Science.gov

Sample records for clinical empirical studies

  1. Current Clinical Interventions for Smoking Cessation: A Review of Empirical Studies.

    ERIC Educational Resources Information Center

    Marcellino, Robert Leonard, Jr.

    This document reviews all empirical studies on clinically-based smoking cessation interventions that were reported in "Psychological Abstracts" between January 1982 and March 1990. Interventions are categorized as either physiological or psychological in orientation and are further grouped according to specific treatment type:…

  2. Psychopathy as a clinical and empirical construct.

    PubMed

    Hare, Robert D; Neumann, Craig S

    2008-01-01

    In this review, we focus on two major influences on current conceptualizations of psychopathy: one clinical, with its origins largely in the early case studies of Cleckley, and the other empirical, the result of widespread use of the Hare Psychopathy Checklist-Revised (PCL-R) for assessment purposes. Some investigators assert that the PCL-R, ostensibly based on Cleckley's work, has "drifted" from the construct described in his Clinical Profile. We evaluate this profile, note its basis in an unrepresentative sample of patients, and suggest that its literal and uncritical acceptance by the research community has become problematical. We also argue that the idea of construct "drift" is irrelevant to current conceptualizations of psychopathy, which are better informed by the extensive empirical research on the integration of structural, genetic, developmental, personality, and neurobiological research findings than by rigid adherence to early clinical formulations. We offer some suggestions for future research on psychopathy.

  3. Attitudes toward Substance Abuse Clients: An Empirical Study of Clinical Psychology Trainees

    PubMed Central

    Mundon, Chandra R.; Anderson, Melissa L.; Najavits, Lisa M.

    2015-01-01

    Despite the high prevalence of substance use disorder (SUD) and its frequent comorbidity with mental illness, individuals with SUD are less likely to receive effective SUD treatment from mental health practitioners than SUD counselors. Limited competence and interest in treating this clinical population is likely influenced by a lack of formal training in SUD treatment. Using a factorial survey-vignette design that included three clinical vignettes and a supplementary survey instrument, we investigated whether clinical psychology doctoral students differ in their level of negative emotional reactions toward clients with SUD versus major depressive disorder (MDD); whether they differ in their attributions for SUD versus MDD; and how their negative emotional reactions and attributions impact their interest in pursuing SUD clinical work. Participants were 155 clinical psychology graduate-level doctoral students (72% female). Participants endorsed more negative emotional reactions toward clients with SUD than toward clients with MDD. They were also more likely to identify poor willpower as the cause for SUD than for MDD. More than a third reported interest in working with SUD populations. Highest levels of interest were associated with prior professional and personal experience with SUD, four to six years of clinical experience, and postmodern theoretical orientation. PMID:26375324

  4. The role of the nurse teacher in clinical practice: an empirical study of Finnish student nurse experiences.

    PubMed

    Saarikoski, Mikko; Warne, Tony; Kaila, Päivi; Leino-Kilpi, Helena

    2009-08-01

    This paper focuses on the role of the nurse teacher (NT) in supporting student nurse education in clinical practice. The paper draws on the outcomes of a study aimed at exploring student nurse experiences of the pedagogical relationship with NTs during their clinical placements. The participants (N=549) were student nurses studying on pre-registration nursing programmes in Finland. Data were analysed using descriptive statistics, cross-tabulation and ANOVA. The study showed that the core aspect of NTs work in clinical practice revolved around the relationship between student, mentor and NT. Higher levels of satisfaction were experienced in direct proportion to the number of meetings held between the student and NT. However, whilst the importance of this relationship has been reported elsewhere, an additional aspect of this relationship emerged in the data analysis. Those NT who facilitated good face to face contact also used other methods to enhance the relationship, particularly e-mail, virtual learning environment and texting. This outcome suggests that NT's interpersonal and communicative skills are as important as their clinical knowledge and skills in promoting effective learning in the clinical practice area. The paper argues for such approaches to be utilised within the emergent opportunities afforded by new communication and educational technologies.

  5. Supervised methods for symptom name recognition in free-text clinical records of traditional Chinese medicine: an empirical study.

    PubMed

    Wang, Yaqiang; Yu, Zhonghua; Chen, Li; Chen, Yunhui; Liu, Yiguang; Hu, Xiaoguang; Jiang, Yongguang

    2014-02-01

    Clinical records of traditional Chinese medicine (TCM) are documented by TCM doctors during their routine diagnostic work. These records contain abundant knowledge and reflect the clinical experience of TCM doctors. In recent years, with the modernization of TCM clinical practice, these clinical records have begun to be digitized. Data mining (DM) and machine learning (ML) methods provide an opportunity for researchers to discover TCM regularities buried in the large volume of clinical records. There has been some work on this problem. Existing methods have been validated on a limited amount of manually well-structured data. However, the contents of most fields in the clinical records are unstructured. As a result, the previous methods verified on the well-structured data will not work effectively on the free-text clinical records (FCRs), and the FCRs are, consequently, required to be structured in advance. Manually structuring the large volume of TCM FCRs is time-consuming and labor-intensive, but the development of automatic methods for the structuring task is at an early stage. Therefore, in this paper, symptom name recognition (SNR) in the chief complaints, which is one of the important tasks to structure the FCRs of TCM, is carefully studied. The SNR task is reasonably treated as a sequence labeling problem, and several fundamental and practical problems in the SNR task are studied, such as how to adapt a general sequence labeling strategy for the SNR task according to the domain-specific characteristics of the chief complaints and which sequence classifier is more appropriate to solve the SNR task. To answer these questions, a series of elaborate experiments were performed, and the results are explained in detail.

  6. Clinical and economic outcomes of empiric parenteral antibiotic therapy for pneumonia: a retrospective study of 1,032 hospitalized patients.

    PubMed

    Bassi, O; Zuccarelli, S; Amalfitano, M E

    1998-10-01

    The spiraling increase in pharmaceutical costs in hospitals means that the economic aspects of pharmacological therapy can no longer be ignored. The aim of the present study was to evaluate care and cost outcomes following initial therapy with parenteral antibiotics in a hospital setting for the treatment of lower respiratory tract infection (pneumonia and pleurisy with or without complications). From January to December 1996, a total of 1,032 patients were reviewed. The mean age of the patients was 71.9 years (range, 16-100 years). Piperacillin was most frequently prescribed (n=369), followed by ceftriaxone (n=324) and ceftazidime (n=161), among other antibiotics. The clinical success ranged from a maximum of 85.0% and 85.4% for piperacillin and ceftriaxone, respectively, to a minimum of 72.7% and 75.2% for cefodizime and ciprofloxacin, respectively. Differences between the antibiotic regimens emerged for mean prescribed daily doses, therefore the daily cost per administered dose was much lower for antibiotics such as piperacillin or ceftriaxone than for cefotaxime or ceftazidime. Ceftriaxone, at just over 177,840 Italian liras per success, was more cost-effective than other third-generation cephalosporins such as ceftazidime and cefotaxime, whose cost-effectiveness ratios were 420,590 and 272,030 Italian liras, respectively. A comparison of cost ratios for the seven antibiotic regimens evaluated indicates that using ceftriaxone led to a 57.72% cost savings per clinical success compared to using other third generation cephalosporins such as ceftazidime, and a 69.45% savings compared to therapy with ciprofloxacin.

  7. Empirically supported psychological treatments: the challenge of evaluating clinical innovations.

    PubMed

    Church, Dawson; Feinstein, David; Palmer-Hoffman, Julie; Stein, Phyllis K; Tranguch, Anthony

    2014-10-01

    Clear and transparent standards are required to establish whether a therapeutic method is "evidence based." Even when research demonstrates a method to be efficacious, it may not become available to patients who could benefit from it, a phenomenon known as the "translational gap." Only 30% of therapies cross the gap, and the lag between empirical validation and clinical implementation averages 17 years. To address these problems, Division 12 of the American Psychological Association published a set of standards for "empirically supported treatments" in the mid-1990s that allows the assessment of clinical modalities. This article reviews these criteria, identifies their strengths, and discusses their impact on the translational gap, using the development of a clinical innovation called Emotional Freedom Techniques (EFT) as a case study. Twelve specific recommendations for updates of the Division 12 criteria are made based on lessons garnered from the adoption of EFT within the clinical community. These recommendations would shorten the cycle from the research setting to clinical practice, increase transparency, incorporate recent scientific advances, and enhance the capacity for succinct comparisons among treatments.

  8. The Clinical Assessment in the Legal Field: An Empirical Study of Bias and Limitations in Forensic Expertise.

    PubMed

    Iudici, Antonio; Salvini, Alessandro; Faccio, Elena; Castelnuovo, Gianluca

    2015-01-01

    According to the literature, psychological assessment in forensic contexts is one of the most controversial application areas for clinical psychology. This paper presents a review of systematic judgment errors in the forensic field. Forty-six psychological reports written by psychologists, court consultants, have been analyzed with content analysis to identify typical judgment errors related to the following areas: (a) distortions in the attribution of causality, (b) inferential errors, and (c) epistemological inconsistencies. Results indicated that systematic errors of judgment, usually referred also as "the man in the street," are widely present in the forensic evaluations of specialist consultants. Clinical and practical implications are taken into account. This article could lead to significant benefits for clinical psychologists who want to deal with this sensitive issue and are interested in improving the quality of their contribution to the justice system.

  9. The Clinical Assessment in the Legal Field: An Empirical Study of Bias and Limitations in Forensic Expertise

    PubMed Central

    Iudici, Antonio; Salvini, Alessandro; Faccio, Elena; Castelnuovo, Gianluca

    2015-01-01

    According to the literature, psychological assessment in forensic contexts is one of the most controversial application areas for clinical psychology. This paper presents a review of systematic judgment errors in the forensic field. Forty-six psychological reports written by psychologists, court consultants, have been analyzed with content analysis to identify typical judgment errors related to the following areas: (a) distortions in the attribution of causality, (b) inferential errors, and (c) epistemological inconsistencies. Results indicated that systematic errors of judgment, usually referred also as “the man in the street,” are widely present in the forensic evaluations of specialist consultants. Clinical and practical implications are taken into account. This article could lead to significant benefits for clinical psychologists who want to deal with this sensitive issue and are interested in improving the quality of their contribution to the justice system. PMID:26648892

  10. Direct Contra Naïve-Indirect Comparison of Clinical Failure Rates between High-Viscosity GIC and Conventional Amalgam Restorations: An Empirical Study

    PubMed Central

    Mickenautsch, Steffen; Yengopal, Veerasamy

    2013-01-01

    Background Naïve-indirect comparisons are comparisons between competing clinical interventions’ evidence from separate (uncontrolled) trials. Direct comparisons are comparisons within randomised control trials (RCTs). The objective of this empirical study is to test the null-hypothesis that trends and performance differences inferred from naïve-indirect comparisons and from direct comparisons/RCTs regarding the failure rates of amalgam and direct high-viscosity glass-ionomer cement (HVGIC) restorations in permanent posterior teeth have similar direction and magnitude. Methods A total of 896 citations were identified through systematic literature search. From these, ten and two uncontrolled clinical longitudinal studies for HVGIC and amalgam, respectively, were included for naïve-indirect comparison and could be matched with three out twenty RCTs. Summary effects sizes were computed as Odds ratios (OR; 95% Confidence intervals) and compared with those from RCTs. Trend directions were inferred from 95% Confidence interval overlaps and direction of point estimates; magnitudes of performance differences were inferred from the median point estimates (OR) with 25% and 75% percentile range, for both types of comparison. Mann-Whitney U test was applied to test for statistically significant differences between point estimates of both comparison types. Results Trends and performance differences inferred from naïve-indirect comparison based on evidence from uncontrolled clinical longitudinal studies and from direct comparisons based on RCT evidence are not the same. The distributions of the point estimates differed significantly for both comparison types (Mann–Whitney U  =  25, nindirect  =  26; ndirect  =  8; p  =  0.0013, two-tailed). Conclusion The null-hypothesis was rejected. Trends and performance differences inferred from either comparison between HVGIC and amalgam restorations failure rates in permanent posterior teeth are not the same. It is

  11. The relationship between the success rate of empirical antifungal therapy with intravenous itraconazole and clinical parameters, including plasma levels of itraconazole, in immunocompromised patients receiving itraconazole oral solution as prophylaxis: a multicenter, prospective, open-label, observational study in Korea.

    PubMed

    Kim, Jin Seok; Cheong, June-Won; Kim, Yeo-Kyeoung; Park, Jinny; Mun, Yeung-Chul; Kang, Hye Jin; Yi, Hyeon Gyu; Lee, Je-Hwan; Kim, Yang Soo; Ryoo, Hun-Mo; Kim, Sung-Hyun; Kim, Ho Young; Kim, Jin Young; Lee, Dong-Gun; Kim, Hoon-Gu; Kim, Hawk; Joo, Young-Don; Min, Yoo Hong

    2014-01-01

    To identify the role of therapeutic drug monitoring of itraconazole (ITZ) in the setting of empirical antifungal therapy with intravenous (IV) ITZ, we performed a multicenter, prospective study in patients with hematological malignancies who had received antifungal prophylaxis with ITZ oral solution (OS). We evaluated the plasma levels of ITZ and hydroxy (OH) ITZ both before initiation of IV ITZ and on days 5-7 of IV ITZ. A total of 181 patients showed an overall success rate of 68.0 %. Prolonged baseline neutropenia and accompanying cardiovascular comorbidity were significantly associated with poor outcomes of the empirical antifungal therapy (P = 0.005 and P = 0.001, respectively). A significantly higher trough plasma level of OH ITZ per body weight was found in the patients who achieved success with empirical antifungal therapy (P = 0.036). There were no significant correlations between plasma concentrations of ITZ/OH ITZ (baseline or trough levels) and toxicities. Seven patients had a discontinuation of ITZ therapy due to toxicity. This study demonstrated that IV ITZ as empirical antifungal therapy was effective and therapeutic drug monitoring was helpful to estimate the outcome of empirical antifungal therapy in patients receiving antifungal prophylaxis with ITZ OS. To predict the outcome of empirical antifungal therapy with IV ITZ, we should evaluate baseline clinical characteristics and also perform the therapeutic drug monitoring of both ITZ and OH ITZ.

  12. Comparative Case Study of Diffusion of Eye Movement Desensitization and Reprocessing in Two Clinical Settings: Empirically Supported Treatment Status Is Not Enough.

    PubMed

    Cook, Joan M; Biyanova, Tatyana; Coyne, James C

    2009-01-01

    An in-depth comparative case study was conducted of two attempts at diffusion of an empirically supported, but controversial, psychotherapy: eye movement desensitization and reprocessing (EMDR). One Department of Veterans Affairs (VA) treatment setting in which there was substantial uptake was compared with a second VA setting in which it was not adopted. Qualitative interviews were conducted with 10 mental health clinicians at the first site, and 19 at the second. Critical selling points for EMDR were a highly regarded champion, the observability of effects with patients, and personally experiencing its effects during a role training session. Compatibility with existing psychotherapist practices and values further allowed the therapy to become embedded in the organizational culture. At the second site, a sense that EMDR was not theoretically coherent or compelling overwhelmed other considerations, including its empirical status. Comparative studies contrasting settings in which innovative therapies are implemented versus those in which they were rejected may aid in refining theories of and strategies for dissemination.

  13. Characterizing Student Expectations: A Small Empirical Study

    ERIC Educational Resources Information Center

    Warwick, Jonathan

    2016-01-01

    This paper describes the results of a small empirical study (n = 130), in which undergraduate students in the Business Faculty of a UK university were asked to express views and expectations relating to the study of a mathematics. Factor analysis is used to identify latent variables emerging from clusters of the measured variables and these are…

  14. Clinical Findings and Pain Symptoms as Potential Risk Factors for Chronic TMD: Descriptive Data and Empirically Identified Domains from the OPPERA Case-Control Study

    PubMed Central

    Ohrbach, Richard; Fillingim, Roger B.; Mulkey, Flora; Gonzalez, Yoly; Gordon, Sharon; Gremillion, Henry; Lim, Pei-Feng; Ribeiro-Dasilva, Margarete; Greenspan, Joel D.; Knott, Charles; Maixner, William; Slade, Gary

    2011-01-01

    Clinical characteristics might be associated with temporomandibular disorders (TMD) because they are antecedent risk factors that increase the likelihood of a healthy person developing the condition or because they represent signs or symptoms of either subclinical or overt TMD. In this baseline case-control study of the multisite Orofacial Pain: Prospective Evaluation and Risk Assessment (OPPERA) project, 1,633 controls and 185 cases with chronic, painful TMD completed questionnaires and received clinical examinations. Odds ratios measuring association between each clinical factor and TMD were computed, with adjustment for study-site as well as age, sex, and race/ethnicity. Compared to controls, TMD cases reported more trauma, greater parafunction, more headaches and other pain disorders, more functional limitation in using the jaw, more nonpain symptoms in the facial area, more temporomandibular joint noises and jaw locking, more neural or sensory medical conditions, and worse overall medical status. They also exhibited on examination reduced jaw mobility, more joint noises, and a greater number of painful masticatory, cervical, and body muscles upon palpation. The results indicated that TMD cases differ substantially from controls across almost all variables assessed. Future analyses of follow-up data will determine whether these clinical characteristics predict increased risk for developing first-onset pain-related TMD Perspective Clinical findings from OPPERA’s baseline case-control study indicate significant differences between chronic TMD cases and controls with respect to trauma history, parafunction, other pain disorders, health status, and clinical examination data. Future analyses will examine their contribution to TMD onset. PMID:22074750

  15. A Comparison of Clinical and Empirical Literature on Children in Stepfamilies.

    ERIC Educational Resources Information Center

    Ganong, Lawrence H.; Coleman, Marilyn

    1986-01-01

    Reviewed the literature on stepchildren and compared clinical to empirical research. Comparisons were made on theoretical approaches, methodology, types of stepfamilies, issues and dependent variables examined, other variables considered, and conclusions drawn. There was little congruence in the foci of studies by researchers and clinicians.…

  16. [Hospital costs: results of empirical studies].

    PubMed

    Delande, G; Negre, M

    1992-01-01

    The DRG hospital payment system will be introduced in France in 1993-94 under the name of GHM ("groupes homogènes de malades"). However the method for evaluating costs is mainly based on past trends and, as a matter of fact, they exclude innovative care behavior from the doctors. Three new methods are therefore experimented: (i) standardized operation protocols; (ii) observation of consumed products and time of health personnel; (iii) observation of the costs resulting from the tariffs of the Social Security administration. The empirical studies were carried out in Montpellier and Nantes, two middle size cities of France.

  17. An Empirical Study of Enterprise Conceptual Modeling

    NASA Astrophysics Data System (ADS)

    Anaby-Tavor, Ateret; Amid, David; Fisher, Amit; Ossher, Harold; Bellamy, Rachel; Callery, Matthew; Desmond, Michael; Krasikov, Sophia; Roth, Tova; Simmonds, Ian; de Vries, Jacqueline

    Business analysts, business architects, and solution consultants use a variety of practices and methods in their quest to understand business. The resulting work products could end up being transitioned into the formal world of software requirement definitions or as recommendations for all kinds of business activities. We describe an empirical study about the nature of these methods, diagrams, and home-grown conceptual models as reflected in real practice at IBM. We identify the models as artifacts of "enterprise conceptual modeling". We study important features of these models, suggest practical classifications, and discuss their usage. Our survey shows that the "enterprise conceptual modeling" arena presents a variety of descriptive models, each used by a relatively small group of colleagues. Together they form a "long tail" that extends from "drawings" on one end to "standards" on the other.

  18. An empirical study of software design practices

    NASA Technical Reports Server (NTRS)

    Card, David N.; Church, Victor E.; Agresti, William W.

    1986-01-01

    Software engineers have developed a large body of software design theory and folklore, much of which was never validated. The results of an empirical study of software design practices in one specific environment are presented. The practices examined affect module size, module strength, data coupling, descendant span, unreferenced variables, and software reuse. Measures characteristic of these practices were extracted from 887 FORTRAN modules developed for five flight dynamics software projects monitored by the Software Engineering Laboratory (SEL). The relationship of these measures to cost and fault rate was analyzed using a contingency table procedure. The results show that some recommended design practices, despite their intuitive appeal, are ineffective in this environment, whereas others are very effective.

  19. Empirical study of recent Chinese stock market

    NASA Astrophysics Data System (ADS)

    Jiang, J.; Li, W.; Cai, X.; Wang, Qiuping A.

    2009-05-01

    We investigate the statistical properties of the empirical data taken from the Chinese stock market during the time period from January, 2006 to July, 2007. By using the methods of detrended fluctuation analysis (DFA) and calculating correlation coefficients, we acquire the evidence of strong correlations among different stock types, stock index, stock volume turnover, A share (B share) seat number, and GDP per capita. In addition, we study the behavior of “volatility”, which is now defined as the difference between the new account numbers for two consecutive days. It is shown that the empirical power-law of the number of aftershock events exceeding the selected threshold is analogous to the Omori law originally observed in geophysics. Furthermore, we find that the cumulative distributions of stock return, trade volume and trade number are all exponential-like, which does not belong to the universality class of such distributions found by Xavier Gabaix et al. [Xavier Gabaix, Parameswaran Gopikrishnan, Vasiliki Plerou, H. Eugene Stanley, Nature, 423 (2003)] for major western markets. Through the comparison, we draw a conclusion that regardless of developed stock markets or emerging ones, “cubic law of returns” is valid only in the long-term absolute return, and in the short-term one, the distributions are exponential-like. Specifically, the distributions of both trade volume and trade number display distinct decaying behaviors in two separate regimes. Lastly, the scaling behavior of the relation is analyzed between dispersion and the mean monthly trade value for each administrative area in China.

  20. Transition mixing study empirical model report

    NASA Technical Reports Server (NTRS)

    Srinivasan, R.; White, C.

    1988-01-01

    The empirical model developed in the NASA Dilution Jet Mixing Program has been extended to include the curvature effects of transition liners. This extension is based on the results of a 3-D numerical model generated under this contract. The empirical model results agree well with the numerical model results for all tests cases evaluated. The empirical model shows faster mixing rates compared to the numerical model. Both models show drift of jets toward the inner wall of a turning duct. The structure of the jets from the inner wall does not exhibit the familiar kidney-shaped structures observed for the outer wall jets or for jets injected in rectangular ducts.

  1. Evolution of viral virulence: empirical studies

    USGS Publications Warehouse

    Kurath, Gael; Wargo, Andrew R.

    2016-01-01

    The concept of virulence as a pathogen trait that can evolve in response to selection has led to a large body of virulence evolution theory developed in the 1980-1990s. Various aspects of this theory predict increased or decreased virulence in response to a complex array of selection pressures including mode of transmission, changes in host, mixed infection, vector-borne transmission, environmental changes, host vaccination, host resistance, and co-evolution of virus and host. A fundamental concept is prediction of trade-offs between the costs and benefits associated with higher virulence, leading to selection of optimal virulence levels. Through a combination of observational and experimental studies, including experimental evolution of viruses during serial passage, many of these predictions have now been explored in systems ranging from bacteriophage to viruses of plants, invertebrates, and vertebrate hosts. This chapter summarizes empirical studies of viral virulence evolution in numerous diverse systems, including the classic models myxomavirus in rabbits, Marek's disease virus in chickens, and HIV in humans. Collectively these studies support some aspects of virulence evolution theory, suggest modifications for other aspects, and show that predictions may apply in some virus:host interactions but not in others. Finally, we consider how virulence evolution theory applies to disease management in the field.

  2. Empiric Antibiotic Treatment of Erythema Migrans-Like Skin Lesions As a Function of Geography: A Clinical and Cost Effectiveness Modeling Study

    PubMed Central

    Brinkerhoff, R. Jory; Wormser, Gary P.; Clemen, Robert

    2013-01-01

    Abstract The skin lesion of early Lyme disease, erythema migrans (EM), is so characteristic that routine practice is to treat all such patients with antibiotics. Because other skin lesions may resemble EM, it is not known whether presumptive treatment of EM is appropriate in regions where Lyme disease is rare. We constructed a decision model to compare the cost and clinical effectiveness of three strategies for the management of EM: Treat All, Observe, and Serology as a function of the probability that an EM-like lesion is Lyme disease. Treat All was found to be the preferred strategy in regions that are endemic for Lyme disease. Where Lyme disease is rare, Observe is the preferred strategy, as presumptive treatment would be expected to produce excessive harm and increased costs. Where Lyme disease is rare, clinicians and public health officials should consider observing patients with EM-like lesions who lack travel to Lyme disease-endemic areas. PMID:24107201

  3. Empiric antibiotic treatment of erythema migrans-like skin lesions as a function of geography: a clinical and cost effectiveness modeling study.

    PubMed

    Lantos, Paul M; Brinkerhoff, R Jory; Wormser, Gary P; Clemen, Robert

    2013-12-01

    The skin lesion of early Lyme disease, erythema migrans (EM), is so characteristic that routine practice is to treat all such patients with antibiotics. Because other skin lesions may resemble EM, it is not known whether presumptive treatment of EM is appropriate in regions where Lyme disease is rare. We constructed a decision model to compare the cost and clinical effectiveness of three strategies for the management of EM: Treat All, Observe, and Serology as a function of the probability that an EM-like lesion is Lyme disease. Treat All was found to be the preferred strategy in regions that are endemic for Lyme disease. Where Lyme disease is rare, Observe is the preferred strategy, as presumptive treatment would be expected to produce excessive harm and increased costs. Where Lyme disease is rare, clinicians and public health officials should consider observing patients with EM-like lesions who lack travel to Lyme disease-endemic areas.

  4. Forum report: issues in clinical trials of empirical antifungal therapy in treating febrile neutropenic patients.

    PubMed

    Bennett, John E; Powers, John; Walsh, Thomas; Viscoli, Claudio; de Pauw, Ben; Dismukes, William; Galgiani, John; Glauser, Michel; Herbrecht, Raoul; Kauffman, Carol; Lee, Jeannette; Pappas, Peter; Rex, John; Verweij, Paul

    2003-04-15

    There is inferential evidence that some patients with prolonged neutropenia and fever not responding to antibacterial agents are at sufficient risk of deep mycoses to warrant empirical therapy, although superiority of an antifungal agent over placebo has not been conclusively demonstrated. Amphotericin B deoxycholate, liposomal amphotericin B, and intravenous itraconazole followed by oral itraconazole solution are licensed in the United States for this indication. Fluconazole and voriconazole have given favorable results in clinical trials of patients with low and high risk of deep mold infections, respectively. Design features that can profoundly influence outcome of empirical trials are (1) inclusion of low-risk patients, (2) failure to blind the study, (3) obscuration of antifungal effects by changing antibacterial antibiotics, (4) failure to balance both arms of the study in terms of patients with prior antifungal prophylaxis or with severe comorbidities, (5) the merging of end points evaluating safety with those of efficacy, and (6) choice of different criteria for resolution of fever.

  5. An empirical study of scanner system parameters

    NASA Technical Reports Server (NTRS)

    Landgrebe, D.; Biehl, L.; Simmons, W.

    1976-01-01

    The selection of the current combination of parametric values (instantaneous field of view, number and location of spectral bands, signal-to-noise ratio, etc.) of a multispectral scanner is a complex problem due to the strong interrelationship these parameters have with one another. The study was done with the proposed scanner known as Thematic Mapper in mind. Since an adequate theoretical procedure for this problem has apparently not yet been devised, an empirical simulation approach was used with candidate parameter values selected by the heuristic means. The results obtained using a conventional maximum likelihood pixel classifier suggest that although the classification accuracy declines slightly as the IFOV is decreased this is more than made up by an improved mensuration accuracy. Further, the use of a classifier involving both spatial and spectral features shows a very substantial tendency to resist degradation as the signal-to-noise ratio is decreased. And finally, further evidence is provided of the importance of having at least one spectral band in each of the major available portions of the optical spectrum.

  6. Women's Studies at Empire State College.

    ERIC Educational Resources Information Center

    Lester, Virginia L.

    Because of the unique program of Empire State College, the problem of providing compensatory courses about women and developing a strategy for eventually having them incorporated into the curriculum of a discipline has been avoided. The focus at this college has been taken from the teacher and placed on the student, giving the student the primary…

  7. [Assumption of projective reduplication in psychosomatic patients. I. Results of an empirical study].

    PubMed

    Ullrich, G

    1988-01-01

    The starting position of this study was the striking discrepancy between clinical hypothesis on "projective reduplication" and their empirical validation. Empirical data for the statistical analysis derived from a heterogeneous group of psychosomatically ill persons (N = 33) and a group of normal controls (N = 30). Using the similarity of the image of one's self and the one of others as an experimental analogy of the "projective reduplication", we could not ascertain any verifying hint for this syndrome. The results of the present study do not support the assumption of a clinical phenomenon according to the hypotheses tested. But it still remains uncertain whether these hypotheses are appropriate transformations of clinical experience.

  8. Placing clinical variables on a common linear scale of empirically based risk as a step towards construction of a general patient acuity score from the electronic health record: a modelling study

    PubMed Central

    Rothman, Steven I; Rothman, Michael J; Solinger, Alan B

    2013-01-01

    Objective To explore the hypothesis that placing clinical variables of differing metrics on a common linear scale of all-cause postdischarge mortality provides risk functions that are directly correlated with in-hospital mortality risk. Design Modelling study. Setting An 805-bed community hospital in the southeastern USA. Participants 42302 inpatients admitted for any reason, excluding obstetrics, paediatric and psychiatric patients. Outcome measures All-cause in-hospital and postdischarge mortalities, and associated correlations. Results Pearson correlation coefficients comparing in-hospital risks with postdischarge risks for creatinine, heart rate and a set of 12 nursing assessments are 0.920, 0.922 and 0.892, respectively. Correlation between postdischarge risk heart rate and the Modified Early Warning System (MEWS) component for heart rate is 0.855. The minimal excess risk values for creatinine and heart rate roughly correspond to the normal reference ranges. We also provide the risks for values outside that range, independent of expert opinion or a regression model. By summing risk functions, a first-approximation patient risk score is created, which correctly ranks 6 discharge categories by average mortality with p<0.001 for differences in category means, and Tukey's Honestly Significant Difference Test confirmed that the means were all different at the 95% confidence level. Conclusions Quantitative or categorical clinical variables can be transformed into risk functions that correlate well with in-hospital risk. This methodology provides an empirical way to assess inpatient risk from data available in the Electronic Health Record. With just the variables in this paper, we achieve a risk score that correlates with discharge disposition. This is the first step towards creation of a universal measure of patient condition that reflects a generally applicable set of health-related risks. More importantly, we believe that our approach opens the door to a way of

  9. Empathy in Narcissistic Personality Disorder: From Clinical and Empirical Perspectives

    PubMed Central

    Baskin-Sommers, Arielle; Krusemark, Elizabeth; Ronningstam, Elsa

    2015-01-01

    Narcissistic personality disorder (NPD) is associated with an assortment of characteristics that undermine interpersonal functioning. A lack of empathy is often cited as the primary distinguishing feature of NPD. However, clinical presentations of NPD suggest that empathy is not simply deficient in these individuals, but dysfunctional and subject to a diverse set of motivational and situational factors. Consistent with this presentation, research illustrates that empathy is multidimensional, involving 2 distinct emotional and cognitive processes associated with a capacity to respectively understand and respond to others’ mental and affective states. The goal of this practice review is to bridge the gap between our psychobiological understanding of empathy and its clinical manifestations in NPD. We present 3 case studies highlighting the variability in empathic functioning in people with NPD. Additionally, we summarize the literature on empathy and NPD, which largely associates this disorder with deficient emotional empathy, and dysfunctional rather than deficient cognitive empathy. Because this research is limited, we also present empathy-based findings for related syndromes (borderline and psychopathy). Given the complexity of narcissism and empathy, we propose that multiple relationships can exist between these constructs. Ultimately, by recognizing the multifaceted relationship between empathy and narcissism, and moving away from an all or nothing belief that those with NPD simply lack empathy, therapists may better understand narcissistic patients’ behavior and motivational structure. PMID:24512457

  10. Empathy in narcissistic personality disorder: from clinical and empirical perspectives.

    PubMed

    Baskin-Sommers, Arielle; Krusemark, Elizabeth; Ronningstam, Elsa

    2014-07-01

    Narcissistic personality disorder (NPD) is associated with an assortment of characteristics that undermine interpersonal functioning. A lack of empathy is often cited as the primary distinguishing feature of NPD. However, clinical presentations of NPD suggest that empathy is not simply deficient in these individuals, but dysfunctional and subject to a diverse set of motivational and situational factors. Consistent with this presentation, research illustrates that empathy is multidimensional, involving 2 distinct emotional and cognitive processes associated with a capacity to respectively understand and respond to others' mental and affective states. The goal of this practice review is to bridge the gap between our psychobiological understanding of empathy and its clinical manifestations in NPD. We present 3 case studies highlighting the variability in empathic functioning in people with NPD. Additionally, we summarize the literature on empathy and NPD, which largely associates this disorder with deficient emotional empathy, and dysfunctional rather than deficient cognitive empathy. Because this research is limited, we also present empathy-based findings for related syndromes (borderline and psychopathy). Given the complexity of narcissism and empathy, we propose that multiple relationships can exist between these constructs. Ultimately, by recognizing the multifaceted relationship between empathy and narcissism, and moving away from an all or nothing belief that those with NPD simply lack empathy, therapists may better understand narcissistic patients' behavior and motivational structure.

  11. Empirical studies on changes in oil governance

    NASA Astrophysics Data System (ADS)

    Kemal, Mohammad

    Regulation of the oil and gas sector is consequential to the economies of oil-producing countries. In the literature, there are two types of regulation: indirect regulation through taxes and tariffs or direct regulation through the creation of a National Oil Company (NOC). In the 1970s, many oil-producing countries nationalized their oil and gas sectors by creating and giving ownership rights of oil and gas resources to NOCs. In light of the success of Norway in regulating its oil and gas resources, over the past two decades several countries have changed their oil governance by changing the rights given to NOC from ownership right to mere access rights like other oil companies. However, empirical literature on these changes in oil governance is quite thin. Thus, this dissertation will explore three research questions to investigate empirically these changes in oil governance. First, I investigate empirically the impact of the changes in oil governance on aggregate domestic income. By employing a difference-in-difference method, I will show that a country which changed its oil governance increases its GDP per-capita by 10%. However, the impact is different for different types of political institution. Second, by observing the changes in oil governance in Indonesia , I explore the impact of the changes on learning-by-doing and learning spillover effect in offshore exploration drilling. By employing an econometric model which includes interaction terms between various experience variables and changes in an oil governance dummy, I will show that the change in oil governance in Indonesia enhances learning-by-doing by the rigs and learning spillover in a basin. Lastly, the impact of the changes in oil governance on expropriation risk and extraction path will be explored. By employing a difference-in-difference method, this essay will show that the changes in oil governance reduce expropriation and the impact of it is different for different sizes of resource stock.

  12. The German specimen case, Amalia X: empirical studies.

    PubMed

    Kächele, Horst; Albani, Cornelia; Buchheim, Anna; Hölzer, Michael; Hohage, Roderich; Mergenthaler, Erhard; Jiménez, Juan Pablo; Leuzinger-Bohleber, Marianne; Neudert-Dreyer, Lisbeth; Pokorny, Dan; Thomä, Helmut

    2006-06-01

    The authors provide a perspective on how psychoanalytic process research can be implemented. This is based on a process research model described elsewhere and summarizes the kinds of studies that can be situated on the four levels of the model. The authors summarize multiple empirical studies that were performed in a completely tape-recorded psychoanalytic therapy and have been published. These studies demonstrate the many modalities empirical process research has available to objectively study psychoanalytic process phenomena and their implication for outcome.

  13. Classifier calibration using splined empirical probabilities in clinical risk prediction.

    PubMed

    Gaudoin, René; Montana, Giovanni; Jones, Simon; Aylin, Paul; Bottle, Alex

    2015-06-01

    The aims of supervised machine learning (ML) applications fall into three broad categories: classification, ranking, and calibration/probability estimation. Many ML methods and evaluation techniques relate to the first two. Nevertheless, there are many applications where having an accurate probability estimate is of great importance. Deriving accurate probabilities from the output of a ML method is therefore an active area of research, resulting in several methods to turn a ranking into class probability estimates. In this manuscript we present a method, splined empirical probabilities, based on the receiver operating characteristic (ROC) to complement existing algorithms such as isotonic regression. Unlike most other methods it works with a cumulative quantity, the ROC curve, and as such can be tagged onto an ROC analysis with minor effort. On a diverse set of measures of the quality of probability estimates (Hosmer-Lemeshow, Kullback-Leibler divergence, differences in the cumulative distribution function) using simulated and real health care data, our approach compares favourably with the standard calibration method, the pool adjacent violators algorithm used to perform isotonic regression.

  14. Clinical Feedback About Empirically Supported Treatments for Obsessive-Compulsive Disorder.

    PubMed

    Jacobson, Nicholas C; Newman, Michelle G; Goldfried, Marvin R

    2016-01-01

    Previous evidence for the treatment of obsessive-compulsive disorder (OCD) has been derived principally from randomized controlled trials. As such, evidence about the treatment of OCD has unilaterally flowed from researchers to clinicians. Despite often having decades of experience treating OCD, clinicians' feedback on their clinical observations in using these treatments has not been solicited. The current study contacted clinicians for their clinical observations on empirically supported treatments for OCD to identify commonly used cognitive-behavioral techniques and their limitations in their practices. One hundred eighty-one psychotherapists completed an online survey. The average participant practiced psychotherapy for 15 years, worked in private practice, held a doctorate, and treated an average of 25 clients with OCD in their lifetime. In regard to the most common techniques, behavioral strategies involving exposure to a feared outcome and prevention of a compulsive ritual were the most frequent group of interventions, followed by techniques that attempted to identify and challenge irrational thoughts. However, the majority of participants also reported incorporating mindfulness or acceptance-based methods. Based on therapists' reports, the most common barriers to the efficacy of cognitive-behavioral interventions included limited premorbid functioning, chaotic lifestyles, controlling and critical families, OCD symptom severity, OCD symptom chronicity, and comorbidities. This study provides insight into common practices and limitations in clinical practice to inform future clinically relevant treatment research.

  15. Dissociative absorption: An empirically unique, clinically relevant, dissociative factor.

    PubMed

    Soffer-Dudek, Nirit; Lassri, Dana; Soffer-Dudek, Nir; Shahar, Golan

    2015-11-01

    Research of dissociative absorption has raised two questions: (a) Is absorption a unique dissociative factor within a three-factor structure, or a part of one general dissociative factor? Even when three factors are found, the specificity of the absorption factor is questionable. (b) Is absorption implicated in psychopathology? Although commonly viewed as "non-clinical" dissociation, absorption was recently hypothesized to be specifically associated with obsessive-compulsive symptoms. To address these questions, we conducted exploratory and confirmatory factor analyses on 679 undergraduates. Analyses supported the three-factor model, and a "purified" absorption scale was extracted from the original inclusive absorption factor. The purified scale predicted several psychopathology scales. As hypothesized, absorption was a stronger predictor of obsessive-compulsive symptoms than of general psychopathology. In addition, absorption was the only dissociative scale that longitudinally predicted obsessive-compulsive symptoms. We conclude that absorption is a unique and clinically relevant dissociative tendency that is particularly meaningful to obsessive-compulsive symptoms.

  16. A regulatory model for clinical laboratories: an empirical evaluation.

    PubMed

    Peddecord, K M

    1989-04-01

    Clinical laboratories in the United States are subject to various regulatory and accreditation programs, which mandate a broad range of requirements regarding personnel, quality-control systems, and analytical proficiency standards. Reported here, for a cross-section of U.S. laboratories, is the degree of compliance with these regulatory requirements, some other laboratory characteristics, and their relation to analytical proficiency. The results suggest that those laboratory characteristics that predict highest proficiency-test performance differ for each laboratory specialty. Regression models are presented that explain from 12% to 35% of the variation in analytical performance and suggest that factors outside of those specified in the regulatory model and other characteristics measured in this research are important. Indeed, the current regulatory approach may not ensure highest performance. Also discussed are the current status, limitations, and prospects for change of the clinical laboratory regulatory system.

  17. An Empirical Study for Impacts of Measurement Errors on EHR based Association Studies

    PubMed Central

    Duan, Rui; Cao, Ming; Wu, Yonghui; Huang, Jing; Denny, Joshua C; Xu, Hua; Chen, Yong

    2016-01-01

    Over the last decade, Electronic Health Records (EHR) systems have been increasingly implemented at US hospitals. Despite their great potential, the complex and uneven nature of clinical documentation and data quality brings additional challenges for analyzing EHR data. A critical challenge is the information bias due to the measurement errors in outcome and covariates. We conducted empirical studies to quantify the impacts of the information bias on association study. Specifically, we designed our simulation studies based on the characteristics of the Electronic Medical Records and Genomics (eMERGE) Network. Through simulation studies, we quantified the loss of power due to misclassifications in case ascertainment and measurement errors in covariate status extraction, with respect to different levels of misclassification rates, disease prevalence, and covariate frequencies. These empirical findings can inform investigators for better understanding of the potential power loss due to misclassification and measurement errors under a variety of conditions in EHR based association studies. PMID:28269935

  18. Empirical study on human acupuncture point network

    NASA Astrophysics Data System (ADS)

    Li, Jian; Shen, Dan; Chang, Hui; He, Da-Ren

    2007-03-01

    Chinese medical theory is ancient and profound, however is confined by qualitative and faint understanding. The effect of Chinese acupuncture in clinical practice is unique and effective, and the human acupuncture points play a mysterious and special role, however there is no modern scientific understanding on human acupuncture points until today. For this reason, we attend to use complex network theory, one of the frontiers in the statistical physics, for describing the human acupuncture points and their connections. In the network nodes are defined as the acupuncture points, two nodes are connected by an edge when they are used for a medical treatment of a common disease. A disease is defined as an act. Some statistical properties have been obtained. The results certify that the degree distribution, act degree distribution, and the dependence of the clustering coefficient on both of them obey SPL distribution function, which show a function interpolating between a power law and an exponential decay. The results may be helpful for understanding Chinese medical theory.

  19. An Empirical Study about China: Gender Equity in Science Education.

    ERIC Educational Resources Information Center

    Wang, Jianjun; Staver, John R.

    A data base representing a random sample of more than 10,000 grade 9 students in an SISS (Second IEA Science Study) Extended Study (SES), a key project supported by the China State Commission of Education in the late 1980s, was employed in this study to investigate gender equity in student science achievement in China. This empirical data analysis…

  20. Writing via Reading Software: An Empirical Study.

    ERIC Educational Resources Information Center

    Spillman, Carolyn V.; And Others

    A study evaluated the effects of one reading software program on the written language production of kindergarten and first grade students. Subjects were approximately 600 students from six different schools--three using the computerized reading program, Writing to Read, and three comparable in demographics, but not using the program. Stories…

  1. Instruction for Web Searching: An Empirical Study.

    ERIC Educational Resources Information Center

    Colaric, Susan M.

    2003-01-01

    Discussion of problems that users have with Web searching focuses on a study of undergraduates that investigated three instructional methods (instruction by example, conceptual models without illustrations, and conceptual models with illustrations) to determine differences in knowledge acquisition related to three types of knowledge (declarative,…

  2. Visual Design Principles: An Empirical Study of Design Lore

    ERIC Educational Resources Information Center

    Kimball, Miles A.

    2013-01-01

    Many books, designers, and design educators talk about visual design principles such as balance, contrast, and alignment, but with little consistency. This study uses empirical methods to explore the lore surrounding design principles. The study took the form of two stages: a quantitative literature review to determine what design principles are…

  3. Susceptibility of clinical Moraxella catarrhalis isolates in British Columbia to six empirically prescribed antibiotic agents

    PubMed Central

    Bandet, Tamara; Whitehead, Sue; Blondel-Hill, Edith; Wagner, Ken; Cheeptham, Naowarat

    2014-01-01

    BACKGROUND: Moraxella catarrhalis is a commensal organism of the respiratory tract that has emerged as an important pathogen for a variety of upper and lower respiratory tract infections including otitis media and acute exacerbations of chronic bronchitis. Susceptibility testing of M catarrhalis is not routinely performed in most diagnostic laboratories; rather, a comment predicting susceptibility based on the literature is attached to the report. The most recent Canadian report on M catarrhalis antimicrobial susceptibility was published in 2003; therefore, a new study at this time was of interest and importance. OBJECTIVE: To determine the susceptibility of M catarrhalis isolates from British Columbia to amoxicillin-clavulanate, doxycycline, clarithromycin, cefuroxime, levofloxacin and trimethoprimsulfamethoxazole. METHODS: A total of 117 clinical M catarrhalis isolates were isolated and tested from five Interior hospitals and two private laboratory centres in British Columbia between January and December 2012. Antibiotic susceptibility of M catarrhalis isolates was characterized using the Etest (E-strip; bioMérieux, USA) according to Clinical Laboratory Standards Institute guidelines. RESULTS: All isolates were sensitive to amoxicillin-clavulanate, doxycycline, clarithromycin, levofloxacin and trimethoprimsulfamethoxazole. One isolate was intermediately resistant to cefuroxime, representing a 99.15% sensitivity rate to the cephem agent. Cefuroxime minimum inhibitory concentrations (MICs) inhibiting 50% and 90% of organisms (MIC50 and MIC90) were highest among the antibiotics tested, and the MIC90 (3 μg/mL) of cefuroxime reached the Clinical Laboratory Standards Institute breakpoint of susceptibility. DISCUSSION: The antibiotic susceptibility of M catarrhalis isolates evaluated in the present study largely confirms the findings of previous surveillance studies performed in Canada. Cefuroxime MICs are in the high end of the sensitive range and the MIC50 and MIC90

  4. An empirical and model study on automobile market in Taiwan

    NASA Astrophysics Data System (ADS)

    Tang, Ji-Ying; Qiu, Rong; Zhou, Yueping; He, Da-Ren

    2006-03-01

    We have done an empirical investigation on automobile market in Taiwan including the development of the possession rate of the companies in the market from 1979 to 2003, the development of the largest possession rate, and so on. A dynamic model for describing the competition between the companies is suggested based on the empirical study. In the model each company is given a long-term competition factor (such as technology, capital and scale) and a short-term competition factor (such as management, service and advertisement). Then the companies play games in order to obtain more possession rate in the market under certain rules. Numerical simulation based on the model display a competition developing process, which qualitatively and quantitatively agree with our empirical investigation results.

  5. Educational Inequality and Income Inequality: An Empirical Study on China

    ERIC Educational Resources Information Center

    Yang, Jun; Huang, Xiao; Li, Xiaoyu

    2009-01-01

    Based on the endogenous growth theory, this paper uses the Gini coefficient to measure educational inequality and studies the empirical relationship between educational inequality and income inequality through a simultaneous equation model. The results show that: (1) Income inequality leads to educational inequality while the reduction of…

  6. An Empirical Study of Students on Academic Probation

    ERIC Educational Resources Information Center

    James, Cindy L.; Graham, Sarah

    2010-01-01

    A substantial number of university students are placed on academic probation each year, many of whom never succeed in academia. Hence, it is critical to identify who these students are, why they end up on academic probation, and most importantly how best to intervene. To determine this, an empirical study of students on academic probation for the…

  7. Continued Use of a Chinese Online Portal: An Empirical Study

    ERIC Educational Resources Information Center

    Shih, Hung-Pin

    2008-01-01

    The evolution of the internet has made online portals a popular means of surfing the internet. In internet commerce, understanding the post-adoption behaviour of users of online portals can help enterprises to attract new users and retain existing customers. For predicting continued use intentions, this empirical study focused on applying and…

  8. Threat, Intimidation, and Student Financial Market Knowledge: An Empirical Study

    ERIC Educational Resources Information Center

    Ford, Matthew W.; Devoto, Steve; Kent, Daniel W.; Harrison, Todd

    2007-01-01

    Threat emanating from financial markets may intimidate college students to some degree. In this article, the authors considered the influence of such intimidation on student financial market knowledge. They hypothesized a negative relationship between intimidation and market knowledge. An empirical study of over 150 undergraduate business school…

  9. Empirical Performance of Covariates in Education Observational Studies

    ERIC Educational Resources Information Center

    Wong, Vivian C.; Valentine, Jeffrey C.; Miller-Bains, Kate

    2017-01-01

    This article summarizes results from 12 empirical evaluations of observational methods in education contexts. We look at the performance of three common covariate-types in observational studies where the outcome is a standardized reading or math test. They are: pretest measures, local geographic matching, and rich covariate sets with a strong…

  10. Validity of Empirical Studies of Information System Effectiveness

    DTIC Science & Technology

    1989-06-01

    research design using the Campbell and Stanley (1966) taxonomy. 29 2. Handling Threats to Internal Validity Once a study was classified according to...randomized comparison groups, controls for all threats to internal validity. The difficult with the MIS empirical studies of effectiveness is that only four...a much sounder design that the one-group. Regrettably, only 2% of the reviewed studies employed a time-series design. B. HANDLING THREATS TO INTERNAL

  11. CLINICAL FEATURES AND OUTCOME OF INFECTIVE ENDOCARDITIS IN YEMENI PATIENTS TREATED WITH EMPIRICAL ANTIBIOTIC THERAPY

    PubMed Central

    Khaled, Al-Aghbari; Al-Noami, Alezzy Yahya; Al-Ansi, Mohamed; Faiza, Ahmed Askar

    2010-01-01

    Background: Infective endocarditis is a common disease in Yemen. Although the incidence of rheumatic valvular disease and uncorrected congenital heart disease in adults is high in Yemen, there are few data regarding the pattern, characteristic features and outcome of infective endocarditis in Yemen. Objective: The aim was to study the characteristic, clinical features and diagnostic criteria of infective endocarditis in Yemeni patients and the outcome in patients treated with medical therapy. Patients and Method: Seventy-two consecutive patients admitted to Kuwait teaching hospital in Sana’a with suspected infective endocarditis between June 1, 2005 and June 1, 2007 were included in this study. A questionnaire including history, clinical findings, and result of requested investigations, treatment, complications and outcome was used. The diagnosis was based on Dukes criteria, which proposed two major or five minor criteria. In our study, we included raised erythrocyte sedimentation rate (ESR) as a minor criteria. The patients were classified as definite, possible and rejected cases. All patients received empirical antibiotic therapy. Results: The mean age was 28.56 ± 14.5 years. Men were 30 (42.2%) while women were 42 (57.7%). 59 (81.9%) of the patients had been admitted due to fever. Past history of rheumatic heart disease was positive in 38 (53.3%) of the patients. Mitral regurgitation was the commonest form of valvular affection 54 (82.1%) of patients followed by aortic regurgitation in 45 (63%). Anemia was present in 53 (74%) while raised erythrocyte sedimentation rate was high in all patients. Vegetations were detected by transthorasic echocardiography in 51 (70.83%) of the patients while blood culture was positive in only 7 (9.6%). After adding high ESR to the criteria, definite infective endocarditis were found in 34 (47.2%); possible in 38 (52.7%) and no rejected patients. Sixty-two (87.5%) of the patients improved and were discharged in good general

  12. Reexamining competitive priorities: Empirical study in service sector

    NASA Astrophysics Data System (ADS)

    Idris, Fazli; Mohammad, Jihad

    2015-02-01

    The general objective of this study is to validate the multi-level concept of competitive priorities using reflective-formative model at a higher order for service industries. An empirical study of 228 firms from 9 different service industries is conducted to answer the objective of this study. Partial least square analysis with SmartPLS 2.0 was used to perform the analysis. Finding revealed six priorities: cost, flexibility, delivery, quality talent management, quality tangibility, and innovativeness. It emerges that quality are expanded into two types; one is related to managing talent for process improvement and the second one is the physical appearance and tangibility of the service quality. This study has confirmed competitive priorities as formative second-order hierarchical latent construct by using rigorous empirical evidence. Implications, limitation and suggestion for future research are accordingly discussed in this paper.

  13. Mission Operations Planning with Preferences: An Empirical Study

    NASA Technical Reports Server (NTRS)

    Bresina, John L.; Khatib, Lina; McGann, Conor

    2006-01-01

    This paper presents an empirical study of some nonexhaustive approaches to optimizing preferences within the context of constraint-based, mixed-initiative planning for mission operations. This work is motivated by the experience of deploying and operating the MAPGEN (Mixed-initiative Activity Plan GENerator) system for the Mars Exploration Rover Mission. Responsiveness to the user is one of the important requirements for MAPGEN, hence, the additional computation time needed to optimize preferences must be kept within reasonabble bounds. This was the primary motivation for studying non-exhaustive optimization approaches. The specific goals of rhe empirical study are to assess the impact on solution quality of two greedy heuristics used in MAPGEN and to assess the improvement gained by applying a linear programming optimization technique to the final solution.

  14. Model and empirical study on some collaboration networks

    NASA Astrophysics Data System (ADS)

    Zhang, Pei-Pei; Kan Chen; He, Yue; Zhou, Tao; Su, Bei-Bei; Jin, Yingdi; Chang, Hui; Zhou, Yue-Ping; Sun, Li-Cheng; Wang, Bing-Hong; He, Da-Ren

    2006-02-01

    In this paper we present an empirical study of a few practical systems described by cooperation networks, and propose a model to understand the results obtained. We study four non-social systems, which are the Bus Route Networks of Beijing and Yangzhou, the Travel Route Network of China, Huai-Yang recipes of Chinese cooked food, and a social system, which is the Collaboration Network of Hollywood Actors. In order to explain the results related to the degree distribution, act-degree distribution and act-size distribution (especially about the degree distribution, which may be better fitted using a stretched exponential distribution (SED)), we suggest a simple model to show a possible evolutionary mechanism for the emergence of such networks. The analytic and numerical results obtained from the model are in good agreement with the empirical results.

  15. Empirical study on clique-degree distribution of networks.

    PubMed

    Xiao, Wei-Ke; Ren, Jie; Qi, Feng; Song, Zhi-Wei; Zhu, Meng-Xiao; Yang, Hong-Feng; Jin, Hui-Yu; Wang, Bing-Hong; Zhou, Tao

    2007-09-01

    The community structure and motif-modular-network hierarchy are of great importance for understanding the relationship between structures and functions. We investigate the distribution of clique degrees, which are an extension of degree and can be used to measure the density of cliques in networks. Empirical studies indicate the extensive existence of power-law clique-degree distributions in various real networks, and the power-law exponent decreases with an increase of clique size.

