Sample records for close window mayo

  1. Philosophy of Research in Motor Speech Disorders

    ERIC Educational Resources Information Center

    Weismer, Gary

    2006-01-01

    The primary objective of this position paper is to assess the theoretical and empirical support that exists for the Mayo Clinic view of motor speech disorders in general, and for oromotor, nonverbal tasks as a window to speech production processes in particular. Literature both in support of and against the Mayo clinic view and the associated use…

  2. Find a Brain Tumor Center

    MedlinePlus

    ... Ways to Give Charitable Shopping Close Find a Brain Tumor Center Below is a listing of brain ... center is in your insurance plan’s covered network Brain Tumor Treatment Centers: Filter: Mayo Clinic Arizona Mayo ...

  3. HLA Genes in Mayos Population from Northeast Mexico

    PubMed Central

    Arnaiz-Villena, A; Moscoso, J; Granados, J; Serrano-Vela, J.I; de la Peña, A.; Reguera, R; Ferri, A; Seclen, E; Izaguirre, R; Perez-Hernandez, N; Vargas-Alarcon, G

    2007-01-01

    HLA class I and class II alleles have been studied in 60 unrelated people belonging to Mayos ethnic group, which lives in the Mexican Pacific Sinaloa State. Mayos HLA profile was compared to other Amerindians and worldwide populations’ profile. A total of 14,896 chromosomes were used for comparisons. Genetic distances between populations, Neigbour-Joining dendrograms and correspondence analyses were performed to determine the genetic relationship among population. The new specific Mayo HLA haplotypes found are: HLA-A*02-B*35-DRB1*1406-DQB1*0301; HLA-A*02-B*48-DRB1*0404-DQB1*0302; HLA-A*24-B*51-DRB1*0407-DQB1*0302 and HLA-A*02-B*08-DRB1*0407-DQB1*0302. However, the typical Meso American HLADRB1*0407 represents a 40% of all DRB1 alleles. While common HLA characteristics are found in Amerindian distant ethnic groups, still new group specific HLA haplotypes are being found, suggesting that a common founder effect (i.e. high DRB1*0407) is noticed. Moreover, new HLA haplotypes are almost certainly appearing along time probably due to specific pathogen (?) selection for diversity. Mayo language is close to the Tarahumara one (another geographically close group); notwithstanding both groups are not genetically close according to our results, showing again the different evolution of genes and languages, which do not correlate. Finally, Sinaloa is one of the Mexican States in which more European genes are found. However, the results presented in this paper, where no European HLA genes are seen in Mayos, should have a bearing in establishing transplant programs and in HLA and disease studies. PMID:19412332

  4. Closing the Education Gap: A Mayo Clinic Approach to Academic Achievement.

    ERIC Educational Resources Information Center

    Sang, Herb A.

    Despite recent efforts to provide equal education, agreement exists that blacks, females, and disadvantaged students as a group are outperformed in mathematics and science by white middle-class students. To help disadvantaged students, the Duval County Public Schools (Jacksonville, Florida) have developed a "Mayo Clinic" approach to…

  5. Stress Management: Social Support

    MedlinePlus

    Healthy Lifestyle Stress management Having close friends and family has far-reaching benefits for your health. Here's how to build and maintain these ... article: http://www.mayoclinic.org/healthy-lifestyle/stress-management/in-depth/social-support/art-20044445 . Mayo Clinic ...

  6. The December 2012 Mayo River debris flow triggered by Super Typhoon Bopha in Mindanao, Philippines: lessons learned and questions raised

    NASA Astrophysics Data System (ADS)

    Rodolfo, Kelvin S.; Lagmay, A. Mahar F.; Eco, Rodrigo C.; Herrero, Tatum Miko L.; Mendoza, Jerico E.; Minimo, Likha G.; Santiago, Joy T.

    2016-12-01

    Category 5 Super Typhoon Bopha, the world's worst storm of 2012, formed abnormally close to the Equator, and its landfall on Mindanao set the record proximity to the Equator for its category. Its torrential rains generated an enormous debris flow in the Mayo River watershed that swept away much of the village Andap in the New Bataan municipality, burying areas under rubble as thick as 9 m and killing 566 people. Established in 1968, New Bataan had never experienced super typhoons and debris flows. This unfamiliarity compounded the death and damage. We describe Bopha's history, debris flows and the Mayo River disaster, and then we discuss how population growth contributed to the catastrophe, as well as the possibility that climate change may render other near-Equatorial areas vulnerable to hazards brought on by similar typhoons. Finally, we recommend measures to minimize the loss of life and damage to property from similar future events.

  7. New Parents: How to Get the Sleep You Need

    MedlinePlus

    ... these strategies to fit more sleep into your days and nights. By Mayo Clinic Staff It's 2 a.m. ... Avoid nicotine, caffeine and alcohol late in the day or at night. Get regular physical activity — not too close to ...

  8. Window-closing safety system

    DOEpatents

    McEwan, Thomas E.

    1997-01-01

    A safety device includes a wire loop embedded in the glass of a passenger car window and routed near the closing leading-edge of the window. The wire loop carries microwave pulses around the loop to and from a transceiver with separate output and input ports. An evanescent field only and inch or two in radius is created along the wire loop by the pulses. Just about any object coming within the evanescent field will dramatically reduce the energy of the microwave pulses received back by the transceiver. Such a loss in energy is interpreted as a closing area blockage, and electrical interlocks are provided to halt or reverse a power window motor that is actively trying to close the window.

  9. Window-closing safety system

    DOEpatents

    McEwan, T.E.

    1997-08-26

    A safety device includes a wire loop embedded in the glass of a passenger car window and routed near the closing leading-edge of the window. The wire loop carries microwave pulses around the loop to and from a transceiver with separate output and input ports. An evanescent field only an inch or two in radius is created along the wire loop by the pulses. Just about any object coming within the evanescent field will dramatically reduce the energy of the microwave pulses received back by the transceiver. Such a loss in energy is interpreted as a closing area blockage, and electrical interlocks are provided to halt or reverse a power window motor that is actively trying to close the window. 5 figs.

  10. [Preventive effects of sound insulation windows on the indoor noise levels in a street residential building in Beijing].

    PubMed

    Guo, Bin; Huang, Jing; Guo, Xin-biao

    2015-06-18

    To evaluate the preventive effects of sound insulation windows on traffic noise. Indoor noise levels of the residential rooms (on both the North 4th ring road side and the campus side) with closed sound insulation windows were measured using the sound level meter, and comparisons with the simultaneously measured outdoor noise levels were made. In addition, differences of indoor noise levels between rooms with closed sound insulation windows and open sound insulation windows were also compared. The average outdoor noise levels of the North 4th ring road was higher than 70 dB(A), which exceeded the limitation stated in the "Environmental Quality Standard for Noise" (GB 3096-2008) in our country. However, with the sound insulation windows closed, the indoor noise levels reduced significantly to the level under 35 dB(A) (P<0.05), which complied with the indoor noise level standards in our country. The closed or open states of the sound insulation windows had significant influence on the indoor noise levels (P<0.05). Compared with the open state of the sound insulation window, when the sound insulation windows were closed, the indoor noise levels reduced 18.8 dB(A) and 8.3 dB(A) in residential rooms facing North 4th ring road side and campus side, respectively. The results indicated that installation of insulation windows had significant noise reduction effects on street residential buildings especially on the rooms facing major traffic roads. Installation of the sound insulation windows has significant preventive effects on indoor noise in the street residential building.

  11. Surgeon-nurse anesthetist collaboration advanced surgery between 1889 and 1950.

    PubMed

    Koch, Bruce Evan

    2015-03-01

    To meet the need for qualified anesthetists, American surgeons recruited nurses to practice anesthesia during the Civil War and in the latter half of the 19th century. The success of this decision led them to collaborate with nurses more formally at the Mayo Clinic in Minnesota. During the 1890s, Alice Magaw refined the safe administration of ether. Florence Henderson continued her work improving the safety of ether administration during the first decade of the 20th century. Safe anesthesia enabled the Mayo surgeons to turn the St. Mary's Hospital into a surgical powerhouse. The prominent surgeon George Crile collaborated with Agatha Hodgins at the Lakeside Hospital in Cleveland to introduce nitrous oxide/oxygen anesthesia. Nitrous oxide/oxygen caused less cardiovascular depression than ether and thus saved the lives of countless trauma victims during World War I. Crile devised "anoci-association," an outgrowth of nitrous oxide/oxygen anesthesia. Hodgins' use of anoci-association made Crile's thyroid operations safer. Pioneering East Coast surgeons followed the lead of the surgeons at Mayo. William Halsted worked closely with Margaret Boise, and Harvey Cushing worked closely with Gertrude Gerard. As medicine became more complex, collaboration between surgeons and nurse anesthetists became routine and necessary. Teams of surgeons and nurse anesthetists advanced thoracic, cardiovascular, and pediatric surgery. The team of Evarts Graham and Helen Lamb performed the world's first pneumonectomy. Surgeon-nurse anesthetist collaboration seems to have been a uniquely American phenomenon. This collaboration facilitated both the "Golden Age of Surgery" and the profession we know today as nurse anesthesia.

  12. Madonna della Pietá by Michelangelo.

    PubMed

    Wentz, Margaret R

    2018-05-01

    Recognizing the contribution art has had in the Mayo Clinic environment since the original Mayo Clinic Building was finished in 1914, Mayo Clinic Proceedings features some of the numerous works of art displayed throughout the buildings and grounds on Mayo Clinic campuses as interpreted by the author. Copyright © 2018 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc. All rights reserved.

  13. Chilkat Ceremonial Dancing Blanket - Circa 1870s.

    PubMed

    Wentz, Margaret R

    2017-05-01

    Recognizing the contribution art has had in the Mayo Clinic environment since the original Mayo Clinic Building was finished in 1914, Mayo Clinic Proceedings features some of the numerous works of art displayed throughout the buildings and grounds on Mayo Clinic campuses as interpreted by the author. Copyright © 2017 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc. All rights reserved.

  14. The founding of the Mayo School of Graduate Medical Education.

    PubMed

    Boes, Christopher J; Long, Timothy R; Rose, Steven H; Fye, W Bruce

    2015-02-01

    The Mayo Foundation for Medical Education and Research (hereafter the Mayo Foundation), the precursor to the Mayo School of Graduate Medical Education, was incorporated in 1915. The Mayo Foundation, which was affiliated with the University of Minnesota Graduate School, aimed to establish a higher standard for training medical specialists. Together, the University of Minnesota and the Mayo Foundation pioneered a graduate medical education program that allowed residents to earn master's and PhD degrees in clinical medicine and surgery. Unlike elsewhere in the United States, the residency training program was not pyramidal. (In a pyramidal residency program, each training year, some residents are systematically eliminated to reduce the number of more senior trainees.) All those who started the Mayo Foundation residency program had an opportunity to finish depending on their own merits. Louis B. Wilson, the first director of the Mayo Foundation, became a major figure in graduate medical education in the 1920s and 1930s. Although the granting of graduate degrees in medicine and surgery stopped over time, Mayo Clinic ultimately became the largest site of graduate medical education in the world. Copyright © 2015 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc. All rights reserved.

  15. Differences between Outdoor and Indoor Sound Levels for Open, Tilted, and Closed Windows.

    PubMed

    Locher, Barbara; Piquerez, André; Habermacher, Manuel; Ragettli, Martina; Röösli, Martin; Brink, Mark; Cajochen, Christian; Vienneau, Danielle; Foraster, Maria; Müller, Uwe; Wunderli, Jean Marc

    2018-01-18

    Noise exposure prediction models for health effect studies normally estimate free field exposure levels outside. However, to assess the noise exposure inside dwellings, an estimate of indoor sound levels is necessary. To date, little field data is available about the difference between indoor and outdoor noise levels and factors affecting the damping of outside noise. This is a major cause of uncertainty in indoor noise exposure prediction and may lead to exposure misclassification in health assessments. This study aims to determine sound level differences between the indoors and the outdoors for different window positions and how this sound damping is related to building characteristics. For this purpose, measurements were carried out at home in a sample of 102 Swiss residents exposed to road traffic noise. Sound pressure level recordings were performed outdoors and indoors, in the living room and in the bedroom. Three scenarios-of open, tilted, and closed windows-were recorded for three minutes each. For each situation, data on additional parameters such as the orientation towards the source, floor, and room, as well as sound insulation characteristics were collected. On that basis, linear regression models were established. The median outdoor-indoor sound level differences were of 10 dB(A) for open, 16 dB(A) for tilted, and 28 dB(A) for closed windows. For open and tilted windows, the most relevant parameters affecting the outdoor-indoor differences were the position of the window, the type and volume of the room, and the age of the building. For closed windows, the relevant parameters were the sound level outside, the material of the window frame, the existence of window gaskets, and the number of windows.

  16. The Irish glaciated margin: processes and environments of deglaciation.

    NASA Astrophysics Data System (ADS)

    McCarron, Stephen; Monteys, Xavier; Scott, Gill

    2015-04-01

    High resolution bathymetric data for Donegal Bay and parts of the western Irish Continental Shelf have become available in recent years due to the Irish National Seabed Survey [INSS] (2000-2009). Relative to onshore glacigenic landform preservation and visibility on the shelf and on the floor of Donegal Bay is excellent. Here we describe some of the the data, paying particular attention to the area close to the north Mayo coastline. We discuss inferred connections between well exposed and age constrained glacial geology along the coastal fringe and the submarine evidence of deglcial processes and timing. It is argued that the sediment and landform assemblage within the Bay is derived from multiple, lobate extensions of the last British Irish Ice Sheet into the Donegal Bay topographic low from source areas to the southeast (north Mayo) and east/northeast (Sligo and Donegal/Fermanagh) during overall deglaciation (Termination 1).

  17. A new rapid quantitative test for fecal calprotectin predicts endoscopic activity in ulcerative colitis.

    PubMed

    Lobatón, Triana; Rodríguez-Moranta, Francisco; Lopez, Alicia; Sánchez, Elena; Rodríguez-Alonso, Lorena; Guardiola, Jordi

    2013-04-01

    Fecal calprotectin (FC) determined by the enzyme-linked immunosorbent assay (ELISA) test has been proposed as a promising biomarker of endoscopic activity in ulcerative colitis (UC). However, data on its accuracy in predicting endoscopic activity is scarce. Besides, FC determined by the quantitative-point-of-care test (FC-QPOCT) that provides rapid and individual results could optimize its use in clinical practice. The aims of our study were to evaluate the ability of FC to predict endoscopic activity according to the Mayo score in patients with UC when determined by FC-QPOCT and to compare it with the ELISA test (FC-ELISA). FC was determined simultaneously by FC-ELISA and FC-QPOCT in patients with UC undergoing colonoscopy. Clinical disease activity and endoscopy were assessed according to the Mayo score. Blood tests were taken to analyze serological biomarkers. A total of 146 colonoscopies were performed on 123 patients with UC. FC-QPOCT correlated more closely with the Mayo endoscopic subscore (Spearman's correlation coefficient rank r = 0.727, P < 0.001) than clinical activity (r = 0.636, P < 0.001), platelets (r = 0.381, P < 0.001), leucocytes (r = 0.300, P < 0.001), and C-reactive protein (r = 0.291, P = 0.002). The prediction of "endoscopic remission" (Mayo endoscopic subscore ≤1) with FC-QPOCT (280 µg/g) and FC-ELISA (250 µg/g) presented an area under the curve of 0.906 and 0.924, respectively. The interclass correlation index between both tests was 0.904 (95% confidence interval, 0.864-0.932; P < 0.001). FC determined by QPOCT was an accurate surrogate marker of "endoscopic remission" in UC and presented a good correlation with the FC-ELISA test.

  18. The origins of the modern pain clinic at the Mayo Clinic.

    PubMed

    Weingarten, Toby N; Martin, David P; Bacon, Douglas R

    2011-07-01

    In the 1970s the practice of pain management evolved from the isolated anesthesiologist practicing pain "on the side" to a multi-disciplinary model. The impetus behind this change remains obscure. To understand how this national trend occurred locally and to examine national institutional challenges which should be reflected at the Mayo Clinic that stimulated the establishment of a modern academic pain practice, we interviewed appropriate staff members and reviewed relevant departmental meeting notes. Following the 1959 departure of Dr. John Lundy from Mayo, Dr. Robert Jones became the primary practitioner of pain procedures in addition to his anesthesiology practice. In 1973, close to his retirement, Jones wrote a letter to the department chairman, Dr. Richard Theye, expressing frustration because this divided practice hindered patient care, education, and research opportunities. In 1974 Dr. Lee Nauss joined Mayo upon residency completion at Virginia Mason where he received training in regional anesthesia and met Dr. John Bonica. Nauss introduced epidural steroid injections, which became in such great demand that other anesthesiologists needed to cover his rooms. Within two months, Theye asked Nauss to create a stand-alone pain clinic. Nauss recruited Dr. Tony Wang and opened the clinic that year. This pain clinic increased patient access, improved resident education, allowed for the establishment of a fellowship program, and produced ground-breaking research (e.g., the human administration of intrathecal morphine). The establishment of the pain clinic addressed the deficiencies of a mixed pain and anesthesia practice. The pain specialist could now focus attention on and provide better access for pain patients, keep current with clinical practice, engage in research, and educate future pain specialists.

  19. 13. Detail, typical window with fireproof shutters closed, northeast rear, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    13. Detail, typical window with fireproof shutters closed, northeast rear, view to southwest, 135mm lens. Note cracks evidencing structural failure. - Benicia Arsenal, Powder Magazine No. 5, Junction of Interstate Highways 680 & 780, Benicia, Solano County, CA

  20. Differences between Outdoor and Indoor Sound Levels for Open, Tilted, and Closed Windows

    PubMed Central

    Locher, Barbara; Piquerez, André; Habermacher, Manuel; Ragettli, Martina; Cajochen, Christian; Vienneau, Danielle; Foraster, Maria; Müller, Uwe; Wunderli, Jean Marc

    2018-01-01

    Noise exposure prediction models for health effect studies normally estimate free field exposure levels outside. However, to assess the noise exposure inside dwellings, an estimate of indoor sound levels is necessary. To date, little field data is available about the difference between indoor and outdoor noise levels and factors affecting the damping of outside noise. This is a major cause of uncertainty in indoor noise exposure prediction and may lead to exposure misclassification in health assessments. This study aims to determine sound level differences between the indoors and the outdoors for different window positions and how this sound damping is related to building characteristics. For this purpose, measurements were carried out at home in a sample of 102 Swiss residents exposed to road traffic noise. Sound pressure level recordings were performed outdoors and indoors, in the living room and in the bedroom. Three scenarios—of open, tilted, and closed windows—were recorded for three minutes each. For each situation, data on additional parameters such as the orientation towards the source, floor, and room, as well as sound insulation characteristics were collected. On that basis, linear regression models were established. The median outdoor–indoor sound level differences were of 10 dB(A) for open, 16 dB(A) for tilted, and 28 dB(A) for closed windows. For open and tilted windows, the most relevant parameters affecting the outdoor–indoor differences were the position of the window, the type and volume of the room, and the age of the building. For closed windows, the relevant parameters were the sound level outside, the material of the window frame, the existence of window gaskets, and the number of windows. PMID:29346318

  1. A comprehensive information technology system to support physician learning at the point of care.

    PubMed

    Cook, David A; Sorensen, Kristi J; Nishimura, Rick A; Ommen, Steve R; Lloyd, Farrell J

    2015-01-01

    MayoExpert is a multifaceted information system integrated with the electronic medical record (EMR) across Mayo Clinic's multisite health system. It was developed as a technology-based solution to manage information, standardize clinical practice, and promote and document learning in clinical contexts. Features include urgent test result notifications; models illustrating expert-approved care processes; concise, expert-approved answers to frequently asked questions (FAQs); a directory of topic-specific experts; and a portfolio for provider licensure and credentialing. The authors evaluate MayoExpert's reach, effectiveness, adoption, implementation, and maintenance. Evaluation data sources included usage statistics, user surveys, and pilot studies.As of October 2013, MayoExpert was available at 94 clinical sites in 12 states and contained 1,368 clinical topics, answers to 7,640 FAQs, and 92 care process models. In 2012, MayoExpert was accessed at least once by 2,578/3,643 (71%) staff physicians, 900/1,374 (66%) midlevel providers, and 1,728/2,291 (75%) residents and fellows. In a 2013 survey of MayoExpert users with 536 respondents, all features were highly rated (≥67% favorable). More providers reported using MayoExpert to answer questions before/after than during patient visits (68% versus 36%). During November 2012 to April 2013, MayoExpert sent 1,660 notifications of new-onset atrial fibrillation and 1,590 notifications of prolonged QT. MayoExpert has become part of routine clinical and educational operations, and its care process models now define Mayo Clinic best practices. MayoExpert's infrastructure and content will continue to expand with improved templates and content organization, new care process models, additional notifications, better EMR integration, and improved support for credentialing activities.

  2. Performance of the Mayo-IBM PAC system

    NASA Astrophysics Data System (ADS)

    Persons, Kenneth R.; Reardon, Frank J.; Gehring, Dale G.; Hangiandreou, Nicholas J.

    1994-05-01

    The Mayo Clinic and IBM (at Rochester, Minnesota) have jointly developed a picture archived system for use with Mayo's MRI and CT imaging modalities. This PACS is made up of over 50 computers that work cooperatively to provide archival, retrieval and image distribution services for Mayo's Department of Radiology. This paper will examine the performance characteristics of the system.

  3. Strength Training: For Overall Fitness

    MedlinePlus

    ... Medical Education and Research; 2016. AskMayoExpert. Strength training: Benefits. Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2016. AskMayoExpert. Strength training: Strategies for ...

  4. Breast Biopsy

    MedlinePlus

    ... time If your biopsy will be done using magnetic resonance imaging (MRI), tell your doctor if you ... org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation ...

  5. 10 CFR 452.5 - Bidding procedures.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... cellulosic biofuels producers during the open window established in the solicitation. The open window shall.... (d) All bids will be confidential until 45 days after the close of the window for submission of bids... following: (1) After DOE evaluates the bids received during the open window, it shall, within 45 days...

  6. Vagus Nerve Stimulation

    MedlinePlus

    ... before you have any medical tests, such as magnetic resonance imaging (MRI), which might interfere with your ... org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation ...

  7. Phantom Pain

    MedlinePlus

    ... cord and brain. During imaging scans — such as magnetic resonance imaging (MRI) or positron emission tomography (PET) — ... org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation ...

  8. Documentation of debris impact damage to flight deck window

    NASA Image and Video Library

    1995-07-26

    STS070-309-026 (13-22 JULY 1995) --- A close-up view of the space shuttle Discovery?s window number 6, on the forward starboard side, nearest the pilot?s station. A small impact in the window, about 1/16 inch in size, is clearly seen in the corner. Crew members told a August 11, 1995, gathering of Johnson Space Center (JSC) employees that a small piece of debris apparently struck the window during Discovery?s wing velocity vector mode. It was noticed when the astronauts awoke from their sleep period. Though watched closely during the remainder of the mission, the impact never caused a major concern.

  9. Urinary Tract Infection

    MedlinePlus

    ... contribute to bacterial growth. By Mayo Clinic Staff . Mayo Clinic Footer Legal Conditions and Terms Any use of ... Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds ...

  10. Tailbone Pain: How Can I Relieve It?

    MedlinePlus

    ... any other conditions. Your doctor might recommend using magnetic resonance imaging (MRI) to find out if you ... org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation ...

  11. Breast Lump: Early Evaluation Is Essential

    MedlinePlus

    ... is solid or filled with fluid. MRI. A magnetic field and radio waves create detailed images of ... org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation ...

  12. The Mayo Clinic Author Catalog: A Living Repository of Medical Knowledge

    PubMed Central

    Key, Jack D.; Sholtz, Katherine J.

    1973-01-01

    Since 1907 records have been kept of publications by staff members of the Mayo Clinic, and this information has been invaluable. The Author Catalog has proved itself such a useful tool for the Mayo Clinic that other libraries, large and small, may wish to consider adopting such a service. The Mayo medical complex is a large institution with more than 500 staff and faculty members engaged in the publication of clinical, educational, and research findings. The great amount of cross-disciplinary cooperation and interdepartmental research makes essential an up-to-date record of what is going on. The Mayo Clinic Library developed a comprehensive computerized method for identifying research and for identifying and indexing publications of Mayo staff members. At the end of 1971 more than 25,000 citations had been stored on computer tape. Images PMID:4122094

  13. The Power of Effective Design in e-Learning: A Study of the "Mayo Effect" Video

    ERIC Educational Resources Information Center

    Fan, Jiang Ping

    2014-01-01

    When the Mayo Effect video went live on the Mayo intranet in June 2010, it was very well received at Mayo Clinic. The message in the video was so effectively delivered that it became an instant sensation across the institution. The video contains about 461 words. In such a short video, every part of its architectural design, whether it is visual,…

  14. Optimization of wide-area ATM and local-area ethernet/FDDI network configurations for high-speed telemedicine communications employing NASA's ACTS.

    PubMed

    McDermott, W R; Tri, J L; Mitchell, M P; Levens, S P; Wondrow, M A; Huie, L M; Khandheria, B K; Gilbert, B K

    1999-01-01

    A high data rate terrestrial and satellite network was implemented to transfer medical images and data. This article describes the a optimization of the workstations and switching equipment incorporated into the network. Topics discussed in this article include tuning of the network software, the configuration of the Sun Microsystems workstations, the FORE Systems asynchronous transfer mode switches, as well as the throughput results of two telemedicine experiments undertaken by Mayo's physician staff. The technical staff was successful in achieving the data throughput needed by the telemedicine software; particularly important was the proper determination of peak throughput and TCP window sizes to ensure optimum use of the resources available on the Sun Microsystems and Hewlett Packard workstations.

  15. A preliminary human factors planning and design outline of parameters related to space station windows and CCTV monitoring

    NASA Technical Reports Server (NTRS)

    Haines, R. F.

    1985-01-01

    The question of the merits of placing windows on proposed future space stations is addressed. The use of windows for human visual capabilities is compared to using closed circuit television. Placement and field of view, as well as the number of windows is discussed.

  16. Mini-Stroke vs. Regular Stroke: What's the Difference?

    MedlinePlus

    ... may need various diagnostic tests, such as a magnetic resonance imaging (MRI) scan or a computerized tomography ( ... org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation ...

  17. MRI: Is Gadolinium Safe for People with Kidney Problems?

    MedlinePlus

    ... M.D. It depends on the type of magnetic resonance imaging (MRI) scan you're scheduled to ... org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation ...

  18. Reflective insulating blinds for windows and the like

    DOEpatents

    Barnes, P.R.; Shapira, H.B.

    1979-12-07

    Energy-conserving window blinds are provided. The blinds are fabricated from coupled and adjustable slats, each slat having an insulation layer and a reflective surface to face outwardly when the blinds are closed. A range of desired light and air transmission may be selected with the reflective surfaces of the slats adapted to direct sunlight upward toward the ceiling when the blinds are open. When the blinds are closed, the insulation of the slats reduces the heat loss or gain produced by the windows. If desired, the reflective surfaces of the slats may be concave. The edges of the slats are designed to seal against adjacent slats when the blinds are closed to ensure minimum air flow between slats.

  19. Reflective insulating blinds for windows and the like

    DOEpatents

    Barnes, Paul R.; Shapira, Hanna B.

    1981-01-01

    Energy-conserving window blinds are provided. The blinds are fabricated from coupled and adjustable slats, each slat having an insulation layer and a reflective surface to face outwardly when the blinds are closed. A range of desired light and air transmission may be selected with the reflective surfaces of the slats adapted to direct sunlight upward toward the ceiling when the blinds are open. When the blinds are closed, the insulation of the slats reduces the heat loss or gain produced by the windows. If desired, the reflective surfaces of the slats may be concave. The edges of the slats are designed to seal against adjacent slats when the blinds are closed to ensure minimum air flow between slats.

  20. Personal exposure to fine particulate air pollution while commuting: An examination of six transport modes on an urban arterial roadway.

    PubMed

    Chaney, Robert A; Sloan, Chantel D; Cooper, Victoria C; Robinson, Daniel R; Hendrickson, Nathan R; McCord, Tyler A; Johnston, James D

    2017-01-01

    Traffic-related air pollution in urban areas contributes significantly to commuters' daily PM2.5 exposures, but varies widely depending on mode of commuting. To date, studies show conflicting results for PM2.5 exposures based on mode of commuting, and few studies compare multiple modes of transportation simultaneously along a common route, making inter-modal comparisons difficult. In this study, we examined breathing zone PM2.5 exposures for six different modes of commuting (bicycle, walking, driving with windows open and closed, bus, and light-rail train) simultaneously on a single 2.7 km (1.68 mile) arterial urban route in Salt Lake City, Utah (USA) during peak "rush hour" times. Using previously published minute ventilation rates, we estimated the inhaled dose and exposure rate for each mode of commuting. Mean PM2.5 concentrations ranged from 5.20 μg/m3 for driving with windows closed to 15.21 μg/m3 for driving with windows open. The estimated inhaled doses over the 2.7 km route were 6.83 μg for walking, 2.78 μg for cycling, 1.28 μg for light-rail train, 1.24 μg for driving with windows open, 1.23 μg for bus, and 0.32 μg for driving with windows closed. Similarly, the exposure rates were highest for cycling (18.0 μg/hr) and walking (16.8 μg/hr), and lowest for driving with windows closed (3.7 μg/hr). Our findings support previous studies showing that active commuters receive a greater PM2.5 dose and have higher rates of exposure than commuters using automobiles or public transportation. Our findings also support previous studies showing that driving with windows closed is protective against traffic-related PM2.5 exposure.

  1. Personal exposure to fine particulate air pollution while commuting: An examination of six transport modes on an urban arterial roadway

    PubMed Central

    Sloan, Chantel D.; Cooper, Victoria C.; Robinson, Daniel R.; Hendrickson, Nathan R.; McCord, Tyler A.; Johnston, James D.

    2017-01-01

    Traffic-related air pollution in urban areas contributes significantly to commuters’ daily PM2.5 exposures, but varies widely depending on mode of commuting. To date, studies show conflicting results for PM2.5 exposures based on mode of commuting, and few studies compare multiple modes of transportation simultaneously along a common route, making inter-modal comparisons difficult. In this study, we examined breathing zone PM2.5 exposures for six different modes of commuting (bicycle, walking, driving with windows open and closed, bus, and light-rail train) simultaneously on a single 2.7 km (1.68 mile) arterial urban route in Salt Lake City, Utah (USA) during peak “rush hour” times. Using previously published minute ventilation rates, we estimated the inhaled dose and exposure rate for each mode of commuting. Mean PM2.5 concentrations ranged from 5.20 μg/m3 for driving with windows closed to 15.21 μg/m3 for driving with windows open. The estimated inhaled doses over the 2.7 km route were 6.83 μg for walking, 2.78 μg for cycling, 1.28 μg for light-rail train, 1.24 μg for driving with windows open, 1.23 μg for bus, and 0.32 μg for driving with windows closed. Similarly, the exposure rates were highest for cycling (18.0 μg/hr) and walking (16.8 μg/hr), and lowest for driving with windows closed (3.7 μg/hr). Our findings support previous studies showing that active commuters receive a greater PM2.5 dose and have higher rates of exposure than commuters using automobiles or public transportation. Our findings also support previous studies showing that driving with windows closed is protective against traffic-related PM2.5 exposure. PMID:29121096

  2. Biopsy: Types of Biopsy Procedures Used to Diagnose Cancer

    MedlinePlus

    ... procedure — such as X-ray, computerized tomography (CT), magnetic resonance imaging (MRI) or ultrasound — with a needle ... org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation ...

  3. Medication Errors: Cut Your Risk with These Tips

    MedlinePlus

    ... program. Reporting to MedWatch is easy, confidential and secure — and it can help save others from being ... org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation ...

  4. Glossary | Efficient Windows Collaborative

    Science.gov Websites

    double-hung windows as a means of counterbalancing the weight of the sash during opening and closing. Bay a fixed sash or a double-hung window. Also referred to as bead stop. Blackbody. The ideal, perfect member of the lower sash which meet at the middle of a double-hung window. Clerestory. A window in the

  5. Development of Assays for Detecting Significant Prostate Cancer Based on Molecular Alterations Associated with Cancer in Non-Neoplastic Prostate Tissue

    DTIC Science & Technology

    2015-10-01

    with Cancer in Non-Neoplastic Prostate Tissue PRINCIPAL INVESTIGATOR: Farhad Kosari, Ph.D. CONTRACTING ORGANIZATION: Mayo Clinic Rochester, MN...E-Mail: kosari.farhad@mayo.edu 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Mayo Clinic Rochester, MN 55905-0002 8...with the Tissue Request Acquisition Group (TRAG) at the Mayo Clinic , a process was implemented for the collection of resected prostates from

  6. Elton Mayo and Carl Rogers: A Tale of Two Techniques.

    ERIC Educational Resources Information Center

    Mahoney, Kevin T.; Baker, David B.

    2002-01-01

    Compares the simultaneous emergence of Mayo's nonauthoritarian interviewing approach and Rogers' nondirective counseling approach. Examines the influence of Piaget on Mayo and reviews the Hawthorne studies. Concludes that differences in the approaches outweigh similarities. (Contains 21 references.) (SK)

  7. Microsatellite analyses of the trout of northwest Mexico

    USGS Publications Warehouse

    Nielsen, J.L.; Sage, G.K.

    2001-01-01

    The trout of northwest Mexico represent an undescribed group of fish considered part of the Oncorhynchus mykiss (Pacific trout) complex of species and subspecies. Recent genetic studies have shown these fish to have important genetic diversity and a unique evolutionary history when compared to coastal rainbow trout. Increased levels of allelic diversity have been found in this species at the southern extent of its range. In this study we describe the trout in the Sierra Madre Occidental from the rios Yaqui, Mayo, Casas Grandes and de Bavispe, and their relationship to the more southern distribution of Mexican golden trout (O. chrysogaster) using 11 microsatellite loci. Microsatellite allelic diversity in Mexican trout was high with a mean of 6.6 alleles/locus, average heterozygosity = 0.35, and a mean Fst = 0.43 for all loci combined. Microsatellite data were congruent with previously published mtDNA results showing unique panmictic population structure in the Rio Yaqui trout that differs from Pacific coastal trout and Mexican golden trout. These data also add support for the theory of headwaters transfer of trout across the Continental Divide from tributaries of the Rio de Bavispe into the Rio Casas Grandes. Rio Mayo trout share a close genetic relationship to trout in Rio Yaqui, but sample sizes from the Rio Mayo prevent significant comparisons in this study. Microsatellite analyses show significant allelic frequency differences between Rio Yaqui trout and O. chrysogaster in Sinaloa and Durango Mexico, adding further support for a unique evolutionary status for this group of northwestern Mexican trout.

  8. Evaluation of the Risk of Relapse in Ulcerative Colitis According to the Degree of Mucosal Healing (Mayo 0 vs 1): A Longitudinal Cohort Study.

    PubMed

    Barreiro-de Acosta, Manuel; Vallejo, Nicolau; de la Iglesia, Daniel; Uribarri, Laura; Bastón, Iria; Ferreiro-Iglesias, Rocío; Lorenzo, Aurelio; Domínguez-Muñoz, J Enrique

    2016-01-01

    Mucosal healing in ulcerative colitis (UC) has become a common endpoint in most clinical trials and a relevant therapeutic goal in clinical practice. Despite important differences between endoscopic Mayo scores 0 and 1, both scores are considered as mucosal healing in most important trials. The aim of the present study was to evaluate the risk of relapse in UC patients according to the degree of mucosal healing (endoscopic Mayo scores of 0 and 1). A prospective longitudinal cohort study was designed. All UC patients who presented with mucosal healing at colonoscopy were consecutively included. Mucosal healing was defined as an endoscopic Mayo score of 0 or 1. Clinical relapse was defined as the need for therapy to induce remission, any treatment escalation, hospitalization or colectomy. All clinical relapses were evaluated at months 6 and 12 after study entry. Results were subjected to unconditional stepwise logistic and Kaplan-Meier regression analysis. One hundred and eighty-seven consecutive UC patients (126 [67.3%] with Mayo score 0 and 61 [32.7%] with Mayo score 1) were included. Of patients with Mayo scores 0 and 1, 9.4 and 36.6% respectively presented a relapse during the first 6 months of follow-up (p < 0.001). The only factor independently associated with UC relapses in the multivariate analysis was an endoscopic Mayo score of 1 (odds ratio 6.27, 95% confidence interval 2.73-14.40, p < 0.001). Patients with an endoscopic Mayo score of 1 have a higher risk of relapse than those with a score of 0. The concept of mucosal healing should be limited to patients with an endoscopic Mayo score of 0. Copyright © 2015 European Crohn’s and Colitis Organisation (ECCO). Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oup.com.

