Sample records for click libraries proceedings

  1. Brick & Click Libraries: An Academic Library Conference Proceedings (16th, Maryville, Missouri, November 4, 2016)

    ERIC Educational Resources Information Center

    Baudino, Frank, Ed.; Johnson, Carolyn, Ed.

    2016-01-01

    Twenty scholarly papers and fifteen abstracts comprise the content of the sixteenth annual Brick and Click Libraries Conference, held annually at Northwest Missouri State University in Maryville, Missouri. The proceedings, authored by academic librarians and presented at the symposium, portray the contemporary and future face of librarianship. The…

  2. Brick and Click Libraries: Proceedings of an Academic Libraries Symposium (7th, Maryville, Missouri, November 2, 2007)

    ERIC Educational Resources Information Center

    Ury, Connie Jo, Ed.; Baudino, Frank, Ed.; Park, Sarah G., Ed.

    2007-01-01

    Twenty-three scholarly papers and eleven abstracts reflect the content of the seventh "Brick and Click Libraries Symposium," held annually at Northwest Missouri State University in Maryville, Missouri. The proceedings, authored by academic librarians and presented at the symposium, portray the contemporary and future face of…

  3. Brick and Click Libraries: Proceedings of an Academic Library Symposium (11th, Maryville, Missouri, November 4, 2011)

    ERIC Educational Resources Information Center

    Baudino, Frank, Ed.

    2011-01-01

    Twenty-three scholarly papers and twelve abstracts comprise the content of the eleventh annual Brick and Click Libraries Symposium, held at Northwest Missouri State University in Maryville, Missouri. The peer-reviewed proceedings, authored by academic librarians and presented at the symposium, portray the contemporary and future face of…

  4. Brick and Click Libraries: Proceedings of an Academic Library Symposium (10th, Maryville, Missouri, November 5, 2010)

    ERIC Educational Resources Information Center

    Baudino, Frank, Ed.; Ury, Connie Jo, Ed.; Park, Sarah G., Ed.

    2010-01-01

    Twenty-one scholarly papers and fifteen abstracts comprise the content of the tenth annual Brick and Click Libraries Symposium, held annually at Northwest Missouri State University in Maryville, Missouri. The peer-reviewed proceedings, authored by academic librarians and presented at the symposium, portray the contemporary and future face of…

  5. Brick and Click Libraries: Proceedings of an Academic Libraries Symposium (8th, Maryville, Missouri, November 7, 2008)

    ERIC Educational Resources Information Center

    Baudino, Frank, Ed.; Ury, Connie Jo, Ed.; Park, Sarah G., Ed.

    2008-01-01

    Eighteen scholarly papers and eighteen abstracts comprise the content of the 8th "Brick and Click Libraries Symposium," held annually at Northwest Missouri State University in Maryville, Missouri. The proceedings, authored by academic librarians and presented at the symposium, portray the contemporary and future face of librarianship. Many of the…

  6. Brick and Click Libraries: Proceedings of an Academic Library Symposium (9th, Maryville, Missouri, November 6, 2009)

    ERIC Educational Resources Information Center

    Ury, Connie Jo, Ed.; Baudino, Frank, Ed.; Park, Sarah G., Ed.

    2009-01-01

    Twenty-one scholarly papers and fourteen abstracts comprise the content of the ninth annual "Brick and Click Libraries Symposium," held annually at Northwest Missouri State University in Maryville, Missouri. The peer-reviewed proceedings, authored by academic librarians and presented at the symposium, portray the contemporary and future…

  7. Brick and Click Libraries: Proceedings of an Academic Library Symposium (Northwest Missouri State University, Maryville, Missouri, October 14, 2005)

    ERIC Educational Resources Information Center

    Ury, Connie Jo., Ed.; Baudino, Frank, Ed.

    2005-01-01

    These proceedings document the fifth year of the "Brick and Click Libraries Symposium", held annually at Northwest Missouri State University in Maryville, Missouri. Thirty five peer-reviewed papers and abstracts, written by academic librarians, and presented at the symposium are included in this volume. Many of the entries have…

  8. Brick and Click Libraries: Proceedings of an Academic Library Symposium (6th, Maryville, Missouri, November 3, 2006)

    ERIC Educational Resources Information Center

    Baudino, Frank, Ed.; Ury, Connie Jo, Ed.; Park, Sarah G., Ed.

    2006-01-01

    These proceedings document the sixth year of the "Brick and Click Libraries Symposium," held annually at Northwest Missouri State University in Maryville, Missouri, on November 3, 2006. Thirty-four peer-reviewed papers and abstracts, written by academic librarians, and presented at the symposium are included in this volume. Many of the…

  9. Brick and Click Libraries: Changes and Challenges. Proceedings of a Regional Academic Library Symposium (Maryville, Missouri, October 18, 2002).

    ERIC Educational Resources Information Center

    Ury, Connie Jo, Ed.; Wainscott, Vicki, Ed.

    This proceedings of the Brick and Click Libraries Symposium contains the following papers: (1) "Electronic Journals: Vendor Solutions to Access Issues" (Nona Barton); (2) "Tips on Funding" (Janice Borey); (3) "Why Are So Many Web Pages Still So Hard To Use?" (Jerry R. Brown); (4) "The Secrets of Full-Text Databases: The Overlap between a Same…

  10. Brick & Click Libraries: An Academic Library Conference (14th, Maryville, Missouri, November 7, 2014)

    ERIC Educational Resources Information Center

    Baudino, Frank, Ed.; Johnson, Carolyn, Ed.

    2014-01-01

    Eighteen scholarly papers and twelve abstracts comprise the content of the fourteenth annual Brick and Click Libraries Symposium, held annually at Northwest Missouri State University in Maryville, Missouri. The proceedings, authored by academic librarians and presented at the symposium, portray the contemporary and future face of librarianship.…

  11. Brick & Click Libraries: An Academic Library Symposium (13th, Maryville, Missouri, November 1, 2013)

    ERIC Educational Resources Information Center

    Baudino, Frank, Ed.; Johnson, Carolyn, Ed.; Park, Sarag G., Ed.

    2013-01-01

    Twenty-six scholarly papers and ten abstracts comprise the content of the thirteenth annual Brick and Click Libraries Symposium, held annually at Northwest Missouri State University in Maryville, Missouri. The proceedings, authored by academic librarians and presented at the symposium, portray the contemporary and future face of librarianship. The…

  12. Brick & Click Libraries: An Academic Library Conference (15th, Maryville, Missouri, November 6, 2015)

    ERIC Educational Resources Information Center

    Baudino, Frank, Ed.; Johnson, Carolyn, Ed.

    2015-01-01

    Nineteen scholarly papers and seventeen abstracts comprise the content of the fifteenth annual Brick and Click Libraries Conference, held annually at Northwest Missouri State University in Maryville, Missouri. The proceedings, authored by academic librarians and presented at the symposium, portray the contemporary and future face of librarianship.…

  13. Brick and Click Libraries: Proceedings of an Academic Library Symposium (Maryville, Missouri, October 22, 2004)

    ERIC Educational Resources Information Center

    Baudino, Frank, Ed.; Mardis, Lori, Ed.; Park, Sarah G., Ed.; Ury, Connie J., Ed.

    2004-01-01

    The Brick & Click Libraries Symposium is a one-day conference that focuses on providing library resources and services for students who are either on-campus learners or off-campus learners. It is sponsored by Northwest Missouri State University in order to offer academic librarians a forum for sharing practical information. The subjects and…

  14. Brick and Click Libraries: An Academic Library Symposium (12th, Maryville, Missouri, October 26, 2012)

    ERIC Educational Resources Information Center

    Baudino, Frank, Ed.; Johnson, Carolyn, Ed.

    2012-01-01

    Twenty scholarly papers and fifteen abstracts comprise the content of the twelfth annual Brick and Click Libraries Symposium, held at Northwest Missouri State University in Maryville, Missouri. The peer-reviewed proceedings, authored by academic librarians and presented at the symposium, portray the contemporary and future face of librarianship.…

  15. Brick and Click Libraries: Proceedings of a Regional Academic Library Symposium (Missouri State University, Maryville, Missouri, October 10, 2003)

    ERIC Educational Resources Information Center

    Ury, Connie Jo, Ed.; Baudino, Frank, Ed.

    2003-01-01

    The 2003 Brick and Click is a one-day conference that focuses on providing library resources and services for students who are either on-campus learners or off-campus learners. The conference theme was "The Shape of Tomorrow". It is sponsored by the Northwest Missouri State University in order to offer academic librarians a forum for…

  16. 2017 Brick & Click: An Academic Conference (17th, Maryville, Missouri, November 3, 2017)

    ERIC Educational Resources Information Center

    Baudino, Frank, Ed.; Hart, Kathy, Ed.; Johnson, Carolyn, Ed.

    2017-01-01

    Eighteen scholarly papers and fifteen abstracts comprise the content of the seventeenth annual Brick and Click Libraries Conference, held annually at Northwest Missouri State University in Maryville, Missouri. The proceedings, authored by academic librarians and presented at the symposium, portray the contemporary and future face of librarianship.…

  17. 77 FR 76020 - Combined Notice of Filings #1

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-26

    ..., Longview Fibre Paper and Packaging, Inc., Rumford Falls Hydro LLC, Brookfield Smoky Mountain Hydropower LLC...'s eLibrary system by clicking on the links or querying the docket number. Any person desiring to... proceeding. eFiling is encouraged. More detailed information relating to filing requirements, interventions...

  18. 77 FR 71412 - Combined Notice of Filings #2

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-30

    ... party to the proceeding. The filings are accessible in the Commission's eLibrary system by clicking on the links or querying the docket number. eFiling is encouraged. More detailed information relating to... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 2 Take notice...

  19. 76 FR 30329 - Combined Notice of Filings #1

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-25

    ...: Termination of Morgantown POD Construction Agreement to be effective 7/ 4/2011. Filed Date: 05/18/2011... Filing in Response to the September 3, 2010 Order Approving Petition and Directing Compliance Filing.... The filings in the above proceedings are accessible in the Commission's eLibrary system by clicking on...

  20. 77 FR 5008 - Solios Power Mid-Atlantic Virtual LLC; Supplemental Notice That Initial Market-Based Rate Filing...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-01

    ...-referenced proceeding are accessible in the Commission's eLibrary system by clicking on the appropriate link... Mid-Atlantic Virtual LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request... of Solios Power Mid-Atlantic Virtual LLC's application for market-based rate authority, with an...

  1. 77 FR 41178 - Combined Notice of Filings #1

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-12

    ...)(2)(iii): Filing of First Revised Service Agreement No. 2924; Queue No. W2-016 to be effective 6/7.... Comments Due: 5 p.m. ET 7/23/12. The filings are accessible in the Commission's eLibrary system by clicking... above proceedings must file in accordance with Rules 211 and 214 of the Commission's Regulations (18 CFR...

  2. 77 FR 65874 - Kinder Morgan Pony Express Pipeline LLC, Hiland Crude, LLC; Notice of Petition For Declaratory Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-31

    ..., but intervention is necessary to become a party to the proceeding. The filings are accessible in the Commission's eLibrary system by clicking on the links or querying the docket number. eFiling is encouraged... terms, as described in filing. Any person desiring to intervene or protest in any of the above...

  3. DEA Multimedia Drug Library: Marijuana

    MedlinePlus

    ... confidencial Press Room » Multi-Media Library » Image Gallery » Marijuana MARIJUANA To Save Images: First click on the thumbnail ... Save in directory and then click Save. Indoor Marijuana Grow Indoor Marijuana Grow Loose Marijuana Marinol 10mg ...

  4. 77 FR 277 - Sabine Pass Liquefaction, LLC and Sabine Pass LNG, L.P; Notice of Availability of the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-04

    ... Web site ( www.ferc.gov ) using the eLibrary link. A limited number of copies of the EA are available..., or on the FERC Web site ( www.ferc.gov ) using the eLibrary link. Click on the eLibrary link, click... systems, induced draft air coolers, fire and gas detection and safety systems, control systems, and...

  5. AutoClickChem: click chemistry in silico.

    PubMed

    Durrant, Jacob D; McCammon, J Andrew

    2012-01-01

    Academic researchers and many in industry often lack the financial resources available to scientists working in "big pharma." High costs include those associated with high-throughput screening and chemical synthesis. In order to address these challenges, many researchers have in part turned to alternate methodologies. Virtual screening, for example, often substitutes for high-throughput screening, and click chemistry ensures that chemical synthesis is fast, cheap, and comparatively easy. Though both in silico screening and click chemistry seek to make drug discovery more feasible, it is not yet routine to couple these two methodologies. We here present a novel computer algorithm, called AutoClickChem, capable of performing many click-chemistry reactions in silico. AutoClickChem can be used to produce large combinatorial libraries of compound models for use in virtual screens. As the compounds of these libraries are constructed according to the reactions of click chemistry, they can be easily synthesized for subsequent testing in biochemical assays. Additionally, in silico modeling of click-chemistry products may prove useful in rational drug design and drug optimization. AutoClickChem is based on the pymolecule toolbox, a framework that may facilitate the development of future python-based programs that require the manipulation of molecular models. Both the pymolecule toolbox and AutoClickChem are released under the GNU General Public License version 3 and are available for download from http://autoclickchem.ucsd.edu.

  6. AutoClickChem: Click Chemistry in Silico

    PubMed Central

    Durrant, Jacob D.; McCammon, J. Andrew

    2012-01-01

    Academic researchers and many in industry often lack the financial resources available to scientists working in “big pharma.” High costs include those associated with high-throughput screening and chemical synthesis. In order to address these challenges, many researchers have in part turned to alternate methodologies. Virtual screening, for example, often substitutes for high-throughput screening, and click chemistry ensures that chemical synthesis is fast, cheap, and comparatively easy. Though both in silico screening and click chemistry seek to make drug discovery more feasible, it is not yet routine to couple these two methodologies. We here present a novel computer algorithm, called AutoClickChem, capable of performing many click-chemistry reactions in silico. AutoClickChem can be used to produce large combinatorial libraries of compound models for use in virtual screens. As the compounds of these libraries are constructed according to the reactions of click chemistry, they can be easily synthesized for subsequent testing in biochemical assays. Additionally, in silico modeling of click-chemistry products may prove useful in rational drug design and drug optimization. AutoClickChem is based on the pymolecule toolbox, a framework that may facilitate the development of future python-based programs that require the manipulation of molecular models. Both the pymolecule toolbox and AutoClickChem are released under the GNU General Public License version 3 and are available for download from http://autoclickchem.ucsd.edu. PMID:22438795

  7. Betty Petersen Memorial Library

    Science.gov Websites

    NOAA logo - Click to go to the NOAA homepage Betty Petersen Memorial Library NOAA Library Logo / NOAA Central Library Betty Petersen Memorial Library 5830 University Research Court Room 1650, E / OC4

  8. University of Maryland Research Affiliate

    Science.gov Websites

    NOAA logo - Click to go to the NOAA homepage Betty Petersen Memorial Library NOAA Library Logo login! DOC/ NOAA/ NOAA Central Library Betty Petersen Memorial Library 5830 University Research Court

  9. Betty Petersen Memorial Library

    Science.gov Websites

    NOAA logo - Click to go to the NOAA homepage Betty Petersen Memorial Library NOAA Library Logo ... library image Betty Petersen Memorial Library is a branch of the NOAA Central Library jointly funded by / NOAA Central Library Betty Petersen Memorial Library 5830 University Research Court Room 1650, E / OC4

  10. Betty Petersen Memorial Library - NCWCP Publications - NWS

    Science.gov Websites

    NOAA logo - Click to go to the NOAA homepage Betty Petersen Memorial Library NOAA Library Logo Memorial Library 5830 University Research Court Room 1650, E / OC4 College Park, Maryland 20740 BPML

  11. Cocaine

    MedlinePlus

    ... confidencial Press Room » Multi-Media Library » Image Gallery » Cocaine COCAINE To Save Images: First click on the thumbnail ... your Save in directory and then click Save. Cocaine Crack Cocaine RESOURCE CENTER Controlled Substances Act DEA ...

  12. Contact Information - Betty Petersen Memorial Library

    Science.gov Websites

    NOAA logo - Click to go to the NOAA homepage Betty Petersen Memorial Library NOAA Library Logo Center for Weather and Climate Prediction Betty Petersen Memorial Library 5830 University Research Court Send Comments DOC/ NOAA/ NOAA Central Library Betty Petersen Memorial Library 5830 University Research

  13. The World Wide Web: A Web Even a Fly Would Love

    NASA Astrophysics Data System (ADS)

    Bryson, E.

    Ever since my introduction to the World Wide Web (WWW), it's been love at first byte. Searching on the WWW is similar to being able to go to a public library and allow yourself to be transported to any other book or library around the world by looking at a reference or index and clicking your heels together like Dorothy did in "The Wizard of Oz", only the clicking is done with a computer mouse. During this presentation, we will explore the WWW protocols which allow clients and servers to communicate on the Internet. We will demonstrate the ease with which users can navigate the virtual tidal wave of information available with a mere click of a button. In addition, the workshop will discuss the revolutionary aspects of this network information system and how it's impacting our libraries as a primary mechanism for rapid dissemination of knowledge.

  14. Growing Applications of “Click Chemistry” for Bioconjugation in Contemporary Biomedical Research

    PubMed Central

    Nwe, Kido

    2009-01-01

    Summation This update summarizes the growing application of “click” chemistry in diverse areas such as bioconjugation, drug discovery, materials science, and radiochemistry. This update also discusses click chemistry reactions that proceed rapidly with high selectivity, specificity, and yield. Two important characteristics make click chemistry so attractive for assembling compounds, reagents, and biomolecules for preclinical and clinical applications. First, click reactions are bio-orthogonal; neither the reactants nor their product's functional groups interact with functionalized biomolecules. Second, the reactions proceed with ease under mild nontoxic conditions, such as at room temperature and, usually, in water. The copper-catalyzed Huisgen cycloaddition, azide-alkyne [3 + 2] dipolar cycloaddition, Staudinger ligation, and azide-phosphine ligation each possess these unique qualities. These reactions can be used to modify one cellular component while leaving others unharmed or untouched. Click chemistry has found increasing applications in all aspects of drug discovery in medicinal chemistry, such as for generating lead compounds through combinatorial methods. Bioconjugation via click chemistry is rigorously employed in proteomics and nucleic research. In radiochemistry, selective radiolabeling of biomolecules in cells and living organisms for imaging and therapy has been realized by this technology. Bifunctional chelating agents for several radionuclides useful for positron emission tomography and single-photon emission computed tomography imaging have also been prepared by using click chemistry. This review concludes that click chemistry is not the perfect conjugation and assembly technology for all applications, but provides a powerful, attractive alternative to conventional chemistry. This chemistry has proven itself to be superior in satisfying many criteria (e.g., biocompatibility, selectivity, yield, stereospecificity, and so forth); thus, one can expect it will consequently become a more routine strategy in the near future for a wide range of applications. PMID:19538051

  15. Regenerative biomaterials that "click": simple, aqueous-based protocols for hydrogel synthesis, surface immobilization, and 3D patterning.

    PubMed

    Nimmo, Chelsea M; Shoichet, Molly S

    2011-11-16

    The click chemistry era has generated a library of versatile "spring-loaded" reactions that offer high yields, regio- and stereospecificity, and outstanding functional group tolerance. These powerful transformations are particularly advantageous for the design of sophisticated biomaterials that require high levels of precision and control, namely, materials that promote tissue regeneration such as hydrogels, 2D functionalized substrates, and 3D biomimetic scaffolds. In this review, the synthesis and application of regenerative biomaterials via click chemistry are summarized. Particular emphasis is placed on the copper(I)-catalyzed alkyne-azide cycloaddition, Diels-Alder cycloadditions, and thiol-click coupling.

  16. Diversity-oriented synthesis of a library of substituted tetrahydropyrones using oxidative carbon-hydrogen bond activation and click chemistry.

    PubMed

    Zaware, Nilesh; Laporte, Matthew G; Farid, Ramy; Liu, Lei; Wipf, Peter; Floreancig, Paul E

    2011-05-02

    Eighteen (2RS,6RS)-2-(4-methoxyphenyl)-6-(substituted ethyl)dihydro-2H-pyran-4(3H)ones were synthesized via a DDQ-mediated oxidative carbon-hydrogen bond activation reaction. Fourteen of these tetrahydropyrans were substituted with triazoles readily assembled via azide-alkyne click-chemistry reactions. Examples of a linked benzotriazole and pyrazole motif were also prepared. To complement the structural diversity, the alcohol substrates were obtained from stereoselective reductions of the tetrahydropyrone. This library provides rapid access to structurally diverse non-natural compounds to be screened against a variety of biological targets.

  17. NOAA Photo Library - Sanctuaries

    Science.gov Websites

    whale tail The word sanctuary evokes images of a sacred place, a refuge from the dangers of the world images contained in the collection. Click on thumbnails to view larger images. ALBUMS Images are arranged by themes. Click on thumbnails to view larger images. Note that not all images are contained in the

  18. NOAA Photo Library - NOAA's Ark/Animals Album

    Science.gov Websites

    options banner CATALOG View ALL images contained in the collection. Click on thumbnails to view larger images. ALBUMS Images are arranged by themes. Click on thumbnails to view larger images. Note that not all images are contained in the albums - select the above option to view ALL current images. NOAA's

  19. Mass spectrometric screening of ligands with lower off-rate from a clicked-based pooled library.

    PubMed

    Arai, Satoshi; Hirosawa, Shota; Oguchi, Yusuke; Suzuki, Madoka; Murata, Atsushi; Ishiwata, Shin'ichi; Takeoka, Shinji

    2012-08-13

    This paper describes a convenient screening method using ion trap electrospray ionization mass spectrometry to classify ligands to a target molecule in terms of kinetic parameters. We demonstrate this method in the screening of ligands to a hexahistidine tag from a pooled library synthesized by click chemistry. The ion trap mass spectrometry analysis revealed that higher stabilities of ligand-target complexes in the gas phase were related to lower dissociation rate constants, i.e., off-rates in solution. Finally, we prepared a fluorescent probe utilizing the ligand with lowest off-rate and succeeded in performing single molecule observations of hexahistidine-tagged myosin V walking on actin filaments.

  20. In situ click chemistry: a powerful means for lead discovery.

    PubMed

    Sharpless, K Barry; Manetsch, Roman

    2006-11-01

    Combinatorial chemistry and parallel synthesis are important and regularly applied tools for lead identification and optimisation, although they are often accompanied by challenges related to the efficiency of library synthesis and the purity of the compound library. In the last decade, novel means of lead discovery approaches have been investigated where the biological target is actively involved in the synthesis of its own inhibitory compound. These fragment-based approaches, also termed target-guided synthesis (TGS), show great promise in lead discovery applications by combining the synthesis and screening of libraries of low molecular weight compounds in a single step. Of all the TGS methods, the kinetically controlled variant is the least well known, but it has the potential to emerge as a reliable lead discovery method. The kinetically controlled TGS approach, termed in situ click chemistry, is discussed in this article.

  1. The Off-Campus Library Services Conference Proceedings (7th, San Diego, California, October 25-27, 1995).

    ERIC Educational Resources Information Center

    Jacob, Carol J., Comp.

    This conference proceedings of off-campus library services includes 37 papers covering the following topics: ensuring excellence in distance library services; DePaul University's research consultation service; using videos to promote library service; a virtual academic library project in England; student-centered library instruction off campus;…

  2. 78 FR 34091 - Sierrita Gas Pipeline LLC; Notice of Public Meeting for the Proposed Sierrita Pipeline Project

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-06

    ... Sierrita Pipeline Project right-of-way. The meeting is open to the public; however, the intent of the..., or on the FERC Web site at www.ferc.gov using the ``eLibrary'' link. Click on the eLibrary link...

  3. Library links on medical school home pages.

    PubMed

    Thomas, Sheila L

    2011-01-01

    The purpose of this study was to assess the websites of American Association of Medical Colleges (AAMC)-member medical schools for the presence of library links. Sixty-one percent (n = 92) of home pages of the 150 member schools of the AAMC contain library links. For the 58 home pages not offering such links, 50 provided a pathway of two or three clicks to a library link. The absence of library links on 39% of AAMC medical school home pages indicates that the designers of those pages did not consider the library to be a primary destination for their visitors.

  4. Proceedings of the Annual Meeting of the Association for Education in Journalism and Mass Communication (83rd, Phoenix, Arizona, August 9-12, 2000). Advertising Division.

    ERIC Educational Resources Information Center

    Association for Education in Journalism and Mass Communication.

    The Advertising Division section of the proceedings contains the following 14 papers: "The Effectiveness of Banner Advertisements: Involvement and Click-Through" (Chang-Hoan Cho and John D. Leckenby); "Messages of Hope: Developing Health Campaigns that Address Misperceptions of Breast Cancer Held by Women of Color" (Cynthia M.…

  5. 77 FR 67363 - Notice of Suspension and Commencement of Proposed Debarment Proceedings; Schools and Libraries...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-09

    ... Debarment Proceedings; Schools and Libraries Universal Service Support Mechanism AGENCY: Federal.... Denisa Babcock's suspension from the schools and libraries universal service support mechanism (or ``E... schools and libraries support, may respond by filing an opposition request, supported by documentation to...

  6. Training Presentation for NASA Civil Helicopter Safety Website

    NASA Technical Reports Server (NTRS)

    Iseler, Laura

    2002-01-01

    NASA civil helicopter safety News & Updates include the following: Mar. 2002. The Air Medical Operations Survey has been completed! Check it out! Also accessible via the Mission pages under Air Medical Mission. Air Medical and Law Enforcement Mission pages have been added. They are accessible via the Mission pages. The Public Use, Personal, Offshore, Law Enforcement, External Load, Business and Gyro accident pages (accessable via the Mission page) have been updated. Feb. 2002. A Words of Wisdom section has been added. You can access it by clicking the Library button. A link to a Corporate Accident Response Plan has been added to the Accident page. The AMs, Aerial Application and Instruction accident pages (accessable via the Mission page) have been updated. Jan. 2002. A new searchable safety article database has been added. You can access it by clicking the Library button. The 2001 accident summaries have been updated and the statistics have been compiled - check it out by clicking the accident tab to the left. Dec. 2001. Please read the FAA Administrator's memo regarding the latest FBI warning. 3ee the FAA column - Fall 2001 Read it now!

  7. 76 FR 74781 - Sawgrass Storage LLC; Notice of Availability of the Environmental Assessment for the Proposed...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-01

    ... Affairs, at (866) 208-FERC, or on the FERC Web site ( http://www.ferc.gov ) using the eLibrary link. Click... Midcontinent Express Pipeline's interstate pipeline system; and appurtenant facilities. The FERC staff mailed... interested individuals and groups; newspapers and libraries in the project area; and parties to this...

  8. MedlinePlus Tour

    MedlinePlus

    ... captioning, click the CC button on the lower right-hand corner of the player. Video player keyboard shortcuts Transcript Welcome to MedlinePlus, the consumer health information website from the National Library of ...

  9. Proceedings of the Convocation on Providing Public Library Service to California's 21st Century Population (Sacramento, California, May 22-23, 1997).

    ERIC Educational Resources Information Center

    Keller, Shelly G., Ed.

    The California State Library convened the Convocation on Providing Public Library Service to California's 21st Century Population with the goal of creating a vision of public library service in California. Over 100 library leaders and supporters gathered for two days of meetings and work sessions. These proceedings are designed to give a detailed…

  10. The Off-Campus Library Services Conference Proceedings (6th, Kansas City, Missouri, October 6-8, 1993).

    ERIC Educational Resources Information Center

    Jacob, Carol J., Comp.

    This conference proceedings of off-campus library services includes 30 papers covering the following topics: extracting the hidden potential of course syllabi; obstacles to user education for off-campus students; using Hypercard in an off-campus library environment; satisfying accreditation requirements in lean times; the library's role in…

  11. Libraries Without Walls 4: The Delivery of Library Services to Distant Users. Proceedings of an International Conference Organized by the Centre for Research in Library and Information Management (CERLIM), Manchester Metropolitan University (Manchester, England, September 14-18, 2001).

    ERIC Educational Resources Information Center

    Brophy, Peter, Ed.; Fisher, Shelagh, Ed.; Clarke, Zoe, Ed.

    This proceedings of the fourth Libraries Without Walls Conference addresses key strategic issues arising from international, regional, and cross-sectoral approaches to the provision of library services to distant users. The following papers are included: Theme 1: Libraries and Virtual Learning Environments: "Introduction" (Peter Brophy,…

  12. 77 FR 62505 - Combined Notice of Filings #2

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-15

    ...-2654-000. Applicants: World Digital Innovations. Description: World Digital Innovations submits tariff...Library system by clicking on the links or querying the docket number. Any person desiring to intervene or...

  13. 78 FR 23553 - Trunkline Gas Company, LLC; Notice of Availability of the Environmental Assessment for the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-19

    ... available for public viewing on the FERC's Web site ( www.ferc.gov ) using the eLibrary link. A limited... Affairs, at (866) 208-FERC, or on the FERC Web site ( www.ferc.gov ) using the eLibrary link. Click on the... systems and portions of compressor stations (CS) located in numerous counties in Illinois, Kentucky...

  14. The Role of State Library Agencies in the Evolving National Information Network. Proceedings of the Joint Meeting of the Library of Congress Network Advisory Committee and the Chief Officers of State Library Agencies (Washington, D.C., April 27-29, 1992). Network Planning Paper No. 23.

    ERIC Educational Resources Information Center

    Library of Congress, Washington, DC. Network Development and MARC Standards Office.

    The papers in this proceedings describe similarities and differences in state libraries and examine the state library role in local, regional, and national network development and in the dissemination of information to various client segments. The papers are: (1) "The Commonalities of State Library Agencies" (Barrat Wilkins); (2)…

  15. General Dialdehyde Click Chemistry for Amine Bioconjugation.

    PubMed

    Elahipanah, Sina; O'Brien, Paul J; Rogozhnikov, Dmitry; Yousaf, Muhammad N

    2017-05-17

    The development of methods for conjugating a range of molecules to primary amine functional groups has revolutionized the fields of chemistry, biology, and material science. The primary amine is a key functional group and one of the most important nucleophiles and bases used in all of synthetic chemistry. Therefore, tremendous interest in the synthesis of molecules containing primary amines and strategies to devise chemical reactions to react with primary amines has been at the core of chemical research. In particular, primary amines are a ubiquitous functional group found in biological systems as free amino acids, as key side chain lysines in proteins, and in signaling molecules and metabolites and are also present in many natural product classes. Due to its abundance, the primary amine is the most convenient functional group handle in molecules for ligation to other molecules for a broad range of applications that impact all scientific fields. Because of the primary amine's central importance in synthetic chemistry, acid-base chemistry, redox chemistry, and biology, many methods have been developed to efficiently react with primary amines, including activated carboxylic acids, isothiocyanates, Michael addition type systems, and reaction with ketones or aldehydes followed by in situ reductive amination. Herein, we introduce a new traceless, high-yield, fast click-chemistry method based on the rapid and efficient trapping of amine groups via a functionalized dialdehyde group. The click reaction occurs in mild conditions in organic solvents or aqueous media and proceeds in high yield, and the starting dialdehyde reagent and resulting dialdehyde click conjugates are stable. Moreover, no catalyst or dialdehyde-activating group is required, and the only byproduct is water. The initial dialdehyde and the resulting conjugate are both straightforward to characterize, and the reaction proceeds with high atom economy. To demonstrate the broad scope of this new click-conjugation strategy, we designed a straightforward scheme to synthesize a suite of dialdehyde reagents. The dialdehyde molecules were used for applications in cell-surface engineering and for tailoring surfaces for material science applications. We anticipate the broad utility of the general dialdehyde click chemistry to primary amines in all areas of chemical research, ranging from polymers and bioconjugation to material science and nanoscience.

  16. CuAAC click chemistry accelerates the discovery of novel chemical scaffolds as promising protein tyrosine phosphatases inhibitors.

    PubMed

    He, X-P; Xie, J; Tang, Y; Li, J; Chen, G-R

    2012-01-01

    Protein tyrosine phosphatases (PTPs) are crucial regulators for numerous biological processes in nature. The dysfunction and overexpression of many PTP members have been demonstrated to cause fatal human diseases such as cancers, diabetes, obesity, neurodegenerative diseases and autoimmune disorders. In the past decade, considerable efforts have been devoted to the production of PTPs inhibitors by both academia and the pharmaceutical industry. However, there are only limited drug candidates in clinical trials and no commercial drugs have been approved, implying that further efficient discovery of novel chemical entities competent for inhibition of the specific PTP target in vivo remains yet a challenge. In light of the click-chemistry paradigm which advocates the utilization of concise and selective carbon-heteroatom ligation reactions for the modular construction of useful compound libraries, the Cu(I)-catalyzed azidealkyne 1,3-dipolar cycloaddition reaction (CuAAC) has fueled enormous energy into the modern drug discovery. Recently, this ingenious chemical ligation tool has also revealed efficacious and expeditious in establishing large combinatorial libraries for the acquisition of novel PTPs inhibitors with promising pharmacological profiles. We thus offer here a comprehensive review highlighting the development of PTPs inhibitors accelerated by the CuAAC click chemistry.

  17. Copper-free click chemistry for dynamic in vivo imaging

    PubMed Central

    Baskin, Jeremy M.; Prescher, Jennifer A.; Laughlin, Scott T.; Agard, Nicholas J.; Chang, Pamela V.; Miller, Isaac A.; Lo, Anderson; Codelli, Julian A.; Bertozzi, Carolyn R.

    2007-01-01

    Dynamic imaging of proteins in live cells is routinely performed by using genetically encoded reporters, an approach that cannot be extended to other classes of biomolecules such as glycans and lipids. Here, we report a Cu-free variant of click chemistry that can label these biomolecules rapidly and selectively in living systems, overcoming the intrinsic toxicity of the canonical Cu-catalyzed reaction. The critical reagent, a substituted cyclooctyne, possesses ring strain and electron-withdrawing fluorine substituents that together promote the [3 + 2] dipolar cycloaddition with azides installed metabolically into biomolecules. This Cu-free click reaction possesses comparable kinetics to the Cu-catalyzed reaction and proceeds within minutes on live cells with no apparent toxicity. With this technique, we studied the dynamics of glycan trafficking and identified a population of sialoglycoconjugates with unexpectedly rapid internalization kinetics. PMID:17942682

  18. Design and synthesis via click chemistry of 8,9-anhydroerythromycin A 6,9-hemiketal analogues with anti-MRSA and -VRE activity.

    PubMed

    Sugawara, Akihiro; Sunazuka, Toshiaki; Hirose, Tomoyasu; Nagai, Kenichiro; Yamaguchi, Yukie; Hanaki, Hideaki; Sharpless, K Barry; Omura, Satoshi

    2007-11-15

    An erythromycin analogue, 11,12-di-O-iso-butyryl-8,9-anhydroerythromycin A 6,9-hemiketal (1b), was found to be a potential anti-MRSA and anti-VRE agent. The use of copper catalyzed azide-acetylene cycloaddition, and click chemistry, readily provided 10 types of triazole analogues of 1b in good to nearly quantitative yield. Among the library, 5b exhibited activity against MRSA and VRE bacterial strains, representing more than twice the potency of 1b.

  19. 76 FR 43318 - Combined Notice of Filings #1

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-20

    ... Porterville, CA Roof Top Solor Project to be effective 7/14/2011. Filed Date: 07/13/2011. Accession Number... the Commission's eLibrary system by clicking on the appropriate link in the above list. They are also...

  20. 77 FR 37394 - Combined Notice of Filings #1

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-21

    ...: Revisions to the Tariff Att Q to modify PJM's Credit Standards for Virtual Bids to be effective 8/8/2012.../12. The filings are accessible in the Commission's eLibrary system by clicking on the links or...

  1. Developing a Website Directory for Young People: A Case Study Using Graduate Students in Library and Information Science

    ERIC Educational Resources Information Center

    Irwin, Enid; Haycock, Ken

    2008-01-01

    KidsClick! is a web-based instructional resource designed for K-12. In 2006 it was transferred to the San Jose State School of Library and Information Science, and was subsequently refocused for grades 4-9, ages 10-14, post-reading, and pre-adult reading level phases. This article describes three parts of the redesign project--content, interface,…

  2. "Click Here to Order This Book": A Case Study of Print and Electronic Patron-Driven Acquisition in University College Dublin

    ERIC Educational Resources Information Center

    Tynan, Mark; McCarney, Eoin

    2014-01-01

    University College Dublin became the first library in the Republic of Ireland to trial patron-driven acquisition (PDA) as a collection development tool in 2013. A total of 42% of UCD Library's book budget was allocated to the project, which included both electronic and print books. This article describes the twelve month project from the tender…

  3. Libraries and the National Information Infrastructure: Proceedings of the Forum on Library and Information Services Policy (2nd, Washington, D.C., May 16-17, 1994).

    ERIC Educational Resources Information Center

    National Commission on Libraries and Information Science, Washington, DC.

    The 1994 Forum on Library and Information Services was planned to provide an opportunity to explore the role of libraries in the evolving information and communications infrastructure. This report on the proceedings of the Forum begins with the agenda and a list of the participants. Two roles of the Department of Education relating to libraries…

  4. 78 FR 36765 - Combined Notice of Filings #1

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-19

    ... & OA re Up-to-Congestion & Virtual Transactions to be effective 8/9/2013. Filed Date: 6/10/13.... Comments Due: 5 p.m. ET 6/17/13. The filings are accessible in the Commission's eLibrary system by clicking...

  5. International Conference of Directors of National Libraries on Resource Sharing in Asia and Oceanic [Proceedings] (Canberra, Australia, May 14-18, 1979). Development of Resource Sharing Networks. Networks Study No. 11.

    ERIC Educational Resources Information Center

    National Library of Australia, Canberra.

    The proceedings of this 1979 conference on library cooperation begin with proposals for the promotion of resource sharing among the national libraries of Asia and Oceania, the text of a policy statement on the role of national and international systems as approved at a 1976 meeting of directors of national libraries held in Lausanne, and a summary…

  6. Off-Campus Library Services Conference Proceedings (8th, Providence, Rhode Island, April 22-24, 1998).

    ERIC Educational Resources Information Center

    Thomas, P. Steven, Comp.; Jones, Maryhelen, Comp.

    The 27 papers that make up this Proceedings were presented at the Eighth Off-Campus Library Services Conference. The primary objective of the conference was to provide a forum where practitioners involved in library services for off-campus constituents could gather to exchange relevant ideas, concerns and perspectives, and to share research.…

  7. Proceedings of the HEA Title II-B Institute on Continuing Education Program Planning for Library Staffs in the Southwest, March 17-28, 1975.

    ERIC Educational Resources Information Center

    Foos, Donald D., Comp.

    The proceedings of the Institute on Continuing Education Program Planning for Library Staffs in the Southwest contain historical and state-of-the-art information, needs assessments, program planning information, program descriptions and the Continuing Education for Library Staff program. The continuing education needs of medical, school, special,…

  8. Cooperative Collection Development in Multitype Library Networks: A Beginning--Goals and Methods. Proceedings of the Annual Conference of the Missouri Library Association (1980).

    ERIC Educational Resources Information Center

    Tompkins, Philip, Ed.

    This document presents the proceedings of a conference organized to review the cooperative collection development features of the Missouri State Network Plan and to outline specific goals, methods, and materials for facilitating cooperative collection development projects in the state's multitype library networks. An introduction provides…

  9. Computers in Libraries, 2000: Proceedings (15th, Washington, D.C., March 15-17, 2000).

    ERIC Educational Resources Information Center

    Nixon, Carol, Comp.; Burmood, Jennifer, Comp.

    Topics of the Proceedings of the 15th Annual Computers in Libraries Conference (March 15-17, 2000) include: Linux and open source software in an academic library; a Master Trainer Program; what educators need to know about multimedia and copyright; how super searchers find business information online; managing print costs; new technologies in wide…

  10. Planning Library Services; Proceedings of a Research Seminar (University of Lancaster 9-11 July 1969).

    ERIC Educational Resources Information Center

    Mackenzie, A. Graham, Ed.; Stuart, Ian M., Ed.

    This proceedings volume of a seminar on planning library services is the third in a series of papers, published at irregular intervals, to report on research work by members of the University of Lancaster library staff. From January 1967 until June 1969 the Office of Scientific and Technical Information (OSTI) organized regular meetings under the…

  11. GLCF: Services

    Science.gov Websites

    Services Contact Site Map Go Services GLCF General Services Contact us with the online form. Answer classification Special Group Services Special workspaces for groups accessing datasets Data Ordering Services Click here to proceed to Data Ordering Service Hard Media Orders Metrics Services ESDS Metrics

  12. Libraries for Life: Democracy, Diversity, Delivery. IFLA Council and General Conference: Conference Programme and Proceedings (68th, Glasgow, Scotland, August 18-24, 2002).

    ERIC Educational Resources Information Center

    International Federation of Library Associations and Institutions, The Hague (Netherlands).

    This document presents the program and proceedings from the 68th International Federation of Library Associations and Institutions (IFLA) Conference held in Glasgow, Scotland, August 18-24, 2002. Topics of presentations include: library services for parliaments; needs assessment; the effects of September 11th on information provision and privacy;…

  13. Planning Library Services; Proceedings of a Research Seminar Held at the University of Lancaster 9-11 July 1969.

    ERIC Educational Resources Information Center

    Mackenzie, A. Graham, Ed.; Stuart, Ian M., Ed.

    This proceedings volume of a seminar on planning library services is the third in a series of papers, published at irregular intervals, to report on research work by members of the University of Lancaster library staff. From January 1967 until June 1969 the Office of Scientific and Technical Information (OSTI) organized regular meetings under the…

  14. Academic Libraries: Reaching Up and Stretching Out. Proceedings of the Spring Meeting of the Nebraska Library Association, College and University Section (Crete, Nebraska, May 25, 1990).

    ERIC Educational Resources Information Center

    Giesecke, Joan, Ed.

    This proceedings report provides the papers presented at the 1990 spring meeting. Titles and authors of the seven papers are as follows: (1) "Marketing without a Plan: Seizing Outreach Opportunities as They Occur" (Joan Giesecke, Gail Egbers, Kay Logan-Peters, and Debra Pearson); (2) "Historians and the Academic Library: Traditional…

  15. Academic Libraries: Myths and Realities. Proceedings of the National Conference of the Association of College and Research Libraries (3rd, Seattle, Washington, April 4-7, 1984).

    ERIC Educational Resources Information Center

    Dodson, Suzanne C., Ed.; Menges, Gary L., Ed.

    The 56 papers in this proceedings are divided into three groups--theme, alternative format, and contributed papers. Myths and realities are explored in the first group as they relate to university, college, community, and junior college libraries, and to private sector information utilities. The conference wrap-up session is included in this…

  16. Standards of Practice for West African Libraries; Proceedings of a Seminar Held at the Institute of Librarianship, University of Ibadan, 15-16 April 1967.

    ERIC Educational Resources Information Center

    Dean, John, Ed.

    A seminar on standards for libraries in West Africa was held in April 1967. This proceedings volume presents the papers given by each of the participants. Discussed are the standards for collections, facilities, staff, technical processes and services for public, school, university and special libraries. The purpose was to focus upon the nature,…

  17. Proceedings of the National Conference on Population Library and Information Services (3rd Chapel Hill, N. C., May 14-15, 1970)

    ERIC Educational Resources Information Center

    Kellermann, Priscilla

    Contains the proceedings of the Third National Conference on Population Library and Information Services held in Chapel Hill, North Carolina, May 14-15, 1970. Under the joint sponsorship of the Carolina Population Center and the Population Council of New York, this was the third in a series of annual conference/workshops devoted to library and…

  18. CODEM User Manual

    DTIC Science & Technology

    2010-09-01

    If the registration succeeds, at computer restart, “.cdm” files will be associated to a new icon that is the CODEM logo. Double-clicking on such a...should I proceed? A5 : It is suggested that you add your extensions in a separate Jar file. You will then not be able to use the executable file, but

  19. Dissecting One Click Frauds

    DTIC Science & Technology

    2010-04-23

    zukan. http://zukan.269g.net/. [8] Yahoo! BB ADSL. http://bbpromo.yahoo.co.jp/adsl/type2/index.html. Last accessed April 16, 2010. 21 [9] BBC News. Porn ...Kirda, and C. Kruegel. Is the internet for porn ? An insight into the online adult industry. In Proceedings (online) of the 9th Workshop on Economics

  20. 77 FR 23707 - Combined Notice of Filings #1

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-20

    ...-000. Applicants: NRG Solar Alpine LLC. Description: NRG Solar Alpine, LLC Notice of Self Certification...-000. Applicants: Exelon Corporation. Description: Notice of Material Change in Facts of Exelon... are accessible in the Commission's eLibrary system by clicking on the links or querying the docket...

  1. 78 FR 21925 - Combined Notice of Filings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-12

    ... comment date. The filings are accessible in the Commission's eLibrary system by clicking on the links or querying the docket number. eFiling is encouraged. More detailed information relating to filing... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings Take notice...

  2. Intellectual Property Issues in the Library Network Context. Proceedings of the Library of Congress Network Advisory Committee Meeting (Washington, D.C., March 23-25, 1988). Network Planning Paper Number 17.

    ERIC Educational Resources Information Center

    Library of Congress, Washington, DC. Network Development and MARC Standards Office.

    The first half of the proceedings consists of three papers presented during the program session of a Library of Congress Network Advisory Committee (NAC) meeting. The first, a background paper by Robert L. Oakley, identifies some of the problems that modern information technology has created for the intellectual property system in the United…

  3. Library Buildings, Equipment, and the ADA: Compliance Issues and Solutions. Proceedings of the Library Administration and Management Association Buildings and Equipment Section Preconference (New Orleans, Louisiana, June 24-25, 1993).

