey data to examine attitude changes on an individual level. The results of both studies show changes in media coverage and public opinion on nuclear power. Furthermore, the second study reveals that individual attitude changes cannot necessarily be explained by the same factors as the distribution of attitudes.

  10. Your opinion on climate change might not be as common as you think

    NASA Astrophysics Data System (ADS)

    Leviston, Z.; Walker, I.; Morwinski, S.

    2013-04-01

    Political and media debate on the existence and causes of climate change has become increasingly factious in several western countries, often resting on claims and counter-claims about what most citizens really think. There are several well-established phenomena in psychology about how people perceive the prevalence of opinions, including the false consensus effect (a tendency to overestimate how common one's `own' opinion is) and pluralistic ignorance (where most people privately reject an opinion, but assume incorrectly that most others accept it). We investigated these biases in people's opinions about the existence and causes of climate change. In two surveys conducted 12 months apart in Australia (n=5,036 n=5,030), respondents were asked their own opinion about the nature of climate change, and then asked to estimate levels of opinion among the general population. We demonstrate that opinions about climate change are subject to strong false consensus effects, that people grossly overestimate the numbers of people who reject the existence of climate change in the broader community, and that people with high false consensus bias are less likely to change their opinions.

  11. Collective opinion formation on fluctuating networks

    NASA Astrophysics Data System (ADS)

    Ngampruetikorn, Vudtiwat; Stephens, Greg

    Thanks to the advent of online social networks, not only are we more connected than ever but we are also able to design and maintain our own social networks. An insight into this phenomenon will be key to understanding modern societies. To this end, we argue that active network maintenance exposes individuals to selective exposure (preference for agreeing information sources) and we explore how this could affect the structure of social networks and collective opinion formation. More technically, we investigate opinion dynamics on a complex network with fast stochastic rewiring. We show that selective exposure while inducing segregation of agents with different opinions, stabilises consensus state regardless of opinion update rules. We argue further that selective exposure can lead to a shorter time to consensus. The time to consensus has non-trivial dependence on the magnitude of selective exposure. Moreover, we find for some opinion updating rules, selective exposure can increase the lifetime of opinion segregation (polarisation of opinions).

  12. Public opinion and nuclear power decision-making

    SciTech Connect

    Benson, B.

    1991-08-06

    This document discusses public opinion regarding nuclear power which is particularly difficult to tie down because of five important paradoxes that characterize it: it can be based on sound reason, but also on intense emotion; it is both national and local in perspective; at varying times it has seen nuclear power as both clean'' and dirty''; it believes nuclear power is both economic, and uneconomic; and nuclear power is perceived as having a fairly safe record, but being potentially unsafe. Equally as complex as the process by which public opinion is formed is the process by which it is converted into public policy. The American political system has numerous checks and balances designed to moderate the power of public opinion. A complex series of legislative, judicial, and executive branch hurdles must be cleared before any idea, however popular, can become day-to-day operating reality in government. As a result, major changes in policy or programs are difficult, and we may expect that nuclear power will be no different; radical change in one direction or the other is unlikely. Nevertheless, carefully focused programs could achieve modest progress, and carefully designed public opinion surveys could support such programs.

  13. Public opinion and nuclear power decision-making

    SciTech Connect

    Benson, B.

    1991-08-06

    This document discusses public opinion regarding nuclear power which is particularly difficult to tie down because of five important paradoxes that characterize it: it can be based on sound reason, but also on intense emotion; it is both national and local in perspective; at varying times it has seen nuclear power as both ``clean`` and ``dirty``; it believes nuclear power is both economic, and uneconomic; and nuclear power is perceived as having a fairly safe record, but being potentially unsafe. Equally as complex as the process by which public opinion is formed is the process by which it is converted into public policy. The American political system has numerous checks and balances designed to moderate the power of public opinion. A complex series of legislative, judicial, and executive branch hurdles must be cleared before any idea, however popular, can become day-to-day operating reality in government. As a result, major changes in policy or programs are difficult, and we may expect that nuclear power will be no different; radical change in one direction or the other is unlikely. Nevertheless, carefully focused programs could achieve modest progress, and carefully designed public opinion surveys could support such programs.

  14. 2012 Global Management Education Graduate Survey. Survey Report

    ERIC Educational Resources Information Center

    Leach, Laura

    2012-01-01

    Each year for the past 13 years, the Graduate Management Admission Council (GMAC) has conducted a survey of graduate management education students in their final year of business school. The Global Management Education Graduate Survey is distributed to students at participating schools. The survey allows students to express their opinions about…

  15. Polarons and bipolarons in cis-polyacetylene

    NASA Astrophysics Data System (ADS)

    Utz, Wolfram; Förner, Wolfgang

    1998-05-01

    We present a parametrization for the Pariser-Parr-Pople Hamiltonian for the description of cis-polyacetylene (cPA). In contrast to trans-polyacetylene, we have to include symmetry breaking between neighboring sites into the Su-Schrieffer-Heeger-type one-electron part of the Hamiltonian. Our parametrization is based on correlated ab initio calculations on cis-hexatriene and on the results of independent calculations found in the literature. For open-shell systems (singly charged polarons) we use the annihilated unrestricted Hartree-Fock method to avoid the artificial spin contaminations inherent in UHF (unrestricted HF) calculations, which lead to the inclusion of fractions of the correlation energy in UHF total energies which cannot be controlled and are different for different systems and even for different geometries of the same system. Thus UHF is useless for the calculation of potential hypersurfaces and thus in turn for dynamical simulations. We find that in cPA singly-charged polarons are formed, while in doubly-charged chains stable bipolarons are found, although of a quite large width. This is in contrast to recent results reported by Shimoi and Abe [Y. Shimoi and S. Abe, Synth. Met. 69, 687 (1995) and Phys. Rev. B 50, 14 781 (1994)] who found that two singly-charged polarons are more stable for realistic parameter values than a doubly-charged bipolaron. We further find that the charged polarons are mobile in the chain and thus we conclude that polarons and bipolarons can serve as charge carriers (the latter ones spinless) in doped cPA.

  16. Prepare dispersed CIS nano-scale particles and spray coating CIS absorber layers using nano-scale precursors

    NASA Astrophysics Data System (ADS)

    Liou, Jian-Chiun; Diao, Chien-Chen; Lin, Jing-Jenn; Chen, Yen-Lin; Yang, Cheng-Fu

    2014-01-01

    In this study, the Mo-electrode thin films were deposited by a two-stepped process, and the high-purity copper indium selenide-based powder (CuInSe2, CIS) was fabricated by hydrothermal process by Nanowin Technology Co. Ltd. From the X-ray pattern of the CIS precursor, the mainly crystalline phase was CIS, and the almost undetectable CuSe phase was observed. Because the CIS powder was aggregated into micro-scale particles and the average particle sizes were approximately 3 to 8 μm, the CIS power was ground into nano-scale particles, then the 6 wt.% CIS particles were dispersed into isopropyl alcohol to get the solution for spray coating method. Then, 0.1 ml CIS solution was sprayed on the 20 mm × 10 mm Mo/glass substrates, and the heat treatment for the nano-scale CIS solution under various parameters was carried out in a selenization furnace. The annealing temperature was set at 550°C, and the annealing time was changed from 5 to 30 min, without extra Se content was added in the furnace. The influences of annealing time on the densification, crystallization, resistivity ( ρ), hall mobility ( μ), and carrier concentration of the CIS absorber layers were well investigated in this study.

  17. CisMols Analyzer: identification of compositionally similar cis-element clusters in ortholog conserved regions of coordinately expressed genes

    PubMed Central

    Jegga, Anil G.; Gupta, Ashima; Gowrisankar, Sivakumar; Deshmukh, Mrunal A.; Connolly, Steven; Finley, Kevin; Aronow, Bruce J.

    2005-01-01

    Combinatorial interactions of sequence-specific trans-acting factors with localized genomic cis-element clusters are the principal mechanism for regulating tissue-specific and developmental gene expression. With the emergence of expanding numbers of genome-wide expression analyses, the identification of the cis-elements responsible for specific patterns of transcriptional regulation represents a critical area of investigation. Computational methods for the identification of functional cis-regulatory modules are difficult to devise, principally because of the short length and degenerate nature of individual cis-element binding sites and the inherent complexity that is generated by combinatorial interactions within cis-clusters. Filtering candidate cis-element clusters based on phylogenetic conservation is helpful for an individual ortholog gene pair, but combining data from cis-conservation and coordinate expression across multiple genes is a more difficult problem. To approach this, we have extended an ortholog gene-pair database with additional analytical architecture to allow for the analysis and identification of maximal numbers of compositionally similar and phylogenetically conserved cis-regulatory element clusters from a list of user-selected genes. The system has been successfully tested with a series of functionally related and microarray profile-based co-expressed ortholog pairs of promoters and genes using known regulatory regions as training sets and co-expressed genes in the olfactory and immunohematologic systems as test sets. CisMols Analyzer is accessible via a Web interface at . PMID:15980500

  18. U.S./CIS eye joint nuclear rocket venture

    NASA Technical Reports Server (NTRS)

    Clark, John S.; Mcilwain, Melvin C.; Smetanikov, Vladimir; D'Yakov, Evgenij K.; Pavshuk, Vladimir A.

    1993-01-01

    An account is given of the significance for U.S. spacecraft development of a nuclear thermal rocket (NTR) reactor concept that has been developed in the (formerly Soviet) Commonwealth of Independent States (CIS). The CIS NTR reactor employs a hydrogen-cooled zirconium hydride moderator and ternary carbide fuels; the comparatively cool operating temperatures associated with this design promise overall robustness.

  19. Short asymmetric synthesis of (-)- and (+)-cis-lauthisan.

    PubMed

    Carreño, M Carmen; Des Mazery, Renaud; Urbano, Antonio; Colobert, Françoise; Solladié, Guy

    2005-05-12

    The asymmetric synthesis of both enantiomers of cis-lauthisan (3) is achieved in only six steps from diethyl pimelate (4), the key steps being the diastereodivergent reduction of beta-ketosulfoxide 7 and the highly cis-stereoselective Et(3)SiH/TMSOTf-promoted reductive cyclization of enantiopure hydroxy sulfinyl ketones (S)-14 and (R)-14.

  20. Peptidyl-prolyl cis-trans isomerases: structure and functions.

    PubMed

    Pliyev, B K; Gurvits, B Y

    1999-07-01

    Peptidyl-prolyl cis-trans isomerases (PPI) catalyze cis-trans isomerization of imide bonds in peptides and proteins. This review summarizes the literature on the structure and functions of PPIs, their involvement in protein folding, and organization of PPI-containing receptors and membrane channels. A possible role of several PPIs in distant interactions between cells is discussed.

  1. Scholars and Pre-Service Teachers: A Comparison of Opinions of Reading Required for High School Graduation.

    ERIC Educational Resources Information Center

    Leach, Mozelle P.

    A study compared the results of a 1986 survey on the opinions of preservice teachers with those of a survey conducted in 1984 by William Bennett (at that time chairman of the National Endowment for the Humanities). Bennett's survey asked respondents to list 30 works that students should be expected to read before high school graduation.…

  2. Oxylipin Signaling: A Distinct Role for the Jasmonic Acid Precursor cis-(+)-12-Oxo-Phytodienoic Acid (cis-OPDA)

    PubMed Central

    Dave, Anuja; Graham, Ian A.

    2012-01-01

    Oxylipins are lipid-derived compounds, many of which act as signals in the plant response to biotic and abiotic stress. They include the phytohormone jasmonic acid (JA) and related jasmonate metabolites cis-(+)-12-oxo-phytodienoic acid (cis-OPDA), methyl jasmonate, and jasmonoyl-L-isoleucine (JA-Ile). Besides the defense response, jasmonates are involved in plant growth and development and regulate a range of processes including glandular trichome development, reproduction, root growth, and senescence. cis-OPDA is known to possess a signaling role distinct from JA-Ile. The non-enzymatically derived phytoprostanes are structurally similar to cis-OPDA and induce a common set of genes that are not responsive to JA in Arabidopsis thaliana. A novel role for cis-OPDA in seed germination regulation has recently been uncovered based on evidence from double mutants and feeding experiments showing that cis-OPDA interacts with abscisic acid (ABA), inhibits seed germination, and increases ABA INSENSITIVE5 (ABI5) protein abundance. Large amounts of cis-OPDA are esterified to galactolipids in A. thaliana and the resulting compounds, known as Arabidopsides, are thought to act as a rapidly available source of cis-OPDA. PMID:22645585

  3. [Enzymatic formation of a cis,cis-muconic acid derivative using pyrazon-degrading bacteria (author's transl)].

    PubMed

    Blobel, F; Eberspächer, J; Haug, S; Lingens, F

    1976-01-01

    The cis,cis-muconic acid derivative of pyrazon, which was formerly isolated from the medium of pyrazon-degrading bacteria, was formed enzymatically by incubation of the catechol derivative of pyrazon with partially purified ortho pyrocatechase from pyrazon-degrading bacteria.

  4. The dynamics of opinion in hierarchical organizations

    NASA Astrophysics Data System (ADS)

    Laguna, M. F.; Risau Gusman, S.; Abramson, G.; Gonçalves, S.; Iglesias, J. R.

    2005-06-01

    We study the mutual influence of authority and persuasion in the flow of opinions. We describe a simple model with no social mobility, where each agent belongs to a class in the hierarchy and has also a persuasion capability. Agents use the force of its persuasion to propagate their opinions; however a high-rank agent can also use its authority to impose its opinion on other ones. The model is studied analytically within a mean field approximation and by means of numerical simulations. In the case of a three authority level hierarchy the agreement between the two approaches is excellent. We obtain a phase diagram identifying the relative frequency of the prevailing opinions, and find that the stratum where the dominant opinion arises from is strongly dependent on the relative population of each hierarchy level. The time evolution shows that conflicting opinions polarize after a short transient.

  5. Democracy's Denominator: Reassessing Responsiveness with Public Opinion on the National Policy Agenda.

    PubMed

    Barabas, Jason

    2016-01-01

    Democratic responsiveness concerns the degree to which government policies match public preferences. Responsiveness studies typically use national surveys to characterize public opinion, but whether poll questions overlap with the policy agenda is unknown. The first of two empirical analyses presented here, with hundreds of issues on the national agenda in the United States from 1947 to 2000, reveals that public opinion is mostly unrelated to policy outcomes. The picture appears to be even more ominous-that is, opinion and policy are negatively related-on highly salient issues that attract media attention. A second study revisiting published work confirms that responsiveness patterns look different depending upon whether studies of opinion-policy connections (a) begin with survey data and then examine policy developments, or (b) begin with national legislative agenda issues and then examine survey data. Thus, conclusions about democratic responsiveness depend upon the issues that are examined, and often opinion surveys do not include questions about tangible public policy options. In that sense, future changes in democratic responsiveness might go undetected because scholars often lack data on what goes into the denominator of democracy.

  6. EUROPEANS AND RADIOACTIVE WASTE - OPINIONS, BELIEFS AND CONCERNS

    SciTech Connect

    Webster, S.; Taylor, D.M.

    2003-02-27

    In the autumn of 1998, the European Commission conducted a public opinion survey on radioactive waste. Roughly 16,000 people across the European Union (EU) were questioned in face to face interviews. A similar survey was carried out three years later in October and November of 2001, though this time questions of a broader nature concerning nuclear issues in general were also introduced. A comparison of the results of the two surveys shows that in the intervening period there have been very few significant changes in opinion. In particular, the events of 11 September 2001 appear to have had no measurable impact on people's views. The results of the surveys have been analyzed and the key findings extracted and, where possible, interpreted. Though some of these findings might perhaps have been expected, others are somewhat surprising or even worrying, especially for the nuclear sector. However, people still seem prepared to accept that nuclear power should remain an option for electricity production in the EU, but the policy makers and the nuclear industry must demonstrate that the waste issue can be managed both safely and with respect for future generations.

  7. 21 CFR 573.637 - Methyl esters of conjugated linoleic acid (cis-9, trans-11 and trans-10, cis-12-octadecadienoic...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 6 2012-04-01 2012-04-01 false Methyl esters of conjugated linoleic acid (cis-9... § 573.637 Methyl esters of conjugated linoleic acid (cis-9, trans-11 and trans-10, cis-12-octadecadienoic acids). The food additive, methyl esters of conjugated linoleic acid (cis-9, trans-11 and...

  8. Germinating the 2050 Cis-Lunar Econosphere

    NASA Technical Reports Server (NTRS)

    Scott, David W.; Curreri, Peter A.; Ferguson, Cynthia K.; Nall, Mark E.; Tinker, Michael L.; Wright, Gregory M.

    2015-01-01

    In early 2013, Marshall Space Flight Center's upper management chartered a diverse team for a six-week 'sprint' to speculate (in a disciplined manner) and paint (with broad brush strokes) a picture of how earth, space, and public/private entities might be operating and relating to each other... in the year 2100. Two 12-person groups of civil servants, one with members having 15 years or less of NASA experience and the other with more senior members, worked independently and then compared and integrated their conclusions. In 2014, the 'Space 2100' team, with some new team members and different group boundaries, ran a longer sprint to a) develop more detailed estimates of the operations and economics of space activities in the vicinity of the Earth and Moon in the 2050 time frame, b) identify evolutionary paths, barriers, and opportunities, and c) suggest actions and philosophies to enable and invigorate progress towards the vision. This paper explores Space 2100's first two sprints and their projections of NASA's role in what will likely be a highly networked, international space industry and cis-lunar infrastructure.

  9. Germinating the 2050 Cis-Lunar Econosphere

    NASA Technical Reports Server (NTRS)

    Scott, David W.; Tinker, Michael L.; Nall, Mark E.; Wright, Gregory M.

    2015-01-01

    In early 2013, the Marshall Space Flight Center (MSFC) Director and MSFC's Office of Strategic Analysis and Communications (OSAC) chartered a diverse team for a six-week "sprint" to speculate (in a disciplined manner) and paint (with broad brush strokes) a picture of how earth, space, and public/private entities might be operating and relating to each other...in the year 2100. Two 12-person groups of civil servants, one with members having 15 years or less of NASA experience and the other with more senior members, worked independently and then compared and integrated their conclusions. In 2014, the "Space 2100" team, with some new team members and different group boundaries, ran a longer sprint to a) develop more detailed estimates of the operations and economics of space activities in the vicinity of the Earth and Moon in the 2050 time frame, b) identify evolutionary steps and viable paths needed to make that a reality, and c) recommend actions to enable and invigorate those steps. This paper explores Space 2100's first two sprints and their projections of NASA's role in what will likely be a highly networked international space industry and cis-lunar infrastructure.

  10. Prediction of collective opinion in consensus formation

    NASA Astrophysics Data System (ADS)

    Hou, Lei; Liu, Jianguo; Pan, Xue; Song, Wen-Jun; Li, Xu-Dong

    2014-12-01

    In the consensus formation dynamics, the effect of leaders and interventions have been widely studied for it has many applications such as in politics and commerce. However, the problem is how to know if it is necessary for one to make an intervention. In this paper, we theoretically propose a method for predicting the tendency and final state of collective opinion. By giving each agent a conviction ci which measures the ability to insist on his opinion, we present an opinion formation model in which agents with high convictions naturally show up properties of the opinion leaders. Results reveal that, although each agent initially gets an opinion evenly distributed in the range [-1, 1], the collective opinion of the steady-state may deviate to the positive or negative direction because of the initial bias of the leaders' opinions. We further get the correlation coefficient of the linear relationship between the collective opinion and the initial bias according to both the experimental and theoretical analysis. Thus, we could predict the final state at the very beginning of the dynamic only if we get the opinions of a small portion of the population. The prediction would afford us more time and opportunities to make reactions and interventions.

  11. Multi-phase back contacts for CIS solar cells

    DOEpatents

    Rockett, Angus A.; Yang, Li-Chung

    1995-01-01

    Multi-phase, single layer, non-interdiffusing M-Mo back contact metallized films, where M is selected from Cu, Ga, or mixtures thereof, for CIS cells are deposited by a sputtering process on suitable substrates, preferably glass or alumina, to prevent delamination of the CIS from the back contact layer. Typical CIS compositions include CuXSe.sub.2 where X is In or/and Ga. The multi-phase mixture is deposited on the substrate in a manner to provide a columnar microstructure, with micro-vein Cu or/and Ga regions which partially or fully vertically penetrate the entire back contact layer. The CIS semiconductor layer is then deposited by hybrid sputtering and evaporation process. The Cu/Ga-Mo deposition is controlled to produce the single layer two-phase columnar morphology with controllable Cu or Ga vein size less than about 0.01 microns in width. During the subsequent deposition of the CIS layer, the columnar Cu/Ga regions within the molybdenum of the Cu/Ga-Mo back layer tend to partially leach out, and are replaced by columns of CIS. Narrower Cu and/or Ga regions, and those with fewer inner connections between regions, leach out more slowly during the subsequent CIS deposition. This gives a good mechanical and electrical interlock of the CIS layer into the Cu/Ga-Mo back layer. Solar cells employing In-rich CIS semiconductors bonded to the multi-phase columnar microstructure back layer of this invention exhibit vastly improved photo-electrical conversion on the order of 17% greater than Mo alone, improved uniformity of output across the face of the cell, and greater Fill Factor.

  12. Multi-phase back contacts for CIS solar cells

    DOEpatents

    Rockett, A.A.; Yang, L.C.

    1995-12-19

    Multi-phase, single layer, non-interdiffusing M-Mo back contact metallized films, where M is selected from Cu, Ga, or mixtures thereof, for CIS cells are deposited by a sputtering process on suitable substrates, preferably glass or alumina, to prevent delamination of the CIS from the back contact layer. Typical CIS compositions include CuXSe{sub 2} where X is In or/and Ga. The multi-phase mixture is deposited on the substrate in a manner to provide a columnar microstructure, with micro-vein Cu or/and Ga regions which partially or fully vertically penetrate the entire back contact layer. The CIS semiconductor layer is then deposited by hybrid sputtering and evaporation process. The Cu/Ga-Mo deposition is controlled to produce the single layer two-phase columnar morphology with controllable Cu or Ga vein size less than about 0.01 microns in width. During the subsequent deposition of the CIS layer, the columnar Cu/Ga regions within the molybdenum of the Cu/Ga-Mo back layer tend to partially leach out, and are replaced by columns of CIS. Narrower Cu and/or Ga regions, and those with fewer inner connections between regions, leach out more slowly during the subsequent CIS deposition. This gives a good mechanical and electrical interlock of the CIS layer into the Cu/Ga-Mo back layer. Solar cells employing In-rich CIS semiconductors bonded to the multi-phase columnar microstructure back layer of this invention exhibit vastly improved photo-electrical conversion on the order of 17% greater than Mo alone, improved uniformity of output across the face of the cell, and greater Fill Factor. 15 figs.

  13. Public opinions about alcoholism and its treatment.

    PubMed

    Caetano, R

    1987-03-01

    Survey respondents' views about alcoholism as an illness, support for treatment, treatment recommendation and stigma surrounding alcoholics are examined. Subjects (N = 482) comprise a random sample of the population of Contra Costa County, California. About 91% of the respondents agree with the notion that alcoholism is an illness, but 40% also agree that alcoholics drink because they want to. More women than men support the idea that to recover alcoholics will have to quit drinking forever. The contrary is true of the idea of controlled drinking. Education and income are negatively associated with items on loss of control and controlled drinking. Respondents who have had their lives deeply affected by an alcoholic and those who report a drinking problem of their own do not differ in their opinions about alcoholism from those who do not have these characteristics. Alcoholics Anonymous is the most common form of treatment recommended by the respondents. In general, results show considerable support for treatment as well as ambivalence regarding the disease concept.

  14. Geographic variation in opinions on climate change at state and local scales in the USA

    NASA Astrophysics Data System (ADS)

    Howe, Peter D.; Mildenberger, Matto; Marlon, Jennifer R.; Leiserowitz, Anthony

    2015-06-01

    Addressing climate change in the United States requires enactment of national, state and local mitigation and adaptation policies. The success of these initiatives depends on public opinion, policy support and behaviours at appropriate scales. Public opinion, however, is typically measured with national surveys that obscure geographic variability across regions, states and localities. Here we present independently validated high-resolution opinion estimates using a multilevel regression and poststratification model. The model accurately predicts climate change beliefs, risk perceptions and policy preferences at the state, congressional district, metropolitan and county levels, using a concise set of demographic and geographic predictors. The analysis finds substantial variation in public opinion across the nation. Nationally, 63% of Americans believe global warming is happening, but county-level estimates range from 43 to 80%, leading to a diversity of political environments for climate policy. These estimates provide an important new source of information for policymakers, educators and scientists to more effectively address the challenges of climate change.

  15. 24 CFR 1710.17 - Advisory opinion.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Advisory opinion. (a) General. A developer may request an opinion from the Secretary as to whether an... developer should at least cite the applicable statutory or regulatory basis for the exemption or lack of... outside the purview of the Act. (3) An affirmation as shown below: Developer's Affirmation Name...

  16. Internet Censorship in Turkey: University Students' Opinions

    ERIC Educational Resources Information Center

    Ozkan, Hasan; Arikan, Arda

    2009-01-01

    The aim of this paper is to study university students' opinions toward online censorship with references to their socio-political and economic variables. Considering the upwards trend and the increasing number of online restrictions in Turkey, the opinions of university students (n=138) are thought to give significant findings. The questionnaire…

  17. Developing Student Opinions on Agricultural Issues.

    ERIC Educational Resources Information Center

    Walter, Gerry; Reisner, Ann

    1992-01-01

    Presents early evidence from a longitudinal study suggesting that many agricultural college students lack opinions on soil and water conservation issues. Data also suggest encounters with conservation issues in the classroom and elsewhere encourage students, to learn about and form opinions on conservation. (27 references) (Author/MCO)

  18. Public Opinion Poll on Community Priorities: Sacramento

    ERIC Educational Resources Information Center

    Sierra Health Foundation, 2009

    2009-01-01

    The primary goal of this study was to measure public perceptions, opinions and priorities as they pertain to youth issues in Sacramento for the purposes of further developing public and private youth programming and public policy in the Sacramento region. By presenting a "statistically reliable" profile of public opinion on youth issues,…

  19. Opinion formation models on a gradient.

    PubMed

    Gastner, Michael T; Markou, Nikolitsa; Pruessner, Gunnar; Draief, Moez

    2014-01-01

    Statistical physicists have become interested in models of collective social behavior such as opinion formation, where individuals change their inherently preferred opinion if their friends disagree. Real preferences often depend on regional cultural differences, which we model here as a spatial gradient g in the initial opinion. The gradient does not only add reality to the model. It can also reveal that opinion clusters in two dimensions are typically in the standard (i.e., independent) percolation universality class, thus settling a recent controversy about a non-consensus model. However, using analytical and numerical tools, we also present a model where the width of the transition between opinions scales proportional g(-1/4), not proportional g(-4/7) as in independent percolation, and the cluster size distribution is consistent with first-order percolation.

  20. The metabolism of cis- and trans-decalin

    PubMed Central

    Elliott, T. H.; Robertson, J. S.; Williams, R. T.

    1966-01-01

    1. The metabolism of cis- and trans-decalin in the rabbit has been investigated. 2. Both hydrocarbons were oxidized to racemic secondary alcohols and excreted as ether glucuronides in amounts equal to about 60% of the dose administered. The principal glucuronides were isolated as triacetyl methyl esters and as sodium salts. 3. cis-Decalin gave rise mainly to (±)-cis–cis-2-decalol, together with a little cis–trans-2-decalol, and trans-decalin mainly to (±)-trans–cis-2-decalol and a small amount of trans–trans-2-decalol. 4. These results suggest that biological oxidation of the decalins does not occur via a free-radical mechanism. An attempt is made to explain why racemic alcohols are obtained, rather than the more typical optically active products of enzymic reaction, and a mechanism is proposed. It is suggested that enzymes similar to steroid hydroxylases are involved. PMID:5968538

  1. Trans-cis molecular photoswitching in interstellar Space.

    PubMed

    Cuadrado, S; Goicoechea, J R; Roncero, O; Aguado, A; Tercero, B; Cernicharo, J

    2016-12-01

    As many organic molecules, formic acid (HCOOH) has two conformers (trans and cis). The energy barrier to internal conversion from trans to cis is much higher than the thermal energy available in molecular clouds. Thus, only the most stable conformer (trans) is expected to exist in detectable amounts. We report the first interstellar detection of cis-HCOOH. Its presence in ultraviolet (UV) irradiated gas exclusively (the Orion Bar photodissociation region), with a low trans-to-cis abundance ratio of 2.8 ± 1.0, supports a photoswitching mechanism: a given conformer absorbs a stellar photon that radiatively excites the molecule to electronic states above the interconversion barrier. Subsequent fluorescent decay leaves the molecule in a different conformer form. This mechanism, which we specifically study with ab initio quantum calculations, was not considered in Space before but likely induces structural changes of a variety of interstellar molecules submitted to UV radiation.

  2. Trans-cis molecular photoswitching in interstellar Space*

    PubMed Central

    Cuadrado, S.; Goicoechea, J. R.; Roncero, O.; Aguado, A.; Tercero, B.; Cernicharo, J.

    2016-01-01

    As many organic molecules, formic acid (HCOOH) has two conformers (trans and cis). The energy barrier to internal conversion from trans to cis is much higher than the thermal energy available in molecular clouds. Thus, only the most stable conformer (trans) is expected to exist in detectable amounts. We report the first interstellar detection of cis-HCOOH. Its presence in ultraviolet (UV) irradiated gas exclusively (the Orion Bar photodissociation region), with a low trans-to-cis abundance ratio of 2.8 ± 1.0, supports a photoswitching mechanism: a given conformer absorbs a stellar photon that radiatively excites the molecule to electronic states above the interconversion barrier. Subsequent fluorescent decay leaves the molecule in a different conformer form. This mechanism, which we specifically study with ab initio quantum calculations, was not considered in Space before but likely induces structural changes of a variety of interstellar molecules submitted to UV radiation. PMID:28003686

  3. New cis-clerodane diterpenoids from Croton schiedeanus.

    PubMed

    Puebla, Pilar; Correa, Sofía Ximena; Guerrero, Mario; Carron, Rosalía; San Feliciano, Arturo

    2005-03-01

    The acid fraction of extracts from the aerial part of Croton schiedeanus afforded six cis-clerodane type diterpenoids. Two of them (1 and 4) are new natural compounds. Structural elucidation was achieved on the basis of their spectral data.

  4. CisLunar Habitat Internal Architecture Design Criteria

    NASA Technical Reports Server (NTRS)

    Jones, R.; Kennedy, K.; Howard, R.; Whitmore, M.; Martin, C.; Garate, J.

    2017-01-01

    BACKGROUND: In preparation for human exploration to Mars, there is a need to define the development and test program that will validate deep space operations and systems. In that context, a Proving Grounds CisLunar habitat spacecraft is being defined as the next step towards this goal. This spacecraft will operate differently from the ISS or other spacecraft in human history. The performance envelope of this spacecraft (mass, volume, power, specifications, etc.) is being defined by the Future Capabilities Study Team. This team has recognized the need for a human-centered approach for the internal architecture of this spacecraft and has commissioned a CisLunar Phase-1 Habitat Internal Architecture Study Team to develop a NASA reference configuration, providing the Agency with a "smart buyer" approach for future acquisition. THE CISLUNAR HABITAT INTERNAL ARCHITECTURE STUDY: Overall, the CisLunar Habitat Internal Architecture study will address the most significant questions and risks in the current CisLunar architecture, habitation, and operations concept development. This effort is achieved through definition of design criteria, evaluation criteria and process, design of the CisLunar Habitat Phase-1 internal architecture, and the development and fabrication of internal architecture concepts combined with rigorous and methodical Human-in-the-Loop (HITL) evaluations and testing of the conceptual innovations in a controlled test environment. The vision of the CisLunar Habitat Internal Architecture Study is to design, build, and test a CisLunar Phase-1 Habitat Internal Architecture that will be used for habitation (e.g. habitability and human factors) evaluations. The evaluations will mature CisLunar habitat evaluation tools, guidelines, and standards, and will interface with other projects such as the Advanced Exploration Systems (AES) Program integrated Power, Avionics, Software (iPAS), and Logistics for integrated human-in-the-loop testing. The mission of the Cis

  5. Opinions from the Front Lines of Cat Colony Management Conflict

    PubMed Central

    Peterson, M. Nils; Hartis, Brett; Rodriguez, Shari; Green, Matthew; Lepczyk, Christopher A.