  16. An Empirical Bayes Method for Multivariate Meta-analysis with an Application in Clinical Trials

    PubMed Central

    Chen, Yong; Luo, Sheng; Chu, Haitao; Su, Xiao; Nie, Lei

    2013-01-01

    We propose an empirical Bayes method for evaluating overall and study-specific treatment effects in multivariate meta-analysis with binary outcome. Instead of modeling transformed proportions or risks via commonly used multivariate general or generalized linear models, we directly model the risks without any transformation. The exact posterior distribution of the study-specific relative risk is derived. The hyperparameters in the posterior distribution can be inferred through an empirical Bayes procedure. As our method does not rely on the choice of transformation, it provides a flexible alternative to the existing methods and in addition, the correlation parameter can be intuitively interpreted as the correlation coefficient between risks. PMID:25089070

  17. Assessment and treatment of PTSD after a motor vehicle collision: Empirical findings and clinical observations

    PubMed Central

    Beck, J. Gayle; Coffey, Scott F.

    2007-01-01

    Individuals who experience a serious motor vehicle accident (MVA) are at increased risk for psychological problems, particularly Posttraumatic Stress Disorder (PTSD). In this article, we review the literature on PTSD among MVA survivors, with particular attention to available instruments to screen for and assess symptomatology of the disorder. Approaches to the treatment of PTSD in this population are reviewed, separated into interventions designed to prevent PTSD in unselected samples, treatment targeting individuals with Acute Stress Disorder that are designed to prevent subsequent development of PTSD, and therapy for individuals with chronic PTSD. Treatment process issues are discussed, in an effort to integrate empirical findings with clinical observations. The empirical literature suggests several approaches to treatment that have good potential outcomes, although continued work is needed to identify factors that predict treatment response, as well as augment individual-based treatment formats. PMID:18509507

  18. Cancer support groups: a critical review of empirical studies.

    PubMed

    Gottlieb, Benjamin H; Wachala, Elizabeth D

    2007-05-01

    Support groups for adults affected by cancer are widely offered by local community and national agencies in North America. This type of psychosocial intervention is defined in terms of its structure and functions, and its theoretical underpinnings and models of practice are described. Forty-four empirical studies of professionally led cancer support groups are summarized and critically reviewed. These studies include 32 outcome evaluations of randomized controlled trials, two process evaluations, and 10 consumer satisfaction studies. The findings reveal high levels of consumer satisfaction, and the outcome evaluations substantiate the morale and other quality of life benefits short of prolonging life. Discussion centers on priorities for future research and practice.

  19. Empirical studies of design software: Implications for software engineering environments

    NASA Technical Reports Server (NTRS)

    Krasner, Herb

    1988-01-01

    The empirical studies team of MCC's Design Process Group conducted three studies in 1986-87 in order to gather data on professionals designing software systems in a range of situations. The first study (the Lift Experiment) used thinking aloud protocols in a controlled laboratory setting to study the cognitive processes of individual designers. The second study (the Object Server Project) involved the observation, videotaping, and data collection of a design team of a medium-sized development project over several months in order to study team dynamics. The third study (the Field Study) involved interviews with the personnel from 19 large development projects in the MCC shareholders in order to study how the process of design is affected by organizationl and project behavior. The focus of this report will be on key observations of design process (at several levels) and their implications for the design of environments.

  20. Chaotic Visual Cryptosystem Using Empirical Mode Decomposition Algorithm for Clinical EEG Signals.

    PubMed

    Lin, Chin-Feng

    2016-03-01

    This paper, proposes a chaotic visual cryptosystem using an empirical mode decomposition (EMD) algorithm for clinical electroencephalography (EEG) signals. The basic design concept is to integrate two-dimensional (2D) chaos-based encryption scramblers, the EMD algorithm, and a 2D block interleaver method to achieve a robust and unpredictable visual encryption mechanism. Energy-intrinsic mode function (IMF) distribution features of the clinical EEG signal are developed for chaotic encryption parameters. The maximum and second maximum energy ratios of the IMFs of a clinical EEG signal to its refereed total energy are used for the starting points of chaotic logistic map types of encrypted chaotic signals in the x and y vectors, respectively. The minimum and second minimum energy ratios of the IMFs of a clinical EEG signal to its refereed total energy are used for the security level parameters of chaotic logistic map types of encrypted chaotic signals in the x and y vectors, respectively. Three EEG database, and seventeen clinical EEG signals were tested, and the average r and mse values are 0.0201 and 4.2626 × 10(-29), respectively, for the original and chaotically-encrypted through EMD clinical EEG signals. The chaotically-encrypted signal cannot be recovered if there is an error in the input parameters, for example, an initial point error of 0.000001 %. The encryption effects of the proposed chaotic EMD visual encryption mechanism are excellent.

  1. A Trade Study of Thermosphere Empirical Neutral Density Models

    DTIC Science & Technology

    2014-08-01

    OCP 8725 John J. Kingman Rd, Suite 0944 Ft Belvoir, VA 22060-6218 1 cy AFRL /RVIL Kirtland AFB, NM 87117-5776 2 cys Official Record Copy AFRL ... AFRL -RV-PS- TR-2016-0008 AFRL -RV-PS- TR-2016-0008 A TRADE STUDY OF THERMOSPHERE EMPIRICAL NEUTRAL DENSITY MODELS Chin S. Lin, et al. 1 August...Ave SE AIR FORCE MATERIEL COMMAND KIRTLAND AIR FORCE BASE, NM 87117-5776 DTIC COPY NOTICE AND SIGNATURE PAGE Using Government drawings

  2. Empirical orthogonal functions and normal modes. [for atmospheric data studies

    NASA Technical Reports Server (NTRS)

    North, G. R.

    1984-01-01

    An attempt to provide physical insight into the empirical orthogonal function (EOF) representation of data fields by the study of fields generated by linear stochastic models is presented in this paper. In a large class of these models, the EOFs at individual Fourier frequencies coincide with the orthogonal mechanical modes of the system - provided they exist. The precise mathematical criteria for this coincidence are derived and a physical interpretation is provided. A scheme possibly useful in forecasting is formally constructed for representing any stochastic field by a linear Hermitian model forced by noise.

  3. An empirical evaluation of multidimensional clinical outcome in chronic low back pain patients.

    PubMed

    Klapow, J C; Slater, M A; Patterson, T L; Doctor, J N; Atkinson, J H; Garfin, S R

    1993-10-01

    Individuals with persisting pain often present a constellation of symptoms that includes pain, health-related impairment and dysphoric mood. It is now widely accepted that comprehensive assessment must address each of these dimensions. Despite recognition of the value of multidimensional assessment, no empirical efforts have validated the construct of a multidimensional clinical outcome presentation based on the dimensions of pain, impairment and dysphoric mood. We employed cluster analytic procedures on standard measures of pain, impairment and depression in chronic low back pain (CLBP) patients (n = 96) attending a general orthopedic clinic in order to empirically characterize multidimensional clinical outcomes. Results indicated that 3 groups could be identified reliably: (1) 'Chronic Pain Syndrome' (n = 25; high levels of pain, impairment and depression), (2) 'Positive Adaptation to Pain' (n = 24; high levels of pain with low levels of impairment and depression) and (3) 'Good Pain Control' (n = 47; low levels of pain, impairment and depression). The reliability of this cluster solution was supported by several tests of internal consistency. Discriminability of the clusters was examined across both the outcome measures themselves and several additional independent variables. The cluster solution was then cross-validated in an independent sample of pain clinic CLBP patients (n = 180) to test its generalizability. Finally the stability of the cluster dimensions over time was tested by re-assessing 36 CLBP patients 6 months after they initially were characterized into 1 of the 3 outcome groups on the same measures. MANOVA results indicated that the outcome groups were differentiated statistically across assessments. The multiple outcome measures did not change significantly across time, nor did the outcome groups change differentially across time on these measures. We conclude that the outcome dimensions of pain, impairment and depression are relatively stable

  4. Environmental performance indicators: an empirical study of Canadian manufacturing firms.

    PubMed

    Henri, Jean-François; Journeault, Marc

    2008-04-01

    The aim of this exploratory study is to examine the importance of measurement and use of environmental performance indicators (EPIs) within manufacturing firms. Two research questions are investigated: (i) To what extent are firm characteristics associated with the importance of measurement of various categories of EPIs? (ii) To what extent are firm characteristics associated with global and specific uses of EPIs? More specifically, this paper examines four uses of EPIs (i.e. to monitor compliance, to motivate continuous improvement, to support decision making, and to provide data for external reporting) as well as four characteristics of firms, namely environmental strategy, International Organization for Standardization (ISO) 14001 compliance, size, and ownership. This study contributes to the environmental management accounting literature by collecting and analyzing empirical evidence that provides a better understanding of the associations among firm characteristics and EPIs.

  5. An empirical study of the DSM-IV Defensive Functioning Scale in personality disordered patients.

    PubMed

    Blais, M A; Conboy, C A; Wilcox, N; Norman, D K

    1996-01-01

    The inclusion of the Defensive Functioning Scale (DFS) in the DSM-IV provides clinicians with the opportunity to incorporate psychodynamic information into their descriptive diagnoses. The DFS contains 27 specific defenses covering six levels of defensive functioning ranging from psychotic to normal. This study undertook an initial empirical evaluation of the DFS. A sample of 100 clinicians completed a questionnaire containing both the personality disorder (PD) symptoms and the DFS defenses of PD patients known to them, DFS ratings were not related to clinician orientation. Patient gender was related to only one defense level, with women being assigned significantly more action level defenses than men. Multiple regression analyses revealed unique and meaningful patterns of association between the defense levels and PD symptoms. Additionally, the DFS ratings provided unique information regarding level of impairment and treatment success. These results provide initial empirical support for the clinical application and relevance of the proposed DFS system.

  6. Tomography by iterative convolution - Empirical study and application to interferometry

    NASA Technical Reports Server (NTRS)

    Vest, C. M.; Prikryl, I.

    1984-01-01

    An algorithm for computer tomography has been developed that is applicable to reconstruction from data having incomplete projections because an opaque object blocks some of the probing radiation as it passes through the object field. The algorithm is based on iteration between the object domain and the projection (Radon transform) domain. Reconstructions are computed during each iteration by the well-known convolution method. Although it is demonstrated that this algorithm does not converge, an empirically justified criterion for terminating the iteration when the most accurate estimate has been computed is presented. The algorithm has been studied by using it to reconstruct several different object fields with several different opaque regions. It also has been used to reconstruct aerodynamic density fields from interferometric data recorded in wind tunnel tests.

  7. Information Assurance in Saudi Organizations - An Empirical Study

    NASA Astrophysics Data System (ADS)

    Nabi, Syed Irfan; Mirza, Abdulrahman A.; Alghathbar, Khaled

    This paper presents selective results of a survey conducted to find out the much needed insight into the status of information security in Saudi Arabian organizations. The purpose of this research is to give the state of information assurance in the Kingdom and to better understand the prevalent ground realities. The survey covered technical aspects of information security, risk management and information assurance management. The results provide deep insights in to the existing level of information assurance in various sectors that can be helpful in better understanding the intricate details of the prevalent information security in the Kingdom. Also, the results can be very useful for information assurance policy makers in the government as well as private sector organizations. There are few empirical studies on information assurance governance available in literature, especially about the Middle East and Saudi Arabia, therefore, the results are invaluable for information security researchers in improving the understanding of information assurance in this region and the Kingdom.

  8. Empirical study of the tails of mutual fund size

    NASA Astrophysics Data System (ADS)

    Schwarzkopf, Yonathan; Farmer, J. Doyne

    2010-06-01

    The mutual fund industry manages about a quarter of the assets in the U.S. stock market and thus plays an important role in the U.S. economy. The question of how much control is concentrated in the hands of the largest players is best quantitatively discussed in terms of the tail behavior of the mutual fund size distribution. We study the distribution empirically and show that the tail is much better described by a log-normal than a power law, indicating less concentration than, for example, personal income. The results are highly statistically significant and are consistent across fifteen years. This contradicts a recent theory concerning the origin of the power law tails of the trading volume distribution. Based on the analysis in a companion paper, the log-normality is to be expected, and indicates that the distribution of mutual funds remains perpetually out of equilibrium.

  9. Differential Weighting: A Survey of Methods and Empirical Studies.

    ERIC Educational Resources Information Center

    Stanley, Julian C.; Wang, Marilyn D.

    The literature on a priori and empirical weighting of test items and test-item options is reviewed. While multiple regression is the best known technique for deriving fixed empirical weights for component variables (such as tests and test items), other methods allow one to derive weights which equalize the effective weights of the component…

  10. An Empirical Study of Student Willingness to Study Abroad

    ERIC Educational Resources Information Center

    Hackney, Kaylee; Boggs, David; Borozan, Anci

    2012-01-01

    Companies wish for universities to provide business students with international education and awareness. Short- and long-term study-abroad programs are an effective method by which this is accomplished, but relatively few American students study abroad. In response to these facts, this study develops hypotheses that predict student willingness to…

  11. Communication and Organization in Software Development: An Empirical Study

    NASA Technical Reports Server (NTRS)

    Seaman, Carolyn B.; Basili, Victor R.

    1996-01-01

    The empirical study described in this paper addresses the issue of communication among members of a software development organization. The independent variables are various attributes of organizational structure. The dependent variable is the effort spent on sharing information which is required by the software development process in use. The research questions upon which the study is based ask whether or not these attributes of organizational structure have an effect on the amount of communication effort expended. In addition, there are a number of blocking variables which have been identified. These are used to account for factors other than organizational structure which may have an effect on communication effort. The study uses both quantitative and qualitative methods for data collection and analysis. These methods include participant observation, structured interviews, and graphical data presentation. The results of this study indicate that several attributes of organizational structure do affect communication effort, but not in a simple, straightforward way. In particular, the distances between communicators in the reporting structure of the organization, as well as in the physical layout of offices, affects how quickly they can share needed information, especially during meetings. These results provide a better understanding of how organizational structure helps or hinders communication in software development.

  12. Data envelopment analysis in service quality evaluation: an empirical study

    NASA Astrophysics Data System (ADS)

    Najafi, Seyedvahid; Saati, Saber; Tavana, Madjid

    2015-10-01

    Service quality is often conceptualized as the comparison between service expectations and the actual performance perceptions. It enhances customer satisfaction, decreases customer defection, and promotes customer loyalty. Substantial literature has examined the concept of service quality, its dimensions, and measurement methods. We introduce the perceived service quality index (PSQI) as a single measure for evaluating the multiple-item service quality construct based on the SERVQUAL model. A slack-based measure (SBM) of efficiency with constant inputs is used to calculate the PSQI. In addition, a non-linear programming model based on the SBM is proposed to delineate an improvement guideline and improve service quality. An empirical study is conducted to assess the applicability of the method proposed in this study. A large number of studies have used DEA as a benchmarking tool to measure service quality. These models do not propose a coherent performance evaluation construct and consequently fail to deliver improvement guidelines for improving service quality. The DEA models proposed in this study are designed to evaluate and improve service quality within a comprehensive framework and without any dependency on external data.

  13. The pragmatics of therapeutic interaction: an empirical study.

    PubMed

    Lepper, Georgia

    2009-10-01

    The research reported in this article aims to demonstrate a method for the systematic study of the therapist/patient interaction in psychoanalytic psychotherapy, drawing upon the tradition and methods of 'pragmatics'--the study of language in interaction. A brief introduction to the discipline of pragmatics demonstrates its relevance to the contemporary focus of clinical theory on the here-and-now dynamics of the relationship between analyst and patient. This is followed by a detailed study of five segments from the transcript of a therapeutic dialogue, drawn from a brief psychoanalytic psychotherapy, in which therapist and patient negotiate the meaning of the patient's symptom: Is it psychosomatic? The research seeks to show how the therapeutic process can be observed and studied as an interactional achievement, grounded in general and well-studied procedures through which meaning is intersubjectively developed and shared. Implications of the analysis for clinical theory and practice, and further research, are discussed.

  14. Adult Attachment and Developmental Personality Styles: An Empirical Study

    ERIC Educational Resources Information Center

    Sherry, Alissa; Lyddon, William J.; Henson, Robin K.

    2007-01-01

    The current study was designed to test specific hypotheses associated with W. J. Lyddon and A. Sherry's (2001) attachment theory model of developmental personality styles. More specifically, 4 adult attachment dimensions were correlated with 10 personality scales on the Millon Clinical Multiaxial Inventory-III (T. Millon, R. Davis, & C.…

  15. Physician leadership styles and effectiveness: an empirical study.

    PubMed

    Xirasagar, Sudha; Samuels, Michael E; Stoskopf, Carleen H

    2005-12-01

    The authors study the association between physician leadership styles and leadership effectiveness. Executive directors of community health centers were surveyed (269 respondents; response rate = 40.9 percent) for their perceptions of the medical director's leadership behaviors and effectiveness, using an adapted Multifactor Leadership Questionnaire (43 items on a 0-4 point Likert-type scale), with additional questions on demographics and the center's clinical goals and achievements. The authors hypothesize that transformational leadership would be more positively associated with executive directors' ratings of effectiveness, satisfaction with the leader, and subordinate extra effort, as well as the center's clinical goal achievement, than transactional or laissez-faire leadership. Separate ordinary least squares regressions were used to model each of the effectiveness measures, and general linear model regression was used to model clinical goal achievement. Results support the hypothesis and suggest that physician leadership development using the transformational leadership model may result in improved health care quality and cost control.

  16. Psychological Vulnerability to Completed Suicide: A Review of Empirical Studies.

    ERIC Educational Resources Information Center

    Conner, Kenneth R.; Duberstein, Paul R.; Conwell, Yeates; Seidlitz, Larry; Caine, Eric D.

    2001-01-01

    This article reviews empirical literature on psychological vulnerability to completed suicide. Five constructs have been consistently associated with completed suicide: impulsivity/aggression; depression; anxiety; hopelessness; and self-consciousness/social disengagement. Current knowledge of psychological vulnerability could inform social…

  17. An efficient empirical Bayes method for genomewide association studies.

    PubMed

    Wang, Q; Wei, J; Pan, Y; Xu, S

    2016-08-01

    Linear mixed model (LMM) is one of the most popular methods for genomewide association studies (GWAS). Numerous forms of LMM have been developed; however, there are two major issues in GWAS that have not been fully addressed before. The two issues are (i) the genomic background noise and (ii) low statistical power after Bonferroni correction. We proposed an empirical Bayes (EB) method by assigning each marker effect a normal prior distribution, resulting in shrinkage estimates of marker effects. We found that such a shrinkage approach can selectively shrink marker effects and reduce the noise level to zero for majority of non-associated markers. In the meantime, the EB method allows us to use an 'effective number of tests' to perform Bonferroni correction for multiple tests. Simulation studies for both human and pig data showed that EB method can significantly increase statistical power compared with the widely used exact GWAS methods, such as GEMMA and FaST-LMM-Select. Real data analyses in human breast cancer identified improved detection signals for markers previously known to be associated with breast cancer. We therefore believe that EB method is a valuable tool for identifying the genetic basis of complex traits.

  18. Empirical approaches to the study of language evolution.

    PubMed

    Fitch, W Tecumseh

    2017-02-01

    The study of language evolution, and human cognitive evolution more generally, has often been ridiculed as unscientific, but in fact it differs little from many other disciplines that investigate past events, such as geology or cosmology. Well-crafted models of language evolution make numerous testable hypotheses, and if the principles of strong inference (simultaneous testing of multiple plausible hypotheses) are adopted, there is an increasing amount of relevant data allowing empirical evaluation of such models. The articles in this special issue provide a concise overview of current models of language evolution, emphasizing the testable predictions that they make, along with overviews of the many sources of data available to test them (emphasizing comparative, neural, and genetic data). The key challenge facing the study of language evolution is not a lack of data, but rather a weak commitment to hypothesis-testing approaches and strong inference, exacerbated by the broad and highly interdisciplinary nature of the relevant data. This introduction offers an overview of the field, and a summary of what needed to evolve to provide our species with language-ready brains. It then briefly discusses different contemporary models of language evolution, followed by an overview of different sources of data to test these models. I conclude with my own multistage model of how different components of language could have evolved.

  19. An empirical study of FORTRAN programs for parallelizing compilers

    NASA Technical Reports Server (NTRS)

    Shen, Zhiyu; Li, Zhiyuan; Yew, Pen-Chung

    1990-01-01

    Some results are reported from an empirical study of program characteristics that are important in parallelizing compiler writers, especially in the area of data dependence analysis and program transformations. The state of the art in data dependence analysis and some parallel execution techniques are examined. The major findings are included. Many subscripts contain symbolic terms with unknown values. A few methods of determining their values at compile time are evaluated. Array references with coupled subscripts appear quite frequently; these subscripts must be handled simultaneously in a dependence test, rather than being handled separately as in current test algorithms. Nonzero coefficients of loop indexes in most subscripts are found to be simple: they are either 1 or -1. This allows an exact real-valued test to be as accurate as an exact integer-valued test for one-dimensional or two-dimensional arrays. Dependencies with uncertain distance are found to be rather common, and one of the main reasons is the frequent appearance of symbolic terms with unknown values.

  20. A comparative study between Empirical Wavelet Transforms and Empirical Mode Decomposition Methods: Application to bearing defect diagnosis

    NASA Astrophysics Data System (ADS)

    Kedadouche, M.; Thomas, M.; Tahan, A.

    2016-12-01

    The Ensemble Empirical Mode Decomposition (EEMD) is a noise assisted method that may sometimes provide a significant improvement on Empirical Mode Decomposition (EMD). However, the amplitude and number of added noise need to be selected when applying the EEMD method. Furthermore, the computation time which depends on the number of ensemble trails is very high compared to the EMD. In this paper, a new way for choosing the appropriate added noise is presented. Conversely, a recently-developed method called the Empirical Wavelet Transform (EWT) is investigated. A comparative study between the EMD and EWT methods is conducted. The results show that the EWT is better than the EEMD and EMD on mode estimates and computation time is significantly reduced. An experimental study on bearing diagnosis is conducted. The EWT is applied to experimental data coming from damaged bearings. In the paper, an index selection is introduced that allows for the automatic selection of the Intrinsic Mode Functions (IMF) that should be used to perform the envelope spectrum. It is shown that choosing all the IMF selected by the index is more efficient than only choosing the best one. The envelope of the sum of the selected IMF clearly reveals the bearing frequencies and its harmonics which are excited by the defect. This approach seems to be an effective and efficient method for processing bearing fault signals.

  1. Flood risk changes over centuries in Rome: an empirical study

    NASA Astrophysics Data System (ADS)

    Di Baldassarre, Giuliano; Saccà, Smeralda; Tito Aronica, Giuseppe; Grimaldi, Salvatore; Crisci, Massimiliano

    2015-04-01

    Over centuries, the development of the historical city of Rome -close to one of the largest Italian rivers, the Tiber- has been intertwined with the magnitude and frequency of flooding events. The ancient Rome mostly developed on the (seven) hills, while the Tiber's floodplain was mainly exploited for agricultural purposes. A few small communities did settle in the riparian areas of the Tiber, but they had a relatively peaceful relationships with the frequent occurrence of flooding events. Nowadays, numerous people live in modern districts in the Tiber's floodplain, unaware of their exposure to potentially catastrophic flooding. The main goal of this research is to explore the dynamics of changing flood risk over the centuries between these two extreme pictures of the ancient and contemporary Rome. To this end, we carried out a socio-hydrological study by exploiting long time series of physical (flooding, river morphology) and social (urbanization, population dynamics) processes together with information about human interactions with the environment (flood defense structures). This empirical analysis showed how human and physical systems have been co-evolving over time, while being abruptly altered by the occurrence of extreme events. For instance, a large flooding event occurred in 1870 and contributed to the constructions of levees, which in turn facilitated the development of new urban areas in the Tiber's floodplain, while changed the societal memory of floods as well as the communities' perception of risk. This research work was also used to test the hypotheses of recent-developed models conceptualizing the interplay between floods and societies and simulating the long-term behavior of coupled human-water systems. The outcomes of this test provided interesting insights about the dynamics of flood risk, which are expected to support a better anticipation of future changes.

  2. Empirical Study of Formative Evaluation in Adult ESL Teaching

    ERIC Educational Resources Information Center

    Yi, Qin

    2012-01-01

    Formative Evaluation is a method of evaluating a program while the program activities are forming or happening. Formative evaluation focuses on the "process" during which problems are timely spotted, corrected and adjustments made so that an intended goal can be accomplished. Through a four-month empirical research work with students of…

  3. Clinical Studies with Epothilones

    NASA Astrophysics Data System (ADS)

    Altmann, Karl-Heinz

    As indicated in previous chapters, epothilone research so far has delivered seven new chemical entities that have been advanced to clinical trials in humans (Fig. 1). However, the amount of clinical data publicly available at this time strongly varies between individual compounds, depending on their development stage, but also on the general publication policy of the developing company. The compound that has been most comprehensively characterized in the clinical literature is ixabepilone (BMS-247550), for which trial results have been described in a number of articles in peer-reviewed journals and which has been granted FDA approval for two clinical indications on Oct. 16, 2007. For all other compounds, most of the information on clinical trials is available only in abstract form. In all these cases it remains uncertain, whether the content of these abstracts fully reflects the content of the subsequent (poster or oral) presentations at the corresponding meeting; in fact, it seems likely that additional data will have been included in the actual meeting presentations that may not have been available at the time of abstract submission. As this is unknown to the author, such additional information cannot be considered in this chapter, which is solely based on information documented in accessible abstracts or journal publications. It should also be kept in mind that the interpretation of data from ongoing clinical trials or forward looking statements based on data from completed trials are always preliminary in character.

  4. Empirical caspofungin therapy in clinical practice for suspected invasive fungal disease in adults with acute lymphoblastic leukaemia.

    PubMed

    Kiehl, Michael G; Egerer, Gerlinde; Engelhardt, Monika; Gross, Barbara

    2015-02-01

    Patients with acute lymphoblastic leukaemia (ALL) after cytotoxic chemotherapy or haematopoietic stem cell transplantation (HSCT) are at risk for life-threatening invasive fungal disease (IFD). The aim was to evaluate the characteristics, antifungal therapy and outcome of adult patients with ALL after chemotherapy or HSCT receiving caspofungin empirically in a clinical setting. Retrospective chart reviews were conducted at nine large tertiary care centres in Germany. Adult patients with ALL treated empirically with caspofungin according to the product label between 2006 and 2012 were eligible. Data were extracted as case reports. In total, 25 patients (12 males, 13 females; median age 37 years; 19 with B-ALL, 6 with T-ALL) with 28 treatment episodes because of suspected IFD (18 episodes after chemotherapy, 10 episodes after allogeneic HSCT) were included in the analysis. Empirical caspofungin therapy (median duration: 19 days, range 1-105 days) was given as first-line monotherapy in 20 (71.4%), second-line monotherapy in five (17.9%) and combination therapy in three (10.7%) episodes respectively. Therapy rated successful according to the physician's overall assessment (inflammatory parameters, clinical symptoms): 20 (95%) of 21 evaluable episodes with therapy duration of at least 8 days. Empirical caspofungin appears to be an effective therapeutic option in critically ill adult ALL patients with suspected IFD in clinical practice.

  5. An Empirical Study on Operator Interface Design for Handheld Devices to Control Micro Aerial Vehicles

    DTIC Science & Technology

    2010-10-01

    An Empirical Study on Operator Interface Design for Handheld Devices to Control Micro Aerial Vehicles Ming Hou...Report DRDC Toronto TR 2010-075 October 2010 An Empirical Study on Operator Interface Design for Handheld Devices to...drives the need for a small and light controller which will not hinder a soldier carrying it. This requirement brings an issue of designing an

  6. The DSM classification of personality disorder: clinical wisdom or empirical truth? A response to Alvin R. Mahrer's problem 11.

    PubMed

    Klonsky, E D

    2000-12-01

    In a recent issue of the Journal of Clinical Psychology Alvin R. Mahrer (1999, pp. 1147-1156) outlined 11 problems facing the field of psychotherapy. Problem 11 states that psychotherapy rests on a foundation of truths that have not been tested in ways that could find them to be false. This point is especially pertinent to the DSM classification of personality disorders. None of the DSM-IV categories of personality disorder were discovered through empirical research. Rather, they were hypothesized by psychiatrists and psychologists, and put into writing. A review of the relevant literature reveals that empirical research findings rarely agree with the DSM conceptions of personality disorder classification. It is concluded that only through continuing empirical research efforts can we discover how nature "intended" personality pathology to be classified.

  7. Additive empirical parametrization and microscopic study of deuteron breakup

    NASA Astrophysics Data System (ADS)

    Avrigeanu, M.; Avrigeanu, V.

    2017-02-01

    Comparative assessment of the total breakup proton-emission cross sections measured for 56 MeV deuteron interaction with target nuclei from 12C to 209Bi, with an empirical parametrization and recently calculated microscopic neutron-removal cross sections was done at the same time with similar data measured at 15, 25.5, 70, and 80 MeV. Comparable mass dependencies of the elastic-breakup (EB) cross sections provided by the empirical parametrization and the microscopic results have been also found at the deuteron energy of 56 MeV, while the assessment of absolute-values variance up to a factor of two was not possible because of the lack of EB measurements at energies higher than 25.5 MeV. While the similarities represent an additional validation of the microscopic calculations, the cross-section difference should be considered within the objectives of further measurements.

  8. Children's living arrangements following separation and divorce: insights from empirical and clinical research.

    PubMed

    Kelly, Joan B

    2007-03-01

    When parents separate, children typically enter into new living arrangements with each parent in a pattern determined most often by one or both parents or, failing private agreement, as a result of recommendations and decisions by lawyers, therapists, custody evaluators, or family courts. Most of these decisions have been based on cultural traditions and beliefs regarding postseparation parenting plans, visitation guidelines adopted within jurisdictions, unsubstantiated theory, and strongly held personal values and professional opinions, and have resulted since the 1960s in children spending most of their time with one residential parent and limited time with nonresident, or "visiting", parents. A large body of social science and child development research generated over the past three decades has identified factors associated with risk and resiliency of children after divorce. Such research remains largely unknown and untapped by parents and professionals making these crucial decisions about children's living arrangements. This article highlights empirical and clinical research that is relevant to the shape of children's living arrangements after separation, focusing first on what is known about living arrangements following divorce, what factors influence living arrangements for separated and divorced children, children's views about their living arrangements, and living arrangements associated with children's adjustment following divorce. Based on this research, it is argued that traditional visiting patterns and guidelines are, for the majority of children, outdated, unnecessarily rigid, and restrictive, and fail in both the short and long term to address their best interests. Research-based parenting plan models offering multiple options for living arrangements following separation and divorce more appropriately serve children's diverse developmental and psychological needs.

  9. The Role of Light and Music in Gambling Behaviour: An Empirical Pilot Study

    ERIC Educational Resources Information Center

    Spenwyn, Jenny; Barrett, Doug J. K.; Griffiths, Mark D.

    2010-01-01

    Empirical research examining the situational characteristics of gambling and their effect on gambling behaviour is limited but growing. This experimental pilot investigation reports the first ever empirical study into the combined effects of both music and light on gambling behaviour. While playing an online version of roulette, 56 participants…

  10. An empirical study of opinion leader effects on mobile information technology adoption in healthcare.

    PubMed

    Hao, Haijing; Padman, Rema; Telang, Rahul

    2011-01-01

    Given the increasing number of applications but slow adoption of IT, including mobile IT, in healthcare, it is important to develop a better understanding of the contextual factors that motivate IT adoption by physicians. Although studies have shown that age or gender may affect physicians' IT adoption, those factors cannot be controlled when deploying a new IT. Therefore, the current research examines empirical evidence of a contextual factor, opinion leader effects, on IT adoption in healthcare that can be influenced by organizational policies. Using a unique panel dataset of physicians' usage of a mobile clinical IT from a community hospital, we observe a significant result that physicians under the influence of opinion leaders are three times more likely to adopt the IT than otherwise. This finding suggests that incentivizing a small proportion of opinion leaders to adopt a new IT has the potential to motivate wider adoption across the organization.

  11. Empirically supported treatments for panic disorder with agoraphobia in a Spanish psychology clinic.

    PubMed

    Ballesteros, Francisco; Labrador, Francisco J

    2014-10-27

    The aim of this work is to study the sociodemographic and clinical characteristics of patients diagnosed with Panic Disorder with Agoraphobia (PD/Ag), as well as the characteristics of the treatment and its results and cost in a University Psychology Clinic. Fifty patients demanded psychological assistance for PD/Ag; 80% were women, with an average age of 29.22 years (SD = 9.03). Mean number of evaluation sessions was 3.26 (SD = 1.03), and of treatment sessions, 13.39 (SD = 9.237). Of the patients, 83.33% were discharged (that is, questionnaire scores were below the cut-off point indicated by the authors, and no PD/Ag was observed at readministration of the semistructured interview), 5.5% refused treatment, and 11% were dropouts. The average number of treatment sessions of patients who achieved therapeutic success was 15.13 (SD = 8.98). Effect sizes (d) greater than 1 were obtained in all the scales. Changes in all scales were significant (p < .05). The estimated cost of treatment for patients who achieved therapeutic success was 945.12€. The treatment results are at least similar to those of studies of efficacy and effectiveness for PD/Ag. The utility of generalizing treatments developed in research settings to a welfare clinic is discussed.

  12. Children and Clinical Studies: Why Clinical Studies Are Important

    MedlinePlus Videos and Cool Tools

    ... Clinical Studies Children have often had to accept medicines and treatments based on what is known to ... children's health with the goal to develop treatments, drugs, and devices specific to children. Resources for a ...

  13. Learn about Clinical Studies

    MedlinePlus

    ... is to make sure that the study is ethical and that the rights and welfare of participants ... trials provide the basis for the development and marketing of new drugs, biological products, and medical devices. ...

  14. A multicenter phase 2 study of empirical low-dose liposomal amphotericin B in patients with refractory febrile neutropenia.

    PubMed

    Miyao, Kotaro; Sawa, Masashi; Kurata, Mio; Suzuki, Ritsuro; Sakemura, Reona; Sakai, Toshiyasu; Kato, Tomonori; Sahashi, Satomi; Tsushita, Natsuko; Ozawa, Yukiyasu; Tsuzuki, Motohiro; Kohno, Akio; Adachi, Tatsuya; Watanabe, Keisuke; Ohbayashi, Kaneyuki; Inagaki, Yuichiro; Atsuta, Yoshiko; Emi, Nobuhiko

    2017-01-01

    Invasive fungal infection (IFI) is a major life-threatening problem encountered by patients with hematological malignancies receiving intensive chemotherapy. Empirical antifungal agents are therefore important. Despite the availability of antifungal agents for such situations, the optimal agents and administration methods remain unclear. We conducted a prospective phase 2 study of empirical 1 mg/kg/day liposomal amphotericin B (L-AMB) in 80 patients receiving intensive chemotherapy for hematological malignancies. All enrolled patients were high-risk and had recurrent prolonged febrile neutropenia despite having received broad-spectrum antibacterial therapy for at least 72 hours. Fifty-three patients (66.3 %) achieved the primary endpoint of successful treatment, thus exceeding the predefined threshold success rate. No patients developed IFI. The treatment completion rate was 73.8 %, and only two cases ceased treatment because of adverse events. The most frequent events were reversible electrolyte abnormalities. We consider low-dose L-AMB to provide comparable efficacy and improved safety and cost-effectiveness when compared with other empirical antifungal therapies. Additional large-scale randomized studies are needed to determine the clinical usefulness of L-AMB relative to other empirical antifungal therapies.

  15. Success rate and risk factors for failure of empirical antifungal therapy with itraconazole in patients with hematological malignancies: a multicenter, prospective, open-label, observational study in Korea.

    PubMed

    Kim, Soo-Jeong; Cheong, June-Won; Min, Yoo Hong; Choi, Young Jin; Lee, Dong-Gun; Lee, Je-Hwan; Yang, Deok-Hwan; Lee, Sang Min; Kim, Sung-Hyun; Kim, Yang Soo; Kwak, Jae-Yong; Park, Jinny; Kim, Jin Young; Kim, Hoon-Gu; Kim, Byung Soo; Ryoo, Hun-Mo; Jang, Jun Ho; Kim, Min Kyoung; Kang, Hye Jin; Cho, In Sung; Mun, Yeung Chul; Jo, Deog-Yeon; Kim, Ho Young; Park, Byeong-Bae; Kim, Jin Seok

    2014-01-01

    We assessed the success rate of empirical antifungal therapy with itraconazole and evaluated risk factors for predicting the failure of empirical antifungal therapy. A multicenter, prospective, observational study was performed in patients with hematological malignancies who had neutropenic fever and received empirical antifungal therapy with itraconazole at 22 centers. A total of 391 patients who had abnormal findings on chest imaging tests (31.0%) or a positive result of enzyme immunoassay for serum galactomannan (17.6%) showed a 56.5% overall success rate. Positive galactomannan tests before the initiation of the empirical antifungal therapy (P=0.026, hazard ratio [HR], 2.28; 95% confidence interval [CI], 1.10-4.69) and abnormal findings on the chest imaging tests before initiation of the empirical antifungal therapy (P=0.022, HR, 2.03; 95% CI, 1.11-3.71) were significantly associated with poor outcomes for the empirical antifungal therapy. Eight patients (2.0%) had premature discontinuation of itraconazole therapy due to toxicity. It is suggested that positive galactomannan tests and abnormal findings on the chest imaging tests at the time of initiation of the empirical antifungal therapy are risk factors for predicting the failure of the empirical antifungal therapy with itraconazole. (Clinical Trial Registration on National Cancer Institute website, NCT01060462).

  16. Practical Implications of Empirically Studying Moral Decision-Making

    PubMed Central

    Heinzelmann, Nora; Ugazio, Giuseppe; Tobler, Philippe N.

    2012-01-01

    This paper considers the practical question of why people do not behave in the way they ought to behave. This question is a practical one, reaching both into the normative and descriptive domains of morality. That is, it concerns moral norms as well as empirical facts. We argue that two main problems usually keep us form acting and judging in a morally decent way: firstly, we make mistakes in moral reasoning. Secondly, even when we know how to act and judge, we still fail to meet the requirements due to personal weaknesses. This discussion naturally leads us to another question: can we narrow the gap between what people are morally required to do and what they actually do? We discuss findings from neuroscience, economics, and psychology, considering how we might bring our moral behavior better in line with moral theory. Potentially fruitful means include nudging, training, pharmacological enhancement, and brain stimulation. We conclude by raising the question of whether such methods could and should be implemented. PMID:22783157

  17. Understanding human queuing behaviour at exits: an empirical study

    PubMed Central

    Wagoum, A. U. Kemloh; Liao, W.

    2017-01-01

    The choice of the exit to egress from a facility plays a fundamental role in pedestrian modelling and simulation. Yet, empirical evidence for backing up simulation is scarce. In this contribution, we present three new groups of experiments that we conducted in different geometries. We varied parameters such as the width of the doors, the initial location and number of pedestrians which in turn affected their perception of the environment. We extracted and analysed relevant indicators such as distance to the exits and density levels. The results put in evidence the fact that pedestrians use time-dependent information to optimize their exit choice, and that, in congested states, a load balancing over the exits occurs. We propose a minimal modelling approach that covers those situations, especially the cases where the geometry does not show a symmetrical configuration. Most of the models try to achieve the load balancing by simulating the system and solving optimization problems. We show statistically and by simulation that a linear model based on the distance to the exits and the density levels around the exit can be an efficient dynamical alternative. PMID:28280588

  18. Do Special Occasions Trigger Psychological Distress Among Older Bereaved Spouses? An Empirical Assessment of Clinical Wisdom

    PubMed Central

    2014-01-01

    Objectives. Mental health professionals have suggested that widowed persons experience heightened psychological distress on dates that had special meaning for them and their late spouse, such as a wedding anniversary or the late spouse’s birthday. This study examined the effects of such occasions on grief, anxiety, and depressive symptoms in a community sample of older widowed persons. Methods. OLS regression models were estimated using data from the Changing Lives of Older Couples (CLOC) study, a large prospective probability study of late-life widowhood. Participants were interviewed prior to and both 6 and 18 months after spousal loss; married matched controls were interviewed at comparable times. Results. Widowed persons reported heightened psychological distress when interviewed during the month of their late spouse’s birthday, a post-holiday period (January), and in June, a month associated with wedding anniversaries and graduations in the United States. The distressing effects of special occasions on psychological symptoms were evidenced only within the first 6 months postloss, and were not apparent at the 18-month follow-up. Discussion. Our results support the clinical observation that persons in the early stages of spousal bereavement are at increased risk of psychological distress at times with special significance to the couple. We highlight methodological and clinical implications. PMID:23811691

  19. Empirical Derivation and Validation of a Clinical Case Definition for Neuropsychological Impairment in Children and Adolescents.

    PubMed

    Beauchamp, Miriam H; Brooks, Brian L; Barrowman, Nick; Aglipay, Mary; Keightley, Michelle; Anderson, Peter; Yeates, Keith O; Osmond, Martin H; Zemek, Roger

    2015-09-01

    Neuropsychological assessment aims to identify individual performance profiles in multiple domains of cognitive functioning; however, substantial variation exists in how deficits are defined and what cutoffs are used, and there is no universally accepted definition of neuropsychological impairment. The aim of this study was to derive and validate a clinical case definition rule to identify neuropsychological impairment in children and adolescents. An existing normative pediatric sample was used to calculate base rates of abnormal functioning on eight measures covering six domains of neuropsychological functioning. The dataset was analyzed by varying the range of cutoff levels [1, 1.5, and 2 standard deviations (SDs) below the mean] and number of indicators of impairment. The derived rule was evaluated by bootstrap, internal and external clinical validation (orthopedic and traumatic brain injury). Our neuropsychological impairment (NPI) rule was defined as "two or more test scores that fall 1.5 SDs below the mean." The rule identifies 5.1% of the total sample as impaired in the assessment battery and consistently targets between 3 and 7% of the population as impaired even when age, domains, and number of tests are varied. The NPI rate increases in groups known to exhibit cognitive deficits. The NPI rule provides a psychometrically derived method for interpreting performance across multiple tests and may be used in children 6-18 years. The rule may be useful to clinicians and scientists who wish to establish whether specific individuals or clinical populations present within expected norms versus impaired function across a battery of neuropsychological tests.

  20. Impact of source data verification on data quality in clinical trials: an empirical post hoc analysis of three phase 3 randomized clinical trials

    PubMed Central

    Andersen, Jeppe Ragnar; Byrjalsen, Inger; Bihlet, Asger; Kalakou, Faidra; Hoeck, Hans Christian; Hansen, Gitte; Hansen, Henrik Bo; Karsdal, Morten Asser; Riis, Bente Juel

    2015-01-01

    AIM The aim of this project was to perform an empirical evaluation of the impact of on site source data verification (SDV) on the data quality in a clinical trial database to guide an informed decision on selection of the monitoring approach. METHODS We used data from three randomized phase III trials monitored with a combination of complete SDV or partial SDV. After database lock, individual subject data were extracted from the clinical database and subjected to post hoc complete SDV. Error rates were calculated with focus on the degree of on study monitoring and relevance and analyzed for potential impact on end points. RESULTS Data from a total of 2566 subjects including more than 3 million data fields were 100% source data verified post hoc. An overall error rate of 0.45% was found. No sites had 0% errors. 100% SDV yielded an error rate of 0.27% as compared with partial SDV having an error rate of 0.53% (P < 0.0001). Comparing partly and fully monitored subjects, minor differences were identified between variables of major importance to efficacy or safety. CONCLUSIONS The findings challenge the notion that a 0% error rate is obtainable with on site monitoring. Data indicate consistently low error rates across the three trials analyzed. The use of complete vs. partial SDV offers a marginal absolute error rate reduction of 0.26%, i.e. a need to perform complete SDV of about 370 data points to avoid one unspecified error and does not support complete SDV as a means of providing meaningful improvements in data accuracy. PMID:25327707

  1. Experimental studies: randomized clinical trials.

    PubMed

    Gjorgov, A N

    1998-01-01

    There are two major approaches to medical investigations: observational studies and experimental trials. The classical application of the experimental design to studies of human populations is the randomized clinical trial of the efficacy of a new drug or treatment. A further application of the experimental studies is to the testing of hypotheses about the etiology of a disease, already tested and corroborated from various forms of observational studies. Ethical considerations and requirements for consent of the experimental subjects are of primary concern in the clinical trials, and those concerns set the first and final limits for implementing a trial. General moral principles in research with human and animal beings, defined by the "Nuremberg Code," deal with strict criteria for approval, endorsement and evaluation of a clinical trial.

  2. Empirical studies of software design: Implications for SSEs

    NASA Technical Reports Server (NTRS)

    Krasner, Herb

    1988-01-01

    Implications for Software Engineering Environments (SEEs) are presented in viewgraph format for characteristics of projects studied; significant problems and crucial problem areas in software design for large systems; layered behavioral model of software processes; implications of field study results; software project as an ecological system; results of the LIFT study; information model of design exploration; software design strategies; results of the team design study; and a list of publications.

  3. An Empirical Review of Internet Addiction Outcome Studies in China

    ERIC Educational Resources Information Center

    Liu, Chennan; Liao, Minli; Smith, Douglas C.

    2012-01-01

    Objectives: The authors systematically reviewed the outcomes and methodological quality of 24 Internet addiction (IA) treatment outcome studies in China. Method: The authors used 15 attributes from the quality of evidence scores to evaluate 24 outcome studies. These studies came from both English and Chinese academic databases from 2000 to 2010.…

  4. How Culture Affects Female Inequality across Countries: An Empirical Study

    ERIC Educational Resources Information Center

    Cheung, Hoi Yan; Chan, Alex W. H.

    2007-01-01

    Many studies have commented that culture has an influence on gender inequality. However, few studies have provided data that could be used to investigate how culture actually influences female inequality. One of the aims of this study is to investigate whether Hofstede's cultural dimensions have an impact on female inequality in education in terms…

  5. Empirically and Clinically Useful Decision Making in Psychotherapy: Differential Predictions with Treatment Response Models

    ERIC Educational Resources Information Center

    Lutz, Wolfgang; Saunders, Stephen M.; Leon, Scott C.; Martinovich, Zoran; Kosfelder, Joachim; Schulte, Dietmar; Grawe, Klaus; Tholen, Sven

    2006-01-01

    In the delivery of clinical services, outcomes monitoring (i.e., repeated assessments of a patient's response to treatment) can be used to support clinical decision making (i.e., recurrent revisions of outcome expectations on the basis of that response). Outcomes monitoring can be particularly useful in the context of established practice research…

  6. Empirical Correlates and Expanded Interpretation of the MMPI-2-RF Restructured Clinical Scale 3 (Cynicism)

    ERIC Educational Resources Information Center

    Ingram, Paul B.; Kelso, Kristy M.; McCord, David M.

    2011-01-01

    The recent release of the Minnesota Multiphasic Personality Inventory-2-Restructured Form (MMPI-2-RF) has received much attention from the clinical psychology community. Particular concerns have focused on Restructured Clinical Scale 3 (RC3; Cynicism). This article briefly reviews the major criticisms and responses regarding the restructuring of…

  7. Online Behavior in Virtual Space: An Empirical Study on Helping

    ERIC Educational Resources Information Center

    Hsu, Jung-Lung; Hwang, Wu-Yuin; Huang, Yueh-Min; Liu, Jui-Jung

    2011-01-01

    Although previous studies have acknowledged that helping behavior has many potential benefits, little research has aimed at understanding which factors would possibly enhance helping behaviors among team members in CSCL environment. Accordingly, this study was intended to identify underlying factors leading learners to collaborate in virtual CSCL…

  8. Psychological Determinants of University Students' Academic Performance: An Empirical Study

    ERIC Educational Resources Information Center

    Gebka, Bartosz

    2014-01-01

    This study utilises an integrated conceptual model of academic performance which captures a series of psychological factors: cognitive style; self-theories such as self-esteem and self-efficacy; achievement goals such as mastery, performance, performance avoidance and work avoidance; study-processing strategies such as deep and surface learning;…

  9. An Empirical Study of a Solo Performance Assessment Model

    ERIC Educational Resources Information Center

    Russell, Brian E.

    2015-01-01

    The purpose of this study was to test a hypothesized model of solo music performance assessment. Specifically, this study investigates the influence of technique and musical expression on perceptions of overall performance quality. The Aural Musical Performance Quality (AMPQ) measure was created to measure overall performance quality, technique,…

  10. Academic Probation: An Empirical Study of Private University Students

    ERIC Educational Resources Information Center

    Ahmed, Jashim Uddin; Chowdhury, Md. Humayun Kabir; Rahman, Sheehan; Talukder, A. K. M. Mominul Haque

    2014-01-01

    This study examines the factors contributing to academic probation in university settings and highlights the problems that students encounter in higher education institutions in Bangladesh. The study focused on students facing academic probation on two private universities in Bangladesh and analyzed students' response with respect to nine…

  11. Trend extraction using empirical mode decomposition and statistical empirical mode decomposition: Case study: Kuala Lumpur stock market

    NASA Astrophysics Data System (ADS)

    Jaber, Abobaker M.

    2014-12-01

    Two nonparametric methods for prediction and modeling of financial time series signals are proposed. The proposed techniques are designed to handle non-stationary and non-linearity behave and to extract meaningful signals for reliable prediction. Due to Fourier Transform (FT), the methods select significant decomposed signals that will be employed for signal prediction. The proposed techniques developed by coupling Holt-winter method with Empirical Mode Decomposition (EMD) and it is Extending the scope of empirical mode decomposition by smoothing (SEMD). To show performance of proposed techniques, we analyze daily closed price of Kuala Lumpur stock market index.

  12. From empirical to mechanism-based discovery of clinically useful Selective Estrogen Receptor Modulators (SERMs)

    PubMed Central

    Wardell, Suzanne E.; Nelson, Erik R.; McDonnell, Donald P.

    2014-01-01

    Our understanding of the molecular mechanisms underlying the pharmacological actions of estrogen receptor (ER) ligands has evolved considerably in recent years. Much of this knowledge has come from a detailed dissection of the mechanism(s) of action of the Selective Estrogen Receptor Modulators (SERMs) tamoxifen and raloxifene, drugs whose estrogen receptor (ER) agonist/antagonist properties are influenced by the cell context in which they operate. These studies have revealed that notwithstanding differences in drug pharmokinetics, the activity of an ER ligand is determined primarily by (a) the impact that a given ligand has on the receptor conformation and (b) the ability of structurally distinct ER-ligand complexes to interact with functionally distinct coregulators. Exploitation of the established relationships between ER structure and activity has led to the development of improved SERMs with more favorable therapeutic properties and of tissue-selective estrogen complexes, drugs in which a SERM and an ER agonist are combined to yield a blended activity that results in distinct clinical profiles. Remarkably, endogenous ligands that exhibit SERM activity have also been identified. One of these ligands, 27-hydroxycholesterol (27HC), has been shown to manifest ER-dependent pathological activities in the cardiovascular system, bone and mammary gland. Whereas the physiological activity of 27HC remains to be determined, its discovery highlights how cells have adopted mechanisms to allow the same receptor ligand complex to manifest different activities in different cells, and also how these processes can be exploited for new drug development. PMID:25084324

  13. Clinicians' emotional responses and Psychodynamic Diagnostic Manual adult personality disorders: A clinically relevant empirical investigation.

    PubMed

    Gazzillo, Francesco; Lingiardi, Vittorio; Del Corno, Franco; Genova, Federica; Bornstein, Robert F; Gordon, Robert M; McWilliams, Nancy

    2015-06-01

    The aim of this study is to explore the relationship between level of personality organization and type of personality disorder as assessed with the categories in the Psychodynamic Diagnostic Manual (PDM; PDM Task Force, 2006) and the emotional responses of treating clinicians. We asked 148 Italian clinicians to assess 1 of their adult patients in treatment for personality disorders with the Psychodiagnostic Chart (PDC; Gordon & Bornstein, 2012) and the Personality Diagnostic Prototype (PDP; Gazzillo, Lingiardi, & Del Corno, 2012) and to complete the Therapist Response Questionnaire (TRQ; Betan, Heim, Zittel-Conklin, & Westen, 2005). The patients' level of overall personality pathology was positively associated with helpless and overwhelmed responses in clinicians and negatively associated with positive emotional responses. A parental and disengaged response was associated with the depressive, anxious, and dependent personality disorders; an exclusively parental response with the phobic personality disorder; and a parental and criticized response with narcissistic disorder. Dissociative disorder evoked a helpless and parental response in the treating clinicians whereas somatizing disorder elicited a disengaged reaction. An overwhelmed and disengaged response was associated with sadistic and masochistic personality disorders, with the latter also associated with a parental and hostile/criticized reaction; an exclusively overwhelmed response with psychopathic patients; and a helpless response with paranoid patients. Finally, patients with histrionic personality disorder evoked an overwhelmed and sexualized response in their clinicians whereas there was no specific emotional reaction associated with the schizoid and the obsessive-compulsive disorders. Clinical implications of these findings were discussed.

  14. Using MultiMedia Content to Present Business Ethics: An Empirical Study

    ERIC Educational Resources Information Center

    Stanwick, Peter A.

    2010-01-01

    The purpose of this study is to empirically examine whether presenting a multimedia case study enhances the learning experience of students in an undergraduate management class. A questionnaire was administered before and after the presentation of the case study and the results showed that the multimedia case did indeed enhance the learning…

  15. Using ERP and WfM Systems for Implementing Business Processes: An Empirical Study

    NASA Astrophysics Data System (ADS)

    Aversano, Lerina; Tortorella, Maria

    Software systems mainly considered from enterprises for dealing with a business process automation belong to the following two categories: Workflow Management Systems (WfMS) and Enterprise Resource Planning (ERP) systems. The wider diffusion of ERP systems tends to favourite this solution, but there are several limitations of most ERP systems for automating business processes. This paper reports an empirical study aiming at comparing the ability of implementing business processes of ERP systems and WfMSs. Two different case studies have been considered in the empirical study. It evaluates and analyses the correctness and completeness of the process models implemented by using ERP and WfM systems.