  9. The positional relationship between facial nerve and round window niche in patients with congenital aural atresia and stenosis.

    PubMed

    Chen, Keguang; Lyu, Huiying; Xie, Youzhou; Yang, Lin; Zhang, Tianyu; Dai, Peidong

    2016-03-01

    To investigate whether differences existing in the distance between facial nerve (FN) and round window niche opening among congenital aural atresia (CAA), congenital aural stenosis (CAS) and a normal control group and to assess its effect on the round window implantation of vibrant soundbridge, CT images of 10 normal subjects (20 ears), 27 CAS patients (30 ears) and 25 CAA patients (30 ears) were analyzed. The distances from the central point of round window niche opening to the terminal point of the horizontal segment, the salient point of pyramidal segment, the beginning point of the vertical segment, and the vertical segment of the facial nerve (abbreviate as OA, OB, OC, OE, respectively) were calculated based on three-dimensional reconstruction using mimics software. The results suggested that the pyramidal segment of the FN was positioned more closely to round window niche opening in patients with both CAA and CAS groups than that in control group, whereas there was no significant difference between CAA and CAS group (P < 0.05). The vertical portion of the FN was positioned more closely to round window niche opening in the CAA group than those in both the CAS and control groups with statistical significance (P < 0.05). Furthermore, the vertical portion of the FN was positioned more closely to round window niche opening in the CAS group than that in control group (P < 0.05). In conclusion, the dislocation between facial nerve and round window niche in patients with congenital auditory canal malformations could have significant effects on the round window implantation of vibrant soundbridge. Moreover, three-dimensional measurements and assessments before surgery might be helpful for a safer surgical approach and implantation of vibrant soundbridge.

  10. [Discussion on relationship between "living alone with closed windows and doors" and depression].

    PubMed

    Liu, Fengfeng; Li, Rui

    2018-03-12

    "Living alone with closed windows and doors"was mentioned in the pathological manifestations of stomach meridian of foot- yangming in Neijing ( The Inner Canon of Huangdi ), which is similar to the symptoms of depression. Currently the treatment of depression is mostly based on"spirit being stored in five organs"theory, and little attention is paid on stomach meridian of foot- yangming . From the pathological manifestations of"living alone with closed windows and doors"in stomach meridian of foot- yangming , the relationship between stomach meridian and depression is discussed from ying-yang and qi -blood. In addition, the close relationship between the stomach meridian and qi -blood, qi movement of five organs, heart and brain is discussed to explore the mechanism of treating depression. In conclusion, the literature and modern research regarding treating depression from stomach meridian are summarized, hoping to provide more clinical methods for the treatment of depression.

  11. Hospitalists working with orthopedic surgeons is a hot idea at Mayo Clinic.

    PubMed

    2004-10-01

    Even at the renowned Mayo Clinic, a performance improvement that results in patients having fewer complications and shorter lengths of stay is considered a hot idea. The Mayo Clinic's Hospitalist-Orthopedic Team (HOT) program has lived up to its name.

  12. The Mayo brothers: an American surgical legacy.

    PubMed

    Toledo-Pereyra, Luis H

    2010-10-01

    Few in the history of surgery and just as few in the history of medicine can reach the level of clinical visibility as achieved by the Mayo brothers. The brothers changed the face of medicine while they were alive, and their fame and influence continued to grow after their death in 1939. The Mayo American surgical legacy had incredible proportions. The brothers systematically modified the field as few others had done before. They were great surgical innovators who took the surgical techniques of others and added a touch of their own to make the surgical procedure better and more secure. The Mayos were the stars regionally, nationally, and around the world. They attracted attention from their generation and occupied center stage long after. To speak of the Mayos is to speak of the quintessential American values of professionalism, respect, commitment, and caring for their fellow human beings. Their creation, the Mayo Clinic, surpassed the wildest hopes and predictions that anyone could have had regarding their best dreams.

  13. Decreasing Patient Stress and Physician/Medical Workforce Burnout Through Health Care Environments: Uncovering the Serious Leisure Perspective at Mayo Clinic's Campus in Rochester, Minnesota.

    PubMed

    Dieser, Rodney B; Edginton, Christopher R; Ziemer, Renee

    2017-07-01

    Health care environments are places of high stress for both patients and medical professionals. Although organizational efforts of workload and efficiency are often implemented to decrease both patient and physician/medical workforce stress, what is often overlooked is how leisure opportunities and programs located in day-to-day experiences and in physically built environments can increase both patient and medical staff enjoyment and pleasure, thus lowering patient stress and physician/medical staff burnout. Combining historical research on the leisure pursuits of Drs William J. Mayo and Charles H. Mayo, literature on leisure, stress, and burnout, and a case study methodology of Mayo Clinic's campus in Rochester, Minnesota, the purpose of this study was to describe how the Serious Leisure Perspective (SLP) exists at Mayo Clinic and contributes to relieving stress among patients and preventing burnout among physicians. Copyright © 2017 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc. All rights reserved.

  14. Particle penetration into the automotive interior. I. Influence of vehicle speed and ventilatory mode.

    PubMed

    Muilenberg, M L; Skellenger, W S; Burge, H A; Solomon, W R

    1991-02-01

    Penetration of particulate aeroallergens into the interiors of two, new, similar Chrysler Corporation passenger vehicles (having no evidence of intrinsic microbial contamination) was studied on a large circular test track during periods of high pollen and spore prevalence. Impactor collections were obtained at front and rear seat points and at the track center during periods with (1) windows and vents closed and air conditioning on, (2) windows closed, vents open, and no air conditioning, and (3) air conditioner off, front windows open, and vents closed. These conditions were examined sequentially during travel at 40, 50, 60, and 80 kph. Particle recoveries within the two, new, similar Chrysler Corporation passenger vehicles did not vary with the speed of travel, either overall or with regard to each of the three ventilatory modalities. In addition, collections at front and rear seat sampling points were comparable. Highest interior aeroallergen levels were recorded with WO, and yet, these levels averaged only half the concurrent outside concentrations at track center. Recoveries within the cars were well below recoveries obtained outside when windows were closed (both VO and AC modes). These findings suggest window ventilation as an overriding factor determining particle ingress into moving vehicles. Efforts to delineate additional determinants of exposure by direct sampling are feasible and would appear essential in formulating realistic strategies of avoidance.

  15. The Visiting Medical Student Clerkship Program at Mayo Clinic

    PubMed Central

    Mueller, Paul S.; McConahey, Linda L.; Orvidas, Laura J.; Jenkins, Sarah M.; Kasten, Mary J.

    2010-01-01

    OBJECTIVE: To describe the history, objectives, statistics, and initiatives used to address challenges associated with the Mayo Clinic Visiting Medical Student (VMS) Clerkship Program. MATERIALS AND METHODS: Mayo Clinic administrative records were reviewed for calendar years 1995 through 2008 to determine the effect of interventions to increase the numbers of appropriately qualified international VMSs and underrepresented minority VMSs. For numerical data, descriptive statistics were used; for comparisons, χ2 tests were performed. RESULTS: During the specified period, 4908 VMSs participated in the Mayo VMS Program (yearly mean [SD], 351 [24]). Most students were from US medical schools (3247 [66%]) and were male (3084 [63%]). Overall, 3101 VMSs (63%) applied for and 935 (30%) were appointed to Mayo Clinic residency program positions. Interventions to address the challenge of large numbers of international students who participated in our VMS program but did not apply for Mayo residency positions resulted in significantly fewer international students participating in our VMS program (P<.001), applying for Mayo residency program positions (P<.001), and being appointed to residency positions (P=.001). Interventions to address the challenge of low numbers of underrepresented minority students resulted in significantly more of these students participating in our VMS program (P=.005), applying for Mayo residency positions (P=.008), and being appointed to residency positions (P=.04). CONCLUSION: Our findings suggest that specific interventions can affect the characteristics of students who participate in VMS programs and who apply for and are appointed to residency program positions. PMID:20675510

  16. The visiting medical student clerkship program at Mayo Clinic.

    PubMed

    Mueller, Paul S; McConahey, Linda L; Orvidas, Laura J; Jenkins, Sarah M; Kasten, Mary J

    2010-08-01

    To describe the history, objectives, statistics, and initiatives used to address challenges associated with the Mayo Clinic Visiting Medical Student (VMS) Clerkship Program. Mayo Clinic administrative records were reviewed for calendar years 1995 through 2008 to determine the effect of interventions to increase the numbers of appropriately qualified international VMSs and underrepresented minority VMSs. For numerical data, descriptive statistics were used; for comparisons, chi(2) tests were performed. During the specified period, 4908 VMSs participated in the Mayo VMS Program (yearly mean [SD], 351 [24]). Most students were from US medical schools (3247 [66%]) and were male (3084 [63%]). Overall, 3101 VMSs (63%) applied for and 935 (30%) were appointed to Mayo Clinic residency program positions. Interventions to address the challenge of large numbers of international students who participated in our VMS program but did not apply for Mayo residency positions resulted in significantly fewer international students participating in our VMS program (P<.001), applying for Mayo residency program positions (P<.001), and being appointed to residency positions (P=.001). Interventions to address the challenge of low numbers of underrepresented minority students resulted in significantly more of these students participating in our VMS program (P=.005), applying for Mayo residency positions (P=.008), and being appointed to residency positions (P=.04). Our findings suggest that specific interventions can affect the characteristics of students who participate in VMS programs and who apply for and are appointed to residency program positions.

  17. Twenty years of human immunodeficiency virus care at the Mayo Clinic: Past, present and future.

    PubMed

    Cummins, Nathan W; Badley, Andrew D; Kasten, Mary J; Sampath, Rahul; Temesgen, Zelalem; Whitaker, Jennifer A; Wilson, John W; Yao, Joseph D; Zeuli, John; Rizza, Stacey A

    2016-05-12

    The Mayo human immunodeficiency virus (HIV) Clinic has been providing patient centered care for persons living with HIV in Minnesota and beyond for the past 20 years. Through multidisciplinary engagement, vital clinical outcomes such as retention in care, initiation of antiretroviral therapy and virologic suppression are maximized. In this commentary, we describe the history of the Mayo HIV Clinic and its best practices, providing a "Mayo Model" of HIV care that exceeds national outcomes and may be applicable in other settings.

  18. Twenty years of human immunodeficiency virus care at the Mayo Clinic: Past, present and future

    PubMed Central

    Cummins, Nathan W; Badley, Andrew D; Kasten, Mary J; Sampath, Rahul; Temesgen, Zelalem; Whitaker, Jennifer A; Wilson, John W; Yao, Joseph D; Zeuli, John; Rizza, Stacey A

    2016-01-01

    The Mayo human immunodeficiency virus (HIV) Clinic has been providing patient centered care for persons living with HIV in Minnesota and beyond for the past 20 years. Through multidisciplinary engagement, vital clinical outcomes such as retention in care, initiation of antiretroviral therapy and virologic suppression are maximized. In this commentary, we describe the history of the Mayo HIV Clinic and its best practices, providing a “Mayo Model” of HIV care that exceeds national outcomes and may be applicable in other settings. PMID:27175350

  19. Mayo Clinic Care Network: A Collaborative Health Care Model.

    PubMed

    Wald, John T; Lowery-Schrandt, Sherri; Hayes, David L; Kotsenas, Amy L

    2018-01-01

    By leveraging its experience and expertise as a consultative clinical partner, the Mayo Clinic developed an innovative, scalable care model to accomplish several strategic goals: (1) create and sustain high-value relationships that benefit patients and providers, (2) foster relationships with like-minded partners to act as a strategy against the development of narrow health care networks, and (3) increase national and international brand awareness of Mayo Clinic. The result was the Mayo Clinic Care Network. Copyright © 2017 American College of Radiology. Published by Elsevier Inc. All rights reserved.

  20. 47 CFR 73.871 - Amendment of LPFM broadcast station applications.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... limitation during the pertinent filing window. (b) Amendments that would improve the comparative position of new and major change applications will not be accepted after the close of the pertinent filing window... the pertinent filing window. Subject to the provisions of this section, such amendments may be filed...

  1. Shelter

    MedlinePlus

    ... room on the lowest level away from corners, windows, doors and outside walls. The safest locations to ... your family and pets inside. Lock doors, close windows, air vents and fireplace dampers. Turn off fans, ...

  2. The Mayo Innovation Scholars Program: Undergraduates Explore the Science and Economics of Medical Innovations

    ERIC Educational Resources Information Center

    Pellegrini, John J.; Jansen, Elizabeth

    2013-01-01

    The Mayo Innovation Scholars Program introduces undergraduates to technology transfer in biomedical sciences by having teams of students from multiple disciplines (e.g., biology, chemistry, economics, and business) analyze inventions in development at the Mayo Clinic. Over 6 months, teams consult with inventors, intellectual property experts, and…

  3. The effect of screening doors and windows on indoor density of Anopheles arabiensis in south-west Ethiopia: a randomized trial

    PubMed Central

    2013-01-01

    Background Screening of houses might have impact on density of indoor host-seeking Anopheles mosquitoes. A randomized trial of screening windows and doors with metal mesh, and closing openings on eves and walls by mud was conducted to assess if reduce indoor densities of biting mosquitoes. Methods Mosquitoes were collected in forty houses using Centers for Diseases Control and Prevention (CDC) light traps biweekly in March and April 2011. A randomization of houses into control and intervention groups was done based on the baseline data. Windows and doors of 20 houses were screened by metal mesh, and openings on the walls and eves closed by mud and the rest 20 houses were used as control group. Mosquitoes were collected biweekly in October and November 2011 from both control and intervention houses. A Generalized Estimating Equations (GEE) with a negative binomial error distribution was used to account for over dispersion of Anopheles arabiensis and culicine counts and repeated catches made in the same house. Results Screening doors and windows, and closing openings on eves and wall by mud reduced the overall indoor densities of An. arabiensis by 40%. The effect of screenings pronounced on unfed An. arabiensis by resulting 42% reduction in houses with interventions. The total costs for screening windows and doors, and to close openings on the eves and walls by mud was 7.34 USD per house. Conclusion Screening houses reduced indoor density of An. arabiensis, and it was cheap and can easily incorporated into malaria vector strategies by local communities, but improving doors and windows fitness for screening should be considered during house construction to increase the efficacy of screenings. PMID:24028542

  4. The effect of screening doors and windows on indoor density of Anopheles arabiensis in south-west Ethiopia: a randomized trial.

    PubMed

    Massebo, Fekadu; Lindtjørn, Bernt

    2013-09-12

    Screening of houses might have impact on density of indoor host-seeking Anopheles mosquitoes. A randomized trial of screening windows and doors with metal mesh, and closing openings on eves and walls by mud was conducted to assess if reduce indoor densities of biting mosquitoes. Mosquitoes were collected in forty houses using Centers for Diseases Control and Prevention (CDC) light traps biweekly in March and April 2011. A randomization of houses into control and intervention groups was done based on the baseline data. Windows and doors of 20 houses were screened by metal mesh, and openings on the walls and eves closed by mud and the rest 20 houses were used as control group. Mosquitoes were collected biweekly in October and November 2011 from both control and intervention houses. A Generalized Estimating Equations (GEE) with a negative binomial error distribution was used to account for over dispersion of Anopheles arabiensis and culicine counts and repeated catches made in the same house. Screening doors and windows, and closing openings on eves and wall by mud reduced the overall indoor densities of An. arabiensis by 40%. The effect of screenings pronounced on unfed An. arabiensis by resulting 42% reduction in houses with interventions. The total costs for screening windows and doors, and to close openings on the eves and walls by mud was 7.34 USD per house. Screening houses reduced indoor density of An. arabiensis, and it was cheap and can easily incorporated into malaria vector strategies by local communities, but improving doors and windows fitness for screening should be considered during house construction to increase the efficacy of screenings.

  5. Templated fabrication of hollow nanospheres with 'windows' of accurate size and tunable number.

    PubMed

    Xie, Duan; Hou, Yidong; Su, Yarong; Gao, Fuhua; Du, Jinglei

    2015-01-01

    The 'windows' or 'doors' on the surface of a closed hollow structure can enable the exchange of material and information between the interior and exterior of one hollow sphere or between two hollow spheres, and this information or material exchange can also be controlled through altering the window' size. Thus, it is very interesting and important to achieve the fabrication and adjustment of the 'windows' or 'doors' on the surface of a closed hollow structure. In this paper, we propose a new method based on the temple-assisted deposition method to achieve the fabrication of hollow spheres with windows of accurate size and number. Through precisely controlling of deposition parameters (i.e., deposition angle and number), hollow spheres with windows of total size from 0% to 50% and number from 1 to 6 have been successfully achieved. A geometrical model has been developed for the morphology simulation and size calculation of the windows, and the simulation results meet well with the experiment. This model will greatly improve the convenience and efficiency of this temple-assisted deposition method. In addition, these hollow spheres with desired windows also can be dispersed into liquid or arranged regularly on any desired substrate. These advantages will maximize their applications in many fields, such as drug transport and nano-research container.

  6. Air change rates of motor vehicles and in-vehicle pollutant concentrations from secondhand smoke.

    PubMed

    Ott, Wayne; Klepeis, Neil; Switzer, Paul

    2008-05-01

    The air change rates of motor vehicles are relevant to the sheltering effect from air pollutants entering from outside a vehicle and also to the interior concentrations from any sources inside its passenger compartment. We made more than 100 air change rate measurements on four motor vehicles under moving and stationary conditions; we also measured the carbon monoxide (CO) and fine particle (PM(2.5)) decay rates from 14 cigarettes smoked inside the vehicle. With the vehicle stationary and the fan off, the ventilation rate in air changes per hour (ACH) was less than 1 h(-1) with the windows closed and increased to 6.5 h(-1) with one window fully opened. The vehicle speed, window position, ventilation system, and air conditioner setting was found to affect the ACH. For closed windows and passive ventilation (fan off and no recirculation), the ACH was linearly related to the vehicle speed over the range from 15 to 72 mph (25 to 116 km h(-1)). With a vehicle moving, windows closed, and the ventilation system off (or the air conditioner set to AC Max), the ACH was less than 6.6 h(-1) for speeds ranging from 20 to 72 mph (32 to 116 km h(-1)). Opening a single window by 3'' (7.6 cm) increased the ACH by 8-16 times. For the 14 cigarettes smoked in vehicles, the deposition rate k and the air change rate a were correlated, following the equation k=1.3a (R(2)=82%; n=14). With recirculation on (or AC Max) and closed windows, the interior PM(2.5) concentration exceeded 2000 microg m(-3) momentarily for all cigarettes tested, regardless of speed. The concentration time series measured inside the vehicle followed the mathematical solutions of the indoor mass balance model, and the 24-h average personal exposure to PM(2.5) could exceed 35 microg m(-3) for just two cigarettes smoked inside the vehicle.

  7. 49 CFR 571.118 - Standard No. 118; Power-operated window, partition, and roof panel systems.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...-operated window, partition, and roof panel systems. S1. Purpose and scope. This standard specifies requirements for power operated window, partition, and roof panel systems to minimize the likelihood of death... Figure 2. Power operated roof panel systems mean moveable panels in the vehicle roof which close by...

  8. 49 CFR 571.118 - Standard No. 118; Power-operated window, partition, and roof panel systems.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...-operated window, partition, and roof panel systems. S1. Purpose and scope. This standard specifies requirements for power operated window, partition, and roof panel systems to minimize the likelihood of death... Figure 2. Power operated roof panel systems mean moveable panels in the vehicle roof which close by...

  9. 49 CFR 571.118 - Standard No. 118; Power-operated window, partition, and roof panel systems.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...-operated window, partition, and roof panel systems. S1. Purpose and scope. This standard specifies requirements for power operated window, partition, and roof panel systems to minimize the likelihood of death... Figure 2. Power operated roof panel systems mean moveable panels in the vehicle roof which close by...

  10. 49 CFR 571.118 - Standard No. 118; Power-operated window, partition, and roof panel systems.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...-operated window, partition, and roof panel systems. S1. Purpose and scope. This standard specifies requirements for power operated window, partition, and roof panel systems to minimize the likelihood of death... Figure 2. Power operated roof panel systems mean moveable panels in the vehicle roof which close by...

  11. 49 CFR 571.118 - Standard No. 118; Power-operated window, partition, and roof panel systems.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...-operated window, partition, and roof panel systems. S1. Purpose and scope. This standard specifies requirements for power operated window, partition, and roof panel systems to minimize the likelihood of death... Figure 2. Power operated roof panel systems mean moveable panels in the vehicle roof which close by...

  12. Comparing on-road real-time simultaneous in-cabin and outdoor particulate and gaseous concentrations for a range of ventilation scenarios

    NASA Astrophysics Data System (ADS)

    Leavey, Anna; Reed, Nathan; Patel, Sameer; Bradley, Kevin; Kulkarni, Pramod; Biswas, Pratim

    2017-10-01

    Advanced automobile technology, developed infrastructure, and changing economic markets have resulted in increasing commute times. Traffic is a major source of harmful pollutants and consequently daily peak exposures tend to occur near roadways or while travelling on them. The objective of this study was to measure simultaneous real-time particulate matter (particle numbers, lung-deposited surface area, PM2.5, particle number size distributions) and CO concentrations outside and in-cabin of an on-road car during regular commutes to and from work. Data was collected for different ventilation parameters (windows open or closed, fan on, AC on), whilst travelling along different road-types with varying traffic densities. Multiple predictor variables were examined using linear mixed-effects models. Ambient pollutants (NOx, PM2.5, CO) and meteorological variables (wind speed, temperature, relative humidity, dew point) explained 5-44% of outdoor pollutant variability, while the time spent travelling behind a bus was statistically significant for PM2.5, lung-deposited SA, and CO (adj-R2 values = 0.12, 0.10, 0.13). The geometric mean diameter (GMD) for outdoor aerosol was 34 nm. Larger cabin GMDs were observed when windows were closed compared to open (b = 4.3, p-value = <0.01). When windows were open, cabin total aerosol concentrations tracked those outdoors. With windows closed, the pollutants took longer to enter the vehicle cabin, but also longer to exit it. Concentrations of pollutants in cabin were influenced by outdoor concentrations, ambient temperature, and the window/ventilation parameters. As expected, particle number concentrations were impacted the most by changes to window position/ventilation, and PM2.5 the least. Car drivers can expect their highest exposures when driving with windows open or the fan on, and their lowest exposures during windows closed or the AC on. Final linear mixed-effects models could explain between 88 and 97% of cabin pollutant concentration variability. An individual may control their commuting exposure by applying dynamic behavior modification to adapt to changing pollutant scenarios.

  13. Comparing on-road real-time simultaneous in-cabin and outdoor particulate and gaseous concentrations for a range of ventilation scenarios

    PubMed Central

    Leavey, Anna; Reed, Nathan; Patel, Sameer; Bradley, Kevin; Kulkarni, Pramod; Biswas, Pratim

    2017-01-01

    Advanced automobile technology, developed infrastructure, and changing economic markets have resulted in increasing commute times. Traffic is a major source of harmful pollutants and consequently daily peak exposures tend to occur near roadways or while traveling on them. The objective of this study was to measure simultaneous real-time particulate matter (particle numbers, lung-deposited surface area, PM2.5, particle number size distributions) and CO concentrations outside and in-cabin of an on-road car during regular commutes to and from work. Data was collected for different ventilation parameters (windows open or closed, fan on, AC on), whilst traveling along different road-types with varying traffic densities. Multiple predictor variables were examined using linear mixed-effects models. Ambient pollutants (NOx, PM2.5, CO) and meteorological variables (wind speed, temperature, relative humidity, dew point) explained 5–44% of outdoor pollutant variability, while the time spent travelling behind a bus was statistically significant for PM2.5, lung-deposited SA, and CO (adj-R2 values = 0.12, 0.10, 0.13). The geometric mean diameter (GMD) for outdoor aerosol was 34 nm. Larger cabin GMDs were observed when windows were closed compared to open (b = 4.3, p-value = <0.01). When windows were open, cabin total aerosol concentrations tracked those outdoors. With windows closed, the pollutants took longer to enter the vehicle cabin, but also longer to exit it. Concentrations of pollutants in cabin were influenced by outdoor concentrations, ambient temperature, and the window/ventilation parameters. As expected, particle number concentrations were impacted the most by changes to window position / ventilation, and PM2.5 the least. Car drivers can expect their highest exposures when driving with windows open or the fan on, and their lowest exposures during windows closed or the AC on. Final linear mixed-effects models could explain between 88–97% of cabin pollutant concentration variability. An individual may control their commuting exposure by applying dynamic behavior modification to adapt to changing pollutant scenarios. PMID:29284988

  14. Comparing on-road real-time simultaneous in-cabin and outdoor particulate and gaseous concentrations for a range of ventilation scenarios.

    PubMed

    Leavey, Anna; Reed, Nathan; Patel, Sameer; Bradley, Kevin; Kulkarni, Pramod; Biswas, Pratim

    2017-10-01

    Advanced automobile technology, developed infrastructure, and changing economic markets have resulted in increasing commute times. Traffic is a major source of harmful pollutants and consequently daily peak exposures tend to occur near roadways or while traveling on them. The objective of this study was to measure simultaneous real-time particulate matter (particle numbers, lung-deposited surface area, PM 2.5 , particle number size distributions) and CO concentrations outside and in-cabin of an on-road car during regular commutes to and from work. Data was collected for different ventilation parameters (windows open or closed, fan on, AC on), whilst traveling along different road-types with varying traffic densities. Multiple predictor variables were examined using linear mixed-effects models. Ambient pollutants (NO x , PM 2.5 , CO) and meteorological variables (wind speed, temperature, relative humidity, dew point) explained 5-44% of outdoor pollutant variability, while the time spent travelling behind a bus was statistically significant for PM 2.5, lung-deposited SA, and CO (adj-R 2 values = 0.12, 0.10, 0.13). The geometric mean diameter (GMD) for outdoor aerosol was 34 nm. Larger cabin GMDs were observed when windows were closed compared to open (b = 4.3, p-value = <0.01). When windows were open, cabin total aerosol concentrations tracked those outdoors. With windows closed, the pollutants took longer to enter the vehicle cabin, but also longer to exit it. Concentrations of pollutants in cabin were influenced by outdoor concentrations, ambient temperature, and the window/ventilation parameters. As expected, particle number concentrations were impacted the most by changes to window position / ventilation, and PM 2.5 the least. Car drivers can expect their highest exposures when driving with windows open or the fan on, and their lowest exposures during windows closed or the AC on. Final linear mixed-effects models could explain between 88-97% of cabin pollutant concentration variability. An individual may control their commuting exposure by applying dynamic behavior modification to adapt to changing pollutant scenarios.

  15. 76 FR 23322 - Change in Bank Control Notices; Acquisitions of Shares of a Bank or Bank Holding Company

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-26

    ... Street, Dallas, Texas 75201-2272: 1. Jonathan Ross Kasling of Hughes Springs, Texas, Individually; Mayo Givens Kasling III of Hughes Springs, Texas, Individually; Jonathan Ross Kasling of Hughes Springs, Texas; Mayo Givens Kasling III of Hughes Springs, Texas; Mayo Givens Kasling, Jr. of Hughes Springs, Texas and...

  16. The noise environment of a school classroom due to the operation of utility helicopters. [acoustic measurements of helicopter noise during flight over building

    NASA Technical Reports Server (NTRS)

    Hilton, D. A.; Pegg, R. J.

    1974-01-01

    Noise measurements under controlled conditions have been made inside and outside of a school building during flyover operations of four different helicopters. The helicopters were operated at a condition considered typical for a police patrol mission. Flyovers were made at an altitude of 500 ft and an airspeed of 45 miles per hour. During these operations acoustic measurements were made inside and outside of the school building with the windows closed and then open. The outside noise measurements during helicopter flyovers indicate that the outside db(A) levels were approximately the same for all test helicopters. For the windows closed case, significant reductions for the inside measured db(A) values were noted for all overflights. These reductions were approximately 20 db(A); similar reductions were noted in other subjective measuring units. The measured internal db(A) levels with the windows open exceeded published classroom noise criteria values; however, for the windows-closed case they are in general agreement with the criteria values.

  17. Optimal Window and Lattice in Gabor Transform. Application to Audio Analysis.

    PubMed

    Lachambre, Helene; Ricaud, Benjamin; Stempfel, Guillaume; Torrésani, Bruno; Wiesmeyr, Christoph; Onchis-Moaca, Darian

    2015-01-01

    This article deals with the use of optimal lattice and optimal window in Discrete Gabor Transform computation. In the case of a generalized Gaussian window, extending earlier contributions, we introduce an additional local window adaptation technique for non-stationary signals. We illustrate our approach and the earlier one by addressing three time-frequency analysis problems to show the improvements achieved by the use of optimal lattice and window: close frequencies distinction, frequency estimation and SNR estimation. The results are presented, when possible, with real world audio signals.

  18. Against the Corporate Culture Ideology: An Interview with Peter Mayo

    ERIC Educational Resources Information Center

    Suoranta, Juha

    2010-01-01

    This article presents an interview with Peter Mayo, author and expert in the field of sociology of adult education, on his major influences in this area, his books, and his views on the role of radical adult education and radical scholarship in the future. In the interview, Peter Mayo states that his initial view of adult education was quite a…

  19. International market research at the Mayo Clinic.

    PubMed

    Hathaway, M; Seltman, K

    2001-01-01

    Mayo Clinic has a long international history and has been providing care to international patients since its inception. Despite its history and reputation, however, the marketing staff continues to monitor the international market to gauge the level of awareness, reputation, and attractiveness of Mayo Clinic around the world. Here's a look at how one institution has used word-of-mouth marketing to maintain its global reputation.

  20. Field and laboratory studies of moving and temporally variable noise sources (aircraft); perception of location, movement, and direction.

    PubMed

    Gunn, W J; Shigehisa, T; Shepherd, W T

    1979-10-01

    The conditions were examined under which more valid and reliable estimates could be made of the effects of aircraft noise on people. In Exper. 1, 12 Ss in 2 different houses directly under the flight path of a major airport (JFK) indicated 1 of 12 possible flight paths (4 directly overhead and 8 to one side) for each of 3 jet aircraft flyovers: 3% of cases in House A and 56% in House B (which had open windows) were correctly identified. Despite judgment inaccuracy, Ss were more than moderately certain of the correctness of their judgments. In Exper. II. Ss either inside or outside of 2 houses in Wallops Station, Virginia, indicated on diagrams the direction of flyovers. Each of 4 aircraft (Boeing 737, C-54, UE-1 helicopter, Queenaire) made 8 flyovers directly over the houses and 8 to one side. Windows were either open or closed. All flyovers and conditions were counterbalanced. All sound sources under all conditions were usually judged to be overhead and moving, but for Ss indoors with windows closed the to-the-side flyovers were judged to be off to the side in 24% of cases. Outdoor Ss reported correct direction in 75% of cases while indoor Ss were correct in only 25% (windows open) or 18% (windows closed). Judgments "to the side" were significantly better (p = less than .02) with windows open vs closed, while with windows closed judgments were significantly better (p = less than .05) for flyovers overhead vs to the side. In Exper. III, Ss localized in azimuth and in the vertical plane recorded noises (10 1-oct noise bands of CF = 28.12 c/s - 14.4kc/s, spoken voice, and jet aircraft takeoffs and landings), presented through 1, 2, or 4 floor-level loudspeakers at each corner of a simulated living room (4.2 x 5.4m)built inside an IAC soundproof room. Aircraft noises presented by 4 loudspeakers were localized as "directly" overhead 80% of the time and "generally overhead" about 90% of the time; other sounds were so localized about 50% and 75% of the time respectively. Through only 2 loudspeakers, aircraft noises were localized 25-36 degrees above horizontal. Implications are that acoustic realism can be achieved in simulated aircraft overflights and that future laboratory noise-effects research should incorporate the required conditions.

  1. The Impact of Changing Cloud Cover on the High Arctic's Primary Cooling-to-space Windows

    NASA Astrophysics Data System (ADS)

    Mariani, Zen; Rowe, Penny; Strong, Kimberly; Walden, Von; Drummond, James

    2014-05-01

    In the Arctic, most of the infrared energy emitted by the surface escapes to space in two atmospheric windows at 10 and 20 μm. As the Arctic warms, the 20 μm cooling-to-space window becomes increasingly opaque (or "closed"), trapping more surface infrared radiation in the atmosphere, with implications for the Arctic's radiative energy balance. Since 2006, the Canadian Network for the Detection of Atmospheric Change (CANDAC) has measured downwelling infrared radiance with an Atmospheric Emitted Radiance Interferometer (AERI) at the Polar Environment Atmospheric Research Laboratory (PEARL) at Eureka, Canada, providing the first long-term measurements of the 10 and 20 μm windows in the high Arctic. In this work, measurements of the distribution of downwelling 10 and 20 µm brightness temperatures at Eureka are separated based on cloud cover, providing a comparison to an existing climatology from the Southern Great Plains (SGP). Measurements of the downwelling radiance at both 10 and 20 μm exhibit strong seasonal variability as a result of changes in temperature and water vapour, in addition to variability with cloud cover. When separated by season, brightness temperatures in the 20 µm window are found to be independent of cloud thickness in the summertime, indicating that this window is closed in the summer. Radiance trends in three-month averages are positive and are significantly larger (factor > 5) than the trends detected at the SGP, indicating that changes in the downwelling radiance are accelerated in the high Arctic compared to lower latitudes. This statistically significant increase (> 5% / yr) in radiance at 10 μm occurs only when the 20 μm window is mostly transparent, or "open" (i.e., in all seasons except summer), and may have long-term consequences, particularly as warmer temperatures and increased water vapour "close" the dirty window for a prolonged period. These surface-based measurements of radiative forcing can be used to quantify changes in the high-Arctic energy budget and evaluate general circulation model simulations.

  2. What makes a Catholic hospital "Catholic" in an age of religious-secular collaboration? The case of the Saint Marys hospital and the Mayo Clinic.

    PubMed

    Swetz, Keith M; Crowley, Mary E; Maines, T Dean

    2013-06-01

    Mayo Clinic is recognized as a worldwide leader in innovative, high-quality health care. However, the Catholic mission and ideals from which this organization was formed are not widely recognized or known. From partnership with the Sisters of St. Francis in 1883, through restructuring of the Sponsorship Agreement in 1986 and current advancements, this Catholic mission remains vital today at Saint Marys Hospital. This manuscript explores the evolution and growth of sponsorship at Mayo Clinic, defined as "a collaboration between the Sisters of St. Francis and Mayo Clinic to preserve and promote key values that the founding Franciscan sisters and Mayo physicians embrace as basic to their mission, and to assure the Catholic identity of Saint Marys Hospital." Historical context will be used to frame the evolution and preservation of Catholic identity at Saint Marys Hospital; and the shift from a "sponsorship-by-governance" to a "sponsorship-by-influence" model will be highlighted. Lastly, using the externally-developed Catholic Identity Matrix (developed by Ascension Health and the University of St. Thomas, Minnesota), specific examples of Catholic identity will be explored in this joint venture of Catholic health care institution and a secular, nonprofit corporation (Mayo Clinic).

  3. The Pine Ridge-Mayo National Aeronautics and Space Administration telemedicine project: program activities and participant reactions.