    2012-01-01

    Outdoor cats represent a global threat to terrestrial vertebrate conservation, but management has been rife with conflict due to differences in views of the problem and appropriate responses to it. To evaluate these differences we conducted a survey of opinions about outdoor cats and their management with two contrasting stakeholder groups, cat colony caretakers (CCCs) and bird conservation professionals (BCPs) across the United States. Group opinions were polarized, for both normative statements (CCCs supported treating feral cats as protected wildlife and using trap neuter and release [TNR] and BCPs supported treating feral cats as pests and using euthanasia) and empirical statements. Opinions also were related to gender, age, and education, with females and older respondents being less likely than their counterparts to support treating feral cats as pests, and females being less likely than males to support euthanasia. Most CCCs held false beliefs about the impacts of feral cats on wildlife and the impacts of TNR (e.g., 9% believed feral cats harmed bird populations, 70% believed TNR eliminates cat colonies, and 18% disagreed with the statement that feral cats filled the role of native predators). Only 6% of CCCs believed feral cats carried diseases. To the extent the beliefs held by CCCs are rooted in lack of knowledge and mistrust, rather than denial of directly observable phenomenon, the conservation community can manage these conflicts more productively by bringing CCCs into the process of defining data collection methods, defining study/management locations, and identifying common goals related to caring for animals. PMID:22970269

  6. Physicians' opinions following pharmacogenetic testing for psychotropic medication.

    PubMed

    Walden, Lucas M; Brandl, Eva J; Changasi, Amtul; Sturgess, Jessica E; Soibel, Alexander; Notario, Janna Fe D; Cheema, Sheraz; Braganza, Nicole; Marshe, Victoria S; Freeman, Natalie; Tiwari, Arun K; Kennedy, James L; Müller, Daniel J

    2015-10-30

    Pharmacogenetics seeks to improve patient drug response and decrease side effects by personalizing prescriptions using genetic information. Since 2012, by one estimate, the number of patients who have had pharmacogenetic testing has doubled and this number is expected to double again by 2015. Given the increasing evidence for genetic influences on treatment response, we deemed it important to study physicians' opinions of pharmacogenetic testing. Surveys were completed by 168 Canadian physicians who had ordered at least one pharmacogenetic test (in particular for CYP2D6 or CYP2C19) for the prescription of psychiatric medication. Our results indicated that 80% of respondents believe genetic testing would become common standard in psychiatric drug treatment and 76% of respondents reported satisfactory or higher than satisfactory understanding of the pharmacogenetic report provided. Significantly more male physicians believed they had a higher understanding of the pharmacogenetic report compared to female physicians. To our knowledge, this is the only study that has assessed physicians' opinions of pharmacogenetic testing for psychotropic medication after they had received a pharmacogenetic report. Our results demonstrate a positive opinion of physicians on pharmacogenetics and indicate great potential for future clinical application.

  7. Present activies and opinions of scientific and technical information users

    NASA Astrophysics Data System (ADS)

    Fujikura, Ryo; Marumo, Kazuaki

    Present activities and opinions of database users at private enterprises, national institutes or universities are surveyed by a questionnaire and interviews. The investigation includes the following items : 1. Establishment of the inhouse database, 2. Complaints against the existing services of scientific and technical information, 3. Expense for collecting information, 4. Comparison of the database services between public and private, and Japanese and foreign, 5. Requirements to the organization for information service, and government. As the result, they knew that users expect much on the online service and especially wish providers to lower the price and make a single command which enables searchers to make easy access to the various databases.

  8. Workstation Designs for a Cis-Lunar Deep Space Habitat

    NASA Technical Reports Server (NTRS)

    Howe, A. Scott

    2014-01-01

    Using the International Standard Payload Rack (ISPR) system, a suite of workstations required for deep space missions have been proposed to fill out habitation functions in an International Space Station (ISS) derived Cis-lunar Deep Space Habitat. This paper introduces the functional layout of the Cis-lunar habitat design, and describes conceptual designs for modular deployable work surfaces, General Maintenance Workstation (GMWS), In-Space Manufacturing Workstation (ISMW), Intra-Vehicular Activity Telerobotics Work Station (IVA-TRWS), and Galley / Wardroom.

  9. An opinion diffusion model with decision-making groups: The influence of the opinion's acceptability

    NASA Astrophysics Data System (ADS)

    Cheng, Zhichao; Xiong, Yang; Xu, Yiwen

    2016-11-01

    An opinion dynamic model with decision-making groups was proposed to study the process of adopting new opinions or ideas by individuals. The opinion's acceptability is introduced to distinguish the general character of different opinions. The simulation results on a free-scale network demonstrate that when two opinions have similar acceptability, the opinion supported by more decision-making groups in the beginning will eventually win the support of more agents, whereas an opinion supported by fewer decision-making groups in the beginning may be supported by the majority at the end only if it has better acceptability, and if the tolerance threshold of the society is higher than a specific value.

  10. Defining adolescent common mental disorders using electronic primary care data: a comparison with outcomes measured using the CIS-R

    PubMed Central

    Cornish, Rosie P; John, Ann; Boyd, Andy; Tilling, Kate; Macleod, John

    2016-01-01

    Objective To compare the prevalence of common mental disorders (CMDs) derived from data held in primary care records with that measured using the revised Clinical Interview Schedule (CIS-R) in order to assess the potential robustness of findings based only on routinely collected data. Design and setting Comparison study using linkage between the Avon Longitudinal Study of Parents and Children (ALSPAC) and electronic primary care records. Participants We studied 1562 adolescents who had completed the CIS-R in ALSPAC at age 17–18 years and had linkage established to their primary care records. Outcome measures Outcome measures from ALSPAC were whether or not an individual met International Classification of Diseases-10 criteria for a diagnosis of (1) a CMD or, specifically, (2) depression. Lists of Read codes corresponding to diagnoses, symptoms and treatments were used to create 12 definitions of CMD and depression alone using the primary care data. We calculated sensitivities and specificities of these, using CIS-R definitions as the reference standard. Results Sensitivities ranged from 5.2% to 24.3% for depression and from 3.8% to 19.2% for CMD. The specificities of all definitions were above 98% for depression and above 96% for CMD. For both outcomes, the definition that included current diagnosis, treatment or symptoms identified the highest proportion of CIS-R cases. Conclusions Most individuals meeting case definitions for CMD based on primary care data also met CIS-R case definitions. Conversely many individuals identified as cases using the CIS-R had no evidence of CMD in their clinical records. This suggests that clinical databases are likely to yield underestimates of the burden of CMD in the population. However, clinical records appear to yield valid diagnoses which may be useful for studying risk factors and consequences of CMD. The greatest epidemiological value may be obtained when information is available from survey and clinical records. PMID

  11. Measuring and Understanding Public Opinion on Human Evolution

    NASA Astrophysics Data System (ADS)

    Gwon, Misook

    The theory of evolution has long generated controversy in American society, but Americans' attitudes about human evolution are often neglected in studies of "culture wars" and the nature of mass belief systems more generally (Berkman and Plutzer 2010; Freeland and Houston 2009). Gallup and other survey organizations have polled about evolution, but offered limited response categories that mask complexity in public opinion (Bishop 2006; Moore 2008). The main problems concerning the leading survey questions about evolution are: first, questions measure only a single dimension, thus they ignore the potential for multidimensionality in people's attitudes. Second, depending on question wording and response options, the results of public opinion surveys vary by polling groups. This is an example of measurement error which misleads the interpretation and impression of American public opinion on the origin of humankind. A number of studies have analyzed Americans' beliefs about evolution and hypothesized about the influential effects of several factors (Deckman 2002; Mazur 2005; Mooney 2005; Miller et al. 2006; Newport 2006; Forrest 2007;Nisbet and Goidel 2007;Scott 2009). However, there remains a lack of complete understanding of what Americans know and believe about human evolution. Given the salience of this issue and the significant influence of public opinion on policy-making in America (Page and Shapiro 1992; Stimson 2004; Newport 2004), the measurement error and explanation of polling results on controversial issues related to this topic are in need of clarification. In this study, I address these deficiencies with analyses of data from a 2008 national survey by Harris Interactive (n= 4,626) that included numerous measures of factual knowledge and beliefs about evolution. The items offer more nuanced response options than the standard three-category question asked for decades by the Gallup poll. The Harris survey also had multiple measures of religiosity and the

  12. The tomato cis-prenyltransferase gene family.

    PubMed

    Akhtar, Tariq A; Matsuba, Yuki; Schauvinhold, Ines; Yu, Geng; Lees, Hazel A; Klein, Samuel E; Pichersky, Eran

    2013-02-01

    cis-prenyltransferases (CPTs) are predicted to be involved in the synthesis of long-chain polyisoprenoids, all with five or more isoprene (C5) units. Recently, we identified a short-chain CPT, neryl diphosphate synthase (NDPS1), in tomato (Solanum lycopersicum). Here, we searched the tomato genome and identified and characterized its entire CPT gene family, which comprises seven members (SlCPT1-7, with NDPS1 designated as SlCPT1). Six of the SlCPT genes encode proteins with N-terminal targeting sequences, which, when fused to GFP, mediated GFP transport to the plastids of Arabidopsis protoplasts. The SlCPT3-GFP fusion protein was localized to the cytosol. Enzymatic characterization of recombinant SlCPT proteins demonstrated that SlCPT6 produces Z,Z-FPP, and SlCPT2 catalyzes the formation of nerylneryl diphosphate while SlCPT4, SlCPT5 and SlCPT7 synthesize longer-chain products (C25-C55). Although no in vitro activity was demonstrated for SlCPT3, its expression in the Saccharomyces cerevisiae dolichol biosynthesis mutant (rer2) complemented the temperature-sensitive growth defect. Transcripts of SlCPT2, SlCPT4, SlCPT5 and SlCPT7 are present at low levels in multiple tissues, SlCPT6 is exclusively expressed in red fruit and roots, and SlCPT1, SlCPT3 and SlCPT7 are highly expressed in trichomes. RNAi-mediated suppression of NDPS1 led to a large decrease in β-phellandrene (which is produced from neryl diphosphate), with greater reductions achieved with the general 35S promoter compared to the trichome-specific MKS1 promoter. Phylogenetic analysis revealed CPT gene families in both eudicots and monocots, and showed that all the short-chain CPT genes from tomato (SlCPT1, SlCPT2 and SlCPT6) are closely linked to terpene synthase gene clusters.

  13. Community Needs Survey.

    ERIC Educational Resources Information Center

    Arrington, Ronald; And Others

    A telephone survey was conducted by Diablo Valley College (DVC) in 1979 to determine the characteristics of community residents and their opinions concerning DVC's programs and services. In addition to demographic data (i.e., length of residence in Central Contra Costa County, age, size of household, head of household's employment and marital…

  14. Nozomi Cis-Lunar Phase Orbit Determination

    NASA Technical Reports Server (NTRS)

    Ryne, Mark; Criddle, Kevin

    2000-01-01

    Japan's Institute of Space and Astronautical Science (ISAS) launched Nozomi, its first mission to the planet Mars using the newly developed M-V launch vehicle on July 3, 1998. Scientific objectives of the mission are to study the structure and dynamics of the Martian upper atmosphere and its interaction with the solar wind. Nozomi is a cooperative mission between ISAS and the National Aeronautics and Space Administration (NASA). The NASA contribution includes navigation and tracking services provided by the Jet Propulsion Laboratory (JPL). The spacecraft also serves as an engineering demonstration of basic technology for planetary exploration. One of the new technologies was a unique trajectory, developed by ISAS, which used solar gravitational perturbations at the weak stability boundary as an aid to achieve an Earth-Mars transfer orbit. This trajectory saves approximately 120 m/s of Delta V compared to direct hyperbolic insertion and is considered an enabling technology for the mission. Nozomi was the first spacecraft to employ this trajectory and provided on-orbit validation of the technique. The trajectory was achieved by initially placing the spacecraft in a highly elliptical cis-lunar phasing orbit. Six maneuvers were performed during this period to correct injection errors and target an outbound lunar swingby in September 1998. The gravity assist from the lunar swingby raised apogee to the vicinity of the weak stability boundary. After three more targeting maneuvers, Nozomi performed an inbound lunar swingby followed immediately by a powered Earth swingby in late December 1998. A 420 m/s Trans Mars Insertion (TMI) burn at the final Earth periapsis was intended to place the spacecraft on a heliocentric trajectory leading to Mars orbit insertion in October 1999. Orbit determination for Nozomi is performed in parallel by both ISAS and the Multi-Mission Navigation (MMNAV) group at JPL. This was an advantage for the mission because each group would generate

  15. Choice Shift in Opinion Network Dynamics

    NASA Astrophysics Data System (ADS)

    Gabbay, Michael

    Choice shift is a phenomenon associated with small group dynamics whereby group discussion causes group members to shift their opinions in a more extreme direction so that the mean post-discussion opinion exceeds the mean pre-discussion opinion. Also known as group polarization, choice shift is a robust experimental phenomenon and has been well-studied within social psychology. In opinion network models, shifts toward extremism are typically produced by the presence of stubborn agents at the extremes of the opinion axis, whose opinions are much more resistant to change than moderate agents. However, we present a model in which choice shift can arise without the assumption of stubborn agents; the model evolves member opinions and uncertainties using coupled nonlinear differential equations. In addition, we briefly describe the results of a recent experiment conducted involving online group discussion concerning the outcome of National Football League games are described. The model predictions concerning the effects of network structure, disagreement level, and team choice (favorite or underdog) are in accord with the experimental results. This research was funded by the Office of Naval Research and the Defense Threat Reduction Agency.

  16. Californians & Education. PPIC Statewide Survey

    ERIC Educational Resources Information Center

    Baldassare, Mark; Bonner, Dean; Petek, Sonja; Shrestha, Jui

    2014-01-01

    The Public Policy Institute of California (PPIC) Statewide Survey provides policymakers, the media, and the public with objective, advocacy-free information on the perceptions, opinions, and public policy preferences of California residents. This is the 141st PPIC Statewide Survey in a series that was inaugurated in April 1998 and has generated a…

  17. Californians & Education. PPIC Statewide Survey

    ERIC Educational Resources Information Center

    Baldassare, Mark; Bonner, Dean; Petek, Sonja; Shrestha, Jui

    2011-01-01

    The Public Policy Institute of California (PPIC) Statewide Survey series provides policymakers, the media, and the public with objective, advocacy-free information on the perceptions, opinions, and public policy preferences of California residents. Inaugurated in April 1998, this is the 116th PPIC Statewide Survey in a series that has generated a…

  18. Californians & Education. PPIC Statewide Survey

    ERIC Educational Resources Information Center

    Baldassare, Mark; Bonner, Dean; Petek, Sonja; Shrestha, Jui

    2012-01-01

    The Public Policy Institute of California (PPIC) Statewide Survey provides policymakers, the media, and the public with objective, advocacy-free information on the perceptions, opinions, and public policy preferences of California residents. Inaugurated in April 1998, this is the 125th PPIC Statewide Survey in a series that has generated a…

  19. Results of the 2004 U.S. Department of Energy Susrveys Measuring Knowledge of and Opinions on Hydrogen and Fuel Cells

    SciTech Connect

    Truett, Lorena Faith; Cooper, Christy; Schmoyer, Richard L

    2006-01-01

    The U.S. Department of Energy (DOE) Hydrogen Program and Oak Ridge National Laboratory (ORNL) designed and conducted statistical surveys of four distinct populations in the United States during calendar year 2004. The objectives of the surveys were to measure knowledge levels and determine opinions about the use and safety of hydrogen and fuel cells. Results of the surveys establish a baseline for use in developing and guiding an education program. The surveys will be repeated in the future to ascertain any changes in knowledge and opinions over time. The surveys were designed to sample 1,000 individuals in the general public, ages 18 and over; 1,000 students, ages 12-17; 250 state and local government officials; and 100 potential large-scale end users. For every population group, opinions about the safe use of hydrogen as an energy carrier were closely related to technical understanding. Individuals who scored higher on the technical knowledge questions were more likely to have an opinion about hydrogen technology safety and the opinion was more likely to be positive. The methodology was successful in measuring knowledge levels and opinions of the target populations. Because the survey instruments were very similar, comparisons could be made among the target populations. When repeated in the future, the survey results will be able to compare knowledge levels and opinions about hydrogen and fuel cells to the current results. Although knowledge-assessment surveys cannot always pinpoint causality of changes in knowledge and opinions, subsequent surveys identical in methodology to the baseline surveys can measure changes from baseline knowledge levels.

  20. Ten-Year Trends in Public Opinion from the "EDNEXT" Poll

    ERIC Educational Resources Information Center

    Peterson, Paul E.; Henderson, Michael B.; West, Martin R.; Barrows, Samuel

    2017-01-01

    The year 2016 marks the 10th anniversary of the "Education Next" poll on K-12 education policy, offering "Education Next" the opportunity to take a retrospective look at public opinion on this vital topic. In 8 of the past 10 years, "Education Next" has also surveyed teachers on the subject and has seen some…

  1. Characteristics and Opinions of Entering Undergraduate Students at Montana State University.

    ERIC Educational Resources Information Center

    Dulniak, Dennis J.

    Montana State University's (MSU) use of the Student-Outcomes Information Services (SOIS), developed jointly by the National Center for Higher Education Management Systems (NCHEMS) and the College Board for surveying the characteristics and opinions of entering undergraduate students, is examined. The Entering-Student Questionnaire, one of five…

  2. Application of Micro Teaching Skill for Improving the Quality of Teachers: Exploring Opinion of Trainee Teachers

    ERIC Educational Resources Information Center

    Banerjee, Kaustuva; Halder, Santoshi; Guha, Abhijit

    2015-01-01

    The main purpose of this study is to understand the opinion of student trainee teachers towards Microteaching skills. In this study, survey method was adopted. The participants of this study were 130 trainee students from four Teacher Training Colleges of West Bengal, India in 2013-14 sessions. The tools used in the study for data collection was a…

  3. Computer Attitudes and Opinions of Students with and without Learning Disabilities.

    ERIC Educational Resources Information Center

    Brown-Chidsey, Rachel; Boscardin, Mary Lynn; Sireci, Stephen G.

    This study investigated the attitudes and opinions of 970 students with and without learning disabilities regarding the use of computers for school-related work. Using a quasi-experimental design with three non-equivalent groups, within and between subjects effects were studied using a survey instrument. The students in grades 5 through 12 at…

  4. National Public Opinion on School Health Education: Implications for the Health Care Reform Initiatives.

    ERIC Educational Resources Information Center

    Torabi, Mohammad R.; Crowe, James W.

    1995-01-01

    This study investigated national public opinion on school health education and the implications for health-care reform initiatives. Telephone surveys of 1,005 adults nationwide indicated that the public at large believes in the importance of health education to reduce health problems among children, considering it the responsibility of parents and…

  5. Juniors in Germany: Effects and Opinions. An Experimental Evaluation Through Student Polls.

    ERIC Educational Resources Information Center

    Bicknese, Gunther

    This report is based on three separate evaluative surveys. The first compares students' attitudes and opinions before and after the junior year abroad in several areas: (1) attitude toward Germany; (2) integration patterns; (3) religion; (4) politics; (5) the use of tobacco and alcohol, and sexual morality; (6) culture; (7) comparison of…

  6. Evolving Trends in Public Opinion on the Quality of Local Schools

    ERIC Educational Resources Information Center

    Bali, Valentina A.

    2016-01-01

    The ratings given by citizens to local public schools in the United States have been rising in the last decades. Using national public opinion surveys, this study seeks to understand the determinants of public evaluations of local schools across time. Aggregate trend analyses indicate that public evaluations of local schools are influenced not…

  7. Look-Listen Opinion Poll, 1984-1985. Project of the National Telemedia Council, Inc.

    ERIC Educational Resources Information Center

    Giles, Doris, Ed.; And Others

    Designed to indicate the reasons behind viewer program preferences, this 32nd report of an annual opinion poll presents the results of a survey which asked 914 participants to evaluate 3,584 television programs they liked, did not like, and/or to evaluate new programs. Tables summarize the reasons why programs were selected by viewers, their…

  8. Students Opinions and Attitudes towards Physical Education Classes in Kuwait Public Schools

    ERIC Educational Resources Information Center

    Mohammed, Heyam Reda; Mohammad, Mona Ahmad

    2012-01-01

    The aim of study was to investigate student opinion and attitude toward physical education classes. Two thousand seven hundred (2700) students answered the survey: 1239 (45.3%) were male students and 1497 (54.7%) were female from Kuwait six districts: Al_Hawalli, Al_Asimah, Al_Jahra, Al_Mobarak, Al_Farwniah, Al_Ahmadi. Weight Status was determined…

  9. The Attitudes and Opinions of Tutees and Tutors Towards Using Cross-Age Online Tutoring

    ERIC Educational Resources Information Center

    Almassaad, Ahmad; Alotaibi, Khaled

    2012-01-01

    The research aims to identify the attitudes and opinions of tutees and tutors at King Saud University towards using cross-age online tutoring. An electronic survey and interviews were used to collect the data required for this study. A descriptive analysis was used as a research methodology. Thirty participants in this research were asked to…

  10. Plastic Surgeons' Opinions of Facial Surgery for Individuals with Down Syndrome.

    ERIC Educational Resources Information Center

    May, Deborah C.; Turnbull, Nancy

    1992-01-01

    One hundred plastic surgeons responded to a survey on opinions toward facial plastic surgery for individuals with Down's syndrome. Twenty-four of the surgeons had performed the surgery. Surgeons indicated appropriate circumstances for the surgery, consent requirements, degree of understanding expected of the patient, and degree of discomfort…

  11. Public Opinion toward Sexuality Education: Findings among One South Florida County

    ERIC Educational Resources Information Center

    Howard-Barr, Elissa; Moore, Michele Johnson; Weiss, Josie A.; Jobli, Edessa

    2011-01-01

    As part of a community plan to implement abstinence-based sexuality education, this study assessed opinions toward sexuality education among residents. Respondents (N = 1,090) were selected by random digit dialing. The survey, adopted from previous national studies, assessed attitudes towards sexuality education. Chi-square tests of significance…

  12. Designing Graduate-Level Plant Breeding Curriculum: A Delphi Study of Private Sector Stakeholder Opinions

    ERIC Educational Resources Information Center

    Miller, Jane K.; Repinski, Shelby L.; Hayes, Kathryn N.; Bliss, Frederick A.; Trexler, Cary J.

    2011-01-01

    A broad-based survey using the Delphi method was conducted to garner current information from private sector stakeholders and build consensus opinions supporting key ideas for enhancing plant breeder education and training. This study asked respondents to suggest and rate topics and content they deemed most important to plant breeding graduate…

  13. Opinion of AIAW Coaches toward the Use of Selected Ergogenic Aids.

    ERIC Educational Resources Information Center

    Meylink, Willa D.

    The purpose of this survey was to determine the attitude of Association for Intercollegiate Athletics for Women (AIAW) coaches toward the use of selected ergogenic aids by women intercollegiate athletes. Questionnaires were sent to coaches of certain AIAW National and/or Regional Tournament teams. The general opinion items indicated that the…

  14. 78 FR 73238 - Currently Approved Information Collection: Comment Request for Customer Satisfaction and Opinion...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-05

    ... United States Mint Currently Approved Information Collection: Comment Request for Customer Satisfaction... United States Mint customer satisfaction and opinion surveys and focus group interviews. DATES: Written... States Mint products, and to determine the level of satisfaction of United States Mint customers and...

  15. Teachers' Opinions on the Incorporation of Environmental Education in the Nigerian Primary School Curriculum

    ERIC Educational Resources Information Center

    Jekayinfa, Alice Arinlade; Yusuf, Abdul Raheem

    2008-01-01

    This paper presents the report of a research carried out in Kwara Sate of Nigeria to seek the opinions of teachers on the incorporation of Environmental Education (EE) in the Nigerian Primary School Curriculum. The descriptive survey method was employed for the study. 200 teachers were selected through stratified random sampling technique to cater…

  16. Pediatricians' Opinions about Otitis Media and Speech-Language-Hearing Development

    ERIC Educational Resources Information Center

    Sonnenschein, Esther; Cascella, Paul W.

    2004-01-01

    Twenty-five pediatricians responded to a confidential survey about their opinions on the relationship between otitis media and children's speech-language-hearing status. Results found that pediatricians did not necessarily agree that otitis media has an impact on speech-language-hearing development. Pediatricians reported that an early otitis…

  17. The Status of Teachers' Use of Materials According to Teachers' Opinions

    ERIC Educational Resources Information Center

    Sutcu, Selim Soner; Bayir, Safak

    2007-01-01

    The general aim of this research is to determine teachers' use of materials according to teachers' opinions. Research questions were formed within the framework of this aim. This research was carried out within the settings of survey model and questionnaire application. Teachers working in primary schools located in provinces of Ankara constitute…

  18. Opinions of Teachers and Parents Concerning Contemporary Issues Affecting Rural Schools.

    ERIC Educational Resources Information Center

    Peach, Larry E.; Reddick, Thomas L.

    A random selection of 700 parents and teachers representing rural central Tennessee schools was surveyed in order to make their opinions available to policy makers. Usable responses were returned by 196 parents and 224 teachers. Parents opposed increasing public school funds through a lottery; teachers approved. Both groups believed that prayer…

  19. Glucose intolerance following cis-platinum treatment in rats.

    PubMed

    Goldstein, R S; Mayor, G H; Rosenbaum, R W; Hook, J B; Santiago, J V; Bond, J T

    1982-01-01

    cis-Dichlorodiammineplatinum (cis-Pt) is a heavy metal complex used in cancer chemotherapy. Since this drug has been shown to induce hyperglycemia in rats, these studies were initiated to elucidate the effects of cis-Pt on carbohydrate tolerance and insulin and glucagon secretion. Two days following i.v. cis-Pt (2.5 or 7.5 mg/kg, 5 ml/kg) or vehicle administration to male F-344 rats, plasma glucose, immunoreactive insulin (IRI) and glucagon (IRG) concentrations were determined in the basal state and serially following a glucose load (2 g/kg, i.p.). Since cis-Pt induces a dose-related anorexia, a pair-fed control group was also studied. Administration of 7.5 mg/kg cis-Pt was associated with plasma glucose concentrations 2.5-5 times greater than ad-libitum and pair-fed controls at every time point during the 2-h glucose tolerance test. Although basal plasma IRI concentrations of the 7.5-mg/kg group were comparable to ad-libitum fed controls, they were significantly greater than those of pair-fed partners. Furthermore, the appropriate IRI response to a glucose stimulus observed in both controls and the 2.5-mg/kg group was absent in the 7.5-mg/kg group. Basal plasma IRG concentrations of the 7.5-mg/kg group were approximately 3-4 times greater than ad-libitum and pair-fed controls and were not suppressed following a glucose load. These results suggest that cis-Pt induces marked glucose intolerance in association with an impaired IRI response and abnormal glucagon response to a glucose stimulus.

  20. Perceived risk and benefit of nuclear waste repositories: four opinion clusters.

    PubMed

    Seidl, Roman; Moser, Corinne; Stauffacher, Michael; Krütli, Pius

    2013-06-01

    Local public resistance can block the site-selection process, construction, and operation of nuclear waste repositories. Social science has established that the perception of risks and benefits, trust in authorities, and opinion on nuclear energy play important roles in acceptance. In particular, risk and benefit evaluations seem critical for opinion formation. However, risks and benefits have rarely been studied independently and, most often, the focus has been on the two most salient groups of proponents and opponents. The aim of this exploratory study is to examine the often-neglected majority of people holding ambivalent or indifferent opinions. We used cluster analysis to examine the sample (N = 500, mailed survey in German-speaking Switzerland) in terms of patterns of risk and benefit perception. We reveal four significantly different and plausible clusters: one cluster with high-benefit ratings in favor of a repository and one cluster with high-risk ratings opposing it; a third cluster shows ambivalence, with high ratings on both risk and benefit scales and moderate opposition, whereas a fourth cluster seems indifferent, rating risks and benefits only moderately compared to the ambivalent cluster. We conclude that a closer look at the often neglected but considerable number of people with ambivalent or indifferent opinions is necessary. Although the extreme factions of the public will most probably not change their opinion, we do not yet know how the opinion of the ambivalent and indifferent clusters might develop over time.

  1. Evaluating cis-2,6-dimethylpiperidide (cis-DMP) as a base component in lithium-mediated zincation chemistry.

    PubMed

    Armstrong, David R; Garden, Jennifer A; Kennedy, Alan R; Leenhouts, Sarah M; Mulvey, Robert E; O'Keefe, Philip; O'Hara, Charles T; Steven, Alan

    2013-09-27

    Most recent advances in metallation chemistry have centred on the bulky secondary amide 2,2,6,6-tetramethylpiperidide (TMP) within mixed metal, often ate, compositions. However, the precursor amine TMP(H) is rather expensive so a cheaper substitute would be welcome. Thus this study was aimed towards developing cheaper non-TMP based mixed-metal bases and, as cis-2,6-dimethylpiperidide (cis-DMP) was chosen as the alternative amide, developing cis-DMP zincate chemistry which has received meagre attention compared to that of its methyl-rich counterpart TMP. A new lithium diethylzincate, [(TMEDA)LiZn(cis-DMP)Et2] (TMEDA=N,N,N',N'-tetramethylethylenediamine) has been synthesised by co-complexation of Li(cis-DMP), Et2Zn and TMEDA, and characterised by NMR (including DOSY) spectroscopy and X-ray crystallography, which revealed a dinuclear contact ion pair arrangement. By using N,N-diisopropylbenzamide as a test aromatic substrate, the deprotonative reactivity of [(TMEDA)LiZn(cis-DMP)Et2] has been probed and contrasted with that of the known but previously uninvestigated di-tert-butylzincate, [(TMEDA)LiZn(cis-DMP)tBu2]. The former was found to be the superior base (for example, producing the ortho-deuteriated product in respective yields of 78% and 48% following D2O quenching of zincated benzamide intermediates). An 88% yield of 2-iodo-N,N-diisopropylbenzamide was obtained on reaction of two equivalents of the diethylzincate with the benzamide followed by iodination. Comparisons are also drawn using 1,1,1,3,3,3-hexamethyldisilazide (HMDS), diisopropylamide and TMP as the amide component in the lithium amide, Et2Zn and TMEDA system. Under certain conditions, the cis-DMP base system was found to give improved results in comparison to HMDS and diisopropylamide (DA), and comparable results to a TMP system. Two novel complexes isolated from reactions of the di-tert-butylzincate and crystallographically characterised, namely the pre-metallation complex [{(iPr)2N(Ph)C=O}LiZn(cis

  2. Evaluating cis-2,6-Dimethylpiperidide (cis-DMP) as a Base Component in Lithium-Mediated Zincation Chemistry

    PubMed Central

    Armstrong, David R; Garden, Jennifer A; Kennedy, Alan R; Leenhouts, Sarah M; Mulvey, Robert E; O'Keefe, Philip; O'Hara, Charles T; Steven, Alan

    2013-01-01

    Most recent advances in metallation chemistry have centred on the bulky secondary amide 2,2,6,6-tetramethylpiperidide (TMP) within mixed metal, often ate, compositions. However, the precursor amine TMP(H) is rather expensive so a cheaper substitute would be welcome. Thus this study was aimed towards developing cheaper non-TMP based mixed-metal bases and, as cis-2,6-dimethylpiperidide (cis-DMP) was chosen as the alternative amide, developing cis-DMP zincate chemistry which has received meagre attention compared to that of its methyl-rich counterpart TMP. A new lithium diethylzincate, [(TMEDA)LiZn(cis-DMP)Et2] (TMEDA=N,N,N′,N′-tetramethylethylenediamine) has been synthesised by co-complexation of Li(cis-DMP), Et2Zn and TMEDA, and characterised by NMR (including DOSY) spectroscopy and X-ray crystallography, which revealed a dinuclear contact ion pair arrangement. By using N,N-diisopropylbenzamide as a test aromatic substrate, the deprotonative reactivity of [(TMEDA)LiZn(cis-DMP)Et2] has been probed and contrasted with that of the known but previously uninvestigated di-tert-butylzincate, [(TMEDA)LiZn(cis-DMP)tBu2]. The former was found to be the superior base (for example, producing the ortho-deuteriated product in respective yields of 78 % and 48 % following D2O quenching of zincated benzamide intermediates). An 88 % yield of 2-iodo-N,N-diisopropylbenzamide was obtained on reaction of two equivalents of the diethylzincate with the benzamide followed by iodination. Comparisons are also drawn using 1,1,1,3,3,3-hexamethyldisilazide (HMDS), diisopropylamide and TMP as the amide component in the lithium amide, Et2Zn and TMEDA system. Under certain conditions, the cis-DMP base system was found to give improved results in comparison to HMDS and diisopropylamide (DA), and comparable results to a TMP system. Two novel complexes isolated from reactions of the di-tert-butylzincate and crystallographically characterised, namely the pre-metallation complex [{(iPr)2N(Ph)C=O}LiZn(cis

  3. Sexual Opinion Survey: An Exploratory Factor Analysis with Helping Professionals

    ERIC Educational Resources Information Center

    Bloom, Zachary D.; Gutierrez, Daniel; Lambie, Glenn W.

    2015-01-01

    Counselors and marriage and family therapists work with individuals, couples, and families on issues related to sexuality. However, clinicians may be underserving their clients by "not" having adequate training and preparation to work with clients with these presenting issues. One mitigating factor in the treatment of sexual problems is…

  4. [Relevance of nutrition knowledge on clinical practice: medical opinion survey].