    ERIC Educational Resources Information Center

    Cirillo, Susan E., Ed.; Danford, Robert E., Ed.

    These proceedings are the record of the presentations and deliberations of a 1993 Library Administration and Management Association (LAMA) sponsored conference. The speakers at this conference provided insights into the conditions of disability explanations of the intent and the detail of the law, and techniques for meeting the needs of library…

  4. 76 FR 590 - Adjustment or Determination of Compulsory License Rates for Making and Distributing Phonorecords

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-05

    ... LIBRARY OF CONGRESS Copyright Royalty Board [Docket No. 2011-3 CRB Phonorecords II] Adjustment or... Board, Library of Congress. ACTION: Notice announcing commencement of proceeding with request for... proceeding was captioned as ``DPRA'' (which stands for ``Digital Phonorecord Rate Adjustment''). Hereinafter...

  5. Ultra-Fast RAFT-HDA Click Conjugation: An Efficient Route to High Molecular Weight Block Copolymers.

    PubMed

    Inglis, Andrew J; Stenzel, Martina H; Barner-Kowollik, Christopher

    2009-11-02

    The use of the reversible addition fragmentation chain transfer-hetero Diels-Alder (RAFT-HDA) click reaction for the modular construction of block copolymers is extended to the generation of high molecular weight materials. Cyclopentadienyl end-functionalized polystyrene (PS-Cp) prepared via both atom transfer radical polymerization (ATRP) and the RAFT process are conjugated to poly(isobornyl acrylate) (PiBoA) (also prepared via RAFT polymerization) to achieve well-defined block copolymers with molecular weights ranging from 34 000 to over 100 000 g · mol(-1) and with small polydispersities (PDI < 1.2). The conjugation reactions proceeded in a very rapid fashion (less than 10 min in the majority of cases) under ambient conditions of temperature and atmosphere. The present study demonstrates-for the first time-that RAFT-HDA click chemistry can provide access to high molecular weight block copolymers in a simple and straight-forward fashion. Copyright © 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  6. Research recruitment using Facebook advertising: big potential, big challenges.

    PubMed

    Kapp, Julie M; Peters, Colleen; Oliver, Debra Parker

    2013-03-01

    To our knowledge, ours is the first study to report on Facebook advertising as an exclusive mechanism for recruiting women ages 35-49 years residing in the USA into a health-related research study. We directed our survey to women ages 35-49 years who resided in the USA exclusively using three Facebook advertisements. Women were then redirected to our survey site. There were 20,568,960 women on Facebook that met the eligibility criteria. The three ads resulted in 899,998 impressions with a reach of 374,225 women. Of the women reached, 280 women (0.075 %) clicked the ad. Of the women who clicked the ad, nine women (3.2 %) proceeded past the introductory page. Social networking, and in particular Facebook, is an innovative venue for recruiting participants for research studies. Challenges include developing an ad to foster interest without biasing the sample, and motivating women who click the ad to complete the survey. There is still much to learn about this potential method of recruitment.

  7. Concept, Challenge, Conundrum: From Library Skills to Information Literacy. Proceedings of the National Information Literacy Conference Conducted by the University of South Australia Library and the Australian Library and Information Association Information Literacy Special Interest Group (4th, Adelaide, Australia, December 3-5, 1999).

    ERIC Educational Resources Information Center

    Booker, Di, Ed.

    These proceedings from the fourth National Information Literacy Conference (Decemeber 1999) include the keynote addresses and the papers presented in workshop sessions throughout the conference. Acknowledgements by Irene Doskatsch, conference convener, that precedes the introductory piece by Alan Bundy, "Journey Without End..." is…

  8. Transborder Library Forum [Proceedings] = Memorias del Foro Binacional de Bibliotecas (2nd, Hermosillo, Mexico, March 20-21, 1992).

    ERIC Educational Resources Information Center

    1992

    At the second Transborder Library Forum, 181 participants from the United States and Mexico gathered to discuss topics of international librarianship. The proceedings include the following sections: Discurso de Bienvenida (Welcome Speech) (Carlos Salas); "El Etnocentrismo Mexicano y Los Servicios de Informacion" (Mexican Ethnocentrism…

  9. 36 CFR 703.19 - Requests for authenticated copies of Library documents.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... copies of Library documents. 703.19 Section 703.19 Parks, Forests, and Public Property LIBRARY OF... Documents in Certain Legal Proceedings Where the Library Is Not a Party § 703.19 Requests for authenticated copies of Library documents. Requests for authenticated copies of Library documents for purposes of...

  10. 36 CFR 703.19 - Requests for authenticated copies of Library documents.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... copies of Library documents. 703.19 Section 703.19 Parks, Forests, and Public Property LIBRARY OF... Documents in Certain Legal Proceedings Where the Library Is Not a Party § 703.19 Requests for authenticated copies of Library documents. Requests for authenticated copies of Library documents for purposes of...

  11. 36 CFR 703.19 - Requests for authenticated copies of Library documents.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... copies of Library documents. 703.19 Section 703.19 Parks, Forests, and Public Property LIBRARY OF... Documents in Certain Legal Proceedings Where the Library Is Not a Party § 703.19 Requests for authenticated copies of Library documents. Requests for authenticated copies of Library documents for purposes of...

  12. 36 CFR 703.19 - Requests for authenticated copies of Library documents.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... copies of Library documents. 703.19 Section 703.19 Parks, Forests, and Public Property LIBRARY OF... Documents in Certain Legal Proceedings Where the Library Is Not a Party § 703.19 Requests for authenticated copies of Library documents. Requests for authenticated copies of Library documents for purposes of...

  13. Our Experiment in Online, Real-Time Reference.

    ERIC Educational Resources Information Center

    Broughton, Kelly

    2001-01-01

    Describes experiences in providing real-time online reference services to users with remote Web access at the Bowling Green State University library. Discusses the decision making process first used to select HumanClick software to communicate via chat; and the selection of a fee-based customer service product, Virtual Reference Desk. (LRW)

  14. 78 FR 52766 - Combined Notice of Filings #2

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-26

    .... Applicants: Longview Fibre Paper and Packaging, Inc. Description: Notice of Non-Material Change in Status of Longview Fibre Paper and Packaging, Inc. Filed Date: 8/19/13. Accession Number: 20130819-5060. Comments Due... the Commission's eLibrary system by clicking on the links or querying the docket number. Any person...

  15. 78 FR 51718 - Combined Notice of Filings #1

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-21

    ... Energy Marketing LLC, Champion Energy Services, LLC, Champion Energy, LLC. Description: Notice of Change in Status for Champion Energy Marketing LLC, et al. Filed Date: 8/12/13. Accession Number: 20130812....m. ET 8/23/13. The filings are accessible in the Commission's eLibrary system by clicking on the...

  16. Proceeding of the ACM/IEEE-CS Joint Conference on Digital Libraries (1st, Roanoke, Virginia, June 24-28, 2001).

    ERIC Educational Resources Information Center

    Association for Computing Machinery, New York, NY.

    Papers in this Proceedings of the ACM/IEEE-CS Joint Conference on Digital Libraries (Roanoke, Virginia, June 24-28, 2001) discuss: automatic genre analysis; text categorization; automated name authority control; automatic event generation; linked active content; designing e-books for legal research; metadata harvesting; mapping the…

  17. Internet Librarian '98: Proceedings of the Internet Librarian Conference (2nd, Monterey, California, November 1-5, 1998).

    ERIC Educational Resources Information Center

    Nixon, Carol, Comp.; Dengler, M. Heide, Comp.; McHenry, Mare L., Comp.

    This proceedings contains 56 papers, presentation summaries, and/or slide presentations pertaining to the Internet, World Wide Web, intranets, and library systems. Topics include: Web databases in medium sized libraries; Dow Jones Intranet Toolkit; the future of online; Web searching and Internet basics; digital archiving; evolution of the online…

  18. Libraries in Society. Proceedings of the Biennial Conference of the Library Association of Australia (19th, Tasmania, Australia, August 1977).

    ERIC Educational Resources Information Center

    Library Association of Australia, Sidney.

    This collection of 34 papers and speeches presented at the conference covers a wide range of topics pertaining to the role of libraries in contemporary society, including issues in library education, library/community relations, library planning and policy-making, technological trends, library services, and library administration. While several…

  19. In situ click chemistry: from small molecule discovery to synthetic antibodies

    PubMed Central

    Agnew, Heather D.; Lai, Bert; Lee, Su Seong; Lim, Jaehong; Nag, Arundhati; Pitram, Suresh; Rohde, Rosemary; Heath, James R.

    2013-01-01

    Advances in the fields of proteomics, molecular imaging, and therapeutics are closely linked to the availability of affinity reagents that selectively recognize their biological targets. Here we present a review of Iterative Peptide In Situ Click Chemistry (IPISC), a novel screening technology for designing peptide multiligands with high affinity and specificity. This technology builds upon in situ click chemistry, a kinetic target-guided synthesis approach where the protein target catalyzes the conjugation of two small molecules, typically through the azide–alkyne Huisgen cycloaddition. Integrating this methodology with solid phase peptide libraries enables the assembly of linear and branched peptide multiligands we refer to as Protein Catalyzed Capture Agents (PCC Agents). The resulting structures can be thought of as analogous to the antigen recognition site of antibodies and serve as antibody replacements in biochemical and cell-based applications. In this review, we discuss the recent progress in ligand design through IPISC and related approaches, focusing on the improvements in affinity and specificity as multiligands are assembled by target-catalyzed peptide conjugation. We compare the IPISC process to small molecule in situ click chemistry with particular emphasis on the advantages and technical challenges of constructing antibody-like PCC Agents. PMID:22836343

  20. Library Planning Institute; Proceedings, June 23-27, 1975.

    ERIC Educational Resources Information Center

    Clark, Collin, Ed.

    In June 1975, 100 participants spent a week considering the future of California's libraries. Library trustees, Friends, concerned citizens, and librarians from all types of libraries heard talks by state and local government officials, social planners, and eminent librarians. Topics discussed included library planning, librarianship in general,…

  1. Astrophysics Source Code Library -- Now even better!

    NASA Astrophysics Data System (ADS)

    Allen, Alice; Schmidt, Judy; Berriman, Bruce; DuPrie, Kimberly; Hanisch, Robert J.; Mink, Jessica D.; Nemiroff, Robert J.; Shamir, Lior; Shortridge, Keith; Taylor, Mark B.; Teuben, Peter J.; Wallin, John F.

    2015-01-01

    The Astrophysics Source Code Library (ASCL, ascl.net) is a free online registry of codes used in astronomy research. Indexed by ADS, it now contains nearly 1,000 codes and with recent major changes, is better than ever! The resource has a new infrastructure that offers greater flexibility and functionality for users, including an easier submission process, better browsing, one-click author search, and an RSS feeder for news. The new database structure is easier to maintain and offers new possibilities for collaboration. Come see what we've done!

  2. Federal Pre-White House Conference on Library and Information Services Proceedings (Bethesda, Maryland, November 26-27, 1990).

    ERIC Educational Resources Information Center

    Federal Library and Information Center Committee, Washington, DC.

    This report presents the recommendations and proceedings of the Federal Pre-White House Conference on Library and Information Services (WHCLIS II) in two sections. Thirteen issues and recommendations of high national priority identified by the federal delegates to the WHCLIS II are provided in the first section: (1) Preservation Plan for Federal…

  3. Library Association of Australia, Proceedings Biennial Conference (15th, Adelaide, 25th-29th August, 1969).

    ERIC Educational Resources Information Center

    Library Association of Australia, Sidney.

    The fifteenth biennial Conference of the Library Association of Australia was held from August 25th to 29th, 1969, in Adelaide. This proceedings volume contains many of the papers given, and summaries of many others. Five papers were presented during the plenary sessions. Thirty-one authors presented general papers. There were nine seminars…

  4. Proceedings of the Northumbria International Conference on Performance Measurement in Libraries and Information Services: "Meaningful Measures for Emerging Realities" (4th, Pittsburgh, Pennsylvania, August 12-16, 2001).

    ERIC Educational Resources Information Center

    Stein, Joan, Ed.; Kyrillidou, Martha, Ed.; Davis, Denise, Ed.

    This Fourth Northumbria International Conference on Performance Measurement in Libraries and Information Services centered on the theme of "meaningful measures for emerging realities" and contributors surveyed the field of performance measurement from that perspective. The proceedings begins with seven keynote and invited papers from…

  5. 3rd Annual PIALA Conference Saipan--Collecting, Preserving & Sharing Information in Micronesia. Conference Proceedings. October 13-15, 1993.

    ERIC Educational Resources Information Center

    Edmundson, Margaret, Ed.

    1993-01-01

    This PIALA 1993 Proceedings contains many of the papers presented at the 3rd annual conference of the Pacific Islands Association of Libraries and Archives. This publication is the first time papers from this Micronesian regional library and archives conference have ever been published. The conference addressed various topics of interest to…

  6. IFLA Council and General Conference: Conference Programme and Proceedings (65th, Bangkok, Thailand, August 20-28, 1999).

    ERIC Educational Resources Information Center

    International Federation of Library Associations and Institutions, The Hague (Netherlands).

    This proceedings of the 1999 IFLA (International Federation of Library Associations and Institutions) annual conference contains: information on the current, future, and past conferences; a message from H.R.H. Princess Maha Chakri Sirindhorn, the patron of the Thai Library Association; a conference program; an alphabetical list of authors; and 112…

  7. 76 FR 60013 - Combined Notice of Filings #1

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-28

    ... per 35.17(b): Amendment--docket number inserted 09192011 to be effective 10/11/2011. Filed Date: 09/19... Northeast LLC submits tariff filing per 35.17(b): Amendment--docket number inserted 09192011 to be effective... Commission's eLibrary system by clicking on the links or querying the docket number. Any person desiring to...

  8. 78 FR 53746 - Combined Notice of Filings #1

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-30

    ...-72-002. Applicants: Dominion Energy Marketing, Inc. Description: Compliance Filing of Dominion Energy Marketing, Inc. Filed Date: 8/16/13. Accession Number: 20130816-5208. Comments Due: 5 p.m. ET 9/6/13. Docket... accessible in the Commission's eLibrary system by clicking on the links or querying the docket number. Any...

  9. 78 FR 52522 - Combined Notice of Filings #1

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-23

    ... Applicants: PJM Interconnection, L.L.C. Description: Queue No. W2-014; First Revised Service Agreement No... the Commission's eLibrary system by clicking on the links or querying the docket number. Any person... 214 of the Commission's Regulations (18 CFR 385.211 and 385.214) on or before 5:00 p.m. Eastern time...

  10. 36 CFR § 703.19 - Requests for authenticated copies of Library documents.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... copies of Library documents. § 703.19 Section § 703.19 Parks, Forests, and Public Property LIBRARY OF... Documents in Certain Legal Proceedings Where the Library Is Not a Party § 703.19 Requests for authenticated copies of Library documents. Requests for authenticated copies of Library documents for purposes of...

  11. 36 CFR § 703.22 - Where to serve demands.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ....22 Section § 703.22 Parks, Forests, and Public Property LIBRARY OF CONGRESS DISCLOSURE OR PRODUCTION... Proceedings Where the Library Is Not a Party § 703.22 Where to serve demands. Requesting parties must serve..., Library of Congress, Washington, DC 20540. (b) For Law Library matters: Law Librarian, LM 240, Library of...

  12. Academic Libraries: Achieving Excellence in Higher Education. Proceedings of the National Conference of the Association of College and Research Libraries (6th, Salt Lake City, Utah, April 12-14, 1992).

    ERIC Educational Resources Information Center

    Kirk, Thomas, Ed.

    These proceedings begin with four theme papers on civil rights, information technologies, the Information Society, and measures of success. Fifty-two contributed papers are then organized into seven broad subject areas: (1) academic librarianship (stereotypes of librarians, minority leadership, collegial leadership, curriculum reform, library…

  13. International Library Cooperation. Essen Symposium (10th, Essen, West Germany, October 19-22, 1987).

    ERIC Educational Resources Information Center

    Helal, Ahmed H., Ed.; Weiss, Joachim W., Ed.

    The proceedings of this symposium contain the texts of 21 presentations: (1) "The Alexandriana Library: A New Opportunity in International Library Cooperation" (Stuart Ede); (2) "Conservation, Culture and Curriculum" (Brendan Loughridge); (3) "European Library Cooperation: An EC (European Community) Standpoint"…

  14. One-pot synthesis of keto thioethers by palladium/gold-catalyzed click and pinacol reactions.

    PubMed

    Cadu, Alban; Watile, Rahul A; Biswas, Srijit; Orthaber, Andreas; Sjöberg, Per J R; Samec, Joseph S M

    2014-11-07

    An atom-efficient synthesis of keto thioethers was devised via tandem gold/palladium catalysis. The reaction proceeds through a regioselective thiol attack at the β-position of the alcohol, followed by an alkyl, aryl, or benzyl 1,2-shift. Both acyclic and cyclic systems were studied, in the latter case leading to the ring expansion of cyclic substrates.

  15. The White House Conference on School Libraries Proceedings (Washington, DC, June 4, 2002).

    ERIC Educational Resources Information Center

    Institute of Museum and Library Services, Washington, DC.

    Laura Bush hosted a White House Conference on School Libraries on June 4, 2002, to discuss the latest research on libraries, student achievement and successful local programs. Mrs. Bush's cohost was Dr. Robert Martin, Director of the Institute of Museum and Library Services and education, library, government and philanthropic leaders from across…

  16. Library History Seminar No. 3, Proceedings, 1968.

    ERIC Educational Resources Information Center

    Zachert, Martha Jane, Ed.

    Included in this book are 12 papers: (1) "The Newberry Library: A Research Opportunity in Library History," by Lawrence W. Towner; (2) "Society's Contradictions and the Library: Notes on Some Negative Effects of Humanism," by Sidney L. Jackson; (3) "The Acquisition of the Van Ess Library by Union Theological Seminary in the City of New York," by…

  17. 76 FR 59674 - Combined Notice of Filings #1

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-27

    ..., October 06, 2011. Docket Numbers: ER11-4530-000. Applicants: Dynamic PL, LLC. Description: Dynamic PL, LLC submits tariff filing per 35.1: Dynamic PL, LLC Re-file to be effective 9/15/2011. Filed Date: 09/15/2011... Thursday, October 06, 2011. The filings are accessible in the Commission's eLibrary system by clicking on...

  18. 75 FR 14592 - Dynamic PL, Inc.; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-26

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER10-853-000] Dynamic PL... Dynamic PL, Inc's application for market-based rate authority, with an accompanying rate tariff, noting... accessible in the Commission's eLibrary system by clicking on the appropriate link in the above list. They...

  19. 76 FR 55373 - Combined Notice of Filings #1

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-07

    ....13(a)(2)(iii: PJM Queue Position W2-075--Original Service Agreement No. 3039 to be effective 7/28... the Commission's eLibrary system by clicking on the links or querying the docket number. Any person... 214 of the Commission's Regulations (18 CFR 385.211 and 385.214) on or before 5 p.m. Eastern time on...

  20. 76 FR 51964 - Combined Notice of Filings # 1

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-19

    ...'s to be effective 10/9/2011. Filed Date: 08/10/2011. Accession Number: 20110810-5048. Comment Date... Queue No. P59/W2-057; Original Service Agreement No. 2987 to be effective 7/12/2011. Filed Date: 08/10.... The filings are accessible in the Commission's eLibrary system by clicking on the links or querying...

  1. VTLS Proceedings.

    ERIC Educational Resources Information Center

    Scheid, Barbara; And Others

    1996-01-01

    Includes five papers presented at the 1995 VTLS Inc. Fifth Annual Director's Conference in Roanoke (Virginia), entitled "Back to Basics: Rethinking Libraries." Topics include libraries' use of high technology, collection management and electronic publishing, public services and telecommuting clientele, what to expect of library school…

  2. Government's Role in the Electronic Era: User Needs and Government's Response, Proceedings of the Annual FLICC Forum on Federal Information Policies (10th, Washington, D.C., March 25, 1993).

    ERIC Educational Resources Information Center

    Mulford, Carolyn

    This proceedings of the annual forum of the Federal Library and Information Center committee (FLICC) of the Library of Congress begins with summaries of introductory and special remarks, two keynote addresses, 15 presentations, and the comments they generated. The publication also contains the text of the keynote addresses: "Establishing a…

  3. Triazolophostins: a library of novel and potent agonists of IP3 receptors† †Electronic supplementary information (ESI) available: Synthetic procedures and spectral data for all new compounds, crystal data for disaccharide 4 and details of the docking study. CCDC 1022279. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c5ob00440c Click here for additional data file. Click here for additional data file.

    PubMed Central

    Vibhute, Amol M.; Konieczny, Vera; Taylor, Colin W.

    2015-01-01

    IP3 receptors are channels that mediate the release of Ca2+ from the intracellular stores of cells stimulated by hormones or neurotransmitters. Adenophostin A (AdA) is the most potent agonist of IP3 receptors, with the β-anomeric adenine contributing to the increased potency. The potency of AdA and its stability towards the enzymes that degrade IP3 have aroused interest in AdA analogs for biological studies. The complex structure of AdA poses problems that have necessitated optimization of synthetic conditions for each analog. Such lengthy one-at-a-time syntheses limit access to AdA analogs. We have addressed this problem by synthesizing a library of triazole-based AdA analogs, triazolophostins, by employing click chemistry. An advanced intermediate having all the necessary phosphates and a β-azide at the anomeric position was reacted with various alkynes under Cu(i) catalysis to yield triazoles, which upon deprotection gave triazolophostins. All eleven triazolophostins synthesized are more potent than IP3 and some are equipotent with AdA in functional analyses of IP3 receptors. We show that a triazole ring can replace adenine without compromising the potency of AdA and provide facile routes to novel AdA analogs. PMID:25869535

  4. Proceedings of the Conference on Machine-Readable Catalog Copy (3rd, Library of Congress, February 25, 1966).

    ERIC Educational Resources Information Center

    Library of Congress, Washington, DC.

    A conference was held to permit a discussion between the libraries that will participate in the Library of Congress machine-readable cataloging (MARC) pilot project. The MARC pilot will provide an opportunity for the Library of Congress to assess the effect which data conversion places on the Library's normal processing procedures; the suitability…

  5. Libraries and the Literacy Challenge: The Frontier of the 90's. Proceedings of the Mountain Plains Library Association Academic Library Section Research Forum (Bismarck, North Dakota, September 23-26, 1987).

    ERIC Educational Resources Information Center

    Hatfield, V. Sue, Ed.

    The following papers were presented at a joint conference of the Mountain Plains Library Association, the North Dakota Library Association, and the South Dakota Library Association in September 1987: (1) "Catalog Backlog Project" (Kay Juricek, Tedine Roos, and Carol White); (2) "How Are We Doing? Using a Materials Availability…

  6. Government Information: An Endangered Resource of the Electronic Age. Proceedings of the Annual State-of-the-Art Institute (1st, Washington, DC, October 19-22, 1986).

    ERIC Educational Resources Information Center

    Special Libraries Association, Washington, DC.

    These proceedings contain edited versions of 14 papers on government information and its relation to the library and information community that were presented at a state-of-the-art institute sponsored by the Special Library Association (SLA). Following a foreword by Steve Bell of ABC News and an introduction by David R. Bender of the SLA, papers…

  7. 36 CFR 703.20 - File copies.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 703.20 Parks, Forests, and Public Property LIBRARY OF CONGRESS DISCLOSURE OR PRODUCTION OF RECORDS OR INFORMATION Testimony by Employees and Production of Documents in Certain Legal Proceedings Where the Library... file of copies of all demands served on the Library and deciding officials' responses. ...

  8. 36 CFR 703.20 - File copies.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 703.20 Parks, Forests, and Public Property LIBRARY OF CONGRESS DISCLOSURE OR PRODUCTION OF RECORDS OR INFORMATION Testimony by Employees and Production of Documents in Certain Legal Proceedings Where the Library... file of copies of all demands served on the Library and deciding officials' responses. ...

  9. 36 CFR 703.20 - File copies.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 703.20 Parks, Forests, and Public Property LIBRARY OF CONGRESS DISCLOSURE OR PRODUCTION OF RECORDS OR INFORMATION Testimony by Employees and Production of Documents in Certain Legal Proceedings Where the Library... file of copies of all demands served on the Library and deciding officials' responses. ...

  10. 37 CFR 351.1 - Initiation of proceedings.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... the distribution of royalty fees, shall be initiated by publication in the Federal Register of a.... 351.1 Section 351.1 Patents, Trademarks, and Copyrights COPYRIGHT ROYALTY BOARD, LIBRARY OF CONGRESS COPYRIGHT ROYALTY JUDGES RULES AND PROCEDURES PROCEEDINGS § 351.1 Initiation of proceedings. (a) Notice of...

  11. 78 FR 25432 - Sabine Pass LNG, L.P., Sabine Pass Liquefaction, LLC; Notice of Availability of the Environmental...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-01

    ... Affairs, at (866) 208-FERC, or on the FERC Web site ( www.ferc.gov ) using the eLibrary link. Click on the... heavies removal column, a heavies removal column reboiler, a debutanizer system, and a condensate stabilizer system to be located inside the battery limits within each of the four liquefaction trains; two...

  12. Besides Google: Guiding Gifted Elementary Students onto the Entrance Ramp of the Information Superhighway

    ERIC Educational Resources Information Center

    Schneider, Joan

    2009-01-01

    For gifted students, the power of the Internet is its vastness. Students can access extensive resources that far exceed the collections in their classrooms or school library. Especially with the rapid growth of the Internet during the last decade, the gateway to a rich array of sophisticated resources is literally a click away. Curriculum content…

  13. 75 FR 69425 - Qualified Hydro 30, LLC; Notice of Preliminary Permit Application Accepted for Filing and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-12

    ... vertical Kaplan turbine-generator units with a combined capacity of 2.5 megawatts; (5) a new 3-MVA.../ferconline.asp ) under the ``eFiling'' link. For a simpler method of submitting text only comments, click on... this project, including a copy of the application can be viewed or printed on the ``eLibrary'' link of...

  14. 75 FR 70224 - Qualified Hydro 29, LLC; Notice of Preliminary Permit Application Accepted for Filing and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-17

    ...-foot diameter penstock; (4) two vertical Kaplan turbine-generator units with a combined capacity of 7.0... ) under the ``eFiling'' link. For a simpler method of submitting text only comments, click on ``Quick... project, including a copy of the application can be viewed or printed on the ``eLibrary'' link of...

  15. 75 FR 69426 - Qualified Hydro 31, LLC; Notice of Preliminary Permit Application Accepted for Filing and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-12

    ... penstock; (4) two vertical Kaplan turbine- generator units with a combined capacity of 3.5 megawatts; (5) a.../ferconline.asp ) under the ``eFiling'' link. For a simpler method of submitting text only comments, click on... this project, including a copy of the application can be viewed or printed on the ``eLibrary'' link of...

  16. 78 FR 8505 - Combined Notice of Filings #2

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-06

    ... tariff filing per 35.13(a)(2)(iii: Original Service Agreement No. 3485; Queue No. W2-039 to be effective... in the Commission's eLibrary system by clicking on the links or querying the docket number. Any... Rules 211 and 214 of the Commission's Regulations (18 CFR 385.211 and 385.214) on or before 5:00 p.m...

  17. 77 FR 33207 - Combined Notice of Filings #1

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-05

    ...; Queue No. W2-090 to be effective 5/1/2011. Filed Date: 5/23/12. Accession Number: 20120523-5073... accessible in the Commission's eLibrary system by clicking on the links or querying the docket number. Any... Rules 211 and 214 of the Commission's Regulations (18 CFR 385.211 and 385.214) on or before 5:00 p.m...

  18. NOAA Photo Library - Navigating the Collection

    Science.gov Websites

    will have to change the setting to 800x600 to view the full image without having to scroll from left to view or download the highest resolution image available, click on the message "High Resolution viewing individual images associated with albums. If wishing to view the image ID number of a thumbnail

  19. Towards a Worldwide Library: A Ten Year Forecast. Proceedings of the International Essen Symposium (19th, Essen, Germany, September 23-26, 1996). Publications of Essen University Library, No. 21.

    ERIC Educational Resources Information Center

    Helal, Ahmed H., Ed.; Weiss, Joachim W., Ed.

    The 25 papers presented at this symposium focus on the future of libraries and library services in an ever evolving Information Age. The papers deal with topics such as: economic and political issues in determining the future of the professionally managed library; adding value to library services; the need for librarians and library educators who…

  20. Identification of highly selective and potent histone deacetylase 3 inhibitors using click chemistry-based combinatorial fragment assembly.

    PubMed

    Suzuki, Takayoshi; Kasuya, Yuki; Itoh, Yukihiro; Ota, Yosuke; Zhan, Peng; Asamitsu, Kaori; Nakagawa, Hidehiko; Okamoto, Takashi; Miyata, Naoki

    2013-01-01

    To find histone deacetylase 3 (HDAC3)-selective inhibitors, a series of 504 candidates was assembled using "click chemistry", by reacting nine alkynes bearing a zinc-binding group with 56 azide building blocks in the presence of Cu(I) catalyst. Screening of the 504-member triazole library against HDAC3 and other HDAC isozymes led to the identification of potent and selective HDAC3 inhibitors T247 and T326. These compounds showed potent HDAC3 inhibition with submicromolar IC50s, whereas they did not strongly inhibit other isozymes. Compounds T247 and T326 also induced a dose-dependent selective increase of NF-κB acetylation in human colon cancer HCT116 cells, indicating selective inhibition of HDAC3 in the cells. In addition, these HDAC3-selective inhibitors induced growth inhibition of cancer cells, and activated HIV gene expression in latent HIV-infected cells. These findings indicate that HDAC3-selective inhibitors are promising candidates for anticancer drugs and antiviral agents. This work also suggests the usefulness of the click chemistry approach to find isozyme-selective HDAC inhibitors.

  1. 37 CFR 351.5 - Discovery in royalty rate proceedings.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... proceedings. 351.5 Section 351.5 Patents, Trademarks, and Copyrights COPYRIGHT ROYALTY BOARD, LIBRARY OF... matter, not privileged, that is relevant to the claim or defense of any party. Relevant information need... information and materials. (1) In any royalty rate proceeding scheduled to commence prior to January 1, 2011...

  2. Proceedings from the 1982 Spring Meeting of the Nebraska Library Association, College and University Section (Seward, Nebraska, April 15-16, 1982).

    ERIC Educational Resources Information Center

    Franco, Elaine A., Ed.

    The papers presented at the 1982 Spring Meeting of the Nebraska Library Association include: (1) "Online Catalog Cooperation among LIRS [Library Information Retrieval System] Libraries" by Roxanne Sellberg; (2) "The New 'MLA Bibliography': One Bibliographer's Perspective" by Elaine A. Franco; (3) "Serial Cancellation…

  3. Automated Docking with Protein Flexibility in the Design of Femtomolar “Click Chemistry” Inhibitors of Acetylcholinesterase

    PubMed Central

    Morris, Garrett M.; Green, Luke G.; Radić, Zoran; Taylor, Palmer; Sharpless, K. Barry; Olson, Arthur J.; Grynszpan, Flavio

    2013-01-01

    The use of computer-aided structure-based drug design prior to synthesis has proven to be generally valuable in suggesting improved binding analogues of existing ligands.1 Here we describe the application of the program AutoDock2 to the design of a focused library that was used in the “click chemistry in-situ” generation of the most potent non-covalent inhibitor of the enzyme acetylcholinesterase (AChE) yet developed (Kd = ~100 fM).3 AutoDock version 3.0.5 has been widely distributed and successfully used to predict bound conformations of flexible ligands. Here, we also used a version of AutoDock which permits additional conformational flexibility in selected amino acid sidechains of the target protein. PMID:23451944

  4. 75 FR 52527 - The Trustees of the University of Pennsylvania; Supplemental Notice That Initial Market-Based...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-26

    ... of the University of Pennsylvania; Supplemental Notice That Initial Market-Based Rate Filing Includes...-referenced proceeding, of The Trustees of the University of Pennsylvania's application for market-based rate.... The filings in the above-referenced proceeding(s) are accessible in the Commission's eLibrary system...

  5. Stanford Conference on Collaborative Library Systems Development. Proceedings of a Conference Held at Stanford University Libraries, October 4-5, 1968.

    ERIC Educational Resources Information Center

    Veaner, Allen B., Ed.; Fasana, Paul J., Ed.

    The conference was convened (1) to disseminate information on the development of Stanford's library automation project, and (2) to disseminate information on the several and joint library automation activities of Chicago, Columbia, and Stanford, and (3) to promote heated discussion and active exchange of ideas and problems between librarians,…

  6. User Education in the Online Age II. IATUL International Seminar Proceedings, (2nd, Delft, The Netherlands, July 30-August 2, 1984). Vol. 17.

    ERIC Educational Resources Information Center

    Fjallbrant, Nancy, Ed.

    1985-01-01

    Papers presented at an August 1984 international seminar on online user education include "Library Policies and Strategies in The Netherlands" (Chris J. van Wijk, The Netherlands); "Promotion and Marketing of Library Services" (Nancy Fjallbrant, Sweden); "Library Promotion by Computer" (Ian Malley, United Kingdom); "Library User Education and…

  7. 78 FR 2982 - Northwest Pipeline GP; Notice of Availability of the Environmental Assessment for the Proposed...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-15

    ... consider your comments prior to making its decision on this project, it is important that we receive your... for public viewing on the FERC's Web site ( www.ferc.gov ) using the eLibrary link. A limited number... first create an account by clicking on ``eRegister.'' You must select the type of filing you are making...

  8. The Information Economy in the U.S.: Its Effect on Libraries and Library Networks. Proceedings of the Library of Congress Network Advisory Committee Meeting (Washington, D.C., November 14-16, 1984). Network Planning Paper No. 10.

    ERIC Educational Resources Information Center

    Library of Congress, Washington, DC. Network Development Office.

    At a 2-day meeting in November 1984, the Library of Congress Network Advisory Committee (NAC) discussed the information economy in the United States and its effect on libraries and library networks. Material presented at the meeting is included in the form of summaries of three papers on the program theme presented by Ronald F. Miller, Kenneth W.…

  9. 37 CFR 251.61 - Commencement of adjustment proceedings.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... proceedings. 251.61 Section 251.61 Patents, Trademarks, and Copyrights COPYRIGHT OFFICE, LIBRARY OF CONGRESS... cable, ephemeral recordings, certain digital audio transmissions, phonorecords, digital phonorecord... the parties. (3) Digital audio transmissions: For preexisting digital subscription transmission...

  10. 37 CFR 251.61 - Commencement of adjustment proceedings.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... proceedings. 251.61 Section 251.61 Patents, Trademarks, and Copyrights COPYRIGHT OFFICE, LIBRARY OF CONGRESS... cable, ephemeral recordings, certain digital audio transmissions, phonorecords, digital phonorecord... the parties. (3) Digital audio transmissions: For preexisting digital subscription transmission...

  11. IOLS '98. Proceedings of the National Conference on Integrated Online Library Systems (13th, New York, New York, May 13-14, 1998).

    ERIC Educational Resources Information Center

    Cibbarelli, Pamela R., Comp.; Nixon, Carol, Comp.

    Integrated Online Library Systems (IOLS) focuses exclusively on the issues of planning and managing automated systems in libraries and information centers. The theme of the IOLS '98 annual meeting is "Embrace and Extend," and 18 papers were selected for presentation that provide insight into the current technologies being "embraced" in libraries.…

  12. A Colorado Response to the Information Society: The Changing Academic Library. Proceedings of a Conference (Denver, Colorado, October 6-7, 1983).

    ERIC Educational Resources Information Center

    Breivik, Patricia Senn, Ed.

    As suggested by a Colorado Academic Library Master Plan developed in 1982, a statewide conference that brought together academicians and librarians was held to explore the role of academic libraries in the information society. People came in teams of three from institutions and included library directors, academic vice presidents, and faculty…

  13. Clinic on Library Applications of Data Processing, 1972. Proceedings: Applications of On-Line Computers to Library Problems.

    ERIC Educational Resources Information Center

    Lancaster, F. Wilfrid, Ed.

    In planning this ninth annual clinic an attempt was made to include papers on a wide range of library applications of on-line computers, as well as to include libraries of various types and various sizes. Two papers deal with on-line circulation control (the Ohio State University system, described by Hugh C. Atkinson, and the Northwestern…

  14. 36 CFR 703.15 - Purpose and scope of this subpart.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Proceedings Where the Library Is Not a Party § 703.15 Purpose and scope of this subpart. This subpart sets forth the policy and procedures of the Library of Congress regarding, first, the testimony, as witnesses... subpart. 703.15 Section 703.15 Parks, Forests, and Public Property LIBRARY OF CONGRESS DISCLOSURE OR...

  15. 36 CFR 703.15 - Purpose and scope of this subpart.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... subpart. 703.15 Section 703.15 Parks, Forests, and Public Property LIBRARY OF CONGRESS DISCLOSURE OR... Proceedings Where the Library Is Not a Party § 703.15 Purpose and scope of this subpart. This subpart sets forth the policy and procedures of the Library of Congress regarding, first, the testimony, as witnesses...

  16. 36 CFR 703.15 - Purpose and scope of this subpart.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... subpart. 703.15 Section 703.15 Parks, Forests, and Public Property LIBRARY OF CONGRESS DISCLOSURE OR... Proceedings Where the Library Is Not a Party § 703.15 Purpose and scope of this subpart. This subpart sets forth the policy and procedures of the Library of Congress regarding, first, the testimony, as witnesses...

  17. 36 CFR 703.15 - Purpose and scope of this subpart.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... subpart. 703.15 Section 703.15 Parks, Forests, and Public Property LIBRARY OF CONGRESS DISCLOSURE OR... Proceedings Where the Library Is Not a Party § 703.15 Purpose and scope of this subpart. This subpart sets forth the policy and procedures of the Library of Congress regarding, first, the testimony, as witnesses...

  18. Versatile telluracycle synthesis via the sequential electrophilic telluration of C(sp2)–Zn and C(sp2)–H bonds† †Electronic supplementary information (ESI) available. CCDC 1523262–1523264. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c7sc01162h Click here for additional data file. Click here for additional data file.

    PubMed Central

    Wu, Bin; Melvina; Wu, Xiangyang; Lee Yeow, Edwin Kok

    2017-01-01

    We report herein a new approach for the synthesis of tellurium-bridged aromatic compounds based on the sequential electrophilic telluration of C(sp2)–Zn and C(sp2)–H bonds with tellurium(iv) chlorides. A combination of transition metal-catalyzed (migratory) arylmetalation of alkynes and sequential telluration allows for the expedient construction of a library of functionalized benzo[b]tellurophenes. Furthermore, a variety of heteroarene-fused benzotellurophenes and other novel tellurium-embedded polycyclic aromatics can be readily synthesized from the corresponding 2-iodoheterobiaryls. PMID:28970880

  19. ZINClick: a database of 16 million novel, patentable, and readily synthesizable 1,4-disubstituted triazoles.

    PubMed

    Massarotti, Alberto; Brunco, Angelo; Sorba, Giovanni; Tron, Gian Cesare

    2014-02-24

    Since Professors Sharpless, Finn, and Kolb first introduced the concept of "click reactions" in 2001 as powerful tools in drug discovery, 1,4-disubstituted-1,2,3-triazoles have become important in medicinal chemistry due to the simultaneous discovery by Sharpless, Fokin, and Meldal of a perfect click 1,3-dipolar cycloaddition reaction between azides and alkynes catalyzed by copper salts. Because of their chemical features, these triazoles are proposed to be aggressive pharmacophores that participate in drug-receptor interactions while maintaining an excellent chemical and metabolic profile. Surprisingly, no virtual libraries of 1,4-disubstituted-1,2,3-triazoles have been generated for the systematic investigation of the click-chemical space. In this manuscript, a database of triazoles called ZINClick is generated from literature-reported alkynes and azides that can be synthesized within three steps from commercially available products. This combinatorial database contains over 16 million 1,4-disubstituted-1,2,3-triazoles that are easily synthesizable, new, and patentable! The structural diversity of ZINClick ( http://www.symech.it/ZINClick ) will be explored. ZINClick will also be compared to other available databases, and its application during the design of novel bioactive molecules containing triazole nuclei will be discussed.

  20. Information Technology on Screen: New Approaches in Viewdata, Teletext and Cable. Proceedings of the Joint One Day Seminar held by Aslib/Institute of Information Scientists/Library Association at the Polytechnic of the South Bank (November 8, 1982). LA Conference Proceedings Series in Library Automation: 2.

    ERIC Educational Resources Information Center

    Library Association, London (England).

    The most important developments now taking place or being planned are emphasized in this collection of eight papers on the emerging aspects of information technology. In addition to an introduction by Ric Foot and a keynote address by John Butcher, the specific papers are as follows: (1) "Telesoftware as Part of the Knowledge Network,"…

  1. 36 CFR 703.18 - Procedures when an employee's appearance is demanded or documents are demanded.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... LIBRARY OF CONGRESS DISCLOSURE OR PRODUCTION OF RECORDS OR INFORMATION Testimony by Employees and Production of Documents in Certain Legal Proceedings Where the Library Is Not a Party § 703.18 Procedures... is being, as the case may be, referred for the prompt consideration of the appropriate Library or...

  2. 36 CFR § 703.18 - Procedures when an employee's appearance is demanded or documents are demanded.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Property LIBRARY OF CONGRESS DISCLOSURE OR PRODUCTION OF RECORDS OR INFORMATION Testimony by Employees and Production of Documents in Certain Legal Proceedings Where the Library Is Not a Party § 703.18 Procedures... is being, as the case may be, referred for the prompt consideration of the appropriate Library or...

  3. 36 CFR 703.16 - Policy on presentation of testimony and production of documents.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... testimony and production of documents. 703.16 Section 703.16 Parks, Forests, and Public Property LIBRARY OF... Documents in Certain Legal Proceedings Where the Library Is Not a Party § 703.16 Policy on presentation of testimony and production of documents. No Library of Congress employee may provide testimony or produce...

  4. 36 CFR 703.16 - Policy on presentation of testimony and production of documents.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... testimony and production of documents. 703.16 Section 703.16 Parks, Forests, and Public Property LIBRARY OF... Documents in Certain Legal Proceedings Where the Library Is Not a Party § 703.16 Policy on presentation of testimony and production of documents. No Library of Congress employee may provide testimony or produce...

  5. 36 CFR 703.16 - Policy on presentation of testimony and production of documents.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... testimony and production of documents. 703.16 Section 703.16 Parks, Forests, and Public Property LIBRARY OF... Documents in Certain Legal Proceedings Where the Library Is Not a Party § 703.16 Policy on presentation of testimony and production of documents. No Library of Congress employee may provide testimony or produce...

  6. 36 CFR 703.18 - Procedures when an employee's appearance is demanded or documents are demanded.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... LIBRARY OF CONGRESS DISCLOSURE OR PRODUCTION OF RECORDS OR INFORMATION Testimony by Employees and Production of Documents in Certain Legal Proceedings Where the Library Is Not a Party § 703.18 Procedures... is being, as the case may be, referred for the prompt consideration of the appropriate Library or...

  7. 36 CFR 703.17 - Procedures when testimony and/or documents are demanded.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    .../or documents are demanded. 703.17 Section 703.17 Parks, Forests, and Public Property LIBRARY OF... Documents in Certain Legal Proceedings Where the Library Is Not a Party § 703.17 Procedures when testimony and/or documents are demanded. A demand for testimony and/or documents by a Library employee must be...

  8. 36 CFR 703.17 - Procedures when testimony and/or documents are demanded.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    .../or documents are demanded. 703.17 Section 703.17 Parks, Forests, and Public Property LIBRARY OF... Documents in Certain Legal Proceedings Where the Library Is Not a Party § 703.17 Procedures when testimony and/or documents are demanded. A demand for testimony and/or documents by a Library employee must be...

  9. 36 CFR § 703.16 - Policy on presentation of testimony and production of documents.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... LIBRARY OF CONGRESS DISCLOSURE OR PRODUCTION OF RECORDS OR INFORMATION Testimony by Employees and Production of Documents in Certain Legal Proceedings Where the Library Is Not a Party § 703.16 Policy on presentation of testimony and production of documents. No Library of Congress employee may provide testimony or...

  10. 36 CFR 703.17 - Procedures when testimony and/or documents are demanded.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    .../or documents are demanded. 703.17 Section 703.17 Parks, Forests, and Public Property LIBRARY OF... Documents in Certain Legal Proceedings Where the Library Is Not a Party § 703.17 Procedures when testimony and/or documents are demanded. A demand for testimony and/or documents by a Library employee must be...

  11. 36 CFR 703.18 - Procedures when an employee's appearance is demanded or documents are demanded.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... LIBRARY OF CONGRESS DISCLOSURE OR PRODUCTION OF RECORDS OR INFORMATION Testimony by Employees and Production of Documents in Certain Legal Proceedings Where the Library Is Not a Party § 703.18 Procedures... is being, as the case may be, referred for the prompt consideration of the appropriate Library or...

  12. Competencies for Librarians. Proceedings from the 1985 Spring Meeting of the Nebraska Library Association: College and University Section (Omaha, Nebraska, April 26, 1985).

    ERIC Educational Resources Information Center

    Krzywkowski, Valerie I., Ed.

    Based on the conference theme, "Competencies for Librarians," papers presented at the 1985 meeting of the association include: (1) "Planning a Library-Based Public Access Microcomputer Facility" (Suzanne Kehm); (2) "Processing and Circulating Microcomputer Software in the Academic Library: A Sharing Session" (Jan…

  13. Proceedings of the Annual Conference of the International Association of School LIbrarianship (19th, Umea, Sweden, July 8-12, 1990).

