Nilpotent representations of classical quantum groups at roots of unity

DOE Office of Scientific and Technical Information (OSTI.GOV)

Abe, Yuuki; Nakashima, Toshiki

2005-11-01

Properly specializing the parameters in 'Schnizer modules', for types A,B,C, and D, we get its unique primitive vector. Then we show that the module generated by the primitive vector is an irreducible highest weight module of finite dimensional classical quantum groups at roots of unity.

Theory of low-power ultra-broadband terahertz sideband generation in bi-layer graphene.

PubMed

Crosse, J A; Xu, Xiaodong; Sherwin, Mark S; Liu, R B

2014-09-24

In a semiconductor illuminated by a strong terahertz (THz) field, optically excited electron-hole pairs can recombine to emit light in a broad frequency comb evenly spaced by twice the THz frequency. Such high-order THz sideband generation is of interest both as an example of extreme nonlinear optics and also as a method for ultrafast electro-optical modulation. So far, this phenomenon has only been observed with large field strengths (~10 kV cm(-1)), an obstacle for technological applications. Here we predict that bi-layer graphene generates high-order sidebands at much weaker THz fields. We find that a THz field of strength 1 kV cm(-1) can produce a high-sideband spectrum of about 30 THz, 100 times broader than in GaAs. The sidebands are generated despite the absence of classical collisions, with the quantum coherence of the electron-hole pairs enabling recombination. These remarkable features lower the barrier to desktop electro-optical modulation at THz frequencies, facilitating ultrafast optical communications.

Double-image storage optimized by cross-phase modulation in a cold atomic system

NASA Astrophysics Data System (ADS)

Qiu, Tianhui; Xie, Min

2017-09-01

A tripod-type cold atomic system driven by double-probe fields and a coupling field is explored to store double images based on the electromagnetically induced transparency (EIT). During the storage time, an intensity-dependent signal field is applied further to extend the system with the fifth level involved, then the cross-phase modulation is introduced for coherently manipulating the stored images. Both analytical analysis and numerical simulation clearly demonstrate a tunable phase shift with low nonlinear absorption can be imprinted on the stored images, which effectively can improve the visibility of the reconstructed images. The phase shift and the energy retrieving rate of the probe fields are immune to the coupling intensity and the atomic optical density. The proposed scheme can easily be extended to the simultaneous storage of multiple images. This work may be exploited toward the end of EIT-based multiple-image storage devices for all-optical classical and quantum information processings.

Role of inhibitory control in modulating focal seizure spread.

PubMed

Liou, Jyun-You; Ma, Hongtao; Wenzel, Michael; Zhao, Mingrui; Baird-Daniel, Eliza; Smith, Elliot H; Daniel, Andy; Emerson, Ronald; Yuste, Rafael; Schwartz, Theodore H; Schevon, Catherine A

2018-05-10

Focal seizure propagation is classically thought to be spatially contiguous. However, distribution of seizures through a large-scale epileptic network has been theorized. Here, we used a multielectrode array, wide field calcium imaging, and two-photon calcium imaging to study focal seizure propagation pathways in an acute rodent neocortical 4-aminopyridine model. Although ictal neuronal bursts did not propagate beyond a 2-3-mm region, they were associated with hemisphere-wide field potential fluctuations and parvalbumin-positive interneuron activity outside the seizure focus. While bicuculline surface application enhanced contiguous seizure propagation, focal bicuculline microinjection at sites distant to the 4-aminopyridine focus resulted in epileptic network formation with maximal activity at the two foci. Our study suggests that both classical and epileptic network propagation can arise from localized inhibition defects, and that the network appearance can arise in the context of normal brain structure without requirement for pathological connectivity changes between sites.

Coupling of a nanomechanical oscillator and an atomic three-level medium

NASA Astrophysics Data System (ADS)

Sanz-Mora, A.; Eisfeld, A.; Wüster, S.; Rost, J.-M.

2016-02-01

We theoretically investigate the coupling of an ultracold three-level atomic gas and a nanomechanical mirror via classical electromagnetic radiation. The radiation pressure on the mirror is modulated by absorption of a probe light field, caused by the atoms which are electromagnetically rendered nearly transparent, allowing the gas to affect the mirror. In turn, the mirror can affect the gas as its vibrations generate optomechanical sidebands in the control field. We show that the sidebands cause modulations of the probe intensity at the mirror frequency, which can be enhanced near atomic resonances. Through the radiation pressure from the probe beam onto the mirror, this results in resonant driving of the mirror. Controllable by the two-photon detuning, the phase relation of the driving to the mirror motion decides upon amplification or damping of mirror vibrations. This permits direct phase locking of laser amplitude modulations to the motion of a nanomechanical element opening a perspective for cavity-free cooling through coupling to an atomic gas.

GCR Modulation by Small-Scale Features in the Interplanetary Medium

NASA Astrophysics Data System (ADS)

Jordan, A. P.; Spence, H. E.; Blake, J. B.; Mulligan, T. L.; Shaul, D. N.; Galametz, M.

2007-12-01

In an effort to uncover the properties of structures in the interplanetary medium (IPM) that modulate galactic cosmic rays (GCR) on short time-scales (from hours to days), we study periods of differing conditions in the IPM. We analyze GCR variations from spacecraft both inside and outside the magnetosphere, using the High Sensitivity Telescope (HIST) on Polar and the Spectrometer for INTEGRAL (SPI). We seek causal correlations between the observed GCR modulations and structures in the solar wind plasma and interplanetary magnetic field, as measured concurrently with ACE and/or Wind. Our analysis spans time-/size-scale variations ranging from classic Forbush decreases (Fds), to substructure embedded within Fds, to much smaller amplitude and shorter duration variations observed during comparatively benign interplanetary conditions. We compare and contrast the conditions leading to the range of different GCR responses to modulating structures in the IPM.

Electric field feedback for Magneto(elasto)Electric magnetometer development

NASA Astrophysics Data System (ADS)

Yang, M.-T.; Zhuang, X.; Sing, M. Lam Chok; Dolabdjian, C.; Finkel, P.; Li, J.; Viehland, D.

2017-12-01

Magneto(elasto)Electric (ME) sensors based on magnetostrictive-piezoelectric composites have been investigated to evaluate their performances to sense a magnetic signal. Previous results have shown that the dielectric loss noise in the piezoelectric layer exhibits as the dominant intrinsic noise at low frequencies, which limits the sensor performances. Also, it has intrinsically no DC capability. To avoid a part of this limitation, modulation detection methods are evaluated through a frequency up-conversion technique [1-4]. Moreover, classical magnetic field feedback techniques can be used to increase the dynamic range, the sensing stability and the system linearity, too. In this paper, we propose a new method to feedback the system by using both the magneto-capacitance modulation and an electric field feedback technique. Our development shows the feasibility of the method and the results match with the theoretical description and material properties. Even if the present results are not totally satisfactory, they give the proof of concept and yield a way for the development of very low power magnetometers.

Intensity-modulated radiation therapy and volumetric-modulated arc therapy for adult craniospinal irradiation—A comparison with traditional techniques

DOE Office of Scientific and Technical Information (OSTI.GOV)

Studenski, Matthew T., E-mail: matthew.studenski@jeffersonhospital.org; Shen, Xinglei; Yu, Yan

2013-04-01

Craniospinal irradiation (CSI) poses a challenging planning process because of the complex target volume. Traditional 3D conformal CSI does not spare any critical organs, resulting in toxicity in patients. Here the dosimetric advantages of intensity-modulated radiation therapy (IMRT) and volumetric-modulated arc therapy (VMAT) are compared with classic conformal planning in adults for both cranial and spine fields to develop a clinically feasible technique that is both effective and efficient. Ten adult patients treated with CSI were retrospectively identified. For the cranial fields, 5-field IMRT and dual 356° VMAT arcs were compared with opposed lateral 3D conformal radiotherapy (3D-CRT) fields. Formore » the spine fields, traditional posterior-anterior (PA) PA fields were compared with isocentric 5-field IMRT plans and single 200° VMAT arcs. Two adult patients have been treated using this IMRT technique to date and extensive quality assurance, especially for the junction regions, was performed. For the cranial fields, the IMRT technique had the highest planned target volume (PTV) maximum and was the least efficient, whereas the VMAT technique provided the greatest parotid sparing with better efficiency. 3D-CRT provided the most efficient delivery but with the highest parotid dose. For the spine fields, VMAT provided the best PTV coverage but had the highest mean dose to all organs at risk (OAR). 3D-CRT had the highest PTV and OAR maximum doses but was the most efficient. IMRT provides the greatest OAR sparing but the longest delivery time. For those patients with unresectable disease that can benefit from a higher, definitive dose, 3D-CRT–opposed laterals are the most clinically feasible technique for cranial fields and for spine fields. Although inefficient, the IMRT technique is the most clinically feasible because of the increased mean OAR dose with the VMAT technique. Quality assurance of the beams, especially the junction regions, is essential.« less

Theory of low-power ultra-broadband terahertz sideband generation in bi-layer graphene

PubMed Central

Crosse, J. A.; Xu, Xiaodong; Sherwin, Mark S.; Liu, R. B.

2014-01-01

In a semiconductor illuminated by a strong terahertz (THz) field, optically excited electron–hole pairs can recombine to emit light in a broad frequency comb evenly spaced by twice the THz frequency. Such high-order THz sideband generation is of interest both as an example of extreme nonlinear optics and also as a method for ultrafast electro-optical modulation. So far, this phenomenon has only been observed with large field strengths (~10 kV cm−1), an obstacle for technological applications. Here we predict that bi-layer graphene generates high-order sidebands at much weaker THz fields. We find that a THz field of strength 1 kV cm−1 can produce a high-sideband spectrum of about 30 THz, 100 times broader than in GaAs. The sidebands are generated despite the absence of classical collisions, with the quantum coherence of the electron–hole pairs enabling recombination. These remarkable features lower the barrier to desktop electro-optical modulation at THz frequencies, facilitating ultrafast optical communications. PMID:25249245

Quantum propagation in single mode fiber

NASA Technical Reports Server (NTRS)

Joneckis, Lance G.; Shapiro, Jeffrey H.

1994-01-01

This paper presents a theory for quantum light propagation in a single-mode fiber which includes the effects of the Kerr nonlinearity, group-velocity dispersion, and linear loss. The theory reproduces the results of classical self-phase modulation, quantum four-wave mixing, and classical solution physics, within their respective regions of validity. It demonstrates the crucial role played by the Kerr-effect material time constant, in limiting the quantum phase shifts caused by the broadband zero-point fluctuations that accompany any quantized input field. Operator moment equations - approximated, numerically, via a terminated cumulant expansion - are used to obtain results for homodyne-measurement noise spectra when dispersion is negligible. More complicated forms of these equations can be used to incorporate dispersion into the noise calculations.

Does ℏ play a role in multidimensional spectroscopy? Reduced hierarchy equations of motion approach to molecular vibrations.

PubMed

Sakurai, Atsunori; Tanimura, Yoshitaka

2011-04-28

To investigate the role of quantum effects in vibrational spectroscopies, we have carried out numerically exact calculations of linear and nonlinear response functions for an anharmonic potential system nonlinearly coupled to a harmonic oscillator bath. Although one cannot carry out the quantum calculations of the response functions with full molecular dynamics (MD) simulations for a realistic system which consists of many molecules, it is possible to grasp the essence of the quantum effects on the vibrational spectra by employing a model Hamiltonian that describes an intra- or intermolecular vibrational motion in a condensed phase. The present model fully includes vibrational relaxation, while the stochastic model often used to simulate infrared spectra does not. We have employed the reduced quantum hierarchy equations of motion approach in the Wigner space representation to deal with nonperturbative, non-Markovian, and nonsecular system-bath interactions. Taking the classical limit of the hierarchy equations of motion, we have obtained the classical equations of motion that describe the classical dynamics under the same physical conditions as in the quantum case. By comparing the classical and quantum mechanically calculated linear and multidimensional spectra, we found that the profiles of spectra for a fast modulation case were similar, but different for a slow modulation case. In both the classical and quantum cases, we identified the resonant oscillation peak in the spectra, but the quantum peak shifted to the red compared with the classical one if the potential is anharmonic. The prominent quantum effect is the 1-2 transition peak, which appears only in the quantum mechanically calculated spectra as a result of anharmonicity in the potential or nonlinearity of the system-bath coupling. While the contribution of the 1-2 transition is negligible in the fast modulation case, it becomes important in the slow modulation case as long as the amplitude of the frequency fluctuation is small. Thus, we observed a distinct difference between the classical and quantum mechanically calculated multidimensional spectra in the slow modulation case where spectral diffusion plays a role. This fact indicates that one may not reproduce the experimentally obtained multidimensional spectrum for high-frequency vibrational modes based on classical molecular dynamics simulations if the modulation that arises from surrounding molecules is weak and slow. A practical way to overcome the difference between the classical and quantum simulations was discussed.

The OGLE Collection of Variable Stars. Classical, Type II, and Anomalous Cepheids toward the Galactic Center

NASA Astrophysics Data System (ADS)

Soszyński, I.; Udalski, A.; Szymański, M. K.; Wyrzykowski, Ł.; Ulaczyk, K.; Poleski, R.; Pietrukowicz, P.; Kozłowski, S.; Skowron, D. M.; Skowron, J.; Mróz, P.; Pawlak, M.; Rybicki, K.; Jacyszyn-Dobrzeniecka, A.

2017-12-01

We present a collection of classical, typeII, and anomalous Cepheids detected in the OGLE fields toward the Galactic center. The sample contains 87 classical Cepheids pulsating in one, two or three radial modes, 924 type II Cepheids divided into BL Her, W Vir, peculiar W Vir, and RV Tau stars, and 20 anomalous Cepheids - first such objects found in the Galactic bulge. Additionally, we upgrade the OGLE Collection of RR Lyr stars in the Galactic bulge by adding 828 newly identified variables. For all Cepheids and RRLyr stars, we publish time-series VI photometry obtained during the OGLE-IV project, from 2010 through 2017. We discuss basic properties of our classical pulsators: their spatial distribution, light curve morphology, period-luminosity relations, and position in the Petersen diagram. We present the most interesting individual objects in our collection: a typeII Cepheid with additional eclipsing modulation, WVir stars with the period doubling effect and the RVb phenomenon, a mode-switching RR Lyr star, and a triple-mode anomalous RRd star.

A Modulated-Gradient Parametrization for the Large-Eddy Simulation of the Atmospheric Boundary Layer Using the Weather Research and Forecasting Model

NASA Astrophysics Data System (ADS)

Khani, Sina; Porté-Agel, Fernando

2017-12-01

The performance of the modulated-gradient subgrid-scale (SGS) model is investigated using large-eddy simulation (LES) of the neutral atmospheric boundary layer within the weather research and forecasting model. Since the model includes a finite-difference scheme for spatial derivatives, the discretization errors may affect the simulation results. We focus here on understanding the effects of finite-difference schemes on the momentum balance and the mean velocity distribution, and the requirement (or not) of the ad hoc canopy model. We find that, unlike the Smagorinsky and turbulent kinetic energy (TKE) models, the calculated mean velocity and vertical shear using the modulated-gradient model, are in good agreement with Monin-Obukhov similarity theory, without the need for an extra near-wall canopy model. The structure of the near-wall turbulent eddies is better resolved using the modulated-gradient model in comparison with the classical Smagorinsky and TKE models, which are too dissipative and yield unrealistic smoothing of the smallest resolved scales. Moreover, the SGS fluxes obtained from the modulated-gradient model are much smaller near the wall in comparison with those obtained from the regular Smagorinsky and TKE models. The apparent inability of the LES model in reproducing the mean streamwise component of the momentum balance using the total (resolved plus SGS) stress near the surface is probably due to the effect of the discretization errors, which can be calculated a posteriori using the Taylor-series expansion of the resolved velocity field. Overall, we demonstrate that the modulated-gradient model is less dissipative and yields more accurate results in comparison with the classical Smagorinsky model, with similar computational costs.

Interplanetary Coronal Mass Ejections During 1996 - 2007

NASA Technical Reports Server (NTRS)

Richardson, I. G.; Cane, H. V.

2007-01-01

Interplanetary coronal mass ejections, the interplanetary counterparts of coronal mass ejections at the Sun, are the major drivers of interplanetary shocks in the heliosphere, and are associated with modulations of the galactic cosmic ray intensity, both short term (Forbush decreases caused by the passage of the shock, post-shock sheath, and ICME), and possibly with longer term modulation. Using several in-situ signatures of ICMEs, including plasma temperature, and composition, magnetic fields, and cosmic ray modulations, made by near-Earth spacecraft, we have compiled a "comprehensive" list of ICMEs passing the Earth since 1996, encompassing solar cycle 23. We summarize the properties of these ICMEs, such as their occurrence rate, speeds and other parameters, the fraction of ICMEs that are classic magnetic clouds, and their association with solar energetic particle events, halo CMEs, interplanetary shocks, geomagnetic storms, shocks and cosmic ray decreases.

Classical Optimal Control for Energy Minimization Based On Diffeomorphic Modulation under Observable-Response-Preserving Homotopy.

PubMed

Soley, Micheline B; Markmann, Andreas; Batista, Victor S

2018-06-12

We introduce the so-called "Classical Optimal Control Optimization" (COCO) method for global energy minimization based on the implementation of the diffeomorphic modulation under observable-response-preserving homotopy (DMORPH) gradient algorithm. A probe particle with time-dependent mass m( t;β) and dipole μ( r, t;β) is evolved classically on the potential energy surface V( r) coupled to an electric field E( t;β), as described by the time-dependent density of states represented on a grid, or otherwise as a linear combination of Gaussians generated by the k-means clustering algorithm. Control parameters β defining m( t;β), μ( r, t;β), and E( t;β) are optimized by following the gradients of the energy with respect to β, adapting them to steer the particle toward the global minimum energy configuration. We find that the resulting COCO algorithm is capable of resolving near-degenerate states separated by large energy barriers and successfully locates the global minima of golf potentials on flat and rugged surfaces, previously explored for testing quantum annealing methodologies and the quantum optimal control optimization (QuOCO) method. Preliminary results show successful energy minimization of multidimensional Lennard-Jones clusters. Beyond the analysis of energy minimization in the specific model systems investigated, we anticipate COCO should be valuable for solving minimization problems in general, including optimization of parameters in applications to machine learning and molecular structure determination.

The European Classical Swine Fever Virus Database: Blueprint for a Pathogen-Specific Sequence Database with Integrated Sequence Analysis Tools

PubMed Central

Postel, Alexander; Schmeiser, Stefanie; Zimmermann, Bernd; Becher, Paul

2016-01-01

Molecular epidemiology has become an indispensable tool in the diagnosis of diseases and in tracing the infection routes of pathogens. Due to advances in conventional sequencing and the development of high throughput technologies, the field of sequence determination is in the process of being revolutionized. Platforms for sharing sequence information and providing standardized tools for phylogenetic analyses are becoming increasingly important. The database (DB) of the European Union (EU) and World Organisation for Animal Health (OIE) Reference Laboratory for classical swine fever offers one of the world’s largest semi-public virus-specific sequence collections combined with a module for phylogenetic analysis. The classical swine fever (CSF) DB (CSF-DB) became a valuable tool for supporting diagnosis and epidemiological investigations of this highly contagious disease in pigs with high socio-economic impacts worldwide. The DB has been re-designed and now allows for the storage and analysis of traditionally used, well established genomic regions and of larger genomic regions including complete viral genomes. We present an application example for the analysis of highly similar viral sequences obtained in an endemic disease situation and introduce the new geographic “CSF Maps” tool. The concept of this standardized and easy-to-use DB with an integrated genetic typing module is suited to serve as a blueprint for similar platforms for other human or animal viruses. PMID:27827988

Solitons and ionospheric modification

NASA Technical Reports Server (NTRS)

Sheerin, J. P.; Nicholson, D. R.; Payne, G. L.; Hansen, P. J.; Weatherall, J. C.; Goldman, M. V.

1982-01-01

The possibility of Langmuir soliton formation and collapse during ionospheric modification is investigated. Parameters characterizing former facilities, existing facilities, and planned facilities are considered, using a combination of analytical and numerical techniques. At a spatial location corresponding to the exact classical reflection point of the modifier wave, the Langmuir wave evolution is found to be dominated by modulational instability followed by soliton formation and three-dimensional collapse. The earth's magnetic field is found to affect the shape of the collapsing soliton. These results provide an alternative explanation for some recent observations.

Modulation Doped GaAs/Al sub xGA sub (1-x)As Layered Structures with Applications to Field Effect Transistors.

DTIC Science & Technology

1982-02-15

function of the doping density at 300 and 77 K for the classical Boltzmann statistics or depletion approximation (solid line) and for the approximate...Fermi-Dirac statistics (equation (19) dotted line)• This comparison demonstrates that the deviation from Boltzmann statistics is quite noticeable...tunneling Schottky barriers cannot be obtained at these doping levels. The dotted lines are obtained when Boltzmann statistics are used in the Al Ga

The formal de Rham complex

NASA Astrophysics Data System (ADS)

Zharinov, V. V.

2013-02-01

We propose a formal construction generalizing the classic de Rham complex to a wide class of models in mathematical physics and analysis. The presentation is divided into a sequence of definitions and elementary, easily verified statements; proofs are therefore given only in the key case. Linear operations are everywhere performed over a fixed number field {F} = {R},{C}. All linear spaces, algebras, and modules, although not stipulated explicitly, are by definition or by construction endowed with natural locally convex topologies, and their morphisms are continuous.

Influence of homogeneous magnetic fields on the flow of a ferrofluid in the Taylor-Couette system.

PubMed

Altmeyer, S; Hoffmann, Ch; Leschhorn, A; Lücke, M

2010-07-01

We investigate numerically the influence of a homogeneous magnetic field on a ferrofluid in the gap between two concentric, independently rotating cylinders. The full Navier-Stokes equations are solved with a combination of a finite difference method and a Galerkin method. Structure, dynamics, symmetry properties, bifurcation, and stability behavior of different vortex structures are investigated for axial and transversal magnetic fields, as well as combinations of them. We show that a transversal magnetic field modulates the Taylor vortex flow and the spiral vortex flow. Thus, a transversal magnetic field induces wavy structures: wavy Taylor vortex flow (wTVF) and wavy spiral vortex flow. In contrast to the classic wTVF, which is a secondarily bifurcating structure, these magnetically generated wavy Taylor vortices are pinned by the magnetic field, i.e., they are stationary and they appear via a primary forward bifurcation out of the basic state of circular Couette flow.

Modulation of V1 Spike Response by Temporal Interval of Spatiotemporal Stimulus Sequence

PubMed Central

Kim, Taekjun; Kim, HyungGoo R.; Kim, Kayeon; Lee, Choongkil

2012-01-01

The spike activity of single neurons of the primary visual cortex (V1) becomes more selective and reliable in response to wide-field natural scenes compared to smaller stimuli confined to the classical receptive field (RF). However, it is largely unknown what aspects of natural scenes increase the selectivity of V1 neurons. One hypothesis is that modulation by surround interaction is highly sensitive to small changes in spatiotemporal aspects of RF surround. Such a fine-tuned modulation would enable single neurons to hold information about spatiotemporal sequences of oriented stimuli, which extends the role of V1 neurons as a simple spatiotemporal filter confined to the RF. In the current study, we examined the hypothesis in the V1 of awake behaving monkeys, by testing whether the spike response of single V1 neurons is modulated by temporal interval of spatiotemporal stimulus sequence encompassing inside and outside the RF. We used two identical Gabor stimuli that were sequentially presented with a variable stimulus onset asynchrony (SOA): the preceding one (S1) outside the RF and the following one (S2) in the RF. This stimulus configuration enabled us to examine the spatiotemporal selectivity of response modulation from a focal surround region. Although S1 alone did not evoke spike responses, visual response to S2 was modulated for SOA in the range of tens of milliseconds. These results suggest that V1 neurons participate in processing spatiotemporal sequences of oriented stimuli extending outside the RF. PMID:23091631

The research on thermal adaptability reinforcement technology for photovoltaic modules

NASA Astrophysics Data System (ADS)

Su, Nana; Zhou, Guozhong

2015-10-01

Nowadays, Photovoltaic module contains more high-performance components in smaller space. It is also demanded to work in severe temperature condition for special use, such as aerospace. As temperature rises, the failure rate will increase exponentially which makes reliability significantly reduce. In order to improve thermal adaptability of photovoltaic module, this paper makes a research on reinforcement technologies. Thermoelectric cooler is widely used in aerospace which has harsh working environment. So, theoretical formulas for computing refrigerating efficiency, refrigerating capacity and temperature difference are described in detail. The optimum operating current of three classical working condition is obtained which can be used to guide the design of driven circuit. Taken some equipment enclosure for example, we use thermoelectric cooler to reinforce its thermal adaptability. By building physical model and thermal model with the aid of physical dimension and constraint condition, the model is simulated by Flotherm. The temperature field cloud is shown to verify the effectiveness of reinforcement.

Differential operators on the supercircle S1|2 and symbol map

NASA Astrophysics Data System (ADS)

Hamza, Raouafi; Selmi, Zeineb; Boujelben, Jamel

2017-09-01

We consider the supercircle S1|2 equipped with the standard contact structure. The conformal Lie superalgebra 𝒦(2) acts on S1|2 as the Lie superalgebra of contact vector fields; it contains the Möbius superalgebra 𝔬𝔰𝔭(2|2). We study the space of linear differential operators on weighted densities as a module over 𝔬𝔰𝔭(2|2). We introduce the canonical isomorphism between this space and the corresponding space of symbols. This result allows us to give, in contrast to the classical setting, a classification of the 𝒦(2)-modules 𝔇λ,μk of linear differential operators of order k acting on the superspaces of weighted densities. This work is the simplest superization of a result by Gargoubi and Ovsienko [Modules of differential operators on the real line, Funct. Anal. Appl. 35(1) (2001) 13-18.

Mode-locking via dissipative Faraday instability

PubMed Central

Tarasov, Nikita; Perego, Auro M.; Churkin, Dmitry V.; Staliunas, Kestutis; Turitsyn, Sergei K.

2016-01-01

Emergence of coherent structures and patterns at the nonlinear stage of modulation instability of a uniform state is an inherent feature of many biological, physical and engineering systems. There are several well-studied classical modulation instabilities, such as Benjamin–Feir, Turing and Faraday instability, which play a critical role in the self-organization of energy and matter in non-equilibrium physical, chemical and biological systems. Here we experimentally demonstrate the dissipative Faraday instability induced by spatially periodic zig-zag modulation of a dissipative parameter of the system—spectrally dependent losses—achieving generation of temporal patterns and high-harmonic mode-locking in a fibre laser. We demonstrate features of this instability that distinguish it from both the Benjamin–Feir and the purely dispersive Faraday instability. Our results open the possibilities for new designs of mode-locked lasers and can be extended to other fields of physics and engineering. PMID:27503708

Mode-locking via dissipative Faraday instability.

PubMed

Tarasov, Nikita; Perego, Auro M; Churkin, Dmitry V; Staliunas, Kestutis; Turitsyn, Sergei K

2016-08-09

Emergence of coherent structures and patterns at the nonlinear stage of modulation instability of a uniform state is an inherent feature of many biological, physical and engineering systems. There are several well-studied classical modulation instabilities, such as Benjamin-Feir, Turing and Faraday instability, which play a critical role in the self-organization of energy and matter in non-equilibrium physical, chemical and biological systems. Here we experimentally demonstrate the dissipative Faraday instability induced by spatially periodic zig-zag modulation of a dissipative parameter of the system-spectrally dependent losses-achieving generation of temporal patterns and high-harmonic mode-locking in a fibre laser. We demonstrate features of this instability that distinguish it from both the Benjamin-Feir and the purely dispersive Faraday instability. Our results open the possibilities for new designs of mode-locked lasers and can be extended to other fields of physics and engineering.

Stability of spanwise-modulated flows behind backward-facing steps

NASA Astrophysics Data System (ADS)

Boiko, A. V.; Dovgal, A. V.; Sorokin, A. M.

2017-10-01

An overview and synthesis of researches on development of local vortical disturbances in laminar separated flows downstream of backward-facing steps, in which the velocity field depends essentially on two variables are given. Peculiarities of transition to turbulence in such spatially inhomogeneous separated zones are discussed. The experimental data are supplemented by the linear stability characteristics of model velocity profiles of the separated flow computed using both the classical local formulation and the nonlocal approach based on the Floquet theory for partial differential equations with periodic coefficients. The results clarify the response of the local separated flows to their modulation with stationary geometrical and temperature inhomogeneities. The results can be useful for the development of new methods of laminar separation control.

Stix Award: The ponderomotive effect beyond the ponderomotive force

NASA Astrophysics Data System (ADS)

Dodin, I. Y.

2014-10-01

The classical ponderomotive effect (PE) is typically understood as the nonlinear time-average force produced by a rapidly oscillating electromagnetic field on a nonresonant particle. It is instructive to contrast this understanding with the common quantum interpretation of the PE as the ac Stark shift, i.e., phase modulation, or a Kerr effect experienced by the wave function. Then the PE is naturally extended from particles to waves and can be calculated efficiently in general settings, including for strongly nonlinear interactions and resonant dynamics. In particular, photons (plasmons, etc.) are hence seen to have polarizability and contribute to the linear dielectric tensor exactly like ``true'' particles such as electrons and ions. The talk will briefly review the underlying variational theory and some nonintuitive PE-based techniques of wave and particle manipulation that the theory predicts. It will also be shown that the PE can be understood as the cause for the basic properties of both linear and nonlinear waves in plasma, including their dispersion, energy-momentum transport, and various modulational instabilities. Linear collisionless dissipation (both on particles and classical waves, treated on the same footing) also appears merely as a special case of the modulational dynamics. The work was supported by NNSA grant DE274-FG52-08NA28553, DOE contract DE-AC02-09CH11466, and DTRA grant HDTRA1-11-1-0037.

Effect of the incidence angle to free space optical communication based on cat-eye modulating retro-reflector

NASA Astrophysics Data System (ADS)

Zhang, Lai-xian; Sun, Hua-yan; Zhao, Yan-zhong; Zheng, Yong-hui; Shan, Cong-miao

2013-08-01

Based on the cat-eye effect of optical system, free space optical communication based on cat-eye modulating retro-reflector can build communication link rapidly. Compared to classical free space optical communication system, system based on cat-eye modulating retro-reflector has great advantages such as building communication link more rapidly, a passive terminal is smaller, lighter and lower power consuming. The incident angle is an important factor of cat-eye effect, so it will affect the retro-reflecting communication link. In this paper, the principle and work flow of free space optical communication based on cat-eye modulating retro-reflector were introduced. Then, using the theory of geometric optics, the equivalent model of modulating retro-reflector with incidence angle was presented. The analytical solution of active area and retro-reflected light intensity of cat-eye modulating retro-reflector were given. Noise of PIN photodetector was analyzed, based on which, bit error rate of free space optical communication based on cat-eye modulating retro-reflector was presented. Finally, simulations were done to study the effect of incidence angle to the communication. The simulation results show that the incidence angle has little effect on active area and retro-reflected light intensity when the incidence beam is in the active field angle of cat-eye modulating retro-reflector. With certain system and condition, the communication link can rapidly be built when the incidence light beam is in the field angle, and the bit error rate increases greatly with link range. When link range is smaller than 35Km, the bit error rate is less than 10-16.

Solar-cell interconnect design for terrestrial photovoltaic modules

NASA Technical Reports Server (NTRS)

Mon, G. R.; Moore, D. M.; Ross, R. G., Jr.

1984-01-01

Useful solar cell interconnect reliability design and life prediction algorithms are presented, together with experimental data indicating that the classical strain cycle (fatigue) curve for the interconnect material does not account for the statistical scatter that is required in reliability predictions. This shortcoming is presently addressed by fitting a functional form to experimental cumulative interconnect failure rate data, which thereby yields statistical fatigue curves enabling not only the prediction of cumulative interconnect failures during the design life of an array field, but also the quantitative interpretation of data from accelerated thermal cycling tests. Optimal interconnect cost reliability design algorithms are also derived which may allow the minimization of energy cost over the design life of the array field.

Solar-cell interconnect design for terrestrial photovoltaic modules

NASA Astrophysics Data System (ADS)

Mon, G. R.; Moore, D. M.; Ross, R. G., Jr.

1984-11-01

Useful solar cell interconnect reliability design and life prediction algorithms are presented, together with experimental data indicating that the classical strain cycle (fatigue) curve for the interconnect material does not account for the statistical scatter that is required in reliability predictions. This shortcoming is presently addressed by fitting a functional form to experimental cumulative interconnect failure rate data, which thereby yields statistical fatigue curves enabling not only the prediction of cumulative interconnect failures during the design life of an array field, but also the quantitative interpretation of data from accelerated thermal cycling tests. Optimal interconnect cost reliability design algorithms are also derived which may allow the minimization of energy cost over the design life of the array field.

Correlations in V1 are reduced by stimulation outside the receptive field.

PubMed

Snyder, Adam C; Morais, Michael J; Kohn, Adam; Smith, Matthew A

2014-08-20

The trial-to-trial response variability of nearby cortical neurons is correlated. These correlations may strongly influence population coding performance. Numerous studies have shown that correlations can be dynamically modified by attention, adaptation, learning, and potent stimulus drive. However, the mechanisms that influence correlation strength remain poorly understood. Here we test whether correlations are influenced by presenting stimuli outside the classical receptive field (RF) of visual neurons, where they recruit a normalization signal termed surround suppression. We recorded simultaneously the activity of dozens of cells using microelectrode arrays implanted in the superficial layers of V1 in anesthetized, paralyzed macaque monkeys. We presented annular stimuli that encircled--but did not impinge upon--the RFs of the recorded cells. We found that these "extra-classical" stimuli reduced correlations in the absence of stimulation of the RF, closely resembling the decorrelating effects of stimulating the RFs directly. Our results suggest that normalization signals may be an important mechanism for modulating correlations. Copyright © 2014 the authors 0270-6474/14/3411222-06$15.00/0.

Agile wide-angle beam steering with electrowetting microprisms

NASA Astrophysics Data System (ADS)

Smith, Neil R.; Abeysinghe, Don C.; Haus, Joseph W.; Heikenfeld, Jason

2006-07-01

A novel basis for beam steering with electrowetting microprisms (EMPs) is reported. EMPs utilize electrowetting modulation of liquid contact angle in order to mimic the refractive behavior for various classical prism geometries. Continuous beam steering through an angle of 14° (±7°) has been demonstrated with a liquid index of n=1.359. Experimental results are well-matched to theoretical behavior up to the point of electrowetting contact-angle saturation. Projections show that use of higher index liquids (n~1.6) will result in steering through ~30° (±15°). Fundamental factors defining achievable deflection range, and issues for Ladar use, are reviewed. This approach is capable of good switching speed (~ms), polarization independent operation, modulation of beam field-of-view (lensing), and high steering efficiency that is independent of deflection angle.

Habitable Moons and Planets Around Post-Main Sequence Stars

NASA Astrophysics Data System (ADS)

Lorenz, R.

2014-04-01

Habitability is ephemeral, and arises against the backdrop of stellar evolution. Atmospheric modulation of incoming and outgoing radiative fluxes can restrict or extend the insolation domain in which habitable conditions can persist, and feedbacks (notably, silicate weathering of CO2) may fortuitously adapt that modulation to counteract evolving luminosity. But eventually the star will win. What happens then depends on the histories of stellar luminosity, and of stellar mass loss. While the enhancement of luminosity may render the outer solar system habitable in a classic radiative/convective equilibrium sense, a scenario studied in most detail in connection with Saturn's moon Titan, the enhanced solar wind associated with the latter may strip atmospheres unprotected by magnetic fields. The question of post-main sequence habitability is therefore not a simple one.

A multi-modal stereo microscope based on a spatial light modulator.

PubMed

Lee, M P; Gibson, G M; Bowman, R; Bernet, S; Ritsch-Marte, M; Phillips, D B; Padgett, M J

2013-07-15

Spatial Light Modulators (SLMs) can emulate the classic microscopy techniques, including differential interference (DIC) contrast and (spiral) phase contrast. Their programmability entails the benefit of flexibility or the option to multiplex images, for single-shot quantitative imaging or for simultaneous multi-plane imaging (depth-of-field multiplexing). We report the development of a microscope sharing many of the previously demonstrated capabilities, within a holographic implementation of a stereo microscope. Furthermore, we use the SLM to combine stereo microscopy with a refocusing filter and with a darkfield filter. The instrument is built around a custom inverted microscope and equipped with an SLM which gives various imaging modes laterally displaced on the same camera chip. In addition, there is a wide angle camera for visualisation of a larger region of the sample.

Design and application of 3D-printed stepless beam modulators in proton therapy

NASA Astrophysics Data System (ADS)

Lindsay, C.; Kumlin, J.; Martinez, D. M.; Jirasek, A.; Hoehr, C.

2016-06-01

A new method for the design of stepless beam modulators for proton therapy is described and verified. Simulations of the classic designs are compared against the stepless method for various modulation widths which are clinically applicable in proton eye therapy. Three modulator wheels were printed using a Stratasys Objet30 3D printer. The resulting depth dose distributions showed improved uniformity over the classic stepped designs. Simulated results imply a possible improvement in distal penumbra width; however, more accurate measurements are needed to fully verify this effect. Lastly, simulations were done to model bio-equivalence to Co-60 cell kill. A wheel was successfully designed to flatten this metric.

Controlling chaos-assisted directed transport via quantum resonance.

PubMed

Tan, Jintao; Zou, Mingliang; Luo, Yunrong; Hai, Wenhua

2016-06-01

We report on the first demonstration of chaos-assisted directed transport of a quantum particle held in an amplitude-modulated and tilted optical lattice, through a resonance-induced double-mean displacement relating to the true classically chaotic orbits. The transport velocity is controlled by the driving amplitude and the sign of tilt, and also depends on the phase of the initial state. The chaos-assisted transport feature can be verified experimentally by using a source of single atoms to detect the double-mean displacement one by one, and can be extended to different scientific fields.

Quantum memory for Rindler supertranslations

NASA Astrophysics Data System (ADS)

Kolekar, Sanved; Louko, Jorma

2018-04-01

The Rindler horizon in Minkowski spacetime can be implanted with supertranslation hair by a matter shock wave without planar symmetry, and the hair is observable as a supertranslation memory on the Rindler family of uniformly linearly accelerated observers. We show that this classical memory is accompanied by a supertranslation quantum memory that modulates the entanglement between the opposing Rindler wedges in quantum field theory. A corresponding phenomenon across a black hole horizon may play a role in Hawking, Perry, and Strominger's proposal for supertranslations to provide a solution to the black hole information paradox.

Controlling chaos-assisted directed transport via quantum resonance

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tan, Jintao; Zou, Mingliang; Luo, Yunrong

2016-06-15

We report on the first demonstration of chaos-assisted directed transport of a quantum particle held in an amplitude-modulated and tilted optical lattice, through a resonance-induced double-mean displacement relating to the true classically chaotic orbits. The transport velocity is controlled by the driving amplitude and the sign of tilt, and also depends on the phase of the initial state. The chaos-assisted transport feature can be verified experimentally by using a source of single atoms to detect the double-mean displacement one by one, and can be extended to different scientific fields.

Diagrammar in classical scalar field theory

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cattaruzza, E., E-mail: Enrico.Cattaruzza@gmail.com; Gozzi, E., E-mail: gozzi@ts.infn.it; INFN, Sezione di Trieste

2011-09-15

In this paper we analyze perturbatively a g{phi}{sup 4}classical field theory with and without temperature. In order to do that, we make use of a path-integral approach developed some time ago for classical theories. It turns out that the diagrams appearing at the classical level are many more than at the quantum level due to the presence of extra auxiliary fields in the classical formalism. We shall show that a universal supersymmetry present in the classical path-integral mentioned above is responsible for the cancelation of various diagrams. The same supersymmetry allows the introduction of super-fields and super-diagrams which considerably simplifymore » the calculations and make the classical perturbative calculations almost 'identical' formally to the quantum ones. Using the super-diagrams technique, we develop the classical perturbation theory up to third order. We conclude the paper with a perturbative check of the fluctuation-dissipation theorem. - Highlights: > We provide the Feynman diagrams of perturbation theory for a classical field theory. > We give a super-formalism which links the quantum diagrams to the classical ones. > We check perturbatively the fluctuation-dissipation theorem.« less

Ionospheric very low frequency transmitter

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kuo, Spencer P.

2015-02-15

The theme of this paper is to establish a reliable ionospheric very low frequency (VLF) transmitter, which is also broad band. Two approaches are studied that generate VLF waves in the ionosphere. The first, classic approach employs a ground-based HF heater to directly modulate the high latitude ionospheric, or auroral electrojet. In the classic approach, the intensity-modulated HF heater induces an alternating current in the electrojet, which serves as a virtual antenna to transmit VLF waves. The spatial and temporal variations of the electrojet impact the reliability of the classic approach. The second, beat-wave approach also employs a ground-based HFmore » heater; however, in this approach, the heater operates in a continuous wave mode at two HF frequencies separated by the desired VLF frequency. Theories for both approaches are formulated, calculations performed with numerical model simulations, and the calculations are compared to experimental results. Theory for the classic approach shows that an HF heater wave, intensity-modulated at VLF, modulates the electron temperature dependent electrical conductivity of the ionospheric electrojet, which, in turn, induces an ac electrojet current. Thus, the electrojet becomes a virtual VLF antenna. The numerical results show that the radiation intensity of the modulated electrojet decreases with an increase in VLF radiation frequency. Theory for the beat wave approach shows that the VLF radiation intensity depends upon the HF heater intensity rather than the electrojet strength, and yet this approach can also modulate the electrojet when present. HF heater experiments were conducted for both the intensity modulated and beat wave approaches. VLF radiations were generated and the experimental results confirm the numerical simulations. Theory and experimental results both show that in the absence of the electrojet, VLF radiation from the F-region is generated via the beat wave approach. Additionally, the beat wave approach generates VLF radiations over a larger frequency band than by the modulated electrojet.« less

Gamma-band activation predicts both associative memory and cortical plasticity

PubMed Central

Headley, Drew B.; Weinberger, Norman M.

2011-01-01

Gamma-band oscillations are a ubiquitous phenomenon in the nervous system and have been implicated in multiple aspects of cognition. In particular, the strength of gamma oscillations at the time a stimulus is encoded predicts its subsequent retrieval, suggesting that gamma may reflect enhanced mnemonic processing. Likewise, activity in the gamma-band can modulate plasticity in vitro. However, it is unclear whether experience-dependent plasticity in vivo is also related to gamma-band activation. The aim of the present study is to determine whether gamma activation in primary auditory cortex modulates both the associative memory for an auditory stimulus during classical conditioning and its accompanying specific receptive field plasticity. Rats received multiple daily sessions of single tone/shock trace and two-tone discrimination conditioning, during which local field potentials and multiunit discharges were recorded from chronically implanted electrodes. We found that the strength of tone-induced gamma predicted the acquisition of associative memory 24 h later, and ceased to predict subsequent performance once asymptote was reached. Gamma activation also predicted receptive field plasticity that specifically enhanced representation of the signal tone. This concordance provides a long-sought link between gamma oscillations, cortical plasticity and the formation of new memories. PMID:21900554

Atomic photoionization processes under magnification

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lepine, F.; Bordas, Ch.; Nicole, C.

2004-09-01

Recently, classical simulations of threshold photoionization in the presence of an electric field have shown that a clear distinction between direct and indirect trajectories followed by the outgoing electron can be observed in the patterns of electron impacts on a two-dimensional detector. Subsequently, slow photoelectron imaging experiments have been reported where this distinction could be observed in atomic xenon. Furthermore, using a magnifying electrostatic lens to improve the velocity-map imaging technique, oscillatory patterns were observed modulating the classical envelope that was measured in the experiments of Nicole et al. [Phys. Rev. Lett. 88, 133001 (2002)]. This extension of slow photoelectronmore » imaging, called photoionization microscopy, relies on the existence of interferences between various trajectories by which the electron moves from the atom to the plane of observation. In this article we present the main experimental results obtained both in slow photoelectron imaging and in photoionization microscopy. The formation of the interference pattern is discussed in the framework of a semiclassical model that is described in detail elsewhere. The qualitative information that can be drawn from the experiments is discussed, and the potential applications of photoionization microscopy are considered. Particular attention is paid to the role of continuum Stark resonances that appear between the saddle point in the Coulomb+dc field potential and the field-free ionization limit.« less

Glycemic modulation in neuro-oncology: experience and future directions using a modified Atkins diet for high-grade brain tumors

PubMed Central

Strowd, Roy E.; Cervenka, Mackenzie C.; Henry, Bobbie J.; Kossoff, Eric H.; Hartman, Adam L.; Blakeley, Jaishri O.

2015-01-01

Dietary glycemic modulation through high-fat, low-carbohydrate diets, which induce a state of systemic ketosis and alter systemic metabolic signaling, have been incorporated into the clinical management of patients with neurological disease for more than a century. Mounting preclinical evidence supports the antitumor, proapoptotic, and antiangiogenic effects of disrupting glycolytic metabolism through dietary intervention. In recent years, interest in incorporating such novel therapeutic strategies in neuro-oncology has increased. To date, 3 published studies incorporating novel dietary therapies in oncology have been reported, including one phase I study in neuro-oncology, and have set the stage for further study in this field. In this article, we review the biochemical pathways, preclinical data, and early clinical translation of dietary interventions that modulate systemic glycolytic metabolism in the management of primary malignant brain tumors. We introduce the modified Atkins diet (MAD), a novel dietary alternative to the classic ketogenic diet, and discuss the critical issues facing future study. PMID:26649186

Ladder Climbing and Autoresonant Acceleration of Plasma Waves

NASA Astrophysics Data System (ADS)

Barth, Ido; Dodin, Ilya; Fisch, Nathaniel

2015-11-01

When the background density in a bounded plasma is modulated in time, discrete modes become coupled. Interestingly, for appropriately chosen modulations, the average plasmon energy might be made to grow in a ladder-like manner, achieving up-conversion or down-conversion of the plasmon energy. This reversible process is identified as a classical analog of the effect known as quantum ladder climbing, so that the efficiency and the rate of this process can be written immediately by analogy to a quantum particle in a box. In the limit of densely spaced spectrum, ladder climbing transforms into continuous autoresonance; plasmons may then be manipulated by chirped background modulations much like electrons are autoresonantly manipulated by chirped fields. By formulating the wave dynamics within a universal Lagrangian framework, similar ladder climbing and autoresonance effects are predicted to be achievable with general linear waves in both plasma and other media. Supported by NNSA grant DE274-FG52-08NA28553, DOE contract DE-AC02-09CH11466, and DTRA grant HDTRA1-11-1-0037.

Runge-Lenz wave packet in multichannel Stark photoionization

DOE Office of Scientific and Technical Information (OSTI.GOV)

Texier, F.

2005-01-01

In a previous slow photoionization experiment, modulations of ionization rings were manifested for Xe in a constant electric field. The present quantum calculation reveals that the modulation is an effect of the multichannel core scattering and of tunneling waves through the Coulomb-Stark potential barrier: the barrier reduces the number of oscillations that is observed relatively to the number of oscillations of the short range wave functions, and the nonhydrogenic core phase shifts modify the position of the ionization rings. We find a hidden difference, in the ionization process, for two close values of the energy depending on the resonance withmore » the barrier. The ionization intensity is interpreted as a Runge-Lenz wave packet; thus, we can relate the quantum modulation to the classical Coulomb-Stark trajectories. The Runge-Lenz wave packet differs from a usual temporal wave packet because its components are eigenstates of the Runge-Lenz vector z projection and its evolution is not temporal but spatial.« less

Synthetic biology: new engineering rules for an emerging discipline

PubMed Central

Andrianantoandro, Ernesto; Basu, Subhayu; Karig, David K; Weiss, Ron

2006-01-01

Synthetic biologists engineer complex artificial biological systems to investigate natural biological phenomena and for a variety of applications. We outline the basic features of synthetic biology as a new engineering discipline, covering examples from the latest literature and reflecting on the features that make it unique among all other existing engineering fields. We discuss methods for designing and constructing engineered cells with novel functions in a framework of an abstract hierarchy of biological devices, modules, cells, and multicellular systems. The classical engineering strategies of standardization, decoupling, and abstraction will have to be extended to take into account the inherent characteristics of biological devices and modules. To achieve predictability and reliability, strategies for engineering biology must include the notion of cellular context in the functional definition of devices and modules, use rational redesign and directed evolution for system optimization, and focus on accomplishing tasks using cell populations rather than individual cells. The discussion brings to light issues at the heart of designing complex living systems and provides a trajectory for future development. PMID:16738572

Synthetic biology: new engineering rules for an emerging discipline.

PubMed

Andrianantoandro, Ernesto; Basu, Subhayu; Karig, David K; Weiss, Ron

2006-01-01

Synthetic biologists engineer complex artificial biological systems to investigate natural biological phenomena and for a variety of applications. We outline the basic features of synthetic biology as a new engineering discipline, covering examples from the latest literature and reflecting on the features that make it unique among all other existing engineering fields. We discuss methods for designing and constructing engineered cells with novel functions in a framework of an abstract hierarchy of biological devices, modules, cells, and multicellular systems. The classical engineering strategies of standardization, decoupling, and abstraction will have to be extended to take into account the inherent characteristics of biological devices and modules. To achieve predictability and reliability, strategies for engineering biology must include the notion of cellular context in the functional definition of devices and modules, use rational redesign and directed evolution for system optimization, and focus on accomplishing tasks using cell populations rather than individual cells. The discussion brings to light issues at the heart of designing complex living systems and provides a trajectory for future development.

Classical Field Theory and the Stress-Energy Tensor

NASA Astrophysics Data System (ADS)

Swanson, Mark S.

2015-09-01

This book is a concise introduction to the key concepts of classical field theory for beginning graduate students and advanced undergraduate students who wish to study the unifying structures and physical insights provided by classical field theory without dealing with the additional complication of quantization. In that regard, there are many important aspects of field theory that can be understood without quantizing the fields. These include the action formulation, Galilean and relativistic invariance, traveling and standing waves, spin angular momentum, gauge invariance, subsidiary conditions, fluctuations, spinor and vector fields, conservation laws and symmetries, and the Higgs mechanism, all of which are often treated briefly in a course on quantum field theory. The variational form of classical mechanics and continuum field theory are both developed in the time-honored graduate level text by Goldstein et al (2001). An introduction to classical field theory from a somewhat different perspective is available in Soper (2008). Basic classical field theory is often treated in books on quantum field theory. Two excellent texts where this is done are Greiner and Reinhardt (1996) and Peskin and Schroeder (1995). Green's function techniques are presented in Arfken et al (2013).

Salient contour extraction from complex natural scene in night vision image

NASA Astrophysics Data System (ADS)

Han, Jing; Yue, Jiang; Zhang, Yi; Bai, Lian-fa

2014-03-01

The theory of center-surround interaction in non-classical receptive field can be applied in night vision information processing. In this work, an optimized compound receptive field modulation method is proposed to extract salient contour from complex natural scene in low-light-level (LLL) and infrared images. The kernel idea is that multi-feature analysis can recognize the inhomogeneity in modulatory coverage more accurately and that center and surround with the grouping structure satisfying Gestalt rule deserves high connection-probability. Computationally, a multi-feature contrast weighted inhibition model is presented to suppress background and lower mutual inhibition among contour elements; a fuzzy connection facilitation model is proposed to achieve the enhancement of contour response, the connection of discontinuous contour and the further elimination of randomly distributed noise and texture; a multi-scale iterative attention method is designed to accomplish dynamic modulation process and extract contours of targets in multi-size. This work provides a series of biologically motivated computational visual models with high-performance for contour detection from cluttered scene in night vision images.

k-Cosymplectic Classical Field Theories: Tulczyjew and Skinner-Rusk Formulations

NASA Astrophysics Data System (ADS)

Rey, Angel M.; Román-Roy, Narciso; Salgado, Modesto; Vilariño, Silvia

2012-06-01

The k-cosymplectic Lagrangian and Hamiltonian formalisms of first-order classical field theories are reviewed and completed. In particular, they are stated for singular and almost-regular systems. Subsequently, several alternative formulations for k-cosymplectic first-order field theories are developed: First, generalizing the construction of Tulczyjew for mechanics, we give a new interpretation of the classical field equations. Second, the Lagrangian and Hamiltonian formalisms are unified by giving an extension of the Skinner-Rusk formulation on classical mechanics.

Temporal variability of spectro-temporal receptive fields in the anesthetized auditory cortex.

PubMed

Meyer, Arne F; Diepenbrock, Jan-Philipp; Ohl, Frank W; Anemüller, Jörn

2014-01-01

Temporal variability of neuronal response characteristics during sensory stimulation is a ubiquitous phenomenon that may reflect processes such as stimulus-driven adaptation, top-down modulation or spontaneous fluctuations. It poses a challenge to functional characterization methods such as the receptive field, since these often assume stationarity. We propose a novel method for estimation of sensory neurons' receptive fields that extends the classic static linear receptive field model to the time-varying case. Here, the long-term estimate of the static receptive field serves as the mean of a probabilistic prior distribution from which the short-term temporally localized receptive field may deviate stochastically with time-varying standard deviation. The derived corresponding generalized linear model permits robust characterization of temporal variability in receptive field structure also for highly non-Gaussian stimulus ensembles. We computed and analyzed short-term auditory spectro-temporal receptive field (STRF) estimates with characteristic temporal resolution 5-30 s based on model simulations and responses from in total 60 single-unit recordings in anesthetized Mongolian gerbil auditory midbrain and cortex. Stimulation was performed with short (100 ms) overlapping frequency-modulated tones. Results demonstrate identification of time-varying STRFs, with obtained predictive model likelihoods exceeding those from baseline static STRF estimation. Quantitative characterization of STRF variability reveals a higher degree thereof in auditory cortex compared to midbrain. Cluster analysis indicates that significant deviations from the long-term static STRF are brief, but reliably estimated. We hypothesize that the observed variability more likely reflects spontaneous or state-dependent internal fluctuations that interact with stimulus-induced processing, rather than experimental or stimulus design.

Exact treatment of the Jaynes-Cummings model under the action of an external classical field

DOE Office of Scientific and Technical Information (OSTI.GOV)

Abdalla, M. Sebawe, E-mail: m.sebaweh@physics.org; Khalil, E.M.; Mathematics Department, College of Science, Taibah University, Al-MaDinah

2011-09-15

We consider the usual Jaynes-Cummings model (JCM), in the presence of an external classical field. Under a certain canonical transformation for the Pauli operators, the system is transformed into the usual JCM. Using the equations of motion in the Heisenberg picture, exact solutions for the time-dependent dynamical operators are obtained. In order to calculate the expectation values of these operators, the wave function has been constructed. It has been shown that the classical field augments the atomic frequency {omega}{sub 0} and mixes the original atomic states. Changes of squeezing from one quadrature to another is also observed for a strongmore » value of the coupling parameter of the classical field. Furthermore, the system in this case displays partial entanglement and the state of the field losses its purity. - Highlights: > The time-dependent JCM, in the presence of the classical field, is still one of the essential problems in the quantum optics. > A new approach is applied through a certain canonical transformation. > The classical field augments the atomic frequency {omega}{sub 0} and mixes the original atomic states.« less

Continuous time quantum random walks in free space

NASA Astrophysics Data System (ADS)

Eichelkraut, Toni; Vetter, Christian; Perez-Leija, Armando; Christodoulides, Demetrios; Szameit, Alexander

2014-05-01

We show theoretically and experimentally that two-dimensional continuous time coherent random walks are possible in free space, that is, in the absence of any external potential, by properly tailoring the associated initial wave function. These effects are experimentally demonstrated using classical paraxial light. Evidently, the usage of classical beams to explore the dynamics of point-like quantum particles is possible since both phenomena are mathematically equivalent. This in turn makes our approach suitable for the realization of random walks using different quantum particles, including electrons and photons. To study the spatial evolution of a wavefunction theoretically, we consider the one-dimensional paraxial wave equation (i∂z +1/2 ∂x2) Ψ = 0 . Starting with the initially localized wavefunction Ψ (x , 0) = exp [ -x2 / 2σ2 ] J0 (αx) , one can show that the evolution of such Gaussian-apodized Bessel envelopes within a region of validity resembles the probability pattern of a quantum walker traversing a uniform lattice. In order to generate the desired input-field in our experimental setting we shape the amplitude and phase of a collimated light beam originating from a classical HeNe-Laser (633 nm) utilizing a spatial light modulator.

Exploiting evanescent-wave amplification for subwavelength low-contrast particle detection

NASA Astrophysics Data System (ADS)

Roy, S.; Pereira, S. F.; Urbach, H. P.; Wei, Xukang; El Gawhary, O.

2017-07-01

The classical problem of subwavelength particle detection on a flat surface is especially challenging when the refractive index of the particle is close to that of the substrate. We demonstrate a method to improve the detection ability several times for such a situation, by enhancing the "forbidden" evanescent waves in the substrate using the principle of super-resolution with evanescent waves amplification. The working mechanism of the system and experimental validation from a design with a thin single dielectric layer is presented. The resulting system is a simple but complete example of evanescent-wave generation, amplification, and the consequent modulation of the far field. This principle can have far reaching impact in the field of particle detection in several applications ranging from contamination control to interferometric scattering microscopy for biological samples.

A Lorentz model for weak magnetic field bioeffects: part I--thermal noise is an essential component of AC/DC effects on bound ion trajectory.

PubMed

Muehsam, David J; Pilla, Arthur A

2009-09-01

We have previously employed the Lorentz-Langevin model to describe the effects of weak exogenous magnetic fields via the classical Lorentz force on a charged ion bound in a harmonic oscillator potential, in the presence of thermal noise forces. Previous analyses predicted that microT-range fields give rise to a rotation of the oscillator orientation at the Larmor frequency and bioeffects were based upon the assumption that the classical trajectory of the bound charge itself could modulate a biochemical process. Here, it is shown that the thermal component of the motion follows the Larmor trajectory. The results show that the Larmor frequency is independent of the thermal noise strength, and the motion retains the form of a coherent oscillator throughout the binding lifetime, rather than devolving into a random walk. Thermal equilibration results in a continual increase in the vibrational amplitude of the rotating oscillator towards the steady-state amplitude, but does not affect the Larmor orbit. Thus, thermal noise contributes to, rather than inhibits, the effect of the magnetic field upon reactivity. Expressions are derived for the ensemble average of position and the velocity of the thermal component of the oscillator motion. The projection of position and velocity onto a Cartesian axis measures the nonuniformity of the Larmor trajectory and is illustrated for AC and combined AC/DC magnetic fields, suggesting a means of interpreting resonance phenomena. It is noted that the specific location and height of resonances are dependent upon binding lifetime and initial AC phase.

Functional characterization of the extraclassical receptive field in macaque V1: contrast, orientation, and temporal dynamics.

PubMed

Henry, Christopher A; Joshi, Siddhartha; Xing, Dajun; Shapley, Robert M; Hawken, Michael J

2013-04-03

Neurons in primary visual cortex, V1, very often have extraclassical receptive fields (eCRFs). The eCRF is defined as the region of visual space where stimuli cannot elicit a spiking response but can modulate the response of a stimulus in the classical receptive field (CRF). We investigated the dependence of the eCRF on stimulus contrast and orientation in macaque V1 cells for which the laminar location was determined. The eCRF was more sensitive to contrast than the CRF across the whole population of V1 cells with the greatest contrast differential in layer 2/3. We confirmed that many V1 cells experience stronger suppression for collinear than orthogonal stimuli in the eCRF. Laminar analysis revealed that the predominant bias for collinear suppression was found in layers 2/3 and 4b. The laminar pattern of contrast and orientation dependence suggests that eCRF suppression may derive from different neural circuits in different layers, and may be comprised of two distinct components: orientation-tuned and untuned suppression. On average tuned suppression was delayed by ∼25 ms compared with the onset of untuned suppression. Therefore, response modulation by the eCRF develops dynamically and rapidly in time.

Huangqin-Tang and Ingredients in Modulating the Pathogenesis of Ulcerative Colitis.

PubMed

Wang, Chunyan; Tang, Xudong; Zhang, Li

2017-01-01

Ulcerative colitis (UC) is the most common inflammatory bowel disease worldwide. Current therapies in UC cause limitations, and herb medicine provides an important choice for UC treatment. Huangqin-Tang (HQT) is a well-known classical traditional Chinese herbal formula and has been used in China for thousands of years. A large number of pharmacological studies demonstrated HQT and its ingredients to be effective in treating UC. Though the therapeutic effect has been evaluated, comprehensive up-to-date reviews in this field are not yet available. Here we aim to review our current understanding of HQT and its ingredients in treating UC and how the agents modulate the main pathogenesis of the disease, including the intestinal environment, immune imbalance, inflammatory pathways, and oxidative stress. The summary on this issue may provide better understanding of HQT and its ingredients in treating UC and possibly help in promoting its clinical application.

Classics. Essay on Teaching Able Students.

ERIC Educational Resources Information Center

Coffin, David D.

In a field as varied and as technical as the classical languages, the professional training of the teacher is of paramount importance. An undergraduate major and graduate school work in the field of classical languages give a general view of the field and show which writings are interesting or important and how difficult they are. A graduate…

Structural basis for modulation of a G-protein-coupled receptor by allosteric drugs

NASA Astrophysics Data System (ADS)

Dror, Ron O.; Green, Hillary F.; Valant, Celine; Borhani, David W.; Valcourt, James R.; Pan, Albert C.; Arlow, Daniel H.; Canals, Meritxell; Lane, J. Robert; Rahmani, Raphaël; Baell, Jonathan B.; Sexton, Patrick M.; Christopoulos, Arthur; Shaw, David E.

2013-11-01

The design of G-protein-coupled receptor (GPCR) allosteric modulators, an active area of modern pharmaceutical research, has proved challenging because neither the binding modes nor the molecular mechanisms of such drugs are known. Here we determine binding sites, bound conformations and specific drug-receptor interactions for several allosteric modulators of the M2 muscarinic acetylcholine receptor (M2 receptor), a prototypical family A GPCR, using atomic-level simulations in which the modulators spontaneously associate with the receptor. Despite substantial structural diversity, all modulators form cation-π interactions with clusters of aromatic residues in the receptor extracellular vestibule, approximately 15Å from the classical, `orthosteric' ligand-binding site. We validate the observed modulator binding modes through radioligand binding experiments on receptor mutants designed, on the basis of our simulations, either to increase or to decrease modulator affinity. Simulations also revealed mechanisms that contribute to positive and negative allosteric modulation of classical ligand binding, including coupled conformational changes of the two binding sites and electrostatic interactions between ligands in these sites. These observations enabled the design of chemical modifications that substantially alter a modulator's allosteric effects. Our findings thus provide a structural basis for the rational design of allosteric modulators targeting muscarinic and possibly other GPCRs.

Attention to pain! A neurocognitive perspective on attentional modulation of pain in neuroimaging studies.

PubMed

Torta, D M; Legrain, V; Mouraux, A; Valentini, E

2017-04-01

Several studies have used neuroimaging techniques to investigate brain correlates of the attentional modulation of pain. Although these studies have advanced the knowledge in the field, important confounding factors such as imprecise theoretical definitions of attention, incomplete operationalization of the construct under exam, and limitations of techniques relying on measuring regional changes in cerebral blood flow have hampered the potential relevance of the conclusions. Here, we first provide an overview of the major theories of attention and of attention in the study of pain to bridge theory and experimental results. We conclude that load and motivational/affective theories are particularly relevant to study the attentional modulation of pain and should be carefully integrated in functional neuroimaging studies. Then, we summarize previous findings and discuss the possible neural correlates of the attentional modulation of pain. We discuss whether classical functional neuroimaging techniques are suitable to measure the effect of a fluctuating process like attention, and in which circumstances functional neuroimaging can be reliably used to measure the attentional modulation of pain. Finally, we argue that the analysis of brain networks and spontaneous oscillations may be a crucial future development in the study of attentional modulation of pain, and why the interplay between attention and pain, as examined so far, may rely on neural mechanisms shared with other sensory modalities. Copyright © 2017 Elsevier Ltd. All rights reserved.