    PubMed

    Kottke, T E; Little Finger, L; Trapp, M A; Panser, L A; Novotny, P J

    1996-04-01

    To determine the response of participants to the Pine Ridge-Mayo National Aeronautics and Space Administration telemedicine project. We describe a 3-month demonstration project of medical education and clinical consultations conducted by means of satellite transmission. Postparticipation questionnaires and a postproject survey were used to assess the success of the activity. Patients and employees at the Pine Ridge Indian Health Service Hospital in southwestern South Dakota and employees at Mayo Clinic Rochester participated in a telemedicine project, after which they completed exit surveys and a postproject questionnaire to ascertain the acceptability of this mode of health care. Almost all Pine Ridge and Mayo Clinic participants viewed the project as beneficial. The educational sessions received favorable evaluations, and almost two-thirds of the patients who completed evaluations thought the consultation had contributed to their medical care. More than 90% of the respondents from Pine Ridge and more than 85% of the respondents from Mayo Clinic Rochester said that they would recommend participation in this project to others. More than 90% of respondents from Pine Ridge and 80% of Mayo respondents agreed with the statement that the project should continue. These data suggest that a program of clinical consultation services, professional education, and patient education available by telemedicine might be viewed as beneficial.

  4. SECOND FLOOR FRONT ROOM, WINDOWS FACING ON WALNUT STREET (SOUTH), ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    SECOND FLOOR FRONT ROOM, WINDOWS FACING ON WALNUT STREET (SOUTH), ORIGINAL PANELED FOLDING SHUTTERS AND HARDWARE. For a view of closed shutters see PA-1436 A-16 - Kid-Chandler House, 323 Walnut Street, Philadelphia, Philadelphia County, PA

  5. 14. CLOSEUP VIEW OF WINDOW IN SIGNAL TOWER OFFICE FACING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    14. CLOSE-UP VIEW OF WINDOW IN SIGNAL TOWER OFFICE FACING WEST. - U.S. Naval Base, Pearl Harbor, Signal Tower, Corner of Seventh Street & Avenue D east of Drydock No. 1, Pearl City, Honolulu County, HI

  6. Diversion of drugs within health care facilities, a multiple-victim crime: patterns of diversion, scope, consequences, detection, and prevention.

    PubMed

    Berge, Keith H; Dillon, Kevin R; Sikkink, Karen M; Taylor, Timothy K; Lanier, William L

    2012-07-01

    Mayo Clinic has been involved in an ongoing effort to prevent the diversion of controlled substances from the workplace and to rapidly identify and respond when such diversion is detected. These efforts have found that diversion of controlled substances is not uncommon and can result in substantial risk not only to the individual who is diverting the drugs but also to patients, co-workers, and employers. We believe that all health care facilities should have systems in place to deter controlled substance diversion and to promptly identify diversion and intervene when it is occurring. Such systems are multifaceted and require close cooperation between multiple stakeholders including, but not limited to, departments of pharmacy, safety and security, anesthesiology, nursing, legal counsel, and human resources. Ideally, there should be a broad-based appreciation of the dangers that diversion creates not only for patients but also for all employees of health care facilities, because diversion can occur at any point along a long supply chain. All health care workers must be vigilant for signs of possible diversion and must be aware of how to engage a preexisting group with expertise in investigating possible diversions. In addition, clear policies and procedures should be in place for dealing with such investigations and for managing the many possible outcomes of a confirmed diversion. This article provides an overview of the multiple types of risk that result from drug diversion from health care facilities. Further, we describe a system developed at Mayo Clinic for evaluating episodes of potential drug diversion and for taking action once diversion is confirmed. Copyright © 2012 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc. All rights reserved.

  7. Milia

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  8. Epiglottitis

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  9. Orchitis

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  10. Pneumothorax

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  11. Lipoma

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  12. Cough

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  13. Croup

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  14. Sty

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  15. Essure

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  16. Hypochondria

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  17. Dermatographia

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  18. Snoring

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  19. Appendicitis

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  20. Bone Metastasis

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  1. Bent Penis

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  2. Canker Sore

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  3. Cold Sore

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  4. Nail Fungus

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  5. Ruptured Spleen

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  6. Hodgkin's Lymphoma

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  7. Fetal Macrosomia

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  8. Female Condom

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  9. Cervical Cerclage

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  10. Forceps Delivery

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  11. Prostate Biopsy

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  12. Abdominal Pain

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  13. Intracranial hematoma

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  14. Broken Arm

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  15. Contraceptive Sponge

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  16. Biophysical Profile

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  17. Tubal Ligation

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  18. Cervical Cap

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  19. Lichen Sclerosus

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  20. Alcoholic Hepatitis

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  1. Beta Blockers

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  2. Alpha Blockers

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  3. Krabbe Disease

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  4. Peanut Allergy

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  5. Achilles Tendinitis

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  6. Throat Cancer

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  7. Kidney Cancer

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  8. Bee Stings

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  9. Thunderclap Headaches

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  10. Norovirus Infection

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  11. Asthma Attack

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  12. Factitious Disorder

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  13. Spinal Headaches

    MedlinePlus

    ... Policy Notice of Privacy Practices Notice of Nondiscrimination Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  14. Earwax Blockage

    MedlinePlus

    ... Policy Notice of Privacy Practices Notice of Nondiscrimination Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  15. Presidential address: The origins and evolution of the Mayo Clinic from 1864 to 1939: a Minnesota family practice becomes an international "medical Mecca".

    PubMed

    Fye, W Bruce

    2010-01-01

    This paper describes the origins and international impact of the Mayo Clinic through 1939. Multispecialty group practice was invented at the clinic a century ago. A visiting Canadian physician wrote in 1906, "Specialization and cooperation, with the best that can be had in each department, is here the motto. Cannot these principles be tried elsewhere?" Mayo Clinic's major (and underappreciated) role in the development of rigorous postgraduate (specialty) training is addressed. Unlike traditional academic medical centers that emphasize research, Mayo's main mission has always been patient care. This activity has been undertaken in an environment enriched by extensive programs devoted to specialty training and clinical research.

  16. Pubic Lice (Crabs)

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  17. Premenstrual Syndrome (PMS)

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  18. Diverticulitis Diet

    MedlinePlus

    ... evolving treatment of colonic diverticular disease. Alimentary Pharmacology & Therapeutics. 2009;30:532. AskMayoExpert. Diverticulitis. Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2016. Wilkins T, et al. Diagnosis ...

  19. Fainting: First Aid

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  20. Non-Hodgkin's Lymphoma

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  1. Toothache: First Aid

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  2. Enlarged Spleen (Splenomegaly)

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  3. Addison's Disease: Treatment

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  4. Tubal Ligation Reversal

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  5. Breast Lift (Mastopexy)

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  6. Blood Pressure Test

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  7. Mitral Valve Stenosis

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  8. Shortness of Breath

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  9. Post-Concussion Syndrome

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  10. Nonulcer Stomach Pain

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  11. Oral Lichen Planus

    MedlinePlus

    ... Policy Notice of Privacy Practices Notice of Nondiscrimination Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  12. Recurrent Breast Cancer

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  13. Left Ventricular Hypertrophy

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  14. Benthic diatoms from Potter Cove, 25 de Mayo (King George) Island, Antarctica: Mucilage and glucan storage as a C-source for limpets

    NASA Astrophysics Data System (ADS)

    Daglio, Yasmin; Sacristán, Hernán; Ansaldo, Martín; Rodríguez, María C.

    2018-03-01

    Biofilms were allowed to develop on ceramic tiles placed in closed containers on the shore of Potter Cove, 25 de Mayo (King George) Island. Water pumping from the cove inside the containers extended for 25 days. Diatoms were the dominant microalgae in these biofilms, which were removed from a set of tiles to a) characterize the extracellular mucilage, b) carry out floristic determination and c) perform grazing experiments with the limpet Nacella concinna. Biofilms mucilaginous matrix consisted of proteins and carbohydrates. Room temperature aqueous extraction of the freeze-dried material rendered a fraction enriched in the storage glucan chrysolaminarin, its identity confirmed by methylation structural analyses. Hot water extracted products showed greater heterogeneity in monosaccharide composition, including glucose, mannose, galactose, fucose, xylose and rhamnose. Diatom identification revealed that Pseudogomphonema kamtschaticum was the dominant species followed by several Navicula species, Nitzschia pellucida and Synedra kerguelensis. Photographical survey of colonized tiles placed in glass flasks together with a specimen of Nacella concinna exhibited between 5 and 30% removal of the biofilms coverage after 24 h of exposure to the limpet, suggesting that EPS and chrysolaminarin constitute a C-source for the gastropod.

  15. Motion Sickness: First Aid

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  16. Limited Scleroderma (CREST Syndrome)

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  17. Rh Factor Blood Test

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  18. Yeast Infection during Pregnancy

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  19. Otoplasty (Cosmetic Ear Surgery)

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  20. Acute Myelogenous Leukemia (AML)

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  1. Diet After Gallbladder Removal

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  2. Hypoxemia (Low Blood Oxygen)

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  3. Electrical Shock: First Aid

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  4. Gas and Gas Pains

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  5. Monoamine Oxidase Inhibitors (MAOIs)

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  6. Is Acute Bronchitis Contagious?

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  7. Brain AVM (Arteriovenous Malformation)

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  8. Clueing in customers.

    PubMed

    Berry, Leonard L; Bendapudi, Neeli

    2003-02-01

    Leonard L. Berry and Neeli Bendapudi When customers lack the expertise to judge a company's offerings, they naturally turn detective, scrutinizing people, facilities, and processes for evidence of quality. The Mayo Clinic understands this and carefully manages that evidence to convey a simple, consistent message: The needs of the patient come first. From the way it hires and trains employees to the way it designs its facilities and approaches its care, the Mayo Clinic provides patients and their families concrete evidence of its strengths and values, an approach that has allowed it to build what is arguably the most powerful brand in health care. Marketing professors Leonard Berry and Neeli Bendapudi conducted a five-month study of evidence management at the Mayo Clinic. They interviewed more than 1,000 patients and employees, observed hundreds of doctor visits, traveled in the Mayo helicopter, and stayed in the organization's many hospitals. Their experiences led them to identify best practices applicable to just about any company, in particular those that sell intangible or technically complex products. Essentially, the authors say, companies need to determine what story they want to tell, then ensure that their employees and facilities consistently show customers evidence of that story. At Mayo, the evidence falls into three categories: people, collaboration, and tangibles. The clinic systematically hires people who espouse its values, and its incentive and reward systems promote collaborative care focused on the patient's needs. The physical environment is explicitly designed for its intended effect on the patient experience. In almost every interaction, an organization's message comes through. "Patients first," the Mayo Clinic's message, is not the only story a medical organization could tell, but the way in which Mayo manages evidence to communicate this message is an example to be followed.

  9. Assessment of human long saphenous vein function with minimally invasive harvesting with the Mayo stripper.

    PubMed

    O'Regan, D J; Borland, J A; Chester, A H; Pennell, D J; Yacoub, M; Pepper, J R

    1997-09-01

    The use of the Mayo Stripper to harvest the long saphenous vein has been shown to improve morbidity from leg wound incisions. It has not been universally accepted because of a perceived increase in injury to the venous conduit. To compare the function of undistended autologous long saphenous vein harvested by a Mayo stripper with the traditional 'open' technique in the same patient (n = 12) appearance. Vascular reactivity was assessed in isolated organ baths. Contractile function was measured in response to increasing concentrations (10(-9)-10(-5) mol) of 5-hydroxytryptamine and noradrenaline. This was calculated as a percentage of the maximum contractile response to 90 mM KCl measured in millinewtons (mN) (control 41.4 +/- 12.1, (n = 11), open technique 35.8 +/- 11.1, (n = 11), Mayo stripper 33.7 +/- 15.9, (n = 11)). The endothelial dependent and independent function was assessed with acetylcholine and sodium nitroprusside, respectively. There was no significant difference in response to both constrictors and dilators between vein taken with the Mayo stripper compared with the traditional open technique (n = 6 for each observation; P > 0.05 by ANOVA). Histological examination by light microscopy of the vessel segments removed with the Mayo stripper was unable to show any significant damage to the vessel wall. Both functional and morphological studies were conducted by 'blinded' observers. One-year follow-up with magnetic resonance angiography (MRA) and stress thallium tomography demonstrated a patency rate with lower and upper estimates of 80 and 94%. We have shown that harvesting the long saphenous vein with a Mayo stripper does not compromise vascular reactivity of the long saphenous vein or long-term patency.

  10. Evaluation of DNA Repair Function as a Predictor of Response in a Clinical Trial of PARP Inhibitor Monotherapy for Recurrent Ovarian Carcinoma

    DTIC Science & Technology

    2015-10-01

    Monotherapy for Recurrent Ovarian Carcinoma PRINCIPAL INVESTIGATOR: Scott H. Kaufmann CONTRACTING ORGANIZATION: Mayo Clinic Rochester, MN 55905...UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Mayo Clinic and Foundation AND ADDRESS(ES) 8. PERFORMING ORGANIZATION REPORT...NUMBER 200 First St., S.W. Rochester, MN 55905 9. SPONSORING / MONITORING AGENCY NAME(S) AND ADDRESS(ES) Mayo Clinic Rochester, MN 55905 10. SPONSOR

  11. The Pine Ridge-Mayo National Aeronautics and Space Administration Telemedicine Project: Program Activities and Participant Reactions

    NASA Technical Reports Server (NTRS)

    Kottke, T. E.; Little Finger, L.; Trapp, M. A.; Panser, L. A.; Novotny, P. J.

    1996-01-01

    OBJECTIVE: To determine the response of participants to the Pine Ridge-Mayo National Aeronautics and Space Administration telemedicine project. DESIGN: We describe a 3-month demonstration project of medical education and clinical consultations conducted by means of satellite transmission. Postparticipation questionnaires and a postproject survey were used to assess the success of the activity. MATERIAL AND METHODS: Patients and employees at the Pine Ridge Indian Health Service Hospital in southwestern South Dakota and employees at Mayo Clinic Rochester participated in a telemedicine project, after which they completed exit surveys and a postproject questionnaire to ascertain the acceptability of this mode of health care. RESULTS: Almost all Pine Ridge and Mayo Clinic participants viewed the project as beneficial. The educational sessions received favorable evaluations, and almost two-thirds of the patients who completed evaluations thought the consultation had contributed to their medical care. More than 90% of the respondents from Pine Ridge and more than 85% of the respondents from Mayo Clinic Rochester said that they would recommend participation in this project to others. More than 90% of respondents from Pine Ridge and 80% of Mayo respondents agreed with the statement that the project should continue. CONCLUSION: These data suggest that a program of clinical consultation services, professional education, and patient education available by telemedicine might be viewed as beneficial.

  12. Infant Reflux: Diagnosis and Treatment

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  13. Trichomoniasis

    MedlinePlus

    ... that travels between people during sexual intercourse. The incubation period between exposure and infection is unknown, but ... To lower your risk, use condoms correctly every time you have sex. By Mayo Clinic Staff . Mayo ...

  14. Shift Work: Improving Daytime Sleep

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  15. Cardiac Asthma: What Causes It?

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  16. PSA Test: What's It for?

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  17. Addison's Disease: Symptoms and Causes

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  18. Managing Diabetes: Looking Beyond Carbs

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  19. Sudden Infant Death Syndrome (SIDS)

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  20. Infant Reflux: Symptoms and Causes

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  1. Antidepressants: Can They Lose Effectiveness?

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  2. Low White Blood Cell Count

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  3. Sore Throat: Diagnosis and Treatment

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  4. Cordocentesis

    MedlinePlus

    ... blood will be taken before the procedure for comparison with the fetal blood samples. During the procedure ... Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education ...

  5. Matters of Priority: Herbert Mayo, Charles Bell and Discoveries in the Nervous System

    PubMed Central

    Bradley, James

    2014-01-01

    Between 1822 and the late 1830s a highly personal priority dispute was fought between the celebrated surgeon and anatomist Sir Charles Bell and his ex-student Herbert Mayo. The dispute was over the motor and sensory functions of the Vth and VIIth cranial nerves. Over the course of the 1820s and the 1830s, the competing claims of Bell and Mayo were presented in newspapers, journals, and textbooks. But by the time of Bell’s death in 1842, Mayo had been discredited, a seemingly tragic footnote in the history of nervous discovery. And yet, with the benefit of hindsight, Bell’s case was at best disingenuous. His success was not due to any intrinsic scientific merit in his argument, but rather his ability to create a narrative that undermined the credibility of Mayo. However, only when Mayo’s public performances elided with Bell’s descriptions did this ploy succeed. As a result, the dispute illuminates the importance of credibility to the creation of an idealised scientific medical practitioner. PMID:25284895

  6. Antidepressants: Another Weapon Against Chronic Pain

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  7. Bladder Outlet Obstruction: Causes in Men?

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  8. Abortions: Does It Affect Subsequent Pregnancies?

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  9. Cancer Diagnosis: 11 Tips for Coping

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  10. Hypothyroidism: Can It Cause Peripheral Neuropathy?

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  11. Mindfulness Exercises: How to Get Started

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  12. Children's Nutrition: Tips for Picky Eaters

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  13. Hand Swelling during Exercise: A Concern?

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  14. Zinc for Colds: The Final Word?

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  15. Split Fingernails: Can They Be Prevented?

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  16. Getting Past a Weight-Loss Plateau

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  17. Heat Rash (Prickly Heat or Miliaria)

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  18. Pregnancy Acne: What's the Best Treatment?

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  19. Atkins Diet: What's Behind the Claims?

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  20. STD Testing: What's Right for You

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  1. Men's Health: Prevent the Top Threats

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  2. Alcohol: Does It Affect Blood Pressure?

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  3. Epilepsy Surgery

    MedlinePlus

    ... monitor the brain's activity and detect abnormalities. Single-photon emission computerized tomography (SPECT). The scan image varies ... off anti-seizure drugs after a year or two. By Mayo Clinic Staff . Mayo Clinic Footer Legal ...

  4. Pregorexia: A Legitimate Problem during Pregnancy?

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  5. Cosmetic Surgery: What to Know Beforehand

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  6. Empowering Mayo Clinic Individualized Medicine with Genomic Data Warehousing

    PubMed Central

    Horton, Iain; Lin, Yaxiong; Reed, Gay; Wiepert, Mathieu

    2017-01-01

    Individualized medicine enables better diagnoses and treatment decisions for patients and promotes research in understanding the molecular underpinnings of disease. Linking individual patient’s genomic and molecular information with their clinical phenotypes is crucial to these efforts. To address this need, the Center for Individualized Medicine at Mayo Clinic has implemented a genomic data warehouse and a workflow management system to bring data from institutional electronic health records and genomic sequencing data from both clinical and research bioinformatics sources into the warehouse. The system is the foundation for Mayo Clinic to build a suite of tools and interfaces to support various clinical and research use cases. The genomic data warehouse is positioned to play a key role in enhancing the research capabilities and advancing individualized patient care at Mayo Clinic. PMID:28829408

  7. Empowering Mayo Clinic Individualized Medicine with Genomic Data Warehousing.

    PubMed

    Horton, Iain; Lin, Yaxiong; Reed, Gay; Wiepert, Mathieu; Hart, Steven

    2017-08-22

    Individualized medicine enables better diagnoses and treatment decisions for patients and promotes research in understanding the molecular underpinnings of disease. Linking individual patient's genomic and molecular information with their clinical phenotypes is crucial to these efforts. To address this need, the Center for Individualized Medicine at Mayo Clinic has implemented a genomic data warehouse and a workflow management system to bring data from institutional electronic health records and genomic sequencing data from both clinical and research bioinformatics sources into the warehouse. The system is the foundation for Mayo Clinic to build a suite of tools and interfaces to support various clinical and research use cases. The genomic data warehouse is positioned to play a key role in enhancing the research capabilities and advancing individualized patient care at Mayo Clinic.

  8. Systematic search for wide periodic windows and bounds for the set of regular parameters for the quadratic map.

    PubMed

    Galias, Zbigniew

    2017-05-01

    An efficient method to find positions of periodic windows for the quadratic map f(x)=ax(1-x) and a heuristic algorithm to locate the majority of wide periodic windows are proposed. Accurate rigorous bounds of positions of all periodic windows with periods below 37 and the majority of wide periodic windows with longer periods are found. Based on these results, we prove that the measure of the set of regular parameters in the interval [3,4] is above 0.613960137. The properties of periodic windows are studied numerically. The results of the analysis are used to estimate that the true value of the measure of the set of regular parameters is close to 0.6139603.

  9. Wildfire Smoke

    MedlinePlus

    ... keep the fresh-air intake closed and the filter clean to prevent outdoor smoke from getting inside. ... inside with the windows closed. Use an air filter . Use a freestanding indoor air filter with particle ...

  10. Diabetes Prevention: 5 Tips for Taking Control

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  11. ACL Reconstruction

    MedlinePlus

    ... in surgical procedures of the bones and joints (orthopedic surgeon). Why it's done Ligaments are strong bands ... trademarks of Mayo Foundation for Medical Education and Research. © 1998-2018 Mayo Foundation for Medical Education and ...

  12. Knee Replacement

    MedlinePlus

    ... a knee replacement is right for you, an orthopedic surgeon assesses your knee's range of motion, stability ... trademarks of Mayo Foundation for Medical Education and Research. © 1998-2018 Mayo Foundation for Medical Education and ...

  13. Crying Baby? How to Keep Your Cool

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  14. Retractile Testicle

    MedlinePlus

    ... An inguinal hernia is caused by a small gap in the abdominal lining through which a portion ... trademarks of Mayo Foundation for Medical Education and Research. © 1998-2018 Mayo Foundation for Medical Education and ...

  15. Pneumonia

    MedlinePlus

    ... natural defenses against respiratory infections. Keep your immune system strong. Get enough sleep, exercise regularly and eat a healthy diet. By Mayo Clinic Staff . Mayo Clinic Footer Legal Conditions and Terms Any use of this site ...

  16. Sick Baby? When to Seek Medical Attention

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  17. Erectile Dysfunction: Viagra and Other Oral Medications

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  18. Livedo Reticularis: When Is It a Concern?

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  19. Adult Health: Worried About Empty Nest Syndrome?

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  20. Parenting Tips: How to Improve Toddler Behavior

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  1. Percent Daily Value: What Does It Mean?

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  2. Migraine Medications and Antidepressants: A Risky Mix?

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  3. Wrist Blood Pressure Monitors: Are They Accurate?

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  4. Water Breaking: Understand This Sign of Labor

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  5. Caring for the Elderly: Dealing with Resistance

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  6. Vaccines for Adults: Which Do You Need?

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  7. Nighttime Headaches: How Can I Get Relief?

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  8. Prenatal Yoga: What You Need to Know

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  9. Foot Swelling during Air Travel: A Concern?

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  10. Gallbladder Cleanse: A "Natural" Remedy for Gallstones?

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  11. Foreign Object in the Ear: First Aid

    MedlinePlus

    ... Policy Notice of Privacy Practices Notice of Nondiscrimination Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  12. Byetta, Victoza, Bydureon: Diabetes Drugs and Weight Loss

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  13. Dental Implant Surgery

    MedlinePlus

    ... supplements. If you have certain heart conditions or orthopedic implants, your doctor may prescribe antibiotics before surgery ... trademarks of Mayo Foundation for Medical Education and Research. © 1998-2018 Mayo Foundation for Medical Education and ...

  14. Intermittent Explosive Disorder

    MedlinePlus

    ... explosive disorder have an increased risk of: Impaired interpersonal relationships. They're often perceived by others as ... logo are trademarks of Mayo Foundation for Medical Education and Research. © 1998-2018 Mayo Foundation for Medical ...

  15. Narcissistic Personality Disorder

    MedlinePlus

    ... they don't receive special treatment Have significant interpersonal problems and easily feel slighted React with rage ... logo are trademarks of Mayo Foundation for Medical Education and Research. © 1998-2018 Mayo Foundation for Medical ...

  16. Fallopian Tubes: Is Pregnancy Possible with Only One?

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  17. Male Hypogonadism

    MedlinePlus

    ... Erectile dysfunction Infertility Decrease in beard and body hair growth Decrease in muscle mass Development of breast tissue ( ... Enlarged male breasts (gynecomastia) Decreased beard and body hair growth Osteoporosis By Mayo Clinic Staff . Mayo Clinic Footer ...

  18. Infant Choking: How to Keep Your Baby Safe

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  19. Teen Eating Disorders: Tips to Protect Your Teen

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  20. Diverticulitis Diet: Can Certain Foods Trigger an Attack?

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  1. Fasting Diet: Can It Improve My Heart Health?

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  2. Thumb Sucking: Help Your Child Break the Habit

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  3. Nail Biting: Does It Cause Long-Term Damage?

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  4. Antidepressants: Get Tips to Cope with Side Effects

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  5. Blood Pressure: Is It Affected by Cold Weather?

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  6. Exercising with Osteoporosis: Stay Active the Safe Way

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  7. Fainting during Urination (Micturition Syncope): What Causes It?

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  8. Cancer Survivors: Managing Your Emotions After Cancer Treatment

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  9. Menstrual Cramps (Dysmenorrhea)

    MedlinePlus

    ... during periods (menorrhagia) You have irregular menstrual bleeding (metrorrhagia) You have a family history of menstrual cramps ( ... trademarks of Mayo Foundation for Medical Education and Research. © 1998-2018 Mayo Foundation for Medical Education and ...

  10. Methylmalonic Acid Test

    MedlinePlus

    ... Time and International Normalized Ratio (PT/INR) PSEN1 Quantitative Immunoglobulins Red Blood Cell (RBC) Antibody Identification Red ... 1995-2011). Unit Code 80289: Methylmalonic Acid (MMA), Quantitative, Serum. Mayo Clinic Mayo Medical Laboratories [On-line ...

  11. Priapism: Prolonged Erection

    MedlinePlus

    ... as atomoxetine (Strattera) Alcohol and drug use Alcohol, marijuana, cocaine and other illicit drug abuse can cause ... Clinic logo are trademarks of Mayo Foundation for Medical Education and Research. © 1998-2018 Mayo Foundation for ...

  12. Sexual Problems in Men: MedlinePlus Health Topic

    MedlinePlus

    ... of Serotonin in Female Hypoactive Sexual Desire... Article: Female Sexual Dysfunction-Medical and Psychological Treatments, Committee 14. ... (Mayo Foundation for Medical Education and Research) Sexual Health (Mayo Foundation for Medical ...

  13. Limit Asthma Attacks Caused by Colds or Flu

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  14. Hypothermia: First Aid

    MedlinePlus

    ... t give the person alcohol or cigarettes. Alcohol hinders the rewarming process, and tobacco products interfere with ... logo are trademarks of Mayo Foundation for Medical Education and Research. © 1998-2018 Mayo Foundation for Medical ...

  15. Windows of achievement for development milestones of Sri Lankan infants and toddlers: estimation through statistical modelling.

    PubMed

    Thalagala, N

    2015-11-01

    The normative age ranges during which cohorts of children achieve milestones are called windows of achievement. The patterns of these windows of achievement are known to be both genetically and environmentally dependent. This study aimed to determine the windows of achievement for motor, social emotional, language and cognitive development milestones for infants and toddlers in Sri Lanka. A set of 293 milestones identified through a literature review were subjected to content validation using parent and expert reviews, which resulted in the selection of a revised set of 277 milestones. Thereafter, a sample of 1036 children from 2 months to 30 months was examined to see whether or not they had attained the selected milestones. Percentile ages of attaining milestone were determined using a rearranged closed form equation related to the logistic regression. The parameters required for calculations were derived through the logistic regression of milestone achievement statuses against ages of children. These percentile ages were used to define the respective windows of achievement. A set of 178 robust indicators that represent motor, socio emotional, language and cognitive development skills and their windows of achievement relevant to 2 to 24 months of age were determined. Windows of achievement for six gross motor milestones determined in the study were shown to closely overlap a similar set of windows of achievement published by the World Health Organization indicating the validity of some findings. A methodology combining the content validation based on qualitative techniques and age validation based on regression modelling found to be effective for determining age percentiles for realizing milestones and determining respective windows of achievement. © 2015 John Wiley & Sons Ltd.

  16. UV exposure in cars.

    PubMed

    Moehrle, Matthias; Soballa, Martin; Korn, Manfred

    2003-08-01

    There is increasing knowledge about the hazards of solar and ultraviolet (UV) radiation to humans. Although people spend a significant time in cars, data on UV exposure during traveling are lacking. The aim of this study was to obtain basic information on personal UV exposure in cars. UV transmission of car glass samples, windscreen, side and back windows and sunroof, was determined. UV exposure of passengers was evaluated in seven German middle-class cars, fitted with three different types of car windows. UV doses were measured with open or closed windows/sunroof of Mercedes-Benz E 220 T, E 320, and S 500, and in an open convertible car (Mercedes-Benz CLK). Bacillus subtilis spore film dosimeters (Viospor) were attached to the front, vertex, cheeks, upper arms, forearms and thighs of 'adult' and 'child' dummies. UV wavelengths longer than >335 nm were transmitted through car windows, and UV irradiation >380 nm was transmitted through compound glass windscreens. There was some variation in the spectral transmission of side windows according to the type of glass. On the arms, UV exposure was 3-4% of ambient radiation when the car windows were shut, and 25-31% of ambient radiation when the windows were open. In the open convertible car, the relative personal doses reached 62% of ambient radiation. The car glass types examined offer substantial protection against short-wave UV radiation. Professional drivers should keep car windows closed on sunny days to reduce occupational UV exposure. In individuals with polymorphic light eruption, produced by long-wave UVA, additional protection by plastic films, clothes or sunscreens appears necessary.

  17. Fibromyalgia Symptoms or Not? Understand the Fibromyalgia Diagnosis Process

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  18. Mumps

    MedlinePlus

    ... been raised about a connection between the MMR vaccine and autism, extensive reports from the American Academy of Pediatrics, ... there's no scientifically proven link between the MMR vaccine and autism. By Mayo Clinic Staff . Mayo Clinic Footer Legal ...

  19. First-Aid Kits: Stock Supplies That Can Save Lives

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  20. Is Ear Candling a Safe Way to Remove Earwax?

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  1. Mouth Sores Caused by Cancer Treatment: How to Cope

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  2. What's the Difference Between Vocal Cord Dysfunction and Asthma?

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  3. Fear of Public Speaking: How Can I Overcome It?

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  4. Are Chicken Eggs Good or Bad for My Cholesterol?

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  5. MAOIs and Diet: Is It Necessary to Restrict Tyramine?

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  6. Cancer Fatigue: Why It Occurs and How to Cope

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  7. Dry Macular Degeneration

    MedlinePlus

    ... developing macular degeneration. Include fish in your diet. Omega-3 fatty acids, which are found in fish, may ... macular degeneration. Nuts, such as walnuts, also contain omega-3 fatty acids. By Mayo Clinic Staff . Mayo Clinic ...

  8. Coenzyme Q10: Can It Prevent Statin Side Effects?

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  9. End of Life (Caring for a Dying Loved One)

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  10. Granulomatosis with Polyangiitis (GPA): Symptoms and Causes

    MedlinePlus

    ... of the nose (saddling) caused by weakened cartilage Deep vein thrombosis By Mayo Clinic ... is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does ...

  11. Gallbladder Polyps: Can They Be Cancerous?

    MedlinePlus

    ... with special reference to diagnosis and treatment in China. International Journal of Clinical and Experimental Pathology. 2015; ... logo are trademarks of Mayo Foundation for Medical Education and Research. © 1998-2018 Mayo Foundation for Medical ...

  12. Avulsion Fracture: How Is It Treated?

    MedlinePlus

    ... Marx JA, et al., eds. General principles of orthopedic injuries. In: Rosen's Emergency Medicine: Concepts and Clinical ... trademarks of Mayo Foundation for Medical Education and Research. © 1998-2018 Mayo Foundation for Medical Education and ...

  13. Dislocated Shoulder: Diagnosis and Treatment

    MedlinePlus

    ... the emergency room physician may recommend that an orthopedic surgeon examine the injury. What you can do ... trademarks of Mayo Foundation for Medical Education and Research. © 1998-2018 Mayo Foundation for Medical Education and ...

  14. Blisters: First Aid

    MedlinePlus

    ... healthy traveler. In: Mayo Clinic Guide to Self-Care. 7th ed. Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2017. Brennan FH. Treatment and prevention of foot friction blisters. ACSM's Health & Fitness Journal. 2013;17: ...

  15. HIDA Scan (Cholescintigraphy)

    MedlinePlus

    ... areas. Radioactive tracer found outside of your biliary system might indicate a leak. Your doctor will discuss the results with you. By Mayo Clinic Staff . Mayo Clinic Footer Legal Conditions and Terms Any use of this site ...

  16. Bronchiolitis

    MedlinePlus

    ... a heart-lung condition or a depressed immune system, may be given the medication palivizumab (Synagis) to decrease the likelihood of RSV infections. By Mayo Clinic Staff . Mayo Clinic Footer Legal Conditions and Terms Any use of this site ...

  17. Pap Smear: Do I Need One If I'm a Virgin?

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  18. Can Weight Loss Reduce the Need for Blood Pressure Medication?

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  19. Bipolar Treatment: Are Bipolar I and Bipolar II Treated Differently?

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  20. What Causes a Pseudoaneurysm? Should a Pseudoaneurysm Always be Treated?

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  1. Women's Health: The Biggest Threats to Women's Health are often Preventable.

    MedlinePlus

    ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not ...

  2. Puncture Wounds: First Aid

    MedlinePlus

    ... aid/first-aid-puncture-wounds/basics/ART-20056665 . Mayo Clinic Footer Legal Conditions and Terms Any use of ... Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds ...

  3. GERD: Can Certain Medications Increase Severity?

    MedlinePlus

    ... com/home. Accessed Dec. 31, 2014. Bisphosphonates. Facts & Comparisons. http://www.factsandcomparisons.com. Accessed Dec. 31, 2014. ... Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education ...

  4. Fractures (Broken Bones): First Aid

    MedlinePlus

    First aid Fractures (broken bones) Fractures (broken bones): First aid By Mayo Clinic Staff A fracture is a ... 10, 2018 Original article: http://www.mayoclinic.org/first-aid/first-aid-fractures/basics/ART-20056641 . Mayo Clinic ...

  5. Detailed description of the Mayo/IBM PACS

    NASA Astrophysics Data System (ADS)

    Gehring, Dale G.; Persons, Kenneth R.; Rothman, Melvyn L.; Salutz, James R.; Morin, Richard L.

    1991-07-01

    The Mayo Clinic and IBM/Rochester have jointly developed a picture archiving system (PACS) for use with Mayo's MRI and Neuro-CT imaging modalities. The system was developed to replace the imaging system's vendor-supplied magnetic tape archiving capability. The system consists of seven MR imagers and nine CT scanners, each interfaced to the PACS via IBM Personal System/2(tm) (PS/2) computers, which act as gateways from the imaging modality to the PACS network. The PAC system operates on the token-ring component of Mayo's city-wide local area network. Also on the PACS network are four optical storage subsystems used for image archival, three optical subsystems used for image retrieval, an IBM Application System/400(tm) (AS/400) computer used for database management and multiple PS/2-based image display systems and their image servers.

  6. X-38 on B-52 Wing Pylon - View from Observation Window

    NASA Image and Video Library

    1997-11-19

    A unique, close-up view of the X-38 under the wing of NASA's B-52 mothership prior to launch of the lifting-body research vehicle. The photo was taken from the observation window of the B-52 bomber as it banked in flight.

  7. Comparing effects of soybean oil- and palm olein-based mayonnaise consumption on the plasma lipid and lipoprotein profiles in human subjects: a double-blind randomized controlled trial with cross-over design.