    ERIC Educational Resources Information Center

    International Association of School Librarianship, Kalamazoo, MI.

    This conference report contains 32 presented papers: "Talking Books for Children in Sweden in Libraries and Schools" (L. Bergman); "At-Risk Students: How Do School (Library) Systems Respond?" (G. R. Brown); "Providing School Library Services to Immigrant Populations" (K. W. Craver); "Bibliographic Aids for School…

  14. The White House Conference on Library and Information Services, 1979. Summary, March 1980.

    ERIC Educational Resources Information Center

    National Commission on Libraries and Information Science, Washington, DC.

    This report to the President of the United States presents a summary of the planning, proceedings, and resolutions of the White House Conference on Library and Information Services. Questions the delegates addressed to the conference included: Do libraries, the traditional storehouses of information and knowledge, have a place in this fast moving…

  15. Opportunity 2000: Understanding and Serving Users in an Electronic Library. Proceedings of the International Essen Symposium (15th, Essen, Germany, October 12-15, 1992) To Commemorate the 20th Anniversary of the Essen University Library. Publications of Essen University Library 15.

    ERIC Educational Resources Information Center

    Helal, Ahmed H., Ed.; Weiss, Joachim W., Ed.

    Following a prefatory tribute to distinguished librarian Herbert S. White, this publication includes the following papers, mainly focused on user needs and library services in the electronic library age: "Information Technology, Users, and Intermediaries in the 21st Century: Some Observations and Predictions" (Herbert S. White);…

  16. Establishment of a search library about benzylisoquinoline alkaloids based on selective separation on the binaphthyl column and standard analysis on C18 column.

    PubMed

    Liu, Qiaoxia; Zhou, Binbin; Wang, Xinliang; Ke, Yanxiong; Jin, Yu; Yin, Lihui; Liang, Xinmiao

    2012-12-01

    A search library about benzylisoquinoline alkaloids was established based on preparation of alkaloid fractions from Rhizoma coptidis, Cortex phellodendri, and Rhizoma corydalis. In this work, two alkaloid fractions from each herbal medicine were first prepared based on selective separation on the "click" binaphthyl column. And then these alkaloid fractions were analyzed on C18 column by liquid chromatography coupled with tandem mass spectrometry. Many structure-related compounds were included in these alkaloids fractions, which led to easy separation and good MS response in further work. Therefore, a search library of 52 benzylisoquinoline alkaloids was established, which included eight aporphine, 19 tetrahydroprotoberberine, two protopine, two benzyltetrahydroisoquinoline, and 21 protoberberine alkaloids. The information of the search library contained compound names, structures, retention times, accurate masses, fragmentation pathways of benzylisoquionline alkaloids, and their sources from three herbal medicines. Using such a library, the alkaloids, especially those trace and unknown components in some herbal medicine could be accurately and quickly identified. In addition, the distribution of benzylisoquinoline alkaloids in the herbal medicines could be also summarized by searching the source samples in the library. © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  17. The Future of Libraries in Human Communication: Abstracts and Fulltext Documents of Papers and Demos Given at the [International Association of Technological University Libraries] IATUL Conference (Chania, Greece, May 17-21, 1999). Volume 19.

    ERIC Educational Resources Information Center

    International Association of Technological Univ. Libraries, Gothenburg (Sweden).

    This proceedings of the IATUL 1999 conference of the contains the following papers: "From Industry to Higher Education and Libraries: Building the Fast Response Library" (A. S. Apostolou & C. H. Skiadas); "Managing the Learning Agenda in a Converged Service Environment" (Richard Biddiscombe); "Management of Electronic Information" (Michael…

  18. 37 CFR 251.21 - Public records.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ..., reports, and findings on any CARP matter or proceeding; (6) Communications among the Librarian of Congress and staff of the Copyright Office or Library of Congress concerning decisions, opinions, reports... Section 251.21 Patents, Trademarks, and Copyrights COPYRIGHT OFFICE, LIBRARY OF CONGRESS COPYRIGHT...

  19. Now That I Have It, What Can I Do with It?

    NASA Astrophysics Data System (ADS)

    Holmes, Jon L.

    1999-11-01

    All JCE subscribers now have access to all areas of JCE Online. As a reader of the print Journal you may be wondering what benefits JCE Online offers you and how you can reap those benefits. Point your WWW browser at jchemed.chem.wisc.edu, login, and follow along. Keep in mind that the three benefits outlined below are those that directly benefit you as a Journal reader. JCE Online contains many other resources that will benefit you as a chemistry teacher. Find an Article, Any Article The JCE Online feature that I perceive to be most beneficial to Journal readers is the ease and speed of finding articles. Finding a particular Journal article or several related articles is quickly and conveniently accomplished by using JCE Index online. Clicking the JCE Index item in the left-hand navigation bar leads to the JCE Index search page. A vanity search for articles that I authored or co-authored (type "holmes j" into the search text field and press Enter) produces a list of the ten most recent articles. A click on one of the articles and another click on the Full Text (.pdf) button (in the page menu bar near the top of the page below the global menu bar) and I am looking at one of my articles just as it appeared in the Journal. Four clicks, nine keystrokes, and 25 seconds (your time may vary)... not bad! Searching the Journal has never been easier than using the online JCE Index. If you remember which issue of the Journal contains the article you are looking for, then that article is never more than six mouse clicks away from the JCE Online Home Page. Of course, this only applies if we have the article online; full text articles begin with the September 1996 issue. The first click is on the Past Issues item in the left-hand navigation bar. If the article is not in the current volume of the Journal (your memory is much better than mine if you remember farther back) then the next click (click two) is on the pop-up list of Journal volumes from which you select the year the article appeared. After the correct volume is selected, use your next click to select the issue by clicking (click three) on one of the issue cover thumbnails. This brings you to the issue Table of Contents where you will probably have to scroll down to find the article (click four). Click the title of the article (click five) to go to the abstract of the article. Click six on the Full Text (.pdf) button in the page menu bar finishes the job. On my computer the six clicks from the JCE Online home page to the full text of an article by Jones et al., "Preparing Preservice Chemistry Teachers for Constructivist Classrooms through Use of Authentic Activities", in the July 1997 issue took 35 seconds including the time required to start up Acrobat Reader; a lot quicker than a trip to the chemistry library and easier even than a trip to the bookshelf across the room! A pop-up list is used to select a volume of the Journal from the Past Issues page. As I mentioned above, only issues since September 1996 have full-text articles available online. Abstracts of articles online go back to July 1995. JCE Index does contain citations to all articles published in the Journal back to Volume 1, Number 1more than 25,700 citations to date. When an online search produces an article that is not available online, you will have to retrieve it the old-fashioned way with a trip to the library or bookshelf. But at least you will know exactly where to look. Supplement Your Print Version You may have noticed a W near the title of some articles, especially laboratory experiments, in the Journal Table of Contents and within the Journal. This W denotes articles that contain online supplementary materials. Such materials are provided by the authors of those articles and may include handouts, assignments, worksheets, procedures, digital video, color illustrations, softwarematerials that you will find beneficial in implementing the idea or laboratory experiment. At JCE Online such articles contain a Supplement button in the page menu bar. For articles with supplementary materials, the Supplement button takes JCE subscribers to the supplement download page. Clicking the Supplement button produces the supplement download page. We attempt to provide supplementary materials as PDF files that are readily downloaded, viewed, and printed using Acrobat Reader. We also take the files in the format provided by the author, which you may find easier to edit for your purposes, and combine them into a single compressed file. This file is available in two forms, one for Windows users and one for Macintosh users. Click the Supplements item in the left-hand navigation bar to find out more about downloading and viewing supplemental materials and for a link to a list of all such materials available at JCE Online. Send Us Your Comments and Suggestions At the bottom of every page at JCE Online is a link to our email address. Do not hesitate to use it to tell us what you think about the Journal and JCE Online. We read all such messages and try to reply to every one. I hope you agree that JCE Online has something to offer you and look forward to hearing from you.

  20. 36 CFR § 703.15 - Purpose and scope of this subpart.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... subpart. § 703.15 Section § 703.15 Parks, Forests, and Public Property LIBRARY OF CONGRESS DISCLOSURE OR... Proceedings Where the Library Is Not a Party § 703.15 Purpose and scope of this subpart. This subpart sets forth the policy and procedures of the Library of Congress regarding, first, the testimony, as witnesses...

  1. 36 CFR § 703.17 - Procedures when testimony and/or documents are demanded.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    .../or documents are demanded. § 703.17 Section § 703.17 Parks, Forests, and Public Property LIBRARY OF... Documents in Certain Legal Proceedings Where the Library Is Not a Party § 703.17 Procedures when testimony and/or documents are demanded. A demand for testimony and/or documents by a Library employee must be...

  2. AccessAbility: Overcoming Information Barriers. Proceedings from the 1987 Spring Meeting of the Nebraska Library Association, College and University Section (Omaha, Nebraska, May 29, 1987).

    ERIC Educational Resources Information Center

    Kacena, Barbara J., Ed.

    Various aspects of the theme, "AccessAbility: Overcoming Information Barriers," are considered in the conference papers collected in this document. They include: (1) "The Library Image: A Barrier to Accessibility" (Janice S. Boyer); (2) "The Educationally Disadvantaged Student: How Can the Library Help?" (Michael Poma…

  3. Information Literacy and Digital Literacy: Competing or Complementary?

    ERIC Educational Resources Information Center

    Cordell, Rosanne Marie

    2013-01-01

    Digital literacy is a more recent concept than information literacy and can relate to multiple categories of library users in multiple types of libraries. Determining the relationship between information literacy and digital literacy is essential before revision of the ACRL "Standards" can proceed.

  4. Interlending and Document Delivery. IATUL Proceedings, Vol. 16.

    ERIC Educational Resources Information Center

    Fjallbrant, Nancy, Ed.

    1984-01-01

    This issue of the IATUL (International Association of Technological University Libraries) Proceedings provides an overview of interlending and document delivery in a number of countries. The document comprises: (1) "Interlibrary Lending in the United Kingdom" (Maurice B. Line); (2) "Interlending and Document Delivery in the Federal…

  5. 37 CFR 251.73 - Deduction of costs of distribution proceedings.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... OF CONGRESS COPYRIGHT ARBITRATION ROYALTY PANEL RULES AND PROCEDURES COPYRIGHT ARBITRATION ROYALTY PANEL RULES OF PROCEDURE Royalty Fee Distribution Proceedings § 251.73 Deduction of costs of... distributions of royalty fees are made, deduct the reasonable costs incurred by the Library of Congress and the...

  6. Information Management. VALA National Conference on Library Automation Proceedings (2nd, Melbourne, Australia, November 28-December 1, 1983). Volume 1.

    ERIC Educational Resources Information Center

    Cheney, B. J., Ed.

    The first of two volumes of a conference proceedings, this document contains the welcome, the opening, the keynote addresses, and the invited papers, as well as a submitted paper by John Gillam which was not available for publication in the pre-prints (Volume 2) prior to the conference. Three addresses are not included in these proceedings and…

  7. Reclassification: Rationale and Problems; Proceedings of a Conference on Reclassification held at the Center of Adult Education, University of Maryland, College Park, April 4 to 6, 1968.

    ERIC Educational Resources Information Center

    Perreault, Jean M., Ed.

    Several factors are involved in the decision to reclassify library collections and several problems and choices must be faced. The discussion of four classification schemes (Dewey Decimal, Library of Congress, Library of Congress subject-headings and Universal Decimal Classification) involved in the choices concerns their structure, currency,…

  8. Redefining Higher Education. Proceedings of the Meeting of the Association of Research Libraries (129th, Washington, DC, October 16-18, 1996).

    ERIC Educational Resources Information Center

    Barrett, Jaia, Ed.; Wetzel, Karen A., Ed.

    The 129th meeting of the Association of Research Libraries (ARL) focused on anticipating the future of higher education in North America and identifying responses from research libraries that will contribute to emerging agendas for change. An opening session (convened by Nancy Cline, ARL Presiding President) began the meeting. The first session,…

  9. The Library Environment, Aspects of Interior Planning. Proceedings of the Library Equipment Institute (St. Louis, Missouri, June 26-27, 1964).

    ERIC Educational Resources Information Center

    Poole, Frazer G., Ed.

    The texts of the papers given at the Library Equipment Institute, as well as the presentations of the panelists and the discussions between members of the audience and the program speakers, are included. Diagrams and other illustrative materials accompany the text. Specific topics include--(1) furnishings, (2) illumination, (3) audio, (4)…

  10. Conference on Sharing Caribbean Resources for Instruction and Research, College of the Virgin Islands, March 17-19, 1969. Proceedings.

    ERIC Educational Resources Information Center

    College of the Virgin Islands, St. Thomas.

    The first day of the conference identified library resources, what they are and where they are, whether in the area or outside of it. The second was devoted to discussing access to these resources, the problem encountered in gaining access to them, identification of library needs and ways to make library efforts more successful. Recommendations of…

  11. Renewing the ARL Agenda. Proceedings of the Annual Meeting of the Association of Research Libraries (125th, Washington, DC, October 19-21, 1994).

    ERIC Educational Resources Information Center

    Page, Jennifer, Ed.; Brennan, Patricia, Ed.

    The 125th meeting of the Association of Research Libraries (ARL) reviewed the mission statement, goals, and objectives of the Association. Major themes from the review process included the effect of technology on access and preservation; the critical need to develop measures of library effectiveness and performance; and the importance of…

  12. Internet and Advertisement.

    PubMed

    Moustafa, Khaled

    2016-02-01

    The Internet has revolutionized the way knowledge is currently produced, stored and disseminated. A few finger clicks on a keyboard can save time and many hours of search in libraries or shopping in stores. Online trademarks with an (e-) prefix such as e-library, e-business, e-health etc., are increasingly part of our daily professional vocabularies. However, the Internet has also produced multiple negative side effects, ranging from an unhealthy dependency to a dehumanization of human relationships. Fraudulent, unethical and scam practices are also flourishing through for example misleading online advertising methods. Some social and professional networks gather users' profiles for selling and advertising purposes, sometimes by making it technically difficult to unsubscribe. Here, I discuss some of these unethical aspects and propose some potential solutions to reduce them.

  13. Proceedings of the College Reading Association, Volume 5, Fall 1964.

    ERIC Educational Resources Information Center

    Ketcham, Clay A., Ed.

    The proceedings of the seventh annual meeting of the College Reading Association consisted of the following papers: (1) "President's Report" (Martha J. Maxwell); (2) "The Library Is Your Reading Test" (Nancy Larrick); (3) "The Lehigh--Bethlehem ITA Study Interim Report Four" (Albert J. Mazurkiewicz); (4) "The…

  14. The Challenge To Be Relevant in the 21st Century: Abstracts and Full Text Documents of Papers and Demos Given at the [International Association of Technological University Libraries] IATUL Conference (Pretoria, South Africa, June 1-5, 1998), Volume 18.

    ERIC Educational Resources Information Center

    International Association of Technological Univ. Libraries, Gothenburg (Sweden).

    This proceedings of the 1998 conference of the International Association of Technological University Libraries (IATUL) contains the full text of the following papers: "A Library Ready for 21st Century Services: The Case of the University of Science and Technology (UST) Library, Kumasi, Ghana" (Helena Rebecca Asamoah-Hassan);…

  15. 7 CFR 2.31 - General Counsel.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Patent Office. (f) Represent the Department in formal rulemaking and adjudicatory proceedings held in... 7 Agriculture 1 2011-01-01 2011-01-01 false General Counsel. 2.31 Section 2.31 Agriculture Office... the Law Library, furnishing complete legal and legislative library services to the Office of the...

  16. 7 CFR 2.31 - General Counsel.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Patent Office. (f) Represent the Department in formal rulemaking and adjudicatory proceedings held in... 7 Agriculture 1 2013-01-01 2013-01-01 false General Counsel. 2.31 Section 2.31 Agriculture Office... the Law Library, furnishing complete legal and legislative library services to the Office of the...

  17. 7 CFR 2.31 - General Counsel.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Patent Office. (f) Represent the Department in formal rulemaking and adjudicatory proceedings held in... 7 Agriculture 1 2012-01-01 2012-01-01 false General Counsel. 2.31 Section 2.31 Agriculture Office... the Law Library, furnishing complete legal and legislative library services to the Office of the...

  18. "Computers: Cure-All or Snake Oil?" Proceedings from the Spring Meeting of the Nebraska Library Association, College and University Section (Bellevue, Nebraska, April 20, 1984).

    ERIC Educational Resources Information Center

    Krzywkowski, Valerie I., Ed.

    The 15 papers in this collection discuss various aspects of computer use in libraries and several other aspects of library service not directly related to computers. Following an introduction and a list of officers, the papers are: (1) "Criminal Justice and Related Databases" (Kate E. Adams); (2) "Software and Hard Thought:…

  19. Changing Dimensions: Managing Library and Information Services for the 1990s: A Global Perspective. Proceedings of the Asian/Pacific American Librarians Association [Conference] (Atlanta, Georgia, July 1, 1991).

    ERIC Educational Resources Information Center

    Sharma, Ravindra Nath, Ed.

    The theme of the 1991 Asian/Pacific American Librarians Association (APALA) was "Changing Dimensions: Managing Library Information Services for the 1990s and Beyond." Members and speakers were invited to discuss this topic from all dimensions of library and information related fields. Presenters had the options either to write on actual…

  20. Total Quality Management in Academic Libraries: Initial Implementation Efforts. Proceedings from the International Conference on TQM and Academic Libraries (1st, Washington, D.C., April 20-22, 1994).

    ERIC Educational Resources Information Center

    Rounds, Laura, Ed.; Matthews, Michael, Ed.

    This document contains conference papers, other speeches, and supplementary material from the first International Conference on Total Quality Management (TQM) and Academic Libraries, held in 1994. The conference was comprised of four sessions, and the introductory remarks of each are included, along with transcriptions of each session's…

  1. Year of the Oceans: Science of Information Handling. [Proceedings of the] Annual Conference of the International Association of Marine Science Libraries and Information Centers (10th, Woods Hole, Massachusetts, October 2-5, 1984).

    ERIC Educational Resources Information Center

    Grundy, R. L., Ed.; Ford, R. T., Ed.

    International Association of Marine Science Libraries and Information Centers (IAMSLIC) conferences provide a format for libraries and information specialists to discuss common interests and concerns so that services and information can be made available to scientists, administrators, engineers, educators and students in the discipline of marine…

  2. The Library Technician at Work: Theory and Practice; Proceedings of a Workshop (Thunder Bay, Ontario, May 8-9, 1970).

    ERIC Educational Resources Information Center

    Campbell, Allan, Ed.; Dawson, Irene, Ed.

    On May 8 and 9, 1970, 170 people from six provinces and four states gathered in Thunder Bay, Ontario, at Lakehead University, for a two-day workshop on the subject of library technicians. The objectives of this workshop were: (1) to consider the role of library assistants or technicians and the type of post-secondary school training which they…

  3. The Future of Government Information: Money, Management, and Technology. Summaries of Proceedings of the FLICC Forum on Federal Information Policies (9th, Washington, D.C., March 17, 1992).

    ERIC Educational Resources Information Center

    Mulford, Carolyn

    This report contains summaries of papers presented at the annual forum of the Federal Library and Information Center Committee (FLICC) of the Library of Congress. Introductory and special remarks were delivered by FLICC Executive Director Mary Berghaus Levering, Associate Librarian for Constituent Services of the Library of Congress Donald C.…

  4. The Coming of Age of LTAs: Proceedings of the Meeting; Council on Library Technology (Fourth Annual, Palm Beach, Florida, June 4-6, 1970).

    ERIC Educational Resources Information Center

    Rudnik, Mary Chrysantha, Ed.

    The actual performance and use of library technical assistants (LTSs) and the question of certification were the topics considered by the sixty participants at this meeting. Evidence of the existence and use of LTAs was given by Mrs. Elnora Portteus in her paper entitled: "The Role of Library Technical Assistants - Actual and Potential," in which…

  5. Virtual Libraries: Virtual Communities. Abstracts, Fulltext Documents and PowerPoint Presentations of Papers and Demos Given at the International Association of Technological University Libraries (IATUL) Conference (Brisbane, Queensland, Australia, July 3-7, 2000).

    ERIC Educational Resources Information Center

    International Association of Technological Univ. Libraries, Gothenburg (Sweden).

    This proceedings of the International Association of Technological University Libraries (IATUL) contains the opening address by IATUL president Nancy Fjallbrant and the full text of the following papers: "Building Info-Skills by Degrees: Embedding Information Literacy in University Study" (Wendy Abbott and Deborah Peach); "UQ…

  6. Trends in Library and Information Science: 1989. ERIC Digest.

    ERIC Educational Resources Information Center

    Eisenberg, Michael B.

    Based on a content analysis of professional journals, conference proceedings, ERIC documents, annuals, and dissertations in library and information science, the following current trends in the field are discussed: (1) there are important emerging roles and responsibilities for information professionals; (2) the status and image of librarians…

  7. 76 FR 591 - Determination of Rates and Terms for Preexisting Subscription and Satellite Digital Audio Radio...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-05

    ... LIBRARY OF CONGRESS Copyright Royalty Board [Docket No. 2011-1 CRB PSS/Satellite II] Determination of Rates and Terms for Preexisting Subscription and Satellite Digital Audio Radio Services AGENCY: Copyright Royalty Board, Library of Congress. ACTION: Notice announcing commencement of proceeding with...

  8. Trends & Issues in Library & Information Science 1990.

    ERIC Educational Resources Information Center

    Eisenberg, Michael B.; And Others

    This synthesis paper provides a state-of-the-art analysis of the field of library and information science based on the results of a content analysis of its literature, including selected journals, conference proceedings, dissertations, and ERIC input. The 14 trends and issues identified by the analysis include developments in technology,…

  9. Proceedings of the Second Texas Conference on Library Automation (Houston, March 27, 1969).

    ERIC Educational Resources Information Center

    Corbin, John B., Ed.

    Four papers are included in these proceedings. The first three discuss specific on-going programs, including details of operation: (1) "Automation of Serials," by Shula Schwartz and Patricia A. Bottalico, reports a serials records automation at Texas Instruments Inc., Dallas, Texas; (2) "From Texana to Real-Time Automation," by…

  10. Online Information 96. Proceedings of the International Online Information Meeting (20th, London, England, UK, December 3-5, 1996).

    ERIC Educational Resources Information Center

    Raitt, David I., Ed.; Jeapes, Ben, Ed.

    This proceedings volume contains 68 papers. Subjects addressed include: access to information; the future of information managers/librarians; intelligent agents; changing roles of library users; disintermediation; Internet review sites; World Wide Web (WWW) search engines; Java; online searching; future of online education; integrated information…

  11. Alternative Energy: A Bay Area Reference Center Workshop. Proceedings.

    ERIC Educational Resources Information Center

    Roberts, Kay, Ed.; And Others

    Presented are proceedings and related documents of a workshop on alternative energy resources which was held in April, 1980. This information is intended to bring reference librarians up to date on alternative energy technologies and available reference materials to which library patrons may be directed. Among the speeches included are those…

  12. Charleston Conference Proceedings (21st, Charleston, South Carolina, November 1-3, 2001).

    ERIC Educational Resources Information Center

    Strauch, Katina, Ed.

    This proceedings of the 2001 Charleston Conference on library science contains the keynote address and the text of 27 presentations discussing the latest developments in the digital environment, serials, collection development, books and publishing, consortia, and personnel development as follows: "The Trends They Are A'Changing" (Tom Sanville);…

  13. Technology: Today and Tomorrow. Proceedings of the Spring Meeting of the Nebraska Library Association--College and University Section and Special and Institutional Section (Fremont, Nebraska, May 22, 1992).

    ERIC Educational Resources Information Center

    Pearson, Debra, Ed.

    The papers presented at this conference challenged participants to become an integral part of the planning necessary to keep libraries on the cutting edge of technological advances. Academic libraries are admonished to reposition themselves to deliver both new and traditional services, or face the prospect of being preempted by other agencies. The…

  14. Libraries, Archives and Museums: What's in Them for Us? PIALA '98. Selected Papers from the Pacific Islands Association of Libraries and Archives Conference (8th, Tofol, Kosrae, Federated States of Micronesia, November 17-20, 1998).

    ERIC Educational Resources Information Center

    Cohen, Arlene, Ed.

    This proceedings contains papers from the 1998 annual conference of the Pacific Islands Association of Libraries and Archives (PIALA). After welcoming remarks from Henry Robert and Isabel Rungrad, the following papers are included: "Sharing Our Successes, Discussing Our Future: A Survey of Pacific Collections Activities--Report from the…

  15. Toward a Common Vision in Library Networking. Proceedings of the Library of Congress Network Advisory Committee Meeting (Washington, D.C., December 9-11, 1985). Network Planning Paper No. 13.

    ERIC Educational Resources Information Center

    Harriman, Sigrid G., Ed.

    The December 1985 program session of the Library of Congress Network Advisory Committee (NAC) focused on determining the effectiveness of networking, identifying a common vision or goal, and developing a strategy to accomplish that goal. The program session included remarks on the role of the regional networks in national networking by Louella V.…

  16. The School Library: Centre for Life-Long Learning. Proceedings of the Annual Conference of the International Association of School Librarianship (18th, Subang Jaya, Selangor, Malaysia, July 22-26, 1989).

    ERIC Educational Resources Information Center

    Siong, Wong Kim, Ed.; And Others

    This conference report contains 5 addresses and 29 reports on the general theme of the school library as a center for lifelong learning. Submitted by librarians throughout the world, the reports reflect theoretical as well as practical perspectives, and include the following topics: (1) establishing, developing, and evaluating library resource…

  17. Artificial Intelligence and Expert Systems: Will They Change the Library? Papers Presented at the Annual Clinic on Library Applications of Data Processing (27th, Urbana, Illinois, March 25-27, 1990). Illinois, March 25-27, 1990).

    ERIC Educational Resources Information Center

    Lancaster, F. W., Ed.; Smith, Linda C., Ed.

    Some of the 12 conference papers presented in this proceedings focus on the present and potential capabilities of artificial intelligence and expert systems as they relate to a wide range of library applications, including descriptive cataloging, technical services, collection development, subject indexing, reference services, database searching,…

  18. 1978 Army Library Institute, 22-26 May 1978. Fort Bliss, Texas. A report of the Proceedings

    DTIC Science & Technology

    1978-10-01

    functions of management, librarianship and information science. - To encourage greater self-appraisal and self-development efforts. - To explore some...series of manuals describing the process in detail. This study impacts heavily on Army libraries, which use ALA standards of service as well as... STUDY OF ARMY LIBRARIES: Today Where Do We Stand .MAJ Paul Tracy Girard The Office of the Adjutant General Plans and Operations Directorate

  19. Key Issues in the Networking Field Today. Proceedings of the Library of Congress Network Advisory Committee Meeting (Washington, DC, May 6-8, 1985). Network Planning Paper No. 12.

    ERIC Educational Resources Information Center

    Library of Congress, Washington, DC. Network Development Office.

    The May 1985 program session of the Library of Congress Network Advisory Committee focused on the identification of key issues in the networking field. Presentations included discussions of major network developments in the last two decades, the changing network players, the impact of technology on networks, and library networks and the law. The…

  20. Where Library History Meets the Future: Proceedings of the 43rd Annual Military Librarians Workshop

    DTIC Science & Technology

    2001-04-04

    way things turn out.” Prusak’s final advice at SLA in June—“Don’t stick with library science stuff, but understand how your organization will be...gives the written subject-matter test in library science to persons seeking to qualify for GS 1410 Librarian series positions. Persons who want to...the Army’s practice to recruit librarians with Masters in Library Science “ it is neither the policy nor the practice of the US ARMY to hire non

  1. Writing DNA with GenoCAD.

    PubMed

    Czar, Michael J; Cai, Yizhi; Peccoud, Jean

    2009-07-01

    Chemical synthesis of custom DNA made to order calls for software streamlining the design of synthetic DNA sequences. GenoCAD (www.genocad.org) is a free web-based application to design protein expression vectors, artificial gene networks and other genetic constructs composed of multiple functional blocks called genetic parts. By capturing design strategies in grammatical models of DNA sequences, GenoCAD guides the user through the design process. By successively clicking on icons representing structural features or actual genetic parts, complex constructs composed of dozens of functional blocks can be designed in a matter of minutes. GenoCAD automatically derives the construct sequence from its comprehensive libraries of genetic parts. Upon completion of the design process, users can download the sequence for synthesis or further analysis. Users who elect to create a personal account on the system can customize their workspace by creating their own parts libraries, adding new parts to the libraries, or reusing designs to quickly generate sets of related constructs.

  2. 36 CFR 703.17 - Procedures when testimony and/or documents are demanded.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    .../or documents are demanded. 703.17 Section 703.17 Parks, Forests, and Public Property LIBRARY OF CONGRESS DISCLOSURE OR PRODUCTION OF RECORDS OR INFORMATION Testimony by Employees and Production of Documents in Certain Legal Proceedings Where the Library Is Not a Party § 703.17 Procedures when testimony...

  3. Rethinking Customer Service Training: A Curricular Solution to a Familiar Problem

    ERIC Educational Resources Information Center

    Epps, Sharon K.; Kidd, Judith; Negro, Toni; Sayles, Sheridan L.

    2016-01-01

    High-quality customer service is an important aim of the library experience. Its importance is evidenced by attention given to the topic in scholarly literature and academic conference proceedings. This article describes the challenging process of creating and delivering a blended customer service training curriculum to all library staff working…

  4. A novel route for preparing 5′ cap mimics and capped RNAs: phosphate-modified cap analogues obtained via click chemistry† †Electronic supplementary information (ESI) available: Tables S1–S6 and Fig. S1–S10, experimental procedures, HPLC profiles, NMR and HRMS spectra. See DOI: 10.1039/c6sc02437h Click here for additional data file. Click here for additional data file.

    PubMed Central

    Walczak, Sylwia; Nowicka, Anna; Kubacka, Dorota; Fac, Kaja; Wanat, Przemyslaw; Mroczek, Seweryn; Kowalska, Joanna

    2017-01-01

    The significant biological role of the mRNA 5′ cap in translation initiation makes it an interesting subject for chemical modifications aimed at producing useful tools for the selective modulation of intercellular processes and development of novel therapeutic interventions. However, traditional approaches to the chemical synthesis of cap analogues are time-consuming and labour-intensive, which impedes the development of novel compounds and their applications. Here, we explore a different approach for synthesizing 5′ cap mimics, making use of click chemistry (CuAAC) to combine two mononucleotide units and yield a novel class of dinucleotide cap analogues containing a triazole ring within the oligophosphate chain. As a result, we synthesized a library of 36 mRNA cap analogues differing in the location of the triazole ring, the polyphosphate chain length, and the type of linkers joining the phosphate and the triazole moieties. After biochemical evaluation, we identified two analogues that, when incorporated into mRNA, produced transcripts translated with efficiency similar to compounds unmodified in the oligophosphate bridge obtained by traditional synthesis. Moreover, we demonstrated that the triazole-modified cap structures can be generated at the RNA 5′ end using two alternative capping strategies: either the typical co-transcriptional approach, or a new post-transcriptional approach based on CuAAC. Our findings open new possibilities for developing chemically modified mRNAs for research and therapeutic applications, including RNA-based vaccinations. PMID:28451173

  5. Click C@refully Before You Quote: Citing Internet-Based Sources

    PubMed Central

    1999-01-01

    At the end of the 20th century, access to information provided by the World Wide Web (WWW) is changing as never before. The fast availability of current medical literature and the availability of tools for easy access to information, as well as for the easy production of information, have confronted research physicians, scholars, and students with new kinds of problems, many of which concern us personally. Quality control, difficulty establishing basic citation components, lack of standard guidelines for citing, as well as the short lifetime of Internet addresses concern us deeply. Some of these problems could be solved by the concept of an “Online-Library of Medicine” presented in the following paper. Since, however, at the present time there are no good answers to the problems regarding citing Internet-based sources, a Web surfer must keep in his or her mind the motto “caveat lector” (let the reader beware) - or, rather, in the spirit of our time: click c@refully before you cite. PMID:10527339

  6. A convergent approach to biocompatible polyglycerol "click" dendrons for the synthesis of modular core-shell architectures and their transport behavior.

    PubMed

    Wyszogrodzka, Monika; Haag, Rainer

    2008-01-01

    Dendrimers are an important class of polymeric materials for a broad range of applications in which monodispersity and multivalency are of interest. Here we report on a highly efficient synthetic route towards bifunctional polyglycerol dendrons on a multigram scale. Commercially available triglycerol (1), which is highly biocompatible, was used as starting material. By applying Williamson ether synthesis followed by an ozonolysis/reduction procedure, glycerol-based dendrons up to the fourth generation were prepared. The obtained products have a reactive core, which was further functionalized to the corresponding monoazido derivatives. By applying copper(I)-catalyzed 1,3-dipolar cycloaddition, so-called "click" coupling, a library of core-shell architectures was prepared. After removal of the 1,2-diol protecting groups, water-soluble core-shell architectures 24-27 of different generations were obtained in high yields. In the structure-transport relationship with Nile red we observe a clear dependence on core size and generation of the polyglycerol dendrons.

  7. Proceedings of Conference on Hydrocarbon Contaminated Soils (3rd) Held in Amherst, Massachusetts on September 1989 (Petroleum Contaminated Soils. Volume 3)

    DTIC Science & Technology

    1990-10-01

    Center Amherst, MA 01003-0081 REPORT DATE: October 1 , 1990 TYPE OF REPORT: Final Proceedings - PREPARED FOR: U.S. ARMY MEDICAL RESEARCH AND...Environmental Health Sciences Program University of Massachusetts, Amherst 1 * LEWIS PUBLISHERS I Library of Congress Cataloging-in-Publication Data...and 30, 1987"-V. 1 , pref. "The proceedings of the Third National Conference on Petroleum Contami- nated Soils held at the University of Massachusetts

  8. Mid-South Instructional Technology Conference Proceedings (1st, Murfreesboro, Tennessee, March 31-April 2, 1996).

    ERIC Educational Resources Information Center

    Southeast Missouri State Univ., Cape Girardeau.

    Papers in this proceedings discuss and demonstrate the impact of emerging information technologies on the education process. Along with two general session papers and two poster session papers, the bulk of the document is comprised of papers offered in the five tracks of Technology and Pedagogy, Distance Learning, Library Support, Support for…

  9. Spotlight on the Future. NECC '99: National Educational Computing Conference Proceedings (20th, Atlantic City, NJ, June 22-24, 1999).

    ERIC Educational Resources Information Center

    International Society for Technology in Education, Eugene, OR.

    This proceedings contains summaries of sessions on topics related to the use of computing across a wide range of disciplines and levels of education, including curriculum and instructional strategies, current and emerging technologies, social and ethical issues, library/media, technology implementation, exhibitors, teacher education and training,…

  10. PIALA '95. Preservation of Culture through Archives and Libraries. Papers from the Annual Pacific Islands Association of Libraries and Archives Conference (5th, Colonia, Yap, Federated States of Micronesia, November 6-10, 1995).

    ERIC Educational Resources Information Center

    Cohen, Arlene, Ed.

    The annual conference of the Pacific Islands Association of Libraries and Archives addressed various topics of interest to librarians, archivists, and educators in the Pacific Islands. The proceedings include welcoming remarks by 2 Yap state government officials and PIALA President Herbert Del Rosario; a keynote address by Dr. Marcia J.…

  11. Libraries and Electronic Publishing: Promises and Challenges for the 90's. Festschrift in Honor of Richard M. Dougherty. Proceedings of the International Essen Symposium (14th, Essen, Germany, October 14-17, 1991). Publications of Essen University Library, 14.

    ERIC Educational Resources Information Center

    Helal, Ahmed H., Ed.; Weiss, Joachim W., Ed.

    The goal of the Essen symposium was to bring together internationally recognized librarians and library automation specialists to discuss new developments in electronic publishing. All 16 papers included in this collection were presented at the conference: (1) "Barriers to the Introduction of New Technology" (J. Andrew Braid); (2)…

  12. Extreme red shifted SERS nanotags† †Electronic supplementary information (ESI) available: General experimental details for the synthesis and characterization of dyes 1–14, intermediates 15–17, and HGNs; general description of the chemometrics used for principal component analysis; figures of SERS spectra of dye/HGN nanotags with 1280 nm excitation; extinction spectrum for HGNs; SERS spectra of Au and Ag nanoparticles and dye 13 aggregated with KCl; SERS spectra of dyes 13 and 14 on HGN not aggregated with KCl; details of mean plane angle calculations, tables of crystallographic data, atomic coordinates and equivalent isotropic displacement parameters, anisotropic placement parameters, bond lengths, bond angles, and hydrogen atom coordinates and isotropic displacement parameters for dye 14. CCDC 1040064. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c4sc03917c Click here for additional data file. Click here for additional data file.

    PubMed Central

    Bedics, Matthew A.; Kearns, Hayleigh; Cox, Jordan M.; Mabbott, Sam; Ali, Fatima; Shand, Neil C.; Faulds, Karen; Benedict, Jason B.

    2015-01-01

    Surfaced enhanced Raman scattering (SERS) nanotags operating with 1280 nm excitation were constructed from reporter molecules selected from a library of 14 chalcogenopyrylium dyes containing phenyl, 2-thienyl, and 2-selenophenyl substituents and a surface of hollow gold nanoshells (HGNs). These 1280 SERS nanotags are unique as they have multiple chalcogen atoms available which allow them to adsorb strongly onto the gold surface of the HGN thus producing exceptional SERS signals at this long excitation wavelength. Picomolar limits of detection (LOD) were observed and individual reporters of the library were identified by principal component analysis and classified according to their unique structure and SERS spectra. PMID:29308144

  13. Rapid Analysis of Protein Farnesyltransferase Substrate Specificity Using Peptide Libraries and Isoprenoid Diphosphate Analogues

    PubMed Central

    2015-01-01

    Protein farnesytransferase (PFTase) catalyzes the farnesylation of proteins with a carboxy-terminal tetrapeptide sequence denoted as a Ca1a2X box. To explore the specificity of this enzyme, an important therapeutic target, solid-phase peptide synthesis in concert with a peptide inversion strategy was used to prepare two libraries, each containing 380 peptides. The libraries were screened using an alkyne-containing isoprenoid analogue followed by click chemistry with biotin azide and subsequent visualization with streptavidin-AP. Screening of the CVa2X and CCa2X libraries with Rattus norvegicus PFTase revealed reaction by many known recognition sequences as well as numerous unknown ones. Some of the latter occur in the genomes of bacteria and viruses and may be important for pathogenesis, suggesting new targets for therapeutic intervention. Screening of the CVa2X library with alkyne-functionalized isoprenoid substrates showed that those prepared from C10 or C15 precursors gave similar results, whereas the analogue synthesized from a C5 unit gave a different pattern of reactivity. Lastly, the substrate specificities of PFTases from three organisms (R. norvegicus, Saccharomyces cerevisiae, and Candida albicans) were compared using CVa2X libraries. R. norvegicus PFTase was found to share more peptide substrates with S. cerevisiae PFTase than with C. albicans PFTase. In general, this method is a highly efficient strategy for rapidly probing the specificity of this important enzyme. PMID:24841702

  14. Negotiating for Computer Services. Proceedings of the 1977 Clinic on Library Applications of Data Processing.

    ERIC Educational Resources Information Center

    Divilbiss, J. L., Ed.

    To help the librarian in negotiating with vendors of automated library services, nine authors have presented methods of dealing with a specific service or situation. Paper topics include computer services, network contracts, innovative service, data processing, automated circulation, a turn-key system, data base sharing, online data base services,…

  15. 36 CFR 703.16 - Policy on presentation of testimony and production of documents.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Documents in Certain Legal Proceedings Where the Library Is Not a Party § 703.16 Policy on presentation of... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false Policy on presentation of testimony and production of documents. 703.16 Section 703.16 Parks, Forests, and Public Property LIBRARY OF...

  16. MECHANIZATION STUDY OF THE TECHNICAL LIBRARY U.S. NAVAL AVIONICS FACILITY, INDIANAPOLIS, INDIANA.

    ERIC Educational Resources Information Center

    KERSHAW, G.A.; AND OTHERS

    THE NAVAL AVIONICS FACILITY, INDIANAPOLIS (NAFI) TECHNICAL LIBRARY IS PLANNING A MECHANIZED SYSTEM TO PRODUCE A PERMUTED INDEX OF PERTINENT PERIODICAL REFERENCES AND PROCEEDINGS, WITH BOOKS AND DOCUMENTS TO BE ADDED LATER. INPUT TO THE SYSTEM IS PUNCHED PAPER TAPE PREPARED FROM THE SOURCE MATERIAL, AND THE PRIMARY PROGRAM IS A "CANNED"…

  17. Proceedings of the Conference on Application of Scanning Methodologies in Libraries (Beltsville, Maryland, November 17-18, 1988).

    ERIC Educational Resources Information Center

    Blamberg, Donald L., Ed.; And Others

    Planned and organized by the National Agricultural Library (NAL), the conference was designed to bring together people involved in scanning projects and to evaluate the feasibility of using hand-held scanning devices for transcribing bibliographic information during the cataloging and indexing processes. Ten previously unpublished papers and a…

  18. Trinational Library Forum Proceedings = Memorias [del] Foro Trinacional de Bibliotecas (5th, Mexico City, Mexico, February 23-25, 1995).

    ERIC Educational Resources Information Center

    Instituto Tecnologico de Monterrey (Mexico).

    At the fifth Trinational Library Forum in 1995, 165 librarians from the United States, Canada, and Mexico gathered to discuss topics of international librarianship and exchanges, copyright regulations, and professional accreditation in information science. Presentations, with the full text in both English and Spanish, include: (1)…

  19. PhysiomeSpace: digital library service for biomedical data

    PubMed Central

    Testi, Debora; Quadrani, Paolo; Viceconti, Marco

    2010-01-01

    Every research laboratory has a wealth of biomedical data locked up, which, if shared with other experts, could dramatically improve biomedical and healthcare research. With the PhysiomeSpace service, it is now possible with a few clicks to share with selected users biomedical data in an easy, controlled and safe way. The digital library service is managed using a client–server approach. The client application is used to import, fuse and enrich the data information according to the PhysiomeSpace resource ontology and upload/download the data to the library. The server services are hosted on the Biomed Town community portal, where through a web interface, the user can complete the metadata curation and share and/or publish the data resources. A search service capitalizes on the domain ontology and on the enrichment of metadata for each resource, providing a powerful discovery environment. Once the users have found the data resources they are interested in, they can add them to their basket, following a metaphor popular in e-commerce web sites. When all the necessary resources have been selected, the user can download the basket contents into the client application. The digital library service is now in beta and open to the biomedical research community. PMID:20478910

  20. Expedient construction of small molecule macroarrays via sequential palladium- and copper-mediated reactions and their ex situ biological testing.

    PubMed

    Frei, Reto; Breitbach, Anthony S; Blackwell, Helen E

    2012-05-01

    We report the highly efficient syntheses of a series of focused libraries in the small molecule macroarray format using Suzuki-Miyaura and copper-catalyzed azide-alkyne cycloaddition (or "click") reactions. The libraries were based on stilbene and triazole scaffolds, which are known to have a broad range of biological activities, including quorum-sensing (QS) modulation in bacteria. The library products were generated in parallel on the macroarray in extremely short reaction times (~10-20 min) and isolated in excellent purities. Biological testing of one macroarray library post-cleavage (ex situ) revealed several potent agonists of the QS receptor, LuxR, in Vibrio fischeri. These synthetic agonists, in contrast to others that we have reported, were only active in the presence of the native QS signal in V. fischeri, which is suggestive of a different mode of activity. Notably, the results presented herein showcase the ready compatibility of the macroarray platform with chemical reactions that are commonly utilized in small molecule probe and drug discovery today. As such, this work serves to expand the utility of the small molecule macroarray as a rapid and operationally straightforward approach toward the synthesis and screening of bioactive agents.

  1. PhysiomeSpace: digital library service for biomedical data.

    PubMed

    Testi, Debora; Quadrani, Paolo; Viceconti, Marco

    2010-06-28

    Every research laboratory has a wealth of biomedical data locked up, which, if shared with other experts, could dramatically improve biomedical and healthcare research. With the PhysiomeSpace service, it is now possible with a few clicks to share with selected users biomedical data in an easy, controlled and safe way. The digital library service is managed using a client-server approach. The client application is used to import, fuse and enrich the data information according to the PhysiomeSpace resource ontology and upload/download the data to the library. The server services are hosted on the Biomed Town community portal, where through a web interface, the user can complete the metadata curation and share and/or publish the data resources. A search service capitalizes on the domain ontology and on the enrichment of metadata for each resource, providing a powerful discovery environment. Once the users have found the data resources they are interested in, they can add them to their basket, following a metaphor popular in e-commerce web sites. When all the necessary resources have been selected, the user can download the basket contents into the client application. The digital library service is now in beta and open to the biomedical research community.

  2. Telecommunications and tomorrow

    NASA Astrophysics Data System (ADS)

    Hromocky, A.

    1981-08-01

    The various subject heading used by the Library of Congress, under which most books on telecommunications can be located in card, book, and online catalogs are listed. Recommended literature from the library's collections is cited in this noncomprehensive bibliography intended for those interested in studying the technological, social, and policy aspects of telecommunications. The library's classification number is given for the books, journal articles, government publications, conference proceedings, and technical reports, recommended all of which are listed by author entry. Abstracting and indexing services that cover relevant literature are included.