Magneto-transport properties of a two-dimensional electron gas under lateral periodic modulation

NASA Astrophysics Data System (ADS)

Shi, Qinwei

Several physical systems related to two-dimensional electron gas (2DEG) subjected to an electric or a magnetic modulation at various strength have been theoretically studied. In Chapter 3, a quantum transport theory is developed for the calculation of magnetoresistance rhoxx in a 2DEG subjected to strong one-dimensional periodic potential and at low uniform magnetic field (the Weiss oscillations regime). The theory is based on the exact diagonalization of the Hamiltonian and the constant relaxation time approximation. The theoretical predictions are in good agreement with the experimental results. The discrepancy between the classical calculation and the experiment is removed in our quantum treatment. In particular, the quenching of the Weiss oscillations is understood in this framework. In Chapter 4, the non-perturbative method for electric modulated system (EMS) is used to calculate the magnetoresistance rhoxx for a magnetic modulated system (MMS), which is a 2DEG subjected to strong one-dimensional periodic magnetic modulation and at low uniform magnetic field. As the amplitude of magnetic modulation increases we first find a quenching of the low fields oscillations. This is similar to the quenching of the Weiss oscillations in the EMS case. As the strength of the magnetic modulation increases further, a new series of oscillations appears in our calculation. The temperature dependence of these new oscillations shows that the basic mechanism of these oscillations is similar to Weiss oscillations, and the origin can be identified with the extra term in the Hamiltonian for the MMS case. In Chapter 5, a self-consistent quantum transport theory is developed to calculate magnetocoductivities in a 2DEG subjected to strong one-dimensional periodic potential and at high uniform magnetic field (SdH oscillation regime). The theory is based on the self-consistent Born approximation (SCBA) for the randomly distributed short-range impurities together with an exact diagonalization of the Hamiltonian. Quantum oscillations of magneto conductivities as a function of the amplitude of electric modulation are calculated and the basic mechanism behind these oscillations is discussed. In chapter 6, a tight-binding model is used to discuss the energy spectrum of 2DEG subjected to a strong two-dimensional magnetic modulation and a uniform magnetic field corresponding to a rational value of magnetic flux per unit cell f=pqf0. Some symmetries broken in the case of one-dimensional magnetic modulation are recovered in the two-dimensional case. Furthermore, when q is even, the magnetic Bloch band is broken into q subbands; while for odd q, the magnetic Bloch band is broken into 2 q subbands. This has interesting implication on the magnetotransport properties as one changes f . Our energy spectrum is similar but more complex than the Hofstadter's butterfly. Some suggestions to observe the new fractal energy spectrum are made.

MEG evidence that the central auditory system simultaneously encodes multiple temporal cues.

PubMed

Simpson, Michael I G; Barnes, Gareth R; Johnson, Sam R; Hillebrand, Arjan; Singh, Krish D; Green, Gary G R

2009-09-01

Speech contains complex amplitude modulations that have envelopes with multiple temporal cues. The processing of these complex envelopes is not well explained by the classical models of amplitude modulation processing. This may be because the evidence for the models typically comes from the use of simple sinusoidal amplitude modulations. In this study we used magnetoencephalography (MEG) to generate source space current estimates of the steady-state responses to simple one-component amplitude modulations and to a two-component amplitude modulation. A two-component modulation introduces the simplest form of modulation complexity into the waveform; the summation of the two-modulation rates introduces a beat-like modulation at the difference frequency between the two modulation rates. We compared the cortical representations of responses to the one-component and two-component modulations. In particular, we show that the temporal complexity in the two-component amplitude modulation stimuli was preserved at the cortical level. The method of stimulus normalization that we used also allows us to interpret these results as evidence that the important feature in sound modulations is the relative depth of one modulation rate with respect to another, rather than the absolute carrier-to-sideband modulation depth. More generally, this may be interpreted as evidence that modulation detection accurately preserves a representation of the modulation envelope. This is an important observation with respect to models of modulation processing, as it suggests that models may need a dynamic processing step to effectively model non-stationary stimuli. We suggest that the classic modulation filterbank model needs to be modified to take these findings into account.

Prequantum classical statistical field theory: background field as a source of everything?

NASA Astrophysics Data System (ADS)

Khrennikov, Andrei

2011-07-01

Prequantum classical statistical field theory (PCSFT) is a new attempt to consider quantum mechanics (QM) as an emergent phenomenon, cf. with De Broglie's "double solution" approach, Bohmian mechanics, stochastic electrodynamics (SED), Nelson's stochastic QM and its generalization by Davidson, 't Hooft's models and their development by Elze. PCSFT is a comeback to a purely wave viewpoint on QM, cf. with early Schrodinger. There is no quantum particles at all, only waves. In particular, photons are simply wave-pulses of the classical electromagnetic field, cf. SED. Moreover, even massive particles are special "prequantum fields": the electron field, the neutron field, and so on. PCSFT claims that (sooner or later) people will be able to measure components of these fields: components of the "photonic field" (the classical electromagnetic field of low intensity), electronic field, neutronic field, and so on. At the moment we are able to produce quantum correlations as correlations of classical Gaussian random fields. In this paper we are interested in mathematical and physical reasons of usage of Gaussian fields. We consider prequantum signals (corresponding to quantum systems) as composed of a huge number of wave-pulses (on very fine prequantum time scale). We speculate that the prequantum background field (the field of "vacuum fluctuations") might play the role of a source of such pulses, i.e., the source of everything.

Quantum Limits of Space-to-Ground Optical Communications

NASA Technical Reports Server (NTRS)

Hemmati, H.; Dolinar, S.

2012-01-01

For a pure loss channel, the ultimate capacity can be achieved with classical coherent states (i.e., ideal laser light): (1) Capacity-achieving receiver (measurement) is yet to be determined. (2) Heterodyne detection approaches the ultimate capacity at high mean photon numbers. (3) Photon-counting approaches the ultimate capacity at low mean photon numbers. A number of current technology limits drive the achievable performance of free-space communication links. Approaching fundamental limits in the bandwidth-limited regime: (1) Heterodyne detection with high-order coherent-state modulation approaches ultimate limits. SOA improvements to laser phase noise, adaptive optics systems for atmospheric transmission would help. (2) High-order intensity modulation and photon-counting can approach heterodyne detection within approximately a factor of 2. This may have advantages over coherent detection in the presence of turbulence. Approaching fundamental limits in the photon-limited regime (1) Low-duty cycle binary coherent-state modulation (OOK, PPM) approaches ultimate limits. SOA improvements to laser extinction ratio, receiver dark noise, jitter, and blocking would help. (2) In some link geometries (near field links) number-state transmission could improve over coherent-state transmission

3D polarisation speckle as a demonstration of tensor version of the van Cittert-Zernike theorem for stochastic electromagnetic beams

NASA Astrophysics Data System (ADS)

Ma, Ning; Zhao, Juan; Hanson, Steen G.; Takeda, Mitsuo; Wang, Wei

2016-10-01

Laser speckle has received extensive studies of its basic properties and associated applications. In the majority of research on speckle phenomena, the random optical field has been treated as a scalar optical field, and the main interest has been concentrated on their statistical properties and applications of its intensity distribution. Recently, statistical properties of random electric vector fields referred to as Polarization Speckle have come to attract new interest because of their importance in a variety of areas with practical applications such as biomedical optics and optical metrology. Statistical phenomena of random electric vector fields have close relevance to the theories of speckles, polarization and coherence theory. In this paper, we investigate the correlation tensor for stochastic electromagnetic fields modulated by a depolarizer consisting of a rough-surfaced retardation plate. Under the assumption that the microstructure of the scattering surface on the depolarizer is as fine as to be unresolvable in our observation region, we have derived a relationship between the polarization matrix/coherency matrix for the modulated electric fields behind the rough-surfaced retardation plate and the coherence matrix under the free space geometry. This relation is regarded as entirely analogous to the van Cittert-Zernike theorem of classical coherence theory. Within the paraxial approximation as represented by the ABCD-matrix formalism, the three-dimensional structure of the generated polarization speckle is investigated based on the correlation tensor, indicating a typical carrot structure with a much longer axial dimension than the extent in its transverse dimension.

Improved CORF model of simple cell combined with non-classical receptive field and its application on edge detection

NASA Astrophysics Data System (ADS)

Sun, Xiao; Chai, Guobei; Liu, Wei; Bao, Wenzhuo; Zhao, Xiaoning; Ming, Delie

2018-02-01

Simple cells in primary visual cortex are believed to extract local edge information from a visual scene. In this paper, inspired by different receptive field properties and visual information flow paths of neurons, an improved Combination of Receptive Fields (CORF) model combined with non-classical receptive fields was proposed to simulate the responses of simple cell's receptive fields. Compared to the classical model, the proposed model is able to better imitate simple cell's physiologic structure with consideration of facilitation and suppression of non-classical receptive fields. And on this base, an edge detection algorithm as an application of the improved CORF model was proposed. Experimental results validate the robustness of the proposed algorithm to noise and background interference.

Chemical genomics in plant biology.

PubMed

Sadhukhan, Ayan; Sahoo, Lingaraj; Panda, Sanjib Kumar

2012-06-01

Chemical genomics is a newly emerged and rapidly progressing field in biology, where small chemical molecules bind specifically and reversibly to protein(s) to modulate their function(s), leading to the delineation and subsequent unravelling of biological processes. This approach overcomes problems like lethality and redundancy of classical genetics. Armed with the powerful techniques of combinatorial synthesis, high-throughput screening and target discovery chemical genomics expands its scope to diverse areas in biology. The well-established genetic system of Arabidopsis model allows chemical genomics to enter into the realm of plant biology exploring signaling pathways of growth regulators, endomembrane signaling cascades, plant defense mechanisms and many more events.

The control of electron quantum trajectories on the high-order harmonic generation of CO and N2 molecules in the presence of a low frequency field.

PubMed

Koushki, A M; Sadighi-Bonabi, R; Mohsen-Nia, M; Irani, E

2018-04-14

In the present work, an efficient method is theoretically investigated for extending high-order harmonics and ultrashort attosecond pulse generation in N 2 and CO molecules by using the time-dependent density functional theory approach. Our results show that by utilizing chirped laser field in the presence of a low frequency field, not only is the harmonic cutoff extended remarkably but also the single short quantum trajectory is selected to contribute to the harmonic spectra. When a low frequency field is added to the two-color chirped laser field, the long quantum trajectories are suppressed and only the short quantum trajectories contribute to the higher harmonic emission mechanism. As a result, the spectral modulation is significantly decreased and an intense ultrashort pulse can be generated from the supercontinuum region of high harmonics. With such a scheme, the isolated ultrashort attosecond pulses can be generated in length, velocity, and acceleration gauges. Furthermore, these results are explained by using the classical and quantum time-frequency analyses.

The control of electron quantum trajectories on the high-order harmonic generation of CO and N2 molecules in the presence of a low frequency field

NASA Astrophysics Data System (ADS)

Koushki, A. M.; Sadighi-Bonabi, R.; Mohsen-Nia, M.; Irani, E.

2018-04-01

In the present work, an efficient method is theoretically investigated for extending high-order harmonics and ultrashort attosecond pulse generation in N2 and CO molecules by using the time-dependent density functional theory approach. Our results show that by utilizing chirped laser field in the presence of a low frequency field, not only is the harmonic cutoff extended remarkably but also the single short quantum trajectory is selected to contribute to the harmonic spectra. When a low frequency field is added to the two-color chirped laser field, the long quantum trajectories are suppressed and only the short quantum trajectories contribute to the higher harmonic emission mechanism. As a result, the spectral modulation is significantly decreased and an intense ultrashort pulse can be generated from the supercontinuum region of high harmonics. With such a scheme, the isolated ultrashort attosecond pulses can be generated in length, velocity, and acceleration gauges. Furthermore, these results are explained by using the classical and quantum time-frequency analyses.

Electron path control of high-order harmonic generation by a spatially inhomogeneous field

NASA Astrophysics Data System (ADS)

Mohebbi, Masoud; Nazarpoor Malaei, Sakineh

2016-04-01

We theoretically investigate the control of high-order harmonics cut-off and as-pulse generation by a chirped laser field using a metallic bow tie-shaped nanostructure. The numerical results show that the trajectories of the electron wave packet are strongly modified, the short quantum path is enhanced, the long quantum path is suppressed and the low modulated spectrum of the harmonics can be remarkably extended. Our calculated results also show that, by confining electron motion, a broadband supercontinuum with the width of 1670 eV can be produced which directly generates an isolated 34 as-pulse without phase compensation. To explore the underlying mechanism responsible for the cut-off extension and the quantum path selection, we perform time-frequency analysis and a classical simulation based on the three-step model.

Leading-order classical Lagrangians for the nonminimal standard-model extension

NASA Astrophysics Data System (ADS)

Reis, J. A. A. S.; Schreck, M.

2018-03-01

In this paper, we derive the general leading-order classical Lagrangian covering all fermion operators of the nonminimal standard-model extension (SME). Such a Lagrangian is considered to be the point-particle analog of the effective field theory description of Lorentz violation that is provided by the SME. At leading order in Lorentz violation, the Lagrangian obtained satisfies the set of five nonlinear equations that govern the map from the field theory to the classical description. This result can be of use for phenomenological studies of classical bodies in gravitational fields.

Classical and quantum Big Brake cosmology for scalar field and tachyonic models

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kamenshchik, A. Yu.; Manti, S.

We study a relation between the cosmological singularities in classical and quantum theory, comparing the classical and quantum dynamics in some models possessing the Big Brake singularity - the model based on a scalar field and two models based on a tachyon-pseudo-tachyon field . It is shown that the effect of quantum avoidance is absent for the soft singularities of the Big Brake type while it is present for the Big Bang and Big Crunch singularities. Thus, there is some kind of a classical - quantum correspondence, because soft singularities are traversable in classical cosmology, while the strong Big Bangmore » and Big Crunch singularities are not traversable.« less

Bosonic Loop Diagrams as Perturbative Solutions of the Classical Field Equations in ϕ4-Theory

NASA Astrophysics Data System (ADS)

Finster, Felix; Tolksdorf, Jürgen

2012-05-01

Solutions of the classical ϕ4-theory in Minkowski space-time are analyzed in a perturbation expansion in the nonlinearity. Using the language of Feynman diagrams, the solution of the Cauchy problem is expressed in terms of tree diagrams which involve the retarded Green's function and have one outgoing leg. In order to obtain general tree diagrams, we set up a "classical measurement process" in which a virtual observer of a scattering experiment modifies the field and detects suitable energy differences. By adding a classical stochastic background field, we even obtain all loop diagrams. The expansions are compared with the standard Feynman diagrams of the corresponding quantum field theory.

Quantum and classical behavior in interacting bosonic systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hertzberg, Mark P.

It is understood that in free bosonic theories, the classical field theory accurately describes the full quantum theory when the occupancy numbers of systems are very large. However, the situation is less understood in interacting theories, especially on time scales longer than the dynamical relaxation time. Recently there have been claims that the quantum theory deviates spectacularly from the classical theory on this time scale, even if the occupancy numbers are extremely large. Furthermore, it is claimed that the quantum theory quickly thermalizes while the classical theory does not. The evidence for these claims comes from noticing a spectacular differencemore » in the time evolution of expectation values of quantum operators compared to the classical micro-state evolution. If true, this would have dramatic consequences for many important phenomena, including laboratory studies of interacting BECs, dark matter axions, preheating after inflation, etc. In this work we critically examine these claims. We show that in fact the classical theory can describe the quantum behavior in the high occupancy regime, even when interactions are large. The connection is that the expectation values of quantum operators in a single quantum micro-state are approximated by a corresponding classical ensemble average over many classical micro-states. Furthermore, by the ergodic theorem, a classical ensemble average of local fields with statistical translation invariance is the spatial average of a single micro-state. So the correlation functions of the quantum and classical field theories of a single micro-state approximately agree at high occupancy, even in interacting systems. Furthermore, both quantum and classical field theories can thermalize, when appropriate coarse graining is introduced, with the classical case requiring a cutoff on low occupancy UV modes. We discuss applications of our results.« less

Calculations on Isotope Separation by Laser Induced Photodissociation of Polyatomic Molecules. Final Report

DOE R&D Accomplishments Database

Lamb, W. E. Jr.

1978-11-01

This report describes research on the theory of isotope separation produced by the illumination of polyatomic molecules by intense infrared laser radiation. Newton`s equations of motion were integrated for the atoms of the SF{sub 6} molecule including the laser field interaction. The first year`s work has been largely dedicated to obtaining a suitable interatomic potential valid for arbitrary configurations of the seven particles. This potential gives the correct symmetry of the molecule, the equilibrium configuration, the frequencies of the six distinct normal modes of oscillation and the correct (or assumed) value of the total potential energy of the molecule. Other conditions can easily be imposed in order to obtain a more refined potential energy function, for example, by making allowance for anharmonicity data. A suitable expression was also obtained for the interaction energy between a laser field and the polyatomic molecule. The electromagnetic field is treated classically, and it would be easily possible to treat the cases of time dependent pulses, frequency modulation and noise.

Quantum versus classical hyperfine-induced dynamics in a quantum dota)

NASA Astrophysics Data System (ADS)

Coish, W. A.; Loss, Daniel; Yuzbashyan, E. A.; Altshuler, B. L.

2007-04-01

In this article we analyze spin dynamics for electrons confined to semiconductor quantum dots due to the contact hyperfine interaction. We compare mean-field (classical) evolution of an electron spin in the presence of a nuclear field with the exact quantum evolution for the special case of uniform hyperfine coupling constants. We find that (in this special case) the zero-magnetic-field dynamics due to the mean-field approximation and quantum evolution are similar. However, in a finite magnetic field, the quantum and classical solutions agree only up to a certain time scale t <τc, after which they differ markedly.

Quantum correlations and dynamics from classical random fields valued in complex Hilbert spaces

DOE Office of Scientific and Technical Information (OSTI.GOV)

Khrennikov, Andrei

2010-08-15

One of the crucial differences between mathematical models of classical and quantum mechanics (QM) is the use of the tensor product of the state spaces of subsystems as the state space of the corresponding composite system. (To describe an ensemble of classical composite systems, one uses random variables taking values in the Cartesian product of the state spaces of subsystems.) We show that, nevertheless, it is possible to establish a natural correspondence between the classical and the quantum probabilistic descriptions of composite systems. Quantum averages for composite systems (including entangled) can be represented as averages with respect to classical randommore » fields. It is essentially what Albert Einstein dreamed of. QM is represented as classical statistical mechanics with infinite-dimensional phase space. While the mathematical construction is completely rigorous, its physical interpretation is a complicated problem. We present the basic physical interpretation of prequantum classical statistical field theory in Sec. II. However, this is only the first step toward real physical theory.« less

Inference of developmental gene regulatory networks beyond classical model systems: new approaches in the post-genomic era.

PubMed

Fernandez-Valverde, Selene L; Aguilera, Felipe; Ramos-Díaz, René Alexander

2018-06-18

The advent of high-throughput sequencing technologies has revolutionized the way we understand the transformation of genetic information into morphological traits. Elucidating the network of interactions between genes that govern cell differentiation through development is one of the core challenges in genome research. These networks are known as developmental gene regulatory networks (dGRNs) and consist largely of the functional linkage between developmental control genes, cis-regulatory modules and differentiation genes, which generate spatially and temporally refined patterns of gene expression. Over the last 20 years, great advances have been made in determining these gene interactions mainly in classical model systems, including human, mouse, sea urchin, fruit fly, and worm. This has brought about a radical transformation in the fields of developmental biology and evolutionary biology, allowing the generation of high-resolution gene regulatory maps to analyse cell differentiation during animal development. Such maps have enabled the identification of gene regulatory circuits and have led to the development of network inference methods that can recapitulate the differentiation of specific cell-types or developmental stages. In contrast, dGRN research in non-classical model systems has been limited to the identification of developmental control genes via the candidate gene approach and the characterization of their spatiotemporal expression patterns, as well as to the discovery of cis-regulatory modules via patterns of sequence conservation and/or predicted transcription-factor binding sites. However, thanks to the continuous advances in high-throughput sequencing technologies, this scenario is rapidly changing. Here, we give a historical overview on the architecture and elucidation of the dGRNs. Subsequently, we summarize the approaches available to unravel these regulatory networks, highlighting the vast range of possibilities of integrating multiple technical advances and theoretical approaches to expand our understanding on the global of gene regulation during animal development in non-classical model systems. Such new knowledge will not only lead to greater insights into the evolution of molecular mechanisms underlying cell identity and animal body plans, but also into the evolution of morphological key innovations in animals.

The Structure–Function Relationships of Classical Cannabinoids: CB1/CB2 Modulation

PubMed Central

Bow, Eric W.; Rimoldi, John M.

2016-01-01

The cannabinoids are members of a deceptively simple class of terpenophenolic secondary metabolites isolated from Cannabis sativa highlighted by (−)-Δ9-tetrahydrocannabinol (THC), eliciting distinct pharmacological effects mediated largely by cannabinoid receptor (CB1 or CB2) signaling. Since the initial discovery of THC and related cannabinoids, synthetic and semisynthetic classical cannabinoid analogs have been evaluated to help define receptor binding modes and structure–CB1/CB2 functional activity relationships. This perspective will examine the classical cannabinoids, with particular emphasis on the structure–activity relationship of five regions: C3 side chain, phenolic hydroxyl, aromatic A-ring, pyran B-ring, and cyclohexenyl C-ring. Cumulative structure–activity relationship studies to date have helped define the critical structural elements required for potency and selectivity toward CB1 and CB2 and, more importantly, ushered the discovery and development of contemporary nonclassical cannabinoid modulators with enhanced physicochemical and pharmacological profiles. PMID:27398024

QTL and systems genetics analysis of mouse grooming and behavioral responses to novelty in an open field.

PubMed

Delprato, A; Algéo, M-P; Bonheur, B; Bubier, J A; Lu, L; Williams, R W; Chesler, E J; Crusio, W E

2017-11-01

The open field is a classic test used to assess exploratory behavior, anxiety and locomotor activity in rodents. Here, we mapped quantitative trait loci (QTLs) underlying behaviors displayed in an open field, using a panel of 53 BXD recombinant inbred mouse strains with deep replication (10 per strain and sex). The use of these strains permits the integration and comparison of data obtained in different laboratories, and also offers the possibility to study trait covariance by exploiting powerful bioinformatics tools and resources. We quantified behavioral traits during 20-min test sessions including (1) percent time spent and distance traveled near the wall (thigmotaxis), (2) leaning against the wall, (3) rearing, (4) jumping, (5) grooming duration, (6) grooming frequency, (7) locomotion and (8) defecation. All traits exhibit moderate heritability making them amenable to genetic analysis. We identified a significant QTL on chromosome M.m. 4 at approximately 104 Mb that modulates grooming duration in both males and females (likelihood ratio statistic values of approximately 18, explaining 25% and 14% of the variance, respectively) and a suggestive QTL modulating locomotion that maps to the same locus. Bioinformatic analysis indicates Disabled 1 (Dab1, a key protein in the reelin signaling pathway) as a particularly strong candidate gene modulating these behaviors. We also found 2 highly suggestive QTLs for a sex by strain interaction for grooming duration on chromosomes 13 and 17. In addition, we identified a pairwise epistatic interaction between loci on chromosomes 12 at 36-37 Mb and 14 at 34-36 Mb that influences rearing frequency in males. © 2017 John Wiley & Sons Ltd and International Behavioural and Neural Genetics Society.

Evolution of the radial electric field in high-Te ECH heated plasmas on LHD

NASA Astrophysics Data System (ADS)

Pablant, Novimir; Bitter, Manfred; Delgado Aparicio, Luis F.; Dinklage, Andreas; Gates, David; Goto, Motoshi; Ido, Takeshi; Hill, Kenneth H.; Kubo, Shin; Morita, Shigeru; Nagaoka, Kenichi; Oishi, Tetsutarou; Satake, Shinsuke; Takahashi, Hiromi; Yokoyama, Masayuki; LHD Experiment Group Team

2014-10-01

A detailed study is presented on the evolution of the radial electric field (Er) under a range of densities and injected ECH powers on the Large Helical Device (LHD). These plasmas focused on high-electron temperature ECH heated plasmas which exhibit a transition of Er from the ion-root to the electron-root when either the density is reduced or the ECH power is increased. Measurements of poloidal rotation were achieved using the X-Ray Imaging Crystal Spectrometer (XICS) and are compared with neo-classical predictions of the radial electric field using the GSRAKE and FORTEC-3D codes. This study is based on a series of experiments on LHD which used fast modulation of the gyrotrons on LHD to produce a detailed power scan with a constant power deposition profile. This is a novel application of this technique to LHD, and has provided the most detailed study to date on dependence of the radial electric field on the injected power. Detailed scans of the density at constant injected power were also made, allowing a separation of the power and density dependence.

Contextual Modulation is Related to Efficiency in a Spiking Network Model of Visual Cortex.

PubMed

Sharifian, Fariba; Heikkinen, Hanna; Vigário, Ricardo; Vanni, Simo

2015-01-01

In the visual cortex, stimuli outside the classical receptive field (CRF) modulate the neural firing rate, without driving the neuron by themselves. In the primary visual cortex (V1), such contextual modulation can be parametrized with an area summation function (ASF): increasing stimulus size causes first an increase and then a decrease of firing rate before reaching an asymptote. Earlier work has reported increase of sparseness when CRF stimulation is extended to its surroundings. However, there has been no clear connection between the ASF and network efficiency. Here we aimed to investigate possible link between ASF and network efficiency. In this study, we simulated the responses of a biomimetic spiking neural network model of the visual cortex to a set of natural images. We varied the network parameters, and compared the V1 excitatory neuron spike responses to the corresponding responses predicted from earlier single neuron data from primate visual cortex. The network efficiency was quantified with firing rate (which has direct association to neural energy consumption), entropy per spike and population sparseness. All three measures together provided a clear association between the network efficiency and the ASF. The association was clear when varying the horizontal connectivity within V1, which influenced both the efficiency and the distance to ASF, DAS. Given the limitations of our biophysical model, this association is qualitative, but nevertheless suggests that an ASF-like receptive field structure can cause efficient population response.

Divide and Conquer: A Valid Approach for Risk Assessment and Decision Making under Uncertainty for Groundwater-Related Diseases

NASA Astrophysics Data System (ADS)

Sanchez-Vila, X.; de Barros, F.; Bolster, D.; Nowak, W.

2010-12-01

Assessing the potential risk of hydro(geo)logical supply systems to human population is an interdisciplinary field. It relies on the expertise in fields as distant as hydrogeology, medicine, or anthropology, and needs powerful translation concepts to provide decision support and policy making. Reliable health risk estimates need to account for the uncertainties in hydrological, physiological and human behavioral parameters. We propose the use of fault trees to address the task of probabilistic risk analysis (PRA) and to support related management decisions. Fault trees allow decomposing the assessment of health risk into individual manageable modules, thus tackling a complex system by a structural “Divide and Conquer” approach. The complexity within each module can be chosen individually according to data availability, parsimony, relative importance and stage of analysis. The separation in modules allows for a true inter- and multi-disciplinary approach. This presentation highlights the three novel features of our work: (1) we define failure in terms of risk being above a threshold value, whereas previous studies used auxiliary events such as exceedance of critical concentration levels, (2) we plot an integrated fault tree that handles uncertainty in both hydrological and health components in a unified way, and (3) we introduce a new form of stochastic fault tree that allows to weaken the assumption of independent subsystems that is required by a classical fault tree approach. We illustrate our concept in a simple groundwater-related setting.

An indirect method of imaging the Stokes parameters of a submicron particle with sub-diffraction scattering

NASA Astrophysics Data System (ADS)

Ullah, Kaleem; Garcia-Camara, Braulio; Habib, Muhammad; Yadav, N. P.; Liu, Xuefeng

2018-07-01

In this work, we report an indirect way to image the Stokes parameters of a sample under test (SUT) with sub-diffraction scattering information. We apply our previously reported technique called parametric indirect microscopic imaging (PIMI) based on a fitting and filtration process to measure the Stokes parameters of a submicron particle. A comparison with a classical Stokes measurement is also shown. By modulating the incident field in a precise way, fitting and filtration process at each pixel of the detector in PIMI make us enable to resolve and sense the scattering information of SUT and map them in terms of the Stokes parameters. We believe that our finding can be very useful in fields like singular optics, optical nanoantenna, biomedicine and much more. The spatial signature of the Stokes parameters given by our method has been confirmed with finite difference time domain (FDTD) method.

Sub-Nyquist Sampling and Moire-Like Waveform Distortions

NASA Technical Reports Server (NTRS)

Williams, Glenn L.

2000-01-01

Investigations of aliasing effects in digital waveform sampling have revealed the existence of a mathematical field and a pseudo-alias domain lying to the left of a "Nyquist line" in a plane defining the boundary between two domains of sampling. To the right of the line lies the classic alias domain. For signals band-limited below the Nyquist limit, displayed output may show a false modulation envelope. The effect occurs whenever the sample rate and the signal frequency are related by ratios of mutually prime integers. Belying the principal of a 10:1 sampling ratio being "good enough", this distortion easily occurs in graphed one-dimensional waveforms and two-dimensional images and occurs daily on television.

Probing quantum frustrated systems via factorization of the ground state.

PubMed

Giampaolo, Salvatore M; Adesso, Gerardo; Illuminati, Fabrizio

2010-05-21

The existence of definite orders in frustrated quantum systems is related rigorously to the occurrence of fully factorized ground states below a threshold value of the frustration. Ground-state separability thus provides a natural measure of frustration: strongly frustrated systems are those that cannot accommodate for classical-like solutions. The exact form of the factorized ground states and the critical frustration are determined for various classes of nonexactly solvable spin models with different spatial ranges of the interactions. For weak frustration, the existence of disentangling transitions determines the range of applicability of mean-field descriptions in biological and physical problems such as stochastic gene expression and the stability of long-period modulated structures.

Emerging Roles for Eosinophils in the Tumor Microenvironment.

PubMed

Reichman, Hadar; Karo-Atar, Danielle; Munitz, Ariel

2016-11-01

Eosinophils are evolutionary conserved cells largely studied in the context of allergy. Although eosinophils were first described in tumors more than 120 years ago, their roles in cancer are often overlooked. This is puzzling given their potent immune modulatory, cytotoxic, and/or tissue repair capabilities, and recent studies demonstrating key roles for eosinophils in contexts far beyond their 'classical' field (e.g., metabolism, thermogenesis, and tissue regeneration). Recent data suggest that this frequently ignored cell is emerging as a potent immune effector and immune modulator in the tumor microenvironment. This review discusses the relevance of eosinophils to tumorigenesis and the potential to harness their function in cancer therapies. Copyright © 2016 Elsevier Inc. All rights reserved.

Non-classical Correlations and Quantum Coherence in Mixed Environments

NASA Astrophysics Data System (ADS)

Hu, Zheng-Da; Wei, Mei-Song; Wang, Jicheng; Zhang, Yixin; He, Qi-Liang

2018-05-01

We investigate non-classical correlations (entanglement and quantum discord) and quantum coherence for an open two-qubit system each independently coupled to a bosonic environment and a spin environment, respectively. The modulating effects of spin environment and bosonic environment are respectively explored. A relation among the quantum coherence, quantum discord and classical correlation is found during the sudden transition phenomenon. We also compare the case of mixed environments with that of the same environments, showing that the dynamics is dramatically changed.

Aerosol scattering and absorption modulation transfer function

NASA Astrophysics Data System (ADS)

Sadot, Dan; Kopeika, Norman S.

1993-08-01

Recent experimental measurements of overall atmospheric modulation transfer function (MTF) indicate significant difference between the turbulence and overall atmospheric MTFs, except often at midday when turbulence is strong. We suggest here a physical explanation for those results which essentially relates to what we call a practical instrumentation-based atmospheric aerosol MTF which is a modification of the classical aerosol MTF theory. It is shown that system field-of-view and dynamic range affect strongly aerosol and overall atmospheric MTFs. It is often necessary to choose between MTF and SNR depending upon dynamic range requirements. Also, a new approach regarding aerosol absorption is presented. It is shown that aerosol-absorbed irradiance is spatial frequency dependent and enhances the degradation in image quality arising from received scattered light. This is most relevant for thermal imaging. An analytically corrected model for the aerosol MTF is presented which is relevant for imaging. An important conclusion is that the aerosol MTF is often the dominant part in the actual overall atmospheric MTF all across the optical spectral region.

Predicted contextual modulation varies with distance from pinwheel centers in the orientation preference map

PubMed Central

Okamoto, Tsuyoshi; Ikezoe, Koji; Tamura, Hiroshi; Watanabe, Masataka; Aihara, Kazuyuki; Fujita, Ichiro

2011-01-01

In the primary visual cortex (V1) of some mammals, columns of neurons with the full range of orientation preferences converge at the center of a pinwheel-like arrangement, the ‘pinwheel center' (PWC). Because a neuron receives abundant inputs from nearby neurons, the neuron's position on the cortical map likely has a significant impact on its responses to the layout of orientations inside and outside its classical receptive field (CRF). To understand the positional specificity of responses, we constructed a computational model based on orientation preference maps in monkey V1 and hypothetical neuronal connections. The model simulations showed that neurons near PWCs displayed weaker but detectable orientation selectivity within their CRFs, and strongly reduced contextual modulation from extra-CRF stimuli, than neurons distant from PWCs. We suggest that neurons near PWCs robustly extract local orientation within their CRF embedded in visual scenes, and that contextual information is processed in regions distant from PWCs. PMID:22355631

Tailoring recombinant protein quality by rational media design.

PubMed

Brühlmann, David; Jordan, Martin; Hemberger, Jürgen; Sauer, Markus; Stettler, Matthieu; Broly, Hervé

2015-01-01

Clinical efficacy and safety of recombinant proteins are closely associated with their structural characteristics. The major quality attributes comprise glycosylation, charge variants (oxidation, deamidation, and C- & N-terminal modifications), aggregates, low-molecular-weight species (LMW), and misincorporation of amino acids in the protein backbone. Cell culture media design has a great potential to modulate these quality attributes due to the vital role of medium in mammalian cell culture. The purpose of this review is to provide an overview of the way both classical cell culture medium components and novel supplements affect the quality attributes of recombinant therapeutic proteins expressed in mammalian hosts, allowing rational and high-throughput optimization of mammalian cell culture media. A selection of specific and/or potent inhibitors and activators of oligosaccharide processing as well as components affecting multiple quality attributes are presented. Extensive research efforts in this field show the feasibility of quality engineering through media design, allowing to significantly modulate the protein function. © 2015 American Institute of Chemical Engineers.

Holographic calculation for large interval Rényi entropy at high temperature

NASA Astrophysics Data System (ADS)

Chen, Bin; Wu, Jie-qiang

2015-11-01

In this paper, we study the holographic Rényi entropy of a large interval on a circle at high temperature for the two-dimensional conformal field theory (CFT) dual to pure AdS3 gravity. In the field theory, the Rényi entropy is encoded in the CFT partition function on n -sheeted torus connected with each other by a large branch cut. As proposed by Chen and Wu [Large interval limit of Rényi entropy at high temperature, arXiv:1412.0763], the effective way to read the entropy in the large interval limit is to insert a complete set of state bases of the twist sector at the branch cut. Then the calculation transforms into an expansion of four-point functions in the twist sector with respect to e-2/π T R n . By using the operator product expansion of the twist operators at the branch points, we read the first few terms of the Rényi entropy, including the leading and next-to-leading contributions in the large central charge limit. Moreover, we show that the leading contribution is actually captured by the twist vacuum module. In this case by the Ward identity the four-point functions can be derived from the correlation function of four twist operators, which is related to double interval entanglement entropy. Holographically, we apply the recipe in [T. Faulkner, The entanglement Rényi entropies of disjoint intervals in AdS/CFT, arXiv:1303.7221] and [T. Barrella et al., Holographic entanglement beyond classical gravity, J. High Energy Phys. 09 (2013) 109] to compute the classical Rényi entropy and its one-loop quantum correction, after imposing a new set of monodromy conditions. The holographic classical result matches exactly with the leading contribution in the field theory up to e-4 π T R and l6, while the holographical one-loop contribution is in exact agreement with next-to-leading results in field theory up to e-6/π T R n and l4 as well.

The Multiphoton Interaction of Lambda Model Atom and Two-Mode Fields

NASA Technical Reports Server (NTRS)

Liu, Tang-Kun

1996-01-01

The system of two-mode fields interacting with atom by means of multiphotons is addressed, and the non-classical statistic quality of two-mode fields with interaction is discussed. Through mathematical calculation, some new rules of non-classical effects of two-mode fields which evolue with time, are established.

Spatial and temporal modulation of joint stiffness during multijoint movement.

PubMed

Mah, C D

2001-02-01

Joint stiffness measurements during small transient perturbations have suggested that stiffness during movement is different from that observed during posture. These observations are problematic for theories like the classical equilibrium point hypothesis, which suggest that desired trajectories during movement are enforced by joint stiffness. We measured arm impedances during large, slow perturbations to obtain detailed information about the spatial and temporal modulation of stiffness and viscosity during movement. While our measurements of stiffness magnitudes during movement generally agreed with the results of measurements using fast perturbations, they revealed that joint stiffness undergoes stereotyped changes in magnitude and aspect ratio which depend on the direction of movement and show a strong dependence on joint angles. Movement simulations using measured parameters show that the measured modulation of impedance acts as an energy conserving force field to constrain movement. This mechanism allows for a computationally simplified account of the execution of multijoint movement. While our measurements do not rule out a role for afferent feedback in force generation, the observed stereotyped restoring forces can allow a dramatic relaxation of the accuracy requirements for forces generated by other control mechanisms, such as inverse dynamical models.

Classical electromagnetic fields from quantum sources in heavy-ion collisions

NASA Astrophysics Data System (ADS)

Holliday, Robert; McCarty, Ryan; Peroutka, Balthazar; Tuchin, Kirill

2017-01-01

Electromagnetic fields are generated in high energy nuclear collisions by spectator valence protons. These fields are traditionally computed by integrating the Maxwell equations with point sources. One might expect that such an approach is valid at distances much larger than the proton size and thus such a classical approach should work well for almost the entire interaction region in the case of heavy nuclei. We argue that, in fact, the contrary is true: due to the quantum diffusion of the proton wave function, the classical approximation breaks down at distances of the order of the system size. We compute the electromagnetic field created by a charged particle described initially as a Gaussian wave packet of width 1 fm and evolving in vacuum according to the Klein-Gordon equation. We completely neglect the medium effects. We show that the dynamics, magnitude and even sign of the electromagnetic field created by classical and quantum sources are different.

Constraints on primordial magnetic fields from inflation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Green, Daniel; Kobayashi, Takeshi, E-mail: drgreen@cita.utoronto.ca, E-mail: takeshi.kobayashi@sissa.it

2016-03-01

We present generic bounds on magnetic fields produced from cosmic inflation. By investigating field bounds on the vector potential, we constrain both the quantum mechanical production of magnetic fields and their classical growth in a model independent way. For classical growth, we show that only if the reheating temperature is as low as T{sub reh} ∼< 10{sup 2} MeV can magnetic fields of 10{sup −15} G be produced on Mpc scales in the present universe. For purely quantum mechanical scenarios, even stronger constraints are derived. Our bounds on classical and quantum mechanical scenarios apply to generic theories of inflationary magnetogenesis with a two-derivative timemore » kinetic term for the vector potential. In both cases, the magnetic field strength is limited by the gravitational back-reaction of the electric fields that are produced simultaneously. As an example of quantum mechanical scenarios, we construct vector field theories whose time diffeomorphisms are spontaneously broken, and explore magnetic field generation in theories with a variable speed of light. Transitions of quantum vector field fluctuations into classical fluctuations are also analyzed in the examples.« less

Scattering of classical and quantum particles by impulsive fields

NASA Astrophysics Data System (ADS)

Balasin, Herbert; Aichelburg, Peter C.

2018-05-01

We investigate the scattering of classical and quantum particles in impulsive backgrounds fields. These fields model short outbursts of radiation propagating with the speed of light. The singular nature of the problem will be accounted for by the use of Colombeau’s generalized function which however give rise to ambiguities. It is the aim of the paper to show that these ambiguities can be overcome by implementing additional physical conditions, which in the non-singular case would be satisfied automatically. As example we discuss the scattering of classical, Klein–Gordon and Dirac particles in impulsive electromagnetic fields.

Fluctuating local field method probed for a description of small classical correlated lattices

NASA Astrophysics Data System (ADS)

Rubtsov, Alexey N.

2018-05-01

Thermal-equilibrated finite classical lattices are considered as a minimal model of the systems showing an interplay between low-energy collective fluctuations and single-site degrees of freedom. Standard local field approach, as well as classical limit of the bosonic DMFT method, do not provide a satisfactory description of Ising and Heisenberg small lattices subjected to an external polarizing field. We show that a dramatic improvement can be achieved within a simple approach, in which the local field appears to be a fluctuating quantity related to the low-energy degree(s) of freedom.

Russ Donnelly's research at the University of Oregon

NASA Astrophysics Data System (ADS)

Niemela, Joseph

2015-11-01

Coming to the University of Oregon in 1966, Russ Donnelly built up a strong research activity having two threads within hydrodynamics: the flow of ordinary fluids and that of superfluids. Vortices-quantized and classical-were at the heart of his research. His 1991 book ``Quantized Vortices in Helium II,'' by now a standard reference for researchers and students, elucidated some of it. To produce vortices Russ brought from Chicago two enormous rotating tables, based on 1-m diameter industrial lathe chucks obtained from General Motors. They were also used for classical systems such as Taylor-Couette flow (to generate strong Coriolis forces) and thermal convection, where the properties of rotation-including early experimental investigations of the Kuppers-Lortz instability-were studied. Another common thread in his research was the modulation of control parameters leading to Stokes layer effects, both thermal and viscous. In the early `90s, Russ and his group turned their attention to cryogenic turbulence in normal and superfluid systems, creating what has now become a small industry and a well-established sub-field within low temperature physics.

Quantum Noise Reduction with Pulsed Light in Optical Fibers.

NASA Astrophysics Data System (ADS)

Bergman, Keren

Optical fibers offer considerable advantages over bulk nonlinear media for the generation of squeezed states. This thesis reports on experimental investigations of reducing quantum noise by means of squeezing in nonlinear fiber optic interferometers. Fibers have low insertion loss which allows for long interaction lengths. High field intensities are easily achieved in the small cores of single mode fibers. Additionally, the nonlinear process employed is self phase modulation or the Kerr effect, whose broad band nature requires no phase matching and can be exploited with ultra-short pulses of high peak intensity. All these advantageous features of fibers result in easily obtained large nonlinear phase shifts and subsequently large squeezing parameters. By the self phase modulation process a correlation is produced between the phase and amplitude fluctuations of the optical field. The attenuated or squeezed quadrature has a lower noise level than the initial level associated with the coherent state field before propagation. The resulting reduced quantum noise quadrature can be utilized to improve the sensitivity of a phase measuring instrument such as an interferometer. Because the Kerr nonlinearity is a degenerate self pumping process, the squeezed noise is at the same frequency as the pump field. Classical pump noise can therefore interfere with the desired measurement of the quantum noise reduction. The most severe noise process is the phase noise caused by thermally induced index modulation of the fiber. This noise termed Guided Acoustic Wave Brillouin Scattering, or GAWBS, by previous researchers is studied and analyzed. Experiments performed to overcome GAWBS successfully with several schemes are described. An experimental demonstration of an interferometric measurement with better sensitivity than the standard quantum limit is described. The results lead to new understandings into the limitations of quantum noise reduction that can be achieved in the laboratory. (Copies available exclusively from MIT Libraries, Rm. 14-0551, Cambridge, MA 02139-4307. Ph. 617-253-5668; Fax 617-253-1690.).

Quantum generalisation of feedforward neural networks

NASA Astrophysics Data System (ADS)

Wan, Kwok Ho; Dahlsten, Oscar; Kristjánsson, Hlér; Gardner, Robert; Kim, M. S.

2017-09-01

We propose a quantum generalisation of a classical neural network. The classical neurons are firstly rendered reversible by adding ancillary bits. Then they are generalised to being quantum reversible, i.e., unitary (the classical networks we generalise are called feedforward, and have step-function activation functions). The quantum network can be trained efficiently using gradient descent on a cost function to perform quantum generalisations of classical tasks. We demonstrate numerically that it can: (i) compress quantum states onto a minimal number of qubits, creating a quantum autoencoder, and (ii) discover quantum communication protocols such as teleportation. Our general recipe is theoretical and implementation-independent. The quantum neuron module can naturally be implemented photonically.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhang, Ying-Jie, E-mail: yingjiezhang@qfnu.edu.cn; Han, Wei; Xia, Yun-Jie, E-mail: yjxia@qfnu.edu.cn

We propose a scheme of controlling entanglement dynamics of a quantum system by applying the external classical driving field for two atoms separately located in a single-mode photon cavity. It is shown that, with a judicious choice of the classical-driving strength and the atom–photon detuning, the effective atom–photon interaction Hamiltonian can be switched from Jaynes–Cummings model to anti-Jaynes–Cummings model. By tuning the controllable atom–photon interaction induced by the classical field, we illustrate that the evolution trajectory of the Bell-like entanglement states can be manipulated from entanglement-sudden-death to no-entanglement-sudden-death, from no-entanglement-invariant to entanglement-invariant. Furthermore, the robustness of the initial Bell-like entanglementmore » can be improved by the classical driving field in the leaky cavities. This classical-driving-assisted architecture can be easily extensible to multi-atom quantum system for scalability.« less

Simulation of Subsurface Multiphase Contaminant Extraction Using a Bioslurping Well Model

DOE Office of Scientific and Technical Information (OSTI.GOV)

Matos de Souza, Michelle; Oostrom, Mart; White, Mark D.

2016-07-12

Subsurface simulation of multiphase extraction from wells is notoriously difficult. Explicit representation of well geometry requires small grid resolution, potentially leading to large computational demands. To reduce the problem dimensionality, multiphase extraction is mostly modeled using vertically-averaged approaches. In this paper, a multiphase well model approach is presented as an alternative to simplify the application. The well model, a multiphase extension of the classic Peaceman model, has been implemented in the STOMP simulator. The numerical solution approach accounts for local conditions and gradients in the exchange of fluids between the well and the aquifer. Advantages of this well model implementationmore » include the option to simulate the effects of well characteristics and operation. Simulations were conducted investigating the effects of extraction location, applied vacuum pressure, and a number of hydraulic properties. The obtained results were all consistent and logical. A major outcome of the test simulations is that, in contrast with common recommendations to extract from either the gas-NAPL or the NAPL-aqueous phase interface, the optimum extraction location should be in between these two levels. The new model implementation was also used to simulate extraction at a field site in Brazil. The simulation shows a good match with the field data, suggesting that the new STOMP well module may correctly represent oil removal. The field simulations depend on the quality of the site conceptual model, including the porous media and contaminant properties and the boundary and extraction conditions adopted. The new module may potentially be used to design field applications and analyze extraction data.« less

Non-Noetherian symmetries for oscillators in classical mechanics and in field theory

NASA Technical Reports Server (NTRS)

Hojman, Sergio A.; Delajara, Jamie; Pena, Leda

1995-01-01

Infinitely many new conservation laws both for free fields as well as for test fields evolving on a given gravitational background are presented. The conserved currents are constructed using the field theoretical counterpart of a recently discovered non-Noetherian symmetry which gives rise to a new way of solving the classical small oscillations problem. Several examples are discussed.

Investigating light curve modulation via kernel smoothing. II. New additional modes in single-mode OGLE classical Cepheids

NASA Astrophysics Data System (ADS)

Süveges, Maria; Anderson, Richard I.

2018-04-01

Detailed knowledge of the variability of classical Cepheids, in particular their modulations and mode composition, provides crucial insight into stellar structure and pulsation. However, tiny modulations of the dominant radial-mode pulsation were recently found to be very frequent, possibly ubiquitous in Cepheids, which makes secondary modes difficult to detect and analyse, since these modulations can easily mask the potentially weak secondary modes. The aim of this study is to re-investigate the secondary mode content in the sample of OGLE-III and -IV single-mode classical Cepheids using kernel regression with adaptive kernel width for pre-whitening, instead of using a constant-parameter model. This leads to a more precise removal of the modulated dominant pulsation, and enables a more complete survey of secondary modes with frequencies outside a narrow range around the primary. Our analysis reveals that significant secondary modes occur more frequently among first overtone Cepheids than previously thought. The mode composition appears significantly different in the Large and Small Magellanic Clouds, suggesting a possible dependence on chemical composition. In addition to the formerly identified non-radial mode at P2 ≈ 0.6…0.65P1 (0.62-mode), and a cluster of modes with near-primary frequency, we find two more candidate non-radial modes. One is a numerous group of secondary modes with P2 ≈ 1.25P1, which may represent the fundamental of the 0.62-mode, supposed to be the first harmonic of an l ∈ {7, 8, 9} non-radial mode. The other new mode is at P2 ≈ 1.46P1, possibly analogous to a similar, rare mode recently discovered among first overtone RR Lyrae stars.

Response of cardiac autonomic modulation after a single exposure to musical auditory stimulation

PubMed Central

Ferreira, Lucas L.; Vanderlei, Luiz Carlos M.; Guida, Heraldo L.; de Abreu, Luiz Carlos; Garner, David M.; Vanderlei, Franciele M.; Ferreira, Celso; Valenti, Vitor E.

2015-01-01

The acute effects after exposure to different styles of music on cardiac autonomic modulation assessed through heart rate variability (HRV) analysis have not yet been well elucidated. We aimed to investigate the recovery response of cardiac autonomic modulation in women after exposure to musical auditory stimulation of different styles. The study was conducted on 30 healthy women aged between 18 years and 30 years. We did not include subjects having previous experience with musical instruments and those who had an affinity for music styles. The volunteers remained at rest for 10 min and were exposed to classical baroque (64-84 dB) and heavy metal (75-84 dB) music for 10 min, and their HRV was evaluated for 30 min after music cessation. We analyzed the following HRV indices: Standard deviation of normal-to-normal (SDNN) intervals, root mean square of successive differences (RMSSD), percentage of normal-to-normal 50 (pNN50), low frequency (LF), high frequency (HF), and LF/HF ratio. SDNN, LF in absolute units (ms2) and normalized (nu), and LF/HF ratio increased while HF index (nu) decreased after exposure to classical baroque music. Regarding the heavy metal music style, it was observed that there were increases in SDNN, RMSSD, pNN50, and LF (ms2) after the musical stimulation. In conclusion, the recovery response of cardiac autonomic modulation after exposure to auditory stimulation with music featured an increased global activity of both systems for the two musical styles, with a cardiac sympathetic modulation for classical baroque music and a cardiac vagal tone for the heavy metal style. PMID:25774614

Quantized Detector Networks

NASA Astrophysics Data System (ADS)

Jaroszkiewicz, George

2017-12-01

Preface; Acronyms; 1. Introduction; 2. Questions and answers; 3. Classical bits; 4. Quantum bits; 5. Classical and quantum registers; 6. Classical register mechanics; 7. Quantum register dynamics; 8. Partial observations; 9. Mixed states and POVMs; 10. Double-slit experiments; 11. Modules; 12. Computerization and computer algebra; 13. Interferometers; 14. Quantum eraser experiments; 15. Particle decays; 16. Non-locality; 17. Bell inequalities; 18. Change and persistence; 19. Temporal correlations; 20. The Franson experiment; 21. Self-intervening networks; 22. Separability and entanglement; 23. Causal sets; 24. Oscillators; 25. Dynamical theory of observation; 26. Conclusions; Appendix; Index.

Phase coded, micro-power impulse radar motion sensor

DOEpatents

McEwan, Thomas E.

1996-01-01

A motion sensing, micro-power impulse radar MIR impresses on the transmitted signal, or the received pulse timing signal, one or more frequencies lower than the pulse repetition frequency, that become intermediate frequencies in a "IF homodyne" receiver. Thus, many advantages of classical RF receivers can be thereby be realized with ultra-wide band radar. The sensor includes a transmitter which transmits a sequence of electromagnetic pulses in response to a transmit timing signal at a nominal pulse repetition frequency. A receiver samples echoes of the sequence of electromagnetic pulses from objects within the field with controlled timing, in response to a receive timing signal, and generates a sample signal in response to the samples. A timing circuit supplies the transmit timing signal to the transmitter and supplies the receive timing signal to the receiver. The relative timing of the transmit timing signal and the receive timing signal is modulated between a first relative delay and a second relative delay at an intermediate frequency, causing the receiver to sample the echoes such that the time between transmissions of pulses in the sequence and samples by the receiver is modulated at the intermediate frequency. Modulation may be executed by modulating the pulse repetition frequency which drives the transmitter, by modulating the delay circuitry which controls the relative timing of the sample strobe, or by modulating amplitude of the transmitted pulses. The electromagnetic pulses will have a nominal center frequency related to pulse width, and the first relative delay and the second relative delay between which the timing signals are modulated, differ by less than the nominal pulse width, and preferably by about one-quarter wavelength at the nominal center frequency of the transmitted pulses.

Phase coded, micro-power impulse radar motion sensor

DOEpatents

McEwan, T.E.

1996-05-21

A motion sensing, micro-power impulse radar MIR impresses on the transmitted signal, or the received pulse timing signal, one or more frequencies lower than the pulse repetition frequency, that become intermediate frequencies in a ``IF homodyne`` receiver. Thus, many advantages of classical RF receivers can be thereby be realized with ultra-wide band radar. The sensor includes a transmitter which transmits a sequence of electromagnetic pulses in response to a transmit timing signal at a nominal pulse repetition frequency. A receiver samples echoes of the sequence of electromagnetic pulses from objects within the field with controlled timing, in response to a receive timing signal, and generates a sample signal in response to the samples. A timing circuit supplies the transmit timing signal to the transmitter and supplies the receive timing signal to the receiver. The relative timing of the transmit timing signal and the receive timing signal is modulated between a first relative delay and a second relative delay at an intermediate frequency, causing the receiver to sample the echoes such that the time between transmissions of pulses in the sequence and samples by the receiver is modulated at the intermediate frequency. Modulation may be executed by modulating the pulse repetition frequency which drives the transmitter, by modulating the delay circuitry which controls the relative timing of the sample strobe, or by modulating amplitude of the transmitted pulses. The electromagnetic pulses will have a nominal center frequency related to pulse width, and the first relative delay and the second relative delay between which the timing signals are modulated, differ by less than the nominal pulse width, and preferably by about one-quarter wavelength at the nominal center frequency of the transmitted pulses. 5 figs.

Extremely simple holographic projection of color images

NASA Astrophysics Data System (ADS)

Makowski, Michal; Ducin, Izabela; Kakarenko, Karol; Suszek, Jaroslaw; Kolodziejczyk, Andrzej; Sypek, Maciej

2012-03-01

A very simple scheme of holographic projection is presented with some experimental results showing good quality image projection without any imaging lens. This technique can be regarded as an alternative to classic projection methods. It is based on the reconstruction real images from three phase iterated Fourier holograms. The illumination is performed with three laser beams of primary colors. A divergent wavefront geometry is used to achieve an increased throw angle of the projection, compared to plane wave illumination. Light fibers are used as light guidance in order to keep the setup as simple as possible and to provide point-like sources of high quality divergent wave-fronts at optimized position against the light modulator. Absorbing spectral filters are implemented to multiplex three holograms on a single phase-only spatial light modulator. Hence color mixing occurs without any time-division methods, which cause rainbow effects and color flicker. The zero diffractive order with divergent illumination is practically invisible and speckle field is effectively suppressed with phase optimization and time averaging techniques. The main advantages of the proposed concept are: a very simple and highly miniaturizable configuration; lack of lens; a single LCoS (Liquid Crystal on Silicon) modulator; a strong resistance to imperfections and obstructions of the spatial light modulator like dead pixels, dust, mud, fingerprints etc.; simple calculations based on Fast Fourier Transform (FFT) easily processed in real time mode with GPU (Graphic Programming).

Metric freeness and projectivity for classical and quantum normed modules

DOE Office of Scientific and Technical Information (OSTI.GOV)

Helemskii, A Ya

2013-07-31

In functional analysis, there are several diverse approaches to the notion of projective module. We show that a certain general categorical scheme contains all basic versions as special cases. In this scheme, the notion of free object comes to the foreground, and, in the best categories, projective objects are precisely retracts of free ones. We are especially interested in the so-called metric version of projectivity and characterize the metrically free classical and quantum (= operator) normed modules. Informally speaking, so-called extremal projectivity, which was known earlier, is interpreted as a kind of 'asymptotical metric projectivity'. In addition, we answer themore » following specific question in the geometry of normed spaces: what is the structure of metrically projective modules in the simplest case of normed spaces? We prove that metrically projective normed spaces are precisely the subspaces of l{sub 1}(M) (where M is a set) that are denoted by l{sub 1}{sup 0}(M) and consist of finitely supported functions. Thus, in this case, projectivity coincides with freeness. Bibliography: 28 titles.« less

Gravitational self-interactions of a degenerate quantum scalar field

NASA Astrophysics Data System (ADS)

Chakrabarty, Sankha S.; Enomoto, Seishi; Han, Yaqi; Sikivie, Pierre; Todarello, Elisa M.

2018-02-01

We develop a formalism to help calculate in quantum field theory the departures from the description of a system by classical field equations. We apply the formalism to a homogeneous condensate with attractive contact interactions and to a homogeneous self-gravitating condensate in critical expansion. In their classical descriptions, such condensates persist forever. We show that in their quantum description, parametric resonance causes quanta to jump in pairs out of the condensate into all modes with wave vector less than some critical value. We calculate, in each case, the time scale over which the homogeneous condensate is depleted and after which a classical description is invalid. We argue that the duration of classicality of inhomogeneous condensates is shorter than that of homogeneous condensates.

Class II HLA interactions modulate genetic risk for multiple sclerosis

PubMed Central

Dilthey, Alexander T; Xifara, Dionysia K; Ban, Maria; Shah, Tejas S; Patsopoulos, Nikolaos A; Alfredsson, Lars; Anderson, Carl A; Attfield, Katherine E; Baranzini, Sergio E; Barrett, Jeffrey; Binder, Thomas M C; Booth, David; Buck, Dorothea; Celius, Elisabeth G; Cotsapas, Chris; D’Alfonso, Sandra; Dendrou, Calliope A; Donnelly, Peter; Dubois, Bénédicte; Fontaine, Bertrand; Fugger, Lars; Goris, An; Gourraud, Pierre-Antoine; Graetz, Christiane; Hemmer, Bernhard; Hillert, Jan; Kockum, Ingrid; Leslie, Stephen; Lill, Christina M; Martinelli-Boneschi, Filippo; Oksenberg, Jorge R; Olsson, Tomas; Oturai, Annette; Saarela, Janna; Søndergaard, Helle Bach; Spurkland, Anne; Taylor, Bruce; Winkelmann, Juliane; Zipp, Frauke; Haines, Jonathan L; Pericak-Vance, Margaret A; Spencer, Chris C A; Stewart, Graeme; Hafler, David A; Ivinson, Adrian J; Harbo, Hanne F; Hauser, Stephen L; De Jager, Philip L; Compston, Alastair; McCauley, Jacob L; Sawcer, Stephen; McVean, Gil

2016-01-01

Association studies have greatly refined the understanding of how variation within the human leukocyte antigen (HLA) genes influences risk of multiple sclerosis. However, the extent to which major effects are modulated by interactions is poorly characterized. We analyzed high-density SNP data on 17,465 cases and 30,385 controls from 11 cohorts of European ancestry, in combination with imputation of classical HLA alleles, to build a high-resolution map of HLA genetic risk and assess the evidence for interactions involving classical HLA alleles. Among new and previously identified class II risk alleles (HLA-DRB1*15:01, HLA-DRB1*13:03, HLA-DRB1*03:01, HLA-DRB1*08:01 and HLA-DQB1*03:02) and class I protective alleles (HLA-A*02:01, HLA-B*44:02, HLA-B*38:01 and HLA-B*55:01), we find evidence for two interactions involving pairs of class II alleles: HLA-DQA1*01:01–HLA-DRB1*15:01 and HLA-DQB1*03:01–HLA-DQB1*03:02. We find no evidence for interactions between classical HLA alleles and non-HLA risk-associated variants and estimate a minimal effect of polygenic epistasis in modulating major risk alleles. PMID:26343388

Tree-level correlations in the strong field regime

NASA Astrophysics Data System (ADS)

Gelis, François

2017-09-01

We consider the correlation function of an arbitrary number of local observables in quantum field theory, in situations where the field amplitude is large. Using a quasi-classical approximation (valid for a highly occupied initial mixed state, or for a coherent initial state if the classical dynamics has instabilities), we show that at tree level these correlations are dominated by fluctuations at the initial time. We obtain a general expression of the correlation functions in terms of the classical solution of the field equation of motion and its derivatives with respect to its initial conditions, that can be arranged graphically as the sum of labeled trees where the nodes are the individual observables, and the links are pairs of derivatives acting on them. For 3-point (and higher) correlation functions, there are additional tree-level terms beyond the quasi-classical approximation, generated by fluctuations in the bulk.

The state of Hawking radiation is non-classical

NASA Astrophysics Data System (ADS)

Brustein, Ram; Medved, A. J. M.; Zigdon, Yoav

2018-01-01

We show that the state of the Hawking radiation emitted from a large Schwarzschild black hole (BH) deviates significantly from a classical state, in spite of its apparent thermal nature. For this state, the occupation numbers of single modes of massless asymptotic fields, such as photons, gravitons and possibly neutrinos, are small and, as a result, their relative fluctuations are large. The occupation numbers of massive fields are much smaller and suppressed beyond even the expected Boltzmann suppression. It follows that this type of thermal state cannot be viewed as classical or even semiclassical. We substantiate this claim by showing that, in a state with low occupation numbers, physical observables have large quantum fluctuations and, as such, cannot be faithfully described by a mean-field or by a WKB-like semiclassical state. Since the evolution of the BH is unitary, our results imply that the state of the BH interior must also be non-classical when described in terms of the asymptotic fields. We show that such a non-classical interior cannot be described in terms of a semiclassical geometry, even though the average curvature is sub-Planckian.

Quantum to classical transition in quantum field theory

NASA Astrophysics Data System (ADS)

Lombardo, Fernando C.

1998-12-01

We study the quatum to classical transition process in the context of quantum field theory. Extending the influence functional formalism of Feynman and Vernon, we study the decoherence process for self-interacting quantum fields in flat space. We also use this formalism for arbitrary geometries to analyze the quantum to classical transition in quantum gravity. After summarizing the main results known for the quantum Brownian motion, we consider a self-interacting field theory in Minkowski spacetime. We compute a coarse grained effective action by integrating out the field modes with wavelength shorter than a critical value. From this effective action we obtain the evolution equation for the reduced density matrix (master equation). We compute the diffusion coefficients for this equation and analyze the decoherence induced on the long-wavelength modes. We generalize the results to the case of a conformally coupled scalar field in de Sitter spacetime. We show that the decoherence is effective as long as the critical wavelength is taken to be not shorter than the Hubble radius. On the other hand, we study the classical limit for scalar-tensorial models in two dimensions. We consider different couplings between the dilaton and the scalar field. We discuss the Hawking radiation process and, from an exact evaluation of the influence functional, we study the conditions by which decoherence ensures the validity of the semiclassical approximation in cosmological metrics. Finally we consider four dimensional models with massive scalar fields, arbitrary coupled to the geometry. We compute the Einstein-Langevin equations in order to study the effect of the fluctuations induced by the quantum fields on the classical geometry.

Sensitivity optimization of Bell-Bloom magnetometers by manipulation of atomic spin synchronization

NASA Astrophysics Data System (ADS)

Ranjbaran, M.; Tehranchi, M. M.; Hamidi, S. M.; Khalkhali, S. M. H.

2018-05-01

Many efforts have been devoted to the developments of atomic magnetometers for achieving the high sensitivity required in biomagnetic applications. To reach the high sensitivity, many types of atomic magnetometers have been introduced for optimization of the creation and relaxation rates of atomic spin polarization. In this paper, regards to sensitivity optimization techniques in the Mx configuration, we have proposed a novelty approach for synchronization of the spin precession in the Bell-Bloom magnetometers. We have utilized the phenomenological Bloch equations to simulate the spin dynamics when modulation of pumping light and radio frequency magnetic field were both used for atomic spin synchronization. Our results showed that the synchronization process, improved the magnetometer sensitivity respect to the classical configurations.