  16. User acceptance of mobile commerce: an empirical study in Macau

    NASA Astrophysics Data System (ADS)

    Lai, Ivan K. W.; Lai, Donny C. F.

    2014-06-01

    This study aims to examine the positive and negative factors that can significantly explain user acceptance of mobile commerce (m-commerce) in Macau. A technology acceptance model for m-commerce with five factors is constructed. The proposed model is tested using data collected from 219 respondents. Confirmatory factor analysis is performed to examine the reliability and validity of the model, and structural equation modelling is performed to access the relationship between behaviour intention and each factor. The acceptance of m-commerce is influenced by factors including performance expectancy, social influence, facilitating conditions and privacy concern; while effort expectancy is insignificant in this case. The results of the study are useful for m-commerce service providers to adjust their strategies for promoting m-commerce services. This study contributes to the practice by providing a user technology acceptance model for m-commerce that can be used as a foundation for future research.

  17. Website Service Quality in Ireland: An Empirical Study

    NASA Astrophysics Data System (ADS)

    Connolly, Regina

    Despite the fact that service quality is a critical determinant of website success, studies show that consumers frequently view the service quality delivered through websites as unsatisfactory. This paper outlines a study that investigated the dimensions of website service excellence valued by Irish customers of a small-to-medium enterprise specialising in gifts. The E-S-QUAL measurement instrument was applied to the customers who purchase products online from this retailer, in order to determine their purchasing patterns and the dimensions of e-service quality that they value. The results of this study indicate the effectiveness of the instrument in determining gaps in e-service quality. The findings will be of benefit both to practitioners and researchers seeking to improve their understanding of the factors that contribute towards the creation and maintenance of consumer satisfaction in Irish online transactions.

  18. Sustaining the environment through recycling: an empirical study.

    PubMed

    Ramayah, T; Lee, Jason Wai Chow; Lim, Shuwen

    2012-07-15

    This paper examines the determinants of recycling behaviour among 200 university students from the perspective of the theory of planned behaviour (TPB). Data was analysed using Structural Equation Modelling technique. Findings indicate that environmental awareness was significantly related to attitude towards recycling, whilst attitude and social norms had significant impact on recycling behaviour. However, convenience and cost of recycling were not significant reasons for recycling. The study has enhanced the understanding of the determinants of recycling behaviour and has implications for schools and governmental agencies in educating and encouraging positive recycling behaviour. It also confirms the appropriateness of the TPB in examining studies of this nature. Further suggestions for future research are offered.

  19. Student Stress in an FE College: An Empirical Study.

    ERIC Educational Resources Information Center

    Hayward, Abbe; Stott, Clare

    1998-01-01

    A study was conducted of student stress in a further education (FE) college in northwest England. In collaboration with the college, two questionnaires were developed, one for the teaching staff and the other for the students. Questionnaires were distributed to 69 staff and 1,100 students, with a response rate of 94 percent from staff and 84…

  20. Group Performance in Information Systems Project Groups: An Empirical Study

    ERIC Educational Resources Information Center

    Bahli, Bouchaib; Buyukkurt, Meral Demirbag

    2005-01-01

    The importance of teamwork in Information Systems Development (ISD) practice and education has been acknowledged but not studied extensively to date. This paper tests a model of how groups participating in ISD projects perform and examines the relationships between some antecedents of this performance based on group research theory well…

  1. An Empirical Study of State University Students' Perceived Service Quality

    ERIC Educational Resources Information Center

    Sumaedi, Sik; Bakti, Gede Mahatma Yuda; Metasari, Nur

    2012-01-01

    Purpose: This paper aims to identify: university students' perceived service quality dimensions; the dimensions contributing most towards overall students' perceived service quality; and whether there is a difference in perceived quality level of each dimension based on students' year of study and gender in the context of undergraduate students of…

  2. Creativity and Tolerance of Ambiguity: An Empirical Study

    ERIC Educational Resources Information Center

    Zenasni, Franck; Besancon, Maud; Lubart, Todd

    2008-01-01

    This study examines the relationship between creativity and tolerance of ambiguity. Participants were parents and their adolescent children. Three measures of creativity were used: a divergent thinking task, a story-writing task and self-evaluation of creative attitudes and behavior. Participants completed two self-report measures of tolerance of…

  3. College of Business Majors' Perceptions toward Globalization: An Empirical Study

    ERIC Educational Resources Information Center

    Janavaras, Basil; Kuzma, John; Thiewes, Harold

    2008-01-01

    The objective of this paper is to determine the extent to which business majors' attitudes towards globalization are influenced by the area of selected study. Research has documented that more favorable attitudes towards globalization are found among college students, and specifically, these more favorable attitudes are found in business majors.…

  4. An Empirical Study of Graduate Student Mobility Underpinning Research Universities

    ERIC Educational Resources Information Center

    Furukawa, Takao; Shirakawa, Nobuyuki; Okuwada, Kumi

    2013-01-01

    The issue of international student mobility has had a profound effect on policy decision-making in the higher education system of essentially every country; however, the statistical data on this subject are insufficient, especially for graduate students. The purposes of this study are to substantiate the state of international mobility among…

  5. Similarity Attraction in Learning Contexts: An Empirical Study

    ERIC Educational Resources Information Center

    Varela, Otmar E.; Cater, John James, III; Michel, Norbert

    2011-01-01

    This study tests a process model of learning in which trainer and trainee traits are simultaneously considered as endogenous variables of learning outcomes. The article builds on a social view of training and similarity-attraction paradigms. In this context, the authors hypothesize that trainer-trainee similarity in personality (agreeableness)…

  6. Self-Efficacy and IPS: An Empirical Study

    ERIC Educational Resources Information Center

    McLeod, Linda P.

    2015-01-01

    The fact that some learners learn language more successfully than others who are at the same level of aptitude and capabilities is inevitable. To understand why, the researcher has focused her attention on individual differences among learners. The ones that have been taken into account in this study are namely called self-efficacy and identity…

  7. Creativity, Schizotypicality, and Mystical Experience: An Empirical Study

    ERIC Educational Resources Information Center

    Michalica, Kerri; Hunt, Harry

    2013-01-01

    This study examined the commonalities and the differences between creativity and the schizophrenia spectrum. The variables measured were creativity, schizotypy, absorption, mystical experiences, spatial ability, balance, positive and negative presence, and neuroticism. Three community groups were recruited: 31 artists, 10 people with…

  8. HRD Interventions, Employee Competencies and Organizational Effectiveness: An Empirical Study

    ERIC Educational Resources Information Center

    Potnuru, Rama Krishna Gupta; Sahoo, Chandan Kumar

    2016-01-01

    Purpose: The purpose of the study is to examine the impact of human resource development (HRD) interventions on organizational effectiveness by means of employee competencies which are built by some of the selected HRD interventions. Design/methodology/approach: An integrated research model has been developed by combining the principal factors…

  9. An Empirical Study on Students' Ability to Comprehend Design Patterns

    ERIC Educational Resources Information Center

    Chatzigeorgiou, Alexander; Tsantalis, Nikolaos; Deligiannis, Ignatios

    2008-01-01

    Design patterns have become a widely acknowledged software engineering practice and therefore have been incorporated in the curricula of most computer science departments. This paper presents an observational study on students' ability to understand and apply design patterns. Within the context of a postgraduate software engineering course,…

  10. Study Abroad Programs and American Student Worldmindedness: An Empirical Analysis.

    ERIC Educational Resources Information Center

    Douglas, Ceasar; Jones-Rikkers, Catherine G.

    2001-01-01

    Surveyed the worldmindedness (extent to which individuals value global perspectives on various issues) of students participating in study abroad programs designed to increase their exposure to different cultural contexts. Found that such programs do have a positive impact on development of worldmindedness, and that the level of difference between…

  11. Job Satisfaction of Academic Staff: An Empirical Study on Turkey

    ERIC Educational Resources Information Center

    Toker, Boran

    2011-01-01

    Purpose: The purpose of this paper is to investigate the levels of job satisfaction among academicians in the universities of Turkey and to examine the effects of demographics on levels of satisfaction among them. Design/methodology/approach: A questionnaire-based study was conducted in 648 academicians working in the Universities of Turkey. Data…

  12. The Depth and Breadth of Google Scholar: An Empirical Study

    ERIC Educational Resources Information Center

    Neuhaus, Chris; Neuhaus, Ellen; Asher, Alan; Wrede, Clint

    2006-01-01

    The introduction of Google Scholar in November 2004 was accompanied by fanfare, skepticism, and numerous questions about the scope and coverage of this database. Nearly one year after its inception, many of these questions remain unanswered. This study compares the contents of 47 different databases with that of Google Scholar. Included in this…

  13. Management Education Program Evaluation: An Empirical Study in Mainland China

    ERIC Educational Resources Information Center

    Sou, Gryphon; Zhou, Pinqiu

    2007-01-01

    Background: With the accession of the PRC to the WTO, Chinese education market is open to the educational service providers of the foreign countries. They are keen to offer MBA Degree programs to the Career Managers in the Mainland. Aims: This research studies program evaluation and so forth the quality assessment of a MBA degree program in the…

  14. Effect of Geographic Distance on Distance Education: An Empirical Study

    ERIC Educational Resources Information Center

    Luo, Heng; Robinson, Anthony C.; Detwiler, Jim

    2014-01-01

    This study investigates the effect of geographic distance on students' distance learning experience with the aim to provide tentative answers to a fundamental question--does geographic distance matter in distance education? Using educational outcome data collected from an online master's program in Geographic Information Systems, this study…

  15. Research Compensation and Lottery: An Online Empirical Pilot Study

    ERIC Educational Resources Information Center

    Zangeneh, Masood; Barmaki, Reza; Gibson-Wood, Hilary; Levitan, Michael-Jane; Romeo, Rosemary; Bottoms, Jennifer

    2008-01-01

    Recruiting participants for a research project can be challenging. Incentives, particularly monetary incentives, have been shown to increase response rates. Offering a monetary incentive for participation in a research study can become very costly for the investigators. For this reason some researchers, including graduate students involved in…

  16. An Empirical Study of Reporting Practices Concerning Measurement Validity

    ERIC Educational Resources Information Center

    Hogan, Thomas P.; Agnello, Jessica

    2004-01-01

    This study investigates the current research practice concerning reporting measurement validity evidence based on a sample of 696 research reports listed in the American Psychological Association's Directory of Unpublished Experimental Mental Measures. Only 55% of the reports included any type of validity evidence. This was a substantially lower…

  17. Factors Affecting Softlifting Intention of Computing Students: An Empirical Study.

    ERIC Educational Resources Information Center

    Rahim, Md. Mahbubur; Seyal, Afzaal H.; Rahman, Mohd. Noah Abd.

    2001-01-01

    Discusses softlifting as a form of software piracy and describes a study that analyzed the softlifting intentions of computing students in Brunei Darussalam. Considers student attitudes; gender; family income; personal computer ownership; experience; faculty remarks; institutional monitoring; and implications for attempts to curb software piracy.…

  18. IT Entrepreneurial Intention among College Students: An Empirical Study

    ERIC Educational Resources Information Center

    Chen, Liqiang

    2013-01-01

    IT (Information Technology) entrepreneurs have been contributing greatly to economic growth and job creation. Despite its importance, IT entrepreneurship remains understudied in business research. Particularly, the study of IT entrepreneurial behavior has been ignored in both Information Systems (IS) and entrepreneurship disciplines. Utilizing the…

  19. Aspect-Oriented Approach to Operating System Development Empirical Study

    NASA Astrophysics Data System (ADS)

    Kuusela, Jaakko; Tuominen, Harri

    This paper presents a case-study where a new programming technique is applied to an established branch of software development. The purpose of the study was to test whether or not aspect-oriented programming (AOP) could be used in operating systems development. Instead of any real world operating system an educational OS with the name Nachos was used. This was because Nachos is written in Java which makes it easy to introduce aspect-oriented techniques. In this paper a new file system for the Nachos OS is developed and then it is analyzed by profiling and metrics. The results show that it is possible to use AOP in OS development and that it is also beneficial to do so.

  20. An Empirical Study of Earth Covered Schools in Oklahoma.

    DTIC Science & Technology

    1979-11-01

    Director, Defense Nuclear Agency Division of Biology and Medicine Attn: Mr. Torn Kenned- Atornic Energy Commission Washington, D. C. 20305 ^tt-: Mr...studies of underground structures in general and the Oklahoma schools in particular. Several were found. Limited measurement of the energy saving potential...suggests it is real, and significant; a sixty percent saving in energy was found to be likely without any specific effort at energy efficient design

  1. A Formulative and Empirical Study of Black Families. Final Report.

    ERIC Educational Resources Information Center

    Nobles, Wade; And Others

    This research study on the black family was based on the position that black culture in the U.S. is the result of a special admixture of the continuation of an African world-view or cultural perspective which operates within the perspective of an Anglo-American world-view. Because this research is guided by this position, it is viewed as a…

  2. Portuguese validation of the Internet Addiction Test: An empirical study

    PubMed Central

    PONTES, HALLEY M.; PATRÃO, IVONE M.; GRIFFITHS, MARK D.

    2014-01-01

    Background and aims: Research into Internet addiction (IA) has increased greatly over the last decade. Despite its various definitions and general lack of consensus regarding its conceptualisation amongst researchers, instruments for measuring this phenomenon have proliferated in a number of countries. There has been little research on IA in Portugal and this may be partly due to the absence of standardised measurement tools for assessing IA. Methods: This study attempted to address this issue by adapting a Portuguese version of the Internet Addiction Test (IAT) via a translation-back translation process and Confirmatory Factor Analysis in a sample of 593 Portuguese students that completed a Portuguese version of the IAT along with questions related to socio-demographic variables. Results: The findings suggested that the IAT appears to be a valid and reliable instrument for measuring IA among Portuguese young adults as demonstrated by its satisfactory psychometric properties. However, the present findings also suggest the need to reword and update some of the IAT’s items. Prevalence of IA found in the sample was 1.2% and is discussed alongside findings relating to socio-demographic correlates. Limitations and implications of the present study are also discussed. Conclusions: The present study calls for a reflection of the IAT while also contributing to a better understanding of the basic aspects of IA in the Portuguese community since many health practitioners are starting to realise that Internet use may pose a risk for some individuals. PMID:25215221

  3. An empirical study of economies of scope in home healthcare.

    PubMed Central

    Gonzales, T I

    1997-01-01

    OBJECTIVE: To apply the economic theory of economies of scope to the home healthcare industry. DATA SOURCES: Data on 488 observations obtained from the Cost Report (HCFA Form 1728-86) of all Connecticut state-licensed, Medicare-certified home health agencies. STUDY DESIGN: The Cost Report was the primary source of data for this study. Information on total cost, scope, and other related factors was collected. Logarithmic and nonlinear regression analyses were used to identify factors related to scope and also to test for economies of scope. DATA COLLECTION METHOD: Data collected were both cross-sectional and time series (from 1988-1992). Data accuracy was verified using description of frequencies, measures of central tendency and variation, and a calculation package so that a computer calculation on the data could be compared with the agency's calculation. PRINCIPAL FINDINGS: It was determined that initially as scope increases, costs go down, thus proving economies of scope. For larger values of scope, it was determined that costs go up, proving diseconomies of scope. CONCLUSIONS: Many of the home health agencies included in this study provide more services than is cost effective given the economic theory of economies of scope. PMID:9240283

  4. An empirical study of early childhood support through partnership building.

    PubMed

    Wang, Jianjun; Ortiz, Theresa; Navarro, Diana; Maier, Roland; Wang, Summer; Wang, Lisa; Wang, Libing

    2016-12-01

    The first five years were recognized as a critical period of child growth. Accordingly, California voters approved tobacco tax through Proposition 10 to fund early childhood services since 1998. Due to the state revenue decline, Service Integration has been advocated to enhance program supports in Child Health, Family Functioning, and Child Development. In this study, interview data are analyzed to examine the partnership building among 40 programs. The results indicate a significant impact of the service outreach across remote communities in Kern County, California. In addition, contextual information is provided to facilitate interpretation of the partnership strength from a social network analysis. Enhancement of this investigation is discussed in light of future development.

  5. Dissociation, PTSD, and Substance Abuse: An Empirical Study

    PubMed Central

    Najavits, Lisa; Walsh, Marybeth

    2012-01-01

    Few studies have examined the relationship between posttraumatic stress disorder (PTSD), substance use disorder (SUD) and dissociation. We studied 77 women with current PTSD and substance dependence, classified into high- versus low-dissociation on the Dissociative Experiences Scale. They were compared on trauma- and substance-related symptoms, cognitions, coping skills, social adjustment, trauma history, psychiatric symptoms, and self-harm/suicidal behaviors. We found the high-dissociation group consistently more impaired than the low-dissociation group. Also, the sample overall evidenced relatively high levels of dissociation, indicating that even in the presence of recent substance use, dissociation remains a major psychological phenomenon. Indeed, the high-dissociation group reported stronger expectation that substances could manage their psychiatric symptoms. The high-dissociation group also had more trauma-related symptoms and childhood histories of emotional abuse and physical neglect. Discussion addresses methodology, the “chemical dissociation” hypothesis, and the need for more nuanced understanding of how substances are experienced in relation to dissociative phenomena. PMID:22211445

  6. Ontogeny of dreaming: a review of empirical studies.

    PubMed

    Sándor, Piroska; Szakadát, Sára; Bódizs, Róbert

    2014-10-01

    The examination of children's sleep-related mental experiences presents many significant challenges for researchers investigating the developmental trajectories of human dreaming. In contrast to the well-explored developmental patterns of human sleep, data from dream research are strikingly divergent with highly ambiguous results and conclusions, even though there is plenty of indirect evidence suggesting parallel patterns of development between neural maturation and dreaming. Thus results from studies of children's dreaming are of essential importance not only to enlighten us on the nature and role of dreaming but to also add to our knowledge of consciousness and cognitive and emotional development. This review summarizes research results related to the ontogeny of dreaming: we critically reconsider the field, systematically compare the findings based on different methodologies, and highlight the advantages and disadvantages of methods, arguing in favor of methodological pluralism. Since most contradictory results emerge in connection with descriptive as well as content related characteristics of young children's dreams, we emphasize the importance of carefully selected dream collection methods. In contrast nightmare-related studies yield surprisingly convergent results, thus providing strong basis for inferences about the connections between dreaming and cognitive emotional functioning. Potential directions for dream research are discussed, aiming to explore the as yet unraveled correlations between the maturation of neural organization, sleep architecture and dreaming patterns.

  7. Consolidated View on Space Software Engineering Problems - An Empirical Study

    NASA Astrophysics Data System (ADS)

    Silva, N.; Vieira, M.; Ricci, D.; Cotroneo, D.

    2015-09-01

    Independent software verification and validation (ISVV) has been a key process for engineering quality assessment for decades, and is considered in several international standards. The “European Space Agency (ESA) ISVV Guide” is used for the European Space market to drive the ISVV tasks and plans, and to select applicable tasks and techniques. Software artefacts have room for improvement due to the amount if issues found during ISVV tasks. This article presents the analysis of the results of a large set of ISVV issues originated from three different ESA missions-amounting to more than 1000 issues. The study presents the main types, triggers and impacts related to the ISVV issues found and sets the path for a global software engineering improvement based on the most common deficiencies identified for space projects.

  8. Short Stories via Computers in EFL Classrooms: An Empirical Study for Reading and Writing Skills

    ERIC Educational Resources Information Center

    Yilmaz, Adnan

    2015-01-01

    The present empirical study scrutinizes the use of short stories via computer technologies in teaching and learning English language. The objective of the study is two-fold: to examine how short stories could be used through computer programs in teaching and learning English and to collect data about students' perceptions of this technique via…

  9. Using an Empirical Binomial Hierarchical Bayesian Model as an Alternative to Analyzing Data from Multisite Studies

    ERIC Educational Resources Information Center

    Hardin, J. Michael; Anderson, Billie S.; Woodby, Lesa L.; Crawford, Myra A.; Russell, Toya V.

    2008-01-01

    This article explores the statistical methodologies used in demonstration and effectiveness studies when the treatments are applied across multiple settings. The importance of evaluating and how to evaluate these types of studies are discussed. As an alternative to standard methodology, the authors of this article offer an empirical binomial…

  10. An Empirical Study of Communication between Teachers and Students in Colleges and Universities

    ERIC Educational Resources Information Center

    Tingyong, Zhou; Zuoyu, Zhou

    2006-01-01

    As an empirical study based on multiple linear regression analysis of the investigation data, this paper studies the communication between teachers and students in universities. It reveals that the interaction between university teachers and students promotes the personal development of college students. For some reason, however, a rather low…

  11. Teachers' Pedagogical Beliefs at Commercial Schools--An Empirical Study in Germany

    ERIC Educational Resources Information Center

    Seifried, Juergen

    2012-01-01

    Within the study of teacher training, it is generally accepted that a teacher's behaviour and success in the classroom is influenced by their personal beliefs. This paper discusses teachers' pedagogical beliefs, domain-specific beliefs and conceptions of teaching and learning. We outline empirical results from various studies which explore…

  12. Personality Traits, Sexual Problems, and Sexual Orientation: An Empirical Study.

    PubMed

    Peixoto, Maria Manuela; Nobre, Pedro

    2016-01-01

    Personality traits, namely neuroticism, have been suggested as vulnerability factors for the development and maintenance of sexual dysfunction in heterosexual samples. However, no evidence was found regarding homosexual samples. This study aimed to analyze the differences on personality traits between heterosexual and homosexual men and women with and without sexual problems. Participants were 285 individuals (142 men, 143 women) who completed a web-based survey. Participants answered the NEO Five-Factor Inventory, the Brief Symptomatology Inventory, and questions regarding sexual problems. The groups of men and women with and without sexual problems were matched for sociodemographic variables. A 2 (Group) × 2 (Sexual Orientation) multivariate analysis of covariance was conducted separately for each gender. Results indicated a significant main effect for group and for sexual orientation in male and female samples. Men with sexual problems scored higher on neuroticism, whereas women with sexual problems scored higher on neuroticism and lower on extraversion when compared with healthy controls, regardless of sexual orientation. In addition, gay men scored higher on neuroticism and lesbian women scored higher on conscientiousness compared with the heterosexual groups. The present findings emphasize the central role of neuroticism on sexual problems in both men and women regardless of sexual orientation.

  13. [Patient satisfaction and geriatric care - an empirical study].

    PubMed

    Clausen, G; Borchelt, M; Janssen, C; Loos, S; Mull, L; Pfaff, H

    2006-02-01

    Patients' satisfaction has become a central concept in quality assurance. Despite progress in research in this area is still a lack of data for geriatric patients. Referring to the consumer model, satisfaction can be described as a difference between expectations and assessed performance. The aim of this study is to analyze satisfaction among geriatric patients in an in-patient setting. A personal interview was performed 1-2 days before discharge. Patients suffering for dementia or with problems to communicate were excluded. 124 of 268 geriatric patients who were discharged in 2003 were included (inclusion rate 46.3%). 119 were willing to participate (response rate 96.0%). Respondents were between 61 and 96 years old, 39% were male and 42% had serious functional limitations at time of admission. Multiple linear regression analysis revealed three significant predictors of a combined index of satisfaction and expectations: a) quality of hotel services; b) experience of neglect; c) provision of medical information and skills. In summary, standardized personal questionnaires can provide valid and reliable data of geriatric patients. Satisfaction of elderly patients is negatively affected by neglect and positively influenced by provision of medical information and a good hotel services.

  14. Empirical study of simulated two-planet microlensing events

    SciTech Connect

    Zhu, Wei; Gould, Andrew; Penny, Matthew; Mao, Shude; Gendron, Rieul

    2014-10-10

    We undertake the first study of two-planet microlensing models recovered from simulations of microlensing events generated by realistic multiplanet systems in which 292 planetary events, including 16 two-planet events, were detected from 6690 simulated light curves. We find that when two planets are recovered, their parameters are usually close to those of the two planets in the system most responsible for the perturbations. However, in 1 of the 16 examples, the apparent mass of both detected planets was more than doubled by the unmodeled influence of a third, massive planet. This fraction is larger than but statistically consistent with the roughly 1.5% rate of serious mass errors due to unmodeled planetary companions for the 274 cases from the same simulation in which a single planet is recovered. We conjecture that an analogous effect due to unmodeled stellar companions may occur more frequently. For 7 out of 23 cases in which two planets in the system would have been detected separately, only one planet was recovered because the perturbations due to the two planets had similar forms. This is a small fraction (7/274) of all recovered single-planet models, but almost a third of all events that might plausibly have led to two-planet models. Still, in these cases, the recovered planet tends to have parameters similar to one of the two real planets most responsible for the anomaly.

  15. An empirical study of Freud's penis-baby equation.

    PubMed

    Jones, R L

    1994-03-01

    One hypothesis of traditional psychoanalytic theory holds that a cardinal aspect of the "natural" development of femininity involves the woman's substitution of the wish for a baby in place of her original wish for a penis. The current study modified and extended earlier research examining the validity of Freud's this "penis-baby" theory. College-aged women and men were presented with either subliminal or supraliminal auditory messages concerned with either pregnancy or penetration themes. Subjects' written responses to Holtzman ink-blots, obtained both before and after exposure to an auditory message, were content-coded for phallic imagery and sexual imagery. Consistent with Freud's speculations about the phallic significance of pregnancy for women, female subjects who were exposed to the subliminal pregnancy message produced significantly more phallic imagery responses to ink-blots than did women in any of the other experimental conditions (p < .01). The phallic imagery production of males did not vary significantly as a function of message condition. Implications of these findings are discussed in the context of modern revisions to Freud's psychology of women and the current psychoanalytic conceptualization of penis envy as a highly condensed mental product with many layers of meaning.

  16. Empirical study of alginate impression materials by customized proportioning system

    PubMed Central

    2016-01-01

    PURPOSE Alginate mixers available in the market do not have the automatic proportioning unit. In this study, an automatic proportioning unit for the alginate mixer and controller software were designed and produced for a new automatic proportioning unit. With this device, it was ensured that proportioning operation could arrange weight-based alginate impression materials. MATERIALS AND METHODS The variation of coefficient in the tested groups was compared with the manual proportioning. Compression tension and tear tests were conducted to determine the mechanical properties of alginate impression materials. The experimental data were statistically analyzed using one way ANOVA and Tukey test at the 0.05 level of significance. RESULTS No statistically significant differences in modulus of elastisity (P>0.3), tensional/compresional strength (P>0.3), resilience (P>0.2), strain in failure (P>0.4), and tear energy (P>0.7) of alginate impression materials were seen. However, a decrease in the standard deviation of tested groups was observed when the customized machine was used. To verify the efficiency of the system, powder and powder/water mixing were weighed and significant decrease was observed. CONCLUSION It was possible to obtain more mechanically stable alginate impression materials by using the custom-made proportioning unit. PMID:27826387

  17. The adoption of mobile health management services: an empirical study.

    PubMed

    Hung, Ming-Chien; Jen, Wen-Yuan

    2012-06-01

    As their populations age, many countries are facing the increasing economic pressure of providing healthcare to their people. In Taiwan, this problem is exacerbated by an increasing rate of obesity and obesity-related conditions. Encouraging the adoption of personal health management services is one way to maintain current levels of personal health and to efficiently manage the distribution of healthcare resources. This study introduces Mobile Health Management Services (MHMS) and employs the Technology Acceptance Model (TAM) to explore the intention of students in Executive Master of Business Management programs to adopt mobile health management technology. Partial least squares (PLS) was used to analyze the collected data, and the results revealed that "perceived usefulness" and "attitude" significantly affected the behavioral intention of adopting MHMS. Both "perceived ease of use" and "perceived usefulness," significantly affected "attitude," and "perceived ease of use" significantly affected "perceived usefulness" as well. The results also show that the determinants of intention toward MHMS differed with age; young adults had higher intention to adopt MHMS to manage their personal health. Therefore, relevant governmental agencies may profitably promote the management of personal health among this population. Successful promotion of personal health management will contribute to increases in both the level of general health and the efficient management of healthcare resources.

  18. Global warming and global dioxide emission: An empirical study

    SciTech Connect

    Linyan Sun; Wang, M.

    1996-04-01

    In this paper, the dynamic relationship between global surface temperature (global warming) and global carbon dioxide emission (CO{sub 2}) is modelled and analyzed by causality and spectral analysis in the time domain and frequency domain, respectively. Historical data of global CO{sub 2} emission and global surface temperature anomalies over 129 years from 1860-1988 are used in this study. The causal relationship between the two phenomena is first examined using the Sim and Granger causality test in the time domain after the data series are filtered by ARIMA models. The Granger causal relationship is further scrutinized and confirmed by cross-spectral and multichannel spectral analysis in the frequency domain. The evidence found from both analyses proves that there is a positive causal relationship between the two variables. The time domain analysis suggests that Granger causality exists between global surface temperature and global CO{sub 2} emission. Further, CO{sub 2} emission causes the change in temperature. The conclusions are further confirmed by the frequency domain analysis, which indicates that the increase in CO{sub 2} emission causes climate warming because a high coherence exists between the two variables. Furthermore, it is proved that climate changes happen after an increase in CO{sub 2} emission, which confirms that the increase in CO{sub 2} emission does cause global warming. 27 refs., 10 figs., 5 tabs.

  19. Reasons for not reporting adverse incidents: an empirical study.

    PubMed

    Vincent, C; Stanhope, N; Crowley-Murphy, M

    1999-02-01

    A previous study (Stanhope et al. 1998) established that staff in two obstetric units reported less than a quarter of designated incidents to the units' risk managers. A questionnaire was administered to 42 obstetricians and 156 midwives at the same two obstetric units, exploring the reasons for low rates of reporting. Questions concerned their knowledge of their unit's incident reporting system; whether they would report a series of 10 designated adverse obstetric incidents to the risk manager; and their views on 12 potential reasons for not reporting incidents. Most staff knew about the incident-reporting system in their unit, but almost 30% did not know how to find a list of reportable incidents. Views on the necessity of reporting the 10 designated obstetric incidents varied considerably. For example, 96% of staff stated they would always report a maternal death, whereas less than 40% would report a baby's unexpected admission to the Special Care Baby Unit. Midwives said they were more likely to report incidents than doctors, and junior staff were more likely to report than senior staff. The main reasons for not reporting were fears that junior staff would be blamed, high workload and the belief (even though the incident was designated as reportable) that the circumstances or outcome of a particular case did not warrant a report. Junior doctors felt less supported by their colleagues than senior doctors. Current systems of incident reporting, while providing some valuable information, do not provide a reliable index of the rate of adverse incidents. Recommended measures to increase reliability include clearer definitions of incidents, simplified methods of reporting, designated staff to record incidents and education, feedback and reassurance to staff about the nature and purpose of such systems.

  20. In Search of the Unifying Principles of Psychotherapy: Conceptual, Empirical, and Clinical Convergence

    ERIC Educational Resources Information Center

    Magnavita, Jeffrey J.

    2006-01-01

    The search for the principles of unified psychotherapy is an important stage in the advancement of the field. Converging evidence from various streams of clinical science allows the identification of some of the major domains of human functioning, adaptation, and dysfunction. These principles, supported by animal modeling, neuroscience, and…

  1. Chinese Fantasy Novel: Empirical Study on New Word Teaching for Non-Native Learners

    ERIC Educational Resources Information Center

    Meng, Bok Check; Soon, Goh Ying

    2014-01-01

    Giving additional learning materials such as Chinese fantasy novel to non-native learners can be strenuous. This study seeks to render empirical support on the usefulness of the use of new words in Chinese fantasy novel to enhance vocabulary learning among the non-native learners of Chinese. In general, the students agreed that they like to learn…

  2. Image Retrieval: Theoretical Analysis and Empirical User Studies on Accessing Information in Images.

    ERIC Educational Resources Information Center

    Ornager, Susanne

    1997-01-01

    Discusses indexing and retrieval for effective searches of digitized images. Reports on an empirical study about criteria for analysis and indexing digitized images, and the different types of user queries done in newspaper image archives in Denmark. Concludes that it is necessary that the indexing represent both a factual and an expressional…

  3. Requisite Skills of Entry-Level Programmers: An Empirical Study in Brunei Darussalam.

    ERIC Educational Resources Information Center

    Rahman, Mohd Noah A.; Rahim, M. Mahbubur; Seyal, Afzaal H.

    1999-01-01

    Reports the results of an empirical study in Brunei Darussalam that identified the types of skills required for entry-level computer programmers. Investigated whether skills were related to organizational size; determined that communications skills were the top requirement, followed by database management systems skills; and discovered a decline…

  4. What Children Need: Cooperative Religious Education in German Schools--Results from an Empirical Study

    ERIC Educational Resources Information Center

    Schweitzer, Friedrich; Boschki, Reinhold

    2004-01-01

    This article gives a report on a recent empirical study on cooperative religious education in German primary schools. Special emphasis is given to the views, needs, and rights of children. Results from interviews with the children and with the teachers as well as from classroom observation form the basis for the authors' suggestions concerning the…

  5. An Empirical Case Study of a Child Sexual Abuse Prevention Initiative in Georgia

    ERIC Educational Resources Information Center

    Schober, Daniel J.; Fawcett, Stephen B.; Thigpen, Sally; Curtis, Anna; Wright, Renee

    2012-01-01

    Objective: This empirical case study describes Prevent Child Abuse Georgia's effort to prevent child sexual abuse (CSA) by educating communities throughout the state on supporting preventive behaviour. The initiative consisted of three major components: (1) dissemination of CSA prevention messages and materials; (2) a statewide helpline that…

  6. Is Sustainability Possible? A Review and Commentary on Empirical Studies of Program Sustainability

    ERIC Educational Resources Information Center

    Scheirer, Mary Ann

    2005-01-01

    An important final step in the life cycles of programs and their evaluation involves assessing new programs' or innovations' sustainability. This review and synthesis of 19 empirical studies of the sustainability of American and Canadian health-related programs examines the extent of sustainability achieved and summarizes factors contributing to…

  7. Model Selection for Equating Testlet-Based Tests in the NEAT Design: An Empirical Study

    ERIC Educational Resources Information Center

    He, Wei; Li, Feifei; Wolfe, Edward W.; Mao, Xia

    2012-01-01

    For those tests solely composed of testlets, local item independency assumption tends to be violated. This study, by using empirical data from a large-scale state assessment program, was interested in investigates the effects of using different models on equating results under the non-equivalent group anchor-test (NEAT) design. Specifically, the…

  8. An Empirical Study of the Application of Psychological Principles to the Teaching of Orienteering.

    ERIC Educational Resources Information Center

    Martland, J. R.

    1983-01-01

    An empirical study was carried out to explore effects of three sets of schedules developed by Edgar Stones as guidelines conducive to student learning. Guidelines for concept teaching, psychomotor skill development, and teaching problem solving formed the instructional framework for teaching 11-year-old children the principles of navigational…

  9. University-Industry Collaboration, Knowledge Management and Enterprise Innovation Performance: An Empirical Study

    ERIC Educational Resources Information Center

    Chen, Jin; Wei, Shiyang

    2008-01-01

    This empirical study is concerned with university-industry collaboration from a knowledge management perspective. The authors introduce the concepts of "enterprise-level core elements" to define the principle status of an enterprise during university-industry collaboration, and "network embeddedness" as an indication of the…

  10. Chinese Students' Psychological and Sociocultural Adjustments to Britain: An Empirical Study

    ERIC Educational Resources Information Center

    Spencer-Oatey, Helen; Xiong, Zhaoning

    2006-01-01

    This paper reports an empirical study of the psychological and sociocultural adjustments of two cohorts of Chinese students taking a foundation course in English language at a British university. Using Zung's (1965) Self-Rating Depression Scale and a modification of Ward and Kennedy's (1999) Sociocultural Adaptation Scale, quantitative data were…

  11. An Empirical Study on the Acquisition of English Rising Tone by Chinese EFL Learners

    ERIC Educational Resources Information Center

    Chen, Wenkai

    2013-01-01

    Intonation is the melody and soul of speech, and plays an important role in oral communication. Nevertheless, the acquisition of English intonation by Chinese EFL learners is far from being satisfactory. It is found by empirical study that the main problems existing in acquiring English rising tone are improper placement of nucleus stress, failure…

  12. Characteristics of Children of Alcoholics--A Review of Empirical Studies.

    ERIC Educational Resources Information Center

    Poston, Vin

    Although it has been estimated that 28,000,000 Americans may be children of alcoholics, these individuals have only recently been given serious attention by researchers and clinicians. Empirical studies pertaining to the effects of having alcoholic parents were reviewed and several clusters of characteristics were derived from the findings: (1)…

  13. Analogical Scaffolding and the Learning of Abstract Ideas in Physics: Empirical Studies

    ERIC Educational Resources Information Center

    Podolefsky, Noah S.; Finkelstein, Noah D.

    2007-01-01

    Previously, we proposed a model of student reasoning which combines the roles of representation, analogy, and layering of meaning--analogical scaffolding [Podolefsky and Finkelstein, Phys. Rev. ST Phys. Educ. Res. 3, 010109 (2007)]. The present empirical studies build on this model to examine its utility and demonstrate the vital intertwining of…

  14. Results from an Empirical Study of School Principals' Decisions about Disclosure of HIV Status

    ERIC Educational Resources Information Center

    Chenneville, Tiffany

    2007-01-01

    Elementary school principals' decisions about disclosure of school age children's confidential medical information was empirically studied. Participants included a stratified sample of 339 elementary school principals from the seven largest school districts in Florida. Each participant received one of six vignettes describing a student with HIV,…

  15. College Education and Attitudes toward Democracy in China: An Empirical Study

    ERIC Educational Resources Information Center

    Wang, Gang; Wu, Liyun; Han, Rongbin

    2015-01-01

    The modernization theory contends that there is a link between education and democracy. Yet few empirical studies have been done to investigate the role of higher education on promoting democratic values in the Chinese context. Using China General Social Survey 2006, this paper generates several findings which are not completely consistent with…

  16. Performance-Based Service Quality Model: An Empirical Study on Japanese Universities

    ERIC Educational Resources Information Center

    Sultan, Parves; Wong, Ho

    2010-01-01

    Purpose: This paper aims to develop and empirically test the performance-based higher education service quality model. Design/methodology/approach: The study develops 67-item instrument for measuring performance-based service quality with a particular focus on the higher education sector. Scale reliability is confirmed using the Cronbach's alpha.…

  17. An Empirical Review of Research Methodologies and Methods in Creativity Studies (2003-2012)

    ERIC Educational Resources Information Center

    Long, Haiying

    2014-01-01

    Based on the data collected from 5 prestigious creativity journals, research methodologies and methods of 612 empirical studies on creativity, published between 2003 and 2012, were reviewed and compared to those in gifted education. Major findings included: (a) Creativity research was predominantly quantitative and psychometrics and experiment…

  18. Has Portfolio Assessment Become Common Practice in EFL Classrooms? Empirical Studies from China

    ERIC Educational Resources Information Center

    Zhang, Shumei

    2009-01-01

    This paper describes the results of an investigation into the use of portfolio assessment (PA) in Chinese context, beginning with a survey of the rationale for the use of portfolios with students. Then the empirical study is presented and the teachers' and the students' as well as the English teaching advisors' voices are revealed through excerpts…

  19. Understanding Transactional Distance in Web-Based Learning Environments: An Empirical Study

    ERIC Educational Resources Information Center

    Huang, Xiaoxia; Chandra, Aruna; DePaolo, Concetta A.; Simmons, Lakisha L.

    2016-01-01

    Transactional distance is an important pedagogical theory in distance education that calls for more empirical support. The purpose of this study was to verify the theory by operationalizing and examining the relationship of (1) dialogue, structure and learner autonomy to transactional distance, and (2) environmental factors and learner demographic…

  20. A Study of Service-Learning at Virginia Highlands Community College and Mountain Empire Community College.

    ERIC Educational Resources Information Center

    Hughes, Alice

    This qualitative study was conducted to explore student perceptions of service learning as well as the importance of service learning to community college students. Data were collected through interviews with 24 community college participants from Virginia Highlands Community College and Mountain Empire Community College, both in southwest…

  1. Fosfomycin tromethamine in uncomplicated urinary tract infections: a clinical study.

    PubMed

    Bonfiglio, Giovanni; Mattina, Roberto; Lanzafame, Antonina; Cammarata, Esmeralda; Tempera, Gianna

    2005-05-01

    The aim of our study was to verify if the empiric therapy with a single dose of 3 g fosfomycin tromethamine in patients with uncomplicated urinary tract infections (UTIs) was able to clinically resolveand to microbiologically eradicate the infection. A total of 387 out of the 400 patients (274 cases with acute and 113 cases with recurrent uncomplicated UTIs) were enrolled in the clinical study. Clinical and microbiological assessments were performed before and at 8-10 days after the administration. At follow-up high clinical recovery (88.9%) and bacteriological (94.9%) eradication rates were achieved. Gastrointestinal side effects were found in only 4.3% of patients. In conclusion, a single-dose administration regimen of fosfomycin tromethamine should be encouraged as a first choice of drug therapy for uncomplicated UTIs.

  2. An empirical evaluation of devolving administrative control to Costa Rican hospital and clinic directors.

    PubMed

    Lee, Theodore; McKee, Douglas

    2015-01-01

    In the early 2000s, Costa Rica implemented comprehensive reforms of its health care system, including devolving administrative power from the central government to some providers that remain part of the national system. In this article, we evaluate how this aspect of the reform affected clinic efficiency and population health by analyzing administrative data on regional providers and mortality rates in local areas. We compare changes in outcomes across time between areas that signed performance contracts with the central government and received limited budgetary control to those that continued to be managed directly by the central government. We believe the reform created opportunities for providers to become more efficient and effective. Our results suggest that the reform significantly decreased costs without adversely affecting quality of care or population health.

  3. The Ease of Language Understanding (ELU) model: theoretical, empirical, and clinical advances

    PubMed Central

    Rönnberg, Jerker; Lunner, Thomas; Zekveld, Adriana; Sörqvist, Patrik; Danielsson, Henrik; Lyxell, Björn; Dahlström, Örjan; Signoret, Carine; Stenfelt, Stefan; Pichora-Fuller, M. Kathleen; Rudner, Mary

    2013-01-01

    Working memory is important for online language processing during conversation. We use it to maintain relevant information, to inhibit or ignore irrelevant information, and to attend to conversation selectively. Working memory helps us to keep track of and actively participate in conversation, including taking turns and following the gist. This paper examines the Ease of Language Understanding model (i.e., the ELU model, Rönnberg, 2003; Rönnberg et al., 2008) in light of new behavioral and neural findings concerning the role of working memory capacity (WMC) in uni-modal and bimodal language processing. The new ELU model is a meaning prediction system that depends on phonological and semantic interactions in rapid implicit and slower explicit processing mechanisms that both depend on WMC albeit in different ways. It is based on findings that address the relationship between WMC and (a) early attention processes in listening to speech, (b) signal processing in hearing aids and its effects on short-term memory, (c) inhibition of speech maskers and its effect on episodic long-term memory, (d) the effects of hearing impairment on episodic and semantic long-term memory, and finally, (e) listening effort. New predictions and clinical implications are outlined. Comparisons with other WMC and speech perception models are made. PMID:23874273

  4. Effects of the performance management information system in improving performance: an empirical study in Shanghai Ninth People's Hospital.

    PubMed

    Cui, Yinghui; Wu, Zhengyi; Lu, Yao; Jin, Wenzhong; Dai, Xing; Bai, Jinxi

    2016-01-01

    Improving the performance of clinical departments is not only the significant content of the healthcare system reform in China, but also the essential approach to better satisfying the Chinese growing demand for medical services. Performance management is vital and meaningful to public hospitals in China. Several studies are conducted in hospital internal performance management, but almost none of them consider the effects of informational tools. Therefore, we carried out an empirical study on effects of using performance management information system in Shanghai Ninth People's Hospital. The main feature of the system is that it provides a real-time query platform for users to analyze and dynamically monitor the key performance indexes, timely detect problems and make adjustments. We collected pivotal medical data on 35 clinical departments of this hospital from January 2013 until December 2014, 1 year before and after applying the performance management information system. Comparative analysis was conducted by statistical methods. The results show that the system is beneficial to improve performance scores of clinical departments and lower the proportion of drug expenses, meanwhile, shorten the average hospitalized days and increase the bed turnover rate. That is to say, with the increasing medical services, the quality and efficiency is greatly improved. In a word, application of the performance management information system has a positive effect on improving performance of clinical departments.

  5. Clinical Predictors and Accuracy of Empiric Tuberculosis Treatment among Sputum Smear-Negative HIV-Infected Adult TB Suspects in Uganda

    PubMed Central

    Nakiyingi, Lydia; Bwanika, John Mark; Kirenga, Bruce; Nakanjako, Damalie; Katabira, Catherine; Lubega, Gloria; Sempa, Joseph; Nyesiga, Barnabas; Albert, Heidi; Manabe, Yukari C.

    2013-01-01

    Introduction The existing diagnostic algorithms for sputum smear-negative tuberculosis (TB) are complicated, time-consuming, and often difficult to implement. The decision to initiate TB treatment in resource-limited countries is often largely based on clinical predictors. We sought to determine the clinical predictors and accuracy of empiric TB treatment initiation in HIV-infected sputum smear-negative TB suspects using sputum culture as a reference standard. Setting Out-patient HIV-TB integrated urban clinic in Kampala, Uganda. Methods HIV-infected TB suspects were screened using sputum smear microscopy, and mycobacterial sputum liquid and solid cultures were performed. Smear results were made available to the clinician who made a clinical decision on empiric TB treatment initiation for sputum smear-negative patients. Clinic records were reviewed for patients whose sputum smears were negative to collect data on socio-demographics, TB symptomatology, chest X-ray findings, CD4 cell counts and TB treatment initiation. Results Of 253 smear-negative TB suspects, 56% (142/253) were females, median age 38 IQR (31–44) years, with a median CD4 cell count of 291 IQR (150–482) cells/mm3. Of the 85 (33.6%) smear-negative patients empirically initiated on TB treatment, 35.3% (n = 30) were sputum culture positive compared to only 18 (10.7%) of the 168 untreated patients (p<0.001). Abnormal chest X-ray [aOR 10.18, 95% CI (3.14–33.00), p<0.001] and advanced HIV clinical stage [aOR 3.92, 95% CI (1.20–12.85), p = 0.024] were significantly associated with empiric TB treatment initiation. The sensitivity and specificity of empiric TB treatment initiation in the diagnosis of TB in HIV-infected patients after negative smear microscopy was 62.5% and 73.7% respectively. Conclusion In resource-limited settings, clinically advanced HIV and abnormal chest X-ray significantly predict a clinical decision to empirically initiate TB treatment in smear-negative HIV

  6. Empirically Derived Subtypes of Lifetime Anxiety Disorders: Developmental and Clinical Correlates in U.S. Adolescents

    ERIC Educational Resources Information Center

    Burstein, Marcy; Georgiades, Katholiki; Lamers, Femke; Swanson, Sonja A.; Cui, Lihong; He, Jian-Ping; Avenevoli, Shelli; Merikangas, Kathleen R.

    2012-01-01

    Objective: The current study examined the sex- and age-specific structure and comorbidity of lifetime anxiety disorders among U.S. adolescents. Method: The sample consisted of 2,539 adolescents (1,505 females and 1,034 males) from the National Comorbidity Survey-Adolescent Supplement who met criteria for "Diagnostic and Statistical Manual of…

  7. Prevalence of Clinically and Empirically Defined Talents and Strengths in Autism

    ERIC Educational Resources Information Center

    Meilleur, Andrée-Anne S.; Jelenic, Patricia; Mottron, Laurent

    2015-01-01

    Outstanding skills, including special isolated skills (SIS) and perceptual peaks (PP) are frequent features of autism. However, their reported prevalence varies between studies and their co-occurrence is unknown. We determined the prevalence of SIS in a large group of 254 autistic individuals and searched for PP in 46 of these autistic individuals…

  8. Development of phonological awareness in Down syndrome: A meta-analysis and empirical study.

    PubMed

    Næss, Kari-Anne B

    2016-02-01

    Phonological awareness (PA) is the knowledge and understanding of the sound structure of language and is believed to be an important skill for the development of reading. This study explored PA skills in children with Down syndrome and matched typically developing (TD) controls using a dual approach: a meta-analysis of the existing international literature and a longitudinal empirical study. The results from both the meta-analysis and the empirical study showed that the children with Down syndrome initially had weaker PA skills compared to the controls; in particular, the awareness of rhyme was delayed. The longitudinal empirical data indicated that, as a result of formal education, the children with Down syndrome exhibited greater improvement on all PA measures compared with the controls who had not yet entered school. The results reach significance for rhyme awareness. With respect to dimensionality, the performance of the children with Down syndrome loaded on 1 factor, whereas the performance of the younger TD controls was multidimensional. In sum, these findings underline the need for studies that compare interventions designed especially to stimulate development of PA in this group of children and to provide insight into the underlying causes of the developmental profile of children with Down syndrome.

  9. [Clinical studies in developing countries].

    PubMed

    van den Munkhof, Hanna E

    2013-01-01

    In general, clinical trials in developing countries are met with resistance because the people are particularly vulnerable and medical assistance is often unaffordable. The prospect of free medication can then lead to exploitation since the local population can be persuaded to participate in trials that would never be allowed in Western countries due to ethical concerns. Placebo-controlled research that tests cheaper alternatives for treatments already registered could greatly improve the situation in developing countries, however. Expensive registered treatments are often unavailable in these countries. Therefore, I call for allowing such studies when the registered treatment is locally unavailable. This should be based on the four most important principles of medical ethics: the duty to help patients, avoid harm, justice and respect for autonomy. On the condition, however, that the population in developing countries benefits in the long term.

  10. Inter-firm Networks, Organizational Learning and Knowledge Updating: An Empirical Study

    NASA Astrophysics Data System (ADS)

    Zhang, Su-rong; Wang, Wen-ping

    In the era of knowledge-based economy which information technology develops rapidly, the rate of knowledge updating has become a critical factor for enterprises to gaining competitive advantage .We build an interactional theoretical model among inter-firm networks, organizational learning and knowledge updating thereby and demonstrate it with empirical study at last. The result shows that inter-firm networks and organizational learning is the source of knowledge updating.

  11. Hyperventilation in Panic Disorder and Asthma: Empirical Evidence and Clinical Strategies

    PubMed Central

    Meuret, Alicia E.; Ritz, Thomas

    2010-01-01

    Sustained or spontaneous hyperventilation has been associated with a variety of physical symptoms and has been linked to a number of organic illnesses and mental disorders. Theories of panic disorder hold that hyperventilation either produces feared symptoms of hypocapnia or protects against feared suffocation symptoms of hypercapnia. Although the evidence for both theories is inconclusive, findings from observational, experimental, and therapeutic studies suggest an important role of low carbon dioxide (CO2) levels in this disorder. Similarly, hypocapnia and associated hyperpnia are linked to bronchoconstriction, symptom exacerbation, and lower quality of life in patients with asthma. Raising CO2 levels by means of therapeutic capnometry has proven beneficial effects in both disorders, and the reversing of hyperventilation has emerged as a potent mediator for reductions in panic symptom severity and treatment success. PMID:20685222

  12. Empirical studies on environmental education in Germany: Contributions by the institute for science education

    NASA Astrophysics Data System (ADS)

    Dempsey, Rachael; Gresele, Christiane; Bögeholz, Susanne; Martens, Thomas; Mayer, Jürgen; Rode, Horst; Rost, Jürgen

    1998-06-01

    The Institute for Science Education (IPN) in Kiel, Germany, has a long tradition in environmental education research, material and instruction development, and teacher education. This paper presents its research program on “Factors of Environmental Activity” consisting, at present, of three empirical research studies. These projects share a common theoretical model, the Integrated Action Model, describing the environmental action generating process. Study 1 evaluates the validity of this model; Study 2 applies it to evaluate the effects of school environmental instruction; Study 3 applies it to evaluate the effects of nature experience. As this research pertains to Germany, a description of the school system and institutionalisation of environmental instruction is included.

  13. Effects of Mindfulness on Psychological Health: A Review of Empirical Studies

    PubMed Central

    Keng, Shian-Ling; Smoski, Moria J.; Robins, Clive J.

    2013-01-01

    Within the past few decades, there has been a surge of interest in the investigation of mindfulness as a psychological construct and as a form of clinical intervention. This article reviews the empirical literature on the effects of mindfulness on psychological health. We begin with a discussion of the construct of mindfulness, differences between Buddhist and Western psychological conceptualizations of mindfulness, and how mindfulness has been integrated into Western medicine and psychology, before reviewing three areas of empirical research: cross-sectional, correlational research on the associations between mindfulness and various indicators of psychological health; intervention research on the effects of mindfulness-oriented interventions on psychological health; and laboratory-based, experimental research on the immediate effects of mindfulness inductions on emotional and behavioral functioning. We conclude that mindfulness brings about various positive psychological effects, including increased subjective well-being, reduced psychological symptoms and emotional reactivity, and improved behavioral regulation. The review ends with a discussion on mechanisms of change of mindfulness interventions and suggested directions for future research. PMID:21802619

  14. Effects of mindfulness on psychological health: a review of empirical studies.

    PubMed

    Keng, Shian-Ling; Smoski, Moria J; Robins, Clive J

    2011-08-01

    Within the past few decades, there has been a surge of interest in the investigation of mindfulness as a psychological construct and as a form of clinical intervention. This article reviews the empirical literature on the effects of mindfulness on psychological health. We begin with a discussion of the construct of mindfulness, differences between Buddhist and Western psychological conceptualizations of mindfulness, and how mindfulness has been integrated into Western medicine and psychology, before reviewing three areas of empirical research: cross-sectional, correlational research on the associations between mindfulness and various indicators of psychological health; intervention research on the effects of mindfulness-oriented interventions on psychological health; and laboratory-based, experimental research on the immediate effects of mindfulness inductions on emotional and behavioral functioning. We conclude that mindfulness brings about various positive psychological effects, including increased subjective well-being, reduced psychological symptoms and emotional reactivity, and improved behavioral regulation. The review ends with a discussion on mechanisms of change of mindfulness interventions and suggested directions for future research.