  3. Taking control of your digital library: how modern citation managers do more than just referencing.

    PubMed

    Mahajan, Amit K; Hogarth, D Kyle

    2013-12-01

    Physicians are constantly navigating the overwhelming body of medical literature available on the Internet. Although early citation managers were capable of limited searching of index databases and tedious bibliography production, modern versions of citation managers such as EndNote, Zotero, and Mendeley are powerful web-based tools for searching, organizing, and sharing medical literature. Effortless point-and-click functions provide physicians with the ability to develop robust digital libraries filled with literature relevant to their fields of interest. In addition to easily creating manuscript bibliographies, various citation managers allow physicians to readily access medical literature, share references for teaching purposes, collaborate with colleagues, and even participate in social networking. If physicians are willing to invest the time to familiarize themselves with modern citation managers, they will reap great benefits in the future.

  4. Library Services in Distance Education. Proceedings of a National Seminar (Adelaide, Australia, August 22-23, 1985).

    ERIC Educational Resources Information Center

    Gray, John, Ed.

    This seminar addressed various aspects of the provision of library and other services to external students. Resolutions carried at the end of the seminar are noted, and the full text is provided for the opening address, which summarizes the activities of the Commonwealth Tertiary Education Commission Standing Committee on External Studies, and the…

  5. Education in Library and Information Science. Proceedings of the International Conference (Dubrovnik, Yugoslavia, May 21-26, 1984).

    ERIC Educational Resources Information Center

    Mihel, Ivan, Ed.; Tudor-Silovic, Neva, Ed.

    1984-01-01

    An international conference attended by 59 participants from 12 countries was organized to present Yugoslavia as a case study to the international audience, to bring to the Yugoslav audience a variety of international experiences in library and information science education and training, and to acquaint participants with some of the new…

  6. Selected Conference Proceedings from the 1985 Videodisc, Optical Disk, and CD-ROM Conference and Exposition (Philadelphia, PA, December 10-12, 1985).

    ERIC Educational Resources Information Center

    Cerva, John R.; And Others

    1986-01-01

    Eight papers cover: optical storage technology; cross-cultural videodisc design; optical disk technology use at the Library of Congress Research Service and National Library of Medicine; Internal Revenue Service image storage and retrieval system; solving business problems with CD-ROM; a laser disk operating system; and an optical disk for…

  7. Federal Information Resources: Identification, Availability and Use; Proceedings of a Conference, Washington, D.C., March 26-27, 1970.

    ERIC Educational Resources Information Center

    1970

    The Conference was held because of a recognition by the Committee on Scientific and Technical Information (COSATI) Task Group on Library Programs and the Federal Library Committee of a fundamental responsibility to interact in a meaningful way with the non-Federal sector--the state, local and private users of Federal information resources. This…

  8. ALIA 2000. Capitalising on Knowledge: The Information Profession in the 21st Century (Canberra, Australia, October 23-26, 2000).

    ERIC Educational Resources Information Center

    Australian Library and Information Association, Deakin.

    This proceeding of the Australian Library and Information Association (ALIA) 2000 conference contains 64 papers presented at the main conference and 12 papers presented at the fringe conference. Topics covered include: the 21st century information environment; user perspectives of the future of the Internet; the user interface; public libraries in…

  9. Transitioning from Marketing-Oriented Design to User-Oriented Design: A Case Study

    ERIC Educational Resources Information Center

    Laster, Shari; Stitz, Tammy; Bove, Frank J.; Wise, Casey

    2011-01-01

    The transition to a new architecture and design for an academic library Web site does not always proceed smoothly. In this case study, a library at a large research university hired an outside Web development contractor to create a new architecture and design for the university's Web site using dotCMS, an open-source content management system. The…

  10. The Rural Bookmobile: Quality as a Basic Ingredient. Conference Proceedings (2nd, Columbus, Ohio, June 18-20, 1986).

    ERIC Educational Resources Information Center

    Vavrek, Bernard, Ed.; Pratt, Mary Lou, Ed.

    Nine papers make up this proceedings on bookmobile services to rural areas. The primary theme of the conference was "programming," with emphasis on quality of services and how to market the bookmobile in communities. Although the primary focus is on rural library services, many of the ideas in these papers can be applied to metropolitan…

  11. 37 CFR 251.64 - Disposition of petition; initiation of arbitration proceeding.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... OFFICE, LIBRARY OF CONGRESS COPYRIGHT ARBITRATION ROYALTY PANEL RULES AND PROCEDURES COPYRIGHT... made for noncommercial educational broadcasting and the satellite carrier compulsory license in...

  12. Preservation of Digital Information. Proceedings of the Membership Meeting of the Association of Research Libraries (131st, Washington, DC, October 15-17, 1997).

    ERIC Educational Resources Information Center

    Barrett, Jaia, Ed.; Wetzel, Karen A., Ed.

    The 131st meeting of the Association of Research Libraries (ARL) focused on preservation of digital information. The ARL Preservation Committee convened three panels of experts to highlight major issues raised by the archiving of digital resources, and to encourage discussion about options for operating models and criteria for digital archives.…

  13. PIALA '97. Wasahn Kamarain: Place of Enlightenment. Papers from the Pacific Islands Association of Libraries and Archives Conference (7th, Palikir, Pohnpei, November 3-5, 1997).

    ERIC Educational Resources Information Center

    Cohen, Arlene, Ed.

    This PIALA 1997 Proceedings follows the tradition of publishing papers from each annual conference of the Pacific Islands Association of Libraries and Archives (PIALA). After welcoming remarks from Sue Moses, Kapily Capelle, and Isabel Rungrad, the following papers are included: "Places of Enlightenment, Places of Dreams" (Maradel Gale);…

  14. Electronic Information Delivery Systems. Proceedings of the Library of Congress Network Advisory Committee Meeting (Washington, D.C., April 18-20, 1984). Network Planning Paper Number 9.

    ERIC Educational Resources Information Center

    Library of Congress, Washington, DC.

    The Program Session of the April 1984 meeting of the Library of Congress Network Advisory Committee (NAC) was devoted to discussion of electronic information delivery systems. Recent developments in six areas were covered: (1) electronic manuscript generation and transmission; (2) online full-text searching and retrieval; (3) online database…

  15. Trinational Library Forum [Proceedings] = Memorias del Foro Trinacional de Bibliotecas = [Actes de] Forum Trinational Des Bibliotheques (4th, Monterrey, Mexico, February 24-26, 1994).

    ERIC Educational Resources Information Center

    Instituto Tecnologico de Monterrey (Mexico).

    At the fourth Trinational Library Forum in 1994, librarians from the United States, Canada, and Mexico gathered to discuss topics of international librarianship. Presentations, some in English and some in Spanish with a brief English language summary, include: (1) "Perspectivas de la Produccion y Exportaciones de la Industria Editorial…

  16. Transborder Library Forum Proceedings = Memorias del Foro Binacional de Bibliotecas (1st, Nogales, Arizona, February 1-2, 1991).

    ERIC Educational Resources Information Center

    Baldwin, Charlene M., Comp.

    At the first Transborder Library Forum in 1991, 132 librarians from the United States and Mexico gathered to get to know one another, discuss issues of common interest, and begin to build an international network. Conference materials are provided in both English and Spanish. Keynote addresses were delivered by Alberto Alvaro Rios and Jesus Lau.…

  17. Visualizing Subject Access for 21st Century Information Resources. Papers Presented at the Clinic on Library Applications of Data Processing (34th, Urbana, Illinois, March 2-4, 1997).

    ERIC Educational Resources Information Center

    Cochrane, Pauline Atherton, Ed.; Johnson, Eric H., Ed.

    This proceedings represents and documents in part the 16 presentations made at the 34th Annual Clinic on Library Applications of Data Processing. World Wide Web URLs that provide insight into each presentation are included. Presentations include: (1) "Hypostatizing Data Collections, Especially Bibliographic: Abstractions, Representations,…

  18. Consortial Leadership: Cooperation in a Competitive Environment. Proceedings of the Meeting of the Association of Research Libraries (130th, Albuquerque, NM, May 14-16, 1997).

    ERIC Educational Resources Information Center

    Barrett, Jaia, Ed.; Wetzel, Karen A., Ed.

    The program of the 130th meeting of the Association of Research Libraries (ARL) explored the leadership challenges posed by the juxtapositions of cooperation and competing priorities in a consortial environment. Following an opening and welcome (Gloria Werner, ARL Presiding President), and a Keynote Address, "Defining Successful…

  19. Confronting the Challenges of the Digital Era. Proceedings of the Membership Meeting of the Association of Research Libraries (133rd, Washington, DC, October 14-16, 1998).

    ERIC Educational Resources Information Center

    Bhalla, Nicole, Ed.; Barrett, Jaia, Ed.; Wetzel, Karen A., Ed.

    The 133rd meeting of the Association of Research Libraries (ARL) focused on strategies for confronting critical challenges associated with the digital era and for fostering understanding from university leaders and supporters regarding the resources needed to perform successfully in this print plus digital environment. Program Session I,…

  20. Libraries and the Search for Academic Excellence. Proceedings of the Arden House Symposium (New York, New York, March 15-17, 1987).

    ERIC Educational Resources Information Center

    1987

    In the introductory paper Patricia Senn Breivik provides background information on and an overview of a national symposium. This introduction is followed by the full text of nine papers presented at the symposium: (1) "The Academic Library and Education for Leadership" (Major R. Owens, U.S. House of Representatives); (2) "Academic…

  1. Proceedings of a Conference on Telecommunication Technologies, Networkings and Libraries

    NASA Astrophysics Data System (ADS)

    Knight, N. K.

    1981-12-01

    Current and developing technologies for digital transmission of image data likely to have an impact on the operations of libraries and information centers or provide support for information networking are reviewed. Technologies reviewed include slow scan television, teleconferencing, and videodisc technology and standards development for computer network interconnection through hardware and software, particularly packet switched networks computer network protocols for library and information service applications, the structure of a national bibliographic telecommunications network; and the major policy issues involved in the regulation or deregulation of the common communications carriers industry.

  2. Association of Small Computer Users in Education: Proceedings of the ASCUE Summer Conference (31st, North Myrtle Beach, South Carolina, June 7-11, 1998).

    ERIC Educational Resources Information Center

    Smith, Peter, Ed.

    Topics addressed by the papers including in this proceedings include: multimedia in the classroom; World Wide Web site development; the evolution of academic library services; a Web-based literature course; development of a real-time intelligent network environment; serving grades over the Internet; e-mail over a Web browser; using technology to…

  3. Federal Information Policies: The Congressional Initiative. A Summary of Proceedings of the Annual Forum on Federal Information Policies (6th, Washington, D.C., March 22, 1989).

    ERIC Educational Resources Information Center

    Price, Douglas

    This booklet summarizes the proceedings of a forum--whose audience consisted of over 200 library and information managers, congressional staff members, and persons from the information industry and academic community--on the condition of federal information policies as they relate to the Congressional initiative. Among issues discussed are: (1)…

  4. PIALA '94. Pacific Information Liberation: The Wave of the Future. Proceedings of the Annual Pacific Islands Association of Libraries and Archives Conference (4th, Tamuning, Guam, November 4-9, 1994).

    ERIC Educational Resources Information Center

    Cohen, Arlene, Ed.

    Over 100 participants from Micronesia, Australia, Japan, Hawaii, and other United States convened to hear presenters speaking on various topics of interest to librarians, archivists, and educators in the Pacific islands. The proceedings include a welcoming speech, remarks acknowledging conference exhibitors, and a keynote address by Dr. John…

  5. Engineering single-molecule, nanoscale, and microscale bio-functional materials via click chemistry

    NASA Astrophysics Data System (ADS)

    Daniele, Michael Angelo-Anthony

    To expand the design envelope and supplement the materials library available to biomaterials scientists, the copper(I)-catalyzed azide-alkyne cycloaddition (CuCAAC) was explored as a route to design, synthesize and characterize bio-functional small-molecules, nanoparticles, and microfibers. In each engineered system, the use of click chemistry provided facile, bio-orthogonal control for materials synthesis; moreover, the results provided a methodology and more complete, fundamental understanding of the use of click chemistry as a tool for the synergy of biotechnology, polymer and materials science. Fluorophores with well-defined photophysical characteristics (ranging from UV to NIR fluorescence) were used as building blocks for small-molecule, fluorescent biosensors. Fluorophores were paired to exhibit fluorescence resonant energy transfer (FRET) and used to probe the metabolic activity of carbazole 1,9a-dioxygenase (CARDO). The FRET pair exhibited a significant variation in PL response with exposure to the lysate of Pseudomonas resinovorans CA10, an organism which can degrade variants of both the donor and acceptor fluorophores. Nanoparticle systems were modified via CuCAAC chemistry to carry affinity tags for CARDO and were subsequently utilized for affinity based bioseparation of CARDO from crude cell lysate. The enzymes were baited with an azide-modified carbazolyl-moiety attached to a poly(propargyl acrylate) nanoparticle. Magnetic nanocluster systems were also modified via CuCAAC chemistry to carry fluorescent imaging tags. The iron-oxide nanoclusters were coated with poly(acrylic acid-co-propargyl acrylate) to provide a clickable surface. Ultimately, alternate Cu-free click chemistries were utilized to produce biohybrid microfibers. The biohybrid microfibers were synthesized under benign photopolymerization conditions inside a microchannel, allowing the encapsulation of viable bacteria. By adjusting pre-polymer solutions and laminar flow rates within the microchannel, the morphology, hydration, and thermal properties of the fibers were easily tuned. The methodology produced hydrogel fibers that sustained viable cells as demonstrated by the encapsulation and subsequent proliferation of Bacillus cereus and Escherichia coli communities.

  6. The Public's Information: Striking a Balance Between Access and Control: A Summary of Proceedings of the FLICC Forum on Federal Information Policies (Washington, DC, March 19, 1996).

    ERIC Educational Resources Information Center

    Federal Library and Information Center Committee, Washington, DC.

    This report is a summary of topics presented at the annual forum of the Federal Library and Information Center Committee (FLICC) of the Library of Congress. The first portion of the Forum examined information availability issues and reviewed government publishing and access arrangements in the United States and other democratic countries.…

  7. Riding the Electronic Wave--Document Delivery: Proceedings of the Library of Congress Network Advisory Committee Meeting (Washington, D.C., November 29-December 1, 1989). Network Planning Paper Number 20.

    ERIC Educational Resources Information Center

    Library of Congress, Washington, DC. Network Development and MARC Standards Office.

    Papers delivered at the 1989 program session of the Library of Congress Network Advisory Committee (NAC) focused on ways in which newer technologies and document delivery networks are changing current practices in document delivery and information services. Charles P. Bourne, chair of the program committee, presented an overview of document…

  8. Collecting, Preserving & Sharing Information in Micronesia. Proceedings of the Annual Pacific Islands Association of Libraries and Archives Conference (3rd, Saipan, Northern Mariana Islands, October 13-15, 1993).

    ERIC Educational Resources Information Center

    Pacific Islands Association of Libraries and Archives, Guam.

    Participants from Washington, Hawaii, Majuro, Palau, Guam and other points in the Northern Mariana Islands came together to share information relating to the functions of libraries and archives as information banks and as preservers of the cultural heritage of Micronesia. Papers presented were: (1) "Reading Motivation in the Pacific"…

  9. Proceedings of Military Librarians' Workshop. The User and the Library (11th, Wright-Patterson Air Force Base, October 31-November 2, 1967).

    ERIC Educational Resources Information Center

    Air Force Inst. of Tech., Wright-Patterson AFB, OH.

    The purpose of this workshop was to investigate the problems the user faces in using a military library and to develop some methods of overcoming these problems. To provide balanced representation of both users and librarians, outside speakers contributed ideas that were discussed in group meetings. Each group discussed the same major topics,…

  10. Health Care Worker Fatigue.

    PubMed

    Gardner, Lea Anne; Dubeck, Deborah

    2016-08-01

    The Pennsylvania Patient Safety Reporting System is a confidential, statewide Internet reporting system to which all Pennsylvania hospitals, outpatient-surgery facilities, birthing centers, and abortion facilities must file information on incidents and serious events.Safety Monitor is a column from Pennsylvania's Patient Safety Authority, the authority that informs nurses on issues that can affect patient safety and presents strategies they can easily integrate into practice. For more information on the authority, visit www.patientsafetyauthority.org. For the original article discussed in this column or for other articles on patient safety, click on "Patient Safety Advisories" and then "Advisory Library" in the left-hand navigation menu.

  11. Federal Information Policies: The Impact on Competitiveness. A Summary of Proceedings of a Federal Library and Information Center Committee (FLICC) Annual Forum on Federal Information Policies (5th, Washington, DC, March 7, 1988).

    ERIC Educational Resources Information Center

    Brooks, Douglas C.

    This booklet summarizes the proceedings of a forum on the state of federal information policies as they relate to aiding American competitiveness in industrial and information markets at home and abroad. Speakers whose remarks are summarized include Librarian of Congress James H. Billington; New York Congressman Sherwood Boehlert, the keynote…

  12. 36 CFR 705.6 - Compilation.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ....6 Compilation. (a) Library of Congress staff acting under the general authority of the Librarian of... segment. (c) No compilation by the Librarian shall be deemed for any purpose or proceeding to be an...

  13. PIALA '96. Jaketo Jaketak Kobban Alele Eo--Identifying, Using and Sharing Local Resources. Proceedings of the Annual Pacific Islands Association of Libraries and Archives Conference (6th, Majuro, Marshall Islands, November 5-8, 1996).

    ERIC Educational Resources Information Center

    Cohen, Arlene, Ed.

    This 1996 PIALA conference explores ways to identify and make available local resources on the Marshall Islands. The traditional Marshallese word, "Alele," which means "the basket which holds the tools, treasures and resources needed for everyday life," is also the name of Majuro's public library, museum and Marshall Islands…

  14. Contributed Papers Workshop. Proceedings of a Western New York/Ontario Chapter of the Association of College and Research Libraries (ACRL) Workshop (Buffalo, New York, September 26, 1988).

    ERIC Educational Resources Information Center

    Association of Coll. and Research Libraries. Western New York/Ontario Chapter.

    The eight papers in this collection were presented at an Association of College and Research Libraries workshop held in September 1988 in Buffalo, New York. The papers are as follows: (1) "Making Real Changes: Course Integrated Instruction and Its Impact, a Case Study" (Joan Ormondroyd); (2) "Dual Function Positions: A View from the Trenches" (Amy…

  15. The Emerging Information Infrastructure: Players, Issues, Technology, and Strategies. Proceedings of Part I of the Meeting of the Association of Research Libraries (123rd, Arlington, Virginia, October 20-22, 1993).

    ERIC Educational Resources Information Center

    Mogge, Dru, Ed.; And Others

    The topic of the 123rd meeting of the Association of Research Libraries (ARL) is the information infrastructure. The ARL is seeking to influence the policies that will form the backbone of the emerging information infrastructure. The first session concentrated on government roles and initiatives and included the following papers: "Opening…

  16. Proceedings of the Ship Control Systems Symposium (6th) Held in Ottawa, Canada on 26-30 October 1981. Supplement

    DTIC Science & Technology

    1981-10-30

    lIefCAL LIBRARY "... ........... . -FRMAi.- NOhL’ FR NO. .. 01 COL BY DR., OTTAWA, ONT - PUBLICATION INFORM1ATION - THESE PAPERS WERE PRINTED JIST AS...PROMINENTLY MAIRKED WITH THE COPYRIGHT SYMBOL AND WAS RELEASED FOR PUBLICATION IN THESE PROCEEDINGS. REQUESTS FOR INFORMA TION REGARDING THE...that was required to ensure this success. The Symposium organizing committee, advisory groups, publications branch, authors, session chairmen

  17. American Academy of Forensic Sciences

    MedlinePlus

    ... Academy News PDF Library Proceedings Journal of Forensic Sciences Information for Authors Searchable Index Contact Information Forensic Links ... Dale Stewart Award 2018 Annual Scientific Meeting Registration ... in Forensic Science … Now What? Young Forensic Scientists Forum (YFSF) Annual ...

  18. Investigating Biochemical and Developmental Dependencies of Lignification with a Click-Compatible Monolignol Analog in Arabidopsis thaliana Stems

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Pandey, Jyotsna L.; Kiemle, Sarah N.; Richard, Tom L.

    Lignin is a key structural component of plant cell walls that provides rigidity, strength, and resistance against microbial attacks. This hydrophobic polymer also serves a crucial role in water transport. Despite its abundance and essential functions, several aspects of lignin biosynthesis and deposition remain cryptic. Lignin precursors are known to be synthesized in the cytoplasm by complex biosynthetic pathways, after which they are transported to the apoplastic space, where they are polymerized via free radical coupling reactions into polymeric lignin. However, the lignin deposition process and the factors controlling it are unclear. In this study, the biochemical and developmental dependenciesmore » of lignification were investigated using a click-compatible monolignol analog, 3-O-propargylcaffeyl alcohol (3-OPC), which can incorporate into both in vitro polymerized lignin and Arabidopsis thaliana tissues. Fluorescence labeling of 3-OPC using click chemistry followed by confocal fluorescence microscopy enabled the detection and imaging of 3-OPC incorporation patterns. These patterns were consistent with endogenous lignification observed in different developmental stages of Arabidopsis stems. However, the concentration of supplied monolignols influenced where lignification occurred at the subcellular level, with low concentrations being deposited in cell corners and middle lamellae and high concentrations also being deposited in secondary walls. Experimental inhibition of multiple lignification factors confirmed that 3-OPC incorporation proceeds via a free radical coupling mechanism involving peroxidases/laccases and reactive oxygen species (ROS). Finally, the presence of peroxide-producing enzymes determined which cell walls lignified: adding exogenous peroxide and peroxidase caused cells that do not naturally lignify in Arabidopsis stems to lignify. In conclusion, 3-OPC accurately mimics natural lignification patterns in different developmental stages of Arabidopsis stems and allows for the dissection of key biochemical and enzymatic factors controlling lignification.« less

  19. Investigating Biochemical and Developmental Dependencies of Lignification with a Click-Compatible Monolignol Analog in Arabidopsis thaliana Stems

    PubMed Central

    Pandey, Jyotsna L.; Kiemle, Sarah N.; Richard, Tom L.; Zhu, Yimin; Cosgrove, Daniel J.; Anderson, Charles T.

    2016-01-01

    Lignin is a key structural component of plant cell walls that provides rigidity, strength, and resistance against microbial attacks. This hydrophobic polymer also serves a crucial role in water transport. Despite its abundance and essential functions, several aspects of lignin biosynthesis and deposition remain cryptic. Lignin precursors are known to be synthesized in the cytoplasm by complex biosynthetic pathways, after which they are transported to the apoplastic space, where they are polymerized via free radical coupling reactions into polymeric lignin. However, the lignin deposition process and the factors controlling it are unclear. In this study, the biochemical and developmental dependencies of lignification were investigated using a click-compatible monolignol analog, 3-O-propargylcaffeyl alcohol (3-OPC), which can incorporate into both in vitro polymerized lignin and Arabidopsis thaliana tissues. Fluorescence labeling of 3-OPC using click chemistry followed by confocal fluorescence microscopy enabled the detection and imaging of 3-OPC incorporation patterns. These patterns were consistent with endogenous lignification observed in different developmental stages of Arabidopsis stems. However, the concentration of supplied monolignols influenced where lignification occurred at the subcellular level, with low concentrations being deposited in cell corners and middle lamellae and high concentrations also being deposited in secondary walls. Experimental inhibition of multiple lignification factors confirmed that 3-OPC incorporation proceeds via a free radical coupling mechanism involving peroxidases/laccases and reactive oxygen species (ROS). Finally, the presence of peroxide-producing enzymes determined which cell walls lignified: adding exogenous peroxide and peroxidase caused cells that do not naturally lignify in Arabidopsis stems to lignify. In summary, 3-OPC accurately mimics natural lignification patterns in different developmental stages of Arabidopsis stems and allows for the dissection of key biochemical and enzymatic factors controlling lignification. PMID:27630649

  20. Investigating Biochemical and Developmental Dependencies of Lignification with a Click-Compatible Monolignol Analog in Arabidopsis thaliana Stems

    DOE PAGES

    Pandey, Jyotsna L.; Kiemle, Sarah N.; Richard, Tom L.; ...

    2016-08-31

    Lignin is a key structural component of plant cell walls that provides rigidity, strength, and resistance against microbial attacks. This hydrophobic polymer also serves a crucial role in water transport. Despite its abundance and essential functions, several aspects of lignin biosynthesis and deposition remain cryptic. Lignin precursors are known to be synthesized in the cytoplasm by complex biosynthetic pathways, after which they are transported to the apoplastic space, where they are polymerized via free radical coupling reactions into polymeric lignin. However, the lignin deposition process and the factors controlling it are unclear. In this study, the biochemical and developmental dependenciesmore » of lignification were investigated using a click-compatible monolignol analog, 3-O-propargylcaffeyl alcohol (3-OPC), which can incorporate into both in vitro polymerized lignin and Arabidopsis thaliana tissues. Fluorescence labeling of 3-OPC using click chemistry followed by confocal fluorescence microscopy enabled the detection and imaging of 3-OPC incorporation patterns. These patterns were consistent with endogenous lignification observed in different developmental stages of Arabidopsis stems. However, the concentration of supplied monolignols influenced where lignification occurred at the subcellular level, with low concentrations being deposited in cell corners and middle lamellae and high concentrations also being deposited in secondary walls. Experimental inhibition of multiple lignification factors confirmed that 3-OPC incorporation proceeds via a free radical coupling mechanism involving peroxidases/laccases and reactive oxygen species (ROS). Finally, the presence of peroxide-producing enzymes determined which cell walls lignified: adding exogenous peroxide and peroxidase caused cells that do not naturally lignify in Arabidopsis stems to lignify. In conclusion, 3-OPC accurately mimics natural lignification patterns in different developmental stages of Arabidopsis stems and allows for the dissection of key biochemical and enzymatic factors controlling lignification.« less

  1. Gauging User Interest in Non-Traditional Library Resources

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Sandberg, Tami; Abbott, Jennifer

    The National Renewable Energy Laboratory (NREL) is a government funded research laboratory based in Golden, Colorado. In addition to collecting traditional library resources such as journals, conference proceedings, and print and electronic books, the library also spends a significant portion of its collection development funds on resources not often found in many libraries: technical industry standards (e.g., ISO, IEC, ASTM, IEEE) and energy-related market reports. Assessing user needs for these resources is difficult for a number of reasons, particularly because standardized usage statistics are lacking or non-existent. Standards and market reports are generally costly and include fairly restrictive license agreements,more » which increase the importance of making informed collection development decisions. This presentation will discuss the NREL Library's current collection assessment and development practices as they relate to these unique resources.« less

  2. Proceedings of the Binational Conference on Libraries in California and Baja California (1st, Tijuana, Baja California, Mexico, January 13-14, 1984) = Memorias de la Primera Conferencia Binacional de Bibliotecas de las Californias.

    ERIC Educational Resources Information Center

    Ayala, Marta Stiefel, Ed.; And Others

    This document includes the text of presentations given at the First Binational Conference on Libraries in California and Baja California, as well as minutes from four roundtables held at the conference. Following a prologue and a brief background on the conference, the following presentations are included: (1) "State Support for Public…

  3. Army Library Institute V: Product/Marketing/Service - Volume I, Report of Proceedings

    DTIC Science & Technology

    1981-11-01

    Strategy for Survival" College and Research Libraries (July) pg. 328-332. Kotler , Philip (1975) Marketing for Nonprofit Organizations (Englewood...refer you to Philip Kotler’s, "Marketing for Non-Profit Organizations" (Prentice-Hall, 1975). The essential Idea of marketing concerns the process by...927-5017 Casey, Philip M. U.S. Army ARRCOM ATTN: DRSAR-LEP-L Rock Island, XL 61299 AV: 793-4208 Cass, Ed C. Chief Archivist, USMA West

  4. Disruption of the auditory response to a regular click train by a single, extra click.

    PubMed

    Lütkenhöner, Bernd; Patterson, Roy D

    2015-06-01

    It has been hypothesized that the steady-state response to a periodic sequence of clicks can be modeled as the superposition of responses to single clicks. Here, this hypothesis is challenged by presenting an extra click halfway between two consecutive clicks of a regular series, while measuring the auditory evoked field. After a solitary click at time zero, the click series sounded from 100 to 900 ms, with the extra click presented around 500 ms. The silent period between two stimulus sequences was 310-390 ms (uniformly distributed) so that one stimulation cycle lasted, on average, 1250 ms. Five different click rates between 20 and 60 Hz were examined. The disturbance caused by the extra click was revealed by subtracting the estimated steady-state response from the joint response to the click series and the extra click. The early peaks of the single-click response effectively coincide with same-polarity peaks of the 20-Hz steady-state response. Nevertheless, prediction of the latter from the former proved impossible. However, the 40-Hz steady-state response can be predicted reasonably well from the 20-Hz steady-state response. Somewhat surprisingly, the amplitude of the evoked response to the extra click grew when the click rate of the train was increased from 20 to 30 Hz; the opposite effect would have been expected from research on adaptation. The smaller amplitude at lower click rates might be explained by forward suppression. In this case, the apparent escape from suppression at higher rates might indicate that the clicks belonging to the periodic train are being integrated into an auditory stream, possibly in much the same manner as in classical stream segregation experiments.

  5. Weaver's historic accessible collection of synthetic dyes: a cheminformatics analysis† †The views expressed in this paper are those of the authors and do not necessarily reflect the views or policies of the US Environmental Protection Agency. Mention of trade names or commercial products does not constitute endorsement or recommendation for use. ‡ ‡Electronic supplementary information (ESI) available. See DOI: 10.1039/c7sc00567a Click here for additional data file.

    PubMed Central

    Kuenemann, Melaine A.; Szymczyk, Malgorzata; Chen, Yufei; Sultana, Nadia; Hinks, David; Freeman, Harold S.; Williams, Antony J.

    2017-01-01

    We present the Max Weaver Dye Library, a collection of ∼98 000 vials of custom-made and largely sparingly water-soluble dyes. Two years ago, the Eastman Chemical Company donated the library to North Carolina State University. This unique collection of chemicals, housed in the College of Textiles, also includes tens of thousands of fabric samples dyed using some of the library's compounds. Although the collection lies at the core of hundreds of patented inventions, the overwhelming majority of this chemical treasure trove has never been published or shared outside of a small group of scientists. Thus, the goal of this donation was to make this chemical collection, and associated data, available to interested parties in the research community. To date, we have digitized a subset of 2700 dyes which allowed us to start the constitutional and structural analysis of the collection using cheminformatics approaches. Herein, we open the discussion regarding the research opportunities offered by this unique library. PMID:28959395

  6. jsPhyloSVG: a javascript library for visualizing interactive and vector-based phylogenetic trees on the web.

    PubMed

    Smits, Samuel A; Ouverney, Cleber C

    2010-08-18

    Many software packages have been developed to address the need for generating phylogenetic trees intended for print. With an increased use of the web to disseminate scientific literature, there is a need for phylogenetic trees to be viewable across many types of devices and feature some of the interactive elements that are integral to the browsing experience. We propose a novel approach for publishing interactive phylogenetic trees. We present a javascript library, jsPhyloSVG, which facilitates constructing interactive phylogenetic trees from raw Newick or phyloXML formats directly within the browser in Scalable Vector Graphics (SVG) format. It is designed to work across all major browsers and renders an alternative format for those browsers that do not support SVG. The library provides tools for building rectangular and circular phylograms with integrated charting. Interactive features may be integrated and made to respond to events such as clicks on any element of the tree, including labels. jsPhyloSVG is an open-source solution for rendering dynamic phylogenetic trees. It is capable of generating complex and interactive phylogenetic trees across all major browsers without the need for plugins. It is novel in supporting the ability to interpret the tree inference formats directly, exposing the underlying markup to data-mining services. The library source code, extensive documentation and live examples are freely accessible at www.jsphylosvg.com.

  7. 6-Azido hyacinthacine A2 gives a straightforward access to the first multivalent pyrrolizidine architectures.

    PubMed

    D'Adamio, Giampiero; Parmeggiani, Camilla; Goti, Andrea; Moreno-Vargas, Antonio J; Moreno-Clavijo, Elena; Robina, Inmaculada; Cardona, Francesca

    2014-08-28

    The synthesis of the first multivalent pyrrolizidine iminosugars is reported. The key azido intermediates 4 and 31 were prepared after suitable synthetic elaboration of the cycloadduct obtained from 1,3-dipolar cycloaddition of D-arabinose derived nitrone to dimethylacrylamide. The key step of the strategy was the stereoselective installation of an azido moiety at C-6 of the pyrrolizidine skeleton. The click reaction with different monovalent and dendrimeric alkyne scaffolds allowed the preparation of a library of new mono- and multivalent pyrrolizidine compounds that were preliminarily assayed as glycosidase inhibitors towards a panel of commercially available glycosyl hydrolases.

  8. Caring for class III obese patients.

    PubMed

    Gardner, Lea Anne

    2013-11-01

    The Pennsylvania Patient Safety Reporting System is a confidential, statewide Internet reporting system to which all Pennsylvania hospitals, outpatient-surgery facilities, and birthing centers, as well as some abortion facilities, must file information on medical errors.Safety Monitor is a column from Pennsylvania's Patient Safety Authority, the authority that informs nurses on issues that can affect patient safety and presents strategies they can easily integrate into practice. For more information on the authority, visit www.patientsafetyauthority.org. For the original article discussed in this column or for other articles on patient safety, click on "Patient Safety Advisories" and then "Advisory Library" in the left-hand navigation menu.

  9. [Establishment and management of electronic appointment library for dental implant patients].

    PubMed

    Dong, Zheng-jie; Xu, Kan

    2013-10-01

    To design an excel form which can prompt dental implant patient appointment through color change, which can scientifically manage implant EMR library through appropriate interlinkage and number. An excel form based on operating system Windows XP was designed and software 2003 Microsoft excel was used, which was configured to change color with the passage of time by the use of command "conditional format". An excel form was designed. The color turned to red automatically on the day the patient underwent implant surgery. It turned to yellow when the patient recalled 2 weeks after the first operation, to green when the patient underwent secondary operation. It was designed to be gray when all the procedures of implant restoration was finished. In addition, we could know patients' main implant situation through directly opening his EMR when clicking on his name or number. Dentists can remind the implant patient appointment schedule through color change of an excel form, and can consult the implant patient EMR directly through interlinkage or number.

  10. 76 FR 53127 - Notice of Suspension and Commencement of Proposed Debarment Proceedings; Schools and Libraries...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-25

    ... . The text may also be purchased from the Commission's duplicating inspection and copying during regular... through August 2005 you offered and delivered $28,500 in bribes and kickbacks to various school officials...

  11. Automated classification of dolphin echolocation click types from the Gulf of Mexico.

    PubMed

    Frasier, Kaitlin E; Roch, Marie A; Soldevilla, Melissa S; Wiggins, Sean M; Garrison, Lance P; Hildebrand, John A

    2017-12-01

    Delphinids produce large numbers of short duration, broadband echolocation clicks which may be useful for species classification in passive acoustic monitoring efforts. A challenge in echolocation click classification is to overcome the many sources of variability to recognize underlying patterns across many detections. An automated unsupervised network-based classification method was developed to simulate the approach a human analyst uses when categorizing click types: Clusters of similar clicks were identified by incorporating multiple click characteristics (spectral shape and inter-click interval distributions) to distinguish within-type from between-type variation, and identify distinct, persistent click types. Once click types were established, an algorithm for classifying novel detections using existing clusters was tested. The automated classification method was applied to a dataset of 52 million clicks detected across five monitoring sites over two years in the Gulf of Mexico (GOM). Seven distinct click types were identified, one of which is known to be associated with an acoustically identifiable delphinid (Risso's dolphin) and six of which are not yet identified. All types occurred at multiple monitoring locations, but the relative occurrence of types varied, particularly between continental shelf and slope locations. Automatically-identified click types from autonomous seafloor recorders without verifiable species identification were compared with clicks detected on sea-surface towed hydrophone arrays in the presence of visually identified delphinid species. These comparisons suggest potential species identities for the animals producing some echolocation click types. The network-based classification method presented here is effective for rapid, unsupervised delphinid click classification across large datasets in which the click types may not be known a priori.

  12. Automated classification of dolphin echolocation click types from the Gulf of Mexico

    PubMed Central

    Roch, Marie A.; Soldevilla, Melissa S.; Wiggins, Sean M.; Garrison, Lance P.; Hildebrand, John A.

    2017-01-01

    Delphinids produce large numbers of short duration, broadband echolocation clicks which may be useful for species classification in passive acoustic monitoring efforts. A challenge in echolocation click classification is to overcome the many sources of variability to recognize underlying patterns across many detections. An automated unsupervised network-based classification method was developed to simulate the approach a human analyst uses when categorizing click types: Clusters of similar clicks were identified by incorporating multiple click characteristics (spectral shape and inter-click interval distributions) to distinguish within-type from between-type variation, and identify distinct, persistent click types. Once click types were established, an algorithm for classifying novel detections using existing clusters was tested. The automated classification method was applied to a dataset of 52 million clicks detected across five monitoring sites over two years in the Gulf of Mexico (GOM). Seven distinct click types were identified, one of which is known to be associated with an acoustically identifiable delphinid (Risso’s dolphin) and six of which are not yet identified. All types occurred at multiple monitoring locations, but the relative occurrence of types varied, particularly between continental shelf and slope locations. Automatically-identified click types from autonomous seafloor recorders without verifiable species identification were compared with clicks detected on sea-surface towed hydrophone arrays in the presence of visually identified delphinid species. These comparisons suggest potential species identities for the animals producing some echolocation click types. The network-based classification method presented here is effective for rapid, unsupervised delphinid click classification across large datasets in which the click types may not be known a priori. PMID:29216184

  13. Hydrosoluble Cu(i)-DAPTA complexes: synthesis, characterization, luminescence thermochromism and catalytic activity for microwave-assisted three-component azide-alkyne cycloaddition click reaction.

    PubMed

    Mahmoud, Abdallah G; Guedes da Silva, M Fátima C; Sokolnicki, Jerzy; Smoleński, Piotr; Pombeiro, Armando J L

    2018-05-16

    New hydrosoluble and air-stable Cu(i) halide compounds, viz. [CuX(DAPTA)3] (1) and (2), and [Cu(μ-X)(DAPTA)2]2 (3) and (4) (X = Br or I, in this order), have been prepared by reacting Cu(i) halide (i.e., bromide or iodide) with 3,7-diacetyl-1,3,7-triaza-5-phosphabicyclo[3.3.1]nonane (DAPTA) under mild conditions. They represent the first examples of Cu(i) halide complexes bearing the DAPTA ligand, which have been fully characterized by elemental analysis, IR, 1H, 13C{1H} and 31P{1H} NMR spectroscopies, ESI-MS+ and, for 4, also by single-crystal X-ray diffraction (SCXRD) analyses. Complexes 1-4 are efficient catalysts for the one-pot microwave assisted three-component (terminal alkyne, organic halide and NaN3) Huisgen cycloaddition reaction in aqueous media to afford the corresponding disubstituted triazoles. The catalysis proceeds with a broad alkyne substrate scope and according to "click rules". Photophysical studies of compound 4 showed an unusual reversible thermochromic behaviour exhibiting a blue emission at 298 K due to the halide-to-ligand charge transfer (3XLCT) and a red emission at 77 K because of the {Cu2I2} unit.

  14. Federal Information Policies: Their Implementation and Implications for Information Access. A Summary of the Proceedings of the Annual Federal Library and Information Center Committee Forum on Federal Information Policies (3rd, Washington, DC, February 12, 1986).

    ERIC Educational Resources Information Center

    Higgins, Adrian T.

    This Federal Library and Information Center Committee (FLICC) Forum on Federal Information Policies focused on the impact of OMB (Office of Management and Budget) Circular A-130, which revises administration policy on information dissemination and the use of automated systems by federal agencies. Introductory remarks by James P. Riley, Kent A.…

  15. Click rates and silences of sperm whales at Kaikoura, New Zealand

    NASA Astrophysics Data System (ADS)

    Douglas, Lesley A.; Dawson, Stephen M.; Jaquet, Nathalie

    2005-07-01

    Analysis of the usual click rates of sperm whales (Physeter macrocephalus) at Kaikoura, New Zealand, confirms the potential for assessing abundance via ``click counting.'' Usual click rates over three dive cycles each of three photographically identified whales showed that 5 min averages of usual click rate did not differ significantly within dives, among dives of the same whale or among whales. Over the nine dives (n=13 728 clicks) mean usual click rate was 1.272 clicks s-1 (95% CI=0.151). On average, individual sperm whales at Kaikoura spent 60% of their time usual clicking in winter and in summer. There was no evidence that whale identity or stage of the dive recorded affects significantly the percentage of time spent usual clicking. Differences in vocal behavior among sperm whale populations worldwide indicate that estimates of abundance that are based on click rates need to based on data from the population of interest, rather than from another population or some global average.

  16. 76 FR 68760 - Notice of Suspension and Commencement of Proposed Debarment Proceedings; Schools and Libraries...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-07

    ... obstructed a 2007 federal grand jury investigation by instructing a CMS employee to testify falsely before the grand jury about receiving gifts, and to destroy E-Rate program records and remove the hard drives...

  17. 37 CFR 251.40 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... of royalty fees. This subpart does not apply to other arbitration proceedings specified by 17 U.S.C... Patents, Trademarks, and Copyrights COPYRIGHT OFFICE, LIBRARY OF CONGRESS COPYRIGHT ARBITRATION ROYALTY PANEL RULES AND PROCEDURES COPYRIGHT ARBITRATION ROYALTY PANEL RULES OF PROCEDURE Procedures of...

  18. 37 CFR 255.7 - Future proceedings.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Section 255.7 Patents, Trademarks, and Copyrights COPYRIGHT OFFICE, LIBRARY OF CONGRESS COPYRIGHT... and terms for the making of digital phonorecord deliveries during the periods beginning January 1... new rates and terms for the making of digital phonorecord deliveries during the periods beginning...

  19. 37 CFR 255.7 - Future proceedings.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Section 255.7 Patents, Trademarks, and Copyrights COPYRIGHT OFFICE, LIBRARY OF CONGRESS COPYRIGHT... and terms for the making of digital phonorecord deliveries during the periods beginning January 1... new rates and terms for the making of digital phonorecord deliveries during the periods beginning...

  20. 37 CFR 251.62 - Content of petition.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Content of petition. 251.62 Section 251.62 Patents, Trademarks, and Copyrights COPYRIGHT OFFICE, LIBRARY OF CONGRESS COPYRIGHT... proceedings for cable, ephemeral recordings, certain digital audio transmissions, phonorecords, digital...

  1. 37 CFR 255.7 - Future proceedings.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Section 255.7 Patents, Trademarks, and Copyrights COPYRIGHT OFFICE, LIBRARY OF CONGRESS COPYRIGHT... and terms for the making of digital phonorecord deliveries during the periods beginning January 1... new rates and terms for the making of digital phonorecord deliveries during the periods beginning...

  2. 37 CFR 255.7 - Future proceedings.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Section 255.7 Patents, Trademarks, and Copyrights COPYRIGHT OFFICE, LIBRARY OF CONGRESS COPYRIGHT... and terms for the making of digital phonorecord deliveries during the periods beginning January 1... new rates and terms for the making of digital phonorecord deliveries during the periods beginning...

  3. 37 CFR 251.62 - Content of petition.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2011-07-01 2011-07-01 false Content of petition. 251.62 Section 251.62 Patents, Trademarks, and Copyrights COPYRIGHT OFFICE, LIBRARY OF CONGRESS COPYRIGHT... proceedings for cable, ephemeral recordings, certain digital audio transmissions, phonorecords, digital...

  4. Hearing Sensation Levels of Emitted Biosonar Clicks in an Echolocating Atlantic Bottlenose Dolphin

    PubMed Central

    Li, Songhai; Nachtigall, Paul E.; Breese, Marlee; Supin, Alexander Ya.

    2012-01-01

    Emitted biosonar clicks and auditory evoked potential (AEP) responses triggered by the clicks were synchronously recorded during echolocation in an Atlantic bottlenose dolphin (Tursiops truncatus) trained to wear suction-cup EEG electrodes and to detect targets by echolocation. Three targets with target strengths of −34, −28, and −22 dB were used at distances of 2 to 6.5 m for each target. The AEP responses were sorted according to the corresponding emitted click source levels in 5-dB bins and averaged within each bin to extract biosonar click-related AEPs from noise. The AEP amplitudes were measured peak-to-peak and plotted as a function of click source levels for each target type, distance, and target-present or target-absent condition. Hearing sensation levels of the biosonar clicks were evaluated by comparing the functions of the biosonar click-related AEP amplitude-versus-click source level to a function of external (in free field) click-related AEP amplitude-versus-click sound pressure level. The results indicated that the dolphin's hearing sensation levels to her own biosonar clicks were equal to that of external clicks with sound pressure levels 16 to 36 dB lower than the biosonar click source levels, varying with target type, distance, and condition. These data may be assumed to indicate that the bottlenose dolphin possesses effective protection mechanisms to isolate the self-produced intense biosonar beam from the animal's ears during echolocation. PMID:22238654

  5. Hearing sensation levels of emitted biosonar clicks in an echolocating Atlantic bottlenose dolphin.

    PubMed

    Li, Songhai; Nachtigall, Paul E; Breese, Marlee; Supin, Alexander Ya

    2012-01-01

    Emitted biosonar clicks and auditory evoked potential (AEP) responses triggered by the clicks were synchronously recorded during echolocation in an Atlantic bottlenose dolphin (Tursiops truncatus) trained to wear suction-cup EEG electrodes and to detect targets by echolocation. Three targets with target strengths of -34, -28, and -22 dB were used at distances of 2 to 6.5 m for each target. The AEP responses were sorted according to the corresponding emitted click source levels in 5-dB bins and averaged within each bin to extract biosonar click-related AEPs from noise. The AEP amplitudes were measured peak-to-peak and plotted as a function of click source levels for each target type, distance, and target-present or target-absent condition. Hearing sensation levels of the biosonar clicks were evaluated by comparing the functions of the biosonar click-related AEP amplitude-versus-click source level to a function of external (in free field) click-related AEP amplitude-versus-click sound pressure level. The results indicated that the dolphin's hearing sensation levels to her own biosonar clicks were equal to that of external clicks with sound pressure levels 16 to 36 dB lower than the biosonar click source levels, varying with target type, distance, and condition. These data may be assumed to indicate that the bottlenose dolphin possesses effective protection mechanisms to isolate the self-produced intense biosonar beam from the animal's ears during echolocation.