Experimental contextuality in classical light

NASA Astrophysics Data System (ADS)

Li, Tao; Zeng, Qiang; Song, Xinbing; Zhang, Xiangdong

2017-03-01

The Klyachko, Can, Binicioglu, and Shumovsky (KCBS) inequality is an important contextuality inequality in three-level system, which has been demonstrated experimentally by using quantum states. Using the path and polarization degrees of freedom of classical optics fields, we have constructed the classical trit (cetrit), tested the KCBS inequality and its geometrical form (Wright’s inequality) in this work. The projection measurement has been implemented, the clear violations of the KCBS inequality and its geometrical form have been observed. This means that the contextuality inequality, which is commonly used in test of the conflict between quantum theory and noncontextual realism, may be used as a quantitative tool in classical optical coherence to describe correlation characteristics of the classical fields.

The Classical Vacuum.

ERIC Educational Resources Information Center

Boyer, Timothy H.

1985-01-01

The classical vacuum of physics is not empty, but contains a distinctive pattern of electromagnetic fields. Discovery of the vacuum, thermal spectrum, classical electron theory, zero-point spectrum, and effects of acceleration are discussed. Connection between thermal radiation and the classical vacuum reveals unexpected unity in the laws of…

Neurobiology of Learning and Memory: Modulation and Mechanisms

DTIC Science & Technology

1988-08-01

Behavioral Biology, 6 (1976) pp. 45-62. Birt, D. and Olds, M., Associative response changes in lateral midbrain tegmentum and medial geniculate during...medial geniculate body of the cat during classical conditioning, Society for Neuroscience Abstracts, 6, (1976), p. 435. Ryugo, D.K. and Weinberger, N.M...Differential plasticity of morphologi- cally distinct neuron populations in the medial geniculate body of the cat during classical conditioning

Using biomedical engineering and "hidden capital" to provide educational outreach to disadvantaged populations.

PubMed

Drazan, John F; Scott, John M; Hoke, Jahkeen I; Ledet, Eric H

2014-01-01

A hands-on learning module called "Science of the Slam" is created that taps into the passions and interests of an under-represented group in the fields of Science, Technology, Engineering and Mathematics (STEM). This is achieved by examining the use of the scientific method to quantify the biomechanics of basketball players who are good at performing the slam dunk. Students already have an intrinsic understanding of the biomechanics of basketball however this "hidden capital" has never translated into the underlying STEM concepts. The effectiveness of the program is rooted in the exploitation of "hidden capital" within the field of athletics to inform and enhance athletic performance. This translation of STEM concepts to athletic performance provides a context and a motivation for students to study the STEM fields who are traditionally disengaged from the classic engineering outreach programs. "Science of the Slam" has the potential to serve as a framework for other researchers to engage under-represented groups in novel ways by tapping into shared interests between the researcher and disadvantaged populations.

The effect of electric field geometry on the performance of electromembrane extraction systems: footprints of a third driving force along with migration and diffusion.

PubMed

Moazami, Hamid Reza; Hosseiny Davarani, Saied Saeed; Mohammadi, Jamil; Nojavan, Saeed; Abrari, Masoud

2015-09-03

The distribution of electric field vectors was first calculated for electromembrane extraction (EME) systems in classical and cylindrical electrode geometries. The results showed that supported liquid membrane (SLM) has a general field amplifying effect due to its lower dielectric constant in comparison with aqueous donor/acceptor solutions. The calculated norms of the electric field vector showed that a DC voltage of 50 V can create huge electric field strengths up to 64 kV m(-1) and 111 kV m(-1) in classical and cylindrical geometries respectively. In both cases, the electric field strength reached its peak value on the inner wall of the SLM. In the case of classical geometry, the field strength was a function of the polar position of the SLM whereas the field strength in cylindrical geometry was angularly uniform. In order to investigate the effect of the electrode geometry on the performance of real EME systems, the analysis was carried out in three different geometries including classical, helical and cylindrical arrangements using naproxen and sodium diclofenac as the model analytes. Despite higher field strength and extended cross sectional area, the helical and cylindrical geometries gave lower recoveries with respect to the classical EME. The observed decline of the signal was proved to be against the relations governing migration and diffusion processes, which means that a third driving force is involved in EME. The third driving force is the interaction between the radially inhomogeneous electric field and the analyte in its neutral form. Copyright © 2015 Elsevier B.V. All rights reserved.

On classical and quantum dynamics of tachyon-like fields and their cosmological implications

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dimitrijević, Dragoljub D., E-mail: ddrag@pmf.ni.ac.rs; Djordjević, Goran S., E-mail: ddrag@pmf.ni.ac.rs; Milošević, Milan, E-mail: ddrag@pmf.ni.ac.rs

2014-11-24

We consider a class of tachyon-like potentials, motivated by string theory, D-brane dynamics and inflation theory in the context of classical and quantum mechanics. A formalism for describing dynamics of tachyon fields in spatially homogenous and one-dimensional - classical and quantum mechanical limit is proposed. A few models with concrete potentials are considered. Additionally, possibilities for p-adic and adelic generalization of these models are discussed. Classical actions and corresponding quantum propagators, in the Feynman path integral approach, are calculated in a form invariant on a change of the background number fields, i.e. on both archimedean and nonarchimedean spaces. Looking formore » a quantum origin of inflation, relevance of p-adic and adelic generalizations are briefly discussed.« less

Short distance modification of the quantum virial theorem

NASA Astrophysics Data System (ADS)

Zhao, Qin; Faizal, Mir; Zaz, Zaid

2017-07-01

In this letter, we will analyse the deformation of a semi-classical gravitational system from minimal measurable length scale. In the semi-classical approximation, the gravitational field will be analysed as a classical field, and the matter fields will be treated quantum mechanically. Thus, using this approximation, this system will be represented by a deformation of Schrödinger-Newton equation by the generalised uncertainty principle (GUP). We will analyse the effects of this GUP deformed Schrödinger-Newton equation on the behaviour of such a semi-classical gravitational system. As the quantum mechanical virial theorem can be obtained using the Schrödinger-Newton equation, a short distance modification of the Schrödinger-Newton equation will also result in a short distance modification of the quantum mechanical virial theorem.

Cosine problem in EPRL/FK spinfoam model

NASA Astrophysics Data System (ADS)

Vojinović, Marko

2014-01-01

We calculate the classical limit effective action of the EPRL/FK spinfoam model of quantum gravity coupled to matter fields. By employing the standard QFT background field method adapted to the spinfoam setting, we find that the model has many different classical effective actions. Most notably, these include the ordinary Einstein-Hilbert action coupled to matter, but also an action which describes antigravity. All those multiple classical limits appear as a consequence of the fact that the EPRL/FK vertex amplitude has cosine-like large spin asymptotics. We discuss some possible ways to eliminate the unwanted classical limits.

Violations of a new inequality for classical fields

NASA Technical Reports Server (NTRS)

Franson, J. D.

1992-01-01

Two entangled photons incident upon two distant interferometers can give a coincidence counting rate that depends nonlocally on the sum of the phases of the two interferometers. It has recently been shown that experiments of this kind may violate a simple inequality that must be satisfied by any classical or semi-classical field theory. The inequality provides a graphic illustration of the lack of objective realism of the electric field. The results of a recent experiment which violates this inequality and in which the optical path length between the two interferometers was greater than 100 m are briefly described.

Atomic-Scale Lightning Rod Effect in Plasmonic Picocavities: A Classical View to a Quantum Effect.

PubMed

Urbieta, Mattin; Barbry, Marc; Zhang, Yao; Koval, Peter; Sánchez-Portal, Daniel; Zabala, Nerea; Aizpurua, Javier

2018-01-23

Plasmonic gaps are known to produce nanoscale localization and enhancement of optical fields, providing small effective mode volumes of about a few hundred nm 3 . Atomistic quantum calculations based on time-dependent density functional theory reveal the effect of subnanometric localization of electromagnetic fields due to the presence of atomic-scale features at the interfaces of plasmonic gaps. Using a classical model, we explain this as a nonresonant lightning rod effect at the atomic scale that produces an extra enhancement over that of the plasmonic background. The near-field distribution of atomic-scale hot spots around atomic features is robust against dynamical screening and spill-out effects and follows the potential landscape determined by the electron density around the atomic sites. A detailed comparison of the field distribution around atomic hot spots from full quantum atomistic calculations and from the local classical approach considering the geometrical profile of the atoms' electronic density validates the use of a classical framework to determine the effective mode volume in these extreme subnanometric optical cavities. This finding is of practical importance for the community of surface-enhanced molecular spectroscopy and quantum nanophotonics, as it provides an adequate description of the local electromagnetic fields around atomic-scale features with use of simplified classical methods.

Control and Transfer of Entanglement between Two Atoms Driven by Classical Fields under Dressed-State Representation

NASA Astrophysics Data System (ADS)

Liao, Qing-Hong; Zhang, Qi; Xu, Juan; Yan, Qiu-Rong; Liu, Ye; Chen, An

2016-06-01

We have studied the dynamics and transfer of the entanglement of the two identical atoms simultaneously interacting with vacuum field by employing the dressed-state representation. The two atoms are driven by classical fields. The influence of the initial entanglement degree of two atoms, the coupling strength between the atom and the classical field and the detuning between the atomic transition frequency and the frequency of classical field on the entanglement and atomic linear entropy is discussed. The initial entanglement of the two atoms can be transferred into the entanglement between the atom and cavity field when the dissipation is neglected. The maximally entangled state between the atoms and cavity field can be obtained under some certain conditions. The time of disentanglement of two atoms can be controlled and manipulated by adjusting the detuning and classical driving fields. Moreover, the larger the cavity decay rate is, the more quickly the entanglement of the two atoms decays. Supported by National Natural Science Foundation of China under Grant Nos. 11247213, 61368002, 11304010, 11264030, 61168001, China Postdoctoral Science Foundation under Grant No. 2013M531558, Jiangxi Postdoctoral Research Project under Grant No. 2013KY33, the Natural Science Foundation of Jiangxi Province under Grant No. 20142BAB217001, the Foundation for Young Scientists of Jiangxi Province (Jinggang Star) under Grant No. 20122BCB23002, the Research Foundation of the Education Department of Jiangxi Province under Grant Nos. GJJ13051, GJJ13057, and the Graduate Innovation Special Fund of Nanchang University under Grant No. cx2015137

Cerebellar Norepinephrine Modulates Learning of Delay Classical Eyeblink Conditioning: Evidence for Post-Synaptic Signaling via PKA

ERIC Educational Resources Information Center

Fister, Mathew; Bickford, Paula C.; Cartford, M. Claire; Samec, Amy

2004-01-01

The neurotransmitter norepinephrine (NE) has been shown to modulate cerebellar-dependent learning and memory. Lesions of the nucleus locus coeruleus or systemic blockade of noradrenergic receptors has been shown to delay the acquisition of several cerebellar-dependent learning tasks. To date, no studies have shown a direct involvement of…

Revealing List-Level Control in the Stroop Task by Uncovering Its Benefits and a Cost

ERIC Educational Resources Information Center

Bugg, Julie M.; McDaniel, Mark A.; Scullin, Michael K.; Braver, Todd S.

2011-01-01

Interference is reduced in mostly incongruent relative to mostly congruent lists. Classic accounts of this list-wide proportion congruence effect assume that list-level control processes strategically modulate word reading. Contemporary accounts posit that reliance on the word is modulated poststimulus onset by item-specific information (e.g.,…

Classical and quantum non-linear optical applications using the Mach-Zehnder interferometer

NASA Astrophysics Data System (ADS)

Prescod, Andru

Mach Zehnder (MZ) modulators are widely employed in a variety of applications, such as optical communications, optical imaging, metrology and encryption. In this dissertation, we explore two non-linear MZ applications; one classified as classical and one as quantum, in which the Mach Zehnder interferometer is used. In the first application, a classical non-linear application, we introduce and study a new electro-optic highly linear (e.g., >130 dB) modulator configuration. This modulator makes use of a phase modulator (PM) in one arm of the MZ interferometer (MZI) and a ring resonator (RR) located on the other arm. The modulator performance is obtained through the control of a combination of internal and external parameters. These parameters include the RR-coupling ratio (internal parameter); the RF power split ratio and the RF phase bias (external parameters). Results show the unique and superior features, such as high linearity (SFDR˜133 dB), modulation bandwidth extension (as much as 70%) over the previously proposed and demonstrated Resonator-Assisted Mach Zehnder (RAMZ) design. Furthermore the proposed electro-optic modulator of this dissertation also provides an inherent SFDR compensation capability, even in cases where a significant waveguide optical loss exists. This design also shows potential for increased flexibility, practicality and ease of use. In the second application, a quantum non-linear application, we experimentally demonstrate quantum optical coherence tomography (QOCT) using a type II non-linear crystal (periodically-poled potassium titanyl phosphate (KTiOPO4) or PPKTP). There have been several publications discussing the merits and disadvantages of QOCT compared to OCT and other imaging techniques. First, we discuss the issues and solutions for increasing the efficiency of the quantum entangled photons. Second, we use a free space QOCT experiment to generate a high flux of these quantum entangled photons in two orthogonal polarizations, by parametric down-conversion. Third, by ensuring that these down-converted photons have the same frequency, spatial-temporal mode, and the same polarization when they interfere at a beam splitter, quantum interference should occur. Quantum interference of these entangled photons enables high resolution probing of dispersive samples.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Khrennikov, Andrei

We present fundamentals of a prequantum model with hidden variables of the classical field type. In some sense this is the comeback of classical wave mechanics. Our approach also can be considered as incorporation of quantum mechanics into classical signal theory. All quantum averages (including correlations of entangled systems) can be represented as classical signal averages and correlations.

ASCII Art Synthesis from Natural Photographs.

PubMed

Xu, Xuemiao; Zhong, Linyuan; Xie, Minshan; Liu, Xueting; Qin, Jing; Wong, Tien-Tsin

2017-08-01

While ASCII art is a worldwide popular art form, automatic generating structure-based ASCII art from natural photographs remains challenging. The major challenge lies on extracting the perception-sensitive structure from the natural photographs so that a more concise ASCII art reproduction can be produced based on the structure. However, due to excessive amount of texture in natural photos, extracting perception-sensitive structure is not easy, especially when the structure may be weak and within the texture region. Besides, to fit different target text resolutions, the amount of the extracted structure should also be controllable. To tackle these challenges, we introduce a visual perception mechanism of non-classical receptive field modulation (non-CRF modulation) from physiological findings to this ASCII art application, and propose a new model of non-CRF modulation which can better separate the weak structure from the crowded texture, and also better control the scale of texture suppression. Thanks to our non-CRF model, more sensible ASCII art reproduction can be obtained. In addition, to produce more visually appealing ASCII arts, we propose a novel optimization scheme to obtain the optimal placement of proportional-font characters. We apply our method on a rich variety of images, and visually appealing ASCII art can be obtained in all cases.

Flavonoid nutraceuticals and ionotropic receptors for the inhibitory neurotransmitter GABA.

PubMed

Johnston, Graham A R

2015-10-01

Flavonoids that are found in nutraceuticals have many and varied effects on the activation of ionotropic receptors for GABA, the major inhibitory neurotransmitter in our brains. They can act as positive or negative modulators enhancing or reducing the effect of GABA. They can act as allosteric agonists. They can act to modulate the action of other modulators. There is considerable evidence that these flavonoids are able to enter the brain to influence brain function. They may have a range of effects including relief of anxiety, improvement in cognition, acting as neuroprotectants and as sedatives. All of these effects are sought after in nutraceuticals. A number of studies have likened flavonoids to the widely prescribed benzodiazepines as 'a new family of benzodiazepine receptor ligands'. They are much more than that with many flavonoid actions on ionotropic GABA receptors being insensitive to the classic benzodiazepine antagonist flumazenil and thus independent of the classic benzodiazepine actions. It is time to consider flavonoids in their own right as important modulators of these vital receptors in brain function. Flavonoids are rarely consumed as a single flavonoid except as dietary supplements. The effects of mixtures of flavonoids and other modulators on GABAA receptors need to be more thoroughly investigated. Copyright © 2015 Elsevier Ltd. All rights reserved.

Tachyon field in loop quantum cosmology: Inflation and evolution picture

DOE Office of Scientific and Technical Information (OSTI.GOV)

Xiong Huaui; Zhu Jianyang

2007-04-15

Loop quantum cosmology (LQC) predicts a nonsingular evolution of the universne through a bounce in the high energy region. We show that this is always true in tachyon matter LQC. Differing from the classical Friedman-Robertson-Walker (FRW) cosmology, the super inflation can appear in the tachyon matter LQC; furthermore, the inflation can be extended to the region where classical inflation stops. Using the numerical method, we give an evolution picture of the tachyon field with an exponential potential in the context of LQC. It indicates that the quantum dynamical solutions have the same attractive behavior as the classical solutions do. Themore » whole evolution of the tachyon field is that in the distant past, the tachyon field--being in the contracting cosmology--accelerates to climb up the potential hill with a negative velocity; then at the boundary the tachyon field is bounced into an expanding universe with positive velocity rolling down to the bottom of the potential. In the slow roll limit, we compare the quantum inflation with the classical case in both an analytic and a numerical way.« less

Innovation Online Teaching Module Plus Digital Engineering Kit with Proteus Software through Hybrid Learning Method to Improve Student Skills

NASA Astrophysics Data System (ADS)

Kholis, Nur; Syariffuddien Zuhrie, Muhamad; Rahmadian, Reza

2018-04-01

Demands the competence (competence) needs of the industry today is a competent workforce to the field of work. However, during this lecture material Digital Engineering (Especially Digital Electronics Basics and Digital Circuit Basics) is limited to the delivery of verbal form of lectures (classical method) is dominated by the Lecturer (Teacher Centered). Though the subject of Digital Engineering requires learning tools and is required understanding of electronic circuits, digital electronics and high logic circuits so that learners can apply in the world of work. One effort to make it happen is by creating an online teaching module and educational aids (Kit) with the help of Proteus software that can improve the skills of learners. This study aims to innovate online teaching modules plus kits in Proteus-assisted digital engineering courses through hybrid learning approaches to improve the skills of learners. The process of innovation is done by considering the skills and mastery of the technology of students (students) Department of Electrical Engineering - Faculty of Engineering – Universitas Negeri Surabaya to produce quality graduates Use of online module plus Proteus software assisted kit through hybrid learning approach. In general, aims to obtain adequate results with affordable cost of investment, user friendly, attractive and interactive (easily adapted to the development of Information and Communication Technology). With the right design, implementation and operation, both in the form of software both in the form of Online Teaching Module, offline teaching module, Kit (Educational Viewer), and e-learning learning content (both online and off line), the use of the three tools of the expenditure will be able to adjust the standard needs of Information and Communication Technology world, both nationally and internationally.

Orientation-specific contextual modulation of the fMRI BOLD response to luminance and chromatic gratings in human visual cortex.

PubMed

McDonald, J Scott; Seymour, Kiley J; Schira, Mark M; Spehar, Branka; Clifford, Colin W G

2009-05-01

The responses of orientation-selective neurons in primate visual cortex can be profoundly affected by the presence and orientation of stimuli falling outside the classical receptive field. Our perception of the orientation of a line or grating also depends upon the context in which it is presented. For example, the perceived orientation of a grating embedded in a surround tends to be repelled from the predominant orientation of the surround. Here, we used fMRI to investigate the basis of orientation-specific surround effects in five functionally-defined regions of visual cortex: V1, V2, V3, V3A/LO1 and hV4. Test stimuli were luminance-modulated and isoluminant gratings that produced responses similar in magnitude. Less BOLD activation was evident in response to gratings with parallel versus orthogonal surrounds across all the regions of visual cortex investigated. When an isoluminant test grating was surrounded by a luminance-modulated inducer, the degree of orientation-specific contextual modulation was no larger for extrastriate areas than for V1, suggesting that the observed effects might originate entirely in V1. However, more orientation-specific modulation was evident in extrastriate cortex when both test and inducer were luminance-modulated gratings than when the test was isoluminant; this difference was significant in area V3. We suggest that the pattern of results in extrastriate cortex may reflect a refinement of the orientation-selectivity of surround suppression specific to the colour of the surround or, alternatively, processes underlying the segmentation of test and inducer by spatial phase or orientation when no colour cue is available.

Modulation of Active Site Electronic Structure by the Protein Matrix to Control [NiFe] Hydrogenase Reactivity

DOE Office of Scientific and Technical Information (OSTI.GOV)

Smith, Dayle MA; Raugei, Simone; Squier, Thomas C.

2014-09-30

Control of the reactivity of the nickel center of the [NiFe] hydrogenase and other metalloproteins commonly involves outer coordination sphere ligands that act to modify the geometry and physical properties of the active site metal centers. We carried out a combined set of classical molecular dynamics and quantum/classical mechanics calculations to provide quantitative estimates of how dynamic fluctuations of the active site within the protein matrix modulate the electronic structure at the catalytic center. Specifically we focused on the dynamics of the inner and outer coordination spheres of the cysteinate-bound Ni–Fe cluster in the catalytically active Ni-C state. There aremore » correlated movements of the cysteinate ligands and the surrounding hydrogen-bonding network, which modulate the electron affinity at the active site and the proton affinity of a terminal cysteinate. On the basis of these findings, we hypothesize a coupling between protein dynamics and electron and proton transfer reactions critical to dihydrogen production.« less

Modulation of active site electronic structure by the protein matrix to control [NiFe] hydrogenase reactivity.

PubMed

Smith, Dayle M A; Raugei, Simone; Squier, Thomas C

2014-11-21

Control of the reactivity of the nickel center of the [NiFe] hydrogenase and other metalloproteins commonly involves outer coordination sphere ligands that act to modify the geometry and physical properties of the active site metal centers. We carried out a combined set of classical molecular dynamics and quantum/classical mechanics calculations to provide quantitative estimates of how dynamic fluctuations of the active site within the protein matrix modulate the electronic structure at the catalytic center. Specifically we focused on the dynamics of the inner and outer coordination spheres of the cysteinate-bound Ni-Fe cluster in the catalytically active Ni-C state. There are correlated movements of the cysteinate ligands and the surrounding hydrogen-bonding network, which modulate the electron affinity at the active site and the proton affinity of a terminal cysteinate. On the basis of these findings, we hypothesize a coupling between protein dynamics and electron and proton transfer reactions critical to dihydrogen production.

Drive-induced delocalization in the Aubry-André model

NASA Astrophysics Data System (ADS)

Ray, S.; Ghosh, A.; Sinha, S.

2018-01-01

Motivated by the recent experiment by Bordia et al. [Nat. Phys. 13, 460 (2017), 10.1038/nphys4020], we study the single particle delocalization phenomena of the Aubry-André (AA) model subjected to periodic drives. In two distinct cases we construct an equivalent classical description to illustrate that the drive-induced delocalization phenomena stems from an instability and the onset of chaos in the underlying dynamics. In the first case we analyze the delocalization and the thermalization in a time modulated AA potential with respect to driving frequency and demonstrate that there exists a threshold value of the amplitude of the drive. In the next example, we show that the periodic modulation of the phase of the hopping amplitude induced by a gauge field leads to an unusual effect on delocalization with a nonmonotonic dependence on the driving frequency. Within a window of such a driving frequency a delocalized Floquet band with a mobility edge appears, exhibiting multifractality in the spectrum as well as in the Floquet eigenfunctions. Finally, we explore the effect of interaction and discuss how the results of the present analysis can be tested experimentally.

Cascading and local-field effects in non-linear optics revisited: a quantum-field picture based on exchange of photons.

PubMed

Bennett, Kochise; Mukamel, Shaul

2014-01-28

The semi-classical theory of radiation-matter coupling misses local-field effects that may alter the pulse time-ordering and cascading that leads to the generation of new signals. These are then introduced macroscopically by solving Maxwell's equations. This procedure is convenient and intuitive but ad hoc. We show that both effects emerge naturally by including coupling to quantum modes of the radiation field that are initially in the vacuum state to second order. This approach is systematic and suggests a more general class of corrections that only arise in a QED framework. In the semi-classical theory, which only includes classical field modes, the susceptibility of a collection of N non-interacting molecules is additive and scales as N. Second-order coupling to a vacuum mode generates an effective retarded interaction that leads to cascading and local field effects both of which scale as N(2).

Reward value-based gain control: divisive normalization in parietal cortex.

PubMed

Louie, Kenway; Grattan, Lauren E; Glimcher, Paul W

2011-07-20

The representation of value is a critical component of decision making. Rational choice theory assumes that options are assigned absolute values, independent of the value or existence of other alternatives. However, context-dependent choice behavior in both animals and humans violates this assumption, suggesting that biological decision processes rely on comparative evaluation. Here we show that neurons in the monkey lateral intraparietal cortex encode a relative form of saccadic value, explicitly dependent on the values of the other available alternatives. Analogous to extra-classical receptive field effects in visual cortex, this relative representation incorporates target values outside the response field and is observed in both stimulus-driven activity and baseline firing rates. This context-dependent modulation is precisely described by divisive normalization, indicating that this standard form of sensory gain control may be a general mechanism of cortical computation. Such normalization in decision circuits effectively implements an adaptive gain control for value coding and provides a possible mechanistic basis for behavioral context-dependent violations of rationality.

Gauge interaction as periodicity modulation

NASA Astrophysics Data System (ADS)

Dolce, Donatello

2012-06-01

The paper is devoted to a geometrical interpretation of gauge invariance in terms of the formalism of field theory in compact space-time dimensions (Dolce, 2011) [8]. In this formalism, the kinematic information of an interacting elementary particle is encoded on the relativistic geometrodynamics of the boundary of the theory through local transformations of the underlying space-time coordinates. Therefore gauge interactions are described as invariance of the theory under local deformations of the boundary. The resulting local variations of the field solution are interpreted as internal transformations. The internal symmetries of the gauge theory turn out to be related to corresponding space-time local symmetries. In the approximation of local infinitesimal isometric transformations, Maxwell's kinematics and gauge invariance are inferred directly from the variational principle. Furthermore we explicitly impose periodic conditions at the boundary of the theory as semi-classical quantization condition in order to investigate the quantum behavior of gauge interaction. In the abelian case the result is a remarkable formal correspondence with scalar QED.

Plasmon mass scale and quantum fluctuations of classical fields on a real time lattice

NASA Astrophysics Data System (ADS)

Kurkela, Aleksi; Lappi, Tuomas; Peuron, Jarkko

2018-03-01

Classical real-time lattice simulations play an important role in understanding non-equilibrium phenomena in gauge theories and are used in particular to model the prethermal evolution of heavy-ion collisions. Above the Debye scale the classical Yang-Mills (CYM) theory can be matched smoothly to kinetic theory. First we study the limits of the quasiparticle picture of the CYM fields by determining the plasmon mass of the system using 3 different methods. Then we argue that one needs a numerical calculation of a system of classical gauge fields and small linearized fluctuations, which correspond to quantum fluctuations, in a way that keeps the separation between the two manifest. We demonstrate and test an implementation of an algorithm with the linearized fluctuation showing that the linearization indeed works and that the Gauss's law is conserved.

Relational similarity-based model of data part 1: foundations and query systems

NASA Astrophysics Data System (ADS)

Belohlavek, Radim; Vychodil, Vilem

2017-10-01

We present a general rank-aware model of data which supports handling of similarity in relational databases. The model is based on the assumption that in many cases it is desirable to replace equalities on values in data tables by similarity relations expressing degrees to which the values are similar. In this context, we study various phenomena which emerge in the model, including similarity-based queries and similarity-based data dependencies. Central notion in our model is that of a ranked data table over domains with similarities which is our counterpart to the notion of relation on relation scheme from the classical relational model. Compared to other approaches which cover related problems, we do not propose a similarity-based or ranking module on top of the classical relational model. Instead, we generalize the very core of the model by replacing the classical, two-valued logic upon which the classical model is built by a more general logic involving a scale of truth degrees that, in addition to the classical truth degrees 0 and 1, contains intermediate truth degrees. While the classical truth degrees 0 and 1 represent nonequality and equality of values, and subsequently mismatch and match of queries, the intermediate truth degrees in the new model represent similarity of values and partial match of queries. Moreover, the truth functions of many-valued logical connectives in the new model serve to aggregate degrees of similarity. The presented approach is conceptually clean, logically sound, and retains most properties of the classical model while enabling us to employ new types of queries and data dependencies. Most importantly, similarity is not handled in an ad hoc way or by putting a "similarity module" atop the classical model in our approach. Rather, it is consistently viewed as a notion that generalizes and replaces equality in the very core of the relational model. We present fundamentals of the formal model and two equivalent query systems which are analogues of the classical relational algebra and domain relational calculus with range declarations. In the sequel to this paper, we deal with similarity-based dependencies.

Global inhibition and stimulus competition in the owl optic tectum

PubMed Central

Mysore, Shreesh P.; Asadollahi, Ali; Knudsen, Eric I.

2010-01-01

Stimulus selection for gaze and spatial attention involves competition among stimuli across sensory modalities and across all of space. We demonstrate that such cross-modal, global competition takes place in the intermediate and deep layers of the optic tectum, a structure known to be involved in gaze control and attention. A variety of either visual or auditory stimuli located anywhere outside of a neuron's receptive field (RF) were shown to suppress or completely eliminate responses to a visual stimulus located inside the RF in nitrous oxide sedated owls. The essential mechanism underlying this stimulus competition is global, divisive inhibition. Unlike the effect of the classical inhibitory surround, which decreases with distance from the RF center and shapes neuronal responses to individual stimuli, global inhibition acts across the entirety of space and modulates responses primarily in the context of multiple stimuli. Whereas the source of this global inhibition is as yet unknown, our data indicate that different networks mediate the classical surround and global inhibition. We hypothesize that this global, cross-modal inhibition, which acts automatically in a bottom-up fashion even in sedated animals, is critical to the creation of a map of stimulus salience in the optic tectum. PMID:20130182

Macrophage Heterogeneity and Plasticity: Impact of Macrophage Biomarkers on Atherosclerosis

PubMed Central

Martínez, María Sofía; Palmar, Jim; Bautista, Jordan; Chávez-Castillo, Mervin; Gómez, Alexis; Bermúdez, Valmore

2015-01-01

Cardiovascular disease (CVD) is a global epidemic, currently representing the worldwide leading cause of morbidity and mortality. Atherosclerosis is the fundamental pathophysiologic component of CVD, where the immune system plays an essential role. Monocytes and macrophages are key mediators in this aspect: due to their heterogeneity and plasticity, these cells may act as either pro- or anti-inflammatory mediators. Indeed, monocytes may develop heterogeneous functional phenotypes depending on the predominating pro- or anti-inflammatory microenvironment within the lesion, resulting in classic, intermediate, and non-classic monocytes, each with strikingly differing features. Similarly, macrophages may also adopt heterogeneous profiles being mainly M1 and M2, the former showing a proinflammatory profile while the latter demonstrates anti-inflammatory traits; they are further subdivided in several subtypes with more specialized functions. Furthermore, macrophages may display plasticity by dynamically shifting between phenotypes in response to specific signals. Each of these distinct cell profiles is associated with diverse biomarkers which may be exploited for therapeutic intervention, including IL-10, IL-13, PPAR-γ, LXR, NLRP3 inflammasomes, and microRNAs. Direct modulation of the molecular pathways concerning these potential macrophage-related targets represents a promising field for new therapeutic alternatives in atherosclerosis and CVD. PMID:26491604

Dressing the post-Newtonian two-body problem and classical effective field theory

NASA Astrophysics Data System (ADS)

Kol, Barak; Smolkin, Michael

2009-12-01

We apply a dressed perturbation theory to better organize and economize the computation of high orders of the 2-body effective action of an inspiralling post-Newtonian (PN) gravitating binary. We use the effective field theory approach with the nonrelativistic field decomposition (NRG fields). For that purpose we develop quite generally the dressing theory of a nonlinear classical field theory coupled to pointlike sources. We introduce dressed charges and propagators, but unlike the quantum theory there are no dressed bulk vertices. The dressed quantities are found to obey recursive integral equations which succinctly encode parts of the diagrammatic expansion, and are the classical version of the Schwinger-Dyson equations. Actually, the classical equations are somewhat stronger since they involve only finitely many quantities, unlike the quantum theory. Classical diagrams are shown to factorize exactly when they contain nonlinear worldline vertices, and we classify all the possible topologies of irreducible diagrams for low loop numbers. We apply the dressing program to our post-Newtonian case of interest. The dressed charges consist of the dressed energy-momentum tensor after a nonrelativistic decomposition, and we compute all dressed charges (in the harmonic gauge) appearing up to 2PN in the 2-body effective action (and more). We determine the irreducible skeleton diagrams up to 3PN and we employ the dressed charges to compute several terms beyond 2PN.

A subsequent closed-form description of propagated signaling phenomena in the membrane of an axon

DOE Office of Scientific and Technical Information (OSTI.GOV)

Melendy, Robert F., E-mail: rfmelendy@liberty.edu

2016-05-15

I recently introduced a closed-form description of propagated signaling phenomena in the membrane of an axon [R.F. Melendy, Journal of Applied Physics 118, 244701 (2015)]. Those results demonstrate how intracellular conductance, the thermodynamics of magnetization, and current modulation, function together in generating an action potential in a unified, closed-form description. At present, I report on a subsequent closed-form model that unifies intracellular conductance and the thermodynamics of magnetization, with the membrane electric field, E{sub m}. It’s anticipated this work will compel researchers in biophysics, physical biology, and the computational neurosciences, to probe deeper into the classical and quantum features ofmore » membrane magnetization and signaling, informed by the computational features of this subsequent model.« less

Constrained variational calculus for higher order classical field theories

NASA Astrophysics Data System (ADS)

Campos, Cédric M.; de León, Manuel; Martín de Diego, David

2010-11-01

We develop an intrinsic geometrical setting for higher order constrained field theories. As a main tool we use an appropriate generalization of the classical Skinner-Rusk formalism. Some examples of applications are studied, in particular to the geometrical description of optimal control theory for partial differential equations.

Molecular locks and keys: the role of small molecules in phytohormone research

PubMed Central

Fonseca, Sandra; Rosado, Abel; Vaughan-Hirsch, John; Bishopp, Anthony; Chini, Andrea

2014-01-01

Plant adaptation, growth and development rely on the integration of many environmental and endogenous signals that collectively determine the overall plant phenotypic plasticity. Plant signaling molecules, also known as phytohormones, are fundamental to this process. These molecules act at low concentrations and regulate multiple aspects of plant fitness and development via complex signaling networks. By its nature, phytohormone research lies at the interface between chemistry and biology. Classically, the scientific community has always used synthetic phytohormones and analogs to study hormone functions and responses. However, recent advances in synthetic and combinational chemistry, have allowed a new field, plant chemical biology, to emerge and this has provided a powerful tool with which to study phytohormone function. Plant chemical biology is helping to address some of the most enduring questions in phytohormone research such as: Are there still undiscovered plant hormones? How can we identify novel signaling molecules? How can plants activate specific hormone responses in a tissue-specific manner? How can we modulate hormone responses in one developmental context without inducing detrimental effects on other processes? The chemical genomics approaches rely on the identification of small molecules modulating different biological processes and have recently identified active forms of plant hormones and molecules regulating many aspects of hormone synthesis, transport and response. We envision that the field of chemical genomics will continue to provide novel molecules able to elucidate specific aspects of hormone-mediated mechanisms. In addition, compounds blocking specific responses could uncover how complex biological responses are regulated. As we gain information about such compounds we can design small alterations to the chemical structure to further alter specificity, enhance affinity or modulate the activity of these compounds. PMID:25566283

Expectation maximization for hard X-ray count modulation profiles

NASA Astrophysics Data System (ADS)

Benvenuto, F.; Schwartz, R.; Piana, M.; Massone, A. M.

2013-07-01

Context. This paper is concerned with the image reconstruction problem when the measured data are solar hard X-ray modulation profiles obtained from the Reuven Ramaty High Energy Solar Spectroscopic Imager (RHESSI) instrument. Aims: Our goal is to demonstrate that a statistical iterative method classically applied to the image deconvolution problem is very effective when utilized to analyze count modulation profiles in solar hard X-ray imaging based on rotating modulation collimators. Methods: The algorithm described in this paper solves the maximum likelihood problem iteratively and encodes a positivity constraint into the iterative optimization scheme. The result is therefore a classical expectation maximization method this time applied not to an image deconvolution problem but to image reconstruction from count modulation profiles. The technical reason that makes our implementation particularly effective in this application is the use of a very reliable stopping rule which is able to regularize the solution providing, at the same time, a very satisfactory Cash-statistic (C-statistic). Results: The method is applied to both reproduce synthetic flaring configurations and reconstruct images from experimental data corresponding to three real events. In this second case, the performance of expectation maximization, when compared to Pixon image reconstruction, shows a comparable accuracy and a notably reduced computational burden; when compared to CLEAN, shows a better fidelity with respect to the measurements with a comparable computational effectiveness. Conclusions: If optimally stopped, expectation maximization represents a very reliable method for image reconstruction in the RHESSI context when count modulation profiles are used as input data.

The energy-momentum tensor(s) in classical gauge theories

DOE PAGES

Blaschke, Daniel N.; Gieres, François; Reboud, Méril; ...

2016-07-12

We give an introduction to, and review of, the energy-momentum tensors in classical gauge field theories in Minkowski space, and to some extent also in curved space-time. For the canonical energy-momentum tensor of non-Abelian gauge fields and of matter fields coupled to such fields, we present a new and simple improvement procedure based on gauge invariance for constructing a gauge invariant, symmetric energy-momentum tensor. In conclusion, the relationship with the Einstein-Hilbert tensor following from the coupling to a gravitational field is also discussed.

Linear and angular coherence momenta in the classical second-order coherence theory of vector electromagnetic fields.

PubMed

Wang, Wei; Takeda, Mitsuo

2006-09-01

A new concept of vector and tensor densities is introduced into the general coherence theory of vector electromagnetic fields that is based on energy and energy-flow coherence tensors. Related coherence conservation laws are presented in the form of continuity equations that provide new insights into the propagation of second-order correlation tensors associated with stationary random classical electromagnetic fields.

Magnetostatic communication

DOEpatents

Daily, William D [Livermore, CA

2008-02-26

A system for providing communication of information by modulating a magnetostatic field with a magnetostatic transmitter that modulates said magnetostatic field to contain the information and detecting the information in the modulated field at a distance with a magnetostatic detector that detects the modulated magnetic field containing the information.

Periodically Self Restoring Redundant Systems for VLSI Based Highly Reliable Design,

DTIC Science & Technology

1984-01-01

fault tolerance technique for realizing highly reliable computer systems for critical control applications . However, VL.SI technology has imposed a...operating correctly; failed critical real time control applications . n modules are discarded from the vote. the classical "static" voted redundancy...redundant modules are failure number of InterconnecttIon3. This results In f aree. However, for applications requiring higm modular complexity because

Nonlocal origin of response suppression from stimulation outside the classic receptive field in area 17 of the cat.

PubMed

Brown, H A; Allison, J D; Samonds, J M; Bonds, A B

2003-01-01

A stimulus located outside the classic receptive field (CRF) of a striate cortical neuron can markedly influence its behavior. To study this phenomenon, we recorded from two cortical sites, recorded and peripheral, with separate electrodes in cats anesthetized with Propofol and nitrous oxide. The receptive fields of each site were discrete (2-7.3 deg between centers). A control orientation tuning (OT) curve was measured for a single recorded cell with a drifting grating. The OT curve was then remeasured while stimulating simultaneously the cell's CRF as well as the peripheral site with a stimulus optimized for that location. For 22/60 cells, the peripheral stimulus suppressed the peak response and/or shifted the center of mass of the OT curve. For 19 of these 22 cells, we then reversibly blocked stimulus-driven activity at the peripheral site by iontophoretic application of GABA (0.5 M). For 6/19 cells, the response returned to control levels, implying that for these cells the inhibitory influence arose from the blocked site. The responses of nine cells remained reduced during inactivation of the peripheral site, suggesting that influence was generated outside the region of local block in area 17. This is consistent with earlier findings suggesting that modulatory influences can originate from higher cortical areas. Three cells had mixed results, suggesting multiple origins of influence. The response of each cell returned to suppressed levels after dissipation of the GABA and returned to baseline values when the peripheral stimulus was removed. These findings support a cortical model in which a cell's response is modulated by an inhibitory network originating from beyond the receptive field that supplants convergence of excitatory lateral geniculate neurons. The existence of cells that exhibit no change in peripherally inhibited responses during the GABA application suggests that peripheral influences may arise from outside area 17, presumably from other cortical areas (e.g. area 18).

Thermal radiation transfer calculations in combustion fields using the SLW model coupled with a modified reference approach

NASA Astrophysics Data System (ADS)

Darbandi, Masoud; Abrar, Bagher

2018-01-01

The spectral-line weighted-sum-of-gray-gases (SLW) model is considered as a modern global model, which can be used in predicting the thermal radiation heat transfer within the combustion fields. The past SLW model users have mostly employed the reference approach to calculate the local values of gray gases' absorption coefficient. This classical reference approach assumes that the absorption spectra of gases at different thermodynamic conditions are scalable with the absorption spectrum of gas at a reference thermodynamic state in the domain. However, this assumption cannot be reasonable in combustion fields, where the gas temperature is very different from the reference temperature. Consequently, the results of SLW model incorporated with the classical reference approach, say the classical SLW method, are highly sensitive to the reference temperature magnitude in non-isothermal combustion fields. To lessen this sensitivity, the current work combines the SLW model with a modified reference approach, which is a particular one among the eight possible reference approach forms reported recently by Solovjov, et al. [DOI: 10.1016/j.jqsrt.2017.01.034, 2017]. The combination is called "modified SLW method". This work shows that the modified reference approach can provide more accurate total emissivity calculation than the classical reference approach if it is coupled with the SLW method. This would be particularly helpful for more accurate calculation of radiation transfer in highly non-isothermal combustion fields. To approve this, we use both the classical and modified SLW methods and calculate the radiation transfer in such fields. It is shown that the modified SLW method can almost eliminate the sensitivity of achieved results to the chosen reference temperature in treating highly non-isothermal combustion fields.

Quantum and classical dissipation of charged particles

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ibarra-Sierra, V.G.; Anzaldo-Meneses, A.; Cardoso, J.L.

2013-08-15

A Hamiltonian approach is presented to study the two dimensional motion of damped electric charges in time dependent electromagnetic fields. The classical and the corresponding quantum mechanical problems are solved for particular cases using canonical transformations applied to Hamiltonians for a particle with variable mass. Green’s function is constructed and, from it, the motion of a Gaussian wave packet is studied in detail. -- Highlights: •Hamiltonian of a damped charged particle in time dependent electromagnetic fields. •Exact Green’s function of a charged particle in time dependent electromagnetic fields. •Time evolution of a Gaussian wave packet of a damped charged particle.more » •Classical and quantum dynamics of a damped electric charge.« less

Vaccine Efficacy Against a New Avian Influenza (H9N2) Field Isolate from the Middle East (Serology and Challenge Studies).

PubMed

Gharaibeh, Saad; Amareen, Shadi

2016-05-01

Avian influenza subtype H9N2 is endemic in many countries in the Middle East. The reported prevalence of infection was variable between countries and ranged from 28.7% in Tunisia to 71% in Jordan. Several commercial killed whole-virus vaccine products are used as monovalent or bivalent mixed with Newcastle disease virus. Recently, we have noticed that many of the vaccinated broiler flocks did not show a production advantage over nonvaccinated flocks in the field. A new avian influenza field virus (H9N2) was isolated from these vaccinated and infected broiler flocks in 2013. This virus had 89.1% similarity of its hemagglutinin (HA) gene to the classical virus used for manufacturing the classical vaccine. Inactivated autogenous vaccine was manufactured from this new field isolate to investigate its serological response and protection in specific-pathogen-free (SPF) and breeder-male chickens compared to the classical vaccine. Oropharyngeal virus shedding of vaccinated breeder-male chickens was evaluated at 3, 9, 10, and 14 days postchallenge (DPC). Percentage of chickens shedding the virus at 3 DPC was 64%, 50%, and 64% in the classical vaccine group, autogenous vaccine group, and the control challenged group, respectively. At 7 DPC percentage of virus shedding was 42%, 7%, and 64% in the classical vaccine group, autogenous vaccine group, and the control challenged group, respectively. At 10 DPC only 9% of classical vaccine group was shedding the virus and there was no virus shedding in any of the groups at 14 DPC. There was statistical significance difference (P < 0.05) in shedding only at 7 DPC between the autogenous vaccine group and the other two groups. At 42 days of age (14 DPC), average body weight was 2.720, 2.745, 2.290, and 2.760 kg for the classical vaccine group, autogenous vaccine group, control challenged group, and control unchallenged group, respectively. Only the control challenged group had significantly (P < 0.05) lower average body weight. In another experiment, vaccinated SPF chicks had hemagglutination inhibition (HI) geometric mean titers (GMTs), with classical antigen, of 8.7 and 3.1 log 2 for classical and autogenous vaccine groups, respectively. When the autogenous antigen was used for HI, GMTs were 6.0 and 8.1 log 2, respectively. Both vaccines protected against body weight suppression after challenge. However, autogenous vaccine elicited significantly higher HI titer and reduced viral shedding at 7 DPC. In conclusion, it is important to revise the vaccine virus strains used in each region to protect against and control infection from new field strains. Further field experiments are needed to demonstrate the efficacy of new vaccines under field conditions.

An Imperfect Dopaminergic Error Signal Can Drive Temporal-Difference Learning

PubMed Central

Potjans, Wiebke; Diesmann, Markus; Morrison, Abigail

2011-01-01

An open problem in the field of computational neuroscience is how to link synaptic plasticity to system-level learning. A promising framework in this context is temporal-difference (TD) learning. Experimental evidence that supports the hypothesis that the mammalian brain performs temporal-difference learning includes the resemblance of the phasic activity of the midbrain dopaminergic neurons to the TD error and the discovery that cortico-striatal synaptic plasticity is modulated by dopamine. However, as the phasic dopaminergic signal does not reproduce all the properties of the theoretical TD error, it is unclear whether it is capable of driving behavior adaptation in complex tasks. Here, we present a spiking temporal-difference learning model based on the actor-critic architecture. The model dynamically generates a dopaminergic signal with realistic firing rates and exploits this signal to modulate the plasticity of synapses as a third factor. The predictions of our proposed plasticity dynamics are in good agreement with experimental results with respect to dopamine, pre- and post-synaptic activity. An analytical mapping from the parameters of our proposed plasticity dynamics to those of the classical discrete-time TD algorithm reveals that the biological constraints of the dopaminergic signal entail a modified TD algorithm with self-adapting learning parameters and an adapting offset. We show that the neuronal network is able to learn a task with sparse positive rewards as fast as the corresponding classical discrete-time TD algorithm. However, the performance of the neuronal network is impaired with respect to the traditional algorithm on a task with both positive and negative rewards and breaks down entirely on a task with purely negative rewards. Our model demonstrates that the asymmetry of a realistic dopaminergic signal enables TD learning when learning is driven by positive rewards but not when driven by negative rewards. PMID:21589888

Estrogen receptor 1 modulates circadian rhythms in adult female mice.

PubMed

Blattner, Margaret S; Mahoney, Megan M

2014-06-01

Estradiol influences the level and distribution of daily activity, the duration of the free-running period, and the behavioral phase response to light pulses. However, the mechanisms by which estradiol regulates daily and circadian rhythms are not fully understood. We tested the hypothesis that estrogens modulate daily activity patterns via both classical and "non-classical" actions at the estrogen receptor subtype 1 (ESR1). We used female transgenic mice with mutations in their estrogen response pathways; ESR1 knock-out (ERKO) mice and "non-classical" estrogen receptor knock-in (NERKI) mice. NERKI mice have an ESR1 receptor with a mutation in the estrogen-response-element binding domain, allowing only actions via "non-classical" genomic and second messenger pathways. Ovariectomized female NERKI, ERKO, and wildtype (WT) mice were given a subcutaneous capsule with low- or high-dose estradiol and compared with counterparts with no hormone replacement. We measured wheel-running activity in a light:dark cycle and constant darkness, and the behavioral phase response to light pulses given at different points during the subjective day and night. Estradiol increased average daily wheel-running, consolidated activity to the dark phase, and shortened the endogenous period in WT, but not NERKI and ERKO mice. The timing of activity onset during entrainment was advanced in all estradiol-treated animals regardless of genotype suggesting an ESR1-independent mechanism. We propose that estradiol modifies period, activity level, and distribution of activity via classical actions of ESR1 whereas an ESR1 independent mechanism regulates the phase of rhythms.

The Classical Version of Stokes' Theorem Revisited

ERIC Educational Resources Information Center

Markvorsen, Steen

2008-01-01

Using only fairly simple and elementary considerations--essentially from first year undergraduate mathematics--we show how the classical Stokes' theorem for any given surface and vector field in R[superscript 3] follows from an application of Gauss' divergence theorem to a suitable modification of the vector field in a tubular shell around the…

Analogy between electromagnetic potentials and wave-like dynamic variables with connections to quantum theory

NASA Astrophysics Data System (ADS)

Yang, Chen

2018-05-01

The transitions from classical theories to quantum theories have attracted many interests. This paper demonstrates the analogy between the electromagnetic potentials and wave-like dynamic variables with their connections to quantum theory for audiences at advanced undergraduate level and above. In the first part, the counterpart relations in the classical electrodynamics (e.g. gauge transform and Lorenz condition) and classical mechanics (e.g. Legendre transform and free particle condition) are presented. These relations lead to similar governing equations of the field variables and dynamic variables. The Lorenz gauge, scalar potential and vector potential manifest a one-to-one similarity to the action, Hamiltonian and momentum, respectively. In the second part, the connections between the classical pictures of electromagnetic field and particle to quantum picture are presented. By characterising the states of electromagnetic field and particle via their (corresponding) variables, their evolution pictures manifest the same algebraic structure (isomorphic). Subsequently, pictures of the electromagnetic field and particle are compared to the quantum picture and their interconnections are given. A brief summary of the obtained results are presented at the end of the paper.

Orbital eccentricity in classical novae

NASA Technical Reports Server (NTRS)

Edwards, D. A.; Pringle, J. E.

1987-01-01

The effect on the orbital parameters of a classical nova of the ejection of mass during the nova explosion is considered. The most easily observable consequence is the generation of a small eccentricity in the orbit which leads to a luminosity modulation at a period just longer than the orbital period. Observation of such an effect would have implications not just for interpreting the dynamics of the explosion but also for measuring the secular effect of tidal interaction after the outburst.

Classical confinement and outward convection of impurity ions in the MST RFP

NASA Astrophysics Data System (ADS)

Kumar, S. T. A.; Den Hartog, D. J.; Mirnov, V. V.; Caspary, K. J.; Magee, R. M.; Brower, D. L.; Chapman, B. E.; Craig, D.; Ding, W. X.; Eilerman, S.; Fiksel, G.; Lin, L.; Nornberg, M.; Parke, E.; Reusch, J. A.; Sarff, J. S.

2012-05-01

Impurity ion dynamics measured with simultaneously high spatial and temporal resolution reveal classical ion transport in the reversed-field pinch. The boron, carbon, oxygen, and aluminum impurity ion density profiles are obtained in the Madison Symmetric Torus [R. N. Dexter et al., Fusion Technol. 19, 131 (1991)] using a fast, active charge-exchange-recombination-spectroscopy diagnostic. Measurements are made during improved-confinement plasmas obtained using inductive control of tearing instability to mitigate stochastic transport. At the onset of the transition to improved confinement, the impurity ion density profile becomes hollow, with a slow decay in the core region concurrent with an increase in the outer region, implying an outward convection of impurities. Impurity transport from Coulomb collisions in the reversed-field pinch is classical for all collisionality regimes, and analysis shows that the observed hollow profile and outward convection can be explained by the classical temperature screening mechanism. The profile agrees well with classical expectations. Experiments performed with impurity pellet injection provide further evidence for classical impurity ion confinement.

Effective dynamics of a classical point charge

DOE Office of Scientific and Technical Information (OSTI.GOV)

Polonyi, Janos, E-mail: polonyi@iphc.cnrs.fr

2014-03-15

The effective Lagrangian of a point charge is derived by eliminating the electromagnetic field within the framework of the classical closed time path formalism. The short distance singularity of the electromagnetic field is regulated by an UV cutoff. The Abraham–Lorentz force is recovered and its similarity to quantum anomalies is underlined. The full cutoff-dependent linearized equation of motion is obtained, no runaway trajectories are found but the effective dynamics shows acausality if the cutoff is beyond the classical charge radius. The strength of the radiation reaction force displays a pole in its cutoff-dependence in a manner reminiscent of the Landau-polemore » of perturbative QED. Similarity between the dynamical breakdown of the time reversal invariance and dynamical symmetry breaking is pointed out. -- Highlights: •Extension of the classical action principle for dissipative systems. •New derivation of the Abraham–Lorentz force for a point charge. •Absence of a runaway solution of the Abraham–Lorentz force. •Acausality in classical electrodynamics. •Renormalization of classical electrodynamics of point charges.« less

SU-E-T-97: Dependence Of Optically Stimulated Luminescent Dosimeter (OSLD) Out Of Field Response On Volumetric Modulated Arc Therapy (VMAT) Field Modulation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ware, S; Clouser, E

2014-06-01

Purpose: To determine the out of field response of Microstar ii OSLDs as a function of field modulation and distance in VMAT plan delivery. This work has potential application in fetal dose monitoring or measurements on cardiac pacemakers Methods: VMAT plans were created in Eclipse and optimized to varying degrees of modulation. Three plans were chosen to represent low, medium and high degrees of modulation (modulation factors as defined by MU/cGy). Plans were delivered to slabs of solid water with dimensions 60cm length, 30cm width, and 10cm height. For each modulation factor, 2 OSLDs were placed at 1cm depth withmore » out of field distances of 1, 2, 3, 5, 8 and 10cm and the plan delivered isocentrically to a depth of 5cm. This technique was repeated for a Farmer Chamber by incrementing the table by the appropriate distance. The charge readings for the Farmer Chamber were converted to dose and the ratios taken as functions of modulation factors and distances out of field Results: Examination of the results as a function of out of field distance shows a trend of increasing OSLD/Farmer Chamber ratios for all modulation factors. The slopes appear to be roughly equivalent for all modulation factors investigated. Results as a function of modulation showed a downward trend for all out of field distances, with the greatest differences seen at 5cm and 8cm Conclusion: This study demonstrates that the response of OSLD dosimeters change as a function of out of field distance and modulation. The differences seen are within the stated accuracy of the system for the out of field distances and modulations investigated. Additional investigation is warranted to see if the OSLD response changes appreciably with longer out of field distances or wider ranges of modulation.« less

Nutrigenomics and nutrigenetics: the emerging faces of nutrition.

PubMed

Mutch, David M; Wahli, Walter; Williamson, Gary

2005-10-01

The recognition that nutrients have the ability to interact and modulate molecular mechanisms underlying an organism's physiological functions has prompted a revolution in the field of nutrition. Performing population-scaled epidemiological studies in the absence of genetic knowledge may result in erroneous scientific conclusions and misinformed nutritional recommendations. To circumvent such issues and more comprehensively probe the relationship between genes and diet, the field of nutrition has begun to capitalize on both the technologies and supporting analytical software brought forth in the post-genomic era. The creation of nutrigenomics and nutrigenetics, two fields with distinct approaches to elucidate the interaction between diet and genes but with a common ultimate goal to optimize health through the personalization of diet, provide powerful approaches to unravel the complex relationship between nutritional molecules, genetic polymorphisms, and the biological system as a whole. Reluctance to embrace these new fields exists primarily due to the fear that producing overwhelming quantities of biological data within the confines of a single study will submerge the original query; however, the current review aims to position nutrigenomics and nutrigenetics as the emerging faces of nutrition that, when considered with more classical approaches, will provide the necessary stepping stones to achieve the ambitious goal of optimizing an individual's health via nutritional intervention.

A large-alphabet three-party quantum key distribution protocol based on orbital and spin angular momenta hybrid entanglement

NASA Astrophysics Data System (ADS)

Lai, Hong; Luo, Mingxing; Zhang, Jun; Pieprzyk, Josef; Pan, Lei; Orgun, Mehmet A.

2018-07-01

The orthogonality of the orbital angular momentum (OAM) eigenstates enables a single photon carry an arbitrary number of bits. Moreover, additional degrees of freedom (DOFs) of OAM can span a high-dimensional Hilbert space, which could greatly increase information capacity and security. Moreover, the use of the spin angular momentum-OAM hybrid entangled state can increase Shannon dimensionality, because photons can be hybrid entangled in multiple DOFs. Based on these observations, we develop a hybrid entanglement quantum key distribution (QKD) protocol to achieve three-party quantum key distribution without classical message exchanges. In our proposed protocol, a communicating party uses a spatial light modulator (SLM) and a specific phase hologram to modulate photons' OAM state. Similarly, the other communicating parties use their SLMs and the fixed different phase holograms to modulate the OAM entangled photon pairs, producing the shared key among the parties Alice, Bob and Charlie without classical message exchanges. More importantly, when the same operation is repeated for every party, our protocol could be extended to a multiple-party QKD protocol.

A simple example of a classical gauge transformation

NASA Technical Reports Server (NTRS)

Whitten, R. C.

1983-01-01

Attention is given to the manner in which the interaction of a gravitational field with a diffusing gas is induced by a gauge transformation. Since the gas can be thought of as a field, the diffusion process may be represented by a Lagrangian density with the symmetry property of invariance under translation. While this property is lost when the field interacts with a static gravitational field, it is formally restored when an appropriate gauge transformation is performed. This ascription of field properties to a gas offers an illuminating illustration of the coupling of matter to a gauge field within the context of classical mechanics.

Method of optical coherence tomography with parallel depth-resolved signal reception and fibre-optic phase modulators

DOE Office of Scientific and Technical Information (OSTI.GOV)

Morozov, A N; Turchin, I V

2013-12-31

The method of optical coherence tomography with the scheme of parallel reception of the interference signal (P-OCT) is developed on the basis of spatial paralleling of the reference wave by means of a phase diffraction grating producing the appropriate time delay in the Mach–Zehnder interferometer. The absence of mechanical variation of the optical path difference in the interferometer essentially reduces the time required for 2D imaging of the object internal structure, as compared to the classical OCT that uses the time-domain method of the image construction, the sensitivity and the dynamic range being comparable in both approaches. For the resultingmore » field of the interfering object and reference waves an analytical expression is derived that allows the calculation of the autocorrelation function in the plane of photodetectors. For the first time a method of linear phase modulation by 2π is proposed for P-OCT systems, which allows the use of compact high-frequency (a few hundred kHz) piezoelectric cell-based modulators. For the demonstration of the P-OCT method an experimental setup was created, using which the images of the inner structure of biological objects at the depth up to 1 mm with the axial spatial resolution of 12 μm were obtained. (optical coherence tomography)« less

Koopman-von Neumann formulation of classical Yang-Mills theories: I

NASA Astrophysics Data System (ADS)

Carta, P.; Gozzi, E.; Mauro, D.

2006-03-01

In this paper we present the Koopman-von Neumann (KvN) formulation of classical non-Abelian gauge field theories. In particular we shall explore the functional (or classical path integral) counterpart of the KvN method. In the quantum path integral quantization of Yang-Mills theories concepts like gauge-fixing and Faddeev-Popov determinant appear in a quite natural way. We will prove that these same objects are needed also in this classical path integral formulation for Yang-Mills theories. We shall also explore the classical path integral counterpart of the BFV formalism and build all the associated universal and gauge charges. These last are quite different from the analog quantum ones and we shall show the relation between the two. This paper lays the foundation of this formalism which, due to the many auxiliary fields present, is rather heavy. Applications to specific topics outlined in the paper will appear in later publications.

Simulations of "tunnelling of the 3rd kind"

NASA Astrophysics Data System (ADS)

Mou, Zong-Gang; Saffin, Paul M.; Tognarelli, Paul; Tranberg, Anders

2017-07-01

We consider the phenomenon of "tunnelling of the 3rd kind" [1], whereby a magnetic field may traverse a classically impenetrable barrier by pair creation of unimpeded quantum fermions. These propagate through the barrier and generate a magnetic field on the other side. We study this numerically using quantum fermions coupled to a classical Higgs-gauge system, where we set up a magnetic field outside a box shielded by two superconducting barriers. We examine the magnitude of the internal magnetic field, and find agreement with existing perturbative results within a factor of two.

Apparent Paradoxes in Classical Electrodynamics: A Fluid Medium in an Electromagnetic Field

ERIC Educational Resources Information Center

Kholmetskii, A. L.; Yarman, T.

2008-01-01

In this paper we analyse a number of teaching paradoxes of classical electrodynamics, dealing with the relativistic transformation of energy and momentum for a fluid medium in an external electromagnetic field. In particular, we consider a moving parallel plate charged capacitor, where the electric attraction of its plates is balanced by the…

The evolving Planck mass in classically scale-invariant theories

NASA Astrophysics Data System (ADS)

Kannike, K.; Raidal, M.; Spethmann, C.; Veermäe, H.

2017-04-01

We consider classically scale-invariant theories with non-minimally coupled scalar fields, where the Planck mass and the hierarchy of physical scales are dynamically generated. The classical theories possess a fixed point, where scale invariance is spontaneously broken. In these theories, however, the Planck mass becomes unstable in the presence of explicit sources of scale invariance breaking, such as non-relativistic matter and cosmological constant terms. We quantify the constraints on such classical models from Big Bang Nucleosynthesis that lead to an upper bound on the non-minimal coupling and require trans-Planckian field values. We show that quantum corrections to the scalar potential can stabilise the fixed point close to the minimum of the Coleman-Weinberg potential. The time-averaged motion of the evolving fixed point is strongly suppressed, thus the limits on the evolving gravitational constant from Big Bang Nucleosynthesis and other measurements do not presently constrain this class of theories. Field oscillations around the fixed point, if not damped, contribute to the dark matter density of the Universe.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shore, B.W.; Knight, P.L.

The Jaynes-Cummings Model (JCM), a soluble fully quantum mechanical model of an atom in a field, was first used (in 1963) to examine the classical aspects of spontaneous emission and to reveal the existence of Rabi oscillations in atomic excitation probability for fields with sharply defined energy (or photon number). For fields having a statistical distributions of photon numbers the oscillations collapse to an expected steady value. In 1980 it was discovered that with appropriate initial conditions (e.g. a near-classical field), the Rabi oscillations would eventually revive -- only to collapse and revive repeatedly in a complicated pattern. The existencemore » of these revivals, present in the analytic solutions of the JCM, provided direct evidence for discreteness of field excitation (photons) and hence for the truly quantum nature of radiation. Subsequent study revealed further nonclassical properties of the JCM field, such as a tendency of the photons to antibunch. Within the last two years it has been found that during the quiescent intervals of collapsed Rabi oscillations the atom and field exist in a macroscopic superposition state (a Schroedinger cat). This discovery offers the opportunity to use the JCM to elucidate the basic properties of quantum correlation (entanglement) and to explore still further the relationship between classical and quantum physics. In tribute to E. D. Jaynes, who first recognized the importance of the JCM for clarifying the differences and similarities between quantum and classical physics, we here present an overview of the theory of the JCM and some of the many remarkable discoveries about it.« less

Reproducing Quantum Probability Distributions at the Speed of Classical Dynamics: A New Approach for Developing Force-Field Functors.

PubMed

Sundar, Vikram; Gelbwaser-Klimovsky, David; Aspuru-Guzik, Alán

2018-04-05

Modeling nuclear quantum effects is required for accurate molecular dynamics (MD) simulations of molecules. The community has paid special attention to water and other biomolecules that show hydrogen bonding. Standard methods of modeling nuclear quantum effects like Ring Polymer Molecular Dynamics (RPMD) are computationally costlier than running classical trajectories. A force-field functor (FFF) is an alternative method that computes an effective force field that replicates quantum properties of the original force field. In this work, we propose an efficient method of computing FFF using the Wigner-Kirkwood expansion. As a test case, we calculate a range of thermodynamic properties of Neon, obtaining the same level of accuracy as RPMD, but with the shorter runtime of classical simulations. By modifying existing MD programs, the proposed method could be used in the future to increase the efficiency and accuracy of MD simulations involving water and proteins.