  15. Evaluating Process Quality Based on Change Request Data - An Empirical Study of the Eclipse Project

    NASA Astrophysics Data System (ADS)

    Schackmann, Holger; Schaefer, Henning; Lichter, Horst

    The information routinely collected in change request management systems contains valuable information for monitoring of the process quality. However this data is currently utilized in a very limited way. This paper presents an empirical study of the process quality in the product portfolio of the Eclipse project. It is based on a systematic approach for the evaluation of process quality characteristics using change request data. Results of the study offer insights into the development process of Eclipse. Moreover the study allows assessing applicability and limitations of the proposed approach for the evaluation of process quality.

  16. Empirical Bayes scan statistics for detecting clusters of disease risk variants in genetic studies.

    PubMed

    McCallum, Kenneth J; Ionita-Laza, Iuliana

    2015-12-01

    Recent developments of high-throughput genomic technologies offer an unprecedented detailed view of the genetic variation in various human populations, and promise to lead to significant progress in understanding the genetic basis of complex diseases. Despite this tremendous advance in data generation, it remains very challenging to analyze and interpret these data due to their sparse and high-dimensional nature. Here, we propose novel applications and new developments of empirical Bayes scan statistics to identify genomic regions significantly enriched with disease risk variants. We show that the proposed empirical Bayes methodology can be substantially more powerful than existing scan statistics methods especially so in the presence of many non-disease risk variants, and in situations when there is a mixture of risk and protective variants. Furthermore, the empirical Bayes approach has greater flexibility to accommodate covariates such as functional prediction scores and additional biomarkers. As proof-of-concept we apply the proposed methods to a whole-exome sequencing study for autism spectrum disorders and identify several promising candidate genes.

  17. Scaling up explanation generation: Large-scale knowledge bases and empirical studies

    SciTech Connect

    Lester, J.C.; Porter, B.W.

    1996-12-31

    To explain complex phenomena, an explanation system must be able to select information from a formal representation of domain knowledge, organize the selected information into multisentential discourse plans, and realize the discourse plans in text. Although recent years have witnessed significant progress in the development of sophisticated computational mechanisms for explanation, empirical results have been limited. This paper reports on a seven year effort to empirically study explanation generation from semantically rich, large-scale knowledge bases. We first describe Knight, a robust explanation system that constructs multi-sentential and multi-paragraph explanations from the Biology Knowledge Base, a large-scale knowledge base in the domain of botanical anatomy, physiology, and development. We then introduce the Two Panel evaluation methodology and describe how Knight`s performance was assessed with this methodology in the most extensive empirical evaluation conducted on an explanation system. In this evaluation, Knight scored within {open_quotes}half a grade{close_quote} of domain experts, and its performance exceeded that of one of the domain experts.

  18. Evidence for the Effectiveness of Jungian Psychotherapy: A Review of Empirical Studies

    PubMed Central

    Roesler, Christian

    2013-01-01

    Since the 1990s several research projects and empirical studies (process and outcome) on Jungian Psychotherapy have been conducted mainly in Germany and Switzerland. Prospective, naturalistic outcome studies and retrospective studies using standardized instruments and health insurance data as well as several qualitative studies of aspects of the psychotherapeutic process will be summarized. The studies are diligently designed and the results are well applicable to the conditions of outpatient practice. All the studies show significant improvements not only on the level of symptoms and interpersonal problems, but also on the level of personality structure and in every day life conduct. These improvements remain stable after completion of therapy over a period of up to six years. Several studies show further improvements after the end of therapy, an effect which psychoanalysis has always claimed. Health insurance data show that, after Jungian therapy, patients reduce health care utilization to a level even below the average of the total population. Results of several studies show that Jungian treatment moves patients from a level of severe symptoms to a level where one can speak of psychological health. These significant changes are reached by Jungian therapy with an average of 90 sessions, which makes Jungian psychotherapy an effective and cost-effective method. Process studies support Jungian theories on psychodynamics and elements of change in the therapeutic process. So finally, Jungian psychotherapy has reached the point where it can be called an empirically proven, effective method. PMID:25379256

  19. Empirical Research and Geography Teaching. Nederlandse Geografische Studies 142 (Netherlands Geographical Studies 142).

    ERIC Educational Resources Information Center

    Schrettenbrunner, H., Ed.; Westrhenen, J. van, Ed.

    This volume contains 10 articles that concern research efforts undertaken in the field of geography education and training. Written by researchers from around the world, the articles include: (1) "Empirical Didactics of Geography: History of a Working Group" (H. Schrettenbrunner); (2) "The Development and Evaluation of a Geography Computer…

  20. How fast is fisheries-induced evolution? Quantitative analysis of modelling and empirical studies

    PubMed Central

    Audzijonyte, Asta; Kuparinen, Anna; Fulton, Elizabeth A

    2013-01-01

    A number of theoretical models, experimental studies and time-series studies of wild fish have explored the presence and magnitude of fisheries-induced evolution (FIE). While most studies agree that FIE is likely to be happening in many fished stocks, there are disagreements about its rates and implications for stock viability. To address these disagreements in a quantitative manner, we conducted a meta-analysis of FIE rates reported in theoretical and empirical studies. We discovered that rates of phenotypic change observed in wild fish are about four times higher than the evolutionary rates reported in modelling studies, but correlation between the rate of change and instantaneous fishing mortality (F) was very similar in the two types of studies. Mixed-model analyses showed that in the modelling studies traits associated with reproductive investment and growth evolved slower than rates related to maturation. In empirical observations age-at-maturation was changing faster than other life-history traits. We also found that, despite different assumption and modelling approaches, rates of evolution for a given F value reported in 10 of 13 modelling studies were not significantly different. PMID:23789026

  1. Intimate Partner Violence Among Help-Seeking Deaf Women: An Empirical Study.

    PubMed

    Ballan, Michelle S; Freyer, Molly Burke; Powledge, Lauren; Marti, C Nathan

    2016-08-30

    Deaf women face heightened rates of intimate partner violence (IPV) compared with hearing women, yet limited research has focused on IPV among this population. Empirical studies are warranted to examine the unique experiences and resource needs of Deaf women, along with barriers excluding Deaf participants from IPV research and service provision. Our study addresses these gaps by providing a profile of 80 Deaf women attending an IPV program serving individuals with disabilities. Demographic and psychosocial characteristics, referral channels that led women to the program, and services sought post-referral are discussed to help guide best practices with Deaf survivors of IPV.

  2. Integrating technology readiness into the expectation-confirmation model: an empirical study of mobile services.

    PubMed

    Chen, Shih-Chih; Liu, Ming-Ling; Lin, Chieh-Peng

    2013-08-01

    The aim of this study was to integrate technology readiness into the expectation-confirmation model (ECM) for explaining individuals' continuance of mobile data service usage. After reviewing the ECM and technology readiness, an integrated model was demonstrated via empirical data. Compared with the original ECM, the findings of this study show that the integrated model may offer an ameliorated way to clarify what factors and how they influence the continuous intention toward mobile services. Finally, the major findings are summarized, and future research directions are suggested.

  3. An Empirical Study of Plan-Based Representations of Pascal and Fortran Code.

    DTIC Science & Technology

    1987-06-01

    COMPUTING LABORATORY lReport No. CCL-0687-0 00 IAN EMPIRICAL STUDY OF PLAN-BASED REPRESENTATIONS OF PASCAL AND FORTRAN CODE Scott P. Robertson Chiung-Chen Yu...82173 ’, " Office of Naval Research Contract No. N00014-86-K-0876 Work Unit No. NR 4424203-01 APPROVED FOR PUBLIC RELEASE; DISTRIBUTION UNLIMITED...researchers have argued recenitly that programmers utilize a plan-based representation when composing or comprehending program code. In a series of studies we

  4. Combining several ordinal measures in clinical studies.

    PubMed

    Wittkowski, Knut M; Lee, Edmund; Nussbaum, Rachel; Chamian, Francesca N; Krueger, James G

    2004-05-30

    In medical research, it is rare that a single variable is sufficient to represent all relevant aspects of epidemiological risk, genomic activity, adverse events, or clinical response. Since biological systems tend to be neither linear, nor hierarchical in nature, the assumptions of traditional multivariate statistical methods based on the linear model can often not be justified on theoretical grounds. Establishing concept validity through empirical validation is not only problematic, but also time consuming. This paper proposes the use of u-statistics for scoring multivariate ordinal data and a family of simple non-parametric tests for analysis. The scoring method is demonstrated to be applicable to scoring clinical response profiles in the treatment of psoriasis and then to identifying genomic pathways that best correlate with these profiles.

  5. Numerical modeling study into the climatic impact of deforestation associated with the fall of Mayan Empire

    NASA Astrophysics Data System (ADS)

    Kongoli, C.; Nair, U. S.; Welch, R. M.; Sever, T. L.; Irwin, D.; Pielke, R. A.

    2002-05-01

    The collapse the Mayan Empire, which flourished from 250 to 900 AD in the Southern Mexico and Central American regions, is one of the greatest demographic disasters in the human history. Early studies of Mayan civilization found cessation in dating and inscription of monuments in the ninth century. Later studies suggest a two-thirds decline in Mayan population numbering millions between 830 and 900 AD. The reason for this population decline and the subsequent collapse of Mayan Empire in ninth century is not known. The mass exodus of population has been ruled out since the population in the surrounding regions remained stable during this time period. Other suggested reasons for this population decline include conflict, disease, warfare, climate change. However, studies of historical pollen data indicate increased rates of deforestation starting in the fifth century with most of the trees in the region being cut down by the ninth century. Lake core sediments document a major drought around 800 AD that was one of the most intense drought in an 8000 year history. A recent study on climatic reconstruction from pollen records also indicate that climate became drier following the collapse of the Mayan Empire, and suggest that this may be due to the cutting down of trees. In the present study, the effect of forest clearing on the regional climate in the Mayan region is examined using the Colorado State University Regional Atmospheric Modeling System (CSU RAMS). The RAMS is being used to simulate the rainfall over the Mayan region for conditions where the surface is assumed to be completely forested and deforested. Simulations are being done for two months, both in the wet and dry season. Comparison of RAMS simulated rainfall between the completely forested and deforested scenarios are expected to provide bounds on regional climate change brought about by deforestation. Further details will be presented at the conference.

  6. Semi-empirical procedures for correcting detector size effect on clinical MV x-ray beam profiles.

    PubMed

    Sahoo, Narayan; Kazi, Abdul M; Hoffman, Mark

    2008-11-01

    The measured radiation beam profiles need to be corrected for the detector size effect to derive the real profiles. This paper describes two new semi-empirical procedures to determine the real profiles of high-energy x-ray beams by removing the detector size effect from the measured profiles. Measured profiles are corrected by shifting the position of each measurement point by a specific amount determined from available theoretical and experimental knowledge in the literature. The authors developed two procedures to determine the amount of shift. In the first procedure, which employs the published analytical deconvolution procedure of other investigators, the shift is determined from the comparison of the analytical fit of the measured profile and the corresponding analytical real profile derived from the deconvolution of the fitted measured profile and the Gaussian detector response function. In the second procedure, the amount of shift at any measurement point is considered to be proportional to the value of an analytical function related to the second derivative of the real profile at that point. The constant of proportionality and a parameter in the function are obtained from the values of the shifts at the 90%, 80%, 20%, and 10% dose levels, which are experimentally known from the published results of other investigators to be approximately equal to half of the radius of the detector. These procedures were tested by correcting the profiles of 6 and 18 MV x-ray beams measured by three different ionization chambers and a stereotactic field diode detector with 2.75, 2, 1, and 0.3 mm radii of their respective active cylindrical volumes. The corrected profiles measured by different detectors are found to be in close agreement. The detector size corrected penumbra widths also agree with the expected values based on the results of an earlier investigation. Thus, the authors concluded that the proposed procedures are accurate and can be used to derive the real

  7. Now or Later?: An Empirical Investigation of When and Why Students Apply to Clinical Psychology PhD Programs

    ERIC Educational Resources Information Center

    Zimak, Eric H.; Edwards, Katie M.; Johnson, Shannon M.; Suhr, Julie

    2011-01-01

    This study used a national sample of PhD students in clinical psychology (N = 1,034) to explore when students decided to pursue their graduate degree, reasons for their decisions, and associated satisfaction. Results indicated that immediately after completing their undergraduate degree, 57% of current graduate students reported postponing…

  8. Empirical Correlates of Low Scores on MMPI-2/MMPI-2-RF Restructured Clinical Scales in a Sample of University Students

    ERIC Educational Resources Information Center

    Avdeyeva, Tatyana V.; Tellegen, Auke; Ben-Porath, Yossef S.

    2012-01-01

    In the present study, the authors explored the meaning of low scores on the MMPI-2/MMPI-2-RF Restructured Clinical (RC) scales. Using responses of a sample of university students (N = 811), the authors examined whether low (T less than 39), within-normal-limits (T = 39-64), and high (T greater than 65) score levels on the RC scales are…

  9. Linking customisation of ERP systems to support effort: an empirical study

    NASA Astrophysics Data System (ADS)

    Koch, Stefan; Mitteregger, Kurt

    2016-01-01

    The amount of customisation to an enterprise resource planning (ERP) system has always been a major concern in the context of the implementation. This article focuses on the phase of maintenance and presents an empirical study about the relationship between the amount of customising and the resulting support effort. We establish a structural equation modelling model that explains support effort using customisation effort, organisational characteristics and scope of implementation. The findings using data from an ERP provider show that there is a statistically significant effect: with an increasing amount of customisation, the quantity of telephone calls to support increases, as well as the duration of each call.

  10. Does Branding Need Web Usability? A Value-Oriented Empirical Study

    NASA Astrophysics Data System (ADS)

    Bolchini, Davide; Garzotto, Franca; Sorce, Fabio

    Does usability of a web-based communication artifact affect brand, i.e., the set of beliefs, emotions, attitudes, or qualities that people mentally associate to the entity behind that artifact? Intuitively, the answer is “yes”: usability is a fundamental aspect of the quality of the experience with a website, and a “good” experience with a “product” or its reifications tends to translate into “good” brand perception. To date, however, the existence of a connection between web usability and brand perception is shown through anecdotic arguments, and is not supported by published systematic research. This paper discusses a study that empirically investigates this correlation in a more rigorous, analytical, and replicable way. Our main contribution is twofold: on the one hand, we provide empirical evidence to the heuristic principle that web usability influences branding, and we do that through four between subjects controlled experiments that involved 120 subjects. On the other hand, we inform the study with a systematic value-oriented approach to the user experience, and thus provide a conceptual framework that can be reused in other experimental settings, either for replicating our study, or for designing similar studies focusing on the correlation of web branding vs. design factors other than usability.

  11. Managing the Services Supply Chain in the Department of Defense: Empirical Study of the Current Management Practices in the Army

    DTIC Science & Technology

    2009-09-21

    Managing the Services Supply Chain in the Department of Defense: Empirical Study of the Current Management Practices in the Army 21 September...Managing the Services Supply Chain in the Department of Defense: Empirical Study of the Current Management Practices in the Army 5a. CONTRACT NUMBER 5b...Service Supply Chain , Services Acquisition, Service Lifecycle, Contract Management, Project Management, Program Management = = ^Åèìáëáíáçå=oÉëÉ~êÅÜ

  12. Evaluation research in occupational health services: general principles and a systematic review of empirical studies

    PubMed Central

    Hulshof, C. T.; Verbeek, J. H.; van Dijk, F. J.; van der Weide, W. E.; Braam, I. T.

    1999-01-01

    OBJECTIVES: To study the nature and extent of evaluation research in occupational health services (OHSs). METHODS: Literature review of evaluation research in OHSs. On the basis of a conceptual model of OHS evaluation, empirical studies are categorised into aspects of input, process, output, outcome, and OHS core activities. RESULTS: Many methods to evaluate OHSs or OHS activities exist, depending on the objective and object of evaluation. The amount of empirical studies on evaluation of OHSs or OHS activities that met the non-restrictive inclusion criteria, was remarkably limited. Most of the 52 studies were more descriptive than evaluative. The methodological quality of most studies was not high. A differentiated picture of the evidence of effectiveness of OHSs arises. Occupational health consultations and occupational rehabilitation are hardly studied despite much time spent on the consultation by occupational physicians in most countries. The lack of effectiveness and efficiency of the pre-employment examination should lead to its abandonment as a means of selection of personnel by OHSs. Periodic health monitoring or surveillance, and education on occupational health hazards can be carried out with reasonable process quality. Identification and evaluation of occupational health hazards by a workplace survey can be done with a high output quality, which, however, does not guarantee a favourable outcome. CONCLUSIONS: Although rigorous study designs are not always applicable or feasible in daily practice, much more effort should be directed at the scientific evaluation of OHSs and OHS instruments. To develop evidence-based occupational health care the quality of evaluation studies should be improved. In particular, process and outcome of consultation and rehabilitation activities of occupational physicians need to be studied more.   PMID:10474531

  13. Empirical studies on usability of mHealth apps: a systematic literature review.

    PubMed

    Zapata, Belén Cruz; Fernández-Alemán, José Luis; Idri, Ali; Toval, Ambrosio

    2015-02-01

    The release of smartphones and tablets, which offer more advanced communication and computing capabilities, has led to the strong emergence of mHealth on the market. mHealth systems are being used to improve patients' lives and their health, in addition to facilitating communication between doctors and patients. Researchers are now proposing mHealth applications for many health conditions such as dementia, autism, dysarthria, Parkinson's disease, and so on. Usability becomes a key factor in the adoption of these applications, which are often used by people who have problems when using mobile devices and who have a limited experience of technology. The aim of this paper is to investigate the empirical usability evaluation processes described in a total of 22 selected studies related to mHealth applications by means of a Systematic Literature Review. Our results show that the empirical evaluation methods employed as regards usability could be improved by the adoption of automated mechanisms. The evaluation processes should also be revised to combine more than one method. This paper will help researchers and developers to create more usable applications. Our study demonstrates the importance of adapting health applications to users' need.

  14. Reliable Crack Detection in Turbine Blades Using Thermosonics: AN Empirical Study

    NASA Astrophysics Data System (ADS)

    Bolu, G.; Gachagan, A.; Pierce, G.; Harvey, G.

    2010-02-01

    Excitation generated by ultrasonic horns typically used in thermosonics (or Sonic IR) is non-reproducible, raising concerns that cracks in some locations can be missed. This paper presents an empirical study on the thermosonic inspection of turbine blades. The objective is to assess the reliability of thermosonics as an NDT screening method for findings crack in turbine blades. First, a study was carried out to establish the operating parameters that generated the highest possible temperature rise from a crack. Next, a repeatability study was conducted to measure consistency of results in 300 tests, which showed 100% repeatability. Finally, 60 cracked blades were inspected, with the known cracks in 57 blades detected. These results show the potential of thermosonics as a reliable NDT screening method for finding cracks in turbine blades.

  15. Decomposition approach of the nitrogen generation process: empirical study on the Shimabara Peninsula in Japan.

    PubMed

    Fujii, Hidemichi; Nakagawa, Kei; Kagabu, Makoto

    2016-11-01

    Groundwater nitrate pollution is one of the most prevalent water-related environmental problems worldwide. The objective of this study is to identify the determinants of nitrogen pollutant changes with a focus on the nitrogen generation process. The novelty of our research framework is to cost-effectively identify the factors involved in nitrogen pollutant generation using public data. This study focuses on three determinant factors: (1) nitrogen intensity changes, (2) structural changes, and (3) scale changes. This study empirically analyses three sectors, including crop production, farm animals, and the household, on the Shimabara Peninsula in Japan. Our results show that the nitrogen supply from crop production sectors has decreased because the production has been scaled down and shifted towards lower nitrogen intensive crops. In the farm animal sector, the nitrogen supply has also been successfully reduced due to scaling-down efforts. Households have decreased the nitrogen supply by diffusion of integrated septic tank and sewerage systems.

  16. Simulation during observation of human actions--theories, empirical studies, applications.

    PubMed

    Zentgraf, Karen; Munzert, Jörn; Bischoff, Matthias; Newman-Norlund, Roger D

    2011-04-22

    Historically, data from brain imaging and brain stimulation studies have supported the idea that the processing of observed actions recruits - among other areas - a distinct sub-set of brain sites in the sensory and motor cortices. These empirical findings have initially been linked with the thesis of direct matching as a mechanism of action understanding, i.e., the idea of motor resonance implemented by mirror neurons. In more recent approaches, it has been proposed that the mirror neuron system plays a role in minimizing prediction error when inferring the most likely cause of an observed action. According to these theories, motor resonance is thought to function as predictive coding. Other theoretical accounts suggest that action understanding might result from a hypothesis testing mechanism in which potential goals are continually fed into the system until the correct one is identified. In this review, we will explore the relationship of these theories to specific empirical findings. Finally, we will discuss the implications of these theoretical structures on action observation-based approaches to the optimization of skilled performance in athletes and patients.

  17. An Empirical Study of Synchrophasor Communication Delay in a Utility TCP/IP Network

    NASA Astrophysics Data System (ADS)

    Zhu, Kun; Chenine, Moustafa; Nordström, Lars; Holmström, Sture; Ericsson, Göran

    2013-07-01

    Although there is a plethora of literature dealing with Phasor Measurement Unit (PMU) communication delay, there has not been any effort made to generalize empirical delay results by identifying the distribution with the best fit. The existing studies typically assume a distribution or simply build on analogies to communication network routing delay. Specifically, this study provides insight into the characterization of the communication delay of both unprocessed PMU data and synchrophasors sorted by a Phasor Data Concentrator (PDC). The results suggest that a bi-modal distribution containing two normal distributions offers the best fit of the delay of the unprocessed data, whereas the delay profile of the sorted synchrophasors resembles a normal distribution based on these results, the possibility of evaluating the reliability of a synchrophasor application with respect to a particular choice of PDC timeout is discussed.

  18. The relationship between corporate environmental performance and environmental disclosure: an empirical study in China.

    PubMed

    Meng, X H; Zeng, S X; Shi, Jonathan J; Qi, G Y; Zhang, Z B

    2014-12-01

    Based on a content analysis of 533 Chinese listed companies, this study examines how corporate environmental performance affects not only the level of detail of a company's environmental disclosures, but also what information is disclosed. The results show that (1) both poor and good performers have more disclosure than the median (i.e., "mixed") performers, which provides empirical evidence to support a nonlinear relationship between corporate environmental performance and environmental disclosure; (2) poor performers disclose more soft information on environmental performance than good performers, and good performers disclose more solid information; and (3) although poor performers increase disclosure after being exposed as environmental violators, they avoid disclosing negative environmental information, such as the violation and the associated penalties. This study provides additional evidence for a nonlinear relationship between environmental performance and disclosure in emerging markets, and suggests environmental disclosure may not be a valid signal to differentiate good performers from poor performers in contemporary China.

  19. Anterior temporal face patches: a meta-analysis and empirical study.

    PubMed

    Von Der Heide, Rebecca J; Skipper, Laura M; Olson, Ingrid R

    2013-01-01

    Evidence suggests the anterior temporal lobe (ATL) plays an important role in person identification and memory. In humans, neuroimaging studies of person memory report consistent activations in the ATL to famous and personally familiar faces and studies of patients report resection or damage of the ATL causes an associative prosopagnosia in which face perception is intact but face memory is compromised. In addition, high-resolution fMRI studies of non-human primates and electrophysiological studies of humans also suggest regions of the ventral ATL are sensitive to novel faces. The current study extends previous findings by investigating whether similar subregions in the dorsal, ventral, lateral, or polar aspects of the ATL are sensitive to personally familiar, famous, and novel faces. We present the results of two studies of person memory: a meta-analysis of existing fMRI studies and an empirical fMRI study using optimized imaging parameters. Both studies showed left-lateralized ATL activations to familiar individuals while novel faces activated the right ATL. Activations to famous faces were quite ventral, similar to what has been reported in previous high-resolution fMRI studies of non-human primates. These findings suggest that face memory-sensitive patches in the human ATL are in the ventral/polar ATL.

  20. Anterior temporal face patches: a meta-analysis and empirical study

    PubMed Central

    Von Der Heide, Rebecca J.; Skipper, Laura M.; Olson, Ingrid R.

    2013-01-01

    Evidence suggests the anterior temporal lobe (ATL) plays an important role in person identification and memory. In humans, neuroimaging studies of person memory report consistent activations in the ATL to famous and personally familiar faces and studies of patients report resection or damage of the ATL causes an associative prosopagnosia in which face perception is intact but face memory is compromised. In addition, high-resolution fMRI studies of non-human primates and electrophysiological studies of humans also suggest regions of the ventral ATL are sensitive to novel faces. The current study extends previous findings by investigating whether similar subregions in the dorsal, ventral, lateral, or polar aspects of the ATL are sensitive to personally familiar, famous, and novel faces. We present the results of two studies of person memory: a meta-analysis of existing fMRI studies and an empirical fMRI study using optimized imaging parameters. Both studies showed left-lateralized ATL activations to familiar individuals while novel faces activated the right ATL. Activations to famous faces were quite ventral, similar to what has been reported in previous high-resolution fMRI studies of non-human primates. These findings suggest that face memory-sensitive patches in the human ATL are in the ventral/polar ATL. PMID:23378834

  1. Empirically Derived Combinations of Tools and Clinical Cutoffs: An Illustrative Case with a Sample of Culturally/Linguistically Diverse Children

    ERIC Educational Resources Information Center

    Oetting, Janna B.; Cleveland, Lesli H.; Cope, Robert F., III

    2008-01-01

    Purpose: Using a sample of culturally/linguistically diverse children, we present data to illustrate the value of empirically derived combinations of tools and cutoffs for determining eligibility in child language impairment. Method: Data were from 95 4- and 6-year-olds (40 African American, 55 White; 18 with language impairment, 77 without) who…

  2. Incorporating Functional Genomic Information in Genetic Association Studies Using an Empirical Bayes Approach

    PubMed Central

    Spencer, Amy V.; Cox, Angela; Lin, Wei‐Yu; Easton, Douglas F.; Michailidou, Kyriaki

    2016-01-01

    ABSTRACT There is a large amount of functional genetic data available, which can be used to inform fine‐mapping association studies (in diseases with well‐characterised disease pathways). Single nucleotide polymorphism (SNP) prioritization via Bayes factors is attractive because prior information can inform the effect size or the prior probability of causal association. This approach requires the specification of the effect size. If the information needed to estimate a priori the probability density for the effect sizes for causal SNPs in a genomic region isn't consistent or isn't available, then specifying a prior variance for the effect sizes is challenging. We propose both an empirical method to estimate this prior variance, and a coherent approach to using SNP‐level functional data, to inform the prior probability of causal association. Through simulation we show that when ranking SNPs by our empirical Bayes factor in a fine‐mapping study, the causal SNP rank is generally as high or higher than the rank using Bayes factors with other plausible values of the prior variance. Importantly, we also show that assigning SNP‐specific prior probabilities of association based on expert prior functional knowledge of the disease mechanism can lead to improved causal SNPs ranks compared to ranking with identical prior probabilities of association. We demonstrate the use of our methods by applying the methods to the fine mapping of the CASP8 region of chromosome 2 using genotype data from the Collaborative Oncological Gene‐Environment Study (COGS) Consortium. The data we analysed included approximately 46,000 breast cancer case and 43,000 healthy control samples. PMID:26833494

  3. Personal influences on professional work: an empirical case study of B.F. Skinner.

    PubMed

    Demorest, A P; Siegel, P F

    1996-03-01

    This study addresses the hypothesis that individuals have characteristic ways of looking at the world that are revealed not only in their life story but also in their professional work. It seeks to provide the first empirical test of this hypothesis using systematic methods for data selection, interpretation, and matching, as applied to the case of B. F. Skinner. Using the salience identifier "primacy" (Alexander, 1990), Skinner's first research design and the first paragraph of his autobiography were selected for analysis. Adopting a personological approach to interpretation, "scripts" (Tomkins, 1987) were derived from these materials by blind and independent coders. A matching task (Allport, 1961) then indicated that the scripts derived from Skinner's work and life were substantially similar and significantly more similar than random pairs of scripts . A search through other autobiographical and professional writings by Skinner revealed that the elements of the discovered script appear recurrently in his imagery.

  4. The Population Ecology of Technology: An Empirical Study of US Biotechnology Patents from 1976 to 2003.

    PubMed

    van den Oord, Ad; van Witteloostuijn, Arjen

    2017-01-01

    A detailed understanding of technological change as an evolutionary process is currently not well understood. To increase our understanding, we build upon theory from organizational ecology to develop a model of endogenous technological growth and determine to what extent the pattern of technological growth can be attributed to the structural or systemic characteristics of the technology itself. Through an empirical investigation of patent data in the biotechnology industry from 1976 to 2003, we find that a technology's internal (i.e., density and diversity) ecological characteristics have a positive effect on its growth rate. The niche's external characteristics of crowding and status have a negative effect on its growth rate. Hence, applying theory from organizational ecology increases our understanding of technological change as an evolutionary process. We discuss the implications of our findings for the study of technological growth and evolution, and suggest avenues for further research.

  5. Ab initio based empirical potential used to study the mechanical properties of molybdenum

    NASA Astrophysics Data System (ADS)

    Park, Hyoungki; Fellinger, Michael R.; Lenosky, Thomas J.; Tipton, William W.; Trinkle, Dallas R.; Rudin, Sven P.; Woodward, Christopher; Wilkins, John W.; Hennig, Richard G.

    2012-06-01

    Density-functional theory energies, forces, and elastic constants determine the parametrization of an empirical, modified embedded-atom method potential for molybdenum. The accuracy and transferability of the potential are verified by comparison to experimental and density-functional data for point defects, phonons, thermal expansion, surface and stacking fault energies, and ideal shear strength. Searching the energy landscape predicted by the potential using a genetic algorithm verifies that it reproduces not only the correct bcc ground state of molybdenum but also all low-energy metastable phases. The potential is also applicable to the study of plastic deformation and used to compute energies, core structures, and Peierls stresses of screw and edge dislocations.

  6. The Population Ecology of Technology: An Empirical Study of US Biotechnology Patents from 1976 to 2003

    PubMed Central

    van den Oord, Ad; van Witteloostuijn, Arjen

    2017-01-01

    A detailed understanding of technological change as an evolutionary process is currently not well understood. To increase our understanding, we build upon theory from organizational ecology to develop a model of endogenous technological growth and determine to what extent the pattern of technological growth can be attributed to the structural or systemic characteristics of the technology itself. Through an empirical investigation of patent data in the biotechnology industry from 1976 to 2003, we find that a technology’s internal (i.e., density and diversity) ecological characteristics have a positive effect on its growth rate. The niche’s external characteristics of crowding and status have a negative effect on its growth rate. Hence, applying theory from organizational ecology increases our understanding of technological change as an evolutionary process. We discuss the implications of our findings for the study of technological growth and evolution, and suggest avenues for further research. PMID:28081570

  7. [Determinants of equity in financing medicines in Argentina: an empirical study].

    PubMed

    Dondo, Mariana; Monsalvo, Mauricio; Garibaldi, Lucas A

    2016-01-01

    Medicines are an important part of household health spending. A progressive system for financing drugs is thus essential for an equitable health system. Some authors have proposed that the determinants of equity in drug financing are socioeconomic, demographic, and associated with public interventions, but little progress has been made in the empirical evaluation and quantification of their relative importance. The current study estimated quantile regressions at the provincial level in Argentina and found that old age (> 65 years), unemployment, the existence of a public pharmaceutical laboratory, treatment transfers, and a health system orientated to primary care were important predictors of progressive payment schemes. Low income, weak institutions, and insufficient infrastructure and services were associated with the most regressive social responses to health needs, thereby aggravating living conditions and limiting development opportunities.

  8. The Association between Peace and Life Expectancy: An Empirical Study of the World Countries

    PubMed Central

    YAZDI FEYZABADI, Vahid; HAGHDOOST, Aliakbar; MEHROLHASSANI, Mohammad Hossein; AMINIAN, Zahra

    2015-01-01

    Background: Although theoretically peace affects health, few published evidence for such an association was empirically available. This study aimed to explore the association between peace and life expectancy (LE) among the world countries. Methods: In an ecological study and using random effects regression model, we examined the association between peace and LE among world countries between 2007 and 2012. The LE at birth and global peace index (GPI: a score between 1 and 5, higher score means lower peace) were selected as outcome and main predictor variables, respectively. We adjusted their association for the gross national income (GNI) per capita and education index (EI). Data were obtained from the Institute for Economics and Peace (IEP) and UNDP (United Nations Development Programme (UNDP). Numbers of included countries were 158 based on the available data. Results: GPI had a negative, considerable, and statistically significant effect on LE (standardized coefficient −0.039; 95% CI: −0.058, −0.019). This association was also significant even after the adjustment for EI (−0.019; 95% CI: −0.035, −0.003), GNI (−0.035; 95% CI: −0.055, −0.015), and both EI and GNI (−0.017; 95% CI: −0.033, −0.001). The full model showed that around 0.61 of the variation of LE among countries may be explained by the GPI, EI and GNI per capita. Conclusion: The contribution of peace as a global determinant of LE was empirically considerable even after the adjustment for the economic and education levels of countries. This implies that governments should make efforts to settle peace through implementing good governance based on interactions with both public and other countries. PMID:25905077

  9. Structural Patterns in Empirical Research Articles: A Cross-Disciplinary Study

    ERIC Educational Resources Information Center

    Lin, Ling; Evans, Stephen

    2012-01-01

    This paper presents an analysis of the major generic structures of empirical research articles (RAs), with a particular focus on disciplinary variation and the relationship between the adjacent sections in the introductory and concluding parts. The findings were derived from a close "manual" analysis of 433 recent empirical RAs from high-impact…

  10. Lessons Learned on Benchmarking from the International Human Reliability Analysis Empirical Study

    SciTech Connect

    Ronald L. Boring; John A. Forester; Andreas Bye; Vinh N. Dang; Erasmia Lois

    2010-06-01

    The International Human Reliability Analysis (HRA) Empirical Study is a comparative benchmark of the prediction of HRA methods to the performance of nuclear power plant crews in a control room simulator. There are a number of unique aspects to the present study that distinguish it from previous HRA benchmarks, most notably the emphasis on a method-to-data comparison instead of a method-to-method comparison. This paper reviews seven lessons learned about HRA benchmarking from conducting the study: (1) the dual purposes of the study afforded by joining another HRA study; (2) the importance of comparing not only quantitative but also qualitative aspects of HRA; (3) consideration of both negative and positive drivers on crew performance; (4) a relatively large sample size of crews; (5) the use of multiple methods and scenarios to provide a well-rounded view of HRA performance; (6) the importance of clearly defined human failure events; and (7) the use of a common comparison language to “translate” the results of different HRA methods. These seven lessons learned highlight how the present study can serve as a useful template for future benchmarking studies.

  11. Clinical Applications of Evaluation Studies.

    ERIC Educational Resources Information Center

    Brown, Barry S.

    A series of followup investigations exploring the impact of methadone maintenance treatment, methadone detoxification treatment, therapeutic communities, and outpatient drug-free treatment for the drug abuser was conducted. Limitations of these modalities were revealed in the followup studies. Implications for treatment and policy include: (1)…

  12. Lessons with Living Harvest Mice: An Empirical Study of Their Effects on Intrinsic Motivation and Knowledge Acquisition

    ERIC Educational Resources Information Center

    Wilde, Matthias; Hubmann, Jona Samuel; Lorenzen, Simone; Meyer, Annika; Randler, Christoph

    2012-01-01

    The aim of this study was to evaluate the effects of living animals on pupils' intrinsic motivation and knowledge. Various studies from the late 1970s and 1980s stress the high effectiveness of authentic learning experiences in pupils' knowledge acquisition. However, there are only few current empirical studies on this topic. The research question…

  13. Clinical decision making about child and adolescent anxiety disorders using the Achenbach system of empirically based assessment.

    PubMed

    Van Meter, Anna; Youngstrom, Eric; Youngstrom, Jennifer Kogos; Ollendick, Thomas; Demeter, Christine; Findling, Robert L

    2014-01-01

    Anxiety disorders are common among children but can be difficult to diagnose. An actuarial approach to the diagnosis of anxiety may improve the efficiency and accuracy of the process. The objectives of this study were to determine the clinical utility of the Achenbach Child Behavior Checklist (CBCL) and Youth Self Report (YSR), two widely used assessment tools, for diagnosing anxiety disorders in youth and to aid clinicians in incorporating scale scores into an actuarial approach to diagnosis through a clinical vignette. Demographically diverse youth, 5 to 18 years of age, were drawn from two samples; one (N = 1,084) was recruited from a research center, and the second (N = 651) was recruited from an urban community mental health center. Consensus diagnoses integrated information from semistructured interview, family history, treatment history, and clinical judgment. The CBCL and YSR internalizing problems T scores discriminated cases with any anxiety disorder or with generalized anxiety disorder from all other diagnoses in both samples (ps < .0005); the two scales had equivalent discriminative validity (ps > .05 for tests of difference). No other scales, nor any combination of scales, significantly improved on the performance of the Internalizing scale. In the highest risk group, Internalizing scores greater than 69 (CBCL) or greater than 63 (YSR) resulted in a Diagnostic Likelihood Ratio of 1.5; low scores reduced the likelihood of anxiety disorders by a factor of 4. Combined with other risk factor information in an actuarial approach to assessment and diagnosis, the CBCL and YSR Internalizing scales provide valuable information about whether a youth is likely suffering from an anxiety disorder.

  14. [Clinical research III. The causality studies].

    PubMed

    Talavera, Juan O; Wacher-Rodarte, Niels H; Rivas-Ruiz, Rodolfo

    2011-01-01

    The need to solve a clinical problem leads us to establish a starting point to address (risk, prognosis or treatment studies), all these cases seek to attribute causality. Clinical reasoning described in the book Clinical Epidemiology. The architecture of clinical research, offers a simple guide to understanding this phenomenon. And proposes three basic components: baseline, maneuver and outcome. In this model, different systematic errors (bias) are described, which may be favored by omitting characteristics of the three basic components. Thus, omissions in the baseline characteristics cause an improper assembly of the population and susceptibility bias, omissions in the application or evaluation of the maneuver provoke performance bias, and omissions in the assessment of out-come cause detection bias and transfer bias. Importantly, if this way of thinking facilitates understanding of the causal phenomenon, the appropriateness of the variables to be selected in the studies to which attribute or not causality, require additional arguments for evaluate clinical relevance.

  15. Gaps in studies of global health education: an empirical literature review.

    PubMed

    Liu, Yan; Zhang, Ying; Liu, Zhaolan; Wang, JianLi

    2015-01-01

    Background Global health has stimulated a lot of students and has attracted the interest of many faculties, thereby initiating the establishment of many academic programs on global health research and education. global health education reflects the increasing attention toward social accountability in medical education. Objective This study aims to identify gaps in the studies on global health education. Design A critical literature review of empirical studies was conducted using Boolean search techniques. Results A total of 238 articles, including 16 reviews, were identified. There had been a boom in the numbers of studies on global health education since 2010. Four gaps were summarized. First, 94.6% of all studies on global health education were conducted in North American and European countries, of which 65.6% were carried out in the United States, followed by Canada (14.3%) and the United Kingdom (9.2%). Only seven studies (2.9%) were conducted in Asian countries, five (2.1%) in Oceania, and two (0.8%) in South American/Caribbean countries. A total of 154 studies (64.4%) were qualitative studies and 64 studies (26.8%) were quantitative studies. Second, elective courses and training or programs were the most frequently used approach for global health education. Third, there was a gap in the standardization of global health education. Finally, it was mainly targeted at medical students, residents, and doctors. It had not granted the demands for global health education of all students majoring in medicine-related studies. Conclusions Global health education would be a potentially influential tool for achieving health equity, reducing health disparities, and also for future professional careers. It is the time to build and expand education in global health, especially among developing countries. Global health education should be integrated into primary medical education. Interdisciplinary approaches and interprofessional collaboration were recommended. Collaboration

  16. Cumulative effect in information diffusion: empirical study on a microblogging network.

    PubMed

    Bao, Peng; Shen, Hua-Wei; Chen, Wei; Cheng, Xue-Qi

    2013-01-01

    Cumulative effect in social contagion underlies many studies on the spread of innovation, behavior, and influence. However, few large-scale empirical studies are conducted to validate the existence of cumulative effect in information diffusion on social networks. In this paper, using the population-scale dataset from the largest Chinese microblogging website, we conduct a comprehensive study on the cumulative effect in information diffusion. We base our study on the diffusion network of message, where nodes are the involved users and links characterize forwarding relationship among them. We find that multiple exposures to the same message indeed increase the possibility of forwarding it. However, additional exposures cannot further improve the chance of forwarding when the number of exposures crosses its peak at two. This finding questions the cumulative effect hypothesis in information diffusion. Furthermore, to clarify the forwarding preference among users, we investigate both structural motif in the diffusion network and temporal pattern in information diffusion process. Findings provide some insights for understanding the variation of message popularity and explain the characteristics of diffusion network.

  17. Analogical scaffolding and the learning of abstract ideas in physics: Empirical studies

    NASA Astrophysics Data System (ADS)

    Podolefsky, Noah S.; Finkelstein, Noah D.

    2007-12-01

    Previously, we proposed a model of student reasoning which combines the roles of representation, analogy, and layering of meaning—analogical scaffolding [Podolefsky and Finkelstein, Phys. Rev. ST Phys. Educ. Res. 3, 010109 (2007)]. The present empirical studies build on this model to examine its utility and demonstrate the vital intertwining of representation, analogy, and conceptual learning in physics. In two studies of student reasoning using analogy, we show that representations couple to students’ existing prior knowledge and also lead to the dynamic formation of new knowledge. Students presented with abstract, concrete, or blended (both abstract and concrete) representations produced markedly different response patterns. In the first study, using analogies to scaffold understanding of electromagnetic (EM) waves, students in the blend group were more likely to reason productively about EM waves than students in the abstract group by as much as a factor of 3 (73% vs 24% correct, p=0.002 ). In the second study, examining representation use within one domain (sound waves), the blend group was more likely to reason productively about sound waves than the abstract group by as much as a factor of 2 (48% vs 23% correct, p=0.002 ). Using the analogical scaffolding model we examine when and why students succeed and fail to use analogies and interpret representations appropriately.

  18. Advances in clinical study of curcumin.

    PubMed

    Yang, Chunfen; Su, Xun; Liu, Anchang; Zhang, Lin; Yu, Aihua; Xi, Yanwei; Zhai, Guangxi

    2013-01-01

    Curcumin has been estimated as a potential agent for many diseases and attracted great attention owing to its various pharmacological activities, including anti-cancer, and anti-inflammatory. Now curcumin is being applied to a number of patients with breast cancer, rheumatoid arthritis, Alzheimer's disease, colorectal cancer, psoriatic, etc. Several clinical trials have stated that curcumin is safe enough and effective. The objective of this article was to summarize the clinical studies of curcumin, and give a reference for future studies.

  19. Near fault broadband ground motion simulation with empirical Green's functions: the Upper Rhine Graben case study

    NASA Astrophysics Data System (ADS)

    Del Gaudio, Sergio; Hok, Sébastian; Causse, Mathieu; Festa, Gaetano; Lancieri, Maria

    2016-04-01

    A fundamental stage in seismic hazard assessment is the prediction of realistic ground motion for potential future earthquakes. To do so, one of the steps is to make an estimation of the expected ground motion level and this is commonly done by the use of ground motion prediction equations (GMPEs). Nevertheless GMPEs do not represent the whole variety of source processes and this can lead to incorrect estimates for some specific case studies, such as in the near-fault range because of the lack of records of large earthquakes at short distances. In such cases, ground motion simulations can be a valid tool to complement prediction equations for scenario studies, provided that both source and propagation are accurately described and uncertainties properly addressed. Such simulations, usually referred to as "blind", require the generation of a population of ground motion records that represent the natural variability of the source process for the target earthquake scenario. In this study we performed simulations using the empirical Green's function technique, which consists in using records of small earthquakes as the medium transfer function provided the availability of small earthquakes located close to the target fault and recorded at the target site. The main advantage of this technique is that it does not require a detailed knowledge of the propagation medium, which is not always possible, but requires availability of high quality records of small earthquakes in the target area. We couple this empirical approach with a k-2 kinematic source model, which naturally let us to introduce high frequency in the source description. Here we present an application of our technique to the Upper Rhine Graben. This is an active seismic region with a moderate rate of seismicity and for which it is interesting to provide ground motion estimation in the vicinity of the faults to be compared with estimations traditionally provided by GMPEs in a seismic hazard evaluation study. We

  20. Use of anecdotal notes by clinical nursing faculty: a descriptive study.

    PubMed

    Hall, Mellisa A; Daly, Barbara J; Madigan, Elizabeth A

    2010-03-01

    Although the use of anecdotal notes by faculty to document clinical performance is thought to be a common practice, no empirical study of this evaluation tool has been conducted. To investigate the frequency and pattern of use, a faculty questionnaire was developed using the Context, Input, Process, Product (CIPP) evaluation model as a framework. The model was adapted to focus on clinical nursing education. Sixty-four nursing faculty from six schools participated in the regional study. A descriptive design was used to collect quantitative data from clinical faculty. Findings indicated that 97% of clinical faculty use anecdotal notes during the student evaluation process, and the majority of faculty do so on a weekly basis. Based on faculty feedback and the CIPP evaluation model, a clinical nursing faculty tool was developed after study completion to support clinical faculty in note use.

  1. Managing the Services Supply Chain in the Department of Defense: An Empirical Study of Current Management Practices

    DTIC Science & Technology

    2009-04-22

    ååì~ä=^Åèìáëáíáçå= oÉëÉ~êÅÜ=póãéçëáìã= MANAGING THE SERVICES SUPPLY CHAIN IN THE DEPARTMENT OF DEFENSE: AN EMPIRICAL STUDY OF CURRENT MANAGEMENT...TITLE AND SUBTITLE Managing the Services Supply Chain in the Department of Defense: An Empirical Study of Current Management Practices 5a. CONTRACT...INTENTIONALLY LEFT BLANK = = ==================aÉÑÉåëÉ=^Åèìáëáíáçå=áå=qê~åëáíáçå======== - 279 - = = Managing the Services Supply Chain in the

  2. Studying Regional Wave Source Time Functions Using the Empirical Green's Function Method: Application to Central Asia

    NASA Astrophysics Data System (ADS)

    Xie, J.; Schaff, D. P.; Chen, Y.; Schult, F.

    2013-12-01

    Reliably estimated source time functions (STFs) from high-frequency regional waveforms, such as Lg, Pn and Pg, provide important input for seismic source studies, explosion detection and discrimination, and minimization of parameter trade-off in attenuation studies. We have searched for candidate pairs of larger and small earthquakes in and around China that share the same focal mechanism but significantly differ in magnitudes, so that the empirical Green's function (EGF) method can be applied to study the STFs of the larger events. We conducted about a million deconvolutions using waveforms from 925 earthquakes, and screened the deconvolved traces to exclude those that are from event pairs that involved different mechanisms. Only 2,700 traces passed this screening and could be further analyzed using the EGF method. We have developed a series of codes for speeding up the final EGF analysis by implementing automations and user-graphic interface procedures. The codes have been fully tested with a subset of screened data and we are currently applying them to all the screened data. We will present a large number of deconvolved STFs retrieved using various phases (Lg, Pn, Sn and Pg and coda) with information on any directivities, any possible dependence of pulse durations on the wave types, on scaling relations for the pulse durations and event sizes, and on the estimated source static stress drops.

  3. Interdigitated silver-polymer-based antibacterial surface system activated by oligodynamic iontophoresis - an empirical characterization study.

    PubMed

    Shirwaiker, Rohan A; Wysk, Richard A; Kariyawasam, Subhashinie; Voigt, Robert C; Carrion, Hector; Nembhard, Harriet Black

    2014-02-01

    There is a pressing need to control the occurrences of nosocomial infections due to their detrimental effects on patient well-being and the rising treatment costs. To prevent the contact transmission of such infections via health-critical surfaces, a prophylactic surface system that consists of an interdigitated array of oppositely charged silver electrodes with polymer separations and utilizes oligodynamic iontophoresis has been recently developed. This paper presents a systematic study that empirically characterizes the effects of the surface system parameters on its antibacterial efficacy, and validates the system's effectiveness. In the first part of the study, a fractional factorial design of experiments (DOE) was conducted to identify the statistically significant system parameters. The data were used to develop a first-order response surface model to predict the system's antibacterial efficacy based on the input parameters. In the second part of the study, the effectiveness of the surface system was validated by evaluating it against four bacterial species responsible for several nosocomial infections - Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, and Enterococcus faecalis - alongside non-antibacterial polymer (acrylic) control surfaces. The system demonstrated statistically significant efficacy against all four bacteria. The results indicate that given a constant total effective surface area, the system designed with micro-scale features (minimum feature width: 20 μm) and activated by 15 μA direct current will provide the most effective antibacterial prophylaxis.

  4. Minimum sample sizes for population genomics: an empirical study from an Amazonian plant species.

    PubMed

    Nazareno, Alison G; Bemmels, Jordan B; Dick, Christopher W; Lohmann, Lúcia G

    2017-01-12

    High-throughput DNA sequencing facilitates the analysis of large portions of the genome in nonmodel organisms, ensuring high accuracy of population genetic parameters. However, empirical studies evaluating the appropriate sample size for these kinds of studies are still scarce. In this study, we use double-digest restriction-associated DNA sequencing (ddRADseq) to recover thousands of single nucleotide polymorphisms (SNPs) for two physically isolated populations of Amphirrhox longifolia (Violaceae), a nonmodel plant species for which no reference genome is available. We used resampling techniques to construct simulated populations with a random subset of individuals and SNPs to determine how many individuals and biallelic markers should be sampled for accurate estimates of intra- and interpopulation genetic diversity. We identified 3646 and 4900 polymorphic SNPs for the two populations of A. longifolia, respectively. Our simulations show that, overall, a sample size greater than eight individuals has little impact on estimates of genetic diversity within A. longifolia populations, when 1000 SNPs or higher are used. Our results also show that even at a very small sample size (i.e. two individuals), accurate estimates of FST can be obtained with a large number of SNPs (≥1500). These results highlight the potential of high-throughput genomic sequencing approaches to address questions related to evolutionary biology in nonmodel organisms. Furthermore, our findings also provide insights into the optimization of sampling strategies in the era of population genomics.

  5. Instructional Skills for On-the-Job Training and Experiential Learning: An Empirical Study of Japanese Firms

    ERIC Educational Resources Information Center

    Matsuo, Makoto

    2014-01-01

    Despite the effectiveness of on-the-job training (OJT), few systematic empirical studies have been conducted on how OJT trainers instruct trainees in firms. The primary goal of this study was to investigate the characteristics of the trainer's instructional skills for OJT using survey data collected from 715 employees covering 22 firms. Results…

  6. Racial Diversity, Student Religiosity, and School Choice: An Empirical Case Study of Multi-Racial Religious Education

    ERIC Educational Resources Information Center

    Reichard, Joshua D.

    2014-01-01

    This article comprises an empirical case study of student religiosity in the context of urban school choice. The purpose of this study was to compare student religiosity in a racially diverse religious private school to determine whether religious faith is a unifying factor across racial categories. Insofar as school choice has been called…

  7. Evaluation of Empirical Data and Modeling Studies to Support Soil Vapor Intrusion Screening Criteria for Petroleum Hydrocarbon Compounds

    EPA Science Inventory

    This study is an evaluation of empirical data and select modeling studies of the behavior of petroleum hydrocarbon (PHC) vapors in subsurface soils and how they can affect subsurface-to-indoor air vapor intrusion (VI), henceforth referred to as petroleum vapor intrusion or “PVI” ...

  8. Learning Disabilities Empirical Research on Ethnic Minority Students: An Analysis of 22 Years of Studies Published in Selected Refereed Journals.

    ERIC Educational Resources Information Center

    Artiles, Alfredo J.; And Others

    1997-01-01

    A study analyzed 2,378 empirical articles on ethnic minority students published in two learning disability and two special education journals over a 22-year period (1972-94). Studies focused on assessment and testing, sensory-perceptual processing, and placement issues. The majority also compared ethnic groups, used quantitative approaches, and…

  9. How Physics Teachers Approach Innovation: An Empirical Study for Reconstructing the Appropriation Path in the Case of Special Relativity

    ERIC Educational Resources Information Center

    De Ambrosis, Anna; Levrini, Olivia

    2010-01-01

    This paper concerns an empirical study carried out with a group of high school physics teachers engaged in the Module on relativity of a Master course on the teaching of modern physics. The study is framed within the general research issue of how to promote innovation in school via teachers' education and how to foster fruitful interactions…

  10. Does Look-up Frequency Help Reading Comprehension of EFL Learners? Two Empirical Studies of Electronic Dictionaries

    ERIC Educational Resources Information Center

    Koyama, Toshiko; Takeuchi, Osamu

    2007-01-01

    Two empirical studies were conducted in which the differences in Japanese EFL learners' look-up behavior between hand-held electronic dictionaries (EDs) and printed dictionaries (PDs) were investigated. We focus here on the relation between learners' look-up frequency and degree of reading comprehension of the text. In the first study, a total of…

  11. Editorial--Avoiding Unethical Helicobacter pylori Clinical Trials: Susceptibility-Based Studies and Probiotics as Adjuvants.

    PubMed

    Graham, David Y

    2015-10-01

    As a general rule, any clinical study where the result is already known or when the investigator(s) compares an assigned treatment against another assigned treatment known to be ineffective in the study population (e.g., in a population with known clarithromycin resistance) is unethical. As susceptibility-based therapy will always be superior to empiric therapy in any population with a prevalence of antimicrobial resistance >0%, any trial that randomizes susceptibility-based therapy with empiric therapy would be unethical. The journal Helicobacter welcomes susceptibility or culture-guided studies, studies of new therapies, and studies of adjuvants and probiotics. However, the journal will not accept for review any study we judge to be lacking clinical equipoise or which assign subjects to a treatment known to be ineffective, such as a susceptibility-based clinical trial with an empiric therapy comparator. To assist authors, we provide examples and suggestions regarding trial design for comparative studies, for susceptibility-based studies, and for studies testing adjuvants or probiotics.