    PubMed

    Alvares, Luísa; Moreira, Isabel; Oliveira, António

    2007-01-01

    Although previous studies show that physicians generally agree that nutrition knowledge is important for their daily clinical practice, several other studies report their poor knowledge of the subject. One of the strongest reasons given for this is the non-incorporation of Nutrition as a compulsory subject for the medical sciences degree. Dietary counselling and assessment of the patients' nutritional status don't seem to be systematic. The aim of this study is to asses how relevant physicians consider Nutrition to be in the successful running of a good practice. The study was undertaken at the general hospital of Vila Real/Peso da Régua (CHVR/PR) by distribution of a self- administered questionnaire to 153 of the physicians of the clinical body. Mean values were compared with the Student's t test and proportions with the Chi-square test. Of the 153 physicians, 108 replies were received (70,6%). Of these 108 replies, 53,3% consider nutrition knowledge important although 29,6% state their knowledge is poor. More than half say that Clinical Nutrition should be a compulsory subject of the Medical Sciences syllabus, and 99,1% deem it important to assess the patient's nutritional status. About 95% stated they provided written or verbal nutritional guidance, and most of the physicians had already sought the assistance of a nutritionist. This study shows that the clinical body of the CHVR/PR is aware of the importance nutrition knowledge has in their daily practice. It must be noted, though, that although almost one third of the physicians rate their nutrition knowledge poor, most of them provide nutritional guidance to their patients.

  5. Report on the 1975 Officers’ OER Opinion Survey

    DTIC Science & Technology

    1977-11-01

    reviewer and satisfaction with both OER systems, (d) each have a specific function in the evaluation performance factors, (e) evaluation of potential...different attitudes as a function of certain system were the ones who were most satisfied with demographic and personal variables. A chi-square it. These...satisfaction with the No 2 12 22 22 42 100 INI previous OER system than officers in other raial/ a~arentps re ouned o te naret prcet. thaic grups (Table 11

  6. Social opinion dynamics is not chaotic

    NASA Astrophysics Data System (ADS)

    Lim, Chjan; Zhang, Weituo

    2016-08-01

    Motivated by the research on social opinion dynamics over large and dense networks, a general framework for verifying the monotonicity property of multi-agent dynamics is introduced. This allows a derivation of sociologically meaningful sufficient conditions for monotonicity that are tailor-made for social opinion dynamics, which typically have high nonlinearity. A direct consequence of monotonicity is that social opinion dynamics is nonchaotic. A key part of this framework is the definition of a partial order relation that is suitable for a large class of social opinion dynamics such as the generalized naming games. Comparisons are made to previous techniques to verify monotonicity. Using the results obtained, we extend many of the consequences of monotonicity to this class of social dynamics, including several corollaries on their asymptotic behavior, such as global convergence to consensus and tipping points of a minority fraction of zealots or leaders.

  7. The Bakke Opinions and Equal Protection Doctrine.

    ERIC Educational Resources Information Center

    Karst, Kenneth L.; Horowitz, Harold W.

    1979-01-01

    Constitutional issues addressed in the Supreme Court's decision are reviewed. The opinions rendered by Justice Powell are viewed as reflections of the weakness of recent equal protection theory, and as signs of future doctrine. (GC)

  8. Multiple Functional Variants in cis Modulate PDYN Expression.

    PubMed

    Babbitt, Courtney C; Silverman, Jesse S; Haygood, Ralph; Reininga, Jennifer M; Rockman, Matthew V; Wray, Gregory A

    2010-02-01

    Understanding genetic variation and its functional consequences within cis-regulatory regions remains an important challenge in human genetics and evolution. Here, we present a fine-scale functional analysis of segregating variation within the cis-regulatory region of prodynorphin, a gene that encodes an endogenous opioid precursor with roles in cognition and disease. In order to characterize the functional consequences of segregating variation in cis in a region under balancing selection in different human populations, we examined associations between specific polymorphisms and gene expression in vivo and in vitro. We identified five polymorphisms within the 5' flanking region that affect transcript abundance: a 68-bp repeat recognized in prior studies, as well as two microsatellites and two single nucleotide polymorphisms not previously implicated as functional variants. The impact of these variants on transcription differs by brain region, sex, and cell type, implying interactions between cis genotype and the differentiated state of cells. The effects of individual variants on expression level are not additive in some combinations, implying epistatic interactions between nearby variants. These data reveal an unexpectedly complex relationship between segregating genetic variation and its expression-trait consequences and highlights the importance of close functional scrutiny of natural genetic variation within even relatively well-studied cis-regulatory regions.

  9. DBMS UTILIZATION: A Corporate Information System (CIS) development approach

    NASA Technical Reports Server (NTRS)

    Rozett, P.

    1983-01-01

    The Corporate Information System (CIS), an integrated information system intended to tie the corporation together as a functioning entity, is described. In addition to being a major upgraded automated data processing system, the CIS is a management philosophy which recognizes data as a valuable corporate resource and which distinguishes between data and selected data, or information. It further recognizes that different users need different kinds of information. Plans for CIS development are discussed. It will offer its users not just after-the-fact data, but timely information in a format that is meaningful and useful to the particular user, so that the information can be applied in planning, controlling, and decision making by all levels of management. In effect, CIS will help the corporation itself to function as a total, integrated system by typing together administrative activities through information exchange. The CIS supports the operational, tactical control, and strategic planning functions of the corporation. Operational functions are the day-to-day processing necessary to support the corporation's work, such as purchasing and payroll.

  10. Cis-regulatory mechanisms governing stem and progenitor cell transitions

    PubMed Central

    Johnson, Kirby D.; Kong, Guangyao; Gao, Xin; Chang, Yuan-I; Hewitt, Kyle J.; Sanalkumar, Rajendran; Prathibha, Rajalekshmi; Ranheim, Erik A.; Dewey, Colin N.; Zhang, Jing; Bresnick, Emery H.

    2015-01-01

    Cis-element encyclopedias provide information on phenotypic diversity and disease mechanisms. Although cis-element polymorphisms and mutations are instructive, deciphering function remains challenging. Mutation of an intronic GATA motif (+9.5) in GATA2, encoding a master regulator of hematopoiesis, underlies an immunodeficiency associated with myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). Whereas an inversion relocalizes another GATA2 cis-element (−77) to the proto-oncogene EVI1, inducing EVI1 expression and AML, whether this reflects ectopic or physiological activity is unknown. We describe a mouse strain that decouples −77 function from proto-oncogene deregulation. The −77−/− mice exhibited a novel phenotypic constellation including late embryonic lethality and anemia. The −77 established a vital sector of the myeloid progenitor transcriptome, conferring multipotentiality. Unlike the +9.5−/− embryos, hematopoietic stem cell genesis was unaffected in −77−/− embryos. These results illustrate a paradigm in which cis-elements in a locus differentially control stem and progenitor cell transitions, and therefore the individual cis-element alterations cause unique and overlapping disease phenotypes. PMID:26601269

  11. Précis of implicit nationalism.

    PubMed

    Hassin, Ran R; Ferguson, Melissa J; Kardosh, Rasha; Porter, Shanette C; Carter, Travis J; Dudareva, Veronika

    2009-06-01

    While the study of nationalism has received much attention throughout the social sciences and humanities, the experimental investigation of it lags behind. In this paper we review recent advances in the examination of implicit nationalism. In the first set of experiments we survey, the Palestinian, Israeli, Italian, and Russian flags were primed (or not, in the control conditions) and their effects on political thought and behavior were tested. In the second set the American or the Israeli flag was primed (or not) and prejudice toward African-Americans or Palestinians (respectively) was examined. The results of all experiments suggest that the implicit activation of national cues has far-reaching implications on political thought and behavior as well as on attitudes toward minorities. Under the assumption that the image of national flags is associated in memory with national ideologies, these results suggest that national ideologies can be implicitly pursued in a way that significantly affects our thoughts and behaviors.

  12. cisExpress: motif detection in DNA sequences

    PubMed Central

    Triska, Martin; Grocutt, David; Southern, James; Murphy, Denis J.; Tatarinova, Tatiana

    2013-01-01

    Motivation: One of the major challenges for contemporary bioinformatics is the analysis and accurate annotation of genomic datasets to enable extraction of useful information about the functional role of DNA sequences. This article describes a novel genome-wide statistical approach to the detection of specific DNA sequence motifs based on similarities between the promoters of similarly expressed genes. This new tool, cisExpress, is especially designed for use with large datasets, such as those generated by publicly accessible whole genome and transcriptome projects. cisExpress uses a task farming algorithm to exploit all available computational cores within a shared memory node. We demonstrate the robust nature and validity of the proposed method. It is applicable for use with a wide range of genomic databases for any species of interest. Availability: cisExpress is available at www.cisexpress.org. Contact: tatiana.tatarinova@usc.edu Supplementary information: Supplementary data are available at Bioinformatics online. PMID:23793750

  13. Electric/hybrid vehicle Delphi survey

    SciTech Connect

    Ng, H.K.; Anderson, J.L.; Santini, D.J.

    1995-08-08

    This document presents the methodology and results of the Delphi survey. The viewgraphs depict the surveyed population in detail and the surveyed vehicles attributes such as range, recharging time, velocity, acceleration, etc. These opinions are given for forecast years 2000, 2010, and 2020.

  14. The role of cis-carotenoids in abscisic acid biosynthesis.

    PubMed

    Parry, A D; Babiano, M J; Horgan, R

    1990-08-01

    Evidence has been obtained which is consistent with 9'-cis-neoxanthin being a major precursor of abscisic acid (ABA) in higher plants. A mild, rapid procedure was developed for the extraction and analysis of carotenoids from a range of tissues. Once purified the carotenoids were identified from their light-absorbance properties, reactions with dilute acid, high-performance liquid chromatography Rts, mass spectra and the quasiequilibria resulting from iodine-catalysed or chlorophyllsensitised photoisomerisation. Two possible ABA precursors, 9'-cis-neoxanthin and 9-cis-violaxanthin, were identified in extracts of light-grown and etiolated leaves (of Lycopersicon esculentum, Phaseolus vulgaris, Vicia faba, Pisum sativum, Cicer arietinum, Zea mays, Nicotiana plumbaginifolia, Plantago lanceolata and Digitalis purpurea), and roots of light-grown and etiolated plants (Lycopersicon, Phaseolus and Zea). The 9,9'-di-cisisomer of violaxanthin was synthesised but its presence was not detected in any extracts. Levels of 9'-cis-neoxanthin and all-trans-violaxanthin were between 20- to 100-fold greater than those of ABA in light-grown leaves. The levels of 9-cis-violaxanthin were similar to those of ABA but unaffected by water stress. Etiolated Phaseolus leaves contained reduced amounts of carotenoids (15-20% compared with light-grown leaves) but retained the ability to synthesise large amounts of ABA. The amounts of ABA synthesised, measured as increases in ABA and its metabolites phaseic acid and dihydrophaseic acid, were closely matched by decreases in the levels of 9'-cis-neoxanthin and all-trans-violaxanthin. In etiolated seedlings grown on 50% D2O, deuterium incorporation into ABA was similar to that into the xanthophylls. Relative levels of carotenoids in roots and light-grown and etiolated leaves of the ABA-deficient mutants, notabilis, flacca and sitiens were the same as those found in wild-type tomato tissues.

  15. 28 CFR 80.11 - Effect of FCPA Opinion.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 28 Judicial Administration 2 2013-07-01 2013-07-01 false Effect of FCPA Opinion. 80.11 Section 80.11 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) FOREIGN CORRUPT PRACTICES ACT OPINION PROCEDURE § 80.11 Effect of FCPA Opinion. Except as specified in § 80.10, an FCPA Opinion will not bind...

  16. A Self-Categorization Explanation for Opinion Consensus Perceptions

    ERIC Educational Resources Information Center

    Zhang, Jinguang; Reid, Scott A.

    2013-01-01

    The public expression of opinions (and related communicative activities) hinges upon the perception of opinion consensus. Current explanations for opinion consensus perceptions typically focus on egocentric and other biases, rather than functional cognitions. Using self-categorization theory we showed that opinion consensus perceptions flow from…

  17. Opinion dynamics: Kinetic modelling with mass media, application to the Scottish independence referendum

    NASA Astrophysics Data System (ADS)

    Boudin, Laurent; Salvarani, Francesco

    2016-02-01

    We consider a kinetic model describing some mechanisms of opinion formation in the framework of referendums, where the individuals, who can interact between themselves and modify their opinion by means of spontaneous self-thinking, are moreover under the influence of mass media. We study, at the numerical level, both the transient and the asymptotic regimes. In particular, we point out that a plurality of media, with different orientations, is a key ingredient to allow pluralism and prevent consensus. The forecasts of the model are compared to some surveys related to the Scottish independence referendum of 2014.

  18. 2003 Navy MWR Customer Survey

    DTIC Science & Technology

    2007-06-01

    Thank you VERY much for your opinions! • USE NO. 2 PENCIL ONLY. • Do NOT use ink, ballpoint or felt tip pens . • Erase cleanly and completely any...Sailor’s perspective on specific MWR programs The 2003 survey was designed to maximize comparisons to previous MWR surveys (see Appendix A for actual...The survey asks questions about perceptions of MWR, views of MWR contributions to key military outcomes, and perceptions of specific programs

  19. Opinion formation with time-varying bounded confidence.

    PubMed

    Zhang, YunHong; Liu, QiPeng; Zhang, SiYing

    2017-01-01

    When individuals in social groups communicate with one another and are under the influence of neighbors' opinions, they typically revise their own opinions to adapt to such peer opinions. The individual threshold of bounded confidence will thus be affected by both a change in individual confidence and by neighbor influence. Individuals thus update their own opinions with new bounded confidence, while their updated opinions also influence their neighbors' opinions. Based on this reasoned factual assumption, we propose an opinion dynamics model with time-varying bounded confidence. A directed network is formed by the rule of the individual bounded confidence threshold. The threshold of individual bounded confidence involves both confidence variation and the in/out degree of the individual node. When the confidence variation is greater, an individual's confidence in persisting in his own opinion in interactions is weaker, and the individual is more likely to adopt neighbors' opinions. In networks, the in/out degree is determined by individual neighbors. Our main research involves the process of opinion evolution and the basic laws of opinion cluster formation. Group opinions converge exponentially to consensus with stable neighbors. An individual opinion evolution is determined by the average neighbor opinion effect strength. We also explore the conditions involved in forming a stable neighbor relationship and the influence of the confidence variation in the convergence of the threshold of bounded confidence. The results show that the influence on opinion evolution is greater with increased confidence variation.

  20. Opinion formation with time-varying bounded confidence

    PubMed Central

    Liu, QiPeng; Zhang, SiYing

    2017-01-01

    When individuals in social groups communicate with one another and are under the influence of neighbors’ opinions, they typically revise their own opinions to adapt to such peer opinions. The individual threshold of bounded confidence will thus be affected by both a change in individual confidence and by neighbor influence. Individuals thus update their own opinions with new bounded confidence, while their updated opinions also influence their neighbors’ opinions. Based on this reasoned factual assumption, we propose an opinion dynamics model with time-varying bounded confidence. A directed network is formed by the rule of the individual bounded confidence threshold. The threshold of individual bounded confidence involves both confidence variation and the in/out degree of the individual node. When the confidence variation is greater, an individual’s confidence in persisting in his own opinion in interactions is weaker, and the individual is more likely to adopt neighbors’ opinions. In networks, the in/out degree is determined by individual neighbors. Our main research involves the process of opinion evolution and the basic laws of opinion cluster formation. Group opinions converge exponentially to consensus with stable neighbors. An individual opinion evolution is determined by the average neighbor opinion effect strength. We also explore the conditions involved in forming a stable neighbor relationship and the influence of the confidence variation in the convergence of the threshold of bounded confidence. The results show that the influence on opinion evolution is greater with increased confidence variation. PMID:28264038

  1. Information Filtering Based on Users' Negative Opinions

    NASA Astrophysics Data System (ADS)

    Guo, Qiang; Li, Yang; Liu, Jian-Guo

    2013-05-01

    The process of heat conduction (HC) has recently found application in the information filtering [Zhang et al., Phys. Rev. Lett.99, 154301 (2007)], which is of high diversity but low accuracy. The classical HC model predicts users' potential interested objects based on their interesting objects regardless to the negative opinions. In terms of the users' rating scores, we present an improved user-based HC (UHC) information model by taking into account users' positive and negative opinions. Firstly, the objects rated by users are divided into positive and negative categories, then the predicted interesting and dislike object lists are generated by the UHC model. Finally, the recommendation lists are constructed by filtering out the dislike objects from the interesting lists. By implementing the new model based on nine similarity measures, the experimental results for MovieLens and Netflix datasets show that the new model considering negative opinions could greatly enhance the accuracy, measured by the average ranking score, from 0.049 to 0.036 for Netflix and from 0.1025 to 0.0570 for Movielens dataset, reduced by 26.53% and 44.39%, respectively. Since users prefer to give positive ratings rather than negative ones, the negative opinions contain much more information than the positive ones, the negative opinions, therefore, are very important for understanding users' online collective behaviors and improving the performance of HC model.

  2. Efficient direct ZnO/CIS solar cells

    SciTech Connect

    Olsen, L.C.; William Addis, F.; Lei, W.; Li, J.

    1996-01-01

    This paper describes investigations of CIS solar cells with ZnO window layers deposited by MOCVD. These studies have been conducted with graded absorber CIS substrates obtained from Siemens Solar. Cell fabrication involves surface preparation of the Siemens substrate, growth of 200 to 400 A of undoped ZnO by MOCVD, deposition of a highly conducting ZnO top contact layer and deposition of a Ni/Ag collector grid. MOCVD growth of ZnO is accomplished in a SPIRE 500XT reactor by reacting a zinc adduct and tetrahydrofuran. Processing development has been conducted by forming test cells on ZnO/CIS structures by depositing thin, transparent Al contacts 2.8 mm in diameter on top of the ZnO window layer to serve as contacts. Several cells have been completed with a total area efficiency {ge}11.0{percent}, with the best result being 11.3{percent}. The best active area efficiency is approximately 12{percent}. Other topics discussed include current-voltage characteristics of direct ZnO/CIS cells. {copyright} {ital 1996 American Institute of Physics.}

  3. Trans-cis molecular photoswitching in interstellar space

    NASA Astrophysics Data System (ADS)

    Cuadrado, S.; Goicoechea, J. R.; Roncero, O.; Aguado, A.; Tercero, B.; Cernicharo, J.

    2016-11-01

    As many organic molecules, formic acid (HCOOH) has two conformers (trans and cis). The energy barrier to internal conversion from trans to cis is much higher than the thermal energy available in molecular clouds. Thus, only the most stable conformer (trans) is expected to exist in detectable amounts. We report the first interstellar detection of cis-HCOOH. Its presence in ultraviolet (UV) irradiated gas exclusively (the Orion Bar photodissociation region), with a low trans-to-cis abundance ratio of 2.8 ± 1.0, supports a photoswitching mechanism: a given conformer absorbs a stellar photon that radiatively excites the molecule to electronic states above the interconversion barrier. Subsequent fluorescent decay leaves the molecule in a different conformer form. This mechanism, which we specifically study with ab initio quantum calculations, was not considered in Space before but likely induces structural changes of a variety of interstellar molecules submitted to UV radiation. This paper makes use of observations obtained with the IRAM-30 m telescope. IRAM is supported by INSU/CNRS (France), MPG (Germany), and IGN (Spain).

  4. Creating a Collaborative Learning Community in the CIS Sandbox

    ERIC Educational Resources Information Center

    Frydenberg, Mark

    2013-01-01

    Purpose: The purpose of this paper is to investigate the impact of transforming a traditional university computer lab to create a collaborative learning community known as the CIS Sandbox, by remodeling a physical space and supporting it with a virtual presence through the use of social media tools. The discussion applies Selander's "designs for…

  5. cis- and trans-Stilbenes: Chromatographic Separation and Photochemical Isomerization.

    ERIC Educational Resources Information Center

    Levine, Samuel G.; And Others

    1988-01-01

    Describes an experiment that is to be performed midway in the first semester of an undergraduate organic chemistry laboratory coinciding with the students' introduction to cis-trans isomerism in the study of alkenes. Discusses the apparatus, materials, experimental procedure, historical significance, and results. (CW)

  6. Epistatic Interactions in the Arabinose Cis-Regulatory Element.

    PubMed

    Lagator, Mato; Igler, Claudia; Moreno, Anaísa B; Guet, Călin C; Bollback, Jonathan P

    2016-03-01

    Changes in gene expression are an important mode of evolution; however, the proximate mechanism of these changes is poorly understood. In particular, little is known about the effects of mutations within cis binding sites for transcription factors, or the nature of epistatic interactions between these mutations. Here, we tested the effects of single and double mutants in two cis binding sites involved in the transcriptional regulation of the Escherichia coli araBAD operon, a component of arabinose metabolism, using a synthetic system. This system decouples transcriptional control from any posttranslational effects on fitness, allowing a precise estimate of the effect of single and double mutations, and hence epistasis, on gene expression. We found that epistatic interactions between mutations in the araBAD cis-regulatory element are common, and that the predominant form of epistasis is negative. The magnitude of the interactions depended on whether the mutations are located in the same or in different operator sites. Importantly, these epistatic interactions were dependent on the presence of arabinose, a native inducer of the araBAD operon in vivo, with some interactions changing in sign (e.g., from negative to positive) in its presence. This study thus reveals that mutations in even relatively simple cis-regulatory elements interact in complex ways such that selection on the level of gene expression in one environment might perturb regulation in the other environment in an unpredictable and uncorrelated manner.

  7. 7 CFR 272.10 - ADP/CIS Model Plan.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE FOOD STAMP AND FOOD DISTRIBUTION PROGRAM REQUIREMENTS FOR PARTICIPATING STATE AGENCIES § 272.10 ADP/CIS... automate their food stamp program operations and computerize their systems for obtaining,...

  8. A cis-Regulatory Signature for Chordate Anterior Neuroectodermal Genes

    PubMed Central

    Christiaen, Lionel; Joly, Jean-Stéphane

    2010-01-01

    One of the striking findings of comparative developmental genetics was that expression patterns of core transcription factors are extraordinarily conserved in bilaterians. However, it remains unclear whether cis-regulatory elements of their target genes also exhibit common signatures associated with conserved embryonic fields. To address this question, we focused on genes that are active in the anterior neuroectoderm and non-neural ectoderm of the ascidian Ciona intestinalis. Following the dissection of a prototypic anterior placodal enhancer, we searched all genomic conserved non-coding elements for duplicated motifs around genes showing anterior neuroectodermal expression. Strikingly, we identified an over-represented pentamer motif corresponding to the binding site of the homeodomain protein OTX, which plays a pivotal role in the anterior development of all bilaterian species. Using an in vivo reporter gene assay, we observed that 10 of 23 candidate cis-regulatory elements containing duplicated OTX motifs are active in the anterior neuroectoderm, thus showing that this cis-regulatory signature is predictive of neuroectodermal enhancers. These results show that a common cis-regulatory signature corresponding to K50-Paired homeodomain transcription factors is found in non-coding sequences flanking anterior neuroectodermal genes in chordate embryos. Thus, field-specific selector genes impose architectural constraints in the form of combinations of short tags on their target enhancers. This could account for the strong evolutionary conservation of the regulatory elements controlling field-specific selector genes responsible for body plan formation. PMID:20419150

  9. Structural Brain Network Characteristics Can Differentiate CIS from Early RRMS

    PubMed Central

    Muthuraman, Muthuraman; Fleischer, Vinzenz; Kolber, Pierre; Luessi, Felix; Zipp, Frauke; Groppa, Sergiu

    2016-01-01

    Focal demyelinated lesions, diffuse white matter (WM) damage, and gray matter (GM) atrophy influence directly the disease progression in patients with multiple sclerosis. The aim of this study was to identify specific characteristics of GM and WM structural networks in subjects with clinically isolated syndrome (CIS) in comparison to patients with early relapsing-remitting multiple sclerosis (RRMS). Twenty patients with CIS, 33 with RRMS, and 40 healthy subjects were investigated using 3 T-MRI. Diffusion tensor imaging was applied, together with probabilistic tractography and fractional anisotropy (FA) maps for WM and cortical thickness correlation analysis for GM, to determine the structural connectivity patterns. A network topology analysis with the aid of graph theoretical approaches was used to characterize the network at different community levels (modularity, clustering coefficient, global, and local efficiencies). Finally, we applied support vector machines (SVM) to automatically discriminate the two groups. In comparison to CIS subjects, patients with RRMS were found to have increased modular connectivity and higher local clustering, highlighting increased local processing in both GM and WM. Both groups presented increased modularity and clustering coefficients in comparison to healthy controls. SVM algorithms achieved 97% accuracy using the clustering coefficient as classifier derived from GM and 65% using WM from probabilistic tractography and 67% from modularity of FA maps to differentiate between CIS and RRMS patients. We demonstrate a clear increase of modular and local connectivity in patients with early RRMS in comparison to CIS and healthy subjects. Based only on a single anatomic scan and without a priori information, we developed an automated and investigator-independent paradigm that can accurately discriminate between patients with these clinically similar disease entities, and could thus complement the current dissemination-in-time criteria for

  10. The ethics of gene therapy and abortion: public opinion.

    PubMed

    Evans, M D R; Kelley, Jonathan; Zanjani, Esmail D

    2005-01-01

    On the grounds that the public should be consulted in decisions concerning the legitimate scope of germ-line genetic therapy (GLGT), survey data on the ethics of GLGT were collected from a large (n = 1,403) representative national sample of Australians in 2002. The data show that opinion is quite divided over GLGT in the case of a 'death sentence' genetic defect: 36% would forbid it, 23% have mixed feelings and 41% would allow it. For less serious conditions there is more opposition to GLGT. Thus, 48% would forbid GLGT to remedy a minor physical defect and 52% would oppose GLGT to counteract a propensity to violence, but fully 73% would disallow GLGT for cosmetic reasons. The data also show that opposition to abortion is lower than opposition to GLGT in the case of a 'death sentence' genetic defect, but at about the same level as, or greater than, opposition to GLGT for less serious issues. The questions show good measurement properties, including low missing data rates, so they are likely to provide an accurate picture of the public's views on the ethics of GLGT. It is suggested that a system for monitoring public opinion on these issues be developed.

  11. Attitudes and opinions on corporal punishment among urban Israeli Jews.

    PubMed

    Gofin, Rosa; Levav, Itzhak; Kohn, Robert

    2004-01-01

    Corporal punishment of children constitutes a human rights violation and has mental health consequences, yet it is frequently practiced in many countries. The objectives of this study were to identify attitudes and opinions with regard to corporal punishment among urban Jewish Israelis. Corporal punishment was defined as the means to discipline children by the use of physical force. A short battery of questions exploring attitudes and opinions on the use of corporal punishment of children was added to a periodic survey conducted by a private polling organization. The sample included 1,000 urban Jewish Israeli community residents. Most respondents did not endorse corporal punishment. However, when confronted with a question tapping the readiness of adults to comply with a ruling by the Supreme Court that prohibits the use of corporal punishment at home, most respondents expressed skepticism that the public will comply. Forty percent thought that most parents would agree to undergo training in the use of alternative means of discipline. Fifty-seven percent experienced physical punishment when growing up, a variable which was associated with all responses favoring its use as a means of discipline. The results of the study provide the bases for public health action, including training programs on alternative methods of discipline. Further research targeting other population groups not yet explored is needed.

  12. Analysing Customer Opinions with Text Mining Algorithms

    NASA Astrophysics Data System (ADS)

    Consoli, Domenico

    2009-08-01

    Knowing what the customer thinks of a particular product/service helps top management to introduce improvements in processes and products, thus differentiating the company from their competitors and gain competitive advantages. The customers, with their preferences, determine the success or failure of a company. In order to know opinions of the customers we can use technologies available from the web 2.0 (blog, wiki, forums, chat, social networking, social commerce). From these web sites, useful information must be extracted, for strategic purposes, using techniques of sentiment analysis or opinion mining.

  13. Cis-trans isomerization in the S1 state of acetylene: identification of cis-well vibrational levels.

    PubMed

    Merer, Anthony J; Steeves, Adam H; Baraban, Joshua H; Bechtel, Hans A; Field, Robert W

    2011-06-28

    A systematic analysis of the S(1)-trans (Ã(1)A(u)) state of acetylene, using IR-UV double resonance along with one-photon fluorescence excitation spectra, has allowed assignment of at least part of every single vibrational state or polyad up to a vibrational energy of 4200 cm(-1). Four observed vibrational levels remain unassigned, for which no place can be found in the level structure of the trans-well. The most prominent of these lies at 46 175 cm(-1). Its (13)C isotope shift, exceptionally long radiative lifetime, unexpected rotational selection rules, and lack of significant Zeeman effect, combined with the fact that no other singlet electronic states are expected at this energy, indicate that it is a vibrational level of the S(1)-cis isomer (Ã(1)A(2)). Guided by ab initio calculations [J. H. Baraban, A. R. Beck, A. H. Steeves, J. F. Stanton, and R. W. Field, J. Chem. Phys. 134, 244311 (2011)] of the cis-well vibrational frequencies, the vibrational assignments of these four levels can be established from their vibrational symmetries together with the (13)C isotope shift of the 46 175 cm(-1) level (assigned here as cis-3(1)6(1)). The S(1)-cis zero-point level is deduced to lie near 44 900 cm(-1), and the ν(6) vibrational frequency of the S(1)-cis well is found to be roughly 565 cm(-1); these values are in remarkably good agreement with the results of recent ab initio calculations. The 46 175 cm(-1) vibrational level is found to have a 3.9 cm(-1) staggering of its K-rotational structure as a result of quantum mechanical tunneling through the isomerization barrier. Such tunneling does not give rise to ammonia-type inversion doubling, because the cis and trans isomers are not equivalent; instead the odd-K rotational levels of a given vibrational level are systematically shifted relative to the even-K rotational levels, leading to a staggering of the K-structure. These various observations represent the first definite assignment of an isomer of

  14. Political opinion formation: Initial opinion distribution and individual heterogeneity of tolerance

    NASA Astrophysics Data System (ADS)

    Jin, Cheng; Li, Yifu; Jin, Xiaogang

    2017-02-01

    Opinion dynamics on networks have received serious attention for its profound prospects in social behaviours and self-organized systems. However, political opinion formation, as one typical and significant case, remains lacking in discussion. Previous agent-based simulations propose various models that are based on different mechanisms like the coevolution between network topology and status transition. Nonetheless, even under the same network topology and with the same simple mechanism, forming opinions can still be uncertain. In this work, we propose two features, the initial distribution of opinions and the individual heterogeneity of tolerances on opinion changing, in political opinion formation. These two features are imbedded in the network construction phase of a classical model. By comparing multi simple-party systems, along with a detailed analysis on the two-party system, we capture the critical phenomenon of fragmentation, polarization and consensus both in the persistent stable stage and in-process. We further introduce the average ratio of nearest neighbours to characterize the stage of opinion formation. The results show that the initial distribution of opinions leads to different evolution results on similar random networks. In addition, the existence of stubborn nodes plays a special role: only nodes that are extremely stubborn can cause the change of final opinion distribution while in other cases they only delay the time to reach stability. If stubborn nodes are small in number, their effects are confined within a small range. This theoretical work goes deeper on an existing model, it is an early exploration on qualitative and quantitative simulation of party competition.

  15. Using Online Surveys to Engage a School Community

    ERIC Educational Resources Information Center

    Ayers, Steven

    2012-01-01

    In the not-too-distant past, using surveys to gauge public opinion was a costly and time-consuming activity that districts generally had to outsource. Today, with the advent of online survey tools such as Survey Monkey and Zoomerang and an increasingly Internet-connected society, surveys have become a useful and accessible tool for school…

  16. Factors affecting the opinions of family physicians regarding generic drugs – a questionnaire based study

    PubMed Central

    Lewek, Pawel; Smigielski, Janusz; Kardas, Przemyslaw

    2015-01-01

    A range of factors are believed to exert a negative influence on opinions of physicians about generic drugs. The aim of this study was to survey the opinions of primary care doctors on generics, and determine the factors which may affect them. A questionnaire comprising thirty eight questions was distributed among primary care doctors working in seventy out-patient clinics of the Lodzkie province, Poland, during the period of January 1, 2010 – December 31, 2010. A total of 170 of 183 participants completed the survey (average age 48.5; 70.0% women): a 92.9% response rate. While 38.8% of physicians claimed that generics were worse than brand name drugs, 54.1% considered them to be better. However, 36.5% of the doctors did not choose generics for their own use. Two key opinions were identified among the responses concerning the effectiveness of generic drugs: use of generic drugs by the physician (p<0.001), and their opinion that pharmacists do inform patients about generic drugs (p<0.05). Although existing evidence confirms that generic and brand name drugs are equally effective, many physicians doubt this, which prevents them from being used as cost effective drug therapy. In order to increase healthcare savings through the use of generics, these factors should be addressed: for example, convincing a physician to adopt generics for personal use may be an efficient way to support more cost effective treatment of his patients. PMID:25725136

  17. 24 CFR 1710.17 - Advisory opinion.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 5 2014-04-01 2014-04-01 false Advisory opinion. 1710.17 Section 1710.17 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued... the Housing and Urban Development Act of 1968 (83 Stat. 598, 15 U.S.C. 1717 as amended) provides:...