Air-Coupled Vibrometry

NASA Astrophysics Data System (ADS)

Döring, D.; Solodov, I.; Busse, G.

Sound and ultrasound in air are the products of a multitude of different processes and thus can be favorable or undesirable phenomena. Development of experimental tools for non-invasive measurements and imaging of airborne sound fields is of importance for linear and nonlinear nondestructive material testing as well as noise control in industrial or civil engineering applications. One possible solution is based on acousto-optic interaction, like light diffraction imaging. The diffraction approach usually requires a sophisticated setup with fine optical alignment barely applicable in industrial environment. This paper focuses on the application of the robust experimental tool of scanning laser vibrometry, which utilizes commercial off-the-shelf equipment. The imaging technique of air-coupled vibrometry (ACV) is based on the modulation of the optical path length by the acoustic pressure of the sound wave. The theoretical considerations focus on the analysis of acousto-optical phase modulation. The sensitivity of the ACV in detecting vibration velocity was estimated as ~1 mm/s. The ACV applications to imaging of linear airborne fields are demonstrated for leaky wave propagation and measurements of ultrasonic air-coupled transducers. For higher-intensity ultrasound, the classical nonlinear effect of the second harmonic generation was measured in air. Another nonlinear application includes a direct observation of the nonlinear air-coupled emission (NACE) from the damaged areas in solid materials. The source of the NACE is shown to be strongly localized around the damage and proposed as a nonlinear "tag" to discern and image the defects.

Egocentric and allocentric representations in auditory cortex

PubMed Central

Brimijoin, W. Owen; Bizley, Jennifer K.

2017-01-01

A key function of the brain is to provide a stable representation of an object’s location in the world. In hearing, sound azimuth and elevation are encoded by neurons throughout the auditory system, and auditory cortex is necessary for sound localization. However, the coordinate frame in which neurons represent sound space remains undefined: classical spatial receptive fields in head-fixed subjects can be explained either by sensitivity to sound source location relative to the head (egocentric) or relative to the world (allocentric encoding). This coordinate frame ambiguity can be resolved by studying freely moving subjects; here we recorded spatial receptive fields in the auditory cortex of freely moving ferrets. We found that most spatially tuned neurons represented sound source location relative to the head across changes in head position and direction. In addition, we also recorded a small number of neurons in which sound location was represented in a world-centered coordinate frame. We used measurements of spatial tuning across changes in head position and direction to explore the influence of sound source distance and speed of head movement on auditory cortical activity and spatial tuning. Modulation depth of spatial tuning increased with distance for egocentric but not allocentric units, whereas, for both populations, modulation was stronger at faster movement speeds. Our findings suggest that early auditory cortex primarily represents sound source location relative to ourselves but that a minority of cells can represent sound location in the world independent of our own position. PMID:28617796

Digital off-axis holographic interferometry with simulated wavefront.

PubMed

Belashov, A V; Petrov, N V; Semenova, I V

2014-11-17

The paper presents a novel algorithm based on digital holographic interferometry and being promising for evaluation of phase variations from highly noisy or modulated by speckle-structures digital holograms. The suggested algorithm simulates an interferogram in finite width fringes, by analogy with classical double exposure holographic interferometry. Thus obtained interferogram is then processed as a digital hologram. The advantages of the suggested approach are demonstrated in numerical experiments on calculations of differences in phase distributions of wave fronts modulated by speckle structure, as well as in a physical experiment on the analysis of laser-induced heating dynamics of an aqueous solution of a photosensitizer. It is shown that owing to the inherent capability of the approach to perform adjustable smoothing of compared wave fronts, the resulting difference undergoes noise filtering. This capability of adjustable smoothing may be used to minimize losses in spatial resolution. Since the method allows to vary an observation angle of compared wave fields, an opportunity to compensate misalignment of optical axes of these wave fronts arises. This feature can be required, for example, when using two different setups in comparative digital holography or for compensation of recording system displacements during a set of exposures in studies of dynamic processes.

Pharmacological Modulation of Diacylglycerol-Sensitive TRPC3/6/7 Channels

PubMed Central

Harteneck, Christian; Gollasch, Maik

2011-01-01

Members of the classic type of transient receptor potential channels (TRPC) represent important molecules involved in hormonal signal transduction. TRPC3/6/7 channels are of particular interest as they are components of phospholipase C driven signalling pathways. Upon receptor-activation, G-protein-mediated stimulation of phospholipase C results in breakdown of phosphatidylinositides leading to increased intracellular diacylglycerol and inositol-trisphosphate levels. Diacylglycerol activates protein kinase C, but more interestingly diacylglycerol directly activates TRPC2/3/6/7 channels. Molecular cloning, expression and characterization of TRP channels enabled reassignment of traditional inhibitors of receptor-dependent calcium entry such as SKF-96365 and 2-APB as blockers of TRPC3/6/7 and several members of non-classic TRP channels. Furthermore, several enzyme inhibitors have also been identified as TRP channel blockers, such as ACA, a phospholipase A2 inhibitor, and W-7, a calmodulin antagonist. Finally, the naturally occurring secondary plant compound hyperforin has been identified as TRPC6-selective drug, providing an exciting proof of concept that it is possible to generate TRPC-selective channel modulators. The description of Pyr3 as the first TRPC3-selective inhibitor shows that not only nature but also man is able to generate TRP-selective modulators. The review sheds lights on the current knowledge and historical development of pharmacological modulators of TRPC3/6/7. Our analysis indicates that Pyr3 and hyperforin provide promising core structures for the development of new, selective and more potent modulators of TRPC3/6/7 activity. PMID:20932261

Enhanced modulation rates via field modulation in spin torque nano-oscillators

DOE Office of Scientific and Technical Information (OSTI.GOV)

Purbawati, A.; Garcia-Sanchez, F.; Buda-Prejbeanu, L. D.

Spin Transfer Nano-Oscillators (STNOs) are promising candidates for telecommunications applications due to their frequency tuning capabilities via either a dc current or an applied field. This frequency tuning is of interest for Frequency Shift Keying concepts to be used in wireless communication schemes or in read head applications. For these technological applications, one important parameter is the characterization of the maximum achievable rate at which an STNO can respond to a modulating signal, such as current or field. Previous studies of in-plane magnetized STNOs on frequency modulation via an rf current revealed that the maximum achievable rate is limited bymore » the amplitude relaxation rate Γ{sub p}, which gives the time scale over which amplitude fluctuations are damped out. This might be a limitation for applications. Here, we demonstrate via numerical simulation that application of an additional rf field is an alternative way for modulation of the in-plane magnetized STNO configuration, which has the advantage that frequency modulation is not limited by the amplitude relaxation rate, so that higher modulation rates above GHz are achievable. This occurs when the modulating rf field is oriented along the easy axis (longitudinal rf field). Tilting the direction of the modulating rf field in-plane and perpendicularly with respect to the easy axis (transverse rf field), the modulation is again limited by the amplitude relaxation rate similar to the response observed in current modulation.« less

Quark and gluon production from a boost-invariantly expanding color electric field

NASA Astrophysics Data System (ADS)

Taya, Hidetoshi

2017-07-01

Particle production from an expanding classical color electromagnetic field is extensively studied, motivated by the early stage dynamics of ultrarelativistic heavy ion collisions. We develop a formalism at one-loop order to compute the particle spectra by canonically quantizing quark, gluon, and ghost fluctuations under the presence of such an expanding classical color background field; the canonical quantization is done in the τ -η coordinates in order to take into account manifestly the expanding geometry. As a demonstration, we model the expanding classical color background field by a boost-invariantly expanding homogeneous color electric field with lifetime T , for which we obtain analytically the quark and gluon production spectra by solving the equations of motion of QCD nonperturbatively with respect to the color electric field. In this paper we study (i) the finite lifetime effect, which is found to modify significantly the particle spectra from those expected from the Schwinger formula; (ii) the difference between the quark and gluon production; and (iii) the quark mass dependence of the production spectra. Implications of these results to ultrarelativistic heavy ion collisions are also discussed.

Attitude control of the space construction base: A modular approach

NASA Technical Reports Server (NTRS)

Oconnor, D. A.

1982-01-01

A planar model of a space base and one module is considered. For this simplified system, a feedback controller which is compatible with the modular construction method is described. The systems dynamics are decomposed into two parts corresponding to base and module. The information structure of the problem is non-classical in that not all system information is supplied to each controller. The base controller is designed to accommodate structural changes that occur as the module is added and the module controller is designed to regulate its own states and follow commands from the base. Overall stability of the system is checked by Liapunov analysis and controller effectiveness is verified by computer simulation.

Carrier Modulation Via Waveform Probability Density Function

NASA Technical Reports Server (NTRS)

Williams, Glenn L.

2006-01-01

Beyond the classic modes of carrier modulation by varying amplitude (AM), phase (PM), or frequency (FM), we extend the modulation domain of an analog carrier signal to include a class of general modulations which are distinguished by their probability density function histogram. Separate waveform states are easily created by varying the pdf of the transmitted waveform. Individual waveform states are assignable as proxies for digital one's or zero's. At the receiver, these states are easily detected by accumulating sampled waveform statistics and performing periodic pattern matching, correlation, or statistical filtering. No fundamental physical laws are broken in the detection process. We show how a typical modulation scheme would work in the digital domain and suggest how to build an analog version. We propose that clever variations of the modulating waveform (and thus the histogram) can provide simple steganographic encoding.

Carrier Modulation Via Waveform Probability Density Function

NASA Technical Reports Server (NTRS)

Williams, Glenn L.

2004-01-01

Beyond the classic modes of carrier modulation by varying amplitude (AM), phase (PM), or frequency (FM), we extend the modulation domain of an analog carrier signal to include a class of general modulations which are distinguished by their probability density function histogram. Separate waveform states are easily created by varying the pdf of the transmitted waveform. Individual waveform states are assignable as proxies for digital ONEs or ZEROs. At the receiver, these states are easily detected by accumulating sampled waveform statistics and performing periodic pattern matching, correlation, or statistical filtering. No fundamental natural laws are broken in the detection process. We show how a typical modulation scheme would work in the digital domain and suggest how to build an analog version. We propose that clever variations of the modulating waveform (and thus the histogram) can provide simple steganographic encoding.

(Re)igniting a Sociological Imagination in Adult Education: The Continuing Relevance of Classical Theory

ERIC Educational Resources Information Center

Lange, Elizabeth

2015-01-01

This article argues that sociology has been a foundational discipline for the field of adult education, but it has been largely implicit, until recently. This article contextualizes classical theories of sociology within contemporary critiques, reviews the historical roots of sociology and then briefly introduces the classical theories…

Huygens' optical vector wave field synthesis via in-plane electric dipole metasurface.

PubMed

Park, Hyeonsoo; Yun, Hansik; Choi, Chulsoo; Hong, Jongwoo; Kim, Hwi; Lee, Byoungho

2018-04-16

We investigate Huygens' optical vector wave field synthesis scheme for electric dipole metasurfaces with the capability of modulating in-plane polarization and complex amplitude and discuss the practical issues involved in realizing multi-modulation metasurfaces. The proposed Huygens' vector wave field synthesis scheme identifies the vector Airy disk as a synthetic unit element and creates a designed vector optical field by integrating polarization-controlled and complex-modulated Airy disks. The metasurface structure for the proposed vector field synthesis is analyzed in terms of the signal-to-noise ratio of the synthesized field distribution. The design of practical metasurface structures with true vector modulation capability is possible through the analysis of the light field modulation characteristics of various complex modulated geometric phase metasurfaces. It is shown that the regularization of meta-atoms is a key factor that needs to be considered in field synthesis, given that it is essential for a wide range of optical field synthetic applications, including holographic displays, microscopy, and optical lithography.

Projecting light beams with 3D waveguide arrays

NASA Astrophysics Data System (ADS)

Crespi, Andrea; Bragheri, Francesca

2017-01-01

Free-space light beams with complex intensity patterns, or non-trivial phase structure, are demanded in diverse fields, ranging from classical and quantum optical communications, to manipulation and imaging of microparticles and cells. Static or dynamic spatial light modulators, acting on the phase or intensity of an incoming light wave, are the conventional choices to produce beams with such non-trivial characteristics. However, interfacing these devices with optical fibers or integrated optical circuits often requires difficult alignment or cumbersome optical setups. Here we explore theoretically and with numerical simulations the potentialities of directly using the output of engineered three-dimensional waveguide arrays, illuminated with linearly polarized light, to project light beams with peculiar structures. We investigate through a collection of illustrative configurations the far field distribution, showing the possibility to achieve orbital angular momentum, or to produce elaborate intensity or phase patterns with several singularity points. We also simulate the propagation of the projected beam, showing the possibility to concentrate light. We note that these devices should be at reach of current technology, thus perspectives are open for the generation of complex free-space optical beams from integrated waveguide circuits.

Topographic organization of the cerebral cortex and brain cartography.

PubMed

Eickhoff, Simon B; Constable, R Todd; Yeo, B T Thomas

2018-04-15

One of the most specific but also challenging properties of the brain is its topographic organization into distinct modules or cortical areas. In this paper, we first review the concept of topographic organization and its historical development. Next, we provide a critical discussion of the current definition of what constitutes a cortical area, why the concept has been so central to the field of neuroimaging and the challenges that arise from this view. A key aspect in this discussion is the issue of spatial scale and hierarchy in the brain. Focusing on in-vivo brain parcellation as a rapidly expanding field of research, we highlight potential limitations of the classical concept of cortical areas in the context of multi-modal parcellation and propose a revised interpretation of cortical areas building on the concept of neurobiological atoms that may be aggregated into larger units within and across modalities. We conclude by presenting an outlook on the implication of this revised concept for future mapping studies and raise some open questions in the context of brain parcellation. Copyright © 2017 Elsevier Inc. All rights reserved.

Dam break problem for the focusing nonlinear Schrödinger equation and the generation of rogue waves

NASA Astrophysics Data System (ADS)

El, G. A.; Khamis, E. G.; Tovbis, A.

2016-09-01

We propose a novel, analytically tractable, scenario of the rogue wave formation in the framework of the small-dispersion focusing nonlinear Schrödinger (NLS) equation with the initial condition in the form of a rectangular barrier (a ‘box’). We use the Whitham modulation theory combined with the nonlinear steepest descent for the semi-classical inverse scattering transform, to describe the evolution and interaction of two counter-propagating nonlinear wave trains—the dispersive dam break flows—generated in the NLS box problem. We show that the interaction dynamics results in the emergence of modulated large-amplitude quasi-periodic breather lattices whose amplitude profiles are closely approximated by the Akhmediev and Peregrine breathers within certain space-time domain. Our semi-classical analytical results are shown to be in excellent agreement with the results of direct numerical simulations of the small-dispersion focusing NLS equation.

A uniform geometrical optics and an extended uniform geometrical theory of diffraction for evaluating high frequency EM fields near smooth caustics and composite shadow boundaries

NASA Technical Reports Server (NTRS)

Constantinides, E. D.; Marhefka, R. J.

1994-01-01

A uniform geometrical optics (UGO) and an extended uniform geometrical theory of diffraction (EUTD) are developed for evaluating high frequency electromagnetic (EM) fields within transition regions associated with a two and three dimensional smooth caustic of reflected rays and a composite shadow boundary formed by the caustic termination or the confluence of the caustic with the reflection shadow boundary (RSB). The UGO is a uniform version of the classic geometrical optics (GO). It retains the simple ray optical expressions of classic GO and employs a new set of uniform reflection coefficients. The UGO also includes a uniform version of the complex GO ray field that exists on the dark side of the smooth caustic. The EUTD is an extension of the classic uniform geometrical theory of diffraction (UTD) and accounts for the non-ray optical behavior of the UGO reflected field near caustics by using a two-variable transition function in the expressions for the edge diffraction coefficients. It also uniformly recovers the classic UTD behavior of the edge diffracted field outside the composite shadow boundary transition region. The approach employed for constructing the UGO/EUTD solution is based on a spatial domain physical optics (PO) radiation integral representation for the fields which is then reduced using uniform asymptotic procedures. The UGO/EUTD analysis is also employed to investigate the far-zone RCS problem of plane wave scattering from two and three dimensional polynomial defined surfaces, and uniform reflection, zero-curvature, and edge diffraction coefficients are derived. Numerical results for the scattering and diffraction from cubic and fourth order polynomial strips are also shown and the UGO/EUTD solution is validated by comparison to an independent moment method (MM) solution. The UGO/EUTD solution is also compared with the classic GO/UTD solution. The failure of the classic techniques near caustics and composite shadow boundaries is clearly demonstrated and it is shown that the UGO/EUTD results remain valid and uniformly reduce to the classic results away from the transition regions. Mathematical details on the asymptotic properties and efficient numerical evaluation of the canonical functions involved in the UGO/EUTD expressions are also provided.

Nonlinear Schrödinger equation and classical-field description of thermal radiation

NASA Astrophysics Data System (ADS)

Rashkovskiy, Sergey A.

2018-03-01

It is shown that the thermal radiation can be described without quantization of energy in the framework of classical field theory using the nonlinear Schrödinger equation which is considered as a classical field equation. Planck's law for the spectral energy density of thermal radiation and the Einstein A-coefficient for spontaneous emission are derived without using the concept of the energy quanta. It is shown that the spectral energy density of thermal radiation is apparently not a universal function of frequency, as follows from the Planck's law, but depends weakly on the nature of atoms, while Planck's law is valid only as an approximation in the limit of weak excitation of atoms. Spin and relativistic effects are not considered in this paper.

The Initial Flow of Classical Gluon Fields in Heavy Ion Collisions

NASA Astrophysics Data System (ADS)

Fries, Rainer J.; Chen, Guangyao

2015-03-01

Using analytic solutions of the Yang-Mills equations we calculate the initial flow of energy of the classical gluon field created in collisions of large nuclei at high energies. We find radial and elliptic flow which follows gradients in the initial energy density, similar to a simple hydrodynamic behavior. In addition we find a rapidity-odd transverse flow field which implies the presence of angular momentum and should lead to directed flow in final particle spectra. We trace those energy flow terms to transverse fields from the non-abelian generalization of Gauss' Law and Ampere's and Faraday's Laws.

High-speed switching of biphoton delays through electro-optic pump frequency modulation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Odele, Ogaga D.; Lukens, Joseph M.; Jaramillo-Villegas, Jose A.

The realization of high-speed tunable delay control has received significant attention in the scene of classical photonics. In quantum optics, however, such rapid delay control systems for entangled photons have remained undeveloped. Here for the first time, we demonstrate rapid (2.5 MHz) modulation of signal-idler arrival times through electro-optic pump frequency modulation. Our technique applies the quantum phenomenon of nonlocal dispersion cancellation along with pump frequency tuning to control the relative delay between photon pairs. Chirped fiber Bragg gratings are employed to provide large amounts of dispersion which result in biphoton delays exceeding 30 ns. This rapid delay modulation schememore » could be useful for on-demand single-photon distribution in addition to quantum versions of pulse position modulation.« less

High-speed switching of biphoton delays through electro-optic pump frequency modulation

DOE PAGES

Odele, Ogaga D.; Lukens, Joseph M.; Jaramillo-Villegas, Jose A.; ...

2016-12-08

The realization of high-speed tunable delay control has received significant attention in the scene of classical photonics. In quantum optics, however, such rapid delay control systems for entangled photons have remained undeveloped. Here for the first time, we demonstrate rapid (2.5 MHz) modulation of signal-idler arrival times through electro-optic pump frequency modulation. Our technique applies the quantum phenomenon of nonlocal dispersion cancellation along with pump frequency tuning to control the relative delay between photon pairs. Chirped fiber Bragg gratings are employed to provide large amounts of dispersion which result in biphoton delays exceeding 30 ns. This rapid delay modulation schememore » could be useful for on-demand single-photon distribution in addition to quantum versions of pulse position modulation.« less

Distinctive receptive field and physiological properties of a wide-field amacrine cell in the macaque monkey retina

PubMed Central

Puller, Christian; Rieke, Fred; Neitz, Jay; Neitz, Maureen

2015-01-01

At early stages of visual processing, receptive fields are typically described as subtending local regions of space and thus performing computations on a narrow spatial scale. Nevertheless, stimulation well outside of the classical receptive field can exert clear and significant effects on visual processing. Given the distances over which they occur, the retinal mechanisms responsible for these long-range effects would certainly require signal propagation via active membrane properties. Here the physiology of a wide-field amacrine cell—the wiry cell—in macaque monkey retina is explored, revealing receptive fields that represent a striking departure from the classic structure. A single wiry cell integrates signals over wide regions of retina, 5–10 times larger than the classic receptive fields of most retinal ganglion cells. Wiry cells integrate signals over space much more effectively than predicted from passive signal propagation, and spatial integration is strongly attenuated during blockade of NMDA spikes but integration is insensitive to blockade of NaV channels with TTX. Thus these cells appear well suited for contributing to the long-range interactions of visual signals that characterize many aspects of visual perception. PMID:26133804

An elementary argument for the magnetic field outside a solenoid

NASA Astrophysics Data System (ADS)

Pathak, Aritro

2017-01-01

The evaluation of the magnetic field inside and outside a uniform current density infinite solenoid of uniform cross-section is an elementary problem in classical electrodynamics that all undergraduate Physics students study. Symmetry properties of the cylinder and the judicious use of Ampere’s circuital law leads to correct results; however it does not explain why the field is non zero for a finite length solenoid, and why it vanishes as the solenoid becomes infinitely long. An argument is provided in Farley and Price (2001 Am. J. Phys. 69 751), explaining how the magnetic field behaves outside the solenoid and not too far from it, as a function of the length of the solenoid. A calculation is also outlined for obtaining the field just outside the circular cross section solenoid, in the classic text Classical Electrodynamics by Jackson, 3rd edn (John Wiley and Sons, Inc.), problems 5.3-5.5. The purpose of this paper is to provide an elementary argument for why the field becomes negligible as the length of the solenoid is increased. A quantitative analysis is provided for the field outside the solenoid, at radial distances large compared to the linear dimension of the solenoid cross section.

Matching and selection of a specific subjective experience: conjugate matching and experience.

PubMed

Vimal, Ram Lakhan Pandey

2010-06-01

We incorporate the dual-mode concept in our dual-aspect PE-SE (proto-experience-subjective experience) framework. The two modes are: (1) the non-tilde mode that is the physical (material) and mental aspect of cognition (memory and attention) related feedback signals in a neural-network, which refers to the cognitive nearest past approaching towards present; and (2) the tilde mode that is the material and mental aspect of the feed-forward signals due to external environmental input and internal endogenous input, which pertains to the nearest future approaching towards present and is a entropy-reversed representation of non-tilde mode. Furthermore, one could argue that there are at least five sub-pathways in the stimulus-dependent feed-forward pathway and cognitive feedback pathway for information transfer in the brain dynamics: (i) classical axonal-dendritic neural sub-pathway including electromagnetic information field sub-pathway; (ii) quantum dendritic-dendritic microtubule (MT) (dendritic webs) sub-pathway; (iii) Ca(++)-related astroglial-neural sub-pathway; (iv) (a) the sub-pathway related to extrasynaptic signal transmission between fine distal dendrites of cortical neurons for the local subtle modulation due to voltages created by intradendritic dual-aspect charged surface effects within the Debye layer around endogenous structures such as microtubules (MT) and endoplasmic reticulum (ER) in dendrites, and (b) the sub-pathway related to extracellular volume transmission as fields of neural activity for the global modulation in axonal-dendritic neural sub-pathway; and (v) the sub-pathway related to information transmission via soliton propagation. We propose that: (i) the quantum conjugate matching between experiences in the mental aspect of the tilde mode and that of the non-tilde mode is related more to the mental aspect of the quantum microtubule-dendritic-web and less to that of the non-quantum sub-pathways; and (ii) the classical matching between experiences in the mental aspect of the tilde mode and that of the non-tilde mode is related to the mental aspect of the non-quantum sub-pathways (such as classical axonal-dendritic neural sub-pathway). In both cases, a specific SE is selected when the tilde mode interacts with the non-tilde mode to match for a specific SE, and when the necessary ingredients of SEs (such as the formation of neural networks, wakefulness, re-entry, attention, working memory, and so on) are satisfied. When the conjugate match is made between the two modes, the world-presence (Now) is disclosed. The material aspects in the tilde mode and that in the non-tilde mode are matched to link structure with function, whereas the mental aspects in the tilde mode and that in the non-tilde mode are matched to link experience with structure and function.

Spinomotive force induced by a transverse displacement current in a thin metal or doped-semiconductor sheet: Classical and quantum views.

NASA Astrophysics Data System (ADS)

Hu, Chia-Ren

2004-03-01

We present classical macroscopic, microscopic, and quantum mechanical arguments to show that in a metallic or electron/hole-doped semiconducting sheet thinner than the screening length, a displacement current applied normal to it can induce a spinomotive force along it. The magnitude is weak but clearly detectable. The classical arguments are purely electromagnetic. The quantum argument, based on the Dirac equation, shows that the predicted effect originates from the spin-orbit interaction, but not of the usual kind. That is, it relies on an external electric field, whereas the usual S-O interaction involves the electric field generated by the ions. Because the Dirac equation incorporatesThomas precession, which is due to relativistic kinematics, the quantum prediction is a factor of two smaller than the classical prediction. Replacing the displacement current by a charge current, and one obtains a new source for the spin-Hall effect. Classical macroscopic argument also predicts its existence, but the other two views are controversial.

Stochastic inflation in phase space: is slow roll a stochastic attractor?

NASA Astrophysics Data System (ADS)

Grain, Julien; Vennin, Vincent

2017-05-01

An appealing feature of inflationary cosmology is the presence of a phase-space attractor, ``slow roll'', which washes out the dependence on initial field velocities. We investigate the robustness of this property under backreaction from quantum fluctuations using the stochastic inflation formalism in the phase-space approach. A Hamiltonian formulation of stochastic inflation is presented, where it is shown that the coarse-graining procedure—where wavelengths smaller than the Hubble radius are integrated out—preserves the canonical structure of free fields. This means that different sets of canonical variables give rise to the same probability distribution which clarifies the literature with respect to this issue. The role played by the quantum-to-classical transition is also analysed and is shown to constrain the coarse-graining scale. In the case of free fields, we find that quantum diffusion is aligned in phase space with the slow-roll direction. This implies that the classical slow-roll attractor is immune to stochastic effects and thus generalises to a stochastic attractor regardless of initial conditions, with a relaxation time at least as short as in the classical system. For non-test fields or for test fields with non-linear self interactions however, quantum diffusion and the classical slow-roll flow are misaligned. We derive a condition on the coarse-graining scale so that observational corrections from this misalignment are negligible at leading order in slow roll.

Introduction to Classical Density Functional Theory by a Computational Experiment

ERIC Educational Resources Information Center

Jeanmairet, Guillaume; Levy, Nicolas; Levesque, Maximilien; Borgis, Daniel

2014-01-01

We propose an in silico experiment to introduce the classical density functional theory (cDFT). Density functional theories, whether quantum or classical, rely on abstract concepts that are nonintuitive; however, they are at the heart of powerful tools and active fields of research in both physics and chemistry. They led to the 1998 Nobel Prize in…

Quantum phase uncertainties in the classical limit

NASA Technical Reports Server (NTRS)

Franson, James D.

1994-01-01

Several sources of phase noise, including spontaneous emission noise and the loss of coherence due to which-path information, are examined in the classical limit of high field intensities. Although the origin of these effects may appear to be quantum-mechanical in nature, it is found that classical analogies for these effects exist in the form of chaos.

Time evolution of linearized gauge field fluctuations on a real-time lattice

NASA Astrophysics Data System (ADS)

Kurkela, A.; Lappi, T.; Peuron, J.

2016-12-01

Classical real-time lattice simulations play an important role in understanding non-equilibrium phenomena in gauge theories and are used in particular to model the prethermal evolution of heavy-ion collisions. Due to instabilities, small quantum fluctuations on top of the classical background may significantly affect the dynamics of the system. In this paper we argue for the need for a numerical calculation of a system of classical gauge fields and small linearized fluctuations in a way that keeps the separation between the two manifest. We derive and test an explicit algorithm to solve these equations on the lattice, maintaining gauge invariance and Gauss' law.

Reconstructing spacetime from the hologram, even in the classical limit, requires physics beyond the Planck scale

NASA Astrophysics Data System (ADS)

Berenstein, David; Miller, Alexandra

2016-09-01

In this paper, we argue that for classical configurations of gravity in the AdS/CFT setup, it is in general impossible to reconstruct the bulk geometry from the leading asymptotic behavior of the classical fields in gravity alone. This is possible sufficiently near the vacuum, but not more generally. We argue this by using a counter-example that utilizes the supersymmetric geometries constructed by Lin, Lunin, and Maldacena. In the dual quantum field theory, the additional data required to complete the geometry is encoded in modes that near the vacuum geometry lie beyond the Planck scale.

Temporal modulations in speech and music.

PubMed

Ding, Nai; Patel, Aniruddh D; Chen, Lin; Butler, Henry; Luo, Cheng; Poeppel, David

2017-10-01

Speech and music have structured rhythms. Here we discuss a major acoustic correlate of spoken and musical rhythms, the slow (0.25-32Hz) temporal modulations in sound intensity and compare the modulation properties of speech and music. We analyze these modulations using over 25h of speech and over 39h of recordings of Western music. We show that the speech modulation spectrum is highly consistent across 9 languages (including languages with typologically different rhythmic characteristics). A different, but similarly consistent modulation spectrum is observed for music, including classical music played by single instruments of different types, symphonic, jazz, and rock. The temporal modulations of speech and music show broad but well-separated peaks around 5 and 2Hz, respectively. These acoustically dominant time scales may be intrinsic features of speech and music, a possibility which should be investigated using more culturally diverse samples in each domain. Distinct modulation timescales for speech and music could facilitate their perceptual analysis and its neural processing. Copyright © 2017 Elsevier Ltd. All rights reserved.

Electric Field Distribution in High Voltage Power Modules Using Finite Element Simulations

NASA Astrophysics Data System (ADS)

Wang, Zhao; Liu, Yaoning

2018-03-01

With the development of the high voltage insulated gate bipolar transistor (IGBT) power module, it leads to serious problems concerning the electric field insulation. The electric field capabilities of the silicone gels used in the power module encapsulation directly affect the module insulation. Some solutions have been developed to optimize the electric field and reliability. In this letter, the finite element simulation was used to analyze and localize the maximum electric field position; solutions were proposed to improve the module insulation. It’s demonstrated that BaTiO3 silicone composite is a promising insulation material for high voltage power device.

The Geometry of the Arms Race. Applications of Elementary Game Theory to International Relations. Modules and Monographs in Undergraduate Mathematics and Its Applications Project. UMAP Unit 311.

ERIC Educational Resources Information Center

Brams, Steven J.; And Others

This unit views applications of elementary game theory to international relations. It is noted that of all the significant world problems, the nuclear arms race has proved one of the most intractable. The main concern of the module is to investigate a possible solution to the arms race, based on extending the classic two-person game of Prisoner's…

Critical properties of the classical XY and classical Heisenberg models: A renormalization group study

NASA Astrophysics Data System (ADS)

de Sousa, J. Ricardo; de Albuquerque, Douglas F.

1997-02-01

By using two approaches of renormalization group (RG), mean field RG (MFRG) and effective field RG (EFRG), we study the critical properties of the simple cubic lattice classical XY and classical Heisenberg models. The methods are illustrated by employing its simplest approximation version in which small clusters with one ( N‧ = 1) and two ( N = 2) spins are used. The thermal and magnetic critical exponents, Yt and Yh, and the critical parameter Kc are numerically obtained and are compared with more accurate methods (Monte Carlo, series expansion and ε-expansion). The results presented in this work are in excellent agreement with these sophisticated methods. We have also shown that the exponent Yh does not depend on the symmetry n of the Hamiltonian, hence the criteria of universality for this exponent is only a function of the dimension d.

Numerical analysis of field-modulated electroosmotic flows in microchannels with arbitrary numbers and configurations of discrete electrodes.

PubMed

Chao, Kan; Chen, Bo; Wu, Jiankang

2010-12-01

The formation of an electric double layer and electroosmosis are important theoretic foundations associated with microfluidic systems. Field-modulated electroosmotic flows in microchannels can be obtained by applying modulating electric fields in a direction perpendicular to a channel wall. This paper presents a systematic numerical analysis of modulated electroosmotic flows in a microchannel with discrete electrodes on the basis of the Poisson equation of electric fields in a liquid-solid coupled domain, the Navier-Stokes equation of liquid flow, and the Nernst-Planck equation of ion transport. These equations are nonlinearly coupled and are simultaneously solved numerically for the electroosmotic flow velocity, electric potential, and ion concentrations in the microchannel. A number of numerical examples of modulated electroosmotic flows in microchannels with discrete electrodes are presented, including single electrodes, symmetric/asymmetric double electrodes, and triple electrodes. Numerical results indicate that chaotic circulation flows, micro-vortices, and effective fluid mixing can be realized in microchannels by applying modulating electric fields with various electrode configurations. The interaction of a modulating field with an applied field along the channel is also discussed.

Field theory of hyperfluid

NASA Astrophysics Data System (ADS)

Ariki, Taketo

2018-02-01

A hyperfluid model is constructed on the basis of its action entirely free from external constraints, regarding the hyperfluid as a self-consistent classical field. Intrinsic hypermomentum is no longer a supplemental variable given by external constraints, but arises purely from the diffeomorphism covariance of dynamical field. The field-theoretic approach allows natural classification of a hyperfluid on the basis of its symmetry group and corresponding homogeneous space; scalar, spinor, vector, and tensor fluids are introduced as simple examples. Apart from phenomenological constraints, the theory predicts the hypermomentum exchange of fluid via field-theoretic interactions of various classes; fluid–fluid interactions, minimal and non-minimal SU(n) -gauge couplings, and coupling with metric-affine gravity are all successfully formulated within the classical regime.

Mean-field approximation for spacing distribution functions in classical systems

NASA Astrophysics Data System (ADS)

González, Diego Luis; Pimpinelli, Alberto; Einstein, T. L.

2012-01-01

We propose a mean-field method to calculate approximately the spacing distribution functions p(n)(s) in one-dimensional classical many-particle systems. We compare our method with two other commonly used methods, the independent interval approximation and the extended Wigner surmise. In our mean-field approach, p(n)(s) is calculated from a set of Langevin equations, which are decoupled by using a mean-field approximation. We find that in spite of its simplicity, the mean-field approximation provides good results in several systems. We offer many examples illustrating that the three previously mentioned methods give a reasonable description of the statistical behavior of the system. The physical interpretation of each method is also discussed.

Quantum Metrology beyond the Classical Limit under the Effect of Dephasing

NASA Astrophysics Data System (ADS)

Matsuzaki, Yuichiro; Benjamin, Simon; Nakayama, Shojun; Saito, Shiro; Munro, William J.

2018-04-01

Quantum sensors have the potential to outperform their classical counterparts. For classical sensing, the uncertainty of the estimation of the target fields scales inversely with the square root of the measurement time T . On the other hand, by using quantum resources, we can reduce this scaling of the uncertainty with time to 1 /T . However, as quantum states are susceptible to dephasing, it has not been clear whether we can achieve sensitivities with a scaling of 1 /T for a measurement time longer than the coherence time. Here, we propose a scheme that estimates the amplitude of globally applied fields with the uncertainty of 1 /T for an arbitrary time scale under the effect of dephasing. We use one-way quantum-computing-based teleportation between qubits to prevent any increase in the correlation between the quantum state and its local environment from building up and have shown that such a teleportation protocol can suppress the local dephasing while the information from the target fields keeps growing. Our method has the potential to realize a quantum sensor with a sensitivity far beyond that of any classical sensor.

Effect of modulator sorption on gradient shape in ion-exchange chromatography

NASA Technical Reports Server (NTRS)

Velayudhan, A.; Ladisch, M. R.; Mitchell, C. A. (Principal Investigator)

1995-01-01

Mobile phase additives, or modulators, are used in gradient elution chromatography to facilitate separation and reduce separation time. The modulators are usually assumed to be linearly adsorbed or unadsorbed. Here, the consequences of nonlinear modulator adsorption are examined for ion-exchange gradient elution through a series of simulations. Even when the buffer salt is identical to the modulator salt, gradient deformation is observed; the extent of deformation increases as the volume of the feed is increased. When the modulator salt is different from the buffer salt, unusual effects are observed, and the chromatograms are quite different from those predicted by classical gradient elution theory. In particular, local increases in the buffer concentration are found between feed bands, and serve to improve the separation. These effects become more pronounced as the feed volume increases, and could therefore prove valuable in preparative applications.

From classic to current: a look back on attention research in the American Journal of Psychology.

PubMed

Mounts, Jeffrey R W

2012-01-01

This review examines attention research appearing in The American Journal of Psychology over the journal's rich 125-year history. In particular, the review examines studies focused on selective attention's role in modulating the influence of distraction and the methods used to capture the nature of selective attention. Special attention is given to classic articles by Treisman (1964a, 1964b), Neisser (1963), and Eriksen and Rohrbaugh (1970), whose methods and results are examined in detail in light of current theory and research in selective attention.

Above-Threshold Ionization by an Elliptically Polarized Field: Quantum Tunneling Interferences and Classical Dodging

NASA Astrophysics Data System (ADS)

Paulus, G. G.; Zacher, F.; Walther, H.; Lohr, A.; Becker, W.; Kleber, M.

1998-01-01

Measurements of above-threshold ionization electron spectra in an elliptically polarized field as a function of the ellipticity are presented. In the rescattering regime, electron yields quickly drop with increasing ellipticity. The yields of lower-energy electrons rise again when circular polarization is approached. A classical explanation for these effects is provided. Additional local maxima in the yields of lower-energy electrons can be interpreted as being due to interferences of electron trajectories that tunnel out at different times within one cycle of the field.

Dynamic effects and applications for nanosecond pulsed electric fields in cells and tissues

NASA Astrophysics Data System (ADS)

Beebe, Stephen J.; Blackmore, Peter F.; Hall, Emily; White, Jody A.; Willis, Lauren K.; Fauntleroy, Laura; Kolb, Juergen F.; Schoenbach, Karl H.

2005-04-01

Nanosecond, high intensity pulsed electric fields [nsPEFs] that are below the plasma membrane [PM] charging time constant have decreasing effects on the PM and increasing effects on intracellular structures and functions as the pulse duration decreases. When human cell suspensions were exposed to nsPEFs where the electric fields were sufficiently intense [10-300ns, <=300 kV/cm.], apoptosis signaling pathways could be activated in several cell models. Multiple apoptosis markers were observed in Jurkat, HL-60, 3T3L1-preadipocytes, and isolated rat adipocytes including decreased cell size and number, caspase activation, DNA fragmentation, and/or cytochrome c release into the cytoplasm. Phosphatidylserine externalization was observed as a biological response to nsPEFs in 3T3-L1 preadipocytes and p53-wildtype and -null human colon carcinoma cells. B10.2 mouse fibrosarcoma tumors that were exposed to nsPEFs ex vivo and in vivo exhibited DNA fragmentation, elevated caspase activity, and reduced size and weight compared to contralateral sham-treated control tumors. When nsPEF conditions were below thresholds for apoptosis and classical PM electroporation, non-apoptotic responses were observed similar to those initiated through PM purinergic receptors in HL-60 cells and thrombin in human platelets. These included Ca2+ mobilization from intracellular stores [endoplasmic reticulum] and subsequently through store-operated Ca2+ channels in the PM. In addition, platelet activation measured as aggregation responses were observed in human platelets. Finally, when nsPEF conditions followed classical electroporation-mediated transfection, the expression intensity and number of GFP-expressing cells were enhanced above cells exposed to electroporation conditions alone. These studies demonstrate that application of nsPEFs to cells or tissues can modulate cell-signaling mechanisms with possible applications as a new basic science tool, cancer treatment, wound healing, and gene therapy.

Panning for SNuRMs: using cofactor profiling for the rational discovery of selective nuclear receptor modulators.

PubMed

Kremoser, Claus; Albers, Michael; Burris, Thomas P; Deuschle, Ulrich; Koegl, Manfred

2007-10-01

Drugs that target nuclear receptors are clinically, as well as commercially, successful. Their widespread use, however, is limited by an inherent propensity of nuclear receptors to trigger beneficial, as well as adverse, pharmacological effects upon drug activation. Hence, selective drugs that display reduced adverse effects, such as the selective estrogen receptor modulator (SERM) Raloxifene, have been developed by guidance through classical cell culture assays and animal trials. Full agonist and selective modulator nuclear receptor drugs, in general, differ by their ability to recruit certain cofactors to the receptor protein. Hence, systematic cofactor profiling is advancing into an approach for the rationally guided identification of selective NR modulators (SNuRMs) with improved therapeutic ratio.

Semi-classical approach to compute RABBITT traces in multi-dimensional complex field distributions.

PubMed

Lucchini, M; Ludwig, A; Kasmi, L; Gallmann, L; Keller, U

2015-04-06

We present a semi-classical model to calculate RABBITT (Reconstruction of Attosecond Beating By Interference of Two-photon Transitions) traces in the presence of a reference infrared field with a complex two-dimensional (2D) spatial distribution. The evolution of the electron spectra as a function of the pump-probe delay is evaluated starting from the solution of the classical equation of motion and incorporating the quantum phase acquired by the electron during the interaction with the infrared field. The total response to an attosecond pulse train is then evaluated by a coherent sum of the contributions generated by each individual attosecond pulse in the train. The flexibility of this model makes it possible to calculate spectrograms from non-trivial 2D field distributions. After confirming the validity of the model in a simple 1D case, we extend the discussion to describe the probe-induced phase in photo-emission experiments on an ideal metallic surface.

Radiation of a nonrelativistic particle during its finite motion in a central field

DOE Office of Scientific and Technical Information (OSTI.GOV)

Karnakov, B. M., E-mail: karnak@theor.mephi.ru; Korneev, Ph. A., E-mail: korneev@theor.mephi.ru; Popruzhenko, S. V.

The spectrum and expressions for the intensity of dipole radiation lines are obtained for a classical nonrelativistic charged particle that executes a finite aperiodic motion in an arbitrary central field along a non-closed trajectory. It is shown that, in this case of a conditionally periodic motion, the radiaton spectrum consists of two series of equally spaced lines. It is pointed out that, according to the correspondence principle, the rise of two such series in the classical theory corresponds to the well-known selection rule |{delta}l = 1 for the dipole radiation in a central field in quantum theory, where l ismore » the orbital angular momentum of the particle. The results obtained can be applied to the description of the radiation and the absorption of a classical collisionless electron plasma in nanoparticles irradiated by an intense laser field. As an example, the rate of collisionless absorption of electromagnetic wave energy in equilibrium isotropic nanoplasma is calculated.« less

Quantum and Classical OpticsEmerging Links

DTIC Science & Technology

2016-05-09

apparatus, the Young interferometer. Implementation of vector-space control directed at challenges in polarimetry have been mentioned and a number of...28 361–74 [5] Ambiguous issues in standard approaches to polarimetry can be clarified by recognizing classical optical entanglement. See Simon B N...Degree of polarization for optical near fields Phys. Rev. E 66 016615 Ellis J and Dogariu A 2005 Optical polarimetry of random fields Phys. Rev. Lett

Quantum theory of electromagnetic fields in a cosmological quantum spacetime

NASA Astrophysics Data System (ADS)

Lewandowski, Jerzy; Nouri-Zonoz, Mohammad; Parvizi, Ali; Tavakoli, Yaser

2017-11-01

The theory of quantum fields propagating on an isotropic cosmological quantum spacetime is reexamined by generalizing the scalar test field to an electromagnetic (EM) vector field. For any given polarization of the EM field on the classical background, the Hamiltonian can be written in the form of the Hamiltonian of a set of decoupled harmonic oscillators, each corresponding to a single mode of the field. In transition from the classical to quantum spacetime background, following the technical procedure given by Ashtekar et al. [Phys. Rev. D 79, 064030 (2009), 10.1103/PhysRevD.79.064030], a quantum theory of the test EM field on an effective (dressed) spacetime emerges. The nature of this emerging dressed geometry is independent of the chosen polarization, but it may depend on the energy of the corresponding field mode. Specifically, when the backreaction of the field on the quantum geometry is negligible (i.e., a test field approximation is assumed), all field modes probe the same effective background independent of the mode's energy. However, when the backreaction of the field modes on the quantum geometry is significant, by employing a Born-Oppenheimer approximation, it is shown that a rainbow (i.e., a mode-dependent) metric emerges. The emergence of this mode-dependent background in the Planck regime may have a significant effect on the creation of quantum particles. The production amount on the dressed background is computed and is compared with the familiar results on the classical geometry.

Transitioning NWChem to the Next Generation of Manycore Machines

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bylaska, Eric J.; Apra, Edoardo; Kowalski, Karol

The NorthWest Chemistry (NWChem) modeling software is a popular molecular chemistry simulation software that was designed from the start to work on massively parallel processing supercomputers[6, 28, 49]. It contains an umbrella of modules that today includes Self Consistent Field (SCF), second order Mller-Plesset perturbation theory (MP2), Coupled Cluster, multi-conguration selfconsistent eld (MCSCF), selected conguration interaction (CI), tensor contraction engine (TCE) many body methods, density functional theory (DFT), time-dependent density functional theory (TDDFT), real time time-dependent density functional theory, pseudopotential plane-wave density functional theory (PSPW), band structure (BAND), ab initio molecular dynamics, Car-Parrinello molecular dynamics, classical molecular dynamics (MD), QM/MM,more » AIMD/MM, GIAO NMR, COSMO, COSMO-SMD, and RISM solvation models, free energy simulations, reaction path optimization, parallel in time, among other capabilities[ 22]. Moreover new capabilities continue to be added with each new release.« less

Baseball caps of the Atlanta Braves and Cleveland Indians in the flight deck

NASA Image and Video Library

1995-10-25

STS073-E-5135 (26 Oct. 1995) --- Baseball caps from the two 1995 World Series representative franchises float near the cabin windows of the Earth-orbiting space shuttle Columbia, with the Earth in the background. The American League champion Cleveland Indians and their National League counterpart Atlanta Braves were engaged in a scheduled best-of-seven World Series throughout the first portion of the scheduled 16-day mission in space. Off-duty crewmembers came out of a rest period to set up the scene in tribute to the October classic. The crew will continue working in shifts around the clock on a diverse assortment of United States Microgravity Laboratory (USML-2) experiments located in the science module. Fields of study include fluid physics, materials science, biotechnology, combustion science and commercial space processing technologies. The frame was exposed with an Electronic Still Camera (ESC).

Harmonic component detection: Optimized Spectral Kurtosis for operational modal analysis

NASA Astrophysics Data System (ADS)

Dion, J.-L.; Tawfiq, I.; Chevallier, G.

2012-01-01

This work is a contribution in the field of Operational Modal Analysis to identify the modal parameters of mechanical structures using only measured responses. The study deals with structural responses coupled with harmonic components amplitude and frequency modulated in a short range, a common combination for mechanical systems with engines and other rotating machines in operation. These harmonic components generate misleading data interpreted erroneously by the classical methods used in OMA. The present work attempts to differentiate maxima in spectra stemming from harmonic components and structural modes. The detection method proposed is based on the so-called Optimized Spectral Kurtosis and compared with others definitions of Spectral Kurtosis described in the literature. After a parametric study of the method, a critical study is performed on numerical simulations and then on an experimental structure in operation in order to assess the method's performance.

A new FPGA architecture suitable for DSP applications

NASA Astrophysics Data System (ADS)

Liyun, Wang; Jinmei, Lai; Jiarong, Tong; Pushan, Tang; Xing, Chen; Xueyan, Duan; Liguang, Chen; Jian, Wang; Yuan, Wang

2011-05-01

A new FPGA architecture suitable for digital signal processing applications is presented. DSP modules can be inserted into FPGA conveniently with the proposed architecture, which is much faster when used in the field of digital signal processing compared with traditional FPGAs. An advanced 2-level MUX (multiplexer) is also proposed. With the added SLEEP MODE PASS to traditional 2-level MUX, static leakage is reduced. Furthermore, buffers are inserted at early returns of long lines. With this kind of buffer, the delay of the long line is improved by 9.8% while the area increases by 4.37%. The layout of this architecture has been taped out in standard 0.13 μm CMOS technology successfully. The die size is 6.3 × 4.5 mm2 with the QFP208 package. Test results show that performances of presented classical DSP cases are improved by 28.6%-302% compared with traditional FPGAs.

Immunomodulation of classical and non-classical HLA molecules by ionizing radiation.

PubMed

Gallegos, Cristina E; Michelin, Severino; Dubner, Diana; Carosella, Edgardo D

2016-05-01

Radiotherapy has been employed for the treatment of oncological patients for nearly a century, and together with surgery and chemotherapy, radiation oncology constitutes one of the three pillars of cancer therapy. Ionizing radiation has complex effects on neoplastic cells and on tumor microenvironment: beyond its action as a direct cytotoxic agent, tumor irradiation triggers a series of alterations in tumoral cells, which includes the de novo synthesis of particular proteins and the up/down-regulation of cell surface molecules. Additionally, ionizing radiation may induce the release of "danger signals" which may, in turn lead to cellular and molecular responses by the immune system. This immunomodulatory action of ionizing radiation highlights the importance of the combined use (radiotherapy plus immunotherapy) for cancer healing. Major histocompatibility complex antigens (also called Human Leukocyte Antigens, HLA in humans) are one of those molecules whose expression is modulated after irradiation. This review summarizes the modulatory properties of ionizing radiation on the expression of HLA class I (classical and non-classical) and class II molecules, with special emphasis in non-classical HLA-I molecules. Copyright © 2016 Elsevier Inc. All rights reserved.

Contextual modulation revealed by optical imaging exhibits figural asymmetry in macaque V1 and V2.

PubMed

Zarella, Mark D; Ts'o, Daniel Y

2017-01-01

Neurons in early visual cortical areas are influenced by stimuli presented well beyond the confines of their classical receptive fields, endowing them with the ability to encode fine-scale features while also having access to the global context of the visual scene. This property can potentially define a role for the early visual cortex to contribute to a number of important visual functions, such as surface segmentation and figure-ground segregation. It is unknown how extraclassical response properties conform to the functional architecture of the visual cortex, given the high degree of functional specialization in areas V1 and V2. We examined the spatial relationships of contextual activations in macaque V1 and V2 with intrinsic signal optical imaging. Using figure-ground stimulus configurations defined by orientation or motion, we found that extraclassical modulation is restricted to the cortical representations of the figural component of the stimulus. These modulations were positive in sign, suggesting a relative enhancement in neuronal activity that may reflect an excitatory influence. Orientation and motion cues produced similar patterns of activation that traversed the functional subdivisions of V2. The asymmetrical nature of the enhancement demonstrated the capacity for visual cortical areas as early as V1 to contribute to figure-ground segregation, and the results suggest that this information can be extracted from the population activity constrained only by retinotopy, and not the underlying functional organization.

Contextual modulation revealed by optical imaging exhibits figural asymmetry in macaque V1 and V2

PubMed Central

Zarella, Mark D; Ts’o, Daniel Y

2017-01-01

Neurons in early visual cortical areas are influenced by stimuli presented well beyond the confines of their classical receptive fields, endowing them with the ability to encode fine-scale features while also having access to the global context of the visual scene. This property can potentially define a role for the early visual cortex to contribute to a number of important visual functions, such as surface segmentation and figure–ground segregation. It is unknown how extraclassical response properties conform to the functional architecture of the visual cortex, given the high degree of functional specialization in areas V1 and V2. We examined the spatial relationships of contextual activations in macaque V1 and V2 with intrinsic signal optical imaging. Using figure–ground stimulus configurations defined by orientation or motion, we found that extraclassical modulation is restricted to the cortical representations of the figural component of the stimulus. These modulations were positive in sign, suggesting a relative enhancement in neuronal activity that may reflect an excitatory influence. Orientation and motion cues produced similar patterns of activation that traversed the functional subdivisions of V2. The asymmetrical nature of the enhancement demonstrated the capacity for visual cortical areas as early as V1 to contribute to figure–ground segregation, and the results suggest that this information can be extracted from the population activity constrained only by retinotopy, and not the underlying functional organization. PMID:28761385

Location-dependent excitatory synaptic interactions in pyramidal neuron dendrites.

PubMed

Behabadi, Bardia F; Polsky, Alon; Jadi, Monika; Schiller, Jackie; Mel, Bartlett W

2012-01-01

Neocortical pyramidal neurons (PNs) receive thousands of excitatory synaptic contacts on their basal dendrites. Some act as classical driver inputs while others are thought to modulate PN responses based on sensory or behavioral context, but the biophysical mechanisms that mediate classical-contextual interactions in these dendrites remain poorly understood. We hypothesized that if two excitatory pathways bias their synaptic projections towards proximal vs. distal ends of the basal branches, the very different local spike thresholds and attenuation factors for inputs near and far from the soma might provide the basis for a classical-contextual functional asymmetry. Supporting this possibility, we found both in compartmental models and electrophysiological recordings in brain slices that the responses of basal dendrites to spatially separated inputs are indeed strongly asymmetric. Distal excitation lowers the local spike threshold for more proximal inputs, while having little effect on peak responses at the soma. In contrast, proximal excitation lowers the threshold, but also substantially increases the gain of distally-driven responses. Our findings support the view that PN basal dendrites possess significant analog computing capabilities, and suggest that the diverse forms of nonlinear response modulation seen in the neocortex, including uni-modal, cross-modal, and attentional effects, could depend in part on pathway-specific biases in the spatial distribution of excitatory synaptic contacts onto PN basal dendritic arbors.

Does Bohm's Quantum Force Have a Classical Origin?

NASA Astrophysics Data System (ADS)

Lush, David C.

2016-08-01

In the de Broglie-Bohm formulation of quantum mechanics, the electron is stationary in the ground state of hydrogenic atoms, because the quantum force exactly cancels the Coulomb attraction of the electron to the nucleus. In this paper it is shown that classical electrodynamics similarly predicts the Coulomb force can be effectively canceled by part of the magnetic force that occurs between two similar particles each consisting of a point charge moving with circulatory motion at the speed of light. Supposition of such motion is the basis of the Zitterbewegung interpretation of quantum mechanics. The magnetic force between two luminally-circulating charges for separation large compared to their circulatory motions contains a radial inverse square law part with magnitude equal to the Coulomb force, sinusoidally modulated by the phase difference between the circulatory motions. When the particles have equal mass and their circulatory motions are aligned but out of phase, part of the magnetic force is equal but opposite the Coulomb force. This raises a possibility that the quantum force of Bohmian mechanics may be attributable to the magnetic force of classical electrodynamics. It is further shown that relative motion between the particles leads to modulation of the magnetic force with spatial period equal to the de Broglie wavelength.

Fault-tolerant NAND-flash memory module for next-generation scientific instruments

NASA Astrophysics Data System (ADS)

Lange, Tobias; Michel, Holger; Fiethe, Björn; Michalik, Harald; Walter, Dietmar

2015-10-01

Remote sensing instruments on today's space missions deliver a high amount of data which is typically evaluated on ground. Especially for deep space missions the telemetry downlink is very limited which creates the need for the scientific evaluation and thereby a reduction of data volume already on-board the spacecraft. A demanding example is the Polarimetric and Helioseismic Imager (PHI) instrument on Solar Orbiter. To enable on-board offline processing for data reduction, the instrument has to be equipped with a high capacity memory module. The module is based on non-volatile NAND-Flash technology, which requires more advanced operation than volatile DRAM. Unlike classical mass memories, the module is integrated into the instrument and allows readback of data for processing. The architecture and safe operation of such kind of memory module is described in the following paper.

Vacuum polarization and Hawking radiation

NASA Astrophysics Data System (ADS)

Rahmati, Shohreh

Quantum gravity is one of the interesting fields in contemporary physics which is still in progress. The purpose of quantum gravity is to present a quantum description for spacetime at 10-33cm or find the 'quanta' of gravitational interaction.. At present, the most viable theory to describe gravitational interaction is general relativity which is a classical theory. Semi-classical quantum gravity or quantum field theory in curved spacetime is an approximation to a full quantum theory of gravity. This approximation considers gravity as a classical field and matter fields are quantized. One interesting phenomena in semi-classical quantum gravity is Hawking radiation. Hawking radiation was derived by Stephen Hawking as a thermal emission of particles from the black hole horizon. In this thesis we obtain the spectrum of Hawking radiation using a new method. Vacuum is defined as the possible lowest energy state which is filled with pairs of virtual particle-antiparticle. Vacuum polarization is a consequence of pair creation in the presence of an external field such as an electromagnetic or gravitational field. Vacuum polarization in the vicinity of a black hole horizon can be interpreted as the cause of the emission from black holes known as Hawking radiation. In this thesis we try to obtain the Hawking spectrum using this approach. We re-examine vacuum polarization of a scalar field in a quasi-local volume that includes the horizon. We study the interaction of a scalar field with the background gravitational field of the black hole in the desired quasi-local region. The quasi-local volume is a hollow cylinder enclosed by two membranes, one inside the horizon and one outside the horizon. The net rate of particle emission can be obtained as the difference of the vacuum polarization from the outer boundary and inner boundary of the cylinder. Thus we found a new method to derive Hawking emission which is unitary and well defined in quantum field theory.

Observation of matter wave beat phenomena in the macrodomain for electrons moving along a magnetic field

NASA Astrophysics Data System (ADS)

Varma, Ram K.; Punithavelu, A. M.; Banerjee, S. B.

2002-02-01

We report here the observations that exhibit the existence of matter wave phenomena with wavelength in the macrodomain of a few centimeters, for electrons moving along a magnetic field from an electron gun to a collector plate situated behind a grounded grid. These are in accordance with the predictions of a quantumlike theory for charged particles in the classical macrodomain, given by one of the authors [R. K. Varma, Phys. Rev. A 31, 3951 (1985)] with a recent generalization [R. K. Varma, Phys. Rev. E 64, 036608 (2001)]. The beats correspond to two closely spaced ``frequencies'' in the system, with the beat frequency given, in accordance with the characteristics of a wave phenomena, by the difference between the two frequencies. The beats ride as a modulation over a discrete energy band structure obtained with only one frequency present. The frequency here corresponds to the distance between the electron gun and the detector plate as it characterizes the variation in the energy band structure as the electron energy is swept. The second ``frequency'' corresponds to the gun-grid distance. These observations of the beats of matter waves in this experiment, with characteristics in accordance with the wave algorithm, then establish unambiguously the existence of macroscopic matter waves for electrons propagating along a magnetic field.

The neurophysiology of figure-ground segregation in primary visual cortex.

PubMed

Lamme, V A

1995-02-01

The activity of neurons in the primary visual cortex of the awake macaque monkey was recorded while the animals were viewing full screen arrays of either oriented line segments or moving random dots. A square patch of the screen was made to perceptually pop out as a circumscribed figure by virtue of differences between the orientation or the direction of motion of the texture elements within that patch and the surround. The animals were trained to identify the figure patches by making saccadic eye movements towards their positions. Almost every cell gave a significantly larger response to elements belonging to the figure than to similar elements belonging to the background. The figure-ground response enhancement was present along the entire extent of the patch and was absent as soon as the receptive field was outside the patch. The strength of the effect had no relation with classical receptive field properties like orientation or direction selectivity or receptive field size. The response enhancement had a latency of 30-40 msec relative to the onset of the neuronal response itself. The results show that context modulation within primary visual cortex has a highly sophisticated nature, putting the image features the cells are responding to into their fully evaluated perceptual context.

The Integrated Taxonomy of Health Care: Classifying Both Complementary and Biomedical Practices Using a Uniform Classification Protocol

PubMed Central

Porcino, Antony; MacDougall, Colleen

2009-01-01

Background: Since the late 1980s, several taxonomies have been developed to help map and describe the interrelationships of complementary and alternative medicine (CAM) modalities. In these taxonomies, several issues are often incompletely addressed: A simple categorization process that clearly isolates a modality to a single conceptual categoryClear delineation of verticality—that is, a differentiation of scale being observed from individually applied techniques, through modalities (therapies), to whole medical systemsRecognition of CAM as part of the general field of health care Methods: Development of the Integrated Taxonomy of Health Care (ITHC) involved three stages: Development of a precise, uniform health glossaryAnalysis of the extant taxonomiesUse of an iterative process of classifying modalities and medical systems into categories until a failure to singularly classify a modality occurred, requiring a return to the glossary and adjustment of the classifying protocol Results: A full vertical taxonomy was developed that includes and clearly differentiates between techniques, modalities, domains (clusters of similar modalities), systems of health care (coordinated care system involving multiple modalities), and integrative health care. Domains are the classical primary focus of taxonomies. The ITHC has eleven domains: chemical/substance-based work, device-based work, soft tissue–focused manipulation, skeletal manipulation, fitness/movement instruction, mind–body integration/classical somatics work, mental/emotional–based work, bio-energy work based on physical manipulation, bio-energy modulation, spiritual-based work, unique assessments. Modalities are assigned to the domains based on the primary mode of interaction with the client, according the literature of the practitioners. Conclusions: The ITHC has several strengths: little interpretation is used while successfully assigning modalities to single domains; the issue of taxonomic verticality is fully resolved; and the design fully integrates the complementary health care fields of biomedicine and CAM. PMID:21589735

An LED solar simulator for student labs

NASA Astrophysics Data System (ADS)

González, Manuel I.

2017-05-01

Measuring voltage-current and voltage-power curves of a photovoltaic module is a nice experiment for high school and undergraduate students. In labs where real sunlight is not available this experiment requires a solar simulator. A prototype of a simulator using LED lamps has been manufactured and tested, and a comparison with classical halogen simulators has been performed. It is found that LED light offers lower levels of irradiance, but much better performance in terms of module output for a given irradiance.

Derivation of the cut-off length from the quantum quadratic enhancement of a mass in vacuum energy constant Lambda

NASA Astrophysics Data System (ADS)

Fukushima, Kimichika; Sato, Hikaru

2018-04-01

Ultraviolet self-interaction energies in field theory sometimes contain meaningful physical quantities. The self-energies in such as classical electrodynamics are usually subtracted from the rest mass. For the consistent treatment of energies as sources of curvature in the Einstein field equations, this study includes these subtracted self-energies into vacuum energy expressed by the constant Lambda (used in such as Lambda-CDM). In this study, the self-energies in electrodynamics and macroscopic classical Einstein field equations are examined, using the formalisms with the ultraviolet cut-off scheme. One of the cut-off formalisms is the field theory in terms of the step-function-type basis functions, developed by the present authors. The other is a continuum theory of a fundamental particle with the same cut-off length. Based on the effectiveness of the continuum theory with the cut-off length shown in the examination, the dominant self-energy is the quadratic term of the Higgs field at a quantum level (classical self-energies are reduced to logarithmic forms by quantum corrections). The cut-off length is then determined to reproduce today's tiny value of Lambda for vacuum energy. Additionally, a field with nonperiodic vanishing boundary conditions is treated, showing that the field has no zero-point energy.

Liquid Crystal Spatial Light Modulators for Simulating Zonal Multifocal Lenses.

PubMed

Li, Yiyu; Bradley, Arthur; Xu, Renfeng; Kollbaum, Pete S

2017-09-01

To maximize efficiency of the normally lengthy and costly multizone lens design and testing process, it is advantageous to evaluate the potential efficacy of a design as thoroughly as possible prior to lens fabrication and on-eye testing. The current work describes an ex vivo approach of optical design testing. The aim of this study was to describe a system capable of examining the optical characteristics of multizone bifocal and multifocal optics by subaperture stitching using liquid crystal technologies. A liquid crystal spatial light modulator (SLM) was incorporated in each of two channels to generate complementary subapertures by amplitude modulation. Additional trial lenses and phase plates were placed in pupil conjugate planes of either channel to integrate the desired bifocal and multifocal optics once the two optical paths were recombined. A high-resolution Shack-Hartmann aberrometer was integrated to measure the optics of the dual-channel system. Power and wavefront error maps as well as point spread functions were measured and computed for each of three multizone multifocal designs. High transmission modulation was achieved by introducing half-wavelength optical path differences to create two- and five-zone bifocal apertures. Dual-channel stitching revealed classic annular rings in the point spread functions generated from two-zone designs when the outer annular optic was defocused. However, low efficiency of the SLM prevented us from simultaneously measuring the eye + simulator aberrations, and the higher-order diffraction patterns generated by the cellular structure of the liquid crystal arrays limited the visual field to ±0.45 degrees. The system successfully simulated bifocal and multifocal simultaneous lenses allowing for future evaluation of both objective and subjective evaluation of complex optical designs. However, low efficiency and diffraction phenomena of the SLM limit the utility of this technology for simulating multizone and multifocal optics.