    PubMed

    Karupaiah, Tilakavati; Chuah, Khun-Aik; Chinna, Karuthan; Matsuoka, Ryosuke; Masuda, Yasunobu; Sundram, Kalyana; Sugano, Michihiro

    2016-08-17

    Mayonnaise is used widely in contemporary human diet with widespread use as a salad dressing or spread on breads. Vegetable oils used in its formulation may be a rich source of ω-6 PUFAs and the higher-PUFA content of mayonnaise may be beneficial in mediating a hypocholesterolemic effect. This study, therefore, evaluated the functionality of mayonnaise on cardiometabolic risk within a regular human consumption scenario. Subjects underwent a randomized double-blind crossover trial, consuming diets supplemented with 20 g/day of either soybean oil-based mayonnaise (SB-mayo) or palm olein-based mayonnaise (PO-mayo) for 4 weeks each with a 2-week wash-out period. The magnitude of changes for metabolic outcomes between dietary treatments was compared with PO-mayo serving as the control. The data was analyzed by ANCOVA using the GLM model. Analysis was adjusted for weight changes. Treatments resulted in significant reductions in TC (diff = -0.25 mmol/L; P = 0.001), LDL-C (diff = -0.17 mmol/L; P = 0.016) and HDL-C (diff = -0.12 mmol/L; P < 0.001) in SB-mayo compared to PO-mayo without affecting LDL-C:HDL-C ratio (P > 0.05). Lipoprotein particle change was significant with large LDL particles increasing after PO-mayo (diff = +63.2 nmol/L; P = 0.007) compared to SB-mayo but small LDL particles remained unaffected. Plasma glucose, apolipoproteins and oxidative stress markers remained unchanged. Daily use with 20 g of linoleic acid-rich SB-mayo elicited reductions in TC and LDL-C concentrations without significantly changing LDL-C:HDL-C ratio or small LDL particle distributions compared to the PO-mayo diet. This clinical trial was retrospectively registered with the National Medical Research Register, National Institute of Health, Ministry of Health Malaysia, (NMRR-15-40-24035; registered on 29/01/2015; https://www.nmrr.gov.my/fwbPage.jsp?fwbPageId=ResearchISRForm&fwbAction=Update&fwbStep=10&pk.researchID=24035&fwbVMenu=3&fwbResearchAction=Update ). Ethical approval was obtained from the National University of Malaysia's Medical Ethics Committee (UKM 1.5.3.5/244/SPP/NN-054-2011, approved on 25/05/2011).

  8. Novelty and the 1919 Eclipse Experiments

    NASA Astrophysics Data System (ADS)

    Hudson, Robert G.

    In her 1996 book, Error and the Growth of Experimental Knowledge, Deborah Mayo argues that use- (or heuristic) novelty is not a criterion we need to consider in assessing the evidential value of observations. Using the notion of a "severe" test, Mayo claims that such novelty is valuable only when it leads to severity, and never otherwise. To illustrate her view, she examines the historical case involving the famous 1919 British eclipse expeditions that generated observations supporting Einstein's theory of gravitation over Newton's. My plan here is to defend use-novelty as a valuable methodological principle. I begin by exposing a weakness in Mayo's criticism of use-novelty. Remedying this weakness re-establishes the worth of use-novelty under specific conditions; in particular, heuristically novel data are to be preferred, as I will say, "prima facie". Armed with this revised version of use-novelty, I re-examine the history of the eclipse experiments and offer an interpretation of this episode that to an extent-and contrary to Mayo-restores the mildly heretical, Earman/Glymour evaluation of this episode offered in their (1980). I conclude by responding to criticism of my assessment of Mayo's work.

  9. Rapid execution of fan beam image reconstruction algorithms using efficient computational techniques and special-purpose processors

    NASA Astrophysics Data System (ADS)

    Gilbert, B. K.; Robb, R. A.; Chu, A.; Kenue, S. K.; Lent, A. H.; Swartzlander, E. E., Jr.

    1981-02-01

    Rapid advances during the past ten years of several forms of computer-assisted tomography (CT) have resulted in the development of numerous algorithms to convert raw projection data into cross-sectional images. These reconstruction algorithms are either 'iterative,' in which a large matrix algebraic equation is solved by successive approximation techniques; or 'closed form'. Continuing evolution of the closed form algorithms has allowed the newest versions to produce excellent reconstructed images in most applications. This paper will review several computer software and special-purpose digital hardware implementations of closed form algorithms, either proposed during the past several years by a number of workers or actually implemented in commercial or research CT scanners. The discussion will also cover a number of recently investigated algorithmic modifications which reduce the amount of computation required to execute the reconstruction process, as well as several new special-purpose digital hardware implementations under development in laboratories at the Mayo Clinic.

  10. Impact of ventilation scenario on air exchange rates and on indoor particle number concentrations in an air-conditioned classroom

    NASA Astrophysics Data System (ADS)

    Guo, H.; Morawska, L.; He, C.; Gilbert, D.

    A 2-week intensive measurement campaign of indoor and outdoor air pollution was carried out in September 2006, in a primary school to investigate indoor-outdoor correlations of particle number (PN) concentrations, and the impact of air exchange rate (ACH) on the indoor PN concentration. The ACHs in the classroom for different conditions associated with window opening and the operational status of air conditioners (A/C) and fans were tested. As expected, the lowest ACH (0.12 h -1) was found when the windows were closed and A/C and fans were off. In contrast, the highest ACH (7.92 h -1) was observed when the windows were opened and A/C and fans were all on. The analysis of the PN I/ O ratios at different ACHs in the absence of indoor sources indicates that the mean I/ O ratio was 0.621±0.007 (mean±95% confidence interval) when the windows were closed, and A/C and fans were off; 0.524±0.023 when windows were closed, fans were off and A/C was on; and 0.502±0.029 when windows were closed, A/C was off and fans were on. To further understand the relationship between indoor and outdoor PN concentrations, the impact of outdoor PN concentration on I/ O ratios at different ACHs was investigated. It was found that the relationship between outdoor PN concentration and the I/ O ratio at different ACHs followed a power trendline with an equation of I/ O ratio= A PN out-b ( A and b are coefficients, PN out is outdoor PN concentration), suggesting that the penetration efficiency decreased with increasing outdoor PN concentration. It is the first time we found that when the outdoor PN concentration increased there was an associated increase in the concentration of nano-particles, which have been demonstrated to have higher deposition rates and lower penetration efficiencies. Based on the above equation, the study also showed a significant effect of ACH on indoor PN concentrations under stable outdoor PN concentrations. In general, the higher the ACH was, the lower the indoor PN concentration was.

  11. Tendinitis Pain: Should I Apply Ice or Heat?

    MedlinePlus

    ... Marx JA, et al., eds. General Principles of Orthopedic Injuries. In: Rosen's Emergency Medicine: Concepts and Clinical ... trademarks of Mayo Foundation for Medical Education and Research. © 1998-2018 Mayo Foundation for Medical Education and ...

  12. Degenerative Changes in the Spine: Is This Arthritis?

    MedlinePlus

    ... refer you to a rheumatologist, physical therapist or orthopedic surgeon. With April Chang-Miller, M.D. Osteoarthritis. ... trademarks of Mayo Foundation for Medical Education and Research. © 1998-2018 Mayo Foundation for Medical Education and ...

  13. Chemical Splash in the Eye: First Aid

    MedlinePlus

    ... aid/first-aid-eye-emergency/basics/ART-20056647 . Mayo Clinic Footer Legal Conditions and Terms Any use of ... Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds ...

  14. Daily Aspirin Therapy: Understand the Benefits and Risks

    MedlinePlus

    ... uptodate.com/contents/search. Accessed Nov. 30, 2017. Solomon DH. Nonselective NSAIDs: Adverse cardiovascular effects. https://www. ... trademarks of Mayo Foundation for Medical Education and Research. © 1998-2018 Mayo Foundation for Medical Education and ...

  15. Snacks: How They Fit into Your Weight-Loss Plan

    MedlinePlus

    ... 37 calories 20 pea pods: 28 calories For comparison, one reduced-fat cheese stick has about 60 ... Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education ...

  16. Adjuvant Therapy: Treatment to Keep Cancer from Returning

    MedlinePlus

    ... how well your treatment will work based on comparisons with data from studies of other people with ... Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education ...

  17. Tension-Type Headaches: Self-Care Measures for Relief

    MedlinePlus

    ... Accessed July 6, 2015. Durazzo TC, et al. Comparison of regional brain perfusion levels in chronically smoking ... Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education ...

  18. Depression in Women: Understanding the Gender Gap

    MedlinePlus

    ... al. Depression among low-income women of color: Qualitative findings from cross-cultural focus groups. Journal of ... trademarks of Mayo Foundation for Medical Education and Research. © 1998-2018 Mayo Foundation for Medical Education and ...

  19. The Mayo Clinic Biobank: a building block for individualized medicine.

    PubMed

    Olson, Janet E; Ryu, Euijung; Johnson, Kiley J; Koenig, Barbara A; Maschke, Karen J; Morrisette, Jody A; Liebow, Mark; Takahashi, Paul Y; Fredericksen, Zachary S; Sharma, Ruchi G; Anderson, Kari S; Hathcock, Matthew A; Carnahan, Jason A; Pathak, Jyotishman; Lindor, Noralane M; Beebe, Timothy J; Thibodeau, Stephen N; Cerhan, James R

    2013-09-01

    To report the design and implementation of the first 3 years of enrollment of the Mayo Clinic Biobank. Preparations for this biobank began with a 4-day Deliberative Community Engagement with local residents to obtain community input into the design and governance of the biobank. Recruitment, which began in April 2009, is ongoing, with a target goal of 50,000. Any Mayo Clinic patient who is 18 years or older, able to consent, and a US resident is eligible to participate. Each participant completes a health history questionnaire, provides a blood sample, and allows access to existing tissue specimens and all data from their Mayo Clinic electronic medical record. A community advisory board provides ongoing advice and guidance on complex decisions. After 3 years of recruitment, 21,736 individuals have enrolled. Fifty-eight percent (12,498) of participants are female and 95% (20,541) of European ancestry. Median participant age is 62 years. Seventy-four percent (16,171) live in Minnesota, with 42% (9157) from Olmsted County, where the Mayo Clinic in Rochester, Minnesota, is located. The 5 most commonly self-reported conditions are hyperlipidemia (8979, 41%), hypertension (8174, 38%), osteoarthritis (6448, 30%), any cancer (6224, 29%), and gastroesophageal reflux disease (5669, 26%). Among patients with self-reported cancer, the 5 most common types are nonmelanoma skin cancer (2950, 14%), prostate cancer (1107, 12% in men), breast cancer (941, 4%), melanoma (692, 3%), and cervical cancer (240, 2% in women). Fifty-six percent (12,115) of participants have at least 15 years of electronic medical record history. To date, more than 60 projects and more than 69,000 samples have been approved for use. The Mayo Clinic Biobank has quickly been established as a valuable resource for researchers. Copyright © 2013 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc. All rights reserved.

  20. Erectile Dysfunction

    MedlinePlus

    ... help for anxiety, depression or other mental health concerns. By Mayo Clinic Staff . Mayo Clinic Footer Legal Conditions and Terms Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Terms and Conditions Privacy Policy ...

  1. Cervical Length: Why Does It Matter during Pregnancy?

    MedlinePlus

    ... frequent contractions, a constant low, dull backache, vaginal spotting, or pelvic pressure — your health care provider might ... trademarks of Mayo Foundation for Medical Education and Research. © 1998-2018 Mayo Foundation for Medical Education and ...

  2. End of Life (Supporting a Terminally Ill Loved One)

    MedlinePlus

    ... review in palliative care: A systematic review of quantitative evaluations. Journal of Pain and Symptom Management. 2015; ... trademarks of Mayo Foundation for Medical Education and Research. © 1998-2018 Mayo Foundation for Medical Education and ...

  3. The Enterprise Data Trust at Mayo Clinic: a semantically integrated warehouse of biomedical data

    PubMed Central

    Beck, Scott A; Fisk, Thomas B; Mohr, David N

    2010-01-01

    Mayo Clinic's Enterprise Data Trust is a collection of data from patient care, education, research, and administrative transactional systems, organized to support information retrieval, business intelligence, and high-level decision making. Structurally it is a top-down, subject-oriented, integrated, time-variant, and non-volatile collection of data in support of Mayo Clinic's analytic and decision-making processes. It is an interconnected piece of Mayo Clinic's Enterprise Information Management initiative, which also includes Data Governance, Enterprise Data Modeling, the Enterprise Vocabulary System, and Metadata Management. These resources enable unprecedented organization of enterprise information about patient, genomic, and research data. While facile access for cohort definition or aggregate retrieval is supported, a high level of security, retrieval audit, and user authentication ensures privacy, confidentiality, and respect for the trust imparted by our patients for the respectful use of information about their conditions. PMID:20190054

  4. Image acquisition unit for the Mayo/IBM PACS project

    NASA Astrophysics Data System (ADS)

    Reardon, Frank J.; Salutz, James R.

    1991-07-01

    The Mayo Clinic and IBM Rochester, Minnesota, have jointly developed a picture archiving, distribution and viewing system for use with Mayo's CT and MRI imaging modalities. Images are retrieved from the modalities and sent over the Mayo city-wide token ring network to optical storage subsystems for archiving, and to server subsystems for viewing on image review stations. Images may also be retrieved from archive and transmitted back to the modalities. The subsystems that interface to the modalities and communicate to the other components of the system are termed Image Acquisition Units (LAUs). The IAUs are IBM Personal System/2 (PS/2) computers with specially developed software. They operate independently in a network of cooperative subsystems and communicate with the modalities, archive subsystems, image review server subsystems, and a central subsystem that maintains information about the content and location of images. This paper provides a detailed description of the function and design of the Image Acquisition Units.

  5. Performance characteristics of the Mayo/IBM PACS

    NASA Astrophysics Data System (ADS)

    Persons, Kenneth R.; Gehring, Dale G.; Pavicic, Mark J.; Ding, Yingjai

    1991-07-01

    The Mayo Clinic and IBM (at Rochester, Minnesota) have jointly developed a picture archiving system for use with Mayo's MRI and Neuro CT imaging modalities. The communications backbone of the PACS is a portion of the Mayo institutional network: a series of 4-Mbps token rings interconnected by bridges and fiber optic extensions. The performance characteristics of this system are important to understand because they affect the response time a PACS user can expect, and the response time for non-PACS users competing for resources on the institutional network. The performance characteristics of each component and the average load levels of the network were measured for various load distributions. These data were used to quantify the response characteristics of the existing system and to tune a model developed by North Dakota State University Department of Computer Science for predicting response times of more complex topologies.

  6. The Enterprise Data Trust at Mayo Clinic: a semantically integrated warehouse of biomedical data.

    PubMed

    Chute, Christopher G; Beck, Scott A; Fisk, Thomas B; Mohr, David N

    2010-01-01

    Mayo Clinic's Enterprise Data Trust is a collection of data from patient care, education, research, and administrative transactional systems, organized to support information retrieval, business intelligence, and high-level decision making. Structurally it is a top-down, subject-oriented, integrated, time-variant, and non-volatile collection of data in support of Mayo Clinic's analytic and decision-making processes. It is an interconnected piece of Mayo Clinic's Enterprise Information Management initiative, which also includes Data Governance, Enterprise Data Modeling, the Enterprise Vocabulary System, and Metadata Management. These resources enable unprecedented organization of enterprise information about patient, genomic, and research data. While facile access for cohort definition or aggregate retrieval is supported, a high level of security, retrieval audit, and user authentication ensures privacy, confidentiality, and respect for the trust imparted by our patients for the respectful use of information about their conditions.

  7. Carbon Nanofiber Electrode Array for Neurochemical Monitoring

    NASA Technical Reports Server (NTRS)

    Koehne, Jessica E.

    2017-01-01

    A sensor platform based on vertically aligned carbon nanofibers (CNFs) has been developed. Their inherent nanometer scale, high conductivity, wide potential window, good biocompatibility and well-defined surface chemistry make them ideal candidates as biosensor electrodes. Here, we report using vertically aligned CNF as neurotransmitter recording electrodes for application in a smart deep brain stimulation (DBS) device. Our approach combines a multiplexed CNF electrode chip, developed at NASA Ames Research Center, with the Wireless Instantaneous Neurotransmitter Concentration Sensor (WINCS) system, developed at the Mayo Clinic. Preliminary results indicate that the CNF nanoelectrode arrays are easily integrated with WINCS for neurotransmitter detection in a multiplexed array format. In the future, combining CNF based stimulating and recording electrodes with WINCS may lay the foundation for an implantable smart therapeutic system that utilizes neurochemical feedback control while likely resulting in increased DBS application in various neuropsychiatric disorders. In total, our goal is to take advantage of the nanostructure of CNF arrays for biosensing studies requiring ultrahigh sensitivity, high-degree of miniaturization, and selective biofunctionalization.

  8. Assessing Thermal Comfort Due to a Ventilated Double Window

    NASA Astrophysics Data System (ADS)

    Carlos, Jorge S.; Corvacho, Helena

    2017-10-01

    Building design and its components are the result of a complex process, which should provide pleasant conditions to its inhabitants. Therefore, indoor acceptable comfort is influenced by the architectural design. ISO and ASHRAE standards define thermal comfort as the condition of mind that expresses satisfaction with the thermal environment. The energy demand for heating, beside the building’s physical properties, also depend on human behaviour, like opening or closing windows. Generally, windows are the weakest façade element concerning to thermal performance. A lower thermal resistance allows higher thermal conduction through it. When a window is very hot or cold, and the occupant is very close to it, it may result in thermal discomfort. The functionality of a ventilated double window introduces new physical considerations to a traditional window. In consequence, it is necessary to study the local effect on human comfort in function of the boundary conditions. Wind, solar availability, air temperature and therefore heating and indoor air quality conditions will affect the relationship between this passive system and the indoor environment. In the present paper, the influence of thermal performance and ventilation on human comfort resulting from the construction and geometry solutions is shown, helping to choose the best solution. The presented approach shows that in order to save energy it is possible to reduce the air changes of a room to the minimum, without compromising air quality, enhancing simultaneously local thermal performance and comfort. The results of the study on the effect of two parallel windows with a ventilated channel in the same fenestration on comfort conditions for several different room dimensions, are also presented. As the room dimensions’ rate changes so does the window to floor rate; therefore, under the same climatic conditions and same construction solution, different results are obtained.

  9. The Mayo Clinic Biobank: A building block for individualized medicine

    PubMed Central

    Olson, Janet E.; Ryu, Euijung; Johnson, Kiley J.; Koenig, Barbara A.; Maschke, Karen J.; Morrisette, Jody A.; Liebow, Mark; Takahashi, Paul Y.; Fredericksen, Zachary S.; Sharma, Ruchi G.; Anderson, Kari S.; Hathcock, Matthew A.; Carnahan, Jason A.; Pathak, Jyotishman; Lindor, Noralane M.; Beebe, Timothy J.; Thibodeau, Stephen N.; Cerhan, James R.

    2014-01-01

    OBJECTIVE To report the design and first three years of enrollment of the Mayo Clinic Biobank. PATIENTS AND METHODS Preparations for this Biobank began with a 4-day Deliberative Community Engagement with local residents to obtain community input into the design and governance of the biobank. Recruitment, which began in April 2009, is ongoing with a target goal of 50,000. Any Mayo Clinic patient who is 18+ years, able to consent, and a US resident is eligible to participate. Each participant completes a health history questionnaire, provides a blood sample and allows access to existing tissue specimens and all data from their Mayo Clinic medical record (EMR). A Community Advisory Board provides ongoing advice and guidance on complex decisions. RESULTS After three years of recruitment, 21,736 subjects have enrolled. Participants were 58% female, 95% of European ancestry, and median age of 62 years. Seventy-four percent lived in Minnesota, 42% from Olmsted County where the Mayo Clinic Rochester is located. The five most commonly self-reported conditions were hyperlipidemia (41%), hypertension (38%), osteoarthritis (30%), any cancer (29%), and gastroesophageal reflux disease (26%). Among self-reported cancer patients, the five most common types were non-melanoma skin cancer (14%), prostate cancer (12% in men), breast cancer (4%), melanoma (3%), and cervical cancer (2% in women). Fifty-six percent of participants had at least 15 years of EMR history. To date, over sixty projects and over 69,000 samples have been approved for use. CONCLUSION The Mayo Clinic Biobank has quickly been established as a valuable resource for researchers. PMID:24001487

  10. Laryngospasm: What Causes It?

    MedlinePlus

    ... contents/search. Accessed Jan. 12, 2018. AskMayoExpert. Paradoxical vocal fold motion. Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2017. What is LPR? American Academy of Otolaryngology-Head and Neck Surgery. http://www.entnet.org/?q=node/1449. Accessed ...

  11. Wheat Allergy

    MedlinePlus

    ... and toddlers, who have immature immune and digestive systems. Most children outgrow wheat allergy by 16, but adults can develop it, often as a cross-sensitivity to grass pollen. By Mayo Clinic Staff . Mayo Clinic Footer Legal Conditions and Terms Any use of this site ...

  12. Adaptive variability in the duration of critical windows of plasticity: Implications for the programming of obesity.

    PubMed

    Wells, Jonathan C K

    2014-08-05

    Developmental plasticity underlies widespread associations between early-life exposures and many components of adult phenotype, including the risk of chronic diseases. Humans take almost two decades to reach reproductive maturity, and yet the 'critical windows' of physiological sensitivity that confer developmental plasticity tend to close during fetal life or infancy. While several explanations for lengthy human maturation have been offered, the brevity of physiological plasticity has received less attention. I argue that offspring plasticity is only viable within the niche of maternal care, and that as this protection is withdrawn, the offspring is obliged to canalize many developmental traits in order to minimize environmental disruptions. The schedule of maternal care may therefore shape the duration of critical windows, and since the duration of this care is subject to parent-offspring conflict, the resolution of this conflict may shape the duration of critical windows. This perspective may help understand (i) why windows close at different times for different traits, and (ii) why the duration of critical windows may vary across human populations. The issue is explored in relation to population differences in the association between infant weight gain and later body composition. The occupation of more stable environments by western populations may have favoured earlier closure of the critical window during which growth in lean mass is sensitive to nutritional intake. This may paradoxically have elevated the risk of obesity following rapid infant weight gain in such populations. © The Author(s) 2014. Published by Oxford University Press on behalf of the Foundation for Evolution, Medicine, and Public Health.

  13. Horner Syndrome

    MedlinePlus

    ... at birth Tumor of the hormonal and nervous systems (neuroblastoma) Unknown causes In some cases the cause of Horner syndrome cannot be identified. This is known as idiopathic Horner syndrome. By Mayo Clinic Staff . Mayo Clinic Footer Legal Conditions and Terms Any use of this site ...

  14. Survey for the newly discovered Dan spinymussel in the Dan, Mayo, and South Mayo Rivers, Virginia.

    DOT National Transportation Integrated Search

    2005-01-01

    Three spined, mussel species occur in the United States along the Atlantic slope: James spinymussel (Pleurobema collina), Tar spinymussel (Elliptio steinstansana), and Altamaha spinymussel (E. spinosa). The James spinymussel was listed as endangered ...

  15. CD1a immunopositivity in perivascular epithelioid cell neoplasms: true expression or technical artifact? A streptavidin-biotin and polymer-based detection system immunohistochemical study of perivascular epithelioid cell neoplasms and their morphologic mimics.

    PubMed

    Ahrens, William A; Folpe, Andrew L

    2011-03-01

    Perivascular epithelioid cell neoplasms comprise a family of rare neoplasms composed of morphologically distinctive perivascular epithelioid cells exhibiting a "myomelanocytic" immunophenotype. The distinction of perivascular epithelioid cell neoplasms from other tumors with melanocytic and smooth muscle differentiation can be difficult. A recent study has suggested that perivascular epithelioid cell neoplasms routinely express CD1a, a Langerhans cell-associated transmembrane glycoprotein involved in antigen presentation and that expression of this marker may be helpful in the distinction of perivascular epithelioid cell neoplasms from various mimics. We evaluated a series of perivascular epithelioid cell neoplasms and potential mimics for CD1a expression. A total of 54 cases (27 perivascular epithelioid cell neoplasms, 11 leiomyosarcomas, 10 melanomas, 6 clear cell sarcomas) were evaluated in 2 laboratories (Mayo Clinic Rochester: 31 cases, Carolinas Medical Center: 23 cases). Selected positive cases were retested at Carolinas Medical Center (11 cases) and Mayo Clinic Rochester (10 cases). Mayo Clinic Rochester methods were as follows: MTB1 clone (1:20, Novocastra, Newcastle-upon-Tyne, UK), heat-induced epitope retrieval in EDTA (pH 8.0), and Dako Advance detection system (Dako Corp, Carpinteria, CA) with background-reducing diluent. Carolinas Medical Center methods were as follows: MTB1 clone (1:30; CellMarque, Rocklin, CA), heat-induced epitope retrieval in Medium Cell Conditioner #1 (pH 8.0-9.0), and streptavidin-biotin detection system with diaminobenzidine chromogen, with and without biotin blocking. Scores were as follows: 1+, 5% to 25%; 2+, 26% to 50%; and 3+, more than 51%. Langerhans cells served as a positive internal control in all tested cases. All Mayo Clinic Rochester cases were negative. Sixteen Carolinas Medical Center perivascular epithelioid cell neoplasms (14 renal angiomyolipomas, 1 soft tissue perivascular epithelioid cell neoplasm, 1 pulmonary clear cell "sugar" tumor) showed CD1a immunopositivity (1+: 7 cases; 2+: 7 cases; 3+: 2 cases) when tested without biotin blocking, 11 of these cases were retested with biotin blocking and were negative. All non-perivascular epithelioid cell neoplasms were negative. All positive perivascular epithelioid cell neoplasms showed cytoplasmic staining only, without membranous staining. Ten Carolinas Medical Center positive perivascular epithelioid cell neoplasms were negative when retested a Mayo Clinic Rochester, using a polymer-based detection system. We conclude that perivascular epithelioid cell neoplasms do not truly express CD1a in a biologically plausible membranous pattern, but may instead show aberrant cytoplasmic immunopositivity in some laboratories. Close inspection of published photomicrographs of previously reported CD1a-positive perivascular epithelioid cell neoplasms shows an identical pattern of cytoplasmic positivity, likely reflecting abundant endogenous biotin within perivascular epithelioid cell neoplasm cells. We do not believe that there is a role for CD1a immunohistochemistry in the differential diagnosis of perivascular epithelioid cell neoplasms. Copyright © 2011 Elsevier Inc. All rights reserved.

  16. Time to Second-line Treatment and Subsequent Relative Survival in Older Patients With Relapsed Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma.

    PubMed

    Ammann, Eric M; Shanafelt, Tait D; Larson, Melissa C; Wright, Kara B; McDowell, Bradley D; Link, Brian K; Chrischilles, Elizabeth A

    2017-12-01

    Novel targeted therapies offer excellent short-term outcomes in patients with chronic lymphocytic leukemia and small lymphocytic lymphoma (CLL/SLL). However, there is disagreement over how widely these therapies should be used in place of standard chemo-immunotherapy (CIT). We investigated whether stratification on the length of the interval between first-line (T1) and second-line (T2) treatments could identify a subgroup of older patients with relapsed CLL/SLL with an expectation of normal overall survival, and for whom CIT could be an acceptable treatment choice. Patients with relapsed CLL/SLL who received T2 were identified from the SEER-Medicare Linked Database. Five-year relative survival (RS5; ie, the ratio of observed survival to expected survival based on population life tables) was assessed after stratifying patients on the interval between T1 and T2. We then validated our findings in the Mayo Clinic CLL Database. Among 1974 SEER-Medicare patients (median age = 77 years) who received T2 for relapsed CLL/SLL, longer time-to-retreatment was associated with a modestly improved prognosis (P = .01). However, even among those retreated ≥ 3 years after T1, survival was poor compared with the general population (RS5 = 0.50 or lower in SEER-Medicare). Similar patterns were observed in the younger Mayo validation cohort, although prognosis was better overall among the Mayo patients, and patients with favorable fluorescence in situ hybridization retreated ≥ 3 years after T1 had close to normal expected survival (RS5 = 0.87). Further research is needed to quantify the degree to which targeted therapies provide meaningful improvements over CIT in long-term outcomes for older patients with relapsed CLL/SLL. Copyright © 2017 Elsevier Inc. All rights reserved.

  17. Ultrafine particle exposures while walking, cycling, and driving along an urban residential roadway

    NASA Astrophysics Data System (ADS)

    Quiros, David C.; Lee, Eon S.; Wang, Rui; Zhu, Yifang

    2013-07-01

    Elevated concentrations of ultrafine particles (UFPs, <0.1 μm), which have been linked to adverse health effects, are commonly found along roadways. This study reports UFP and PM2.5 concentrations and respiratory exposures among four transportation modes on an urban residential street in Santa Monica, California while walking, cycling, and driving with windows open and windows closed (with air recirculation on). Repeated measurements were made for nine days during morning (7:30-9:30), afternoon (12:30-14:30), and evening (17:00-19:00) periods. Median UFP concentrations ranged 1-3 × 104 particles cm-3, were 70% lower in afternoon or evening periods compared to the morning, and were 60% lower when driving with windows closed than open. Median PM2.5 ranged 2-15 μg m-3, well below the annual National Ambient Air Quality standard of 15 μg m-3. Respiratory UFP exposure (particles inhaled trip-1) was ˜2 times higher while driving with windows open, ˜15 times higher when cycling, and ˜30 times higher walking, than driving with windows closed. During one evening session with perpendicular rather than parallel wind conditions, absolute UFP concentration was 80% higher, suggesting influence of off-roadway sources. Under parallel wind conditions, a parameter called emissions-weighted traffic volume, used to account for higher and lower emitting vehicles, was correlated with beach-site-subtracted UFP using second-order polynomial model (R2 = 0.61). Based on this model, an 83% on-roadway UFP reduction could be achieved by (1) requiring all trucks to meet California 2007 model-year engine standards, (2) reducing light-duty vehicle flows by 25%, and (3) replacing high-emitting light-duty vehicles (pre 1978) with newer 2010 fleet-average vehicles.

  18. Adaptive variability in the duration of critical windows of plasticity

    PubMed Central

    Wells, Jonathan C. K.

    2014-01-01

    Developmental plasticity underlies widespread associations between early-life exposures and many components of adult phenotype, including the risk of chronic diseases. Humans take almost two decades to reach reproductive maturity, and yet the ‘critical windows’ of physiological sensitivity that confer developmental plasticity tend to close during fetal life or infancy. While several explanations for lengthy human maturation have been offered, the brevity of physiological plasticity has received less attention. I argue that offspring plasticity is only viable within the niche of maternal care, and that as this protection is withdrawn, the offspring is obliged to canalize many developmental traits in order to minimize environmental disruptions. The schedule of maternal care may therefore shape the duration of critical windows, and since the duration of this care is subject to parent–offspring conflict, the resolution of this conflict may shape the duration of critical windows. This perspective may help understand (i) why windows close at different times for different traits, and (ii) why the duration of critical windows may vary across human populations. The issue is explored in relation to population differences in the association between infant weight gain and later body composition. The occupation of more stable environments by western populations may have favoured earlier closure of the critical window during which growth in lean mass is sensitive to nutritional intake. This may paradoxically have elevated the risk of obesity following rapid infant weight gain in such populations. PMID:25095791

  19. ASTP (SA-210) Launch vehicle operational flight trajectory. Part 3: Final documentation

    NASA Technical Reports Server (NTRS)

    Carter, A. B.; Klug, G. W.; Williams, N. W.

    1975-01-01

    Trajectory data are presented for a nominal and two launch window trajectory simulations. These trajectories are designed to insert a manned Apollo spacecraft into a 150/167 km. (81/90 n. mi.) earth orbit inclined at 51.78 degrees for rendezvous with a Soyuz spacecraft, which will be orbiting at approximately 225 km. (121.5 n. mi.). The launch window allocation defined for this launch is 500 pounds of S-IVB stage propellant. The launch window opening trajectory simulation depicts the earliest launch time deviation from a planar flight launch which conforms to this constraint. The launch window closing trajectory simulation was developed for the more stringent Air Force Eastern Test Range (AFETR) flight azimuth restriction of 37.4 degrees east-of-north. These trajectories enclose a 12.09 minute launch window, pertinent features of which are provided in a tabulation. Planar flight data are included for mid-window reference.

  20. Effects of window size and shape on accuracy of subpixel centroid estimation of target images

    NASA Technical Reports Server (NTRS)

    Welch, Sharon S.

    1993-01-01

    A new algorithm is presented for increasing the accuracy of subpixel centroid estimation of (nearly) point target images in cases where the signal-to-noise ratio is low and the signal amplitude and shape vary from frame to frame. In the algorithm, the centroid is calculated over a data window that is matched in width to the image distribution. Fourier analysis is used to explain the dependency of the centroid estimate on the size of the data window, and simulation and experimental results are presented which demonstrate the effects of window size for two different noise models. The effects of window shape were also investigated for uniform and Gaussian-shaped windows. The new algorithm was developed to improve the dynamic range of a close-range photogrammetric tracking system that provides feedback for control of a large gap magnetic suspension system (LGMSS).

  1. Research Guides Mayo Clinic's Recruitment, Retention Efforts.

    ERIC Educational Resources Information Center

    Nayar, Veena R.; Morrey, Michael A.; Schneider, Kenneth J.; Purrington, Anne W.; Wilshusen, Laurie L.; Mullen, Michael P.; Seltman, Kent D.

    2001-01-01

    Discusses a collaborative study between Mayo Clinic's departments of human resources and marketing to identify the factors that influence candidates' decisions to accept or decline job offers and the reasons behind staff resignations. Study aimed to increase the effectiveness of employee recruitment advertising, streamline its interviewing…

  2. 77 FR 70681 - Special Local Regulations; 2012 Holiday Boat Parades, Captain of the Port Miami Zone; FL

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-27

    ... east of the Glynn Mayo Highway Bridge in Jupiter, FL. A special local regulation was previously... Palm Beach and end at Loxahatchee River Daymark 7 east of the Glynn Mayo Highway Bridge in Jupiter, FL...

  3. Validation of the Mayo Hip Score: construct validity, reliability and responsiveness to change.

    PubMed

    Singh, Jasvinder A; Schleck, Cathy; Harmsen, W Scott; Lewallen, David G

    2016-01-19

    Previous studies have provided the initial evidence for construct validity and test-retest reliability of the Mayo Hip Score. Instruments used for Total Hip Arthroplasty (THA) outcomes assessment should be valid, reliable and responsive to change. Our main objective was to examine the responsiveness to change, association with subsequent revision and the construct validity of the Mayo hip score. Discriminant ability was assessed by calculating effect size (ES), standardized response mean (SRM) and Guyatt's responsiveness index (GRI). Minimal clinically important difference (MCII) and moderate improvement thresholds were calculated. We assessed construct validity by examining association of scores with preoperative patient characteristics and correlation with Harris hip score, and assessed association of scores with the risk of subsequent revision. Five thousand three hundred seven provided baseline data; of those with baseline data, 2,278 and 2,089 (39%) provided 2- and 5-year data, respectively. Large ES, SRM and GRI ranging 2.66-2.78, 2.42-2.61 and 1.67-1.88 were noted for Mayo hip scores with THA, respectively. The MCII and moderate improvement thresholds were 22.4-22.7 and 39.4-40.5 respectively. Hazard ratios of revision surgery were higher with lower final score or less improvement in Mayo hip score at 2-years and borderline significant/non-significant at 5-years, respectively: (1) score ≤55 with hazard ratios of 2.24 (95% CI, 1.45, 3.46; p = 0.0003) and 1.70 (95% CI, 1.00, 2.92; p = 0.05) of implant revision subsequently, compared to 72-80 points; (2) no improvement or worsening score with hazard ratios 3.94 (95% CI, 1.50, 10.30; p = 0.005) and 2.72 (95% CI, 0.85,8.70; p = 0.09), compared to improvement >50-points. Mayo hip score had significant positive correlation with younger age, male gender, lower BMI, lower ASA class and lower Deyo-Charlson index (p ≤ 0.003 for each) and with Harris hip scores (p < 0.001). Mayo Hip Score is valid, sensitive to change and associated with future risk of revision surgery in patients with primary THA.