  12. Empirical study of classification process for two-stage turbo air classifier in series

    NASA Astrophysics Data System (ADS)

    Yu, Yuan; Liu, Jiaxiang; Li, Gang

    2013-05-01

    The suitable process parameters for a two-stage turbo air classifier are important for obtaining the ultrafine powder that has a narrow particle-size distribution, however little has been published internationally on the classification process for the two-stage turbo air classifier in series. The influence of the process parameters of a two-stage turbo air classifier in series on classification performance is empirically studied by using aluminum oxide powders as the experimental material. The experimental results show the following: 1) When the rotor cage rotary speed of the first-stage classifier is increased from 2 300 r/min to 2 500 r/min with a constant rotor cage rotary speed of the second-stage classifier, classification precision is increased from 0.64 to 0.67. However, in this case, the final ultrafine powder yield is decreased from 79% to 74%, which means the classification precision and the final ultrafine powder yield can be regulated through adjusting the rotor cage rotary speed of the first-stage classifier. 2) When the rotor cage rotary speed of the second-stage classifier is increased from 2 500 r/min to 3 100 r/min with a constant rotor cage rotary speed of the first-stage classifier, the cut size is decreased from 13.16 μm to 8.76 μm, which means the cut size of the ultrafine powder can be regulated through adjusting the rotor cage rotary speed of the second-stage classifier. 3) When the feeding speed is increased from 35 kg/h to 50 kg/h, the "fish-hook" effect is strengthened, which makes the ultrafine powder yield decrease. 4) To weaken the "fish-hook" effect, the equalization of the two-stage wind speeds or the combination of a high first-stage wind speed with a low second-stage wind speed should be selected. This empirical study provides a criterion of process parameter configurations for a two-stage or multi-stage classifier in series, which offers a theoretical basis for practical production.

  13. Empirical Study of the Multiaxial, Thermomechanical Behavior of NiTiHf Shape Memory Alloys

    NASA Technical Reports Server (NTRS)

    Shukla, Dhwanil; Noebe, Ronald D.; Stebner Aaron P.

    2013-01-01

    An empirical study was conducted to characterize the multiaxial, thermomechanical responses of new high temperature NiTiHf alloys. The experimentation included loading thin walled tube Ni(sub 50.3)Ti(sub 29.7)Hf(sub 20) alloy samples along both proportional and nonproportional axial-torsion paths at different temperatures while measuring surface strains using stereo digital image correlation. A Ni(sub 50.3)Ti(sub 33.7)Hf(sub 16) alloy was also studied in tension and compression to document the effect of slightly depleting the Hf content on the constitutive responses of NiTiHf alloys. Samples of both alloys were made from nearly texture free polycrystalline material processed by hot extrusion. Analysis of the data shows that very small changes in composition significantly alter NiTiHf alloy properties, as the austenite finish (Af) temperature of the 16-at Hf alloy was found to be approximately 60 C less than the 20-at Hf alloy (approximately 120 C vs. 180 C). In addition, the 16-at Hf alloy exhibited smaller compressive transformation strains (2 vs. 2.5 percent). Multi-axial characterization of the 20-at % Hf alloy showed that while the random polycrystal transformation strains in tension (4 percent) and compression (2.5 percent) are modest in comparison with binary NiTi (6 percent, 4 percent), the torsion performance is superior (7 vs. 4 shear strain width to the pseudoelastic plateau).

  14. Situation Analysis of R & D Activities: An Empirical Study in Iranian Pharmaceutical Companies

    PubMed Central

    Rasekh, Hamid Reza; Mehralian, Gholamhossein; Vatankhah-Mohammadabadi, Abbas Ali

    2012-01-01

    As global competition intensifies, research and development (R & D) organizations need to enhance their strategic management in order to become goal-directed communities for innovation and allocate their resources consistent with their overall R & D strategy. The world pharmaceutical market has undergone fast, unprecedented, tremendous and complex changes in the last several years. The pharmaceutical industry is today still one of the most inventive, innovative and lucrative of the so-called “high-tech” industries. This industry serves a dual role in modern society. On one hand, it is a growing industry, and its output makes a direct contribution to gross domestic product (GDP). On the other side, drugs, this industry’s major output, are an input in the production of good health. The purpose of this study is to evaluate R & D activities of pharmaceutical companies, and also to highlight critical factors which have influential effect on results of these activities. To run this study a valid questionnaire based on literature review and experts’ opinion was designed and delivered to 11 pharmaceutical companies. Empirical data show there is not acceptable situations considering of the factors that should be taken in to account by managers including; management commitment, human resource management, information technology and financial management. Furthermore, we concluded some interesting results related to different aspects of R & D management. In conclusion, managers must be aware about their performance in R & D activities, accordingly they will able to take a comprehensive policy in both national and within the company. PMID:24250532

  15. Hardness Analysis and Empirical Studies of the Relations among Robustness, Topology and Flow in Dynamic Networks.

    PubMed

    Zhou, Xing; Peng, Wei; Xu, Zhen; Yang, Bo

    2015-01-01

    Network robustness is the ability of a network to maintain performance after disruption, thus it is an important index for network designers to refer to. Every actual network has its own topology structure, flow magnitude (scale) and flow distribution. How the robustness relates to these factors still remains unresolved. To analyze the relations, we first established a robustness problem model, studied the hardness of a special case of the model, and generated a lot of representative network instances. We conducted experiments on these instances, deleting 5% to 50% edges on each instance and found that the robustness of a network has an approximate linearity to its structural entropy and flow entropy, when the correlation coefficient between the structure and flow is fixed. We also found that robustness is unlikely to have a relation to the flow scale and edge scale in our model. The empirical studies thus can provide a way of quickly estimating the robustness of real-world networks by using the regression coefficients we obtained during the experiments. We conducted computation on a real-world dataset and got favorable results, which exhibited the effectiveness of the estimation.

  16. Leveraging Label-Independent Features for Classification in Sparsely Labeled Networks: An Empirical Study

    NASA Astrophysics Data System (ADS)

    Gallagher, Brian; Eliassi-Rad, Tina

    We address the problem of within-network classification in sparsely labeled networks. Recent work has demonstrated success with statistical relational learning (SRL) and semi-supervised learning (SSL) on such problems. However, both approaches rely on the availability of labeled nodes to infer the values of missing labels. When few labels are available, the performance of these approaches can degrade. In addition, many such approaches are sensitive to the specific set of nodes labeled. So, although average performance may be acceptable, the performance on a specific task may not. We explore a complimentary approach to within-network classification, based on the use of label-independent (LI) features - i.e., features calculated without using the values of class labels. While previous work has made some use of LI features, the effects of these features on classification performance have not been extensively studied. Here, we present an empirical study in order to better understand these effects. Through experiments on several real-world data sets, we show that the use of LI features produces classifiers that are less sensitive to specific label assignments and can lead to performance improvements of over 40% for both SRL- and SSL-based classifiers. We also examine the relative utility of individual LI features; and show that, in many cases, it is a combination of a few diverse network-based structural characteristics that is most informative.

  17. Definitions of love in a sample of British women: an empirical study using Q methodology.

    PubMed

    Watts, Simon; Stenner, Paul

    2014-09-01

    Social psychological research has increasingly acknowledged that any pretensions to a singular theory of love should be replaced with a concern about its affirmation and what people actually say and do in love's name. Lee's (1977) love styles research and Sternberg's (1995) theory of love as a story are prime examples. Despite traditional definitions of love in western cultures being dominated by feminine images and tales of gender difference, however, the personal definitions and experiences of women have received comparatively little empirical attention, particularly in recent years and despite some well-documented changes in their cultural circumstances. This study remedies that situation through presentation of a Q methodological study in which a convenience sample of 59 British women were asked to Q sort 54 single-word descriptors of love to define love as they had experienced it. Factor analysis of the resulting Q sorts revealed six distinct definitions of love, interpreted as 'attraction, passion & romance', 'unconditional love', 'sex & fun', 'friendship & spirituality', 'a permanent commitment', and 'separate people, separate lives'. The six definitions are then discussed in terms of their allegiance to traditionally feminine and/or masculine values and as a means of highlighting the changing face of Britain's relational culture.

  18. Empirical and Analytic Studies Human/Automation Dynamics in Airspace Management for Free Flight

    NASA Technical Reports Server (NTRS)

    Corker, Kevin M.; Planich, G.; Bunzo, M.; Labacqz, J. Victor (Technical Monitor)

    1997-01-01

    NASA and the FAA have initiated programs of research and development to provide flight crew, airline operations and air traffic managers with automation aids to increase capacity in en route and terminal area to support the goals of free flight for safe, flexible, predictable, and efficient operations. To support the development of those aiding systems human performance in automated aiding has been examined in empirical and computationally analytic studies. This paper presents a set of those studies in full mission simulation and the development of a predictive computational model of human performance. We have found that the combination of methodologies provide a powerful design-aiding process. We will describe three research programs in support of Free Flight Operations from the perspective of human performance requirements. We have examined procedures and communications in the use of voice and data-link operation at the transition between unconstrained (enroute) and constrained (terminal) airspace operations. We have examined the timing and form of Center TRACON Automation System (CTAS) advisories in descent. We have investigated the shape and dimensions of an 'alert zone' for air-based separation in unconstrained operations. Finally, we have examined the interaction of a ground-based conflict detection/resolution aiding system, as it interacts with a cockpit-based conflict alerting mechanism. Additional information is contained in the original extended abstract.

  19. A Sediment Budget Case Study: Comparing Watershed Scale Erosion Estimates to Modeled and Empirical Sediment Loads

    NASA Astrophysics Data System (ADS)

    McDavitt, B.; O'Connor, M.

    2003-12-01

    The Pacific Lumber Company Habitat Conservation Plan requires watershed analyses to be conducted on their property. This paper summarizes a portion of that analysis focusing on erosion and sedimentation processes and rates coupled with downstream sediment routing in the Freshwater Creek watershed in northwest California. Watershed scale erosion sources from hillslopes, roads, and channel banks were quantified using field surveys, aerial photo interpretation, and empirical modeling approaches for different elements of the study. Sediment transport rates for bedload were modeled, and sediment transport rates for suspended sediment were estimated based on size distribution of sediment inputs in relation to sizes transported in suspension. Recent short-term, high-quality estimates of suspended sediment yield that a community watershed group collected with technical assistance from the US Forest Service were used to validate the resulting sediment budget. Bedload yield data from an adjacent watershed, Jacoby Creek, provided another check on the sediment budget. The sediment budget techniques and bedload routing models used for this study generated sediment yield estimates that are in good agreement with available data. These results suggest that sediment budget techniques that require moderate levels of fieldwork can be used to provide relatively accurate technical assessments. Ongoing monitoring of sediment sources coupled with sediment routing models and reach scale field data allows for predictions to be made regarding in-channel sediment storage.

  20. Significant factors of aviation insurance and risk management strategy: an empirical study of Taiwanese airline carriers.

    PubMed

    Lin, Yi Hsin; Chang, Yu Hern

    2008-04-01

    Aviation insurance premiums have become a heavy burden for the airline industry since September 11, 2001. Although the industry must constantly balance its operations between profitability and safety, the reality is that airlines are in the business of making money. Therefore, their ability to reduce cost and manage risk is a key factor for success. Unlike past research, which used subjective judgment methods, this study applied quantitative historical data (1999-2000) and gray relation analysis to identify the primary factors influencing ratemaking for aviation insurance premiums. An empirical study of six airlines in Taiwan was conducted to determine these factors and to analyze the management strategies used to deal with them. Results showed that the loss experience and performance of individual airlines were the key elements associated with aviation insurance premiums paid by each airline. By identifying and understanding the primary factors influencing ratemaking for aviation insurance, airlines will better understand their relative operational strengths and weaknesses, and further help top management identify areas for further improvement. Knowledge of these factors combined with effective risk management strategies, may result in lower premiums and operating costs for airline companies.

  1. Relationship between Divergent Thinking and Intelligence: An Empirical Study of the Threshold Hypothesis with Chinese Children

    PubMed Central

    Shi, Baoguo; Wang, Lijing; Yang, Jiahui; Zhang, Mengpin; Xu, Li

    2017-01-01

    The threshold hypothesis is a classical and notable explanation for the relationship between creativity and intelligence. However, few empirical examinations of this theory exist, and the results are inconsistent. To test this hypothesis, this study investigated the relationship between divergent thinking (DT) and intelligence with a sample of 568 Chinese children aged between 11 and 13 years old using testing and questionnaire methods. The study focused on the breakpoint of intelligence and the moderation effect of openness on the relationship between intelligence and DT. The findings were as follows: (1) a breakpoint at the intelligence quotient (IQ) of 109.20 when investigating the relationship between either DT fluency or DT flexibility and intelligence. Another breakpoint was detected at the IQ of 116.80 concerning the correlation between originality and intelligence. The breakpoint of the relation between the composite score of creativity and intelligence occurred at the IQ of 110.10. (2) Openness to experience had a moderating effect on the correlation between the indicators of creativity and intelligence under the breakpoint. Above this point, however, the effect was not significant. The results suggested a relationship between DT and intelligence among Chinese children, which conforms to the threshold hypothesis. Besides, it remains necessary to explore the personality factors accounting for individual differences in the relationship between DT and intelligence. PMID:28275361

  2. Empirical evidence about inconsistency among studies in a pair-wise meta-analysis.

    PubMed

    Rhodes, Kirsty M; Turner, Rebecca M; Higgins, Julian P T

    2016-12-01

    This paper investigates how inconsistency (as measured by the I(2) statistic) among studies in a meta-analysis may differ, according to the type of outcome data and effect measure. We used hierarchical models to analyse data from 3873 binary, 5132 continuous and 880 mixed outcome meta-analyses within the Cochrane Database of Systematic Reviews. Predictive distributions for inconsistency expected in future meta-analyses were obtained, which can inform priors for between-study variance. Inconsistency estimates were highest on average for binary outcome meta-analyses of risk differences and continuous outcome meta-analyses. For a planned binary outcome meta-analysis in a general research setting, the predictive distribution for inconsistency among log odds ratios had median 22% and 95% CI: 12% to 39%. For a continuous outcome meta-analysis, the predictive distribution for inconsistency among standardized mean differences had median 40% and 95% CI: 15% to 73%. Levels of inconsistency were similar for binary data measured by log odds ratios and log relative risks. Fitted distributions for inconsistency expected in continuous outcome meta-analyses using mean differences were almost identical to those using standardized mean differences. The empirical evidence on inconsistency gives guidance on which outcome measures are most likely to be consistent in particular circumstances and facilitates Bayesian meta-analysis with an informative prior for heterogeneity. © 2015 The Authors. Research Synthesis Methods published by John Wiley & Sons, Ltd. © 2015 The Authors. Research Synthesis Methods published by John Wiley & Sons, Ltd.

  3. Empirical evidence about inconsistency among studies in a pair‐wise meta‐analysis

    PubMed Central

    Turner, Rebecca M.; Higgins, Julian P. T.

    2015-01-01

    This paper investigates how inconsistency (as measured by the I2 statistic) among studies in a meta‐analysis may differ, according to the type of outcome data and effect measure. We used hierarchical models to analyse data from 3873 binary, 5132 continuous and 880 mixed outcome meta‐analyses within the Cochrane Database of Systematic Reviews. Predictive distributions for inconsistency expected in future meta‐analyses were obtained, which can inform priors for between‐study variance. Inconsistency estimates were highest on average for binary outcome meta‐analyses of risk differences and continuous outcome meta‐analyses. For a planned binary outcome meta‐analysis in a general research setting, the predictive distribution for inconsistency among log odds ratios had median 22% and 95% CI: 12% to 39%. For a continuous outcome meta‐analysis, the predictive distribution for inconsistency among standardized mean differences had median 40% and 95% CI: 15% to 73%. Levels of inconsistency were similar for binary data measured by log odds ratios and log relative risks. Fitted distributions for inconsistency expected in continuous outcome meta‐analyses using mean differences were almost identical to those using standardized mean differences. The empirical evidence on inconsistency gives guidance on which outcome measures are most likely to be consistent in particular circumstances and facilitates Bayesian meta‐analysis with an informative prior for heterogeneity. © 2015 The Authors. Research Synthesis Methods published by John Wiley & Sons, Ltd. © 2015 The Authors. Research Synthesis Methods published by John Wiley & Sons, Ltd. PMID:26679486

  4. Interpreting observational studies: why empirical calibration is needed to correct p-values

    PubMed Central

    Schuemie, Martijn J; Ryan, Patrick B; DuMouchel, William; Suchard, Marc A; Madigan, David

    2014-01-01

    Often the literature makes assertions of medical product effects on the basis of ‘ p < 0.05’. The underlying premise is that at this threshold, there is only a 5% probability that the observed effect would be seen by chance when in reality there is no effect. In observational studies, much more than in randomized trials, bias and confounding may undermine this premise. To test this premise, we selected three exemplar drug safety studies from literature, representing a case–control, a cohort, and a self-controlled case series design. We attempted to replicate these studies as best we could for the drugs studied in the original articles. Next, we applied the same three designs to sets of negative controls: drugs that are not believed to cause the outcome of interest. We observed how often p < 0.05 when the null hypothesis is true, and we fitted distributions to the effect estimates. Using these distributions, we compute calibrated p-values that reflect the probability of observing the effect estimate under the null hypothesis, taking both random and systematic error into account. An automated analysis of scientific literature was performed to evaluate the potential impact of such a calibration. Our experiment provides evidence that the majority of observational studies would declare statistical significance when no effect is present. Empirical calibration was found to reduce spurious results to the desired 5% level. Applying these adjustments to literature suggests that at least 54% of findings with p < 0.05 are not actually statistically significant and should be reevaluated. © 2013 The Authors. Statistics in Medicine published by John Wiley & Sons Ltd. PMID:23900808

  5. Time-varying volatility in Malaysian stock exchange: An empirical study using multiple-volatility-shift fractionally integrated model

    NASA Astrophysics Data System (ADS)

    Cheong, Chin Wen

    2008-02-01

    This article investigated the influences of structural breaks on the fractionally integrated time-varying volatility model in the Malaysian stock markets which included the Kuala Lumpur composite index and four major sectoral indices. A fractionally integrated time-varying volatility model combined with sudden changes is developed to study the possibility of structural change in the empirical data sets. Our empirical results showed substantial reduction in fractional differencing parameters after the inclusion of structural change during the Asian financial and currency crises. Moreover, the fractionally integrated model with sudden change in volatility performed better in the estimation and specification evaluations.

  6. The Clinical Outcome Study for dysferlinopathy

    PubMed Central

    Harris, Elizabeth; Bladen, Catherine L.; Mayhew, Anna; James, Meredith; Bettinson, Karen; Moore, Ursula; Smith, Fiona E.; Rufibach, Laura; Cnaan, Avital; Bharucha-Goebel, Diana X.; Blamire, Andrew M.; Bravver, Elena; Carlier, Pierre G.; Day, John W.; Díaz-Manera, Jordi; Eagle, Michelle; Grieben, Ulrike; Harms, Matthew; Jones, Kristi J.; Lochmüller, Hanns; Mendell, Jerry R.; Mori-Yoshimura, Madoka; Paradas, Carmen; Pegoraro, Elena; Pestronk, Alan; Salort-Campana, Emmanuelle; Schreiber-Katz, Olivia; Semplicini, Claudio; Spuler, Simone; Stojkovic, Tanya; Straub, Volker; Takeda, Shin'ich; Rocha, Carolina Tesi; Walter, M.C.

    2016-01-01

    Objective: To describe the baseline clinical and functional characteristics of an international cohort of 193 patients with dysferlinopathy. Methods: The Clinical Outcome Study for dysferlinopathy (COS) is an international multicenter study of this disease, evaluating patients with genetically confirmed dysferlinopathy over 3 years. We present a cross-sectional analysis of 193 patients derived from their baseline clinical and functional assessments. Results: There is a high degree of variability in disease onset, pattern of weakness, and rate of progression. No factor, such as mutation class, protein expression, or age at onset, accounted for this variability. Among patients with clinical diagnoses of Miyoshi myopathy or limb-girdle muscular dystrophy, clinical presentation and examination was not strikingly different. Respiratory impairment and cardiac dysfunction were observed in a minority of patients. A substantial delay in diagnosis was previously common but has been steadily reducing, suggesting increasing awareness of dysferlinopathies. Conclusions: These findings highlight crucial issues to be addressed for both optimizing clinical care and planning therapeutic trials in dysferlinopathy. This ongoing longitudinal study will provide an opportunity to further understand patterns and variability in disease progression and form the basis for trial design. PMID:27602406

  7. PDE-based nonlinear diffusion techniques for denoising scientific and industrial images: an empirical study

    NASA Astrophysics Data System (ADS)

    Weeratunga, Sisira K.; Kamath, Chandrika

    2002-05-01

    Removing noise from data is often the first step in data analysis. Denoising techniques should not only reduce the noise, but do so without blurring or changing the location of the edges. Many approaches have been proposed to accomplish this; in this paper, we focus on one such approach, namely the use of non-linear diffusion operators. This approach has been studied extensively from a theoretical viewpoint ever since the 1987 work of Perona and Malik showed that non-linear filters outperformed the more traditional linear Canny edge detector. We complement this theoretical work by investigating the performance of several isotropic diffusion operators on test images from scientific domains. We explore the effects of various parameters such as the choice of diffusivity function, explicit and implicit methods for the discretization of the PDE, and approaches for the spatial discretization of the non-linear operator etc. We also compare these schemes with simple spatial filters and the more complex wavelet-based shrinkage techniques. Our empirical results show that, with an appropriate choice of parameters, diffusion-based schemes can be as effective as competitive techniques.

  8. An empirical study on information spillover effects between the Chinese copper futures market and spot market

    NASA Astrophysics Data System (ADS)

    Liu, Xiangli; Cheng, Siwei; Wang, Shouyang; Hong, Yongmiao; Li, Yi

    2008-02-01

    This study employs a parametric approach based on TGARCH and GARCH models to estimate the VaR of the copper futures market and spot market in China. Considering the short selling mechanism in the futures market, the paper introduces two new notions: upside VaR and extreme upside risk spillover. And downside VaR and upside VaR are examined by using the above approach. Also, we use Kupiec’s [P.H. Kupiec, Techniques for verifying the accuracy of risk measurement models, Journal of Derivatives 3 (1995) 73-84] backtest to test the power of our approaches. In addition, we investigate information spillover effects between the futures market and the spot market by employing a linear Granger causality test, and Granger causality tests in mean, volatility and risk respectively. Moreover, we also investigate the relationship between the futures market and the spot market by using a test based on a kernel function. Empirical results indicate that there exist significant two-way spillovers between the futures market and the spot market, and the spillovers from the futures market to the spot market are much more striking.

  9. Empirical study of the relationships between financial leverage and capital costs for electric utilities

    SciTech Connect

    Gapenski, L.C.

    1987-01-01

    A major element in utility regulation is the setting of just and reasonable allowed rates of return. This rate is a weighted average of the costs of the types of capital employed by the firm, and the weights should reflect the firm's target capital structure. The information required to set the target, or optimal, capital structure includes the relationships between the component costs of capital and the amount of financial leverage used. The primary objective of this study is to empirically estimate the relationships between financial leverage and the costs of common equity and debt for electric utilities. Two different approaches were used to estimate the relationships. First, an econometric model was developed with the component cost as the dependent variable and leverage as the independent variable. Other factors were included as independent variables to account for nonconstant business risk. Second, a model was developed using the bond-rating guidelines and bond yields reported by Standard and Poor's Corporation. The data set consisted of about 73 electric utilities for 1983 and 1984. The results indicated a strong positive relationship between financial leverage and the costs of debt and equity.

  10. Time Domain Strain/Stress Reconstruction Based on Empirical Mode Decomposition: Numerical Study and Experimental Validation

    PubMed Central

    He, Jingjing; Zhou, Yibin; Guan, Xuefei; Zhang, Wei; Zhang, Weifang; Liu, Yongming

    2016-01-01

    Structural health monitoring has been studied by a number of researchers as well as various industries to keep up with the increasing demand for preventive maintenance routines. This work presents a novel method for reconstruct prompt, informed strain/stress responses at the hot spots of the structures based on strain measurements at remote locations. The structural responses measured from usage monitoring system at available locations are decomposed into modal responses using empirical mode decomposition. Transformation equations based on finite element modeling are derived to extrapolate the modal responses from the measured locations to critical locations where direct sensor measurements are not available. Then, two numerical examples (a two-span beam and a 19956-degree of freedom simplified airfoil) are used to demonstrate the overall reconstruction method. Finally, the present work investigates the effectiveness and accuracy of the method through a set of experiments conducted on an aluminium alloy cantilever beam commonly used in air vehicle and spacecraft. The experiments collect the vibration strain signals of the beam via optical fiber sensors. Reconstruction results are compared with theoretical solutions and a detailed error analysis is also provided. PMID:27537889

  11. Reviewing the effort-reward imbalance model: drawing up the balance of 45 empirical studies.

    PubMed

    van Vegchel, Natasja; de Jonge, Jan; Bosma, Hans; Schaufeli, Wilmar

    2005-03-01

    The present paper provides a review of 45 studies on the Effort-Reward Imbalance (ERI) Model published from 1986 to 2003 (inclusive). In 1986, the ERI Model was introduced by Siegrist et al. (Biological and Psychological Factors in Cardiovascular Disease, Springer, Berlin, 1986, pp. 104-126; Social Science & Medicine 22 (1986) 247). The central tenet of the ERI Model is that an imbalance between (high) efforts and (low) rewards leads to (sustained) strain reactions. Besides efforts and rewards, overcommitment (i.e., a personality characteristic) is a crucial aspect of the model. Essentially, the ERI Model contains three main assumptions, which could be labeled as (1) the extrinsic ERI hypothesis: high efforts in combination with low rewards increase the risk of poor health, (2) the intrinsic overcommitment hypothesis: a high level of overcommitment may increase the risk of poor health, and (3) the interaction hypothesis: employees reporting an extrinsic ERI and a high level of overcommitment have an even higher risk of poor health. The review showed that the extrinsic ERI hypothesis has gained considerable empirical support. Results for overcommitment remain inconsistent and the moderating effect of overcommitment on the relation between ERI and employee health has been scarcely examined. Based on these review results suggestions for future research are proposed.

  12. Empirical Study of User Preferences Based on Rating Data of Movies.

    PubMed

    Zhao, YingSi; Shen, Bo

    2016-01-01

    User preference plays a prominent role in many fields, including electronic commerce, social opinion, and Internet search engines. Particularly in recommender systems, it directly influences the accuracy of the recommendation. Though many methods have been presented, most of these have only focused on how to improve the recommendation results. In this paper, we introduce an empirical study of user preferences based on a set of rating data about movies. We develop a simple statistical method to investigate the characteristics of user preferences. We find that the movies have potential characteristics of closure, which results in the formation of numerous cliques with a power-law size distribution. We also find that a user related to a small clique always has similar opinions on the movies in this clique. Then, we suggest a user preference model, which can eliminate the predictions that are considered to be impracticable. Numerical results show that the model can reflect user preference with remarkable accuracy when data elimination is allowed, and random factors in the rating data make prediction error inevitable. In further research, we will investigate many other rating data sets to examine the universality of our findings.

  13. Empirical Study of User Preferences Based on Rating Data of Movies

    PubMed Central

    Zhao, YingSi; Shen, Bo

    2016-01-01

    User preference plays a prominent role in many fields, including electronic commerce, social opinion, and Internet search engines. Particularly in recommender systems, it directly influences the accuracy of the recommendation. Though many methods have been presented, most of these have only focused on how to improve the recommendation results. In this paper, we introduce an empirical study of user preferences based on a set of rating data about movies. We develop a simple statistical method to investigate the characteristics of user preferences. We find that the movies have potential characteristics of closure, which results in the formation of numerous cliques with a power-law size distribution. We also find that a user related to a small clique always has similar opinions on the movies in this clique. Then, we suggest a user preference model, which can eliminate the predictions that are considered to be impracticable. Numerical results show that the model can reflect user preference with remarkable accuracy when data elimination is allowed, and random factors in the rating data make prediction error inevitable. In further research, we will investigate many other rating data sets to examine the universality of our findings. PMID:26735847

  14. An empirical study on the driving mechanism of proactive corporate environmental management in China.

    PubMed

    Liu, Xianbing; Liu, Beibei; Shishime, Tomohiro; Yu, Qinqin; Bi, Jun; Fujitsuka, Tetsuro

    2010-08-01

    Environmentalism in China is under transformation from the traditional command and control model to emphasize the advantages of economic tools and encourage the participation of the public. Firms are much more aware of the importance of environmental issues, and some of them have practiced environmental activities beyond compliance. In order to help understand the driving mechanism of proactive corporate environmental behaviors from the firm's perspective, this paper identifies the drivers affecting the proactive environmental management level (EML(p)) based on the institutional theory, and gives an empirical study on the firms based in Changshu city of Jiangsu Province, China. The usable data, collected from the 117 valid respondents in a questionnaire survey, indicates that EML(p) is still moderately low currently. Less than 10% of the samples are practicing all the six categorized types of voluntary environmental activities. The econometric exercise confirms a significantly positive effect of the externally mimetic pressure on EML(p), which may attribute to a higher sensitivity of Chinese companies to the market factors. However, the roles of the general public and industrial associations are not significant, showing the marginal power of selected normative pressures. Regarding internal factors, firms, which view environmental issues as opportunities and often arrange internal environmental training, are more likely to adopt proactive environmental activities. More concerns from the general public like neighborhood communities and mass media shall be addressed to enhance the normative power to improve EML(p) in China from the future perspective.

  15. Digital ethnography and the social dimension of introspection: an empirical study in two Colombian schools.

    PubMed

    Rieken, Johannes; Garcia-Sanchez, Efraín; Trujillo, Mónica Pérez; Bear, Daniel

    2015-06-01

    We developed a teaching-led research project to empirically ground methodological reflection about digital ethnography. Drawing on Cordelois' collective ethnographic observation approach, fifteen emerging professionals (from a private general education university and a Police Academy in Bogota) collaborated in a method seminar on digital ethnography. They worked in cross-institutional research teams, each carrying SenseCams for 3 days. Students had a dual role as both participants and observers during self-confrontation interviews. The research design enabled emerging professionals to introspect about what it is to be a member of their institution. The SenseCam provided an additional opportunity for observation as it elicited different reactions in the two institutions. The fact that SenseCams produce sequential accounts of activity as well as its situated nature made apparent the autonomy to study and solve daily issues (e.g. transport, security, commitments) by students from the university, while students in the police academy are more focused on responding to unforeseen activities (e.g. police services, unexpected requests). Finally, our research highlights the relevance of the social dimension of introspection for digital ethnography. How digital data that captures an individual perspective is negotiated in a group becomes a key methodological question.

  16. Empirical study of the group delay dispersion achievable with multilayer mirrors.

    PubMed

    Pervak, V; Fedorov, V; Pervak, Yu A; Trubetskov, M

    2013-07-29

    With the help of the most advanced algorithms we obtained many dozens of multilayer dispersive mirror designs to empirically find limits for the maximum achievable negative value of the group delay dispersion (GDD). This value depends on the total thickness of coatings and layer material combination. Nb(2)O(5)/SiO(2) and Ta(2)O(50/SiO(2) combinations are studied in detail, for combinations HfO(2)/SiO(2) and TiO(2)/SiO(2) we obtained estimations for two bandwidths. We also show that reasonable values of third-order dispersion have no significant impact on the obtained results. Current state-of-the-art technology allows to produce designs with total physical thicknesses slightly higher than 10 µm and to achieve maximum negative GDD values corresponding to this total design thickness. Designs with total physical thickness of 15 µm and 20 µm are not realized yet due to high sensitivity to deposition errors.

  17. An empirical study of tissue banking in Australia: navigating regulatory and ethical challenges.

    PubMed

    Clark, Georgina; Lipworth, Wendy; Les, Bokey; Little, J M; Kerridge, Ian H

    2006-08-01

    Collections of tumour samples can be an invaluable resource for medical research. There are, however, numerous ethical and legal challenges associated with tumour banking. While there has been extensive discussion of these issues in the legal and ethical literature, there are few available empirical data in relation to the activities of tumour banks in Australia, their practices around ethically charged issues, and their success in implementing complex regulatory guidelines. The aim of this study was to gain more information about the activities of tumour banks in New South Wales, Australia, with a particular focus on their management of, and attitudes towards, ethical and regulatory issues. A survey of 27 tumour collection and research facilities was conducted using a 55-item questionnaire. There is significant heterogeneity of research methodologies as well as of methods for gaining consent and ensuring donor privacy, and there is general concern among the research community about ethical and regulatory issues related to tumour banking. Heterogeneity of practice and uncertainty about ethical and regulatory requirements is problematic in its potential to hinder research and its potential to generate the space for unethical practice, whether intentional or unintentional. There is a pressing need to address these issues so that tumour banks can be used in the most ethical and efficient way possible.

  18. Haptic stylus and empirical studies on braille, button, and texture display.

    PubMed

    Kyung, Ki-Uk; Lee, Jun-Young; Park, Junseok

    2008-01-01

    This paper presents a haptic stylus interface with a built-in compact tactile display module and an impact module as well as empirical studies on Braille, button, and texture display. We describe preliminary evaluations verifying the tactile display's performance indicating that it can satisfactorily represent Braille numbers for both the normal and the blind. In order to prove haptic feedback capability of the stylus, an experiment providing impact feedback mimicking the click of a button has been conducted. Since the developed device is small enough to be attached to a force feedback device, its applicability to combined force and tactile feedback display in a pen-held haptic device is also investigated. The handle of pen-held haptic interface was replaced by the pen-like interface to add tactile feedback capability to the device. Since the system provides combination of force, tactile and impact feedback, three haptic representation methods for texture display have been compared on surface with 3 texture groups which differ in direction, groove width, and shape. In addition, we evaluate its capacity to support touch screen operations by providing tactile sensations when a user rubs against an image displayed on a monitor.

  19. Empirical Study on Designing of Gaze Tracking Camera Based on the Information of User's Head Movement.

    PubMed

    Pan, Weiyuan; Jung, Dongwook; Yoon, Hyo Sik; Lee, Dong Eun; Naqvi, Rizwan Ali; Lee, Kwan Woo; Park, Kang Ryoung

    2016-08-31

    Gaze tracking is the technology that identifies a region in space that a user is looking at. Most previous non-wearable gaze tracking systems use a near-infrared (NIR) light camera with an NIR illuminator. Based on the kind of camera lens used, the viewing angle and depth-of-field (DOF) of a gaze tracking camera can be different, which affects the performance of the gaze tracking system. Nevertheless, to our best knowledge, most previous researches implemented gaze tracking cameras without ground truth information for determining the optimal viewing angle and DOF of the camera lens. Eye-tracker manufacturers might also use ground truth information, but they do not provide this in public. Therefore, researchers and developers of gaze tracking systems cannot refer to such information for implementing gaze tracking system. We address this problem providing an empirical study in which we design an optimal gaze tracking camera based on experimental measurements of the amount and velocity of user's head movements. Based on our results and analyses, researchers and developers might be able to more easily implement an optimal gaze tracking system. Experimental results show that our gaze tracking system shows high performance in terms of accuracy, user convenience and interest.

  20. Gaps in studies of global health education: an empirical literature review

    PubMed Central

    Liu, Yan; Zhang, Ying; Liu, Zhaolan; Wang, JianLi

    2015-01-01

    Background Global health has stimulated a lot of students and has attracted the interest of many faculties, thereby initiating the establishment of many academic programs on global health research and education. global health education reflects the increasing attention toward social accountability in medical education. Objective This study aims to identify gaps in the studies on global health education. Design A critical literature review of empirical studies was conducted using Boolean search techniques. Results A total of 238 articles, including 16 reviews, were identified. There had been a boom in the numbers of studies on global health education since 2010. Four gaps were summarized. First, 94.6% of all studies on global health education were conducted in North American and European countries, of which 65.6% were carried out in the United States, followed by Canada (14.3%) and the United Kingdom (9.2%). Only seven studies (2.9%) were conducted in Asian countries, five (2.1%) in Oceania, and two (0.8%) in South American/Caribbean countries. A total of 154 studies (64.4%) were qualitative studies and 64 studies (26.8%) were quantitative studies. Second, elective courses and training or programs were the most frequently used approach for global health education. Third, there was a gap in the standardization of global health education. Finally, it was mainly targeted at medical students, residents, and doctors. It had not granted the demands for global health education of all students majoring in medicine-related studies. Conclusions Global health education would be a potentially influential tool for achieving health equity, reducing health disparities, and also for future professional careers. It is the time to build and expand education in global health, especially among developing countries. Global health education should be integrated into primary medical education. Interdisciplinary approaches and interprofessional collaboration were recommended. Collaboration

  1. Empirical Testing of a Theoretical Extension of the Technology Acceptance Model: An Exploratory Study of Educational Wikis

    ERIC Educational Resources Information Center

    Liu, Xun

    2010-01-01

    This study extended the technology acceptance model and empirically tested the new model with wikis, a new type of educational technology. Based on social cognitive theory and the theory of planned behavior, three new variables, wiki self-efficacy, online posting anxiety, and perceived behavioral control, were added to the original technology…

  2. Impact of Intellectual Capital on Organisational Performance: An Empirical Study of Companies in the Hang Seng Index (Part 2)

    ERIC Educational Resources Information Center

    Chan, Kin Hang

    2009-01-01

    Purpose: The purpose of this paper, which is written in two parts, is to investigate empirically if intellectual capital (IC) has an impact on the financial aspects of organisational performance as well as attempting to identify the IC components that may be the drivers for the leading financial indicators of listed companies. The study sought…

  3. Impact of Intellectual Capital on Organisational Performance: An Empirical Study of Companies in the Hang Seng Index (Part 1)

    ERIC Educational Resources Information Center

    Chan, Kin Hang

    2009-01-01

    Purpose: The purpose of this paper, which is written in two parts, is to investigate empirically if intellectual capital (IC) has an impact on the financial aspects of organisational performance as well as attempting to identify the IC components that may be the drivers for the leading financial indicators of listed companies. The study sought…

  4. Impact of Globalization on Higher Education: An Empirical Study of Education Policy & Planning of Design Education in Hong Kong

    ERIC Educational Resources Information Center

    Lam, Yan Yan

    2010-01-01

    This paper focuses on the impact of globalization in the domain of higher education, particularly, design education. It reviews how globalization may affect educational policy and planning in Hong Kong by drawing on an empirical study involving senior management, a course leader and a design trainer/facilitator. This paper not only illustrates the…

  5. An Empirical Study on Washback Effects of the Internet-Based College English Test Band 4 in China

    ERIC Educational Resources Information Center

    Wang, Chao; Yan, Jiaolan; Liu, Bao

    2014-01-01

    Based on Bailey's washback model, in respect of participants, process and products, the present empirical study was conducted to find the actual washback effects of the internet-based College English Test Band 4 (IB CET-4). The methods adopted are questionnaires, class observation, interview and the analysis of both the CET-4 teaching and testing…

  6. Behavioral Criteria of Mentoring Effectiveness: An Empirical Study of Formal Mentoring Relationships within a Major UK Public Sector Organization

    ERIC Educational Resources Information Center

    Hamlin, Robert G.; Sage, Lesley

    2008-01-01

    This paper describes an empirical study of mentor and mentee behaviors deemed critical for developing healthy mentoring relationships and effective mentoring during the "start up" and "on going" stages of a formal mentoring scheme within a major UK public sector organization. Several identified behavioral categories (criteria)…

  7. Empirical Study of the Role of Government Support and Success Factors in Industry-University-Institute Cooperation

    ERIC Educational Resources Information Center

    Zhimin, Guan; Zhongpeng, Cao; Jin, Tao

    2016-01-01

    Empirical research methods were used to study the state of industry-university-institute collaboration in China and the factors influencing the results of cooperation between members of technological innovation alliances, from the dual perspectives of enterprises and universities/research institutes On the basis of questionnaire surveys of 100…

  8. Influence of Using Challenging Tasks in Biology Classrooms on Students' Cognitive Knowledge Structure: An Empirical Video Study

    ERIC Educational Resources Information Center

    Nawani, Jigna; Rixius, Julia; Neuhaus, Birgit J.

    2016-01-01

    Empirical analysis of secondary biology classrooms revealed that, on average, 68% of teaching time in Germany revolved around processing tasks. Quality of instruction can thus be assessed by analyzing the quality of tasks used in classroom discourse. This quasi-experimental study analyzed how teachers used tasks in 38 videotaped biology lessons…

  9. An Empirical Study on the Application of Cooperative Learning to Comprehensive English Classes in a Chinese Independent College

    ERIC Educational Resources Information Center

    Meng, Ji

    2017-01-01

    This research investigated a comparison between the effect of cooperative learning and lecture teaching on Comprehensive English classes in a Chinese Independent College. An empirical study for two semesters was carried out in the forms of pretest, posttest, questionnaire and interviews. While control class was taught in the conventional way,…

  10. The Impact of Student Composition on Schools' Value-Added Performance: A Comparison of Seven Empirical Studies

    ERIC Educational Resources Information Center

    Timmermans, Anneke C.; Thomas, Sally M.

    2015-01-01

    In many countries, policy makers struggle with the development of value-added indicators of school performance for educational accountability purposes and in particular with the choice whether school context measured in the form of student composition variables should be included. This study investigates differences between 7 empirical studies…

  11. How Do Consumers Evaluate Explainer Videos? An Empirical Study on the Effectiveness and Efficiency of Different Explainer Video Formats

    ERIC Educational Resources Information Center

    Krämer, Andreas; Böhrs, Sandra

    2017-01-01

    There is a significant rise in the use of videos. More and more people use videos not only as a source of information but also as learning tool. This article explores the future potential of explainer videos, a format that conveys complex facts to a target group within a very short time. The findings are based on an empirical study representative…

  12. Two Studies of the Empirical Basis of Two Learning Resource-Oriented Motivational Strategies for Gifted Educators

    ERIC Educational Resources Information Center

    Vladut, Anamaria; Vialle, Wilma; Ziegler, Albert

    2016-01-01

    Two learning resource-oriented motivational strategies for gifted educators are introduced: a homeostatic orientation that aims for balance and an allostatic orientation that aims at growth. In order to establish the empirical basis of these motivational strategies, two studies were conducted with samples of students from a specialized…

  13. PPB | What is a Clinical Study

    Cancer.gov

    The Pleuropulmonary blastoma (PPB) DICER1 Syndrome Study ‹an observational clinical research study‹is enrolling children with PPB and their families. In an observational study, investigators assess health outcomes in groups of participants according to a protocol or research plan.

  14. Risk and Protective Factors of Internet Addiction: A Meta-Analysis of Empirical Studies in Korea

    PubMed Central

    Koo, Hoon Jung

    2014-01-01

    Purpose A meta-analysis of empirical studies performed in Korea was conducted to systematically investigate the associations between the indices of Internet addiction (IA) and psychosocial variables. Materials and Methods Systematic literature searches were carried out using the Korean Studies Information Service System, Research Information Sharing Service, Science Direct, Google Scholar, and references in review articles. The key words were Internet addiction, (Internet) game addiction, and pathological, problematic, and excessive Internet use. Only original research papers using Korean samples published from 1999 to 2012 and officially reviewed by peers were included for analysis. Ninety-five studies meeting the inclusion criteria were identified. Results The magnitude of the overall effect size of the intrapersonal variables associated with internet addiction was significantly higher than that of interpersonal variables. Specifically, IA demonstrated a medium to strong association with "escape from self" and "self-identity" as self-related variables. "Attention problem", "self-control", and "emotional regulation" as control and regulation-relation variables; "addiction and absorption traits" as temperament variables; "anger" and "aggression" as emotion and mood and variables; "negative stress coping" as coping variables were also associated with comparably larger effect sizes. Contrary to our expectation, the magnitude of the correlations between relational ability and quality, parental relationships and family functionality, and IA were found to be small. The strength of the association between IA and the risk and protective factors was found to be higher in younger age groups. Conclusion The findings highlight a need for closer examination of psychosocial factors, especially intrapersonal variables when assessing high-risk individuals and designing intervention strategies for both general IA and Internet game addiction. PMID:25323910

  15. Macro-evolutionary studies of cultural diversity: a review of empirical studies of cultural transmission and cultural adaptation.

    PubMed

    Mace, Ruth; Jordan, Fiona M

    2011-02-12

    A growing body of theoretical and empirical research has examined cultural transmission and adaptive cultural behaviour at the individual, within-group level. However, relatively few studies have tried to examine proximate transmission or test ultimate adaptive hypotheses about behavioural or cultural diversity at a between-societies macro-level. In both the history of anthropology and in present-day work, a common approach to examining adaptive behaviour at the macro-level has been through correlating various cultural traits with features of ecology. We discuss some difficulties with simple ecological associations, and then review cultural phylogenetic studies that have attempted to go beyond correlations to understand the underlying cultural evolutionary processes. We conclude with an example of a phylogenetically controlled approach to understanding proximate transmission pathways in Austronesian cultural diversity.

  16. Macro-evolutionary studies of cultural diversity: a review of empirical studies of cultural transmission and cultural adaptation

    PubMed Central

    Mace, Ruth; Jordan, Fiona M.

    2011-01-01

    A growing body of theoretical and empirical research has examined cultural transmission and adaptive cultural behaviour at the individual, within-group level. However, relatively few studies have tried to examine proximate transmission or test ultimate adaptive hypotheses about behavioural or cultural diversity at a between-societies macro-level. In both the history of anthropology and in present-day work, a common approach to examining adaptive behaviour at the macro-level has been through correlating various cultural traits with features of ecology. We discuss some difficulties with simple ecological associations, and then review cultural phylogenetic studies that have attempted to go beyond correlations to understand the underlying cultural evolutionary processes. We conclude with an example of a phylogenetically controlled approach to understanding proximate transmission pathways in Austronesian cultural diversity. PMID:21199844

  17. Moral Reasoning among HEC Members: An Empirical Evaluation of the Relationship of Theory and Practice in Clinical Ethics Consultation.

    PubMed

    Wasserman, Jason Adam; Stevenson, Shannon Lindsey; Claxton, Cassandra; Krug, Ernest F

    2015-01-01

    In light of the ongoing development and implementation of core competencies in bioethics, it is important to proceed with a clear sense of how bioethics knowledge is utilized in the functioning of hospital ethics committees (HECs). Without such an understanding, we risk building a costly edifice on a foundation that is ambiguous at best. This article examines the empirical relationship between traditional paradigms of bioethics theory and actual decision making by HEC members using survey data from HEC members. The assumption underlying the standardization of qualifications and corresponding call for increased education of HEC members is that they will base imminent case decisions on inculcated knowledge. Our data suggest, however, that HEC members first decide intuitively and then look for justification, thereby highlighting the need to re-examine the pedagogical processes of ethics education in the process of standardizing and improving competencies.

  18. Empirically Supported Treatments in Psychotherapy: Towards an Evidence-Based or Evidence-Biased Psychology in Clinical Settings?

    PubMed Central

    Castelnuovo, Gianluca

    2010-01-01

    The field of research and practice in psychotherapy has been deeply influenced by two different approaches: the empirically supported treatments (ESTs) movement, linked with the evidence-based medicine (EBM) perspective and the “Common Factors” approach, typically connected with the “Dodo Bird Verdict”. About the first perspective, since 1998 a list of ESTs has been established in mental health field. Criterions for “well-established” and “probably efficacious” treatments have arisen. The development of these kinds of paradigms was motivated by the emergence of a “managerial” approach and related systems for remuneration also for mental health providers and for insurance companies. In this article ESTs will be presented underlining also some possible criticisms. Finally complementary approaches, that could add different evidence in the psychotherapy research in comparison with traditional EBM approach, are presented. PMID:21833197

  19. Wertheim's hypothesis on 'highway hypnosis': empirical evidence from a study on motorway and conventional road driving.

    PubMed

    Cerezuela, Gemma Pastor; Tejero, Pilar; Chóliz, Mariano; Chisvert, Mauricio; Monteagudo, M José

    2004-11-01

    This paper aims to study the phenomenon known as 'highway hypnosis' or 'driving without attention mode', which has been defined as a state showing sleepiness signs and attention slip resulting from driving a motor vehicle for a long period in a highly predictable environment with low event occurrence, this being the case with motorways and very familiar roads [Highway hypnosis: a theoretical analysis. In: Gale, A.G., Brown, I.D., Haslegrave, C.M., Moorhead, I., Taylor, S. (Eds.), Vision in Vehicles-III. Elsevier, North-Holland, pp. 467-472]. According to Wertheim's hypothesis on 'highway hypnosis', long-term driving on motorways and conventional roads, e.g. main roads, secondary roads--implies differences in the predictability of the movement pattern of the visual stimulation, in the eye musculature activity and in the type of feedback used in visual information processing (mostly extra-retinal on motorways and retinal and extra-retinal on conventional roads). All this ultimately leads to alertness differences between both road types. Our research is intended to provide empirical evidence from the hypothesis, based on the data recorded during the actual driving experience of a group of subjects on a motorway and a conventional road. We studied whether or not significant alertness differences were found-measured by EEG data relative to time periods of on-target eye-tracking performance--between motorway and conventional road driving. Our results partially support the hypothesis, as drowsiness proved to be higher on motorways than on conventional roads during the final driving period but not during the starting stage, when the opposite trend was noticed. This result could be explained by the fact that during the first driving periods the effects of the stimulus movement predictability had not yet become apparent, since they tend to show after a long drive.

  20. An empirical bayesian method for differential expression studies using one-channel microarray data.

    PubMed

    Lin, Yan; Reynolds, Paul; Feingold, Eleanor

    2003-01-01

    Gene expression microarrays have become powerful tools in many areas of biological and biomedical research. These technologies allow researchers to measure the expression levels of thousands of genes in a tissue or cell sample simultaneously. One of the most common types of microarray experiments is simply an exploratory study to compare two samples (e.g. tumor and normal tissue) and look for a list of genes that might be differentially expressed between the two. Differential expression is typically measured by computing a t-statistic or similar statistic for each gene. The genes are then ranked according to the absolute value of the t-statistic, and the twenty or fifty best candidates might be studied in follow-up experiments. When sample sizes are small, the t-statistic can be problematic, because variances are estimated poorly and the "top 20" list is often dominated by the genes with the lowest variance estimates. Lönnstedt and Speed (2001) proposed an empirical Bayes method for avoiding this problem, and showed that their approach has lower false positive and false negative rates than t-statistic-based methods. However, their method was designed mainly for the two-channel microarray, which produces paired data. It is not suitable for technologies such as one-channel arrays that produce unpaired data. We propose a simplification for Lönnstedt and Speed's method, and then extend it to unpaired data with two or more independent treatments. We demonstrate our method on both simulated and real data. When the number of replicates is small, gene rankings based on our statistic appear to be much more reliable than rankings based on the t-statistic.

  1. Asymptotic scenarios for the proton’s central opacity: An empirical study

    SciTech Connect

    Fagundes, D. A.; Menon, M. J.; Silva, P. V. R. G.

    2015-04-10

    We present a model-independent analysis of the experimental data on the ratio X between the elastic and total cross-sections from pp and p{sup ¯}p scattering in the c.m. energy interval 5 GeV - 8 TeV. Using a novel empirical parametrization for that ratio as a function of the energy and based on theoretical and empirical arguments, we investigate three distinct asymptotic scenarios: either the black-disk (BD) limit or scenarios above and below that limit. Our analysis favors a scenario below the BD, with asymptotic ratio X = 0.36 ± 0.08.

  2. Economic Evaluation alongside Multinational Studies: A Systematic Review of Empirical Studies

    PubMed Central

    Oppong, Raymond; Jowett, Sue; Roberts, Tracy E.

    2015-01-01

    Purpose of the study This study seeks to explore methods for conducting economic evaluations alongside multinational trials by conducting a systematic review of the methods used in practice and the challenges that are typically faced by the researchers who conducted the economic evaluations. Methods A review was conducted for the period 2002 to 2012, with potentially relevant articles identified by searching the Medline, Embase and NHS EED databases. Studies were included if they were full economic evaluations conducted alongside a multinational trial. Results A total of 44 studies out of a possible 2667 met the inclusion criteria. Methods used for the analyses varied between studies, indicating a lack of consensus on how economic evaluation alongside multinational studies should be carried out. The most common challenge appeared to be related to addressing differences between countries, which potentially hinders the generalisability and transferability of results. Other challenges reported included inadequate sample sizes and choosing cost-effectiveness thresholds. Conclusions It is recommended that additional guidelines be developed to aid researchers in this area and that these be based on an understanding of the challenges associated with multinational trials and the strengths and limitations of alternative approaches. Guidelines should focus on ensuring that results will aid decision makers in their individual countries. PMID:26121465

  3. Clinical evidence for Japanese population based on prospective studies--linking clinical trials and clinical practice.

    PubMed

    Ogawa, Hisao; Kojima, Sunao

    2009-10-01

    "Evidence-based medicine (EBM)" implies effective and high quality practice for patients based on well-grounded medical science. The success of clinical trials in Japan is essential to build original evidence specific for Japanese patients. Based on this concept, we have performed several large-scale clinical trials to provide EBM, including the Japanese Antiplatelets Myocardial Infarction Study [JAMIS; clinical improvement in acute myocardial infarction (AMI) patients with antiplatelet therapy], the Japanese beta-Blockers and Calcium Antagonists Myocardial Infarction (JBCMI; comparison of the effects of beta-blockers and calcium antagonists on cardiovascular events in post-AMI patients), a multicenter study for aggressive lipid-lowering strategy by HMG-CoA reductase inhibitors in patients with AMI (MUSASHI; effects of statin therapy on cardiovascular events in patients with AMI), and the Japanese Primary Prevention of Atherosclerosis with Aspirin for Diabetes (JPAD trial; efficacy of low-dose aspirin therapy for primary prevention of atherosclerotic events in type 2 diabetic patients). The results of these prospective studies were directly linked with clinical practice. We have acquired the know-how of large-scale clinical trials; an important point is to have passion for "buildup evidence specific for the Japanese" and to recruit subjects for enrollment after explaining the significance of "clinical trials for the Japanese".