  6. Proceedings of Colloquium 110 of the International Astronomical Union on Library and Information Services in Astronomy

    NASA Astrophysics Data System (ADS)

    Wilkins, George A.; Stevens-Rayburn, Sarah

    This report provides an overview of the presentations and summaries of discussions at IAU Colloquium 110, which was held in Washington, D.C., on 26-30 July 1988 and at the Goddard Space Flight Center on 1 August 1988. The topics included: the publication and acquisition of books and journals; searching for astronomical information; the handling and use of special-format materials; conservation; archiving of unpublished documents; uses of computers in libraries; astronomical databases and various aspects of the administration of astronomy libraries and services. Particular attention was paid to new developments, but the problems of astronomers and institutions in developing countries were also considered.

  7. Evoked-potential recovery during double click stimulation in a whale: a possibility of biosonar automatic gain control.

    PubMed

    Supin, Alexander Ya; Nachtigall, Paul E; Breese, Marlee

    2007-01-01

    False killer whale Pseudorca crassidens auditory brainstem responses (ABR) were recorded using a double-click stimulation paradigm specifically measuring the recovery of the second response (to the test click) as a function of the inter-click interval (ICI) at various levels of the conditioning and test click. At all click intensities, the slopes of recovery functions were almost constant: 0.6-0.8 microV per ICI decade. Therefore, even when the conditioning-to-test-click level ratio was kept constant, the duration of recovery was intensity-dependent: The higher intensity the longer the recovery. The conditioning-to-test-click level ratio strongly influenced the recovery time: The higher the ratio, the longer the recovery. The dependence was almost linear using a logarithmic ICI scale with a rate of 25-30 dB per ICI decade. These data were used for modeling the interaction between the emitted click and the echo during echolocation, assuming that the two clicks simulated the transmitted and echo clicks. This simulation showed that partial masking of the echo by the preceding emitted click may explain the independence of echo-response amplitude of target distance. However, the distance range where this mechanism is effective depends on the emitted click level: The higher the level, the greater the range. @ 2007 Acoustical Society of America.

  8. 76 FR 54768 - Notice of Suspension and Commencement of Proposed Debarment Proceedings; Schools and Libraries...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-02

    ... at http://www.fcc.gov . The text may also be purchased from the Commission's duplicating inspection... exchange, you and a co-conspirator paid the school official $79,382 in bribes and kickbacks for steering E...

  9. 37 CFR 255.7 - Future proceedings.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Section 255.7 Patents, Trademarks, and Copyrights U.S. COPYRIGHT OFFICE, LIBRARY OF CONGRESS COPYRIGHT... and terms for the making of digital phonorecord deliveries during the periods beginning January 1... new rates and terms for the making of digital phonorecord deliveries during the periods beginning...

  10. 37 CFR 385.17 - Effect of rates.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Section 385.17 Patents, Trademarks, and Copyrights COPYRIGHT ROYALTY BOARD, LIBRARY OF CONGRESS RATES AND... MAKING AND DISTRIBUTING OF PHYSICAL AND DIGITAL PHONORECORDS Interactive Streaming, Other Incidental Digital Phonorecord Deliveries and Limited Downloads § 385.17 Effect of rates. In any future proceedings...

  11. 37 CFR 385.17 - Effect of rates.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Section 385.17 Patents, Trademarks, and Copyrights COPYRIGHT ROYALTY BOARD, LIBRARY OF CONGRESS RATES AND... MAKING AND DISTRIBUTING OF PHYSICAL AND DIGITAL PHONORECORDS Interactive Streaming, Other Incidental Digital Phonorecord Deliveries and Limited Downloads § 385.17 Effect of rates. In any future proceedings...

  12. 37 CFR 385.17 - Effect of rates.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Section 385.17 Patents, Trademarks, and Copyrights COPYRIGHT ROYALTY BOARD, LIBRARY OF CONGRESS RATES AND... MAKING AND DISTRIBUTING OF PHYSICAL AND DIGITAL PHONORECORDS Interactive Streaming, Other Incidental Digital Phonorecord Deliveries and Limited Downloads § 385.17 Effect of rates. In any future proceedings...

  13. 37 CFR 385.17 - Effect of rates.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Section 385.17 Patents, Trademarks, and Copyrights COPYRIGHT ROYALTY BOARD, LIBRARY OF CONGRESS RATES AND... MAKING AND DISTRIBUTING OF PHYSICAL AND DIGITAL PHONORECORDS Interactive Streaming, Other Incidental Digital Phonorecord Deliveries and Limited Downloads § 385.17 Effect of rates. In any future proceedings...

  14. Proceedings of the Conference on Behavior Representation in Modeling and Simulation (19th), held in Charleston, South Carolina, 21 - 24 March 2010

    DTIC Science & Technology

    2010-03-01

    user performance .” “Wonderful. I can clearly see how, as a practitioner in industry , I can apply this to the numerous projects I work on.” Proceedings...CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING ...effects on performance ), libraries of basic human operator procedures (how-to knowledge) and geometries for building scenarios graphically (that

  15. Proceedings of a Workshop on Composite Material Response: Constitutive Relations and Damage Mechanisms Held in Glasgow, United Kingdom on July 30-31, 1987

    DTIC Science & Technology

    1987-07-01

    Grosvenor Hotel, Glasgow, UK, July 30th and 31st 1987. COMPOSITE MATERIAL RESPONSE: CONSTITUTIVE RELATIONS AND DAMAGE MECHANISMS Edited by G. C . SIH...Cataloguing in Publication Data Composite material response. I. Composite materials I. Sib, G. C . (George C .) 620.l’l 8 ISBN 1-85166-228-6 Library of...Strathclyde) Composite material response: constitutive relations and damage mechanisms/edited by G. C . Sih ... [et al.]. p. cm. "Proceedings of a Workshop on

  16. Neural representation of the self-heard biosonar click in bottlenose dolphins (Tursiops truncatus).

    PubMed

    Finneran, James J; Mulsow, Jason; Houser, Dorian S; Schlundt, Carolyn E

    2017-05-01

    The neural representation of the dolphin broadband biosonar click was investigated by measuring auditory brainstem responses (ABRs) to "self-heard" clicks masked with noise bursts having various high-pass cutoff frequencies. Narrowband ABRs were obtained by sequentially subtracting responses obtained with noise having lower high-pass cutoff frequencies from those obtained with noise having higher cutoff frequencies. For comparison to the biosonar data, ABRs were also measured in a passive listening experiment, where external clicks and masking noise were presented to the dolphins and narrowband ABRs were again derived using the subtractive high-pass noise technique. The results showed little change in the peak latencies of the ABR to the self-heard click from 28 to 113 kHz; i.e., the high-frequency neural responses to the self-heard click were delayed relative to those of an external, spectrally "pink" click. The neural representation of the self-heard click is thus highly synchronous across the echolocation frequencies and does not strongly resemble that of a frequency modulated downsweep (i.e., decreasing-frequency chirp). Longer ABR latencies at higher frequencies are hypothesized to arise from spectral differences between self-heard clicks and external clicks, forward masking from previously emitted biosonar clicks, or neural inhibition accompanying the emission of clicks.

  17. Neural representation of the self-heard biosonar click in bottlenose dolphins (Tursiops truncatus)

    PubMed Central

    Finneran, James J.; Mulsow, Jason; Houser, Dorian S.; Schlundt, Carolyn E.

    2017-01-01

    The neural representation of the dolphin broadband biosonar click was investigated by measuring auditory brainstem responses (ABRs) to “self-heard” clicks masked with noise bursts having various high-pass cutoff frequencies. Narrowband ABRs were obtained by sequentially subtracting responses obtained with noise having lower high-pass cutoff frequencies from those obtained with noise having higher cutoff frequencies. For comparison to the biosonar data, ABRs were also measured in a passive listening experiment, where external clicks and masking noise were presented to the dolphins and narrowband ABRs were again derived using the subtractive high-pass noise technique. The results showed little change in the peak latencies of the ABR to the self-heard click from 28 to 113 kHz; i.e., the high-frequency neural responses to the self-heard click were delayed relative to those of an external, spectrally “pink” click. The neural representation of the self-heard click is thus highly synchronous across the echolocation frequencies and does not strongly resemble that of a frequency modulated downsweep (i.e., decreasing-frequency chirp). Longer ABR latencies at higher frequencies are hypothesized to arise from spectral differences between self-heard clicks and external clicks, forward masking from previously emitted biosonar clicks, or neural inhibition accompanying the emission of clicks. PMID:28599518

  18. Advanced data acquisition and display techniques for laser velocimetry

    NASA Technical Reports Server (NTRS)

    Kjelgaard, Scott O.; Weston, Robert P.

    1991-01-01

    The Basic Aerodynamics Research Tunnel (BART) has been equipped with state-of-the-art instrumentation for acquiring the data needed for code validation. This paper describes the three-component LDV and the workstation-based data-acquisition system (DAS) which has been developed for the BART. The DAS allows the use of automation and the quick integration of advanced instrumentation, while minimizing the software development time required between investigations. The paper also includes a description of a graphics software library developed to support the windowing environment of the DAS. The real-time displays generated using the graphics library help the researcher ensure the test is proceeding properly. The graphics library also supports the requirements of posttest data analysis. The use of the DAS and graphics libraries is illustrated by presenting examples of the real-time and postprocessing display graphics for LDV investigations.

  19. The ZeroAccess Auto-Clicking and Search-Hijacking Click Fraud Modules

    DTIC Science & Technology

    2013-12-16

    payloads and instead began distributing Bitcoin miners and click fraud modules.3 From a technical perspective, the primary click fraud malware used in...this era operated in the indiscriminate “auto-clicking” fashion we describe in Section 5. Alongside the click fraud and Bitcoin payloads, ZeroAccess

  20. Echolocation-Based Foraging by Harbor Porpoises and Sperm Whales, Including Effects on Noise and Acoustic Propagation

    DTIC Science & Technology

    2008-09-01

    Behavioural Point Process Data 234 Appendix B: Matlab Code 258 Matlab Code Used in Chapter 2 (Porpoise Prey Capture Analysis) 258 Click Extraction and...Measurement of Click Properties 258 Envelope-based Click Detector 262 Matlab Code Used in Chapter 3 (Transmission Loss in Porpoise Habitats) ..267...Click Extraction from Data Wavefiles 267 Click Level Determination (Grand Manan Datasets) 270 Click Level Determination (Danish Datasets) 287 Matlab

  1. Precision synthesis of functional materials via RAFT polymerization and click-type chemical reactions

    NASA Astrophysics Data System (ADS)

    Flores, Joel Diez

    2011-12-01

    The need to tailor polymeric architectures with specific physico-chemical properties via the simplest, cleanest, and most efficient synthetic route possible has become the ultimate goal in polymer synthesis. Recent progress in macromolecular science, such as the discoveries of controlled/"living" free radical polymerization (CRP) methods, has brought about synthetic capabilities to prepare (co)polymers with advanced topologies, predetermined molecular weights, narrow molecular weight distributions, and precisely located functional groups. In addition, the establishment of click chemistry has redefined the selected few highly efficient chemical reactions that become highly useful in post-polymerization modification strategies. Hence, the ability to make well-defined topologies afforded by controlled polymerization techniques and the facile incorporation of functionalities along the chain via click-type reactions have yielded complex architectures, allowing the investigation of physical phenomena which otherwise could not be studied with systems prepared via conventional methods. The overarching theme of the research work described in this dissertation is the fusion of the excellent attributes of reversible addition-fragmentation chain transfer (RAFT) polymerization method, which is one of the CRP techniques, and click-type chemical reactions in the precision of synthesis of advanced functional materials. Chapter IV is divided into three sections. In Section I, the direct RAFT homopolymerization of 2-(acryloyloxy)ethyl isocyanate (AOI) and subsequent post-polymerization modifications are described. The polymerization conditions were optimized in terms of the choice of RAFT chain transfer agent (CTA), polymerization temperature and the reaction medium. Direct RAFT polymerization of AOI requires a neutral CTA, and relatively low reaction temperature to yield AOI homopolymers with low polydispersities. Efficient side-chain functionalization of PAOI homopolymers was achieved via reaction with model amine, thiol and alcohol compounds yielding urea, thiourethane and urethane derivatives, respectively. Reactions with amines and thiols (in the presence of base) were rapid, quantitative and efficient. However, the reaction with alcohols catalyzed by dibutyltin dilaurate (DBTDL) was relatively slow but proceeded to completion. Selective reaction pathways for the addition of difunctional ethanolamine and mercaptoethanol were also investigated. A related strategy is described in Section II wherein a hydroxyl-containing diblock copolymer precursor was transformed into a library of functional copolymers via two sequential post-polymerization modification reactions. A diblock copolymer scaffold, poly[(N,N-dimethylacrylamide)-b-( N-(2-hydroxyethyl)acrylamide] (PDMA-b-PHEA) was first prepared. The hydroxyl groups of the HEA block were then reacted with 2-(acryloyloxy)ethylisocyanate (AOI) and allylisocyanate (AI) resulting in acrylate- and allyl-functionalized copolymer precursors, respectively. The efficiencies of Michael-type and free radical thiol addition reactions were investigated using selected thiols having alkyl, aryl, hydroxyl, carboxylic acid, amine and amino acid functionalities. The steps of RAFT polymerization, isocyanate-hydroxyl coupling and thiol-ene addition are accomplished under mild conditions, thus offering facile and modular routes to synthesize functional copolymers. The synthesis and solution studies of pH- and salt-responsive triblock copolymer are described in Section III. This system is capable of forming self-locked micellar structures which may be controlled by changing solution pH as well as ionic strength. A triblock copolymer containing a permanently hydrophilic poly(N,N-dimethylacrylamide) (PDMA) outer block, a salt-sensitive zwitterionic poly(3[2-(N-methylacrylamido)ethyl dimethylammonio]propanesulfonate) (PMAEDAPS) middle block and a pH-responsive 3-acrylamido-3-methylbutanoic acid (PAMBA) core block was synthesized using aqueous RAFT polymerization. A facile formation of "self-locking" shell cross-linked micelles is achieved by changing solution pH and salt concentration. The reversible "self-locking" is attained from the interactions of zwitterionic groups in the middle block that constitutes the shell of the micelles. The structure slowly dissociates into unimers in 2-3 days at pH above the pKa of the PAMBA block.

  2. National Centers for Environmental Prediction

    Science.gov Websites

    NAM Specifications/References [<--click here] Rapid Refresh (RAP) [<--click here] High -Resolution Rapid Refresh (HRRR) [<--click here] Short-range Ensemble Forecast (SREF) system [<--click

  3. 37 CFR 251.71 - Commencement of proceedings.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    .... 251.71 Section 251.71 Patents, Trademarks, and Copyrights COPYRIGHT OFFICE, LIBRARY OF CONGRESS... year in accordance with the requirements of this subchapter. (c) Digital audio recording devices and... manufacture and distribution in the United States, of any digital recording device or medium, any person...

  4. 37 CFR 251.71 - Commencement of proceedings.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    .... 251.71 Section 251.71 Patents, Trademarks, and Copyrights COPYRIGHT OFFICE, LIBRARY OF CONGRESS... year in accordance with the requirements of this subchapter. (c) Digital audio recording devices and... manufacture and distribution in the United States, of any digital recording device or medium, any person...

  5. Stereotypical rapid source level regulation in the harbour porpoise biosonar

    NASA Astrophysics Data System (ADS)

    Linnenschmidt, Meike; Kloepper, Laura N.; Wahlberg, Magnus; Nachtigall, Paul E.

    2012-09-01

    Some odontocetes and bats vary both click intensity and receiver sensitivity during echolocation, depending on target range. It is not known how this so-called automatic gain control is regulated by the animal. The source level of consecutive echolocation clicks from a harbour porpoise was measured with a hydrophone array while the animal detected an aluminium cylinder at 2, 4 or 8 m distance in a go/no-go paradigm. On-axis clicks had source levels of 145-174 dB re 1 μPa peak-to-peak. During target-present trials the click trains reached comparable source levels independent of the range to the target after three clicks. After an additional click, the source level was reduced for the 2 and 4 m trials until it equalled the one-way transmission loss. During target-absent trials, the source level remained high throughout the entire click train. Given typical values of harbour porpoise inter-click intervals, the source level reduction commenced within a few 100 ms from the first click in the click train. This may indicate a sub-cortically regulated source level regulation in the harbour porpoise.

  6. Dual mechanisms in the perceptual processing of click train temporal regularity.

    PubMed

    Phillips, Dennis P; Dingle, Rachel N; Hall, Susan E; Jang, Moragh

    2012-07-01

    Two experiments measured human sensitivity to temporal jitter in 25-click trains with inter-click intervals (ICIs) between 5 and 100 ms. In a naturalistic experiment using wideband clicks, jitter thresholds were a nonmonotonic function of ICI, peaking for ICIs near 40-60 ms. In a subsequent experiment, clicks were high-passed and presented against a low-frequency noise masker. Jitter threshold vs ICI functions lost the positive slope over short ICIs but retained the negative slope at long ICIs. The same behavior was seen in click rate discrimination tasks. Different processes mediate regularity analysis for click trains with ICIs above and below 40-60 ms.

  7. WPC Maximum Heat Index Forecasts

    Science.gov Websites

    Forecasts for Western US CLICK ON MAPS FOR MAXIMUM HEAT INDEX AND PROBABILITY FORECASTS FROM SUN MAY 27 2018 02 CLICK to view SAT JUN 02 forecast SUN JUN 03 CLICK to view SUN JUN 03 forecast SUN JUN 03 CLICK to view SUN JUN 03 forecast SUN JUN 03 CLICK to view SUN JUN 03 forecast SUN JUN 03 CLICK to view SUN JUN

  8. Assessing the biocompatibility of click-linked DNA in Escherichia coli

    PubMed Central

    Sanzone, A. Pia; El-Sagheer, Afaf H.; Brown, Tom; Tavassoli, Ali

    2012-01-01

    The biocompatibility of a triazole mimic of the DNA phosphodiester linkage in Escherichia coli has been evaluated. The requirement for selective pressure on the click-containing gene was probed via a plasmid containing click DNA backbone linkages in each strand of the gene encoding the fluorescent protein mCherry. The effect of proximity of the click linkers on their biocompatibility was also probed by placing two click DNA linkers 4-bp apart at the region encoding the fluorophore of the fluorescent protein. The resulting click-containing plasmid was found to encode mCherry in E. coli at a similar level to the canonical equivalent. The ability of the cellular machinery to read through click-linked DNA was further probed by using the above click-linked plasmid to express mCherry using an in vitro transcription/translation system, and found to also be similar to that from canonical DNA. The yield and fluorescence of recombinant mCherry expressed from the click-linked plasmid was also compared to that from the canonical equivalent, and found to be the same. The biocompatibility of click DNA ligation sites at close proximity in a non-essential gene demonstrated in E. coli suggests the possibility of using click DNA ligation for the enzyme-free assembly of chemically modified genes and genomes. PMID:22904087

  9. What clicks actually mean: Exploring digital news user practices.

    PubMed

    Kormelink, Tim Groot; Meijer, Irene Costera

    2018-05-01

    This article problematizes the relationship between clicks and audience interests. Clicking patterns are often seen as evidence that news users are mostly interested in junk news, leading to concerns about the state of journalism and the implications for society. Asking and observing how 56 users actually browse news and what clicking and not clicking mean to them, we identified 30 distinct considerations for (not) clicking and classified them into three categories: cognitive, affective and pragmatic. The results suggest, first, that interest is too crude a term to account for the variety of people's considerations for (not) clicking. Second, even if one aims for roughly estimating people's news interests, clicks are a flawed instrument because a lack of clicking does not measure people's lack of interest in news. Third, taking users' browsing patterns seriously could help bridge the gap between what people need as citizens and what they actually consume. Finally, we argue that all metrics should be critically assessed from a user perspective rather than taken at face value.

  10. What clicks actually mean: Exploring digital news user practices

    PubMed Central

    Kormelink, Tim Groot; Meijer, Irene Costera

    2017-01-01

    This article problematizes the relationship between clicks and audience interests. Clicking patterns are often seen as evidence that news users are mostly interested in junk news, leading to concerns about the state of journalism and the implications for society. Asking and observing how 56 users actually browse news and what clicking and not clicking mean to them, we identified 30 distinct considerations for (not) clicking and classified them into three categories: cognitive, affective and pragmatic. The results suggest, first, that interest is too crude a term to account for the variety of people’s considerations for (not) clicking. Second, even if one aims for roughly estimating people’s news interests, clicks are a flawed instrument because a lack of clicking does not measure people’s lack of interest in news. Third, taking users’ browsing patterns seriously could help bridge the gap between what people need as citizens and what they actually consume. Finally, we argue that all metrics should be critically assessed from a user perspective rather than taken at face value. PMID:29782573

  11. 37 CFR 353.5 - Participation not required.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    .... 353.5 Section 353.5 Patents, Trademarks, and Copyrights COPYRIGHT ROYALTY BOARD, LIBRARY OF CONGRESS COPYRIGHT ROYALTY JUDGES RULES AND PROCEDURES REHEARING § 353.5 Participation not required. In any case in... inference from a lack of participation in a rehearing. Nonparticipation in rehearing proceedings may limit...

  12. 37 CFR 353.5 - Participation not required.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    .... 353.5 Section 353.5 Patents, Trademarks, and Copyrights COPYRIGHT ROYALTY BOARD, LIBRARY OF CONGRESS COPYRIGHT ROYALTY JUDGES RULES AND PROCEDURES REHEARING § 353.5 Participation not required. In any case in... inference from a lack of participation in a rehearing. Nonparticipation in rehearing proceedings may limit...

  13. Global Complexity: Information, Chaos, and Control at ASIS 1996 Annual Meeting.

    ERIC Educational Resources Information Center

    Jacob, M. E. L.

    1996-01-01

    Discusses proceedings of the 1996 ASIS (American Society for Information Science) annual meeting in Baltimore (Maryland), including chaos theory; electronic universities; distance education; intellectual property, including information privacy on the Internet; the need for leadership in libraries and information centers; information warfare and…

  14. Stereotypical rapid source level regulation in the harbour porpoise biosonar.

    PubMed

    Linnenschmidt, Meike; Kloepper, Laura N; Wahlberg, Magnus; Nachtigall, Paul E

    2012-09-01

    Some odontocetes and bats vary both click intensity and receiver sensitivity during echolocation, depending on target range. It is not known how this so-called automatic gain control is regulated by the animal. The source level of consecutive echolocation clicks from a harbour porpoise was measured with a hydrophone array while the animal detected an aluminium cylinder at 2, 4 or 8 m distance in a go/no-go paradigm. On-axis clicks had source levels of 145-174 dB re 1 μPa peak-to-peak. During target-present trials the click trains reached comparable source levels independent of the range to the target after three clicks. After an additional click, the source level was reduced for the 2 and 4 m trials until it equalled the one-way transmission loss. During target-absent trials, the source level remained high throughout the entire click train. Given typical values of harbour porpoise inter-click intervals, the source level reduction commenced within a few 100 ms from the first click in the click train. This may indicate a sub-cortically regulated source level regulation in the harbour porpoise.

  15. A diversity-oriented synthesis strategy enabling the combinatorial-type variation of macrocyclic peptidomimetic scaffolds† †Electronic supplementary information (ESI) available: Experimental procedures, characterization data and details of the computational analyses. See DOI: 10.1039/c5ob00371g Click here for additional data file.

    PubMed Central

    Isidro-Llobet, Albert; Hadje Georgiou, Kathy; Galloway, Warren R. J. D.; Giacomini, Elisa; Hansen, Mette R.; Méndez-Abt, Gabriela; Tan, Yaw Sing; Carro, Laura; Sore, Hannah F.

    2015-01-01

    Macrocyclic peptidomimetics are associated with a broad range of biological activities. However, despite such potentially valuable properties, the macrocyclic peptidomimetic structural class is generally considered as being poorly explored within drug discovery. This has been attributed to the lack of general methods for producing collections of macrocyclic peptidomimetics with high levels of structural, and thus shape, diversity. In particular, there is a lack of scaffold diversity in current macrocyclic peptidomimetic libraries; indeed, the efficient construction of diverse molecular scaffolds presents a formidable general challenge to the synthetic chemist. Herein we describe a new, advanced strategy for the diversity-oriented synthesis (DOS) of macrocyclic peptidomimetics that enables the combinatorial variation of molecular scaffolds (core macrocyclic ring architectures). The generality and robustness of this DOS strategy is demonstrated by the step-efficient synthesis of a structurally diverse library of over 200 macrocyclic peptidomimetic compounds, each based around a distinct molecular scaffold and isolated in milligram quantities, from readily available building-blocks. To the best of our knowledge this represents an unprecedented level of scaffold diversity in a synthetically derived library of macrocyclic peptidomimetics. Cheminformatic analysis indicated that the library compounds access regions of chemical space that are distinct from those addressed by top-selling brand-name drugs and macrocyclic natural products, illustrating the value of our DOS approach to sample regions of chemical space underexploited in current drug discovery efforts. An analysis of three-dimensional molecular shapes illustrated that the DOS library has a relatively high level of shape diversity. PMID:25778821

  16. Library of Antifouling Surfaces Derived From Natural Amino Acids by Click Reaction.

    PubMed

    Xu, Chen; Hu, Xin; Wang, Jie; Zhang, Ye-Min; Liu, Xiao-Jiu; Xie, Bin-Bin; Yao, Chen; Li, Yi; Li, Xin-Song

    2015-08-12

    Biofouling is of great concern in numerous applications ranging from ophthalmological implants to catheters, and from bioseparation to biosensors. In this report, a general and facile strategy to combat surface fouling is developed by grafting of amino acids onto polymer substrates to form zwitterionic structure through amino groups induced epoxy ring opening click reaction. First of all, a library of poly(2-hydroxyethyl methacrylate-co-glycidyl methacrylate) hydrogels with zwitterionic surfaces were prepared, resulting in the formation of pairs of carboxyl anions and protonated secondary amino cations. The analysis of attenuated total reflectance Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy confirmed the successful immobilization of amino acids on the hydrogel surfaces. After that, the contact angle and equilibrium water content of the modified hydrogels showed that the hydrogels exhibited improved hydrophilicity compared with the parent hydrogel. Furthermore, the protein deposition was evaluated by bicinchoninic acid assay using bovine serum albumin (BSA) and lysozyme as models. The results indicated that the performance of the hydrogels was determined by the nature of incorporated amino acid: the hydrogels incorporated with neutral amino acids had nonspecific antiadsorption capability to both BSA and lysozyme; the hydrogels incorporated with charged amino acids showed antiadsorption behaviors against protein with same charge and enhanced adsorption to the protein with opposite charge; the optimal antiadsorption performance was observed on the hydrogels incorporated with polar amino acids with a hydroxyl residual. The improvement of antiprotein fouling of the neutral amino acids grafted hydrogels can be ascribed to the formation of zwitterionic surfaces. Finally, a couple of soft contact lenses grafted with amino acids were fabricated having improved antifouling property and hydrophilicity. The result demonstrated the success of amino acids based zwitterionic antifouling strategy in ophthalmology. This strategy is also applicable to substrates including filtration membranes, microspheres and nanofibers as well. It is a versatile method for amino acids grafting onto polymer substrates to construct zwitterionic surfaces and achieve antifouling properties.

  17. Middle ear myoclonus associated with forced eyelid closure in children: diagnosis and treatment outcome.

    PubMed

    Lee, Guen-Ho; Bae, Seong-Cheon; Jin, Sang-Gyun; Park, Kyoung-Ho; Yeo, Sang-Won; Park, Shi-Nae

    2012-09-01

    Forceful eyelid closure syndrome (FECS) was first reported at the Proceedings of the Second International Tinnitus Seminar in 1983. The main symptom of this syndrome is a spontaneous muscular tinnitus related only to forced eye closure, specifically the voluntary contraction of the periorbital muscles. Although investigation of the syndrome was initiated >100 years ago, only four cases have been published in the past 20 years. We report six cases of middle ear myoclonus tinnitus diagnosed as FECS in children and discuss issues surrounding the diagnosis and treatment of this syndrome. Retrospective case series. From 2009 to 2011, six children complaining of clicking or crackling sounds in their ears presented at Seoul St. Mary's Hospital. Endoscopic examination and recording of the tympanic membrane were performed while the patients were asked to close their eyes forcefully. Audiologic studies including acoustic reflex decay and static compliance were performed for documentation of the movement of the tympanic membrane. Triggering factors of FECS in the children were carefully evaluated. Synchronous movement of the tympanic membrane in response to forced eye closure on endoscopic examination was the most reliable finding to diagnose FECS. Acoustic reflex decay and other impedance audiogram findings showed irregular perturbations during forced eye closure, which led to diagnosis of the tinnitus as middle ear myoclonus. Most of the patients had triggering factors for FECS. Reassurance and removal of the triggering or causal factors with or without medication improved clicking sounds coming from middle ear myoclonus. FECS is a rare clinical entity and can be easily missed in routine clinical examination. We suggest that patients, especially children, with clicking or crackling tinnitus should be evaluated for FECS using proper diagnostic tools. A possible mechanism of FECS in children postulated from our case review is suggested. Copyright © 2012 The American Laryngological, Rhinological, and Otological Society, Inc.

  18. Record of Current Educational Publications. Bulletin, 1929, No. 33

    ERIC Educational Resources Information Center

    Office of Education, United States Department of the Interior, 1929

    1929-01-01

    This bulletin provides an annotated, classified bibliography of books, articles from periodicals, reports, surveys, proceedings of associations, and investigations and research into present educational conditions received by the library of the Office of Education during the first six months of 1929, January to June, inclusive. An index will be…

  19. Effectiveness of Health Promotion Programmes for Truck Drivers: A Systematic Review

    ERIC Educational Resources Information Center

    Ng, Mandy K.; Yousuf, Bilal; Bigelow, Philip Lloyd; Van Eerd, Dwayne

    2015-01-01

    Objective: To review the characteristics of effective health promotion interventions for reducing chronic diseases and their risk factors in truck drivers. Methods: MEDLINE (PubMed), SCOPUS, Web of Science Conference Proceedings, CINAHL (Cumulative Index to Nursing and Allied Health Literature), and the National Transportation Library were…

  20. 37 CFR 351.12 - Closing the record.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Closing the record. 351.12 Section 351.12 Patents, Trademarks, and Copyrights COPYRIGHT ROYALTY BOARD, LIBRARY OF CONGRESS COPYRIGHT ROYALTY JUDGES RULES AND PROCEDURES PROCEEDINGS § 351.12 Closing the record. To close the record of a...

  1. Proceedings, Resource Sharing II, 22nd Military Librarians Workshop

    DTIC Science & Technology

    1979-01-01

    nation Provide adequate trained personnel for the varied and changing Vi demands of librarianship 3 To satisfy these objectives, which can only be met...scholarly research and to library reference work. This ’new’ reference service is seen by some as a revolution in professional librarianship and by others

  2. 76 FR 71006 - Combined Notice of Filings #1

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-16

    .... Applicants: PJM Interconnection, LLC. Description: Queue Position W2-040; Original Service Agreement No. 3097... Date: 5 p.m. ET on 11/28/2011. The filings are accessible in the Commission's eLibrary system by... the above proceedings must file in accordance with Rules 211 and 214 of the Commission's Regulations...

  3. 37 CFR 251.32 - Financial disclosure statement.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... nomination, each nominated arbitrator shall file with the Librarian of Congress a confidential financial... Librarian and designated Library staff to determine what conflicts of interest, if any, exist according to § 251.31. (b) If any conflicts do exist, the Librarian shall not choose that person for the proceeding...

  4. Seminar on Cataloguing (1970): Working Paper and Proceedings.

    ERIC Educational Resources Information Center

    Documentation Research and Training Centre, Bangalore (India).

    The publication includes papers from the opening session, eighteen working papers on library cataloging, eighteen papers presented at group meetings and plenary sessions, and papers from the concluding session. The inaugural address "Cataloging Enters the Spiral of Scientific Method" was presented by S.R. Ranganathan. The working paper…

  5. Horseradish-Peroxidase-Catalyzed Tyrosine Click Reaction.

    PubMed

    Sato, Shinichi; Nakamura, Kosuke; Nakamura, Hiroyuki

    2017-03-02

    The efficiency of protein chemical modification on tyrosine residues with N-methylluminol derivatives was drastically improved by using horseradish peroxidase (HRP). In the previous method, based on the use of hemin and H 2 O 2 , oxidative side reactions such as cysteine oxidation were problematic for functionalization of proteins selectively on tyrosine residues. Oxidative activation of N-methylluminol derivatives with a minimum amount of H 2 O 2 prevented the occurrence of oxidative side reactions under HRP-catalyzed conditions. As probes for HRP-catalyzed protein modification, N-methylluminol derivatives showed much higher efficiency than tyramide without inducing oligomerization of probe molecules. Tyrosine modification also proceeded in the presence of β-nicotinamide adenine dinucleotide (NADH, H 2 O 2 -free conditions). © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  6. Click chemistry in the Development of Contrast Agents for Magnetic Resonance Imaging

    PubMed Central

    Hapuarachchige, Sudath; Artemov, Dmitri

    2016-01-01

    Click chemistry provides fast, convenient, versatile and reliable chemical reactions that take place between pairs of functional groups of small molecules that can be purified without chromatographic methods. Due to the fast kinetics and low or no elimination of byproducts, click chemistry is a promising approach that is rapidly gaining acceptance in drug discovery, radiochemistry, bioconjugation, and nanoscience applications. Increasing use of click chemistry in synthetic procedures or as a bioconjugation technique in diagnostic imaging is occurring because click reactions are fast, provide a quantitative yield, and produce minimal amount of nontoxic byproducts. This review summarizes the recent application of click chemistry in magnetic resonance imaging and discusses the directions for applying novel click reactions and strategies for further improving MRI performance. PMID:27748712

  7. Effect of Broadband Nature of Marine Mammal Echolocation Clicks on Click-Based Population Density Estimates

    DTIC Science & Technology

    2014-09-30

    initially on beaked whales (Blainville’s or Cuvier’s), for which high quality click recordings of clicks are available from DTAG data, as these are known...will be applied also to other species such as sperm whale (Physeter macrocephalus) (whose high source level assures long range detection and amplifies...REFERENCES Gillespie, D. and Leaper, R. (1996). Detection of sperm whale Physeter macrocephalus clicks and discrimination of individual vocalizations

  8. Effect of Broadband Nature of Marine Mammal Echolocation Clicks on Click-Based Population Density Estimates

    DTIC Science & Technology

    2014-09-30

    research will focus initially on beaked whales (Blainville’s or Cuvier’s), for which high quality click recordings of clicks are available from DTAG...The same methodology will be applied also to other species such as sperm whale (Physeter macrocephalus) (whose high source level assures long range...Thomas, University of St. Andrews). REFERENCES Gillespie, D. and Leaper, R. (1996). Detection of sperm whale Physeter macrocephalus clicks and

  9. Information sources in science and technology in Finland

    NASA Technical Reports Server (NTRS)

    Haarala, Arja-Riitta

    1994-01-01

    Finland poses some problems to be overcome in the field of scientific and technical information: a small user community which makes domestic systems costly; great distances within the country between users and suppliers of information; great distances to international data systems and large libraries abroad; and inadequate collections of scientific and technical information. The national bibliography Fennica includes all books and journals published in Finland. Data base services available in Finland include: reference data bases in science and technology; data banks for decision making such as statistical time series or legal proceedings; national bibliographies; and library catalogs.

  10. PIALA 2000: Libraries and Archives--Where Information and Language Literacy Begin [and] Engaged Readers and Writers in Multicultural Island Communities. Selected Papers from the 10th Pacific Islands Association of Libraries and Archives Conference Joint with the 13th Annual Regional Language Arts Conference (Tumon, Guam, November 9-11, 2000)

    ERIC Educational Resources Information Center

    Cohen, Arlene, Ed.; Quan, Clarisa G., Ed.

    2004-01-01

    This proceedings combines presentations from the jointly held 10th Annual PIALA 2000 Conference and the 13th Annual Regional Language Arts Conference. The volume begins with the welcoming remarks of Mary L. Silk, Christine Ku Scott-Smith, Antonio R. Umpingco, Delia Munoz Rosal, Lawrence Kasperbauer, Rosie Tainatongo, Richard S. Tom, Mary L.…

  11. Proceedings of the Annual Military Librarians’ Workshop (31st): Information Management and Intelligence Held in Washington, D.C. on 20-23 October 1987

    DTIC Science & Technology

    1987-10-23

    Engineering Laboratory Naval Postgraduate School Library, Code LO8A Dudley Knox Library Port Hueneme, CA 93043-5003 Monterey, CA 93943-5000 Cecilia J . Thorn...Pforzhetmer 23 "A Brief History of Military Deane J , Allen 38 Intelligence" "Popular Culture and the Cultural Dr. Hugo A. Keesing 73 Literacy Controversy...2200 Banjo Dancing * Arena Stage Old Vat Room ( J Buses will be provided at 1730 and 1930 from the hotel to Arena Stage and return to the hotel after the

  12. Proceedings of the (20th) Annual Military Librarians’ Workshop on Public Relations, United States Naval Academy, Annapolis, Maryland, 20-22 October 1976

    DTIC Science & Technology

    1976-10-22

    tat afec. out livs dont now wathyarvoig They’ doin’t i.now what they are doing simply becausc the have no adequa te basis to judge the effects of thir...publicity toGls. The main ones that I use are radio, te!hvision, newsletters for patrons, staff notes, booklets, posters , and last of all--the library...especially in the libraries. It is the most God awful color. You can cover t 13 it though. You can get loads of posters from all over the place--foreign

  13. A multicomponent CuAAC "click" approach to a library of hybrid polydentate 2-pyridyl-1,2,3-triazole ligands: new building blocks for the generation of metallosupramolecular architectures.

    PubMed

    Crowley, James D; Bandeen, Pauline H

    2010-01-14

    A one pot, multicomponent CuAAC reaction has been exploited for the safe generation of alkyl, benzyl or aryl linked polydentate pyridyl-1,2,3-triazole ligands from their corresponding halides, sodium azide and alkynes in excellent yields. The ligands have been fully characterised by elemental analysis, HR-ESMS, IR, (1)H and (13)C NMR and in two cases the structures were confirmed by X-ray crystallography. Additionally, we have examined the Ag(I) coordination chemistry of these ligands and found, using HR-ESMS, (1)H NMR, and X-ray crystallography, that both discrete and polymeric metallosupramolecular architectures can be formed.

  14. The function of male sperm whale slow clicks in a high latitude habitat: communication, echolocation, or prey debilitation?

    PubMed

    Oliveira, Cláudia; Wahlberg, Magnus; Johnson, Mark; Miller, Patrick J O; Madsen, Peter T

    2013-05-01

    Sperm whales produce different click types for echolocation and communication. Usual clicks and buzzes appear to be used primarily in foraging while codas are thought to function in social communication. The function of slow clicks is less clear, but they appear to be produced by males at higher latitudes, where they primarily forage solitarily, and on the breeding grounds, where they roam between groups of females. Here the behavioral context in which these vocalizations are produced and the function they may serve was investigated. Ninety-nine hours of acoustic and diving data were analyzed from sound recording tags on six male sperm whales in Northern Norway. The 755 slow clicks detected were produced by tagged animals at the surface (52%), ascending from a dive (37%), and during the bottom phase (11%), but never during the descent. Slow clicks were not associated with the production of buzzes, other echolocation clicks, or fast maneuvering that would indicate foraging. Some slow clicks were emitted in seemingly repetitive temporal patterns supporting the hypothesis that the function for slow clicks on the feeding grounds is long range communication between males, possibly relaying information about individual identity or behavioral states.

  15. Click chemistry for the conservation of cellular structures and fluorescent proteins: ClickOx.

    PubMed

    Löschberger, Anna; Niehörster, Thomas; Sauer, Markus

    2014-05-01

    Reactive oxygen species (ROS), including hydrogen peroxide, are known to cause structural damage not only in living, but also in fixed, cells. Copper-catalyzed azide-alkyne cycloaddition (click chemistry) is known to produce ROS. Therefore, fluorescence imaging of cellular structures, such as the actin cytoskeleton, remains challenging when combined with click chemistry protocols. In addition, the production of ROS substantially weakens the fluorescence signal of fluorescent proteins. This led us to develop ClickOx, which is a new click chemistry protocol for improved conservation of the actin structure and better conservation of the fluorescence signal of green fluorescent protein (GFP)-fusion proteins. Herein we demonstrate that efficient oxygen removal by addition of an enzymatic oxygen scavenger system (ClickOx) considerably reduces ROS-associated damage during labeling of nascent DNA with ATTO 488 azide by Cu(I)-catalyzed click chemistry. Standard confocal and super-resolution fluorescence images of phalloidin-labeled actin filaments and GFP/yellow fluorescent protein-labeled cells verify the conservation of the cytoskeleton microstructure and fluorescence intensity, respectively. Thus, ClickOx can be used advantageously for structure preservation in conventional and most notably in super-resolution microscopy methods. Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  16. Evaluation of tooth-click triggering and speech recognition in assistive technology for computer access.

    PubMed

    Simpson, Tyler; Gauthier, Michel; Prochazka, Arthur

    2010-02-01

    Computer access can play an important role in employment and leisure activities following spinal cord injury. The authors' prior work has shown that a tooth-click detecting device, when paired with an optical head mouse, may be used by people with tetraplegia for controlling cursor movement and mouse button clicks. To compare the efficacy of tooth clicks to speech recognition and that of an optical head mouse to a gyrometer head mouse for cursor and mouse button control of a computer. Six able-bodied and 3 tetraplegic subjects used the devices listed above to produce cursor movements and mouse clicks in response to a series of prompts displayed on a computer. The time taken to move to and click on each target was recorded. The use of tooth clicks in combination with either an optical head mouse or a gyrometer head mouse can provide hands-free cursor movement and mouse button control at a speed of up to 22% of that of a standard mouse. Tooth clicks were significantly faster at generating mouse button clicks than speech recognition when paired with either type of head mouse device. Tooth-click detection performed better than speech recognition when paired with both the optical head mouse and the gyrometer head mouse. Such a system may improve computer access for people with tetraplegia.

  17. Introduction to Physics (Mechanics): A Semi-Self Paced Approach.

    ERIC Educational Resources Information Center

    Schlenker, Richard M.

    Presented is a guide for an introductory college level physics course in mechanics. The course is contract graded and allows students to proceed at their own pace; however, lectures, problem solving sessions, and laboratory sessions are included. Students on an independent basis review video tapes, film loops, library study, and conduct an…

  18. Delivering Electronic Information in a Knowledge-Based Democracy. Summary of Proceedings (Washington, DC, July 14, 1993).

    ERIC Educational Resources Information Center

    Library of Congress, Washington, DC.

    The Library of Congress hosted a 1-day conference, "Delivering Electronic Information in a Knowledge-Based Democracy" to explore the public policy framework essential to creating electronic information resources and making them broadly available. Participants from a variety of sectors contributed to wide-ranging discussions on issues…

  19. Annotated black walnut literature

    Treesearch

    J. W. Van Sambeek

    2006-01-01

    Many of our publications on the establishment, management, and utilization of black walnut, butternut, and associated high-value hardwoods are printed in conference proceedings or scientific journals that are not readily available at most public libraries or on the internet. As Chair of the Education Committee, I have tried to summarize for you the relevant findings of...

  20. Annotated black walnut literature

    Treesearch

    J. W. Van Sambeek

    2007-01-01

    Many of the publications on establishment, management, and utilization of black walnut and other high-value hardwoods are printed in conference proceedings or scientific journals that are not readily available at most public libraries or on the internet. As Chair of the Education Committee of the Walnut Council, I have tried to summarize the findings from the following...

  1. Connecting to the Internet: The Challenge for Canada's County and Regional Libraries.

    ERIC Educational Resources Information Center

    Curry, Ann; Curtis, Alison

    2000-01-01

    Describes survey results that indicate Internet access and connectivity is proceeding rapidly despite the geographical, technical, and financial difficulties faced by Canadian systems with large geographical areas and members from different municipal or county jurisdictions. Discusses funding and using the World Wide Web as a reference tool.…

  2. Information Broker/Free Lance Librarian--New Careers--New Library Services. Miscellaneous Studies No. 3

    ERIC Educational Resources Information Center

    Minor, Barbara B., Ed.

    Proceedings of a workshop on the information broker--a person or organization that provides information on demand for a fee, usually to make a profit--includes edited transcripts of the following presentations: "Introduction," Maxine Davis; "The Free-Lance Alternative: Turning Traditional Skills New Directions," Susan Klement;…

  3. [Physiology in the mirror of systematic catalogue of Russian Academy of Sciences Library].