The effects of control field detuning on the modulation instability in a three-level quantum well system

DOE Office of Scientific and Technical Information (OSTI.GOV)

Borgohain, Nitu, E-mail: nituborgohain.ism@gmail.com; Konar, S.

The paper presents a theoretical study of the modulation instability of a continuous or quasi-continuous optical probe in a three level quantum well system under electromagnetically induced transparency. The modulation instability is affected by the control field detuning, as well as even-order dispersion and by the strength of Kerr (third-order) and quintic (fifth-order) nonlinearities. The fourth-order dispersion reduces the bandwidth over which modulation instability occurs, whereas the quintic nonlinearity saturates the growth of the modulation instability. Detuning the control field from resonance can significantly reduce the growth of the modulation instability at both low and high power levels. At lowmore » powers, the system becomes stable against modulation instability for small detuning of the control field and at high powers modulation instability disappears for larger detuning.« less

Innate immune humoral factors, C1q and factor H, with differential pattern recognition properties, alter macrophage response to carbon nanotubes.

PubMed

Pondman, Kirsten M; Pednekar, Lina; Paudyal, Basudev; Tsolaki, Anthony G; Kouser, Lubna; Khan, Haseeb A; Shamji, Mohamed H; Ten Haken, Bennie; Stenbeck, Gudrun; Sim, Robert B; Kishore, Uday

2015-11-01

Interaction between the complement system and carbon nanotubes (CNTs) can modify their intended biomedical applications. Pristine and derivatised CNTs can activate complement primarily via the classical pathway which enhances uptake of CNTs and suppresses pro-inflammatory response by immune cells. Here, we report that the interaction of C1q, the classical pathway recognition molecule, with CNTs involves charge pattern and classical pathway activation that is partly inhibited by factor H, a complement regulator. C1q and its globular modules, but not factor H, enhanced uptake of CNTs by macrophages and modulated the pro-inflammatory immune response. Thus, soluble complement factors can interact differentially with CNTs and alter the immune response even without complement activation. Coating CNTs with recombinant C1q globular heads offers a novel way of controlling classical pathway activation in nanotherapeutics. Surprisingly, the globular heads also enhance clearance by phagocytes and down-regulate inflammation, suggesting unexpected complexity in receptor interaction. Carbon nanotubes (CNTs) maybe useful in the clinical setting as targeting drug carriers. However, it is also well known that they can interact and activate the complement system, which may have a negative impact on the applicability of CNTs. In this study, the authors functionalized multi-walled CNT (MWNT), and investigated the interaction with the complement pathway. These studies are important so as to gain further understanding of the underlying mechanism in preparation for future use of CNTs in the clinical setting. Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.

Laryngeal dynamics of pedagogical taan gestures in Indian classical singing.

PubMed

Radhakrishnan, Nandhakumar; Scherer, Ronald C; Bandyopadhyay, Santanu

2011-05-01

Vocal modulations characterize many styles of singing. Vibrato, trill, and trillo are some of the ornaments that Western classical singers use. Likewise, taan is one of the basic frequency modulations demonstrated by Hindustani Indian classical singers. The objective of this descriptive study was to discover the F₀ contour of taan; establish selected acoustic, aerodynamic, and glottographic characteristics of the taan gesture; and explore the pedagogical taan utterances demonstrated by a well-known singer and teacher. Exploratory. Fundamental frequency, alternating current (AC) glottal flow, and electroglottographic width measures were obtained for taan productions by the classical Indian singer and teacher who demonstrated taan rate variations based on his pedagogical approach. The structure of the taan gesture was found to be an F₀ lowering and rising (the "taan dip") followed by a relatively flat portion (the "taan superior surface"). Rate of the F₀ structure of the taan gestures ranged from approximately 1.65 to 3.41Hz, and the F₀ extent ranged from 1.87 to 2.21semitone (ST). As the rate of the taan gesture increased, the superior surface shortened, whereas the taan dip stayed relatively constant (ranging from 170 to 230 ms). AC flow was greater for the lowest frequencies of the dip and faster rates. The pedagogical taan gesture has a specific structure of an F₀ dip followed by a relatively flat F₀ portion that shortens as taan rate increases. The F₀ dip and extent are relatively robust across rate. The taan productions are voluntarily controlled, in contrast to vibrato productions. Copyright © 2011 The Voice Foundation. Published by Mosby, Inc. All rights reserved.

Shapes, spectra and new methods in nonlinear spatial optics

NASA Astrophysics Data System (ADS)

Sun, Can

For a myriad of optical applications, the quality of the light source is poor and the beam is inherently spatially partially-coherent. For this broad class of systems, wave dynamics depends not only on the wave intensity, but also on its distribution of spatial frequencies. Unfortunately, this entire spectrum of problems has often been overlooked - for reasons of theoretical ease or experimental difficulties. Here, we remedy this by demonstrating a novel experimental setup which, for the first time, allows arbitrarily modulation of the spatial spectra of light to obtain any distribution of interest. Using modulation instability as an example, we isolate the effect of different spectral shapes and observe distinct beam dynamics. Next, we turn to a thermodynamic description of the long-term evolution of statistical fields. For quantum systems, a major consequence is Bose-Einstein Condensation. However, recent theoretical studies have suggested that quantum mechanics is not necessary for the condensation process: classical waves with random phases can also self-organize into a coherent state. Starting from a random ensemble, nonlinear interactions can lead to a turbulent energy cascade towards longer spatial scales. In complete analogy with the kinetics of a gas system, there is a statistical dynamics of waves in which particle velocities map to wavepacket k-vectors while collisions are mimicked by four-wave mixing. As with collisions, each wave interaction is formally reversible, yet entropy principles mandate that the ensemble evolves towards an equilibrium state of maximum disorder. The result is an equipartition of energy, in the form of a Rayleigh-Jeans spectrum, with information about the condensation process recorded in small-scale fluctuations. Here, we give the first experimental observation of the condensation of classical waves in any media. Using classical light in a self-defocusing photorefractive, we observe all aspects of the condensation process, including the population of a coherent state, spectral redistribution towards the Rayleigh-Jeans spectrum, and formal reversibility of the interactions. The latter is proved experimentally by introducing a digital "Maxwell's Demon" to reverse (phase-conjugate) the momentum of each wavepacket and recover the original "thermal cloud". The results integrate digital and physical methods of nonlinear processing, confirm fundamental ideas in wave turbulence, and greatly extend the range of Bose-Einstein theory.

Apparel Research Network (ARN); Apparel Order Processing Module (AOPM): Field User Manual, Version 1

DTIC Science & Technology

1997-09-30

changes. Cancel Button Closes the Site Information Screen, abandoning changes. APPAREL ORDER PROCESSING MODULE FIELD USER MANUAL Ordering Official...on the Ordering Official Information Screen. APPAREL ORDER PROCESSING MODULE FIELD USER MANUAL Ordering Official Information Screen (Jjj

Principles of Discrete Time Mechanics

NASA Astrophysics Data System (ADS)

Jaroszkiewicz, George

2014-04-01

1. Introduction; 2. The physics of discreteness; 3. The road to calculus; 4. Temporal discretization; 5. Discrete time dynamics architecture; 6. Some models; 7. Classical cellular automata; 8. The action sum; 9. Worked examples; 10. Lee's approach to discrete time mechanics; 11. Elliptic billiards; 12. The construction of system functions; 13. The classical discrete time oscillator; 14. Type 2 temporal discretization; 15. Intermission; 16. Discrete time quantum mechanics; 17. The quantized discrete time oscillator; 18. Path integrals; 19. Quantum encoding; 20. Discrete time classical field equations; 21. The discrete time Schrodinger equation; 22. The discrete time Klein-Gordon equation; 23. The discrete time Dirac equation; 24. Discrete time Maxwell's equations; 25. The discrete time Skyrme model; 26. Discrete time quantum field theory; 27. Interacting discrete time scalar fields; 28. Space, time and gravitation; 29. Causality and observation; 30. Concluding remarks; Appendix A. Coherent states; Appendix B. The time-dependent oscillator; Appendix C. Quaternions; Appendix D. Quantum registers; References; Index.

Classical geometry to quantum behavior correspondence in a virtual extra dimension

NASA Astrophysics Data System (ADS)

Dolce, Donatello

2012-09-01

In the Lorentz invariant formalism of compact space-time dimensions the assumption of periodic boundary conditions represents a consistent semi-classical quantization condition for relativistic fields. In Dolce (2011) [18] we have shown, for instance, that the ordinary Feynman path integral is obtained from the interference between the classical paths with different winding numbers associated with the cyclic dynamics of the field solutions. By means of the boundary conditions, the kinematical information of interactions can be encoded on the relativistic geometrodynamics of the boundary, see Dolce (2012) [8]. Furthermore, such a purely four-dimensional theory is manifestly dual to an extra-dimensional field theory. The resulting correspondence between extra-dimensional geometrodynamics and ordinary quantum behavior can be interpreted in terms of AdS/CFT correspondence. By applying this approach to a simple Quark-Gluon-Plasma freeze-out model we obtain fundamental analogies with basic aspects of AdS/QCD phenomenology.

A note on powers in finite fields

NASA Astrophysics Data System (ADS)

Aabrandt, Andreas; Lundsgaard Hansen, Vagn

2016-08-01

The study of solutions to polynomial equations over finite fields has a long history in mathematics and is an interesting area of contemporary research. In recent years, the subject has found important applications in the modelling of problems from applied mathematical fields such as signal analysis, system theory, coding theory and cryptology. In this connection, it is of interest to know criteria for the existence of squares and other powers in arbitrary finite fields. Making good use of polynomial division in polynomial rings over finite fields, we have examined a classical criterion of Euler for squares in odd prime fields, giving it a formulation that is apt for generalization to arbitrary finite fields and powers. Our proof uses algebra rather than classical number theory, which makes it convenient when presenting basic methods of applied algebra in the classroom.

Mean-field approximation for spacing distribution functions in classical systems.

PubMed

González, Diego Luis; Pimpinelli, Alberto; Einstein, T L

2012-01-01

We propose a mean-field method to calculate approximately the spacing distribution functions p((n))(s) in one-dimensional classical many-particle systems. We compare our method with two other commonly used methods, the independent interval approximation and the extended Wigner surmise. In our mean-field approach, p((n))(s) is calculated from a set of Langevin equations, which are decoupled by using a mean-field approximation. We find that in spite of its simplicity, the mean-field approximation provides good results in several systems. We offer many examples illustrating that the three previously mentioned methods give a reasonable description of the statistical behavior of the system. The physical interpretation of each method is also discussed. © 2012 American Physical Society

Classical Hall Effect without Magnetic Field

NASA Astrophysics Data System (ADS)

Schade, Nicholas; Tao, Chiao-Yu; Schuster, David; Nagel, Sidney

We show that the sign and density of charge carriers in a material can be obtained without the presence of a magnetic field. This effect, analogous to the classical Hall effect, is due solely to the geometry of the current-carrying wire. When current flows, surface charges along the wire create small electric fields that direct the current to follow the path of the conductor. In a curved wire, the charge carriers must experience a centripetal force, which arises from an electric field perpendicular to the drift velocity. This electric field produces a potential difference between the sides of the wire that depends on the sign and density of the charge carriers. We experimentally investigate circuits made from superconductors or graphene to find evidence for this effect.

Stochastic inflation in phase space: is slow roll a stochastic attractor?

DOE Office of Scientific and Technical Information (OSTI.GOV)

Grain, Julien; Vennin, Vincent, E-mail: julien.grain@ias.u-psud.fr, E-mail: vincent.vennin@port.ac.uk

An appealing feature of inflationary cosmology is the presence of a phase-space attractor, ''slow roll'', which washes out the dependence on initial field velocities. We investigate the robustness of this property under backreaction from quantum fluctuations using the stochastic inflation formalism in the phase-space approach. A Hamiltonian formulation of stochastic inflation is presented, where it is shown that the coarse-graining procedure—where wavelengths smaller than the Hubble radius are integrated out—preserves the canonical structure of free fields. This means that different sets of canonical variables give rise to the same probability distribution which clarifies the literature with respect to this issue.more » The role played by the quantum-to-classical transition is also analysed and is shown to constrain the coarse-graining scale. In the case of free fields, we find that quantum diffusion is aligned in phase space with the slow-roll direction. This implies that the classical slow-roll attractor is immune to stochastic effects and thus generalises to a stochastic attractor regardless of initial conditions, with a relaxation time at least as short as in the classical system. For non-test fields or for test fields with non-linear self interactions however, quantum diffusion and the classical slow-roll flow are misaligned. We derive a condition on the coarse-graining scale so that observational corrections from this misalignment are negligible at leading order in slow roll.« less

Colour Constancy Beyond the Classical Receptive Field.

PubMed

Akbarinia, Arash; Parraga, C Alejandro

2017-09-18

The problem of removing illuminant variations to preserve the colours of objects (colour constancy) has already been solved by the human brain using mechanisms that rely largely on centre-surround computations of local contrast. In this paper we adopt some of these biological solutions described by long known physiological findings into a simple, fully automatic, functional model (termed Adaptive Surround Modulation or ASM). In ASM, the size of a visual neuron's receptive field (RF) as well as the relationship with its surround varies according to the local contrast within the stimulus, which in turn determines the nature of the centre-surround normalisation of cortical neurons higher up in the processing chain. We modelled colour constancy by means of two overlapping asymmetric Gaussian kernels whose sizes are adapted based on the contrast of the surround pixels, resembling the change of RF size. We simulated the contrast-dependent surround modulation by weighting the contribution of each Gaussian according to the centre-surround contrast. In the end, we obtained an estimation of the illuminant from the set of the most activated RFs' outputs. Our results on three single-illuminant and one multi-illuminant benchmark datasets show that ASM is highly competitive against the state-of-the-art and it even outperforms learning-based algorithms in one case. Moreover, the robustness of our model is more tangible if we consider that our results were obtained using the same parameters for all datasets, that is, mimicking how the human visual system operates. These results might provide an insight on how dynamical adaptation mechanisms contribute to make object's colours appear constant to us.

A divide and conquer approach to cope with uncertainty, human health risk, and decision making in contaminant hydrology

NASA Astrophysics Data System (ADS)

de Barros, Felipe P. J.; Bolster, Diogo; Sanchez-Vila, Xavier; Nowak, Wolfgang

2011-05-01

Assessing health risk in hydrological systems is an interdisciplinary field. It relies on the expertise in the fields of hydrology and public health and needs powerful translation concepts to provide decision support and policy making. Reliable health risk estimates need to account for the uncertainties and variabilities present in hydrological, physiological, and human behavioral parameters. Despite significant theoretical advancements in stochastic hydrology, there is still a dire need to further propagate these concepts to practical problems and to society in general. Following a recent line of work, we use fault trees to address the task of probabilistic risk analysis and to support related decision and management problems. Fault trees allow us to decompose the assessment of health risk into individual manageable modules, thus tackling a complex system by a structural divide and conquer approach. The complexity within each module can be chosen individually according to data availability, parsimony, relative importance, and stage of analysis. Three differences are highlighted in this paper when compared to previous works: (1) The fault tree proposed here accounts for the uncertainty in both hydrological and health components, (2) system failure within the fault tree is defined in terms of risk being above a threshold value, whereas previous studies that used fault trees used auxiliary events such as exceedance of critical concentration levels, and (3) we introduce a new form of stochastic fault tree that allows us to weaken the assumption of independent subsystems that is required by a classical fault tree approach. We illustrate our concept in a simple groundwater-related setting.

Teaching the Classics: The "Origin of Species" as a Case Study

ERIC Educational Resources Information Center

Ruse, Michael

2013-01-01

Many (including the author) argue that reading the classics in the field should be part of a scientist's education. However, how you read the classics can be very different depending on whether you read them as a historian or as a practicing scientist. This point will be made by comparing two readings of Charles Darwin's "Origin of…

Plasma Heating and Ultrafast Semiconductor Laser Modulation Through a Terahertz Heating Field

NASA Technical Reports Server (NTRS)

Li, Jian-Zhong; Ning, C. Z.

2000-01-01

Electron-hole plasma heating and ultrafast modulation in a semiconductor laser under a terahertz electrical field are investigated using a set of hydrodynamic equations derived from the semiconductor Bloch equations. The self-consistent treatment of lasing and heating processes leads to the prediction of a strong saturation and degradation of modulation depth even at moderate terahertz field intensity. This saturation places a severe limit to bandwidth achievable with such scheme in ultrafast modulation. Strategies for increasing modulation depth are discussed.

New aspects of grassland recovery in old-fields revealed by trait-based analyses of perennial-crop-mediated succession.

PubMed

Kelemen, András; Tóthmérész, Béla; Valkó, Orsolya; Miglécz, Tamás; Deák, Balázs; Török, Péter

2017-04-01

Classical old-field succession studies focused on vegetation changes after the abandonment of annual croplands or on succession after the elimination of cultivated crops. Perennial-crop-mediated succession, where fields are initially covered by perennial crops, reveals alternative aspects of old-field succession theories. We tested the validity of classical theories of old-field succession for perennial-crop-mediated succession. We formulated the following hypotheses: (1) functional diversity increases with increasing field age; (2) resource acquisition versus conservation trade-off shifts toward conservation at community level during the succession; (3) the importance of spatial and temporal seed dispersal decreases during the succession; and (4) competitiveness and stress-tolerance increases and ruderality decreases at community level during the succession. We studied functional diversity, trait distributions and plant strategies in differently aged old-fields using chronosequence method. We found increasing functional richness and functional divergence, but also unchanged or decreasing functional evenness. We detected a shift from resource acquisition to resource conservation strategy of communities during the succession. The role of spatial and temporal seed dispersal was found to be important not only at the initial but also at latter successional stages. We found an increasing stress-tolerance and a decreasing ruderality during succession, while the competitiveness remained unchanged at the community level. Despite the markedly different starting conditions, we found that classical and perennial-crop-mediated old-field successions have some similarities regarding the changes of functional diversity, resource acquisition versus conservation trade-off, and seed dispersal strategies. However, we revealed also the subsequent differences. The competitive character of communities remained stable during the succession; hence, the initial stages of perennial-crop-mediated succession can be similar to the middle stages of classical old-field succession. Moreover, the occupied functional niche space and differentiation were larger in the older stages, but resources were not effectively utilized within this space, suggesting that the stabilization of the vegetation requires more time.

Force-field functor theory: classical force-fields which reproduce equilibrium quantum distributions

PubMed Central

Babbush, Ryan; Parkhill, John; Aspuru-Guzik, Alán

2013-01-01

Feynman and Hibbs were the first to variationally determine an effective potential whose associated classical canonical ensemble approximates the exact quantum partition function. We examine the existence of a map between the local potential and an effective classical potential which matches the exact quantum equilibrium density and partition function. The usefulness of such a mapping rests in its ability to readily improve Born-Oppenheimer potentials for use with classical sampling. We show that such a map is unique and must exist. To explore the feasibility of using this result to improve classical molecular mechanics, we numerically produce a map from a library of randomly generated one-dimensional potential/effective potential pairs then evaluate its performance on independent test problems. We also apply the map to simulate liquid para-hydrogen, finding that the resulting radial pair distribution functions agree well with path integral Monte Carlo simulations. The surprising accessibility and transferability of the technique suggest a quantitative route to adapting Born-Oppenheimer potentials, with a motivation similar in spirit to the powerful ideas and approximations of density functional theory. PMID:24790954

Transport studies in high-performance field reversed configuration plasmas

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gupta, S., E-mail: sgupta@trialphaenergy.com; Barnes, D. C.; Dettrick, S. A.

2016-05-15

A significant improvement of field reversed configuration (FRC) lifetime and plasma confinement times in the C-2 plasma, called High Performance FRC regime, has been observed with neutral beam injection (NBI), improved edge stability, and better wall conditioning [Binderbauer et al., Phys. Plasmas 22, 056110 (2015)]. A Quasi-1D (Q1D) fluid transport code has been developed and employed to carry out transport analysis of such C-2 plasma conditions. The Q1D code is coupled to a Monte-Carlo code to incorporate the effect of fast ions, due to NBI, on the background FRC plasma. Numerically, the Q1D transport behavior with enhanced transport coefficients (butmore » with otherwise classical parametric dependencies) such as 5 times classical resistive diffusion, classical thermal ion conductivity, 20 times classical electron thermal conductivity, and classical fast ion behavior fit with the experimentally measured time evolution of the excluded flux radius, line-integrated density, and electron/ion temperature. The numerical study shows near sustainment of poloidal flux for nearly 1 ms in the presence of NBI.« less

Polarizable Force Field for DNA Based on the Classical Drude Oscillator: I. Refinement Using Quantum Mechanical Base Stacking and Conformational Energetics.

PubMed

Lemkul, Justin A; MacKerell, Alexander D

2017-05-09

Empirical force fields seek to relate the configuration of a set of atoms to its energy, thus yielding the forces governing its dynamics, using classical physics rather than more expensive quantum mechanical calculations that are computationally intractable for large systems. Most force fields used to simulate biomolecular systems use fixed atomic partial charges, neglecting the influence of electronic polarization, instead making use of a mean-field approximation that may not be transferable across environments. Recent hardware and software developments make polarizable simulations feasible, and to this end, polarizable force fields represent the next generation of molecular dynamics simulation technology. In this work, we describe the refinement of a polarizable force field for DNA based on the classical Drude oscillator model by targeting quantum mechanical interaction energies and conformational energy profiles of model compounds necessary to build a complete DNA force field. The parametrization strategy employed in the present work seeks to correct weak base stacking in A- and B-DNA and the unwinding of Z-DNA observed in the previous version of the force field, called Drude-2013. Refinement of base nonbonded terms and reparametrization of dihedral terms in the glycosidic linkage, deoxyribofuranose rings, and important backbone torsions resulted in improved agreement with quantum mechanical potential energy surfaces. Notably, we expand on previous efforts by explicitly including Z-DNA conformational energetics in the refinement.

Three waves for quantum gravity

NASA Astrophysics Data System (ADS)

Calmet, Xavier; Latosh, Boris

2018-03-01

Using effective field theoretical methods, we show that besides the already observed gravitational waves, quantum gravity predicts two further massive classical fields leading to two new massive waves. We set a limit on the masses of these new modes using data from the Eöt-Wash experiment. We point out that the existence of these new states is a model independent prediction of quantum gravity. We then explain how these new classical fields could impact astrophysical processes and in particular the binary inspirals of neutron stars or black holes. We calculate the emission rate of these new states in binary inspirals astrophysical processes.

Against dogma: On superluminal propagation in classical electromagnetism

NASA Astrophysics Data System (ADS)

Weatherall, James Owen

2014-11-01

It is deeply entrenched dogma that relativity theory prohibits superluminal propagation. It is also experimentally well-established that under some circumstances, classical electromagnetic fields propagate through a dielectric medium with superluminal group velocities and superluminal phase velocities. But it is usually claimed that these superluminal velocities do not violate the relativistic prohibition. Here I analyze electromagnetic fields in a dielectric medium within a framework for understanding superluminal propagation recently developed by Geroch (1996, 2011) and elaborated by Earman (2014). I will argue that for some parameter values, electromagnetic fields do propagate superluminally in the Geroch-Earman sense.

Comparison of adaptive critic-based and classical wide-area controllers for power systems.

PubMed

Ray, Swakshar; Venayagamoorthy, Ganesh Kumar; Chaudhuri, Balarko; Majumder, Rajat

2008-08-01

An adaptive critic design (ACD)-based damping controller is developed for a thyristor-controlled series capacitor (TCSC) installed in a power system with multiple poorly damped interarea modes. The performance of this ACD computational intelligence-based method is compared with two classical techniques, which are observer-based state-feedback (SF) control and linear matrix inequality LMI-H(infinity) robust control. Remote measurements are used as feedback signals to the wide-area damping controller for modulating the compensation of the TCSC. The classical methods use a linearized model of the system whereas the ACD method is purely measurement-based, leading to a nonlinear controller with fixed parameters. A comparative analysis of the controllers' performances is carried out under different disturbance scenarios. The ACD-based design has shown promising performance with very little knowledge of the system compared to classical model-based controllers. This paper also discusses the advantages and disadvantages of ACDs, SF, and LMI-H(infinity).

Evaluation of parameters for particles acceleration by the zero-point field of quantum electrodynamics

NASA Technical Reports Server (NTRS)

Rueda, A.

1985-01-01

That particles may be accelerated by vacuum effects in quantum field theory has been repeatedly proposed in the last few years. A natural upshot of this is a mechanism for cosmic rays (CR) primaries acceleration. A mechanism for acceleration by the zero-point field (ZPE) when the ZPE is taken in a realistic sense (in opposition to a virtual field) was considered. Originally the idea was developed within a semiclassical context. The classical Einstein-Hopf model (EHM) was used to show that free isolated electromagnrtically interacting particles performed a random walk in phase space and more importantly in momentum space when submitted to the perennial action of the so called classical electromagnrtic ZPE.

Anomalous Quantum Correlations of Squeezed Light

NASA Astrophysics Data System (ADS)

Kühn, B.; Vogel, W.; Mraz, M.; Köhnke, S.; Hage, B.

2017-04-01

Three different noise moments of field strength, intensity, and their correlations are simultaneously measured. For this purpose a homodyne cross-correlation measurement [1] is implemented by superimposing the signal field and a weak local oscillator on an unbalanced beam splitter. The relevant information is obtained via the intensity noise correlation of the output modes. Detection details like quantum efficiencies or uncorrelated dark noise are meaningless for our technique. Yet unknown insight in the quantumness of a squeezed signal field is retrieved from the anomalous moment, correlating field strength with intensity noise. A classical inequality including this moment is violated for almost all signal phases. Precognition on quantum theory is superfluous, as our analysis is solely based on classical physics.

Electrons in strong electromagnetic fields: spin effects and radiation reaction (Conference Presentation)

NASA Astrophysics Data System (ADS)

Bauke, Heiko; Wen, Meng; Keitel, Christoph H.

2017-05-01

Various different classical models of electrons including their spin degree of freedom are commonly applied to describe the coupled dynamics of relativistic electron motion and spin precession in strong electromagnetic fields. The spin dynamics is usually governed by the Thomas-Bargmann-Michel-Telegdi equation [1, 2] in these models, while the electron's orbital motion follows the (modified) Lorentz force and a spin-dependent Stern-Gerlach force. Various classical models can lead to different or even contradicting predictions how the spin degree of freedom modifies the electron's orbital motion when the electron moves in strong electromagnetic fields. This discrepancy is rooted in the model-specific energy dependency of the spin induced relativistic Stern-Gerlach force acting on the electron. The Frenkel model [3, 4] and the classical Foldy-Wouthuysen model 5 are compared exemplarily against each other and against the quantum mechanical Dirac equation in order to identify parameter regimes where these classical models make different predictions [6, 7]. Our theoretical results allow for experimental tests of these models. In the setup of the longitudinal Stern-Gerlach effect, the Frenkel model and classical Foldy-Wouthuysen model lead in the relativistic limit to qualitatively different spin effects on the electron trajectory. Furthermore, it is demonstrated that in tightly focused beams in the near infrared the effect of the Stern-Gerlach force of the Frenkel model becomes sufficiently large to be potentially detectable in an experiment. Among the classical spin models, the Frenkel model is certainly prominent for its long history and its wide application. Our results, however, suggest that the classical Foldy-Wouthuysen model is superior as it is qualitatively in better agreement with the quantum mechanical Dirac equation. In ultra strong laser setups at parameter regimes where effects of the Stern-Gerlach force become relevant also radiation reaction effects are expected to set in. We incorporate radiation reaction classically via the Landau-Lifshitz equation and demonstrate that although radiation reaction effects can have a significant effect on the electron trajectory, the Frenkel model and the classical Foldy-Wouthuysen model remain distinguishable also if radiation reaction effects are taken into account. Our calculations are also suitable to verify the Landau-Lifshitz equation for the radiation reaction of electrons and other spin one-half particles. 1. Thomas, L. H., "I. The kinematics of an electron with an axis," The London, Edinburgh, and Dublin Philosophical Magazine and Journal of Science 3(13), 1-22 (1927). 2. Bargmann, V., Michel, L., and Telegdi, V. L., "Precession of the polarization of particles moving in a homogeneous electromagnetic field," Phys. Rev. Lett. 2(10), 435-436 (1959). 3. Frenkel, J., "Die Elektrodynamik des rotierenden Elektrons," Z. Phys. 37(4-5), 243-262 (1926). 4. Frenkel, J., "Spinning electrons," Nature (London) 117(2949), 653-654 (1926). 5. Silenko, A. J., "Foldy-Wouthyusen transformation and semiclassical limit for relativistic particles in strong external fields," Phys. Rev. A 77(1), 012116 (2008). 6. Wen, M., Bauke, H., and Keitel, C. H., "Identifying the Stern-Gerlach force of classical electron dynamics," Sci. Rep. 6, 31624 (2016). 7. Wen, M., Keitel, C. H., and Bauke, H., "Spin one-half particles in strong electromagnetic fields: spin effects and radiation reaction," arXiv:1610.08951 (2016).

On the relationship between the classical Dicke-Jaynes-Cummings-Gaudin model and the nonlinear Schroedinger equation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Du, Dianlou; Geng, Xue

2013-05-15

In this paper, the relationship between the classical Dicke-Jaynes-Cummings-Gaudin (DJCG) model and the nonlinear Schroedinger (NLS) equation is studied. It is shown that the classical DJCG model is equivalent to a stationary NLS equation. Moreover, the standard NLS equation can be solved by the classical DJCG model and a suitably chosen higher order flow. Further, it is also shown that classical DJCG model can be transformed into the classical Gaudin spin model in an external magnetic field through a deformation of Lax matrix. Finally, the separated variables are constructed on the common level sets of Casimir functions and the generalizedmore » action-angle coordinates are introduced via the Hamilton-Jacobi equation.« less

The Effectiveness of a Virtual Field Trip (VFT) Module in Learning Biology

ERIC Educational Resources Information Center

Haris, Norbaizura; Osman, Kamisah

2015-01-01

Virtual Field Trip is a computer aided module of science developed to study the Colonisation and Succession in Mangrove Swamps, as an alternative to the real field trip in Form for Biology. This study is to identify the effectiveness of the Virtual Field Trip (VFT) module towards the level of achievement in the formative test for this topic. This…

The direct injection of intense ion beams from a high field electron cyclotron resonance ion source into a radio frequency quadrupole

NASA Astrophysics Data System (ADS)

Rodrigues, G.; Becker, R.; Hamm, R. W.; Baskaran, R.; Kanjilal, D.; Roy, A.

2014-02-01

The ion current achievable from high intensity ECR sources for highly charged ions is limited by the high space charge. This makes classical extraction systems for the transport and subsequent matching to a radio frequency quadrupole (RFQ) accelerator less efficient. The direct plasma injection (DPI) method developed originally for the laser ion source avoids these problems and uses the combined focusing of the gap between the ion source and the RFQ vanes (or rods) and the focusing of the rf fields from the RFQ penetrating into this gap. For high performance ECR sources that use superconducting solenoids, the stray magnetic field of the source in addition to the DPI scheme provides focusing against the space charge blow-up of the beam. A combined extraction/matching system has been designed for a high performance ECR ion source injecting into an RFQ, allowing a total beam current of 10 mA from the ion source for the production of highly charged 238U40+ (1.33 mA) to be injected at an ion source voltage of 60 kV. In this design, the features of IGUN have been used to take into account the rf-focusing of an RFQ channel (without modulation), the electrostatic field between ion source extraction and the RFQ vanes, the magnetic stray field of the ECR superconducting solenoid, and the defocusing space charge of an ion beam. The stray magnetic field is shown to be critical in the case of a matched beam.

The direct injection of intense ion beams from a high field electron cyclotron resonance ion source into a radio frequency quadrupole.

PubMed

Rodrigues, G; Becker, R; Hamm, R W; Baskaran, R; Kanjilal, D; Roy, A

2014-02-01

The ion current achievable from high intensity ECR sources for highly charged ions is limited by the high space charge. This makes classical extraction systems for the transport and subsequent matching to a radio frequency quadrupole (RFQ) accelerator less efficient. The direct plasma injection (DPI) method developed originally for the laser ion source avoids these problems and uses the combined focusing of the gap between the ion source and the RFQ vanes (or rods) and the focusing of the rf fields from the RFQ penetrating into this gap. For high performance ECR sources that use superconducting solenoids, the stray magnetic field of the source in addition to the DPI scheme provides focusing against the space charge blow-up of the beam. A combined extraction/matching system has been designed for a high performance ECR ion source injecting into an RFQ, allowing a total beam current of 10 mA from the ion source for the production of highly charged (238)U(40+) (1.33 mA) to be injected at an ion source voltage of 60 kV. In this design, the features of IGUN have been used to take into account the rf-focusing of an RFQ channel (without modulation), the electrostatic field between ion source extraction and the RFQ vanes, the magnetic stray field of the ECR superconducting solenoid, and the defocusing space charge of an ion beam. The stray magnetic field is shown to be critical in the case of a matched beam.

An algebra of reversible computation.

PubMed

Wang, Yong

2016-01-01

We design an axiomatization for reversible computation called reversible ACP (RACP). It has four extendible modules: basic reversible processes algebra, algebra of reversible communicating processes, recursion and abstraction. Just like process algebra ACP in classical computing, RACP can be treated as an axiomatization foundation for reversible computation.

Scale invariance in chaotic time series: Classical and quantum examples

NASA Astrophysics Data System (ADS)

Landa, Emmanuel; Morales, Irving O.; Stránský, Pavel; Fossion, Rubén; Velázquez, Victor; López Vieyra, J. C.; Frank, Alejandro

Important aspects of chaotic behavior appear in systems of low dimension, as illustrated by the Map Module 1. It is indeed a remarkable fact that all systems tha make a transition from order to disorder display common properties, irrespective of their exacta functional form. We discuss evidence for 1/f power spectra in the chaotic time series associated in classical and quantum examples, the one-dimensional map module 1 and the spectrum of 48Ca. A Detrended Fluctuation Analysis (DFA) method is applied to investigate the scaling properties of the energy fluctuations in the spectrum of 48Ca obtained with a large realistic shell model calculation (ANTOINE code) and with a random shell model (TBRE) calculation also in the time series obtained with the map mod 1. We compare the scale invariant properties of the 48Ca nuclear spectrum sith similar analyses applied to the RMT ensambles GOE and GDE. A comparison with the corresponding power spectra is made in both cases. The possible consequences of the results are discussed.

Performance of extended Lagrangian schemes for molecular dynamics simulations with classical polarizable force fields and density functional theory

NASA Astrophysics Data System (ADS)

Vitale, Valerio; Dziedzic, Jacek; Albaugh, Alex; Niklasson, Anders M. N.; Head-Gordon, Teresa; Skylaris, Chris-Kriton

2017-03-01

Iterative energy minimization with the aim of achieving self-consistency is a common feature of Born-Oppenheimer molecular dynamics (BOMD) and classical molecular dynamics with polarizable force fields. In the former, the electronic degrees of freedom are optimized, while the latter often involves an iterative determination of induced point dipoles. The computational effort of the self-consistency procedure can be reduced by re-using converged solutions from previous time steps. However, this must be done carefully, as not to break time-reversal symmetry, which negatively impacts energy conservation. Self-consistent schemes based on the extended Lagrangian formalism, where the initial guesses for the optimized quantities are treated as auxiliary degrees of freedom, constitute one elegant solution. We report on the performance of two integration schemes with the same underlying extended Lagrangian structure, which we both employ in two radically distinct regimes—in classical molecular dynamics simulations with the AMOEBA polarizable force field and in BOMD simulations with the Onetep linear-scaling density functional theory (LS-DFT) approach. Both integration schemes are found to offer significant improvements over the standard (unpropagated) molecular dynamics formulation in both the classical and LS-DFT regimes.

Performance of extended Lagrangian schemes for molecular dynamics simulations with classical polarizable force fields and density functional theory.

PubMed

Vitale, Valerio; Dziedzic, Jacek; Albaugh, Alex; Niklasson, Anders M N; Head-Gordon, Teresa; Skylaris, Chris-Kriton

2017-03-28

Iterative energy minimization with the aim of achieving self-consistency is a common feature of Born-Oppenheimer molecular dynamics (BOMD) and classical molecular dynamics with polarizable force fields. In the former, the electronic degrees of freedom are optimized, while the latter often involves an iterative determination of induced point dipoles. The computational effort of the self-consistency procedure can be reduced by re-using converged solutions from previous time steps. However, this must be done carefully, as not to break time-reversal symmetry, which negatively impacts energy conservation. Self-consistent schemes based on the extended Lagrangian formalism, where the initial guesses for the optimized quantities are treated as auxiliary degrees of freedom, constitute one elegant solution. We report on the performance of two integration schemes with the same underlying extended Lagrangian structure, which we both employ in two radically distinct regimes-in classical molecular dynamics simulations with the AMOEBA polarizable force field and in BOMD simulations with the Onetep linear-scaling density functional theory (LS-DFT) approach. Both integration schemes are found to offer significant improvements over the standard (unpropagated) molecular dynamics formulation in both the classical and LS-DFT regimes.

Performance of extended Lagrangian schemes for molecular dynamics simulations with classical polarizable force fields and density functional theory

DOE PAGES

Vitale, Valerio; Dziedzic, Jacek; Albaugh, Alex; ...

2017-03-28

Iterative energy minimization with the aim of achieving self-consistency is a common feature of Born-Oppenheimer molecular dynamics (BOMD) and classical molecular dynamics with polarizable force fields. In the former, the electronic degrees of freedom are optimized, while the latter often involves an iterative determination of induced point dipoles. The computational effort of the self-consistency procedure can be reduced by re-using converged solutions from previous time steps. However, this must be done carefully, as not to break time-reversal symmetry, which negatively impacts energy conservation. Self-consistent schemes based on the extended Lagrangian formalism, where the initial guesses for the optimized quantities aremore » treated as auxiliary degrees of freedom, constitute one elegant solution. We report on the performance of two integration schemes with the same underlying extended Lagrangian structure, which we both employ in two radically distinct regimes—in classical molecular dynamics simulations with the AMOEBA polarizable force field and in BOMD simulations with the Onetep linear-scaling density functional theory (LS-DFT) approach. Furthermore, both integration schemes are found to offer significant improvements over the standard (unpropagated) molecular dynamics formulation in both the classical and LS-DFT regimes.« less

Performance of extended Lagrangian schemes for molecular dynamics simulations with classical polarizable force fields and density functional theory

DOE Office of Scientific and Technical Information (OSTI.GOV)

Vitale, Valerio; Dziedzic, Jacek; Albaugh, Alex

Iterative energy minimization with the aim of achieving self-consistency is a common feature of Born-Oppenheimer molecular dynamics (BOMD) and classical molecular dynamics with polarizable force fields. In the former, the electronic degrees of freedom are optimized, while the latter often involves an iterative determination of induced point dipoles. The computational effort of the self-consistency procedure can be reduced by re-using converged solutions from previous time steps. However, this must be done carefully, as not to break time-reversal symmetry, which negatively impacts energy conservation. Self-consistent schemes based on the extended Lagrangian formalism, where the initial guesses for the optimized quantities aremore » treated as auxiliary degrees of freedom, constitute one elegant solution. We report on the performance of two integration schemes with the same underlying extended Lagrangian structure, which we both employ in two radically distinct regimes—in classical molecular dynamics simulations with the AMOEBA polarizable force field and in BOMD simulations with the Onetep linear-scaling density functional theory (LS-DFT) approach. Furthermore, both integration schemes are found to offer significant improvements over the standard (unpropagated) molecular dynamics formulation in both the classical and LS-DFT regimes.« less

Quantum localization of classical mechanics

NASA Astrophysics Data System (ADS)

Batalin, Igor A.; Lavrov, Peter M.

2016-07-01

Quantum localization of classical mechanics within the BRST-BFV and BV (or field-antifield) quantization methods are studied. It is shown that a special choice of gauge fixing functions (or BRST-BFV charge) together with the unitary limit leads to Hamiltonian localization in the path integral of the BRST-BFV formalism. In turn, we find that a special choice of gauge fixing functions being proportional to extremals of an initial non-degenerate classical action together with a very special solution of the classical master equation result in Lagrangian localization in the partition function of the BV formalism.

Non-local classical optical correlation and implementing analogy of quantum teleportation

PubMed Central

Sun, Yifan; Song, Xinbing; Qin, Hongwei; Zhang, Xiong; Yang, Zhenwei; Zhang, Xiangdong

2015-01-01

This study reports an experimental realization of non-local classical optical correlation from the Bell's measurement used in tests of quantum non-locality. Based on such a classical Einstein–Podolsky–Rosen optical correlation, a classical analogy has been implemented to the true meaning of quantum teleportation. In the experimental teleportation protocol, the initial teleported information can be unknown to anyone and the information transfer can happen over arbitrary distances. The obtained results give novel insight into quantum physics and may open a new field of applications in quantum information. PMID:25779977

The influences and neural correlates of past and present during gambling in humans.

PubMed

Sacré, Pierre; Subramanian, Sandya; Kerr, Matthew S D; Kahn, Kevin; Johnson, Matthew A; Bulacio, Juan; González-Martínez, Jorge A; Sarma, Sridevi V; Gale, John T

2017-12-07

During financial decision-making tasks, humans often make "rational" decisions, where they maximize expected reward. However, this rationality may compete with a bias that reflects past outcomes. That is, if one just lost money or won money, this may impact future decisions. It is unclear how past outcomes influence future decisions in humans, and how neural circuits encode present and past information. In this study, six human subjects performed a financial decision-making task while we recorded local field potentials from multiple brain structures. We constructed a model for each subject characterizing bets on each trial as a function of present and past information. The models suggest that some patients are more influenced by previous trial outcomes (i.e., previous return and risk) than others who stick to more fixed decision strategies. In addition, past return and present risk modulated with the activity in the cuneus; while present return and past risk modulated with the activity in the superior temporal gyrus and the angular gyrus, respectively. Our findings suggest that these structures play a role in decision-making beyond their classical functions by incorporating predictions and risks in humans' decision strategy, and provide new insight into how humans link their internal biases to decisions.

Melatonin, Noncoding RNAs, Messenger RNA Stability and Epigenetics—Evidence, Hints, Gaps and Perspectives

PubMed Central

Hardeland, Rüdiger

2014-01-01

Melatonin is a highly pleiotropic regulator molecule, which influences numerous functions in almost every organ and, thus, up- or down-regulates many genes, frequently in a circadian manner. Our understanding of the mechanisms controlling gene expression is actually now expanding to a previously unforeseen extent. In addition to classic actions of transcription factors, gene expression is induced, suppressed or modulated by a number of RNAs and proteins, such as miRNAs, lncRNAs, piRNAs, antisense transcripts, deadenylases, DNA methyltransferases, histone methylation complexes, histone demethylases, histone acetyltransferases and histone deacetylases. Direct or indirect evidence for involvement of melatonin in this network of players has originated in different fields, including studies on central and peripheral circadian oscillators, shift work, cancer, inflammation, oxidative stress, aging, energy expenditure/obesity, diabetes type 2, neuropsychiatric disorders, and neurogenesis. Some of the novel modulators have also been shown to participate in the control of melatonin biosynthesis and melatonin receptor expression. Future work will need to augment the body of evidence on direct epigenetic actions of melatonin and to systematically investigate its role within the network of oscillating epigenetic factors. Moreover, it will be necessary to discriminate between effects observed under conditions of well-operating and deregulated circadian clocks, and to explore the possibilities of correcting epigenetic malprogramming by melatonin. PMID:25310649

Optimizations of a Hardware Decoder for Deep-Space Optical Communications

NASA Technical Reports Server (NTRS)

Cheng, Michael K.; Nakashima, Michael A.; Moision, Bruce E.; Hamkins, Jon

2007-01-01

The National Aeronautics and Space Administration has developed a capacity approaching modulation and coding scheme that comprises a serial concatenation of an inner accumulate pulse-position modulation (PPM) and an outer convolutional code [or serially concatenated PPM (SCPPM)] for deep-space optical communications. Decoding of this code uses the turbo principle. However, due to the nonbinary property of SCPPM, a straightforward application of classical turbo decoding is very inefficient. Here, we present various optimizations applicable in hardware implementation of the SCPPM decoder. More specifically, we feature a Super Gamma computation to efficiently handle parallel trellis edges, a pipeline-friendly 'maxstar top-2' circuit that reduces the max-only approximation penalty, a low-latency cyclic redundancy check circuit for window-based decoders, and a high-speed algorithmic polynomial interleaver that leads to memory savings. Using the featured optimizations, we implement a 6.72 megabits-per-second (Mbps) SCPPM decoder on a single field-programmable gate array (FPGA). Compared to the current data rate of 256 kilobits per second from Mars, the SCPPM coded scheme represents a throughput increase of more than twenty-six fold. Extension to a 50-Mbps decoder on a board with multiple FPGAs follows naturally. We show through hardware simulations that the SCPPM coded system can operate within 1 dB of the Shannon capacity at nominal operating conditions.

Novel applications of photonic signal processing: Temporal cloaking and biphoton pulse shaping

NASA Astrophysics Data System (ADS)

Lukens, Joseph M.

We experimentally demonstrate two innovative applications of photonic technologies previously solidified in the field of classical optical communications. In the first application, we exploit electro-optic modulator technology to develop a novel "time cloak,'' a device which hides events in time by manipulating the flow of a probing light beam. Our temporal cloak is capable of masking high-speed optical data from a receiver, greatly improving the feasibility of time cloaking and bringing such exotic concepts to the verge of practical application. In the second specialization, high-resolution Fourier-transform pulse shaping---perfected for multi-wavelength telecom networks---is applied to shape the correlations of entangled photon pairs, states which have received considerable attention in nonlocal tests of quantum theory and in quantum key distribution. Using nonlinear waveguides fabricated out of periodically poled lithium niobate, we are able to demonstrate ultrafast coincidence detection with record-high efficiency, which coupled with our pulse shaper allows us to realize for the first time several capabilities in biphoton control, including high-order dispersion cancellation, orthogonal spectral coding, correlation train generation, and tunable delay control. Each of these experiments represents an important advance in quantum state manipulation, with the potential to impact developments in quantum information. And more generally, our work introducing telecommunication technology into both temporal cloaking and biphoton control highlights the potential of such tools in more nascent outgrowths of classical and quantum optics.

Power-law modulation of the scalar power spectrum from a heavy field with a monomial potential

NASA Astrophysics Data System (ADS)

Huang, Qing-Guo; Pi, Shi

2018-04-01

The effects of heavy fields modulate the scalar power spectrum during inflation. We analytically calculate the modulations of the scalar power spectrum from a heavy field with a separable monomial potential, i.e. V(phi)~ phin. In general the modulation is characterized by a power-law oscillation which is reduced to the logarithmic oscillation in the case of n=2.

Space-by-Time Modular Decomposition Effectively Describes Whole-Body Muscle Activity During Upright Reaching in Various Directions

PubMed Central

Hilt, Pauline M.; Delis, Ioannis; Pozzo, Thierry; Berret, Bastien

2018-01-01

The modular control hypothesis suggests that motor commands are built from precoded modules whose specific combined recruitment can allow the performance of virtually any motor task. Despite considerable experimental support, this hypothesis remains tentative as classical findings of reduced dimensionality in muscle activity may also result from other constraints (biomechanical couplings, data averaging or low dimensionality of motor tasks). Here we assessed the effectiveness of modularity in describing muscle activity in a comprehensive experiment comprising 72 distinct point-to-point whole-body movements during which the activity of 30 muscles was recorded. To identify invariant modules of a temporal and spatial nature, we used a space-by-time decomposition of muscle activity that has been shown to encompass classical modularity models. To examine the decompositions, we focused not only on the amount of variance they explained but also on whether the task performed on each trial could be decoded from the single-trial activations of modules. For the sake of comparison, we confronted these scores to the scores obtained from alternative non-modular descriptions of the muscle data. We found that the space-by-time decomposition was effective in terms of data approximation and task discrimination at comparable reduction of dimensionality. These findings show that few spatial and temporal modules give a compact yet approximate representation of muscle patterns carrying nearly all task-relevant information for a variety of whole-body reaching movements. PMID:29666576

Opening Switch Research on a Plasma Focus VI.

DTIC Science & Technology

1988-02-26

Sausage Instability in the Plasma Focus In this section the classical Kruskal- Schwarzschild 3 theory for the sausage mode is applied to the pinch phase...on 1) the shape of the pinch, 2) axial flow of plasma, and 3) self-generated magnetic fields are also presented. The Kruskal- Schwarzschild Theory The...classical mhd theory for the m=O mode in a plasma supported by a magnetic field against gravity; this is the well-known Kruskal- Schwarzschild

Quantum algorithm for energy matching in hard optimization problems

NASA Astrophysics Data System (ADS)

Baldwin, C. L.; Laumann, C. R.

2018-06-01

We consider the ability of local quantum dynamics to solve the "energy-matching" problem: given an instance of a classical optimization problem and a low-energy state, find another macroscopically distinct low-energy state. Energy matching is difficult in rugged optimization landscapes, as the given state provides little information about the distant topography. Here, we show that the introduction of quantum dynamics can provide a speedup over classical algorithms in a large class of hard optimization problems. Tunneling allows the system to explore the optimization landscape while approximately conserving the classical energy, even in the presence of large barriers. Specifically, we study energy matching in the random p -spin model of spin-glass theory. Using perturbation theory and exact diagonalization, we show that introducing a transverse field leads to three sharp dynamical phases, only one of which solves the matching problem: (1) a small-field "trapped" phase, in which tunneling is too weak for the system to escape the vicinity of the initial state; (2) a large-field "excited" phase, in which the field excites the system into high-energy states, effectively forgetting the initial energy; and (3) the intermediate "tunneling" phase, in which the system succeeds at energy matching. The rate at which distant states are found in the tunneling phase, although exponentially slow in system size, is exponentially faster than classical search algorithms.

International field testing of the psychometric properties of an EORTC quality of life module for oral health: the EORTC QLQ-OH15.

PubMed

Hjermstad, Marianne J; Bergenmar, Mia; Bjordal, Kristin; Fisher, Sheila E; Hofmeister, Dirk; Montel, Sébastien; Nicolatou-Galitis, Ourania; Pinto, Monica; Raber-Durlacher, Judith; Singer, Susanne; Tomaszewska, Iwona M; Tomaszewski, Krzysztof A; Verdonck-de Leeuw, Irma; Yarom, Noam; Winstanley, Julie B; Herlofson, Bente B

2016-09-01

This international EORTC validation study (phase IV) is aimed at testing the psychometric properties of a quality of life (QoL) module related to oral health problems in cancer patients. The phase III module comprised 17 items with four hypothesized multi-item scales and three single items. In phase IV, patients with mixed cancers, in different treatment phases from 10 countries completed the EORTC QLQ-C30, the QLQ-OH module, and a debriefing interview. The hypothesized structure was tested using combinations of classical test theory and item response theory, following EORTC guidelines. Test-retest assessments and responsiveness to change analysis (RCA) were performed after 2 weeks. Five hundred seventy-two patients (median age 60.3, 54 % females) were analyzed. Completion took <10 min for 84 %, 40 % expressed satisfaction that these issues were addressed. Analyses suggested a revision of the phase III hypothesized scale structure. Two items were deleted based on a high degree of item misfit, together with negative patient feedback. The remaining 15 items formed one eight-item scale named OH-QoL score, a two-item information scale, a two-item scale regarding dentures, and three single items (sticky saliva/mouth soreness/sensitivity to food/drink). Face and convergent validity and internal consistency were confirmed. Test-retest reliability (n = 60) was demonstrated as was RCA for patients undergoing chemotherapy (n = 117; p = 0.06). The resulting QLQ-OH15 discriminated between clinically distinct patient groups, e.g., low performance status vs. higher (p < 000.1), and head-and-neck cancer versus other cancers (p < 0.03). The EORTC module QLQ-OH15 is a short, well-accepted assessment tool focusing on oral problems and QoL to improve clinical management. ClinicalTrials.gov Identifier: NCT01724333.

Coherent manipulation of photons and electrons

NASA Astrophysics Data System (ADS)

Zhao, Lu

In modern physics, coherent manipulation of photons and electrons has been intensively studied, and may have important applications in classical and quantum information processing. In this dissertation, we consider some interesting schemes to realize photonic and electronic coherent manipulation. In order to coherently manipulate photons, electromagnetically induced transparency (EIT) systems have been widely adopted because the optical response of EIT systems can be controlled by the laser-induced atomic coherence. In the second chapter, we theoretically investigate image storage in hot-vapor EIT media. A so-called 4f system is adopted for imaging, and an atomic vapor cell is placed over the transform plane. The Fraunhofer diffraction pattern of an object in the object plane can thus be transformed into atomic Raman coherence according to the idea of "light storage". We investigate how the stored diffraction pattern evolves under diffusion and discuss the essence of the stability of its dark spots. Our result indicates under appropriate conditions that an image can be reconstructed with high fidelity. The main reason for this procedure is the fact that diffusion of opposite-phase components of the diffraction pattern interfere destructively. In the third chapter, we show theoretical evidence that EIT systems can function as optically addressed spatial light modulators with megahertz modulation rates. The transverse spatial properties of continuous-wave probe fields can be modulated rapidly using two-dimensional optical patterns. To exemplify our proposal, we study real-time generation and manipulation of Laguerre-Gaussian beams by means of phase or amplitude modulation using flat-top image-bearing pulse trains as coupling fields in low-cost hot-vapor EIT systems. In order to coherently manipulate electrons, we consider graphene systems, including single-layer graphene and bilayer graphene, which have recently attracted considerable attention. Due to the long coherence length and electrically tunable Fermi levels, electrons in graphene systems have some photon-like behaviors, and could be coherently manipulated. Therefore, in the fourth chapter, we theorize that at a sharp electrostatic step potential in graphene massless Dirac fermions can obtain Goos-Hanchen-like shifts under total internal reflection. Also, we study coherent propagation of the quasiparticles along a sharp graphene p-n-p waveguide, and derive novel dispersion relations for the guided modes. Consequently, coherent graphene-based devices, e.g., movable mirrors, buffers and memories, induced only by the electric field effects may be proposed. Finally, we theoretically investigate the coherent propagation of massive chiral fermions along a sharp bilayer graphene p-n-p waveguide, and indicate that the guided quasiparticles can be coherently slowed, stored and retrieved based on tunable electric field effects. Controlling group velocity in the bilayer graphene p-n-p waveguide is accomplished via interband tunneling through the p-n interfaces, and does not depend on the bandgap opening.

Method and split cavity oscillator/modulator to generate pulsed particle beams and electromagnetic fields

DOEpatents

Clark, M. Collins; Coleman, P. Dale; Marder, Barry M.

1993-01-01

A compact device called the split cavity modulator whose self-generated oscillating electromagnetic field converts a steady particle beam into a modulated particle beam. The particle beam experiences both signs of the oscillating electric field during the transit through the split cavity modulator. The modulated particle beam can then be used to generate microwaves at that frequency and through the use of extractors, high efficiency extraction of microwave power is enabled. The modulated beam and the microwave frequency can be varied by the placement of resistive wires at nodes of oscillation within the cavity. The short beam travel length through the cavity permit higher currents because both space charge and pinching limitations are reduced. The need for an applied magnetic field to control the beam has been eliminated.

Method and split cavity oscillator/modulator to generate pulsed particle beams and electromagnetic fields

DOEpatents

Clark, M.C.; Coleman, P.D.; Marder, B.M.

1993-08-10

A compact device called the split cavity modulator whose self-generated oscillating electromagnetic field converts a steady particle beam into a modulated particle beam. The particle beam experiences both signs of the oscillating electric field during the transit through the split cavity modulator. The modulated particle beam can then be used to generate microwaves at that frequency and through the use of extractors, high efficiency extraction of microwave power is enabled. The modulated beam and the microwave frequency can be varied by the placement of resistive wires at nodes of oscillation within the cavity. The short beam travel length through the cavity permit higher currents because both space charge and pinching limitations are reduced. The need for an applied magnetic field to control the beam has been eliminated.

Linear Quantum Systems: Non-Classical States and Robust Stability

DTIC Science & Technology

2016-06-29

quantum linear systems subject to non-classical quantum fields. The major outcomes of this project are (i) derivation of quantum filtering equations for...derivation of quantum filtering equations for systems non-classical input states including single photon states, (ii) determination of how linear...history going back some 50 years, to the birth of modern control theory with Kalman’s foundational work on filtering and LQG optimal control

Terrestrial Laser Scanning and Structure from Motion teaching resources for undergraduate field education courses

NASA Astrophysics Data System (ADS)

Pratt-Sitaula, B. A.; Shervais, K.; Crosby, C. J.; Douglas, B. J.; Niemi, N. A.; Wang, G.; Charlevoix, D. J.

2015-12-01

Fieldwork is an integral part of the geosciences and there is a longstanding tradition of teaching field methods as part of the undergraduate curriculum. As new technology changes the ways in which we scientifically examine the Earth, and as workforce development demands evolve, there is growing interest in introducing these new technologies into field education courses. In collaboration with field education instructors, UNAVCO, the National Science Foundation's geodetic facility, has developed a module of teaching resources to integrate terrestrial lidar scanning into field courses. An NSF facility is well positioned to develop scalable resources that can then be distributed or adapted for broader implementation. The modules can also be accomplished using Structure from Motion methods in place of lidar scanning. Modules goals are for students to be able to: (A) design and conduct a complex TLS survey to address a geologic research question and (B) articulate the societal impetus for answering these research questions and identify why TLS is the appropriate method in some circumstances. The module is comprised of five units: (1) Introduction to survey design, (2) Stratigraphic section analysis, (3) Fault scarp analysis, (4) Geomorphic change detection, (5) Student-led survey design summative assessment. The modules, apart from the Introduction, are independent, thus select modules can be employed in a given field setting. Prototype module materials were developed from the last five years of UNAVCO support of undergraduate field courses. The current versions of the modules were tested in summer 2015 at the Indiana University and University of Michigan field camps. Results show that the majority of students are able to achieve the intended learning goals. Module materials are available on the UNAVCO Education and Community Engagement website.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Breznay, Nicholas P.; Tendulkar, Mihir; Zhang, Li

Here, we study the two-dimensional superconductor-insulator transition (SIT) in thin films of tantalum nitride. At zero magnetic field, films can be disorder-tuned across the SIT by adjusting thickness and film stoichiometry; insulating films exhibit classical hopping transport. Superconducting films exhibit a magnetic-field-tuned SIT, whose insulating ground state at high field appears to be a quantum-corrected metal. Scaling behavior at the field-tuned SIT shows classical percolation critical exponents zν ≈ 1.3, with a corresponding critical field H c << H c2, the upper critical field. The Hall effect exhibits a crossing point near H c, but with a nonuniversal critical valuemore » ρ c xy comparable to the normal-state Hall resistivity. We propose that high-carrier-density metals will always exhibit this pattern of behavior at the boundary between superconducting and (trivially) insulating ground states.« less

Superconductor to weak-insulator transitions in disordered tantalum nitride films

NASA Astrophysics Data System (ADS)

Breznay, Nicholas P.; Tendulkar, Mihir; Zhang, Li; Lee, Sang-Chul; Kapitulnik, Aharon

2017-10-01

We study the two-dimensional superconductor-insulator transition (SIT) in thin films of tantalum nitride. At zero magnetic field, films can be disorder-tuned across the SIT by adjusting thickness and film stoichiometry; insulating films exhibit classical hopping transport. Superconducting films exhibit a magnetic-field-tuned SIT, whose insulating ground state at high field appears to be a quantum-corrected metal. Scaling behavior at the field-tuned SIT shows classical percolation critical exponents z ν ≈1.3 , with a corresponding critical field Hc≪Hc 2 , the upper critical field. The Hall effect exhibits a crossing point near Hc, but with a nonuniversal critical value ρxy c comparable to the normal-state Hall resistivity. We propose that high-carrier-density metals will always exhibit this pattern of behavior at the boundary between superconducting and (trivially) insulating ground states.

Phase-Sensitive Coherence and the Classical-Quantum Boundary in Ghost Imaging

NASA Technical Reports Server (NTRS)

Erkmen, Baris I.; Hardy, Nicholas D.; Venkatraman, Dheera; Wong, Franco N. C.; Shapiro, Jeffrey H.

2011-01-01

The theory of partial coherence has a long and storied history in classical statistical optics. the vast majority of this work addresses fields that are statistically stationary in time, hence their complex envelopes only have phase-insensitive correlations. The quantum optics of squeezed-state generation, however, depends on nonlinear interactions producing baseband field operators with phase-insensitive and phase-sensitive correlations. Utilizing quantum light to enhance imaging has been a topic of considerable current interest, much of it involving biphotons, i.e., streams of entangled-photon pairs. Biphotons have been employed for quantum versions of optical coherence tomography, ghost imaging, holography, and lithography. However, their seemingly quantum features have been mimicked with classical-sate light, questioning wherein lies the classical-quantum boundary. We have shown, for the case of Gaussian-state light, that this boundary is intimately connected to the theory of phase-sensitive partial coherence. Here we present that theory, contrasting it with the familiar case of phase-insensitive partial coherence, and use it to elucidate the classical-quantum boundary of ghost imaging. We show, both theoretically and experimentally, that classical phase-sensitive light produces ghost imaging most closely mimicking those obtained in biphotons, and we derived the spatial resolution, image contrast, and signal-to-noise ratio of a standoff-sensing ghost imager, taking into account target-induced speckle.

Classical and quantum cosmology of minimal massive bigravity

NASA Astrophysics Data System (ADS)

Darabi, F.; Mousavi, M.

2016-10-01

In a Friedmann-Robertson-Walker (FRW) space-time background we study the classical cosmological models in the context of recently proposed theory of nonlinear minimal massive bigravity. We show that in the presence of perfect fluid the classical field equations acquire contribution from the massive graviton as a cosmological term which is positive or negative depending on the dynamical competition between two scale factors of bigravity metrics. We obtain the classical field equations for flat and open universes in the ordinary and Schutz representation of perfect fluid. Focusing on the Schutz representation for flat universe, we find classical solutions exhibiting singularities at early universe with vacuum equation of state. Then, in the Schutz representation, we study the quantum cosmology for flat universe and derive the Schrodinger-Wheeler-DeWitt equation. We find its exact and wave packet solutions and discuss on their properties to show that the initial singularity in the classical solutions can be avoided by quantum cosmology. Similar to the study of Hartle-Hawking no-boundary proposal in the quantum cosmology of de Rham, Gabadadze and Tolley (dRGT) massive gravity, it turns out that the mass of graviton predicted by quantum cosmology of the minimal massive bigravity is large at early universe. This is in agreement with the fact that at early universe the cosmological constant should be large.

Basic characteristics of high-frequency Stark-effect modulation of CO2 lasers.

NASA Technical Reports Server (NTRS)

Claspy, P. C.; Pao, Y. H.

1971-01-01

The molecular Stark effect and its application to the modulation of infrared laser radiation have been investigated both theoretically and experimentally. Using a density matrix approach, a quantum mechanical description of the effect of a time-varying electric field on the absorption coefficient and refractive index of a molecular gas near an absorption line has been formulated. For modulation applications a quantity known as the ?modulation depth' is of prime importance. Theoretical expressions for the frequency dependence of the modulation depth show that the response to the frequency of a time-varying Stark field is separated into a nondispersive and a dispersive region, depending on whether the modulating frequency is less than or greater than the homogeneous absorption linewidth. Experimental results showing nondispersive modulation at frequencies to 30 MHz are presented. In addition it is shown that the response of modulation depth to Stark field amplitude is separated into linear and nonlinear regions, the field at which nonlinearities begin being determined by the absorption spectrum of the molecule being used.