  4. Comparison of the EZ-Cap recapper with the Mayo recapper for the prevention of needlesticks.

    PubMed

    Dewhirst, Chad A; Hung, Joseph C

    2008-09-01

    The purpose of this project was the development of a device that improves the design of our current capping block, the Mayo recapper. The major challenges for design and improvement included creating a device that is simple to use and can be applied throughout our department. We wanted a recapper device that increased safety and minimized the potential for needlesticks. Simplicity was another important factor, along with versatility and low cost. A new recapper, called EZ-Cap, was developed, and a comparison study was conducted to evaluate the pros and cons of the EZ-Cap recapper and the Mayo recapper. Nuclear medicine technologists (n = 10) in our department used each device when administering patient injections. At the conclusion of their patient injection rotation, they recorded on a survey sheet the pros and cons of each device. The results of this survey were used to evaluate the effectiveness, comfort level during use, and safety of each recapping device. We used a 2-level scoring system to help determine which device was more favorable. The first level focused on comfort and convenience and was given a score of +1 or -1. The second level focused on safety and was given a score of +2 or -2. Because we believed that safety was a high priority for our capping blocks, this level received a higher score than the first level. The Mayo recapper was the device preferred by 9 of 10 technologists surveyed. The EZ-Cap recapper had several technical issues that made it difficult to use and that could potentially lead to safety concerns. According to our scoring system, the Mayo recapper received a score of +9 for its pros and -4 for its cons. By comparison, the EZ-Cap recapper received a score of +7 for its pros and -16 for its cons. Our results show that the Mayo recapper was the device of choice because its pros outweighed its cons. However, we will continually improve the effectiveness of the Mayo recapper to prevent needlesticks.

  5. Compound windows of the Hénon-map

    NASA Astrophysics Data System (ADS)

    Lorenz, Edward N.

    2008-08-01

    For the two-parameter second-order Hénon map, the shapes and locations of the periodic windows-continua of parameter values for which solutions x0,x1,… can be stably periodic, embedded in larger regions where chaotic solutions or solutions of other periods prevail-are found by a random searching procedure and displayed graphically. Many windows have a typical shape, consisting of a central “body” from which four narrow “antennae” extend. Such windows, to be called compound windows, are often arranged in bands, to be called window streets, that are made up largely of small detected but poorly resolved compound windows. For each fundamental subwindow-the portion of a window where a fundamental period prevails-a stability measure U is introduced; where the solution is stable, |U|<1. Curves of constant U are found by numerical integration. Along one line in parameter space the Hénon-map reduces to the one-parameter first-order logistic map, and two antennae from each compound window intersect this line. The curves where U=1 and U=-1 that bound either antenna are close together within these intersections, but, as either curve with U=-1 leaves the line, it diverges from the curve where U=1, crosses the other curve where U=-1, and nears the other curve where U=1, forming another antenna. The region bounded by the numerically determined curves coincides with the subwindow as found by random searching. A fourth-degree equation for an idealized curve of constant U is established. Points in parameter space producing periodic solutions where x0=xm=0, for given values of m, are found to lie on Cantor sets of curves that closely fit the window streets. Points producing solutions where x0=xm=0 and satisfying a third condition, approximating the condition that xn be bounded as n→-∞, lie on curves, to be called street curves of order m, that approximate individual members of the Cantor set and individual window streets. Compound windows of period m+m‧ tend to occur near the intersections of street curves of orders m and m‧. Some exceptions to what appear to be fairly general results are noted. The exceptions render it difficult to establish general theorems.

  6. 77 FR 66938 - Special Local Regulations; 2012 Holiday Boat Parades, Captain of the Port Miami Zone; FL

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-08

    ... North Palm Beach and end at Loxahatchee River Daymark 7 east of the Glynn Mayo Highway Bridge in Jupiter... Loxahatchee River Daymark 7 east of the Glynn Mayo Highway Bridge in Jupiter, FL, which will include a buffer...

  7. 23. RW Meyer Sugar Mill: 18761889. Boiling House Interior, 1878. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    23. RW Meyer Sugar Mill: 1876-1889. Boiling House Interior, 1878. View: North Wall of boiling house. In the original structure the three windows on the right admitted light and air from the outside. A shed occupied the left side of the wall outside (hence no windows). in 1881 the construction of the cooling shed closed in the right three windows. The sorghum is in the foreground. The centrifugals are in the left rear. - R. W. Meyer Sugar Mill, State Route 47, Kualapuu, Maui County, HI

  8. Faithful reconstruction of digital holograms captured by FINCH using a Hamming window function in the Fresnel propagation.

    PubMed

    Siegel, Nisan; Rosen, Joseph; Brooker, Gary

    2013-10-01

    Recent advances in Fresnel incoherent correlation holography (FINCH) increase the signal-to-noise ratio in hologram recording by interference of images from two diffractive lenses with focal lengths close to the image plane. Holograms requiring short reconstruction distances are created that reconstruct poorly with existing Fresnel propagation methods. Here we show a dramatic improvement in reconstructed fluorescent images when a 2D Hamming window function substituted for the disk window typically used to bound the impulse response in the Fresnel propagation. Greatly improved image contrast and quality are shown for simulated and experimentally determined FINCH holograms using a 2D Hamming window without significant loss in lateral or axial resolution.

  9. Principles and process in the development of the Mayo Clinic's individual and institutional conflict of interest policy.

    PubMed

    Camilleri, Michael; Gamble, Gail L; Kopecky, Stephen L; Wood, Michael B; Hockema, Marianne L

    2005-10-01

    In 1995, federal regulations required all academic medical centers to implement policies to manage individual financial conflict of interest. At the Mayo Clinic, all staff are salaried, and all medically related intellectual property from the staff belongs to the clinic. Hence, it was necessary to develop a policy for institutional conflict of interest to complement the policy for individual conflicts of interest. This article addresses the principles and process that led to the development of the Mayo Clinic's policies that guide the management of conflict of interest of individuals and of the institution. Empowered by the Bayh-Dole Act, the Mayo Clinic participates in technology transfer through its entity Mayo Medical Ventures. Individual conflicts of interest arising from such technology transfer are associated with Institutional conflicts because all individual intellectual property belongs to the institution, per clinic policy. This policy addresses conflicts of interest that arise in research, leadership, clinical practice, investments, and purchasing. Associated with the statutory annual disclosure on personal consulting and other relationships with Industry, which are guided by federal regulations, all research protocols or grant applications require financial disclosure on initial submission and in annual progress reports. The clinic's Conflict of Interest Review Board was established to review each disclosure and recommend management of individual and institutional conflicts of interest according to policy.

  10. Pestalozzi and James Pierrepont Greaves: A Shared Educational Philosophy.

    ERIC Educational Resources Information Center

    Latham, Jackie E. M.

    2002-01-01

    Focuses on Johann H. Pestalozzi, James Pierrepont Greaves, and Reverend Charles Mayo. States that Greaves and Mayo disseminated Pestalozzi's ideas and techniques in England. Explains that Pestalozzi and Greaves trained elementary teachers to view students' talents and personal growth as a whole person concept. Argues less effort would limit…

  11. How Can Positive Effects of Pop-Up Windows on Multimedia Learning Be Explained?

    ERIC Educational Resources Information Center

    Erhel, Severine; Jamet, Eric

    2011-01-01

    A large body of research has shown that incorporating text in the corresponding sections of an illustration facilitates the learning of illustrated documents. More recently, a series of studies has revealed that the use of interactive windows located close to the illustration causes similar effects. The aim of this paper is to help bring about a…

  12. Effects of leukocyte-platelet rich fibrin on postoperative complications of direct sinus lifting.

    PubMed

    Gurler, Gokhan; Delilbasi, Cagri

    2016-08-01

    Blood products have been widely used in soft tissue and bone regeneration in oral and maxillofacial surgery. The purpose of this study is to evaluate the effects of leukocyte-platelet rich fibrin (L-PRF) following direct sinus lifting procedure. Twenty-eight patients were included in the study. Direct sinus lifting was performed via lateral window approach under conscious sedation and local anesthesia. Bony window and sinus floor elevation were performed using piezosurgery device. Two groups were formed. In the first group an allogenous bone graft and L-PRF mixture was used as grafting material. The L-PRF membrane was used to close the lateral window. In the second group, only allogenous bone was used for grafting and resorbable collagen membrane was used to close the lateral window. Pain, swelling, sleeping, eating, phonetics, activities of daily living, missed work days and soft tissue healing were evaluated postoperatively. Data of 24 patients were evaluated. Improvements were seen in the studied parameters in the L-PRF group; however, the difference was not significant between the two groups (P>0.05). The use of L-PRF and allogenous bone graft in combination with L-PRF membrane does not significantly improve postoperative complications following direct sinus lifting.

  13. Origins of Cardiovascular Surgery at the Mayo Clinic.

    PubMed

    Arghami, Arman; Dearani, Joseph A; Schaff, Hartzell V; Puga, Francisco J; Daly, Richard C

    2016-01-01

    Sixty years ago, at the Mayo Clinic in Rochester, Minnesota, an ambitious group of pioneers, led by Dr John W. Kirklin and supported by a multidisciplinary team of physicians and technicians embarked on a planned series of surgical cases using a heart-lung machine to allow direct visualization of the inside of the opened human heart to repair otherwise fatal congenital intracardiac defects. Their success sparked the beginning of a new era of open-heart surgery. In this historical article, we discuss the contributions of a few key figures of this revolution and also share the story of the first successful cardiac surgery operation using cardiopulmonary bypass performed at Mayo Clinic. Copyright © 2016 Elsevier Inc. All rights reserved.

  14. Mexican American Youth Organization: Avant-Garde of the Chicano Movement in Texas.

    ERIC Educational Resources Information Center

    Navarro, Armando

    Among the protest movements of the 1960s, the Mexican American Youth Organization (MAYO) emerged as one of the principal Chicano organizations seeking social change. This in-depth study of MAYO is based on interviews, letters, diaries, position papers, participant observations, and secondary sources such as newspapers and articles. The…

  15. A New Library for Galway-Mayo Institute of Technology

    ERIC Educational Resources Information Center

    Kelly, Hugh

    2004-01-01

    The newly-built library at Ireland's Galway-Mayo Institute of Technology (GMIT) is innovative in design, responds to environmental conditions and identifies the campus with its location. The library is part of the Learning Resource Centre recently constructed to meet the institute's objective for a new landmark frontage. This article presents the…

  16. Optical performance of segmented aperture windows for solar tower receivers

    NASA Astrophysics Data System (ADS)

    Buck, Reiner

    2017-06-01

    Segmented quartz windows are a concept to build larger windows for receivers that require a closed aperture. Reflection losses are a significant loss factor for such solar receivers. Without any additional measures, the reflection loss can reach about 12%. One important measure to improve transmission is the application of anti-reflective coatings, which is beneficial in any case. Another option is modifying the window geometry, especially the edge surfaces of the glass segments. A certain fraction of the reflection losses are caused by a light-guide effect in the glass body, for rays entering through the front surface. Changing the cut surfaces in a way reducing the light-guide effect can significantly improve transmission of a segmented window. Several possible configurations are evaluated and discussed. The results of ray-tracing simulations verify the improvement. The final selection of the window configuration depends on the optical properties and on mechanical strength, manufacturing and cost considerations. This has to be evaluated for any specific receiver design.

  17. Temperature rise and Heat build up inside a parked Car

    NASA Astrophysics Data System (ADS)

    Coady, Rose; Maheswaranathan, Ponn

    2001-11-01

    We have studied the heat build up inside a parked car under the hot summer Sun. Inside and outside temperatures were monitored every ten seconds from 9 AM to about 4 PM for a 2000 Toyota Camry parked in a Winthrop University parking lot without any shades or trees. Two PASCO temperature sensors, one inside the car and the other outside the car, are used along with PASCO-750 interface to collect the data. Data were collected under the following conditions while keeping track of the outside weather: fully closed windows, slightly open windows, half way open windows, fully open windows, and with window shades inside and outside. Inside temperatures reached as high as 150 degrees Fahrenheit on a sunny day with outside high temperature of about 100 degrees Fahrenheit. These results will be presented along with results from car cover and window tint manufacturers and suggestions to keep your car cool next time you park it under the Sun.

  18. External Survey from Windows in Mini-Research Modules and Pirs Docking Compartment

    NASA Image and Video Library

    2013-04-03

    ISS035-E-013901 (3 April 2013) --- This close-up picture of a Zvezda Service Module array, reflecting bright rays of the sun, thus creating an artistic scene, was photographed on April 3 by one of the Expedition 35 crew members as part of an External Survey from International Space Station windows that was recently added to the crew's task list.

  19. Closeup view of the upper exterior of the forward fuselage ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Close-up view of the upper exterior of the forward fuselage of the Orbiter Discovery in the Orbiter Processing Facility at NASA's Kennedy Space Center. The view show a detail of the flight deck windows with protective covers installed to protect the window surfaces during processing. - Space Transportation System, Orbiter Discovery (OV-103), Lyndon B. Johnson Space Center, 2101 NASA Parkway, Houston, Harris County, TX

  20. Evaluation of Energy Efficiency Performance of Heated Windows

    NASA Astrophysics Data System (ADS)

    Jammulamadaka, Hari Swarup

    The study about the evaluation of the performance of the heated windows was funded by the WVU Research Office as a technical assistance award at the 2014 TransTech Energy Business Development Conference to the Green Heated Glass company/project owned by Frank Dlubak. The award supports a WVU researcher to conduct a project important for commercialization. This project was awarded to the WVU Industrial Assessment Center in 2015. The current study attempted to evaluate the performance of the heated windows by developing an experimental setup to test the window at various temperatures by varying the current input to the window. The heated double pane window was installed in an insulated box. A temperature gradient was developed across the window by cooling one side of the window using gel based ice packs. The other face of the window was heated by passing current at different wattages through the window. The temperature of the inside and outside panes, current and voltage input, room and box temperature were recorded, and used to calculate the apparent R-value of the window when not being heated vs when being heated. It has been concluded from the study that the heated double pane window is more effective in reducing heat losses by as much as 50% than a non-heated double pane window, if the window temperature is maintained close to the room temperature. If the temperature of the window is much higher than the room temperature, the losses through the window appear to increase beyond that of a non-heated counterpart. The issues encountered during the current round of experiments are noted, and recommendations provided for future studies.

  1. Preemptive genotyping for personalized medicine: design of the right drug, right dose, right time-using genomic data to individualize treatment protocol.

    PubMed

    Bielinski, Suzette J; Olson, Janet E; Pathak, Jyotishman; Weinshilboum, Richard M; Wang, Liewei; Lyke, Kelly J; Ryu, Euijung; Targonski, Paul V; Van Norstrand, Michael D; Hathcock, Matthew A; Takahashi, Paul Y; McCormick, Jennifer B; Johnson, Kiley J; Maschke, Karen J; Rohrer Vitek, Carolyn R; Ellingson, Marissa S; Wieben, Eric D; Farrugia, Gianrico; Morrisette, Jody A; Kruckeberg, Keri J; Bruflat, Jamie K; Peterson, Lisa M; Blommel, Joseph H; Skierka, Jennifer M; Ferber, Matthew J; Black, John L; Baudhuin, Linnea M; Klee, Eric W; Ross, Jason L; Veldhuizen, Tamra L; Schultz, Cloann G; Caraballo, Pedro J; Freimuth, Robert R; Chute, Christopher G; Kullo, Iftikhar J

    2014-01-01

    To report the design and implementation of the Right Drug, Right Dose, Right Time-Using Genomic Data to Individualize Treatment protocol that was developed to test the concept that prescribers can deliver genome-guided therapy at the point of care by using preemptive pharmacogenomics (PGx) data and clinical decision support (CDS) integrated into the electronic medical record (EMR). We used a multivariate prediction model to identify patients with a high risk of initiating statin therapy within 3 years. The model was used to target a study cohort most likely to benefit from preemptive PGx testing among the Mayo Clinic Biobank participants, with a recruitment goal of 1000 patients. We used a Cox proportional hazards model with variables selected through the Lasso shrinkage method. An operational CDS model was adapted to implement PGx rules within the EMR. The prediction model included age, sex, race, and 6 chronic diseases categorized by the Clinical Classifications Software for International Classification of Diseases, Ninth Revision codes (dyslipidemia, diabetes, peripheral atherosclerosis, disease of the blood-forming organs, coronary atherosclerosis and other heart diseases, and hypertension). Of the 2000 Biobank participants invited, 1013 (51%) provided blood samples, 256 (13%) declined participation, 555 (28%) did not respond, and 176 (9%) consented but did not provide a blood sample within the recruitment window (October 4, 2012, through March 20, 2013). Preemptive PGx testing included CYP2D6 genotyping and targeted sequencing of 84 PGx genes. Synchronous real-time CDS was integrated into the EMR and flagged potential patient-specific drug-gene interactions and provided therapeutic guidance. This translational project provides an opportunity to begin to evaluate the impact of preemptive sequencing and EMR-driven genome-guided therapy. These interventions will improve understanding and implementation of genomic data in clinical practice. Copyright © 2014 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc. All rights reserved.

  2. Mayo's Older Americans Normative Studies (MOANS): Factor Structure of a Core Battery.

    ERIC Educational Resources Information Center

    Smith, Glenn E.; And Others

    1992-01-01

    Using the Mayo Older Americans Normative Studies (MOANS) group (526 55-to 97-year-old adults), factor models were examined for the Wechsler Adult Intelligence Scale-Revised (WAIS-R); the Wechsler Memory Scale (WMS); and a core battery of the WAIS-R, the WMS, and the Rey Auditory-Verbal Learning Test. (SLD)

  3. The Arabic Version of the Mayo-Portland Adaptability Inventory 4: A Validation Study

    ERIC Educational Resources Information Center

    Hamed, Razan; Tariah, Hashem Abu; Malkawi, Somaya; Holm, Margo B.

    2012-01-01

    The Mayo-Portland Adaptability Inventory 4 (MPAI-4) is a valid and reliable assessment tool to detect clinical impairments in patients with acquired brain injury. The tool is widely used by rehabilitation therapists worldwide, given its good psychometric properties and its availability in several languages. The purpose of this study was to…

  4. Magmatismes tholéiitique et alcalin des demi-grabens crétacés de Mayo Oulo Léré et de Babouri Figuil (Nord du Cameroun Sud du Tchad) en domaine d'extension continentaleTholeiitic and alkaline magmatisms of the Early-Cretaceous half-grabens of Mayo Oulo Léré and Babouri Figuil (Northern Cameroon Southern Chad) in extensional structural settings

    NASA Astrophysics Data System (ADS)

    Ngounouno, Ismaı̈la; Déruelle, Bernard; Guiraud, René; Vicat, Jean-Paul

    2001-08-01

    Two major dykes of basalts, microgabbros, olivine dolerites (continental tholeiites), and of camptonites and benmoreites (alkaline rocks) are respectively exposed in the Mayo Oulo-Léré and Babouri-Figuil Early Cretaceous half-grabens (Northern Cameroon-Southern Chad). The tholeiites were probably derived from an asthenospheric source in connection with a lithospheric thinning occurring between Santonian and Eocene times. In contrast, the alkaline rocks may be derived from a deeper metasomatized mantle source.

  5. Reducing indoor air pollution by air conditioning is associated with improvements in cardiovascular health among the general population.

    PubMed

    Lin, Lian-Yu; Chuang, Hsiao-Chi; Liu, I-Jung; Chen, Hua-Wei; Chuang, Kai-Jen

    2013-10-01

    Indoor air pollution is associated with cardiovascular effects, however, little is known about the effects of improving indoor air quality on cardiovascular health. The aim of this study was to explore whether improving indoor air quality through air conditioning can improve cardiovascular health in human subjects. We recruited a panel of 300 healthy subjects from Taipei, aged 20 and over, to participate in six home visits each, to measure a variety of cardiovascular endpoints, including high sensitivity-C-reactive protein (hs-CRP), 8-hydroxy-2'-deoxyguanosine (8-OHdG), fibrinogen in plasma and heart rate variability (HRV). Indoor particles and total volatile organic compounds (VOCs) were measured simultaneously at the participant's home during each visit. Three exposure conditions were investigated in this study: participants were requested to keep their windows open during the first two visits, close their windows during the next two visits, and close the windows and turn on their air conditioners during the last two visits. We used linear mixed-effects models to associate the cardiovascular endpoints with individual indoor air pollutants. The results showed that increases in hs-CRP, 8-OHdG and fibrinogen, and decreases in HRV indices were associated with increased levels of indoor particles and total VOCs in single-pollutant and two-pollutant models. The effects of indoor particles and total VOCs on cardiovascular endpoints were greatest during visits with the windows open. During visits with the air conditioners turned on, no significant changes in cardiovascular endpoints were observed. In conclusion, indoor air pollution is associated with inflammation, oxidative stress, blood coagulation and autonomic dysfunction. Reductions in indoor air pollution and subsequent improvements in cardiovascular health can be achieved by closing windows and turning on air conditioners at home. Copyright © 2013 Elsevier B.V. All rights reserved.

  6. Accidental strangulation in children by the automatic closing of a car window.

    PubMed

    Serena, Kailene; Piva, Jefferson Pedro; Andreolio, Cinara; Carvalho, Paulo Roberto Antonacci; Rocha, Tais Sica da

    2018-03-01

    Among the main causes of death in our country are car accidents, drowning and accidental burns. Strangulation is a potentially fatal injury and an important cause of homicide and suicide among adults and adolescents. In children, its occurrence is usually accidental. However, in recent years, several cases of accidental strangulation in children around the world have been reported. A 2-year-old male patient was strangled in a car window. The patient was admitted to the pediatric intensive care unit with a Glasgow Coma Scale score of 8 and presented with progressive worsening of respiratory dysfunction and torpor. The patient also presented acute respiratory distress syndrome, acute pulmonary edema and shock. He was managed with protective mechanical ventilation, vasoactive drugs and antibiotic therapy. He was discharged from the intensive care unit without neurological or pulmonary sequelae. After 12 days of hospitalization, he was discharged from the hospital, and his state was very good. The incidence of automobile window strangulation is rare but of high morbidity and mortality due to the resulting choking mechanism. Fortunately, newer cars have devices that stop the automatic closing of the windows if resistance is encountered. However, considering the severity of complications strangulated patients experience, the intensive neuro-ventilatory and hemodynamic management of the pathologies involved is important to reduce morbidity and mortality, as is the need to implement new campaigns for the education of parents and caregivers of children, aiming to avoid easily preventable accidents and to optimize safety mechanisms in cars with electric windows.

  7. The Economic Foundations of Operational Art

    DTIC Science & Technology

    1992-05-20

    War. Prior ti the Industrial Revolution , which happened to coincide closely with the take-off stage, the tools available to the operational artist were...in the age of high mass consumption. "ePowell, R. A. ’Microelectronics.’ Windows on a New World: The Third Industrial Revolution . Joseph Finkelstein...Finkelstein, Joseph, Window on a New World, The Third Industrial Revolution . Nw YorK: Greenwood Press, 1989. Haythornthwaite, Philip J., Napoleon’s

  8. Closeup view of the exterior of the starboard side of ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Close-up view of the exterior of the starboard side of the forward fuselage of the Orbiter Discovery looking at the forward facing observation windows of the flight deck. Note the High-temperature Reusable Surface Insulation (HRSI) surrounding the window openings, the Low-temperature Reusable Surface Insulation (LRSI) immediately beyond the HRSI tiles and the Advanced Flexible Reusable Surface Insulation blankets just beyond the LRSI tiles. The holes in the tiles are injection points for the application of waterproofing material. The windows are composed of redundant pressure window panes of thermal glass. This image was taken from a service platform in the Orbiter Processing Facility at Kennedy Space Center - Space Transportation System, Orbiter Discovery (OV-103), Lyndon B. Johnson Space Center, 2101 NASA Parkway, Houston, Harris County, TX

  9. Hook Region Represented in a Cochlear Model

    NASA Astrophysics Data System (ADS)

    Steele, Charles R.; Kim, Namkeun; Puria, Sunil

    2009-02-01

    The present interest is in discontinuities. Particularly the geometry of the hook region, with the flexible round window nearly parallel with the basilar membrane, is not represented by a standard box model, in which both stapes and round window are placed at the end. A better model represents the round window by a soft membrane in the wall of scala tympani, with the end closed. This complicates the analysis considerably. Features are that the significant compression wave, i.e., the fast wave, is of negligible magnitude in this region, and that significant evanescent waves occur because of the discontinuities at the beginning and end of the simulated round window. The effect of this on both high frequency, with maximum basilar membrane response in the hook region, and lower frequencies are determined.

  10. Temporal and geographical external validation study and extension of the Mayo Clinic prediction model to predict eGFR in the younger population of Swiss ADPKD patients.

    PubMed

    Girardat-Rotar, Laura; Braun, Julia; Puhan, Milo A; Abraham, Alison G; Serra, Andreas L

    2017-07-17

    Prediction models in autosomal dominant polycystic kidney disease (ADPKD) are useful in clinical settings to identify patients with greater risk of a rapid disease progression in whom a treatment may have more benefits than harms. Mayo Clinic investigators developed a risk prediction tool for ADPKD patients using a single kidney value. Our aim was to perform an independent geographical and temporal external validation as well as evaluate the potential for improving the predictive performance by including additional information on total kidney volume. We used data from the on-going Swiss ADPKD study from 2006 to 2016. The main analysis included a sample size of 214 patients with Typical ADPKD (Class 1). We evaluated the Mayo Clinic model performance calibration and discrimination in our external sample and assessed whether predictive performance could be improved through the addition of subsequent kidney volume measurements beyond the baseline assessment. The calibration of both versions of the Mayo Clinic prediction model using continuous Height adjusted total kidney volume (HtTKV) and using risk subclasses was good, with R 2 of 78% and 70%, respectively. Accuracy was also good with 91.5% and 88.7% of the predicted within 30% of the observed, respectively. Additional information regarding kidney volume did not substantially improve the model performance. The Mayo Clinic prediction models are generalizable to other clinical settings and provide an accurate tool based on available predictors to identify patients at high risk for rapid disease progression.

  11. Mayo's Older American Normative Studies: Separate Norms for WMS-R Logical Memory Stories.

    ERIC Educational Resources Information Center

    Smith, Glenn E.; Wong, Jennifer S.; Ivnik, Robert J.; Malec, James F.

    1997-01-01

    Norms are presented for persons ages 56 to 93 years for each story from the Logical Memory subtests of the revised edition of the Wechsler Memory Scale following the methods used for other Mayo's Older American Normative Studies. Means and standard deviations are presented for 3-year interval age groups from age 61 to 88. (SLD)

  12. The use of epilithic Antarctic lichens (Usnea aurantiacoatra and U. antartica) to determine deposition patterns of heavy metals in the Shetland Islands, Antarctica.

    PubMed

    Poblet, A; Andrade, S; Scagliola, M; Vodopivez, C; Curtosi, A; Pucci, A; Marcovecchio, J

    1997-11-27

    Trace-metal contents were recorded for the epilithic antarctic lichens Usnea aurantiacoatra and U. antartica, sampled close to the Argentine scientific station 'Jubany' on '25 de Mayo' (King George) Island, in the Southern Shetland Archipelago (Antarctica). The corresponding heavy-metal levels have been measured through atomic absorption spectrophotometry, following internationally accepted analytical methods. The results obtained support the hypothesis that an atmospheric circulation of trace metals exists on the assessed area, and the activities developed at the different scientific stations located on this island would be a potential source of heavy metals to the evaluated environment. The geographical distribution of trace metals atmospherically transported in the area close to 'Jubany Station' was studied through the corresponding metal contents of the assessed lichens. Finally, the suitability of both analyzed lichen species, Usnea aurantiacoatra and U. antartica, as biological indicators for quantitative monitoring of airborne metals for this antarctic environment was recognized.

  13. Synthesis of optically clear polymeric materials for high temperature windows. [preparation of phenolphthalein polycarbonate resin

    NASA Technical Reports Server (NTRS)

    Pannell, C. E.; Magner, J. E.

    1973-01-01

    A polymer has been developed that has excellent potential for use as windows in spacecraft as well as conventional aircraft. This polymer, phenolphthalein polycarbonate, has outstanding thermal properties, e.g., in place of melting or burning, it produces an insulating charred foam that closes off transmission of radiant heat through the window. This fact, coupled with an oxygen index of 0.43 and a 177 C tensile strength of 58 mega Newtons/sq m, makes this polymer a prime candidate for further development. Pilot plant preparation in a 20 gallon Pfaudler kettle was accomplished and large test specimens were prepared for evaluations.

  14. 24 CFR 3285.801 - Exterior close-up.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... close-up strips/trim must be fastened securely and sealed with exterior sealant (see figure A to this... rear end walls. 2. The manufacturer must install doors/windows trimmed with J-rail or the equivalent... transport. Siding, starter trim, and vents may be shipped loose in the home for installation on set-up. 3...

  15. Finding Frequent Closed Itemsets in Sliding Window in Linear Time

    NASA Astrophysics Data System (ADS)

    Chen, Junbo; Zhou, Bo; Chen, Lu; Wang, Xinyu; Ding, Yiqun

    One of the most well-studied problems in data mining is computing the collection of frequent itemsets in large transactional databases. Since the introduction of the famous Apriori algorithm [14], many others have been proposed to find the frequent itemsets. Among such algorithms, the approach of mining closed itemsets has raised much interest in data mining community. The algorithms taking this approach include TITANIC [8], CLOSET+[6], DCI-Closed [4], FCI-Stream [3], GC-Tree [15], TGC-Tree [16] etc. Among these algorithms, FCI-Stream, GC-Tree and TGC-Tree are online algorithms work under sliding window environments. By the performance evaluation in [16], GC-Tree [15] is the fastest one. In this paper, an improved algorithm based on GC-Tree is proposed, the computational complexity of which is proved to be a linear combination of the average transaction size and the average closed itemset size. The algorithm is based on the essential theorem presented in Sect. 4.2. Empirically, the new algorithm is several orders of magnitude faster than the state of art algorithm, GC-Tree.

  16. MULTICHANNEL ANALYZER

    DOEpatents

    Kelley, G.G.

    1959-11-10

    A multichannel pulse analyzer having several window amplifiers, each amplifier serving one group of channels, with a single fast pulse-lengthener and a single novel interrogation circuit serving all channels is described. A pulse followed too closely timewise by another pulse is disregarded by the interrogation circuit to prevent errors due to pulse pileup. The window amplifiers are connected to the pulse lengthener output, rather than the linear amplifier output, so need not have the fast response characteristic formerly required.

  17. The Mayo Clinic Value Creation System.

    PubMed

    Swensen, Stephen J; Dilling, James A; Harper, C Michel; Noseworthy, John H

    2012-01-01

    The authors present Mayo Clinic's Value Creation System, a coherent systems engineering approach to delivering a single high-value practice. There are 4 tightly linked, interdependent phases of the system: alignment, discovery, managed diffusion, and measurement. The methodology is described and examples of the results to date are presented. The Value Creation System has been demonstrated to improve the quality of patient care while reducing costs and increasing productivity.

  18. Validation of the Mayo Clinic Staging System in Determining Prognoses of Patients With Perihilar Cholangiocarcinoma.

    PubMed

    Coelen, Robert J S; Gaspersz, Marcia P; Labeur, Tim A; van Vugt, Jeroen L A; van Dieren, Susan; Willemssen, François E J A; Nio, Chung Y; IJzermans, Jan N M; Klümpen, Heinz-Josef; Groot Koerkamp, Bas; van Gulik, Thomas M

    2017-12-01

    Most systems for staging perihilar cholangiocarcinoma (PHC) have been developed for the minority of patients with resectable disease. The recently developed Mayo Clinic system for staging PHC requires only clinical and radiologic variables, but has not yet been validated. We performed a retrospective study to validate the Mayo Clinic staging system. We identified consecutive patients with suspected PHC who were evaluated and treated at 2 tertiary centers in The Netherlands, from January 2002 through December 2014. Baseline characteristics (performance status, carbohydrate antigen 19-9 level) used in the staging system were collected from medical records and imaging parameters (tumor size, suspected vascular involvement, and metastatic disease) were reassessed by 2 experienced abdominal radiologists. Overall survival was analyzed using the Kaplan-Meier method and comparison of staging groups was performed using the log-rank test and Cox proportional hazard regression analysis. Discriminative performance was quantified by the concordance index and compared with the radiologic TNM staging of the American Joint Committee on Cancer (7th ed). PHCs from 600 patients were staged according to the Mayo Clinic model (23 stage I, 80 stage II, 357 stage III, and 140 stage IV). The median overall survival time was 11.6 months. The median overall survival times for patients with stages I, II, III, and IV were 33.2 months, 19.7 months, 12.1 months, and 6.0 months, respectively; with hazard ratios of 1.0 (reference), 2.02 (95% confidence interval [CI], 1.14-3.58), 2.71 (95% CI, 1.59-4.64), and 4.00 (95% CI, 2.30-6.95), respectively (P < .001). The concordance index score was 0.59 for the entire cohort (95% CI, 0.56-0.61). The Mayo Clinic model performed slightly better than the radiologic American Joint Committee on Cancer TNM system. In a retrospective study of 600 patients with PHC, we validated the Mayo Clinic system for staging PHC. This 4-tier staging system may aid clinicians in making treatment decisions, such as referral for surgery, and predicting survival times. Copyright © 2017 AGA Institute. Published by Elsevier Inc. All rights reserved.

  19. Simplified Computation for Nonparametric Windows Method of Probability Density Function Estimation.

    PubMed

    Joshi, Niranjan; Kadir, Timor; Brady, Michael

    2011-08-01

    Recently, Kadir and Brady proposed a method for estimating probability density functions (PDFs) for digital signals which they call the Nonparametric (NP) Windows method. The method involves constructing a continuous space representation of the discrete space and sampled signal by using a suitable interpolation method. NP Windows requires only a small number of observed signal samples to estimate the PDF and is completely data driven. In this short paper, we first develop analytical formulae to obtain the NP Windows PDF estimates for 1D, 2D, and 3D signals, for different interpolation methods. We then show that the original procedure to calculate the PDF estimate can be significantly simplified and made computationally more efficient by a judicious choice of the frame of reference. We have also outlined specific algorithmic details of the procedures enabling quick implementation. Our reformulation of the original concept has directly demonstrated a close link between the NP Windows method and the Kernel Density Estimator.

  20. Additive Manufacturing for Highly Efficient Window Inserts CRADA Report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Roschli, Alex C.; Chesser, Phillip C.; Love, Lonnie J.

    ORNL partnered with the Mackinac Technology Company to demonstrate how additive manufacturing can be used to create highly energy efficient window inserts for retrofit in pre-existing buildings. Many early iterations of the window inserts were fabricated using carbon fiber reinforced thermoplastics and polycarbonate films as a stand in for the low-e coated films produced by the Mackinac Technology Company. After demonstration of the proof of concept, i.e. custom window inserts with tensioned film, the materials used for the manufacture of the frames was more closely examined. Hollow particle-filled syntactic foam and low-density polymer composites formed by expandable microspheres were exploredmore » as the materials used to additively manufacture the frames of the inserts. It was concluded that low-cost retrofit window inserts in custom sizes could be easily fabricated using large scale additive manufacturing. Furthermore, the syntactic and expanded foams developed and tested satisfy the mechanical performance requirements for the application.« less

  1. Use of Echocardiography in Olmsted County Outpatients With Chest Pain and Normal Resting Electrocardiograms Seen at Mayo Clinic Rochester.