  18. Farmers' Opinions about Third-Wave Technologies.

    ERIC Educational Resources Information Center

    Lasley, Paul; Bultena, Gordon

    The opinions of 1,585 Iowa farmers about 8 emergent agricultural technologies (energy production from feed grains and oils; energy production from livestock waste; genetic engineering research on plants, livestock, and humans; robotics for on-farm use; confinement livestock facilities; and personal computers for farm families) were found to be…

  19. Students and Instructors Opinions about Piano Instruction

    ERIC Educational Resources Information Center

    Kilic, Deniz Beste Çevik

    2016-01-01

    This study examined the opinions of the students and piano instructors in the Turkish Education Faculties' Fine Arts Instruction Departments' music instruction programs about piano instruction. The study data were collected using a questionnaire administered to the piano instructors and the students who took lessons from them. The study results…

  20. Collaborators' Attitudes about Differences of Opinion.

    ERIC Educational Resources Information Center

    Creamer, Elizabeth G.

    The attitudes of long-term collaborators on research publications about the negotiation of substantive differences of opinion were studied. Long-term collaborators were those who had co-authored publications with another academic for 10 years or more. Multiple sources of data collected from both members of 12 collaborative pairs included…

  1. Opinion and Special Articles: "Physician debtor".

    PubMed

    Scharf, Eugene L; Jones, Lyell K

    2016-01-19

    The increasing cost of attending medical school has contributed to increasing physician indebtedness. The burden of medical school debt has implications for physician career choice, professional satisfaction, and burnout. This opinion discusses the impact of physician indebtedness, the importance of improving debt awareness among neurology trainees, and program- and policy-level solutions to the debt crisis.

  2. Decision-Making When Public Opinion Matters

    ERIC Educational Resources Information Center

    Coppock, Rob

    1977-01-01

    Discusses the impact of public opinion on government decision-making, and develops a model that describes how certain input or control factors can combine to produce discontinuous or divergent policy decisions. Available from: Elsevier Scientific Publishing Company, Box 211, Amsterdam, the Netherlands, single copies available. (Author/JG)

  3. Legal Decisions and Opinions in Pollution Cases

    ERIC Educational Resources Information Center

    Hills, John P.

    1976-01-01

    When dealing with the "frontier of scientific knowledge" and questions of public health, United States courts are waiving traditional burdens of proof, giving increased weight to expert opinions and/or lowering their standard of necessary proof. Recent cases involving asbestos, pesticides, lead in gasoline, and vinyl chlorides are discussed. (BT)

  4. 5 CFR 2636.103 - Advisory opinions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... management policy or directive. Where an employee has actual knowledge or reason to believe that the opinion is based on fraudulent, misleading, or otherwise incorrect information, the employee's reliance on... EARNED INCOME, EMPLOYMENT AND AFFILIATIONS FOR CERTAIN NONCAREER EMPLOYEES General Provisions §...

  5. 5 CFR 2636.103 - Advisory opinions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... management policy or directive. Where an employee has actual knowledge or reason to believe that the opinion is based on fraudulent, misleading, or otherwise incorrect information, the employee's reliance on... EARNED INCOME, EMPLOYMENT AND AFFILIATIONS FOR CERTAIN NONCAREER EMPLOYEES General Provisions §...

  6. 5 CFR 2636.103 - Advisory opinions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... management policy or directive. Where an employee has actual knowledge or reason to believe that the opinion is based on fraudulent, misleading, or otherwise incorrect information, the employee's reliance on... EARNED INCOME, EMPLOYMENT AND AFFILIATIONS FOR CERTAIN NONCAREER EMPLOYEES General Provisions §...

  7. The management education imperative: an opinion.

    PubMed

    Wellever, A L

    1982-01-01

    This article presents an opinion on the need for middle-management education in the four basic functions of management: planning, organizing, directing, and controlling. Using nursing management as an example, the author describes the role of middle management in complex organizations and states that the job of management is to ensure the efficiency and effectiveness of work performed by others.

  8. No Common Opinion on the Common Core

    ERIC Educational Resources Information Center

    Henderson, Michael B.; Peterson, Paul E.; West, Martin R.

    2015-01-01

    According to the three authors of this article, the 2014 "EdNext" poll yields four especially important new findings: (1) Opinion with respect to the Common Core has yet to coalesce. The idea of a common set of standards across the country has wide appeal, and the Common Core itself still commands the support of a majority of the public.…

  9. Cis-Selective Ring-Opening Metathesis Polymerization with Ruthenium Catalysts

    PubMed Central

    Keitz, Benjamin K.; Fedorov, Alexey; Grubbs, Robert H.

    2012-01-01

    Using a C-H activated, ruthenium-based metathesis catalyst, the cis selective ROMP of several monocyclic alkenes, as well as norbornene and oxanorbornene-type monomers is reported. The cis content of the isolated polymers depended heavily on monomer structure and temperature. By lowering the temperature, cis content as high as 96% could be obtained. PMID:22239675

  10. Cluster Ion Spectrometry (CIS) Data Archiving in the CAA

    NASA Astrophysics Data System (ADS)

    Dandouras, I. S.; Barthe, A.; Penou, E.; Brunato, S.; Reme, H.; Kistler, L. M.; Blagau, A.; Facsko, G.; Kronberg, E.; Laakso, H. E.

    2009-12-01

    The Cluster Active Archive (CAA) aims at preserving the four Cluster spacecraft data, so that they are usable in the long-term by the scientific community as well as by the instrument team PIs and Co-Is. This implies that the data are filed together with the descriptive and documentary elements making it possible to select and interpret them. The CIS (Cluster Ion Spectrometry) experiment is a comprehensive ionic plasma spectrometry package onboard the four Cluster spacecraft, capable of obtaining full three-dimensional ion distributions (about 0 to 40 keV/e) with a time resolution of one spacecraft spin (4 sec) and with mass-per-charge composition determination. The CIS package consists of two different instruments, a Hot Ion Analyser (HIA) and a time-of-flight ion Composition Distribution Function (CODIF) analyser. For the archival of the CIS data a multi-level approach has been adopted. The CAA archival includes processed raw data (Level 1 data), moments of the ion distribution functions (Level 2 data), and calibrated high-resolution data in a variety of physical units (Level 3 data). The latter are 3-D ion distribution functions and 2-D pitch-angle distributions. In addition, a software package has been developed to allow the CAA user to interactively calculate partial or total moments of the ion distributions. Instrument cross-calibration has been an important activity in preparing the data for archival. The CIS data archive includes also experiment documentation, graphical products for browsing through the data, and data caveats. In addition, data quality indexes are under preparation, to help the user. Given the complexity of an ion spectrometer, and the variety of its operational modes, each one being optimised for a different magnetospheric region or measurement objective, consultation of the data caveats by the end user will always be a necessary step in the data analysis.

  11. Thermodynamic state ensemble models of cis-regulation.

    PubMed

    Sherman, Marc S; Cohen, Barak A

    2012-01-01

    A major goal in computational biology is to develop models that accurately predict a gene's expression from its surrounding regulatory DNA. Here we present one class of such models, thermodynamic state ensemble models. We describe the biochemical derivation of the thermodynamic framework in simple terms, and lay out the mathematical components that comprise each model. These components include (1) the possible states of a promoter, where a state is defined as a particular arrangement of transcription factors bound to a DNA promoter, (2) the binding constants that describe the affinity of the protein-protein and protein-DNA interactions that occur in each state, and (3) whether each state is capable of transcribing. Using these components, we demonstrate how to compute a cis-regulatory function that encodes the probability of a promoter being active. Our intention is to provide enough detail so that readers with little background in thermodynamics can compose their own cis-regulatory functions. To facilitate this goal, we also describe a matrix form of the model that can be easily coded in any programming language. This formalism has great flexibility, which we show by illustrating how phenomena such as competition between transcription factors and cooperativity are readily incorporated into these models. Using this framework, we also demonstrate that Michaelis-like functions, another class of cis-regulatory models, are a subset of the thermodynamic framework with specific assumptions. By recasting Michaelis-like functions as thermodynamic functions, we emphasize the relationship between these models and delineate the specific circumstances representable by each approach. Application of thermodynamic state ensemble models is likely to be an important tool in unraveling the physical basis of combinatorial cis-regulation and in generating formalisms that accurately predict gene expression from DNA sequence.

  12. Proton irradiation of the CIS115 for the JUICE mission

    NASA Astrophysics Data System (ADS)

    Soman, M. R.; Allanwood, E. A. H.; Holland, A. D.; Winstone, G. P.; Gow, J. P. D.; Stefanov, K.; Leese, M.

    2015-09-01

    The CIS115 is one of the latest CMOS Imaging Sensors designed by e2v technologies, with 1504x2000 pixels on a 7 μm pitch. Each pixel in the array is a pinned photodiode with a 4T architecture, achieving an average dark current of 22 electrons pixel-1 s-1 at 21°C measured in a front-faced device. The sensor aims for high optical sensitivity by utilising e2v's back-thinning and processing capabilities, providing a sensitive silicon thickness approximately 9 μm to 12 μm thick with a tuned anti-reflective coating. The sensor operates in a rolling shutter mode incorporating reset level subtraction resulting in a mean pixel readout noise of 4.25 electrons rms. The full well has been measured to be 34000 electrons in a previous study, resulting in a dynamic range of up to 8000. These performance characteristics have led to the CIS115 being chosen for JANUS, the high-resolution and wide-angle optical camera on the JUpiter ICy moon Explorer (JUICE). The three year science phase of JUICE is in the harsh radiation environment of the Jovian magnetosphere, primarily studying Jupiter and its icy moons. Analysis of the expected radiation environment and shielding levels from the spacecraft and instrument design predict the End Of Life (EOL) displacement and ionising damage for the CIS115 to be equivalent to 1010 10 MeV protons cm-2 and 100 krad(Si) respectively. Dark current and image lag characterisation results following initial proton irradiations are presented, detailing the initial phase of space qualification of the CIS115. Results are compared to the pre-irradiation performance and the instrument specifications and further qualification plans are outlined.

  13. History and Status of the CIS Customs Union

    SciTech Connect

    Lawson, T.M.; Erickson, S.A.

    1999-08-31

    This report explores the history of the CIS Customs Union and the major obstacles the Union faces in its implementation. Investigation of the Customs Union is necessary as its implementation could effect the Second Line of Defense (SLD) Program. Russian Customs contends that radiation detectors should not be installed along the Customs Union members borders of as the borders will be dissolved when the Union is implemented.

  14. City of Troitsk and Sooty Snow, Chelyabinsk, CIS

    NASA Technical Reports Server (NTRS)

    1992-01-01

    This view shows the industrial pollution around the Siberian city of Troitsk (54.0N, 61.0E). Troitsk is the smallest of a group of three heavy industrial cities east of the Urals, the others being Magnitogorsk and Chelyabinsk. All have been cited as being some of the worst industrial polluted cities in the CIS. Despite being the smallest of the three, Troitsk has the largest area of soot blackened snow. Respiratory diseases among the citizens are chronic.

  15. The North American opinion climate for nanotechnology and its products: Opportunities and challenges

    NASA Astrophysics Data System (ADS)

    Priest, Susanna

    2006-10-01

    A January 2005 telephone survey of 1200 people in the U.S. and 2000 Canadians provides a snapshot of current North American opinion regarding nanotechnology at this crucial early point in its emergence from the laboratory to the arena of public discourse and public understanding. Using a typology of "publics" developed through analysis of a previous comparative survey (Priest, S., 2006) and subsequently tested against these newer data (Priest, S., 2005) this article describes the opinion climate for nanotechnology across North America. The comparison of key results from the two countries helps illustrate how social and cultural differences contribute to reactions to new technologies, including nanotech. The article also discusses implications for nanotechnology-related public outreach and risk communication efforts.

  16. Discrepancy and Disliking Do Not Induce Negative Opinion Shifts

    PubMed Central

    Flache, Andreas; Mäs, Michael

    2016-01-01

    Both classical social psychological theories and recent formal models of opinion differentiation and bi-polarization assign a prominent role to negative social influence. Negative influence is defined as shifts away from the opinion of others and hypothesized to be induced by discrepancy with or disliking of the source of influence. There is strong empirical support for the presence of positive social influence (a shift towards the opinion of others), but evidence that large opinion differences or disliking could trigger negative shifts is mixed. We examine positive and negative influence with controlled exposure to opinions of other individuals in one experiment and with opinion exchange in another study. Results confirm that similarities induce attraction, but results do not support that discrepancy or disliking entails negative influence. Instead, our findings suggest a robust positive linear relationship between opinion distance and opinion shifts. PMID:27333160

  17. Cis-elements governing trinucleotide repeat instability in Saccharomyces cerevisiae.

    PubMed Central

    Rolfsmeier, M L; Dixon, M J; Pessoa-Brandão, L; Pelletier, R; Miret, J J; Lahue, R S

    2001-01-01

    Trinucleotide repeat (TNR) instability in humans is governed by unique cis-elements. One element is a threshold, or minimal repeat length, conferring frequent mutations. Since thresholds have not been directly demonstrated in model systems, their molecular nature remains uncertain. Another element is sequence specificity. Unstable TNR sequences are almost always CNG, whose hairpin-forming ability is thought to promote instability by inhibiting DNA repair. To understand these cis-elements further, TNR expansions and contractions were monitored by yeast genetic assays. A threshold of approximately 15--17 repeats was observed for CTG expansions and contractions, indicating that thresholds function in organisms besides humans. Mutants lacking the flap endonuclease Rad27p showed little change in the expansion threshold, suggesting that this element is not altered by the presence or absence of flap processing. CNG or GNC sequences yielded frequent mutations, whereas A-T rich sequences were substantially more stable. This sequence analysis further supports a hairpin-mediated mechanism of TNR instability. Expansions and contractions occurred at comparable rates for CTG tract lengths between 15 and 25 repeats, indicating that expansions can comprise a significant fraction of mutations in yeast. These results indicate that several unique cis-elements of human TNR instability are functional in yeast. PMID:11290713

  18. Cis and trans interactions between atlastin molecules during membrane fusion

    PubMed Central

    Liu, Tina Y.; Bian, Xin; Romano, Fabian B.; Shemesh, Tom; Rapoport, Tom A.; Hu, Junjie

    2015-01-01

    Atlastin (ATL), a membrane-anchored GTPase that mediates homotypic fusion of endoplasmic reticulum (ER) membranes, is required for formation of the tubular network of the peripheral ER. How exactly ATL mediates membrane fusion is only poorly understood. Here we show that fusion is preceded by the transient tethering of ATL-containing vesicles caused by the dimerization of ATL molecules in opposing membranes. Tethering requires GTP hydrolysis, not just GTP binding, because the two ATL molecules are pulled together most strongly in the transition state of GTP hydrolysis. Most tethering events are futile, so that multiple rounds of GTP hydrolysis are required for successful fusion. Supported lipid bilayer experiments show that ATL molecules sitting on the same (cis) membrane can also undergo nucleotide-dependent dimerization. These results suggest that GTP hydrolysis is required to dissociate cis dimers, generating a pool of ATL monomers that can dimerize with molecules on a different (trans) membrane. In addition, tethering and fusion require the cooperation of multiple ATL molecules in each membrane. We propose a comprehensive model for ATL-mediated fusion that takes into account futile tethering and competition between cis and trans interactions. PMID:25825753

  19. Cis-Active RNA Elements (CREs) and Picornavirus RNA Replication

    PubMed Central

    Steil, Benjamin P.; Barton, David J.

    2009-01-01

    Our understanding of picornavirus RNA replication has improved over the past 10 years, due in large part to the discovery of cis-active RNA elements (CREs) within picornavirus RNA genomes. CREs function as templates for the conversion of VPg, the Viral Protein of the genome, into VPgpUpUOH. These so called CREs are different from the previously recognized cis-active RNA sequences and structures within the 5′ and 3′ NTRs of picornavirus genomes. Two adenosine residues in the loop of the CRE RNA structures allow the viral RNA-dependent RNA polymerase 3DPol to add two uridine residues to the tyrosine residue of VPg. Because VPg and/or VPgpUpUOH prime the initiation of viral RNA replication, the asymmetric replication of viral RNA could not be explained without an understanding of the viral RNA template involved in the conversion of VPg into VPgpUpUOH primers. We review the growing body of knowledge regarding picornavirus CREs and discuss how CRE RNAs work coordinately with viral replication proteins and other cis-active RNAs in the 5′ and 3′ NTRs during RNA replication. PMID:18773930

  20. Chaotic Modes in Scale Free Opinion Networks

    NASA Astrophysics Data System (ADS)

    Kusmartsev, Feo V.; Kürten, Karl E.

    2010-12-01

    In this paper, we investigate processes associated with formation of public opinion in varies directed random, scale free and small-world social networks. The important factor of the opinion formation is the existence of contrarians which were discovered by Granovetter in various social psychology experiments1,2,3 long ago and later introduced in sociophysics by Galam.4 When the density of contrarians increases the system behavior drastically changes at some critical value. At high density of contrarians the system can never arrive to a consensus state and periodically oscillates with different periods depending on specific structure of the network. At small density of the contrarians the behavior is manifold. It depends primary on the initial state of the system. If initially the majority of the population agrees with each other a state of stable majority may be easily reached. However when originally the population is divided in nearly equal parts consensus can never be reached. We model the emergence of collective decision making by considering N interacting agents, whose opinions are described by two state Ising spin variable associated with YES and NO. We show that the dynamical behaviors are very sensitive not only to the density of the contrarians but also to the network topology. We find that a phase of social chaos may arise in various dynamical processes of opinion formation in many realistic models. We compare the prediction of the theory with data describing the dynamics of the average opinion of the USA population collected on a day-by-day basis by varies media sources during the last six month before the final Obama-McCain election. The qualitative ouctome is in reasonable agreement with the prediction of our theory. In fact, the analyses of these data made within the paradigm of our theory indicates that even in this campaign there were chaotic elements where the public opinion migrated in an unpredictable chaotic way. The existence of such a phase

  1. Chaotic Modes in Scale Free Opinion Networks

    NASA Astrophysics Data System (ADS)

    Kusmartsev, Feo V.; Kürten, Karl E.

    In this paper, we investigate processes associated with formation of public opinion in varies directed random, scale free and small-world social networks. The important factor of the opinion formation is the existence of contrarians which were discovered by Granovetter in various social psychology experiments1,2,3 long ago and later introduced in sociophysics by Galam.4 When the density of contrarians increases the system behavior drastically changes at some critical value. At high density of contrarians the system can never arrive to a consensus state and periodically oscillates with different periods depending on specific structure of the network. At small density of the contrarians the behavior is manifold. It depends primary on the initial state of the system. If initially the majority of the population agrees with each other a state of stable majority may be easily reached. However when originally the population is divided in nearly equal parts consensus can never be reached. We model the emergence of collective decision making by considering N interacting agents, whose opinions are described by two state Ising spin variable associated with YES and NO. We show that the dynamical behaviors are very sensitive not only to the density of the contrarians but also to the network topology. We find that a phase of social chaos may arise in various dynamical processes of opinion formation in many realistic models. We compare the prediction of the theory with data describing the dynamics of the average opinion of the USA population collected on a day-by-day basis by varies media sources during the last six month before the final Obama-McCain election. The qualitative ouctome is in reasonable agreement with the prediction of our theory. In fact, the analyses of these data made within the paradigm of our theory indicates that even in this campaign there were chaotic elements where the public opinion migrated in an unpredictable chaotic way. The existence of such a phase

  2. 12 CFR 211.11 - Advisory opinions under Regulation K.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 2 2010-01-01 2010-01-01 false Advisory opinions under Regulation K. 211.11... INTERNATIONAL BANKING OPERATIONS (REGULATION K) International Operations of U.S. Banking Organizations § 211.11 Advisory opinions under Regulation K. (a) Request for advisory opinion. Any person may submit a request...

  3. 42 CFR 1008.59 - Range of the advisory opinion.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 5 2014-10-01 2014-10-01 false Range of the advisory opinion. 1008.59 Section 1008.59 Public Health OFFICE OF INSPECTOR GENERAL-HEALTH CARE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OIG AUTHORITIES ADVISORY OPINIONS BY THE OIG Scope and Effect of OIG Advisory Opinions § 1008.59 Range of...

  4. 42 CFR 1008.59 - Range of the advisory opinion.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 5 2011-10-01 2011-10-01 false Range of the advisory opinion. 1008.59 Section 1008.59 Public Health OFFICE OF INSPECTOR GENERAL-HEALTH CARE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OIG AUTHORITIES ADVISORY OPINIONS BY THE OIG Scope and Effect of OIG Advisory Opinions § 1008.59 Range of...

  5. 42 CFR 1008.59 - Range of the advisory opinion.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 5 2012-10-01 2012-10-01 false Range of the advisory opinion. 1008.59 Section 1008.59 Public Health OFFICE OF INSPECTOR GENERAL-HEALTH CARE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OIG AUTHORITIES ADVISORY OPINIONS BY THE OIG Scope and Effect of OIG Advisory Opinions § 1008.59 Range of...

  6. 42 CFR 1008.59 - Range of the advisory opinion.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 5 2013-10-01 2013-10-01 false Range of the advisory opinion. 1008.59 Section 1008.59 Public Health OFFICE OF INSPECTOR GENERAL-HEALTH CARE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OIG AUTHORITIES ADVISORY OPINIONS BY THE OIG Scope and Effect of OIG Advisory Opinions § 1008.59 Range of...

  7. 42 CFR 1008.59 - Range of the advisory opinion.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 5 2010-10-01 2010-10-01 false Range of the advisory opinion. 1008.59 Section 1008.59 Public Health OFFICE OF INSPECTOR GENERAL-HEALTH CARE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OIG AUTHORITIES ADVISORY OPINIONS BY THE OIG Scope and Effect of OIG Advisory Opinions § 1008.59 Range of...

  8. 28 CFR 80.8 - Attorney General opinion.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Attorney General opinion. 80.8 Section 80.8 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) FOREIGN CORRUPT PRACTICES ACT OPINION PROCEDURE § 80.8 Attorney General opinion. The Attorney General or his designee shall, within 30 days...

  9. 29 CFR 18.610 - Religious beliefs or opinions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 1 2010-07-01 2010-07-01 true Religious beliefs or opinions. 18.610 Section 18.610 Labor... OFFICE OF ADMINISTRATIVE LAW JUDGES Rules of Evidence Witnesses § 18.610 Religious beliefs or opinions. Evidence of the beliefs or opinions of a witness on matters of religion is not admissible for the...

  10. 29 CFR 18.610 - Religious beliefs or opinions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 1 2011-07-01 2011-07-01 false Religious beliefs or opinions. 18.610 Section 18.610 Labor... OFFICE OF ADMINISTRATIVE LAW JUDGES Rules of Evidence Witnesses § 18.610 Religious beliefs or opinions. Evidence of the beliefs or opinions of a witness on matters of religion is not admissible for the...

  11. Opinion Dynamics with Heterogeneous Interactions and Information Assimilation

    ERIC Educational Resources Information Center

    Mir Tabatabaei, Seydeh Anahita

    2013-01-01

    In any modern society, individuals interact to form opinions on various topics, including economic, political, and social aspects. Opinions evolve as the result of the continuous exchange of information among individuals and of the assimilation of information distributed by media. The impact of individuals' opinions on each other forms a network,…

  12. Phase Transition in Opinion Diffusion in Social Networks

    DTIC Science & Technology

    2012-05-01

    the opinions of social agents diffuse in a network under a so-called hard-interaction model, in which the agents inter- act more strongly with...gent behavior. Index Terms— opinion diffusion , opinion dynamics, social net- works, phase transition, herding. 1. INTRODUCTION The study of the

  13. 32 CFR 1698.8 - Effect of advisory opinion.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 6 2013-07-01 2013-07-01 false Effect of advisory opinion. 1698.8 Section 1698.8 National Defense Other Regulations Relating to National Defense SELECTIVE SERVICE SYSTEM ADVISORY OPINIONS § 1698.8 Effect of advisory opinion. The Selective Service System will not take action...

  14. 10 CFR 590.404 - Final opinions and orders.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Final opinions and orders. 590.404 Section 590.404 Energy DEPARTMENT OF ENERGY (CONTINUED) NATURAL GAS (ECONOMIC REGULATORY ADMINISTRATION) ADMINISTRATIVE PROCEDURES WITH RESPECT TO THE IMPORT AND EXPORT OF NATURAL GAS Opinions and Orders § 590.404 Final opinions...

  15. 10 CFR 590.404 - Final opinions and orders.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Final opinions and orders. 590.404 Section 590.404 Energy DEPARTMENT OF ENERGY (CONTINUED) NATURAL GAS (ECONOMIC REGULATORY ADMINISTRATION) ADMINISTRATIVE PROCEDURES WITH RESPECT TO THE IMPORT AND EXPORT OF NATURAL GAS Opinions and Orders § 590.404 Final opinions...

  16. 42 CFR 1008.15 - Facts subject to advisory opinions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 5 2010-10-01 2010-10-01 false Facts subject to advisory opinions. 1008.15 Section... Requesting Party § 1008.15 Facts subject to advisory opinions. (a) The OIG will consider requests from a requesting party for advisory opinions regarding the application of specific facts to the subject matters...

  17. 42 CFR 1008.15 - Facts subject to advisory opinions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 5 2011-10-01 2011-10-01 false Facts subject to advisory opinions. 1008.15 Section... Requesting Party § 1008.15 Facts subject to advisory opinions. (a) The OIG will consider requests from a requesting party for advisory opinions regarding the application of specific facts to the subject matters...

  18. PreCisIon: PREdiction of CIS-regulatory elements improved by gene’s positION

    PubMed Central

    Elati, Mohamed; Nicolle, Rémy; Junier, Ivan; Fernández, David; Fekih, Rim; Font, Julio; Képès, François

    2013-01-01

    Conventional approaches to predict transcriptional regulatory interactions usually rely on the definition of a shared motif sequence on the target genes of a transcription factor (TF). These efforts have been frustrated by the limited availability and accuracy of TF binding site motifs, usually represented as position-specific scoring matrices, which may match large numbers of sites and produce an unreliable list of target genes. To improve the prediction of binding sites, we propose to additionally use the unrelated knowledge of the genome layout. Indeed, it has been shown that co-regulated genes tend to be either neighbors or periodically spaced along the whole chromosome. This study demonstrates that respective gene positioning carries significant information. This novel type of information is combined with traditional sequence information by a machine learning algorithm called PreCisIon. To optimize this combination, PreCisIon builds a strong gene target classifier by adaptively combining weak classifiers based on either local binding sequence or global gene position. This strategy generically paves the way to the optimized incorporation of any future advances in gene target prediction based on local sequence, genome layout or on novel criteria. With the current state of the art, PreCisIon consistently improves methods based on sequence information only. This is shown by implementing a cross-validation analysis of the 20 major TFs from two phylogenetically remote model organisms. For Bacillus subtilis and Escherichia coli, respectively, PreCisIon achieves on average an area under the receiver operating characteristic curve of 70 and 60%, a sensitivity of 80 and 70% and a specificity of 60 and 56%. The newly predicted gene targets are demonstrated to be functionally consistent with previously known targets, as assessed by analysis of Gene Ontology enrichment or of the relevant literature and databases. PMID:23241390

  19. 2012 mba.com Prospective Students Survey. Survey Report. The GMAC[R] Survey Series

    ERIC Educational Resources Information Center

    Schoenfeld, Gregg

    2012-01-01

    This 2012 mba.com Prospective Students Survey Report explores the motivations, behaviors, program choices, and intended career outcomes of individuals who expressed a desire to further their education in a graduate business program. More than 16,000 prospective business school students who registered on mba.com shared their opinions, preferences,…

  20. Californians & Higher Education. PPIC Statewide Survey

    ERIC Educational Resources Information Center

    Baldassare, Mark; Bonner, Dean; Petek, Sonja; Shrestha, Jui

    2011-01-01

    This survey was conducted with funding from The James Irvine Foundation. Its goal is to inform state policymakers, encourage discussion, and raise public awareness about Californians' opinions on issues affecting the state's public colleges and universities. It is the fifth annual PPIC (Public Policy Institute of California) Statewide Survey on…

  1. Teaching the Survey Non-Traditional Style

    ERIC Educational Resources Information Center

    Eichhorn, Niels

    2013-01-01

    Teaching survey courses at the university level can be a difficult task. The vast majority of students have to take survey classes as part of their curriculum and, as a result, bring a fair amount of resentment and/or ambivalence with them. Furthermore, many students already arrive on campus with negative opinions about history classes. This…

  2. Dental students' opinions of preparation assessment with E4D compare software versus traditional methods.

    PubMed

    Hamil, Lindsey M; Mennito, Anthony S; Renné, Walter G; Vuthiganon, Jompobe

    2014-10-01

    The aim of this study was to evaluate dental students' opinions regarding the utilization of a new grading software program for student self-assessment and a faculty-grading tool in a preclinical course. Using surface mapping technology, this program, called E4D Compare, yields a digital model of a student's preparation that is color-coded to show deficient areas. The program has now been used for two years at the James B. Edwards College of Dental Medicine at the Medical University of South Carolina, and the students previously assessed with E4D Compare have now entered into the dental clinics. For this study, students were asked to complete an anonymous survey for the investigators to evaluate students' attitudes and opinions on the effectiveness of this software in their preclinical courses to determine if this type of feedback helped them develop clinical skills. The survey also sought to collect students' opinions on the traditional objective criteria-based grading system. The survey was distributed to all members of the Classes of 2014 and 2015; it yielded a 59 percent response rate for the two classes, with a total of eighty-one students responding. Overall, the majority of students preferred the E4D Compare grading system over traditional hand-grading methods. The grading system provided instant, objective, and visual feedback that allowed students to easily see where their deficiencies were and encouraged them to work towards an ideal final product.

  3. Testing for Correlation between Two Journal Ranking Methods: A Comparison of Citation Rankings and Expert Opinion Rankings.

    ERIC Educational Resources Information Center

    Russell, Robert Lowell, Jr.

    This study tests for correlation between two journal ranking methods--citation rankings and expert opinion surveys. Political science professors from four major universities were asked to rank a list of the 20 most highly cited political science journals. Citation data were taken from the "Social Sciences Citation Index Journal Citation…

  4. Apprentices' and Trainees' English Language and Literacy Skills in Workplace Learning and Performance: Employer and Employee Opinion. Australian Apprenticeships.

    ERIC Educational Resources Information Center

    O'Neill, Shirley; Gish, Annabelle

    A study investigated ways employers and their apprentices and trainees perceive how these employees' English language and literacy (ELL) skills affect their learning and performance in the workplace in the current context of New Apprenticeships. The research design and methodology involved sending an opinion survey to a stratified random sample of…

  5. The Opinions of the Teacher Candidates Who Attended the Pedagogical Formation Certificate Programme for the Professional Competency of Instructors

    ERIC Educational Resources Information Center

    Sahin, Mehmet

    2013-01-01

    The main purpose of this study was to determine the opinions of the teacher candidates who attend the pedagogical formation certificate programme for the professional competency of instructors. The method of the research is a descriptive survey based on scanning. The study group included the teacher candidates who attend the pedagogical formation…

  6. Principals' Opinions on the Role of Speech-Language Pathologists Serving Students with Communication Disorders Involved in Violence

    ERIC Educational Resources Information Center

    Ritzman, Mitzi J.; Sanger, Dixie

    2007-01-01

    Purpose: The purpose of this study was to survey the opinions of principals concerning the role of speech-language pathologists (SLPs) serving students with communication disorders who have been involved in violence. Method: A mixed methods design involving 678 questionnaires was mailed to elementary, middle, and high school principals in a…

  7. ETI, SETI and today's public opinion

    NASA Astrophysics Data System (ADS)

    Pinotti, Roberto

    During the last three decades the general public's initial opinions about ETI and SETI changed, turning ignorance, fear and superficiality into a gradual understanding of the importance of these concepts. After a brief analysis of this changing psycho-sociological attitude, the paper provides an "estimate of the situation" about general interest for ETI and SETI, suggesting a growing awareness in today's public opinion. Science fiction movies like Close Encounters of the Third Kind and E.T. the Extra-Terrestrial and popular interest in UFOs as visitors from outer space played a major role in the average man's acceptance of the reality of extra-terrestrial life and its meaning for mankind.

  8. A teledentistry system for the second opinion.

    PubMed

    Gambino, Orazio; Lima, Fausto; Pirrone, Roberto; Ardizzone, Edoardo; Campisi, Giuseppina; di Fede, Olga

    2014-01-01

    In this paper we present a Teledentistry system aimed to the Second Opinion task. It make use of a particular camera called intra-oral camera, also called dental camera, in order to perform the photo shooting and real-time video of the inner part of the mouth. The pictures acquired by the Operator with such a device are sent to the Oral Medicine Expert (OME) by means of a current File Transfer Protocol (FTP) service and the real-time video is channeled into a video streaming thanks to the VideoLan client/server (VLC) application. It is composed by a HTML5 web-pages generated by PHP and allows to perform the Second Opinion both when Operator and OME are logged and when one of them is offline.