  4. Marketing and clinical trials: a case study

    PubMed Central

    Francis, David; Roberts, Ian; Elbourne, Diana R; Shakur, Haleema; Knight, Rosemary C; Garcia, Jo; Snowdon, Claire; Entwistle, Vikki A; McDonald, Alison M; Grant, Adrian M; Campbell, Marion K

    2007-01-01

    Background Publicly funded clinical trials require a substantial commitment of time and money. To ensure that sufficient numbers of patients are recruited it is essential that they address important questions in a rigorous manner and are managed well, adopting effective marketing strategies. Methods Using methods of analysis drawn from management studies, this paper presents a structured assessment framework or reference model, derived from a case analysis of the MRC's CRASH trial, of 12 factors that may affect the success of the marketing and sales activities associated with clinical trials. Results The case study demonstrates that trials need various categories of people to buy in – hence, to be successful, trialists must embrace marketing strategies to some extent. Conclusion The performance of future clinical trials could be enhanced if trialists routinely considered these factors. PMID:18028537

  5. Lightning and Other Influences On Tropical Tropospheric Ozone: Empirical Studies of Covariation

    NASA Technical Reports Server (NTRS)

    Chatfield, Robert B.; Guan, Hong; Hudson, Robert D.; Witte, Jacquelyne C.

    2003-01-01

    Tropical and subtropical tropospheric ozone are important radiatively active species, with particularly large effects in the upper third of the troposphere. Temporal variability of O3 has proved difficult to simulate day by day in process models. Thus, individual roles of lightning, biomass burning, and other pollution in providing precursor NO(x), radicals, and chain carriers (CO, hydrocarbons) remain unquantified by simulation, and it is theoretically reasonable that individual roles are magnified by a joint synergy. We use wavelet analysis and Burg-algorithm maximum entropy spectral analyses to describe time-scales and correlation of ozone with proxies for processes controlling its concentration. Our empirical studies link time variations apparent in several datasets: the SHADOZ (Southern Hemisphere Additional Ozonesondes) network stations (Nairobi, Fiji), and auxiliary series with power to explain ozone-determining processes, with some interpretation based on the TTO (Tropical Tropospheric Ozone) product derived from TOMS (the Total Ozone Mapping Spectrometer). The auxiliary series are The OTD/LIS(Optical Transient Detector/Lightning Imaging Sensor) measurements of the lightning NO(x) source, the OLR (Outgoing Longwave Radiation)measurement of high-topped clouds, and standard meteorological variables from the United States NCEP (National Centers for Environmental Prediction) and Data Assimilation Office analyses. Concentrating on equatorial ozone, we compare the statistical evidence on the variability of tropospheric ozone. Important variations occur on approximately two-week, two-month (Madden-Julian Oscillation) and annual scales, and relations with OLR suggest controls associated with continental clouds. Hence we are now using the Lightning Imaging Sensor data set to indicate NO(x) sources. We report initial results defining relative roles of the process mentioned affecting O3 using their covariance properties.

  6. Organizational performance, Marketing strategy, and Financial strategic alignment: an empirical study on Iranian pharmaceutical firms

    PubMed Central

    2013-01-01

    Background Strategic Functional-level planning should be aligned with business level and other functional strategies of a company. It is presumed that assimilating the strategies could have positive contribution to business performance, in this regard alignment between marketing strategy and financial strategy seems to be the most important strategies being studied. An empirical work in generic pharmaceutical manufacturing companies for evaluating effect of alignment between these two functions on organizational performance was developed in this paper. Methods All Iranian pharmaceutical generic manufactures listed in Tehran stock market have been tested for period of five years between 2006–2010 and their marketing strategies were determined by using Slater and Olson taxonomy and their financial strategies have been developed by calculating total risk and total return of sample companies for five years based on rate of risk and return in the frame of a 2 × 2 matrix. For the business performance three profitability indices including Q-Tubin (Rate of market value to net asset value), ROA (Return on Asset), ROE (Return on Equity) have been tested. For analysis, a series of one-way ANOVAs as a collection of statistical models within marketing strategies considering financial strategy as independent variable and the three performance measures as dependent variables was used. Results Results show strategic alignment between financial and marketing has significant impact on profitability of company resulting in arise of all three profitability indices. Q tubing’s rate were 2.33,2.09,2.29,2.58 and rate of ROA were 0.21,0.194,0.25,0.22 and rate of ROE were 0.44,0.46,0.45,0.42 for matched strategy types, respectively the rates shown here are more than average meaning that specific type of marketing strategy is fitted with specific type of financial strategy. Conclusion Managers should not consider decisions regarding marketing strategy independently of their financial

  7. The Impact of Excluding Trials from Network Meta-Analyses – An Empirical Study

    PubMed Central

    Zhang, Jing; Yuan, Yiping; Chu, Haitao

    2016-01-01

    Network meta-analysis (NMA) expands the scope of a conventional pairwise meta-analysis to simultaneously compare multiple treatments, which has an inherent appeal for clinicians, patients, and policy decision makers. Two recent reports have shown that the impact of excluding a treatment on NMAs can be substantial. However, no one has assessed the impact of excluding a trial from NMAs, which is important because many NMAs selectively include trials in the analysis. This article empirically examines the impact of trial exclusion using both the arm-based (AB) and contrast-based (CB) approaches, by reanalyzing 20 published NMAs involving 725 randomized controlled trials and 449,325 patients. For the population-averaged absolute risk estimates using the AB approach, the average fold changes across all networks ranged from 1.004 (with standard deviation 0.004) to 1.072 (with standard deviation 0.184); while the maximal fold changes ranged from 1.032 to 2.349. In 12 out of 20 NMAs, a 1.20-fold or larger change is observed in at least one of the population-averaged absolute risk estimates. In addition, while excluding a trial can substantially change the estimated relative effects (e.g., log odds ratios), there is no systematic difference in terms of changes between the two approaches. Changes in treatment rankings are observed in 7 networks and changes in inconsistency are observed in 3 networks. We do not observe correlations between changes in treatment effects, treatment rankings and inconsistency. Finally, we recommend rigorous inclusion and exclusion criteria, logical study selection process, and reasonable network geometry to ensure robustness and generalizability of the results of NMAs. PMID:27926924

  8. Empirical Study on Learners' Self-Efficacy in ESL/EFL Context

    ERIC Educational Resources Information Center

    Shi, Lihong

    2016-01-01

    With the popularity of learner-oriented approach in language teaching, research on learners is gaining more and more importance. This paper attempts to review the empirical researches on self-efficacy in the ESL/EFL settings during the past 10 years with the purpose of depicting the extent to which the self-efficacy research in ESL/EFL has…

  9. Task-Based Language Teaching: An Empirical Study of Task Transfer

    ERIC Educational Resources Information Center

    Benson, Susan D.

    2016-01-01

    Since the 1980s, task-based language teaching (TBLT) has enjoyed considerable interest from researchers of second language acquisition (SLA), resulting in a growing body of empirical evidence to support how and to what extent this approach can promote language learning. Although transferability and generalizability are critical assumptions for…

  10. Indigenous People and Poverty in Latin America: An Empirical Analysis. World Bank Regional and Sectoral Studies.

    ERIC Educational Resources Information Center

    Psacharopoulos, George, Ed.; Patrinos, Harry Anthony, Ed.

    The indigenous peoples of Latin America live in conditions of extreme poverty. This book uses empirical data from national survey sources to determine the extent of poverty among Latin American indigenous populations; to compare indigenous and nonindigenous populations with regard to socioeconomic status, living conditions, educational attainment,…

  11. Teachers' Professional Competences: What Has Drama in Education to Offer? An Empirical Study in Greece

    ERIC Educational Resources Information Center

    Papavassiliou-Alexiou, Ioanna; Zourna, Christina

    2016-01-01

    This article examines how the training in and use of Drama in Education (DiE) affects the development of teachers' professional skills. The article draws on data from broader empirical qualitative research about the impact of DiE on personal, social and professional development of Greek secondary school teachers. The research was carried out using…

  12. Factors Influencing Beliefs for Adoption of a Learning Analytics Tool: An Empirical Study

    ERIC Educational Resources Information Center

    Ali, Liaqat; Asadi, Mohsen; Gasevic, Dragan; Jovanovic, Jelena; Hatala, Marek

    2013-01-01

    Present research and development offer various learning analytics tools providing insights into different aspects of learning processes. Adoption of a specific tool for practice is based on how its learning analytics are perceived by educators to support their pedagogical and organizational goals. In this paper, we propose and empirically validate…

  13. The Formula Approach to Library Size: An Empirical Study of Its Efficacy in Evaluating Research Libraries

    ERIC Educational Resources Information Center

    McInnis, R. Marvin

    1972-01-01

    Formula approaches to the determination of adequate library size, especially along lines developed by Clapp and Jordan, have in recent years become a significant element of the librarian's arsenal. In this article the possibilities of using statistical regression analysis to provide such an empirical analysis are reviewed. (6 references)…

  14. Threats and Aggression Directed at Soccer Referees: An Empirical Phenomenological Psychological Study

    ERIC Educational Resources Information Center

    Friman, Margareta; Nyberg, Claes; Norlander, Torsten

    2004-01-01

    A descriptive qualitative analysis of in-depth interviews involving seven provincial Soccer Association referees was carried out in order to find out how referees experience threats and aggression directed to soccer referees. The Empirical Phenomenological Psychological method (EPP-method) was used. The analysis resulted in thirty categories which…

  15. Understanding Participation in E-Learning in Organizations: A Large-Scale Empirical Study of Employees

    ERIC Educational Resources Information Center

    Garavan, Thomas N.; Carbery, Ronan; O'Malley, Grace; O'Donnell, David

    2010-01-01

    Much remains unknown in the increasingly important field of e-learning in organizations. Drawing on a large-scale survey of employees (N = 557) who had opportunities to participate in voluntary e-learning activities, the factors influencing participation in e-learning are explored in this empirical paper. It is hypothesized that key variables…

  16. Empirical Studies of Interactions of Semantic Roles: The Agent and Patient in Mandarin Chinese

    ERIC Educational Resources Information Center

    Yue, Kun

    2010-01-01

    This dissertation investigates the interaction between form and function in Mandarin Chinese by empirically examining the interactions of core semantic roles (Agent and Patient) and the syntactic representation of those interactions in semantically transitive events. First, I demonstrate that syntactic structures and functions are intertwined with…

  17. Sick but yet at work. An empirical study of sickness presenteeism

    PubMed Central

    Aronsson, G.; Gustafsson, K.; Dallner, M.

    2000-01-01

    STUDY OBJECTIVE—The study is an empirical investigation of sickness presenteeism in relation to occupation, irreplaceability, ill health, sickness absenteeism, personal income, and slimmed down organisation.
DESIGN—Cross sectional design.
SETTING—Swedish workforce.
PARTICIPANTS—The study group comprised a stratified subsample of 3801 employed persons working at the time of the survey, interviewed by telephone in conjunction with Statistics Sweden's labour market surveys of August and September 1997. The response rate was 87 per cent.
MAIN RESULTS—A third of the persons in the total material reported that they had gone to work two or more times during the preceding year despite the feeling that, in the light of their perceived state of health, they should have taken sick leave. The highest presenteeism is largely to be found in the care and welfare and education sectors (nursing and midwifery professionals, registered nurses, nursing home aides, compulsory school teachers and preschool/primary educationalists. All these groups work in sectors that have faced personnel cutbacks during the 1990s). The risk ratio (odds ratio (OR)) for sickness presenteeism in the group that has to re-do work remaining after a period of absence through sickness is 2.29 (95% CI 1.79, 2.93). High proportions of persons with upper back/neck pain and fatigue/slightly depressed are among those with high presenteeism (p< 0.001). Occupational groups with high sickness presenteeism show high sickness absenteeism (ρ = 0.38; p<.01) and the hypothesis on level of pay and sickness presenteeism is also supported (ρ = −0.22; p<0.01).
CONCLUSIONS—Members of occupational groups whose everyday tasks are to provide care or welfare services, or teach or instruct, have a substantially increased risk of being at work when sick. The link between difficulties in replacement or finding a stand in and sickness presenteeism is confirmed by study results. The categories with

  18. A prospective, randomized study of empirical antifungal therapy for the treatment of chemotherapy-induced febrile neutropenia in children.

    PubMed

    Caselli, Désirée; Cesaro, Simone; Ziino, Ottavio; Ragusa, Pietro; Pontillo, Alfredo; Pegoraro, Anna; Santoro, Nicola; Zanazzo, Giulio; Poggi, Vincenzo; Giacchino, Mareva; Livadiotti, Susanna; Melchionda, Fraia; Chiodi, Marcello; Aricò, Maurizio

    2012-07-01

    Given that the rationale for empirical antifungal therapy in neutropenic children is limited and based on adult patient data, we performed a prospective, randomized, controlled trial that evaluated 110 neutropenic children with persistent fever. Those at high risk for invasive fungal infections (IFI) received caspofungin (Arm C) or liposomal amphotericinB (Arm B); those with a lower risk were randomized to receive Arm B, C, or no antifungal treatment (Arm A). Complete response to empirical antifungal therapy was achieved in 90/104 patients (86·5%): 48/56 at high risk (85·7%) [88·0% in Arm B; 83·9% in Arm C (P = 0·72)], and 42/48 at low risk (87·5%) [87·5% in control Arm A, 80·0% Arm B, 94·1% Arm C; (P = 0·41)]. None of the variables tested by multiple logistic regression analysis showed a significant effect on the probability to achieve complete response. IFI was diagnosed in nine patients (8·2%, 95% confidence interval, 3·8-15·0). This randomized controlled study showed that empirical antifungal therapy was of no advantage in terms of survival without fever and IFI in patients aged <18 years and defined with low risk of IFI. Higher risk patients, including those with relapsed cancer, appear to be the target for empirical antifungal therapy during protracted febrile neutropenia.

  19. An Automated System for Generating Situation-Specific Decision Support in Clinical Order Entry from Local Empirical Data

    ERIC Educational Resources Information Center

    Klann, Jeffrey G.

    2011-01-01

    Clinical Decision Support is one of the only aspects of health information technology that has demonstrated decreased costs and increased quality in healthcare delivery, yet it is extremely expensive and time-consuming to create, maintain, and localize. Consequently, a majority of health care systems do not utilize it, and even when it is…

  20. Computer-Assisted Language Intervention Using Fast ForWord: Theoretical and Empirical Considerations for Clinical Decision-Making.

    ERIC Educational Resources Information Center

    Gillam, Ronald B.

    1999-01-01

    This article critiques the theoretical basis of the Fast ForWord program, a computer-assisted language intervention program for children with language-learning impairments. It notes undocumented treatment outcomes and questions the clinical methods associated with the procedures. Fifteen cautionary statements are provided that clinicians may want…

  1. Clinical TVA-based studies: a general review

    PubMed Central

    Habekost, Thomas

    2015-01-01

    In combination with whole report and partial report tasks, the theory of visual attention (TVA) can be used to estimate individual differences in five basic attentional parameters: the visual processing speed, the storage capacity of visual short-term memory, the perceptual threshold, the efficiency of top–down selectivity, and the spatial bias of attentional weighting. TVA-based assessment has been used in about 30 studies to investigate attentional deficits in a range of neurological and psychiatric conditions: (a) neglect and simultanagnosia, (b) reading disturbances, (c) aging and neurodegenerative diseases, and most recently (d) neurodevelopmental disorders. The article introduces TVA based assessment, discusses its methodology and psychometric properties, and reviews the progress made in each of the four research fields. The empirical results demonstrate the general usefulness of TVA-based assessment for many types of clinical neuropsychological research. The method’s most important qualities are cognitive specificity and theoretical grounding, but it is also characterized by good reliability and sensitivity to minor deficits. The review concludes by pointing to promising new areas for clinical TVA-based research. PMID:25852607

  2. An empirical study of the nuclear explosion-induced lightning seen on IVY-MIKE

    NASA Astrophysics Data System (ADS)

    Colvin, J. D.; Mitchell, C. K.; Greig, J. R.; Murphy, D. P.; Pechacek, R. E.; Raleigh, M.

    1987-05-01

    We report the results of a unique study of the lightninglike phenomena that were seen to accompany the MIKE shot of operation IVY on October 31 1952. MIKE was a thermonuclear surface burst yielding 10.4 MT, which took place on Enewetak Atoll. During the period of approximately 10 ms after detonation, five discrete luminous channels were seen to start from the ground or sea surface at a distance of approximately 1 km from the burst point and to grow up into the clouds. We have reexamined the original photographic records of IVY-MIKE, obtaining effective brightnesses (optical powers per unit length) for the luminous channels at different altitudes as functions of time. The absolute calibration for the MIKE records was deduced by comparison with the photographic records of other events of that era, laboratory measurements of film sensitivity, and use of atmospheric transmission data taken just prior to the MIKE event. Errors in this analysis lead to an uncertainty of a factor of ˜2 in the brightnesses of the luminous channels. In the laboratory we have used laser-guided electric discharges to create long (100 cm), arclike plasma channels to simulate the observed luminous channels and to allow determination of an empirical relation between the brightness of the channel and the electric current flowing in the channel. These laboratory discharges had peak currents up to 100 kA and periods of ˜2 ms. Spectroscopic analysis showed that the luminous channels consisted primarily of normal air plasma with typical ground-level contaminants. Photographic studies showed that these long-duration discharges are unstable to the m = 1 magnetohydrodynamic (MHD) instability and become severely distorted in less than 1 ms. By direct comparison of the luminous channels seen at MIKE and the laboratory discharges, we deduce: (1) the peak current in the prominent (brightest) channel at MIKE was between 200 and 600 kA. Here the most likely value of the peak current was 250±50 kA, but

  3. A Conceptual and Empirical Review of the Meaning, Measurement, Development, and Teaching of Intervention Competence in Clinical Psychology

    PubMed Central

    Barber, Jacques P.

    2009-01-01

    Through the course of this paper we discuss several fundamental issues related to the intervention competence of psychologists. Following definitional clarification and proposals for more strictly distinguishing competence from adherence, we interpret Dreyfus and Dreyfus’s (1986) five stage theory of competence development (from novice to expert) within a strictly clinical framework. Existing methods of competence assessment are then evaluated, and we argue for the use of new and multiple assessment modalities. Next, we utilize the previous sections as a foundation to propose methods for training and evaluating competent psychologists. Lastly, we discuss several potential impediments to large scale competence assessment and education, such as the heterogeneity of therapeutic orientations and what could be termed a lack of transparency in clinical training. PMID:18952334

  4. A study on the use of empirical models to predict the formation of acrylamide in potato crisps.

    PubMed

    Knol, Jeroen J; Viklund, Gunilla A I; Linssen, Jozef P H; Sjöholm, Ingegerd M; Skog, Kerstin I; van Boekel, Martinus A J S

    2008-03-01

    The formation of acrylamide in potato crisps was fitted by empirical mathematical models. Potato slices were fried under the same experimental conditions for different times. Besides the content of precursors in the raw potato slices, acrylamide and water content in the potato crisps were quantified after predetermined times (2-6 min). The temperature developments in the surrounding oil and outer cell layer of the potato slices were monitored, giving more insight in the frying process and making future comparisons between studies possible. The pattern found for the formation of acrylamide, which was similar to earlier studies, was fitted to three empirical models. Statistical methods were used to compare the performance of the models, with the "Logistic-Exponential" and "Empirical" model performing equally well. The obtained model parameters were in the range of earlier reported studies, although this comparison is not unequivocal as the experimental conditions differed between studies. The precision of parameter estimates was problematic; this should be improved by better experimental design. Nevertheless, the approach of this study will make it possible to truly compare acrylamide formation patterns and model parameters in the future, with the ability to develop a tool to predict acrylamide formation in potato crisps.

  5. Empirical Studies of the Effect of Flood Risk on Housing Prices.

    DTIC Science & Technology

    1998-02-01

    Principles and Guidelines (P&G)for water resources planning, which required a multi -objective analysis of tradeoffs among national and regional...Standards (P&S) and later, Principles and Guidelines (P&G)for water resources planning, which required a multi -objective analysis of tradeoffs among...to the overall price. The models are empirically assessed with multi -variate regression models where sale price is the dependent variable and the

  6. An empirical, graphical, and analytical study of the relationship between vegetation indices. [derived from LANDSAT data

    NASA Technical Reports Server (NTRS)

    Lautenschlager, L.; Perry, C. R., Jr. (Principal Investigator)

    1981-01-01

    The development of formulae for the reduction of multispectral scanner measurements to a single value (vegetation index) for predicting and assessing vegetative characteristics is addressed. The origin, motivation, and derivation of some four dozen vegetation indices are summarized. Empirical, graphical, and analytical techniques are used to investigate the relationships among the various indices. It is concluded that many vegetative indices are very similar, some being simple algebraic transforms of others.

  7. Forecasting Energy Market Contracts by Ambit Processes: Empirical Study and Numerical Results

    PubMed Central

    Di Persio, Luca; Marchesan, Michele

    2014-01-01

    In the present paper we exploit the theory of ambit processes to develop a model which is able to effectively forecast prices of forward contracts written on the Italian energy market. Both short-term and medium-term scenarios are considered and proper calibration procedures as well as related numerical results are provided showing a high grade of accuracy in the obtained approximations when compared with empirical time series of interest. PMID:27437500

  8. An Empirical Study of the Wound Effects on Sap Flow Measured with Thermal Dissipation Probes

    NASA Astrophysics Data System (ADS)

    Wiedemann, A.; Marañón-Jiménez, S.; Herbst, M.; Cuntz, M.; Rebmann, C.

    2014-12-01

    Sap flow sensors are common to assess the contribution of tree transpiration to ecosystem evapotranspiration (ET). Thermal dissipation (TD) is one of the most popular methods for sap measurements but the insertion of TD probes in the tree stems imply wounding of the wood tissue and a consequent alteration of the sap flow. But the determination of sap flux density (SFD) is based on an empirical function developed for freshly drilled holes and it does hence not account for the wound effect. Here we investigate the effect of wound healing on sap flow measurements with TD probes. Our objectives were (1) the establishment of correction factors to account for the wound effect and (2) the determination of the point in time after installation when the correction factors become applicable. For that we performed an experiment in which TD probes were installed successively in diffuse- and ring-porous trees (Fagus sylvatica and Quercus petraea, resp.) during the growing season. The trees were logged in fall and additional sensors were installed afterwards in the logged stems. SFDs measured by the different TD sensors were compared with gravimetric estimates in the laboratory. Gravimetric flow compared well with SFD estimates from freshly installed sensors without wound formation, with only a slight underestimation by the TDs. In contrast, older sensors, submitted to wound reactions, underestimated SFD by up to 40%. However, sensors with 5, 11 and 22 week old wounds showed no significant differences, which implies that wound healing occurs in the first weeks after scission. Similar sap flow underestimations due to wound effects were observed in both species, oak and beech. This study highlights the relevance of accounting for tree wound reactions for accurate estimation of tree transpiration based on thermal dissipation sensors. We provide a correction factor for the classical Granier TD sensors that can be used from the first weeks after installation in similar species. This

  9. The study and development of the empirical correlations equation of natural convection heat transfer on vertical rectangular sub-channels

    NASA Astrophysics Data System (ADS)

    Kamajaya, Ketut; Umar, Efrizon; Sudjatmi, K. S.

    2012-06-01

    This study focused on natural convection heat transfer using a vertical rectangular sub-channel and water as the coolant fluid. To conduct this study has been made pipe heaters are equipped with thermocouples. Each heater is equipped with five thermocouples along the heating pipes. The diameter of each heater is 2.54 cm and 45 cm in length. The distance between the central heating and the pitch is 29.5 cm. Test equipment is equipped with a primary cooling system, a secondary cooling system and a heat exchanger. The purpose of this study is to obtain new empirical correlations equations of the vertical rectangular sub-channel, especially for the natural convection heat transfer within a bundle of vertical cylinders rectangular arrangement sub-channels. The empirical correlation equation can support the thermo-hydraulic analysis of research nuclear reactors that utilize cylindrical fuel rods, and also can be used in designing of baffle-free vertical shell and tube heat exchangers. The results of this study that the empirical correlation equations of natural convection heat transfer coefficients with rectangular arrangement is Nu = 6.3357 (Ra.Dh/x)0.0740.

  10. Reversal of dental fluorosis: A clinical study

    PubMed Central

    Mehta, Dhaval N.; Shah, Jigna

    2013-01-01

    Aim: This study was conducted to evaluate the clinical reversal of dental fluorosis with various combinations of calcium, vitamin D3, and ascorbic acid, along with changes in levels of certain biochemical parameters concerned with dental fluorosis. The role of fluoride level of drinking water in the etiology of dental fluorosis and the prevalence of dental fluorosis in both dentitions and teeth were also assessed. Materials and Methods: A total number of 50 patients with clinical features of dental fluorosis without trauma and any adverse habits were selected. Of these, in 30 co-operative patients, estimation of water fluoride level and pretreatment and post-treatment serum and urine fluoride levels were done with ion selective electrode method. The selected 30 patients were divided into three groups, that is, group A, group B, and group C, and were given various combinations of medications like calcium with vitamin D3 supplements, ascorbic acid with vitamin D3 supplements, and chlorhexidine mouthwash (placebo) for three months, respectively. These 30 patients were assessed for any change in the clinical grading of dental fluorosis. Results: No change in clinical grading of dental fluorosis was noted. Considerable reduction in serum and urine fluoride levels was noted in both group A and group B patients. Dental fluorosis was noted in permanent teeth more commonly than deciduous teeth, and permanent maxillary central incisors had the highest prevalence rate. Conclusion: This study comprises only 30 patients with three months of follow-up. So, this sample of patients and duration of follow-up period are conclusive to observe changes in biochemical parameters but not sufficient to observe changes in clinical grading. PMID:23633850

  11. Managing the Services Supply Chain in the Department of Defense: An Empirical Study of Current Management Practices

    DTIC Science & Technology

    2009-08-19

    Supply Chain in the Department of Defense: An Empirical Study of Current Management Practices 19 August 2009 by Dr. Aruna U. Apte, Assistant Professor Dr. Uday M. Apte, Professor, and Dr. Rene G. Rendon, Associate Professor Graduate School of Business & Public Policy Naval Postgraduate School Naval Postgraduate School Monterey, California Daniel T. Oliver Leonard A. Ferrari President Provost The Acquisition Chair, Graduate School of Business & Public Policy, Naval Postgraduate School

  12. Biosimilars entering the clinic without animal studies

    PubMed Central

    van Aerts, Leon AGJM; De Smet, Karen; Reichmann, Gabriele; van der Laan, Jan Willem; Schneider, Christian K

    2014-01-01

    The concept of biosimilars has spread from Europe to other regions throughout the world, and many regions have drafted regulatory guidelines for their development. Recently, a paradigm shift in regulatory thinking on the non-clinical development of biosimilars has emerged in Europe: In vivo testing should follow a step-wise approach rather than being performed by default. To not require animal testing at all in some instances can well be seen as a revolutionary, but science-based, step. Here, we describe the internal discussions that led to this paradigm shift. The mainstay for the establishment of biosimilarity is the pharmaceutical comparability based on extensive physicochemical and biological characterization. Pharmacodynamic comparability can be evaluated in in vitro assays, whereas pharmacokinetic comparability is best evaluated in clinical studies. It is considered highly unlikely that new safety issues would arise when comparability has been demonstrated based on physicochemical and in vitro comparative studies. PMID:25517301

  13. Empirical power and sample size calculations for cluster-randomized and cluster-randomized crossover studies.

    PubMed

    Reich, Nicholas G; Myers, Jessica A; Obeng, Daniel; Milstone, Aaron M; Perl, Trish M

    2012-01-01

    In recent years, the number of studies using a cluster-randomized design has grown dramatically. In addition, the cluster-randomized crossover design has been touted as a methodological advance that can increase efficiency of cluster-randomized studies in certain situations. While the cluster-randomized crossover trial has become a popular tool, standards of design, analysis, reporting and implementation have not been established for this emergent design. We address one particular aspect of cluster-randomized and cluster-randomized crossover trial design: estimating statistical power. We present a general framework for estimating power via simulation in cluster-randomized studies with or without one or more crossover periods. We have implemented this framework in the clusterPower software package for R, freely available online from the Comprehensive R Archive Network. Our simulation framework is easy to implement and users may customize the methods used for data analysis. We give four examples of using the software in practice. The clusterPower package could play an important role in the design of future cluster-randomized and cluster-randomized crossover studies. This work is the first to establish a universal method for calculating power for both cluster-randomized and cluster-randomized clinical trials. More research is needed to develop standardized and recommended methodology for cluster-randomized crossover studies.

  14. A Systematic Review of CPAP Adherence Across Age Groups: Clinical and Empiric Insights for Developing CPAP Adherence Interventions

    PubMed Central

    Sawyer, A.M.; Gooneratne, N.; Marcus, C.L.; Ofer, D.; Richards, K.C.; Weaver, T.E.

    2011-01-01

    Continuous positive airway pressure (CPAP) is a highly efficacious treatment for obstructive sleep apnea (OSA) but adherence to the treatment limits its overall effectiveness across all age groups of patients. Factors that influence adherence to CPAP include disease and patient characteristics, treatment titration procedures, technological device factors and side effects, and psychological and social factors. These influential factors have guided the development of interventions to promote CPAP adherence. Various intervention strategies have been described and include educational, technological, psychosocial, pharmacological, and multi-dimensional approaches. Though evidence to date has led to innovative strategies that address adherence in CPAP-treated children, adults, and older adults, significant opportunities exist to develop and test interventions that are clinically applicable, specific to subgroups of patients likely to demonstrate poor adherence, and address the multifactorial nature of CPAP adherence. The translation of CPAP adherence promotion interventions to clinical practice is imperative to improve health and functional outcomes in all persons with CPAP-treated OSA. PMID:21652236

  15. A systematic review of CPAP adherence across age groups: clinical and empiric insights for developing CPAP adherence interventions.

    PubMed

    Sawyer, Amy M; Gooneratne, Nalaka S; Marcus, Carole L; Ofer, Dafna; Richards, Kathy C; Weaver, Terri E

    2011-12-01

    Continuous positive airway pressure (CPAP) is a highly efficacious treatment for obstructive sleep apnea (OSA) but adherence to the treatment limits its overall effectiveness across all age groups of patients. Factors that influence adherence to CPAP include disease and patient characteristics, treatment titration procedures, technological device factors and side effects, and psychological and social factors. These influential factors have guided the development of interventions to promote CPAP adherence. Various intervention strategies have been described and include educational, technological, psychosocial, pharmacological, and multi-dimensional approaches. Though evidence to date has led to innovative strategies that address adherence in CPAP-treated children, adults, and older adults, significant opportunities exist to develop and test interventions that are clinically applicable, specific to sub-groups of patients likely to demonstrate poor adherence, and address the multi-factorial nature of CPAP adherence. The translation of CPAP adherence promotion interventions to clinical practice is imperative to improve health and functional outcomes in all persons with CPAP-treated OSA.

  16. The magnitude of hydraulic redistribution by plant roots: a review and synthesis of empirical and modeling studies.

    PubMed

    Neumann, Rebecca B; Cardon, Zoe G

    2012-04-01

    Hydraulic redistribution (HR) - the movement of water from moist to dry soil through plant roots - occurs worldwide within a range of different ecosystems and plant species. The proposed ecological and hydrologic impacts of HR include increasing dry-season transpiration and photosynthetic rates, prolonging the life span of fine roots and maintaining root-soil contact in dry soils, and moving rainwater down into deeper soil layers where it does not evaporate. In this review, we compile estimates of the magnitude of HR from ecosystems around the world, using representative empirical and modeling studies from which we could extract amounts of water redistributed by plant root systems. The reported average magnitude of HR varies by nearly two orders of magnitude across ecosystems, from 0.04 to 1.3 mm H(2)O d(-1) in the empirical literature, and from 0.1 to 3.23 mm H(2)O d(-1) in the modeling literature. Using these synthesized data, along with other published studies, we examine this variation in the magnitude of upward and downward HR, considering effects of plant, soil and ecosystem characteristics, as well as effects of methodological details (in both empirical and modeling studies) on estimates of HR. We take both ecological and hydrologic perspectives.

  17. pLARmEB: integration of least angle regression with empirical Bayes for multilocus genome-wide association studies.

    PubMed

    Zhang, J; Feng, J-Y; Ni, Y-L; Wen, Y-J; Niu, Y; Tamba, C L; Yue, C; Song, Q; Zhang, Y-M

    2017-03-15

    Multilocus genome-wide association studies (GWAS) have become the state-of-the-art procedure to identify quantitative trait nucleotides (QTNs) associated with complex traits. However, implementation of multilocus model in GWAS is still difficult. In this study, we integrated least angle regression with empirical Bayes to perform multilocus GWAS under polygenic background control. We used an algorithm of model transformation that whitened the covariance matrix of the polygenic matrix K and environmental noise. Markers on one chromosome were included simultaneously in a multilocus model and least angle regression was used to select the most potentially associated single-nucleotide polymorphisms (SNPs), whereas the markers on the other chromosomes were used to calculate kinship matrix as polygenic background control. The selected SNPs in multilocus model were further detected for their association with the trait by empirical Bayes and likelihood ratio test. We herein refer to this method as the pLARmEB (polygenic-background-control-based least angle regression plus empirical Bayes). Results from simulation studies showed that pLARmEB was more powerful in QTN detection and more accurate in QTN effect estimation, had less false positive rate and required less computing time than Bayesian hierarchical generalized linear model, efficient mixed model association (EMMA) and least angle regression plus empirical Bayes. pLARmEB, multilocus random-SNP-effect mixed linear model and fast multilocus random-SNP-effect EMMA methods had almost equal power of QTN detection in simulation experiments. However, only pLARmEB identified 48 previously reported genes for 7 flowering time-related traits in Arabidopsis thaliana.Heredity advance online publication, 15 March 2017; doi:10.1038/hdy.2017.8.

  18. Extended Schema Mode conceptualizations for specific personality disorders: an empirical study.

    PubMed

    Bamelis, Lotte L M; Renner, Fritz; Heidkamp, David; Arntz, Arnoud

    2011-02-01

    The aim of this study was to investigate newly formulated schema mode models for cluster-C, paranoid, histrionic and narcissistic personality disorders. In order to assess 18 hypothesized modes, the Schema Mode Inventory (SMI) was modified into the SMI-2. The SMI-2 was administered to a sample of 323 patients (with a main diagnosis on one of the PDs mentioned) and 121 nonpatients. The SMI-2 was successful in distinguishing patients and controls. Newly formulated modes proved to be appropriate for histrionic, avoidant, and dependent PD. The modification of the Overcontroller mode into the Perfectionistic and Suspicious Overcontroller mode was valuable for characterizing paranoid and obsessive-compulsive PD. The results support recent theoretical developments in Schema Therapy, and are useful for application in clinical practice.

  19. Aetiopathological and clinical study of erythroderma.

    PubMed

    Prakash, B V S; Sirisha, N L; Satyanarayana, V V V; Sridevi, L; Ramachandra, B V

    2009-02-01

    Erythoderma first described by Hebra in 1868 is a reaction pattern, characterised by generalised and confluent erythema with desquamation affecting more than 90% of body surface and is usually accompanied by systemic manifestation including some metabolic changes. Tile study was envisaged to assess their profile of aetiology, clinical features and to correlate with histopathological findings. Twenty-four patients (18 males and 6 females) with erythroderma were considered for the study. All patients were hospitalised, detailed history was taken and were subjected to relevant investigations--haemogram, serum proteins, liver and renal function tests, routine and microscopic urine tests, HIV screening, x-ray chest, ultrasound abdomen, FNAC of enlarged lymph nodes and skin biopsy. The age group affected ranged between 7 and 70 years, peak incidence between 50 and 60 years. The male to female ratio was 3:1. Scaling, erythema and pruritus were predominant clinical manifestations. In 12 clinically suspected psoriatic erythroderma, only in 6 cases the histopathological features were correlated to psoriasis and remaining showed non-specific chronic dermatitis. Two patients were found to be HIV-positive. There is good clinicopathological correlation in erythroderma caused by lichen planus, atopic dermatitis, seborroeic dermatitis, non-bullous congenital ichthyosiform erythroderma. Drugs were found to be aetiological factor in 3 cases. The study was conducted to assess variations in clinical, aetiological and histopathological profile of erythroderma. The present series had high percentage of erythroderma secondary to preexisting dermatoses. The onset of disease was insidious except in drug-induced erythroderma where it was acute.

  20. Defining Empirically Based Practice.

    ERIC Educational Resources Information Center

    Siegel, Deborah H.

    1984-01-01

    Provides a definition of empirically based practice, both conceptually and operationally. Describes a study of how research and practice were integrated in the graduate social work program at the School of Social Service Administration, University of Chicago. (JAC)

  1. Computer-Assisted Language Intervention Using Fast ForWord®: Theoretical and Empirical Considerations for Clinical Decision-Making.

    PubMed

    Gillam, Ronald B

    1999-10-01

    A computer-assisted language intervention program called Fast ForWord® (Scientific Learning Corporation, 1998) has received a great deal of attention at professional meetings and in the popular media. Newspaper and magazine articles about this program contain statements like, "On average, after only 6 to 7 weeks of training, language-learning impaired children ages 4 to 12 showed improvement of more than one and a half years in speech processing and language ability." (Scientific Learning Corporation, 1997). Are the claims that are being made about this intervention approach just a matter of product promotion, or is this really a scientifically proven remedy for language-learning impairments? This article critiques the theoretical basis of Fast ForWord®, the documented treatment outcomes, and the clinical methods associated with the procedure. Fifteen cautionary statements are provided that clinicians may want to consider before they recommend Fast ForWord® intervention for the children they serve.

  2. Comparative approaches from empirical to mechanistic simulation modelling in Land Evaluation studies

    NASA Astrophysics Data System (ADS)

    Manna, P.; Basile, A.; Bonfante, A.; Terribile, F.

    2009-04-01

    The Land Evaluation (LE) comprise the evaluation procedures to asses the attitudes of the land to a generic or specific use (e.g. biomass production). From local to regional and national scale the approach to the land use planning should requires a deep knowledge of the processes that drive the functioning of the soil-plant-atmosphere system. According to the classical approaches the assessment of attitudes is the result of a qualitative comparison between the land/soil physical properties and the land use requirements. These approaches have a quick and inexpensive applicability; however, they are based on empirical and qualitative models with a basic knowledge structure specifically built for a specific landscape and for the specific object of the evaluation (e.g. crop). The outcome from this situation is the huge difficulties in the spatial extrapolation of the LE results and the rigidity of the system. Modern techniques instead, rely on the application of mechanistic and quantitative simulation modelling that allow a dynamic characterisation of the interrelated physical and chemical processes taking place in the soil landscape. Moreover, the insertion of physical based rules in the LE procedure may make it less difficult in terms of both extending spatially the results and changing the object (e.g. crop species, nitrate dynamics, etc.) of the evaluation. On the other side these modern approaches require high quality and quantity of input data that cause a significant increase in costs. In this scenario nowadays the LE expert is asked to choose the best LE methodology considering costs, complexity of the procedure and benefits in handling a specific land evaluation. In this work we performed a forage maize land suitability study by comparing 9 different methods having increasing complexity and costs. The study area, of about 2000 ha, is located in North Italy in the Lodi plain (Po valley). The range of the 9 employed methods ranged from standard LE approaches to

  3. Characteristics of German hospitals adopting health IT systems - results from an empirical study.

    PubMed

    Liebe, Jan-David; Egbert, Nicole; Frey, Andreas; Hübner, Ursula

    2011-01-01

    Hospital characteristics that facilitate IT adoption have been described by the literature extensively, however with controversial results. The aim of this study therefore is to draw a set of the most important variables from previous studies and include them in a combined analysis for testing their contribution as single factors and their interactions. Total number of IT systems installed and number of clinical IT systems in the hospital were used as criterion variables. Data from a national survey of German hospitals served as basis. Based on a stepwise multiple regression analysis four variables were identified to significantly explain the degree of IT adoption (60% explained variance): 1) hospital size, 2) IT department, 3) reference customer and 4) ownership (private vs. public). Our results replicate previous findings with regard to hospital size and ownership. In addition our study emphasizes the importance of a reliable internal structure for IT projects (existence of an IT department) and the culture of testing and installing most recent IT products (being a reference customer). None of the interactions between factors was significant.

  4. Clinical cardiac regenerative studies in children

    PubMed Central

    Pavo, Imre J; Michel-Behnke, Ina

    2017-01-01

    Although the incidence of pediatric heart failure is low, the mortality is relatively high, with severe clinical symptoms requiring repeated hospitalization or intensive care treatment in the surviving patients. Cardiac biopsy specimens have revealed a higher number of resident human cardiac progenitor cells, with greater proliferation and differentiation capacity, in the neonatal period as compared with adults, demonstrating the regeneration potential of the young heart, with rising interest in cardiac regeneration therapy in critically ill pediatric patients. We review here the available literature data, searching the MEDLINE, Google Scholar and EMBASE database for completed, and www.clinicaltrials.gov homepage for ongoing studies involving pediatric cardiac regeneration reports. Because of difficulties conducting randomized blinded clinical trials in pediatric patients, mostly case reports or cohort studies with a limited number of individuals have been published in the field of pediatric regenerative cardiology. The majority of pediatric autologous cell transplantations into the cardiac tissue have been performed in critically ill children with severe or terminal heart failure. Congenital heart disease, myocarditis, and idiopathic hypertrophic or dilated cardiomyopathy leading to congestive heart failure are some possible areas of interest for pediatric cardiac regeneration therapy. Autologous bone marrow mononuclear cells, progenitor cells, or cardiospheres have been applied either intracoronary or percutaneously intramyocardially in severely ill children, leading to a reported clinical benefit of cell-based cardiac therapies. In conclusion, compassionate use of autologous stem cell administration has led to at least short-term improvement in heart function and clinical stability in the majority of the critically ill pediatric patients. PMID:28289528

  5. Clinical cardiac regenerative studies in children.

    PubMed

    Pavo, Imre J; Michel-Behnke, Ina

    2017-02-26

    Although the incidence of pediatric heart failure is low, the mortality is relatively high, with severe clinical symptoms requiring repeated hospitalization or intensive care treatment in the surviving patients. Cardiac biopsy specimens have revealed a higher number of resident human cardiac progenitor cells, with greater proliferation and differentiation capacity, in the neonatal period as compared with adults, demonstrating the regeneration potential of the young heart, with rising interest in cardiac regeneration therapy in critically ill pediatric patients. We review here the available literature data, searching the MEDLINE, Google Scholar and EMBASE database for completed, and www.clinicaltrials.gov homepage for ongoing studies involving pediatric cardiac regeneration reports. Because of difficulties conducting randomized blinded clinical trials in pediatric patients, mostly case reports or cohort studies with a limited number of individuals have been published in the field of pediatric regenerative cardiology. The majority of pediatric autologous cell transplantations into the cardiac tissue have been performed in critically ill children with severe or terminal heart failure. Congenital heart disease, myocarditis, and idiopathic hypertrophic or dilated cardiomyopathy leading to congestive heart failure are some possible areas of interest for pediatric cardiac regeneration therapy. Autologous bone marrow mononuclear cells, progenitor cells, or cardiospheres have been applied either intracoronary or percutaneously intramyocardially in severely ill children, leading to a reported clinical benefit of cell-based cardiac therapies. In conclusion, compassionate use of autologous stem cell administration has led to at least short-term improvement in heart function and clinical stability in the majority of the critically ill pediatric patients.

  6. Efficient management of marine resources in conflict: an empirical study of marine sand mining, Korea.

    PubMed

    Kim, Tae-Goun

    2009-10-01

    This article develops a dynamic model of efficient use of exhaustible marine sand resources in the context of marine mining externalities. The classical Hotelling extraction model is applied to sand mining in Ongjin, Korea and extended to include the estimated marginal external costs that mining imposes on marine fisheries. The socially efficient sand extraction plan is compared with the extraction paths suggested by scientific research. If marginal environmental costs are correctly estimated, the developed efficient extraction plan considering the resource rent may increase the social welfare and reduce the conflicts among the marine sand resource users. The empirical results are interpreted with an emphasis on guidelines for coastal resource management policy.

  7. SAGE II/Umkehr ozone comparisons and aerosols effects: An empirical and theoretical study. Final report

    SciTech Connect

    Newchurch, M.

    1997-09-15

    The objectives of this research were to: (1) examine empirically the aerosol effect on Umkehr ozone profiles using SAGE II aerosol and ozone data; (2) examine theoretically the aerosol effect on Umkehr ozone profiles; (3) examine the differences between SAGE II ozone profiles and both old- and new-format Umkehr ozone profiles for ozone-trend information; (4) reexamine SAGE I-Umkehr ozone differences with the most recent version of SAGE I data; and (5) contribute to the SAGE II science team.

  8. On Evaluating Language Proficiency Gain in Study Abroad Environments: An Empirical Study of American Students of Russian (A Preliminary Analysis of Data).

    ERIC Educational Resources Information Center

    Brecht, Richard D.; And Others

    A preliminary report on a long-term empirical investigation of advanced language acquisition in a study-abroad environment is presented. The project is based on an American Council of Teachers of Russian (ACTR) longitudinal study of the gains in Russian language competence demonstrated by American students in semester-long language programs in…

  9. [Depression and dementia: perspectives from clinical studies].

    PubMed

    Nozaki, Shoko; Yoshimura, Kimio; Mimura, Masaru

    2012-12-01

    In this review, we present an overview of clinical studies that addressed the relationship between depression and dementia or cognitive decline. Cross-sectional studies and meta-analyses have repeatedly shown an association between late-life depression (LLD) and dementia, particularly Alzheimer's disease (AD) and vascular dementia; however, the findings of cohort studies have been inconsistent. Furthermore, studies on the association between depression with a younger age of onset and dementia have yielded inconsistent results. Regarding cognitive decline associated with LLD, several studies have reported an association between LLD and mild cognitive impairment, suggesting that depression itself can cause persistent cognitive impairment. Other studies have compared the cognitive profile between LLD and depression with a younger age of onset, but their results have been inconclusive, especially regarding the association between memory impairment and the age of onset of depression. LLD is associated with vascular change and white matter degeneration of the brain, as shown by magnetic resonance imaging (MRI). Recently, several studies reported an association between gray matter change and LLD. Studies currently in progress employ functional brain imaging methods such as single-photon emission computed tomography, functional MRI, and positron emission tomography. Clinically, it is important to understand how subtypes of depression can be defined in terms of risk of developing dementia, and to devise effective treatments. One paper explored the possibility of detecting depression associated with AD by measuring the blood Aβ40/Aβ42 levels, and other studies have suggested that symptoms of apathy and loss of interest are associated with conversion of depression to AD. Unfortunately, current antidepressants may have limited efficacy on depression with dementia; therefore, further investigation for devising methods of predicting conversion of depression to dementia and

  10. Looking at the Schizophrenia Spectrum Through the Prism of Self-disorders: An Empirical Study

    PubMed Central

    Raballo, Andrea; Sæbye, Ditte; Parnas, Josef

    2011-01-01

    Nonpsychotic anomalies of subjective experience were emphasized in both classic literature and phenomenological psychiatry as essential clinical features of schizophrenia. However, only in recent years, their topicality with respect to the construct validity of the concept of the schizophrenia spectrum has been explicitly acknowledged, mainly as a consequence of the increasing focus on early detection and prevention of psychosis. The current study tested the hypothesis of a specific aggregation of self-disorders (SDs, various anomalies of self-awareness) in schizophrenia-spectrum conditions, comparing different diagnostic groups; 305 subjects, previously assessed in the Copenhagen Schizophrenia Linkage Study, were grouped into 4 experimental samples, according to their Diagnostic and Statistical Manual of Mental Disorders (Third Edition Revised) main diagnosis: schizophrenia, (n = 29), schizotypal personality disorder (n = 61), other mental illness not belonging to the schizophrenia spectrum (n = 112), and no mental illness (n = 103). The effect of diagnostic grouping on the level of SDs was explored via general linear model and logistic regression. The diagnosis of schizophrenia and schizotypy predicted higher levels of SDs, and SDs scores were significantly different between spectrum and nonspectrum samples; the likelihood of experiencing SDs increased as well with the diagnostic severity. The findings support the assumption that SDs are a discriminant psychopathological feature of the schizophrenia spectrum and suggest their incorporation to strengthen its construct validity, with potential benefit for both early detection and pathogenetic research. PMID:19528205

  11. Institutional ethics review of clinical study agreements.

    PubMed

    DuVal, G

    2004-02-01

    Clinical Study Agreements (CSAs) can have profound effects both on the protection of human subjects and on the independence of investigators to conduct research with scientific integrity. Sponsors, institutions, and even investigators may fail to give adequate attention to these issues in the negotiation of CSAs. Despite the key role of CSAs in structuring ethically important aspects of research, they remain largely unregulated and unreviewed for adherence to ethical norms. Academic institutions routinely enter into research contracts that fail to meet adequate ethical standards. This is a failing that can have serious consequences. Accordingly, it is necessary that some independent body have the authority both to review research contracts for compliance with norms of subject protection and ethical integrity, and to reject studies that fail to meet ethical standards. Such review should take place prior to the start of research, not later. Because of its expertise and authority, the institutional ethics review board (IRB or REB) is the appropriate body to undertake such review. Much recent commentary has focused on contractual restrictions on the investigator's freedom to publish research findings. The Olivieri experience, and that of other investigators, has brought freedom of publication issues into sharp focus. Clinical study agreements also raise a number of other ethical issues relating to human subjects and research integrity, however, including disclosures relating to patient safety, data analysis and reporting, budget, confidentiality, and premature termination of the study. This paper describes the ethical issues at stake in structuring such agreements and suggests ethical standards to guide institutional ethics review.

  12. Evidence-based review of clinical studies on pulpotomy.

    PubMed

    2009-08-01

    Although pulpotomy procedures have a long history of clinical application, comparatively few dental clinical trials have evaluated this treatment approach. In this section, we provide an analysis of recent clinical studies evaluating pulpotomy procedures in dental patients.

  13. A method to integrate descriptive and experimental field studies at the level of data and empirical concepts1

    PubMed Central

    Bijou, Sidney W.; Peterson, Robert F.; Ault, Marion H.

    1968-01-01

    It is the thesis of this paper that data from descriptive and experimental field studies can be interrelated at the level of data and empirical concepts if both sets are derived from frequency-of-occurrence measures. The methodology proposed for a descriptive field study is predicated on three assumptions: (1) The primary data of psychology are the observable interactions of a biological organism and environmental events, past and present. (2) Theoretical concepts and laws are derived from empirical concepts and laws, which in turn are derived from the raw data. (3) Descriptive field studies describe interactions between behavioral and environmental events; experimental field studies provide information on their functional relationships. The ingredients of a descriptive field investigation using frequency measures consist of: (1) specifying in objective terms the situation in which the study is conducted, (2) defining and recording behavioral and environmental events in observable terms, and (3) measuring observer reliability. Field descriptive studies following the procedures suggested here would reveal interesting new relationships in the usual ecological settings and would also provide provocative cues for experimental studies. On the other hand, field-experimental studies using frequency measures would probably yield findings that would suggest the need for describing new interactions in specific natural situations. PMID:16795175

  14. Sampling errors in the estimation of empirical orthogonal functions. [for climatology studies

    NASA Technical Reports Server (NTRS)

    North, G. R.; Bell, T. L.; Cahalan, R. F.; Moeng, F. J.

    1982-01-01

    Empirical Orthogonal Functions (EOF's), eigenvectors of the spatial cross-covariance matrix of a meteorological field, are reviewed with special attention given to the necessary weighting factors for gridded data and the sampling errors incurred when too small a sample is available. The geographical shape of an EOF shows large intersample variability when its associated eigenvalue is 'close' to a neighboring one. A rule of thumb indicating when an EOF is likely to be subject to large sampling fluctuations is presented. An explicit example, based on the statistics of the 500 mb geopotential height field, displays large intersample variability in the EOF's for sample sizes of a few hundred independent realizations, a size seldom exceeded by meteorological data sets.

  15. Visual evoked potentials in dementia: a meta-analysis and empirical study of Alzheimer's disease patients.

    PubMed

    Pollock, V E; Schneider, L S; Chui, H C; Henderson, V; Zemansky, M; Sloane, R B

    1989-04-15

    A meta-analytic review of flash and pattern reversal visual evoked potential research indicates that elderly demented patients have longer P100 latencies than age-matched control subjects. In the present empirical research, patients with research diagnoses of probable Alzheimer's disease were compared with sex- and age-matched control subjects using P100 latencies of visual evoked potentials (VEP) elicited by flash and pattern reversal. As compared to control subjects, Alzheimer's disease patients showed significantly longer P100 latencies of the VEP elicited by pattern reversal; the flash P100 only marginally distinguished them. These findings are discussed within the context of VEP recording practices, patient selection, sex and age matching of control subjects, and the visual system.

  16. Self-Organized Criticality and Stock Market Dynamics: an Empirical Study

    SciTech Connect

    M. Bartolozzi; D. B. Leinweber; A. W. Thomas

    2004-05-01

    The Stock Market is a complex self-interacting system, characterized by an intermittent behavior. Periods of high activity alternate with periods of relative calm. In the present work we investigate empirically about the possibility that the market is in a self-organized critical state (SOC). A wavelet transform method is used in order to separate high activity periods, related to the avalanches of sandpile models, from quiescent. A statistical analysis of the filtered data show a power law behavior in the avalanche size, duration and laminar times. The memory process, implied by the power law distribution, of the laminar times is not consistent with classical conservative models for self-organized criticality. We argue that a ''near-SOC'' state or a time dependence in the driver, which may be chaotic, can explain this behavior.

  17. An empirical study of the effect of the variables in a flash vacuum pyrolysis (FVP) experiment.

    PubMed

    Duffy, Emma F; Foot, Jonathan S; McNab, Hamish; Milligan, Andrew A

    2004-09-21

    The effect of the variation of the experimental parameters on the conversion of precursor to products in a typical flash vacuum pyrolysis (FVP) experiment was investigated empirically. Temperature-conversion plots can be used to optimise FVP conditions and their mechanistic significance is exemplified. At a given temperature, the conversion can be increased by an increase in the background pressure, or by packing a section of the furnace tube with inert material (particularly when placed at the trap end of the furnace tube) or by employing a catalyst. Despite the prevailing view that only intramolecular reactions take place by FVP, it has been shown by a 'dual-FVP' cross-over experiment that the dimerisation of benzyl radicals occurs in the gas-phase, before the cold trap, under standard conditions. However, reduction in through-put rate, increase in furnace temperature and reduction in background pressure all reduce the amount of gas-phase coupling.