    PubMed

    Gibbons, Raymond J; Carryer, Damita; Liu, Hongfang; Brady, Peter A; Askew, J Wells; Hodge, David; Ammash, Naser; Ebbert, Jon O; Roger, Veronique L

    2015-11-01

    To determine how often unnecessary resting echocardiograms that are "not recommended" by clinical practice guidelines are performed in patients with stable chest pain and normal resting electrocardiograms (ECGs). We performed a retrospective search of electronic medical records of all outpatients seen at Mayo Clinic Rochester from January 1, 2010, through December 31, 2013, to identify residents of Olmsted County, Minnesota, with stable chest pain and known or suspected coronary artery disease who underwent resting echocardiography and had normal resting ECGs and no other indication for echocardiography. Of the 8280 outpatients from Olmsted County who were evaluated at Mayo Clinic Rochester with chest pain, 590 (7.1%) had resting echocardiograms. Ninety-two of these 590 patients (15.6%) had normal resting ECGs. Thirty-three of these 92 patients (35.9%) had other indications for echocardiography. The remaining 59 patients (10.0% of all echocardiograms and 0.7% of all patients) had normal resting ECGs and no other indication for echocardiography. Fifty-seven of these 59 patients (96.6%) had normal echocardiograms. Thirteen of these 59 echocardiograms (22.0%) were "preordered" before the provider (physicians, nurses, physician assistants) visit. The overall rate of echocardiography in Olmsted County outpatients with chest pain seen at Mayo Clinic Rochester is low. Only 1 in 10 of these echocardiograms was performed in violation of the class III recommendation in the American College of Cardiology Foundation/American Heart Association guidelines for the management of stable angina. These unnecessary echocardiograms were almost always normal. The rate of unnecessary echocardiograms could be decreased by eliminating preordering. Copyright © 2015 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc. All rights reserved.

  2. Small median tumor diameter at cure threshold (<20 mm) among aggressive non-small cell lung cancers in male smokers predicts both chest X-ray and CT screening outcomes in a novel simulation framework.

    PubMed

    Goldwasser, Deborah L; Kimmel, Marek

    2013-01-01

    The effectiveness of population-wide lung cancer screening strategies depends on the underlying natural course of lung cancer. We evaluate the expected stage distribution in the Mayo CT screening study under an existing simulation model of non-small cell lung cancer (NSCLC) progression calibrated to the Mayo lung project (MLP). Within a likelihood framework, we evaluate whether the probability of 5-year NSCLC survival conditional on tumor diameter at detection depends significantly on screening detection modality, namely chest X-ray and computed tomography. We describe a novel simulation framework in which tumor progression depends on cellular proliferation and mutation within a stem cell compartment of the tumor. We fit this model to randomized trial data from the MLP and produce estimates of the median radiologic size at the cure threshold. We examine the goodness of model fit with respect to radiologic tumor size and 5-year NSCLC survival among incident cancers in both the MLP and Mayo CT studies. An existing model of NSCLC progression under-predicts the number of advanced-stage incident NSCLCs among males in the Mayo CT study (p-value = 0.004). The probability of 5-year NSCLC survival conditional on tumor diameter depends significantly on detection modality (p-value = 0.0312). In our new model, selected solution sets having a median tumor diameter of 16.2-22.1 mm at cure threshold among aggressive NSCLCs predict both MLP and Mayo CT outcomes. We conclude that the median lung tumor diameter at cure threshold among aggressive NSCLCs in male smokers may be small (<20 mm). Copyright © 2012 UICC.

  3. Use of the"bogota bag"for closure of open abdominal wound after exploratory laparotomy - our experience at Mayo Hospital Lahore.

    PubMed

    Muhammad, Yar; Gondal, Khalid Masood; Khan, Umair Ahmed

    2016-08-01

    To assess the efficacy of Bogota bag for closure of open abdominal wounds after laparotomy where the primary closure cannot be achieved and other closure techniques are not available. The descriptive study was conducted at Mayo Hospital, Lahore, Pakistan, from September 2011 to February2015, and comprised patients who underwent laparotomy and peritoneal cavities and who could not be closed primarily because of various reasons like traumatic loss and oedematous gut. They were managed with Bogota bag for abdominal closure. SPSS 18 was used for statistical analysis. Of the 55 patients, 37(67.27%) were male and 18(32.73%) were female. There was traumatic loss in 34(61.8%), oedematous gut and omentum in 15(27.27%) and gangrenous abdominal wall in 6(10.9%) patients. Bogota bag was applied in all (100%) of them. In 19(34.55%) patients, delayed primary closure was possible, so the Bogota was used temporarily. In 36(65.45%) cases managed with Bogota bag, healing occurred by granulation tissue or skin grafting/flaps were applied and these patients developed hernia. Five (9.09%) patients developed small bowel fistula which was managed conservatively. No patient developed complication due to exposure or abdominal compartment. There were 7(12.8%) postoperative deaths due to the disease process and were unrelated to the closure technique. Bogota bag was an effective means of closure of open abdominal wound and prevented the complications due to open abdominal wounds or closure under tension.

  4. Dr Albert L. Rhoton Jr's Time at the Mayo Clinic: The Beginnings of a Remarkable Career.

    PubMed

    Rayan, Tarek; Carlson, Matthew L; Piepgras, David G; Link, Michael J; Van Gompel, Jamie J

    2017-08-09

    Dr Albert L. Rhoton Jr became the focal point of neurosurgery's evolution in understanding the intricate and complex microanatomy of the human brain over the last 4 decades. His pioneering work on cadaveric specimens proved to be a pivotal endeavor in the pursuit to better understand the complex microsurgical anatomy of cranial surgery. This paper details his early career at the Mayo Clinic in Rochester, Minnesota. A comprehensive review and synthesis of data acquired from the institutional historical archives including the Annual Reports to the Executive Committee, the Reports to the Board of Directors, the MAYOVOX Newsletter, the illustration archives of the Mayo Clinic Division of Creative Media, staff biographies, curriculum vitae, personal interviews, as well as full-text journal articles, and book publications was performed. Dr Rhoton was engaged in a busy clinical practice as a young staff at the Mayo Clinic. Records show he focused on tackling complex intracranial pathologies along with numerous basic research and neuroanatomy projects that became a major part of his life's work and passion. He was a great teacher and friend to countless individuals and his work will continue to impact and improve the care provided to neurosurgery patients for generations to come. Copyright © 2017 by the Congress of Neurological Surgeons.

  5. Physical properties of extruded products from three Mexican common beans (Phaseolus vulgaris L.) cultivars.

    PubMed

    Rocha-Guzman, N E; Gallegos-Infante, J A; Gonzalez-Laredo, R F; Bello-Perez, A; Delgado-Licon, E; Ochoa-Martinez, A; Prado-Ortiz, M J

    2008-09-01

    The physical properties of extruded products from three Mexican common bean cultivars were investigated. Common bean cultivars Flor de Mayo, Pinto Villa and Bayo Victoria from the same harvesting season (2006) were used in this work. Beans were milled and the flour was hydrated to 24, 26 and 28 g of water/100 g of dry weight. Two temperatures, 130 degrees C and 165 degrees C at the end of the extruder barrel without die, were experimented. Common bean flour extrudates were evaluated for water absorption index (WAI), water absorption capacity (WAC), oil absorption capacity (OAC), and emulsifying capacity (EC). Flor de Mayo extrudates showed the highest WAC and WAI values. Thus starch from Flor de Mayo beans showed minor restricted water availability. In all cases, the OAC of extruded products was lower than the crude bean flour. The EC for Bayo Victoria flour increased as a consequence of the extrusion process. The EC for Flor de Mayo was higher at lower temperature and lower moisture content than Pinto Villa and Bayo Victoria beans. EC behavior of Pinto Villa was similar to Bayo cultivar. These results indicate that it is possible to produce new extruded products with good physical properties from these common bean cultivars.

  6. Development of the Mayo Investigational Neuromodulation Control System: toward a closed-loop electrochemical feedback system for deep brain stimulation

    PubMed Central

    Chang, Su-Youne; Kimble, Christopher J.; Kim, Inyong; Paek, Seungleal B.; Kressin, Kenneth R.; Boesche, Joshua B.; Whitlock, Sidney V.; Eaker, Diane R.; Kasasbeh, Aimen; Horne, April E.; Blaha, Charles D.; Bennet, Kevin E.; Lee, Kendall H.

    2014-01-01

    Object Conventional deep brain stimulation (DBS) devices continue to rely on an open-loop system in which stimulation is independent of functional neural feedback. The authors previously proposed that as the foundation of a DBS “smart” device, a closed-loop system based on neurochemical feedback, may have the potential to improve therapeutic outcomes. Alterations in neurochemical release are thought to be linked to the clinical benefit of DBS, and fast-scan cyclic voltammetry (FSCV) has been shown to be effective for recording these evoked neurochemical changes. However, the combination of FSCV with conventional DBS devices interferes with the recording and identification of the evoked analytes. To integrate neurochemical recording with neurostimulation, the authors developed the Mayo Investigational Neuromodulation Control System (MINCS), a novel, wirelessly controlled stimulation device designed to interface with FSCV performed by their previously described Wireless Instantaneous Neurochemical Concentration Sensing System (WINCS). Methods To test the functionality of these integrated devices, various frequencies of electrical stimulation were applied by MINCS to the medial forebrain bundle of the anesthetized rat, and striatal dopamine release was recorded by WINCS. The parameters for FSCV in the present study consisted of a pyramidal voltage waveform applied to the carbon-fiber microelectrode every 100 msec, ramping between −0.4 V and +1.5 V with respect to an Ag/AgCl reference electrode at a scan rate of either 400 V/sec or 1000 V/sec. The carbon-fiber microelectrode was held at the baseline potential of −0.4 V between scans. Results By using MINCS in conjunction with WINCS coordinated through an optic fiber, the authors interleaved intervals of electrical stimulation with FSCV scans and thus obtained artifact-free wireless FSCV recordings. Electrical stimulation of the medial forebrain bundle in the anesthetized rat by MINCS elicited striatal dopamine release that was time-locked to stimulation and increased progressively with stimulation frequency. Conclusions Here, the authors report a series of proof-of-principle tests in the rat brain demonstrating MINCS to be a reliable and flexible stimulation device that, when used in conjunction with WINCS, performs wirelessly controlled stimulation concurrent with artifact-free neurochemical recording. These findings suggest that the integration of neurochemical recording with neurostimulation may be a useful first step toward the development of a closed-loop DBS system for human application. PMID:24116724

  7. Surgical anatomy of the round window-Implications for cochlear implantation.

    PubMed

    Luers, J C; Hüttenbrink, K B; Beutner, D

    2018-04-01

    The round window is an important portal for the application of active hearing aids and cochlear implants. The anatomical and topographical knowledge about the round window region is a prerequisite for successful insertion for a cochlear implant electrode. To sum up current knowledge about the round window anatomy and to give advice to the cochlear implant surgeon for optimal placement of an electrode. Systematic Medline search. Search term "round window[Title]" with no date restriction. Only publications in the English Language were included. All abstracts were screened for relevance, that is a focus on surgical anatomy of the round window. The search results were supplemented with hand searching of selected reviews and reference lists from included studies. Subjective assessment. There is substantial variability in size and shape of the round window. The round window is regarded as the most reliable surgical landmark to safely locate the scala tympani. Factors affecting the optimal trajectory line for atraumatic electrode insertion are anatomy of the round window, the anatomy of the intracochlear hook region and the variable orientation and size of the cochlea's basal turn. The very close relation to the sensitive inner ear structures necessitates a thorough anatomic knowledge and careful insertion technique, especially when implanting patients with residual hearing. In order to avoid electrode migration between the scalae and to achieve protect the modiolus and the basilar membrane, it is recommended to aim for an electrode insertion vector from postero-superior to antero-inferior. © 2017 John Wiley & Sons Ltd.

  8. Design and RF measurements of a 5 GHz 500 kW window for the ITER LHCD system

    NASA Astrophysics Data System (ADS)

    Hillairet, J.; Achard, J.; Bae, Y. S.; Bernard, J. M.; Dechambre, N.; Delpech, L.; Ekedahl, A.; Faure, N.; Goniche, M.; Kim, J.; Larroque, S.; Magne, R.; Marfisi, L.; Namkung, W.; Park, H.; Park, S.; Poli, S.; Vulliez, K.

    2014-02-01

    CEA/IRFM is conducting R&D efforts in order to validate the critical RF components of the 5 GHz ITER LHCD system, which is expected to transmit 20 MW of RF power to the plasma. Two 5 GHz 500 kW BeO pill-box type window prototypes have been manufactured in 2012 by the PMB Company, in close collaboration with CEA/IRFM. Both windows have been validated at low power, showing good agreement between measured and modeling, with a return loss better than 32 dB and an insertion loss below 0.05 dB. This paper reports on the window RF design and the low power measurements. The high power tests up to 500kW have been carried out in March 2013 in collaboration with NFRI. Results of these tests are also reported.

  9. Large-scale building scenes reconstruction from close-range images based on line and plane feature

    NASA Astrophysics Data System (ADS)

    Ding, Yi; Zhang, Jianqing

    2007-11-01

    Automatic generate 3D models of buildings and other man-made structures from images has become a topic of increasing importance, those models may be in applications such as virtual reality, entertainment industry and urban planning. In this paper we address the main problems and available solution for the generation of 3D models from terrestrial images. We first generate a coarse planar model of the principal scene planes and then reconstruct windows to refine the building models. There are several points of novelty: first we reconstruct the coarse wire frame model use the line segments matching with epipolar geometry constraint; Secondly, we detect the position of all windows in the image and reconstruct the windows by established corner points correspondences between images, then add the windows to the coarse model to refine the building models. The strategy is illustrated on image triple of college building.

  10. Remembering Joseph Mayo and His Contributions to Animal Science | Poster

    Cancer.gov

    By Carolynne Keenan, Guest Writer In the 1990s, when Joseph Mayo, D.V.M, ran out of gas leading coworkers home from a meeting in Bethesda, he pulled over to the side of the road on I-270 and waited for help. He didn’t have to wait long; within a few minutes a passing motorist took pity on the group of scientists and offered them a lift back to Fort Detrick.

  11. Mayo Clinic Zebrafish Facility Overview.

    PubMed

    Leveque, Ryan E; Clark, Karl J; Ekker, Stephen C

    2016-07-01

    The zebrafish (Danio rerio) is a premier nonmammalian vertebrate model organism. This small aquatic fish is utilized in multiple disciplines in the Mayo Clinic community and by many laboratories around the world because of its biological similarity to humans, its advanced molecular genetics, the elucidation of its genome sequence, and the ever-expanding and outstanding new biological tools now available to the zebrafish researcher. The Mayo Clinic Zebrafish Facility (MCZF) houses ∼2,000 tanks annotated using an in-house, Internet cloud-based bar-coding system tied to our established zfishbook.org web infrastructure. Paramecia are the primary food source for larval fish rearing, using a simplified culture protocol described herein. The MCZF supports the specific ongoing research in a variety of laboratories, while also serving as a local hub for new scientists as they learn to tap into the potential of this model system for understanding normal development, disease, and as models of health.

  12. NATO Planning Guide for the Estimation of CBRN Casualties

    DTIC Science & Technology

    2014-11-01

    for CBRN Defense ( J -8, JRO). The publication of this IDA document does not indicate endorsement by the Department of Defense, nor should the...Vehicle - Closed Windows 4.2 MTR, ACE, CHAPP, 36 M106 A2 4.2, M113 Stationary Vehicle - Open Windows, TruckNan 40 Fan on Fresh Air * Adapted from J ...5. CFHD= ECt50-severe(HD/PC/V) ED50-severe(HD/PC/L) , (4-5) where: 47 Gene E. McClellan, George H. Anno , and Leigh N. Matheson, Consequence

  13. Demand-type gas supply system for rocket borne thin-window proportional counters

    NASA Technical Reports Server (NTRS)

    Acton, L. W.; Caravalho, R.; Catura, R. C.; Joki, E. G.

    1977-01-01

    A simple closed loop control system has been developed to maintain the gas pressure in thin-window proportional counters during rocket flights. This system permits convenient external control of detector pressure and system flushing rate. The control system is activated at launch with the sealing of a reference volume at the existing system pressure. Inflight control to plus or minus 2 torr at a working pressure of 760 torr has been achieved on six rocket flights.

  14. Investigating the Naval Logistics Role in Humanitarian Assistance Activities

    DTIC Science & Technology

    2015-03-01

    transportation means. E. BASE CASE RESULTS The computations were executed on a MacBook Pro , 3 GHz Intel Core i7-4578U processor with 8 GB. The...MacBook Pro was partitioned to also contain a Windows 7, 64-bit operating system. The computations were run in the Windows 7 operating system using the...it impacts the types of metamodels that can be developed as a result of data farming (Lucas et al., 2015). Using a metamodel, one can closely

  15. VIEW OF DINING ROOM WITH SLIDING DOORS IN CLOSED POSITION. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW OF DINING ROOM WITH SLIDING DOORS IN CLOSED POSITION. WINDOWS ON THE LEFT HAND SIDE HAVE VIEWS INTO THE CARPORT. VIEW FACING NORTH - Camp H.M. Smith and Navy Public Works Center Manana Title VII (Capehart) Housing, Three-Bedroom Single-Family Type 9, Birch Circle, Elm Drive, Elm Circle, and Date Drive, Pearl City, Honolulu County, HI

  16. Microwave window breakdown experiments and simulations on the UM/L-3 relativistic magnetron

    NASA Astrophysics Data System (ADS)

    Hoff, B. W.; Mardahl, P. J.; Gilgenbach, R. M.; Haworth, M. D.; French, D. M.; Lau, Y. Y.; Franzi, M.

    2009-09-01

    Experiments have been performed on the UM/L-3 (6-vane, L-band) relativistic magnetron to test a new microwave window configuration designed to limit vacuum side breakdown. In the baseline case, acrylic microwave windows were mounted between three of the waveguide coupling cavities in the anode block vacuum housing and the output waveguides. Each of the six 3 cm deep coupling cavities is separated from its corresponding anode cavity by a 1.75 cm wide aperture. In the baseline case, vacuum side window breakdown was observed to initiate at single waveguide output powers close to 20 MW. In the new window configuration, three Air Force Research Laboratory-designed, vacuum-rated directional coupler waveguide segments were mounted between the coupling cavities and the microwave windows. The inclusion of the vacuum side power couplers moved the microwave windows an additional 30 cm away from the anode apertures. Additionally, the Lucite microwave windows were replaced with polycarbonate windows and the microwave window mounts were redesigned to better maintain waveguide continuity in the region around the microwave windows. No vacuum side window breakdown was observed in the new window configuration at single waveguide output powers of 120+MW (a factor of 3 increase in measured microwave pulse duration and factor of 3 increase in measured peak power over the baseline case). Simulations were performed to investigate likely causes for the window breakdown in the original configuration. Results from these simulations have shown that in the original configuration, at typical operating voltage and magnetic field ranges, electrons emitted from the anode block microwave apertures strike the windows with a mean kinetic energy of 33 keV with a standard deviation of 14 keV. Calculations performed using electron impact angle and energy data predict a first generation secondary electron yield of 65% of the primary electron population. The effects of the primary aperture electron impacts, combined with multiplication of the secondary populations, were determined to be the likely causes of the poor microwave window performance in the original configuration.

  17. Characterisation of nanoparticle emissions and exposure at traffic intersections through fast-response mobile and sequential measurements

    NASA Astrophysics Data System (ADS)

    Goel, Anju; Kumar, Prashant

    2015-04-01

    Quantification of disproportionate contribution made by signalised traffic intersections (TIs) to overall daily commuting exposure is important but barely known. We carried out mobile measurements in a car for size-resolved particle number concentrations (PNCs) in the 5-560 nm range under five different ventilation settings on a 6 km long busy round route with 10 TIs. These ventilation settings were windows fully open and both outdoor air intake from fan and heating off (Set1), windows closed, fan 25% on and heating 50% on (Set2), windows closed, fan 100% on and heating off (Set3), windows closed, fan off and heating 100% on (Set4), and windows closed, fan and heating off (Set5). Measurements were taken sequentially inside and outside the car cabin at 10 Hz sampling rate using a solenoid switching system in conjunction with a fast response differential mobility spectrometer (DMS50). The objectives were to: (i) identify traffic conditions under which TIs becomes hot-spots of PNCs, (ii) assess the effect of ventilation settings in free-flow and delay conditions (waiting time at a TI when traffic signal is red) on in-cabin PNCs with respect to on-road PNCs at TIs, (iii) deriving the relationship between the PNCs and change in driving speed during delay time at the TIs, and (iv) quantify the contribution of exposure at TIs with respect to overall commuting exposure. Congested TIs were found to become hot-spots when vehicle accelerate from idling conditions. In-cabin peak PNCs followed similar temporal trend as for on-road peak PNCs. Reduction in in-cabin PNC with respect to outside PNC was highest (70%) during free-flow traffic conditions when both fan drawing outdoor air into the cabin and heating was switched off. Such a reduction in in-cabin PNCs at TIs was highest (88%) with respect to outside PNC during delay conditions when fan was drawing outside air at 25% on and heating was 50% on settings. PNCs and change in driving speed showed an exponential-fit relationship during the delay events at TIs. Short-term exposure for ∼2% of total commuting time in car corresponded to ∼25% of total respiratory doses. This study highlights a need for more studies covering diverse traffic and geographical conditions in urban environments so that the disparate contribution of exposure at TIs can be quantified.

  18. Current status of the joint Mayo Clinic-IBM PACS project

    NASA Astrophysics Data System (ADS)

    Hangiandreou, Nicholas J.; Williamson, Byrn, Jr.; Gehring, Dale G.; Persons, Kenneth R.; Reardon, Frank J.; Salutz, James R.; Felmlee, Joel P.; Loewen, M. D.; Forbes, Glenn S.

    1994-05-01

    A multi-phase collaboration between Mayo Clinic and IBM-Rochester was undertaken, with the goal of developing a picture archiving and communication system for routine clinical use in the Radiology Department. The initial phase of this project (phase 0) was started in 1988. The current system has been fully integrated into the clinical practice and, to date, over 6.5 million images from 16 imaging modalities have been archived. Phase 3 of this project has recently concluded.

  19. The Hand That Gives the Rose

    PubMed Central

    Pawlina, Wojciech; Hammer, Rachel R.; Strauss, Jeffrey D.; Heath, Shaun G.; Zhao, Kristin D.; Sahota, Shawn; Regnier, Terry D.; Freshwater, Dawn R.; Feeley, Mary A.

    2011-01-01

    “Convocation of Thanks” is the annual ceremony commemorating the gift of body donation to the Mayo Clinic Bequest program in the Department of Anatomy, College of Medicine, Mayo Clinic in Rochester, MN. For 26 years, this ceremony of gratitude has given students, researchers, faculty, and family members an opportunity to reflect on the immeasurable value of these gifts. The authors describe the significance of ceremonies such as these in historical context and provide abridged transcripts of participants' speeches. PMID:21282487

  20. 3. CLOSEUP OF GARDEN AND NORTH ELEVATIONS, SHOWING PEDIMENTED GABLES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. CLOSE-UP OF GARDEN AND NORTH ELEVATIONS, SHOWING PEDIMENTED GABLES WITH OCULI, WIDOW'S WALK, PEDIMENTED, DOORWAY AND ARCHED WINDOW - Mt. Harmon Plantation at World's End, Earleville, Cecil County, MD

  1. 6. Historic American Buildings Survey Alex Bush, Photographer, October 16, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. Historic American Buildings Survey Alex Bush, Photographer, October 16, 1935 CLOSE-UP OF EXTERIOR VIEW OF TYPICAL PORTICO WINDOW - University of Alabama, President's House, University Boulevard, Tuscaloosa, Tuscaloosa County, AL

  2. Measurement of Temporal Awareness in Air Traffic Control

    NASA Technical Reports Server (NTRS)

    Rantanen, E.M.

    2009-01-01

    Temporal awareness, or level 3 situation awareness, is critical to successful control of air traffic, yet the construct remains ill-defined and difficult to measure. This research sought evidence for air traffic controllers awareness of temporal characteristics of their tasks in data from a high-fidelity system evaluation simulation. Five teams of controllers worked on four scenarios with different traffic load. Several temporal parameters were defined for each task controllers performed during a simulation run and their actions on the tasks were timed relative to them. Controllers showed a strong tendency to prioritize tasks according to a first come, first served principle. This trend persisted as task load increased. Also evident was awareness of the urgency of tasks, as tasks with impending closing of a window of opportunity were performed before tasks that had longer time available before closing of the window.

  3. Mitigating residential exposure to secondhand tobacco smoke

    NASA Astrophysics Data System (ADS)

    Klepeis, Neil E.; Nazaroff, William W.

    In a companion paper, we used a simulation model to explore secondhand tobacco smoke (SHS) exposures for typical conditions in residences. In the current paper, we extend this analysis to evaluate the effectiveness of physical mitigation approaches in reducing nonsmokers' exposure to airborne SHS particulate matter in a hypothetical 6-zone house. Measures investigated included closing doors or opening windows in response to smoking activity, modifying location patterns to segregate the nonsmoker and the active smoker, and operating particle filtration devices. We first performed 24 scripted simulation trials using hypothetical patterns of occupant location. We then performed cohort simulation trials across 25 mitigation scenarios using over 1000 pairs of nonsmoker and smoker time-location patterns that were selected from a survey of human activity patterns in US homes. We limited cohort pairs to cases where more than 10 cigarettes were smoked indoors at home each day and the nonsmoker was at home for more than two thirds of the day. We evaluated the effectiveness of each mitigation approach by examining its impact on the simulated frequency distribution of residential SHS particle exposure. The two most effective strategies were the isolation of the smoker in a closed room with an open window, and a ban on smoking whenever the nonsmoker was at home. The use of open windows to supply local or cross ventilation, or the operation of portable filtration devices in smoking rooms, provided moderate exposure reductions. Closed doors, by themselves, were not effective.

  4. Mechanisms Underlying Decision-Making as Revealed by Deep-Brain Stimulation in Patients with Parkinson's Disease.

    PubMed

    Herz, Damian M; Little, Simon; Pedrosa, David J; Tinkhauser, Gerd; Cheeran, Binith; Foltynie, Tom; Bogacz, Rafal; Brown, Peter

    2018-04-23

    To optimally balance opposing demands of speed and accuracy during decision-making, we must flexibly adapt how much evidence we require before making a choice. Such adjustments in decision thresholds have been linked to the subthalamic nucleus (STN), and therapeutic STN deep-brain stimulation (DBS) has been shown to interfere with this function. Here, we performed continuous as well as closed-loop DBS of the STN while Parkinson's disease patients performed a perceptual decision-making task. Closed-loop STN DBS allowed temporally patterned STN stimulation and simultaneous recordings of STN activity. This revealed that DBS only affected patients' ability to adjust decision thresholds if applied in a specific temporally confined time window during deliberation. Only stimulation in that window diminished the normal slowing of response times that occurred on difficult trials when DBS was turned off. Furthermore, DBS eliminated a relative, time-specific increase in STN beta oscillations and compromised its functional relationship with trial-by-trial adjustments in decision thresholds. Together, these results provide causal evidence that the STN is involved in adjusting decision thresholds in distinct, time-limited processing windows during deliberation. Copyright © 2018 The Authors. Published by Elsevier Ltd.. All rights reserved.

  5. Settling into an increasingly hostile world: the rapidly closing "recruitment window" for corals.

    PubMed

    Arnold, Suzanne N; Steneck, Robert S

    2011-01-01

    Free space is necessary for larval recruitment in all marine benthic communities. Settling corals, with limited energy to invest in competitive interactions, are particularly vulnerable during settlement into well-developed coral reef communities. This situation may be exacerbated for corals settling into coral-depauperate reefs where succession in nursery microhabitats moves rapidly toward heterotrophic organisms inhospitable to settling corals. To study effects of benthic organisms (at millimeter to centimeter scales) on newly settled corals and their survivorship we deployed terra-cotta coral settlement plates at 10 m depth on the Mesoamerican Barrier Reef in Belize and monitored them for 38 mo. During the second and third years, annual recruitment rates declined by over 50% from the previous year. Invertebrate crusts (primarily sponges) were absent at the start of the experiment but increased in abundance annually from 39, 60, to 73% of the plate undersides by year three. Subsequently, substrates hospitable to coral recruitment, including crustose coralline algae, biofilmed terra-cotta and polychaete tubes, declined. With succession, substrates upon which spat settled shifted toward organisms inimical to survivorship. Over 50% of spat mortality was due to overgrowth by sponges alone. This result suggests that when a disturbance creates primary substrate a "recruitment window" for settling corals exists from approximately 9 to 14 mo following the disturbance. During the window, early-succession, facilitating species are most abundant. The window closes as organisms hostile to coral settlement and survivorship overgrow nursery microhabitats.

  6. Importance of eaves to house entry by anopheline, but not culicine, mosquitoes.

    PubMed

    Njie, Mbye; Dilger, Erin; Lindsay, Steven W; Kirby, Matthew J

    2009-05-01

    Screening homes is an effective way of reducing house entry by mosquitoes. Here, we assess how important blocking the eaves is for reducing house entry by anopheline and culicine mosquitoes for houses that have screened doors and no windows. Twelve houses, with two screened doors and no windows, in which a single adult male slept, were included in a simple crossover design. In the first period, six houses were randomly selected and had the eaves blocked using a mixture of rubble and mortar; the other six were left with open eaves. Mosquitoes were sampled using CDC light traps from each house twice a week for 4 wk. Mosquito control activities and the number and type of domestic animals within the compound was recorded on each sampling occasion. Before beginning the second sampling period, homes with blocked eaves had them opened, and those with open eaves had them closed. Mosquitoes were then sampled from each house for a further 4 wk. When houses had their eaves closed, a three-fold reduction in Anopheles gambiae s.l. Giles caught indoors was observed. However, there was no reduction in total culicine numbers observed. This study demonstrates that the eaves are the major route by which An. gambiae enters houses. By contrast, culicine mosquitoes enter largely through doors and windows. Sealing the eave gap is an important method for reducing malaria transmission in homes where doors and windows are screened.

  7. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ojeda-Gonzalez, A.; Prestes, A.; Klausner, V.

    Spatio-temporal entropy (STE) analysis is used as an alternative mathematical tool to identify possible magnetic cloud (MC) candidates. We analyze Interplanetary Magnetic Field (IMF) data using a time interval of only 10 days. We select a convenient data interval of 2500 records moving forward by 200 record steps until the end of the time series. For every data segment, the STE is calculated at each step. During an MC event, the STE reaches values close to zero. This extremely low value of STE is due to MC structure features. However, not all of the magnetic components in MCs have STEmore » values close to zero at the same time. For this reason, we create a standardization index (the so-called Interplanetary Entropy, IE, index). This index is a worthwhile effort to develop new tools to help diagnose ICME structures. The IE was calculated using a time window of one year (1999), and it has a success rate of 70% over other identifiers of MCs. The unsuccessful cases (30%) are caused by small and weak MCs. The results show that the IE methodology identified 9 of 13 MCs, and emitted nine false alarm cases. In 1999, a total of 788 windows of 2500 values existed, meaning that the percentage of false alarms was 1.14%, which can be considered a good result. In addition, four time windows, each of 10 days, are studied, where the IE method was effective in finding MC candidates. As a novel result, two new MCs are identified in these time windows.« less

  8. Forest Resources, Chiefdoms and Mortuary Practices in the Neotropics: Preliminary Archaeobotanical Analysis from El Caño Funerary Complex (Coclé Province, Panamá)

    NASA Astrophysics Data System (ADS)

    Martín Seijo, M.; Torné, J. Mayo; Torné, C. Mayo; Huerta, R. Piqué i.

    2012-04-01

    El Caño site is situated on the Pacific side of Panamá, near the Río Grande. It's a funerary complex comprising different types of structures (stone structures -basalt columns, groups of sculptures and a causeway-; earthen mounds and canals; burials). The excavations supervised by Julia Mayo between 2008 and 2011 allowed to discover several lavish burials estimated to date between 700 and 1000 AD (Mayo & Mayo 2012). The data recovered has served as source of information for the pre-Columbian chiefdoms and their mortuary practices. There was carried out a detailed taphonomic study to register the complex formation processes of these burial deposits, and the significant post-depositional transformations (anthropogenic and natural processes) (Mayo & Mayo in press). Also during the excavations were recovered archaeobotanical samples; most of them charcoals. The laboratory work process consisted in the exhaustive description of the anatomical features of the different taxa identified during the charcoal analyses (the identification level varied from species to family, although in several case we couldn't propose any taxa). These samples were concentrated in structures, and in few cases dispersed in the sediment. Some of the samples analyzed were large pieces of charcoal of the wooden beams from ancient wood structures, and other pieces of charcoal and vegetable fibers were related directly with the burial practices. The charcoal analysis results aim to contribute to the knowledge of the exploitation of forest resources, of the territories where these resources were collected, and of the production process (chaîne opératoire). These results were complemented with the exhaustive review of written sources (spanish chronicles), ethnobotanical studies and archaeological data of other sites in this area. Acknowledgements: This research was developed under El Caño Archaeological Project and was funded by SENACYT (Secretaría Nacional de Ciencia y Tecnología de Panamá).

  9. 34. CLOSE VIEW OF THE WEST ELEVATION, LOOKING TO THE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    34. CLOSE VIEW OF THE WEST ELEVATION, LOOKING TO THE SOUTHWEST CORNER WHERE THE TOWER JOINS THE WEST GABLE & THE BRICK STEPS LEAD UP TO A SMALL VERANDAH ON THE SOUTH (NOTE: BROWNSTONE THRESHOLD, ARCHED OPENING WITH BROWNSTONE DETAILS THAT ENDS AT THE MOLDED STRINGCOURSE AND SMALLER WINDOW INSIDE THIS ARCHED OPENING) - Kenworthy Hall, State Highway 14 (Greensboro Road), Marion, Perry County, AL

  10. VLSI Research

    DTIC Science & Technology

    1984-04-01

    Ousterhout, G.T. Hamachi, R.N. Mayo, W.S. Scott, and G.S. Taylor , "A Collection of Papers on Magic," Technical Report No. UCB/CSD 83/154, Computer Science...Division, University of California, Berkeley, December 1983. (3) J.K Ousterhout, G.T. Hamachi, R.N. Mayo, W.S. Scott, and G.S. Taylor , "Magic: A...VLSI Layout System." to appear, Slst Design Automation Confer- ence, June 1984. (4) G.S. Taylor and J.K Ousterhout, "Magic’s Incremental Design-Rule

  11. Medical device innovation and the value analysis process.

    PubMed

    Krantz, Heidi; Strain, Barbara; Torzewski, Jane

    2017-09-01

    Heidi A. Krantz, RN, BSN is the Director of Value Analysis at Johns Hopkins Bayview Medical Center in the Johns Hopkins Health System. Barbara Strain, MA, CVAHP is the Director of Value Management at the University of Virginia Health System. Jane Torzewski RN, MAN, MBA is a Senior Category Manager for the Mayo Clinic Physician Preference Contracting team. She previously was a Senior Clinical Value Analyst on the Mayo Clinic Value Analysis team. Copyright © 2018. Published by Elsevier Inc.

  12. Mayo Clinic Jacksonville electronic radiology practice

    NASA Astrophysics Data System (ADS)

    Morin, Richard L.; Berquist, Thomas H.; Rueger, Wolfgang

    1996-05-01

    We have begun a project to implement an Electronic (Filmless) Radiology Practice (ERP) at Mayo Clinic Jacksonville. This project is integrated with the implementation of a project (Automated Clinical Practice--ACP) to eliminate circulation and archival of the current paper Medical Record. The ERP will result in elimination of screen/film radiography and the transmittal of film throughout the institution by the end of 1996. In conjunction with the ACP, paper and film will not circulate within the clinic by the end of this year.