  9. Agent Argumentation with Opinions and Advice

    NASA Astrophysics Data System (ADS)

    Debenham, John; Sierra, Carles

    In argumentation-based negotiation the rhetorical illocutionary particles Appeals, Rewards and Threats have implications for the players that extend beyond a single negotiation and are concerned with building (business) relationships. This paper extends an agent's relationship-building argumentative repertoire with Opinions and Advice. A framework is described that enables agents to model their relationships and to use argumentative dialogue strategically both to achieve good negotiation outcomes and to build and sustain valuable relationships.

  10. Enantioselective disruption of the endocrine system by Cis-Bifenthrin in the male mice.

    PubMed

    Jin, Yuanxiang; Wang, Jiangcong; Pan, Xiuhong; Miao, Wenyu; Lin, Xiaojian; Wang, Linggang; Fu, Zhengwei

    2015-07-01

    Bifenthrin (BF), as a chiral pyrethroid, is widely used to control field and household pests in China. At present, the commercial BF is a mixed compound containing cis isomers (cis-BF) including two enantiomers of 1R-cis-BF and 1S-cis-BF. In the present study, the two individual cis-BF enantiomers were separated by a preparative supercritical fluid chromatography. Then, four week-old adolescent male ICR mice were orally administered 1R-cis-BF and 1S-cis-BF separately daily for 3 weeks at doses of 0, 7.5 and 15 mg/kg/day, respectively. Results showed that the transcription status of some genes involved in cholesterol synthesis and transport as well as testosterone (T) synthesis in the testes were influenced by cis-BF enantiomers. Especially, we observed that the transcription status of key genes on the pathway of T synthesis including cytochrome P450 cholesterol side-chain cleavage enzyme (P450scc) and cytochrome P450 17α-hydroxysteroid dehydrogenase (P45017α)) were selectively altered in the testis of mice when treated with 1S-cis-BF, suggesting that it is the possible reason to explain why the lower serum T concentration in 1S-cis-BF treated group. Taken together, it concluded that both of the cis-BF enantiomers have the endocrine disruption activities, while 1S-cis-BF was higher than 1R-cis-BF in mice when exposed during the puberty. The data was helpful to understand the toxicity of cis-BF in mammals under enantiomeric level.

  11. The legislation of CIS countries on the issue of genetically modified products.

    PubMed

    Mammadov, Vugar; Mustafayeva, Aytan

    2011-12-01

    Genetic engineering is a fast-moving research field that produces many achievements, including genetically modified organisms, which are used during the production of food products. Recent decades have shown that scientists, policy makers and the general public cannot reach a consensus about the benefits and hazards of genetically modified food products. Opinions are so different, and both sides are so well-grounded, that it is not easy to reach a conclusion about this scientific achievement. Nevertheless, food security is one of the main objectives of the state, which is responsible for providing safe food products to its own citizens in the marketplace. This is why states are interested in reviewing these scientific achievements, in terms of the state's national interests and the security of its citizens. This article sets forth: (1) the main advantages and disadvantages of genetically modified products; (2) the role of national legislation in the control of food security; and (3) the attitude toward genetically modified products in the national legislatures of CIS countries. Taking these points into account, the authors come to the conclusion that actual Azerbaijan law is not responding to the changes, which have taken place in recent decades, in development of the world market and technological conditions in the production of food products. This provides the basis to conclude that, in actual conditions, the rights ofAzerbaijan citizens to the safety of food products are not well protected. At the end of this article, the authors make recommendations about the necessity of amendments to the legislation in their own country, towards the goal of greater control over such products in Azerbaijan.

  12. On the control of opinion dynamics in social networks

    NASA Astrophysics Data System (ADS)

    Liu, Zhihong; Ma, Jianfeng; Zeng, Yong; Yang, Li; Huang, Qiping; Wu, Hongliang

    2014-09-01

    This paper presents a framework to analyze the controllability of opinion dynamics in social networks using DeGroot model (DeGroot, 1974). We show how the opinion, or attitude about some common questions of interest in a population can be controlled by a committed node who consistently proselytizes the opposing opinion and is immune to influence. Some criteria are established to guarantee that opinion dynamics of networks can be perfectly or partially controlled. We also find that the opinion fluctuation is determined by the smallest negative eigenvalue of an influence matrix.

  13. Metal-organic frameworks from copper dimers with cis- and trans-1,4-cyclohexanedicarboxylate and cis,cis-1,3,5-cyclohexanetricarboxylate.

    PubMed

    Kumagai, Hitoshi; Akita-Tanaka, Motoko; Inoue, Katsuya; Takahashi, Kazuyuki; Kobayashi, Hayao; Vilminot, Serge; Kurmoo, Mohamedally

    2007-07-23

    Single crystals of three coordination networks containing the Cu(2)(COO)(4) core bridged by cyclohexane have been hydrothermally prepared by the reaction of 1,4-cyclohexanedicarboxylic (1,4-H(2)chdc) or 1,3,5-cyclohexanetricarboxylic (1,3,5-H(3)chtc) acid and Cu(NO(3))(2) x 6H(2)O. We report their characterizations by single-crystal X-ray structure determinations, IR spectroscopy, thermal analyses, and their magnetic properties. [Cu(2)(trans-1,4-chdc)(2)] (1) consists of 4 x 4 grids with the dimeric nodes connected by the trans-1,4-chdc, and these grids are then connected to each other by Cu-O bonds, resulting in a porous network (void volume of 130 Angstrom(3) per cell or 25%) with no solvent in its cavities. [Cu(2)(cis-1,4-chdc)(2)(H(2)O)(2)] (2) consists of two-legged ladders where the dimer nodes are bridged by pairs of cis-1,4-chdc and the water molecules cap the ends of the Cu dimers. [Cu(2)(1,3,5-Hchtc)(2)] (3) displays 4 x 4 grids, but each dimeric node is connected to its neighbors within the same grid by Cu-O bonds to form a layered network which further makes hydrogen-bond interactions with its neighbors. 2 and 3 have compact structures without any space for solvents. IR and DT-TGA confirm the absence of water in the empty channels of 1, while IR shows the presence of both protonated and deprotonated carboxyl groups for 3. The magnetic properties of all three compounds are dominated by the strong Cu-Cu antiferromagnetic interaction resulting in singlet-triplet gaps of 450-500 K.

  14. Alchornea cordifolia seed oil: A rich source of a new C20 epoxide, (+)cis-14,15-epoxy-cis-11-eicosenoic acid.

    PubMed

    Kleiman, R; Plattner, R D; Spencer, G F

    1977-07-01

    A C20 homolog of vernolic acid has been found at the 50% level inAlchornea cordifolia, Euphorbiaceae, seed oil. This new acid, (+)cis-14,15-epoxy-cis-11-eicosenoic (alchornoic) acid, was isolated by high-pressure liquid chromotography and characterized by mass spectrometry, nuclear magnetic resonance and infrared spectroscopy, optical rotary dispersion, and ozonolysis-gas-chromotography.

  15. 21 CFR 573.637 - Methyl esters of conjugated linoleic acid (cis-9, trans-11 and trans-10, cis-12-octadecadienoic...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... contain not less than 35 percent of other fatty acid esters composed of oleic acid, palmitic acid, stearic... 21 Food and Drugs 6 2013-04-01 2013-04-01 false Methyl esters of conjugated linoleic acid (cis-9, trans-11 and trans-10, cis-12-octadecadienoic acids). 573.637 Section 573.637 Food and Drugs FOOD...

  16. OpinionSeer: interactive visualization of hotel customer feedback.

    PubMed

    Wu, Yingcai; Wei, Furu; Liu, Shixia; Au, Norman; Cui, Weiwei; Zhou, Hong; Qu, Huamin

    2010-01-01

    The rapid development of Web technology has resulted in an increasing number of hotel customers sharing their opinions on the hotel services. Effective visual analysis of online customer opinions is needed, as it has a significant impact on building a successful business. In this paper, we present OpinionSeer, an interactive visualization system that could visually analyze a large collection of online hotel customer reviews. The system is built on a new visualization-centric opinion mining technique that considers uncertainty for faithfully modeling and analyzing customer opinions. A new visual representation is developed to convey customer opinions by augmenting well-established scatterplots and radial visualization. To provide multiple-level exploration, we introduce subjective logic to handle and organize subjective opinions with degrees of uncertainty. Several case studies illustrate the effectiveness and usefulness of OpinionSeer on analyzing relationships among multiple data dimensions and comparing opinions of different groups. Aside from data on hotel customer feedback, OpinionSeer could also be applied to visually analyze customer opinions on other products or services.

  17. Assessing the Tongzhi Label: Self-Identification and Public Opinion.

    PubMed

    Lau, Holning; Yeung, Geoffrey; Stotzer, Rebecca L; Lau, Charles Q; Loper, Kelley

    2017-01-01

    Tongzhi is one of several Chinese terms that refer to individuals who are attracted to the same sex. Using data from two different surveys in Hong Kong, this research note examines how the term tongzhi coexists with other terms. We investigate the prevalence of self-identification as tongzhi, and we explore the extent to which using the term tongzhi influences public attitudes toward gay people and gay rights. Activists began popularizing the term tongzhi in the late 1980s, but less than one third of the participants in our 2008 survey of sexual orientation minorities (n = 728) described themselves as tongzhi. Using a split-ballot experiment in a 2013 public opinion poll (n = 831), we found that attitudes toward gay people and gay rights were not significantly impacted by whether questions were phrased in terms of tongzhi or the main alternative term tongxinglianzhe. We discuss how our findings can enrich understandings of earlier research and illuminate avenues for future study.

  18. Perioperative care in colorectal surgery: current practice patterns and opinions.

    PubMed

    Roig, J V; García-Fadrique, A; Redondo, C; Villalba, F L; Salvador, A; García-Armengol, J

    2009-11-01

    Objective Evidence regarding perioperative care in colorectal surgery has recently increased, leading to changes in classical clinical procedures that make the perioperative period safer and shorter. This survey aimed to evaluate the opinions of Spanish colorectal surgeons on the perioperative management of their patients. Method Emailed surveys submitted to the members of Spanish Coloproctological Associations. Results One hundred and thirty-one (31.7%) of the 413 members participated in the study and responded thus: 21% use clinical pathways and 8% use fast track (FT); 36% use epidural analgesia in colonic surgery and 57% in rectal; 40% use warm air and 23% warm fluids to maintain intraoperative normothermia; 53% prescribe >/= 3000 ml. of iv fluids on the first postoperative day and 6.2%

  19. PageRank model of opinion formation on social networks

    NASA Astrophysics Data System (ADS)

    Kandiah, Vivek; Shepelyansky, Dima L.

    2012-11-01

    We propose the PageRank model of opinion formation and investigate its rich properties on real directed networks of the Universities of Cambridge and Oxford, LiveJournal, and Twitter. In this model, the opinion formation of linked electors is weighted with their PageRank probability. Such a probability is used by the Google search engine for ranking of web pages. We find that the society elite, corresponding to the top PageRank nodes, can impose its opinion on a significant fraction of the society. However, for a homogeneous distribution of two opinions, there exists a bistability range of opinions which depends on a conformist parameter characterizing the opinion formation. We find that the LiveJournal and Twitter networks have a stronger tendency to a totalitarian opinion formation than the university networks. We also analyze the Sznajd model generalized for scale-free networks with the weighted PageRank vote of electors.

  20. Non-consensus Opinion Models on Complex Networks

    NASA Astrophysics Data System (ADS)

    Li, Qian; Braunstein, Lidia A.; Wang, Huijuan; Shao, Jia; Stanley, H. Eugene; Havlin, Shlomo

    2013-04-01

    Social dynamic opinion models have been widely studied to understand how interactions among individuals cause opinions to evolve. Most opinion models that utilize spin interaction models usually produce a consensus steady state in which only one opinion exists. Because in reality different opinions usually coexist, we focus on non-consensus opinion models in which above a certain threshold two opinions coexist in a stable relationship. We revisit and extend the non-consensus opinion (NCO) model introduced by Shao et al. (Phys. Rev. Lett. 103:01870, 2009). The NCO model in random networks displays a second order phase transition that belongs to regular mean field percolation and is characterized by the appearance (above a certain threshold) of a large spanning cluster of the minority opinion. We generalize the NCO model by adding a weight factor W to each individual's original opinion when determining their future opinion (NCO W model). We find that as W increases the minority opinion holders tend to form stable clusters with a smaller initial minority fraction than in the NCO model. We also revisit another non-consensus opinion model based on the NCO model, the inflexible contrarian opinion (ICO) model (Li et al. in Phys. Rev. E 84:066101, 2011), which introduces inflexible contrarians to model the competition between two opinions in a steady state. Inflexible contrarians are individuals that never change their original opinion but may influence the opinions of others. To place the inflexible contrarians in the ICO model we use two different strategies, random placement and one in which high-degree nodes are targeted. The inflexible contrarians effectively decrease the size of the largest rival-opinion cluster in both strategies, but the effect is more pronounced under the targeted method. All of the above models have previously been explored in terms of a single network, but human communities are usually interconnected, not isolated. Because opinions propagate not

  1. Are Opinions Based on Science: Modelling Social Response to Scientific Facts

    PubMed Central

    Iñiguez, Gerardo; Tagüeña-Martínez, Julia; Kaski, Kimmo K.; Barrio, Rafael A.

    2012-01-01

    As scientists we like to think that modern societies and their members base their views, opinions and behaviour on scientific facts. This is not necessarily the case, even though we are all (over-) exposed to information flow through various channels of media, i.e. newspapers, television, radio, internet, and web. It is thought that this is mainly due to the conflicting information on the mass media and to the individual attitude (formed by cultural, educational and environmental factors), that is, one external factor and another personal factor. In this paper we will investigate the dynamical development of opinion in a small population of agents by means of a computational model of opinion formation in a co-evolving network of socially linked agents. The personal and external factors are taken into account by assigning an individual attitude parameter to each agent, and by subjecting all to an external but homogeneous field to simulate the effect of the media. We then adjust the field strength in the model by using actual data on scientific perception surveys carried out in two different populations, which allow us to compare two different societies. We interpret the model findings with the aid of simple mean field calculations. Our results suggest that scientifically sound concepts are more difficult to acquire than concepts not validated by science, since opposing individuals organize themselves in close communities that prevent opinion consensus. PMID:22905117

  2. Are opinions based on science: modelling social response to scientific facts.

    PubMed

    Iñiguez, Gerardo; Tagüeña-Martínez, Julia; Kaski, Kimmo K; Barrio, Rafael A

    2012-01-01

    As scientists we like to think that modern societies and their members base their views, opinions and behaviour on scientific facts. This is not necessarily the case, even though we are all (over-) exposed to information flow through various channels of media, i.e. newspapers, television, radio, internet, and web. It is thought that this is mainly due to the conflicting information on the mass media and to the individual attitude (formed by cultural, educational and environmental factors), that is, one external factor and another personal factor. In this paper we will investigate the dynamical development of opinion in a small population of agents by means of a computational model of opinion formation in a co-evolving network of socially linked agents. The personal and external factors are taken into account by assigning an individual attitude parameter to each agent, and by subjecting all to an external but homogeneous field to simulate the effect of the media. We then adjust the field strength in the model by using actual data on scientific perception surveys carried out in two different populations, which allow us to compare two different societies. We interpret the model findings with the aid of simple mean field calculations. Our results suggest that scientifically sound concepts are more difficult to acquire than concepts not validated by science, since opposing individuals organize themselves in close communities that prevent opinion consensus.

  3. [Opinions of nursing students about various sexual practices].

    PubMed

    Egry, E Y

    1985-04-01

    This study sought to determine the beliefs of nursing students on human sexuality, their information sources, and persons influencing their opinion. A survey conducted December 1983 to January 1985 targeted female graduating students in Nursing and Obstetrics at the University of Sao Paulo (USP) School of Nursing; its findings were then compared to similar studies conducted among the general population. The findings show that the target population and general population opinions differ little, reflecting fear and prejudice about sexual practices. Also, the professional training of Brazil's nurses failed to include a fundamental understanding of human sexuality. The 42 respondents are characterized as follows: age 21 to 36 years; 95.2% single; 88% childless; 59.5% born in the city of Sao Paulo; 88% born in the state of Sao Paulo; 85.7% with long term residence in urban areas and state capitals; and 92.5% attended 4 years of nursing school at USP. Results showed: 47.6% favored premarital sex; 26.2% espoused premarital virginity for men and 19% for women; roughly 60% disapproved of extramarital relations for both sexes. 75% considered masturbation normal for both sexes; about 90% approved of contraceptive practices for men and women; 90.5% favored family planning; 26% were strictly against abortion; nearly 60% found prostitution unacceptable for both sexes; and homosexuality in both sexes was considered taboo by 42.8%, and acceptable by 14%. The vast majority favored sexual education at all levels. Regarding sources of sexual infomation: books, magazines and encyclopedias comprised 25%; male friends, 10%; girlfriends, 9.4%; boyfriends 8%; and, the University of Sao Paulo School of Nursing, a mere 6.5%. The persons who influenced their opinions were: first, boyfriend (23.7%) followed by mother, girlfriends and male friends; second, girlfriend (28.5%) followed by boyfriend and male friend; third, girlfriend, boyfriend, male friend, and teachers (7.1% each); fourth

  4. Opinion polls and the U.S. civil space program

    NASA Technical Reports Server (NTRS)

    Kraemer, Sylvia K.

    1993-01-01

    The conclusions that can be drawn from public opinion polls depend a great deal on what usually does not appear on the newspaper page or television screen. Subtle biases can result from the population interviewed, the time of day individuals were called, how a particular question was asked, or how the answer was interpreted. Examples are the 1961 Gallop Poll, the survey done for Rockwell International by the firm of Yankelovich, Skelly and White/Clancy Shulman, and the one done by Jon D. Miller of the International Center for the Advancement of Scientific Literacy. There is more to learn from opinion polls than that a good proportion of adult Americans support the space program. We can learn that social and economic security are not competing goals with space, but interdependent goals. If we want to increase public support for space, we must increase the number of Americans who have the economic freedom to take an interest in something besides getting by, day after day. We can also learn that the majority of those who support the space program can distinguish between the bread and circuses of space travel. They are content to experience extraordinary adventures in the movie theaters; for their tax dollars they want real return in expended scientific knowledge and understanding. Finally, we can learn that we need to increase that return, not just for scientific careers, but for the ordinary people who pay our bills and for their children, our children. Ultimately, the space program is for them, as all investments in the future must be.

  5. Genomic approaches to finding cis-regulatory modules in animals

    PubMed Central

    Hardison, Ross C.; Taylor, James

    2012-01-01

    Differential gene expression is the fundamental mechanism underlying animal development and cell differentiation. However, it is a challenge to identify comprehensively and accurately the DNA sequences required to regulate gene expression, called cis-regulatory modules (CRMs). Three major features (singly or in combination) are used to predict CRMs: clusters of transcription-factor binding-site motifs, noncoding DNA under evolutionary constraint, and biochemical marks associated with CRMs, such as histone modifications and protein occupancy. The validation rates for predictions indicate that identifying diagnostic biochemical marks is the most reliable method, and understanding is enhanced by analysis of motifs and conservation patterns within those predicted CRMs. PMID:22705667

  6. cis-clerodane diterpenes from the liverwort Scapania ciliata.

    PubMed

    Liu, Na; Zhu, Rong-Xiu; Wang, Song; Zhang, Jiao-Zhen; Lin, Zhao-Min; Li, Rui-Juan; Lou, Hong-Xiang

    2013-09-01

    Chemical investigation of the Chinese liverwort Scapania ciliata led to the isolation of four new cis-clerodane lactones, named ciliatolides A-D (1-4, resp.), among which compound 1 was found to be a tetranorclerodanoid. Their structures were determined by extensive analysis of spectroscopic data, and, in the case of compound 1, together with a single-crystal X-ray diffraction analysis. The absolute configurations were established by analysis of the CD spectra and by quantum-chemical CD calculations. The cytotoxicities of compounds 1-4 were preliminarily tested against the PC3 and MCF-7 cell lines.

  7. Student Use of and Perspectives Regarding Podcasted Lectures: Survey Pilot

    ERIC Educational Resources Information Center

    Preuss, Michael

    2009-01-01

    As part of a podcasting initiative at a community college, a student survey was developed. This survey was based upon the work of Janossy (2007) and Evans (2008) and addressed student use of, opinions of and preferences regarding podcasted lectures. The development, field test and field test outcomes of the survey instrument are described.…

  8. Latex Clearing Protein—an Oxygenase Cleaving Poly(cis-1,4-Isoprene) Rubber at the cis Double Bonds

    PubMed Central

    Hiessl, Sebastian; Böse, Dietrich; Oetermann, Sylvia; Eggers, Jessica; Pietruszka, Jörg

    2014-01-01

    Gordonia polyisoprenivorans strain VH2, a potent rubber-degrading actinomycete, harbors two latex clearing proteins (Lcps), which are known to be essential for the microbial degradation of rubber. However, biochemical information on the exact role of this protein in the degradation of polyisoprene was lacking. In this study, the gene encoding Lcp1VH2 was heterologously expressed in strains of Escherichia coli, the corresponding protein was purified, and its role in rubber degradation was examined by measurement of oxygen consumption as well as by chromatographic and spectroscopic methods. It turned out that active Lcp1VH2 is a monomer and is responsible for the oxidative cleavage of poly(cis-1,4-isoprene) in synthetic as well as in natural rubber by the addition of oxygen (O2) to the cis double bonds. The resulting oligomers possess repetitive isoprene units with aldehyde (CHO-CH2—) and ketone (—CH2-CO-CH3) functional groups at the termini. Two fractions with average isoprene contents of 18 and 10, respectively, were isolated, thus indicating an endocleavage mechanism. The activity of Lcp1VH2 was determined by applying a polarographic assay. Alkenes, acyclic terpenes, or other rubber-like polymers, such as poly(cis-1,4-butadiene) or poly(trans-1,4-isoprene), are not oxidatively cleaved by Lcp1VH2. The pH and temperature optima of the enzyme are at pH 7 and 30°C, respectively. Furthermore, it was demonstrated that active Lcp1VH2 is a Cu(II)-containing oxygenase that exhibits a conserved domain of unknown function which cannot be detected in any other hitherto-characterized enzyme. The results presented here indicate that this domain might represent a new protein family of oxygenases. PMID:24928880

  9. Latex clearing protein-an oxygenase cleaving poly(cis-1,4-isoprene) rubber at the cis double bonds.

    PubMed

    Hiessl, Sebastian; Böse, Dietrich; Oetermann, Sylvia; Eggers, Jessica; Pietruszka, Jörg; Steinbüchel, Alexander

    2014-09-01

    Gordonia polyisoprenivorans strain VH2, a potent rubber-degrading actinomycete, harbors two latex clearing proteins (Lcps), which are known to be essential for the microbial degradation of rubber. However, biochemical information on the exact role of this protein in the degradation of polyisoprene was lacking. In this study, the gene encoding Lcp1VH2 was heterologously expressed in strains of Escherichia coli, the corresponding protein was purified, and its role in rubber degradation was examined by measurement of oxygen consumption as well as by chromatographic and spectroscopic methods. It turned out that active Lcp1VH2 is a monomer and is responsible for the oxidative cleavage of poly(cis-1,4-isoprene) in synthetic as well as in natural rubber by the addition of oxygen (O2) to the cis double bonds. The resulting oligomers possess repetitive isoprene units with aldehyde (CHO-CH2-) and ketone (-CH2-CO-CH3) functional groups at the termini. Two fractions with average isoprene contents of 18 and 10, respectively, were isolated, thus indicating an endocleavage mechanism. The activity of Lcp1VH2 was determined by applying a polarographic assay. Alkenes, acyclic terpenes, or other rubber-like polymers, such as poly(cis-1,4-butadiene) or poly(trans-1,4-isoprene), are not oxidatively cleaved by Lcp1VH2. The pH and temperature optima of the enzyme are at pH 7 and 30°C, respectively. Furthermore, it was demonstrated that active Lcp1VH2 is a Cu(II)-containing oxygenase that exhibits a conserved domain of unknown function which cannot be detected in any other hitherto-characterized enzyme. The results presented here indicate that this domain might represent a new protein family of oxygenases.

  10. Crystal structure of 1,6-di-thia-cyclo-deca-cis-3,cis-8-diene (DTCDD).

    PubMed

    Baughman, Russell G; Delanty, Molly C; Ortwerth, Michael F

    2014-11-01

    The title compound, C8H12S2 (trivial name DTCDD), was obtained as a side product of the reaction between cis-1,4-di-chloro-but-2-ene and sodium sulfide. The asymmetric unit consists of one-quarter of the mol-ecule (S site symmetry 2) and the complete mol-ecule has 2/m (C 2h ) point symmetry with the C=C bond in an E conformation. The geometry of the title compound is compared to those of a chloro derivative and a mercury complex.

  11. Randomized Subspace Learning for Proline Cis-Trans Isomerization Prediction.

    PubMed

    Al-Jarrah, Omar Y; Yoo, Paul D; Taha, Kamal; Muhaidat, Sami; Shami, Abdallah; Zaki, Nazar

    2015-01-01

    Proline residues are common source of kinetic complications during folding. The X-Pro peptide bond is the only peptide bond for which the stability of the cis and trans conformations is comparable. The cis-trans isomerization (CTI) of X-Pro peptide bonds is a widely recognized rate-limiting factor, which can not only induces additional slow phases in protein folding but also modifies the millisecond and sub-millisecond dynamics of the protein. An accurate computational prediction of proline CTI is of great importance for the understanding of protein folding, splicing, cell signaling, and transmembrane active transport in both the human body and animals. In our earlier work, we successfully developed a biophysically motivated proline CTI predictor utilizing a novel tree-based consensus model with a powerful metalearning technique and achieved 86.58 percent Q2 accuracy and 0.74 Mcc, which is a better result than the results (70-73 percent Q2 accuracies) reported in the literature on the well-referenced benchmark dataset. In this paper, we describe experiments with novel randomized subspace learning and bootstrap seeding techniques as an extension to our earlier work, the consensus models as well as entropy-based learning methods, to obtain better accuracy through a precise and robust learning scheme for proline CTI prediction.

  12. Phase transitions in chlorobenzene-cis-decalin mixtures

    NASA Astrophysics Data System (ADS)

    Mansingh, Abhai; Agarwal, C. B.; Singh, Ramadhar

    1980-01-01

    The dielectric constant ɛ' and loss tangent tan δ of chlorobenzene-cis-decalin mixtures have been measured in the temperature range 77 K to 330 K and frequency range 0.1 to 100 kHz. On cooling, ɛ' increases with decreasing temperature upto about 135 K, after which it drops rapidly with decreasing T followed by a slow decrease. This indicates that the liquid mixture goes to an amorphous phase which transforms to a glass phase of restricted dipole rotation below T g; however, the peak in ɛ' is due to relaxation in the amorphous phase (α relaxation) and does not give an exact T g. On heating, the behaviour of the cooling curve is retraced upto 160 K, after which ɛ' drops suddenly to a value lower than that at 77 K in the glass phase. This indicates the transition to a crystalline phase in which dipole rotational freedom is completely lost. The crystalline phase changes to a eutectic liquid phase of high ɛ' at a temperature (200 K) lower than the melting point of chlorobenzene and cis-decalin. Dielectric dispersion is observed only in the glass and amorphous phases. The dielectric relaxation time is independent of the concentration of chlorobenzene.

  13. Theoretical study of trans-cis photoisomerism in polymethine cyanines

    NASA Astrophysics Data System (ADS)

    Momicchioli, Fabio; Baraldi, Ivan; Berthier, Gaston

    1988-06-01

    The trans-cis photoisomerism of polymethine dyes has been interpreted so far using different and rather inconsistent models of the potential energy surfaces. In order to search for a unified electronic model, we tackled the problem again from an intramolecular point of view. Our study consisted in qualitative MO considerations followed by explicit (CS INDO) calculations of the S 0, T 1 and S 1 potential energy curves for a proper model system: pentamethine cyanine isomerizing around the 2-3 and 3-4 bonds. Torsional energy levels for the calculated potential curves were also obtained. The main conclusions are: (i) the photoreaction proceeds through a "non-spectroscopic" (perp) S 1 minimum which exists also in the isolated molecule, (ii) this twisted excited species has charge transfer character (TICT), as opposed to the biradicaloid character of the "non-spectroscopic" S 1 minimum involved in the trans→cis photoisomerization of olefines (e.g., stilbene). The possible consequences on the dynamics of the excited state relaxation in non-polar solvents are envisaged.

  14. [Synthesis and crystalline structure of cis-monochloro(dimenthylsulfoxide)].

    PubMed

    Bentefrit, F; Viossat, B; Tomas, A; Nguyen Huy, D; Morgant, G

    2002-03-01

    The synthesis of cis-monochloro(dimethylsulfoxide)(metforminuro) platine(II) was investigated. It crystallizes in the monoclinic system, space group P 2(1)/c with Z=4. The cell parameters are: a=9.173(2); b=11.286( 2); c=12.556( 3) (A); b=99.69(2) degrees. The structure of this compound was refined to R=0.031 and wR=0.038 using 1461 independent reflexions with I>3 s(I). The platinum coordination is square planar, built up from one Cl, one O from the dimethylsulfoxide, and one bidentate chelating ligand (metforminure anion) via the two imine nitrogen atoms in cis position. The negative charge of the metforminure ligand ensures the electric neutrality in the complex. The crystal packing is characterized by four hydrogen bonds, one of which is bifurcated (involving Cl atom (intramolecular bonding) and O(i) (intermolecular bonding; symmetry code i: x, 3/2-y; 1/2+z).

  15. The noisy Hegselmann-Krause model for opinion dynamics

    NASA Astrophysics Data System (ADS)

    Pineda, Miguel; Toral, Raúl; Hernández-García, Emilio

    2013-12-01

    In the model for continuous opinion dynamics introduced by Hegselmann and Krause, each individual moves to the average opinion of all individuals within an area of confidence. In this work we study the effects of noise in this system. With certain probability, individuals are given the opportunity to change spontaneously their opinion to another one selected randomly inside the opinion space with different rules. If the random jump does not occur, individuals interact through the Hegselmann-Krause's rule. We analyze two cases, one where individuals can carry out opinion random jumps inside the whole opinion space, and other where they are allowed to perform jumps just inside a small interval centered around the current opinion. We found that these opinion random jumps change the model behavior inducing interesting phenomena. Using pattern formation techniques, we obtain approximate analytical results for critical conditions of opinion cluster formation. Finally, we compare the results of this work with the noisy version of the Deffuant et al. model [G. Deffuant, D. Neu, F. Amblard, G. Weisbuch, Adv. Compl. Syst. 3, 87 (2000)] for continuous-opinion dynamics.

  16. Students’ Opinions on Summative Team Assessments in a Three-Year Concentrated Pharmacy Curriculum

    PubMed Central

    Fasanella, Dana R.; Elfadaly, Marwa

    2016-01-01

    Objective. To investigate student opinions of team assessment. Methods. University of Maryland Eastern Shore School of Pharmacy first-year (P1) to third-year (P3) students (n=125) completed an online survey regarding team assessments. Students rated their opinions on a Likert scale. Responses were examined using Mann-Whitney U test with respect to academic performance and class. Results. One hundred twenty-five students (75%) completed the survey. A majority of students agreed that team assessment was beneficial (90%). In contrast, 78% of the students perceived that the discussion helped clarify misconceptions. Students were not in agreement on occurrence of free riders (51%) and the use of peer evaluation (38%). Overall, students ranked the benefits of team assessment as improving individual score, then promoting collaboration, followed by enhancing understanding of material. Conclusion. Students had favorable opinions regarding team assessment. Educational benefits of team assessments include enhanced understanding of the material, being a meaningful activity for promoting collaboration, and developing communication skills. PMID:27667840

  17. Students' Opinions on Summative Team Assessments in a Three-Year Concentrated Pharmacy Curriculum.

    PubMed

    Tejada, Frederick R; Fasanella, Dana R; Elfadaly, Marwa

    2016-08-25

    Objective. To investigate student opinions of team assessment. Methods. University of Maryland Eastern Shore School of Pharmacy first-year (P1) to third-year (P3) students (n=125) completed an online survey regarding team assessments. Students rated their opinions on a Likert scale. Responses were examined using Mann-Whitney U test with respect to academic performance and class. Results. One hundred twenty-five students (75%) completed the survey. A majority of students agreed that team assessment was beneficial (90%). In contrast, 78% of the students perceived that the discussion helped clarify misconceptions. Students were not in agreement on occurrence of free riders (51%) and the use of peer evaluation (38%). Overall, students ranked the benefits of team assessment as improving individual score, then promoting collaboration, followed by enhancing understanding of material. Conclusion. Students had favorable opinions regarding team assessment. Educational benefits of team assessments include enhanced understanding of the material, being a meaningful activity for promoting collaboration, and developing communication skills.