  18. Angular cheilitis: a clinical and microbial study.

    PubMed

    Ohman, S C; Dahlén, G; Möller, A; Ohman, A

    1986-04-01

    The purpose of this prospective study was to re-examine the relative importance of various factors in the pathogenesis of angular cheilitis. Sixty-four patients with cheilitis were examined clinically and microbiologically. In addition, a subsample of 23 patients was examined for serum iron and transferrin. The clinical appearance of the lip lesions fell into 4 categories. A ground rhagad at the corner of the mouth involving adjacent skin, was the most frequent type among dentate patients, whereas among denture wearers a deep lesion following the labial marginal sulcus was frequently observed. Dentate patients and denture wearers with cheilitis often had atopic constitution or cutaneous diseases. Pathogenic microorganisms were cultured from the lesions in all 64 patients; Staphylococcus aureus in 40 patients and Candida albicans in 45. The results of this study indicate a correlation between angular cheilitis and pathogenic microorganisms. Furthermore, among dentate patients, a correlation exists between cutaneous discomfort and angular cheilitis. Other etiological factors suggested for this disorder were found to be of subordinate importance.

  19. Perspectives of clinical genetics professionals toward genome sequencing and incidental findings: A survey study

    PubMed Central

    Lemke, AA; Bick, D; Dimmock, D; Simpson, P; Veith, R

    2013-01-01

    The introduction of clinical genome-wide sequencing raises complex issues regarding the management of incidental findings. However, there is a lack of empirical studies assessing views of providers involved in potential disclosure of such findings. In an anonymous survey of 279 clinical genetics professionals, we found that the vast majority agreed they were interested in knowing about clinically actionable incidental findings in themselves (96%) and their child (99%), and they reported that these types of findings should be disclosed in adult (96%) and minor (98%) patients. Approximately three-fourths agreed they were personally interested in knowing about an adult-onset clinically actionable disease (78%), and a childhood-onset non-clinically actionable disease (75%) in their child. A similar percentage of participants (70%) felt these two types of findings should be disclosed to patients. Forty-four percent wanted to know about an incidental finding that indicates an adult-onset non-clinically actionable condition in themselves and 31% wanted to know about this type of information in their child. Findings from this study revealed participant views highly dependent on clinical actionability. Further research is needed with a broader population of geneticists to increase generalizability, and with diverse patients to assess their perspectives about results disclosure from clinical sequencing. PMID:23163796

  20. Innovation in Information Technology: Theoretical and Empirical Study in SMQR Section of Export Import in Automotive Industry

    NASA Astrophysics Data System (ADS)

    Edi Nugroho Soebandrija, Khristian; Pratama, Yogi

    2014-03-01

    This paper has the objective to provide the innovation in information technology in both theoretical and empirical study. Precisely, both aspects relate to the Shortage Mispacking Quality Report (SMQR) Claims in Export and Import in Automotive Industry. This paper discusses the major aspects of Innovation, Information Technology, Performance and Competitive Advantage. Furthermore, In the empirical study of PT. Astra Honda Motor (AHM) refers to SMQR Claims, Communication Systems, Analysis and Design Systems. Briefly both aspects of the major aspects and its empirical study are discussed in the Introduction Session. Furthermore, the more detail discussion is conducted in the related aspects in other sessions of this paper, in particular in Literature Review in term classical and updated reference of current research. The increases of SMQR claim and communication problem at PT. Astra Daihatsu Motor (PT. ADM) which still using the email cause the time of claim settlement become longer and finally it causes the rejected of SMQR claim by supplier. With presence of this problem then performed to design the integrated communication system to manage the communication process of SMQR claim between PT. ADM with supplier. The systems was analyzed and designed is expected to facilitate the claim communication process so that can be run in accordance with the procedure and fulfill the target of claim settlement time and also eliminate the difficulties and problems on the previous manual communication system with the email. The design process of the system using the approach of system development life cycle method by Kendall & Kendall (2006)which design process covers the SMQR problem communication process, judgment process by the supplier, claim process, claim payment process and claim monitoring process. After getting the appropriate system designs for managing the SMQR claim, furthermore performed the system implementation and can be seen the improvement in claim communication

  1. Controlled outcome studies of child clinical hypnosis.

    PubMed

    Adinolfi, Barbara; Gava, Nicoletta

    2013-09-01

    Background Hypnosis is defined as "as an interaction in which the hypnotist uses suggested scenarios ("suggestions") to encourage a person's focus of attention to shift towards inner experiences". Aim of the work The focus of this review is to summarize the findings of controlled outcome studies investigating the potential of clinical hypnosis in pediatric populations. We will examine the following themes: anesthesia, acute and chronic pain, chemotherapy-related distress, along with other specific medical issues. Results Hypnosis is an effective method to reduce pain and anxiety before, during and after the administration of anesthetics, during local dental treatments, invasive medical procedures and in burn children. Hypnosis can be successfully used to manage recurrent headaches, abdominal pain, irritable bowel syndrome and chemotherapy-related distress. Hypnosis has an important role in managing symptoms and improving the quality of life of children suffering from asthma and cystic fibrosis and in facilitating the treatment of insomnia in school-age children. Finally, hypnosis can be effectively used for the treatment of some habitual disorders such as nocturnal enuresis and dermatologic conditions, including atopic dermatitis and chronic eczema Conclusions Clinical hypnosis seems to be a useful, cheap and side-effects free tool to manage fear, pain and several kinds of stressful experiences in pediatric populations. Children who receive self-hypnosis trainings achieve significantly greater improvements in their physical health, quality of life, and self-esteem.

  2. [Purine metabolism in ankylosing spondylitis: clinical study].

    PubMed

    Jiménez Balderas, F J; Robles, E J; Juan, L; Badui, E; Arellano, H; Espinosa Said, L; Mintz Spiro, G

    1989-01-01

    We undertook a prospective study of 23 male patients with Ankylosing Spondylitis (AS) (New York Criteria), 18 HLA-B27 positive and 5 HLA-B27 negative, five of them had hyperuricemia. The following data of evolution were taken into consideration: age at onset of disease, time course of the disease, presence of urolithiasis, heart disease, flares of uveitis. Clinical activity and degree of disability were evaluated every one to 3 months; on each visit, every patient had determinations of serum and urinary uric acid levels, serum and phosphorus, erythrocyte sedimentation rate (ESR), serum protein electrophoresis, as well as X-ray films of the vertebral spine and pelvis. Three groups of patients were detected, all of them with equal age at onset, duration of disease, frequency of B27, peripheral arthritis, and leukocytosis. One group had hyperuricemia (5 of 23 patients, 80% of them HLA-B27 positive) and a lesser degree of clinical activity of the disease (p less than .001, a higher frequency of uveitis (40%, lower levels of serum gammaglobulins (p less than 0.05) and ESR (p less than 0.05), a lesser degree of ankylosis of the spine, and a better functional prognosis than the other groups. Another group (8 of 23 patients, 75% of them were HLA-B27 positive) had normouricemia and hyperuricosuria, and showed a higher frequency of fever (50%), an abnormal urinalysis, and urolithiasis (25%).

  3. Clinical studies of intestinal folate conjugases.

    PubMed

    Halsted, C H; Beer, W H; Chandler, C J; Ross, K; Wolfe, B M; Bailey, L; Cerda, J J

    1986-03-01

    Clinical differences between the two human intestinal mucosal folate conjugases were assessed by measurement of their activities in normal individuals and in patients with chronic diarrhea of differing causes. Intracellular folate conjugase (ICFC) was 15-fold more active than brush border folate conjugase (BBFC) in jejunal mucosa from seven obese patients undergoing elective gastric bypass surgery. The activity of ICFC was similar among normal volunteers and patients with diarrhea of unknown origin (DUO), gluten-sensitive enteropathy (GSE), inflammatory bowel disease (IBD), and the short bowel syndrome (IBD-SBS). By contrast, BBFC, sucrase, and lactase were decreased significantly in GSE, and BBFC was increased in IBD-SBS. The activity of BBFC correlated with lactase and with sucrase in the normal subjects and in patients with DUO, whereas no correlations were found with the activity of ICFC in any group. Our clinical studies confirm that ICFC and BBFC are different enzymes. ICFC is not affected by intestinal disease, whereas the activity of jejunal BBFC, like that of other brush border enzymes, is decreased by mucosal injury and is also capable of adapting to distal small intestinal disease or surgical resection.

  4. Development of empirical potential functions for the study of molecular geometry, and applications to chlorophyll a dimers

    SciTech Connect

    Oie, Tetsuro

    1980-07-28

    A purpose of the present studies is twofold: (1) development of an empirical potential function (EDF) and (2) application of it to the studies of photoreaction center chlorophyll a dimer. The reliable estimate of geometric structures and energies of large molecules by quantum mechanical methods is not possible at the present time. An alternative method is, therefore, needed for the studies of large molecular systems, and Chapter I is dedicated to the development of this tool, i.e., an empirical potential function, which could suffice this purpose. Because of a large number of variable chemical compositions and functional groups characteristically present in a large molecule, it is important to include a large number of structurally diverse molecules in the development of the EPF. In Chapter II, the EPF is applied to study the geometrical structure of a chlorophyll a (Ch1 a) dimer, which is believed to exist at the photoreaction center of green plants and is known to play an essential role in photosynthetic energy conversion. Although various models have been proposed for this dimer structure, there is still a great need for information concerning the detailed geometric structure of this dimer. Therefore, in this chapter the structural stabilities of various dimer models are examined by the EPF, and detailed and quantitative information on the structure and stability of these models is provided.

  5. Development of empirical potential functions for the study of molecular geometry, and applications to chlorophyll a dimers. [Dissertation

    SciTech Connect

    Oie, Tetsuro

    1980-01-01

    A purpose of the present studies is twofold: (1) development of an empirical potential function (EPF) and (2) application of it to the studies of photoreaction center chlorophyll a dimer. The reliable estimate of geometric structures and energies of large molecules by quantum mechanical methods is not possible at the present time. An alternative method is, therefore, needed for the studies of large molecular systems, and Chapter I is dedicated to the development of this tool, i.e., an empirical potential function, which could suffice this purpose. Because of a large number of variable chemical compositions and functional groups characteristically present in a large molecule, it is important to include a large number of structurally diverse molecules in the development of the EPF. In Chapter II, the EPF is applied to study the geometrical structure of a chlorophyll a (Chl a) dimer, which is believed to exist at the photoreaction center of green plants and is known to play an essential role in photosynthetic energy conversion. Although various models have been proposed for this dimer structure, there is still a great need for information concerning the detailed geometric structure of this dimer. Therefore, in this chapter the structural stabilities of various dimer models are examined by the EPF, and detailed and quantitative information on the structure and stability of these models is provided.

  6. Epidemiological and Clinical Studies of Nutrition

    PubMed Central

    Gibson, Todd M.; Ferrucci, Leah M.; Tangrea, Joseph A.; Schatzkin, Arthur

    2010-01-01

    In this review, we briefly summarize some of the key developments in nutritional epidemiology and cancer over the past two decades with a focus on the strengths and limitations of study designs and dietary assessment methods. We present the evidence on dietary fat, meat, fiber, antioxidant nutrients, and calcium in relation to carcinogenesis from large cohort studies and randomized clinical trials (RCTs) and refer to the conclusions of the 2007 World Cancer Research Fund/American Institute for Cancer Research summary report. One prominent theme that emerged is the lack of concordance of results from RCTs and observational studies. There are multiple potential reasons for these discrepancies, including differences in study population, dose and timing of the exposure, adherence to an intervention, length of follow-up, and the primary endpoint. Therefore, null findings of RCTs do not necessarily indicate a lack of effect for the tested dietary factors on cancer risk, as some of these nutrients may have chemopreventive effects if given at the right time and in the right dose. It is likely that potential benefits from the diet are due to a combination of food constituents rather than single components acting in isolation. Future efforts need to recognize the integrative nature of dietary exposures and attempt to study nutrients in the larger context of the foods and diets in which they are consumed. PMID:20709210

  7. [Clinical study on mandibular bone fractures].

    PubMed

    Bahk, J S

    1989-05-01

    The purpose of this study was to investigate and to classify the patients of mandibular bone fracture who were hospitalized in the Kang-nam General Hospital. We observed clinically 57 patients from July 1983 to August 1988. The results obtained were as follows: 1. The ratio of male to female was about 6.1:1. 2. The highest age incidence was 3rd decade age group. 3. The most frequent etiologic factor was falling-down (36.8%). The next factors were fist-blow (31.6%), traffic accident (15.8%), sports (5.3%) and works (5.3%) in order. 4. The most frequent site of mandibular fractures was symphyseal area (23.1%), and mandibular angle (20.5%), condyle (19.2%), body (19.2%), alveolar bone (9.0%) and ramus (7.7%) were next in order.

  8. Managing Complex Change in Clinical Study Metadata

    PubMed Central

    Brandt, Cynthia A.; Gadagkar, Rohit; Rodriguez, Cesar; Nadkarni, Prakash M.

    2004-01-01

    In highly functional metadata-driven software, the interrelationships within the metadata become complex, and maintenance becomes challenging. We describe an approach to metadata management that uses a knowledge-base subschema to store centralized information about metadata dependencies and use cases involving specific types of metadata modification. Our system borrows ideas from production-rule systems in that some of this information is a high-level specification that is interpreted and executed dynamically by a middleware engine. Our approach is implemented in TrialDB, a generic clinical study data management system. We review approaches that have been used for metadata management in other contexts and describe the features, capabilities, and limitations of our system. PMID:15187070

  9. Oncolysis by paramyxoviruses: preclinical and clinical studies

    PubMed Central

    Matveeva, Olga V; Guo, Zong S; Senin, Vyacheslav M; Senina, Anna V; Shabalina, Svetlana A; Chumakov, Peter M

    2015-01-01

    Preclinical studies demonstrate that a broad spectrum of human malignant cells can be killed by oncolytic paramyxoviruses, which include cells of ecto-, endo-, and mesodermal origin. In clinical trials, significant reduction in size or even complete elimination of primary tumors and established metastases are reported. Different routes of viral administration (intratumoral, intravenous, intradermal, intraperitoneal, or intrapleural), and single- versus multiple-dose administration schemes have been explored. The reported side effects are grade 1 and 2, with the most common among them being mild fever. Some advantages in using paramyxoviruses as oncolytic agents versus representatives of other viral families exist. The cytoplasmic replication results in a lack of host genome integration and recombination, which makes paramyxoviruses safer and more attractive candidates for widely used therapeutic oncolysis in comparison with retroviruses or some DNA viruses. The list of oncolytic paramyxovirus representatives includes attenuated measles virus (MV), mumps virus (MuV), low pathogenic Newcastle disease (NDV), and Sendai (SeV) viruses. Metastatic cancer cells frequently overexpress on their surface some molecules that can serve as receptors for MV, MuV, NDV, and SeV. This promotes specific viral attachment to the malignant cell, which is frequently followed by specific viral replication. The paramyxoviruses are capable of inducing efficient syncytium-mediated lyses of cancer cells and elicit strong immunomodulatory effects that dramatically enforce anticancer immune surveillance. In general, preclinical studies and phase 1–3 clinical trials yield very encouraging results and warrant continued research of oncolytic paramyxoviruses as a particularly valuable addition to the existing panel of cancer-fighting approaches. PMID:26640815

  10. Exorcising Grice's ghost: an empirical approach to studying intentional communication in animals.

    PubMed

    Townsend, Simon W; Koski, Sonja E; Byrne, Richard W; Slocombe, Katie E; Bickel, Balthasar; Boeckle, Markus; Braga Goncalves, Ines; Burkart, Judith M; Flower, Tom; Gaunet, Florence; Glock, Hans Johann; Gruber, Thibaud; Jansen, David A W A M; Liebal, Katja; Linke, Angelika; Miklósi, Ádám; Moore, Richard; van Schaik, Carel P; Stoll, Sabine; Vail, Alex; Waller, Bridget M; Wild, Markus; Zuberbühler, Klaus; Manser, Marta B

    2016-08-02

    Language's intentional nature has been highlighted as a crucial feature distinguishing it from other communication systems. Specifically, language is often thought to depend on highly structured intentional action and mutual mindreading by a communicator and recipient. Whilst similar abilities in animals can shed light on the evolution of intentionality, they remain challenging to detect unambiguously. We revisit animal intentional communication and suggest that progress in identifying analogous capacities has been complicated by (i) the assumption that intentional (that is, voluntary) production of communicative acts requires mental-state attribution, and (ii) variation in approaches investigating communication across sensory modalities. To move forward, we argue that a framework fusing research across modalities and species is required. We structure intentional communication into a series of requirements, each of which can be operationalised, investigated empirically, and must be met for purposive, intentionally communicative acts to be demonstrated. Our unified approach helps elucidate the distribution of animal intentional communication and subsequently serves to clarify what is meant by attributions of intentional communication in animals and humans.

  11. Strategies and Challenges for Energy Efficient Retrofitting: Study of the Empire State Building

    NASA Astrophysics Data System (ADS)

    De, B.; Mukherjee, M.

    2013-11-01

    Operational and maintenance cost of existing buildings is escalating making it tough for both the owner and the tenants. Retrofitting them with state of the art technologies help them to keep pace with amended recent code provisions and thus extending the older building stocks one more chance to live responsively. Retrofitted iconic buildings can thus retain their status in commerce driven real estate sector. It helps in reducing green house gas emission as well. World's iconic skyscraper, the Empire State Building (ESB), has undergone an exemplary retrofit process since 2008 to reduce its energy demands. To achieve the goal of operational cost and energy consumption reduction, stiff challenges had taken care in a systematic manner to realize benefit throughout the entire lifespan of the ESB. Least disturbances to the tenant and on-site component handling strategies required precise planning. The present paper explores strategies and process adopted for retrofitting the ESB, and derived insightful guidelines towards operational cost savings and energy efficiency of existing buildings through retrofitting.

  12. Directionality theory: an empirical study of an entropic principle in life-history evolution.

    PubMed

    Ziehe, Martin; Demetrius, Lloyd

    2005-06-07

    Understanding the relationship between ecological constraints and life-history properties constitutes a central problem in evolutionary ecology. Directionality theory, a model of the evolutionary process based on demographic entropy, a measure of the uncertainty in the age of the mother of a randomly chosen newborn, provides an analytical framework for addressing this problem. The theory predicts that in populations that spend the greater part of their evolutionary history in the stationary growth phase (equilibrium species), entropy will increase. Equilibrium species will be characterized by high iteroparity and strong demographic stability. In populations that spend the greater part of their evolutionary history in the exponential growth phase (opportunistic species), entropy will decrease when population size is large, and will undergo random variation when population size is small. Opportunistic species will be characterized by weak iteroparity and weak demographic stability when population size is large, and random variations in these attributes when population size is small. This paper assesses the validity of these predictions by employing a demographic dataset of 66 species of perennial plants. This empirical analysis is consistent with directionality theory and provides support for its significance as an explanatory and predictive model of life-history evolution.

  13. [Empirical study of the market orientation of veterinarians in The Netherlands].

    PubMed

    Schuurmans, A J; Smidts, A

    1990-04-01

    Linked to the theoretical framework of marketing in the veterinary practice, as explained in Schuurmans and Smidts (1) pp. 1-10 and Schuurmans and Smidts (2), an empirical research project has been undertaken. This research gives insight into the extent to which practices base their services on a marketing orientation. By means of telephone inquiries among a sample of 166 veterinarians, this was investigated. The research shows that veterinarians think more in a product-oriented way than in a market-oriented way, and they do not use all the opportunities a marketing orientation could bring to their services. This expresses itself, among others by not using market segmentation, by the inadequate use of the marketing mix elements communication and distribution, and by the fact that the opportunities of the marketing information system are hardly applied. By means of further research in individual practices it might be possible to give concrete advise fit for that practice. Research among the clients of the veterinarians might, beside many other kinds of research, also give valuable insights.

  14. Reducing Adverse Polypharmacy in Patients With Borderline Personality Disorder: An Empirical Case Study

    PubMed Central

    Oldham, John M.; Gonzalez, Sylvia; Fowler, J. Christopher

    2015-01-01

    Objective: Polypharmacy is common and especially challenging in the context of borderline personality disorder in light of impulsivity and self-harm associated with the disorder, risk of adverse drug-drug interactions, and financial burden. Reduction in polypharmacy could be conceptualized as a high priority in the treatment of borderline personality disorder. This case aims to demonstrate that potential. Method: This case report presents outcomes data for an individual with borderline personality disorder during the course of an extended psychiatric hospitalization. Symptomatic change is based on the Patient Health Questionnaire Somatic, Anxiety, and Depression Symptoms scales and World Health Organization 5-Item Well-Being Index. Change in polypharmacy is presented both in terms of absolute number and complexity of the medication regimen. Clinical outcomes data are provided at 2, 12, and 24 weeks postdischarge. Results: During a 56-day hospitalization, the patient demonstrated clinical improvement across clinical domains—all occurred within the context of reduced number (43%) and complexity (40%) of her medication regimen. Symptomatic improvement was sustained up to 6 months postdischarge. Conclusions: Despite good intentions, polypharmacy can be associated with iatrogenic harm and contribute to functional impairment, especially in the context of borderline personality disorder, in which symptomatic fluctuations are part of the illness itself. A reduction in the patient’s high-risk polypharmacy during treatment represents a noteworthy treatment outcome in and of itself. Additional measures of medication risk and liability have the potential to become markers of clinical effectiveness. PMID:26693036

  15. An Empirical Study of why our Cognition Toward Environmental Sustainability is Inconsistent with our Behavior: Policy Implications

    NASA Astrophysics Data System (ADS)

    Ho, S. Ping

    2016-04-01

    Raising public awareness of human environmental problems has been considered an effective way to promote public participation in environmental sustainability. From the perspective individual level, such participation mainly include the willingness of adopting less consumptive lifestyles and following the principles of reuse, reduce, and recycle. However, in reality, the development of environmental sustainability falls into the "Enlightenment Fallacy," which asserts that enlightenment does not consequentially translate into meaningful reduction of pollution. We argue that environmental awareness is mainly at the level of cognition, which is built upon knowledge and facts; whereas the behaviors toward sustainability development are largely dominated by economic principles that focus on utility maximization. As such, the Enlightenment Fallacy can be explained by the "Tragedy of Commons" which occurrs in the prevailing capitalism based economic system. This is due to the sad fact assumed in modern Economics that human beings are in general self-interested with unending desires but few moral concerns. Thus, economic individuals, who seek mainly their maximal utility or benefit, will not make significant sacrifices for improving environmental sustainability, which cannot be achieved by only a few individuals. From this perspective, we argue that only those individuals who are less self-interested and have more compassion toward mankind and earth will actively participate in environmental sustainability. In this study, we examine empirically the Enlightenment Fallacy phenomenon and develop an empirical model to test the following four hypotheses concerning the inconsistency between the environmental cognition and the actual behaviors. Policy implications for promoting public participation will be suggested based on our empirical results. Hypothesis 1: Compassion (for mankind) has larger positive impacts than environmental cognition. Hypothesis 2: Social punishment and

  16. An Empirical Study of Neural Network-Based Audience Response Technology in a Human Anatomy Course for Pharmacy Students.

    PubMed

    Fernández-Alemán, José Luis; López-González, Laura; González-Sequeros, Ofelia; Jayne, Chrisina; López-Jiménez, Juan José; Carrillo-de-Gea, Juan Manuel; Toval, Ambrosio

    2016-04-01

    This paper presents an empirical study of a formative neural network-based assessment approach by using mobile technology to provide pharmacy students with intelligent diagnostic feedback. An unsupervised learning algorithm was integrated with an audience response system called SIDRA in order to generate states that collect some commonality in responses to questions and add diagnostic feedback for guided learning. A total of 89 pharmacy students enrolled on a Human Anatomy course were taught using two different teaching methods. Forty-four students employed intelligent SIDRA (i-SIDRA), whereas 45 students received the same training but without using i-SIDRA. A statistically significant difference was found between the experimental group (i-SIDRA) and the control group (traditional learning methodology), with T (87) = 6.598, p < 0.001. In four MCQs tests, the difference between the number of correct answers in the first attempt and in the last attempt was also studied. A global effect size of 0.644 was achieved in the meta-analysis carried out. The students expressed satisfaction with the content provided by i-SIDRA and the methodology used during the process of learning anatomy (M = 4.59). The new empirical contribution presented in this paper allows instructors to perform post hoc analyses of each particular student's progress to ensure appropriate training.

  17. Empirical study of Kanji as archetypal images: understanding the collective unconscious as part of the Japanese language.

    PubMed

    Sotirova-Kohli, Milena; Rosen, David H; Smith, Steven M; Henderson, Patti; Taki-Reece, Sachiko

    2011-02-01

    Chinese characters originated as a semiotic system independent from spoken language and in the Japanese language they function non-phonetically with speakers exhibiting right-hemispheric advantage in their processing. We tested the hypothesis that Chinese characters are archetypal images and therefore part of our collective unconscious memory. Our study builds on the first empirical study of archetypal memory of Rosen et al. (1991) which demonstrated that archetypal symbols presented matched with their correct meaning were better learned and recalled. In a series of three experiments we used 40 Chinese characters instead of the archetypal symbols used by Rosen, et al. (1991). The results provided empirical evidence that Chinese characters matched with their correct meaning were significantly better recalled than the ones that were mismatched. Thus, we demonstrated that there appears to be unconscious knowledge of the meaning of the Chinese characters which was triggered as a result of priming when the characters were correctly matched with their meaning. On this basis, we suggest that Chinese characters exhibit the same cognitive qualities as archetypal symbols. Thus, in the Japanese language an archetypal image is integrated non-phonetically into the system of language and signifies the concept independent from the phonetic signifier and is equal to it.

  18. Erythroderma: A clinical study of 97 cases

    PubMed Central

    Akhyani, Maryam; Ghodsi, Zahra S; Toosi, Siavash; Dabbaghian, Hossein

    2005-01-01

    Background Erythroderma is a rare skin disorder that may be caused by a variety of underlying dermatoses, infections, systemic diseases and drugs. Methods We reviewed the clinical, laboratory and biopsy material of 97 patients diagnosed with erythroderma who were treated in our department over a 6-year period (1996 through 2002). Results The male-female ratio was 1.85:1. The mean age at diagnosis was 46.2 years. The most common causative factors were dermatoses (59.7%), followed by drug reactions (21.6%), malignancies (11.3%) and idiopathic causes (7.2%). Carbamazepine was the most common drug (57.1%). The best clinicopathologic correlation was found in cutaneous T-cell lymphoma and pityriasis rubra pilaris related erythroderma. Apart from scaling and erythema that were present in all patients, pruritus was the most common finding (97.5%), followed by fever (33.6%), lymphadenopathy (21.3%), edema (14.4%) and hyperkeratosis (7.2%). Conclusion This study outlines that underlying etiologic factors of erythroderma may show geographic variations. Our series had a high percentage of erythroderma secondary to preexisting dermatoses and a low percentage of idiopathic cases. There was no HIV-infected patient among our series based on multiple serum antibody tests. The clinical features of erythroderma were identical, irrespective of the etiology. The onset of the disease was usually insidious except in drug-induced erythroderma, where it was acute. The group associated with the best prognosis was that related to drugs. PMID:15882451

  19. Statistical Issues in TBI Clinical Studies

    PubMed Central

    Rapp, Paul E.; Cellucci, Christopher J.; Keyser, David O.; Gilpin, Adele M. K.; Darmon, David M.

    2013-01-01

    The identification and longitudinal assessment of traumatic brain injury presents several challenges. Because these injuries can have subtle effects, efforts to find quantitative physiological measures that can be used to characterize traumatic brain injury are receiving increased attention. The results of this research must be considered with care. Six reasons for cautious assessment are outlined in this paper. None of the issues raised here are new. They are standard elements in the technical literature that describes the mathematical analysis of clinical data. The purpose of this paper is to draw attention to these issues because they need to be considered when clinicians evaluate the usefulness of this research. In some instances these points are demonstrated by simulation studies of diagnostic processes. We take as an additional objective the explicit presentation of the mathematical methods used to reach these conclusions. This material is in the appendices. The following points are made: (1) A statistically significant separation of a clinical population from a control population does not ensure a successful diagnostic procedure. (2) Adding more variables to a diagnostic discrimination can, in some instances, actually reduce classification accuracy. (3) A high sensitivity and specificity in a TBI versus control population classification does not ensure diagnostic successes when the method is applied in a more general neuropsychiatric population. (4) Evaluation of treatment effectiveness must recognize that high variability is a pronounced characteristic of an injured central nervous system and that results can be confounded by either disease progression or spontaneous recovery. A large pre-treatment versus post-treatment effect size does not, of itself, establish a successful treatment. (5) A procedure for discriminating between treatment responders and non-responders requires, minimally, a two phase investigation. This procedure must include a mechanism to

  20. Comparing the Effectiveness of a Clinical Registry and a Clinical Data Warehouse for Supporting Clinical Trial Recruitment: A Case Study

    PubMed Central

    Weng, Chunhua; Bigger, J Thomas; Busacca, Linda; Wilcox, Adam; Getaneh, Asqual

    2010-01-01

    This paper reports a case study comparing the relative efficiency of using a Diabetes Registry or a Clinical Data Warehouse to recruit participants for a diabetes clinical trial, TECOS. The Clinical Data Warehouse generated higher positive predictive accuracy (31% vs. 6.6%) and higher participant recruitment than the Registry (30 vs. 14 participants) in a shorter time period (59 vs. 74 working days). We identify important factors that increase clinical trial recruitment efficiency and lower cost. PMID:21347102

  1. Comparing the effectiveness of a clinical registry and a clinical data warehouse for supporting clinical trial recruitment: a case study.

    PubMed

    Weng, Chunhua; Bigger, J Thomas; Busacca, Linda; Wilcox, Adam; Getaneh, Asqual

    2010-11-13

    This paper reports a case study comparing the relative efficiency of using a Diabetes Registry or a Clinical Data Warehouse to recruit participants for a diabetes clinical trial, TECOS. The Clinical Data Warehouse generated higher positive predictive accuracy (31% vs. 6.6%) and higher participant recruitment than the Registry (30 vs. 14 participants) in a shorter time period (59 vs. 74 working days). We identify important factors that increase clinical trial recruitment efficiency and lower cost.

  2. An empirical study of the wound effect on sap flux density measured with thermal dissipation probes.

    PubMed

    Wiedemann, Andreas; Marañón-Jiménez, Sara; Rebmann, Corinna; Herbst, Mathias; Cuntz, Matthias

    2016-12-01

    The insertion of thermal dissipation (TD) sensors on tree stems for sap flux density (SFD) measurements can lead to SFD underestimations due to a wound formation close to the drill hole. However, the wound effect has not been assessed experimentally for this method yet. Here, we propose an empirical approach to investigate the effect of the wound healing on measured sap flux with TD probes. The approach was performed for both, diffuse-porous (Fagus sylvatica (Linnaeus)) and ring-porous (Quercus petraea (Lieblein)) species. Thermal dissipation probes were installed on different dates along the growing season to document the effects of the dynamic wound formation. The trees were cut in autumn and additional sensors were installed in the cut stems, therefore, without potential effects of wound development. A range of water pressures was applied to the stem segments and SFDs were simultaneously measured by TD sensors as well as gravimetrically in the laboratory. The formation of wounds around sensors installed in living tree stems led to underestimation of SFD by 21.4 ± 3 and 47.5 ± 3.8% in beech and oak, respectively. The differences between SFD underestimations of diffuse-porous beech and ring-porous oak were, however, not statistically significant. Sensors with 5-, 11- and 22-week-old wounds also showed no significant differences, which implies that the influence of wound formation on SFD estimates was completed within the first few weeks after perforation. These results were confirmed by time courses of SFD measurements in the field. Field SFD values decreased immediately after sensor installation and reached stable values after ~2 weeks with similar underestimations to the ones observed in the laboratory. We therefore propose a feasible approach to correct directly field observations of SFD for potential underestimations due to the wound effect.

  3. Empirical studies on informal patient payments for health care services: a systematic and critical review of research methods and instruments

    PubMed Central

    2010-01-01

    Background Empirical evidence demonstrates that informal patient payments are an important feature of many health care systems. However, the study of these payments is a challenging task because of their potentially illegal and sensitive nature. The aim of this paper is to provide a systematic review and analysis of key methodological difficulties in measuring informal patient payments. Methods The systematic review was based on the following eligibility criteria: English language publications that reported on empirical studies measuring informal patient payments. There were no limitations with regard to the year of publication. The content of the publications was analysed qualitatively and the results were organised in the form of tables. Data sources were Econlit, Econpapers, Medline, PubMed, ScienceDirect, SocINDEX. Results Informal payments for health care services are most often investigated in studies involving patients or the general public, but providers and officials are also sample units in some studies. The majority of the studies apply a single mode of data collection that involves either face-to-face interviews or group discussions. One of the main methodological difficulties reported in the publication concerns the inability of some respondents to distinguish between official and unofficial payments. Another complication is associated with the refusal of some respondents to answer questions on informal patient payments. We do not exclude the possibility that we have missed studies that reported in non-English language journals as well as very recent studies that are not yet published. Conclusions Given the recent evidence from research on survey methods, a self-administrated questionnaire during a face-to-face interview could be a suitable mode of collecting sensitive data, such as data on informal patient payments. PMID:20849658

  4. Risk factors for victimization in romantic relationships of young women: a review of empirical studies and implications for prevention.

    PubMed

    Vézina, Johanne; Hébert, Martine

    2007-01-01

    This article reviews the literature on risk factors for victimization in romantic relationships of adolescent girls and young adult women. The review includes 61 empirical studies published between 1986 and 2006 that have investigated risk factors for sustained psychological, sexual, and physical violence in romantic relationships of young women ages 12 to 24. An ecological approach is used as a conceptual model to review risk factors into four categories: sociodemographic factors, individual factors (personal and interpersonal), environmental factors (family, community, and peers), and contextual factors (linked to the romantic relationship). Methodological limitations of the studies in terms of measurement issues, samples studied, research designs, and underlying conceptual models are discussed. Finally, implications for prevention programming are considered. Recommendations are presented about which clientele should be targeted, which risk factors should be considered, and when programs should be implemented.

  5. An empirical study of statistical properties of variance partition coefficients for multi-level logistic regression models

    USGS Publications Warehouse

    Li, J.; Gray, B.R.; Bates, D.M.

    2008-01-01

    Partitioning the variance of a response by design levels is challenging for binomial and other discrete outcomes. Goldstein (2003) proposed four definitions for variance partitioning coefficients (VPC) under a two-level logistic regression model. In this study, we explicitly derived formulae for multi-level logistic regression model and subsequently studied the distributional properties of the calculated VPCs. Using simulations and a vegetation dataset, we demonstrated associations between different VPC definitions, the importance of methods for estimating VPCs (by comparing VPC obtained using Laplace and penalized quasilikehood methods), and bivariate dependence between VPCs calculated at different levels. Such an empirical study lends an immediate support to wider applications of VPC in scientific data analysis.

  6. Empire: An Analytical Category for Educational Research

    ERIC Educational Resources Information Center

    Coloma, Roland Sintos

    2013-01-01

    In this article Roland Sintos Coloma argues for the relevance of empire as an analytical category in educational research. He points out the silence in mainstream studies of education on the subject of empire, the various interpretive approaches to deploying empire as an analytic, and the importance of indigeneity in research on empire and…

  7. Empirical tests of the Chicago model and the Easterlin hypothesis: a case study of Japan.

    PubMed

    Ohbuchi, H

    1982-05-01

    The objective of this discussion is to test the applicability of economic theory of fertility with special reference to postwar Japan and to find a clue for forecasting the future trend of fertility. The theories examined are the "Chicago model" and the "Easterlin hypothesis." The major conclusion common among the leading economic theories of fertility, which have their origin with Gary S. Becker (1960, 1965) and Richard A. Easterlin (1966), is the positive income effect, i.e., that the relationship between income and fertility is positive despite the evidence that higher income families have fewer children and that fertility has declined with economic development. To bridge the gap between theory and fact is the primary purpose of the economic theory of fertility, and each offers a different interpretation for it. The point of the Chicago model, particularly of the household decision making model of the "new home economics," is the mechanism that a positive effect of husband's income growth on fertility is offset by a negative price effect caused by the opportunity cost of wife's time. While the opportunity cost of wife's time is independent of the female wage rate for an unemployed wife, it is directly associated with the wage rate for a gainfully employed wife. Thus, the fertility response to female wages occurs only among families with an employed wife. The primary concern of empirical efforts to test the Chicago model has been with the determination of income and price elasticities. An attempt is made to test the relevance of the Chicago model and the Easterlin hypothesis in explaning the fertility movement in postwar Japan. In case of the Chicago model, the statistical results appeared fairly successful but did not match with the theory. The effect on fertility of a rise in women's real wage (and, therefore in the opportunity cost of mother's time) and of a rise in labor force participation rate of married women of childbearing age in recent years could not

  8. Hormones, nicotine, and cocaine: clinical studies.

    PubMed

    Mello, Nancy K

    2010-06-01

    Nicotine and cocaine each stimulate hypothalamic-pituitary-adrenal and -gonadal axis hormones, and there is increasing evidence that the hormonal milieu may modulate the abuse-related effects of these drugs. This review summarizes some clinical studies of the acute effects of cigarette smoking or IV cocaine on plasma drug and hormone levels and subjective effects ratings. The temporal covariance between these dependent measures was assessed with a rapid (2 min) sampling procedure in nicotine-dependent volunteers or current cocaine users. Cigarette smoking and IV cocaine each stimulated a rapid increase in LH and ACTH, followed by gradual increases in cortisol and DHEA. Positive subjective effects ratings increased immediately after initiation of cigarette smoking or IV cocaine administration. However, in contrast to cocaine's sustained positive effects (<20 min), ratings of "high" and "rush" began to decrease within one or two puffs of a high-nicotine cigarette while nicotine levels were increasing. Peak nicotine levels increased progressively after each of three successive cigarettes smoked at 60 min intervals, but the magnitude of the subjective effects ratings and peak ACTH and cortisol levels diminished. Only DHEA increased consistently after successive cigarettes. The possible influence of neuroactive hormones on nicotine dependence and cocaine abuse and the implications for treatment of these addictive disorders are discussed.

  9. Hormones, Nicotine and Cocaine: Clinical Studies

    PubMed Central

    Mello, Nancy K.

    2009-01-01

    Nicotine and cocaine each stimulate hypothalamic-pituitary-adrenal and -gonadal axis hormones, and there is increasing evidence that the hormonal milieu may modulate the abuse-related effects of these drugs. This review summarizes some clinical studies of the acute effects of cigarette smoking or IV cocaine on plasma drug and hormone levels, and subjective effects ratings. The temporal covariance between these dependent measures was assessed with a rapid (two min) sampling procedure in nicotine-dependent volunteers or current cocaine users. Cigarette smoking and IV cocaine each stimulated a rapid increase in LH and ACTH, followed by gradual increases in cortisol and DHEA. Positive subjective effects ratings increased immediately after initiation of cigarette smoking or IV cocaine administration. However, in contrast to cocaine’s sustained positive effects (< 20 min), ratings of “High” and “Rush” began to decrease within one or two puffs of a high nicotine cigarette while nicotine levels were increasing. Peak nicotine levels increased progressively after each of three successive cigarettes smoked at 60 min intervals, but the magnitude of the subjective effects ratings and peak ACTH and cortisol levels diminished. Only DHEA increased consistently after successive cigarettes. The possible influence of neuroactive hormones on nicotine dependence and cocaine abuse, and implications for treatment of these addictive disorders is discussed. PMID:19835877

  10. Current trends in the empirical study of cognitive remediation for schizophrenia.

    PubMed

    Saperstein, Alice M; Kurtz, Matthew M

    2013-06-01

    Cognitive remediation (CR) for schizophrenia is a learning-based behavioural skills training intervention designed to enhance neuro and (or) social cognitive skills, with the ultimate goal of generalization to improve psychosocial outcomes. This review summarizes conceptual approaches to CR for schizophrenia and the evidence for efficacy in clinical research settings. Four issues are at the forefront of ongoing research: the identification of techniques that produce the largest cognitive change, delineation of techniques that enhance transfer of cognitive skills to functional skills, the identification of CR methods that can be personalized to meet the specific cognitive and functional needs of each individual, and, all the while, ensuring that when CR methods are developed in a research setting, they remain scalable for delivery in the larger clinical community. In response to these issues, 3 prominent research trends have emerged: the rise of a new generation of computerized restorative cognitive training, the integration of CR with skills training to promote generalization, and the application of techniques to enhance motivation and learning during CR. As data on the neural basis of learning in people with schizophrenia become available, new technologies that harness the ability of the brain to make sustainable, functional changes may be integrated within a therapeutic context that promotes a personalized approach to learning. The development of transportable and scalable methods of CR that maximize the ability of people with schizophrenia to improve cognition will help them achieve personal goals for recovery.

  11. Driving factors of carbon dioxide emissions in China: an empirical study using 2006-2010 provincial data

    NASA Astrophysics Data System (ADS)

    Liu, Yu; Chen, Zhan-Ming; Xiao, Hongwei; Yang, Wei; Liu, Danhe; Chen, Bin

    2016-04-01

    The rapid urbanization of China has increased pressure on its environmental and ecological well being. In this study, the temporal and spatial profiles of China's carbon dioxide emissions are analyzed by taking heterogeneities into account based on an integration of the extended stochastic impacts using a geographically and temporally weighted regression model on population, affluence, and technology. Population size, urbanization rate, GDP per capita, energy intensity, industrial structure, energy consumption pattern, energy prices, and economy openness are identified as the key driving factors of regional carbon dioxide emissions and examined through the empirical data for 30 provinces during 2006-2010. The results show the driving factors and their spillover effects have distinct spatial and temporal heterogeneities. Most of the estimated time and space coefficients are consistent with expectation. According to the results of this study, the heterogeneous spatial and temporal effects should be taken into account when designing policies to achieve the goals of carbon dioxide emissions reduction in different regions.

  12. Driving factors of carbon dioxide emissions in China: an empirical study using 2006-2010 provincial data

    NASA Astrophysics Data System (ADS)

    Liu, Yu; Chen, Zhan-Ming; Xiao, Hongwei; Yang, Wei; Liu, Danhe; Chen, Bin

    2017-03-01

    The rapid urbanization of China has increased pressure on its environmental and ecological well being. In this study, the temporal and spatial profiles of China's carbon dioxide emissions are analyzed by taking heterogeneities into account based on an integration of the extended stochastic impacts using a geographically and temporally weighted regression model on population, affluence, and technology. Population size, urbanization rate, GDP per capita, energy intensity, industrial structure, energy consumption pattern, energy prices, and economy openness are identified as the key driving factors of regional carbon dioxide emissions and examined through the empirical data for 30 provinces during 2006‒2010. The results show the driving factors and their spillover effects have distinct spatial and temporal heterogeneities. Most of the estimated time and space coefficients are consistent with expectation. According to the results of this study, the heterogeneous spatial and temporal effects should be taken into account when designing policies to achieve the goals of carbon dioxide emissions reduction in different regions.

  13. Empirical research and logotherapy.

    PubMed

    Schulenberg, Stefan E

    2003-08-01

    The purpose of this paper was to outline suggestions for future logotherapy applications and research. Empirical studies are available on logotherapy constructs, but additional research is sorely needed. The psychometrics of logotherapy measures need to be expanded. Carefully conducted experimental studies may aid in refining long-standing logotherapy concepts and supporting or refuting new ones.

  14. Correlates of having never been HIV tested among entrants to substance abuse treatment clinics: empiric findings from real-world New England settings.

    PubMed

    Chadwick, Jeanne J; Andrade, Leonardo F; Altice, Frederick L; Petry, Nancy M

    2014-01-01

    Routine testing is the cornerstone to identifying HIV, but not all substance abuse treatment patients have been tested. This study is a real-world evaluation of predictors of having never been HIV tested among patients initiating substance abuse treatment. Participants (N = 614) from six New England clinics were asked whether they had ever been HIV tested. Eighty-five patients (13.8%) reported having never been tested and were compared to those who had undergone testing. Clinic, male gender (adjusted odds ratio (AOR) = 1.91, 95% confidence interval (CI) = 1.07-3.41), and having fewer employment (AOR = 0.31; 95% CI = 0.11-0.88) and medical problems (AOR = 0.40, 95% CI = 0.17-0.99) were independently correlated with having never been HIV tested. Thus, there is still considerable room for improved testing strategies as a clinically significant minority of substance abuse patients have never undergone HIV testing when they initiate treatment.

  15. Using Clinical Gait Case Studies to Enhance Learning in Biomechanics

    ERIC Educational Resources Information Center

    Chester, Victoria

    2011-01-01

    Clinical case studies facilitate the development of clinical reasoning strategies through knowledge and integration of the basic sciences. Case studies have been shown to be more effective in developing problem-solving abilities than the traditional lecture format. To enhance the learning experiences of students in biomechanics, clinical case…

  16. Does Teacher Quality Affect Student Achievement? An Empirical Study in Indonesia

    ERIC Educational Resources Information Center

    Sirait, Swando

    2016-01-01

    The objective of this study is to examine the relationship between teacher qualities in relation to student achievement in Indonesia. Teacher quality in this study defines as teacher evaluation score, in the areas of professional and pedagogic competency. The result of this study consonant to previous study that teacher quality, in term of teacher…

  17. Towards empirical identification of a clinically meaningful indicator of treatment outcome: Features of candidate indicators and evaluation of sensitivity to treatment effects and relationship to one year follow up cocaine use outcomes

    PubMed Central

    Carroll, Kathleen M.; Kiluk, Brian D.; Nich, Charla; DeVito, Elise E.; Decker, Suzanne; LaPaglia, Donna; Duffey, Dianne; Babuscio, Theresa A.; Ball, Samuel A.

    2014-01-01

    Background Selection of an appropriate indictor of treatment response in clinical trials is complex, particularly for the various illicit drugs of abuse. Most widely-used indicators have been selected based on expert group recommendation or convention rather than systematic empirical evaluation. Absence of an evidence-based, clinically meaningful index of treatment outcome hinders cross-study evaluations necessary for progress in addiction treatment science. Method Fifteen candidate indicators used in multiple clinical trials as well as some proposed recently are identified and discussed in terms of relative strengths and weaknesses (practicality, cost, verifiability, sensitivity to missing data). Using pooled data from five randomized controlled trials of cocaine dependence (N = 434), the indicators were compared in terms of sensitivity to the effects of treatment and relationship to cocaine use and general functioning during follow-up. Results Commonly used outcome measures (percent negative urine screens; percent days of abstinence) performed relatively well in that they were sensitive to the effects of the therapies evaluated. Others, including complete abstinence and reduction in frequency of use, were less sensitive to effects of specific therapies and were very weakly related to cocaine use or functioning during follow-up. Indicators more strongly related to cocaine use during follow-up were those that reflected achievement of sustained periods of abstinence, particularly at the end of treatment. Conclusions These analyses did not demonstrate overwhelming superiority of any single indicator, but did identify several that performed particularly poorly. Candidates for elimination included retention, complete abstinence, and indicators of reduced frequency of cocaine use. PMID:24556275

  18. Learner Autonomy in the English Classroom: Empirical Studies and Ideas for Teachers

    ERIC Educational Resources Information Center

    Lennon, Paul, Ed.

    2012-01-01

    The volume consists of twelve classroom studies concerned with the implementation of learner autonomy in English classes. The individual studies range from primary school level to university level. They include studies on multi-media dictionary work, reading logs, peer correction, communication strategies, vocabulary learning strategies, oral…

  19. Do Learning and Study Skills Affect Academic Performance?--An Empirical Investigation

    ERIC Educational Resources Information Center

    Griffin, Richard; MacKewn, Angie; Moser, Ernest; VanVuren, Ken W.

    2012-01-01

    Universities and colleges are very interested in understanding the factors that influence their students' academic performance. This paper describes a study that was conducted at a mid-sized public university in the mid-south, USA, to examine this issue. In this study, the 10-scale, Learning and Study Strategies Inventory (LASSI) (Weinstein et…

  20. A Preliminary Investigation of the Empirical Validity of Study Quality Appraisal

    ERIC Educational Resources Information Center

    Cook, Bryan G.; Dupuis, Danielle N.; Jitendra, Asha K.

    2017-01-01

    When classifying the evidence base of practices, special education scholars typically appraise study quality to identify and exclude from consideration in their reviews unacceptable-quality studies that are likely biased and might bias review findings if included. However, study quality appraisals used in the process of identifying evidence-based…

  1. Peroneal Flap: Clinical Application and Cadaveric Study

    PubMed Central

    Ha, Yooseok; Yeo, Kwan Koo; Piao, Yibo

    2017-01-01

    Background The goal of this study was to investigate the anatomy of the peroneal artery and its perforators, and to report the clinical results of reconstruction with peroneal artery perforator flaps. Methods The authors dissected 4 cadaver legs and investigated the distribution, course, origin, number, type, and length of the perforators. Peroneal artery perforator flap surgery was performed on 29 patients. Results We identified 19 perforators in 4 legs. The mean number of perforators was 4.8 per leg, and the mean length was 4.8 cm. Five perforators were found proximally, 9 medially, and 5 distally. We found 12 true septocutaneous perforators and 7 musculocutaneous perforators. Four emerged from the posterior tibia artery, and 15 were from the peroneal artery. The peroneal artery perforator flap was used in 29 patients. Retrograde island peroneal flaps were used in 8 cases, anterograde island peroneal flaps in 5 cases, and free peroneal flaps in 16 cases. The mean age was 59.9 years, and the defect size ranged from 2.0 cm×4.5 cm to 8.0 cm×8.0 cm. All the flaps survived. Five flaps developed partial skin necrosis. In 2 cases, a split-thickness skin graft was performed, and the other 3 cases were treated without any additional procedures. Conclusions The peroneal artery perforator flap is a good alternative for the reconstruction of soft tissue defects, with a constant and reliable vascular pedicle, thin and pliable skin, and the possibility of creating a composite tissue flap. PMID:28352602

  2. A Clinical Study of Electrical Accidents

    PubMed Central

    Lee, W. R.

    1961-01-01

    The report of a clinical study of 104 electrical accidents which befell 85 men is divided into two parts. Part I enumerates the different types of accidents as flash burn, Joule burn, arc eye, “held on” shock and “not held” shock, physical shock, and death. These are related to the different voltages involved ranging from 240/415 (medium) voltage to 33 kilovolts. There appeared to be no association between voltage and type of injury and no evidence to suggest that any of the voltages are free from hazard. There were 53 cases of flash burn, affecting mostly the face and extensor surface of the hands and arms. The 16 cases of arc eye caused no serious concern. Of the 15 Joule burns all except one occurred at medium voltages in “held on” accidents, the other being associated with an electric shock at 33 kilovolts. The majority of Joule burns affected the flexor surfaces. Part II of the paper deals with the 43 cases of electric shock (passage of current through the body). Thirty of these cases were “held on” to the circuit by the current. It was found that the longer a victim was held on to the circuit the greater appeared to be his chances of developing heart and chest symptoms suggestive of impending asphyxia, and of losing consciousness. Although about half of these men were released by an external agency and others struggled off, a number suddenly became free from the circuit without, they claimed, losing consciousness. This is difficult to explain. Artificial respiration was administered in two cases, one of whom was “held on” and was being asphyxiated. The other case received flash burns only and did not in fact receive an electric shock. PMID:14463581

  3. Biomass viability: An experimental study and the development of an empirical mathematical model for submerged membrane bioreactor.

    PubMed

    Zuthi, M F R; Ngo, H H; Guo, W S; Nghiem, L D; Hai, F I; Xia, S Q; Zhang, Z Q; Li, J X

    2015-08-01

    This study investigates the influence of key biomass parameters on specific oxygen uptake rate (SOUR) in a sponge submerged membrane bioreactor (SSMBR) to develop mathematical models of biomass viability. Extra-cellular polymeric substances (EPS) were considered as a lumped parameter of bound EPS (bEPS) and soluble microbial products (SMP). Statistical analyses of experimental results indicate that the bEPS, SMP, mixed liquor suspended solids and volatile suspended solids (MLSS and MLVSS) have functional relationships with SOUR and their relative influence on SOUR was in the order of EPS>bEPS>SMP>MLVSS/MLSS. Based on correlations among biomass parameters and SOUR, two independent empirical models of biomass viability were developed. The models were validated using results of the SSMBR. However, further validation of the models for different operating conditions is suggested.

  4. [Changing surgical therapy because of clinical studies?].

    PubMed

    Schwenk, W; Haase, O; Müller, J M

    2002-04-01

    The randomised controlled clinical trial (RCT) is a powerful instrument to evaluate different therapeutic regimens. In a survey among 115 physicians visiting the 25th annual meeting of the Surgical Society of Berlin and Brandenburg, the RCT was judged to be very important when changes of therapeutic strategies are discussed. 90 % of all participants claimed to use data from RCTs in the clinical routine and 89 % would participate in such a trial. In official (e. g. discussions during coffee breaks at scientific meetings) or non-medical (e. g. non-scientific press or media) sources of information were assessed as irrelevant for decisions regarding therapeutic strategies. However, in contrast to this view laparoscopic cholecystectomy was introduced into clinical practice rapidly because patients informed by external (non-medical) sources preferred to be operated on with the "modern" technique. Clinical trials with a high level of evidence had no relevant influence on the rapid distribution of laparoscopic cholecystectomy. Controversial discussions concerning the extent of lymphadenectomy with gastric resection for carcinoma demonstrate that the value of excellent clinical RCTs is low if their results challenge a stable paradigma of the surgical scientific society. To allow a rational judgement, new surgical technologies should undergo a scientific gradual evaluation in agreement with the principles of evidence based medicine.

  5. [Placebo response: in studies on pain and under other clinical conditions].

    PubMed

    Weimer, K; Horing, B; Klosterhalfen, S; Enck, P

    2011-06-01

    This contribution compares unexplained essential questions regarding the placebo response with current empirical evidence: (1) Are the placebo response rates equivalent in the groups treated with medication or placebo? Very little evidence has been gathered to support this generally accepted additivity while some findings negate its validity. (2) Is the placebo response a function of the probability of receiving medication or placebo? There are indications that the number of study groups included in a trial determines the level of placebo and medication response. (3) How great is the placebo response in trials that directly compare a (new) medication with one that for example is already on the market? There are indications that such comparative studies produce higher placebo response rates. (4) How high is the placebo response rate in everyday clinical practice--or does the response to a medication in trials substantiate the effect of the medication in everyday clinical practice?