    PubMed

    Orlov, I V; Lazurkina, V B

    2011-07-01

    Representation of general human and animal physiology publications in the systematic catalogue of the Library of the Russian Academy of Sciences is considered. The organization of the catalogue as applied to the problems of physiology, built on the basis of library-bibliographic classification used in the Russian universal scientific libraries is described. The card files of the systematic catalogue of the Library contain about 8 million cards. Topics that reflect the problems of general physiology contain 39 headings. For the full range of sciences including physiology the tables of general types of divisions were developed. They have been marked by indexes using lower-case letters of the Russian alphabet. For further detalizations of these indexes decimal symbols are used. The indexes are attached directly to the field of knowledge index. With the current relatively easy availability of network resources value and relevance of any catalogue are reduced. However it concerns much more journal articles, rather than reference books, proceedings of various conferences, bibliographies, personalities, and especially the monographs contained in the systematic catalogue. The card systematic catalogue of the Library remains an important source of information on general physiology issues, as well as its magistral narrower sections.

  4. Sound source localization identification accuracy: Envelope dependencies.

    PubMed

    Yost, William A

    2017-07-01

    Sound source localization accuracy as measured in an identification procedure in a front azimuth sound field was studied for click trains, modulated noises, and a modulated tonal carrier. Sound source localization accuracy was determined as a function of the number of clicks in a 64 Hz click train and click rate for a 500 ms duration click train. The clicks were either broadband or high-pass filtered. Sound source localization accuracy was also measured for a single broadband filtered click and compared to a similar broadband filtered, short-duration noise. Sound source localization accuracy was determined as a function of sinusoidal amplitude modulation and the "transposed" process of modulation of filtered noises and a 4 kHz tone. Different rates (16 to 512 Hz) of modulation (including unmodulated conditions) were used. Providing modulation for filtered click stimuli, filtered noises, and the 4 kHz tone had, at most, a very small effect on sound source localization accuracy. These data suggest that amplitude modulation, while providing information about interaural time differences in headphone studies, does not have much influence on sound source localization accuracy in a sound field.

  5. Cloning and characterization of luciferase from a Fijian luminous click beetle.

    PubMed

    Mitani, Yasuo; Futahashi, Ryo; Niwa, Kazuki; Ohba, Nobuyoshi; Ohmiya, Yoshihiro

    2013-01-01

    Luminous click beetle is distributed almost exclusively in Central and South America with a single genus in Melanesia. Among these click beetles, the description of Melanesian species has been fragmentary, and its luciferase gene and phylogenetic relation to other click beetles still remain uncertain. We collected a living luminous click beetle, Photophorus jansonii in Fiji. It emits green-yellow light from two spots on the pronotum and has no ventral luminous organ. Here, we cloned a luciferase gene from this insect by RT-PCR. The deduced amino acid sequence showed high identity of ~85% to the luciferases derived from other click beetle species. The luciferase of the Fijian click beetle was produced as a recombinant protein to characterize its biochemical properties. The Km for D-luciferin and ATP were 173 and 270 μm, respectively. The luciferase was pH-insensitive and the spectrum measured at pH 8.0 showed a peak at 559 nm, which was in the range of green-yellow light as seen in the luminous spot of the living Fijian click beetle. The Fijian click beetle luciferase was assigned to the Elateridae clade by a phylogenetic analysis, but it made a clearly different branch from Pyrophorus group examined in this study. © 2013 The American Society of Photobiology.

  6. 'Click chemistry' for diagnosis: a patent review on exploitation of its emerging trends.

    PubMed

    Mandhare, Anita; Banerjee, Paromita; Bhutkar, Smita; Hirwani, Rajkumar

    2014-12-01

    Click chemistry is the novel synthetic approach towards developing reactions with large thermodynamic driving forces to give almost complete conversion of new molecular reagents to a single product. Thus, click chemistry describes the chemistry for making carbon-heteroatom-carbon bonds in benign solvents, especially in water, and having a plethora of chemical and biological applications. This has played an important role in early detection of diseases, real-time monitoring of drug delivery and investigating the biomolecular functions in vivo. This review aims at highlighting the research advancements in click chemistry published in the patent literature and categorizing the patents according to the technological progress. An extensive search was carried out to collect and analyze the patent information claiming the use of click chemistry in biotechnology, especially for diagnosis. The study further concentrates on licensing of the click chemistry patents and defining the recent breakthroughs. Different databases like Espacenet, ISI Web of Science, Patbase and Thomson Innovation are used to compile the relevant literature. In recent years, considerable development in the click concept has encouraged researchers in using click reactions in almost every branch of industry that uses chemistry. Click chemistry for chemical ligation has been immensely explored in the field of biotechnology especially for detection, diagnosis and therapeutics.

  7. Comparison of echolocation clicks from geographically sympatric killer whales and long-finned pilot whales (L).

    PubMed

    Eskesen, Ida G; Wahlberg, Magnus; Simon, Malene; Larsen, Ole Næsbye

    2011-07-01

    The source characteristics of biosonar signals from sympatric killer whales and long-finned pilot whales in a Norwegian fjord were compared. A total of 137 pilot whale and more than 2000 killer whale echolocation clicks were recorded using a linear four-hydrophone array. Of these, 20 pilot whale clicks and 28 killer whale clicks were categorized as being recorded on-axis. The clicks of pilot whales had a mean apparent source level of 196 dB re 1 μPa pp and those of killer whales 203 dB re 1 μPa pp. The duration of pilot whale clicks was significantly shorter (23 μs, S.E.=1.3) and the centroid frequency significantly higher (55 kHz, S.E.=2.1) than killer whale clicks (duration: 41 μs, S.E.=2.6; centroid frequency: 32 kHz, S.E.=1.5). The rate of increase in the accumulated energy as a function of time also differed between clicks from the two species. The differences in duration, frequency, and energy distribution may have a potential to allow for the distinction between pilot and killer whale clicks when using automated detection routines for acoustic monitoring. © 2011 Acoustical Society of America

  8. PANEL LIBRARY AND EDITOR

    NASA Technical Reports Server (NTRS)

    Raible, E.

    1994-01-01

    The Panel Library and Editor is a graphical user interface (GUI) builder for the Silicon Graphics IRIS workstation family. The toolkit creates "widgets" which can be manipulated by the user. Its appearance is similar to that of the X-Windows System. The Panel Library is written in C and is used by programmers writing user-friendly mouse-driven applications for the IRIS. GUIs built using the Panel Library consist of "actuators" and "panels." Actuators are buttons, dials, sliders, or other mouse-driven symbols. Panels are groups of actuators that occupy separate windows on the IRIS workstation. The application user can alter variables in the graphics program, or fire off functions with a click on a button. The evolution of data values can be tracked with meters and strip charts, and dialog boxes with text processing can be built. Panels can be stored as icons when not in use. The Panel Editor is a program used to interactively create and test panel library interfaces in a simple and efficient way. The Panel Editor itself uses a panel library interface, so all actions are mouse driven. Extensive context-sensitive on-line help is provided. Programmers can graphically create and test the user interface without writing a single line of code. Once an interface is judged satisfactory, the Panel Editor will dump it out as a file of C code that can be used in an application. The Panel Library (v9.8) and Editor (v1.1) are written in C-Language (63%) and Scheme, a dialect of LISP, (37%) for Silicon Graphics 4D series workstations running IRIX 3.2 or higher. Approximately 10Mb of disk space is required once compiled. 1.5Mb of main memory is required to execute the panel editor. This program is available on a .25 inch streaming magnetic tape cartridge in UNIX tar format for an IRIS, and includes a copy of XScheme, the public-domain Scheme interpreter used by the Panel Editor. The Panel Library Programmer's Manual is included on the distribution media. The Panel Library and Editor were released to COSMIC in 1991. Silicon Graphics, IRIS, and IRIX are trademarks of Silicon Graphics, Inc. X-Window System is a trademark of Massachusetts Institute of Technology.

  9. Leveraging Social Media to Promote Evidence-Based Continuing Medical Education.

    PubMed

    Flynn, Simone; Hebert, Paul; Korenstein, Deborah; Ryan, Mark; Jordan, William B; Keyhani, Salomeh

    2017-01-01

    New dissemination methods are needed to engage physicians in evidence-based continuing medical education (CME). To examine the effectiveness of social media in engaging physicians in non-industry-sponsored CME. We tested the effect of different media platforms (e-mail, Facebook, paid Facebook and Twitter), CME topics, and different "hooks" (e.g., Q&A, clinical pearl and best evidence) on driving clicks to a landing site featuring non-industry sponsored CME. We modelled the effects of social media platform, CME topic, and hook using negative binomial regression on clicks to a single landing site. We used clicks to landing site adjusted for exposure and message number to calculate rate ratios. To understand how physicians interact with CME content on social media, we also conducted interviews with 10 physicians. The National Physicians Alliance (NPA) membership. NPA e-mail recipients, Facebook followers and friends, and Twitter followers. Clicks to the NPA's CME landing site. On average, 4,544 recipients received each message. Messages generated a total of 592 clicks to the landing site, for a rate of 5.4 clicks per 1000 recipients exposed. There were 5.4 clicks from e-mail, 11.9 clicks from Facebook, 5.5 clicks from paid Facebook, and 6.9 clicks from Twitter to the landing site for 1000 physicians exposed to each of 4 selected CME modules. A Facebook post generated 2.3x as many clicks to the landing site as did an e-mail after controlling for participant exposure, hook type and CME topic (p<0.001). Twitter posts (p = 0.13) and paid Facebook posts (p = 0.06) were not statistically different from e-mail in generating clicks to the landing site. Use of different hooks to engage physicians had no impact on clicks to the landing site. Interviews with physicians suggested that social media might not be a preferred vehicle for disseminating CME. Social media has a modest impact on driving traffic to evidence-based CME options. Facebook had a superior effect on driving physician web traffic to evidence-based CME compared to other social media platforms and email.

  10. Leveraging Social Media to Promote Evidence-Based Continuing Medical Education

    PubMed Central

    Flynn, Simone; Hebert, Paul; Korenstein, Deborah; Ryan, Mark; Jordan, William B.

    2017-01-01

    Importance New dissemination methods are needed to engage physicians in evidence-based continuing medical education (CME). Objective To examine the effectiveness of social media in engaging physicians in non-industry-sponsored CME. Design We tested the effect of different media platforms (e-mail, Facebook, paid Facebook and Twitter), CME topics, and different “hooks” (e.g., Q&A, clinical pearl and best evidence) on driving clicks to a landing site featuring non-industry sponsored CME. We modelled the effects of social media platform, CME topic, and hook using negative binomial regression on clicks to a single landing site. We used clicks to landing site adjusted for exposure and message number to calculate rate ratios. To understand how physicians interact with CME content on social media, we also conducted interviews with 10 physicians. Setting The National Physicians Alliance (NPA) membership. Participants NPA e-mail recipients, Facebook followers and friends, and Twitter followers. Main Outcomes and Measures Clicks to the NPA’s CME landing site. Results On average, 4,544 recipients received each message. Messages generated a total of 592 clicks to the landing site, for a rate of 5.4 clicks per 1000 recipients exposed. There were 5.4 clicks from e-mail, 11.9 clicks from Facebook, 5.5 clicks from paid Facebook, and 6.9 clicks from Twitter to the landing site for 1000 physicians exposed to each of 4 selected CME modules. A Facebook post generated 2.3x as many clicks to the landing site as did an e-mail after controlling for participant exposure, hook type and CME topic (p<0.001). Twitter posts (p = 0.13) and paid Facebook posts (p = 0.06) were not statistically different from e-mail in generating clicks to the landing site. Use of different hooks to engage physicians had no impact on clicks to the landing site. Interviews with physicians suggested that social media might not be a preferred vehicle for disseminating CME. Conclusions Social media has a modest impact on driving traffic to evidence-based CME options. Facebook had a superior effect on driving physician web traffic to evidence-based CME compared to other social media platforms and email. PMID:28060854

  11. The combined effects of forward masking by noise and high click rate on monaural and binaural human auditory nerve and brainstem potentials.

    PubMed

    Pratt, Hillel; Polyakov, Andrey; Bleich, Naomi; Mittelman, Naomi

    2004-07-01

    To study effects of forward masking and rapid stimulation on human monaurally- and binaurally-evoked brainstem potentials and suggest their relation to synaptic fatigue and recovery and to neuronal action potential refractoriness. Auditory brainstem evoked potentials (ABEPs) were recorded from 12 normally- and symmetrically hearing adults, in response to each click (50 dB nHL, condensation and rarefaction) in a train of nine, with an inter-click interval of 11 ms, that followed a white noise burst of 100 ms duration (50 dB nHL). Sequences of white noise and click train were repeated at a rate of 2.89 s(-1). The interval between noise and first click in the train was 2, 11, 22, 44, 66 or 88 ms in different runs. ABEPs were averaged (8000 repetitions) using a dwell time of 25 micros/address/channel. The binaural interaction components (BICs) of ABEPs were derived and the single, centrally located equivalent dipoles of ABEP waves I and V and of the BIC major wave were estimated. The latencies of dipoles I and V of ABEP, their inter-dipole interval and the dipole magnitude of component V were significantly affected by the interval between noise and clicks and by the serial position of the click in the train. The latency and dipole magnitude of the major BIC component were significantly affected by the interval between noise and clicks. Interval from noise and the click's serial position in the train interacted to affect dipole V latency, dipole V magnitude, BIC latencies and the V-I inter-dipole latency difference. Most of the effects were fully apparent by the first few clicks in the train, and the trend (increase or decrease) was affected by the interval between noise and clicks. The changes in latency and magnitude of ABEP and BIC components with advancing position in the click train and the interactions of click position in the train with the intervals from noise indicate an interaction of fatigue and recovery, compatible with synaptic depletion and replenishing, respectively. With the 2 ms interval between noise and the first click in the train, neuronal action potential refractoriness may also be involved.

  12. Learning Clicks: Year End Report 2008/2009

    ERIC Educational Resources Information Center

    Alberta Advanced Education and Technology, 2009

    2009-01-01

    Learning Clicks was developed in 2003 as an interactive, fun way for Alberta students to learn about these opportunities. Learning Clicks is a program designed to support Strategy 2.4 in Alberta Advanced Education and Technology's 2007-10 Business Plan. The 2008/2009 season was the 5th year of the Learning Clicks program. This paper offers a…

  13. Separation of Sperm Whale Click-Trains for Multipath Rejection and Localization

    DTIC Science & Technology

    2010-03-05

    Correlation 12 3.3 Multipath Elimination Rules 13 4 LOCALIZATION 15 4.1 Localization Approach 15 4.2 Inter-Sensor Time-Delay Estimation Approach...Using Bayes’ rule , kj = ’°g kj = >°g< P(H, P(H0 HJ) \\J) (2) />(//,)p(zJ//,) p(H0)p(z,JH0) where p(//o) and p(H\\) are the a priori probabilities...overlapping clicks.) 3.3 MULTIPATH ELIMINATION RULES Multipath click-trains are eliminated if the individual clicks within the click-train are

  14. ENCOMPASS: A SAGA based environment for the compositon of programs and specifications, appendix A

    NASA Technical Reports Server (NTRS)

    Terwilliger, Robert B.; Campbell, Roy H.

    1985-01-01

    ENCOMPASS is an example integrated software engineering environment being constructed by the SAGA project. ENCOMPASS supports the specification, design, construction and maintenance of efficient, validated, and verified programs in a modular programming language. The life cycle paradigm, schema of software configurations, and hierarchical library structure used by ENCOMPASS is presented. In ENCOMPASS, the software life cycle is viewed as a sequence of developments, each of which reuses components from the previous ones. Each development proceeds through the phases planning, requirements definition, validation, design, implementation, and system integration. The components in a software system are modeled as entities which have relationships between them. An entity may have different versions and different views of the same project are allowed. The simple entities supported by ENCOMPASS may be combined into modules which may be collected into projects. ENCOMPASS supports multiple programmers and projects using a hierarchical library system containing a workspace for each programmer; a project library for each project, and a global library common to all projects.

  15. A comparison of muscular activity during single and double mouse clicks.

    PubMed

    Thorn, Stefan; Forsman, Mikael; Hallbeck, Susan

    2005-05-01

    Work-related musculoskeletal disorders (WMSDs) in the neck/shoulder region and the upper extremities are a common problem among computer workers. Occurrences of motor unit (MU) double discharges with very short inter-firing intervals (doublets) have been hypothesised as a potential additional risk for overuse of already exhausted fibres during long-term stereotyped activity. Doublets are reported to be present during double-click mouse work tasks. A few comparative studies have been carried out on overall muscle activities for short-term tasks with single types of actions, but none on occurrences of doublets during double versus single clicks. The main purpose of this study was to compare muscle activity levels of single and double mouse clicks during a long-term combined mouse/keyboard work task. Four muscles were studied: left and right upper trapezius, right extensor digitorum communis (EDC) and right flexor carpi ulnaris. Additionally, MU activity was analysed through intramuscular electromyography in the EDC muscle for a selection of subjects. The results indicate that double clicking produces neither higher median or 90th percentile levels in the trapezius and EDC muscles, nor a higher disposition for MU doublets, than does single clicking. Especially for the 90th percentile levels, the indications are rather the opposite (in the EDC significantly higher during single clicks in 8 of 11 subjects, P < 0.05). Although it cannot be concluded from the present study that double clicks are harmless, there were no signs that double clicks during computer work generally constitute a larger risk factor for WMSDs than do single clicks.

  16. Modification of chemical and conformational properties of natural organic matter by click chemistry as revealed by ESI-Orbitrap mass spectrometry.

    PubMed

    Nebbioso, Antonio; Piccolo, Alessandro

    2015-11-01

    A click reaction is reported here for the first time as a useful technique to control the conformational stability of natural organic matter (NOM) suprastructures. Click conjugates were successfully formed between a previously butynylated NOM hydrophobic fraction and a hydrophilic polyethylene glycol (PEG)-amino chain. The click products were shown by size exclusion chromatography (HPSEC) hyphenated with Orbitrap mass spectrometry (MS) in electrospray ionization (ESI) (+), while precursors were visible in ESI (-). Despite their increase in molecular weight, HPSEC elution of click conjugates occurred after that of precursors, thus showing their departure from the NOM supramolecular association. This indicates that the click-conjugated NOM molecules were varied in their hydrophilic and cationic character and lost the capacity to accommodate in the original hydrophobic suprastructures. The most abundant product had the C16H30O5N4 formula, a click conjugate of butanoic acid, while other products were short-chained (C4-C8) linear unsaturated and hydroxylated carboxylic acids. Tandem MS revealed formation of triazole rings in clicked conjugates and their two fragmentations at the ester and the C-N alkyl-aryl bonds. The behavior of NOM molecules modified by click chemistry confirms that hydrophobicity and ionic charge of humic molecules play a pivotal role in stabilizing intermolecular forces in NOM. Moreover, the versatility of the click reaction may become useful to decorate NOM molecules with a variety of substrates, in order to alter NOM conformational and chemical properties and diversify its applications in the environment.

  17. Genesis of the Mechanical Heart Valves' Ultrasonic Closing Clicks

    NASA Astrophysics Data System (ADS)

    Hasegawa, Jun; Kobayashi, Kenji

    A new in vitro experimental tool was developed to study the mechanism of the ultrasonic closing clicks' genesis of mechanical heart valves. Since the newly developed tester adopted compressed air flow directly instead of the blood analog fluid to drive the mechanical heart valve, it is not possibe to generate any cavitation. Closing clicks were measured with a small accelerometer at the surface of the valve holder made of silicone rubber. Ultrasonic closing clicks as well as audible closing clicks, similar to those measured clinically, could be observed using this setup. Thus, it was confirmed that the ultrasonic closing clicks can be generated without the existence of cavitation. Simultaneous measurements of the valve motion were made with a high-speed video camera, and the analysis of the video frames and clicks showed that higher frequency signal components of more than 50kHz could be generated only at the instant of the closure, which means the collision of the occluder with the housing. Eighteen miniature accelerometers with an area of one square millimeter were developed and stuck on the housing to monitor the distribution of the housing vibrations in detail, and it was found that the vibrations correspond to the ultrasonic closing clicks propagated from the valve stop: the collision point of the occluder with the housing. This fact indicated that the generation of ultrasonic closing clicks are limited to the small area of the collision. From those results, it was concluded that the major origin of the ultrasonic closing clicks' genesis should be the collision of the occluder with the housing.

  18. The Click and Twitch in Contemporary Poetry.

    ERIC Educational Resources Information Center

    Meredith, Bernard

    It is the creative writing instructor's role to help the student turn "twitch" poems into "click" poems ("twitch" being a kind of verbal hypertension that takes shape in the absence of anything humanly important to say on the poet's part and "click" being the finished poem that makes a sound like the click of the lid on a perfectly made box).…

  19. Dolphin "packet" use during long-range echolocation tasks.

    PubMed

    Finneran, James J

    2013-03-01

    When echolocating, dolphins typically emit a single broadband "click," then wait to receive the echo before emitting another click. However, previous studies have shown that during long-range echolocation tasks, they may instead emit a burst, or "packet," of several clicks, then wait for the packet of echoes to return before emitting another packet of clicks. The reasons for the use of packets are unknown. In this study, packet use was examined by having trained bottlenose dolphins perform long-range echolocation tasks. The tasks featured "phantom" echoes produced by capturing the dolphin's outgoing echolocation clicks, convolving the clicks with an impulse response to create an echo waveform, and then broadcasting the delayed, scaled echo to the dolphin. Dolphins were trained to report the presence of phantom echoes or a change in phantom echoes. Target range varied from 25 to 800 m. At ranges below 75 m, the dolphins rarely used packets. As the range increased beyond 75 m, two of the three dolphins increasingly produced packets, while the third dolphin instead utilized very high click repetition rates. The use of click packets appeared to be governed more by echo delay (target range) than echo amplitude.

  20. Comparisons of transient evoked otoacoustic emissions using chirp and click stimuli

    PubMed Central

    Keefe, Douglas H.; Feeney, M. Patrick; Hunter, Lisa L.; Fitzpatrick, Denis F.

    2016-01-01

    Transient-evoked otoacoustic emission (TEOAE) responses (0.7–8 kHz) were measured in normal-hearing adult ears using click stimuli and chirps whose local frequency increased or decreased linearly with time over the stimulus duration. Chirp stimuli were created by allpass filtering a click with relatively constant incident pressure level over frequency. Chirp TEOAEs were analyzed as a nonlinear residual signal by inverse allpass filtering each chirp response into an equivalent click response. Multi-window spectral and temporal averaging reduced noise levels compared to a single-window average. Mean TEOAE levels using click and chirp stimuli were similar with respect to their standard errors in adult ears. TEOAE group delay, group spread, instantaneous frequency, and instantaneous bandwidth were similar overall for chirp and click conditions, except for small differences showing nonlinear interactions differing across stimulus conditions. These results support the theory of a similar generation mechanism on the basilar membrane for both click and chirp conditions based on coherent reflection within the tonotopic region. TEOAE temporal fine structure was invariant across changes in stimulus level, which is analogous to the intensity invariance of click-evoked basilar-membrane displacement data. PMID:27914441

  1. Target distance-dependent variation of hearing sensitivity during echolocation in a false killer whale.

    PubMed

    Supin, Alexander Ya; Nachtigall, Paul E; Breese, Marlee

    2010-06-01

    Evidence of varying hearing sensitivity according to the target distance was obtained in a false killer whale Pseudorca crassidens during echolocation. Auditory evoked potentials (AEPs) triggered by echolocation clicks were recorded. The target distance varied from 1 to 6 m. The records contained AEPs to the self-heard emitted click and AEPs to the echoes. Mean level of echolocation clicks depended on distance (the longer the distance, the higher the click level), however, the effect of click level on AEP amplitude was eliminated by extracting AEPs to clicks of certain particular levels. The amplitude of the echo-provoked AEP was almost independent of distance, however, the amplitude of the AEP to the emitted click, did depend on distance within a range from 1 to 4 m: the longer the distance, the higher the amplitude. The latter result is interpreted as confirmational evidence that the animal is capable of varying hearing sensitivity according to target distance. The variation of hearing sensitivity may help to compensate for the echo attenuation with distance; as a secondary effect, this variation manifested itself in a variation of the amplitude of the AEP to emitted clicks.

  2. Non-auditory, electrophysiological potentials preceding dolphin biosonar click production.

    PubMed

    Finneran, James J; Mulsow, Jason; Jones, Ryan; Houser, Dorian S; Accomando, Alyssa W; Ridgway, Sam H

    2018-03-01

    The auditory brainstem response to a dolphin's own emitted biosonar click can be measured by averaging epochs of the instantaneous electroencephalogram (EEG) that are time-locked to the emitted click. In this study, averaged EEGs were measured using surface electrodes placed on the head in six different configurations while dolphins performed an echolocation task. Simultaneously, biosonar click emissions were measured using contact hydrophones on the melon and a hydrophone in the farfield. The averaged EEGs revealed an electrophysiological potential (the pre-auditory wave, PAW) that preceded the production of each biosonar click. The largest PAW amplitudes occurred with the non-inverting electrode just right of the midline-the apparent side of biosonar click generation-and posterior of the blowhole. Although the source of the PAW is unknown, the temporal and spatial properties rule out an auditory source. The PAW may be a neural or myogenic potential associated with click production; however, it is not known if muscles within the dolphin nasal system can be actuated at the high rates reported for dolphin click production, or if sufficiently coordinated and fast motor endplates of nasal muscles exist to produce a PAW detectable with surface electrodes.

  3. Recording and quantification of ultrasonic echolocation clicks from free-ranging toothed whales

    NASA Astrophysics Data System (ADS)

    Madsen, P. T.; Wahlberg, M.

    2007-08-01

    Toothed whales produce short, ultrasonic clicks of high directionality and source level to probe their environment acoustically. This process, termed echolocation, is to a large part governed by the properties of the emitted clicks. Therefore derivation of click source parameters from free-ranging animals is of increasing importance to understand both how toothed whales use echolocation in the wild and how they may be monitored acoustically. This paper addresses how source parameters can be derived from free-ranging toothed whales in the wild using calibrated multi-hydrophone arrays and digital recorders. We outline the properties required of hydrophones, amplifiers and analog to digital converters, and discuss the problems of recording echolocation clicks on the axis of a directional sound beam. For accurate localization the hydrophone array apertures must be adapted and scaled to the behavior of, and the range to, the clicking animal, and precise information on hydrophone locations is critical. We provide examples of localization routines and outline sources of error that lead to uncertainties in localizing clicking animals in time and space. Furthermore we explore approaches to time series analysis of discrete versions of toothed whale clicks that are meaningful in a biosonar context.

  4. Comparisons of transient evoked otoacoustic emissions using chirp and click stimuli.

    PubMed

    Keefe, Douglas H; Feeney, M Patrick; Hunter, Lisa L; Fitzpatrick, Denis F

    2016-09-01

    Transient-evoked otoacoustic emission (TEOAE) responses (0.7-8 kHz) were measured in normal-hearing adult ears using click stimuli and chirps whose local frequency increased or decreased linearly with time over the stimulus duration. Chirp stimuli were created by allpass filtering a click with relatively constant incident pressure level over frequency. Chirp TEOAEs were analyzed as a nonlinear residual signal by inverse allpass filtering each chirp response into an equivalent click response. Multi-window spectral and temporal averaging reduced noise levels compared to a single-window average. Mean TEOAE levels using click and chirp stimuli were similar with respect to their standard errors in adult ears. TEOAE group delay, group spread, instantaneous frequency, and instantaneous bandwidth were similar overall for chirp and click conditions, except for small differences showing nonlinear interactions differing across stimulus conditions. These results support the theory of a similar generation mechanism on the basilar membrane for both click and chirp conditions based on coherent reflection within the tonotopic region. TEOAE temporal fine structure was invariant across changes in stimulus level, which is analogous to the intensity invariance of click-evoked basilar-membrane displacement data.

  5. Spectrogram analysis of low to mid frequency marine mammal clicks

    NASA Astrophysics Data System (ADS)

    Ioup, George E.; Ioup, Juliette W.; Larue, James P.; Sidorovskaia, Natalia A.; Kuczaj, Stan A.; Rayborn, Grayson H.; Walker, Christopher D.

    2004-05-01

    Previous investigators have proposed explanations for some sperm whale click structure and pointed out that the separation of individual pulses within the click might be used to determine approximately the size of the sperm whales. Recently, Mohl et al. [J. Acoust. Soc. Am. 114, 1124-1154 (2003)] have shown that echo-location click structure is highly dependent on the received angle. In data measured by the Littoral Acoustic Demonstration Center using bottom-moored hydrophones in the northern Gulf of Mexico in the summers of 2001 and 2002, rich click structures were observed in the spectrograms of many click trains, some of which exhibit strikingly consistent spectral nulls across the train. Although this structure in the spectra could be due to propagation effects, investigations to date suggest this possibility is highly unlikely, as discussed in the next abstract. Therefore it is at least plausible that the structure could be used to identify individual animals. This is known to be a difficult problem in the case of sperm whales because of the angle dependence of at least some of their clicks. These difficulties are discussed, as is the possible use of the spectrograms of the clicks to identify individuals. [Research supported by ONR.

  6. Cu-free 1,3-dipolar cycloaddition click reactions to form isoxazole linkers in chelating ligands for fac-[M(I)(CO)3]+ centers (M = Re, 99mTc).

    PubMed

    Bottorff, Shalina C; Kasten, Benjamin B; Stojakovic, Jelena; Moore, Adam L; MacGillivray, Leonard R; Benny, Paul D

    2014-02-17

    Isoxazole ring formation was examined as a potential Cu-free alternative click reaction to Cu(I)-catalyzed alkyne/azide cycloaddition. The isoxazole reaction was explored at macroscopic and radiotracer concentrations with the fac-[M(I)(CO)3](+) (M = Re, (99m)Tc) core for use as a noncoordinating linker strategy between covalently linked molecules. Two click assembly methods (click, then chelate and chelate, then click) were examined to determine the feasibility of isoxazole ring formation with either alkyne-functionalized tridentate chelates or their respective fac-[M(I)(CO)3](+) complexes with a model nitrile oxide generator. Macroscale experiments, alkyne-functionalized chelates, or Re complexes indicate facile formation of the isoxazole ring. (99m)Tc experiments demonstrate efficient radiolabeling with click, then chelate; however, the chelate, then click approach led to faster product formation, but lower yields compared to the Re analogues.

  7. Interpretation in Historical Writing: The Study of Development in Librarianship.

    ERIC Educational Resources Information Center

    Colson, John Calvin

    Study of the development of libraries and librarianship may be done only historically, by analysis of the records of development. Such study necessarily is interpretive because historical study does not establish facts, but proceeds from them. In historical study an hypothesis may not be used as in scientific study, because the hypothesis is not…

  8. 78 FR 62009 - Eastern Shore Natural Gas Company; Notice of Availability of the Environmental Assessment for the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-11

    ... Garrison Energy Center, a 309-megawatt combined cycle natural gas fueled power plant under development in... measures, would not constitute a major federal action significantly affecting the quality of the human... and groups; newspapers and libraries in the project area; and parties to this proceeding. In addition...

  9. EDUCATION FOR HEALTH SCIENCES LIBRARIANSHIP, PROCEEDINGS OF AN INVITATIONAL CONFERENCE (SEATTLE, SEPTEMBER 10-12, 1967).

    ERIC Educational Resources Information Center

    LIEBERMAN, IRVING

    MEDICAL LIBRARIANS, HEALTH SCIENCE FACULTY, AND SPECIALISTS IN RELATED AREAS WERE PARTICIPANTS IN A CONFERENCE HELD TO EXAMINE THE NEEDS AND REQUIREMENTS FOR HEALTH SCIENCE LIBRARIANSHIP AND DEVELOP SUGGESTIONS FOR APPROPRIATE LIBRARY SCHOOL PROGRAMS. THIS REPORT CONTAINS THE COMPLETE TEXTS OF WORKING PAPERS PREPARED FOR THE CONFERENCE AND MAJOR…

  10. 75 FR 3732 - Notice of Suspension and Initiation of Debarment Proceedings; Schools and Libraries Universal...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-22

    ... defrauding the E-Rate Program.\\6\\ You admitted that you and others devised a scheme to defraud school... Technologies, Inc.\\7\\ In furtherance of the scheme, you submitted fraudulent and false documents to the... providers in violation of E-Rate Program rules.\\8\\ Ultimately, your scheme induced at least ten schools, in...

  11. 75 FR 20846 - Notice of Suspension and Initiation of Debarment Proceedings; Schools and Libraries Universal...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-21

    ... admitted that you and others devised schemes to defraud school districts and the E-Rate program by having..., your conspirators, and your company, primarily DeltaNet, Inc.\\6\\ In furtherance of the schemes, you...\\ Ultimately, your conspiracy was comprised of two closely related schemes that affected at least thirteen...

  12. 75 FR 20844 - Notice of Suspension and Initiation of Debarment Proceedings; Schools and Libraries Universal...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-21

    ... schemes to defraud school districts and the E-Rate program by having your co-conspirators steer E-rate..., primarily DeltaNet, Inc.\\6\\ In furtherance of the schemes, you submitted misleading, fraudulent and false... comprised of two closely related schemes that affected at least thirteen different schools in eight...

  13. Early Restoration Projects Atlas | NOAA Gulf Spill Restoration

    Science.gov Websites

    trustees are implementing. To view details of an individual project, click the View icon on the list below or click the project marker on the map. For definitions of the project detail click here. To highlight the location of a project from the list, click the Show on Map icon. This atlas will be updated as

  14. EAGLEView: A surface and grid generation program and its data management

    NASA Technical Reports Server (NTRS)

    Remotigue, M. G.; Hart, E. T.; Stokes, M. L.

    1992-01-01

    An old and proven grid generation code, the EAGLE grid generation package, is given an added dimension of a graphical interface and a real time data base manager. The Numerical Aerodynamic Simulation (NAS) Panel Library is used for the graphical user interface. Through the panels, EAGLEView constructs the EAGLE script command and sends it to EAGLE to be processed. After the object is created, the script is saved in a mini-buffer which can be edited and/or saved and reinterpreted. The graphical objects are set-up in a linked-list and can be selected or queried by pointing and clicking the mouse. The added graphical enhancement to the EAGLE system emphasizes the unique capability to construct field points around complex geometry and visualize the construction every step of the way.

  15. What speeds up the internal clock? Effects of clicks and flicker on duration judgements and reaction time.

    PubMed

    Wearden, J H; Williams, Emily A; Jones, Luke A

    2017-03-01

    Four experiments investigated the effect of pre-stimulus events on judgements of the subjective duration of tones that they preceded. Experiments 1 to 4 used click trains, flickering squares, expanding circles, and white noise as pre-stimulus events and showed that (a) periodic clicks appeared to "speed up" the pacemaker of an internal clock but that the effect wore off over a click-free delay, (b) aperiodic click trains, and visual stimuli in the form of flickering squares and expanding circles, also produced similar increases in estimated tone duration, as did white noise, although its effect was weaker. A fifth experiment examined the effects of periodic flicker on reaction time and showed that, as with periodic clicks in a previous experiment, reaction times were shorter when preceded by flicker than without.

  16. Learning of Multimodal Representations With Random Walks on the Click Graph.

    PubMed

    Wu, Fei; Lu, Xinyan; Song, Jun; Yan, Shuicheng; Zhang, Zhongfei Mark; Rui, Yong; Zhuang, Yueting

    2016-02-01

    In multimedia information retrieval, most classic approaches tend to represent different modalities of media in the same feature space. With the click data collected from the users' searching behavior, existing approaches take either one-to-one paired data (text-image pairs) or ranking examples (text-query-image and/or image-query-text ranking lists) as training examples, which do not make full use of the click data, particularly the implicit connections among the data objects. In this paper, we treat the click data as a large click graph, in which vertices are images/text queries and edges indicate the clicks between an image and a query. We consider learning a multimodal representation from the perspective of encoding the explicit/implicit relevance relationship between the vertices in the click graph. By minimizing both the truncated random walk loss as well as the distance between the learned representation of vertices and their corresponding deep neural network output, the proposed model which is named multimodal random walk neural network (MRW-NN) can be applied to not only learn robust representation of the existing multimodal data in the click graph, but also deal with the unseen queries and images to support cross-modal retrieval. We evaluate the latent representation learned by MRW-NN on a public large-scale click log data set Clickture and further show that MRW-NN achieves much better cross-modal retrieval performance on the unseen queries/images than the other state-of-the-art methods.

  17. Click-based echolocation in bats: not so primitive after all.

    PubMed

    Yovel, Yossi; Geva-Sagiv, Maya; Ulanovsky, Nachum

    2011-05-01

    Echolocating bats of the genus Rousettus produce click sonar signals, using their tongue (lingual echolocation). These signals are often considered rudimentary and are believed to enable only crude performance. However, the main argument supporting this belief, namely the click's reported long duration, was recently shown to be an artifact. In fact, the sonar clicks of Rousettus bats are extremely short, ~50-100 μs, similar to dolphin vocalizations. Here, we present a comparison between the sonar systems of the 'model species' of laryngeal echolocation, the big brown bat (Eptesicus fuscus), and that of lingual echolocation, the Egyptian fruit bat (Rousettus aegyptiacus). We show experimentally that in tasks, such as accurate landing or detection of medium-sized objects, click-based echolocation enables performance similar to laryngeal echolocators. Further, we describe a sophisticated behavioral strategy for biosonar beam steering in clicking bats. Finally, theoretical analyses of the signal design--focusing on their autocorrelations and wideband ambiguity functions--predict that in some aspects, such as target ranging and Doppler-tolerance, click-based echolocation might outperform laryngeal echolocation. Therefore, we suggest that click-based echolocation in bats should be regarded as a viable echolocation strategy, which is in fact similar to the biosonar used by most echolocating animals, including whales and dolphins.

  18. Assessing segmentation processes by click detection: online measure of statistical learning, or simple interference?

    PubMed

    Franco, Ana; Gaillard, Vinciane; Cleeremans, Axel; Destrebecqz, Arnaud

    2015-12-01

    Statistical learning can be used to extract the words from continuous speech. Gómez, Bion, and Mehler (Language and Cognitive Processes, 26, 212-223, 2011) proposed an online measure of statistical learning: They superimposed auditory clicks on a continuous artificial speech stream made up of a random succession of trisyllabic nonwords. Participants were instructed to detect these clicks, which could be located either within or between words. The results showed that, over the length of exposure, reaction times (RTs) increased more for within-word than for between-word clicks. This result has been accounted for by means of statistical learning of the between-word boundaries. However, even though statistical learning occurs without an intention to learn, it nevertheless requires attentional resources. Therefore, this process could be affected by a concurrent task such as click detection. In the present study, we evaluated the extent to which the click detection task indeed reflects successful statistical learning. Our results suggest that the emergence of RT differences between within- and between-word click detection is neither systematic nor related to the successful segmentation of the artificial language. Therefore, instead of being an online measure of learning, the click detection task seems to interfere with the extraction of statistical regularities.

  19. The energy ratio mapping algorithm: a tool to improve the energy-based detection of odontocete echolocation clicks.

    PubMed

    Klinck, Holger; Mellinger, David K

    2011-04-01

    The energy ratio mapping algorithm (ERMA) was developed to improve the performance of energy-based detection of odontocete echolocation clicks, especially for application in environments with limited computational power and energy such as acoustic gliders. ERMA systematically evaluates many frequency bands for energy ratio-based detection of echolocation clicks produced by a target species in the presence of the species mix in a given geographic area. To evaluate the performance of ERMA, a Teager-Kaiser energy operator was applied to the series of energy ratios as derived by ERMA. A noise-adaptive threshold was then applied to the Teager-Kaiser function to identify clicks in data sets. The method was tested for detecting clicks of Blainville's beaked whales while rejecting echolocation clicks of Risso's dolphins and pilot whales. Results showed that the ERMA-based detector correctly identified 81.6% of the beaked whale clicks in an extended evaluation data set. Average false-positive detection rate was 6.3% (3.4% for Risso's dolphins and 2.9% for pilot whales).

  20. “Click, Click, Cyclize”: A DOS Approach to Sultams Utilizing Vinyl Sulfonamide Linchpins

    PubMed Central

    Zhou, Aihua; Rayabarapu, Dinesh; Hanson, Paul R.

    2009-01-01

    A diversity-oriented synthesis (DOS) strategy termed “Click, Click, Cyclize” is reported. This approach relies on functional group (FG) pairing between a vinyl sulfonamide and an array of functional groups to synthesize skeletally diverse sultams. Several FG pairing pathways on central tertiary vinyl sulfonamide linchpins have been developed including intramolecular Heck, aza-Michael, ring-closing enyne metathesis, Pauson—Khand, and chemoselective oxidation/Baylis—Hillman reactions. PMID:19115841

  1. Click trains and the rate of information processing: does "speeding up" subjective time make other psychological processes run faster?

    PubMed

    Jones, Luke A; Allely, Clare S; Wearden, John H

    2011-02-01

    A series of experiments demonstrated that a 5-s train of clicks that have been shown in previous studies to increase the subjective duration of tones they precede (in a manner consistent with "speeding up" timing processes) could also have an effect on information-processing rate. Experiments used studies of simple and choice reaction time (Experiment 1), or mental arithmetic (Experiment 2). In general, preceding trials by clicks made response times significantly shorter than those for trials without clicks, but white noise had no effects on response times. Experiments 3 and 4 investigated the effects of clicks on performance on memory tasks, using variants of two classic experiments of cognitive psychology: Sperling's (1960) iconic memory task and Loftus, Johnson, and Shimamura's (1985) iconic masking task. In both experiments participants were able to recall or recognize significantly more information from stimuli preceded by clicks than those preceded by silence.

  2. 77 FR 31011 - Notice of Suspension and Commencement of Proposed Debarment Proceedings; Schools and Libraries...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-24

    ... with the E-Rate program while you were owner and president of E-Rate Consulting Services, LLC (ECS) in Montgomery, Alabama.\\7\\ ECS assisted schools and school districts in their efforts to qualify for E-Rate funding.\\8\\ ECS arranged to receive through the mail its clients' E-Rate checks, and was supposed to...

  3. Electronic Access to Information: A New Service Paradigm. Proceedings from a Symposium (July 23-24, 1993, Palo Alto, California).

    ERIC Educational Resources Information Center

    Chiang, Win-Shin S., Ed.; Elkington, Nancy E., Ed.

    The Research Libraries Group (RLG) hosted a symposium to explore opportunities for cooperative action--to take advantage of technology and to improve electronic access to information--particularly in the RLG context, and to develop strategies for making the most effective use of technology and electronic information in support of research and…

  4. Navy Libraries’ Information Storage and Retrieval System. Proceedings of the CONSATL Workshop and Meeting (38th), 23-25 April 1980,

    DTIC Science & Technology

    1981-04-01

    1606 David Taylor Naval Ship R&D Center (202)227- 1307 Mary Jane Brewster Naval Research Laboratory Donald R. Erickson AV 297-3425 Naval Sea Systems...Marshal Hughes Nannette M. Pope Naval Surface Weapons Center Armed Forces Radiobiology Research AV 249-8994 Institute (703)663-8994 (301)295- 0428

  5. 77 FR 24202 - Notice of Suspension and Commencement of Proposed Debarment Proceedings; Schools and Libraries...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-23

    ... . The text may also be purchased from the Commission's duplicating inspection and copying during regular... applicants.\\10\\ You also conspired to bribe school officials in exchange for their ceding control of the... at 2, 4 (E.D. La. filed June 2, 2011) (Factual Basis). \\10\\ Id. \\11\\ Id. at 3. These bribes included...

  6. An Application Practice of the IFLA FRBR Model: A Metadata Case Study for the National Palace Museum in Taipei.

    ERIC Educational Resources Information Center

    Chen, Ya-ning; Lin, Simon C.; Chen, Shu-jiun

    2002-01-01

    Explains the Functional Requirements for Bibliographic Records (FRBR) model which was proposed by the International Federation of Library Associations and Institutions (IFLA) as a framework to proceed content-based analysis and developing metadata format. Presents a case study that examines the feasibility of the FRBR model at the National Palace…

  7. 78 FR 66909 - Sabine Pass Liquefaction, LLC; Sabine Pass LNG, L.P.; Notice of Application to Amend...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-07

    ..., or call (713) 375-5000, or by email [email protected] . Or contact Lisa M. Tonery, Partner, Fulbright & Jaworski LLP, 666 Fifth Avenue, New York, NY 10103, or call (212)318-3009, or by email lisa...) and place it into the Commission's public record (eLibrary) for this proceeding; or issue a Notice of...

  8. Educational Documentation: Present and Future. Proceedings of an International Meeting (Florence, Italy, May 31-June 4, 1982).

    ERIC Educational Resources Information Center

    Biblioteca di Documentazione Pedagogica, Florence (Italy).

    The Library of Educational Documentation in Florence, Italy began work in 1980 on the establishment of an educational documentation system for Italy. Recognition of its role in this regard was accorded by the Regional Institutes for Educational Research, Innovation and Teacher Training (IRRSAE) and by the European Centre for Education (CEDE) in…

  9. 78 FR 36767 - Combined Notice of Filings #1

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-19

    .... Description: Notice of Cancellation of SA No. 3272 in Dkt No. ER12- 1473-000--Queue W2-026 to be effective 5...-5041. Comments Due: 5 p.m. ET 6/28/13. The filings are accessible in the Commission's eLibrary system... in any of the above proceedings must file in accordance with Rules 211 and 214 of the Commission's...

  10. HODGEPODGE: A Workshop. Proceedings (San Francisco, CA, February 22, 23, and 26, 1979).

    ERIC Educational Resources Information Center

    Fowler, Thomas S., Ed.