  18. Genomic analysis reveals major determinants of cis-regulatory variation in Capsella grandiflora

    PubMed Central

    Steige, Kim A.; Laenen, Benjamin; Reimegård, Johan; Slotte, Tanja

    2017-01-01

    Understanding the causes of cis-regulatory variation is a long-standing aim in evolutionary biology. Although cis-regulatory variation has long been considered important for adaptation, we still have a limited understanding of the selective importance and genomic determinants of standing cis-regulatory variation. To address these questions, we studied the prevalence, genomic determinants, and selective forces shaping cis-regulatory variation in the outcrossing plant Capsella grandiflora. We first identified a set of 1,010 genes with common cis-regulatory variation using analyses of allele-specific expression (ASE). Population genomic analyses of whole-genome sequences from 32 individuals showed that genes with common cis-regulatory variation (i) are under weaker purifying selection and (ii) undergo less frequent positive selection than other genes. We further identified genomic determinants of cis-regulatory variation. Gene body methylation (gbM) was a major factor constraining cis-regulatory variation, whereas presence of nearby transposable elements (TEs) and tissue specificity of expression increased the odds of ASE. Our results suggest that most common cis-regulatory variation in C. grandiflora is under weak purifying selection, and that gene-specific functional constraints are more important for the maintenance of cis-regulatory variation than genome-scale variation in the intensity of selection. Our results agree with previous findings that suggest TE silencing affects nearby gene expression, and provide evidence for a link between gbM and cis-regulatory constraint, possibly reflecting greater dosage sensitivity of body-methylated genes. Given the extensive conservation of gbM in flowering plants, this suggests that gbM could be an important predictor of cis-regulatory variation in a wide range of plant species. PMID:28096395

  19. Genomic analysis reveals major determinants of cis-regulatory variation in Capsella grandiflora.

    PubMed

    Steige, Kim A; Laenen, Benjamin; Reimegård, Johan; Scofield, Douglas G; Slotte, Tanja

    2017-01-31

    Understanding the causes of cis-regulatory variation is a long-standing aim in evolutionary biology. Although cis-regulatory variation has long been considered important for adaptation, we still have a limited understanding of the selective importance and genomic determinants of standing cis-regulatory variation. To address these questions, we studied the prevalence, genomic determinants, and selective forces shaping cis-regulatory variation in the outcrossing plant Capsella grandiflora We first identified a set of 1,010 genes with common cis-regulatory variation using analyses of allele-specific expression (ASE). Population genomic analyses of whole-genome sequences from 32 individuals showed that genes with common cis-regulatory variation (i) are under weaker purifying selection and (ii) undergo less frequent positive selection than other genes. We further identified genomic determinants of cis-regulatory variation. Gene body methylation (gbM) was a major factor constraining cis-regulatory variation, whereas presence of nearby transposable elements (TEs) and tissue specificity of expression increased the odds of ASE. Our results suggest that most common cis-regulatory variation in C. grandiflora is under weak purifying selection, and that gene-specific functional constraints are more important for the maintenance of cis-regulatory variation than genome-scale variation in the intensity of selection. Our results agree with previous findings that suggest TE silencing affects nearby gene expression, and provide evidence for a link between gbM and cis-regulatory constraint, possibly reflecting greater dosage sensitivity of body-methylated genes. Given the extensive conservation of gbM in flowering plants, this suggests that gbM could be an important predictor of cis-regulatory variation in a wide range of plant species.

  20. Evaluation of 9-cis retinoic acid and mitotane as antitumoral agents in an adrenocortical xenograft model.

    PubMed

    Nagy, Zoltán; Baghy, Kornélia; Hunyadi-Gulyás, Éva; Micsik, Tamás; Nyírő, Gábor; Rácz, Gergely; Butz, Henriett; Perge, Pál; Kovalszky, Ilona; Medzihradszky, Katalin F; Rácz, Károly; Patócs, Attila; Igaz, Peter

    2015-01-01

    The available drug treatment options for adrenocortical carcinoma (ACC) are limited. In our previous studies, the in vitro activity of 9-cis retinoic acid (9-cisRA) on adrenocortical NCI-H295R cells was shown along with its antitumoral effects in a small pilot xenograft study. Our aim was to dissect the antitumoral effects of 9-cisRA on ACC in a large-scale xenograft study involving mitotane, 9-cisRA and their combination. 43 male SCID mice inoculated with NCI-H295R cells were treated in four groups (i. control, ii. 9-cisRA, iii. mitotane, iv. 9-cisRA + mitotane) for 28 days. Tumor size follow-up, histological and immunohistochemical (Ki-67) analysis, tissue gene expression microarray, quantitative real-time-PCR for the validation of microarray results and to detect circulating microRNAs were performed. Protein expression was studied by proteomics and Western-blot validation. Only mitotane alone and the combination of 9-cisRA and mitotane resulted in significant tumor size reduction. The Ki-67 index was significantly reduced in both 9-cisRA and 9-cisRA+mitotane groups. Only modest changes at the mRNA level were found: the 9-cisRA-induced overexpression of apolipoprotein A4 and down-regulation of phosphodiesterase 4A was validated. The expression of circulating hsa-miR-483-5p was significantly reduced in the combined treatment group. The SET protein was validated as being significantly down-regulated in the combined mitotane+9-cisRA group. 9-cisRA might be a helpful additive agent in the treatment of ACC in combination with mitotane. Circulating hsa-miR-483-5p could be utilized for monitoring the treatment efficacy in ACC patients, and the treatment-induced reduction in protein SET expression might raise its relevance in ACC biology.

  1. Evaluation of 9-cis retinoic acid and mitotane as antitumoral agents in an adrenocortical xenograft model

    PubMed Central

    Nagy, Zoltán; Baghy, Kornélia; Hunyadi-Gulyás, Éva; Micsik, Tamás; Nyírő, Gábor; Rácz, Gergely; Butz, Henriett; Perge, Pál; Kovalszky, Ilona; Medzihradszky, Katalin F; Rácz, Károly; Patócs, Attila; Igaz, Peter

    2015-01-01

    The available drug treatment options for adrenocortical carcinoma (ACC) are limited. In our previous studies, the in vitro activity of 9-cis retinoic acid (9-cisRA) on adrenocortical NCI-H295R cells was shown along with its antitumoral effects in a small pilot xenograft study. Our aim was to dissect the antitumoral effects of 9-cisRA on ACC in a large-scale xenograft study involving mitotane, 9-cisRA and their combination. 43 male SCID mice inoculated with NCI-H295R cells were treated in four groups (i. control, ii. 9-cisRA, iii. mitotane, iv. 9-cisRA + mitotane) for 28 days. Tumor size follow-up, histological and immunohistochemical (Ki-67) analysis, tissue gene expression microarray, quantitative real-time-PCR for the validation of microarray results and to detect circulating microRNAs were performed. Protein expression was studied by proteomics and Western-blot validation. Only mitotane alone and the combination of 9-cisRA and mitotane resulted in significant tumor size reduction. The Ki-67 index was significantly reduced in both 9-cisRA and 9-cisRA+mitotane groups. Only modest changes at the mRNA level were found: the 9-cisRA-induced overexpression of apolipoprotein A4 and down-regulation of phosphodiesterase 4A was validated. The expression of circulating hsa-miR-483-5p was significantly reduced in the combined treatment group. The SET protein was validated as being significantly down-regulated in the combined mitotane+9-cisRA group. 9-cisRA might be a helpful additive agent in the treatment of ACC in combination with mitotane. Circulating hsa-miR-483-5p could be utilized for monitoring the treatment efficacy in ACC patients, and the treatment-induced reduction in protein SET expression might raise its relevance in ACC biology. PMID:26885453

  2. Opinion Spirals, Silent and Otherwise: Applying Small-Group Research to Public Opinion Phenomena (Review Essay).

    ERIC Educational Resources Information Center

    Price, Vincent; Allen, Scott

    1990-01-01

    Reviews E. Noelle-Neumann's "spiral of silence" theory, which holds that, when a person learns through the mass media that public opinion has shifted away from the person's views, that person withdraws from expressing those views. Points to conflicting empirical evidence on Neumann's theory. Summarizes criticisms advanced against the…

  3. Human opinion dynamics: An inspiration to solve complex optimization problems

    PubMed Central

    Kaur, Rishemjit; Kumar, Ritesh; Bhondekar, Amol P.; Kapur, Pawan

    2013-01-01

    Human interactions give rise to the formation of different kinds of opinions in a society. The study of formations and dynamics of opinions has been one of the most important areas in social physics. The opinion dynamics and associated social structure leads to decision making or so called opinion consensus. Opinion formation is a process of collective intelligence evolving from the integrative tendencies of social influence with the disintegrative effects of individualisation, and therefore could be exploited for developing search strategies. Here, we demonstrate that human opinion dynamics can be utilised to solve complex mathematical optimization problems. The results have been compared with a standard algorithm inspired from bird flocking behaviour and the comparison proves the efficacy of the proposed approach in general. Our investigation may open new avenues towards understanding the collective decision making. PMID:24141795

  4. Ideology and opposition to abortion: trends in public opinion, 1972-1980.

    PubMed

    Deitch, C H

    1983-01-01

    Data from the National Opinion Research Center General Social Survey 1972-1980 are examined to determine the extent to which the conflict over legal abortion has come to be associated, in the structure of public opinion, with broader ideological differences concerning sexuality, feminism, and political liberalissm. Specifically, attitudes toward premarital sex, homosexuality, women's roles, liberal versus conservative political self-identification, and views on government spending policies are examined as possible ideological correlates of position on abortion. Log-linear analysis demonstrates that a clear, significant, and persistent association exists between abortion attitude and each of the other 5 issues, independent of religion, education, or sex of the respondent. Furthermore, there is no evidence of any change from 1972 to 1980 in the strength of the association of abortion attitude with any of the other questions considered, despite the increased polarization and politicization of the abortion issue over the time period studied.

  5. Not the next IRA: how health savings accounts shape public opinion.

    PubMed

    Barabas, Jason

    2009-04-01

    Scholars suspect that public policies affect public opinion, but the empirical evidence is mixed, and contemporary theories advance offsetting predictions. This study examines two allegedly similar private investment account programs that differ in politically relevant ways. Statistical analyses show that owners of Individual Retirement Accounts (IRAs) and Health Savings Accounts (HSAs) experience policy feedback effects, but in opposite directions. More specifically, matched comparisons of respondents in a national survey indicate that IRA participants are more likely to favor Social Security privatization than individuals without IRAs. In contrast, HSA participants are less likely to prefer consumer-driven health coverage in which individuals are empowered to make choices. Overall, the findings suggest that policies alter public opinion preferences but that the effects depend on programmatic design and performance.

  6. Anti-tumor Properties of cis-Resveratrol Methylated Analogues in Metastatic Mouse Melanoma Cells

    PubMed Central

    Morris, Valery L.; Toseef, Tayyaba; Nazumudeen, Fathima B.; Rivoira, Christian; Spatafora, Carmela; Tringali, Corrado; Rotenberg, Susan A.

    2015-01-01

    Resveratrol (E-3,5,4’-trihydroxystilbene) is a polyphenol found in red wine that has been shown to have multiple anti-cancer properties. Although cis (Z) and trans (E) isomers of resveratrol occur in nature, the cis form is not biologically active. However, methylation at key positions of the cis form results in more potent anti-cancer properties. This study determined that synthetic cis-polymethoxystilbenes (methylated analogues of cis-resveratrol) inhibited cancer-related phenotypes of metastatic B16 F10 and non-metastatic B16 F1 mouse melanoma cells. In contrast with cis or trans-resveratrol and trans-polymethoxystilbene which were ineffective at 10 μM, cis-polymethoxystilbenes inhibited motility and proliferation of melanoma cells with low micromolar specificity (IC50 <10 μM). Inhibitory effects by cis-polymethoxystilbenes were significantly stronger with B16 F10 cells and were accompanied by decreased expression of β-tubulin and pleckstrin homology domain-interacting protein, a marker of metastatic B16 cells. Thus, cis-polymethoxystilbenes have potential as chemotherapeutic agents for metastatic melanoma. PMID:25567208

  7. Formation of cis-coniferin in cell-free extracts of Fagus grandifolia Ehrh bark

    NASA Technical Reports Server (NTRS)

    Yamamoto, E.; Inciong, E. J.; Davin, L. B.; Lewis, N. G.

    1990-01-01

    American beech (Fagus grandifolia Ehrh) bark exclusively accumulates cis-monolignols and their glucosidic conjugates; no evidence for the accumulation of trans-monolignols has been found. The glucosyltransferase from this source exhibits a very unusual substrate specificity for cis, and not trans, monolignols. This is further evidence that cis monolignols are involved in lignin formation in these plant tissues. Preliminary evidence for the existence of a novel trans-cis monolignol isomerase was obtained, in agreement with our contention that this isomerization is not photochemically mediated.

  8. Enantioselective synthesis of cis-decalins using organocatalysis and sulfonyl Nazarov reagents.

    PubMed

    Peña, Javier; Silveira-Dorta, Gastón; Moro, Rosalina F; Garrido, Narciso M; Marcos, Isidro S; Sanz, Francisca; Díez, David

    2015-04-10

    The first organocatalytic synthesis of cis-decalins using sulfonyl Nazarov reagents is reported. The Jørgensen's catalyst directs this highly enantioselective synthesis using different cyclohexenal derivatives.

  9. Enthalpy of ligand substitution in cis organopalladium complexes with monodentate ligands.

    PubMed

    Salas, Gorka; Casares, Juan A; Espinet, Pablo

    2009-10-21

    The enthalpy for the substitution reaction cis-[PdRf(2)(THF)(2)] + 2 L -->cis-[PdRf(2)L(2)] + 2THF (THF = tetrahydrofuran) has been measured in THF by calorimetric methods for Rf = 3,5-dichloro-2,4,6-trifluorophenyl, L = PPh(3), AsPh(3), SbPh(3), PMePh(2), PCyPh(2), PMe(3), AsMePh(2), or L(2) = dppe (1,2-bis(diphenylphosphino)ethane), dppf (1,1'-bis(diphenylphosphino)ferrocene). The values determined show that the substitution enthalpy has a strong dependence on the electronic and steric properties of the ligand. The study of the consecutive substitution reactions cis-[PdRf(2)(THF)(2)] + L -->cis-[PdRf(2)L(THF)] + THF, and cis-[PdRf(2)L(THF)] + L -->cis-[PdRf(2)L(2)] + THF has been carried our for L = PPh(3) and L = PCyPh(2). The first substitution is clearly more favorable for the bulkier leaving ligand, but the second gives practically the same DeltaH value for both cases, indicating that the differences in steric hindrance happen to compensate the electronic differences for both ligands. The X-ray structures of cis-[PdRf(2)(PMePh(2))(2)], cis-[PdRf(2)(dppe)] and cis-[PdRf(2)(dppf)] are reported.

  10. How to Read a U.S. Supreme Court Opinion

    ERIC Educational Resources Information Center

    Middleton, Tiffany

    2013-01-01

    Reading U.S. Supreme Court opinions can be intimidating. Yet, in the digital age, it has never been easier to access them. The average opinion is about 4,750 words, and is one of approximately 75 issued by the Court each year. It might be reassuring to know that opinions contain similar parts and tend to follow a similar format. There are also…

  11. Professional practices and opinions about services available to bilingual children with developmental disabilities: An international study.

    PubMed

    Marinova-Todd, Stefka H; Colozzo, Paola; Mirenda, Pat; Stahl, Hillary; Kay-Raining Bird, Elizabeth; Parkington, Karisa; Cain, Kate; Scherba de Valenzuela, Julia; Segers, Eliane; MacLeod, Andrea A N; Genesee, Fred

    This study aimed to gather information from school- and clinic-based professionals about their practices and opinions pertaining to the provision of bilingual supports to students with developmental disabilities. Using an online survey, data were collected in six socio-culturally and linguistically diverse locations across four countries: the United States, Canada, the United Kingdom, and the Netherlands. In total, 361 surveys were included in the analysis from respondents who were primarily teachers and speech-language pathologists working in schools, daycares/preschools, or community-based clinics. The overall picture that emerged from the data reflected a disconnection between practice and opinion. In general, respondents believed that children with both mild and severe disabilities are capable of learning a second language, although their opinions were more neutral for the latter group. However, children with both mild and severe disabilities who spoke only a minority language at home had less access to services for second language learners than did their typically developing peers, although respondents agreed that such services should be more available. Regardless of clinical group, children who lived in homes where a minority language was spoken were often exposed to, assessed in, and treated in the majority language only; again, respondents generally disagreed with these practices. Finally, second language classes were less available to children in the two disability groups compared to typically developing bilingual children, with general agreement that the opportunity to acquire a second language should be more available, especially to those with mild disabilities. Although the results indicate that there is a considerable gap between current practices and professional opinions, professionals appear to be more supportive of bilingual educational opportunities for these populations than was suggested by previous research.

  12. Correlation between information diffusion and opinion evolution on social media

    NASA Astrophysics Data System (ADS)

    Xiong, Fei; Liu, Yun; Zhang, Zhenjiang

    2014-12-01

    Information diffusion and opinion evolution are often treated as two independent processes. Opinion models assume the topic reaches each agent and agents initially have their own ideas. In fact, the processes of information diffusion and opinion evolution often intertwine with each other. Whether the influence between these two processes plays a role in the system state is unclear. In this paper, we collected more than one million real data from a well-known social platform, and analysed large-scale user diffusion behaviour and opinion formation. We found that user inter-event time follows a two-scaling power-law distribution with two different power exponents. Public opinion stabilizes quickly and evolves toward the direction of convergence, but the consensus state is prevented by a few opponents. We propose a three-state opinion model accompanied by information diffusion. Agents form and exchange their opinions during information diffusion. Conversely, agents' opinions also influence their diffusion actions. Simulations show that the model with a correlation of the two processes produces similar statistical characteristics as empirical results. A fast epidemic process drives individual opinions to converge more obviously. Unlike previous epidemic models, the number of infected agents does not always increase with the update rate, but has a peak with an intermediate value of the rate.

  13. Harry and Louise and health care reform: romancing public opinion.

    PubMed

    Goldsteen, R L; Goldsteen, K; Swan, J H; Clemeña, W

    2001-12-01

    The question whether the "Harry and Louise" campaign ads, sponsored by the Health Insurance Association of America (HIAA) during the 1993-1994 health care reform debate, influenced public opinion has particular relevance today since interest groups are increasingly choosing commercial-style mass media campaigns to sway public opinion about health policy issues. Our study revisits the issue of the Harry and Louise campaign's influence on public opinion, comparing the ad campaign's messages to changes in opinion about health care reform over a twenty-six-month period in Oklahoma. Looking at the overall trends just prior to the introduction of the Harry and Louise campaign, public opinion was going in the "wrong" direction, from the HIAA perspective. Moreover, public opinion continued in the wrong direction until the mid-point of the campaign. However, in either the turning point of the campaign in terms of message content and tone or in the lag period following it, public opinion reversed on each health reform issue and returned to pre-campaign levels. It appears from these findings that the campaign captured public opinion when support for issues that were unfavorable to HIAA members was increasing and turned public opinion back to pre-campaign levels. The campaign may result in many more such marriages of political interest groups and commercial advertisers for the purpose of demobilizing public support for health policy initiatives that are unfavorable to special interests.

  14. Sznajd Opinion Dynamics with Global and Local Neighborhood

    NASA Astrophysics Data System (ADS)

    Schulze, Christian

    In this modification of the Sznajd consensus model on the square lattice, two people of arbitrary distance who agree in their opinions convince their nearest neighbors of this opinion. Similarly to the mean field theory of Slanina and Lavicka, the times needed to reach consensus are distributed exponentially and are quite small. The width of the phase transition vanishes reciprocally to the linear lattice dimension. Advertising has effects independent of the system size. For more than two opinions, three opinions reach a consensus in roughly half of the samples, and four only rarely and only for small lattices. Up to 109 agents were simulated.

  15. Distant cis Regulatory Elements in Human Skeletal Muscle Differentiation

    PubMed Central

    McCord, Rachel Patton; Zhou, Vicky W.; Yuh, Tiffany; Bulyk, Martha L.

    2011-01-01

    Identifying gene regulatory elements and their target genes in human cells remains a significant challenge. Despite increasing evidence of physical interactions between distant regulatory elements and gene promoters in mammalian cells, many studies consider only promoter-proximal regulatory regions. We identify putative cis-regulatory modules (CRMs) in human skeletal muscle differentiation by combining myogenic TF binding data before and after differentiation with histone modification data in myoblasts. CRMs that are distant (>20 kb) from muscle gene promoters are common and are more likely than proximal promoter regions to show differentiation-specific changes in myogenic TF binding. We find that two of these distant CRMs, known to activate transcription in differentiating myoblasts, interact physically with gene promoters (PDLIM3 and ACTA1) during differentiation. Our results highlight the importance of considering distal CRMs in investigations of mammalian gene regulation and support the hypothesis that distant CRM-promoter looping contacts are a general mechanism of gene regulation. PMID:21907276

  16. Fungal regulatory evolution: cis and trans in the balance

    PubMed Central

    Thompson, Dawn Anne; Regev, Aviv

    2009-01-01

    Regulatory divergence is likely a major driving force in evolution. Comparative genomics is being increasingly used to infer the evolution of gene regulation. Ascomycota fungi are uniquely suited among eukaryotes for regulatory evolution studies, due to broad phylogenetic scope, many sequenced genomes, and tractability of genomic analysis. Here we review recent advances in the identification of the contribution of cis and trans factors to expression divergence. Whereas current strategies have led to the discovery of surprising signatures and mechanisms, we still understand very little about the adaptive role of regulatory evolution. Empirical studies including experimental evolution, comparative functional genomics and hybrid and engineered strains are showing early promise toward deciphering the contribution of regulatory divergence to adaptation. PMID:19914250

  17. Mechanism of cis-prenyltransferase reaction probed by substrate analogues.

    PubMed

    Lu, Yen-Pin; Liu, Hon-Ge; Teng, Kuo-Hsun; Liang, Po-Huang

    2010-10-01

    Undecaprenyl pyrophosphate synthase (UPPS) is a cis-type prenyltransferases which catalyzes condensation reactions of farnesyl diphosphate (FPP) with eight isopentenyl pyrophosphate (IPP) units to generate C(55) product. In this study, we used two analogues of FPP, 2-fluoro-FPP and [1,1-(2)H(2)]FPP, to probe the reaction mechanism of Escherichia coli UPPS. The reaction rate of 2-fluoro-FPP with IPP under single-turnover condition is similar to that of FPP, consistent with the mechanism without forming a farnesyl carbocation intermediate. Moreover, the deuterium secondary KIE of 0.985±0.022 measured for UPPS reaction using [1,1-(2)H(2)]FPP supports the associative transition state. Unlike the sequential mechanism used by trans-prenyltransferases, our data demonstrate E. coli UPPS utilizes the concerted mechanism.

  18. TFM-Explorer: mining cis-regulatory regions in genomes

    PubMed Central

    Tonon, Laurie; Varré, Jean-Stéphane

    2010-01-01

    DNA-binding transcription factors (TFs) play a central role in transcription regulation, and computational approaches that help in elucidating complex mechanisms governing this basic biological process are of great use. In this perspective, we present the TFM-Explorer web server that is a toolbox to identify putative TF binding sites within a set of upstream regulatory sequences of genes sharing some regulatory mechanisms. TFM-Explorer finds local regions showing overrepresentation of binding sites. Accepted organisms are human, mouse, rat, chicken and drosophila. The server employs a number of features to help users to analyze their data: visualization of selected binding sites on genomic sequences, and selection of cis-regulatory modules. TFM-Explorer is available at http://bioinfo.lifl.fr/TFM. PMID:20522509

  19. Twine: display and analysis of cis-regulatory modules

    PubMed Central

    Pearson, Joseph C.; Crews, Stephen T.

    2013-01-01

    Summary: Many algorithms analyze enhancers for overrepresentation of known and novel motifs, with the goal of identifying binding sites for direct regulators of gene expression. Twine is a Java GUI with multiple graphical representations (‘Views’) of enhancer alignments that displays motifs, as IUPAC consensus sequences or position frequency matrices, in the context of phylogenetic conservation to facilitate cis-regulatory element discovery. Thresholds of phylogenetic conservation and motif stringency can be altered dynamically to facilitate detailed analysis of enhancer architecture. Views can be exported to vector graphics programs to generate high-quality figures for publication. Twine can be extended via Java plugins to manipulate alignments and analyze sequences. Availability: Twine is freely available as a compiled Java .jar package or Java source code at http://labs.bio.unc.edu/crews/twine/. Contact: steve_crews@unc.edu Supplementary information: Supplementary data are available at Bioinformatics online. PMID:23658420

  20. Options for Staging Orbits in Cis-Lunar Space

    NASA Technical Reports Server (NTRS)

    Whitley, Ryan; Martinez, Roland

    2015-01-01

    NASA has been studying options to conduct missions beyond Low Earth Orbit, but within the Earth-Moon system, in preparation for deep space exploration including human missions to Mars. Referred to as the Proving Ground, this arena of exploration activities will enable the development of human spaceflight systems and operations to satisfy future exploration objectives beyond the cis-lunar environment. One option being considered includes the deployment of a habitable element or elements, which could be used as a central location for aggregation of supplies and resources for human missions in cis-lunar space and beyond. Characterizing candidate orbit locations for this asset and the impacts on system design and mission operations is important in the overall assessment of the options being considered. The orbits described in this paper were initially selected by taking advantage of previous studies conducted by NASA and the work of other authors. In this paper orbits are assessed for their relative attractiveness based on various factors. First, a set of constraints related to the capability of the combined Orion and SLS system to deliver humans and cargo to and from the orbit are evaluated. Second, the ability to support potential lunar surface activities is considered. Finally, deployed assets intended to spend multiple years in the Proving Ground would ideally require minimal station keeping costs to reduce the mass budget allocated to this function. Additional mission design drivers include potential for uninterrupted communication with deployed assets, thermal, communications, and other operational implications. The results of the characterization and evaluation of the selected orbits indicate a Near Rectilinear Orbit (NRO) is an attractive candidate as an aggregation point or staging location for operations. In this paper, the NRO is further described in terms which balance a number of key attributes that favor a variety of mission classes to meet multiple

  1. Options for Staging Orbits in Cis-Lunar Space

    NASA Technical Reports Server (NTRS)

    Martinez, Roland; Whitley, Ryan

    2016-01-01

    NASA has been studying options to conduct missions beyond Low Earth Orbit, but within the Earth-Moon system, in preparation for deep space exploration including human missions to Mars. Referred to as the Proving Ground, this arena of exploration activities will enable the development of human spaceflight systems and operations to satisfy future exploration objectives beyond the cis-lunar environment. One option being considered includes the deployment of a habitable element or elements, which could be used as a central location for aggregation of supplies and resources for human missions in cis-lunar space and beyond. Characterizing candidate orbit locations for this asset and the impacts on system design and mission operations is important in the overall assessment of the options being considered. The orbits described in this paper were initially selected by taking advantage of previous studies conducted by NASA and the work of other authors. In this paper orbits are assessed for their relative attractiveness based on various factors. A set of constraints related to the capability of the combined Orion and SLS system to deliver humans and cargo to and from the orbit are evaluated. Deployed assets intended to spend multiple years in the Proving Ground would ideally require minimal station keeping costs to reduce the mass budget allocated to this function. Additional mission design drivers include eclipse frequency, potential for uninterrupted communication with deployed assets, thermal, attitude control, communications, and other operational implications. Also the ability to support potential lunar surface activities and excursion missions beyond Earth-Moon space is considered. The results of the characterization and evaluation of the selected orbits indicate a Near Rectilinear Orbit (NRO) is an attractive candidate as an aggregation point or staging location for operations. In this paper, the NRO is further described in terms which balance a number of key

  2. Uncovering cis Regulatory Codes Using Synthetic Promoter Shuffling

    PubMed Central

    Kinkhabwala, Ali; Guet, Călin C.

    2008-01-01

    Revealing the spectrum of combinatorial regulation of transcription at individual promoters is essential for understanding the complex structure of biological networks. However, the computations represented by the integration of various molecular signals at complex promoters are difficult to decipher in the absence of simple cis regulatory codes. Here we synthetically shuffle the regulatory architecture — operator sequences binding activators and repressors — of a canonical bacterial promoter. The resulting library of complex promoters allows for rapid exploration of promoter encoded logic regulation. Among all possible logic functions, NOR and ANDN promoter encoded logics predominate. A simple transcriptional cis regulatory code determines both logics, establishing a straightforward map between promoter structure and logic phenotype. The regulatory code is determined solely by the type of transcriptional regulation combinations: two repressors generate a NOR: NOT (a OR b) whereas a repressor and an activator generate an ANDN: a AND NOT b. Three-input versions of both logics, having an additional repressor as an input, are also present in the library. The resulting complex promoters cover a wide dynamic range of transcriptional strengths. Synthetic promoter shuffling represents a fast and efficient method for exploring the spectrum of complex regulatory functions that can be encoded by complex promoters. From an engineering point of view, synthetic promoter shuffling enables the experimental testing of the functional properties of complex promoters that cannot necessarily be inferred ab initio from the known properties of the individual genetic components. Synthetic promoter shuffling may provide a useful experimental tool for studying naturally occurring promoter shuffling. PMID:18446205

  3. Teachers' Opinion about the Nature of Giftedness.

    ERIC Educational Resources Information Center

    David, Imre; Balogh, Laszlo

    1997-01-01

    This article discusses the results of a survey that queried 34 Hungarian teachers of gifted children on the definition of gifted children, developing giftedness, behavior problems of gifted children, enrichment activities, and parent participation. The teachers were attending in-service training on giftedness. Findings of the survey indicate that…

  4. A survey of surveys

    SciTech Connect

    Kent, S.M.

    1994-11-01

    A new era for the field of Galactic structure is about to be opened with the advent of wide-area digital sky surveys. In this article, the author reviews the status and prospects for research for 3 new ground-based surveys: the Sloan Digital Sky Survey (SDSS), the Deep Near-Infrared Survey of the Southern Sky (DENIS) and the Two Micron AU Sky Survey (2MASS). These surveys will permit detailed studies of Galactic structure and stellar populations in the Galaxy with unprecedented detail. Extracting the information, however, will be challenging.

  5. The Opinion Editorial: teaching physiology outside the box.

    PubMed

    Poronnik, Philip; Moni, Roger W

    2006-06-01

    Improving the public understanding of science is an important challenge for the future professional scientists who are our current undergraduates. In this paper, we present a conceptual model that explores the role of mass media as community gatekeepers of new scientific findings. This model frames the benefits for undergraduate science students to learn about media genres so that they can learn to communicate science more effectively to nonprofessional audiences. Informed by this Media Role model, we then detail a novel writing task for undergraduate physiology students, the Opinion Editorial (Op-Ed), and an accompanying Peer Review. The Op-Ed genre was directly taught to the students by a professional journalist. As an assessment task, students presented a recent, highly technical paper as an Op-Ed. This was assessed by both faculty members and peers using a detailed assessment rubric. Most students were able to replicate the features of Op-Eds and attained high grades on their writing tasks. Survey data from final-year physiology students (n = 230) were collected before and after the implementation of the Op-Ed/Peer Review. These indicated that most students were aware of the importance of scientists to effectively communicate their knowledge to nonprofessional audiences, that the Op-Ed writing task was challenging, and that they believed that their ability to write to nonprofessional audiences was improved after explicit teaching and feedback.

  6. Public opinion on renal transplantation in Brunei Darussalam.

    PubMed

    Teo, T T; Hossain, M M; Zinna, S; Liew, Y P; Tan, J

    2011-12-01

    Brunei Darussalam is a small Muslim country with a high prevalence and incidence of kidney disease. At present, there is no local transplant program for patients on the renal replacement therapy program. In order to assess feasibility of a local transplant program, we decided to conduct a survey to assess public opinion on renal transplantation. The majority of the 300 respondents (78.7%) were willing to donate their kidneys if needed. Even after learning of the small theoretical risks of kidney failure, 72.33% of all respondents were still willing to proceed with transplantation. Respondents who had relatives on dialysis and who had a higher education level were more willing to donate their kidneys. There was no significant difference between Muslims and non-Muslims. Most respondents (59.7%) preferred to have transplantation done locally. This study shows that most Bruneians are receptive of the idea of living related kidney donations, which augurs well for the sustainability of a new program. More work is needed to overcome other barriers like the availability of surgical expertise and facilities and cost-benefit considerations.