  13. Phase I Trial of Intratumoral Administration of NIS Expressing Strain of Measles Virus in Unresectable or Recurrent Malignant Peripheral Nerve Sheath Tumor

    DTIC Science & Technology

    2016-10-01

    Release; Distribution Unlimited 13. SUPPLEMENTARY NOTES 14. ABSTRACT Study approved by Mayo IRB on April 18 , 2016, and by USAMRMC/ORP/HRPO on May 6...MV-NIS, Oncolytic Virus, Measles Virus 16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF ABSTRACT 18 . NUMBER OF PPAGES 19a. NAME OF...1. Received Mayo IRB approval on 04/ 18 /2016 2. The US Army Medical Research and Materiel Command (USAMRMC), Office of Research Protections (ORP

  14. The Strategic Imperative for the Use of Social Media in Health Care.

    PubMed

    Kotsenas, Amy L; Arce, Makala; Aase, Lee; Timimi, Farris K; Young, Colleen; Wald, John T

    2018-01-01

    Although health care lags behind many other industries in adopting social media as part of a business strategy, the Mayo Clinic recognized the importance of these applications more than a decade ago. In addition to typical media relations and marketing tactics, the Mayo Clinic has successfully used social media as part of an overall program to support the strategic imperatives of the institution. Copyright © 2017 American College of Radiology. Published by Elsevier Inc. All rights reserved.

  15. Fully automatic time-window selection using machine learning for global adjoint tomography

    NASA Astrophysics Data System (ADS)

    Chen, Y.; Hill, J.; Lei, W.; Lefebvre, M. P.; Bozdag, E.; Komatitsch, D.; Tromp, J.

    2017-12-01

    Selecting time windows from seismograms such that the synthetic measurements (from simulations) and measured observations are sufficiently close is indispensable in a global adjoint tomography framework. The increasing amount of seismic data collected everyday around the world demands "intelligent" algorithms for seismic window selection. While the traditional FLEXWIN algorithm can be "automatic" to some extent, it still requires both human input and human knowledge or experience, and thus is not deemed to be fully automatic. The goal of intelligent window selection is to automatically select windows based on a learnt engine that is built upon a huge number of existing windows generated through the adjoint tomography project. We have formulated the automatic window selection problem as a classification problem. All possible misfit calculation windows are classified as either usable or unusable. Given a large number of windows with a known selection mode (select or not select), we train a neural network to predict the selection mode of an arbitrary input window. Currently, the five features we extract from the windows are its cross-correlation value, cross-correlation time lag, amplitude ratio between observed and synthetic data, window length, and minimum STA/LTA value. More features can be included in the future. We use these features to characterize each window for training a multilayer perceptron neural network (MPNN). Training the MPNN is equivalent to solve a non-linear optimization problem. We use backward propagation to derive the gradient of the loss function with respect to the weighting matrices and bias vectors and use the mini-batch stochastic gradient method to iteratively optimize the MPNN. Numerical tests show that with a careful selection of the training data and a sufficient amount of training data, we are able to train a robust neural network that is capable of detecting the waveforms in an arbitrary earthquake data with negligible detection error compared to existing selection methods (e.g. FLEXWIN). We will introduce in detail the mathematical formulation of the window-selection-oriented MPNN and show very encouraging results when applying the new algorithm to real earthquake data.

  16. Fluid volume displacement at the oval and round windows with air and bone conduction stimulation.

    PubMed

    Stenfelt, Stefan; Hato, Naohito; Goode, Richard L

    2004-02-01

    The fluids in the cochlea are normally considered incompressible, and the fluid volume displacement of the oval window (OW) and the round window (RW) should be equal and of opposite phase. However, other channels, such as the cochlear and vestibular aqueducts, may affect the fluid flow. To test if the OW and RW fluid flows are equal and of opposite phase, the volume displacement was assessed by multiple point measurement at the windows with a laser Doppler vibrometer. This was done during air conduction (AC) stimulation in seven fresh human temporal bones, and with bone conduction (BC) stimulation in eight temporal bones and one human cadaver head. With AC stimulation, the average volume displacement of the two windows is within 3 dB, and the phase difference is close to 180 degrees for the frequency range 0.1 to 10 kHz. With BC stimulation, the average volume displacement difference between the two windows is greater: below 2 kHz, the volume displacement at the RW is 5 to 15 dB greater than at the OW and above 2 kHz more fluid is displaced at the OW. With BC stimulation, lesions at the OW caused only minor changes of the fluid flow at the RW.

  17. Switchable skin window induced by optical clearing method for dermal blood flow imaging

    NASA Astrophysics Data System (ADS)

    Wang, Jing; Shi, Rui; Zhu, Dan

    2013-06-01

    Optical imaging techniques have shown tremendous potential for assessing cutaneous microcirculation, but the imaging depth and contrast is limited by the strong scattering of skin. Current skin windows have to be fulfilled by surgical operation and suffer from some side effects. In this study, a switchable skin window was developed by topical application of an optical clearing agent (OCA) and saline on rat skin in vivo. The validity of the skin window was evaluated by the laser speckle contrast imaging technique, and the safety of OCA to the body was tested through histologic examinations. The results indicated that administration of OCA or saline on rat skin in vivo can open or close the window of skin repeatedly for three days. With the repair effect of hyaluronic acid and Vaseline, it is able to repeatedly visualize the dermal blood vessels and flow distribution. Long-term observation shows that there is no abnormal reflection in micro-structure, body weight, organ coefficients, histopathologic lesions, or toxic reactions compared with a control group. This switchable window will provide an effective tool not only for cutaneous microcirculation with laser speckle contrast imaging, but also for diagnosis and treatment of peripheral vascular diseases, including tumor research with various optical imaging techniques.

  18. Fluid volume displacement at the oval and round windows with air and bone conduction stimulation

    NASA Astrophysics Data System (ADS)

    Stenfelt, Stefan; Hato, Naohito; Goode, Richard L.

    2004-02-01

    The fluids in the cochlea are normally considered incompressible, and the fluid volume displacement of the oval window (OW) and the round window (RW) should be equal and of opposite phase. However, other channels, such as the cochlear and vestibular aqueducts, may affect the fluid flow. To test if the OW and RW fluid flows are equal and of opposite phase, the volume displacement was assessed by multiple point measurement at the windows with a laser Doppler vibrometer. This was done during air conduction (AC) stimulation in seven fresh human temporal bones, and with bone conduction (BC) stimulation in eight temporal bones and one human cadaver head. With AC stimulation, the average volume displacement of the two windows is within 3 dB, and the phase difference is close to 180° for the frequency range 0.1 to 10 kHz. With BC stimulation, the average volume displacement difference between the two windows is greater: below 2 kHz, the volume displacement at the RW is 5 to 15 dB greater than at the OW and above 2 kHz more fluid is displaced at the OW. With BC stimulation, lesions at the OW caused only minor changes of the fluid flow at the RW.

  19. Thrombotic Microangiopathy Care Pathway: A Consensus Statement for the Mayo Clinic Complement Alternative Pathway-Thrombotic Microangiopathy (CAP-TMA) Disease-Oriented Group.

    PubMed

    Go, Ronald S; Winters, Jeffrey L; Leung, Nelson; Murray, David L; Willrich, Maria A; Abraham, Roshini S; Amer, Hatem; Hogan, William J; Marshall, Ariela L; Sethi, Sanjeev; Tran, Cheryl L; Chen, Dong; Pruthi, Rajiv K; Ashrani, Aneel A; Fervenza, Fernando C; Cramer, Carl H; Rodriguez, Vilmarie; Wolanskyj, Alexandra P; Thomé, Stephan D; Hook, C Christopher

    2016-09-01

    Thrombotic microangiopathies (TMAs) comprise a heterogeneous set of conditions linked by a common histopathologic finding of endothelial damage resulting in microvascular thromboses and potentially serious complications. The typical clinical presentation is microangiopathic hemolytic anemia accompanied by thrombocytopenia with varying degrees of organ ischemia. The differential diagnoses are generally broad, while the workup is frequently complex and can be confusing. This statement represents the joint recommendations from a multidisciplinary team of Mayo Clinic physicians specializing in the management of TMA. It comprises a series of evidence- and consensus-based clinical pathways developed to allow a uniform approach to the spectrum of care including when to suspect TMA, what differential diagnoses to consider, which diagnostic tests to order, and how to provide initial empiric therapy, as well as some guidance on subsequent management. Copyright © 2016 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc. All rights reserved.

  20. Preliminary flight trajectories for the Apollo Soyuz test project

    NASA Technical Reports Server (NTRS)

    Brooks, J. D.

    1973-01-01

    Preliminary data are documented for a typical launch window opening, a typical in-plane case, and a typical launch window closing trajectory, not necessarily in the same daily launch window, for the Apollo Soyuz test project mission. The Soyuz will be launched first and the Apollo will be launched on the first opportunity, 7 hours 21 minutes later. If the Apollo is unable to be launched on the first opportunity, four additional opportunities are available at 30 hours 56 minutes, 54 hours 31 minutes, 78 hours 05 minutes, and 101 hours 40 minutes. If the Apollo cannot be launched in this time frame, no further attempt will be made to launch and rendezvous with the first Soyuz. Soyuz will then be deorbited; however, a second Soyuz was made available for the same purposes.

  1. Dynamic subcellular imaging of cancer cell mitosis in the brain of live mice.

    PubMed

    Momiyama, Masashi; Suetsugu, Atsushi; Kimura, Hiroaki; Chishima, Takashi; Bouvet, Michael; Endo, Itaru; Hoffman, Robert M

    2013-04-01

    The ability to visualize cancer cell mitosis and apoptosis in the brain in real time would be of great utility in testing novel therapies. In order to achieve this goal, the cancer cells were labeled with green fluorescent protein (GFP) in the nucleus and red fluorescent protein (RFP) in the cytoplasm, such that mitosis and apoptosis could be clearly imaged. A craniotomy open window was made in athymic nude mice for real-time fluorescence imaging of implanted cancer cells growing in the brain. The craniotomy window was reversibly closed with a skin flap. Mitosis of the individual cancer cells were imaged dynamically in real time through the craniotomy-open window. This model can be used to evaluate brain metastasis and brain cancer at the subcellular level.

  2. Solid pulmonary nodule risk assessment and decision analysis: comparison of four prediction models in 285 cases.

    PubMed

    Perandini, Simone; Soardi, Gian Alberto; Motton, Massimiliano; Rossi, Arianna; Signorini, Manuel; Montemezzi, Stefania

    2016-09-01

    The aim of this study was to compare classification results from four major risk prediction models in a wide population of incidentally detected solitary pulmonary nodules (SPNs) which were selected to crossmatch inclusion criteria for the selected models. A total of 285 solitary pulmonary nodules with a definitive diagnosis were evaluated by means of four major risk assessment models developed from non-screening populations, namely the Mayo, Gurney, PKUPH and BIMC models. Accuracy was evaluated by receiver operating characteristic (ROC) area under the curve (AUC) analysis. Each model's fitness to provide reliable help in decision analysis was primarily assessed by adopting a surgical threshold of 65 % and an observation threshold of 5 % as suggested by ACCP guidelines. ROC AUC values, false positives, false negatives and indeterminate nodules were respectively 0.775, 3, 8, 227 (Mayo); 0.794, 41, 6, 125 (Gurney); 0.889, 42, 0, 144 (PKUPH); 0.898, 16, 0, 118 (BIMC). Resultant data suggests that the BIMC model may be of greater help than Mayo, Gurney and PKUPH models in preoperative SPN characterization when using ACCP risk thresholds because of overall better accuracy and smaller numbers of indeterminate nodules and false positive results. • The BIMC and PKUPH models offer better characterization than older prediction models • Both the PKUPH and BIMC models completely avoided false negative results • The Mayo model suffers from a large number of indeterminate results.

  3. Delusional infestation is typically comorbid with other psychiatric diagnoses: review of 54 patients receiving psychiatric evaluation at Mayo Clinic.

    PubMed

    Hylwa, Sara A; Foster, Ashley A; Bury, Jessica E; Davis, Mark D P; Pittelkow, Mark R; Bostwick, J Michael

    2012-01-01

    Delusional infestation, which encompasses both delusions of parasitosis and delusions of infestation with inanimate objects (sometimes called Morgellons disease), has been said to represent a distinct and encapsulated delusion, that is, a stand-alone diagnosis. Anecdotally, we have observed that patients with delusional infestation often have one or more psychiatric comorbid conditions and that delusional infestation should not be regarded as a stand-alone diagnosis. The purpose of this study was to identify whether patients with delusional infestation have psychiatric comorbid conditions. We therefore identified patients who had been formally evaluated in the Department of Psychiatry during their visit to Mayo Clinic. We retrospectively searched for and reviewed the cases of all patients with delusional infestation seen from 2001 through 2007 at Mayo Clinic, Rochester, Minnesota, and who underwent psychiatric evaluation. The diagnoses resulting from psychiatric evaluation were analyzed. During the 7-year study period, 109 patients seen for delusional infestation at Mayo Clinic were referred to the Department of Psychiatry, 54 (50%) of whom actually followed through with psychiatric consultation. Of these 54 patients, 40 (74%) received additional active psychiatric diagnoses; 14 patients (26%) had delusional infestation alone. Abnormal personality traits were rarely documented. Most patients with delusional infestation have multiple coexisting or underlying psychiatric disorders. Therefore, evaluation by a psychiatrist, when possible, is advised for all patients with delusional infestation. Copyright © 2012 The Academy of Psychosomatic Medicine. Published by Elsevier Inc. All rights reserved.

  4. Assessing the inter-observer variability of Computer-Aided Nodule Assessment and Risk Yield (CANARY) to characterize lung adenocarcinomas.

    PubMed

    Nakajima, Erica C; Frankland, Michael P; Johnson, Tucker F; Antic, Sanja L; Chen, Heidi; Chen, Sheau-Chiann; Karwoski, Ronald A; Walker, Ronald; Landman, Bennett A; Clay, Ryan D; Bartholmai, Brian J; Rajagopalan, Srinivasan; Peikert, Tobias; Massion, Pierre P; Maldonado, Fabien

    2018-01-01

    Lung adenocarcinoma (ADC), the most common lung cancer type, is recognized increasingly as a disease spectrum. To guide individualized patient care, a non-invasive means of distinguishing indolent from aggressive ADC subtypes is needed urgently. Computer-Aided Nodule Assessment and Risk Yield (CANARY) is a novel computed tomography (CT) tool that characterizes early ADCs by detecting nine distinct CT voxel classes, representing a spectrum of lepidic to invasive growth, within an ADC. CANARY characterization has been shown to correlate with ADC histology and patient outcomes. This study evaluated the inter-observer variability of CANARY analysis. Three novice observers segmented and analyzed independently 95 biopsy-confirmed lung ADCs from Vanderbilt University Medical Center/Nashville Veterans Administration Tennessee Valley Healthcare system (VUMC/TVHS) and the Mayo Clinic (Mayo). Inter-observer variability was measured using intra-class correlation coefficient (ICC). The average ICC for all CANARY classes was 0.828 (95% CI 0.76, 0.895) for the VUMC/TVHS cohort, and 0.852 (95% CI 0.804, 0.901) for the Mayo cohort. The most invasive voxel classes had the highest ICC values. To determine whether nodule size influenced inter-observer variability, an additional cohort of 49 sub-centimeter nodules from Mayo were also segmented by three observers, with similar ICC results. Our study demonstrates that CANARY ADC classification between novice CANARY users has an acceptably low degree of variability, and supports the further development of CANARY for clinical application.

  5. Quality improvement education incorporated as an integral part of critical care fellows training at the Mayo Clinic.

    PubMed

    Kashani, Kianoush B; Ramar, Kannan; Farmer, J Christopher; Lim, Kaiser G; Moreno-Franco, Pablo; Morgenthaler, Timothy I; Dankbar, Gene C; Hale, Curt W

    2014-10-01

    The Accreditation Council for Graduate Medical Education emphasizes quality improvement (QI) education in residency/fellowship training programs. The Mayo Clinic Combined Critical Care Fellowship (CCF) program conducted a pilot QI education program to incorporate QI training as a required curriculum for the 2010-2011 academic year. CCF collaborated with the Mayo Quality Academy to customize and teach the existing Mayo Quality Fellows curriculum to the CCF fellows with the help of two quality coaches over five months starting July 2010. All fellows were to achieve Bronze and Silver certification prior to graduation. Silver required passing four written exams and submitting a health care QI project. Five projects were selected on the basis of the Impact-Effort Prioritization matrix, and DMAIC (Define, Measure, Analyze, Improve, and Control) methodology was used to complete the projects. The primary outcome was to assess learners' satisfaction, knowledge, and skill transfer. All 20 fellows were Bronze certified, and 14 (70%) were Silver certified by the time of graduation. All five QI projects were completed and showed positive impacts on patient safety and care. Surveys showed improved learner satisfaction. Graduates felt the QI training improved their QI skills and employment and career advancement. The QI curriculum had appropriate content and teaching pace and did not significantly displace other important clinical core curriculum topics. The pilot was successfully implemented in the CCF program and now is in the fourth academic year as an established and integral part of the fellowship core curriculum.

  6. Practical method and device for enhancing pulse contrast ratio for lasers and electron accelerators

    DOEpatents

    Zhang, Shukui; Wilson, Guy

    2014-09-23

    An apparatus and method for enhancing pulse contrast ratios for drive lasers and electron accelerators. The invention comprises a mechanical dual-shutter system wherein the shutters are placed sequentially in series in a laser beam path. Each shutter of the dual shutter system has an individually operated trigger for opening and closing the shutter. As the triggers are operated individually, the delay between opening and closing first shutter and opening and closing the second shutter is variable providing for variable differential time windows and enhancement of pulse contrast ratio.

  7. Pediatric falls from windows and balconies: incidents and risk factors as reported by newspapers in the United Arab Emirates.

    PubMed

    Grivna, Michal; Al-Marzouqi, Hanan M; Al-Ali, Maryam R; Al-Saadi, Nada N; Abu-Zidan, Fikri M

    2017-01-01

    Falls of children from heights (balconies and windows) usually result in severe injuries and death. Details on child falls from heights in the United Arab Emirates (UAE) are not easily accessible. Our aim was to assess the incidents, personal, and environmental risk factors for pediatric falls from windows/balconies using newspaper clippings. We used a retrospective study design to electronically assess all major UAE national Arabic and English newspapers for reports of unintentional child falls from windows and balconies during 2005-2016. A structured data collection form was developed to collect information. Data were entered into an Excel sheet and descriptive analysis was performed. Newspaper clippings documented 96 fall incidents. After cleaning the data and excluding duplicate cases and intentional injuries, 81 cases were included into the final analysis. Fifty-three percent ( n  = 42) were boys. The mean (range) age was 4.9 years (1-15). Thirty-eight (47%) children fell from windows and 36 (44%) from balconies. Twenty-two (27%) children climbed on the furniture placed on a balcony or close to a window. Twenty-five (31%) children were not alone in the apartment when they fell. Twenty-nine children fell from less than 5 floors (37%), 33 from 5 to 10 floors (42%) and 16 from more than 10 floors (21%) . Fifteen children (19%) were hospitalized and survived the fall incident, while 66 died (81%). Newspapers proved to be useful to study pediatric falls from heights. It is necessary to improve window safety by installing window guards and raising awareness.

  8. Trauma and Contemporary Forms of Subjectivity: Contributions of Argentine Psychoanalysis.

    PubMed

    Volnovich, Juan Carlos

    2017-04-01

    This paper offers arguments to justify the relevance of psychoanalysis-psychoanalyses-in present-day Argentina and reflects on the stance taken by psychoanalysts with different theoretical perspectives in the face of the havoc wreaked by state terror (1976-1983). To this end, the author focuses on the pioneers' traits, the significance of the Argentine Psychoanalytic Association in the 1950s and 1960s, and the impact of the departure of the Plataforma Group in 1971. The establishment of the latter opened the way for the development of a psychoanalysis tied to popular movements, sensitive to social conflict, and close to human rights organizations. The author explores both on psychoanalysts' intervention to address the social trauma resulting from the theft of babies during the dictatorship, and on their relationship with Grandmothers of Plaza de Mayo.

  9. Wind-driven roof turbines: a novel way to improve ventilation for TB infection control in health facilities.

    PubMed

    Cox, Helen; Escombe, Rod; McDermid, Cheryl; Mtshemla, Yolanda; Spelman, Tim; Azevedo, Virginia; London, Leslie

    2012-01-01

    Tuberculosis transmission in healthcare facilities contributes significantly to the TB epidemic, particularly in high HIV settings. Although improving ventilation may reduce transmission, there is a lack of evidence to support low-cost practical interventions. We assessed the efficacy of wind-driven roof turbines to achieve recommended ventilation rates, compared to current recommended practices for natural ventilation (opening windows), in primary care clinic rooms in Khayelitsha, South Africa. Room ventilation was assessed (CO₂ gas tracer technique) in 4 rooms where roof turbines and air-intake grates were installed, across three scenarios: turbine, grate and window closed, only window open, and only turbine and grate open, with concurrent wind speed measurement. 332 measurements were conducted over 24 months. For all 4 rooms combined, median air changes per hour (ACH) increased with wind speed quartiles across all scenarios. Higher median ACH were recorded with open roof turbines and grates, compared to open windows across all wind speed quartiles. Ventilation with open turbine and grate exceeded WHO-recommended levels (60 Litres/second/patient) for 95% or more of measurements in 3 of the 4 rooms; 47% in the remaining room, where wind speeds were lower and a smaller diameter turbine was installed. High room ventilation rates, meeting recommended thresholds, may be achieved using wind-driven roof turbines and grates, even at low wind speeds. Roof turbines and air-intake grates are not easily closed by staff, allowing continued ventilation through colder periods. This simple, low-cost technology represents an important addition to our tools for TB infection control.

  10. Wind-Driven Roof Turbines: A Novel Way to Improve Ventilation for TB Infection Control in Health Facilities

    PubMed Central

    Cox, Helen; Escombe, Rod; McDermid, Cheryl; Mtshemla, Yolanda; Spelman, Tim; Azevedo, Virginia; London, Leslie

    2012-01-01

    Objective Tuberculosis transmission in healthcare facilities contributes significantly to the TB epidemic, particularly in high HIV settings. Although improving ventilation may reduce transmission, there is a lack of evidence to support low-cost practical interventions. We assessed the efficacy of wind-driven roof turbines to achieve recommended ventilation rates, compared to current recommended practices for natural ventilation (opening windows), in primary care clinic rooms in Khayelitsha, South Africa. Methods Room ventilation was assessed (CO2 gas tracer technique) in 4 rooms where roof turbines and air-intake grates were installed, across three scenarios: turbine, grate and window closed, only window open, and only turbine and grate open, with concurrent wind speed measurement. 332 measurements were conducted over 24 months. Findings For all 4 rooms combined, median air changes per hour (ACH) increased with wind speed quartiles across all scenarios. Higher median ACH were recorded with open roof turbines and grates, compared to open windows across all wind speed quartiles. Ventilation with open turbine and grate exceeded WHO-recommended levels (60 Litres/second/patient) for 95% or more of measurements in 3 of the 4 rooms; 47% in the remaining room, where wind speeds were lower and a smaller diameter turbine was installed. Conclusion High room ventilation rates, meeting recommended thresholds, may be achieved using wind-driven roof turbines and grates, even at low wind speeds. Roof turbines and air-intake grates are not easily closed by staff, allowing continued ventilation through colder periods. This simple, low-cost technology represents an important addition to our tools for TB infection control. PMID:22253742

  11. Optimizing the patient transport function at Mayo Clinic.

    PubMed

    Kuchera, Dustin; Rohleder, Thomas R

    2011-01-01

    In this article, we report on the implementation of a computerized scheduling tool to optimize staffing for patient transport at the Mayo Clinic. The tool was developed and implemented in Microsoft Excel and Visual Basic for Applications and includes an easy-to-use interface. The tool allows transport management to consider the trade-offs between patient waiting time and staffing levels. While improved staffing efficiency was a desire of the project, it was important that patient service quality was also maintained. The results show that staffing could be reduced while maintaining historical patient service levels.

  12. Securing Tyrants or Fostering Reform? U.S. Internal Security Assistance to Repressive and Transitioning Regimes

    DTIC Science & Technology

    2006-01-01

    los Derechos Humanos , “Informe de Labores, Junio 1997–Mayo 1998,” San Salvador, 1998, pp. 230–238. Also see Call, “Democratisation, War and State...countries in the region: Costa Rica, Guatemala, Haiti, Mexico, and Panama. Based on 57 Procuraduría para la Defensa de los Derechos Humanos , pp. 230–238...www.state.gov/p/sa/rls/rm/26277.htm. Procuraduría para la Defensa de los Derechos Humanos , “Informe de Labores, Junio 1997–Mayo 1998,” San Salvador, 1998

  13. Phase I Trial of Intratumoral Administration of NIS-Expressing Strain of Measles Virus in Unresectable or Recurrent Malignant Peripheral Nerve Sheath Tumor

    DTIC Science & Technology

    2017-10-01

    Distribution Unlimited 13. SUPPLEMENTARY NOTES 14. ABSTRACT Study approved by Mayo IRB on April 18 , 2016, and by USAMRMC/ORP/HRPO on May 6, 2016. All...Sheath Tumor(MPNST), MV-NIS, Oncolytic Virus, Measles Virus 16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF ABSTRACT 18 . NUMBER OF PPAGES 19a. NAME...virus incorporation and persistence in MPNST after injection Subtask 2: Assess viremia and viral shedding 1. Received Mayo IRB approval on 04/ 18 /2016

  14. Antimycobacterial activity of medicinal plants used by the Mayo people of Sonora, Mexico.

    PubMed

    Coronado-Aceves, Enrique Wenceslao; Sánchez-Escalante, José Jesús; López-Cervantes, Jaime; Robles-Zepeda, Ramón Enrique; Velázquez, Carlos; Sánchez-Machado, Dalia Isabel; Garibay-Escobar, Adriana

    2016-08-22

    Tuberculosis (TB) is an infectious disease mainly caused by Mycobacterium tuberculosis (Mtb), which generates 9 million new cases worldwide each year. The Mayo ethnicity of southern Sonora, Mexico is more than 2000 years old, and the Mayos possess extensive knowledge of traditional medicine. To evaluate the antimycobacterial activity levels of extracts of medicinal plants used by the Mayos against Mtb and Mycobacterium smegmatis (Msm) in the treatment of TB, respiratory diseases and related symptoms. A total of 34 plant species were collected, and 191 extracts were created with n-hexane, dichloromethane, ethyl acetate (EtOAc), methanol and water. Their minimum inhibitory concentrations (MICs) and minimum bactericidal concentrations (MBCs) were determined against Mtb H37Rv using the microplate alamar blue assay (MABA) and against Msm using the resazurin microplate assay (REMA) at 6 and 2 days of exposure, respectively, and at concentrations of 250-1.9µg/mL (n-hexane extracts) and 1000-7.81µg/mL (extracts obtained with dichloromethane, EtOAc, methanol and water). Rhynchosia precatoria (Willd.) DC. (n-hexane root extract), Euphorbia albomarginata Torr. and A. Gray. (EtOAc shoot extract) and Helianthus annuus L. (n-hexane stem extract) were the most active plants against Mtb H37Rv, with MICs of 15.6, 250, 250µg/mL and MBCs of 31.25, 250, 250µg/mL, respectively. R. precatoria (root) was the only active plant against Msm, with MIC and MBC values of ≥250µg/mL. None of the aqueous extracts were active. This study validates the medicinal use of certain plants used by the Mayo people in the treatment of TB and related symptoms. R. precatoria, E. albomarginata and H. annuus are promising plant sources of active compounds that act against Mtb H37Rv. To our knowledge, this is the first time that their antimycobacterial activity has been reported. Crude extracts obtained with n-hexane, EtOAc and dichloromethane were the most active against Mtb H37Rv. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  15. Comparison of two extracorporeal shock wave therapy techniques for the treatment of painful subcalcaneal spur. A randomized controlled study.

    PubMed

    Tornese, Davide; Mattei, Enrico; Lucchesi, Giampaolo; Bandi, Marco; Ricci, Gabriele; Melegati, Gianluca

    2008-09-01

    To describe and compare two extracorporeal shock wave therapy techniques for the treatment of painful subcalcaneal spur. Random assignment to two groups of treatment with two and eight months follow-up. The data were collected in outpatients. Forty-five subjects with a history of at least six months of heel pain were studied. Each subject received a three-session ultrasound-guided extracorporeal shock wave therapy (performed weekly). Perpendicular technique was used in group A (n=22, mean age 59.3 +/- 12 years) and tangential technique was used in group B (n= 23, mean age 58.8 +/- 12.3 years). Mayo Clinical Scoring System was used to evaluate each subject before the treatment and at two and eight months follow-up. Mayo Clinical Scoring System pretreatment scores were homogeneous between the groups (group A 55.2 +/-18.7; group B 53.5 +/- 20; P>0.05). In both groups there was a significant (P<0.05) increase in the Mayo Clinical Scoring System score at two months (group A 83.9 +/- 13.7; group B 80 +/- 15,8) and eight months (group A 90 +/- 10.5; group B 90.2 +/-8.7) follow-up. No significant differences were obtained comparing the Mayo Clinical Scoring System scores of the two groups at two and eight months follow-up. There was no difference between the two techniques of using extracorporeal shock wave therapy. The tangential technique was found to be better tolerated as regards treatment-induced pain, allowing higher energy dosages to be used.

  16. Success of a Faculty Development Program for Teachers at the Mayo Clinic

    PubMed Central

    Lee, Staci M.; Lee, Mark C.; Reed, Darcy A.; Halvorsen, Andrew J.; Berbari, Elie F.; McDonald, Furman S.; Beckman, Thomas J.

    2014-01-01

    Background There has been limited research on the improvement of underperforming clinical teachers. Objective To determine whether a faculty development program could improve the evaluations of clinical teachers in an internal medicine residency program. Methods A total of 123 teachers completed faculty development at the Mayo Clinic from 2009 to 2012. The faculty enhancement and education development program (FEED) consists of 6 interactive, small group, 2-hour sessions taught by experienced Mayo Clinic faculty over 1 year. These sessions address the following competencies: asking questions, diagnosing learners, giving feedback, using teaching frameworks, recognizing learning styles, and providing clinical supervision. Resident-of-faculty Mayo teaching effectiveness (MTE) scores have previously demonstrated content, internal structure, and criterion validity. Teachers were grouped into the top 80% or the bottom 20%, according to baseline MTE scores. Mixed linear models were used to compare these groups regarding changes in MTE scores after completion of FEED. Results were adjusted for teacher age, sex, medical specialty, academic rank, and teaching awards. Results For all participants combined, the adjusted MTE scores (mean; standard error) improved from baseline (3.80; 0.04) to completion of FEED (3.93; 0.04; P < .001). However, the bottom 20% had a significantly greater improvement in scores than the top 80% (score-change difference  =  0.166, P < .001). Conclusions We describe a low-intensity faculty development intervention that benefited all clinical teachers, but was particularly effective for underperforming teachers in internal medicine. The approach may be suitable for adoption or adaptation in other graduate medical education programs. PMID:26140122

  17. Design and validity of a clinic-based case-control study on the molecular epidemiology of lymphoma

    PubMed Central

    Cerhan, James R; Fredericksen, Zachary S; Wang, Alice H; Habermann, Thomas M; Kay, Neil E; Macon, William R; Cunningham, Julie M; Shanafelt, Tait D; Ansell, Stephen M; Call, Timothy G; Witzig, Thomas E; Slager, Susan L; Liebow, Mark

    2011-01-01

    We present the design features and implementation of a clinic-based case-control study on the molecular epidemiology of lymphoma conducted at the Mayo Clinic (Rochester, Minnesota, USA), and then assess the internal and external validity of the study. Cases were newly diagnosed lymphoma patients from Minnesota, Iowa and Wisconsin seen at Mayo and controls were patients from the same region without lymphoma who had a pre-scheduled general medical examination, frequency matched on age, sex and residence. Overall response rates were 67% for cases and 70% for controls; response rates were lower for cases and controls over age 70 years, cases with more aggressive disease, and controls from the local area, although absolute differences were modest. Cases and controls were well-balanced on age, sex, and residence characteristics. Demographic and disease characteristics of NHL cases were similar to population-based cancer registry data. Control distributions were similar to population-based data on lifestyle factors and minor allele frequencies of over 500 SNPs, although smoking rates were slightly lower. Associations with NHL in the Mayo study for smoking, alcohol use, family history of lymphoma, autoimmune disease, asthma, eczema, body mass index, and single nucleotide polymorphisms in TNF (rs1800629), LTA (rs909253), and IL10 (rs1800896) were at a magnitude consistent with estimates from pooled studies in InterLymph, with history of any allergy the only directly discordant result in the Mayo study. These data suggest that this study should have strong internal and external validity. This framework may be useful to others who are designing a similar study. PMID:21686124

  18. Clinical documentation variations and NLP system portability: a case study in asthma birth cohorts across institutions.

    PubMed

    Sohn, Sunghwan; Wang, Yanshan; Wi, Chung-Il; Krusemark, Elizabeth A; Ryu, Euijung; Ali, Mir H; Juhn, Young J; Liu, Hongfang

    2017-11-30

    To assess clinical documentation variations across health care institutions using different electronic medical record systems and investigate how they affect natural language processing (NLP) system portability. Birth cohorts from Mayo Clinic and Sanford Children's Hospital (SCH) were used in this study (n = 298 for each). Documentation variations regarding asthma between the 2 cohorts were examined in various aspects: (1) overall corpus at the word level (ie, lexical variation), (2) topics and asthma-related concepts (ie, semantic variation), and (3) clinical note types (ie, process variation). We compared those statistics and explored NLP system portability for asthma ascertainment in 2 stages: prototype and refinement. There exist notable lexical variations (word-level similarity = 0.669) and process variations (differences in major note types containing asthma-related concepts). However, semantic-level corpora were relatively homogeneous (topic similarity = 0.944, asthma-related concept similarity = 0.971). The NLP system for asthma ascertainment had an F-score of 0.937 at Mayo, and produced 0.813 (prototype) and 0.908 (refinement) when applied at SCH. The criteria for asthma ascertainment are largely dependent on asthma-related concepts. Therefore, we believe that semantic similarity is important to estimate NLP system portability. As the Mayo Clinic and SCH corpora were relatively homogeneous at a semantic level, the NLP system, developed at Mayo Clinic, was imported to SCH successfully with proper adjustments to deal with the intrinsic corpus heterogeneity. © The Author 2017. Published by Oxford University Press on behalf of the American Medical Informatics Association. All rights reserved. For Permissions, please email: journals.permissions@oup.com

  19. Extender for securing a closure

    DOEpatents

    Thomas, II, Patrick A.

    2012-10-02

    An apparatus for securing a closure such as door or a window that opens and closes by movement relative to a fixed structure such as a wall or a floor. Many embodiments provide a device for relocating a padlock from its normal location where it secures a fastener (such as a hasp) to a location for the padlock that is more accessible for locking and unlocking the padlock. Typically an extender is provided, where the extender has a hook at a first end that is disposed through the eye of the staple of the hasp, and at an opposing second end the extender has an annulus, such as a hole in the extender or a loop or ring affixed to the extender. The shackle of the padlock may be disposed through the annulus and may be disposed through the eye of a second staple to secure the door or window in a closed or open position. Some embodiments employ a rigid sheath to enclose at least a portion of the extender. Typically the rigid sheath has an open state where the hook is exposed outside the sheath and a closed state where the hook is disposed within the sheath.

  20. The Impact of Myriad and Mayo: Will Advancements in the Biological Sciences Be Spurred or Disincentivized? (Or Was Biotech Patenting Not Complicated Enough?)

    PubMed Central

    Gordon, Jennifer

    2015-01-01

    For years, purified and isolated naturally occurring biological substances of great medical importance—including genes—have been the subject of U.S. patents. Similarly, methods in which the detection of a biological substance (e.g., in a blood sample) dictates subsequent actions, as in disease diagnostics and treatment, have long enjoyed patent protection. However, two recent Supreme Court cases, Association for Molecular Pathology v. Myriad Genetics, Inc. (133 S. Ct. 2107) (2013) and Mayo Collaborative Services v. Prometheus Laboratories, Inc. (132 S. Ct. 1289) (2012), have shaken up the status quo of biotech patenting. The highest court in our land unanimously agreed with patent challengers that much of what we took for granted as patentable subject matter is not, as a matter of law, eligible for patenting after all. This review discusses the Myriad and Mayo cases, their impact on which biology-based innovations we may or may not continue to patent, and whether the altered status quo is benignly corrective or gravely disruptive. Is what happened here a good thing or not? PMID:25502748

  1. Origin and history of chondrite regolith, fragmental and impact-melt breccias from Spain

    NASA Technical Reports Server (NTRS)

    Casanova, I.; Keil, K.; Wieler, R.; San Miguel, A.; King, E. A.