Hamilton-Jacobi theory in multisymplectic classical field theories

NASA Astrophysics Data System (ADS)

de León, Manuel; Prieto-Martínez, Pedro Daniel; Román-Roy, Narciso; Vilariño, Silvia

2017-09-01

The geometric framework for the Hamilton-Jacobi theory developed in the studies of Cariñena et al. [Int. J. Geom. Methods Mod. Phys. 3(7), 1417-1458 (2006)], Cariñena et al. [Int. J. Geom. Methods Mod. Phys. 13(2), 1650017 (2015)], and de León et al. [Variations, Geometry and Physics (Nova Science Publishers, New York, 2009)] is extended for multisymplectic first-order classical field theories. The Hamilton-Jacobi problem is stated for the Lagrangian and the Hamiltonian formalisms of these theories as a particular case of a more general problem, and the classical Hamilton-Jacobi equation for field theories is recovered from this geometrical setting. Particular and complete solutions to these problems are defined and characterized in several equivalent ways in both formalisms, and the equivalence between them is proved. The use of distributions in jet bundles that represent the solutions to the field equations is the fundamental tool in this formulation. Some examples are analyzed and, in particular, the Hamilton-Jacobi equation for non-autonomous mechanical systems is obtained as a special case of our results.

Effective field theory of dissipative fluids (II): classical limit, dynamical KMS symmetry and entropy current

DOE Office of Scientific and Technical Information (OSTI.GOV)

Glorioso, Paolo; Crossley, Michael; Liu, Hong

2017-09-20

Here in this paper we further develop the fluctuating hydrodynamics proposed in a number of ways. We first work out in detail the classical limit of the hydrodynamical action, which exhibits many simplifications. In particular, this enables a transparent formulation of the action in physical spacetime in the presence of arbitrary external fields. It also helps to clarify issues related to field redefinitions and frame choices. We then propose that the action is invariant under a Z2 symmetry to which we refer as the dynamical KMS symmetry. The dynamical KMS symmetry is physically equivalent to the previously proposed local KMSmore » condition in the classical limit, but is more convenient to implement and more general. It is applicable to any states in local equilibrium rather than just thermal density matrix perturbed by external background fields. Finally we elaborate the formulation for a conformal fluid, which contains some new features, and work out the explicit form of the entropy current to second order in derivatives for a neutral conformal fluid.« less

Implementation and validation of an economic module in the Be-FAST model to predict costs generated by livestock disease epidemics: Application to classical swine fever epidemics in Spain.

PubMed

Fernández-Carrión, E; Ivorra, B; Martínez-López, B; Ramos, A M; Sánchez-Vizcaíno, J M

2016-04-01

Be-FAST is a computer program based on a time-spatial stochastic spread mathematical model for studying the transmission of infectious livestock diseases within and between farms. The present work describes a new module integrated into Be-FAST to model the economic consequences of the spreading of classical swine fever (CSF) and other infectious livestock diseases within and between farms. CSF is financially one of the most damaging diseases in the swine industry worldwide. Specifically in Spain, the economic costs in the two last CSF epidemics (1997 and 2001) reached jointly more than 108 million euros. The present analysis suggests that severe CSF epidemics are associated with significant economic costs, approximately 80% of which are related to animal culling. Direct costs associated with control measures are strongly associated with the number of infected farms, while indirect costs are more strongly associated with epidemic duration. The economic model has been validated with economic information around the last outbreaks in Spain. These results suggest that our economic module may be useful for analysing and predicting economic consequences of livestock disease epidemics. Copyright © 2016 Elsevier B.V. All rights reserved.

The learning unit "Orthodontic set-up" as a new-media module in teaching.

PubMed

Asselmeyer, T; Fischer, V; Matthies, H; Schwestka-Polly, R

2004-07-01

The present study examines the extent to which computer-assisted learning units provided independently of place and time are used in self-study as a supplement to the classical classroom instruction of dental students. Indications as to whether such teaching modules improve training in orthodontics should be obtained from this. Attention was focussed on the implementation and evaluation of the "Orthodontic set-up" teaching module, which can be accessed in the Internet and Intranet of the university. The didactic arrangement offered classical university courses in parallel (four lectures on the subjects of occlusion, function, diagnostics, and therapy) in addition to the electronically communicated teaching contents. In addition, intensive supervision during the production of the set-up was guaranteed. The use of this multimedia learning concept was in general assessed positively by 63 surveyed students in the 2002/03 winter semester. The results revealed on the one hand the intensity of use and features of the acquisition of knowledge (use types), and on the other hand, in terms of professional relevance, the contents were found to be well explained, didactically attractive, and understandably presented. However, numerous drawbacks were also mentioned (technical and time problems; qualification deficits). The experience gained in this project should encourage more future investment in the development of alternative university didactic models.

Magnetic field and radial velocities of the star β CrB

NASA Astrophysics Data System (ADS)

Han, Inwoo; Valyavin, G.; Galazutdinov, G.; Plachinda, S.; Butkovskaya, V.; Lee, B. C.; Kim, Kang-Min; Jeong, Gwanghui; Romanyuk, I.; Burlakova, T.

2018-06-01

We present the results of long term high-resolution spectral and spectro-polarimetric observations of the classic spectroscopic binary star β Coronae Borealis, which is also well known for its chemical peculiarity and strong magnetic field. One of the main objectives of these observations was to check some suggestions of the presence of a third low-mass component in the system. Analysing our own radial velocity measurements of β Coronae Borealis obtained between 2004 and 2013 together with other RV and astrometric data taken from literature, we have considerably improved the orbital elements of the star. Using residual RVs obtained after subtracting the orbit from the observed RV, we detected a significant periodic signal consistent with the well known 18.4868 day rotation/magnetic period of the star. The shape of the residual RVs folded with the rotation period exhibits a bimodal structure. In order to clarify the origin of the residual RV variation, we model the RV variation due to rotational modulation Zeeman patterns in the spectral lines of β Coronae Borealis spectra. The results of this analysis and the investigation of chemical inhomogeneities in the spectra of β Coronae Borealis convincingly support the "magnetic" nature of the observed radial velocity variations.

Pharmacotherapy for schizophrenia in postmenopausal women.

PubMed

González-Rodríguez, Alexandre; Seeman, Mary V

2018-06-01

Reduced estrogen levels at menopause mean a loss of the neuroprotection that is conferred, from puberty until menopause, on women with schizophrenia. The postmenopausal stage of schizophrenia requires therapeutic attention because women with this diagnosis almost invariably experience increased symptoms and increased side effects at this time. So far, few targeted therapies have been successfully developed. Areas covered: This non-systematic, narrative review is based on the relevant published literature indexed in PubMed. A digital search was combined with a manual check of references from studies in the field of gender differences, menopause and schizophrenia. Aside from the inclusion of a few early classic papers, the review focuses on 21st century basic, psychopharmacologic, and clinical literature on the treatment of women with schizophrenia after menopause. Expert opinion: Beyond a relatively low dose threshold, all antipsychotic medications have adverse effects, which become more prominent for women at the time of menopause. Estrogen modulators may not help all symptoms of schizophrenia but are, nevertheless, relatively safe and, when used as adjuncts, help to keep antipsychotic doses low, thus reducing the side effect burden. The field is currently moving towards precision medicine and individual genetic profiles will help to determine the efficacy of available treatments in the future.

Coherent state coding approaches the capacity of non-Gaussian bosonic channels

NASA Astrophysics Data System (ADS)

Huber, Stefan; König, Robert

2018-05-01

The additivity problem asks if the use of entanglement can boost the information-carrying capacity of a given channel beyond what is achievable by coding with simple product states only. This has recently been shown not to be the case for phase-insensitive one-mode Gaussian channels, but remains unresolved in general. Here we consider two general classes of bosonic noise channels, which include phase-insensitive Gaussian channels as special cases: these are attenuators with general, potentially non-Gaussian environment states and classical noise channels with general probabilistic noise. We show that additivity violations, if existent, are rather minor for all these channels: the maximal gain in classical capacity is bounded by a constant independent of the input energy. Our proof shows that coding by simple classical modulation of coherent states is close to optimal.

Complex Virus-Host Interactions Involved in the Regulation of Classical Swine Fever Virus Replication: A Minireview.

PubMed

Li, Su; Wang, Jinghan; Yang, Qian; Naveed Anwar, Muhammad; Yu, Shaoxiong; Qiu, Hua-Ji

2017-07-05

Classical swine fever (CSF), caused by classical swine fever virus (CSFV), is one of the most devastating epizootic diseases of pigs in many countries. Viruses are small intracellular parasites and thus rely on the cellular factors for replication. Fundamental aspects of CSFV-host interactions have been well described, such as factors contributing to viral attachment, modulation of genomic replication and translation, antagonism of innate immunity, and inhibition of cell apoptosis. However, those host factors that participate in the viral entry, assembly, and release largely remain to be elucidated. In this review, we summarize recent progress in the virus-host interactions involved in the life cycle of CSFV and analyze the potential mechanisms of viral entry, assembly, and release. We conclude with future perspectives and highlight areas that require further understanding.

Complex Virus–Host Interactions Involved in the Regulation of Classical Swine Fever Virus Replication: A Minireview

PubMed Central

Li, Su; Wang, Jinghan; Yang, Qian; Naveed Anwar, Muhammad; Yu, Shaoxiong; Qiu, Hua-Ji

2017-01-01

Classical swine fever (CSF), caused by classical swine fever virus (CSFV), is one of the most devastating epizootic diseases of pigs in many countries. Viruses are small intracellular parasites and thus rely on the cellular factors for replication. Fundamental aspects of CSFV–host interactions have been well described, such as factors contributing to viral attachment, modulation of genomic replication and translation, antagonism of innate immunity, and inhibition of cell apoptosis. However, those host factors that participate in the viral entry, assembly, and release largely remain to be elucidated. In this review, we summarize recent progress in the virus–host interactions involved in the life cycle of CSFV and analyze the potential mechanisms of viral entry, assembly, and release. We conclude with future perspectives and highlight areas that require further understanding. PMID:28678154

Report on the Implementation of Homogeneous Nucleation Scheme in MARMOT-based Phase Field Simulation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Li, Yulan; Hu, Shenyang Y.; Sun, Xin

2013-09-30

In this report, we summarized our effort in developing mesoscale phase field models for predicting precipitation kinetics in alloys during thermal aging and/or under irradiation in nuclear reactors. The first part focused on developing a method to predict the thermodynamic properties of critical nuclei such as the sizes and concentration profiles of critical nuclei, and nucleation barrier. These properties are crucial for quantitative simulations of precipitate evolution kinetics with phase field models. Fe-Cr alloy was chosen as a model alloy because it has valid thermodynamic and kinetic data as well as it is an important structural material in nuclear reactors.more » A constrained shrinking dimer dynamics (CSDD) method was developed to search for the energy minimum path during nucleation. With the method we are able to predict the concentration profiles of the critical nuclei of Cr-rich precipitates and nucleation energy barriers. Simulations showed that Cr concentration distribution in the critical nucleus strongly depends on the overall Cr concentration as well as temperature. The Cr concentration inside the critical nucleus is much smaller than the equilibrium concentration calculated by the equilibrium phase diagram. This implies that a non-classical nucleation theory should be used to deal with the nucleation of Cr precipitates in Fe-Cr alloys. The growth kinetics of both classical and non-classical nuclei was investigated by the phase field approach. A number of interesting phenomena were observed from the simulations: 1) a critical classical nucleus first shrinks toward its non-classical nucleus and then grows; 2) a non-classical nucleus has much slower growth kinetics at its earlier growth stage compared to the diffusion-controlled growth kinetics. 3) a critical classical nucleus grows faster at the earlier growth stage than the non-classical nucleus. All of these results demonstrated that it is critical to introduce the correct critical nuclei into phase field modeling in order to correctly capture the kinetics of precipitation. In most alloys the matrix phase and precipitate phase have different concentrations as well as different crystal structures. For example, Cu precipitates in FeCu alloys have fcc crystal structure while the matrix Fe-Cu solid solution has bcc structure at low temperature. The WBM model and KimS model, where both concentrations and order parameters are chosen to describe the microstructures, are commonly used to model precipitations in such alloys. The WBM and KimS models have not been implemented into Marmot yet. In the second part of this report, we focused on implementing the WBM and KimS models into Marmot. The Fe-Cu alloys, which are important structure materials in nuclear reactors, was taken as the model alloys to test the models.« less

Anatomical Evidence for Classical and Extra-classical Receptive Field Completion Across the Discontinuous Horizontal Meridian Representation of Primate Area V2

PubMed Central

Jeffs, Janelle; Ichida, Jennifer M.; Federer, Frederick

2009-01-01

In primates, a split of the horizontal meridian (HM) representation at the V2 rostral border divides this area into dorsal (V2d) and ventral (V2v) halves (representing lower and upper visual quadrants, respectively), causing retinotopically neighboring loci across the HM to be distant within V2. How is perceptual continuity maintained across this discontinuous HM representation? Injections of neuroanatomical tracers in marmoset V2d demonstrated that cells near the V2d rostral border can maintain retinotopic continuity within their classical and extra-classical receptive field (RF), by making both local and long-range intra- and interareal connections with ventral cortex representing the upper visual quadrant. V2d neurons located <0.9–1.3 mm from the V2d rostral border, whose RFs presumably do not cross the HM, make nonretinotopic horizontal connections with V2v neurons in the supra- and infragranular layers. V2d neurons located <0.6–0.9 mm from the border, whose RFs presumably cross the HM, in addition make retinotopic local connections with V2v neurons in layer 4. V2d neurons also make interareal connections with upper visual field regions of extrastriate cortex, but not of MT or MTc outside the foveal representation. Labeled connections in ventral cortex appear to represent the “missing” portion of the connectional fields in V2d across the HM. We conclude that connections between dorsal and ventral cortex can create visual field continuity within a second-order discontinuous visual topography. PMID:18755777

Separation of variables in anisotropic models: anisotropic Rabi and elliptic Gaudin model in an external magnetic field

NASA Astrophysics Data System (ADS)

Skrypnyk, T.

2017-08-01

We study the problem of separation of variables for classical integrable Hamiltonian systems governed by non-skew-symmetric non-dynamical so(3)\\otimes so(3) -valued elliptic r-matrices with spectral parameters. We consider several examples of such models, and perform separation of variables for classical anisotropic one- and two-spin Gaudin-type models in an external magnetic field, and for Jaynes-Cummings-Dicke-type models without the rotating wave approximation.

Quantum image median filtering in the spatial domain

NASA Astrophysics Data System (ADS)

Li, Panchi; Liu, Xiande; Xiao, Hong

2018-03-01

Spatial filtering is one principal tool used in image processing for a broad spectrum of applications. Median filtering has become a prominent representation of spatial filtering because its performance in noise reduction is excellent. Although filtering of quantum images in the frequency domain has been described in the literature, and there is a one-to-one correspondence between linear spatial filters and filters in the frequency domain, median filtering is a nonlinear process that cannot be achieved in the frequency domain. We therefore investigated the spatial filtering of quantum image, focusing on the design method of the quantum median filter and applications in image de-noising. To this end, first, we presented the quantum circuits for three basic modules (i.e., Cycle Shift, Comparator, and Swap), and then, we design two composite modules (i.e., Sort and Median Calculation). We next constructed a complete quantum circuit that implements the median filtering task and present the results of several simulation experiments on some grayscale images with different noise patterns. Although experimental results show that the proposed scheme has almost the same noise suppression capacity as its classical counterpart, the complexity analysis shows that the proposed scheme can reduce the computational complexity of the classical median filter from the exponential function of image size n to the second-order polynomial function of image size n, so that the classical method can be speeded up.

Distinct effects of loss of classical estrogen receptor signaling versus complete deletion of estrogen receptor alpha on bone

PubMed Central

Syed, Farhan A.; Fraser, Daniel G.; Monroe, David G.; Khosla, Sundeep

2011-01-01

Estrogen receptor (ER)α is a major regulator of bone metabolism which can modulate gene expression via a “classical” pathway involving direct DNA binding to estrogen-response elements (EREs) or via “non-classical” pathways involving protein-protein interactions. While the skeletal consequences of loss of ERE binding by ERα have been described, a significant unresolved question is how loss of ERE binding differs from complete loss of ERα. Thus, we compared the skeletal phenotype of wild-type (ERα+/+) and ERα knock out (ERα−/−) mice with that of mice in which the only ERα present had a knock-in mutation abolishing ERE binding (non-classical ERα knock-in [NERKI], ERα−/NERKI). All three groups were in the same genetic background (C57BL/6). As compared to both ERα+/+ and ERα−/− mice, ERα−/NERKI mice had significantly reduced cortical volumetric bone mineral density and thickness at the tibial diaphysis; this was accompanied by significant decreases in periosteal and endocortical mineral apposition rates. Colony forming unit (CFU)-fibroblast, CFU-alkaline phosphatase, and CFU-osteoblast numbers were all increased in ERα−/− compared to ERα+/+ mice, but reduced in ERα−/NERKI mice compared to the two other groups. Thus, using mice in identical genetic backgrounds, our data indicate that the presence of an ERα that cannot bind DNA but can function through protein-protein interactions may have more deleterious skeletal effects than complete loss of ERα. These findings suggest that shifting the balance of classical versus non-classical ERα signaling triggers pathways that impair bone formation. Further studies defining these pathways may lead to novel approaches to selectively modulate ER signaling for beneficial skeletal effects. PMID:21458604

Atom optics in the time domain

NASA Astrophysics Data System (ADS)

Arndt, M.; Szriftgiser, P.; Dalibard, J.; Steane, A. M.

1996-05-01

Atom-optics experiments are presented using a time-modulated evanescent light wave as an atomic mirror in the trampoline configuration, i.e., perpendicular to the direction of the atomic free fall. This modulated mirror is used to accelerate cesium atoms, to focus their trajectories, and to apply a ``multiple lens'' to separately focus different velocity classes of atoms originating from a point source. We form images of a simple two-slit object to show the resolution of the device. The experiments are modelled by a general treatment analogous to classical ray optics.

Spherical type integrable classical systems in a magnetic field

NASA Astrophysics Data System (ADS)

Marchesiello, A.; Šnobl, L.; Winternitz, P.

2018-04-01

We show that four classes of second order spherical type integrable classical systems in a magnetic field exist in the Euclidean space {E}3 , and construct the Hamiltonian and two second order integrals of motion in involution for each of them. For one of the classes the Hamiltonian depends on four arbitrary functions of one variable. This class contains the magnetic monopole as a special case. Two further classes have Hamiltonians depending on one arbitrary function of one variable and four or six constants, respectively. The magnetic field in these cases is radial. The remaining system corresponds to a constant magnetic field and the Hamiltonian depends on two constants. Questions of superintegrability—i.e. the existence of further integrals—are discussed.

Preparation of two-qubit steady entanglement through driving a single qubit.

PubMed

Shen, Li-Tuo; Chen, Rong-Xin; Yang, Zhen-Biao; Wu, Huai-Zhi; Zheng, Shi-Biao

2014-10-15

Inspired by a recent paper [J. Phys. B 47, 055502 (2014)], we propose a simplified scheme to generate and stabilize a Bell state of two qubits coupled to a resonator. In the scheme only one qubit is needed to be driven by external classical fields, and the entanglement dynamics is independent of the phases of these fields and insensitive to their amplitude fluctuations. This is a distinct advantage as compared with the previous ones that require each qubit to be addressed by well-controlled classical fields. Numerical simulation shows that the steady singlet state with high fidelity can be obtained with currently available techniques in circuit quantum electrodynamics.

Multisymplectic Lagrangian and Hamiltonian Formalisms of Classical Field Theories

NASA Astrophysics Data System (ADS)

Román-Roy, Narciso

2009-11-01

This review paper is devoted to presenting the standard multisymplectic formulation for describing geometrically classical field theories, both the regular and singular cases. First, the main features of the Lagrangian formalism are revisited and, second, the Hamiltonian formalism is constructed using Hamiltonian sections. In both cases, the variational principles leading to the Euler-Lagrange and the Hamilton-De Donder-Weyl equations, respectively, are stated, and these field equations are given in different but equivalent geometrical ways in each formalism. Finally, both are unified in a new formulation (which has been developed in the last years), following the original ideas of Rusk and Skinner for mechanical systems.

Field failure mechanisms for photovoltaic modules

NASA Technical Reports Server (NTRS)

Dumas, L. N.; Shumka, A.

1981-01-01

Beginning in 1976, Department of Energy field centers have installed and monitored a number of field tests and application experiments using current state-of-the-art photovoltaic modules. On-site observations of module physical and electrical degradation, together with in-depth laboratory analysis of failed modules, permits an overall assessment of the nature and causes of early field failures. Data on failure rates are presented, and key failure mechanisms are analyzed with respect to origin, effect, and prospects for correction. It is concluded that all failure modes identified to date are avoidable or controllable through sound design and production practices.

Umbral Calculus and Holonomic Modules in Positive Characteristic

NASA Astrophysics Data System (ADS)

Kochubei, Anatoly N.

2006-03-01

In the framework of analysis over local fields of positive characteristic, we develop algebraic tools for introducing and investigating various polynomial systems. In this survey paper we describe a function field version of umbral calculus developed on the basis of a relation of binomial type satisfied by the Carlitz polynomials. We consider modules over the Weyl-Carlitz ring, a function field counterpart of the Weyl algebra. It is shown that some basic objects of function field arithmetic, like the Carlitz module, Thakur's hypergeometric polynomials, and analogs of binomial coefficients arising in the positive characteristic version of umbral calculus, generate holonomic modules.

Reexamination of Induction Heating of Primitive Bodies in Protoplanetary Disks

NASA Astrophysics Data System (ADS)

Menzel, Raymond L.; Roberge, Wayne G.

2013-10-01

We reexamine the unipolar induction mechanism for heating asteroids originally proposed in a classic series of papers by Sonett and collaborators. As originally conceived, induction heating is caused by the "motional electric field" that appears in the frame of an asteroid immersed in a fully ionized, magnetized solar wind and drives currents through its interior. However, we point out that classical induction heating contains a subtle conceptual error, in consequence of which the electric field inside the asteroid was calculated incorrectly. The problem is that the motional electric field used by Sonett et al. is the electric field in the freely streaming plasma far from the asteroid; in fact, the motional field vanishes at the asteroid surface for realistic assumptions about the plasma density. In this paper we revisit and improve the induction heating scenario by (1) correcting the conceptual error by self-consistently calculating the electric field in and around the boundary layer at the asteroid-plasma interface; (2) considering weakly ionized plasmas consistent with current ideas about protoplanetary disks; and (3) considering more realistic scenarios that do not require a fully ionized, powerful T Tauri wind in the disk midplane. We present exemplary solutions for two highly idealized flows that show that the interior electric field can either vanish or be comparable to the fields predicted by classical induction depending on the flow geometry. We term the heating driven by these flows "electrodynamic heating," calculate its upper limits, and compare them to heating produced by short-lived radionuclides.

Electronic structure and its external electric field modulation of PbPdO2 ultrathin slabs with (002) and (211) preferred orientations.

PubMed

Yang, Yanmin; Zhong, Kehua; Xu, Guigui; Zhang, Jian-Min; Huang, Zhigao

2017-07-31

The Electronic structure of PbPdO 2 with (002) and (211) preferred orientations were investigated using first-principles calculation. The calculated results indicate that, (002) and (211) orientations exhibit different electric field dependence of band-gap and carrier concentration. The small band gap and more sensitive electric field modulation of band gap were found in (002) orientation. Moreover, the electric field modulation of the resistivity up to 3-4 orders of magnitude is also observed in (002) slab, which reveals that origin of colossal electroresistance. Lastly, electric field modulation of band gap is well explained. This work should be significant for repeating the colossal electroresistance.

Modeling the Time-Course of Responses for the Border Ownership Selectivity Based on the Integration of Feedforward Signals and Visual Cortical Interactions

PubMed Central

Wagatsuma, Nobuhiko; Sakai, Ko

2017-01-01

Border ownership (BO) indicates which side of a contour owns a border, and it plays a fundamental role in figure-ground segregation. The majority of neurons in V2 and V4 areas of monkeys exhibit BO selectivity. A physiological work reported that the responses of BO-selective cells show a rapid transition when a presented square is flipped along its classical receptive field (CRF) so that the opposite BO is presented, whereas the transition is significantly slower when a square with a clear BO is replaced by an ambiguous edge, e.g., when the square is enlarged greatly. The rapid transition seemed to reflect the influence of feedforward processing on BO selectivity. Herein, we investigated the role of feedforward signals and cortical interactions for time-courses in BO-selective cells by modeling a visual cortical network comprising V1, V2, and posterior parietal (PP) modules. In our computational model, the recurrent pathways among these modules gradually established the visual progress and the BO assignments. Feedforward inputs mainly determined the activities of these modules. Surrounding suppression/facilitation of early-level areas modulates the activities of V2 cells to provide BO signals. Weak feedback signals from the PP module enhanced the contrast gain extracted in V1, which underlies the attentional modulation of BO signals. Model simulations exhibited time-courses depending on the BO ambiguity, which were caused by the integration delay of V1 and V2 cells and the local inhibition therein given the difference in input stimulus. However, our model did not fully explain the characteristics of crucially slow transition: the responses of BO-selective physiological cells indicated the persistent activation several times longer than that of our model after the replacement with the ambiguous edge. Furthermore, the time-course of BO-selective model cells replicated the attentional modulation of response time in human psychophysical experiments. These attentional modulations for time-courses were induced by selective enhancement of early-level features due to interactions between V1 and PP. Our proposed model suggests fundamental roles of surrounding suppression/facilitation based on feedforward inputs as well as the interactions between early and parietal visual areas with respect to the ambiguity dependence of the neural dynamics in intermediate-level vision. PMID:28163688

Modeling the Time-Course of Responses for the Border Ownership Selectivity Based on the Integration of Feedforward Signals and Visual Cortical Interactions.

PubMed

Wagatsuma, Nobuhiko; Sakai, Ko

2016-01-01

Border ownership (BO) indicates which side of a contour owns a border, and it plays a fundamental role in figure-ground segregation. The majority of neurons in V2 and V4 areas of monkeys exhibit BO selectivity. A physiological work reported that the responses of BO-selective cells show a rapid transition when a presented square is flipped along its classical receptive field (CRF) so that the opposite BO is presented, whereas the transition is significantly slower when a square with a clear BO is replaced by an ambiguous edge, e.g., when the square is enlarged greatly. The rapid transition seemed to reflect the influence of feedforward processing on BO selectivity. Herein, we investigated the role of feedforward signals and cortical interactions for time-courses in BO-selective cells by modeling a visual cortical network comprising V1, V2, and posterior parietal (PP) modules. In our computational model, the recurrent pathways among these modules gradually established the visual progress and the BO assignments. Feedforward inputs mainly determined the activities of these modules. Surrounding suppression/facilitation of early-level areas modulates the activities of V2 cells to provide BO signals. Weak feedback signals from the PP module enhanced the contrast gain extracted in V1, which underlies the attentional modulation of BO signals. Model simulations exhibited time-courses depending on the BO ambiguity, which were caused by the integration delay of V1 and V2 cells and the local inhibition therein given the difference in input stimulus. However, our model did not fully explain the characteristics of crucially slow transition: the responses of BO-selective physiological cells indicated the persistent activation several times longer than that of our model after the replacement with the ambiguous edge. Furthermore, the time-course of BO-selective model cells replicated the attentional modulation of response time in human psychophysical experiments. These attentional modulations for time-courses were induced by selective enhancement of early-level features due to interactions between V1 and PP. Our proposed model suggests fundamental roles of surrounding suppression/facilitation based on feedforward inputs as well as the interactions between early and parietal visual areas with respect to the ambiguity dependence of the neural dynamics in intermediate-level vision.

Acoustic field modulation in regenerators

NASA Astrophysics Data System (ADS)

Hu, J. Y.; Wang, W.; Luo, E. C.; Chen, Y. Y.

2016-12-01

The regenerator is a key component that transfers energy between heat and work. The conversion efficiency is significantly influenced by the acoustic field in the regenerator. Much effort has been spent to quantitatively determine this influence, but few comprehensive experimental verifications have been performed because of difficulties in modulating and measuring the acoustic field. In this paper, a method requiring two compressors is introduced and theoretically investigated that achieves acoustic field modulation in the regenerator. One compressor outputs the acoustic power for the regenerator; the other acts as a phase shifter. A RC load dissipates the acoustic power out of both the regenerator and the latter compressor. The acoustic field can be modulated by adjusting the current in the two compressors and opening the RC load. The acoustic field is measured with pressure sensors instead of flow-field imaging equipment, thereby greatly simplifying the experiment.

Differences in Visual-Spatial Input May Underlie Different Compression Properties of Firing Fields for Grid Cell Modules in Medial Entorhinal Cortex

PubMed Central

Raudies, Florian; Hasselmo, Michael E.

2015-01-01

Firing fields of grid cells in medial entorhinal cortex show compression or expansion after manipulations of the location of environmental barriers. This compression or expansion could be selective for individual grid cell modules with particular properties of spatial scaling. We present a model for differences in the response of modules to barrier location that arise from different mechanisms for the influence of visual features on the computation of location that drives grid cell firing patterns. These differences could arise from differences in the position of visual features within the visual field. When location was computed from the movement of visual features on the ground plane (optic flow) in the ventral visual field, this resulted in grid cell spatial firing that was not sensitive to barrier location in modules modeled with small spacing between grid cell firing fields. In contrast, when location was computed from static visual features on walls of barriers, i.e. in the more dorsal visual field, this resulted in grid cell spatial firing that compressed or expanded based on the barrier locations in modules modeled with large spacing between grid cell firing fields. This indicates that different grid cell modules might have differential properties for computing location based on visual cues, or the spatial radius of sensitivity to visual cues might differ between modules. PMID:26584432

Attentional Sensitization of Unconscious Cognition: Task Sets Modulate Subsequent Masked Semantic Priming

ERIC Educational Resources Information Center

Kiefer, Markus; Martens, Ulla

2010-01-01

According to classical theories, automatic processes are autonomous and independent of higher level cognitive influence. In contrast, the authors propose that automatic processing depends on attentional sensitization of task-congruent processing pathways. In 3 experiments, the authors tested this hypothesis with a modified masked semantic priming…

Cross-Channel Amplitude Sweeps Are Crucial to Speech Intelligibility

ERIC Educational Resources Information Center

Prendergast, Garreth; Green, Gary G. R.

2012-01-01

Classical views of speech perception argue that the static and dynamic characteristics of spectral energy peaks (formants) are the acoustic features that underpin phoneme recognition. Here we use representations where the amplitude modulations of sub-band filtered speech are described, precisely, in terms of co-sinusoidal pulses. These pulses are…

Voltage-Dependent Intrinsic Bursting in Olfactory Bulb Golgi Cells

ERIC Educational Resources Information Center

Pressler, R. Todd; Rozman, Peter A.; Strowbridge, Ben W.

2013-01-01

In the mammalian olfactory bulb (OB), local synaptic circuits modulate the evolving pattern of activity in mitral and tufted cells following olfactory sensory stimulation. GABAergic granule cells, the most numerous interneuron subtype in this brain region, have been extensively studied. However, classic studies using Golgi staining methods…

The Interaction of Concreteness and Phonological Similarity in Verbal Working Memory

ERIC Educational Resources Information Center

Acheson, Daniel J.; Postle, Bradley R.; MacDonald, Maryellen C.

2010-01-01

Although phonological representations have been a primary focus of verbal working memory research, lexical-semantic manipulations also influence performance. In the present study, the authors investigated whether a classic phenomenon in verbal working memory, the phonological similarity effect (PSE), is modulated by a lexical-semantic variable,…

Cerebellar Secretin Modulates Eyeblink Classical Conditioning

ERIC Educational Resources Information Center

Fuchs, Jason R.; Robinson, Gain M.; Dean, Aaron M.; Schoenberg, Heidi E.; Williams, Michael R.; Morielli, Anthony D.; Green, John T.

2014-01-01

We have previously shown that intracerebellar infusion of the neuropeptide secretin enhances the acquisition phase of eyeblink conditioning (EBC). Here, we sought to test whether endogenous secretin also regulates EBC and to test whether the effect of exogenous and endogenous secretin is specific to acquisition. In Experiment 1, rats received…

A ''Voice Inversion Effect?''

ERIC Educational Resources Information Center

Bedard, Catherine; Belin, Pascal

2004-01-01

Voice is the carrier of speech but is also an ''auditory face'' rich in information on the speaker's identity and affective state. Three experiments explored the possibility of a ''voice inversion effect,'' by analogy to the classical ''face inversion effect,'' which could support the hypothesis of a voice-specific module. Experiment 1 consisted…

A quantum analogy to the classical gravitomagnetic clock effect

NASA Astrophysics Data System (ADS)

Faruque, S. B.

2018-06-01

We present an approximation to the solution of Dirac equation in Schwarzschild field found through the use of Foldy-Wouthuysen Hamiltonian. We solve the equation for the positive energy states and found the frequencies by which the states oscillate. Difference of the periods of oscillation of the two states with two different total angular momentum quantum number j has an analogical form of the classical clock effect found in general relativity. But unlike the term that appears as clock effect in classical physics, here the term is quantized. Thus, we find a quantum analogue of the classical gravitomagnetic clock effect.

Bukhvostov-Lipatov model and quantum-classical duality

NASA Astrophysics Data System (ADS)

Bazhanov, Vladimir V.; Lukyanov, Sergei L.; Runov, Boris A.

2018-02-01

The Bukhvostov-Lipatov model is an exactly soluble model of two interacting Dirac fermions in 1 + 1 dimensions. The model describes weakly interacting instantons and anti-instantons in the O (3) non-linear sigma model. In our previous work [arxiv:arXiv:1607.04839] we have proposed an exact formula for the vacuum energy of the Bukhvostov-Lipatov model in terms of special solutions of the classical sinh-Gordon equation, which can be viewed as an example of a remarkable duality between integrable quantum field theories and integrable classical field theories in two dimensions. Here we present a complete derivation of this duality based on the classical inverse scattering transform method, traditional Bethe ansatz techniques and analytic theory of ordinary differential equations. In particular, we show that the Bethe ansatz equations defining the vacuum state of the quantum theory also define connection coefficients of an auxiliary linear problem for the classical sinh-Gordon equation. Moreover, we also present details of the derivation of the non-linear integral equations determining the vacuum energy and other spectral characteristics of the model in the case when the vacuum state is filled by 2-string solutions of the Bethe ansatz equations.

Universal scaling for the quantum Ising chain with a classical impurity

NASA Astrophysics Data System (ADS)

Apollaro, Tony J. G.; Francica, Gianluca; Giuliano, Domenico; Falcone, Giovanni; Palma, G. Massimo; Plastina, Francesco

2017-10-01

We study finite-size scaling for the magnetic observables of an impurity residing at the end point of an open quantum Ising chain with transverse magnetic field, realized by locally rescaling the field by a factor μ ≠1 . In the homogeneous chain limit at μ =1 , we find the expected finite-size scaling for the longitudinal impurity magnetization, with no specific scaling for the transverse magnetization. At variance, in the classical impurity limit μ =0 , we recover finite scaling for the longitudinal magnetization, while the transverse one basically does not scale. We provide both analytic approximate expressions for the magnetization and the susceptibility as well as numerical evidences for the scaling behavior. At intermediate values of μ , finite-size scaling is violated, and we provide a possible explanation of this result in terms of the appearance of a second, impurity-related length scale. Finally, by going along the standard quantum-to-classical mapping between statistical models, we derive the classical counterpart of the quantum Ising chain with an end-point impurity as a classical Ising model on a square lattice wrapped on a half-infinite cylinder, with the links along the first circle modified as a function of μ .

Superconductor to weak-insulator transitions in disordered tantalum nitride films

DOE PAGES

Breznay, Nicholas P.; Tendulkar, Mihir; Zhang, Li; ...

2017-10-31

Here, we study the two-dimensional superconductor-insulator transition (SIT) in thin films of tantalum nitride. At zero magnetic field, films can be disorder-tuned across the SIT by adjusting thickness and film stoichiometry; insulating films exhibit classical hopping transport. Superconducting films exhibit a magnetic-field-tuned SIT, whose insulating ground state at high field appears to be a quantum-corrected metal. Scaling behavior at the field-tuned SIT shows classical percolation critical exponents zν ≈ 1.3, with a corresponding critical field H c << H c2, the upper critical field. The Hall effect exhibits a crossing point near H c, but with a nonuniversal critical valuemore » ρ c xy comparable to the normal-state Hall resistivity. We propose that high-carrier-density metals will always exhibit this pattern of behavior at the boundary between superconducting and (trivially) insulating ground states.« less

2D materials in electro-optic modulation: energy efficiency, electrostatics, mode overlap, material transfer and integration

NASA Astrophysics Data System (ADS)

Ma, Zhizhen; Hemnani, Rohit; Bartels, Ludwig; Agarwal, Ritesh; Sorger, Volker J.

2018-02-01

Here we discuss the physics of electro-optic modulators deploying 2D materials. We include a scaling laws analysis and show how energy-efficiency and speed change for three underlying cavity systems as a function of critical device length scaling. A key result is that the energy-per-bit of the modulator is proportional to the volume of the device, thus making the case for submicron-scale modulators possible deploying a plasmonic optical mode. We then show how Graphene's Pauli-blocking modulation mechanism is sensitive to the device operation temperature, whereby a reduction of the temperature enables a 10× reduction in modulator energy efficiency. Furthermore, we show how the high-index tunability of graphene is able to compensate for the small optical overlap factor of 2D-based material modulators, which is unlike classical silicon-based dispersion devices. Lastly, we demonstrate a novel method towards a 2D material printer suitable for cross-contamination free and on-demand printing. The latter paves the way to integrate 2D materials seamlessly into taped-out photonic chips.

Scalar gravitational waves in the effective theory of gravity

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mottola, Emil

As a low energy effective field theory, classical General Relativity receives an infrared relevant modification from the conformal trace anomaly of the energy-momentum tensor of massless, or nearly massless, quantum fields. The local form of the effective action associated with the trace anomaly is expressed in terms of a dynamical scalar field that couples to the conformal factor of the spacetime metric, allowing it to propagate over macroscopic distances. Linearized around flat spacetime, this semi-classical EFT admits scalar gravitational wave solutions in addition to the transversely polarized tensor waves of the classical Einstein theory. The amplitude of the scalar wavemore » modes, as well as their energy and energy flux which are positive and contain a monopole moment, are computed. As a result, astrophysical sources for scalar gravitational waves are considered, with the excited gluonic condensates in the interiors of neutron stars in merger events with other compact objects likely to provide the strongest burst signals.« less

Scalar field quantum cosmology: A Schrödinger picture

NASA Astrophysics Data System (ADS)

Vakili, Babak

2012-11-01

We study the classical and quantum models of a scalar field Friedmann-Robertson-Walker (FRW) cosmology with an eye to the issue of time problem in quantum cosmology. We introduce a canonical transformation on the scalar field sector of the action such that the momentum conjugate to the new canonical variable appears linearly in the transformed Hamiltonian. Using this canonical transformation, we show that, it may lead to the identification of a time parameter for the corresponding dynamical system. In the cases of flat, closed and open FRW universes the classical cosmological solutions are obtained in terms of the introduced time parameter. Moreover, this formalism gives rise to a Schrödinger-Wheeler-DeWitt equation for the quantum-mechanical description of the model under consideration, the eigenfunctions of which can be used to construct the wave function of the universe. We use the resulting wave functions in order to investigate the possible corrections to the classical cosmologies due to quantum effects by means of the many-worlds and ontological interpretation of quantum cosmology.

Parametric resonance in tunable superconducting cavities

NASA Astrophysics Data System (ADS)

Wustmann, Waltraut; Shumeiko, Vitaly

2013-05-01

We develop a theory of parametric resonance in tunable superconducting cavities. The nonlinearity introduced by the superconducting quantum interference device (SQUID) attached to the cavity and damping due to connection of the cavity to a transmission line are taken into consideration. We study in detail the nonlinear classical dynamics of the cavity field below and above the parametric threshold for the degenerate parametric resonance, featuring regimes of multistability and parametric radiation. We investigate the phase-sensitive amplification of external signals on resonance, as well as amplification of detuned signals, and relate the amplifier performance to that of linear parametric amplifiers. We also discuss applications of the device for dispersive qubit readout. Beyond the classical response of the cavity, we investigate small quantum fluctuations around the amplified classical signals. We evaluate the noise power spectrum both for the internal field in the cavity and the output field. Other quantum-statistical properties of the noise are addressed such as squeezing spectra, second-order coherence, and two-mode entanglement.

Scalar gravitational waves in the effective theory of gravity

DOE PAGES

Mottola, Emil

2017-07-10

As a low energy effective field theory, classical General Relativity receives an infrared relevant modification from the conformal trace anomaly of the energy-momentum tensor of massless, or nearly massless, quantum fields. The local form of the effective action associated with the trace anomaly is expressed in terms of a dynamical scalar field that couples to the conformal factor of the spacetime metric, allowing it to propagate over macroscopic distances. Linearized around flat spacetime, this semi-classical EFT admits scalar gravitational wave solutions in addition to the transversely polarized tensor waves of the classical Einstein theory. The amplitude of the scalar wavemore » modes, as well as their energy and energy flux which are positive and contain a monopole moment, are computed. As a result, astrophysical sources for scalar gravitational waves are considered, with the excited gluonic condensates in the interiors of neutron stars in merger events with other compact objects likely to provide the strongest burst signals.« less

Optical nonclassicality test based on third-order intensity correlations

NASA Astrophysics Data System (ADS)

Rigovacca, L.; Kolthammer, W. S.; Di Franco, C.; Kim, M. S.

2018-03-01

We develop a nonclassicality criterion for the interference of three delayed, but otherwise identical, light fields in a three-mode Bell interferometer. We do so by comparing the prediction of quantum mechanics with those of a classical framework in which independent sources emit electric fields with random phases. In particular, we evaluate third-order correlations among output intensities as a function of the delays, and show how the presence of a correlation revival for small delays cannot be explained by the classical model of light. The observation of a revival is thus a nonclassicality signature, which can be achieved only by sources with a photon-number statistics that is highly sub-Poissonian. Our analysis provides strong evidence for the nonclassicality of the experiment discussed by Menssen et al. [Phys. Rev. Lett. 118, 153603 (2017), 10.1103/PhysRevLett.118.153603], and shows how a collective "triad" phase affects the interference of any three or more light fields, irrespective of their quantum or classical character.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hadsell, M; Xing, L; Bush, K

We propose a new type of treatment that employs a modulated tangential photon field to provide superior coverage of complex superficial targets when compared to other commonly employed methods, and drastically reduce dose to the underlying sensitive structures often present in these cases. TMAT plans were formulated for a set of four representative cases: 1. Scalp sarcoma, 2. Posterior chest-wall sarcoma, 3. Pleural mesothelioma with intact lung, 4. Chest-wall with deep inframammary nodes. For these cases, asymmetric jaw placement, angular limitations, and central isocenter placements were used to force optimization solutions with beam lines tangential to the body surface. Whenmore » compared with unrestricted modulated arcs, the tangential arc scalp treatment reduced the max and mean doses delivered to the brain by 33Gy (from 55Gy to 22Gy) and 6Gy (from 14Gy to 8Gy), respectively. In the posterior chest wall case, the V10 for the ipsilateral lung was kept below 5% impressively while retaining the 45Gy target prescription coverage by over 97%. For the breast chest-wall case, the TMAT plan achieved reductions in high dose to the ipsilateral lung and heart by a factor of 2–3 when compared to classic, laterally opposed, tangents and reduced the V5 by 40% when compared to standard modulated arcs. TMAT has outperformed the conventional modalities of treatment for superficial lesions used in our clinic. We hope that with the advent of digitally controlled linear accelerators, we can uncover further benefits of this new technique and extend its applicability to a wider section of the patient population.« less

Recent Developments in the Formability of Aluminum Alloys

NASA Astrophysics Data System (ADS)

Banabic, Dorel; Cazacu, Oana; Paraianu, Liana; Jurco, Paul

2005-08-01

The paper presents a few recent contributions brought by the authors in the field of the formability of aluminum alloys. A new concept for calculating Forming Limit Diagrams (FLD) using the finite element method is presented. The article presents a new strategy for calculating both branches of an FLD, using a Hutchinson - Neale model implemented in a finite element code. The simulations have been performed with Abaqus/Standard. The constitutive model has been implemented using a UMAT subroutine. The plastic anisotropy of the sheet metal is described by the Cazacu-Barlat and the BBC2003 yield criteria. The theoretical predictions have been compared with the results given by the classical Hutchinson - Neale method and also with experimental data for different aluminum alloys. The comparison proves the capability of the finite element method to predict the strain localization. A computer program used for interactive calculation and graphical representation of different Yield Loci and Forming Limit Diagrams has also been developed. The program is based on a Hutchinson-Neale model. Different yield criteria (Hill 1948, Barlat-Lian and BBC 2003) are implemented in this model. The program consists in three modules: a graphical interface for input, a module for the identification and visualization of the yield surfaces, and a module for calculating and visualizing the forming limit curves. A useful facility offered by the program is the possibility to perform the sensitivity analysis both for the yield surface and the forming limit curves. The numerical results can be compared with experimental data, using the import/export facilities included in the program.

Recent Developments in the Formability of Aluminum Alloys

DOE Office of Scientific and Technical Information (OSTI.GOV)

Banabic, Dorel; Paraianu, Liana; Jurco, Paul

The paper presents a few recent contributions brought by the authors in the field of the formability of aluminum alloys. A new concept for calculating Forming Limit Diagrams (FLD) using the finite element method is presented. The article presents a new strategy for calculating both branches of an FLD, using a Hutchinson - Neale model implemented in a finite element code. The simulations have been performed with Abaqus/Standard. The constitutive model has been implemented using a UMAT subroutine. The plastic anisotropy of the sheet metal is described by the Cazacu-Barlat and the BBC2003 yield criteria. The theoretical predictions have beenmore » compared with the results given by the classical Hutchinson - Neale method and also with experimental data for different aluminum alloys. The comparison proves the capability of the finite element method to predict the strain localization. A computer program used for interactive calculation and graphical representation of different Yield Loci and Forming Limit Diagrams has also been developed. The program is based on a Hutchinson-Neale model. Different yield criteria (Hill 1948, Barlat-Lian and BBC 2003) are implemented in this model. The program consists in three modules: a graphical interface for input, a module for the identification and visualization of the yield surfaces, and a module for calculating and visualizing the forming limit curves. A useful facility offered by the program is the possibility to perform the sensitivity analysis both for the yield surface and the forming limit curves. The numerical results can be compared with experimental data, using the import/export facilities included in the program.« less

Large current modulation and tunneling magnetoresistance change by a side-gate electric field in a GaMnAs-based vertical spin metal-oxide-semiconductor field-effect transistor.

PubMed

Kanaki, Toshiki; Yamasaki, Hiroki; Koyama, Tomohiro; Chiba, Daichi; Ohya, Shinobu; Tanaka, Masaaki

2018-05-08

A vertical spin metal-oxide-semiconductor field-effect transistor (spin MOSFET) is a promising low-power device for the post scaling era. Here, using a ferromagnetic-semiconductor GaMnAs-based vertical spin MOSFET with a GaAs channel layer, we demonstrate a large drain-source current I DS modulation by a gate-source voltage V GS with a modulation ratio up to 130%, which is the largest value that has ever been reported for vertical spin field-effect transistors thus far. We find that the electric field effect on indirect tunneling via defect states in the GaAs channel layer is responsible for the large I DS modulation. This device shows a tunneling magnetoresistance (TMR) ratio up to ~7%, which is larger than that of the planar-type spin MOSFETs, indicating that I DS can be controlled by the magnetization configuration. Furthermore, we find that the TMR ratio can be modulated by V GS . This result mainly originates from the electric field modulation of the magnetic anisotropy of the GaMnAs ferromagnetic electrodes as well as the potential modulation of the nonmagnetic semiconductor GaAs channel layer. Our findings provide important progress towards high-performance vertical spin MOSFETs.

Examination of the Structural Response of the Orion European Service Module to Reverberant and Direct Field Acoustic Testing

NASA Technical Reports Server (NTRS)

McNelis, Mark E.; Hughes, William O.; Larko, Jeffrey M.; Bittinger, Samantha A.; Le-Plenier, Cyprien; Fogt, Vincent A.; Ngan, Ivan; Thirkettle, Anthony C.; Skinner, Mitch; Larkin, Paul

2017-01-01

The NASA Orion Multi-Purpose Crew Vehicle (MPCV), comprised of the Service Module, the Crew Module, and the Launch Abort System, is the next generation human spacecraft designed and built for deep space exploration. Orion will launch on NASAs new heavy-lift rocket, the Space Launch System. The European Space Agency (ESA) is responsible for providing the propulsion sub-assembly of the Service Module to NASA, called the European Service Module (ESM). The ESM is being designed and built by Airbus Safran Launchers for ESA. Traditionally, NASA has utilized reverberant acoustic testing for qualification of spaceflight hardware. The ESM Structural Test Article (E-STA) was tested at the NASA Plum Brook Stations (PBS) Reverberant Acoustic Test Facility in April-May 2016. However, Orion is evaluating an alternative acoustic test method, using direct field acoustic excitation, for the MPCVs Service Module and Crew Module. Lockheed Martin is responsible for the Orion proof-of-concept direct field acoustic test program. The E-STA was exposed to direct field acoustic testing at NASA PBS in February 2017. This paper compares the dynamic response of the E-STA structure and its components to both the reverberant and direct field acoustic test excitations. Advantages and disadvantages of direct field acoustic test excitation method are discussed.

Predictive of the quantum capacitance effect on the excitation of plasma waves in graphene transistors with scaling limit

NASA Astrophysics Data System (ADS)

Wang, Lin; Chen, Xiaoshuang; Hu, Yibin; Wang, Shao-Wei; Lu, Wei

2015-04-01

Plasma waves in graphene field-effect transistors (FETs) and nano-patterned graphene sheets have emerged as very promising candidates for potential terahertz and infrared applications in myriad areas including remote sensing, biomedical science, military, and many other fields with their electrical tunability and strong interaction with light. In this work, we study the excitations and propagation properties of plasma waves in nanometric graphene FETs down to the scaling limit. Due to the quantum-capacitance effect, the plasma wave exhibits strong correlation with the distribution of density of states (DOS). It is indicated that the electrically tunable plasma resonance has a power-dependent V0.8TG relation on the gate voltage, which originates from the linear dependence of density of states (DOS) on the energy in pristine graphene, in striking difference to those dominated by classical capacitance with only V0.5TG dependence. The results of different transistor sizes indicate the potential application of nanometric graphene FETs in highly-efficient electro-optic modulation or detection of terahertz or infrared radiation. In addition, we highlight the perspectives of plasma resonance excitation in probing the many-body interaction and quantum matter state in strong correlation electron systems. This study reveals the key feature of plasma waves in decorated/nanometric graphene FETs, and paves the way to tailor plasma band-engineering and expand its application in both terahertz and mid-infrared regions.Plasma waves in graphene field-effect transistors (FETs) and nano-patterned graphene sheets have emerged as very promising candidates for potential terahertz and infrared applications in myriad areas including remote sensing, biomedical science, military, and many other fields with their electrical tunability and strong interaction with light. In this work, we study the excitations and propagation properties of plasma waves in nanometric graphene FETs down to the scaling limit. Due to the quantum-capacitance effect, the plasma wave exhibits strong correlation with the distribution of density of states (DOS). It is indicated that the electrically tunable plasma resonance has a power-dependent V0.8TG relation on the gate voltage, which originates from the linear dependence of density of states (DOS) on the energy in pristine graphene, in striking difference to those dominated by classical capacitance with only V0.5TG dependence. The results of different transistor sizes indicate the potential application of nanometric graphene FETs in highly-efficient electro-optic modulation or detection of terahertz or infrared radiation. In addition, we highlight the perspectives of plasma resonance excitation in probing the many-body interaction and quantum matter state in strong correlation electron systems. This study reveals the key feature of plasma waves in decorated/nanometric graphene FETs, and paves the way to tailor plasma band-engineering and expand its application in both terahertz and mid-infrared regions. Electronic supplementary information (ESI) available. See DOI: 10.1039/c4nr07689c

A Classical Based Derivation of Time Dilation Providing First Order Accuracy to Schwarzschild's Solution of Einstein's Field Equations

NASA Astrophysics Data System (ADS)

Austin, Rickey W.

In Einstein's theory of Special Relativity (SR), one method to derive relativistic kinetic energy is via applying the classical work-energy theorem to relativistic momentum. This approach starts with a classical based work-energy theorem and applies SR's momentum to the derivation. One outcome of this derivation is relativistic kinetic energy. From this derivation, it is rather straight forward to form a kinetic energy based time dilation function. In the derivation of General Relativity a common approach is to bypass classical laws as a starting point. Instead a rigorous development of differential geometry and Riemannian space is constructed, from which classical based laws are derived. This is in contrast to SR's approach of starting with classical laws and applying the consequences of the universal speed of light by all observers. A possible method to derive time dilation due to Newtonian gravitational potential energy (NGPE) is to apply SR's approach to deriving relativistic kinetic energy. It will be shown this method gives a first order accuracy compared to Schwarzschild's metric. The SR's kinetic energy and the newly derived NGPE derivation are combined to form a Riemannian metric based on these two energies. A geodesic is derived and calculations compared to Schwarzschild's geodesic for an orbiting test mass about a central, non-rotating, non-charged massive body. The new metric results in high accuracy calculations when compared to Einsteins General Relativity's prediction. The new method provides a candidate approach for starting with classical laws and deriving General Relativity effects. This approach mimics SR's method of starting with classical mechanics when deriving relativistic equations. As a compliment to introducing General Relativity, it provides a plausible scaffolding method from classical physics when teaching introductory General Relativity. A straight forward path from classical laws to General Relativity will be derived. This derivation provides a minimum first order accuracy to Schwarzschild's solution to Einstein's field equations.

Radiation Therapy Planning for Early-Stage Hodgkin Lymphoma: Experience of the International Lymphoma Radiation Oncology Group

DOE Office of Scientific and Technical Information (OSTI.GOV)

Maraldo, Maja V., E-mail: dra.maraldo@gmail.com; Dabaja, Bouthaina S.; Filippi, Andrea R.

Purpose: Early-stage Hodgkin lymphoma (HL) is a rare disease, and the location of lymphoma varies considerably between patients. Here, we evaluate the variability of radiation therapy (RT) plans among 5 International Lymphoma Radiation Oncology Group (ILROG) centers with regard to beam arrangements, planning parameters, and estimated doses to the critical organs at risk (OARs). Methods: Ten patients with stage I-II classic HL with masses of different sizes and locations were selected. On the basis of the clinical information, 5 ILROG centers were asked to create RT plans to a prescribed dose of 30.6 Gy. A postchemotherapy computed tomography scan with precontouredmore » clinical target volume (CTV) and OARs was provided for each patient. The treatment technique and planning methods were chosen according to each center's best practice in 2013. Results: Seven patients had mediastinal disease, 2 had axillary disease, and 1 had disease in the neck only. The median age at diagnosis was 34 years (range, 21-74 years), and 5 patients were male. Of the resulting 50 treatment plans, 15 were planned with volumetric modulated arc therapy (1-4 arcs), 16 with intensity modulated RT (3-9 fields), and 19 with 3-dimensional conformal RT (2-4 fields). The variations in CTV-to-planning target volume margins (5-15 mm), maximum tolerated dose (31.4-40 Gy), and plan conformity (conformity index 0-3.6) were significant. However, estimated doses to OARs were comparable between centers for each patient. Conclusions: RT planning for HL is challenging because of the heterogeneity in size and location of disease and, additionally, to the variation in choice of treatment techniques and field arrangements. Adopting ILROG guidelines and implementing universal dose objectives could further standardize treatment techniques and contribute to lowering the dose to the surrounding OARs.« less

Higher spin gauge theory on fuzzy \\boldsymbol {S^4_N}

NASA Astrophysics Data System (ADS)

Sperling, Marcus; Steinacker, Harold C.

2018-02-01

We examine in detail the higher spin fields which arise on the basic fuzzy sphere S^4N in the semi-classical limit. The space of functions can be identified with functions on classical S 4 taking values in a higher spin algebra associated to \

Research on a new magnetic-field-modulated brushless double-rotor machine with sinusoidal-permeance modulating ring

NASA Astrophysics Data System (ADS)

Zheng, Ping; Liu, Jiaqi; Bai, Jingang; Song, Zhiyi; Liu, Yong

2017-05-01

The magnetic-field-modulated brushless double-rotor machine (MFM-BDRM), composed of a stator, a modulating ring rotor, and a PM rotor, is a kind of power-split device for hybrid electric vehicles (HEVs). In this paper, a new MFM-BDRM with sinusoidal-permeance modulating ring named Sinusoidal-Permeance-Modulating-Ring Brushless Double-Rotor Machine (SPMR-BDRM) is proposed to solve the problem of poor mechanical strength and large iron loss. The structure and the operating principle of the MFM-BDRM are introduced. The design principle of the sinusoidal-permeance modulating ring is analyzed and derived. The main idea of that is to minimize the harmonic permeance of air gap, thereby the harmonic magnetic fields can be restrained. There are comparisons between a MFM-BDRM with sinusoidal-permeance modulating ring and a same size MFM-BDRM with traditional modulating ring, including magnetic field distributions and electromagnetic performances. Most importantly, the iron losses are compared under six different conditions. The result indicates that the harmonic magnetic fields in the air gap are restrained; the electromagnetic torque and power factor are almost the same with same armature current; the torque ripples of the modulating ring rotor and the PM rotor are reduced; the stator loss is reduced by 13% at least and the PM loss is reduced by 20% at least compared with the same size traditional MFM-BDRM under the same operating conditions.

Quantum cosmology of a Bianchi III LRS geometry coupled to a source free electromagnetic field

NASA Astrophysics Data System (ADS)

Karagiorgos, A.; Pailas, T.; Dimakis, N.; Terzis, Petros A.; Christodoulakis, T.

2018-03-01

We consider a Bianchi type III axisymmetric geometry in the presence of an electromagnetic field. A first result at the classical level is that the symmetry of the geometry need not be applied on the electromagnetic tensor Fμν the algebraic restrictions, implied by the Einstein field equations to the stress energy tensor Tμν, suffice to reduce the general Fμν to the appropriate form. The classical solution thus found contains a time dependent electric and a constant magnetic charge. The solution is also reachable from the corresponding mini-superspace action, which is strikingly similar to the Reissner-Nordstr{öm one. This points to a connection between the black hole geometry and the cosmological solution here found, which is the analog of the known correlation between the Schwarzschild and the Kantowski-Sachs metrics. The configuration space is drastically modified by the presence of the magnetic charge from a 3D flat to a 3D pp wave geometry. We map the emerging linear and quadratic classical integrals of motion, to quantum observables. Along with the Wheeler-DeWitt equation these observables provide unique, up to constants, wave functions. The employment of a Bohmian interpretation of these quantum states results in deterministic (semi-classical) geometries most of which are singularity free.

JOURNAL SCOPE GUIDELINES: Paper classification scheme

NASA Astrophysics Data System (ADS)

2005-06-01

This scheme is used to clarify the journal's scope and enable authors and readers to more easily locate the appropriate section for their work. For each of the sections listed in the scope statement we suggest some more detailed subject areas which help define that subject area. These lists are by no means exhaustive and are intended only as a guide to the type of papers we envisage appearing in each section. We acknowledge that no classification scheme can be perfect and that there are some papers which might be placed in more than one section. We are happy to provide further advice on paper classification to authors upon request (please email jphysa@iop.org). 1. Statistical physics numerical and computational methods statistical mechanics, phase transitions and critical phenomena quantum condensed matter theory Bose-Einstein condensation strongly correlated electron systems exactly solvable models in statistical mechanics lattice models, random walks and combinatorics field-theoretical models in statistical mechanics disordered systems, spin glasses and neural networks nonequilibrium systems network theory 2. Chaotic and complex systems nonlinear dynamics and classical chaos fractals and multifractals quantum chaos classical and quantum transport cellular automata granular systems and self-organization pattern formation biophysical models 3. Mathematical physics combinatorics algebraic structures and number theory matrix theory classical and quantum groups, symmetry and representation theory Lie algebras, special functions and orthogonal polynomials ordinary and partial differential equations difference and functional equations integrable systems soliton theory functional analysis and operator theory inverse problems geometry, differential geometry and topology numerical approximation and analysis geometric integration computational methods 4. Quantum mechanics and quantum information theory coherent states eigenvalue problems supersymmetric quantum mechanics scattering theory relativistic quantum mechanics semiclassical approximations foundations of quantum mechanics and measurement theory entanglement and quantum nonlocality geometric phases and quantum tomography quantum tunnelling decoherence and open systems quantum cryptography, communication and computation theoretical quantum optics 5. Classical and quantum field theory quantum field theory gauge and conformal field theory quantum electrodynamics and quantum chromodynamics Casimir effect integrable field theory random matrix theory applications in field theory string theory and its developments classical field theory and electromagnetism metamaterials 6. Fluid and plasma theory turbulence fundamental plasma physics kinetic theory magnetohydrodynamics and multifluid descriptions strongly coupled plasmas one-component plasmas non-neutral plasmas astrophysical and dusty plasmas

From classical to quantum plasmonics: Classical emitter and SPASER

NASA Astrophysics Data System (ADS)

Balykin, V. I.

2018-02-01

The key advantage of plasmonics is in pushing our control of light down to the nanoscale. It is possible to envision lithographically fabricated plasmonic devices for future quantum information processing or cryptography at the nanoscale in two dimensions. A first step in this direction is a demonstration of a highly efficient nanoscale light source. Here we demonstrate two types of nanoscale sources of optical fields: 1) the classical metallic nanostructure emitter and 2) the plasmonic nanolaser - SPASER.

Emergence of a classical Universe from quantum gravity and cosmology.

PubMed

Kiefer, Claus

2012-09-28

I describe how we can understand the classical appearance of our world from a universal quantum theory. The essential ingredient is the process of decoherence. I start with a general discussion in ordinary quantum theory and then turn to quantum gravity and quantum cosmology. There is a whole hierarchy of classicality from the global gravitational field to the fluctuations in the cosmic microwave background, which serve as the seeds for the structure in the Universe.

The Evolution of NR TrA (Nova TrA 2008) from 2008 through 2017

NASA Astrophysics Data System (ADS)

Walter, Frederick M.; Burwitz, Vadim; Kafka, Stella

2018-06-01

The classical nova NR TrA was discovered as an O-type optically-thick classical nova. There is no evidence that it formed dust. Within four years the envelope became sufficiently thin to reveal an eclipsing accretion disk-dominated system with orbitally-modulated permitted lines of C IV, N V, and O VI. XMM observations reveal a non-eclipsing soft X-ray source and a deeply-eclipsing UV continuum. We will present the first ten years of optical spectral evolution of this system accompanied by ten years of BVRIJHK photometry, with an eye to deciphering the current nature of the system.

Citation classics in neuro-oncology: assessment of historical trends and scientific progress.

PubMed

Hachem, Laureen D; Mansouri, Alireza; Juraschka, Kyle; Taslimi, Shervin; Pirouzmand, Farhad; Zadeh, Gelareh

2017-09-01

Citation classics represent the highest cited works in a field and are often regarded as the most influential literature. Analyzing thematic trends in citation classics across eras enables recognition of important historical advances within a field. We present the first analysis of the citation classics in neuro-oncology. The Web of Science database was searched using terms relevant to "neuro-oncology." Articles with >400 citations were identified and the top 100 cited articles were evaluated. The top 100 neuro-oncology citation classics consisted of 43 clinical studies (17 retrospective, 10 prospective, 16 randomized trials), 43 laboratory investigations, 8 reviews/meta-analyses, and 6 guidelines/consensus statements. Articles were classified into 4 themes: 13 pertained to tumor classification, 37 to tumor pathogenesis/clinical presentation, 6 to imaging, 44 to therapy (15 chemotherapy, 10 radiotherapy, 5 surgery, 14 new agents). Gliomas were the most common tumor type examined, with 70 articles. There was a significant increase in the number of citation classics in the late 1990s, which was paralleled by an increase in studies examining tumor pathogenesis, chemotherapy, and new agents along with laboratory and randomized studies. The majority of citation classics in neuro-oncology are related to gliomas and pertain to tumor pathogenesis and treatment. The rise in citation classics in recent years investigating tumor biology, new treatment agents, and chemotherapeutics may reflect increasing scientific interest in nonsurgical treatments for CNS tumors and the need for fundamental investigations into disease processes. © The Author(s) 2017. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com

Steering Quantum States Towards Classical Bohr-Like Orbits

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dunning, F. B.; Reinhold, Carlos O; Yoshida, S.