    Described on the agenda as "An Omnium Gatherum for Reference Librarians," this workshop presented by the staff of the Bay Area Reference Center (BARC) cites resources and explains search strategies used by BARC to respond to the types of questions most frequently submitted to them. Methods and tools that may be used by smaller libraries to answer…

  11. African Y chromosome and mtDNA divergence provides insight into the history of click languages.

    PubMed

    Knight, Alec; Underhill, Peter A; Mortensen, Holly M; Zhivotovsky, Lev A; Lin, Alice A; Henn, Brenna M; Louis, Dorothy; Ruhlen, Merritt; Mountain, Joanna L

    2003-03-18

    About 30 languages of southern Africa, spoken by Khwe and San, are characterized by a repertoire of click consonants and phonetic accompaniments. The Jumid R:'hoansi (!Kung) San carry multiple deeply coalescing gene lineages. The deep genetic diversity of the San parallels the diversity among the languages they speak. Intriguingly, the language of the Hadzabe of eastern Africa, although not closely related to any other language, shares click consonants and accompaniments with languages of Khwe and San. We present original Y chromosome and mtDNA variation of Hadzabe and other ethnic groups of Tanzania and Y chromosome variation of San and peoples of the central African forests: Biaka, Mbuti, and Lisongo. In the context of comparable published data for other African populations, analyses of each of these independently inherited DNA segments indicate that click-speaking Hadzabe and Jumid R:'hoansi are separated by genetic distance as great or greater than that between any other pair of African populations. Phylogenetic tree topology indicates a basal separation of the ancient ancestors of these click-speaking peoples. That genetic divergence does not appear to be the result of recent gene flow from neighboring groups. The deep genetic divergence among click-speaking peoples of Africa and mounting linguistic evidence suggest that click consonants date to early in the history of modern humans. At least two explanations remain viable. Clicks may have persisted for tens of thousands of years, independently in multiple populations, as a neutral trait. Alternatively, clicks may have been retained, because they confer an advantage during hunting in certain environments.

  12. People's Ability to Detect Objects Using Click-Based Echolocation: A Direct Comparison between Mouth-Clicks and Clicks Made by a Loudspeaker.

    PubMed

    Thaler, Lore; Castillo-Serrano, Josefina

    2016-01-01

    Echolocation is the ability to use reflected sound to obtain information about the spatial environment. Echolocation is an active process that requires both the production of the emission as well as the sensory processing of the resultant sound. Appreciating the general usefulness of echo-acoustic cues for people, in particular those with vision impairments, various devices have been built that exploit the principle of echolocation to obtain and provide information about the environment. It is common to all these devices that they do not require the person to make a sound. Instead, the device produces the emission autonomously and feeds a resultant sound back to the user. Here we tested if echolocation performance in a simple object detection task was affected by the use of a head-mounted loudspeaker as compared to active clicking. We found that 27 sighted participants new to echolocation did generally better when they used a loudspeaker as compared to mouth-clicks, and that two blind participants with experience in echolocation did equally well with mouth clicks and the speaker. Importantly, performance of sighted participants' was not statistically different from performance of blind experts when they used the speaker. Based on acoustic click data collected from a subset of our participants, those participants whose mouth clicks were more similar to the speaker clicks, and thus had higher peak frequencies and sound intensity, did better. We conclude that our results are encouraging for the consideration and development of assistive devices that exploit the principle of echolocation.

  13. People’s Ability to Detect Objects Using Click-Based Echolocation: A Direct Comparison between Mouth-Clicks and Clicks Made by a Loudspeaker

    PubMed Central

    Thaler, Lore; Castillo-Serrano, Josefina

    2016-01-01

    Echolocation is the ability to use reflected sound to obtain information about the spatial environment. Echolocation is an active process that requires both the production of the emission as well as the sensory processing of the resultant sound. Appreciating the general usefulness of echo-acoustic cues for people, in particular those with vision impairments, various devices have been built that exploit the principle of echolocation to obtain and provide information about the environment. It is common to all these devices that they do not require the person to make a sound. Instead, the device produces the emission autonomously and feeds a resultant sound back to the user. Here we tested if echolocation performance in a simple object detection task was affected by the use of a head-mounted loudspeaker as compared to active clicking. We found that 27 sighted participants new to echolocation did generally better when they used a loudspeaker as compared to mouth-clicks, and that two blind participants with experience in echolocation did equally well with mouth clicks and the speaker. Importantly, performance of sighted participants’ was not statistically different from performance of blind experts when they used the speaker. Based on acoustic click data collected from a subset of our participants, those participants whose mouth clicks were more similar to the speaker clicks, and thus had higher peak frequencies and sound intensity, did better. We conclude that our results are encouraging for the consideration and development of assistive devices that exploit the principle of echolocation. PMID:27135407

  14. Design of the biosonar simulator for dolphin's clicks waveform reproduction

    NASA Astrophysics Data System (ADS)

    Ishii, Ken; Akamatsu, Tomonari; Hatakeyama, Yoshimi

    1992-03-01

    The emitted clicks of Dall's porpoises consist of a pulse train of burst signals with an ultrasonic carrier frequency. The authors have designed a biosonar simulator to reproduce the waveforms associated with a dolphin's clicks underwater. The total reproduction system consists of a click signal acquisition block, a waveform analysis block, a memory unit, a click simulator, and a underwater, ultrasonic wave transmitter. In operation, data stored in an EPROM (Erasable Programmable Read Only Memory) are read out sequentially by a fast clock and converted to analog output signals. Then an ultrasonic power amplifier reproduces these signals through a transmitter. The click signal replaying block is referred to as the BSS (Biosonar Simulator). This is what simulates the clicks. The details of the BSS are described in this report. A unit waveform is defined. The waveform is divided into a burst period and a waiting period. Clicks are a sequence based on a unit waveform, and digital data are sequentially read out from an EPROM of waveform data. The basic parameters of the BSS are as follows: (1) reading clock, 100 ns to 25.4 microseconds; (2) number of reading clock, 34 to 1024 times; (3) counter clock in a waiting period, 100 ns to 25.4 microseconds; (4) number of counter clock, zero to 16,777,215 times; (5) number of burst/waiting repetition cycle, one to 128 times; and (6) transmission level adjustment by a programmable attenuator, zero to 86.5 dB. These basic functions enable the BSS to replay clicks of Dall's porpoise precisely.

  15. Towards high conductivity in anion-exchange membranes for alkaline fuel cells.

    PubMed

    Li, Nanwen; Guiver, Michael D; Binder, Wolfgang H

    2013-08-01

    Quaternized poly(2,6-dimethylphenylene oxide) materials (PPOs) containing clicked 1,2,3-triazoles were first prepared through Cu(I) -catalyzed "click chemistry" to improve the anion transport in anion-exchange membranes (AEMs). Clicked 1,2,3-triazoles incorporated into AEMs provided more sites to form efficient and continuous hydrogen-bond networks between the water/hydroxide and the triazole for anion transport. Higher water uptake was observed for these triazole membranes. Thus, the membranes showed an impressive enhancement of the hydroxide diffusion coefficient and, therefore, the anion conductivities. The recorded hydroxide conductivity was 27.8-62 mS cm(-1) at 20 °C in water, which was several times higher than that of a typical PPO-based AEM (TMA-20) derived from trimethylamine (5 mS cm(-1) ). Even at reduced relative humidity, the clicked membrane showed superior conductivity to a trimethylamine-based membrane. Moreover, similar alkaline stabilities at 80 °C in 1 M NaOH were observed for the clicked and non-clicked membranes. The performance of a H2 /O2 single cell assembled with a clicked AEM was much improved compared to that of a non-clicked TMA-20 membrane. The peak power density achieved for an alkaline fuel cell with the synthesized membrane 1a(20) was 188.7 mW cm(-2) at 50 °C. These results indicated that clicked AEM could be a viable strategy for improving the performance of alkaline fuel cells. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  16. U.S. Army Concept of Operations and Standard Operating Procedure for Acquisition Program Managers Using Item Unique Identification

    DTIC Science & Technology

    2017-09-01

    Figure 58. Click on run ................................................................................................61 Figure 59. Top view of...engines, helicopter rotors, and turbine blades , and so forth Creating Marks Readable with a Scanner 4.  Simple techniques to follow:  Make the light...spreadsheet with data Figure 58. Click on Menu bar and find “View” then click on “Macros.” Click on run Figure 59. 62 Top view of xml spreadsheet

  17. Clicking in a Killer Whale Habitat: Narrow-Band, High-Frequency Biosonar Clicks of Harbour Porpoise (Phocoena phocoena) and Dall’s Porpoise (Phocoenoides dalli)

    PubMed Central

    Kyhn, Line A.; Tougaard, Jakob; Beedholm, Kristian; Jensen, Frants H.; Ashe, Erin; Williams, Rob; Madsen, Peter T.

    2013-01-01

    Odontocetes produce a range of different echolocation clicks but four groups in different families have converged on producing the same stereotyped narrow band high frequency (NBHF) click. In microchiropteran bats, sympatric species have evolved the use of different acoustic niches and subtly different echolocation signals to avoid competition among species. In this study, we examined whether similar adaptations are at play among sympatric porpoise species that use NBHF echolocation clicks. We used a six-element hydrophone array to record harbour and Dall’s porpoises in British Columbia (BC), Canada, and harbour porpoises in Denmark. The click source properties of all porpoise groups were remarkably similar and had an average directivity index of 25 dB. Yet there was a small, but consistent and significant 4 kHz difference in centroid frequency between sympatric Dall’s (137±3 kHz) and Canadian harbour porpoises (141±2 kHz). Danish harbour porpoise clicks (136±3 kHz) were more similar to Dall’s porpoise than to their conspecifics in Canada. We suggest that the spectral differences in echolocation clicks between the sympatric porpoises are consistent with evolution of a prezygotic isolating barrier (i.e., character displacement) to avoid hybridization of sympatric species. In practical terms, these spectral differences have immediate application to passive acoustic monitoring. PMID:23723996

  18. Clicking in a killer whale habitat: narrow-band, high-frequency biosonar clicks of harbour porpoise (Phocoena phocoena) and Dall's porpoise (Phocoenoides dalli).

    PubMed

    Kyhn, Line A; Tougaard, Jakob; Beedholm, Kristian; Jensen, Frants H; Ashe, Erin; Williams, Rob; Madsen, Peter T

    2013-01-01

    Odontocetes produce a range of different echolocation clicks but four groups in different families have converged on producing the same stereotyped narrow band high frequency (NBHF) click. In microchiropteran bats, sympatric species have evolved the use of different acoustic niches and subtly different echolocation signals to avoid competition among species. In this study, we examined whether similar adaptations are at play among sympatric porpoise species that use NBHF echolocation clicks. We used a six-element hydrophone array to record harbour and Dall's porpoises in British Columbia (BC), Canada, and harbour porpoises in Denmark. The click source properties of all porpoise groups were remarkably similar and had an average directivity index of 25 dB. Yet there was a small, but consistent and significant 4 kHz difference in centroid frequency between sympatric Dall's (137±3 kHz) and Canadian harbour porpoises (141±2 kHz). Danish harbour porpoise clicks (136±3 kHz) were more similar to Dall's porpoise than to their conspecifics in Canada. We suggest that the spectral differences in echolocation clicks between the sympatric porpoises are consistent with evolution of a prezygotic isolating barrier (i.e., character displacement) to avoid hybridization of sympatric species. In practical terms, these spectral differences have immediate application to passive acoustic monitoring.

  19. Click train encoding in primary and non-primary auditory cortex of anesthetized macaque monkeys.

    PubMed

    Oshurkova, E; Scheich, H; Brosch, M

    2008-06-02

    We studied encoding of temporally modulated sounds in 28 multiunits in the primary auditory cortical field (AI) and in 35 multiunits in the secondary auditory cortical field (caudomedial auditory cortical field, CM) by presenting periodic click trains with click rates between 1 and 300 Hz lasting for 2-4 s. We found that all multiunits increased or decreased their firing rate during the steady state portion of the click train and that all except two multiunits synchronized their firing to individual clicks in the train. Rate increases and synchronized responses were most prevalent and strongest at low click rates, as expressed by best modulation frequency, limiting frequency, percentage of responsive multiunits, and average rate response and vector strength. Synchronized responses occurred up to 100 Hz; rate response occurred up to 300 Hz. Both auditory fields responded similarly to low click rates but differed at click rates above approximately 12 Hz at which more multiunits in AI than in CM exhibited synchronized responses and increased rate responses and more multiunits in CM exhibited decreased rate responses. These findings suggest that the auditory cortex of macaque monkeys encodes temporally modulated sounds similar to the auditory cortex of other mammals. Together with other observations presented in this and other reports, our findings also suggest that AI and CM have largely overlapping sensitivities for acoustic stimulus features but encode these features differently.

  20. Click-Evoked Auditory Efferent Activity: Rate and Level Effects.

    PubMed

    Boothalingam, Sriram; Kurke, Julianne; Dhar, Sumitrajit

    2018-05-07

    There currently are no standardized protocols to evaluate auditory efferent function in humans. Typical tests use broadband noise to activate the efferents, but only test the contralateral efferent pathway, risk activating the middle ear muscle reflex (MEMR), and are laborious for clinical use. In an attempt to develop a clinical test of bilateral auditory efferent function, we have designed a method that uses clicks to evoke efferent activity, obtain click-evoked otoacoustic emissions (CEOAEs), and monitor MEMR. This allows for near-simultaneous estimation of cochlear and efferent function. In the present study, we manipulated click level (60, 70, and 80 dB peak-equivalent sound pressure level [peSPL]) and rate (40, 50, and 62.5 Hz) to identify an optimal rate-level combination that evokes measurable efferent modulation of CEOAEs. Our findings (n = 58) demonstrate that almost all click levels and rates used caused significant inhibition of CEOAEs, with a significant interaction between level and rate effects. Predictably, bilateral activation produced greater inhibition compared to stimulating the efferents only in the ipsilateral or contralateral ear. In examining the click rate-level effects during bilateral activation in greater detail, we observed a 1-dB inhibition of CEOAE level for each 10-dB increase in click level, with rate held constant at 62.5 Hz. Similarly, a 10-Hz increase in rate produced a 0.74-dB reduction in CEOAE level, with click level held constant at 80 dB peSPL. The effect size (Cohen's d) was small for either monaural condition and medium for bilateral, faster-rate, and higher-level conditions. We were also able to reliably extract CEOAEs from efferent eliciting clicks. We conclude that clicks can indeed be profitably employed to simultaneously evaluate cochlear health using CEOAEs as well as their efferent modulation. Furthermore, using bilateral clicks allows the evaluation of both the crossed and uncrossed elements of the auditory efferent nervous system, while yielding larger, more discernible, inhibition of the CEOAEs relative to either ipsilateral or contralateral condition.

  1. Protein modification via alkyne hydrosilylation using a substoichiometric amount of ruthenium(ii) catalyst† †Dedicated to Professor Stuart L. Schreiber on the occasion of his 60th birthday. ‡ ‡Electronic supplementary information (ESI) available. See DOI: 10.1039/c6sc05313k Click here for additional data file.

    PubMed Central

    Kwan, Terence T.-L.; Boutureira, Omar; Frye, Elizabeth C.; Walsh, Stephen J.; Gupta, Moni K.; Wallace, Stephen; Wu, Yuteng; Zhang, Fengzhi; Sore, Hannah F.; Galloway, Warren R. J. D.; Chin, Jason W.; Welch, Martin; Bernardes, Gonçalo J. L.

    2017-01-01

    Transition metal catalysis has emerged as a powerful strategy to expand synthetic flexibility of protein modification. Herein, we report a cationic Ru(ii) system that enables the first example of alkyne hydrosilylation between dimethylarylsilanes and O-propargyl-functionalized proteins using a substoichiometric amount or low-loading of Ru(ii) catalyst to achieve the first C–Si bond formation on full-length substrates. The reaction proceeds under physiological conditions at a rate comparable to other widely used bioorthogonal reactions. Moreover, the resultant gem-disubstituted vinylsilane linkage can be further elaborated through thiol–ene coupling or fluoride-induced protodesilylation, demonstrating its utility in further rounds of targeted modifications. PMID:28966779

  2. Nonecholocating fruit bats produce biosonar clicks with their wings.

    PubMed

    Boonman, Arjan; Bumrungsri, Sara; Yovel, Yossi

    2014-12-15

    Because evolution mostly acts over millions of years, the intermediate steps leading to a functional sensory system remain enigmatic. Accordingly, there is an ongoing debate regarding the evolution of bat echolocation. In search of the origin of bat echolocation, we studied how Old World fruit bats, which have always been classified as nonecholocating, orient in complete darkness. We found that two of these nonecholocating species used click-like sounds to detect and discriminate objects in complete darkness. However, we discovered that this click-based echo sensing is rudimentary and does not allow these bats to estimate distance accurately as all other echolocating bats can. Moreover, unlike all other echolocating bats, which generate pulses using the larynx or the tongue, these bats generated clicks with their wings. We provide evidence suggesting that all Old World fruit bats can click with their wings. Although this click-based echo sensing used by Old World fruit bats may not represent the ancestral form of current (laryngeal) bat echolocation, we argue that clicking fruit bats could be considered behavioral fossils, opening a window to study the evolution of echolocation. Copyright © 2014 Elsevier Ltd. All rights reserved.

  3. Vocal reporting of echolocation targets: dolphins often report before click trains end.

    PubMed

    Ridgway, S H; Elsberry, W R; Blackwood, D J; Kamolnick, T; Todd, M; Carder, D A; Chaplin, Monica; Cranford, T W

    2012-01-01

    Bottlenose dolphins (Tursiops truncatus) wore opaque suction cups over their eyes while stationing behind an acoustically opaque door. This put the dolphins in a known position and orientation. When the door opened, the dolphin clicked to detect targets. Trainers specified that Dolphin S emit a whistle if the target was a 7.5 cm water filled sphere, or a pulse burst if the target was a rock. S remained quiet if there was no target. Dolphin B whistled for the sphere. She remained quiet for rock and for no target. Thus, S had to choose between three different responses, whistle, pulse burst, or remain quiet. B had to choose between two different responses, whistle or remain quiet. S gave correct vocal responses averaging 114 ms after her last echolocation click (range 182 ms before and 219 ms after the last click). Average response for B was 21 ms before her last echolocation click (range 250 ms before and 95 ms after the last click in the train). More often than not, B began her whistle response before her echolocation train ended. The findings suggest separate neural pathways for generation of response vocalizations as opposed to echolocation clicks. © 2012 Acoustical Society of America.

  4. Learning to rank using user clicks and visual features for image retrieval.

    PubMed

    Yu, Jun; Tao, Dacheng; Wang, Meng; Rui, Yong

    2015-04-01

    The inconsistency between textual features and visual contents can cause poor image search results. To solve this problem, click features, which are more reliable than textual information in justifying the relevance between a query and clicked images, are adopted in image ranking model. However, the existing ranking model cannot integrate visual features, which are efficient in refining the click-based search results. In this paper, we propose a novel ranking model based on the learning to rank framework. Visual features and click features are simultaneously utilized to obtain the ranking model. Specifically, the proposed approach is based on large margin structured output learning and the visual consistency is integrated with the click features through a hypergraph regularizer term. In accordance with the fast alternating linearization method, we design a novel algorithm to optimize the objective function. This algorithm alternately minimizes two different approximations of the original objective function by keeping one function unchanged and linearizing the other. We conduct experiments on a large-scale dataset collected from the Microsoft Bing image search engine, and the results demonstrate that the proposed learning to rank models based on visual features and user clicks outperforms state-of-the-art algorithms.

  5. Automating spectral measurements

    NASA Astrophysics Data System (ADS)

    Goldstein, Fred T.

    2008-09-01

    This paper discusses the architecture of software utilized in spectroscopic measurements. As optical coatings become more sophisticated, there is mounting need to automate data acquisition (DAQ) from spectrophotometers. Such need is exacerbated when 100% inspection is required, ancillary devices are utilized, cost reduction is crucial, or security is vital. While instrument manufacturers normally provide point-and-click DAQ software, an application programming interface (API) may be missing. In such cases automation is impossible or expensive. An API is typically provided in libraries (*.dll, *.ocx) which may be embedded in user-developed applications. Users can thereby implement DAQ automation in several Windows languages. Another possibility, developed by FTG as an alternative to instrument manufacturers' software, is the ActiveX application (*.exe). ActiveX, a component of many Windows applications, provides means for programming and interoperability. This architecture permits a point-and-click program to act as automation client and server. Excel, for example, can control and be controlled by DAQ applications. Most importantly, ActiveX permits ancillary devices such as barcode readers and XY-stages to be easily and economically integrated into scanning procedures. Since an ActiveX application has its own user-interface, it can be independently tested. The ActiveX application then runs (visibly or invisibly) under DAQ software control. Automation capabilities are accessed via a built-in spectro-BASIC language with industry-standard (VBA-compatible) syntax. Supplementing ActiveX, spectro-BASIC also includes auxiliary serial port commands for interfacing programmable logic controllers (PLC). A typical application is automatic filter handling.

  6. Using a journal availability study to improve access.

    PubMed

    Shaw-Kokot, J; de la Varre, C

    2001-01-01

    Identify journal collection access and use factors. University of North Carolina at Chapel Hill's Health Sciences Library patrons. Survey forms and user interactions were monitored once a week for twelve weeks during the fall 1997 semester. The project was based on a 1989 New Mexico State University study and used Kantor's Branching Analysis to measure responses. 80% of reported sought journal articles were found successfully. Along with journal usage data, the library obtained demographic and behavioral information. Journals are the library's most used resource and, even as more electronic journals are offered, print journals continue to make up the majority of the collection. Several factors highlighted the need to study journal availability. User groups indicated that finding journals was problematic, and internal statistics showed people requesting interlibrary loans for owned items. The study looked at success rates, time, and ease of finding journals. A variety of reasons contributed to not finding journals. While overall user reports indicated relatively high success rate and satisfaction, there were problems to be addressed. As the library proceeds in redesigning both the physical space and electronic presence, the collected data have provided valuable direction.

  7. Source parameter estimates of echolocation clicks from wild pygmy killer whales (Feresa attenuata) (L)

    NASA Astrophysics Data System (ADS)

    Madsen, P. T.; Kerr, I.; Payne, R.

    2004-10-01

    Pods of the little known pygmy killer whale (Feresa attenuata) in the northern Indian Ocean were recorded with a vertical hydrophone array connected to a digital recorder sampling at 320 kHz. Recorded clicks were directional, short (25 μs) transients with estimated source levels between 197 and 223 dB re. 1 μPa (pp). Spectra of clicks recorded close to or on the acoustic axis were bimodal with peak frequencies between 45 and 117 kHz, and with centroid frequencies between 70 and 85 kHz. The clicks share characteristics of echolocation clicks from similar sized, whistling delphinids, and have properties suited for the detection and classification of prey targeted by this odontocete. .

  8. Kansas Department of Health and Environment - Immunization Program

    Science.gov Websites

    Immunize and Win a Prize Click on Immunize Win a Prize logo for more information Yellow Fever Click on the logo above for more information on Yellow Fever PERINATAL HEPATITIS B PREVENTION PROGRAM Click on logo

  9. Ionic liquid syntheses via click chemistry: expeditious routes toward versatile functional materials.

    PubMed

    Mirjafari, Arsalan

    2018-03-25

    Since the introduction of click chemistry by K. B. Sharpless in 2001, its exploration and exploitation has occurred in countless fields of materials sciences in both academic and industrial spheres. Click chemistry is defined as an efficient, robust, and orthogonal synthetic platform for the facile formation of new carbon-heteroatom bonds, using readily available starting materials. Premier examples of click reactions are copper(i)-catalyzed azide-alkyne Huisgen cycloaddition (CuAAC) and the thiol-X (X = ene and yne) coupling reactions to form C-N and C-S bonds, respectively. The emphasis of this review is centered on the rapidly expanding area of click chemistry-mediated synthesis of functional ionic liquids via CuAAC, thiol-X and oxime formation, and selected examples of nucleophilic ring-opening reactions, while offering some thoughts on emerging challenges, opportunities and ultimately the evolution of this field. Click chemistry offers tremendous opportunities, and introduces intriguing perspectives for efficient and robust generation of tailored task-specific ionic liquids - an important class of soft materials.

  10. High throughput imaging cytometer with acoustic focussing† †Electronic supplementary information (ESI) available: High throughput imaging cytometer with acoustic focussing. See DOI: 10.1039/c5ra19497k Click here for additional data file. Click here for additional data file. Click here for additional data file. Click here for additional data file. Click here for additional data file. Click here for additional data file. Click here for additional data file. Click here for additional data file.

    PubMed Central

    Zmijan, Robert; Jonnalagadda, Umesh S.; Carugo, Dario; Kochi, Yu; Lemm, Elizabeth; Packham, Graham; Hill, Martyn

    2015-01-01

    We demonstrate an imaging flow cytometer that uses acoustic levitation to assemble cells and other particles into a sheet structure. This technique enables a high resolution, low noise CMOS camera to capture images of thousands of cells with each frame. While ultrasonic focussing has previously been demonstrated for 1D cytometry systems, extending the technology to a planar, much higher throughput format and integrating imaging is non-trivial, and represents a significant jump forward in capability, leading to diagnostic possibilities not achievable with current systems. A galvo mirror is used to track the images of the moving cells permitting exposure times of 10 ms at frame rates of 50 fps with motion blur of only a few pixels. At 80 fps, we demonstrate a throughput of 208 000 beads per second. We investigate the factors affecting motion blur and throughput, and demonstrate the system with fluorescent beads, leukaemia cells and a chondrocyte cell line. Cells require more time to reach the acoustic focus than beads, resulting in lower throughputs; however a longer device would remove this constraint. PMID:29456838

  11. Digital Debates. WebWise Conference on Libraries and Museums in the Digital World Proceedings (10th, Capitol Hill, Washington, D.C, February 25-27, 2009)

    ERIC Educational Resources Information Center

    Zorich, Diane

    2010-01-01

    Debates typically invoke an image of individuals arguing over the merits of opposing viewpoints. However, the term has a softer, more deliberative sense that connotes reflection, discussion, and consideration. The 2009 WebWise conference, titled "Digital Debates," was conducted in this spirit, with panelists and attendees engaged in…

  12. 38 CFR 14.637 - Payment of the expenses of agents and attorneys in proceedings before Agencies of Original...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...; Rules of Practice and Information Concerning Fees, 38 U.s.c. 5901-5905 § 14.637 Payment of the expenses... particular claim, the cost of copies of medical records or other documents obtained from an outside source... obtaining or operating office equipment or a legal library, salaries of the representative and his or her...

  13. 77 FR 48154 - Notice of Suspension and Commencement of Proposed Debarment Proceedings; Schools and Libraries...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-13

    ... letter to ``your conviction'' refers to the jury's verdict finding you guilty on one count of theft of..., Jury Trial, No. 11 CR 548 GBD (S.D.N.Y. 2012) (Trial Tr.); United States v. Willard Lanham, No. 11 CR..., 2012, a jury rendered a guilty verdict convicting you on one count of theft of federal funds and three...

  14. Failure Rates for Fiber Optic Assemblies

    DTIC Science & Technology

    1980-10-01

    Information Service (NTIS). At NTIS it will be releasable to the general public, including foreign nations. RADC-TR-80-322 has been reviewed and is...Literature sources searched (in addition to the RAC automated library information retrieval system) include the National Technical Information Service (NTIS...Proceedings 1976, 26th Electronic Components Conference. Price, S.J., et al. FOR RELIABLE SERVICE ENVIRONMENT PERFORMANCE, ENCAPSULATED LEDS WITH CLEAR

  15. Development of an Information Sheet for Intermediary Users of the Defense Technical Information Center’s Defense RDT&E Online System.

    DTIC Science & Technology

    1985-09-01

    Spiegel, "How to Reach Your Online Market ," National Online Meeting, New York, April 30-May 2, 1985, Proceedings - -985, (Medford, N.J.: Learned...Libraries 71 (November 1980): 469-474. Spiegel, Robert. "How to Reach Your Online Market ." National Online Meeting, New York, April 30-May 2, 1985

  16. Alternative Careers in Information/Library Services: Summary of Proceedings of a Workshop. Miscellaneous Studies No. 5.

    ERIC Educational Resources Information Center

    Minor, Barbara B., Ed.

    This report of a two-day workshop on non-traditional careers in librarianship provides the text of five major presentations as well as summaries of the three alternative sessions which followed. Each of the speakers described a different type of career: (1) Alice S. Warner of Warner-Eddison Associates is an information broker; (2) Robert E. Herz…

  17. Information Literacy: The Australian Agenda. Proceedings of a Conference Conducted by the University of South Australia Library (Adelaide, South Australia, Australia, December 2-4, 1992).

    ERIC Educational Resources Information Center

    Booker, Di, Ed.

    The aims of this conference were to promote information literacy as a means of personal and national advancement in today's information-dependent society; to emphasize information literacy as an essential competency for lifelong learning; to ensure that all delegates understand information literacy and its importance for the economic and social…

  18. Click it or ticket evaluation, 2008–2009 : traffic tech.

    DOT National Transportation Integrated Search

    2013-06-01

    Click It or Ticket (CIOT) is a high-visibility enforcement : program to increase seat belt use. Click It or Ticket was : adopted as a national program in 2003 and is credited : with steady increases in seat belt use across the Nation. : In 2009, seat...

  19. Preserve America Summit

    Science.gov Websites

    the recommendations, see the Executive Summary or the Full Report) More than a year has passed, and reports on each recommendation. Comprehensive Inventory (click to read report) Agencies involved: NPS , ACHP (with NCSHPO) Cultural Diversity (click to read report) Agencies involved: NPS Disasters (click to

  20. Electronic device increases threshold sensitivity and removes noise from FM communications receiver

    NASA Technical Reports Server (NTRS)

    Conrad, W. M.; Loch, F. J.

    1971-01-01

    Threshold extension device connected between demodulator output and filter output minimizes clicking noise. Device consists of click-eliminating signal transfer channel with follow-and-hold circuit and detector for sensing click impulses. Final output consists of signal plus low level noise without high amplitude impulses.

  1. Echolocation behaviour adapted to prey in foraging Blainville's beaked whale (Mesoplodon densirostris)

    PubMed Central

    Johnson, M; Hickmott, L.S; Aguilar Soto, N; Madsen, P.T

    2007-01-01

    Toothed whales echolocating in the wild generate clicks with low repetition rates to locate prey but then produce rapid sequences of clicks, called buzzes, when attempting to capture prey. However, little is known about the factors that determine clicking rates or how prey type and behaviour influence echolocation-based foraging. Here we study Blainville's beaked whales foraging in deep water using a multi-sensor DTAG that records both outgoing echolocation clicks and echoes returning from mesopelagic prey. We demonstrate that the clicking rate at the beginning of buzzes is related to the distance between whale and prey, supporting the presumption that whales focus on a specific prey target during the buzz. One whale showed a bimodal relationship between target range and clicking rate producing abnormally slow buzz clicks while attempting to capture large echoic targets, probably schooling prey, with echo duration indicating a school diameter of up to 4.3 m. These targets were only found when the whale performed tight circling manoeuvres spending up to five times longer in water volumes with large targets than with small targets. The result indicates that toothed whales in the wild can adjust their echolocation behaviour and movement for capture of different prey on the basis of structural echo information. PMID:17986434

  2. Timing and context of dolphin clicks during and after mine simulator detection and marking in the open ocean

    PubMed Central

    Dibble, Dianna S.; Kennemer, Jaime A.

    2018-01-01

    ABSTRACT Two dolphins carrying cameras swam in the ocean as they searched for and marked mine simulators – buried, proud or moored. As the animals swam ahead of a boat they searched the ocean. Cameras on their harness recorded continuous sound and video. Once a target was detected, the dolphins received a marker to take to the simulator's location. During search and detection, dolphins made almost continuous trains of varying interval clicks. During the marking phase, shorter click trains were interrupted by periods of silence. As the dolphins marked simulators, they often produced victory squeals – pulse bursts that vary in duration, peak frequency and amplitude. Victory squeals were produced on 72% of marks. Sometimes after marking, or at other times during their long swims, the dolphins produced click packets. Packets typically consisted of two to 10 clicks with inter-click intervals of 7-117 ms followed by a silence of 223-983 ms. Click packets appeared unrelated with searching or marking. We suggest that the packets were used to improve signal to noise ratios for locating a boat or other distant object. Victory squeals produced when marking the targets suggest to us that the dolphins know when they have succeeded in this multipart task. PMID:29463515

  3. Timing and context of dolphin clicks during and after mine simulator detection and marking in the open ocean.

    PubMed

    Ridgway, Sam H; Dibble, Dianna S; Kennemer, Jaime A

    2018-02-20

    Two dolphins carrying cameras swam in the ocean as they searched for and marked mine simulators - buried, proud or moored. As the animals swam ahead of a boat they searched the ocean. Cameras on their harness recorded continuous sound and video. Once a target was detected, the dolphins received a marker to take to the simulator's location. During search and detection, dolphins made almost continuous trains of varying interval clicks. During the marking phase, shorter click trains were interrupted by periods of silence. As the dolphins marked simulators, they often produced victory squeals - pulse bursts that vary in duration, peak frequency and amplitude. Victory squeals were produced on 72% of marks. Sometimes after marking, or at other times during their long swims, the dolphins produced click packets. Packets typically consisted of two to 10 clicks with inter-click intervals of 7-117 ms followed by a silence of 223-983 ms. Click packets appeared unrelated with searching or marking. We suggest that the packets were used to improve signal to noise ratios for locating a boat or other distant object. Victory squeals produced when marking the targets suggest to us that the dolphins know when they have succeeded in this multipart task. © 2018. Published by The Company of Biologists Ltd.

  4. Dynamic allocation of attention to metrical and grouping accents in rhythmic sequences.

    PubMed

    Kung, Shu-Jen; Tzeng, Ovid J L; Hung, Daisy L; Wu, Denise H

    2011-04-01

    Most people find it easy to perform rhythmic movements in synchrony with music, which reflects their ability to perceive the temporal periodicity and to allocate attention in time accordingly. Musicians and non-musicians were tested in a click localization paradigm in order to investigate how grouping and metrical accents in metrical rhythms influence attention allocation, and to reveal the effect of musical expertise on such processing. We performed two experiments in which the participants were required to listen to isochronous metrical rhythms containing superimposed clicks and then to localize the click on graphical and ruler-like representations with and without grouping structure information, respectively. Both experiments revealed metrical and grouping influences on click localization. Musical expertise improved the precision of click localization, especially when the click coincided with a metrically strong beat. Critically, although all participants located the click accurately at the beginning of an intensity group, only musicians located it precisely when it coincided with a strong beat at the end of the group. Removal of the visual cue of grouping structures enhanced these effects in musicians and reduced them in non-musicians. These results indicate that musical expertise not only enhances attention to metrical accents but also heightens sensitivity to perceptual grouping.

  5. Interrelationships between intranarial pressure and biosonar clicks in the bottlenose dolphin (Tursiops truncatus)

    NASA Astrophysics Data System (ADS)

    Elsberry, Wesley R.; Cranford, Ted W.; Ridgway, Sam H.; Carder, Donald A.; Vanbonn, William G.; Blackwood, Diane J.; Carr, Jennifer A.; Evans, William E.

    2002-05-01

    Three Atlantic bottlenose dolphins (Tursiops truncatus) were given a target recognition biosonar task. During their performance of the task, both acoustic data in the far field and pressure within the bony nasal passages were digitally recorded (Elsberry et al., 1999). Analysis of over 15000 biosonar clicks provided new insights into odontocete biosonar sound production and is consistent with acoustic and pressure data taken from white whales (Delphinapterus leucas) during biosonar (Ridgway and Carder, 1988). Our work provides the first evidence for a minimum intranarial pressure during biosonar click production for any odontocete (11.8+/-0.5 kPascals over basal pressure). All three subjects exhibited nearly the same minimum tranarial pressure difference during biosonar click production. Clicks produced at or near this minimum intranarial pressure exhibited a wide range of acoustic power values. The acoustic power of a biosonar click was not highly correlated with intranarial pressure (R2=0.116). The radiated acoustic energy in biosonar clicks ranged from 1 to 1370 microJoules. Estimates of mechanical work during pressurization events were produced using a piston/cylinder model and intranarial volume data from prepared specimens and computed tomography scans. Mechanical work during pressurization events ranged from 2.74 to 23.0 Joules, with an average of 10.3 Joules.

  6. A method to incorporate interstitial components into the TPS gynecologic rigid applicator library.

    PubMed

    Otal, Antonio; Richart, Jose; Rodriguez, Silvia; Santos, Manuel; Perez-Calatayud, Jose

    2017-02-01

    T2 magnetic resonance imaging (MRI) is recommended as the imaging modality for image-guided brachytherapy. In locally advanced cervical carcinoma, combined endocavitary and interstitial applicators are appropriate (Vienna or Utrecht). To cover extensive disease, Template Benidorm (TB) was developed. Treatment planning system applicator libraries are currently unavailable for the Utrecht applicator or the TB. The purpose of this work is to develop an applicator library for both applicators. The library developed in this work has been used in the Oncentra Brachytherapy TPS, version 4.3.0, which has a brachytherapy module that includes a library of rigid applicators. To add the needles of the Utrecht applicator and to model the TB, we used FreeCAD and MeshLab. The reconstruction process was based on the points that the rigid section and the interstitial part have in common. This, together with the free length, allowed us to ascertain the position of the tip. In case of the Utrecht applicator, one of the sources of uncertainty in the reconstruction was determining the distance of the tip of needle from the ovoid. In case of the TB, the large number of needles involved made their identification time consuming. The developed library resolved both issues. The developed library for the Utrecht and TB is feasible and efficient improving accuracy. It allows all the required treatment planning to proceed using just a T2 MRI sequence. The additional use of specific free available software applications makes it possible to add this information to the already existing library of the Oncentra Brachytherapy TPS. Specific details not included on this manuscript will be available under request. This library is also currently being implemented also into the Sagiplan v 2.0 TPS.

  7. (18)F-glyco-RGD peptides for PET imaging of integrin expression: efficient radiosynthesis by click chemistry and modulation of biodistribution by glycosylation.

    PubMed

    Maschauer, Simone; Haubner, Roland; Kuwert, Torsten; Prante, Olaf

    2014-02-03

    Glycosylation frequently improves the biokinetics and clearance properties of macromolecules in vivo and could therefore be used for the design of radiopharmaceuticals for positron emission tomography (PET). Recently, we have developed a click chemistry method for (18)F-fluoroglycosylation of alkyne-bearing RGD-peptides targeting the integrin receptor. To investigate whether this strategy could yield an (18)F-labeled RGD glycopeptide with favorable biokinetics, we generated a series of new RGD glycopeptides, varying the 6-fluoroglycosyl residue from monosaccharide to disaccharide units, which provided the glucosyl ([(19)F]6Glc-RGD, 4b), galactosyl ([(19)F]Gal-RGD, 4c), maltosyl ([(19)F]Mlt-RGD, 4e), and cellobiosyl ([(19)F]Cel-RGD, 4f) conjugated peptides in high yields and purities of >97%. All of these RGD glycopeptides showed high affinity to αvβ3 (11-55 nM), αvβ5 (6-14 nM), and to αvβ3-positive U87MG cells (90-395 nM). (18)F-labeling of the various carbohydrate precursors (1a-f) using cryptate-assisted reaction conditions (CH3CN, 85 °C, 10 min) gave (18)F-labeled glycosyl azides in radiochemical yields (RCYs) of up to 84% ([(18)F]2b). The deacetylation and subsequent click reaction with the alkyne-bearing cyclic RGD peptide proceeded in one-pot reactions with RCYs as high as 81% in 15-20 min at 60 °C, using a minimal amount of peptide precursor (100 nmol). Optimization of the radiosynthesis strategy gave a decay-uncorrected RCY of 16-24% after 70-75 min (based on [(18)F]fluoride). Due to their high-yield radiosyntheses, the glycopeptides [(18)F]6Glc-RGD and [(18)F]Mlt-RGD were chosen for comparative biodistribution studies and dynamic small-animal PET imaging using U87MG tumor-bearing nude mice. [(18)F]6Glc-RGD and [(18)F]Mlt-RGD showed significantly decreased liver and kidney uptake by PET relative to the 2-[(18)F]fluoroglucosyl analog [(18)F]2Glc-RGD, and showed specific tumor uptake in vivo. Notably, [(18)F]Mlt-RGD revealed uptake and retention in the U87MG tumor comparable to that of [(18)F]Galacto-RGD. Both [(18)F]6Glc-RGD and [(18)F]Mlt-RGD were obtained by a reliable and easy click chemistry-based procedure, much more rapidly than was [(18)F]Galacto-RGD. Due to its favorable biodistribution and tissue clearance in vivo, [(18)F]Mlt-RGD represents a viable alternative radiotracer for imaging integrin expression in solid tumors by PET.

  8. Male discrimination of receptive and unreceptive female calls by temporal features

    PubMed Central

    Elliott, Taffeta M.; Kelley, Darcy B.

    2012-01-01

    Summary In murky, crowded ponds in South Africa, female clawed frogs, Xenopus laevis (Daudin), vocalize to signal reproductive state. Female calls consist of acoustically similar clicks delivered in trains with characteristic rates. The rapping call of a sexually receptive female has a more rapid click rate [81 ms mean interclick interval (ICI)] than the ticking call of an unreceptive female (219 ms ICI). Rapping stimulates male advertisement calling, whereas ticking suppresses an already calling male. We examined how males label and discriminate female click rates. A labeling boundary experiment revealed that males perceive click rates between the means of rapping and ticking as lying on a continuum. They respond to 98 and 160 ms ICI as though to rapping and ticking, respectively. However, calling evoked by a click rate equally common to both calls (120 ms ICI) did not differ from the response to either rapping or ticking. A second experiment evaluated whether males discriminate click rates both labeled as ticking (180 and 219 ms ICI). Ticking suppresses advertising males, and suppressed males habituate (resume calling) to prolonged ticking. Both ticking stimuli suppressed males with equal effectiveness, and males habituated in equivalent amounts of time. When the stimulus was switched during habituation, no dishabituation occurred. We conclude that male labeling of click trains as rapping or ticking reflects an ambiguity resulting from the overlap in ICIs naturally occurring in the calls. Males do not respond differentially to click rates within the ticking category. Males thus combine discriminating and non-discriminating strategies in responding to the salient feature of female calls. PMID:17690231

  9. Click Chemistry and Radiochemistry: The First 10 Years.

    PubMed

    Meyer, Jan-Philip; Adumeau, Pierre; Lewis, Jason S; Zeglis, Brian M

    2016-12-21

    The advent of click chemistry has had a profound influence on almost all branches of chemical science. This is particularly true of radiochemistry and the synthesis of agents for positron emission tomography (PET), single photon emission computed tomography (SPECT), and targeted radiotherapy. The selectivity, ease, rapidity, and modularity of click ligations make them nearly ideally suited for the construction of radiotracers, a process that often involves working with biomolecules in aqueous conditions with inexorably decaying radioisotopes. In the following pages, our goal is to provide a broad overview of the first 10 years of research at the intersection of click chemistry and radiochemistry. The discussion will focus on four areas that we believe underscore the critical advantages provided by click chemistry: (i) the use of prosthetic groups for radiolabeling reactions, (ii) the creation of coordination scaffolds for radiometals, (iii) the site-specific radiolabeling of proteins and peptides, and (iv) the development of strategies for in vivo pretargeting. Particular emphasis will be placed on the four most prevalent click reactions-the Cu-catalyzed azide-alkyne cycloaddition (CuAAC), the strain-promoted azide-alkyne cycloaddition (SPAAC), the inverse electron demand Diels-Alder reaction (IEDDA), and the Staudinger ligation-although less well-known click ligations will be discussed as well. Ultimately, it is our hope that this review will not only serve to educate readers but will also act as a springboard, inspiring synthetic chemists and radiochemists alike to harness click chemistry in even more innovative and ambitious ways as we embark upon the second decade of this fruitful collaboration.

  10. 77 FR 75602 - Safety Zone, Atlantic Intracoastal Waterway; Oak Island, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-21

    ... DEPARTMENT OF HOMELAND SECURITY Coast Guard 33 CFR Part 165 [Docket Number USCG-2012-1062] RIN...-2012-1062) in the ``SEARCH'' box and click ``SEARCH.'' Click on ``Submit a Comment'' on the line...://www.regulations.gov , type the docket number (USCG-2012-1062) in the ``SEARCH'' box and click ``SEARCH...

  11. Iterated intracochlear reflection shapes the envelopes of basilar-membrane click responses

    PubMed Central

    Shera, Christopher A.

    2015-01-01

    Multiple internal reflection of cochlear traveling waves has been argued to provide a plausible explanation for the waxing and waning and other temporal structures often exhibited by the envelopes of basilar-membrane (BM) and auditory-nerve responses to acoustic clicks. However, a recent theoretical analysis of a BM click response measured in chinchilla concludes that the waveform cannot have arisen via any equal, repetitive process, such as iterated intracochlear reflection [Wit and Bell (2015), J. Acoust. Soc. Am. 138, 94–96]. Reanalysis of the waveform contradicts this conclusion. The measured BM click response is used to derive the frequency-domain transfer function characterizing every iteration of the loop. The selfsame transfer function that yields waxing and waning of the BM click response also captures the spectral features of ear-canal stimulus-frequency otoacoustic emissions measured in the same animal, consistent with the predictions of multiple internal reflection. Small shifts in transfer-function phase simulate results at different measurement locations and reproduce the heterogeneity of BM click response envelopes observed experimentally. PMID:26723327

  12. 'Megapclicks': acoustic click trains and buzzes produced during night-time foraging of humpback whales (Megaptera novaeangliae).