  7. Organizational Readiness for Change and Opinions toward Treatment Innovations

    PubMed Central

    Fuller, Bret E.; Rieckmann, Traci; Nunes, Edward V.; Miller, Michael; Arfken, Cynthia; Edmundson, Eldon; McCarty, Dennis

    2007-01-01

    Program administrators and staff in treatment programs participating in the National Drug Abuse Treatment Clinical Trials Network (CTN) completed surveys to characterize participating programs and practitioners. A two-level random effects regression model assessed the influence of Organizational Readiness for Change (ORC) and organizational attributes on opinions toward the use of four evidence-based practices (manualized treatments, medication, integrated mental health services, and motivational incentives) and practices with less empirical support (confrontation and noncompliance discharge). The ORC Scales suggested greater support for evidence-based practices in programs where staff perceived more program need for improvement, better Internet access, higher levels of peer influence, more opportunities for professional growth, a stronger sense of organizational mission and more organizational stress. Support for confrontation and noncompliance discharge, in contrast, was strong when staff saw less opportunity for professional growth, weaker peer influence, less Internet access, and perceived less organizational stress. The analysis provides evidence of the ORC’s utility in assessing agency strengths and needs during the implementation of evidence-based practices. PMID:17434708

  8. The Development of the STEM Career Interest Survey (STEM-CIS)

    ERIC Educational Resources Information Center

    Kier, Meredith W.; Blanchard, Margaret R.; Osborne, Jason W.; Albert, Jennifer L.

    2014-01-01

    Internationally, efforts to increase student interest in science, technology, engineering, and mathematics (STEM) careers have been on the rise. It is often the goal of such efforts that increased interest in STEM careers should stimulate economic growth and enhance innovation. Scientific and educational organizations recommend that efforts to…

  9. Adaptation of the Science, Technology, Engineering, and Mathematics Career Interest Survey (STEM-CIS) into Turkish

    ERIC Educational Resources Information Center

    Koyunlu Unlu, Zeynep; Dokme, Ilbilge; Unlu, Veli

    2016-01-01

    Problem Statement: Science, technology, engineering, and mathematics (STEM) education has recently become a remarkable research topic, especially in developed countries as a result of the skilled workforce required in the fields of the STEM. Considering that professional tendencies are revealed at early ages, determining students' interest in STEM…

  10. Doctors’ opinions of information provided by Libyan pharmaceutical company representatives

    PubMed Central

    Alssageer, Mustafa A.; Kowalski, Stefan R.

    2012-01-01

    Objective To examine the opinions of Libyan doctors regarding the quality of drug information provided by pharmaceutical company representatives (PCRs) during detailing visits. Method An anonymous survey was conducted among 1,000 doctors from selected institutes in Tripoli, Benghazi and Sebha. Doctors were asked questions regarding the quality of information provided during drug-detailing visits. Results A questionnaire return rate of 61% (608 returned questionnaires out of 1,000) was achieved. The majority (n=463, 76%) of surveyed participants graded the quality of information provided as average. Approximately, 40% of respondents indicated that contraindications, precautions, interactions and adverse effects of products promoted by PCRs were never or rarely mentioned during promotional visits, and 65% of respondents indicated that an alternative drug to the promoted product was never or rarely mentioned by the representatives. More than 50% of respondents (n=310, 51%) reported that PCRs were not always able to answer all questions about their products. Only seven respondents (1%) believed that PCRs never exaggerated the uniqueness, efficacy or safety of their product. The majority of respondents (n=342, 56%) indicated that verbal information was not always consistent with written information provided. Seven per cent of respondents (n=43) admitted that they did not know whether or not the verbal information provided by PCRs was consistent with written information. Conclusion Doctors believe that the provision of drug information by PCRs in Libya is incomplete and often exaggerated. Pharmaceutical companies should ensure that their representatives are trained to a standard to provide reliable information regarding the products they promote. PMID:23205141

  11. Organocatalytic, Diastereo- and Enantioselective Synthesis of Nonsymmetric cis-Stilbene Diamines: A Platform for the Preparation of Single-Enantiomer cis-Imidazolines for Protein–Protein Inhibition

    PubMed Central

    2015-01-01

    The finding by scientists at Hoffmann-La Roche that cis-imidazolines could disrupt the protein–protein interaction between p53 and MDM2, thereby inducing apoptosis in cancer cells, raised considerable interest in this scaffold over the past decade. Initial routes to these small molecules (i.e., Nutlin-3) provided only the racemic form, with enantiomers being enriched by chromatographic separation using high-pressure liquid chromatography (HPLC) and a chiral stationary phase. Reported here is the first application of an enantioselective aza-Henry approach to nonsymmetric cis-stilbene diamines and cis-imidazolines. Two novel mono(amidine) organocatalysts (MAM) were discovered to provide high levels of enantioselection (>95% ee) across a broad range of substrate combinations. Furthermore, the versatility of the aza-Henry strategy for preparing nonsymmetric cis-imidazolines is illustrated by a comparison of the roles of aryl nitromethane and aryl aldimine in the key step, which revealed unique substrate electronic effects providing direction for aza-Henry substrate–catalyst matching. This method was used to prepare highly substituted cis-4,5-diaryl imidazolines that project unique aromatic rings, and these were evaluated for MDM2-p53 inhibition in a fluorescence polarization assay. The diversification of access to cis-stilbene diamine-derived imidazolines provided by this platform should streamline their further development as chemical tools for disrupting protein–protein interactions. PMID:25017623

  12. Clustering and asymptotic behavior in opinion formation

    NASA Astrophysics Data System (ADS)

    Jabin, Pierre-Emmanuel; Motsch, Sebastien

    2014-12-01

    We investigate the long time behavior of models of opinion formation. We consider the case of compactly supported interactions between agents which are also non-symmetric, including for instance the so-called Krause model. Because of the finite range of interaction, convergence to a unique consensus is not expected in general. We are nevertheless able to prove the convergence to a final equilibrium state composed of possibly several local consensus. This result had so far only been conjectured through numerical evidence. Because of the non-symmetry in the model, the analysis is delicate and is performed in two steps: First using entropy estimates to prove the formation of stable clusters and then studying the evolution in each cluster. We study both discrete and continuous in time models and give rates of convergence when those are available.

  13. Advanced nuclear reactor public opinion project

    SciTech Connect

    Benson, B.

    1991-07-25

    This Interim Report summarizes the findings of our first twenty in-depth interviews in the Advanced Nuclear Reactor Public Opinion Project. We interviewed 6 industry trade association officials, 3 industry attorneys, 6 environmentalists/nuclear critics, 3 state officials, and 3 independent analysts. In addition, we have had numerous shorter discussions with various individuals concerned about nuclear power. The report is organized into the four categories proposed at our April, 1991, Advisory Group meeting: safety, cost-benefit analysis, science education, and communications. Within each category, some change of focus from that of the Advisory Group has been required, to reflect the findings of our interviews. This report limits itself to describing our findings. An accompanying memo draws some tentative conclusions.

  14. Geothermal development attitudes surveyed

    SciTech Connect

    Not Available

    1986-01-01

    The State of Hawaii has conducted several surveys on public opinion towards the development of geothermal energy. The latest poll was designed to: measure public opinion in the County of Hawaii relevant to geothermal development for electrical power supplied to Island of Hawaii residents only; measure public opinion in the County of Hawaii relevant to geothermal development of electricity to be exported for use on Oahu; and identify barriers to, and opportunities for energy conservation programs, including geothermal development. In general, the residents of the County of Hawaii favor some form of geothermal development. Issues on geothermal development of concern to the public were similar to those mentioned in the 1982 study. Basically, the issues amount to a trade-off between the economic advantages and the environmental problems of geothermal development. The strong points in favor of development include a perceived need for more energy, a strong preference for alternate energy forms over petroleum, perceived benefits for the local economy and the employment rates, and the possibility that development may reduce or contain utility bills. On the other hand, it appears that geothermal development will cause health problems for those who live near the wells, be hazardous to flora and fauna in the Puna area, and create noise and odor above tolerable levels. These are oversimplified statements of the reasons behind both support and opposition for geothermal development.

  15. What Do We Measure? Methodological versus Institutional Validity in Student Surveys

    ERIC Educational Resources Information Center

    Johnson, Jeffrey Alan

    2011-01-01

    This paper examines the tension in the process of designing student surveys between the methodological requirements of good survey design and the institutional needs for survey data. Building on the commonly used argumentative approach to construct validity, I build an interpretive argument for student opinion surveys that allows assessment of the…

  16. Planning "and" Sprinting: Use of a Hybrid Project Management Methodology within a CIS Capstone Course

    ERIC Educational Resources Information Center

    Baird, Aaron; Riggins, Frederick J.

    2012-01-01

    An increasing number of information systems projects in industry are managed using hybrid project management methodologies, but this shift in project management methods is not fully represented in our CIS curriculums. CIS capstone courses often include an applied project that is managed with traditional project management methods (plan first,…

  17. The Influence of 13-cis Retinoic Acid on Human Meibomian Gland Epithelial Cells

    PubMed Central

    Ding, Juan; Kam, Wendy R.; Dieckow, Julia; Sullivan, David A.

    2013-01-01

    Purpose. Meibomian gland dysfunction (MGD) is a primary cause of dry eye disease. One of the risk factors for MGD is exposure to 13-cis retinoic acid (13-cis RA), a metabolite of vitamin A. However, the mechanism is not well understood. We hypothesize that 13-cis RA inhibits cell proliferation, promotes cell death, alters gene and protein expressions, and attenuates cell survival pathways in human meibomian gland epithelial cells. Methods. To test our hypotheses, immortalized human meibomian gland epithelial cells were cultured with or without 13-cis RA for varying doses and time. Cell proliferation, cell death, gene expression, and proteins involved in proliferation/survival and inflammation were evaluated. Results. We found that 13-cis RA inhibited cell proliferation, induced cell death, and significantly altered the expression of 6726 genes, including those involved in cell proliferation, cell death, differentiation, keratinization, and inflammation, in human meibomian gland epithelial cells. Further, 13-cis RA also reduced the phosphorylation of Akt and increased the generation of interleukin-1β and matrix metallopeptidase 9. Conclusions. Exposure to 13-cis RA inhibits cell proliferation, increases cell death, alters gene expression, changes signaling pathways, and promotes inflammatory mediator and protease expression in meibomian gland epithelial cells. These effects may be responsible, at least in part, for the 13-cis RA–related induction of MGD. PMID:23722388

  18. A CIS (Clinical Information System) Quality Evaluation Tool for Nursing Care Services

    ERIC Educational Resources Information Center

    Lee, Seon Ah

    2010-01-01

    The purpose of this study was to develop a tool to evaluate the quality of a clinical information system (CIS) conceived by nurses and conduct a pilot test with the developed tool as an initial assessment. CIS quality is required for successful implementation in information technology (IT) environments. The study started with the realization that…

  19. Cloning, Expression, and Characterization of cis-Polyprenyl Diphosphate Synthase from the Thermoacidophilic Archaeon Sulfolobus acidocaldarius

    PubMed Central

    Hemmi, Hisashi; Yamashita, Satoshi; Shimoyama, Takefumi; Nakayama, Toru; Nishino, Tokuzo

    2001-01-01

    cis-polyprenyl diphosphate synthases are involved in the biosynthesis of the glycosyl carrier lipid in most organisms. However, only little is known about this enzyme of archaea. In this report, we isolated the gene of cis-polyprenyl diphosphate synthase from a thermoacidophilic archaeon, Sulfolobus acidocaldarius, and characterized the recombinant enzyme. PMID:11114943

  20. Columbia River Coordinated Information System (CIS), 1992-1993 Annual Report.

    SciTech Connect

    Rowe, Mike; Roger, Phillip B.; O'Connor, Dick

    1993-11-01

    The purposes of this report are to: (1) describe the project to date; (2) to document the work and accomplishments of the (CIS) project for Fiscal Year 1993; and (3) to provide a glimpse of future project direction. The concept of a Coordinated Information System (CIS) as an approach to meeting the growing needs for regionally standardized anadromous fish information.

  1. Surveying Future Surveys

    NASA Astrophysics Data System (ADS)

    Carlstrom, John E.

    2016-06-01

    The now standard model of cosmology has been tested and refined by the analysis of increasingly sensitive, large astronomical surveys, especially with statistically significant millimeter-wave surveys of the cosmic microwave background and optical surveys of the distribution of galaxies. This talk will offer a glimpse of the future, which promises an acceleration of this trend with cosmological information coming from new surveys across the electromagnetic spectrum as well as particles and even gravitational waves.

  2. 22 CFR 126.9 - Advisory opinions and related authorizations.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Advisory opinions and related authorizations. 126.9 Section 126.9 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL TRAFFIC IN ARMS REGULATIONS GENERAL POLICIES AND PROVISIONS § 126.9 Advisory opinions and related authorizations. (a) Advisory...

  3. 29 CFR 18.701 - Opinion testimony by lay witnesses.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 1 2010-07-01 2010-07-01 true Opinion testimony by lay witnesses. 18.701 Section 18.701 Labor Office of the Secretary of Labor RULES OF PRACTICE AND PROCEDURE FOR ADMINISTRATIVE HEARINGS... Opinion testimony by lay witnesses. If the witness is not testifying as an expert, the witness'...

  4. 42 CFR 411.386 - CMS's advisory opinions as exclusive.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 2 2013-10-01 2013-10-01 false CMS's advisory opinions as exclusive. 411.386... Relationships Between Physicians and Entities Furnishing Designated Health Services § 411.386 CMS's advisory... described in § 411.370. CMS has not and does not issue a binding advisory opinion on the subject matter...

  5. 42 CFR 411.386 - CMS's advisory opinions as exclusive.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 2 2014-10-01 2014-10-01 false CMS's advisory opinions as exclusive. 411.386... Relationships Between Physicians and Entities Furnishing Designated Health Services § 411.386 CMS's advisory... described in § 411.370. CMS has not and does not issue a binding advisory opinion on the subject matter...

  6. 42 CFR 411.386 - CMS's advisory opinions as exclusive.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 2 2010-10-01 2010-10-01 false CMS's advisory opinions as exclusive. 411.386... Relationships Between Physicians and Entities Furnishing Designated Health Services § 411.386 CMS's advisory... described in § 411.370. CMS has not and does not issue a binding advisory opinion on the subject matter...

  7. 42 CFR 411.386 - CMS's advisory opinions as exclusive.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 2 2012-10-01 2012-10-01 false CMS's advisory opinions as exclusive. 411.386... Relationships Between Physicians and Entities Furnishing Designated Health Services § 411.386 CMS's advisory... described in § 411.370. CMS has not and does not issue a binding advisory opinion on the subject matter...

  8. 42 CFR 411.386 - CMS's advisory opinions as exclusive.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 2 2011-10-01 2011-10-01 false CMS's advisory opinions as exclusive. 411.386... Relationships Between Physicians and Entities Furnishing Designated Health Services § 411.386 CMS's advisory... described in § 411.370. CMS has not and does not issue a binding advisory opinion on the subject matter...

  9. Nanotechnology Awareness, Opinions and Risk Perceptions among Middle School Students

    ERIC Educational Resources Information Center

    Sahin, Nurettin; Ekli, Emel

    2013-01-01

    The present study investigates awareness, factual knowledge, opinions, and risk perceptions of students from Turkish middle schools with regard to nanotechnology in a very general sense. The study was carried out among 1,396 middle school 6th, 7th, and 8th grade students. The students' perceptions of and opinions about nanotechnology were elicited…

  10. Opinion Leadership Development: Context and Audience Characteristics Count

    ERIC Educational Resources Information Center

    Lamm, Kevan W.; Lamm, Alexa J.; Carter, Hannah S.

    2014-01-01

    Opinion leaders have been shown to have a significant amount of influence on their peers, yet there is little research examining how individual traits of opinion leaders are related. Generally the assumption is that these individuals share characteristics consistent with the literature; specifically that leaders tend to be optimistically oriented…

  11. 28 CFR 0.66 - Delegation respecting title opinions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 28 Judicial Administration 1 2011-07-01 2011-07-01 false Delegation respecting title opinions. 0.66 Section 0.66 Judicial Administration DEPARTMENT OF JUSTICE ORGANIZATION OF THE DEPARTMENT OF JUSTICE Environment and Natural Resources Division § 0.66 Delegation respecting title opinions. (a) The Assistant Attorney General in charge of...

  12. 29 CFR 1601.93 - Opinions-title VII.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 4 2012-07-01 2012-07-01 false Opinions-title VII. 1601.93 Section 1601.93 Labor Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION PROCEDURAL REGULATIONS Title VII Interpretations and Opinions by the Commission § 1601.93 Opinions—title VII. Only the following may be relied upon as a “written...

  13. 28 CFR 0.66 - Delegation respecting title opinions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 28 Judicial Administration 1 2014-07-01 2014-07-01 false Delegation respecting title opinions. 0.66 Section 0.66 Judicial Administration DEPARTMENT OF JUSTICE ORGANIZATION OF THE DEPARTMENT OF JUSTICE Environment and Natural Resources Division § 0.66 Delegation respecting title opinions. (a) The Assistant Attorney General in charge of...

  14. 28 CFR 0.66 - Delegation respecting title opinions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 28 Judicial Administration 1 2012-07-01 2012-07-01 false Delegation respecting title opinions. 0.66 Section 0.66 Judicial Administration DEPARTMENT OF JUSTICE ORGANIZATION OF THE DEPARTMENT OF JUSTICE Environment and Natural Resources Division § 0.66 Delegation respecting title opinions. (a) The Assistant Attorney General in charge of...

  15. 29 CFR 1601.93 - Opinions-title VII.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 4 2010-07-01 2010-07-01 false Opinions-title VII. 1601.93 Section 1601.93 Labor Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION PROCEDURAL REGULATIONS Title VII Interpretations and Opinions by the Commission § 1601.93 Opinions—title VII. Only the following may be relied upon as a “written...

  16. The Opinions of Economics Majors before and after Learning Economics

    ERIC Educational Resources Information Center

    Hammock, Michael R.; Routon, P. Wesley; Walker, Jay K.

    2016-01-01

    Using longitudinal data on undergraduates from 463 American colleges and universities from 1994-99, the authors examine how majoring in economics affects student opinions on 13 social, political, and economic issues. Economics majors were found to begin and end their college tenure with differing opinions on several issues when compared to other…

  17. 38 CFR 3.328 - lndependent medical opinions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2011-07-01 2011-07-01 false lndependent medical... Connection § 3.328 lndependent medical opinions. (a) General. When warranted by the medical complexity or controversy involved in a pending claim, an advisory medical opinion may be obtained from one or more...

  18. 28 CFR 0.66 - Delegation respecting title opinions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... JUSTICE Environment and Natural Resources Division § 0.66 Delegation respecting title opinions. (a) The Assistant Attorney General in charge of the Environment and Natural Resources Division or such members of... 28 Judicial Administration 1 2013-07-01 2013-07-01 false Delegation respecting title opinions....

  19. Opinion Leadership and Communication Linkages Among Agricultural Educators. Final Report.

    ERIC Educational Resources Information Center

    Blanton, Lloyd H.; And Others

    This study of opinion leadership among vocational agriculture teachers in South Carolina solicited nominations of teachers as sources of information and advice from participating teachers at two different points in time, spring 1968 and spring 1970. This time-lapsed design allowed an estimate of opinion leadership stability since the sample of…

  20. Students' Opinions on Facebook Supported Blended Learning Environment

    ERIC Educational Resources Information Center

    Erdem, Mukaddes; Kibar, Pinar Nuhoglu

    2014-01-01

    The first purpose of this study was to determine students' opinions on blended learning and its implementation. The other purpose was to explore the students' opinions on Facebook integration into blended learning environment. The participants of this study were 40 undergraduate students in their fourth semester of the program.…

  1. Principals' Opinions of Organisational Justice in Elementary Schools in Turkey

    ERIC Educational Resources Information Center

    Aydin, Inayet; Karaman-Kepenekci, Yasemin

    2008-01-01

    Purpose--This study aims to present the opinions of public elementary school principals in Turkey about the current organisational justice practices among teachers from the distributive, procedural, interactional, and rectificatory dimensions. Design/methodology/approach--The opinions of 11 public elementary school principals in Ankara about…

  2. Opinions of the Geography Teacher Candidates toward Mind Maps

    ERIC Educational Resources Information Center

    Seyihoglu, Aysegul

    2013-01-01

    The purpose of this study is to reveal the opinions of the teacher candidates about mind mapping technique used in Geography education of undergraduate program. In this study, the qualitative research techniques were used. The study group consists of 55 teacher candidates. The teacher candidates have been asked for their opinions about the process…

  3. 14 CFR 406.157 - Expert or opinion witnesses.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 4 2014-01-01 2014-01-01 false Expert or opinion witnesses. 406.157 Section 406.157 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION... Practice in FAA Space Transportation Adjudications § 406.157 Expert or opinion witnesses. An employee...

  4. 14 CFR 406.157 - Expert or opinion witnesses.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 4 2013-01-01 2013-01-01 false Expert or opinion witnesses. 406.157 Section 406.157 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION... Practice in FAA Space Transportation Adjudications § 406.157 Expert or opinion witnesses. An employee...

  5. 14 CFR 406.157 - Expert or opinion witnesses.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 4 2012-01-01 2012-01-01 false Expert or opinion witnesses. 406.157 Section 406.157 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION... Practice in FAA Space Transportation Adjudications § 406.157 Expert or opinion witnesses. An employee...

  6. 14 CFR 406.157 - Expert or opinion witnesses.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Expert or opinion witnesses. 406.157 Section 406.157 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION... Practice in FAA Space Transportation Adjudications § 406.157 Expert or opinion witnesses. An employee...

  7. 14 CFR 406.157 - Expert or opinion witnesses.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 4 2011-01-01 2011-01-01 false Expert or opinion witnesses. 406.157 Section 406.157 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION... Practice in FAA Space Transportation Adjudications § 406.157 Expert or opinion witnesses. An employee...

  8. Attitudes and Opinions of Classroom Teacher Candidates Regarding Multiculturalism

    ERIC Educational Resources Information Center

    Akar, Cuneyt; Ulu, Mustafa

    2016-01-01

    The purpose of this study is twofold. The first objective is to develop a valid and reliable measurement tool for measuring the attitudes and opinions of classroom teachers regarding multiculturalism. The second one is to study the classroom teachers' attitudes and opinions towards multiculturalism in terms of gender, socio-economic and devoutness…

  9. Analysis of Primary School Teachers' Opinions on Family Diversity

    ERIC Educational Resources Information Center

    Bosch, Alvaro Capano; Massonnier, Natalie; González Tornaría, Maria del L.

    2016-01-01

    This article aims to do an analysis based on the opinion of primary school teachers on family models that are different from the traditional nuclear family. We worked with 60 teachers from Montevideo and the metropolitan area. They answered the Questionnaire: Teachers' Opinion on Family Diversity (CIDF for its Spanish acronym) (Morgado,…

  10. Opinion Mining from Web Documents: Extraction and Structurization

    NASA Astrophysics Data System (ADS)

    Kobayashi, Nozomi; Inui, Kentaro; Matsumoto, Yuji

    The task of opinion extraction and structurization is the key component of opinion mining, which allow Web users to retrieve and summarize people's opinions scattered over the Internet. Our aim is to develop a method for extracting opinions that represent evaluation of concumer products in a structured form. To achieve the goal, we need to consider some issues that are relevant to the extraction task: How the task of opinion extraction and structurization should be designed, and how to extract the opinions which we defined. We define an opinion unit consisting of a quadruple, that is, the opinion holder, the subject being evaluated, the part or the attribute in which it is evaluated, and the evaluation that expresses positive or negative assessment. In this task, we focus on two subtasks (a) extracting subject/aspect-evaluation relations, and (b) extracting subject/aspect-aspect relations, we approach each extraction task using a machine learning-based method. In this paper, we discuss how customer reviews in web documents can be best structured. We also report on the results of our experiments and discuss future directions.

  11. The cis-bis(decanoate)tin phthalocyanine/DPPC film at the air/water interface.

    PubMed

    Ramos, Salvador; Garza, Cristina; Beltran, Hiram I; Campos-Terán, José; Arenas-Alatorre, Jesús; Castillo, Rolando

    2012-03-01

    Films made of cis-bis-decanoate-tin(IV) phthalocyanine (PcSn10) and racemic dipalmitoylphosphatidylcholine (DPPC) are studied with compression isotherms and Brewster angle microscopy (BAM) at the air/water interface. Films enriched in PcSn10 present phase separation elliptical-shaped domains. These domains present optical anisotropy and molecular order. They are enriched in PcSn10, and the film outside these domains is enriched in DPPC, as shown in by high-angle annular dark-field transmission electron microscopy on Langmuir-Blodgett (LB) transferred films. Film collapse area and atomic force microscopy images of LB transferred films on mica indicate that the films are actually multilayers. A computational survey was performed to determine how the PcSn10 molecules prefer to self-assemble, in films basically made of PcSn10. The relative energetic stability for several dimeric assemblies was obtained, and a crystal model of the film was developed through packing and repeating the PcSn10 molecules, along the crystallographic directions of the unit cell. Our results contribute to understanding the strong interaction between PcSn10 and DPPC at the air/water interface, where even small quantities of DPPC (~1-2%) can modify the film in an important way.

  12. Cis-9, trans-11 and trans-10, cis-12 CLA mixture does not change body composition, induces insulin resistance and increases serum HDL cholesterol level in rats.

    PubMed

    de Almeida, Mariana Macedo; de Souza, Yamara Oliveira; Dutra Luquetti, Sheila Cristina Potente; Sabarense, Céphora Maria; do Amaral Corrêa, José Otávio; da Conceição, Ellen Paula Santos; Lisboa, Patrícia Cristina; de Moura, Egberto Gaspar; Andrade Soares, Sara Malaguti; Moura Gualberto, Ana Cristina; Gameiro, Jacy; da Gama, Marco Antônio Sundfeld; Ferraz Lopes, Fernando César; González Garcia, Raúl Marcel

    2015-01-01

    Synthetic supplements of conjugated linoleic acid (CLA) containing 50:50 mixture of cis-9, trans-11 and trans-10, cis-12 CLA isomers have been commercialized in some places for reducing body fat. However the safety of this CLA mixture is controversial and in some countries the CLA usage as food supplement is not authorized. Changes in insulinemic control and serum lipids profile are potential negative effects related to consumption of CLA mixture. The present study aimed to evaluate the effects of a diet containing mixture of cis-9, trans-11 and trans-10, cis-12 CLA on prevention of obesity risk as well as on potential side effects such as insulin resistance and dyslipidemia in Wistar rats. Thirty male Wistar rats were randomly assigned to the following dietary treatments (n=10/group), for 60 days: Normolipidic Control (NC), diet containing 4.0% soybean oil (SO); High Fat-Control (HF-C), diet containing 24.0% SO; High Fat-synthetic CLA (HF-CLA), diet containing 1.5% of an isomeric CLA mixture (Luta-CLA 60) and 22.5% SO. Luta-CLA 60 (BASF) contained nearly 60% of CLA (cis-9, trans-11 and trans-10, cis-12 CLA at 50:50 ratio). The HF-CLA diet contained 0.3% of each CLA isomer. HF-CLA diet had no effect on dietary intake and body composition. HF-CLA-fed rats had lower levels of PPARγ protein in retroperitoneal adipose tissue, hyperinsulinemia compared to HF-C-fed rats, hyperglycemia compared to NC-fed rats while no differences in glycemia were observed between NC and HF-C groups, increased HOMA index and higher levels of serum HDL cholesterol. Thus, feeding rats with a high fat diet containing equal parts of cis-9, trans-11 and trans-10, cis-12 CLA isomers had no effect on body composition and induced insulin resistance. Despite HF-CLA-fed rats had increased serum HDL cholesterol levels, caution should be taken before synthetic supplements containing cis-9, trans-11 and trans-10, cis-12 CLA are recommended as a nutritional strategy for weight management.

  13. On the empirical relevance of the transient in opinion models

    NASA Astrophysics Data System (ADS)

    Banisch, Sven; Araújo, Tanya

    2010-07-01

    While the number and variety of models to explain opinion exchange dynamics is huge, attempts to justify the model results using empirical data are relatively rare. As linking to real data is essential for establishing model credibility, this Letter develops an empirical confirmation experiment by which an opinion model is related to real election data. The model is based on a representation of opinions as a vector of k bits. Individuals interact according to the principle that similarity leads to interaction and interaction leads to still more similarity. In the comparison to real data we concentrate on the transient opinion profiles that form during the dynamic process. An artificial election procedure is introduced which allows to relate transient opinion configurations to the electoral performance of candidates for which data are available. The election procedure based on the well-established principle of proximity voting is repeatedly performed during the transient period and remarkable statistical agreement with the empirical data is observed.

  14. Boltzmann-type control of opinion consensus through leaders

    PubMed Central

    Albi, G.; Pareschi, L.; Zanella, M.

    2014-01-01

    The study of formations and dynamics of opinions leading to the so-called opinion consensus is one of the most important areas in mathematical modelling of social sciences. Following the Boltzmann-type control approach recently introduced by the first two authors, we consider a group of opinion leaders who modify their strategy accordingly to an objective functional with the aim of achieving opinion consensus. The main feature of the Boltzmann-type control is that, owing to an instantaneous binary control formulation, it permits the minimization of the cost functional to be embedded into the microscopic leaders’ interactions of the corresponding Boltzmann equation. The related Fokker–Planck asymptotic limits are also derived, which allow one to give explicit expressions of stationary solutions. The results demonstrate the validity of the Boltzmann-type control approach and the capability of the leaders’ control to strategically lead the followers’ opinion. PMID:25288820

  15. Boltzmann-type control of opinion consensus through leaders.

    PubMed

    Albi, G; Pareschi, L; Zanella, M

    2014-11-13

    The study of formations and dynamics of opinions leading to the so-called opinion consensus is one of the most important areas in mathematical modelling of social sciences. Following the Boltzmann-type control approach recently introduced by the first two authors, we consider a group of opinion leaders who modify their strategy accordingly to an objective functional with the aim of achieving opinion consensus. The main feature of the Boltzmann-type control is that, owing to an instantaneous binary control formulation, it permits the minimization of the cost functional to be embedded into the microscopic leaders' interactions of the corresponding Boltzmann equation. The related Fokker-Planck asymptotic limits are also derived, which allow one to give explicit expressions of stationary solutions. The results demonstrate the validity of the Boltzmann-type control approach and the capability of the leaders' control to strategically lead the followers' opinion.

  16. Events & Opinion: A Report to Our Readers.

    ERIC Educational Resources Information Center

    Green, Joseph H.

    1995-01-01

    Reprints an article originally published in 1957. Surveys readers of the journal. Notes that readers felt that 89% of the articles were either very good or excellent. Lists readers' views of pressing educational issues. (RS)

  17. Cis-Golgi cisternal assembly and biosynthetic activation occur sequentially in plants and algae.

    PubMed

    Donohoe, Bryon S; Kang, Byung-Ho; Gerl, Mathias J; Gergely, Zachary R; McMichael, Colleen M; Bednarek, Sebastian Y; Staehelin, L Andrew

    2013-05-01

    The cisternal progression/maturation model of Golgi trafficking predicts that cis-Golgi cisternae are formed de novo on the cis-side of the Golgi. Here we describe structural and functional intermediates of the cis cisterna assembly process in high-pressure frozen algae (Scherffelia dubia, Chlamydomonas reinhardtii) and plants (Arabidopsis thaliana, Dionaea muscipula; Venus flytrap) as determined by electron microscopy, electron tomography and immuno-electron microscopy techniques. Our findings are as follows: (i) The cis-most (C1) Golgi cisternae are generated de novo from cisterna initiators produced by the fusion of 3-5 COPII vesicles in contact with a C2 cis cisterna. (ii) COPII vesicles fuel the growth of the initiators, which then merge into a coherent C1 cisterna. (iii) When a C1 cisterna nucleates its first cisterna initiator it becomes a C2 cisterna. (iv) C2-Cn cis cisternae grow through COPII vesicle fusion. (v) ER-resident proteins are recycled from cis cisternae to the ER via COPIa-type vesicles. (vi) In S. dubia the C2 cisternae are capable of mediating the self-assembly of scale protein complexes. (vii) In plants, ∼90% of native α-mannosidase I localizes to medial Golgi cisternae. (viii) Biochemical activation of cis cisternae appears to coincide with their conversion to medial cisternae via recycling of medial cisterna enzymes. We propose how the different cis cisterna assembly intermediates of plants and algae may actually be related to those present in the ERGIC and in the pre-cis Golgi cisterna layer in mammalian cells.