2010-01-01

This article furnishes an introduction to the properties of time-dependent electronic wavefunctions in atoms and to physics at the interface between the quantum and classical worlds. We describe how, almost 100 years after the introduction of the Bohr model of the atom, it is now possible using pulsed electric fields to create in the laboratory localized wavepackets in high-n (n ~ 300) Rydberg atoms that travel in near-circular Bohr-like orbits mimicking the behavior of a classical electron. The control protocols employed are explained with the aid of quantum and classical dynamics. Remarkably, while many aspects of the underlying behavior canmore » be described using classical arguments, even at n ~ 300 purely quantum effects such as revivals can be seen.« less

Development of novel cardiovascular therapeutics from small regulatory RNA molecules--an outline of key requirements.

PubMed

Poller, W; Fechner, H

2010-01-01

Understanding of the roles of RNAs within the cell has changed and expanded dramatically during the past few years. Based on fundamentally new insights it is now increasingly possible to employ RNAs as highly valuable tools in molecular biology and medicine. At present, the most important therapeutic strategies are based on non-coding regulatory RNAs inducing RNA interference (RNAi) to silence single genes, and on modulation of cellular microRNAs (miRNAs) to alter complex gene expression patterns in diseased organs. Only recently it became possible to target therapeutic RNAi to specific organs via organotropic viral vector systems and we discuss the most recent strategies in this field, e.g. heart failure treatment by cardiac-targeted RNAi. Due to the peculiar biochemical properties of small RNA molecules, true therapeutic translation of results in vitro is more demanding than with small molecule drugs or proteins. Specifically, there is a critical requirement for extensive studies in animal models of human disease after pre-testing of the RNAi tools in vitro. This requirement likewise applies for miRNA modulations which have complex consequences in the recipient dependent on biochemical stability and distribution of the therapeutic RNA. Problems not yet fully solved are the prediction of targets and specificity of the RNA tools. However, major progress has been made to achieve their tissue-specific and regulatable expression, and breakthroughs in vector technologies from the gene therapy field have fundamentally improved safety and efficacy of RNA-based therapeutic approaches, too. In summary, insight into the molecular mechanisms of action of regulatory RNAs in combination with new delivery tools for RNA therapeutics will significantly expand our cardiovascular therapeutic repertoire beyond classical pharmacology.

Structural aspects of the solvation shell of lysine and acetylated lysine: A Car-Parrinello and classical molecular dynamics investigation

NASA Astrophysics Data System (ADS)

Carnevale, V.; Raugei, S.

2009-12-01

Lysine acetylation is a post-translational modification, which modulates the affinity of protein-protein and/or protein-DNA complexes. Its crucial role as a switch in signaling pathways highlights the relevance of charged chemical groups in determining the interactions between water and biomolecules. A great effort has been recently devoted to assess the reliability of classical molecular dynamics simulations in describing the solvation properties of charged moieties. In the spirit of these investigations, we performed classical and Car-Parrinello molecular dynamics simulations on lysine and acetylated-lysine in aqueous solution. A comparative analysis between the two computational schemes is presented with a focus on the first solvation shell of the charged groups. An accurate structural analysis unveils subtle, yet statistically significant, differences which are discussed in connection to the significant electronic density charge transfer occurring between the solute and the surrounding water molecules.

G protein-coupled receptor 30 in tumor development.

PubMed

Wang, Dengfeng; Hu, Lina; Zhang, Guonan; Zhang, Lin; Chen, Chen

2010-08-01

Estrogen plays several important physiological and pathological functions in not only reproductive system but many other systems as well. Its transcriptional activation has been traditionally described as being mediated by classic nuclear estrogen receptors (ERs). It is however established recently that a novel functional estrogen transmembrane receptor, G protein-coupled receptor 30 (GPR30), modulates both rapid non-genomic events and genomic transcriptional events of estrogen. It has been demonstrated that GPR30 promotes the progress of estrogen-related tumors through mitogen-activated protein kinase (MAPK) signaling pathways. Effects mediated by GPR30 are maintained when classic ERs are absent or blocked. In addition, GPR30 is involved in drug resistance, which is often occurring during cancer treatments. All these new findings strongly imply that GPR30 may be an important therapeutic target for estrogen-related tumors. Simultaneously blocking both GPR30 and classic ERs may be a better strategy for the treatment of estrogen-related tumors.

Perturbing laser field dependent high harmonic phase modulations

NASA Astrophysics Data System (ADS)

Li, Zhengyan; Kong, Fanqi; Brown, Graham; Hammond, TJ; Ko, Dong-Hyuk; Zhang, Chunmei; Corkum, P. B.

2018-06-01

A perturbing laser pulse modulates and controls the phase of the high harmonic radiation driven by an intense fundamental pulse. Thus, a structured wave front can impress a specific spatial phase onto the generated high harmonic wave front. This modulation procedure leads to all-optical spatial light modulators for VUV or XUV radiation created by high harmonic generation. Here, through theoretical analysis and experiment, we study the correlation between the high harmonic phase modulations and the perturbing laser field amplitude and phase, providing guidelines for practical high harmonic spatial light modulators. In addition, we show that the petahertz optical oscilloscope for measuring electric fields of a perturbing beam is most robust using low order harmonics, far from the cut-off.

Effect of exposure time on mass-rearing production of the olive fruit fly parasitoid, Psyttalia lounsburyi (Hymenoptera: Braconidae)

USDA-ARS?s Scientific Manuscript database

Classical biological control programs rely on mass-production of high quality beneficial insects for subsequent releases into the field. Psyttalia lounsburyi (Silvestri) (Hymenoptera: Braconidae) is a koinobiont larval-pupal endoparasitoid of tephritid flies that is being reared to support a classic...

Data from: Retrospective analysis of a classical biological control programme

USDA-ARS?s Scientific Manuscript database

This database contains the raw data for the publication entitled Naranjo, S.E. 2018. Retrospective analysis of a classical biological control programme. Journal of Applied Ecology https://doi.org/10.1111/1365-2664.13163. Specific data include field-based, partial life table data for immature stage...

Rationale for classical biological control of cattle fever ticks and proposed methods for field collection of natural enemies

USDA-ARS?s Scientific Manuscript database

Classical biological control using specialist parasitoids, predators and/or nematodes from the native ranges of cattle fever ticks Rhipicephalus microplus and Rhipicephalus annulatus could complement existing control strategies for this livestock pest in the transboundary region between Mexico and T...

Sociology Dismissing Religion? The Presentation of Religious Change in Introductory Sociology Textbooks

ERIC Educational Resources Information Center

Featherstone, Richard; Sorrell, Katie L.

2007-01-01

This paper explores whether the field of sociology harbors a dismissive attitude towards religion. Specifically it examines whether introductory sociology textbooks present the classic secularization theory over the more recent religious economies explanation of religious change. The classical secularization thesis suggests that religion is…

Continuous-variable quantum network coding for coherent states

NASA Astrophysics Data System (ADS)

Shang, Tao; Li, Ke; Liu, Jian-wei

2017-04-01

As far as the spectral characteristic of quantum information is concerned, the existing quantum network coding schemes can be looked on as the discrete-variable quantum network coding schemes. Considering the practical advantage of continuous variables, in this paper, we explore two feasible continuous-variable quantum network coding (CVQNC) schemes. Basic operations and CVQNC schemes are both provided. The first scheme is based on Gaussian cloning and ADD/SUB operators and can transmit two coherent states across with a fidelity of 1/2, while the second scheme utilizes continuous-variable quantum teleportation and can transmit two coherent states perfectly. By encoding classical information on quantum states, quantum network coding schemes can be utilized to transmit classical information. Scheme analysis shows that compared with the discrete-variable paradigms, the proposed CVQNC schemes provide better network throughput from the viewpoint of classical information transmission. By modulating the amplitude and phase quadratures of coherent states with classical characters, the first scheme and the second scheme can transmit 4{log _2}N and 2{log _2}N bits of information by a single network use, respectively.

On the Construction and Dynamics of Knotted Fields

NASA Astrophysics Data System (ADS)

Kedia, Hridesh

Representing a physical field in terms of its field lines has often enabled a deeper understanding of complex physical phenomena, from Faraday's law of magnetic induction, to the Helmholtz laws of vortex motion, to the free energy density of liquid crystals in terms of the distortions of the lines of the director field. At the same time, the application of ideas from topology--the study of properties that are invariant under continuous deformations--has led to robust insights into the nature of complex physical systems from defects in crystal structures, to the earth's magnetic field, to topological conservation laws. The study of knotted fields, physical fields in which the field lines encode knots, emerges naturally from the application of topological ideas to the investigation of the physical phenomena best understood in terms of the lines of a field. A knot--a closed loop tangled with itself which can not be untangled without cutting the loop--is the simplest topologically non-trivial object constructed from a line. Remarkably, knots in the vortex (magnetic field) lines of a dissipationless fluid (plasma), persist forever as they are transported by the flow, stretching and rotating as they evolve. Moreover, deeply entwined with the topology-preserving dynamics of dissipationless fluids and plasmas, is an additional conserved quantity--helicity, a measure of the average linking of the vortex (magnetic field) lines in a fluid (plasma)--which has had far-reaching consequences for fluids and plasmas. Inspired by the persistence of knots in dissipationless flows, and their far-reaching physical consequences, we seek to understand the interplay between the dynamics of a field and the topology of its field lines in a variety of systems. While it is easy to tie a knot in a shoelace, tying a knot in the the lines of a space-filling field requires contorting the lines everywhere to match the knotted region. The challenge of analytically constructing knotted field configurations has impeded a deeper understanding of the interplay between topology and dynamics in fluids and plasmas. We begin by analytically constructing knotted field configurations which encode a desired knot in the lines of the field, and show that their helicity can be tuned independently of the encoded knot. The nonlinear nature of the physical systems in which these knotted field configurations arise, makes their analytical study challenging. We ask if a linear theory such as electromagnetism can allow knotted field configurations to persist with time. We find analytical expressions for an infinite family of knotted solutions to Maxwell's equations in vacuum and elucidate their connections to dissipationless flows. We present a design rule for constructing such persistently knotted electromagnetic fields, which could possibly be used to transfer knottedness to matter such as quantum fluids and plasmas. An important consequence of the persistence of knots in classical dissipationless flows is the existence of an additional conserved quantity, helicity, which has had far-reaching implications. To understand the existence of analogous conserved quantities, we ask if superfluids, which flow without dissipation just like classical dissipationless flows, have an additional conserved quantity akin to helicity. We address this question using an analytical approach based on defining the particle relabeling symmetry--the symmetry underlying helicity conservation--in superfluids, and find that an analogous conserved quantity exists but vanishes identically owing to the intrinsic geometry of complex scalar fields. Furthermore, to address the question of a ``classical limit'' of superfluid vortices which recovers classical helicity conservation, we perform numerical simulations of \\emph{bundles} of superfluid vortices, and find behavior akin to classical viscous flows.

Roto-chemical heating in a neutron star with fall-back disc accretion

NASA Astrophysics Data System (ADS)

Wei, Wei; Liu, Xi-Wei; Zheng, Xiao-Ping

2018-07-01

Recent research on the classical pulsar B0950+08 demonstrates that the explanation of its high surface temperature by roto-chemical heating encounters some difficulties. We assume that there is a fall-back disc around the newborn neutron star, which originates from the supernova ejecta and influences the spin and magnetic evolution of the star. By taking into account disc accretion and magnetic field evolution simultaneously, the effect of the fall-back disc accretion process on the roto-chemical heating in the neutron star is studied. The results show that there are two roto-chemical deviation phases (spin-up deviation and spin-down deviation), but that only the spin-down deviation leads to heating. The specific cooling curve depends on the accretion disc mass, the initial magnetic field and the magnetic field decay rate. Most importantly, the observations of surface temperature, magnetic field strength and spin period of the classical pulsar B0950+08 are well explained by the accretion roto-chemical heating model. The fall-back accretion process is important in roto-chemical heating for explanations of classical pulsars with high temperature. Given the absence of any evidence of fall-back accretion on to B0950+08, our study is purely hypothetical.

Electrically-controlled near-field radiative thermal modulator made of graphene-coated silicon carbide plates

NASA Astrophysics Data System (ADS)

Yang, Yue; Wang, Liping

2017-08-01

In this work, we propose a hybrid near-field radiative thermal modulator made of two graphene-covered silicon carbide (SiC) plates separated by a nanometer vacuum gap. The near-field photon tunneling between the emitter and receiver is modulated by changing graphene chemical potentials with symmetrically or asymmetrically applied voltage biases. The radiative heat flux calculated from fluctuational electrodynamics significantly varies with graphene chemical potentials due to tunable near-field coupling strength between graphene plasmons across the vacuum gap. Thermal modulation and switching, which are the key functionalities required for a thermal modulator, are theoretically realized and analyzed. Newly introduced quantities of the modulation factor, the sensitivity factor and switching factor are studied quite extensively in a large parameter range for both graphene chemical potential and vacuum gap distance. This opto-electronic device with faster operating mode, which is in principle only limited by electronics and not by the thermal inertia, will facilitate the practical application of active thermal management, thermal circuits, and thermal computing with photon-based near-field thermal transport.

Neural control of visual search by frontal eye field: effects of unexpected target displacement on visual selection and saccade preparation.

PubMed

Murthy, Aditya; Ray, Supriya; Shorter, Stephanie M; Schall, Jeffrey D; Thompson, Kirk G

2009-05-01

The dynamics of visual selection and saccade preparation by the frontal eye field was investigated in macaque monkeys performing a search-step task combining the classic double-step saccade task with visual search. Reward was earned for producing a saccade to a color singleton. On random trials the target and one distractor swapped locations before the saccade and monkeys were rewarded for shifting gaze to the new singleton location. A race model accounts for the probabilities and latencies of saccades to the initial and final singleton locations and provides a measure of the duration of a covert compensation process-target-step reaction time. When the target stepped out of a movement field, noncompensated saccades to the original location were produced when movement-related activity grew rapidly to a threshold. Compensated saccades to the final location were produced when the growth of the original movement-related activity was interrupted within target-step reaction time and was replaced by activation of other neurons producing the compensated saccade. When the target stepped into a receptive field, visual neurons selected the new target location regardless of the monkeys' response. When the target stepped out of a receptive field most visual neurons maintained the representation of the original target location, but a minority of visual neurons showed reduced activity. Chronometric analyses of the neural responses to the target step revealed that the modulation of visually responsive neurons and movement-related neurons occurred early enough to shift attention and saccade preparation from the old to the new target location. These findings indicate that visual activity in the frontal eye field signals the location of targets for orienting, whereas movement-related activity instantiates saccade preparation.

Observable signatures of a classical transition

NASA Astrophysics Data System (ADS)

Johnson, Matthew C.; Lin, Wei

2016-03-01

Eternal inflation arising from a potential landscape predicts that our universe is one realization of many possible cosmological histories. One way to access different cosmological histories is via the nucleation of bubble universes from a metastable false vacuum. Another way to sample different cosmological histories is via classical transitions, the creation of pocket universes through the collision between bubbles. Using relativistic numerical simulations, we examine the possibility of observationally determining if our observable universe resulted from a classical transition. We find that classical transitions produce spatially infinite, approximately open Friedman-Robertson-Walker universes. The leading set of observables in the aftermath of a classical transition are negative spatial curvature and a contribution to the Cosmic Microwave Background temperature quadrupole. The level of curvature and magnitude of the quadrupole are dependent on the position of the observer, and we determine the possible range of observables for two classes of single-scalar field models. For the first class, where the inflationary phase has a lower energy than the vacuum preceding the classical transition, the magnitude of the observed quadrupole generally falls to zero with distance from the collision while the spatial curvature grows to a constant. For the second class, where the inflationary phase has a higher energy than the vacuum preceding the classical transition, the magnitude of the observed quadrupole generically falls to zero with distance from the collision while the spatial curvature grows without bound. We find that the magnitude of the quadrupole and curvature grow with increasing centre of mass energy of the collision, and explore variations of the parameters in the scalar field lagrangian.

Observable signatures of a classical transition

DOE Office of Scientific and Technical Information (OSTI.GOV)

Johnson, Matthew C.; Lin, Wei, E-mail: mjohnson@perimeterinstitute.ca, E-mail: lewisweilin@gmail.com

2016-03-01

Eternal inflation arising from a potential landscape predicts that our universe is one realization of many possible cosmological histories. One way to access different cosmological histories is via the nucleation of bubble universes from a metastable false vacuum. Another way to sample different cosmological histories is via classical transitions, the creation of pocket universes through the collision between bubbles. Using relativistic numerical simulations, we examine the possibility of observationally determining if our observable universe resulted from a classical transition. We find that classical transitions produce spatially infinite, approximately open Friedman-Robertson-Walker universes. The leading set of observables in the aftermath ofmore » a classical transition are negative spatial curvature and a contribution to the Cosmic Microwave Background temperature quadrupole. The level of curvature and magnitude of the quadrupole are dependent on the position of the observer, and we determine the possible range of observables for two classes of single-scalar field models. For the first class, where the inflationary phase has a lower energy than the vacuum preceding the classical transition, the magnitude of the observed quadrupole generally falls to zero with distance from the collision while the spatial curvature grows to a constant. For the second class, where the inflationary phase has a higher energy than the vacuum preceding the classical transition, the magnitude of the observed quadrupole generically falls to zero with distance from the collision while the spatial curvature grows without bound. We find that the magnitude of the quadrupole and curvature grow with increasing centre of mass energy of the collision, and explore variations of the parameters in the scalar field lagrangian.« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Vostokov, S V

A new method for calculating an explicit form of the Hilbert pairing is proposed. It is used to calculate the Hilbert pairing in a classical local field and in a complete higher-dimensional field. Bibliography: 25 titles.

REEXAMINATION OF INDUCTION HEATING OF PRIMITIVE BODIES IN PROTOPLANETARY DISKS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Menzel, Raymond L.; Roberge, Wayne G., E-mail: menzer@rpi.edu, E-mail: roberw@rpi.edu

2013-10-20

We reexamine the unipolar induction mechanism for heating asteroids originally proposed in a classic series of papers by Sonett and collaborators. As originally conceived, induction heating is caused by the 'motional electric field' that appears in the frame of an asteroid immersed in a fully ionized, magnetized solar wind and drives currents through its interior. However, we point out that classical induction heating contains a subtle conceptual error, in consequence of which the electric field inside the asteroid was calculated incorrectly. The problem is that the motional electric field used by Sonett et al. is the electric field in themore » freely streaming plasma far from the asteroid; in fact, the motional field vanishes at the asteroid surface for realistic assumptions about the plasma density. In this paper we revisit and improve the induction heating scenario by (1) correcting the conceptual error by self-consistently calculating the electric field in and around the boundary layer at the asteroid-plasma interface; (2) considering weakly ionized plasmas consistent with current ideas about protoplanetary disks; and (3) considering more realistic scenarios that do not require a fully ionized, powerful T Tauri wind in the disk midplane. We present exemplary solutions for two highly idealized flows that show that the interior electric field can either vanish or be comparable to the fields predicted by classical induction depending on the flow geometry. We term the heating driven by these flows 'electrodynamic heating', calculate its upper limits, and compare them to heating produced by short-lived radionuclides.« less

Promoting Collaborative Playful Experimentation through Group Playing by Ear in Higher Education

ERIC Educational Resources Information Center

Varvarigou, Maria

2017-01-01

A group of 46, first-year, primarily classically trained, undergraduate students took part in an exploratory research study on Group Ear Playing (GEP) in higher education. The students attended the "Playing by Ear" component of the Practical Musicianship module, which adopts the materials and strategies on playing by ear in the…

An LED Solar Simulator for Student Labs

ERIC Educational Resources Information Center

González, Manuel I.

2017-01-01

Measuring voltage-current and voltage-power curves of a photovoltaic module is a nice experiment for high school and undergraduate students. In labs where real sunlight is not available this experiment requires a solar simulator. A prototype of a simulator using LED lamps has been manufactured and tested, and a comparison with classical halogen…

Kinase Activity Studied in Living Cells Using an Immunoassay

ERIC Educational Resources Information Center

Bavec, Aljos?a

2014-01-01

This laboratory exercise demonstrates the use of an immunoassay for studying kinase enzyme activity in living cells. The advantage over the classical method, in which students have to isolate the enzyme from cell material and measure its activity in vitro, is that enzyme activity is modulated and measured in living cells, providing a more…

Task-Dependent Modulations of Prefrontal and Hippocampal Activity during Intrinsic Word Production

ERIC Educational Resources Information Center

Whitney, Carin; Weis, Susanne; Krings, Timo; Huber, Walter; Grossman, Murray; Kircher, Tilo

2009-01-01

Functional imaging studies of single word production have consistently reported activation of the lateral prefrontal and cingulate cortex. Its contribution has been shown to be sensitive to task demands, which can be manipulated by the degree of response specification. Compared with classical verbal fluency, free word association relies less on…

Cognitive Effort Is Modulated outside of the Explicit Awareness of Conflict Frequency: Evidence from Pupillometry

ERIC Educational Resources Information Center

Diede, Nathaniel T.; Bugg, Julie M.

2017-01-01

Classic theories of cognitive control conceptualized controlled processes as slow, strategic, and willful, with automatic processes being fast and effortless. The context-specific proportion compatibility (CSPC) effect, the reduction in the compatibility effect in a context (e.g., location) associated with a high relative to low likelihood of…

Teaching the Classics: The Origin of Species as a Case Study

NASA Astrophysics Data System (ADS)

Ruse, Michael

2013-09-01

Many (including the author) argue that reading the classics in the field should be part of a scientist's education. However, how you read the classics can be very different depending on whether you read them as a historian or as a practicing scientist. This point will be made by comparing two readings of Charles Darwin's Origin of Species, and by looking at the use that Stephen Jay Gould made of the history of science in his quest to promote his scientific ideas.

Computational Re-design of Synthetic Genetic Oscillators for Independent Amplitude and Frequency Modulation.

PubMed

Tomazou, Marios; Barahona, Mauricio; Polizzi, Karen M; Stan, Guy-Bart

2018-04-25

To perform well in biotechnology applications, synthetic genetic oscillators must be engineered to allow independent modulation of amplitude and period. This need is currently unmet. Here, we demonstrate computationally how two classic genetic oscillators, the dual-feedback oscillator and the repressilator, can be re-designed to provide independent control of amplitude and period and improve tunability-that is, a broad dynamic range of periods and amplitudes accessible through the input "dials." Our approach decouples frequency and amplitude modulation by incorporating an orthogonal "sink module" where the key molecular species are channeled for enzymatic degradation. This sink module maintains fast oscillation cycles while alleviating the translational coupling between the oscillator's transcription factors and output. We characterize the behavior of our re-designed oscillators over a broad range of physiologically reasonable parameters, explain why this facilitates broader function and control, and provide general design principles for building synthetic genetic oscillators that are more precisely controllable. Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.

Magnetic state selected by magnetic dipole interaction in the kagome antiferromagnet NaBa2Mn3F11

NASA Astrophysics Data System (ADS)

Hayashida, Shohei; Ishikawa, Hajime; Okamoto, Yoshihiko; Okubo, Tsuyoshi; Hiroi, Zenji; Avdeev, Maxim; Manuel, Pascal; Hagihala, Masato; Soda, Minoru; Masuda, Takatsugu

2018-02-01

We haved studied the ground state of the classical kagome antiferromagnet NaBa2Mn3F11 . Strong magnetic Bragg peaks observed for d spacings shorter than 6.0 Å were indexed by the propagation vector of k0=(0 ,0 ,0 ) . Additional peaks with weak intensities in the d -spacing range above 8.0 Å were indexed by the incommensurate vector of k1=[0.3209 (2 ) ,0.3209 (2 ) ,0 ] and k2=[0.3338 (4 ) ,0.3338 (4 ) ,0 ] . Magnetic structure analysis unveils a 120∘ structure with the tail-chase geometry having k0 modulated by the incommensurate vector. A classical calculation of the Heisenberg kagome antiferromagnet with antiferromagnetic second-neighbor interaction, for which the ground state a k0120∘ degenerated structure, reveals that the magnetic dipole-dipole (MDD) interaction including up to the fourth neighbor terms selects the tail-chase structure. The observed modulation of the tail-chase structure is attributed to a small perturbation such as the long-range MDD interaction or the interlayer interaction.

Insights into the molecular mechanism of action of Celastraceae sesquiterpenes as specific, non-transported inhibitors of human P-glycoprotein.

PubMed

Muñoz-Martínez, Francisco; Reyes, Carolina P; Pérez-Lomas, Antonio L; Jiménez, Ignacio A; Gamarro, Francisco; Castanys, Santiago

2006-01-01

Dihydro-beta-agarofuran sesquiterpenes from Celastraceae have been recently shown to bind to human P-glycoprotein (Pgp), functioning as specific, mixed-type inhibitors of its drug transport activity, as well as multidrug resistance (MDR) modulators in vitro. However, nothing is known about whether such compounds are themselves transported by Pgp, or whether they affect Pgp expression as well as its activity, or about the location of their binding site within the protein. We performed transport experiments with a newly synthesized fluorescent sesquiterpene derivative, which retains the anti-Pgp activity of its natural precursor. This probe was poorly transported by Pgp, MRP1, MRP2 and BCRP transporters, compared with classical MDR substrates. Moreover, Pgp did not confer cross-resistance to the most potent dihydro-beta-agarofurans, which did not affect Pgp expression levels in several MDR cell lines. Finally, we observed competitive and non-competitive interactions between one of such dihydro-beta-agarofurans (Mama12) and classical Pgp modulators such as cyclosporin A, verapamil, progesterone, vinblastine and GF120918. These findings suggest that multidrug ABC transporters do not confer resistance to dihydro-beta-agarofurans and could not affect their absorption and biodistribution in the body. Moreover, we mapped their binding site(s) within Pgp, which may prove useful for the rational design of improved modulators based on the structure of dihydro-beta-agarofurans.

Atom transistor from the point of view of nonequilibrium dynamics

NASA Astrophysics Data System (ADS)

Zhang, Z.; Dunjko, V.; Olshanii, M.

2015-12-01

We analyze the atom field-effect transistor scheme (Stickney et al 2007 Phys. Rev. A 75 013608) using the standard tools of quantum and classical nonequlilibrium dynamics. We first study the correspondence between the quantum and the mean-field descriptions of this system by computing, both ab initio and by using their mean-field analogs, the deviations from the Eigenstate Thermalization Hypothesis, quantum fluctuations, and the density of states. We find that, as far as the quantities that interest us, the mean-field model can serve as a semi-classical emulator of the quantum system. Then, using the mean-field model, we interpret the point of maximal output signal in our transistor as the onset of ergodicity—the point where the system becomes, in principle, able to attain the thermal values of the former integrals of motion, albeit not being fully thermalized yet.

Electron dynamics in solid state via time varying wavevectors

NASA Astrophysics Data System (ADS)

Khaneja, Navin

2018-06-01

In this paper, we study electron wavepacket dynamics in electric and magnetic fields. We rigorously derive the semiclassical equations of electron dynamics in electric and magnetic fields. We do it both for free electron and electron in a periodic potential. We do this by introducing time varying wavevectors k(t). In the presence of magnetic field, our wavepacket reproduces the classical cyclotron orbits once the origin of the Schröedinger equation is correctly chosen to be center of cyclotron orbit. In the presence of both electric and magnetic fields, our equations for wavepacket dynamics differ from classical Lorentz force equations. We show that in a periodic potential, on application of electric field, the electron wave function adiabatically follows the wavefunction of a time varying Bloch wavevector k(t), with its energies suitably shifted with time. We derive the effective mass equation and discuss conduction in conductors and insulators.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chu, S.; Wang, K.; Layton, E.

In this paper we accomplish three goals. First, we present new nonperturbative results of complex quasi-energies (shifts and widths) for several low-lying excited states of atomic H in strong fields, using the {ital L}{sup 2} non-Hermitian Floquet matrix technique. Second, we present a new nonperturbative {ital L}{sup 2} technique for the treatment of ac Stark shifts of arbitrary excited states. We found that all the Rydberg states in weak fields are upshifted and closely follow the quadratic field dependence described by the ponderomotive potential {ital e}{sup 2}{ital F}{sup 2}/4{ital mgw}{sup 2}. Large deviation from the ponderomotive shift and intricate level-shiftmore » behaviors, however, occur in strong fields. Finally, we present a classical nonperturbative treatment of the electronic motion in intense laser fields. We show that the spectral analysis of classical trajectories can provide detailed insights regarding the mechanisms responsible for the multiple-harmonic generation recently observed in high-intensity experiments.« less

Gut-CNS-Axis as Possibility to Modulate Inflammatory Disease Activity-Implications for Multiple Sclerosis.

PubMed

Fleck, Ann-Katrin; Schuppan, Detlef; Wiendl, Heinz; Klotz, Luisa

2017-07-14

In the last decade the role of environmental factors as modulators of disease activity and progression has received increasing attention. In contrast to classical environmental modulators such as exposure to sun-light or fine dust pollution, nutrition is an ideal tool for a personalized human intervention. Various studies demonstrate a key role of dietary factors in autoimmune diseases including Inflammatory Bowel Disease (IBD), rheumatoid arthritis or inflammatory central nervous system (CNS) diseases such as Multiple Sclerosis (MS). In this review we discuss the connection between diet and inflammatory processes via the gut-CNS-axis. This axis describes a bi-directional communication system and comprises neuronal signaling, neuroendocrine pathways and modulation of immune responses. Therefore, the gut-CNS-axis represents an emerging target to modify CNS inflammatory activity ultimately opening new avenues for complementary and adjunctive treatment of autoimmune diseases such as MS.

Heart Rate and Blood Pressure Variability under Moon, Mars and Zero Gravity Conditions During Parabolic Flights

NASA Astrophysics Data System (ADS)

Aerts, Wouter; Joosen, Pieter; Widjaja, Devy; Varon, Carolina; Vandeput, Steven; Van Huffel, Sabine; Aubert, Andre E.

2013-02-01

Gravity changes during partial-G parabolic flights (0g -0.16g - 0.38g) lead to changes in modulation of the autonomic nervous system (ANS), studied via the heart rate variability (HRV) and blood pressure variability (BPV). HRV and BPV were assessed via classical time and frequency domain measures. Mean systolic and diastolic blood pressure show both increasing trends towards higher gravity levels. The parasympathetic and sympathetic modulation show both an increasing trend with decreasing gravity, although the modulation is sympathetic predominant during reduced gravity. For the mean heart rate, a non-monotonic relation was found, which can be explained by the increased influence of stress on the heart rate. This study shows that there is a relation between changes in gravity and modulations in the ANS. With this in mind, countermeasures can be developed to reduce postflight orthostatic intolerance.

Magnetoelastoelectric coupling in core-shell nanoparticles enabling directional and mode-selective magnetic control of THz beam propagation

DOE PAGES

Dutta, Moumita; Prasankumar, Rohit Prativadi; Natarajan, Kamaraju; ...

2017-08-07

Magnetoelastoelectric coupling in an engineered biphasic multiferroic nanocomposite enables a novel magnetic field direction-defined propagation control of terahertz (THz) waves. These core–shell nanoparticles are comprised of a ferromagnetic cobalt ferrite core and a ferroelectric barium titanate shell. Furthermore, an assembly of these nanoparticles, when operated in external magnetic fields, exhibits a controllable amplitude modulation when the magnetic field is applied antiparallel to the THz wave propagation direction; yet the same assembly displays an additional phase modulation when the magnetic field is applied along the propagation direction. And while field-induced magnetostriction of the core leads to amplitude modulation, phase modulation ismore » a result of stress-mediated piezoelectricity of the outer ferroelectric shell.« less

Experimental Observation of a Generalized Thouless Pump with a Single Spin

NASA Astrophysics Data System (ADS)

Ma, Wenchao; Zhou, Longwen; Zhang, Qi; Li, Min; Cheng, Chunyang; Geng, Jianpei; Rong, Xing; Shi, Fazhan; Gong, Jiangbin; Du, Jiangfeng

2018-03-01

Adiabatic cyclic modulation of a one-dimensional periodic potential will result in quantized charge transport, which is termed the Thouless pump. In contrast to the original Thouless pump restricted by the topology of the energy band, here we experimentally observe a generalized Thouless pump that can be extensively and continuously controlled. The extraordinary features of the new pump originate from interband coherence in nonequilibrium initial states, and this fact indicates that a quantum superposition of different eigenstates individually undergoing quantum adiabatic following can also be an important ingredient unavailable in classical physics. The quantum simulation of this generalized Thouless pump in a two-band insulator is achieved by applying delicate control fields to a single spin in diamond. The experimental results demonstrate all principal characteristics of the generalized Thouless pump. Because the pumping in our system is most pronounced around a band-touching point, this work also suggests an alternative means to detect quantum or topological phase transitions.

Lateralized responses during covert attention are modulated by target eccentricity.

PubMed

Bahramisharif, Ali; Heskes, Tom; Jensen, Ole; van Gerven, Marcel A J

2011-03-10

Various studies have demonstrated that covert attention to different locations in the visual field can be used as a control signal for brain computer interfacing. It is well known that when covert attention is directed to the left visual hemifield, posterior alpha activity decreases in the right hemisphere while simultaneously increasing in the left hemisphere and vice versa. However, it remains unknown if and how the classical lateralization pattern depends on the eccentricity of the locations to which one attends. In this paper we study the effect of target eccentricity on the performance of a brain computer interface system that is driven by covert attention. Results show that the lateralization pattern becomes more pronounced as target eccentricity increases and suggest that in the current design the minimum eccentricity for having an acceptable classification performance for two targets at equal distance from fixation in opposite hemifields is about 6° of visual angle. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

Super-resolution imaging by resonant tunneling in anisotropic acoustic metamaterials.

PubMed

Liu, Aiping; Zhou, Xiaoming; Huang, Guoliang; Hu, Gengkai

2012-10-01

The resonant tunneling effects that could result in complete transmission of evanescent waves are examined in acoustic metamaterials of anisotropic effective mass. The tunneling conditions are first derived for the metamaterials composed of classical mass-in-mass structures. It is found that the tunneling transmission occurs when the total length of metamaterials is an integral number of half-wavelengths of the periodic Bloch wave. Due to the local resonance of building units of metamaterials, the Bloch waves are spatially modulated within the periodic structures, leading to the resonant tunneling occurring in the low-frequency region. The metamaterial slab lens with anisotropic effective mass is designed by which the physics of resonant tunneling and the features for evanescent field manipulations are examined. The designed lens interacts with evanescent waves in the way of the propagating wavenumber weakly dependent on the spatial frequency of evanescent waves. Full-wave simulations validate the imaging performance of the proposed lens with the spatial resolution beyond the diffraction limit.

Nonlinear elasticity in rocks: A comprehensive three-dimensional description

DOE PAGES

Lott, Martin; Remillieux, Marcel; Garnier, Vincent; ...

2017-07-17

Here we study theoretically and experimentally the mechanisms of nonlinear and nonequilibrium dynamics in geomaterials through dynamic acoustoelasticity testing. In the proposed theoretical formulation, the classical theory of nonlinear elasticity is extended to include the effects of conditioning. This formulation is adapted to the context of dynamic acoustoelasticity testing in which a low-frequency “pump” wave induces a strain field in the sample and modulates the propagation of a high-frequency “probe” wave. Experiments are conducted to validate the formulation in a long thin bar of Berea sandstone. Several configurations of the pump and probe are examined: the pump successively consists ofmore » the first longitudinal and first torsional mode of vibration of the sample while the probe is successively based on (pressure) $P$ and (shear) $S$ waves. The theoretical predictions reproduce many features of the elastic response observed experimentally, in particular, the coupling between nonlinear and nonequilibrium dynamics and the three-dimensional effects resulting from the tensorial nature of elasticity.« less

The Plasticity of Extinction: Contribution of the Prefrontal Cortex in Treating Addiction through Inhibitory Learning

PubMed Central

Gass, J. T.; Chandler, L. J.

2013-01-01

Theories of drug addiction that incorporate various concepts from the fields of learning and memory have led to the idea that classical and operant conditioning principles underlie the compulsiveness of addictive behaviors. Relapse often results from exposure to drug-associated cues, and the ability to extinguish these conditioned behaviors through inhibitory learning could serve as a potential therapeutic approach for those who suffer from addiction. This review will examine the evidence that extinction learning alters neuronal plasticity in specific brain regions and pathways. In particular, subregions of the prefrontal cortex (PFC) and their projections to other brain regions have been shown to differentially modulate drug-seeking and extinction behavior. Additionally, there is a growing body of research demonstrating that manipulation of neuronal plasticity can alter extinction learning. Therefore, the ability to alter plasticity within areas of the PFC through pharmacological manipulation could facilitate the acquisition of extinction and provide a novel intervention to aid in the extinction of drug-related memories. PMID:23750137

[Does music influence visual perception in campimetric measurements of the visual field?].

PubMed

Gall, Carolin; Geier, Jens-Stefan; Sabel, Bernhard A; Kasten, Erich

2009-01-01

21 subjects (mean age 28,4 +/- 10,9, M +/- SD) without any damage of the visual system were examined with computer-based campimetric tests of near threshold stimulus detection whereby an artificial tunnel vision was induced. Campimetry was performed in four trials in randomized order using a within-subjects-design: 1. classical music, 2. Techno music, 3. music for relaxation and 4. no music. Results were slightly better in all music conditions. Performance was best when subjects were listening to Techno music. The average increase of correctly recognized stimuli and fixation controls amounted to 3 %. To check the stability of the effects 9 subjects were tested three times. A moderating influence of personality traits and habits of listening to music was tested but could not be found. We conclude that music has at least no negative influence on performance in the campimetric measurement. Reasons for the positive effects of music can be seen in a general increase of vigilance and a modulation of perceptual thresholds.

Quantum corrections to Bekenstein-Hawking black hole entropy and gravity partition functions

NASA Astrophysics Data System (ADS)

Bytsenko, A. A.; Tureanu, A.

2013-08-01

Algebraic aspects of the computation of partition functions for quantum gravity and black holes in AdS3 are discussed. We compute the sub-leading quantum corrections to the Bekenstein-Hawking entropy. It is shown that the quantum corrections to the classical result can be included systematically by making use of the comparison with conformal field theory partition functions, via the AdS3/CFT2 correspondence. This leads to a better understanding of the role of modular and spectral functions, from the point of view of the representation theory of infinite-dimensional Lie algebras. Besides, the sum of known quantum contributions to the partition function can be presented in a closed form, involving the Patterson-Selberg spectral function. These contributions can be reproduced in a holomorphically factorized theory whose partition functions are associated with the formal characters of the Virasoro modules. We propose a spectral function formulation for quantum corrections to the elliptic genus from supergravity states.

Design Considerations of a Novel Two-Beam Accelerator

NASA Astrophysics Data System (ADS)

Luginsland, John William

This thesis reports the design study of a new type of charged particle accelerator called the Twobetron. The accelerator consists of two beams of electrons traveling through a series of pillbox cavities. The power of a high current annular beam excites an electromagnetic mode in the cavities, which, in turn, drives a low current on-axis pencil beam to high energy. We focus on the design considerations that would make use of existing pulsed power systems, for a proof-of-principle experiment. Potential applications of this new device include radiotherapy, materials processing, and high energy accelerators. The first phase of the research involves analytic description of the accelerating process. This reveals the problem of phase slippage. Derbenev's proposed cure of beam radius modulation is analyzed. Further studies include the effect of initial phase and secondary beam loading. Scaling laws to characterize the Twobetron's performance are derived. Computer simulation is performed to produce a self-consistent analysis of the dynamics of the space charge and its interaction with the accelerator structure. Particle -in-cell simulations answer several questions concerning beam stability, cavity modes, and the nature of the structure. Specifically, current modulation on the primary beam is preserved in the simulations. However, these simulations also revealed that mode competition and significant cavity coupling are serious issues that need to be addressed. Also considered is non-axisymmetric instability on the driver beam of the Twobetron, in particular, the beam breakup instability (BBU), which is known to pose a serious threat to linear accelerators in general. We extend the classical analysis of BBU to annular beams. The effect of higher order non-axisymmetric modes is also examined. It is shown that annular beams are more stable than pencil beams to BBU in general. Our analysis also reveals that the rf magnetic field is more important than the rf electric field in contributing to BBU growth. We next address the issue of primary beam modulation. Both particle-in-cell and analytic investigation showed that the usual relativistic klystron amplifiers (RKA) mechanism cannot provide full beam modulation at convenient levels of external rf drive. However, the recent discovery at the Air Force Phillips Laboratory of the injection locked relativistic klystron oscillator suggests that electromagnetic feedback between the driver cavity and the booster cavity might significantly enhance the current modulation. A simple model is constructed to analyze this cavity coupling and its mutual interaction with the primary beam. Quantitative agreement is found between our model and the Phillips Laboratory experiments. This analysis suggests that significant current modulation on the primary beam may be achieved with low level external rf drive.

Fixed-Charge Atomistic Force Fields for Molecular Dynamics Simulations in the Condensed Phase: An Overview.

PubMed

Riniker, Sereina

2018-03-26

In molecular dynamics or Monte Carlo simulations, the interactions between the particles (atoms) in the system are described by a so-called force field. The empirical functional form of classical fixed-charge force fields dates back to 1969 and remains essentially unchanged. In a fixed-charge force field, the polarization is not modeled explicitly, i.e. the effective partial charges do not change depending on conformation and environment. This simplification allows, however, a dramatic reduction in computational cost compared to polarizable force fields and in particular quantum-chemical modeling. The past decades have shown that simulations employing carefully parametrized fixed-charge force fields can provide useful insights into biological and chemical questions. This overview focuses on the four major force-field families, i.e. AMBER, CHARMM, GROMOS, and OPLS, which are based on the same classical functional form and are continuously improved to the present day. The overview is aimed at readers entering the field of (bio)molecular simulations. More experienced users may find the comparison and historical development of the force-field families interesting.

A concise introduction to Colombeau generalized functions and their applications in classical electrodynamics

NASA Astrophysics Data System (ADS)

Gsponer, Andre

2009-01-01

The objective of this introduction to Colombeau algebras of generalized functions (in which distributions can be freely multiplied) is to explain in elementary terms the essential concepts necessary for their application to basic nonlinear problems in classical physics. Examples are given in hydrodynamics and electrodynamics. The problem of the self-energy of a point electric charge is worked out in detail: the Coulomb potential and field are defined as Colombeau generalized functions, and integrals of nonlinear expressions corresponding to products of distributions (such as the square of the Coulomb field and the square of the delta function) are calculated. Finally, the methods introduced in Gsponer (2007 Eur. J. Phys. 28 267, 2007 Eur. J. Phys. 28 1021 and 2007 Eur. J. Phys. 28 1241), to deal with point-like singularities in classical electrodynamics are confirmed.

The origin of three-cocycles in quantum field theory

NASA Astrophysics Data System (ADS)

Carey, A. L.

1987-08-01

When quantising a classical field theory it is not automatic that a group of symmetries of the classical system is preserved as a symmetry of the quantum system. Apart from the phenomenon of symmetry breaking it can also happen (as in Faddeev's Gauss law anomaly) that only an extension of the classical group acts as a symmetry group of the quantum system. We show here that rather than signalling a failure of the associative law as has been suggested in the literature, the occurrence of a non-trivial three-cocycle on the local gauge group is an ``anomaly'' or obstruction to the existence of an extension of the local gauge group acting as a symmetry group of the quantum system. Permanent address: Department of Pure Mathematics, University of Adelaide, G.P.O. Box 498, Adelaide, SA 5000, Australia.

The serotonin 5-HT2C receptor and the non-addictive nature of classic hallucinogens.

PubMed

Canal, Clinton E; Murnane, Kevin S

2017-01-01

Classic hallucinogens share pharmacology as serotonin 5-HT 2A , 5-HT 2B , and 5-HT 2C receptor agonists. Unique among most other Schedule 1 drugs, they are generally non-addictive and can be effective tools in the treatment of addiction. Mechanisms underlying these attributes are largely unknown. However, many preclinical studies show that 5-HT 2C agonists counteract the addictive effects of drugs from several classes, suggesting this pharmacological property of classic hallucinogens may be significant. Drawing from a comprehensive analysis of preclinical behavior, neuroanatomy, and neurochemistry studies, this review builds rationale for this hypothesis, and also proposes a testable, neurobiological framework. 5-HT 2C agonists work, in part, by modulating dopamine neuron activity in the ventral tegmental area-nucleus accumbens (NAc) reward pathway. We argue that activation of 5-HT 2C receptors on NAc shell, GABAergic, medium spiny neurons inhibits potassium Kv1.x channels, thereby enhancing inhibitory activity via intrinsic mechanisms. Together with experiments that show that addictive drugs, such as cocaine, potentiate Kv1.x channels, thereby suppressing NAc shell GABAergic activity, this hypothesis provides a mechanism by which classic hallucinogen-mediated stimulation of 5-HT 2C receptors could thwart addiction. It also provides a potential reason for the non-addictive nature of classic hallucinogens.

Real-time dynamics of matrix quantum mechanics beyond the classical approximation

NASA Astrophysics Data System (ADS)

Buividovich, Pavel; Hanada, Masanori; Schäfer, Andreas

2018-03-01

We describe a numerical method which allows to go beyond the classical approximation for the real-time dynamics of many-body systems by approximating the many-body Wigner function by the most general Gaussian function with time-dependent mean and dispersion. On a simple example of a classically chaotic system with two degrees of freedom we demonstrate that this Gaussian state approximation is accurate for significantly smaller field strengths and longer times than the classical one. Applying this approximation to matrix quantum mechanics, we demonstrate that the quantum Lyapunov exponents are in general smaller than their classical counterparts, and even seem to vanish below some temperature. This behavior resembles the finite-temperature phase transition which was found for this system in Monte-Carlo simulations, and ensures that the system does not violate the Maldacena-Shenker-Stanford bound λL < 2πT, which inevitably happens for classical dynamics at sufficiently small temperatures.

Definitions from Pioneers in the Field.

ERIC Educational Resources Information Center

Saba, Farhad, Ed.

1999-01-01

Presents classical definitions and explanations of distance education selected from pioneers of the field or those who have made seminal contributions to the conceptualization of distance education and related fields. Discusses definitions by Desmond Keegan, Michael G. Moore, Borje Holmberg, and Otto Peters. (AEF)

Magnetically controlled terahertz modulator based on Fe3O4 nanoparticle ferrofluids

NASA Astrophysics Data System (ADS)

Liu, Xin; Xiong, Luyao; Yu, Xiang; He, Shuli; Zhang, Bo; Shen, Jingling

2018-03-01

A multifunctional terahertz (THz) wave modulator fabricated from Fe3O4 nanoparticle ferrofluids and metamaterials was characterized in externally applied magnetic fields. Specifically, modulation depths and frequency shifts by the wave modulators were examined. A 34% THz amplitude modulation depth was demonstrated and the absorption peak of the metamaterial induced a frequency shift of 33 GHz at low magnetic field intensities. It is anticipated that this device structure and its tunable properties will have many potential applications in THz filtering, modulation, and sensing.

Wavefront reconstruction from non-modulated pyramid wavefront sensor data using a singular value type expansion

NASA Astrophysics Data System (ADS)

Hutterer, Victoria; Ramlau, Ronny

2018-03-01

The new generation of extremely large telescopes includes adaptive optics systems to correct for atmospheric blurring. In this paper, we present a new method of wavefront reconstruction from non-modulated pyramid wavefront sensor data. The approach is based on a simplified sensor model represented as the finite Hilbert transform of the incoming phase. Due to the non-compactness of the finite Hilbert transform operator the classical theory for singular systems is not applicable. Nevertheless, we can express the Moore-Penrose inverse as a singular value type expansion with weighted Chebychev polynomials.

Modulation of oestrogen excretion profiles by adjuvant chemotherapy in pre- and postmenopausal breast cancer.

PubMed

Castagnetta, L; Traina, A; Ciaccio, M; Carruba, G; Polito, L; Di Carlo, A

1985-12-01

Modulation of steroid status by conventional chemotherapy was studied in 31 breast cancer patients receiving CMF and in 31 age-matched breast cancer patients without any therapy, taken as controls. This was achieved through the study of oestrogen excretion profiles using previously identified parameters and referring not only to classical but also to the "other", namely catechol and unusual, oestrogen metabolites. After CMF treatment the premenopausal patients exhibit a modified excretion pattern, mainly concerning a marked and significant reduction of classical oestrogens, as shown by pattern indices. Because there is evidence that oestriol metabolism is not markedly affected by CMF treatment, such a significant decrease in classical oestrogens must be attributed to the secretory function, presumably ovarian ab origine. To the contrary, after treatment, pattern indices show significantly higher median values in postmenopausal patients. Mean oestriol ratio values also display a significant increase, thus supporting the hypothesis that conventional cytotoxic drugs may act by enhancing oestrogen metabolic rates. In fact, the postmenopausal treated subgroup proved to have significantly higher excretion levels of most of the oestrogens considered to date. Surprisingly, E1 + E1-S fractions were strongly reduced in this subgroup and this leads to the suggestion of an increased steroid metabolic rate by CMF treatment. However, comparing 9 breast cancer patients, when having had both short-term and non-short-term CMF treatment, the effects on steroid excretion patterns appear to arise at an early stage.

NREL Adds Solar Array Field to Help Inform Consumers | NREL

Science.gov Websites

PV modules at NREL's new solar array field. Workers install PV modules just north of the NREL parking be Added Each Year Once completed, the new solar array field will house four rows of PV modules. The the lifetime of a PV system, and that increases the per-kilowatt-hour cost of generating solar

The Problem of Absolute Knowledge. Metaphysics as Intellectual Intuition in Classic Modern European Philosophy

ERIC Educational Resources Information Center

Torubarova, Tatyana V.

2016-01-01

Classic modern European philosophy explicate, reflect; leaving own history in fundamental metaphysical position, where the existence is understood as conscience. This position is representative in the process of historic development, transition of philosophical thought from R. Dekart to G. Hegel. It appears exactly the field of key metaphysical…

Three Perspectives on: Children's Classics in a Non-Classical Age

ERIC Educational Resources Information Center

Fadiman, Clifton

1972-01-01

Along with pioneering thrusts into new thematic territory for children's literature has come experimentation in form, style, and technique, even more marked in the field of illustration than in verbal narrative. This article serves as an introduction to contributions by English, French and American experts on children's literature. (Author/SJ)

Classics in What Sense?

ERIC Educational Resources Information Center

Camic, Charles

2008-01-01

They seem the perfect bookends for the social psychologist's collection of "classics" of the field. Two volumes, nearly identical in shape and weight and exactly a century old in 2008--each professing to usher "social psychology" into the world as they both place the hybrid expression square in their titles but then proceed to stake out the field…

The invariance of classical electromagnetism under Charge-conjugation, Parity and Time-reversal (CPT) transformations

NASA Technical Reports Server (NTRS)

Norbury, John W.

1989-01-01

The invariance of classical electromagnetism under charge-conjugation, parity, and time-reversal (CPT) is studied by considering the motion of a charged particle in electric and magnetic fields. Upon applying CPT transformations to various physical quantities and noting that the motion still behaves physically demonstrates invariance.

A classical treatment of the quadratic Zeeman effect in atomic hydrogen

NASA Astrophysics Data System (ADS)

Al-Laithy, M. A.; Farmer, C. M.; McDowell, M. R. C.

1985-03-01

A description of the non-relativistic classical motion of the electron of a hydrogen atom in the presence of a static magnetic field of arbitrary (non-relativistic) strength is given for arbitrary angular momentum. Applications are given to m = 0 and m = 3 at B = 26.877 kG.

Classic and Contemporary Readings in the Philosophy of Education. Second Edition

ERIC Educational Resources Information Center

Cahn, Steven M., Ed.

2011-01-01

Now even more affordably priced in its second edition, "Classic and Contemporary Readings in the Philosophy of Education" is ideal for undergraduate and graduate philosophy of education courses. Editor Steven M. Cahn, a highly respected contributor to the field, brings together writings by leading figures in the history of philosophy and…

Louis Guttman's Contributions to Classical Test Theory

ERIC Educational Resources Information Center

Zimmerman, Donald W.; Williams, Richard H.; Zumbo, Bruno D.; Ross, Donald

2005-01-01

This article focuses on Louis Guttman's contributions to the classical theory of educational and psychological tests, one of the lesser known of his many contributions to quantitative methods in the social sciences. Guttman's work in this field provided a rigorous mathematical basis for ideas that, for many decades after Spearman's initial work,…

Pi2 detection using Empirical Mode Decomposition (EMD)

NASA Astrophysics Data System (ADS)

Mieth, Johannes Z. D.; Frühauff, Dennis; Glassmeier, Karl-Heinz

2017-04-01

Empirical Mode Decomposition has been used as an alternative method to wavelet transformation to identify onset times of Pi2 pulsations in data sets of the Scandinavian Magnetometer Array (SMA). Pi2 pulsations are magnetohydrodynamic waves occurring during magnetospheric substorms. Almost always Pi2 are observed at substorm onset in mid to low latitudes on Earth's nightside. They are fed by magnetic energy release caused by dipolarization processes. Their periods lie between 40 to 150 seconds. Usually, Pi2 are detected using wavelet transformation. Here, Empirical Mode Decomposition (EMD) is presented as an alternative approach to the traditional procedure. EMD is a young signal decomposition method designed for nonlinear and non-stationary time series. It provides an adaptive, data driven, and complete decomposition of time series into slow and fast oscillations. An optimized version using Monte-Carlo-type noise assistance is used here. By displaying the results in a time-frequency space a characteristic frequency modulation is observed. This frequency modulation can be correlated with the onset of Pi2 pulsations. A basic algorithm to find the onset is presented. Finally, the results are compared to classical wavelet-based analysis. The use of different SMA stations furthermore allows the spatial analysis of Pi2 onset times. EMD mostly finds application in the fields of engineering and medicine. This work demonstrates the applicability of this method to geomagnetic time series.

The Institution of Sociological Theory in Canada.

PubMed

Guzman, Cinthya; Silver, Daniel

2018-02-01

Using theory syllabi and departmental data collected for three academic years, this paper investigates the institutional practice of theory in sociology departments across Canada. In particular, it examines the position of theory within the sociological curriculum, and how this varies among universities. Taken together, our analyses indicate that theory remains deeply institutionalized at the core of sociological education and Canadian sociologists' self-understanding; that theorists as a whole show some coherence in how they define themselves, but differ in various ways, especially along lines of region, intellectual background, and gender; that despite these differences, the classical versus contemporary heuristic largely cuts across these divides, as does the strongly ingrained position of a small group of European authors as classics of the discipline as a whole. Nevertheless, who is a classic remains an unsettled question, alternatives to the "classical versus contemporary" heuristic do exist, and theorists' syllabi reveal diverse "others" as potential candidates. Our findings show that the field of sociology is neither marked by universal agreement nor by absolute division when it comes to its theoretical underpinnings. To the extent that they reveal a unified field, the findings suggest that unity lies more in a distinctive form than in a distinctive content, which defines the space and structure of the field of sociology. © 2018 Canadian Sociological Association/La Société canadienne de sociologie.

Inertial effects in systems with magnetic charge

NASA Astrophysics Data System (ADS)

Armitage, N. P.

2018-05-01

This short article sets out some of the basic considerations that go into detecting the mass of quasiparticles with effective magnetic charge in solids. Effective magnetic charges may be appear as defects in particular magnetic textures. A magnetic monopole is a defect in this texture and as such these are not monopoles in the actual magnetic field B, but instead in the auxiliary field H. They may have particular properties expected for such quasiparticles such as magnetic charge and mass. This effective mass may-in principle-be detected in the same fashion that the mass is detected of other particles classically e.g. through their inertial response to time-dependent electromagnetic fields. I discuss this physics in the context of the "simple" case of the quantum spin ices, but aspects are broadly applicable. Based on extensions to Ryzkhin's model for classical spin ice, a hydrodynamic formulation can be given that takes into account inertial and entropic forces. Ultimately, a form for the susceptibility is obtained that is equivalent to the Rocard equation, which is a classic form used to account for inertial effects in the context of Debye-like relaxation.

Foundations of Quantum Mechanics: Derivation of a dissipative Schrödinger equation from first principles

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gonçalves, L.A.; Olavo, L.S.F., E-mail: olavolsf@gmail.com

Dissipation in Quantum Mechanics took some time to become a robust field of investigation after the birth of the field. The main issue hindering developments in the field is that the Quantization process was always tightly connected to the Hamiltonian formulation of Classical Mechanics. In this paper we present a quantization process that does not depend upon the Hamiltonian formulation of Classical Mechanics (although still departs from Classical Mechanics) and thus overcome the problem of finding, from first principles, a completely general Schrödinger equation encompassing dissipation. This generalized process of quantization is shown to be nothing but an extension ofmore » a more restricted version that is shown to produce the Schrödinger equation for Hamiltonian systems from first principles (even for Hamiltonian velocity dependent potential). - Highlights: • A Quantization process independent of the Hamiltonian formulation of quantum Mechanics is proposed. • This quantization method is applied to dissipative or absorptive systems. • A Dissipative Schrödinger equation is derived from first principles.« less

Impact of built-in fields and contact configuration on the characteristics of ultra-thin GaAs solar cells

DOE Office of Scientific and Technical Information (OSTI.GOV)

Aeberhard, Urs, E-mail: u.aeberhard@fz-juelich.de

2016-07-18

We discuss the effects of built-in fields and contact configuration on the photovoltaic characteristics of ultra-thin GaAs solar cells. The investigation is based on advanced quantum-kinetic simulations reaching beyond the standard semi-classical bulk picture concerning the consideration of charge carrier states and dynamics in complex potential profiles. The thickness dependence of dark and photocurrent in the ultra-scaled regime is related to the corresponding variation of both, the built-in electric fields and associated modification of the density of states, and the optical intensity in the films. Losses in open-circuit voltage and short-circuit current due to the leakage of electronically and opticallymore » injected carriers at minority carrier contacts are investigated for different contact configurations including electron and hole blocking barrier layers. The microscopic picture of leakage currents is connected to the effect of finite surface recombination velocities in the semi-classical description, and the impact of these non-classical contact regions on carrier generation and extraction is analyzed.« less

Nonlinear Fluid Model Of 3-D Field Effects In Tokamak Plasmas

NASA Astrophysics Data System (ADS)

Callen, J. D.; Hegna, C. C.; Beidler, M. T.

2017-10-01

Extended MHD codes (e.g., NIMROD, M3D-C1) are beginning to explore nonlinear effects of small 3-D magnetic fields on tokamak plasmas. To facilitate development of analogous physically understandable reduced models, a fluid-based dynamic nonlinear model of these added 3-D field effects in the base axisymmetric tokamak magnetic field geometry is being developed. The model incorporates kinetic-based closures within an extended MHD framework. Key 3-D field effects models that have been developed include: 1) a comprehensive modified Rutherford equation for the growth of a magnetic island that includes the classical tearing and NTM perturbed bootstrap current drives, externally applied magnetic field and current drives, and classical and neoclassical polarization current effects, and 2) dynamic nonlinear evolution of the plasma toroidal flow (radial electric field) in response to the 3-D fields. An application of this model to RMP ELM suppression precipitated by an ELM crash will be discussed. Supported by Office of Fusion Energy Sciences, Office of Science, Dept. of Energy Grants DE-FG02-86ER53218 and DE-FG02-92ER54139.

On the Ising character of the quantum-phase transition in LiHoF4

NASA Astrophysics Data System (ADS)

Skomski, R.

2016-05-01

It is investigated how a transverse magnetic field affects the quantum-mechanical character of LiHoF4, a system generally considered as a textbook example for an Ising-like quantum-phase transition. In small magnetic fields, the low-temperature behavior of the ions is Ising-like, involving the nearly degenerate low-lying Jz = ± 8 doublet. However, as the transverse field increases, there is a substantial admixture of states having |Jz| < 8. Near the quantum-phase-transition field, the system is distinctively non-Ising like, and all Jz eigenstates yield ground-state contributions of comparable magnitude. A classical analog to this mechanism is the micromagnetic single point in magnets with uniaxial anisotropy. Since Ho3+ has J = 8, the ion's behavior is reminiscent of the classical limit (J = ∞), but quantum corrections remain clearly visible.

Development of a large field-of-view KD potassium di-deuterium phosphate modulator: Center Director's Discretionary Fund

NASA Technical Reports Server (NTRS)

West, E. A.

1993-01-01

Magnetographs, which measure polarized light, allow solar astronomers to infer the magnetic field intensity on the Sun. The Marshall Space Flight Center (MSFC) Vector Magnetograph is such an imaging instrument. The instrument requires rapid modulation between polarization states to minimize seeing effects. The accuracy of those polarization measurements is dependent on stable modulators with small field-of-view errors. Although these devices are very important in ground-based telescopes, extending the field of view of electro-optical crystals such as KD*Ps (potassium di-deuterium phosphate) could encourage the development of these devices for other imaging applications. The work that was done at MSFC as part of the Center Director's Discretionary Fund (CDDF) to reduce the field-of-view errors of instruments that use KD*P modulators in their polarimeters is described.

Periodically modulated dark states

NASA Astrophysics Data System (ADS)

Han, Yingying; Zhang, Jun; Zhang, Wenxian

2018-04-01

Phenomena of electromagnetically induced transparency (PEIT) may be interpreted by the Autler-Townes Splitting (ATS), where the coupled states are split by the coupling laser field, or by the quantum destructive interference (QDI), where the atomic phases caused by the coupling laser and the probe laser field cancel. We propose modulated experiments to explore the PEIT in an alternative way by periodically modulating the coupling and the probe fields in a Λ-type three-level system initially in a dark state. Our analytical and numerical results rule out the ATS interpretation and show that the QDI interpretation is more appropriate for the modulated experiments. Interestingly, dark state persists in the double-modulation situation where control and probe fields never occur simultaneously, which is significant difference from the traditional dark state condition. The proposed experiments are readily implemented in atomic gases, artificial atoms in superconducting quantum devices, or three-level meta-atoms in meta-materials.

Modulated heat pulse propagation and partial transport barriers in chaotic magnetic fields

DOE Office of Scientific and Technical Information (OSTI.GOV)

Castillo-Negrete, Diego del; Blazevski, Daniel

2016-04-15

Direct numerical simulations of the time dependent parallel heat transport equation modeling heat pulses driven by power modulation in three-dimensional chaotic magnetic fields are presented. The numerical method is based on the Fourier formulation of a Lagrangian-Green's function method that provides an accurate and efficient technique for the solution of the parallel heat transport equation in the presence of harmonic power modulation. The numerical results presented provide conclusive evidence that even in the absence of magnetic flux surfaces, chaotic magnetic field configurations with intermediate levels of stochasticity exhibit transport barriers to modulated heat pulse propagation. In particular, high-order islands andmore » remnants of destroyed flux surfaces (Cantori) act as partial barriers that slow down or even stop the propagation of heat waves at places where the magnetic field connection length exhibits a strong gradient. Results on modulated heat pulse propagation in fully stochastic fields and across magnetic islands are also presented. In qualitative agreement with recent experiments in large helical device and DIII-D, it is shown that the elliptic (O) and hyperbolic (X) points of magnetic islands have a direct impact on the spatio-temporal dependence of the amplitude of modulated heat pulses.« less

Harmonic Analysis and Free Field Realization of the Takiff Supergroup of GL(1|1)

NASA Astrophysics Data System (ADS)

Babichenko, Andrei; Creutzig, Thomas

2015-08-01

Takiff superalgebras are a family of non semi-simple Lie superalgebras that are believed to give rise to a rich structure of indecomposable representations of associated conformal field theories. We consider the Takiff superalgebra of gl(1\\vert 1), especially we perform harmonic analysis for the corresponding supergroup. We find that every simple module appears as submodule of an infinite-dimensional indecomposable but reducible module. We lift our results to two free field realizations for the corresponding conformal field theory and construct some modules.