    PubMed

    Stimpert, Alison K; Wiley, David N; Au, Whitlow W L; Johnson, Mark P; Arsenault, Roland

    2007-10-22

    Humpback whales (Megaptera novaeangliae) exhibit a variety of foraging behaviours, but neither they nor any baleen whale are known to produce broadband clicks in association with feeding, as do many odontocetes. We recorded underwater behaviour of humpback whales in a northwest Atlantic feeding area using suction-cup attached, multi-sensor, acoustic tags (DTAGs). Here we describe the first recordings of click production associated with underwater lunges from baleen whales. Recordings of over 34000 'megapclicks' from two whales indicated relatively low received levels at the tag (between 143 and 154dB re 1 microPa pp), most energy below 2kHz, and interclick intervals often decreasing towards the end of click trains to form a buzz. All clicks were recorded during night-time hours. Sharp body rolls also occurred at the end of click bouts containing buzzes, suggesting feeding events. This acoustic behaviour seems to form part of a night-time feeding tactic for humpbacks and also expands the known acoustic repertoire of baleen whales in general.

  13. LINCS Canvas Browser: interactive web app to query, browse and interrogate LINCS L1000 gene expression signatures.

    PubMed

    Duan, Qiaonan; Flynn, Corey; Niepel, Mario; Hafner, Marc; Muhlich, Jeremy L; Fernandez, Nicolas F; Rouillard, Andrew D; Tan, Christopher M; Chen, Edward Y; Golub, Todd R; Sorger, Peter K; Subramanian, Aravind; Ma'ayan, Avi

    2014-07-01

    For the Library of Integrated Network-based Cellular Signatures (LINCS) project many gene expression signatures using the L1000 technology have been produced. The L1000 technology is a cost-effective method to profile gene expression in large scale. LINCS Canvas Browser (LCB) is an interactive HTML5 web-based software application that facilitates querying, browsing and interrogating many of the currently available LINCS L1000 data. LCB implements two compacted layered canvases, one to visualize clustered L1000 expression data, and the other to display enrichment analysis results using 30 different gene set libraries. Clicking on an experimental condition highlights gene-sets enriched for the differentially expressed genes from the selected experiment. A search interface allows users to input gene lists and query them against over 100 000 conditions to find the top matching experiments. The tool integrates many resources for an unprecedented potential for new discoveries in systems biology and systems pharmacology. The LCB application is available at http://www.maayanlab.net/LINCS/LCB. Customized versions will be made part of the http://lincscloud.org and http://lincs.hms.harvard.edu websites. © The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.

  14. Triazolophostins: a library of novel and potent agonists of IP3 receptors.

    PubMed

    Vibhute, Amol M; Konieczny, Vera; Taylor, Colin W; Sureshan, Kana M

    2015-06-28

    IP3 receptors are channels that mediate the release of Ca(2+) from the intracellular stores of cells stimulated by hormones or neurotransmitters. Adenophostin A (AdA) is the most potent agonist of IP3 receptors, with the β-anomeric adenine contributing to the increased potency. The potency of AdA and its stability towards the enzymes that degrade IP3 have aroused interest in AdA analogs for biological studies. The complex structure of AdA poses problems that have necessitated optimization of synthetic conditions for each analog. Such lengthy one-at-a-time syntheses limit access to AdA analogs. We have addressed this problem by synthesizing a library of triazole-based AdA analogs, triazolophostins, by employing click chemistry. An advanced intermediate having all the necessary phosphates and a β-azide at the anomeric position was reacted with various alkynes under Cu(i) catalysis to yield triazoles, which upon deprotection gave triazolophostins. All eleven triazolophostins synthesized are more potent than IP3 and some are equipotent with AdA in functional analyses of IP3 receptors. We show that a triazole ring can replace adenine without compromising the potency of AdA and provide facile routes to novel AdA analogs.

  15. Click-MS: Tagless Protein Enrichment Using Bioorthogonal Chemistry for Quantitative Proteomics.

    PubMed

    Smits, Arne H; Borrmann, Annika; Roosjen, Mark; van Hest, Jan C M; Vermeulen, Michiel

    2016-12-16

    Epitope-tagging is an effective tool to facilitate protein enrichment from crude cell extracts. Traditionally, N- or C-terminal fused tags are employed, which, however, can perturb protein function. Unnatural amino acids (UAAs) harboring small reactive handles can be site-specifically incorporated into proteins, thus serving as a potential alternative for conventional protein tags. Here, we introduce Click-MS, which combines the power of site-specific UAA incorporation, bioorthogonal chemistry, and quantitative mass spectrometry-based proteomics to specifically enrich a single protein of interest from crude mammalian cell extracts. By genetic encoding of p-azido-l-phenylalanine, the protein of interest can be selectively captured using copper-free click chemistry. We use Click-MS to enrich proteins that function in different cellular compartments, and we identify protein-protein interactions, showing the great potential of Click-MS for interaction proteomics workflows.

  16. Coming Full Circle. The Transborder Library Forum Proceedings = Completands el Circulo. [Memorias del] Foro Trinacional de Bibliotecas (6th, Tucson, Arizona, February 15-17, 1996).

    ERIC Educational Resources Information Center

    Arizona Library Association.

    At the sixth transborder forum, librarians from the United States, Canada, and Mexico gathered to explore topics of interest to academic, public, school, and special librarians in all three countries. The conference program and general information are provided in English and Spanish. Presentations, some in English and some in Spanish, include:…

  17. Palladium-catalyzed substitution of (coumarinyl)methyl acetates with C-, N-, and S-nucleophiles

    PubMed Central

    Chattopadhyay, Kalicharan; Fenster, Erik; Grenning, Alexander J

    2012-01-01

    Summary The palladium-catalyzed nucleophilic substitution of (coumarinyl)methyl acetates is described. The reaction proceeds though a palladium π-benzyl-like complex and allows for many different types of C-, N-, and S-nucleophiles to be regioselectively added to the biologically active coumarin motif. This new method was utilized to prepare a 128-membered library of aminated coumarins for biological screening. PMID:23019448

  18. Reading for All; Proceedings of the IRA (International Reading Association) World Congress on Reading (4th, Buenos Aires, Argentina, August 3-5, 1972).

    ERIC Educational Resources Information Center

    Karlin, Robert, Ed.

    This book contains papers presented at the Fourth International Reading Association World Congress on Reading in Buenos Aires, Argentina, in August 1972. The contents of the book are divided into three parts: "Literacy and Literature" includes papers on libraries, books, and reading by Jorge Borges, the future of reading by Theodore Harris, the…

  19. Proceedings of Colloquium 110 of the International Astronomical Union on Library and Information Services in Astronomy Held in Washington, DC on 26 July- 1 August 1988

    DTIC Science & Technology

    1989-01-01

    executive overview, IBM System Service, Stuttgart. 2. Doyen, P., 1987. Analyse d’opportunite et aspects fonctionnels d’une gestion integree par un systeme...Inst. di Astron. Tucson, AZ 85726-6732 Campus do Vale Citta. Universitaria 90049 Porto Alegre RS Viale A. Doris Mo. Vagiawari Alladi BRAZIL 1-95125

  20. Energy harvesting from mouse click of robot finger using piezoelectrics

    NASA Astrophysics Data System (ADS)

    Cha, Youngsu; Hong, Jin; Lee, Jaemin; Park, Jung-Min; Kim, Keehoon

    2017-04-01

    In this paper, we investigate the feasibility of energy harvesting from the mouse click motion using a piezoelectric energy transducer. Specifically, we use a robotic finger to realize repeatable mouse click motion. The robotic finger wears a glove with a pocket for including the piezoelectric material as an energy transducer. We propose a model for the energy harvesting system through the inverse kinematic framework of parallel joints in the finger and the electromechanical coupling equations of the piezoelectric material. Experiments are performed to elucidate the effect of the load resistance and the mouse click motion on energy harvesting.

  1. Linking Metal Ions via Inorganic Click (iClick) Reactions

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Veige, Adam

    2015-11-17

    This final report discusses the major objectives of the project, a discussion of the objectives achieved, a discussion of the objectives that failed, and finally, a discussion of future directions given the new knowledge obtained. This one-year seed project (with one year no-cost extension) contained three objectives: A) Expand the scope of iClick synthesis beyond AuI/AuI reactions. B) Elucidate a CuI-catalyzed iClick reaction. C) Synthesize and characterize tri- and tetra-metallic complexes as models for metallopolymers. Objectives A and C were achieved, whereas only parts of objective B were achieved.

  2. Realtime Hourly Data Table

    Science.gov Websites

    Tables View the latest hourly text summary CLICK ON UNDERLINED HOUR / SHADED BOX FOR THE LATEST CYCLE 00z Dump Tables View the latest rap text summary CLICK ON UNDERLINED HOUR / SHADED BOX FOR THE LATEST CYCLE Data Dump Tables View the latest model data text summary NAM GFS GDS CLICK ON UNDERLINED HOUR / SHADED

  3. Modeling User Behavior and Attention in Search

    ERIC Educational Resources Information Center

    Huang, Jeff

    2013-01-01

    In Web search, query and click log data are easy to collect but they fail to capture user behaviors that do not lead to clicks. As search engines reach the limits inherent in click data and are hungry for more data in a competitive environment, mining cursor movements, hovering, and scrolling becomes important. This dissertation investigates how…

  4. PMC's Florida Bay & Adjacent Marine Systems Science Program

    Science.gov Websites

    Florida Bay and Adjacent Marine Systems Science Program Inverted image, click link below to view actual image and caption click to display actual image and caption Program Overview Management & - January 2002 >For more, click here to view the What's New Page... | Main | Overview | Management &

  5. Comparison between ABR with click and narrow band chirp stimuli in children.

    PubMed

    Zirn, Stefan; Louza, Julia; Reiman, Viktor; Wittlinger, Natalie; Hempel, John-Martin; Schuster, Maria

    2014-08-01

    Click and chirp-evoked auditory brainstem responses (ABR) are applied for the estimation of hearing thresholds in children. The present study analyzes ABR thresholds across a large sample of children's ears obtained with both methods. The aim was to demonstrate the correlation between both methods using narrow band chirp and click stimuli. Click and chirp evoked ABRs were measured in 253 children aged from 0 to 18 years to determine their individual auditory threshold. The delay-compensated stimuli were narrow band CE chirps with either 2000 Hz or 4000 Hz center frequencies. Measurements were performed consecutively during natural sleep, and under sedation or general anesthesia. Threshold estimation was performed for each measurement by two experienced audiologists. Pearson-correlation analysis revealed highly significant correlations (r=0.94) between click and chirp derived thresholds for both 2 kHz and 4 kHz chirps. No considerable differences were observed either between different age ranges or gender. Comparing the thresholds estimated using ABR with click stimuli and chirp stimuli, only 0.8-2% for the 2000 Hz NB-chirp and 0.4-1.2% of the 4000 Hz NB-chirp measurements differed more than 15 dB for different degrees of hearing loss or normal hearing. The results suggest that either NB-chirp or click ABR is sufficient for threshold estimation. This holds for the chirp frequencies of 2000 Hz and 4000 Hz. The use of either click- or chirp-evoked ABR allows a reduction of recording time in young infants. Nevertheless, to cross-check the results of one of the methods, we recommend measurements with the other method as well. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  6. Discrimination of fast click-series produced by tagged Risso's dolphins (Grampus griseus) for echolocation or communication.

    PubMed

    Arranz, P; DeRuiter, S L; Stimpert, A K; Neves, S; Friedlaender, A S; Goldbogen, J A; Visser, F; Calambokidis, J; Southall, B L; Tyack, P L

    2016-09-15

    Early studies that categorized odontocete pulsed sounds had few means of discriminating signals used for biosonar-based foraging from those used for communication. This capability to identify the function of sounds is important for understanding and interpreting behavior; it is also essential for monitoring and mitigating potential disturbance from human activities. Archival tags were placed on free-ranging Grampus griseus to quantify and discriminate between pulsed sounds used for echolocation-based foraging and those used for communication. Two types of rapid click-series pulsed sounds, buzzes and burst pulses, were identified as produced by the tagged dolphins and classified using a Gaussian mixture model based on their duration, association with jerk (i.e. rapid change of acceleration) and temporal association with click trains. Buzzes followed regular echolocation clicks and coincided with a strong jerk signal from accelerometers on the tag. They consisted of series averaging 359±210 clicks (mean±s.d.) with an increasing repetition rate and relatively low amplitude. Burst pulses consisted of relatively short click series averaging 45±54 clicks with decreasing repetition rate and longer inter-click interval that were less likely to be associated with regular echolocation and the jerk signal. These results suggest that the longer, relatively lower amplitude, jerk-associated buzzes are used in this species to capture prey, mostly during the bottom phase of foraging dives, as seen in other odontocetes. In contrast, the shorter, isolated burst pulses that are generally emitted by the dolphins while at or near the surface are used outside of a direct, known foraging context. © 2016. Published by The Company of Biologists Ltd.

  7. Web Image Search Re-ranking with Click-based Similarity and Typicality.

    PubMed

    Yang, Xiaopeng; Mei, Tao; Zhang, Yong Dong; Liu, Jie; Satoh, Shin'ichi

    2016-07-20

    In image search re-ranking, besides the well known semantic gap, intent gap, which is the gap between the representation of users' query/demand and the real intent of the users, is becoming a major problem restricting the development of image retrieval. To reduce human effects, in this paper, we use image click-through data, which can be viewed as the "implicit feedback" from users, to help overcome the intention gap, and further improve the image search performance. Generally, the hypothesis visually similar images should be close in a ranking list and the strategy images with higher relevance should be ranked higher than others are widely accepted. To obtain satisfying search results, thus, image similarity and the level of relevance typicality are determinate factors correspondingly. However, when measuring image similarity and typicality, conventional re-ranking approaches only consider visual information and initial ranks of images, while overlooking the influence of click-through data. This paper presents a novel re-ranking approach, named spectral clustering re-ranking with click-based similarity and typicality (SCCST). First, to learn an appropriate similarity measurement, we propose click-based multi-feature similarity learning algorithm (CMSL), which conducts metric learning based on clickbased triplets selection, and integrates multiple features into a unified similarity space via multiple kernel learning. Then based on the learnt click-based image similarity measure, we conduct spectral clustering to group visually and semantically similar images into same clusters, and get the final re-rank list by calculating click-based clusters typicality and withinclusters click-based image typicality in descending order. Our experiments conducted on two real-world query-image datasets with diverse representative queries show that our proposed reranking approach can significantly improve initial search results, and outperform several existing re-ranking approaches.

  8. Evoked potential recording during echolocation in a false killer whale Pseudorca crassidens (L)

    NASA Astrophysics Data System (ADS)

    Supin, Alexander Ya.; Nachtigall, Paul E.; Pawloski, Jeffrey; Au, Whitlow W. L.

    2003-05-01

    Auditory brainstem responses (ABRs) were recorded in a false killer whale while the animal echolocated a target. The ABR collection was triggered by echolocation clicks of the animal. In these conditions, the recorded ABR pattern contained a duplicate set of waves. A comparison of ABR wave delays recorded during echolocation with those recorded during regular external stimulation with experimenter generated clicks showed that the first set of waves may be a response to the emitted click whereas the second one may be a response to the echo. Both responses, to the emitted click and to the echo, were of comparable amplitude in spite of the intensity difference of these two sounds that may differ by more than 40 dB near the animal's head. This finding indicates the presence of some mechanism of releasing responses to echoes from masking by loud emitted clicks. The evoked-potential method may be productive to investigate these mechanisms.

  9. Factors influencing clicking of banner ads on the WWW.

    PubMed

    Cho, Chang-Hoan

    2003-04-01

    This paper explores various factors influencing the clicking of banner ads on the WWW. The study indicates that several important variables affect the clicking of banner ads: (1) level of product involvement, (2) congruency between the content of a vehicle and the product category of a banner ad, (3) attitude toward the vehicle, and (4) overall attitude toward web advertising. For methodology, this study employed a between-group experimental design and measured real click-through rates with the aid of an online data collection technology called FileMaker Pro. Results of logistic regressions show that people are more likely to click banner ads if they are highly involved with products, perceive high synergy between web pages and ads, have a favorable attitude toward a vehicle, or have a favorable attitude toward web advertising in general. A total of 756 subjects participated in this research.

  10. Using a journal availability study to improve access

    PubMed Central

    Shaw-Kokot, Julia; de la Varre, Claire

    2001-01-01

    Purpose: Identify journal collection access and use factors. Setting and Subjects: University of North Carolina at Chapel Hill's Health Sciences Library patrons. Methodology: Survey forms and user interactions were monitored once a week for twelve weeks during the fall 1997 semester. The project was based on a 1989 New Mexico State University study and used Kantor's Branching Analysis to measure responses. Result: 80% of reported sought journal articles were found successfully. Along with journal usage data, the library obtained demographic and behavioral information. Discussion and Conclusions: Journals are the library's most used resource and, even as more electronic journals are offered, print journals continue to make up the majority of the collection. Several factors highlighted the need to study journal availability. User groups indicated that finding journals was problematic, and internal statistics showed people requesting interlibrary loans for owned items. The study looked at success rates, time, and ease of finding journals. A variety of reasons contributed to not finding journals. While overall user reports indicated relatively high success rate and satisfaction, there were problems to be addressed. As the library proceeds in redesigning both the physical space and electronic presence, the collected data have provided valuable direction. PMID:11209797

  11. Identification and analysis of unsatisfactory psychosocial work situations: a participatory approach employing video-computer interaction.

    PubMed

    Hanse, J J; Forsman, M

    2001-02-01

    A method for psychosocial evaluation of potentially stressful or unsatisfactory situations in manual work was developed. It focuses on subjective responses regarding specific situations and is based on interactive worker assessment when viewing video recordings of oneself. The worker is first video-recorded during work. The video is then displayed on the computer terminal, and the filmed worker clicks on virtual controls on the screen whenever an unsatisfactory psychosocial situation appears; a window of questions regarding psychological demands, mental strain and job control is then opened. A library with pictorial information and comments on the selected situations is formed in the computer. The evaluation system, called PSIDAR, was applied in two case studies, one of manual materials handling in an automotive workshop and one of a group of workers producing and testing instrument panels. The findings indicate that PSIDAR can provide data that are useful in a participatory ergonomic process of change.

  12. Thoth: Software for data visualization & statistics

    NASA Astrophysics Data System (ADS)

    Laher, R. R.

    2016-10-01

    Thoth is a standalone software application with a graphical user interface for making it easy to query, display, visualize, and analyze tabular data stored in relational databases and data files. From imported data tables, it can create pie charts, bar charts, scatter plots, and many other kinds of data graphs with simple menus and mouse clicks (no programming required), by leveraging the open-source JFreeChart library. It also computes useful table-column data statistics. A mature tool, having underwent development and testing over several years, it is written in the Java computer language, and hence can be run on any computing platform that has a Java Virtual Machine and graphical-display capability. It can be downloaded and used by anyone free of charge, and has general applicability in science, engineering, medical, business, and other fields. Special tools and features for common tasks in astronomy and astrophysical research are included in the software.

  13. Click Chemistry-Facilitated Structural Diversification of Nitrothiazoles, Nitrofurans, and Nitropyrroles Enhances Antimicrobial Activity against Giardia lamblia

    PubMed Central

    Kim, Wan Jung; Korthals, Keith A.; Li, Suhua; Le, Christine; Kalisiak, Jarosław; Sharpless, K. Barry; Fokin, Valery V.; Miyamoto, Yukiko

    2017-01-01

    ABSTRACT Giardia lamblia is an important and ubiquitous cause of diarrheal disease. The primary agents in the treatment of giardiasis are nitroheterocyclic drugs, particularly the imidazoles metronidazole and tinidazole and the thiazole nitazoxanide. Although these drugs are generally effective, treatment failures occur in up to 20% of cases, and resistance has been demonstrated in vivo and in vitro. Prior work had suggested that side chain modifications of the imidazole core can lead to new effective 5-nitroimidazole drugs that can combat nitro drug resistance, but the full potential of nitroheterocycles other than imidazole to yield effective new antigiardial agents has not been explored. Here, we generated derivatives of two clinically utilized nitroheterocycles, nitrothiazole and nitrofuran, as well as a third heterocycle, nitropyrrole, which is related to nitroimidazole but has not been systematically investigated as an antimicrobial drug scaffold. Click chemistry was employed to synthesize 442 novel nitroheterocyclic compounds with extensive side chain modifications. Screening of this library against representative G. lamblia strains showed a wide spectrum of in vitro activities, with many of the compounds exhibiting superior activity relative to reference drugs and several showing >100-fold increase in potency and the ability to overcome existing forms of metronidazole resistance. The majority of new compounds displayed no cytotoxicity against human cells, and several compounds were orally active against murine giardiasis in vivo. These findings provide additional impetus for the systematic development of nitroheterocyclic compounds with nonimidazole cores as alternative and improved agents for the treatment of giardiasis and potentially other infectious agents. PMID:28396548

  14. Click Chemistry-Facilitated Structural Diversification of Nitrothiazoles, Nitrofurans, and Nitropyrroles Enhances Antimicrobial Activity against Giardia lamblia.

    PubMed

    Kim, Wan Jung; Korthals, Keith A; Li, Suhua; Le, Christine; Kalisiak, Jarosław; Sharpless, K Barry; Fokin, Valery V; Miyamoto, Yukiko; Eckmann, Lars

    2017-06-01

    Giardia lamblia is an important and ubiquitous cause of diarrheal disease. The primary agents in the treatment of giardiasis are nitroheterocyclic drugs, particularly the imidazoles metronidazole and tinidazole and the thiazole nitazoxanide. Although these drugs are generally effective, treatment failures occur in up to 20% of cases, and resistance has been demonstrated in vivo and in vitro Prior work had suggested that side chain modifications of the imidazole core can lead to new effective 5-nitroimidazole drugs that can combat nitro drug resistance, but the full potential of nitroheterocycles other than imidazole to yield effective new antigiardial agents has not been explored. Here, we generated derivatives of two clinically utilized nitroheterocycles, nitrothiazole and nitrofuran, as well as a third heterocycle, nitropyrrole, which is related to nitroimidazole but has not been systematically investigated as an antimicrobial drug scaffold. Click chemistry was employed to synthesize 442 novel nitroheterocyclic compounds with extensive side chain modifications. Screening of this library against representative G. lamblia strains showed a wide spectrum of in vitro activities, with many of the compounds exhibiting superior activity relative to reference drugs and several showing >100-fold increase in potency and the ability to overcome existing forms of metronidazole resistance. The majority of new compounds displayed no cytotoxicity against human cells, and several compounds were orally active against murine giardiasis in vivo These findings provide additional impetus for the systematic development of nitroheterocyclic compounds with nonimidazole cores as alternative and improved agents for the treatment of giardiasis and potentially other infectious agents. Copyright © 2017 American Society for Microbiology.

  15. 76 FR 7564 - Notice of Public Information Collection(s) Being Submitted for Review and Approval to the Office...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-10

    ...'', (3) click on the downward-pointing arrow in the ``Select Agency'' box below the ``Currently Under... the ``Select Agency'' box, (5) click the ``Submit'' button to the right of the ``Select Agency'' box... its OMB Control Number, if there is one) and then click on the ICR Reference Number to view detailed...

  16. 76 FR 31331 - Information Collections Being Submitted for Review and Approval to the Office of Management and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-31

    ... ``Currently Under Review'', (3) click on the downward-pointing arrow in the ``Select Agency'' box below the... presented in the ``Select Agency'' box, (5) click the ``Submit'' button to the right of the ``Select Agency... (or its OMB Control Number, if there is one) and then click on the ICR Reference Number to view...

  17. 75 FR 1781 - Notice of Public Information Collection Being Submitted to the Office of Management and Budget...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-13

    ... the web page called ''Currently Under Review'', (3) click on the downward-pointing arrow in the... Commission'' from the list of agencies presented in the ''Select Agency'' box, (5) click the ''Submit... of this ICR (or its OMB Control Number, if there is one) and then click on the ICR. FOR FURTHER...

  18. View Submitted Projects | NOAA Gulf Spill Restoration

    Science.gov Websites

    that have been submitted to the trustees for consideration. To view details of an individual project , click the View icon on the list below or click the project marker on the map. To highlight the location of a project from the list, click the Show on Map icon. All projects that have met the posting

  19. Sex and Ear Differences in Spontaneous and Click-Evoked Otoacoustic Emissions in Young Adults

    ERIC Educational Resources Information Center

    Snihur, Adrian W. K.; Hampson, Elizabeth

    2011-01-01

    Effects of sex and handedness on the production of spontaneous and click-evoked otoacoustic emissions (OAEs) were explored in a non-hearing impaired population (ages 17-25 years). A sex difference in OAEs, either produced spontaneously (spontaneous OAEs or SOAEs) or in response to auditory stimuli (click-evoked OAEs or CEOAEs) has been reported in…

  20. Echolocation clicks from killer whales (Orcinus orca) feeding on herring (Clupea harengus).

    PubMed

    Simon, Malene; Wahlberg, Magnus; Miller, Lee A

    2007-02-01

    Echolocation clicks from Norwegian killer whales feeding on herring schools were recorded using a four-hydrophone array. The clicks had broadband bimodal frequency spectra with low and high frequency peaks at 24 and 108 kHz, respectively. The -10 dB bandwidth was 35 kHz. The average source level varied from 173 to 202 dB re 1 microPa (peak-to-peak) at 1 m. This is considerably lower than source levels described for Canadian killer whales foraging on salmon. It is suggested that biosonar clicks of Norwegian killer whales are adapted for localization of prey with high target strength and acute hearing abilities.

  1. Specific labeling of zinc finger proteins using noncanonical amino acids and copper-free click chemistry.

    PubMed

    Kim, Younghoon; Kim, Sung Hoon; Ferracane, Dean; Katzenellenbogen, John A; Schroeder, Charles M

    2012-09-19

    Zinc finger proteins (ZFPs) play a key role in transcriptional regulation and serve as invaluable tools for gene modification and genetic engineering. Development of efficient strategies for labeling metalloproteins such as ZFPs is essential for understanding and controlling biological processes. In this work, we engineered ZFPs containing cysteine-histidine (Cys2-His2) motifs by metabolic incorporation of the unnatural amino acid azidohomoalanine (AHA), followed by specific protein labeling via click chemistry. We show that cyclooctyne promoted [3 + 2] dipolar cycloaddition with azides, known as copper-free click chemistry, provides rapid and specific labeling of ZFPs at high yields as determined by mass spectrometry analysis. We observe that the DNA-binding activity of ZFPs labeled by conventional copper-mediated click chemistry was completely abolished, whereas ZFPs labeled by copper-free click chemistry retain their sequence-specific DNA-binding activity under native conditions, as determined by electrophoretic mobility shift assays, protein microarrays, and kinetic binding assays based on Förster resonance energy transfer (FRET). Our work provides a general framework to label metalloproteins such as ZFPs by metabolic incorporation of unnatural amino acids followed by copper-free click chemistry.

  2. Click- and chirp-evoked human compound action potentials

    PubMed Central

    Chertoff, Mark; Lichtenhan, Jeffery; Willis, Marie

    2010-01-01

    In the experiments reported here, the amplitude and the latency of human compound action potentials (CAPs) evoked from a chirp stimulus are compared to those evoked from a traditional click stimulus. The chirp stimulus was created with a frequency sweep to compensate for basilar membrane traveling wave delay using the O-Chirp equations from Fobel and Dau [(2004). J. Acoust. Soc. Am. 116, 2213–2222] derived from otoacoustic emission data. Human cochlear traveling wave delay estimates were obtained from derived compound band action potentials provided by Eggermont [(1979). J. Acoust. Soc. Am. 65, 463–470]. CAPs were recorded from an electrode placed on the tympanic membrane (TM), and the acoustic signals were monitored with a probe tube microphone attached to the TM electrode. Results showed that the amplitude and latency of chirp-evoked N1 of the CAP differed from click-evoked CAPs in several regards. For the chirp-evoked CAP, the N1 amplitude was significantly larger than the click-evoked N1s. The latency-intensity function was significantly shallower for chirp-evoked CAPs as compared to click-evoked CAPs. This suggests that auditory nerve fibers respond with more unison to a chirp stimulus than to a click stimulus. PMID:21117748

  3. Specific Labeling of Zinc Finger Proteins using Non-canonical Amino Acids and Copper-free Click Chemistry

    PubMed Central

    Kim, Younghoon; Kim, Sung Hoon; Ferracane, Dean; Katzenellenbogen, John A.

    2012-01-01

    Zinc finger proteins (ZFPs) play a key role in transcriptional regulation and serve as invaluable tools for gene modification and genetic engineering. Development of efficient strategies for labeling metalloproteins such as ZFPs is essential for understanding and controlling biological processes. In this work, we engineered ZFPs containing cysteine-histidine (Cys2-His2) motifs by metabolic incorporation of the unnatural amino acid azidohomoalanine (AHA), followed by specific protein labeling via click chemistry. We show that cyclooctyne promoted [3 + 2] dipolar cycloaddition with azides, known as copper-free click chemistry, provides rapid and specific labeling of ZFPs at high yields as determined by mass spectrometry analysis. We observe that the DNA-binding activity of ZFPs labeled by conventional copper-mediated click chemistry was completely abolished, whereas ZFPs labeled by copper-free click chemistry retain their sequence-specific DNA-binding activity under native conditions, as determined by electrophoretic mobility shift assays, protein microarrays and kinetic binding assays based on Förster resonance energy transfer (FRET). Our work provides a general framework to label metalloproteins such as ZFPs by metabolic incorporation of unnatural amino acids followed by copper-free click chemistry. PMID:22871171

  4. Forward-masking based gain control in odontocete biosonar: an evoked-potential study.

    PubMed

    Supin, Alexander Ya; Nachtigall, Paul E; Breese, Marlee

    2009-04-01

    Auditory evoked potentials (AEPs) were recorded during echolocation in a false killer whale Pseudorca crassidens. An electronically synthesized and played-back ("phantom") echo was used. Each electronic echo was triggered by an emitted biosonar pulse. The echo had a spectrum similar to that of the emitted biosonar clicks, and its intensity was proportional to that of the emitted click. The attenuation of the echo relative to the emitted click and its delay was controlled by the experimenter. Four combinations of echo attenuation and delay were tested (-31 dB, 2 ms), (-40 dB, 4 ms), (-49 dB, 8 ms), and (-58 dB, 16 ms); thus, attenuation and delay were associated with a rate of 9 dB of increased attenuation per delay doubling. AEPs related to emitted clicks displayed a regular amplitude dependence on the click level. Echo-related AEPs did not feature amplitude dependence on echo attenuation or emitted click levels, except in a few combinations of the lowest values of these two variables. The results are explained by a hypothesis that partial forward masking of the echoes by the preceding emitted sonar pulses serves as a kind of automatic gain control in the auditory system of echolocating odontocetes.

  5. Echolocation click rates and behavior of foraging Hawaiian spinner dolphins

    NASA Astrophysics Data System (ADS)

    Benoit-Bird, Kelly J.; Au, Whitlow W. L.

    2004-05-01

    Groups of spinner dolphins work together to actively aggregate small animals in the deep-scattering layer that serve as their prey. Detailed information on dolphin foraging behavior, obtained with a 200-kHz multibeam sonar (Simrad MS2000), made it possible to correlate echolocation and foraging. Fifty-six groups of spinner dolphins foraging at night within a midwater micronekton sound-scattering layer were observed with the sonar. During sonar surveys, the rates of whistles and echolocation clicks were measured using four hydrophones at 6-m depth intervals. Significant differences in click rates were found between depths and between the different stages of foraging. Groups of foraging dolphins ranged in size from 16 to 28 dolphins. Click rates were not significantly affected by the number of dolphins in a foraging group. Contrary to initial predictions, click rates were relatively low when sonar data indicated that pairs of dolphins were actively feeding. Highest echolocation rates occurred within the scattering layer, during transitions between foraging states. Whistles were only detected when dolphins were not in a foraging formation and when animals were surfacing. This suggests clicks may be used directly or indirectly to cue group movement during foraging.

  6. Postnatal development of echolocation abilities in a bottlenose dolphin (Tursiops truncatus): temporal organization.

    PubMed

    Favaro, Livio; Gnone, Guido; Pessani, Daniela

    2013-03-01

    In spite of all the information available on adult bottlenose dolphin (Tursiops truncatus) biosonar, the ontogeny of its echolocation abilities has been investigated very little. Earlier studies have reported that neonatal dolphins can produce both whistles and burst-pulsed sounds just after birth and that early-pulsed sounds are probably a precursor of echolocation click trains. The aim of this research is to investigate the development of echolocation signals in a captive calf, born in the facilities of the Acquario di Genova. A set of 81 impulsive sounds were collected from birth to the seventh postnatal week and six additional echolocation click trains were recorded when the dolphin was 1 year old. Moreover, behavioral observations, concurring with sound production, were carried out by means of a video camera. For each sound we measured five acoustic parameters: click train duration (CTD), number of clicks per train, minimum, maximum, and mean click repetition rate (CRR). CTD and number of clicks per train were found to increase with age. Maximum and mean CRR followed a decreasing trend with dolphin growth starting from the second postnatal week. The calf's first head scanning movement was recorded 21 days after birth. Our data suggest that in the bottlenose dolphin the early postnatal weeks are essential for the development of echolocation abilities and that the temporal features of the echolocation click trains remain relatively stable from the seventh postnatal week up to the first year of life. © 2013 Wiley Periodicals, Inc.

  7. Neonate Auditory Brainstem Responses to CE-Chirp and CE-Chirp Octave Band Stimuli I: Versus Click and Tone Burst Stimuli.

    PubMed

    Cobb, Kensi M; Stuart, Andrew

    The purpose of the study was to generate normative auditory brainstem response (ABR) wave component peak latency and amplitude values for neonates with air- and bone-conducted CE-Chirps and air-conducted CE-Chirp octave band stimuli (i.e., 500, 1000, 2000, and 4000 Hz). A second objective was to compare neonate ABRs to CE-Chirp stimuli with ABR responses to traditional click and tone burst stimuli with the same stimulus parameters. Participants were 168 healthy neonates. ABRs were obtained to air- and bone-conducted CE-Chirp and click stimuli and air-conducted CE-Chirp octave band and tone burst stimuli. The effects of stimulus level, rate, and polarity were examined with air-conducted CE-Chirps and clicks. The effect of stimulus level was also examined with bone-conducted CE-Chirps and clicks and air-conducted CE-Chirp octave band stimuli. In general, ABR wave V amplitudes to air- and bone-conducted CE-Chirp stimuli were significantly larger (p < 0.05) than those evoked to traditional click and tone burst stimuli. Systematic statistically significant (p < 0.05) wave V latency differences existed between the air- and bone-conducted CE-Chirp and CE-Chirp octave band stimuli relative to traditional click and tone burst stimuli. ABRs to air- and bone-conducted CE-Chirps and CE-Chirp octave band stimuli may be valuable in the assessment of newborn infants. However, the prognostic value of such stimuli needs to be validated.

  8. Homeland Security: A Selected Bibliography

    DTIC Science & Technology

    2011-04-01

    ProQuest Witzleb, Robert W., and Scott C . Truver. "Not Just a Bad Hair Day." [underwater mines] Proceedings: U.S. Naval Institute 134, no. 10...SAR) 18. NUMBER OF PAGES 35 19a. NAME OF RESPONSIBLE PERSON a. REPORT unclassified b. ABSTRACT unclassified c . THIS PAGE unclassified...IP_15_09_MigrationAndBorderSecurity.pdf Haddal, Chad C . Border Security: Key Agencies and Their Missions. Washington, DC: Library of Congress, Congressional Research Service

  9. Development and Testing of Recombinant Single Domain Antibodies

    DTIC Science & Technology

    2010-12-31

    critical insights to the basis of the sdAb-target interaction and sdAb properties. (a) Papers published in peer-reviewed journals (N/A for none) Structures...Library. Anal. Chem. 78:8245-55 List of papers submitted or published that acknowledge ARO support during this reporting period. List the papers ...including journal references, in the following categories: (b) Papers published in non-peer-reviewed journals or in conference proceedings (N/A for none

  10. Electronic Documents and Information: From Preservation to Access. Proceedings of the International Essen Symposium (18th, Essen, Germany, October 23-26, 1995). Publications of Essen University Library, No. 20.

    ERIC Educational Resources Information Center

    Helal, Ahmed H., Ed.; Weiss, Joachim W., Ed.

    The emphasis of this symposium was to examine national and international ways to preserve, access, and digitize human heritage and culture. Many internationally recognized librarians shared their experiences and ideas on that topic. The 19 papers presented at the symposium dealt with issues such as: the impact of new technologies on information…

  11. Journalists’ Privilege to Withhold Information in Judicial and Other Proceedings: State Shield Statutes

    DTIC Science & Technology

    2005-03-08

    Congressional Research Service ˜ The Library of Congress CRS Report for Congress Received through the CRS Web Order Code RL32806 Journalists ...currently valid OMB control number. 1. REPORT DATE 08 MAR 2005 2. REPORT TYPE N/A 3. DATES COVERED - 4. TITLE AND SUBTITLE Journalists ...State Shield Statutes Summary Absent a statutory or constitutional recognition of journalistic privilege, a reporter may be compelled to testify in legal

  12. Why Are Product Prices in Online Markets Not Converging?

    PubMed Central

    Mizuno, Takayuki; Watanabe, Tsutomu

    2013-01-01

    Why are product prices in online markets dispersed in spite of very small search costs? To address this question, we construct a unique dataset from a Japanese price comparison site, which records price quotes offered by e-retailers as well as customers’ clicks on products, which occur when they proceed to purchase the product. The novelty of our approach is that we seek to extract useful information on the source of price dispersion from the shape of price distributions rather than focusing merely on the standard deviation or the coefficient of variation of prices, as previous studies have done. We find that the distribution of prices retailers quote for a particular product at a particular point in time (divided by the lowest price) follows an exponential distribution, showing the presence of substantial price dispersion. For example, 20 percent of all retailers quote prices that are more than 50 percent higher than the lowest price. Next, comparing the probability that customers click on a retailer with a particular rank and the probability that retailers post prices at a particular rank, we show that both decline exponentially with price rank and that the exponents associated with the probabilities are quite close. This suggests that the reason why some retailers set prices at a level substantially higher than the lowest price is that they know that some customers will choose them even at that high price. Based on these findings, we hypothesize that price dispersion in online markets stems from heterogeneity in customers’ preferences over retailers; that is, customers choose a set of candidate retailers based on their preferences, which are heterogeneous across customers, and then pick a particular retailer among the candidates based on the price ranking. PMID:24015219

  13. Why are product prices in online markets not converging?

    PubMed

    Mizuno, Takayuki; Watanabe, Tsutomu

    2013-01-01

    Why are product prices in online markets dispersed in spite of very small search costs? To address this question, we construct a unique dataset from a Japanese price comparison site, which records price quotes offered by e-retailers as well as customers' clicks on products, which occur when they proceed to purchase the product. The novelty of our approach is that we seek to extract useful information on the source of price dispersion from the shape of price distributions rather than focusing merely on the standard deviation or the coefficient of variation of prices, as previous studies have done. We find that the distribution of prices retailers quote for a particular product at a particular point in time (divided by the lowest price) follows an exponential distribution, showing the presence of substantial price dispersion. For example, 20 percent of all retailers quote prices that are more than 50 percent higher than the lowest price. Next, comparing the probability that customers click on a retailer with a particular rank and the probability that retailers post prices at a particular rank, we show that both decline exponentially with price rank and that the exponents associated with the probabilities are quite close. This suggests that the reason why some retailers set prices at a level substantially higher than the lowest price is that they know that some customers will choose them even at that high price. Based on these findings, we hypothesize that price dispersion in online markets stems from heterogeneity in customers' preferences over retailers; that is, customers choose a set of candidate retailers based on their preferences, which are heterogeneous across customers, and then pick a particular retailer among the candidates based on the price ranking.

  14. Libraries: A Vision for the 90’s and Beyond. Proceedings of the Military Librarians Workshop (34th Annual), October 9-12, 1990

    DTIC Science & Technology

    1991-01-08

    10Ito 9 O.rQ t~~l.Itid the timew fW r~IwF’lnut~ ൓= 101144 "’stfl da fta ~W Reifvged wA~t4.nn- j this data h.eadŘd ad npJet-,,q and .ne,..n 114 I O=IIr.O...baughman, Dr. lDrivid it. Ibeudeir, Ihatherine l3lauer, James HI. 13yrn, Lois J . Carey and Mary B. Leveriing; ~nigahc of Library Customers 1990-2000, by Dr...Philip Ad.D 8011n-dtir; Libra ries in the Nineties and beyond, by Dr. TIhomas J . cialvin; I.-eadk’rshim Ill thom 90’s, by B~rooke E~. Sheldon

  15. In-Depth Indexing of Monograph Literature for an On-Line Retrieval System: A Pilot Project *

    PubMed Central

    Egeland, Janet

    1972-01-01

    One of the unique features of the State University of New York (SUNY) Biomedical Communication Network is the availability of depth-indexed monograph information for on-line retrieval. Approximately 8,000 titles from the Upstate Medical Center Library collection in Syracuse, New York, were indexed in depth, chapter-by-chapter, as to subject content using the control vocabulary Medical Subject Headings. Detailed indexing of monographic conference proceedings was considered of particular importance to the project. This attempt to make monograph literature more readily accessible to medical library patrons is interesting from both a philosophical and a technical point of view. This paper will discuss both of these aspects, giving an overall description of the nature of this innovative project. PMID:4403377

  16. Intracellular click reaction with a fluorescent chemical Ca2+ indicator to prolong its cytosolic retention.

    PubMed

    Takei, Yoshiaki; Murata, Atsushi; Yamagishi, Kento; Arai, Satoshi; Nakamura, Hideki; Inoue, Takafumi; Takeoka, Shinji

    2013-08-25

    The powerful strategy of "intracellular click reaction" was used to retain a chemical Ca(2+) indicator in the cytosol. Specifically, a novel clickable Ca(2+) indicator "N3-fura-2 AM" was coupled with dibenzylcyclooctyl-modified biomacromolecules via copper-free click reaction in living cells and Ca(2+) oscillation was observed for an extended period of time.

  17. Just Click It: Undergraduate Procedures for the Copper(I)-Catalyzed Formation of 1,2,3-Triazoles from Azides and Terminal Acetylenes

    ERIC Educational Resources Information Center

    Sharpless, William D.; Peng Wu; Hansen, Trond Vidar; Lindberg, James G.

    2005-01-01

    The click chemistry uses only the most reliable reactions to build complex molecules from olefins, electrophiles and heteroatom linkers. A variation on Huisgen's azide-alkyne 1,2,3-triazole synthesis, the addition of the copper (I), the premium example of the click reaction, catalyst strongly activates terminal acetylenes towards the 1,3-dipole in…

  18. 76 FR 33282 - Information Collections Being Submitted for Review and Approval to the Office of Management and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-08

    ... page called ``Currently Under Review'', (3) click on the downward-pointing arrow in the ``Select Agency...'' from the list of agencies presented in the ``Select Agency'' box, (5) click the ``Submit'' button to... appears, look for the title of this ICR (or its OMB Control Number, if there is one) and then click on the...

  19. Magnetic Nanoparticle-Based Imaging of RNA Transcripts in Breast Cancer Cells

    DTIC Science & Technology

    2009-06-01

    iron oxide NPs via thermal decomposition. - Prepared gold-coated iron oxide NPs. - Developed a click chemistry protocol (i.e. Cu-catalyzed terminal...D.L.J., Elias, D.R., Tsourkas, A. (2009) Comparative analysis of nanoparticle-antibody conjugations: carbodiimide versus click chemistry . Submitted...carbodiimide versus click chemistry . Submitted. APPENDICES: 1) Thorek, D.L.J., Tsourkas, A. (2008) Size, charge, and concentration dependent

  20. Construct validity and inter-rater reliability of the Dutch activity measure for post-acute care "6-clicks" basic mobility form to assess the mobility of hospitalized patients.

    PubMed

    Geelen, Sven Jacobus Gertruda; Valkenet, Karin; Veenhof, Cindy

    2018-05-12

    To evaluate the construct validity and the inter-rater reliability of the Dutch Activity Measure for Post-Acute Care "6-clicks" Basic Mobility short form measuring the patient's mobility in Dutch hospital care. First, the "6-clicks" was translated by using a forward-backward translation protocol. Next, 64 patients were assessed by the physiotherapist to determine the validity while being admitted to the Internal Medicine wards of a university medical center. Six hypotheses were tested regarding the construct "mobility" which showed that: Better "6-clicks" scores were related to less restrictive pre-admission living situations (p = 0.011), less restrictive discharge locations (p = 0.001), more independence in activities of daily living (p = 0.001) and less physiotherapy visits (p < 0.001). A correlation was found between the "6-clicks" and length of stay (r= -0.408, p = 0.001), but not between the "6-clicks" and age (r= -0.180, p = 0.528). To determine the inter-rater reliability, an additional 50 patients were assessed by pairs of physiotherapists who independently scored the patients. Intraclass Correlation Coefficients of 0.920 (95%CI: 0.828-0.964) were found. The Kappa Coefficients for the individual items ranged from 0.649 (walking stairs) to 0.841 (sit-to-stand). The Dutch "6-clicks" shows a good construct validity and moderate-to-excellent inter-rater reliability when used to assess the mobility of hospitalized patients. Implications for Rehabilitation Even though various measurement tools have been developed, it appears the majority of physiotherapists working in a hospital currently do not use these tools as a standard part of their care. The Activity Measure for Post-Acute Care "6-clicks" Basic Mobility is the only tool which is designed to be short, easy to use within usual care and has been validated in the entire hospital population. This study shows that the Dutch version of the Activity Measure for Post-Acute Care "6-clicks" Basic Mobility form is a valid, easy to use, quick tool to assess the basic mobility of Dutch hospitalized patients.

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