  18. Cis-Golgi cisternal assembly and biosynthetic activation occur sequentially in plants and algae

    PubMed Central

    Donohoe, Bryon S.; Kang, Byung-Ho; Gerl, Mathias J.; Gergely, Zachary R.; McMichael, Colleen M.; Bednarek, Sebastian Y.; Staehelin, L. Andrew

    2013-01-01

    The cisternal progression/maturation model of Golgi trafficking predicts that cis-Golgi cisternae are formed de novo on the cis-side of the Golgi. Here we describe structural and functional intermediates of the cis cisterna assembly process in high-pressure frozen algae (Scherffelia dubia, Chlamydomonas reinhardtii) and plants (Arabidopsis thaliana, Dionaea muscipula; Venus Flytrap) as determined by electron microscopy, electron tomography and immuno-electron microscopy techniques. Our findings are as follows: (1) The cis-most (C1) Golgi cisternae are generated de novo from cisterna initiators produced by the fusion of 3–5 COPII vesicles in contact with a C2 cis cisterna. (2) COPII vesicles fuel the growth of the initiators, which then merge into a coherent C1 cisterna. (3) When a C1 cisterna nucleates its first cisterna initiator it becomes a C2 cisterna. (4) C2-Cn cis cisternae grow through COPII vesicle fusion. (5) ER-resident proteins are recycled from cis cisternae to the ER via COPIa-type vesicles. (6) In S. dubia the C2 cisternae are capable of mediating the self-assembly of scale protein complexes. (7) In plants, ~90% of native α-mannosidase I localizes to medial Golgi cisternae. (8) Biochemical activation of cis cisternae appears to coincide with their conversion to medial cisternae via recycling of medial cisterna enzymes. We propose how the different cis cisterna assembly intermediates of plants and algae may actually be related to those present in the ERGIC and in the pre-cis Golgi cisterna layer in mammalian cells. PMID:23369235

  19. 9-cis β-Carotene Increased Cholesterol Efflux to HDL in Macrophages

    PubMed Central

    Bechor, Sapir; Zolberg Relevy, Noa; Harari, Ayelet; Almog, Tal; Kamari, Yehuda; Ben-Amotz, Ami; Harats, Dror; Shaish, Aviv

    2016-01-01

    Cholesterol efflux from macrophages is a key process in reverse cholesterol transport and, therefore, might inhibit atherogenesis. 9-cis-β-carotene (9-cis-βc) is a precursor for 9-cis-retinoic-acid (9-cis-RA), which regulates macrophage cholesterol efflux. Our objective was to assess whether 9-cis-βc increases macrophage cholesterol efflux and induces the expression of cholesterol transporters. Enrichment of a mouse diet with βc from the alga Dunaliella led to βc accumulation in peritoneal macrophages. 9-cis-βc increased the mRNA levels of CYP26B1, an enzyme that regulates RA cellular levels, indicating the formation of RA from βc in RAW264.7 macrophages. Furthermore, 9-cis-βc, as well as all-trans-βc, significantly increased cholesterol efflux to high-density lipoprotein (HDL) by 50% in RAW264.7 macrophages. Likewise, food fortification with 9-cis-βc augmented cholesterol efflux from macrophages ex vivo. 9-cis-βc increased both the mRNA and protein levels of ABCA1 and apolipoprotein E (APOE) and the mRNA level of ABCG1. Our study shows, for the first time, that 9-cis-βc from the diet accumulates in peritoneal macrophages and increases cholesterol efflux to HDL. These effects might be ascribed to transcriptional induction of ABCA1, ABCG1, and APOE. These results highlight the beneficial effect of βc in inhibition of atherosclerosis by improving cholesterol efflux from macrophages. PMID:27447665

  20. Application of CIS to high-efficiency PV module fabrication. Phase 3 final technical report

    SciTech Connect

    Basol, B M; Kapur, V K; Leidholm, C R; Halani, A; Roe, R; Norsworthy, G

    1998-08-01

    During this research period, researchers at International Solar Electric Technology (ISET) concentrated their efforts on three different areas of research. Within the National CIS R and D Team, ISET participated in the substrate/Mo interactions working group and investigated issues such as Na diffusion from the soda-lime glass substrate into the Mo layers and CIS films. Researchers determined that the Na content within the Mo layers was not a strong function of the nature of the Mo film. However, they found that diffusion through the Mo layers was a function of the Mo film characteristics as well as a very strong function of the CIS growth process itself. Researchers showed conclusively that the Na resided on the grain boundaries of CIS layers. Another team activity involved evaluation of CdS-free CIS solar cells. ZnO/CIS junctions prepared by the two-stage process showed light-soaking effects. Cells left under illumination improved in efficiency and were similar to the CdS/CIS junctions. After storage in the dark, however, efficiency deteriorated greatly for the ZnO/CIS device, most of the decline coming from the open-circuit voltage values. Much of the effort during this period was spent on developing a low-cost, non-vacuum CIS deposition technique. The method developed involves particulate deposition and formation of precursor layers followed by the conversion of these layers into CIS. Test modules of 40--60 cm{sup 2} were adapted to understand the issues involved in this novel technology. At the present time, the submodule efficiencies are 6--7%. Single-cell efficiencies are in the 10--13% range.

  1. 9-cis β-Carotene Increased Cholesterol Efflux to HDL in Macrophages.

    PubMed

    Bechor, Sapir; Zolberg Relevy, Noa; Harari, Ayelet; Almog, Tal; Kamari, Yehuda; Ben-Amotz, Ami; Harats, Dror; Shaish, Aviv

    2016-07-19

    Cholesterol efflux from macrophages is a key process in reverse cholesterol transport and, therefore, might inhibit atherogenesis. 9-cis-β-carotene (9-cis-βc) is a precursor for 9-cis-retinoic-acid (9-cis-RA), which regulates macrophage cholesterol efflux. Our objective was to assess whether 9-cis-βc increases macrophage cholesterol efflux and induces the expression of cholesterol transporters. Enrichment of a mouse diet with βc from the alga Dunaliella led to βc accumulation in peritoneal macrophages. 9-cis-βc increased the mRNA levels of CYP26B1, an enzyme that regulates RA cellular levels, indicating the formation of RA from βc in RAW264.7 macrophages. Furthermore, 9-cis-βc, as well as all-trans-βc, significantly increased cholesterol efflux to high-density lipoprotein (HDL) by 50% in RAW264.7 macrophages. Likewise, food fortification with 9-cis-βc augmented cholesterol efflux from macrophages ex vivo. 9-cis-βc increased both the mRNA and protein levels of ABCA1 and apolipoprotein E (APOE) and the mRNA level of ABCG1. Our study shows, for the first time, that 9-cis-βc from the diet accumulates in peritoneal macrophages and increases cholesterol efflux to HDL. These effects might be ascribed to transcriptional induction of ABCA1, ABCG1, and APOE. These results highlight the beneficial effect of βc in inhibition of atherosclerosis by improving cholesterol efflux from macrophages.

  2. Assembly and disassembly of the Golgi complex: two processes arranged in a cis-trans direction

    PubMed Central

    1992-01-01

    We have studied the disassembly and assembly of two morphologically and functionally distinct parts of the Golgi complex, the cis/middle and trans cisterna/trans network compartments. For this purpose we have followed the redistribution of three cis/middle- (GMPc-1, GMPc-2, MG 160) and two trans- (GMPt-1 and GMPt-2) Golgi membrane proteins during and after treatment of normal rat kidney (NRK) cells with brefeldin A (BFA). BFA induced complete disassembly of the cis/middle- and trans- Golgi complex and translocation of GMPc and GMPt to the ER. Cells treated for short times (3 min) with BFA showed extensive disorganization of both cis/middle- and trans-Golgi complexes. However, complete disorganization of the trans part required much longer incubations with the drug. Upon removal of BFA the Golgi complex was reassembled by a process consisting of three steps: (a) exist of cis/middle proteins from the ER and their accumulation into vesicular structures scattered throughout the cytoplasm; (b) gradual relocation and accumulation of the trans proteins in the vesicles containing the cis/middle proteins; and (c) assembly of the cisternae, and reconstruction of the Golgi complex within an area located in the vicinity of the centrosome from which the ER was excluded. Reconstruction of the cis/middle-Golgi complex occurred under temperature conditions inhibitory of the reorganization of the trans- Golgi complex, and was dependent on microtubules. Reconstruction of the trans-Golgi complex, disrupted with nocodazole after selective fusion of the cis/middle-Golgi complex with the ER, occurred after the release of cis/middle-Golgi proteins from the ER and the assembly of the cis/middle cisternae. PMID:1730750

  3. Individual medication management system (IMMS) implementation in pharmacists' opinion.

    PubMed

    Waszyk-Nowaczyk, Magdalena; Lawicki, Sebastian; Michalak, Michał; Simon, Marek

    2014-01-01

    Many countries of the world including Poland, are taking actions for improving the role of the pharmacist as a health care professional. One of those is implementation of pharmaceutical care (PC), as a documented specialist medical service, which also includes pharmacist interventions, such as preparing Individual Medication Management System (IMMS), to enhance patient's adherence. Because of the chance to monitor the dosage and to detect and prevent drug problems occurrence, IMMS is thought to be an opportunity for individualized, effective and safe patient's pharmacotherapy. The aim of the study was to define pharmacists' attitudes toward IMMS. The study included also the evaluation of pharmacist-physician cooperation to determine whether IMMS can improve partnership among health care professionals for proper patient's care. The survey was conducted in Poznań, between June 2011 and March 2012. An anonymous questionnaire was delivered personally to pharmacists. Each questionnaire was provided with a short information brochure attached and presentation of demos how to use IMMS. The survey covered 129 pharmacists (76.7% women and 23.3% men) where 48.8% had up to 5 years length of service as a pharmacist, 24.8% - 6-10 years, 14.9% - 11-20 years and 11.5% - 21 and more years. Most of the participants did not have specialization (80.6%) and only 5.4% had Ph.D. degree. Survey confirmed that 64.8% of pharmacists (p < 0.0001), mainly with the shortest length of service (p = 0.02268) and without specialty (p = 0.00244) didn't cooperate with physicians, but 68.8% of respondents emphasized that the range of cooperation could increase by IMMS application (p < 0.00001). About 50.0% of respondents' considered that patients would be interested in IMMS usage (p = 0.00079) and in 71.9% opinions, it would attach the patient to specific community pharmacy (p < 0.00001). This statement was confirmed by respondents with the shortest length of services (p = 0.00659). Proposed dosing

  4. Opinion Formation by Social Influence: From Experiments to Modeling

    PubMed Central

    Chacoma, Andrés; Zanette, Damián H.

    2015-01-01

    Predicting different forms of collective behavior in human populations, as the outcome of individual attitudes and their mutual influence, is a question of major interest in social sciences. In particular, processes of opinion formation have been theoretically modeled on the basis of a formal similarity with the dynamics of certain physical systems, giving rise to an extensive collection of mathematical models amenable to numerical simulation or even to exact solution. Empirical ground for these models is however largely missing, which confine them to the level of mere metaphors of the real phenomena they aim at explaining. In this paper we present results of an experiment which quantifies the change in the opinions given by a subject on a set of specific matters under the influence of others. The setup is a variant of a recently proposed experiment, where the subject’s confidence on his or her opinion was evaluated as well. In our realization, which records the quantitative answers of 85 subjects to 20 questions before and after an influence event, the focus is put on characterizing the change in answers and confidence induced by such influence. Similarities and differences with the previous version of the experiment are highlighted. We find that confidence changes are to a large extent independent of any other recorded quantity, while opinion changes are strongly modulated by the original confidence. On the other hand, opinion changes are not influenced by the initial difference with the reference opinion. The typical time scales on which opinion varies are moreover substantially longer than those of confidence change. Experimental results are then used to estimate parameters for a dynamical agent-based model of opinion formation in a large population. In the context of the model, we study the convergence to full consensus and the effect of opinion leaders on the collective distribution of opinions. PMID:26517825

  5. Opinion Formation by Social Influence: From Experiments to Modeling.

    PubMed

    Chacoma, Andrés; Zanette, Damián H

    2015-01-01

    Predicting different forms of collective behavior in human populations, as the outcome of individual attitudes and their mutual influence, is a question of major interest in social sciences. In particular, processes of opinion formation have been theoretically modeled on the basis of a formal similarity with the dynamics of certain physical systems, giving rise to an extensive collection of mathematical models amenable to numerical simulation or even to exact solution. Empirical ground for these models is however largely missing, which confine them to the level of mere metaphors of the real phenomena they aim at explaining. In this paper we present results of an experiment which quantifies the change in the opinions given by a subject on a set of specific matters under the influence of others. The setup is a variant of a recently proposed experiment, where the subject's confidence on his or her opinion was evaluated as well. In our realization, which records the quantitative answers of 85 subjects to 20 questions before and after an influence event, the focus is put on characterizing the change in answers and confidence induced by such influence. Similarities and differences with the previous version of the experiment are highlighted. We find that confidence changes are to a large extent independent of any other recorded quantity, while opinion changes are strongly modulated by the original confidence. On the other hand, opinion changes are not influenced by the initial difference with the reference opinion. The typical time scales on which opinion varies are moreover substantially longer than those of confidence change. Experimental results are then used to estimate parameters for a dynamical agent-based model of opinion formation in a large population. In the context of the model, we study the convergence to full consensus and the effect of opinion leaders on the collective distribution of opinions.

  6. Public opinion on abortion in Mexico City after the landmark reform.

    PubMed

    Wilson, Kate S; García, Sandra G; Díaz Olavarrieta, Claudia; Villalobos-Hernández, Aremis; Rodríguez, Jorge Valencia; Smith, Patricio Sanhueza; Burks, Courtney

    2011-09-01

    This article presents findings from three opinion surveys conducted among representative samples of Mexico City residents: the first one immediately prior to the groundbreaking legalization of first-trimester abortion in April 2007, and one and two years after the reform. Bivariate and multivariate analyses were performed to assess changes in opinion concerning abortion and correlates of favorable opinion following reform. In 2009 a clear majority (74 percent) of respondents were in support of the Mexico City law allowing for elective first-trimester abortion, compared with 63 percent in 2008 and 38 percent in 2007. A significant increase in support for extending the law to the rest of Mexico was found: from 51 percent in 2007 to 70 percent in 2008 and 83 percent in 2009. In 2008 the significant independent correlates of support for the Mexico City law were education, infrequent religious service attendance, sex (being male), and political party affiliation; in 2009 they were education beyond high school, infrequent religious service attendance, and ever having been married.

  7. A Tale of Two Counties: Natives' Opinions Toward Immigration in North Carolina.

    PubMed

    O'Neil, Kevin; Tienda, Marta

    2010-01-01

    This paper compares native residents' opinions and perceptions regarding immigration using a representative survey from a pair of matched North Carolina counties-one that experienced recent growth of its foreign-born population and one that did not. Drawing from several theoretical perspectives, including group threat, contact theory, and symbolic politics, we formulate and empirically evaluate several hypotheses. Results provide limited evidence that competition and threat influence formation of opinions about immigration, with modest support for claims that parents with school-aged children harbor more negative views of immigration than their childless counterparts. Except for residents in precarious economic situations, these negative opinions appear unrelated to the immigrant composition of the community. Claims that the media promotes negative views of immigration receive limited support, but this relationship is unrelated to the volume of local immigration. Finally, sustained contacts with foreign-born residents outside work environments are associated with positive views of immigration, but superficial contacts appear to be conducive to anti-immigration sentiments. Political orientation, educational attainment and indicators of respondents' tolerance for diversity explain most of the difference between the two counties in overall support for immigration.

  8. A Tale of Two Counties: Natives’ Opinions Toward Immigration in North Carolina

    PubMed Central

    O’Neil, Kevin; Tienda, Marta

    2013-01-01

    This paper compares native residents’ opinions and perceptions regarding immigration using a representative survey from a pair of matched North Carolina counties—one that experienced recent growth of its foreign-born population and one that did not. Drawing from several theoretical perspectives, including group threat, contact theory, and symbolic politics, we formulate and empirically evaluate several hypotheses. Results provide limited evidence that competition and threat influence formation of opinions about immigration, with modest support for claims that parents with school-aged children harbor more negative views of immigration than their childless counterparts. Except for residents in precarious economic situations, these negative opinions appear unrelated to the immigrant composition of the community. Claims that the media promotes negative views of immigration receive limited support, but this relationship is unrelated to the volume of local immigration. Finally, sustained contacts with foreign-born residents outside work environments are associated with positive views of immigration, but superficial contacts appear to be conducive to anti-immigration sentiments. Political orientation, educational attainment and indicators of respondents’ tolerance for diversity explain most of the difference between the two counties in overall support for immigration. PMID:23436953

  9. Public opinion towards supervised injection facilities and heroin-assisted treatment in Ontario, Canada.

    PubMed

    Cruz, Michelle Firestone; Patra, Jayadeep; Fischer, Benedikt; Rehm, Jürgen; Kalousek, Kate

    2007-01-01

    In recent years, controversial interventions such as 'heroin-assisted treatment' (HAT) and 'supervised injection facilities' (SIFs) have been established in attempts to minimise the high morbidity and mortality consequences of illicit drug use. This paper examines public opinion towards HAT and SIF using data from the 2003 Centre for Addiction and Mental Health (CAMH) Monitor, a representative population survey conducted among adults residing in Ontario, Canada. Data relating specifically to SIFs and HAT were isolated from the main database (n=885); agreement scores were collapsed to create a scale and analysed using independent sample t-tests and ANOVAs. Results revealed that 60 percent (n=530) of the sample agreed that SIFs should be made available to injection drug users, while 40 percent (n=355) disagreed. When asked about the provision of HAT, a similar pattern emerged. Variables significantly associated with positive opinions toward SIFs and HAT were: income; higher education; the use of cocaine or cannabis within the last 12 months; being in favour of cannabis decriminalisation; support of needle exchange in prison; view of illicit drug users as ill people; and agreement that drug users are in need of public support. Given the current political climate and the tentative position of SIFs and HAT in Canada, understanding the public's opinion is crucial for the feasibility and long-term sustainability of these interventions.

  10. Public opinion on nutrition-related policies to combat child obesity, Los Angeles County, 2011.

    PubMed

    Simon, Paul A; Chiang, Choiyuk; Lightstone, Amy S; Shih, Margaret

    2014-06-05

    We assessed public opinion on nutrition-related policies to address child obesity: a soda tax, restrictions on advertising unhealthy foods and beverages to children, and restrictions on siting fast food restaurants and convenience stores near schools. We analyzed data from 998 adults (aged ≥18 years) in the 2011 Los Angeles County Health Survey. Support was highest for advertising restrictions (74%), intermediate for a soda tax (60%), and lowest for siting restrictions on fast food restaurants and convenience stores (44% and 37%, respectively). Support for food and beverage advertising restrictions and soda taxation is promising for future policy efforts to address child obesity.

  11. Exploring abortion knowledge and opinion among lawyers, an important yet overlooked stakeholder group in Mexico.

    PubMed

    Wilson, Kate S; Garcia, Sandra G; Olavarrieta, Claudia Díaz; McMurtrie, Stephanie M; Valencia, Jorge Armando; Diaz de Leon, Fernanda; Sanchez Fuentes, Maria Luisa

    2012-01-01

    Lawyers are important actors shaping the abortion debate in Mexico. Of 250 private and public sector criminal lawyers surveyed from four regions, the majority knew about abortion laws in their states. At least 80% agreed with abortion in cases of rape, risk to a woman's life or health, and fetal malformations. Overall, 61% agreed with the Mexico City law and 84% would defend a woman denied a legal abortion. In multivariate analysis, being very knowledgeable of abortion laws was a significant predictor of more "progressive" abortion opinions, support for the Mexico City law, and support for the health indication.

  12. [Medical opinions on fatal auto-erotic accidents for insurance purposes (author's transl)].

    PubMed

    Naeve, W

    1975-01-01

    The problematic nature of medico-legal opinions on fatal auto-erotic accidents made for private accident insurance companies is outlined in a survey based on our own records. Taking the "General Insuranc Terms for Accident Insurance" (AUB) into consideration, guidelines for the forming of such opinions are given. One is warned not to form summary opinions. Decisive is the insured's state of conciousness when the accident was triggered. Only in exceptional cases can an insurance covered accident be rejected because of a body injury inflicted by the insured on himself (see article). These actions do not usually result in external injury to the body. Experience proves that "ideal conditions" for forming an opinion are rarely given. Also, the nature of the death situation is such that often the corpse is discovered only days after death. From the outset, forming a medical opinion is beset with varying degrees of difficulty depending upon which category of auto-erotic activities the accident falls into: 1. direct stimulation of the erotic regions, 2. stimulation of sexual centers in the central nervous system, 3. the creation of fear and anguish in the context of masochistic perversion. According the presently valid insurance terms (AUB), cases of auto-erotic electrocution are to be regarded as covered. A disturbance of consciousness--with the exception of such disturbances following the influence of alcohol, medicines or narcotics--cannot be assumed for the moment in which the accident was triggered. At this moment body "integrity" was also intact. Accidents through strangulation, respectively asphyxiation (plastic bags etc.), usually occur during a disturbance of consciousness of the victim. This disturbance is the result of cerebral hypoxia, that is a result of strangulation, respectively external respiratory obstruction. The forming of a medical opinion for insurance purposes on auto-erotic accidents with clearly recognizable masochistic tendency is particularly

  13. Determination of 9-cis beta-carotene and zeta-carotene in biological samples.

    PubMed

    Qin, Jian; Yeum, Kyung-Jin; Johnson, Elizabeth J; Krinsky, Norman I; Russell, Robert M; Tang, Guangwen

    2008-09-01

    Concentrations of 9-cis beta-carotene (9-cis betaC) and zeta-carotene (zetaC) in biological samples may provide crucial information on the biological activities of these carotenoids. However, in high-performance liquid chromatography (HPLC) these carotenoids are often co-eluted. Therefore, there is an urgent need to develop a method for 9-cis betaC and zetaC quantitation. Both 9-cis betaC and zetaC have peak absorbance at 400 and 450 nm, respectively, whereas only 9-cis betaC has peak absorbance at 475 nm. We developed a HPLC method to quantitate 9-cis betaC and zetaC by using peak absorbance ratios. The 9-cis betaC/zetaC peak area was monitored at 475, 450 and 400 nm. The 9-cis betaC was quantified by using absorbance value at 475 nm; zetaC was then calculated from the 9-cis betaC/zetaC peak at 400 nm by subtracting 9-cis betaC contribution at 400 nm using the 400-nm/475-nm peak absorbance ratio of 9-cis betaC (0.39). This method was applied to determine 9-cis betaC and zetaC concentrations in serum and breast milk samples (n=12) from American lactating women and serum and breast adipose tissue samples (n=16) from Korean women with either benign or malignant breast tumors. 9-cis betaC concentrations in serum and breast milk of American women, and serum and adipose tissue of Korean women were 7.1+/-0.8 and 1.1+/-0.2 nM, and 15.6+/-1.1 nM and 0.2+/-0.1 nmol/g, respectively. zetaC concentrations in the above samples were 54.2+/-7.2 and 8.3+/-1.8 nM, and 49.0+/-3.9 nM and 0.3+/-0.1 nmol/g, respectively.

  14. Clinicians' opinions on new vaccination programs implementation.

    PubMed

    Dubé, E; Gilca, V; Sauvageau, C; Bettinger, J A; Boucher, F D; McNeil, S; Gemmill, I; Lavoie, F; Ouakki, M; Boulianne, N

    2012-06-29

    In Canada, several new vaccines were recently approved for clinical use or are expected to be soon. Decision-makers are faced with the choice whether or not to include these vaccines in publicly funded vaccination programs. The aim of this study was to assess Canadian pediatricians' and family physicians' opinions regarding 7 new vaccines, and perceived priority for the introduction of new programs. A self-administered, anonymous, mail-based questionnaire was sent during fall 2009 to a random sample of 1182 family physicians and to all 1852 Canadian pediatricians. Responses to 8 statements regarding frequency and severity of the diseases, efficacy and safety of the vaccines as well as feasibility of immunization programs were used to calculate priority scores to rank the 7 potential new vaccination programs (calculated scores ranging from 0 to 100). Overall response rate was 43%. The majority of respondents perceived the health and economic burden of diseases prevented by the seven new vaccines as important and considered new vaccines to be safe and effective. More than 90% of physicians strongly agreed or agreed that the new vaccines would be or are currently well accepted by the public and by the health professionals who administer vaccines, except for the HPV and rotavirus vaccines (respectively 30% and 29% strongly agreed or agreed). Mean priority scores were: 77.4 out of 100 for the measles, mumps, rubella and varicella (MMRV) combined vaccine; 75.6 for the hexavalent (DTaP-IPV-Hib-HBV) vaccine; 73.1 for the new pneumococcal conjugate vaccines; 69.8 for the meningococcal ACYW135; 68.9 for the combined hepatitis A and B; 63.5 for the human papillomavirus vaccine and 56.9 for the rotavirus vaccine. Health professionals' opinion is an important element to consider in the decision-making process regarding implementation of new immunization programs. Without health professional support, the introduction of a new vaccination program may be unsuccessful. In this

  15. Low Thrust, Deep Throttling, US/CIS Integrated NTRE

    NASA Astrophysics Data System (ADS)

    Culver, Donald W.; Kolganov, Vyacheslav; Rochow, Richard F.

    1994-07-01

    In 1993 our international team performed a follow-on ``Nuclear Thermal Rocket Engine (NTRE) Extended Life Feasibility Assessment'' study for the Nuclear Propulsion Office (NPO) at NASAs Lewis Research Center. The main purpose of this study was to complete the 1992 study matrix to assess NTRE designs at thrust levels of 22.5, 11.3, and 6.8 tonnes, using Commonwealth of Independent States (CIS) reactor technology. An additional Aerojet goal was to continue improving the NTRE concept we had generated. Deep throttling, mission performance optimized engine design parametrics, and reliability/cost enhancing engine system simplifications were studied, because they seem to be the last three basic design improvements sorely needed by post-NERVA NTRE. Deep throttling improves engine life by eliminating damaging thermal and mechanical shocks caused by after-cooling with pulsed coolant flow. Alternately, it improves mission performance with steady flow after-cooling by minimizing reactor over-cooling. Deep throttling also provides a practical transition from high pressures and powers of the high thrust power cycle to the low pressures and powers of our electric power generating mode. Two deep throttling designs are discussed; a workable system that was studied and a simplified system that is recommended for future study. Mission-optimized engine thrust/weight (T/W) and Isp predictions are included along with system flow schemes and concept sketches.

  16. Detailed map of a cis-regulatory input function

    NASA Astrophysics Data System (ADS)

    Setty, Y.; Mayo, A. E.; Surette, M. G.; Alon, U.

    2003-06-01

    Most genes are regulated by multiple transcription factors that bind specific sites in DNA regulatory regions. These cis-regulatory regions perform a computation: the rate of transcription is a function of the active concentrations of each of the input transcription factors. Here, we used accurate gene expression measurements from living cell cultures, bearing GFP reporters, to map in detail the input function of the classic lacZYA operon of Escherichia coli, as a function of about a hundred combinations of its two inducers, cAMP and isopropyl -D-thiogalactoside (IPTG). We found an unexpectedly intricate function with four plateau levels and four thresholds. This result compares well with a mathematical model of the binding of the regulatory proteins cAMP receptor protein (CRP) and LacI to the lac regulatory region. The model is also used to demonstrate that with few mutations, the same region could encode much purer AND-like or even OR-like functions. This possibility means that the wild-type region is selected to perform an elaborate computation in setting the transcription rate. The present approach can be generally used to map the input functions of other genes.

  17. Assessing Computational Methods of Cis-Regulatory Module Prediction

    PubMed Central

    Su, Jing; Teichmann, Sarah A.; Down, Thomas A.

    2010-01-01

    Computational methods attempting to identify instances of cis-regulatory modules (CRMs) in the genome face a challenging problem of searching for potentially interacting transcription factor binding sites while knowledge of the specific interactions involved remains limited. Without a comprehensive comparison of their performance, the reliability and accuracy of these tools remains unclear. Faced with a large number of different tools that address this problem, we summarized and categorized them based on search strategy and input data requirements. Twelve representative methods were chosen and applied to predict CRMs from the Drosophila CRM database REDfly, and across the human ENCODE regions. Our results show that the optimal choice of method varies depending on species and composition of the sequences in question. When discriminating CRMs from non-coding regions, those methods considering evolutionary conservation have a stronger predictive power than methods designed to be run on a single genome. Different CRM representations and search strategies rely on different CRM properties, and different methods can complement one another. For example, some favour homotypical clusters of binding sites, while others perform best on short CRMs. Furthermore, most methods appear to be sensitive to the composition and structure of the genome to which they are applied. We analyze the principal features that distinguish the methods that performed well, identify weaknesses leading to poor performance, and provide a guide for users. We also propose key considerations for the development and evaluation of future CRM-prediction methods. PMID:21152003

  18. Using hexamers to predict cis-regulatory motifs in Drosophila

    PubMed Central

    Chan, Bob Y; Kibler, Dennis

    2005-01-01

    Background Cis-regulatory modules (CRMs) are short stretches of DNA that help regulate gene expression in higher eukaryotes. They have been found up to 1 megabase away from the genes they regulate and can be located upstream, downstream, and even within their target genes. Due to the difficulty of finding CRMs using biological and computational techniques, even well-studied regulatory systems may contain CRMs that have not yet been discovered. Results We present a simple, efficient method (HexDiff) based only on hexamer frequencies of known CRMs and non-CRM sequence to predict novel CRMs in regulatory systems. On a data set of 16 gap and pair-rule genes containing 52 known CRMs, predictions made by HexDiff had a higher correlation with the known CRMs than several existing CRM prediction algorithms: Ahab, Cluster Buster, MSCAN, MCAST, and LWF. After combining the results of the different algorithms, 10 putative CRMs were identified and are strong candidates for future study. The hexamers used by HexDiff to distinguish between CRMs and non-CRM sequence were also analyzed and were shown to be enriched in regulatory elements. Conclusion HexDiff provides an efficient and effective means for finding new CRMs based on known CRMs, rather than known binding sites. PMID:16253142

  19. Multigenome DNA sequence conservation identifies Hox cis-regulatory elements

    PubMed Central

    Kuntz, Steven G.; Schwarz, Erich M.; DeModena, John A.; De Buysscher, Tristan; Trout, Diane; Shizuya, Hiroaki; Sternberg, Paul W.; Wold, Barbara J.

    2008-01-01

    To learn how well ungapped sequence comparisons of multiple species can predict cis-regulatory elements in Caenorhabditis elegans, we made such predictions across the large, complex ceh-13/lin-39 locus and tested them transgenically. We also examined how prediction quality varied with different genomes and parameters in our comparisons. Specifically, we sequenced ∼0.5% of the C. brenneri and C. sp. 3 PS1010 genomes, and compared five Caenorhabditis genomes (C. elegans, C. briggsae, C. brenneri, C. remanei, and C. sp. 3 PS1010) to find regulatory elements in 22.8 kb of noncoding sequence from the ceh-13/lin-39 Hox subcluster. We developed the MUSSA program to find ungapped DNA sequences with N-way transitive conservation, applied it to the ceh-13/lin-39 locus, and transgenically assayed 21 regions with both high and low degrees of conservation. This identified 10 functional regulatory elements whose activities matched known ceh-13/lin-39 expression, with 100% specificity and a 77% recovery rate. One element was so well conserved that a similar mouse Hox cluster sequence recapitulated the native nematode expression pattern when tested in worms. Our findings suggest that ungapped sequence comparisons can predict regulatory elements genome-wide. PMID:18981268

  20. A Cis-Regulatory Map of the Drosophila Genome

    PubMed Central

    Nègre, Nicolas; Brown, Christopher D.; Ma, Lijia; Bristow, Christopher Aaron; Miller, Steven W.; Wagner, Ulrich; Kheradpour, Pouya; Eaton, Matthew L.; Loriaux, Paul; Sealfon, Rachel; Li, Zirong; Ishii, Haruhiko; Spokony, Rebecca F.; Chen, Jia; Hwang, Lindsay; Cheng, Chao; Auburn, Richard P.; Davis, Melissa B.; Domanus, Marc; Shah, Parantu K.; Morrison, Carolyn A.; Zieba, Jennifer; Suchy, Sarah; Senderowicz, Lionel; Victorsen, Alec; Bild, Nicholas A.; Grundstad, A. Jason; Hanley, David; MacAlpine, David M.; Mannervik, Mattias; Venken, Koen; Bellen, Hugo; White, Robert; Russell, Steven; Grossman, Robert L.; Ren, Bing; Gerstein, Mark; Posakony, James W.; Kellis, Manolis; White, Kevin P.

    2011-01-01

    Systematic annotation of gene regulatory elements is a major challenge in genome science. Direct mapping of chromatin modification marks and transcriptional factor binding sites genome-wide 1,2 has successfully identified specific subtypes of regulatory elements 3. In Drosophila several pioneering studies have provided genome-wide identification of Polycomb-Response Elements 4, chromatin states 5, transcription factor binding sites (TFBS) 6–9, PolII regulation 8, and insulator elements 10; however, comprehensive annotation of the regulatory genome remains a significant challenge. Here we describe results from the modENCODE cis-regulatory annotation project. We produced a map of the Drosophila melanogaster regulatory genome based on more than 300 chromatin immuno-precipitation (ChIP) datasets for eight chromatin features, five histone deacetylases (HDACs) and thirty-eight site-specific transcription factors (TFs) at different stages of development. Using these data we inferred more than 20,000 candidate regulatory elements and we validated a subset of predictions for promoters, enhancers, and insulators in vivo. We also identified nearly 2,000 genomic regions of dense TF binding associated with chromatin activity and accessibility. We discovered hundreds of new TF co-binding relationships and defined a TF network with over 800 potential regulatory relationships. PMID:21430782