Planetary period modulations of Saturn's magnetotail current sheet during northern spring: Observations and modeling

NASA Astrophysics Data System (ADS)

Cowley, S. W. H.; Provan, G.

2017-06-01

We study Cassini magnetic field observations at Saturn on a sequence of passes through the near-equatorial magnetotail during 2015, focusing on dual modulation of the plasma/current sheet associated with northern and southern planetary period oscillations (PPOs). Previous study of inner magnetosphere PPOs during this northern spring interval showed that the southern system amplitude was generally half that of the northern during the first part of the year to late August, after which the southern amplitude weakened to less than one-fifth that of the northern. We examine four sequential tail passes in the earlier interval, during which prominent PPO-related tail field modulations were observed, with relative (beat) phases of the two PPO systems being near in phase, antiphase, and two opposite near-quadrature conditions. We find that the radial field displayed opposite "sawtooth" asymmetry modulations under opposite near-quadrature conditions, related to previous findings under equinoctial conditions with near-equal northern and southern PPO amplitudes, while modulations were near symmetric for in-phase and antiphase conditions, but with larger radial field modulations for in-phase and larger colatitudinal field modulations for antiphase. A simple physical mathematical model of dual modulation is developed, which provides reasonable correspondence with these data using one set of current sheet parameters while varying only the relative PPO phases, thus demonstrating that dual modulation can be discerned and modeled even when the northern and southern amplitudes differ by a factor of 2. No such effects were consistently discerned during the later interval when the amplitude ratio was >5.

Classical and quantum decay of oscillations: Oscillating self-gravitating real scalar field solitons

NASA Astrophysics Data System (ADS)

Page, Don N.

2004-07-01

The oscillating gravitational field of an oscillaton of finite mass M causes it to lose energy by emitting classical scalar field waves, but at a rate that is nonperturbatively tiny for small μ≡GMm/ħc, where m is the scalar field mass: dM/dt≈-3 797 437.776(c3/G)μ-2e-39.433 795 197/μ[1+O(μ)]. Oscillatons also decay by the quantum process of the annihilation of scalarons into gravitons, which is only perturbatively small in μ, giving by itself dM/dt≈-0.008 513 223 935(m2c2/ħ)μ5[1+O(μ2)]. Thus the quantum decay is faster than the classical one for μ≲39.4338/[ln(ħc/Gm2)+7 ln(1/μ)+19.9160]. The time for an oscillaton to decay away completely into free scalarons and gravitons is tdecay˜2ħ6c3/G5m11˜10324 yr(1 meV/mc2)11. Oscillatons of more than one real scalar field of the same mass generically asymptotically approach a static-geometry U(1) boson star configuration with μ=μ0, at the rate d(GM/c3)/dt≈[(C/μ4)e-α/μ+Q(m/mPl)2μ3](μ2-μ20), with μ0 depending on the magnitudes and relative phases of the oscillating fields, and with the same constants C, α, and Q given numerically above for the single-field case that is equivalent to μ0=0.

Investigating chaotic wake dynamics past a flapping airfoil and the role of vortex interactions behind the chaotic transition

NASA Astrophysics Data System (ADS)

Bose, Chandan; Sarkar, Sunetra

2018-04-01

The present study investigates the complex vortex interactions in two-dimensional flow-field behind a symmetric NACA0012 airfoil undergoing a prescribed periodic pitching-plunging motion in low Reynolds number regime. The flow-field transitions from periodic to chaotic through a quasi-periodic route as the plunge amplitude is gradually increased. This study unravels the role of the complex interactions that take place among the main vortex structures in making the unsteady flow-field transition from periodicity to chaos. The leading-edge separation plays a key role in providing the very first trigger for aperiodicity. Subsequent mechanisms like shredding, merging, splitting, and collision of vortices in the near-field that propagate and sustain the disturbance have also been followed and presented. These fundamental mechanisms are seen to give rise to spontaneous and irregular formation of new vortex couples at arbitrary locations, which are the primary agencies for sustaining chaos in the flow-field. The interactions have been studied for each dynamical state to understand the course of transition in the flow-field. The qualitative changes observed in the flow-field are manifestation of changes in the underlying dynamical system. The overall dynamics are established in the present study by means of robust quantitative measures derived from classical and non-classical tools from the dynamical system theory. As the present analysis involves a high fidelity multi-unknown system, non-classical dynamical tools such as recurrence-based time series methods are seen to be very efficient. Moreover, their application is novel in the context of pitch-plunge flapping flight.

Apparel Research Network (ARN) Apparel Order Processing Module (AOPM). Application Program for Management of Special Measurement Clothing Orders

DTIC Science & Technology

1997-09-30

Screen, abandoning changes. APPAREL ORDER PROCESSING MODULE FIELD USER MANUAL Ordering Official Screens The Ordering Official Screens are provided for...currendy selected Ordering Official will appear on the Ordering Official Information Screen. APPAREL ORDER PROCESSING MODULE FIELD USER MANUAL Ordering Official

Electrochemically Based Modules for Sterilization in the Field. Phase 2.

DTIC Science & Technology

1995-09-30

NO: DAMD 17-91-C-1105 TITLE: Electrochemically Based Modules for Sterilization in the Field PRINCIPAL INVESTIGATOR(S) : G. Duncan Hitchens, Ph.D. Tom...NUMBERS Electrochemically Based Modules for Sterilization in the Field 6. AUTHOR(S) DAMD17-91-C-1105 G. Duncan Hitchens, Ph.D. Tom C. Allen, Tom D. Rogers...of high concentration ozone as an alternative to ethylene oxide for use in medical sterilization systems. Evaluations of high concentration

Ultrafast Modulation of Semiconductor Lasers Through a Terahertz Field

NASA Technical Reports Server (NTRS)

Ning, Cun-Zheng; Hughes, Steven; Citrin, David

1998-01-01

We demonstrate, by means of numerical simulation, a new mechanism to modulate and switch semiconductor lasers at THz and sub-THz frequency rates. A sinusoidal terahertz field applied to a semiconductor laser heats the electron-hole plasma and consequently modifies the optical susceptibility. This allows an almost linear modulation of the output power of tile semiconductor laser and leads to a faithful reproduction of the terahertz-field waveform in the emitted laser intensity.

A Cognitive Model Based on Neuromodulated Plasticity

PubMed Central

Ruan, Xiaogang

2016-01-01

Associative learning, including classical conditioning and operant conditioning, is regarded as the most fundamental type of learning for animals and human beings. Many models have been proposed surrounding classical conditioning or operant conditioning. However, a unified and integrated model to explain the two types of conditioning is much less studied. Here, a model based on neuromodulated synaptic plasticity is presented. The model is bioinspired including multistored memory module and simulated VTA dopaminergic neurons to produce reward signal. The synaptic weights are modified according to the reward signal, which simulates the change of associative strengths in associative learning. The experiment results in real robots prove the suitability and validity of the proposed model. PMID:27872638

Asymmetrical flow field-flow fractionation with multi-angle light scattering and quasi-elastic light scattering for characterization of polymersomes: comparison with classical techniques.

PubMed

Till, Ugo; Gaucher-Delmas, Mireille; Saint-Aguet, Pascale; Hamon, Glenn; Marty, Jean-Daniel; Chassenieux, Christophe; Payré, Bruno; Goudounèche, Dominique; Mingotaud, Anne-Françoise; Violleau, Frédéric

2014-12-01

Polymersomes formed from amphiphilic block copolymers, such as poly(ethyleneoxide-b-ε-caprolactone) (PEO-b-PCL) or poly(ethyleneoxide-b-methylmethacrylate), were characterized by asymmetrical flow field-flow fractionation coupled with quasi-elastic light scattering (QELS), multi-angle light scattering (MALS), and refractive index detection, leading to the determination of their size, shape, and molecular weight. The method was cross-examined with more classical ones, like batch dynamic and static light scattering, electron microscopy, and atomic force microscopy. The results show good complementarities between all the techniques; asymmetrical flow field-flow fractionation being the most pertinent one when the sample exhibits several different types of population.

Part 1: Classical laser. Part 2: The effect of velocity changing collisions on the output of a gas laser. Ph.D. Thesis

NASA Technical Reports Server (NTRS)

Borenstein, M.

1972-01-01

A classical model for laser action is discussed, in which an active medium consisting of anharmonic oscillators interacts with an electromagnetic field in a resonant cavity. Comparison with the case of a medium consisting of harmonic oscillators shows the significance of nonlinearities for producing self-sustained oscillations in the radiation field. A theoretical model is presented for the pressure dependence of the intensity of a gas laser, in which only velocity-changing collisions with foreign gas atoms are included. A collision model for hard sphere, repulsive interactions was derived. Collision theory was applied to a third-order expansion of the polarization in powers of the cavity electric field (weak signal theory).

Properties of the Boltzmann equation in the classical approximation

DOE PAGES

Epelbaum, Thomas; Gelis, François; Tanji, Naoto; ...

2014-12-30

We examine the Boltzmann equation with elastic point-like scalar interactions in two different versions of the the classical approximation. Although solving numerically the Boltzmann equation with the unapproximated collision term poses no problem, this allows one to study the effect of the ultraviolet cutoff in these approximations. This cutoff dependence in the classical approximations of the Boltzmann equation is closely related to the non-renormalizability of the classical statistical approximation of the underlying quantum field theory. The kinetic theory setup that we consider here allows one to study in a much simpler way the dependence on the ultraviolet cutoff, since onemore » has also access to the non-approximated result for comparison.« less

Evaluation and Field Assessment of Bifacial Photovoltaic Module Power Rating Methodologies

DOE Office of Scientific and Technical Information (OSTI.GOV)

Deline, Chris; MacAlpine, Sara; Marion, Bill

2016-11-21

1-sun power ratings for bifacial modules are currently undefined. This is partly because there is no standard definition of rear irradiance given 1000 Wm-2 on the front. Using field measurements and simulations, we evaluate multiple deployment scenarios for bifacial modules and provide details on the amount of irradiance that could be expected. A simplified case that represents a single module deployed under conditions consistent with existing 1-sun irradiance standards leads to a bifacial reference condition of 1000 Wm-2 Gfront and 130-140 Wm-2 Grear. For fielded systems of bifacial modules, Grear magnitude and spatial uniformity will be affected by self-shade frommore » adjacent modules, varied ground cover, and ground-clearance height. A standard measurement procedure for bifacial modules is also currently undefined. A proposed international standard is under development, which provides the motivation for this work. Here, we compare outdoor field measurements of bifacial modules with irradiance on both sides with proposed indoor test methods where irradiance is only applied to one side at a time. The indoor method has multiple advantages, including controlled and repeatable irradiance and thermal environment, along with allowing the use of conventional single-sided flash test equipment. The comparison results are promising, showing that the indoor and outdoor methods agree within 1%-2% for multiple rear-irradiance conditions and bifacial module types.« less

Evaluation and Field Assessment of Bifacial Photovoltaic Module Power Rating Methodologies: Preprint

DOE Office of Scientific and Technical Information (OSTI.GOV)

Deline, Chris; MacAlpine, Sara; Marion, Bill

2016-06-16

1-sun power ratings for bifacial modules are currently undefined. This is partly because there is no standard definition of rear irradiance given 1000 Wm-2 on the front. Using field measurements and simulations, we evaluate multiple deployment scenarios for bifacial modules and provide details on the amount of irradiance that could be expected. A simplified case that represents a single module deployed under conditions consistent with existing 1-sun irradiance standards leads to a bifacial reference condition of 1000 Wm-2 Gfront and 130-140 Wm-2 Grear. For fielded systems of bifacial modules, Grear magnitude and spatial uniformity will be affected by self-shade frommore » adjacent modules, varied ground cover, and ground-clearance height. A standard measurement procedure for bifacial modules is also currently undefined. A proposed international standard is under development, which provides the motivation for this work. Here, we compare outdoor field measurements of bifacial modules with irradiance on both sides with proposed indoor test methods where irradiance is only applied to one side at a time. The indoor method has multiple advantages, including controlled and repeatable irradiance and thermal environment, along with allowing the use of conventional single-sided flash test equipment. The comparison results are promising, showing that the indoor and outdoor methods agree within 1%-2% for multiple rear-irradiance conditions and bifacial module types.« less

Parathyroid Hormone-Related Peptide: A Novel Endocrine Cardioprotective "Conditioning Mimetic".

PubMed

Datta, Tanuka; Przyklenk, Karin; Datta, Nabanita S

2017-11-01

An as-yet limited body of evidence suggests that calcium-regulating endocrine hormones-in particular, parathyroid hormone-related peptide (PTHrP)-may have unappreciated cardioprotective effects. The current review focuses on the concept that PTHrP may, via modulation of classic cardioprotective signaling pathways, provide a novel strategy to attenuate myocardial ischemia-reperfusion injury.

Electrophoresis in strong electric fields.

PubMed

Barany, Sandor

2009-01-01

Two kinds of non-linear electrophoresis (ef) that can be detected in strong electric fields (several hundred V/cm) are considered. The first ("classical" non-linear ef) is due to the interaction of the outer field with field-induced ionic charges in the electric double layer (EDL) under conditions, when field-induced variations of electrolyte concentration remain to be small comparatively to its equilibrium value. According to the Shilov theory, the non-linear component of the electrophoretic velocity for dielectric particles is proportional to the cubic power of the applied field strength (cubic electrophoresis) and to the second power of the particles radius; it is independent of the zeta-potential but is determined by the surface conductivity of particles. The second one, the so-called "superfast electrophoresis" is connected with the interaction of a strong outer field with a secondary diffuse layer of counterions (space charge) that is induced outside the primary (classical) diffuse EDL by the external field itself because of concentration polarization. The Dukhin-Mishchuk theory of "superfast electrophoresis" predicts quadratic dependence of the electrophoretic velocity of unipolar (ionically or electronically) conducting particles on the external field gradient and linear dependence on the particle's size in strong electric fields. These are in sharp contrast to the laws of classical electrophoresis (no dependence of V(ef) on the particle's size and linear dependence on the electric field gradient). A new method to measure the ef velocity of particles in strong electric fields is developed that is based on separation of the effects of sedimentation and electrophoresis using videoimaging and a new flowcell and use of short electric pulses. To test the "classical" non-linear electrophoresis, we have measured the ef velocity of non-conducting polystyrene, aluminium-oxide and (semiconductor) graphite particles as well as Saccharomice cerevisiae yeast cells as a function of the electric field strength, particle size, electrolyte concentration and the adsorbed polymer amount. It has been shown that the electrophoretic velocity of the particles/cells increases with field strength linearly up to about 100 and 200 V/cm (for cells) without and with adsorbed polymers both in pure water and in electrolyte solutions. In line with the theoretical predictions, in stronger fields substantial non-linear effects were recorded (V(ef)~E(3)). The ef velocity of unipolar ion-type conducting (ion-exchanger particles and fibres), electron-type conducting (magnesium and Mg/Al alloy) and semiconductor particles (graphite, activated carbon, pyrite, molybdenite) increases significantly with the electric field (V(ef)~E(2)) and the particle's size but is almost independent of the ionic strength. These trends are inconsistent with Smoluchowski's equation for dielectric particles, but are consistent with the Dukhin-Mishchuk theory of superfast electrophoresis.

Using the Binary Phase-Field Crystal Model to Describe Non-Classical Nucleation Pathways in Gold Nanoparticles

NASA Astrophysics Data System (ADS)

Smith, Nathan; Provatas, Nikolas

Recent experimental work has shown that gold nanoparticles can precipitate from an aqueous solution through a non-classical, multi-step nucleation process. This multi-step process begins with spinodal decomposition into solute-rich and solute-poor liquid domains followed by nucleation from within the solute-rich domains. We present a binary phase-field crystal theory that shows the same phenomology and examine various cross-over regimes in the growth and coarsening of liquid and solid domains. We'd like to the thank Canada Research Chairs (CRC) program for funding this work.

Thermodynamic Bounds on Precision in Ballistic Multiterminal Transport

NASA Astrophysics Data System (ADS)

Brandner, Kay; Hanazato, Taro; Saito, Keiji

2018-03-01

For classical ballistic transport in a multiterminal geometry, we derive a universal trade-off relation between total dissipation and the precision, at which particles are extracted from individual reservoirs. Remarkably, this bound becomes significantly weaker in the presence of a magnetic field breaking time-reversal symmetry. By working out an explicit model for chiral transport enforced by a strong magnetic field, we show that our bounds are tight. Beyond the classical regime, we find that, in quantum systems far from equilibrium, the correlated exchange of particles makes it possible to exponentially reduce the thermodynamic cost of precision.

Field test of classical symmetric encryption with continuous variables quantum key distribution.

PubMed

Jouguet, Paul; Kunz-Jacques, Sébastien; Debuisschert, Thierry; Fossier, Simon; Diamanti, Eleni; Alléaume, Romain; Tualle-Brouri, Rosa; Grangier, Philippe; Leverrier, Anthony; Pache, Philippe; Painchault, Philippe

2012-06-18

We report on the design and performance of a point-to-point classical symmetric encryption link with fast key renewal provided by a Continuous Variable Quantum Key Distribution (CVQKD) system. Our system was operational and able to encrypt point-to-point communications during more than six months, from the end of July 2010 until the beginning of February 2011. This field test was the first demonstration of the reliability of a CVQKD system over a long period of time in a server room environment. This strengthens the potential of CVQKD for information technology security infrastructure deployments.

Improved contour detection model with spatial summation properties based on nonclassical receptive field

NASA Astrophysics Data System (ADS)

Lin, Chuan; Xu, Guili; Cao, Yijun; Liang, Chenghua; Li, Ya

2016-07-01

The responses of cortical neurons to a stimulus in a classical receptive field (CRF) can be modulated by stimulating the non-CRF (nCRF) of neurons in the primary visual cortex (V1). In the very early stages (at around 40 ms), a neuron in V1 exhibits strong responses to a small set of stimuli. Later, however (after 100 ms), the neurons in V1 become sensitive to the scene's global organization. As per these visual cortical mechanisms, a contour detection model based on the spatial summation properties is proposed. Unlike in previous studies, the responses of the nCRF to the higher visual cortex that results in the inhibition of the neuronal responses in the primary visual cortex by the feedback pathway are considered. In this model, the individual neurons in V1 receive global information from the higher visual cortex to participate in the inhibition process. Computationally, global Gabor energy features are involved, leading to the more coherent physiological characteristics of the nCRF. We conducted an experiment where we compared our model with those proposed by other researchers. Our model explains the role of the mutual inhibition of neurons in V1, together with an approach for object recognition in machine vision.

Design and implementation of new control room system in Damavand tokamak

NASA Astrophysics Data System (ADS)

Rasouli, H.; Zamanian, H.; Gheidi, M.; Kheiri-Fard, M.; Kouhi, A.

2017-07-01

The aim of this paper is design and implementation of an up-to-date control room. The previous control room had a lot of constraints and it was not apposite to the sophisticated diagnostic systems as well as to the modern control and multivariable systems. Although it provided the best output for the considered experiments and implementing offline algorithms among all similar plants, it needed to be developed to provide more capability for complex algorithm mechanisms and this work introduces our efforts in this area. Accordingly, four leading systems were designed and implemented, including real-time control system, online Data Acquisition System (DAS), offline DAS, monitoring and data transmission system. In the control system, three real-time control modules were established based on Digital Signal Processor (DSP). Thanks to them, implementation of the classic and linear and nonlinear intelligent controllers was possible to control the plasma position and its elongation. Also, online DAS was constructed in two modules. Using them, voltages and currents of charge for the capacitor banks and pressure of different parts in vacuum vessel were measured and monitored. Likewise, by real-time processing of the online data, the safety protocol of plant performance was accomplished. In addition, the offline DAS was organized in 13 modules based on Field Programmable Gate Array (FPGA). This system can be used for gathering all diagnostic, control, and performance data in 156 channels. Data transmission system and storing mechanism in the server was provided by data transmitting network and MDSplus standard protocol. Moreover, monitoring software was designed so that it could display the required plots for physical analyses. Taking everything into account, this new platform can improve the quality and quantity of research activities in plasma physics for Damavand tokamak.

Transcranial direct current stimulation improves seizure control in patients with Rasmussen encephalitis.

PubMed

Tekturk, Pinar; Erdogan, Ezgi Tuna; Kurt, Adnan; Kocagoncu, Ece; Kucuk, Zeynep; Kinay, Demet; Yapici, Zuhal; Aksu, Serkan; Baykan, Betul; Karamursel, Sacit

2016-03-01

Rasmussen encephalitis is associated with severe seizures that are unresponsive to antiepileptic drugs, as well as immunosuppressants. Transcranial direct current stimulation (t-DCS) is a non-invasive and safe method tried mostly for focal epilepsies with different aetiologies. To date, there is only one published study with two case reports describing the effect of t-DCS in Rasmussen encephalitis. Our aim was to investigate the effect of t-DCS on seizures in Rasmussen encephalitis and to clarify its safety. Five patients (mean age: 19; three females), diagnosed with Rasmussen encephalitis were included in this study. Patients received first cathodal, then anodal (2 mA for 30 minutes on three consecutive days for non-sham stimulations), and finally sham stimulation with two-month intervals, respectively. Three patients received classic (DC) cathodal t-DCS whereas two patients received cathodal stimulation with amplitude modulation at 12 Hz. Afterwards, all patients received anodal stimulation with amplitude modulation at 12 Hz. In the last part of the trial, sham stimulation (a 60-second stimulation with gradually decreasing amplitude to zero in the last 15 seconds) was applied to three patients. Maximum current density was 571 mA/m2 using 70 mm x 50 mm wet sponge electrodes with 2-mA maximum, current controlled stimulator, and maximum charge density was 1028 C/m2 for a 30-minute stimulation period. After cathodal stimulation, all but one patient had a greater than 50% decrease in seizure frequency. Two patients who received modulated cathodal t-DCS had better results. The longest positive effect lasted for one month. A second trial with modulated anodal stimulation and a third with sham stimulation were not effective. No adverse effect was reported with all types of stimulations. Both classic and modulated cathodal t-DCS may be suitable alternative methods for improving seizure outcome in Rasmussen encephalitis patients.

Phantom of the Hartle–Hawking instanton: Connecting inflation with dark energy

DOE PAGES

Chen, Pisin; Qiu, Taotao; Yeom, Dong -han

2016-02-20

If the Hartle–Hawking wave function is the correct boundary condition of our universe, the history of our universe will be well approximated by an instanton. Although this instanton should be classicalized at infinity, as long as we are observing a process of each history, we may detect a non-classicalized part of field combinations. When we apply it to a dark energy model, this non-classicalized part of fields can be well embedded to a quintessence and a phantom model, i.e., a quintom model. Because of the property of complexified instantons, the phantomness will be naturally free from a big rip singularity.more » This phantomness does not cause perturbative instabilities, as it is an effect emergent from the entire wave function. Lastly, our work may thus provide a theoretical basis for the quintom models, whose equation of state can cross the cosmological constant boundary phenomenologically.« less

Phantom of the Hartle-Hawking instanton: connecting inflation with dark energy

NASA Astrophysics Data System (ADS)

Chen, Pisin; Qiu, Taotao; Yeom, Dong-han

2016-02-01

If the Hartle-Hawking wave function is the correct boundary condition of our universe, the history of our universe will be well approximated by an instanton. Although this instanton should be classicalized at infinity, as long as we are observing a process of each history, we may detect a non-classicalized part of field combinations. When we apply it to a dark energy model, this non-classicalized part of fields can be well embedded to a quintessence and a phantom model, i.e., a quintom model. Because of the property of complexified instantons, the phantomness will be naturally free from a big rip singularity. This phantomness does not cause perturbative instabilities, as it is an effect emergent from the entire wave function. Our work may thus provide a theoretical basis for the quintom models, whose equation of state can cross the cosmological constant boundary phenomenologically.

Rydberg Dipole Antennas

NASA Astrophysics Data System (ADS)

Stack, Daniel; Rodenburg, Bradon; Pappas, Stephen; Su, Wangshen; St. John, Marc; Kunz, Paul; Simon, Matt; Gordon, Joshua; Holloway, Christopher

2017-04-01

Measurements of microwave frequency electric fields by traditional methods (i.e. engineered antennas) have limited sensitivity and can be difficult to calibrate properly. A useful tool to address this problem are highly-excited (Rydberg) neutral atoms which have very large electric-dipole moments and many dipole-allowed transitions in the range of 1-500 GHz. Using Rydberg states, it is possible to sensitively probe the electric field in this frequency range using the combination of two quantum interference phenomena: electromagnetically induced transparency and the Autler-Townes effect. This atom-light interaction can be modeled by the classical description of a harmonically bound electron. The classical damped, driven, coupled-oscillators model yields significant insights into the deep connections between classical and quantum physics. We will present a detailed experimental analysis of the noise processes in making such measurements in the laboratory and discuss the prospects for building a practical atomic microwave receiver.

Generation of steady entanglement via unilateral qubit driving in bad cavities.

PubMed

Jin, Zhao; Su, Shi-Lei; Zhu, Ai-Dong; Wang, Hong-Fu; Shen, Li-Tuo; Zhang, Shou

2017-12-15

We propose a scheme for generating an entangled state for two atoms trapped in two separate cavities coupled to each other. The scheme is based on the competition between the unitary dynamics induced by the classical fields and the collective decays induced by the dissipation of two non-local bosonic modes. In this scheme, only one qubit is driven by external classical fields, whereas the other need not be manipulated via classical driving. This is meaningful for experimental implementation between separate nodes of a quantum network. The steady entanglement can be obtained regardless of the initial state, and the robustness of the scheme against parameter fluctuations is numerically demonstrated. We also give an analytical derivation of the stationary fidelity to enable a discussion of the validity of this regime. Furthermore, based on the dissipative entanglement preparation scheme, we construct a quantum state transfer setup with multiple nodes as a practical application.

q-bosons and the q-analogue quantized field

NASA Technical Reports Server (NTRS)

Nelson, Charles A.

1995-01-01

The q-analogue coherent states are used to identify physical signatures for the presence of a 1-analogue quantized radiation field in the q-CS classical limits where the absolute value of z is large. In this quantum-optics-like limit, the fractional uncertainties of most physical quantities (momentum, position, amplitude, phase) which characterize the quantum field are O(1). They only vanish as O(1/absolute value of z) when q = 1. However, for the number operator, N, and the N-Hamiltonian for a free q-boson gas, H(sub N) = h(omega)(N + 1/2), the fractional uncertainties do still approach zero. A signature for q-boson counting statistics is that (Delta N)(exp 2)/ (N) approaches 0 as the absolute value of z approaches infinity. Except for its O(1) fractional uncertainty, the q-generalization of the Hermitian phase operator of Pegg and Barnett, phi(sub q), still exhibits normal classical behavior. The standard number-phase uncertainty-relation, Delta(N) Delta phi(sub q) = 1/2, and the approximate commutation relation, (N, phi(sub q)) = i, still hold for the single-mode q-analogue quantized field. So, N and phi(sub q) are almost canonically conjugate operators in the q-CS classical limit. The q-analogue CS's minimize this uncertainty relation for moderate (absolute value of z)(exp 2).

The Process and Effects of Mass Communication. Revised Edition.

ERIC Educational Resources Information Center

Schramm, Wilbur, Ed.; Roberts, Donald F., Ed.

Composed of a mixture of old classics, new classics, reports on state of the art in important areas, and speculations about the future, this second edition of the reader in communication research provides an introduction to questions about how communication works and what it does. Papers by prominent researchers and writers in the field comprise…

Using Classical Reliability Models and Single Event Upset (SEU) Data to Determine Optimum Implementation Schemes for Triple Modular Redundancy (TMR) in SRAM-Based Field Programmable Gate Array (FPGA) Devices

NASA Technical Reports Server (NTRS)

Berg, M.; Kim, H.; Phan, A.; Seidleck, C.; LaBel, K.; Pellish, J.; Campola, M.

2015-01-01

Space applications are complex systems that require intricate trade analyses for optimum implementations. We focus on a subset of the trade process, using classical reliability theory and SEU data, to illustrate appropriate TMR scheme selection.

Chaotic electron transport in semiconductor devices

NASA Astrophysics Data System (ADS)

Scannell, William Christian

The field of quantum chaos investigates the quantum mechanical behavior of classically chaotic systems. This dissertation begins by describing an experiment conducted on an apparatus constructed to represent a three dimensional analog of a classically chaotic system. Patterns of reflected light are shown to produce fractals, and the behavior of the fractal dimension D F is shown to depend on the light's ability to escape the apparatus. The classically chaotic system is then used to investigate the conductance properties of semiconductor heterostructures engineered to produce a conducting plane relatively free of impurities and defects. Introducing walls that inhibit conduction to partition off sections considerably smaller than the mean distance between impurities defines devices called 'billiards'. Cooling to low temperatures enables the electrons traveling through the billiard to maintain quantum mechanical phase. Exposure to a changing electric or magnetic field alters the electron's phase, leading to fluctuations in the conductance through the billiard. Magnetoconductance fluctuations in billiards have previously been shown to be fractal. This behavior has been charted using an empirical parameter, Q, that is a measure of the resolution of the energy levels within the billiard. The relationship with Q is shown to extend beyond the ballistic regime into the 'quasi-ballistic' and 'diffusive' regimes, characterized by having defects within the conduction plane. A model analogous to the classically chaotic system is proposed as the origin of the fractal conductance fluctuations. This model is shown to be consistent with experiment and to account for changes of fine scale features in MCF known to occur when a billiard is brought to room temperature between low temperature measurements. An experiment is conducted in which fractal conductance fluctuations (FCF) are produced by exposing a billiard to a changing electric field. Comparison of DF values of FCF produced by electric fields is made to FCF produced by magnetic fields. FCF with high DF values are shown to de-correlate at smaller increments of field than the FCF with lower DF values. This indicates that FCF may be used as a novel sensor of external fields, so the response of FCF to high bias voltages is investigated.

Classical impurity ion confinement in a toroidal magnetized fusion plasma.

PubMed

Kumar, S T A; Den Hartog, D J; Caspary, K J; Magee, R M; Mirnov, V V; Chapman, B E; Craig, D; Fiksel, G; Sarff, J S

2012-03-23

High-resolution measurements of impurity ion dynamics provide first-time evidence of classical ion confinement in a toroidal, magnetically confined plasma. The density profile evolution of fully stripped carbon is measured in MST reversed-field pinch plasmas with reduced magnetic turbulence to assess Coulomb-collisional transport without the neoclassical enhancement from particle drift effects. The impurity density profile evolves to a hollow shape, consistent with the temperature screening mechanism of classical transport. Corroborating methane pellet injection experiments expose the sensitivity of the impurity particle confinement time to the residual magnetic fluctuation amplitude.

Non-linear quantum-classical scheme to simulate non-equilibrium strongly correlated fermionic many-body dynamics

PubMed Central

Kreula, J. M.; Clark, S. R.; Jaksch, D.

2016-01-01

We propose a non-linear, hybrid quantum-classical scheme for simulating non-equilibrium dynamics of strongly correlated fermions described by the Hubbard model in a Bethe lattice in the thermodynamic limit. Our scheme implements non-equilibrium dynamical mean field theory (DMFT) and uses a digital quantum simulator to solve a quantum impurity problem whose parameters are iterated to self-consistency via a classically computed feedback loop where quantum gate errors can be partly accounted for. We analyse the performance of the scheme in an example case. PMID:27609673

Lattice constants of pure methane and carbon dioxide hydrates at low temperatures. Implementing quantum corrections to classical molecular dynamics studies

DOE Office of Scientific and Technical Information (OSTI.GOV)

Costandy, Joseph; Michalis, Vasileios K.; Economou, Ioannis G., E-mail: i.tsimpanogiannis@qatar.tamu.edu, E-mail: ioannis.economou@qatar.tamu.edu

2016-03-28

We introduce a simple correction to the calculation of the lattice constants of fully occupied structure sI methane or carbon dioxide pure hydrates that are obtained from classical molecular dynamics simulations using the TIP4PQ/2005 water force field. The obtained corrected lattice constants are subsequently used in order to obtain isobaric thermal expansion coefficients of the pure gas hydrates that exhibit a trend that is significantly closer to the experimental behavior than previously reported classical molecular dynamics studies.

Synchronization modulation of Na/K pumps on Xenopus oocytes

NASA Astrophysics Data System (ADS)

Liang, Pengfei; Mast, Jason; Chen, Wei

We developed a new technique named synchronization modulation to electrically synchronize and modulate the Na/K pump molecules by a specially designed oscillating electric field. This technique is based on the theory of energy-trap in quantum physics as well as the concept of electronic synchrotron accelerator. As a result, the Na-transports are all entrapped into the positive half-cycle of the applied electric field and consequently, all of the K-transports are entrapped into the negative half cycle of the field. To demonstrate the process of the pump synchronization and modulation, we use Xenopus oocytes as a platform and introduce two-electrode whole-cell voltage clamp in measurement of pump current. Practically, we first synchronize the pump molecules running at the same pace (rate and phase) by a specially designed oscillation electric field. Then, we carefully maintain the pump synchronization status and gradually change the field frequency (decrease and increase) to modulate the pump molecules to newer pumping rate. The result shows a separation of the inward K current from the outward Na current, and about 10 time increase of the total (inward plus outward) pump current from the net outward current from the random paced pump molecules. Also, the ratio of the modulated total pump current with synchronized total pump current is consistent with the ratio of their field frequencies.

Field Testing Vocational Education Metric Modules. Final Report.

ERIC Educational Resources Information Center

Oldsen, Carl F.

A project was conducted for the following purposes: (1) to develop a workshop training package to prepare vocational education teachers to use vocational subject-specific modules; (2) to train those teachers to use the workshop package; (3) to conduct field tests of the metric modules with experimental and control groups; (4) to analyze, describe,…

Radio-frequency-modulated Rydberg states in a vapor cell

NASA Astrophysics Data System (ADS)

Miller, S. A.; Anderson, D. A.; Raithel, G.

2016-05-01

We measure strong radio-frequency (RF) electric fields using rubidium Rydberg atoms prepared in a room-temperature vapor cell as field sensors. Electromagnetically induced transparency is employed as an optical readout. We RF-modulate the 60{{{S}}}1/2 and 58{{{D}}}5/2 Rydberg states with 50 and 100 MHz fields, respectively. For weak to moderate RF fields, the Rydberg levels become Stark-shifted, and sidebands appear at even multiples of the driving frequency. In high fields, the adjacent hydrogenic manifold begins to intersect the shifted levels, providing rich spectroscopic structure suitable for precision field measurements. A quantitative description of strong-field level modulation and mixing of S and D states with hydrogenic states is provided by Floquet theory. Additionally, we estimate the shielding of DC electric fields in the interior of the glass vapor cell.

[Biofabrication: new approaches for tissue regeneration].

PubMed

Horch, Raymund E; Weigand, Annika; Wajant, Harald; Groll, Jürgen; Boccaccini, Aldo R; Arkudas, Andreas

2018-04-01

The advent of Tissue Engineering (TE) in the early 1990ies was fostered by the increasing need for functional tissue and organ replacement. Classical TE was based on the combination of carrier matrices, cells and growth factors to reconstitute lost or damaged tissue and organs. Despite considerable results in vitro and in experimental settings the lack of early vascularization has hampered its translation into daily clinical practice so far. A new field of research, called "biofabrication" utilizing latest 3D printing technologies aims at hierarchically and spatially incorporating different cells, biomaterials and molecules into a matrix to alleviate a directed maturation of artificial tissue. A literature research of the relevant publications regarding biofabrication and bioprinting was performed using the PubMed data base. Relevant papers were selected and evaluated with secondary analysis of specific citations on the bioprinting techniques. 180 relevant papers containing the key words were identified and evaluated. Basic principles into the developing field of bioprinting technology could be discerned. Key elements comprise the high-throughput assembly of cells and the fabrication of complex and functional hierarchically organized tissue constructs. Five relevant technological principles for bioprinting were identified, such as stereolithography, extrusion-based printing, laser-assisted printing, inkjet-based printing and nano-bioprinting. The different technical methods of 3D printing were found to be associated with various positive but also negative effects on cells and proteins during the printing process. Research efforts in this field obviously aim towards the development of optimizing the so called bioinks and the printing technologies. This review details the evolution of the classical methods of TE in Regenerative Medicine into the evolving field of biofabrication by bioprinting. The advantages of 3D bioprinting over traditional tissue engineering techniques are based on the assembling of cells, biomaterials and biomolecules in a spatially controlled manner to reproduce native tissue macro-, micro- and nanoarchitectures, that can be utilized not only to potentially produce functional replacement tissues or organs but also to serve as new models for basic research. Mimicking the stromal microenvironment of tumor cells to study the process of tumor formation and progression, metastasis, angiogenesis and modulation of the associated processes is one of these applications under research. To this end a close collaboration of specialists from the fields of engineering, biomaterial science, cell biology and reconstructive microsurgery will be necessary to develop future strategies that can overcome current limitations of tissue generation. © Georg Thieme Verlag KG Stuttgart · New York.

Emerging Nanophotonic Applications Explored with Advanced Scientific Parallel Computing

NASA Astrophysics Data System (ADS)

Meng, Xiang

The domain of nanoscale optical science and technology is a combination of the classical world of electromagnetics and the quantum mechanical regime of atoms and molecules. Recent advancements in fabrication technology allows the optical structures to be scaled down to nanoscale size or even to the atomic level, which are far smaller than the wavelength they are designed for. These nanostructures can have unique, controllable, and tunable optical properties and their interactions with quantum materials can have important near-field and far-field optical response. Undoubtedly, these optical properties can have many important applications, ranging from the efficient and tunable light sources, detectors, filters, modulators, high-speed all-optical switches; to the next-generation classical and quantum computation, and biophotonic medical sensors. This emerging research of nanoscience, known as nanophotonics, is a highly interdisciplinary field requiring expertise in materials science, physics, electrical engineering, and scientific computing, modeling and simulation. It has also become an important research field for investigating the science and engineering of light-matter interactions that take place on wavelength and subwavelength scales where the nature of the nanostructured matter controls the interactions. In addition, the fast advancements in the computing capabilities, such as parallel computing, also become as a critical element for investigating advanced nanophotonic devices. This role has taken on even greater urgency with the scale-down of device dimensions, and the design for these devices require extensive memory and extremely long core hours. Thus distributed computing platforms associated with parallel computing are required for faster designs processes. Scientific parallel computing constructs mathematical models and quantitative analysis techniques, and uses the computing machines to analyze and solve otherwise intractable scientific challenges. In particular, parallel computing are forms of computation operating on the principle that large problems can often be divided into smaller ones, which are then solved concurrently. In this dissertation, we report a series of new nanophotonic developments using the advanced parallel computing techniques. The applications include the structure optimizations at the nanoscale to control both the electromagnetic response of materials, and to manipulate nanoscale structures for enhanced field concentration, which enable breakthroughs in imaging, sensing systems (chapter 3 and 4) and improve the spatial-temporal resolutions of spectroscopies (chapter 5). We also report the investigations on the confinement study of optical-matter interactions at the quantum mechanical regime, where the size-dependent novel properties enhanced a wide range of technologies from the tunable and efficient light sources, detectors, to other nanophotonic elements with enhanced functionality (chapter 6 and 7).

Wide-field imaging through scattering media by scattered light fluorescence microscopy

NASA Astrophysics Data System (ADS)

Zhou, Yulan; Li, Xun

2017-08-01

To obtain images through scattering media, scattered light fluorescence (SLF) microscopy that utilizes the optical memory effect has been developed. However, the small field of view (FOV) of SLF microscopy limits its application. In this paper, we have introduced a re-modulation method to achieve wide-field imaging through scattering media by SLF microscopy. In the re-modulation method, to raster scan the focus across the object plane, the incident wavefront is re-modulated via a spatial light modulator (SLM) in the updated phase compensation calculated using the optimized iterative algorithm. Compared with the conventional optical memory effect method, the re-modulation method can greatly increase the FOV of a SLF microscope. With the phase compensation theoretically calculated, the process of updating the phase compensation of a high speed SLM is fast. The re-modulation method does not increase the imaging time. The re-modulation method is, therefore, expected to make SLF microscopy have much wider applications in biology, medicine and physiology.

Matter and Interactions: A Particle Physics Perspective

ERIC Educational Resources Information Center

Organtini, Giovanni

2011-01-01

In classical mechanics, matter and fields are completely separated; matter interacts with fields. For particle physicists this is not the case; both matter and fields are represented by particles. Fundamental interactions are mediated by particles exchanged between matter particles. In this article we explain why particle physicists believe in…

A Study of Two Instructional Sequences Informed by Alternative Learning Progressions in Genetics

NASA Astrophysics Data System (ADS)

Duncan, Ravit Golan; Choi, Jinnie; Castro-Faix, Moraima; Cavera, Veronica L.

2017-12-01

Learning progressions (LPs) are hypothetical models of how learning in a domain develops over time with appropriate instruction. In the domain of genetics, there are two independently developed alternative LPs. The main difference between the two progressions hinges on their assumptions regarding the accessibility of classical (Mendelian) versus molecular genetics and the order in which they should be taught. In order to determine the relative difficulty of the different genetic ideas included in the two progressions, and to test which one is a better fit with students' actual learning, we developed two modules in classical and molecular genetics and alternated their sequence in an implementation study with 11th grade students studying biology. We developed a set of 56 ordered multiple-choice items that collectively assessed both molecular and classical genetic ideas. We found significant gains in students' learning in both molecular and classical genetics, with the largest gain relating to understanding the informational content of genes and the smallest gain in understanding modes of inheritance. Using multidimensional item response modeling, we found no statistically significant differences between the two instructional sequences. However, there was a trend of slightly higher gains for the molecular-first sequence for all genetic ideas.

The European DISABKIDS project: development of seven condition-specific modules to measure health related quality of life in children and adolescents

PubMed Central

Baars, Rolanda M; Atherton, Clare I; Koopman, Hendrik M; Bullinger, Monika; Power, Mick

2005-01-01

Background The European DISABKIDS project aims to enhance the Health Related Quality of Life (HRQoL) of children and adolescents with chronic medical conditions and their families. We describe the development of the seven cross-nationally tested condition-specific modules of the European DISABKIDS HRQoL instrument in a population of children and adolescents. The condition-specific modules are intended for use in conjunction with the DISABKIDS chronic generic module. Methods Focus groups were used to construct the pilot version of the DISABKIDS condition-specific HRQoL modules for asthma, juvenile idiopathic arthritis, atopic dermatitis, cerebral palsy, cystic fibrosis, diabetes and epilepsy. Analyses were conducted on pilot test data in order to construct field test versions of the modules. A series of factor analyses were run, first, to determine potential structures for each condition-specific module, and, secondly, to select a reduced number of items from the pilot test to be included in the field test. Post-field test analyses were conducted to retest the domain structure for the final DISABKIDS condition-specific modules. Results The DISABKIDS condition-specific modules were tested in a pilot study of 360 respondents, and subsequently in a field test of 1152 respondents in 7 European countries. The final condition-specific modules consist of an 'Impact' domain and an additional domain (e.g. worry, stigma, treatment) with between 10 to 12 items in total. The Cronbach's alpha of the final domains was found to vary from 0.71 to 0.90. Conclusion The condition-specific modules of the DISABKIDS instrument were developed through a step-by-step process including cognitive interview, clinical expertise, factor analysis, correlations and internal consistency. A cross-national pilot and field test were necessary to collect these data. In general, the internal consistency of the domains was satisfactory to high. In future, the DISABKIDS instrument may serve as a useful tool with which to assess HRQoL in children and adolescents with a chronic condition. The condition-specific modules can be used in conjunction with the DISABKIDS chronic generic module. PMID:16283947

The European DISABKIDS project: development of seven condition-specific modules to measure health related quality of life in children and adolescents.

PubMed

Baars, Rolanda M; Atherton, Clare I; Koopman, Hendrik M; Bullinger, Monika; Power, Mick

2005-11-13

The European DISABKIDS project aims to enhance the Health Related Quality of Life (HRQoL) of children and adolescents with chronic medical conditions and their families. We describe the development of the seven cross-nationally tested condition-specific modules of the European DISABKIDS HRQoL instrument in a population of children and adolescents. The condition-specific modules are intended for use in conjunction with the DISABKIDS chronic generic module. Focus groups were used to construct the pilot version of the DISABKIDS condition-specific HRQoL modules for asthma, juvenile idiopathic arthritis, atopic dermatitis, cerebral palsy, cystic fibrosis, diabetes and epilepsy. Analyses were conducted on pilot test data in order to construct field test versions of the modules. A series of factor analyses were run, first, to determine potential structures for each condition-specific module, and, secondly, to select a reduced number of items from the pilot test to be included in the field test. Post-field test analyses were conducted to retest the domain structure for the final DISABKIDS condition-specific modules. The DISABKIDS condition-specific modules were tested in a pilot study of 360 respondents, and subsequently in a field test of 1152 respondents in 7 European countries. The final condition-specific modules consist of an 'Impact' domain and an additional domain (e.g. worry, stigma, treatment) with between 10 to 12 items in total. The Cronbach's alpha of the final domains was found to vary from 0.71 to 0.90. The condition-specific modules of the DISABKIDS instrument were developed through a step-by-step process including cognitive interview, clinical expertise, factor analysis, correlations and internal consistency. A cross-national pilot and field test were necessary to collect these data. In general, the internal consistency of the domains was satisfactory to high. In future, the DISABKIDS instrument may serve as a useful tool with which to assess HRQoL in children and adolescents with a chronic condition. The condition-specific modules can be used in conjunction with the DISABKIDS chronic generic module.

Modulation of local field potential power of the subthalamic nucleus during isometric force generation in patients with Parkinson's disease.

PubMed

Florin, E; Dafsari, H S; Reck, C; Barbe, M T; Pauls, K A M; Maarouf, M; Sturm, V; Fink, G R; Timmermann, L

2013-06-14

Investigations of local field potentials of the subthalamic nucleus of patients with Parkinson's disease have provided evidence for pathologically exaggerated oscillatory beta-band activity (13-30 Hz) which is amenable to physiological modulation by, e.g., voluntary movement. Previous functional magnetic resonance imaging studies in healthy controls have provided evidence for an increase of subthalamic nucleus blood-oxygenation-level-dependant signal in incremental force generation tasks. However, the modulation of neuronal activity by force generation and its relationship to peripheral feedback remain to be elucidated. We hypothesised that beta-band activity in the subthalamic nucleus is modulated by incremental force generation. Subthalamic nucleus local field potentials were recorded intraoperatively in 13 patients with Parkinson's disease (37 recording sites) during rest and five incremental isometric force generation conditions of the arm with applied loads of 0-400 g (in 100-g increments). Repeated measures analysis of variance (ANOVA) revealed a modulation of local field potential (LFP) power in the upper beta-band (in 24-30 Hz; F(₃.₀₄₂)=4.693, p=0.036) and the gamma-band (in 70-76 Hz; F(₄)=4.116, p=0.036). Granger-causality was computed with the squared partial directed coherence and showed no significant modulation during incremental isometric force generation. Our findings indicate that the upper beta- and gamma-band power of subthalamic nucleus local field potentials are modulated by the physiological task of force generation in patients with Parkinson's disease. This modulation seems to be not an effect of a modulation of peripheral feedback. Copyright © 2013 IBRO. Published by Elsevier Ltd. All rights reserved.

Dielectric elastomer peristaltic pump module with finite deformation

NASA Astrophysics Data System (ADS)

Mao, Guoyong; Huang, Xiaoqiang; Liu, Junjie; Li, Tiefeng; Qu, Shaoxing; Yang, Wei

2015-07-01

Inspired by various peristaltic structures existing in nature, several bionic peristaltic actuators have been developed. In this study, we propose a novel dielectric elastomer peristaltic pump consisting of short tubular modules, with the saline solution as the electrodes. We investigate the performance of this soft pump module under hydraulic pressure and voltage via experiments and an analytical model based on nonlinear field theory. It is observed that the individual pump module undergoes finite deformation and may experience electromechanical instability during operations. The driving pressure and displaced volume of the peristaltic pump module can be modulated by applied voltage. The efficiency of the pump module is enhanced by alternating current voltage, which can suppress the electromechanical pull-in instability. An analytical model is developed within the framework of the nonlinear field theory, and its predictive capacity is checked by experimental observations. The effects of the prestretch, aspect ratio, and voltage on the performance of the pump modules are characterized by the analytical model. This work can guide the designs of soft active peristaltic pumps in the field of artificial organs and industrial conveying systems.

BoreholeAR: A mobile tablet application for effective borehole database visualization using an augmented reality technology

NASA Astrophysics Data System (ADS)

Lee, Sangho; Suh, Jangwon; Park, Hyeong-Dong

2015-03-01

Boring logs are widely used in geological field studies since the data describes various attributes of underground and surface environments. However, it is difficult to manage multiple boring logs in the field as the conventional management and visualization methods are not suitable for integrating and combining large data sets. We developed an iPad application to enable its user to search the boring log rapidly and visualize them using the augmented reality (AR) technique. For the development of the application, a standard borehole database appropriate for a mobile-based borehole database management system was designed. The application consists of three modules: an AR module, a map module, and a database module. The AR module superimposes borehole data on camera imagery as viewed by the user and provides intuitive visualization of borehole locations. The map module shows the locations of corresponding borehole data on a 2D map with additional map layers. The database module provides data management functions for large borehole databases for other modules. Field survey was also carried out using more than 100,000 borehole data.

On gravity's role in the genesis of rest masses of classical fields

NASA Astrophysics Data System (ADS)

Szabados, László B.

2018-03-01

It is shown that in the Einstein-conformally coupled Higgs-Maxwell system with Friedman-Robertson-Walker symmetries the energy density of the Higgs field has stable local minimum only if the mean curvature of the t=const hypersurfaces is less than a finite critical value χ _c, while for greater mean curvature the energy density is not bounded from below. Therefore, there are extreme gravitational situations in which even quasi-locally defined instantaneous vacuum states of the Higgs sector cannot exist, and hence one cannot at all define the rest mass of all the classical fields. On hypersurfaces with mean curvature less than χ _c the energy density has the `wine bottle' (rather than the familiar `Mexican hat') shape, and the gauge field can get rest mass via the Brout-Englert-Higgs mechanism. The spacelike hypersurface with the critical mean curvature represents the moment of `genesis' of rest masses.

On classical mechanical systems with non-linear constraints

NASA Astrophysics Data System (ADS)

Terra, Gláucio; Kobayashi, Marcelo H.

2004-03-01

In the present work, we analyze classical mechanical systems with non-linear constraints in the velocities. We prove that the d'Alembert-Chetaev trajectories of a constrained mechanical system satisfy both Gauss' principle of least constraint and Hölder's principle. In the case of a free mechanics, they also satisfy Hertz's principle of least curvature if the constraint manifold is a cone. We show that the Gibbs-Maggi-Appell (GMA) vector field (i.e. the second-order vector field which defines the d'Alembert-Chetaev trajectories) conserves energy for any potential energy if, and only if, the constraint is homogeneous (i.e. if the Liouville vector field is tangent to the constraint manifold). We introduce the Jacobi-Carathéodory metric tensor and prove Jacobi-Carathéodory's theorem assuming that the constraint manifold is a cone. Finally, we present a version of Liouville's theorem on the conservation of volume for the flow of the GMA vector field.

Experimental Bell violations with classical, non-entangled optical fields

NASA Astrophysics Data System (ADS)

Gonzales, J.; Sánchez, P.; Barberena, D.; Yugra, Y.; Caballero, R.; De Zela, F.

2018-02-01

We report experiments in which the Bell parameter S that enters the Clauser-Horne-Shimony-Holt inequality: | S| ≤slant 2, attains values | S| > 2. In our experiments, we used two spatially separated optical beams, the electric fields of which were correlated to one another. The amount of correlation was quantified by the spectral degree of coherence η (α ,β ). This quantity measures the correlation between fields that exist at two distant locations and whose respective polarizations are given in terms of angles α and β, which can be set independently from one another. Such a correlation qualifies for the construction of the Bell parameter S. By changing the amount of field correlation, we could cover a range that goes from | S| < 2 to | S| > 2. Our experimental findings should provide useful material for the ongoing, theoretical discussions about the quantum-classical border.

On the structure of quantum L∞ algebras

NASA Astrophysics Data System (ADS)

Blumenhagen, Ralph; Fuchs, Michael; Traube, Matthias

2017-10-01

It is believed that any classical gauge symmetry gives rise to an L∞ algebra. Based on the recently realized relation between classical W algebras and L∞ algebras, we analyze how this generalizes to the quantum case. Guided by the existence of quantum W algebras, we provide a physically well motivated definition of quantum L∞ algebras describing the consistency of global symmetries in quantum field theories. In this case we are restricted to only two non-trivial graded vector spaces X 0 and X -1 containing the symmetry variations and the symmetry generators. This quantum L∞ algebra structure is explicitly exemplified for the quantum W_3 algebra. The natural quantum product between fields is the normal ordered one so that, due to contractions between quantum fields, the higher L∞ relations receive off-diagonal quantum corrections. Curiously, these are not present in the loop L∞ algebra of closed string field theory.

Low-temperature structural and transport anomalies in Cu2Se

NASA Astrophysics Data System (ADS)

Chi, Hang; Kim, Hyoungchul; Thomas, John C.; Shi, Guangsha; Sun, Kai; Abeykoon, Milinda; Bozin, Emil S.; Shi, Xiaoya; Li, Qiang; Shi, Xun; Kioupakis, Emmanouil; Van der Ven, Anton; Kaviany, Massoud; Uher, Ctirad

2014-05-01

Through systematic examination of symmetrically nonequivalent configurations, first-principles calculations have identified a new ground state of Cu2Se, which is constructed by repeating sextuple layers of Se-Cu-Cu-Cu-Cu-Se. The layered nature is in accord with electron and x-ray diffraction studies at and below room temperature and also is consistent with transport properties. Magnetoresistance measurements at liquid helium temperatures exhibit cusp-shaped field dependence at low fields and evolve into quasilinear field dependence at intermediate and high fields. These results reveal the existence of weak antilocalization effect, which has been analyzed using a modified Hikami, Larkin, and Nagaoka model, including a quantum interference term and a classical quadratic contribution. Fitting parameters suggest a quantum coherence length L of 175 nm at 1.8 K. With increasing temperature, the classical parabolic behavior becomes more dominant, and L decreases as a power law of T-0.83.

Plasmon mass scale in two-dimensional classical nonequilibrium gauge theory

NASA Astrophysics Data System (ADS)

Lappi, T.; Peuron, J.

2018-02-01

We study the plasmon mass scale in classical gluodynamics in a two-dimensional configuration that mimics the boost-invariant initial color fields in a heavy-ion collision. We numerically measure the plasmon mass scale using three different methods: a hard thermal loop (HTL) expression involving the quasiparticle spectrum constructed from Coulomb gauge field correlators, an effective dispersion relation, and the measurement of oscillations between electric and magnetic energies after introducing a spatially uniform perturbation to the electric field. We find that the HTL expression and the uniform electric field measurement are in rough agreement. The effective dispersion relation agrees with other methods within a factor of 2. We also study the dependence on time and occupation number, observing similar trends as in three spatial dimensions, where a power-law dependence sets in after an occupation-number-dependent transient time. We observe a decrease of the plasmon mass squared as t-1 / 3 at late times.

Microfluidics on liquid handling stations (μF-on-LHS): a new industry-compatible microfluidic platform

NASA Astrophysics Data System (ADS)

Kittelmann, Jörg; Radtke, Carsten P.; Waldbaur, Ansgar; Neumann, Christiane; Hubbuch, Jürgen; Rapp, Bastian E.

2014-03-01

Since the early days microfluidics as a scientific discipline has been an interdisciplinary research field with a wide scope of potential applications. Besides tailored assays for point-of-care (PoC) diagnostics, microfluidics has been an important tool for large-scale screening of reagents and building blocks in organic chemistry, pharmaceutics and medical engineering. Furthermore, numerous potential marketable products have been described over the years. However, especially in industrial applications, microfluidics is often considered only an alternative technology for fluid handling, a field which is industrially mostly dominated by large-scale numerically controlled fluid and liquid handling stations. Numerous noteworthy products have dominated this field in the last decade and have been inhibited the widespread application of microfluidics technology. However, automated liquid handling stations and microfluidics do not have to be considered as mutually exclusive approached. We have recently introduced a hybrid fluidic platform combining an industrially established liquid handling station and a generic microfluidic interfacing module that allows probing a microfluidic system (such as an essay or a synthesis array) using the instrumentation provided by the liquid handling station. We term this technology "Microfluidic on Liquid Handling Stations (μF-on-LHS)" - a classical "best of both worlds"- approach that allows combining the highly evolved, automated and industry-proven LHS systems with any type of microfluidic assay. In this paper we show, to the best of our knowledge, the first droplet microfluidics application on an industrial LHS using the μF-on-LHS concept.

Using the Firefly optimization method to weight an ensemble of rainfall forecasts from the Brazilian developments on the Regional Atmospheric Modeling System (BRAMS)

NASA Astrophysics Data System (ADS)

dos Santos, A. F.; Freitas, S. R.; de Mattos, J. G. Z.; de Campos Velho, H. F.; Gan, M. A.; da Luz, E. F. P.; Grell, G. A.

2013-09-01

In this paper we consider an optimization problem applying the metaheuristic Firefly algorithm (FY) to weight an ensemble of rainfall forecasts from daily precipitation simulations with the Brazilian developments on the Regional Atmospheric Modeling System (BRAMS) over South America during January 2006. The method is addressed as a parameter estimation problem to weight the ensemble of precipitation forecasts carried out using different options of the convective parameterization scheme. Ensemble simulations were performed using different choices of closures, representing different formulations of dynamic control (the modulation of convection by the environment) in a deep convection scheme. The optimization problem is solved as an inverse problem of parameter estimation. The application and validation of the methodology is carried out using daily precipitation fields, defined over South America and obtained by merging remote sensing estimations with rain gauge observations. The quadratic difference between the model and observed data was used as the objective function to determine the best combination of the ensemble members to reproduce the observations. To reduce the model rainfall biases, the set of weights determined by the algorithm is used to weight members of an ensemble of model simulations in order to compute a new precipitation field that represents the observed precipitation as closely as possible. The validation of the methodology is carried out using classical statistical scores. The algorithm has produced the best combination of the weights, resulting in a new precipitation field closest to the observations.

Modulated near-field spectral extraction of broadband mid-infrared signals with a ceramic light source.

PubMed

Ishikawa, Michio; Katsura, Makoto; Nakashima, Satoru; Aizawa, Kento; Inoue, Tsutomu; Okamura, Hidekazu; Ikemoto, Yuka

2011-06-20

In order to obtain broadband near-field infrared (IR) spectra, a Fourier-transform IR spectrometer (FT-IR) and a ceramic light source were used with a scattering-type scanning near-field optical microscope (s-SNOM). To suppress the background (far-field) scattering, the distance between the scattering probe and the sample was modulated with frequency Ω by a piezo-electric actuator, and the Ω component was extracted from the signal with a lock-in detection. With Ω=30 kHz, a peak-to-peak modulation amplitude of 198 nm, and a probe with smooth surface near the tip, broadband near-field IR spectra could be obtained in the 1200-2500 cm(-1).

A Field Artillery Module for the Airland Research Model.

DTIC Science & Technology

1986-03-01

8217-"" ET 524 LEVEL REPRESENTED IN THE TABLE -INIAN SHOULD CORRESPOND TO THE LEVEL OF .IMNANOH RESOLUTION IN THE MODEL -I-HOWITZERS HOWITZERS AMMUNITION Al ...AD-A168 388 A FIELD ARTILLERY MODULE FOR THE AIRLAMD RESEARCH MODEL i (U) NAVAL POSTGRADURTE SCHOOL MONTEREY CA L M FINLEY 4 UNCLASSIFIED F/G 1712 NL...A FIELD ARTILLERY MODULE FOR THE AIRLAND RESEARCH MODEL by Leonard M. Finley CD - C.- March 1986 Thesis Advisor: S. H. Parry Approved for public

Adult mouse motor units develop almost all of their force in the subprimary range: a new all-or-none strategy for force recruitment?

PubMed

Manuel, Marin; Heckman, C J

2011-10-19

Classical studies of the mammalian neuromuscular system have shown an impressive adaptation match between the intrinsic properties of motoneurons and the contractile properties of their motor units. In these studies, the rate at which motoneurons start to fire repetitively corresponds to the rate at which individual twitches start to sum, and the firing rate increases linearly with the amount of excitation ("primary range") up to the point where the motor unit develops its maximal force. This allows for the gradation of the force produced by a motor unit by rate modulation. In adult mouse motoneurons, however, we recently described a regime of firing ("subprimary range") that appears at lower excitation than what is required for the primary range, a finding that might challenge the classical conception. To investigate the force production of mouse motor units, we simultaneously recorded, for the first time, the motoneuron discharge elicited by intracellular ramps of current and the force developed by its motor unit. We showed that the motor unit developed nearly its maximal force during the subprimary range. This was found to be the case regardless of the input resistance of the motoneuron, the contraction speed, or the tetanic force of the motor unit. Our work suggests that force modulation in small mammals mainly relies on the number of motor units that are recruited rather than on rate modulation of individual motor units.

Prominence of scientific publications towards peri-implant complications in implantology: A bibliometric analysis using the H-classics method.

PubMed

Chiang, H-S; Huang, R-Y; Weng, P-W; Mau, L-P; Tsai, Y-W C; Chung, M-P; Chung, C-H; Yeh, H-W; Shieh, Y-S; Cheng, W-C

2018-03-01

Current bibliometric analyses of the evolving trends in research scope category across different time periods using the H-classics method in implantology are considerably limited. The purpose of this study was to identify the classic articles in implantology to analyse bibliometric characteristics and associated factors in implantology for the past four decades. H-Classics in implantology were identified within four time periods between 1977 and 2016, based on the h-index from the Scopus ® database. For each article, the principal bibliometric parameters of authorship, geographic origin, country origin, and institute origin, collaboration, centralisation, article type, scope of study and other associated factors were analysed in four time periods. A significant increase in mean numbers of authors per H-Classics was found across time. Both Europe and North America were the most productive region/country and steadily dominated this field in each time period. Collaborations of author, internationally and inter-institutionally had significantly increased across time. A significant decentralisation in authorships, institutes and journals was noted in past four decades. The journal of Clinical Oral Implant Researches has raised its importance for almost 30 years (1987-2016). Research on Complications, peri-implant infection/pathology/therapy had been increasing in production throughout each period. This is the first study to evaluate research trends in implantology in the past 40 years using the H-classics method, which through analysing via principle bibliometric characteristics reflected a historical perspective on evolutionary mainstream in the field. Prominence of research regarding complications may forecast innovative advancements in future. © 2018 John Wiley & Sons Ltd.

Non-classical nuclei and growth kinetics of Cr precipitates in FeCr alloys during ageing

DOE Office of Scientific and Technical Information (OSTI.GOV)

Li, Yulan; Hu, Shenyang Y.; Zhang, Lei

2014-01-10

In this manuscript, we quantitatively calculated the thermodynamic properties of critical nuclei of Cr precipitates in FeCr alloys. The concentration profiles of the critical nuclei and nucleation energy barriers were predicted by the constrained shrinking dimer dynamics (CSDD) method. It is found that Cr concentration distribution in the critical nuclei strongly depend on the overall Cr concentration as well as temperature. The critical nuclei are non-classical because the concentration in the nuclei is smaller than the thermodynamic equilibrium value. These results are in agreement with atomic probe observation. The growth kinetics of both classical and non-classical nuclei was investigated bymore » the phase field approach. The simulations of critical nucleus evolution showed a number of interesting phenomena: 1) a critical classical nucleus first shrinks toward its non-classical nucleus and then grows; 2) a non-classical nucleus has much slower growth kinetics at its earlier growth stage compared to the diffusion-controlled growth kinetics. 3) a critical classical nucleus grows faster at the earlier growth stage than the non-classical nucleus. All of these results demonstrate that it is critical to introduce the correct critical nuclei in order to correctly capture the kinetics of precipitation.« less