  6. Forty-Five Years of Civil Litigation Against Canadian Psychiatrists: An Empirical Pilot Study

    PubMed Central

    Luther, Glen; Gutheil, Thomas G.

    2016-01-01

    Objectives: To extract the themes pertaining to prudent psychiatric practice from written court judgments in Canada. Methods: We searched the medical and legal literature for cases involving civil litigation against Canadian psychiatrist and reviewed all available written judgments. We completed a thematic analysis of the civil actions against psychiatrists as conveyed by those written court judgments. We classified the cases according to the disposal status and the essential lessons from the decisions on standard of care and practice by Canadian psychiatrists. Results: Forty such cases were identified as involving psychiatrists over a 45-year period. A subgroup included those dealing with limitation periods and disclosure applications. Thirty of the 40 cases (75%) were decided in favour of the defendant psychiatrists, including 2 dismissed for running over the limitation period. The cases that actually went to trial suggest that documentation and obtaining second opinions are protective against claims of negligence. Inpatient cases resulting in successful litigation against psychiatrists involved fatal outcomes, but not all fatal outcomes led to successful litigation. Conclusions: The key lessons from these cases are the importance and relevance of regular best clinical practices, such as documentation, obtaining second opinions, following guidelines, and balancing competencies in the expert and manager or advocate roles. Incorporating these practices should allay concerns about litigation against psychiatrists. PMID:27253702

  7. [Clinical studies of pediatric malabsorption syndromes].

    PubMed

    Hosoyamada, Takashi

    2006-11-01

    Multiple cases with various types of pediatric malabsorption syndromes were evaluated. The clinical manifestations, laboratory findings, pathophysiology, and histopathological descriptions of each patient were analyzed in an effort to clear the pathogenesis of the malabsorption syndromes and the treatments were undertaken. The cases studied, included one patient with cystic fibrosis, two with lactose intolerance with lactosuria (Durand type), one with primary intestinal lymphangiectasia, two with familial hypobetalipoproteinemia, one with Hartnup disease, one with congenital chroride diarrhea, one with acrodermatitis enteropathica, one with intestinal nodular lymphoid hyperplasia (NLH), five with intractable diarrhea of early infancy and four with glycogenosis type Ia. Each case description and outcome is described below: 1. A 15-year-old Japanese boy with cystic fibrosis presented with severe symptoms, including pancreatic insufficiency, bronchiectasis, pneumothorax and hemoptysis. His prognosis was poor. Analysis of the CFTR genes of this patient revealed a homozygous large deletion from intron 16 to 17b. 2. In the sibling case of Durand type lactose intolerance, the subjects'disaccaridase activity of the small bowel, including lactase, were within normal limits. The results of per oral and per intraduodenal lactose tolerance tests confirmed lactosuria in both. These observations suggested, not only an abnormal gastric condition, but also duodenal and intestinal mucosal abnormal permeability of lactose. 3. In the case of primary intestinal lymphangiectasia, the subject had a lymphedematous right arm and hand, a grossly coarsened mucosal pattern of the upper gastrointestinal tract (identified via radiologic examination) and the presence of lymphangiectasia (confirmed via duodenal mucosal biopsy). The major laboratory findings were hypoalbuminemia, decreased immunoglobulin levels and lymphopenia resulting from loss of lymph fluid and protein into the gastro

  8. An empirical study of the effectiveness of electronic stability control system in reducing loss of vehicle control.

    PubMed

    Papelis, Yiannis E; Watson, Ginger S; Brown, Timothy L

    2010-05-01

    A significant percentage of fatal vehicle crashes involve loss of control (LOC). Electronic stability control (ESC) is an active safety system that detects impending LOC and activates counter-measures that help the driver maintain or re-gain control. To assess the effectiveness of ESC in preventing LOC, an empirical study was conducted on a high-fidelity driving simulator. The ESC systems for two vehicles were incorporated into the simulator's dynamics code which was calibrated to ensure engineering validation. The study utilized three scenarios designed to recreate typical LOC situations, and was designed to assess the effects of ESC presence, vehicle type, scenario, age and gender. A total of 120 research participants completed the study. Results showed a statistically significant reduction in LOC with ESC compared to without ESC (F=52.72, p<0.0001). The study findings of 5% LOC with ESC and 30% without ESC match several epidemiological studies that have analyzed ESC effectiveness on real-world crashes, providing strong support to the use of driving simulation for studying driver behavior. Study conclusions suggest that wide-spread utilization of ESC is likely to reduce traffic fatalities.

  9. Get Your Degree from an Educational ATM: An Empirical Study in Online Education

    ERIC Educational Resources Information Center

    Lee, Y.; Nguyen, H.

    2007-01-01

    This article studies the modern trend of online education in the United States. Based on a wide range of statistics, the number of cyberspace courses offered by four-year institutions and universities nationwide has rapidly increased over the past one and a half decades. Under a case study, colleges of business from ranked universities and…

  10. Self-Efficacy, Mathematics' Anxiety and Perceived Importance: An Empirical Study with Portuguese Engineering Students

    ERIC Educational Resources Information Center

    Alves, Manuela; Rodrigues, Cristina S.; Rocha, Ana Maria A. C.; Coutinho, Clara

    2016-01-01

    The accomplishment in mathematics has gained attention from educators and arises as an emerging field of study, including in engineering education. However, in Portugal, there is still incipient research in the area; so it is high time to explore factors that might enlighten the gap in the study of the relationship between Portuguese engineering…

  11. Evaluating the Impact of an Environmental Education Programme: An Empirical Study in Mexico

    ERIC Educational Resources Information Center

    Ruiz-Mallen, Isabel; Barraza, Laura; Bodenhorn, Barbara; Reyes-Garcia, Victoria

    2009-01-01

    This study draws on information from 11 in-depth interviews, two focus groups and 72 written questionnaires to evaluate an extra-curricular environmental education programme on forestry designed for preparatory school students from a small rural community in Mexico. Specifically, the study assessed the impact of the programme on the ecological…

  12. Is Pedagogical Content Knowledge (PCK) Necessary for Reformed Science Teaching?: Evidence from an Empirical Study

    ERIC Educational Resources Information Center

    Park, Soonhye; Jang, Jeong-Yoon; Chen, Ying-Chih; Jung, Jinhong

    2011-01-01

    This study tested a hypothesis that focused on whether or not teachers' pedagogical content knowledge (PCK) is a necessary body of knowledge for reformed science teaching. This study utilized a quantitative research method to investigate the correlation between a teacher's PCK level as measured by the PCK rubric (Park et al. 2008) and the degree…

  13. Revising Basic Mathematics in a Network Environment: An Empirical Study with Finnish Technology University Students

    ERIC Educational Resources Information Center

    Ketamo, Harri; Alajaaski, Jarkko

    2008-01-01

    A revising/replenishment study course in basic mathematics is experienced as being almost a necessity at the beginning of technology studies at the Tampere University of Technology, Pori, Finland. This is to avoid early dropouts in actual engineering mathematics courses. Experimental research on factors explaining successful revision of…

  14. The IEA Six Subject Survey: An Empirical Study of Education in Twenty-One Countries.

    ERIC Educational Resources Information Center

    Walker, David A.

    The purpose of this book is to describe in nontechnical language the objectives, methods and findings of the six subject study conducted by the International Association for the Evaluation of Educational Achievement during the years 1966-1973. The six subjects covered in the study were Science, Reading Comprehension, Literature, English as a…

  15. Design Principles of Worked Examples: A Review of the Empirical Studies

    ERIC Educational Resources Information Center

    Shen, Chun-Yi; Tsai, Hui-Chun

    2009-01-01

    Many researchers investigated the efficacy of using worked examples in classroom instruction and provided evidence in the effectiveness of worked example instruction in mathematics, computer programming, physics, and etc. However, there are limited studies in worked example design. The purpose of this study is to generate the instructional design…

  16. An Empirical Study of Earth Covered Schools in Oklahoma. Final Report.

    ERIC Educational Resources Information Center

    Zaccor, James V.

    A study of earth-covered schools in Oklahoma was conducted for the Federal Emergency Management Agency (FEMA) to assess the viability of these structures as learning and teaching environments, as cost beneficial investments, and as potential shelters from natural and man-made disasters. The study was aimed at identifying what information is…

  17. Factors Influencing Entrepreneurial Intentions of Chinese Secondary School Students: An Empirical Study

    ERIC Educational Resources Information Center

    Xu, Xiaozhou; Ni, Hao; Ye, Yinghua

    2016-01-01

    The ideal stage to learn about and foster positive attitudes toward entrepreneurship is believed to be during childhood and adolescence. However, most entrepreneurial studies examine college rather than secondary school students (SSS). Based on a modified theory of planned behavior (TPB), this study used stratified cluster sampling and a…

  18. Mobile Phone Use in a Developing Country: A Malaysian Empirical Study

    ERIC Educational Resources Information Center

    Yeow, Paul H. P.; Yen Yuen, Yee; Connolly, Regina

    2008-01-01

    This study examined the factors that influence consumer satisfaction with mobile telephone use in Malaysia. The validity of the study's constructs, criterion, and content was confirmed. Construct validity was verified through the factor analysis with a total variance of 73.72 percent explained by all six independent factors. Content validity was…

  19. An Empirical Study on the Determinants of International Student Mobility: A Global Perspective

    ERIC Educational Resources Information Center

    Wei, Hao

    2013-01-01

    This paper, based on the data of 48 countries and regions from 1999 to 2008, studies the economic and educational determinants of how countries of different types attract international students. The study finds that: the volume of merchandise trade between countries facilitates international student mobility across borders; international students…

  20. A Factor Analysis on Teamwork Performance: An Empirical Study of Inter-Instituted Collaboration

    ERIC Educational Resources Information Center

    Wu, Mingchang; Chen, Ya-Hsueh

    2014-01-01

    Problem Statement: Inter-instituted collaboration has attracted broad attention for educational quality improvement in the last decade. The team performance of these innovative team projects received foremost attention, particularly with knowledge-sharing, emotional intelligence, and team conflicts. Purpose of Study: The purpose of the study was…

  1. An Empirical Study towards Understanding User Acceptance of Bring Your Own Device (BYOD) in Higher Education

    ERIC Educational Resources Information Center

    Cheng, Gary; Guan, Yuanyuan; Chau, Juliana

    2016-01-01

    This paper discusses the findings of a research study investigating user acceptance of bring your own device (BYOD) practice to support teaching and learning in a Hong Kong university. Forty-four undergraduate students and two teachers participated in the study. To collect their ratings of agreement with respect to several BYOD-related issues,…

  2. Cases for the Net Generation: An Empirical Examination of Students' Attitude toward Multimedia Case Studies

    ERIC Educational Resources Information Center

    Sheppard, Michael; Vibert, Conor

    2016-01-01

    Case studies have been an important tool in business, legal, and medical education for generations of students. Traditional text-based cases tend to be self-contained and structured in such a way as to teach a particular concept. The multimedia cases introduced in this study feature unscripted web-hosted video interviews with business owners and…

  3. Social Exclusion and Quality of Life: An Empirical Study from Turkey

    ERIC Educational Resources Information Center

    Bayram, Nuran; Bilgel, Firat; Bilgel, Nazan Gonul

    2012-01-01

    We examine the perception of social exclusion and quality of life and their interactions among a group of Turkish citizens. For this purpose we used the social exclusion scale developed by Jehoel-Gijsbers and Vrooman and the WHOQOL-BREF scale. The study group consists of 2,493 participants who are residents of a city in Turkey. Our study was based…

  4. An Empirical Study of Kirkpatrick's Evaluation Model in the Hospitality Industry

    ERIC Educational Resources Information Center

    Chang, Ya-Hui Elegance

    2010-01-01

    This study examined Kirkpatrick's training evaluation model (Kirkpatrick & Kirkpatrick, 2006) by assessing a sales training program conducted at an organization in the hospitality industry. The study assessed the employees' training outcomes of knowledge and skills, job performance, and the impact of the training upon the organization. By…

  5. Empirical Studies of the Value of Algorithm Animation in Algorithm Understanding

    DTIC Science & Technology

    1993-08-01

    A series of studies is presented using algorithm animation to teach computer algorithms . These studies are organized into three components: eliciting...lecture with experimenter-preprepared data sets. This work has implications for the design and use of animated algorithms in teaching computer algorithms and

  6. Amalgamation of Future Time Orientation, Epistemological Beliefs, Achievement Goals and Study Strategies: Empirical Evidence Established

    ERIC Educational Resources Information Center

    Phan, Huy P.

    2009-01-01

    Background: Recently research evidence emphasizes two main lines of inquiry, namely the relations between future time perspective (FTP), achievement goals (mastery, performance-approach, and performance-avoidance) and study processing strategies, and the relations between epistemological beliefs, achievement goals and study processing strategies.…

  7. Can electronic search engines optimize screening of search results in systematic reviews: an empirical study

    PubMed Central

    Sampson, Margaret; Barrowman, Nicholas J; Moher, David; Clifford, Tammy J; Platt, Robert W; Morrison, Andra; Klassen, Terry P; Zhang, Li

    2006-01-01

    Background Most electronic search efforts directed at identifying primary studies for inclusion in systematic reviews rely on the optimal Boolean search features of search interfaces such as DIALOG® and Ovid™. Our objective is to test the ability of an Ultraseek® search engine to rank MEDLINE® records of the included studies of Cochrane reviews within the top half of all the records retrieved by the Boolean MEDLINE search used by the reviewers. Methods Collections were created using the MEDLINE bibliographic records of included and excluded studies listed in the review and all records retrieved by the MEDLINE search. Records were converted to individual HTML files. Collections of records were indexed and searched through a statistical search engine, Ultraseek, using review-specific search terms. Our data sources, systematic reviews published in the Cochrane library, were included if they reported using at least one phase of the Cochrane Highly Sensitive Search Strategy (HSSS), provided citations for both included and excluded studies and conducted a meta-analysis using a binary outcome measure. Reviews were selected if they yielded between 1000–6000 records when the MEDLINE search strategy was replicated. Results Nine Cochrane reviews were included. Included studies within the Cochrane reviews were found within the first 500 retrieved studies more often than would be expected by chance. Across all reviews, recall of included studies into the top 500 was 0.70. There was no statistically significant difference in ranking when comparing included studies with just the subset of excluded studies listed as excluded in the published review. Conclusion The relevance ranking provided by the search engine was better than expected by chance and shows promise for the preliminary evaluation of large results from Boolean searches. A statistical search engine does not appear to be able to make fine discriminations concerning the relevance of bibliographic records that have

  8. Consumers' perceptions and opinions of sports injuries: an exploratory empirical study.

    PubMed

    Chandra, Ashish; Dunn, David; Paul, David P

    2008-01-01

    Millions of individuals in the United States play some sports or are involved in strenuous physical activities on a regular basis. Unfortunately, many suffer injuries due to these activities. The authors devised this study to determine consumers' perceptions and opinions associated with the injuries that they or someone they know sustained. The results of this study are beneficial to health professionals involved in preventive and rehabilitative medicine as well as sports-related protective-gear marketers.

  9. An empirical estimate of carrier frequencies for 400+ causal Mendelian variants: results from an ethnically diverse clinical sample of 23,453 individuals

    PubMed Central

    Lazarin, Gabriel A.; Haque, Imran S.; Nazareth, Shivani; Iori, Kevin; Patterson, A. Scott; Jacobson, Jessica L.; Marshall, John R.; Seltzer, William K.; Patrizio, Pasquale; Evans, Eric A.; Srinivasan, Balaji S.

    2013-01-01

    Purpose: Recent developments in genomics have led to expanded carrier screening panels capable of assessing hundreds of causal mutations for genetic disease. This new technology enables simultaneous measurement of carrier frequencies for many diseases. As the resultant rank-ordering of carrier frequencies impacts the design and prioritization of screening programs, the accuracy of this ranking is a public health concern. Methods: A total of 23,453 individuals from many obstetric, genetics, and infertility clinics were referred for routine recessive disease carrier screening. Multiplex carrier screening was performed and results were aggregated for this study. Results: Twenty-four percent of individuals were identified as carriers for at least one of 108 disorders, and 5.2% were carriers for multiple disorders. We report tabulations of carrier frequency by self-identified ethnicity and disease. Conclusion: To our knowledge, this study of a large, ethnically diverse clinical sample provides the most accurate measurements to date of carrier frequencies for hundreds of recessive alleles. The study also yields information on the clinical considerations associated with routine use of expanded panels and provides support for a pan-ethnic screening paradigm that minimizes the use of “racial” categories by the physician, as recommended by recent guidelines. PMID:22975760

  10. Toward an integrative model of doping use: an empirical study with adolescent athletes.

    PubMed

    Lazuras, Lambros; Barkoukis, Vassileios; Tsorbatzoudis, Haralambos

    2015-02-01

    The present study assessed adolescent athletes' intentions toward doping by using an integrative theoretical model. Overall, 650 adolescent athletes from team and individual sports completed an anonymous structured questionnaire including demographic information, social desirability, achievement goals, motivational regulations, sportspersonship orientations, social cognitive variables, and anticipated regret. Hierarchical regression analysis showed that the integrative model predicted 57.2% of the variance in doping intentions. Social cognitive variables and anticipated regret directly predicted doping intentions. Anticipated regret added 3% incremental variance on top of other predictors. Multiple mediation analyses showed that the effects of achievement goals on intentions were mediated by self-efficacy beliefs, whereas the effects of sportspersonship were mediated by attitudes and anticipated regret. The present study confirmed the dual structure of an integrative model of doping intentions and further highlighted the role of anticipated regret in the study of adolescent doping use.

  11. Systematic Review of the Empirical Evidence of Study Publication Bias and Outcome Reporting Bias — An Updated Review

    PubMed Central

    Dwan, Kerry; Gamble, Carrol; Williamson, Paula R.; Kirkham, Jamie J.

    2013-01-01

    Background The increased use of meta-analysis in systematic reviews of healthcare interventions has highlighted several types of bias that can arise during the completion of a randomised controlled trial. Study publication bias and outcome reporting bias have been recognised as a potential threat to the validity of meta-analysis and can make the readily available evidence unreliable for decision making. Methodology/Principal Findings In this update, we review and summarise the evidence from cohort studies that have assessed study publication bias or outcome reporting bias in randomised controlled trials. Twenty studies were eligible of which four were newly identified in this update. Only two followed the cohort all the way through from protocol approval to information regarding publication of outcomes. Fifteen of the studies investigated study publication bias and five investigated outcome reporting bias. Three studies have found that statistically significant outcomes had a higher odds of being fully reported compared to non-significant outcomes (range of odds ratios: 2.2 to 4.7). In comparing trial publications to protocols, we found that 40–62% of studies had at least one primary outcome that was changed, introduced, or omitted. We decided not to undertake meta-analysis due to the differences between studies. Conclusions This update does not change the conclusions of the review in which 16 studies were included. Direct empirical evidence for the existence of study publication bias and outcome reporting bias is shown. There is strong evidence of an association between significant results and publication; studies that report positive or significant results are more likely to be published and outcomes that are statistically significant have higher odds of being fully reported. Publications have been found to be inconsistent with their protocols. Researchers need to be aware of the problems of both types of bias and efforts should be concentrated on improving the

  12. Accumulated versus continuous exercise for health benefit: a review of empirical studies.

    PubMed

    Murphy, Marie H; Blair, Steven N; Murtagh, Elaine M

    2009-01-01

    Current physical activity guidelines endorse the notion that the recommended amount of daily physical activity can be accumulated in short bouts performed over the course of a day. Although intuitively appealing, the evidence for the efficacy of accumulated exercise is not plentiful. The purpose of this review was to compare the effects of similar amounts of exercise performed in either one continuous or two or more accumulated bouts on a range of health outcomes. Sixteen studies met the selection criteria for inclusion in the review, in which at least one outcome known to affect health was measured before and after continuous and accumulated exercise training interventions. Where improvements in cardiovascular fitness were noted, most studies reported no difference in the alterations between accumulated and continuous patterns of exercise. In the few studies where a normalization of blood pressure was observed from baseline to post-intervention, there appear to be no differences between accumulated and continuous exercise in the magnitude of this effect. For other health outcomes such as adiposity, blood lipids and psychological well-being, there is insufficient evidence to determine whether accumulated exercise is as effective as the more traditional continuous approach. Seven short-term studies in which at least one health-related outcome was measured during the 0- to 48-hour period after a single continuous bout of exercise and a number of short bouts of equivalent total duration were included in the review. Many of the studies of such short-term effects considered the plasma triglyceride response to a meal following either accumulated short or continuous bouts of exercise. Collectively, these studies suggest that accumulated exercise may be as effective at reducing postprandial lipaemia. Further research is required to determine if even shorter bouts of accumulated exercise (<10 minutes) confer a health benefit and whether an accumulated approach to physical

  13. Empirical study of a unidirectional dense crowd during a real mass event

    NASA Astrophysics Data System (ADS)

    Zhang, X. L.; Weng, W. G.; Yuan, H. Y.; Chen, J. G.

    2013-06-01

    Many tragic crowd disasters have happened across the world in recent years, such as the Phnom Penh stampede in Cambodia, crowd disaster in Mina/Makkah, and the Love Parade disaster in Germany, showing that management of mass events is a tough task for organizers. The study of unidirectional flow, one of the most common forms of motion in mass activities, is essential for safe organization of such events. In this paper, the properties of unidirectional flow in a crowded street during a real mass event in China are quantitatively investigated with sophisticated active infrared counters and an image processing method. A complete dataset of flow rates during the whole celebration is recorded, and a time series analysis gives new insight into such activities. The spatial analysis shows that the velocity and density of the crowd are inhomogeneous due to the boundary effect, whereas the flux is uniform. The estimated capacity of the street indicates that the maximum flow rate under normal condition should be between 1.73 and 1.98 /m/s, which is in good agreement with several field studies available in the existing literature. In consideration of the significant deviation among different studies, fundamental diagrams of dense crowds are also re-verified, and the results here are consistent with those from other field studies of unidirectional flow, but different from the bidirectional and experimental results. It is suggested that the data from multidirectional flow and experiments cannot be directly applied to unidirectional dense flow in a real mass event. The results also imply that the density of a similar unidirectional marching crowd should be controlled to be under 5 /m2, which can produce optimal efficiency and have more possibility to ensure safety. The field study data given here provide a good example of a database for crowd studies.

  14. Visual Task Demands and the Auditory Mismatch Negativity: An Empirical Study and a Meta-Analysis

    PubMed Central

    Wiens, Stefan; Szychowska, Malina; Nilsson, Mats E.

    2016-01-01

    Because the auditory system is particularly useful in monitoring the environment, previous research has examined whether task-irrelevant, auditory distracters are processed even if subjects focus their attention on visual stimuli. This research suggests that attentionally demanding visual tasks decrease the auditory mismatch negativity (MMN) to simultaneously presented auditory distractors. Because a recent behavioral study found that high visual perceptual load decreased detection sensitivity of simultaneous tones, we used a similar task (n = 28) to determine if high visual perceptual load would reduce the auditory MMN. Results suggested that perceptual load did not decrease the MMN. At face value, these nonsignificant findings may suggest that effects of perceptual load on the MMN are smaller than those of other demanding visual tasks. If so, effect sizes should differ systematically between the present and previous studies. We conducted a selective meta-analysis of published studies in which the MMN was derived from the EEG, the visual task demands were continuous and varied between high and low within the same task, and the task-irrelevant tones were presented in a typical oddball paradigm simultaneously with the visual stimuli. Because the meta-analysis suggested that the present (null) findings did not differ systematically from previous findings, the available evidence was combined. Results of this meta-analysis confirmed that demanding visual tasks reduce the MMN to auditory distracters. However, because the meta-analysis was based on small studies and because of the risk for publication biases, future studies should be preregistered with large samples (n > 150) to provide confirmatory evidence for the results of the present meta-analysis. These future studies should also use control conditions that reduce confounding effects of neural adaptation, and use load manipulations that are defined independently from their effects on the MMN. PMID:26741815

  15. The behavioral consequences of service quality: an empirical study in the Chinese retail pharmacy industry.

    PubMed

    Chen, Yuwen; Fu, Frank Q

    2015-01-01

    This study focuses on the impacts of service quality and examines the mediating effects of customer satisfaction and customer loyalty on willingness to pay more. The authors collected survey data from 479 actual retail pharmacy customers in China and used the structural equation modeling approach to test the hypotheses. The results reveal six dimensions of service quality and the differential impact of these dimensions on customer satisfaction and behavioral intentions. This study contributes to the existing literature by exploring the dimensionality of the service quality construct and mediating effects of customer satisfaction and customer loyalty in a non-Western setting.

  16. Empirical Study of Motivators and Barriers of Teacher Online Knowledge Sharing

    ERIC Educational Resources Information Center

    Hew, Khe Foon; Hara, Noriko

    2007-01-01

    The focus of this study was to understand knowledge flows among teachers by examining what types of knowledge was shared by teachers, as well as what motivates or hinders teachers to share knowledge online. We examined an electronic mailing list (listserv) supporting a community of practice of literacy teachers. Data were gathered on the teachers…

  17. High Performance Work System, HRD Climate and Organisational Performance: An Empirical Study

    ERIC Educational Resources Information Center

    Muduli, Ashutosh

    2015-01-01

    Purpose: This paper aims to study the relationship between high-performance work system (HPWS) and organizational performance and to examine the role of human resource development (HRD) Climate in mediating the relationship between HPWS and the organizational performance in the context of the power sector of India. Design/methodology/approach: The…

  18. An Empirical Study on the Role of Context Factors in Employees' Commitment to Change

    ERIC Educational Resources Information Center

    Soumyaja, Devi; Kamlanabhan, T. J.; Bhattacharyya, Sanghamitra

    2011-01-01

    The study attempts to address the gap of exploring the possible antecedents of employees' commitment to change and its three dimensions. The role of context factors--participation in decision making, quality of communication, trust in management and history of change--are tested on overall commitment to change and also on its three…

  19. An Empirical Study Examining the Impact of Gambling Advertisements on Adolescent Gambling Attitudes and Behaviors

    ERIC Educational Resources Information Center

    Derevensky, Jeffrey; Sklar, Alissa; Gupta, Rina; Messerlian, Carmen

    2010-01-01

    Based upon a previous qualitative study a questionnaire ascertaining adolescents' awareness of gambling advertisements and their impact upon their behavior was developed and administered to 1,147 youth between the ages of 12 and 19. The findings suggest that almost all youth report being exposed to advertising with many individuals indicating…

  20. Application of Open-Source Enterprise Information System Modules: An Empirical Study

    ERIC Educational Resources Information Center

    Lee, Sang-Heui

    2010-01-01

    Although there have been a number of studies on large scale implementation of proprietary enterprise information systems (EIS), open-source software (OSS) for EIS has received limited attention in spite of its potential as a disruptive innovation. Cost saving is the main driver for adopting OSS among the other possible benefits including security…

  1. Activity Learning and Learning Activity: Discussions of a Concept, and an Outline for an Empirical Study.

    ERIC Educational Resources Information Center

    Hallden, Ola

    This paper is a first report from the project "Activity Learning and Cooperation," financed by the Swedish Board of Education. The aim of the project is to establish a theoretical basis for a field study of locally initiated experiments using various teaching strategies. More specifically, this paper is restricted to a discussion of the…

  2. The Linguistic Advantage of the Intellectually Gifted Child: An Empirical Study of Spontaneous Speech

    ERIC Educational Resources Information Center

    Hoh, Pau-San

    2005-01-01

    This study compares the linguistic development of a gifted bilingual child from birth to 7 with that of subjects in first language acquisition research. The aspects analyzed are phonology, morphology (word formation), lexicon, modality (encoding of speaker's attitude towards the truthfulness of a proposition), syntax (sentence construction),…

  3. An Empirical Study of Hospitality Management Student Attitudes toward Group Projects: Instructional Factors and Team Problems

    ERIC Educational Resources Information Center

    Choi, Youngsoo; Ro, Heejung

    2012-01-01

    The development of positive attitudes in team-based work is important in management education. This study investigates hospitality students' attitudes toward group projects by examining instructional factors and team problems. Specifically, we examine how the students' perceptions of project appropriateness, instructors' support, and evaluation…

  4. An Empirical Study on Behavioural Intention to Reuse E-Learning Systems in Rural China

    ERIC Educational Resources Information Center

    Li, Yan; Duan, Yanqing; Fu, Zetian; Alford, Philip

    2012-01-01

    The learner's acceptance of e-learning systems has received extensive attention in prior studies, but how their experience of using e-learning systems impacts on their behavioural intention to reuse those systems has attracted limited research. As the applications of e-learning are still gaining momentum in developing countries, such as China,…

  5. Attitudes towards the Euro: An Empirical Study Based on the German Socio-Economic Panel (SOEP)

    ERIC Educational Resources Information Center

    Isengard, Bettina; Schneider, Thorsten

    2007-01-01

    This paper investigates changing attitudes towards the euro over time in Germany using longitudinal micro-data from the German Socio Economic Panel Study. We observe that a large part of the German population was worried about the new currency both before and after its introduction. Social psychological theories provide insight into these…

  6. Exploration of Social Capital and Knowledge Sharing: An Empirical Study on Student Virtual Teams

    ERIC Educational Resources Information Center

    Liu, Ying Chieh; Li, FengChia

    2012-01-01

    Although research on virtual teams is becoming more popular, there is a gap in the understanding of how social capital affects knowledge sharing and creating, and their impacts on virtual team performance. To fill in this gap, this study establishes a framework by incorporating social capital with the SECI model and further examines it with an…

  7. A Survey and Empirical Study of Virtual Reference Service in Academic Libraries

    ERIC Educational Resources Information Center

    Mu, Xiangming; Dimitroff, Alexandra; Jordan, Jeanette; Burclaff, Natalie

    2011-01-01

    Virtual Reference Services (VRS) have high user satisfaction. The main problem is its low usage. We surveyed 100 academic library web sites to understand how VRS are presented. We then conducted a usability study to further test an active VRS model regarding its effectiveness.

  8. Relationship between Running Speed and Cognitive Processes in Orienteering: Two Empirical Studies.

    ERIC Educational Resources Information Center

    Cheshikhina, Valentina V.

    1993-01-01

    Fourteen qualified orienteers completed a stepwise increased treadmill velocity test in which controls had to be transferred from a master map. Orienteering accuracy was greatest at the anaerobic threshold speed. In a second study, 17 orienteers performed arithmetic tasks before and after a treadmill workout. Performance was significantly better…

  9. An Empirical Typology of Residential Care/Assisted Living Based on a Four-State Study

    ERIC Educational Resources Information Center

    Park, Nan Sook; Zimmerman, Sheryl; Sloane, Philip D.; Gruber-Baldini, Ann L.; Eckert, J. Kevin

    2006-01-01

    Purpose: Residential care/assisted living describes diverse facilities providing non-nursing home care to a heterogeneous group of primarily elderly residents. This article derives typologies of assisted living based on theoretically and practically grounded evidence. Design and Methods: We obtained data from the Collaborative Studies of Long-Term…

  10. Impact of Multi-Media Tutorials in a Computer Science Laboratory Course--An Empirical Study

    ERIC Educational Resources Information Center

    Dalal, Medha

    2014-01-01

    Higher education institutes of North America, Europe and far-east Asia have been leveraging the advances in ICT for quite some time. However, research based knowledge on the use of ICT in the higher education institutes of central and south-east Asia is still not readily available. The study presented in this paper explores a variant of teaching…

  11. Religion and Traditional Values in Public School Textbooks: An Empirical Study.

    ERIC Educational Resources Information Center

    Vitz, Paul C.

    This section, from a larger report describing a project designed to systematically investigate how religious and traditional values are represented in today's public school curricula, presents seven studies intended to examine how religion, religious values, and family and family values are presented in the typical textbooks used in the nation's…

  12. Product and Process Perspectives: an Empirical Study of Explicitation in Chinese-English Translation

    ERIC Educational Resources Information Center

    Fan, Zhewei

    2012-01-01

    Product-and process-oriented, this dissertation focuses on both the explicitness in translated texts and the implementation of explicitation in Chinese-English translation. In doing so, it provides a new cognitive framework for understanding explicitation as a strategic process. A specially designed study of the translation process facilitates the…

  13. Maternal Identity of Hearing Mothers of Deaf Adolescents. Empirical Studies: An Interpersonal Approach

    ERIC Educational Resources Information Center

    Kobosko, Joanna; Zalewska, Marina

    2011-01-01

    The maternal identity of mothers of adolescents who are deaf has certain specific features compared with mothers of adolescents who have typical hearing. That is, maternal identity differs with respect to distinctiveness, self-representation, and representation of mother-child relationships. A study using a comparative paradigm was conducted. The…

  14. Assessing Mobile Learning Readiness in Saudi Arabia Higher Education: An Empirical Study

    ERIC Educational Resources Information Center

    Aljuaid, Nada Mansour F.; Alzahrani, Mohammed Ali Rajab; Islam, A. Y. M. Atiquil

    2014-01-01

    Mobile learning has been introduced for quite some time now at Taif University. However, there is no research conducted to measure the readiness of mobile learning within its context. As such, the aim of this study is to assess the lecturers' readiness for mobile learning in higher education in terms of perceived usefulness and perceived ease of…

  15. Emotional Competencies in Geriatric Nursing: Empirical Evidence from a Computer Based Large Scale Assessment Calibration Study

    ERIC Educational Resources Information Center

    Kaspar, Roman; Hartig, Johannes

    2016-01-01

    The care of older people was described as involving substantial emotion-related affordances. Scholars in vocational training and nursing disagree whether emotion-related skills could be conceptualized and assessed as a professional competence. Studies on emotion work and empathy regularly neglect the multidimensionality of these phenomena and…

  16. The Effects of Resilience Training on Secondary Traumatic Stress Reactions: An Empirical Study

    ERIC Educational Resources Information Center

    Shew, Allison M.

    2010-01-01

    The goal of this study was to determine the effectiveness of vicarious resiliency training. Data was collected from 25 professionals who are at high risk for developing vicarious trauma and who attended a 3-day resiliency training presented by Henry Tobey in Denver, Colorado. A pre, post, and follow-up design were employed where all participants…

  17. The Relationship between Individual Characteristics and Ideation Behavior: An Empirical Study of Storyboards

    ERIC Educational Resources Information Center

    Teng, Pei-Shan; Cai, Dengchuan; Yu, Tai-Kuei

    2014-01-01

    The development of digital technology tool and the progress of animation design activities have led to great progress in the animation field. The storyboard is a type of media used to present animator ideas. Therefore, it is commonly viewed as fundamental to the animation industry. This study aims to discuss cognitive style- and gender-based…

  18. Comparing Achievement between K-8 and Middle Schools: A Large-Scale Empirical Study

    ERIC Educational Resources Information Center

    Byrnes, Vaughan; Ruby, Allen

    2007-01-01

    This study compares middle schools to K-8 schools, as well as to newly formed K-8 schools that are part of a K-8 conversion policy. The outcome is student achievement, and our sample includes 40,883 eighth-grade students from 95 schools across five cohorts. The analysis uses multilevel modeling to account for student, cohort, and school-level…

  19. Organizational Justice: Personality Traits or Emotional Intelligence? An Empirical Study in an Italian Hospital Context

    ERIC Educational Resources Information Center

    Di Fabio, Annamaria; Palazzeschi, Letizia

    2012-01-01

    The purpose of this study was to investigate the role of personality traits and emotional intelligence in relation to organizational justice. The Organizational Justice Scale, the Eysenck Personality Questionnaire-Revised Short Form, and the Bar-On Emotional Quotient Inventory were administered to 384 Italian nurses. The emotional intelligence…

  20. An Empirical Study of Post-Branzburg Cases Involving Newsmen's Privilege.

    ERIC Educational Resources Information Center

    Mehra, Achal

    Nine years after the 1972 Supreme Court ruling in *Branzburg v. Hayes" that journalists enjoy no constitutional privilege to withhold the names of sources and to conceal information from grand jury proceedings, a study was conducted to determine the courts' attitudes toward journalists' privilege and to test commonly held beliefs about its…

  1. Cognitive Load Theory: An Empirical Study of Anxiety and Task Performance in Language Learning

    ERIC Educational Resources Information Center

    Chen, I-Jung; Chang, Chi-Cheng

    2009-01-01

    Introduction: This study explores the relationship among three variables--cognitive load, foreign language anxiety, and task performance. Cognitive load refers to the load imposed on working memory while performing a particular task. The authors hypothesized that anxiety consumes the resources of working memory, leaving less capacity for cognitive…

  2. Technology Readiness of School Teachers: An Empirical Study of Measurement and Segmentation

    ERIC Educational Resources Information Center

    Badri, Masood; Al Rashedi, Asma; Yang, Guang; Mohaidat, Jihad; Al Hammadi, Arif

    2014-01-01

    The Technology Readiness Index (TRI) developed by Parasuraman (2000) was adapted to measure the technology readiness of public school teachers in Abu Dhabi, United Arab Emirates. The study aims at better understanding the factors (mostly demographics) that affect such readiness levels. In addition, Abu Dhabi teachers are segmented into five main…

  3. An Empirical Approach to Salary Discrimination: With Case Study of Sex Discrimination in Education

    ERIC Educational Resources Information Center

    Anderson, Julie A.; Murphy, Norman C.

    1977-01-01

    A statistical method to determine sex discrimination in salaries considered known differential variables which can legitimately be used to determine salary level apart from discrimination based on improper criteria, such as race, sex, religion, etc. This case study of a group of educators exemplifies salary discrimination based on sex. (Author/MV)

  4. Contributions to the Empirical Study of Immediacy in the Pedagogical Relationship through Self-Narratives

    ERIC Educational Resources Information Center

    Manarte, Joana; Lopes, Amélia; Pereira, Fátima

    2014-01-01

    Pedagogical communication is an action wherein the body, being a part of a relational whole, performs a fundamental role. A bibliographical survey of studies on the interaction between teacher and student confirms that there is a strong correlation between the teacher's nonverbal behavior and the students' level of motivation and…

  5. Online Learning in Management Education: An Empirical Study of the Role of Personality Traits

    ERIC Educational Resources Information Center

    Varela, Otmar E.; Cater, John James, III; Michel, Norbert

    2012-01-01

    In this study we seek to better understand the outcomes of online education by observing the role of learners' personality traits. Under the premise that the behaviors that maximize learning are contingent on the delivery method, we compared learning outcomes of students participating in four sections of an undergraduate principles of management…

  6. An Empirical Study on the Application of Cooperative Learning to English Listening Classes

    ERIC Educational Resources Information Center

    Han, Min

    2015-01-01

    Cooperative learning is a strategic instructional system applied by many educators the world over. Researchers of cooperative learning have carried out the study in this field and proved that cooperative learning can create a more interesting and relaxed learning atmosphere. It is generally acknowledged that cooperative learning can reduce…

  7. Identity Dystopias, Empire Framing and Theoretical Hegemonies: Two Case Studies, India and Ireland

    ERIC Educational Resources Information Center

    Allender, Tim; O'Donoghue, Tom

    2014-01-01

    This article explores the connections between official contemporary identity formation and colonial pasts. Using the case studies of India and Ireland the article explores how different traditions of theorisation are powerful in these formations. India and Ireland were two colonial domains that had many linkages outside the ambit of the British.…

  8. The Importance of Civic Responsibility in Higher Performing Middle Schools: An Empirical Study

    ERIC Educational Resources Information Center

    Wilcox, Kristen C.

    2011-01-01

    In this case study, a district-wide focus on the development of civic responsibility is seen as an important component in the success of higher performing middle schools. Salient features of best practice were gathered from teacher and administrator interviews and documentary evidence in 10 higher performing, yet "beating the odds" schools, and…

  9. Variations of In-Service Training for Primary Mathematics Teachers: An Empirical Study

    ERIC Educational Resources Information Center

    Selter, Christoph; Gräsel, Cornelia; Reinold, Martin; Trempler, Kati

    2015-01-01

    Previous findings indicate that the effectiveness of in-service teacher training can be increased by a (pedagogical) content knowledge orientation on the one hand and the stimulation of cooperation among teachers on the other. In this paper, three versions of a multi-phase training program were compared in a quasi-experimental field study with a…

  10. Studies on Written Corrective Feedback: Theoretical Perspectives, Empirical Evidence, and Future Directions

    ERIC Educational Resources Information Center

    Wang, Ting; Jiang, Lin

    2015-01-01

    The role of written corrective feedback (WCF) in the process of acquiring a second language (L2) has been an issue of considerable controversies over past decades. This article intends to provide a critical review of the increasing number of WCF studies thus far and to inspire new perspectives for future research. It starts by briefly tracing the…

  11. An Empirical Research Study of the Efficacy of Two Plagiarism-Detection Applications

    ERIC Educational Resources Information Center

    Hill, Jacob D.; Page, Elaine Fetyko

    2009-01-01

    This article describes a study of the two most popular plagiarism-detection software platforms available on today's market--Turnitin (http://www.turnitin.com/static/index.html) and SafeAssign (http://www.safeassign.com/). After a brief discussion of plagiarism's relevance to librarians, the authors examine plagiarism-detection methodology and…

  12. Presidential Satisfaction in Higher Education: An Empirical Study of Two- and Four-Year Institutions

    ERIC Educational Resources Information Center

    Perrakis, Athena I.; Galloway, Fred J.; Hayes, Kacy K.; Robinson-Galdo, Karen

    2011-01-01

    Situated in the broader context of academic administration and senior executive university leadership, this study examined variables correlated with self-reported satisfaction and performance among community college and four-year university presidents in four densely populated north American states. The results of our analysis suggest that…

  13. Construct Validity of the GRE Aptitude Test across Populations--An Empirical Confirmatory Study.

    ERIC Educational Resources Information Center

    Rock, D. A.; And Others

    The study evaluated the invariance of the construct validity and thus the interpretation of Graduate Record Examinations (GRE) Aptitude Test scores. A systematic procedure for investigation of test bias from a construct validity frame of reference was developed and applied. Invariant construct validity was defined as similar patterns of loadings…

  14. An Empirical Study of the Personality Characteristics of Internet Sex Offenders

    ERIC Educational Resources Information Center

    Tomak, Sheri; Weschler, Frederick S.; Ghahramanlou-Holloway, Marjan; Virden, Thomas; Nademin, Mahsaw Elicia

    2009-01-01

    The present study evaluated the personality characteristics and psychopathology of internet sex offenders (ISOs) using the Minnesota Multiphasic Personality Inventory, Second Edition (MMPI-2) to determine whether ISO personality profiles are different to those of general sex offenders (GSOs; e.g. child molesters and rapists). The ISOs consisted of…

  15. An Empirical Study of the Role of Output in Promoting the Acquisition of Linguistic Forms

    ERIC Educational Resources Information Center

    Song, Zhaojuan

    2010-01-01

    This study examines the effectiveness of an output practice, i.e., Chinese-to-English translation, on promoting noticing and acquisition of a type of grammatical form, i.e., lexical phrases. It is confirmed that output is vital in facilitating learners' noticing and acquisition of the targeted linguistic forms.

  16. An Empirical Study of the Factors Affecting Weblog Success in Higher Education

    ERIC Educational Resources Information Center

    Zhang, Sonya

    2013-01-01

    The use of classroom blogs in higher education serves to engage and motivate students as well as to help them build a professional online profile and connect with fellow classmates. Although many studies have focused on the implementation and benefits of blogging in education, few have investigated best practices in design, which can have a…

  17. An Empirical Study of Industrial Engineering and Management Curriculum Reform in Fostering Students' Creativity

    ERIC Educational Resources Information Center

    Chen, Chi-Kuang; Jiang, Bernard C.; Hsu, Kuang-Yiao

    2005-01-01

    The objective of this paper is to examine the effectiveness of a creativity-fostering program in industrial engineering and management (IE&M) curriculum reform. Fostering creativity in students has become a crucial issue in industrial engineering education. In a survey of previous studies, we found few on IE&M curriculum reform. In…

  18. Do Digital Natives Differ by Computer Self-Efficacy and Experience? An Empirical Study

    ERIC Educational Resources Information Center

    Teo, Timothy

    2016-01-01

    This study serves to validate a Chinese translation of the Digital Native Assessment Scale (C-DNAS) and assess if significant differences exist between a sample of students and teachers from a culture different than the one used in the development of the DNAS. Participants were 402 university students from one province in Mainland China. Results…

  19. L2 vs. L1 Use of Synonymy: An Empirical Study of Synonym Use/Acquisition

    ERIC Educational Resources Information Center

    Liu, Dilin; Zhong, Shouman

    2016-01-01

    Synonymy is important but difficult for language learners to grasp. Using a forced-choice question instrument, along with corpus data as reference, this study examines the use of four sets of synonyms by intermediate/advanced Chinese EFL/ESL learners and native English speakers. The data analyses reveal several key findings, including a general…

  20. Generic Behavioural Criteria of Managerial Effectiveness: An Empirical and Comparative Case Study of UK Local Government

    ERIC Educational Resources Information Center

    Hamlin, Robert G.; Serventi, Susan A.

    2008-01-01

    Purpose: The purpose of this paper is to present the findings of a "partnership-research" study of effective and ineffective managerial behaviour within the "local government" setting of the Wolverhampton City Council Social Care Department, and to describe how the research supports and challenges the organisation's existing…

  1. Communication Privacy Disclosure Management: An Empirical Study of Socialization Support in a Pseudo-Online Course

    ERIC Educational Resources Information Center

    Heo, Misook

    2011-01-01

    This study investigated the boundaries of online learners' information disclosure, relationship building, interpersonal integration, and motivation by drawing upon the theoretical frameworks of the social information processing and communication privacy management theories and the hyperpersonal model. A total of 103 students from a higher…

  2. Effects of Annotations and Homework on Learning Achievement: An Empirical Study of Scratch Programming Pedagogy

    ERIC Educational Resources Information Center

    Su, Addison Y. S.; Huang, Chester S. J.; Yang, Stephen J. H.; Ding, T. J.; Hsieh, Y. Z.

    2015-01-01

    In Taiwan elementary schools, Scratch programming has been taught for more than four years. Previous studies have shown that personal annotations is a useful learning method that improve learning performance. An annotation-based Scratch programming (ASP) system provides for the creation, share, and review of annotations and homework solutions in…

  3. Social Interaction and Adolescent's Learning in Enterprise Education: An Empirical Study

    ERIC Educational Resources Information Center

    Man, Thomas Wing Yan; Yu, Christina Wai Mui

    2007-01-01

    Purpose: The purpose of this study is to investigate the impact of social interaction on participants' learning experience in enterprise education. Design/methodology/approach: On a sample of 420 high school students who participated in an enterprise activity in Hong Kong, two questionnaires surveys were conducted to collect data on them at the…

  4. An Empirical Evaluation of Critical Factors Influencing Learner Satisfaction in Blended Learning: A Pilot Study

    ERIC Educational Resources Information Center

    Chen, Won Sun; Yao, Adrian Yong Tat

    2016-01-01

    Blended learning, a convergence of e-learning approach and face-to-face learning, has been regarded as a new paradigm in modern education. The degree of learners' satisfaction with blended learning played a crucial role in evaluating the effectiveness of blended learning adoption. Therefore, this study examined the primary factors affecting…

  5. The Role of Structural Characteristics in Problematic Video Game Play: An Empirical Study

    ERIC Educational Resources Information Center

    King, Daniel L.; Delfabbro, Paul H.; Griffiths, Mark D.

    2011-01-01

    The research literature suggests that the structural characteristics of video games may play a considerable role in the initiation, development and maintenance of problematic video game playing. The present study investigated the role of structural characteristics in video game playing behaviour within a sample of 421 video game players aged…

  6. An Empirical Study on Business English Teaching and Development in China--A Needs Analysis Approach

    ERIC Educational Resources Information Center

    Guiyu, Dai; Yang, Liu

    2016-01-01

    This paper first reviews the developmental history and status quo of Business English Program in China. Then based on the theory of needs analysis, it researches on 226 questionnaires from Business English Program students from Guangdong University of Foreign Studies to investigate the problems encountered and current situation of Business English…

  7. The Efficiency of Different Online Learning Media--An Empirical Study

    ERIC Educational Resources Information Center

    Köbler, Franziska J.; Nitzschner, Marco M.

    2014-01-01

    In the current study, it was examined whether successful learning is related to using different types of media. We compared the comprehension of an economic concept in novices (N = 82) under three conditions: a Wikipedia article, a funny, and a serious YouTube video. The media were presented in English which is a foreign language to most of the…

  8. Sex Ratio at Birth and Infant Mortality Rate in China: An Empirical Study

    ERIC Educational Resources Information Center

    Lai, Denjian

    2005-01-01

    In this article, we used the data from the last three population censuses of China in 1982, 1990 and 2000, to study the dynamics of the sex ratio at birth and the infant mortality rate in China. In the late 1970s, China started its economic reform and implemented many family planning programs. Since then there has been great economic development…

  9. The Relationship of Teacher-Personality Type to Grading Freshman Composition Essays: An Empirical Study.

    ERIC Educational Resources Information Center

    Covner, Thelma Crockin

    To gain insight into the evaluation of college freshman compositions, a study explored the relationship between the personality type of the instructor and the grades assigned to essays written by freshman composition students. The sample comprised 23 college instructors who answered a short questionnaire, graded the same expository essay, and…

  10. Students' Perceptions of a Scaffolded Approach to Learning Financial Planning: An Empirical Study

    ERIC Educational Resources Information Center

    Cull, Michelle; Davis, Glenda

    2013-01-01

    In the aftermath of the global financial crisis (GFC), one understandable area of scrutiny and pressure for reform is the educational background and professionalism of personal financial advisers. This Australian study reports on a three-year investigation into students' perceptions of "scaffolded" instruction in financial planning. The…

  11. An Empirical Study of Instructor Adoption of Web-Based Learning Systems

    ERIC Educational Resources Information Center

    Wang, Wei-Tsong; Wang, Chun-Chieh

    2009-01-01

    For years, web-based learning systems have been widely employed in both educational and non-educational institutions. Although web-based learning systems are emerging as a useful tool for facilitating teaching and learning activities, the number of users is not increasing as fast as expected. This study develops an integrated model of instructor…

  12. A Meta-Analysis of Motivational Interviewing: Twenty-Five Years of Empirical Studies

    ERIC Educational Resources Information Center

    Lundahl, Brad W.; Kunz, Chelsea; Brownell, Cynthia; Tollefson, Derrik; Burke, Brian L.

    2010-01-01

    Objective: The authors investigated the unique contribution motivational interviewing (MI) has on counseling outcomes and how MI compares with other interventions. Method: A total of 119 studies were subjected to a meta-analysis. Targeted outcomes included substance use (tobacco, alcohol, drugs, marijuana), health-related behaviors (diet,…

  13. Development of Phonological Awareness in down Syndrome: A Meta-Analysis and Empirical Study

    ERIC Educational Resources Information Center

    Naess, Kari-Anne B.

    2016-01-01

    Phonological awareness (PA) is the knowledge and understanding of the sound structure of language and is believed to be an important skill for the development of reading. This study explored PA skills in children with Down syndrome and matched typically developing (TD) controls using a dual approach: a meta-analysis of the existing international…

  14. Assessment in Early Primary Education: An Empirical Study of Five School Contexts

    ERIC Educational Resources Information Center

    DeLuca, Christopher; Hughes, Scott

    2014-01-01

    Within the current standards-based framework of early primary education, teachers must negotiate the integration of assessment with traditional, developmental orientations to teaching and learning. The purpose of this qualitative study was to examine teachers' approaches to early primary assessment within five different school contexts: public,…

  15. Examining Antecedents of Knowledge-Sharing Factors on Research Supervision: An Empirical Study

    ERIC Educational Resources Information Center

    Khosravi, Arash; Ahmad, Mohammad Nazir

    2016-01-01

    The use of an effective supervision mechanism is crucial between a student and supervisor. The essential knowledge shared and transferred between these two parties must be observed and understood very well in order to ensure that students are produced at good level of quality for future professional knowledge workers. The aim of this study was to…

  16. Are You Ready for Knowledge Sharing? An Empirical Study of Virtual Communities

    ERIC Educational Resources Information Center

    Hung, Shiu-Wan; Cheng, Min-Jhih

    2013-01-01

    This study aimed to explore the relationship between knowledge sharing intentions and the perceptions of individual technology users who are members of virtual communities. We characterized learners' perceptions of new technological products or services by including both an individual's psychological state of readiness to accept technology and…

  17. The Relationship between Global Competence and Language Learning Motivation: An Empirical Study in Critical Language Classrooms

    ERIC Educational Resources Information Center

    Semaan, Gaby; Yamazaki, Kasumi

    2015-01-01

    This article examines the relationship between global competence and second language learning motivation in critical language classrooms. Data were collected from 137 participants who were studying critical languages (Arabic, Chinese, Japanese, Korean, Persian) at two universities on the East and West Coasts of the United States, using a 30-item…

  18. Effects of Female Education on Economic Growth: A Cross Country Empirical Study

    ERIC Educational Resources Information Center

    Oztunc, Hakan; Oo, Zar Chi; Serin, Zehra Vildan

    2015-01-01

    This study examines the extent to which women's education affects long-term economic growth in the Asia Pacific region. It focuses on the time period between 1990 and 2010, using data collected in randomly selected Asia Pacific countries: Bangladesh, Cambodia, China, India, Indonesia, Lao PDR, Malaysia, Myanmar, Philippines, Thailand, and Vietnam.…

  19. Discourse Markers in College English Listening Instruction: An Empirical Study of Chinese Learners

    ERIC Educational Resources Information Center

    Zhang, Jianfeng

    2012-01-01

    Discourse markers can clearly indicate the organization of discourse, remind the hearer of the preceding and the following contents, and express clearly the concrete speech acts. The aims of this study are to explore the relationship between the discourse-marker-based model and listening comprehension as well as the different effects of such a…

  20. Assessing the Usability of University Websites: An Empirical Study on Namik Kemal University

    ERIC Educational Resources Information Center

    Mentes, S. Ahmet; Turan, Aykut H.

    2012-01-01

    Web sites are emerging as a key component of an organization's survival in our ever globalizing competitive world. Usability of a web site has assumed a great deal of importance in terms of satisfying web site users' needs and expectations. The aim of the study is to evaluate and to explore the usability level of Namik Kemal University (NKU)…