    1990-01-01

    Six ordinary chondrite breccias from the Museo Nacional de Ciencias Naturales, Madrid (Spain), are described and classified as follows: the solar gas-rich regolith breccia Oviedo (H5); the premetamorphic fragmental breccias Cabezo de Mayo (type 6, L-LL), and Sevilla (LL4); the fragmental breccias Canellas (H4) and Gerona (H5); and the impact melt breccia, Madrid (L6). It is confirmed that chondrites with typical light-dark structures and petrographic properties typical of regolith breccias may (Oviedo) or may not (Canellas) be solar gas-rich. Cabezo de Mayo and Sevilla show convincing evidence that they were assembled prior to peak metamorphism and were equilibrated during subsequent reheating. Compositions of olivine and low-Ca pyroxene in host chondrite and breccia clasts in Cabezo de Mayo are transitional between groups L and LL. It is suggested, based on mineralogic and oxygen isotopic compositions of host and clasts, that the rock formed on the L parent body by mixing, prior to peak metamorphism. This was followed by partial equilibrium of two different materials: the indigenous L chondrite host and exotic LL melt rock clasts.

  2. Origin and history of chondrite regolith, fragmental and impact-melt breccias from Spain

    NASA Astrophysics Data System (ADS)

    Casanova, I.; Keil, K.; Wieler, R.; San Miguel, A.; King, E. A.

    1990-06-01

    Six ordinary chondrite breccias from the Museo Nacional de Ciencias Naturales, Madrid (Spain), are described and classified as follows: the solar gas-rich regolith breccia Oviedo (H5); the premetamorphic fragmental breccias Cabezo de Mayo (type 6, L-LL), and Sevilla (LL4); the fragmental breccias Canellas (H4) and Gerona (H5); and the impact melt breccia, Madrid (L6). It is confirmed that chondrites with typical light-dark structures and petrographic properties typical of regolith breccias may (Oviedo) or may not (Canellas) be solar gas-rich. Cabezo de Mayo and Sevilla show convincing evidence that they were assembled prior to peak metamorphism and were equilibrated during subsequent reheating. Compositions of olivine and low-Ca pyroxene in host chondrite and breccia clasts in Cabezo de Mayo are transitional between groups L and LL. It is suggested, based on mineralogic and oxygen isotopic compositions of host and clasts, that the rock formed on the L parent body by mixing, prior to peak metamorphism. This was followed by partial equilibrium of two different materials: the indigenous L chondrite host and exotic LL melt rock clasts.

  3. Clinical care management and workflow by episodes.

    PubMed Central

    Claus, P. L.; Carpenter, P. C.; Chute, C. G.; Mohr, D. N.; Gibbons, P. S.

    1997-01-01

    This paper describes the implementation of clinically defined episodes of care and the introduction of an episode-based summary list of patient problems across Mayo Clinic Rochester in 1996 and 1997. Although Mayo's traditional paper-based system has always relied on a type of 'episode of care' (called the "registration") for patient and history management, a new, more clinically relevant definition of episode of care was put into practice in November 1996. This was done to improve care management and operational processes and to provide a basic construct for the electronic medical record. Also since November 1996, a computer-generated summary list of patient problems, the "Master Sheet Summary Report," organized by episode, has been placed in all patient histories. In the third quarter of 1997, the ability to view the episode-based problem summary online was made available to the 3000+ EMR-capable workstations deployed across the Mayo Rochester campus. In addition, the clinically oriented problem summarization process produces an improved basic "package" of clinical information expected to lead to improved analytic decision support, outcomes analysis and epidemiological research. PMID:9357595

  4. Strategic performance management: development of a performance measurement system at the Mayo Clinic.

    PubMed

    Curtright, J W; Stolp-Smith, S C; Edell, E S

    2000-01-01

    Managing and measuring performance become exceedingly complex as healthcare institutions evolve into integrated health systems comprised of hospitals, outpatient clinics and surgery centers, nursing homes, and home health services. Leaders of integrated health systems need to develop a methodology and system that align organizational strategies with performance measurement and management. To meet this end, multiple healthcare organizations embrace the performance-indicators reporting system known as a "balanced scorecard" or a "dashboard report." This discrete set of macrolevel indicators gives senior management a fast but comprehensive glimpse of the organization's performance in meeting its quality, operational, and financial goals. The leadership of outpatient operations for Mayo Clinic in Rochester, Minnesota built on this concept by creating a performance management and measurement system that monitors and reports how well the organization achieves its performance goals. Internal stakeholders identified metrics to measure performance in each key category. Through these metrics, the organization links Mayo Clinic's vision, primary value, core principles, and day-to-day operations by monitoring key performance indicators on a weekly, monthly, or quarterly basis.

  5. Digital dissection system for medical school anatomy training

    NASA Astrophysics Data System (ADS)

    Augustine, Kurt E.; Pawlina, Wojciech; Carmichael, Stephen W.; Korinek, Mark J.; Schroeder, Kathryn K.; Segovis, Colin M.; Robb, Richard A.

    2003-05-01

    As technology advances, new and innovative ways of viewing and visualizing the human body are developed. Medicine has benefited greatly from imaging modalities that provide ways for us to visualize anatomy that cannot be seen without invasive procedures. As long as medical procedures include invasive operations, students of anatomy will benefit from the cadaveric dissection experience. Teaching proper technique for dissection of human cadavers is a challenging task for anatomy educators. Traditional methods, which have not changed significantly for centuries, include the use of textbooks and pictures to show students what a particular dissection specimen should look like. The ability to properly carry out such highly visual and interactive procedures is significantly constrained by these methods. The student receives a single view and has no idea how the procedure was carried out. The Department of Anatomy at Mayo Medical School recently built a new, state-of-the-art teaching laboratory, including data ports and power sources above each dissection table. This feature allows students to access the Mayo intranet from a computer mounted on each table. The vision of the Department of Anatomy is to replace all paper-based resources in the laboratory (dissection manuals, anatomic atlases, etc.) with a more dynamic medium that will direct students in dissection and in learning human anatomy. Part of that vision includes the use of interactive 3-D visualization technology. The Biomedical Imaging Resource (BIR) at Mayo Clinic has developed, in collaboration with the Department of Anatomy, a system for the control and capture of high resolution digital photographic sequences which can be used to create 3-D interactive visualizations of specimen dissections. The primary components of the system include a Kodak DC290 digital camera, a motorized controller rig from Kaidan, a PC, and custom software to synchronize and control the components. For each dissection procedure, the images are captured automatically, and then processed to generate a Quicktime VR sequence, which permits users to view an object from multiple angles by rotating it on the screen. This provides 3-D visualizations of anatomy for students without the need for special '3-D glasses' that would be impractical to use in a laboratory setting. In addition, a digital video camera may be mounted on the rig for capturing video recordings of selected dissection procedures being carried out by expert anatomists for playback by the students. Anatomists from the Department of Anatomy at Mayo have captured several sets of dissection sequences and processed them into Quicktime VR sequences. The students are able to look at these specimens from multiple angles using this VR technology. In addition, the student may zoom in to obtain high-resolution close-up views of the specimen. They may interactively view the specimen at varying stages of dissection, providing a way to quickly and intuitively navigate through the layers of tissue. Electronic media has begun to impact all areas of education, but a 3-D interactive visualization of specimen dissections in the laboratory environment is a unique and powerful means of teaching anatomy. When fully implemented, anatomy education will be enhanced significantly by comparison to traditional methods.

  6. Carbon Nanofiber Nanoelectrodes for Biosensing Applications

    NASA Technical Reports Server (NTRS)

    Koehne, Jessica Erin

    2014-01-01

    A sensor platform based on vertically aligned carbon nanofibers (CNFs) has been developed. Their inherent nanometer scale, high conductivity, wide potential window, good biocompatibility and well-defined surface chemistry make them ideal candidates as biosensor electrodes. Here, we report two studies using vertically aligned CNF nanoelectrodes for biomedical applications. CNF arrays are investigated as neural stimulation and neurotransmitter recording electrodes for application in deep brain stimulation (DBS). Polypyrrole coated CNF nanoelectrodes have shown great promise as stimulating electrodes due to their large surface area, low impedance, biocompatibility and capacity for highly localized stimulation. CNFs embedded in SiO2 have been used as sensing electrodes for neurotransmitter detection. Our approach combines a multiplexed CNF electrode chip, developed at NASA Ames Research Center, with the Wireless Instantaneous Neurotransmitter Concentration Sensor (WINCS) system, developed at the Mayo Clinic. Preliminary results indicate that the CNF nanoelectrode arrays are easily integrated with WINCS for neurotransmitter detection in a multiplexed array format. In the future, combining CNF based stimulating and recording electrodes with WINCS may lay the foundation for an implantable smart therapeutic system that utilizes neurochemical feedback control while likely resulting in increased DBS application in various neuropsychiatric disorders. In total, our goal is to take advantage of the nanostructure of CNF arrays for biosensing studies requiring ultrahigh sensitivity, high-degree of miniaturization, and selective biofunctionalization.

  7. Quest for quality: department of laboratory medicine and pathology, Mayo Clinic.

    PubMed

    Arney, Kris R; Hopper, Mary H; Tran, Sheryl A; Ward, Melissa M; Hanson, Curtis A

    2004-01-01

    This article describes our journey for quality in the Department of Laboratory Medicine and Pathology (DLMP) at Mayo Clinic. It provides the background of the department and the process for the development and implementation of the quality program. In addition, a quality conference and the development of a quality school are outlined. Throughout the course of this process, valuable lessons were learned and are discussed. We are pleased with the success of the quality journey. However, we realize that the quest has just begun. We look forward to the future and the challenges that lie ahead.

  8. IBM Application System/400 as the foundation of the Mayo Clinic/IBM PACS project

    NASA Astrophysics Data System (ADS)

    Rothman, Melvyn L.; Morin, Richard L.; Persons, Kenneth R.; Gibbons, Patricia S.

    1990-08-01

    An IBM Application System/400 (AS/400) anchors the Mayo Clinic/IBM joint development PACS project. This paper highlights some of the AS/400's features and the resulting benefits which make it a strong foundation for a medical image archival and review system. Among the AS/400's key features are: 1. A high-level machine architecture 2. Object orientation 3. Relational data base and other functions integrated into the system's architecture 4. High-function interfaces to IBM Personal Computers and IBM Personal System/2s' (pS/2TM).

  9. Shielding design of the Mayo Clinic Scottsdale cyclotron vault

    NASA Astrophysics Data System (ADS)

    Riper, Kenneth A. Van; Metzger, Robert L.; Nelson, Kevin

    2017-09-01

    Mayo Clinic Scottsdale (Scottsdale, Arizona) is building a cyclotron vault containing a cyclotron with adjacent targets and a beam line leading to an external target. The targets are irradiated by high energy (15 to 16.5 MeV) protons for the production of radioisotopes. We performed Monte Carlo radiation transport simulations to calculate the radiation dose outside of the vault during irradiation of the cyclotron and external targets. We present the Monte Carlo model including the geometry, sources, and variance reduction methods. Mesh tallies surrounding the vault show the external dose rate is within acceptable limits.

  10. [Case-control study on local injection of autoallergic platelet rich plasma or whole blood for the treatment of tennis elbow].

    PubMed

    Zhao, Li-Lai; Tong, Pei-Jian; Xiao, Lu-Wei; Zhu, Qiu-Liang; Xu, Bin; Yan, Mao-Hua

    2014-11-01

    To compare therapeutic effects of local injection with autoallergic platelet rich plasma (PRP) or autoallergic whole blood (AWB) for the treatment of chronic tennis elbow. From January 2011 to January 2014, 40 patients with chronic tennis elbow were divided into 2 groups, 20 cases in each group: PRP group and AWB group. There were 20 patients in PRP group treated with local injection of autoallergic platelet rich plasma, including 5 males and 15 females, with an average age of (47.50 ± 9.86) years old; and the average course of disease was (4.67 ± 3.27) months. Among the 20 patients in AWB group treated with local injection of autoallergic whole blood, 3 patients were male and 17 patients were female, with an average age of (46.50 ± 9.96) years old;and the average course of disease was (4.53 ± 2.27) months. The elbow joint was fixed with elastic stockings after injection. All the patients were guided to do strengthening and extension exercises during the follow-up period. Visual analog scale (VAS), Mayo scores for elbow and pressure pain threshold (PPT) were used to evaluate clinical effects after injection immediately and 4,8 weeks after treatment. Results:All the patients were followed up,there were no infections and swelling occurred. The VAS, Mayo and PPT scores of patients in PRP group were improved from pre-therapy 7.22 ± 1.32, 56.71 ± 10.90 and 17.47 ± 4.62 to 2.73 ± 1.00, 91.59 ± 6.95 and 21.35 ± 4.80 respectively 8 weeks after treatment. The VAS, Mayo and PPT scores of patients in AWB group were improved from pre-therapy 7.16 ±1.27, 54.72 ± 8.36 and 17.06 ± 4.83 to 3.81 ± 1.36, 82.06 ± 7.89 and 20.12 ± 4.97 respectively 8 weeks after treatment. All the pain and functional variables including VAS, PPT, and Mayo scores were improved significantly in both groups 4 weeks after injection. On the 4th week after injection, there was no statistically significant difference in PPT between two groups; while the VAS and Mayo score of AWB group were lower than those of PRP group. On the 8th week after injection, the VAS of AWB group was higher than that of PRP group; but the Mayo and PPT scores of AWB group were lower than those of PRP group. PRP and AWB injections are both effective to treat chronic lateral epicondylitis. Compared with AWB injection, PRP injection may be more effective in releasing pain and improving function for a longer time.

  11. Particulates and noise exposure during bicycle, bus and car commuting: A study in three European cities.

    PubMed

    Okokon, Enembe O; Yli-Tuomi, Tarja; Turunen, Anu W; Taimisto, Pekka; Pennanen, Arto; Vouitsis, Ilias; Samaras, Zissis; Voogt, Marita; Keuken, Menno; Lanki, Timo

    2017-04-01

    In order to curb traffic-related air pollution and its impact on the physical environment, contemporary city commuters are encouraged to shift from private car use to active or public transport modes. However, personal exposures to particulate matter (PM), black carbon and noise during commuting may be substantial. Therefore, studies comparing exposures during recommended modes of transport versus car trips are needed. We measured personal exposure to various-sized particulates, soot, and noise during commuting by bicycle, bus and car in three European cities: Helsinki in Finland, Rotterdam in the Netherlands and Thessaloniki in Greece using portable monitoring devices. We monitored commonly travelled routes in these cities. The total number of one-way trips yielding data on any of the measured parameters were 84, 72, 94 and 69 for bicycle, bus, closed-window car and open-window car modes, respectively. The highest mean PM 2.5 (85µg/m 3 ), PM 10 (131µg/m 3 ), black carbon (10.9µg/m 3 ) and noise (75dBA) levels were recorded on the bus, bus (again), open-window car and bicycle modes, respectively, all in Thessaloniki, PM and soot concentrations were generally higher during biking and taking a bus than during a drive in a a car with closed windows. Ratios of bike:car PM 10 ranged from 1.1 in Thessaloniki to 2.6 in Helsinki, while bus:car ratios ranged from in 1.0 in Rotterdam to 5.6 in Thessaloniki. Higher noise levels were mostly recorded during bicycle rides. Based on our study, active- and public-transport commuters are often at risk of higher air pollution and noise exposure than private car users. This should be taken into account in urban transportation planning. Copyright © 2017 Elsevier Inc. All rights reserved.

  12. On Time Delay Margin Estimation for Adaptive Control and Optimal Control Modification

    NASA Technical Reports Server (NTRS)

    Nguyen, Nhan T.

    2011-01-01

    This paper presents methods for estimating time delay margin for adaptive control of input delay systems with almost linear structured uncertainty. The bounded linear stability analysis method seeks to represent an adaptive law by a locally bounded linear approximation within a small time window. The time delay margin of this input delay system represents a local stability measure and is computed analytically by three methods: Pade approximation, Lyapunov-Krasovskii method, and the matrix measure method. These methods are applied to the standard model-reference adaptive control, s-modification adaptive law, and optimal control modification adaptive law. The windowing analysis results in non-unique estimates of the time delay margin since it is dependent on the length of a time window and parameters which vary from one time window to the next. The optimal control modification adaptive law overcomes this limitation in that, as the adaptive gain tends to infinity and if the matched uncertainty is linear, then the closed-loop input delay system tends to a LTI system. A lower bound of the time delay margin of this system can then be estimated uniquely without the need for the windowing analysis. Simulation results demonstrates the feasibility of the bounded linear stability method for time delay margin estimation.

  13. High-Reliability Waveguide Vacuum/Pressure Window

    NASA Technical Reports Server (NTRS)

    Britcliffe, Michael J.; Hanson, Theodore R.; Long, Ezra M.; Montanez, Steven

    2013-01-01

    The NASA Deep Space Network (DSN) uses commercial waveguide windows on the output waveguide of Ka-band (32 GHz) low-noise amplifiers. Mechanical failure of these windows resulted in an unacceptable loss in tracking time. To address this issue, a new Ka-band WR-28 waveguide window has been designed, fabricated, and tested. The window uses a slab of low-loss, low-dielectric constant foam that is bonded into a 1/2-wave-thick waveguide/flange. The foam is a commercially available, rigid, closed-cell polymethacrylimide. It has excellent electrical properties with a dielectric constant of 1.04, and a loss tangent of 0.01. It is relatively strong with a tensile strength of 1 MPa. The material is virtually impermeable to helium. The finished window exhibits a leak rate of less than 3x10(exp -3)cu cm/s with helium. The material is also chemically resistant and can be cleaned with acetone. The window is constructed by fabricating a window body by brazing a short length of WR-28 copper waveguide into a standard rectangular flange, and machining the resulting part to a thickness of 4.6 mm. The foam is machined to a rectangular shape with a dimension of 7.06x3.53 mm. The foam is bonded into the body with a two-part epoxy. After curing, the excess glue and foam are knife-trimmed by hand. The finished window has a loss of less than 0.08 dB (2%) and a return loss of greater than 25 dB at 32 GHz. This meets the requirements for the DSN application. The window is usable for most applications over the entire 26-to-40-GHz waveguide band. The window return loss can be tuned to a required frequency by var y in g the thickness of the window slightly. Most standard waveguide windows use a thin membrane of material bonded into a recess in a waveguide flange, or sandwiched between two flanges with a polymer seal. Designs using the recessed window are prone to mechanical failure over time due to constraints on the dimensions of the recess that allow the bond to fail. Designs using the sandwich method are often permeable to helium, which prohibits the use of helium leak detection. At the time of this reporting, 40 windows have been produced. Twelve are in operation with a combined operating time of over 30,000 hours without a failure.

  14. Air Quality Guide for Ozone

    MedlinePlus

    ... outdoors. Note: If you don't have an air conditioner, staying inside with the windows closed may be dangerous in extremely hot weather. In these cases, seek alternative shelter. Key Facts to Know About Ozone: Ozone in the air we breathe can cause serious health problems, including ...

  15. Secure closure of the tracheal incision after natural orifice transluminal endoscopic surgery with a surgical sealant (CoSeal).

    PubMed

    Liu, Yun-Hen; Wu, Yi-Cheng; Chen, Tzu-Ping; Ko, Po-Jen

    2011-09-01

    To evaluate the effectiveness of surgical sealant (CoSeal) in sealing the tracheal assess sites after transtracheal thoracoscopy. Two dogs underwent transtracheal thoracic exploration and pericardial window creation. The thoracic cavity was approached with flexible bronchoscope through a 9-mm tracheal incision. The pericardial window was performed with a needle knife via the working channel of the bronchoscope, and the tracheal assess site was closed with CoSeal using a rubber catheter. The integrity of tracheal healing was evaluated under positive pressure ventilation. Transtracheal creation of pericardial window and closure of tracheal incision with CoSeal was successfully performed in both dogs. There was no evidence of air leaks from the chest tube during positive pressure ventilation. Autopsy revealed no injury to the mediastinum and intrathoracic structure. Endoscopic closure of tracheal access site of NOTES with CoSeal appears to be a feasible technique.

  16. First Experiences with Kinect v2 Sensor for Close Range 3d Modelling

    NASA Astrophysics Data System (ADS)

    Lachat, E.; Macher, H.; Mittet, M.-A.; Landes, T.; Grussenmeyer, P.

    2015-02-01

    RGB-D cameras, also known as range imaging cameras, are a recent generation of sensors. As they are suitable for measuring distances to objects at high frame rate, such sensors are increasingly used for 3D acquisitions, and more generally for applications in robotics or computer vision. This kind of sensors became popular especially since the Kinect v1 (Microsoft) arrived on the market in November 2010. In July 2014, Windows has released a new sensor, the Kinect for Windows v2 sensor, based on another technology as its first device. However, due to its initial development for video games, the quality assessment of this new device for 3D modelling represents a major investigation axis. In this paper first experiences with Kinect v2 sensor are related, and the ability of close range 3D modelling is investigated. For this purpose, error sources on output data as well as a calibration approach are presented.

  17. Views supporting the Window Experiment (WINDEX) of shuttle environment

    NASA Image and Video Library

    1995-08-03

    STS070-386-027 (13-22 JULY 1995) --- High-speed film provided this close-up view of the Space Shuttle Discovery’s aft, featuring the ignition of one of the primary thrusters. Note the impact of the firing on the starboard side of the vertical stabilizer. Crew members told a August 11, 1995, gathering of Johnson Space Center (JSC) employees that the Window Experiment (WINDEX) paid close attention to surface glow, jet plumes, water dumps, aurora and airglow. The data collection is part of an effort to avoid misinterpretation of measurements of Earth, the solar system and starts taken from satellites in low Earth-orbits and prevent damage to sensitive systems and solar arrays during rendezvous and docking. Such firings of the thrusters increase local densities of gases in the atmosphere dramatically and introduce non-natural elements that react with the atmosphere dramatically and spacecraft systems enveloped by the thruster plume. WINDEX recorded phenomena associated with thruster start-up and shut-down transients and observed the effect of the transients on Shuttle glow phenomenon.

  18. Abduction of children of political dissidents in Argentina and the role of human genetics in their restitution.

    PubMed

    Penchaszadeh, V B

    1992-01-01

    Between 1976 and 1983 a brutal military dictatorship governed Argentina. The most basic human rights were severely violated and the method of forced disappearances of approximately 30,000 political dissidents was instituted. In this process, about 300 babies and children of the disappeared victims were also abducted by the military and given to childless families linked to the security forces. Women whose children and grandchildren had disappeared organized themselves as Grandmothers of Plaza de Mayo to search for their missing loved ones. This search was aided by human geneticists from different parts of the world who provided the scientific basis to establish the genetic identification through "grandpaternity testing," and by mental health professionals who provided the psychological theory supporting restitution of appropriated children to their legitimate families. Thus far, close to 50 children have been located, identified and restituted.

  19. SU-E-T-350: Verification of Gating Performance of a New Elekta Gating Solution: Response Kit and Catalyst System

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Xie, X; Cao, D; Housley, D

    2014-06-01

    Purpose: In this work, we have tested the performance of new respiratory gating solutions for Elekta linacs. These solutions include the Response gating and the C-RAD Catalyst surface mapping system.Verification measurements have been performed for a series of clinical cases. We also examined the beam on latency of the system and its impact on delivery efficiency. Methods: To verify the benefits of tighter gating windows, a Quasar Respiratory Motion Platform was used. Its vertical-motion plate acted as a respiration surrogate and was tracked by the Catalyst system to generate gating signals. A MatriXX ion-chamber array was mounted on its longitudinal-movingmore » platform. Clinical plans are delivered to a stationary and moving Matrix array at 100%, 50% and 30% gating windows and gamma scores were calculated comparing moving delivery results to the stationary result. It is important to note that as one moves to tighter gating windows, the delivery efficiency will be impacted by the linac's beam-on latency. Using a specialized software package, we generated beam-on signals of lengths of 1000ms, 600ms, 450ms, 400ms, 350ms and 300ms. As the gating windows get tighter, one can expect to reach a point where the dose rate will fall to nearly zero, indicating that the gating window is close to beam-on latency. A clinically useful gating window needs to be significantly longer than the latency for the linac. Results: As expected, the use of tighter gating windows improved delivery accuracy. However, a lower limit of the gating window, largely defined by linac beam-on latency, exists at around 300ms. Conclusion: The Response gating kit, combined with the C-RAD Catalyst, provides an effective solution for respiratorygated treatment delivery. Careful patient selection, gating window design, even visual/audio coaching may be necessary to ensure both delivery quality and efficiency. This research project is funded by Elekta.« less

  20. New Mexico's 1998 drive-up liquor window closure. Study II: economic impact on owners.

    PubMed

    Lapham, Sandra C; Skipper, Betty J

    2004-05-01

    This study examined the economic impact of the New Mexico legislative action closing drive-up liquor windows on the retail establishments that operated them. A telephone survey was conducted 20 months after the closure seeking information and owners' opinions about how their outlets had changed since the closure and how this affected their business. In addition, 2 years of aggregated pre- and post-closure total gross receipts revenues were obtained from the New Mexico Taxation and Revenue Department, with convenience stores as a comparison group. Interviews were completed for 149 of 220 establishments. Over one-quarter of former drive-up liquor windows (28%) had been converted to 'step-in' sales, defined as an outside door where customers can stop and enter the premises while their car is running. Almost two-thirds (61%) of owners reported decreased annual gross revenues following closure, with a reported average 15% reduction in alcohol sales. This is consistent with findings of decreased gross receipts for operators of non-urban, but not urban, drive-up liquor windows compared to convenience store gross receipts. Almost three-quarters (72%) of those surveyed would re-open the drive-up window if the law were rescinded. Over one-quarter of the drive-up owners converted to step-in alcohol sales that still allow a form of drive-up liquor sales. Despite this, the forced closure of New Mexico's drive-up liquor windows negatively impacted total sales and liquor sales revenues of establishments that operated them.

  1. Extent of Atypical Hyperplasia Stratifies Breast Cancer Risk in Two Independent Cohorts of Women

    PubMed Central

    Degnim, Amy C.; Dupont, William D.; Radisky, Derek C.; Vierkant, Robert A.; Frank, Ryan D.; Frost, Marlene H.; Winham, Stacey J.; Sanders, Melinda E.; Smith, Jeffrey R.; Page, David L.; Hoskin, Tanya L.; Vachon, Celine M.; Ghosh, Karthik; Hieken, Tina J.; Denison, Lori A.; Carter, Jodi M.; Hartmann, Lynn C.; Visscher, Daniel W.

    2016-01-01

    Background Women with atypical hyperplasia (AH) on breast biopsy have a substantially increased risk of breast cancer (BC). Here we report BC risk with AH extent and subtype in two separate cohorts. Methods All samples containing AH were included from two cohorts of benign breast disease, Mayo Clinic and Nashville. Histology review quantified the number of foci of atypical ductal hyperplasia (ADH) and atypical lobular hyperplasia (ALH). BC risk was stratified for number of AH foci within AH subtypes. Results The study included 708 Mayo and 466 Nashville AH subjects. In the Mayo Cohort, increasing foci of AH was associated with a significant increase in risk of BC, both for ADH (RR’s of 2.61, 5.21, and 6.36 for 1, 2, and 3+ foci, p=0.006 for linear trend) and for ALH (RR’s of 2.56, 3.50, and 6.79 for 1, 2, and 3+ foci, p=0.001 for linear trend). In the Nashville Cohort, RR’s of BC for ADH were 2.70, 5.17, and 15.06 for 1, 2, and 3+ foci respectively (p<0.001 for linear trend); for ALH, RR’s also increased but not significantly (2.61, 3.48, and 4.02, p=0.148). Combining both Mayo and Nashville samples, risk increased significantly for 1, 2, and 3+ foci: RR’s of 2.65, 5.19, and 8.94 for ADH (p<0.001), and 2.58, 3.49, and 4.97 for ALH (p=0.001). Conclusions In two independent cohort studies of benign breast disease, extent of atypia stratifies long-term breast cancer risk for ADH and ALH. PMID:27352219

  2. Association of brain-derived neurotrophic factor (BDNF) Val66Met polymorphism with early-onset bipolar disorder.

    PubMed

    Nassan, Malik; Croarkin, Paul E; Luby, Joan L; Veldic, Marin; Joshi, Paramjit T; McElroy, Susan L; Post, Robert M; Walkup, John T; Cercy, Kelly; Geske, Jennifer R; Wagner, Karen D; Cuellar-Barboza, Alfredo B; Casuto, Leah; Lavebratt, Catharina; Schalling, Martin; Jensen, Peter S; Biernacka, Joanna M; Frye, Mark A

    2015-09-01

    Brain-derived neurotrophic factor (BDNF) Val66Met (rs6265) functional polymorphism has been implicated in early-onset bipolar disorder. However, results of studies are inconsistent. We aimed to further explore this association. DNA samples from the Treatment of Early Age Mania (TEAM) and Mayo Clinic Bipolar Disorder Biobank were investigated for association of rs6265 with early-onset bipolar disorder. Bipolar cases were classified as early onset if the first manic or depressive episode occurred at age ≤19 years (versus adult-onset cases at age >19 years). After quality control, 69 TEAM early-onset bipolar disorder cases, 725 Mayo Clinic bipolar disorder cases (including 189 early-onset cases), and 764 controls were included in the analysis of association, assessed with logistic regression assuming log-additive allele effects. Comparison of TEAM cases with controls suggested association of early-onset bipolar disorder with the rs6265 minor allele [odds ratio (OR) = 1.55, p = 0.04]. Although comparison of early-onset adult bipolar disorder cases from the Mayo Clinic versus controls was not statistically significant, the OR estimate indicated the same direction of effect (OR = 1.21, p = 0.19). When the early-onset TEAM and Mayo Clinic early-onset adult groups were combined and compared with the control group, the association of the minor allele rs6265 was statistically significant (OR = 1.30, p = 0.04). These preliminary analyses of a relatively small sample with early-onset bipolar disorder are suggestive that functional variation in BDNF is implicated in bipolar disorder risk and may have a more significant role in early-onset expression of the disorder. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  3. Vedolizumab induction therapy for inflammatory bowel disease in clinical practice--a nationwide consecutive German cohort study.

    PubMed

    Baumgart, D C; Bokemeyer, B; Drabik, A; Stallmach, A; Schreiber, S

    2016-05-01

    Vedolizumab (VDZ) is a humanised monoclonal IgG1 antibody targeting α4 β7 integrin. To investigate the real-world efficacy of vedolizumab for the treatment of Crohn's disease (CD) and ulcerative colitis (UC). A consecutive cohort of 212 adult IBD patients with active disease (HBI >7/partial Mayo >4) newly receiving VDZ was prospectively recruited from 7 academic and 17 community centres. The primary endpoint was clinical remission (CRM) (CD HBI ≤4, UC pMayo ≤1) in week 14. Secondary endpoints included steroid-free remission (SFCRM), clinical response (CRS) (HBI/pMayo score drop ≥3), vedolizumab impact on CRP, calprotectin and haemoglobin. Data of 97 CD (71.1% female, HBI 11) and 115 UC (42.6% female, pMayo 6) patients were analysed. Only 5.2% CD and 24.3% UC were anti-TNFα naïve. Most had extensive mucosal involvement (Montreal L3 69.1%/E3 53.9%). At week 14, 23.7% vs. 23.5% of CD vs. UC patients achieved CRM, 19.6% vs. 19.1% SFCRM and 60.8% vs. 57.4% CRS, respectively (all based on NRI). Week 14 CRM in CD was significantly associated with no history of extraintestinal manifestations (P = 0.019), no prior adalimumab use (P = 0.011), no hospitalisation in the past 12 months (P = 0.015) and low HBI score (P = 0.02) and in UC with active or previous smoking (P = 0.044/0.028) and no anti-TNFα (P = 0.023) use. Low HBI (P = 0.019) and no hospitalisation in the past 12 months (P = 0.01) predict CD CRM. The three most common AE were joint pain, acne and nasopharyngitis. Vedolizumab is effective in routine use. © 2016 John Wiley & Sons Ltd.

  4. Review of Adjuvant Radiochemotherapy for Resected Pancreatic Cancer and Results From Mayo Clinic for the 5th JUCTS Symposium

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Miller, Robert C.; Iott, Matthew J.; Corsini, Michele M.

    2009-10-01

    Purpose: To present an overview of Phase III trials in adjuvant therapy for pancreatic cancer and review outcomes at the Mayo Clinic after adjuvant radiochemotherapy (RT/CT) for resected pancreatic cancer. Methods and Materials: A literature review and a retrospective review of 472 patients who underwent an R0 resection for T1-3N0-1M0 invasive carcinoma of the pancreas from 1975 to 2005 at the Mayo Clinic, Rochester, MN. Patients with metastatic or unresectable disease at the time of surgery, positive surgical margins, or indolent tumors and those treated with intraoperative radiotherapy were excluded from the analysis. Median radiotherapy dose was 50.4Gy in 28more » fractions, with 98% of patients receiving concurrent 5-fluorouracil- based chemotherapy. Results: Median follow-up was 2.7 years. Median overall survival (OS) was 1.8 years. Median OS after adjuvant RT/CT was 2.1 vs. 1.6 years for surgery alone (p = 0.001). The 2-y OS was 50% vs. 39%, and 5-y was 28% vs. 17% for patients receiving RT/CT vs. surgery alone. Univariate and multivariate analysis revealed that adverse prognostic factors were positive lymph nodes (risk ratio [RR] 1.3, p < 0.001) and high histologic grade (RR 1.2, p < 0.001). T3 tumor status was found significant on univariate analysis only (RR 1.1, p = 0.07). Conclusions: Results from recent clinical trials support the use of adjuvant chemotherapy in resected pancreatic cancer. The role of radiochemotherapy in adjuvant treatment of pancreatic cancer remains a topic of debate. Results from the Mayo Clinic suggest improved outcomes after the administration of adjuvant radiochemotherapy after a complete resection of invasive pancreatic malignancies.« less

  5. NASA/DARPA advanced communications technology satellite project for evaluation of telemedicine outreach using next-generation communications satellite technology: Mayo Foundation participation.

    PubMed

    Gilbert, B K; Mitchell, M P; Bengali, A R; Khandheria, B K

    1999-08-01

    To describe the development of telemedicine capabilities-application of remote consultation and diagnostic techniques-and to evaluate the feasibility and practicality of such clinical outreach to rural and underserved communities with limited telecommunications infrastructures. In 1992, Mayo Foundation (Rochester, Minn, Jacksonville, Fla, and Scottsdale, Ariz), the National Aeronautics and Space Administration, and the Defense Advanced Research Projects Agency collaborated to create a complex network of fiberoptic landlines, video recording systems, satellite terminals, and specially developed data translators linking Mayo sites with other locations in the continental United States on an on-demand basis. The purpose was to transmit data via the asynchronous transfer mode (ATM) digital communications protocol over the Advanced Communications Technology Satellite. The links were intended to provide a conduit for transmission of data for patient-specific consultations between physicians, evaluation of medical imagery, and medical education for clinical staffs at remote sites. Low-data-rate (LDR) experiments went live late in 1993. Mayo Clinic Rochester successfully provided medical consultation and services to 2 small regional medical facilities. High-data-rate (HDR) experiments included studies of remote digital echocardiography, store-and-forward telemedicine, cardiac catheterization, and teleconsultation for congenital heart disease. These studies combined landline data transmission with use of the satellite. The complexity of the routing paths and network components, immaturity of available software, and inexperience with existing telecommunications caused significant study delays. These experiments demonstrated that next-generation satellite technology can provide batch and real-time imagery for telemedicine. The first-generation of the ATM and satellite network technology used in these experiments created several technical problems and inconveniences that should be overcome as the network infrastructure matures.

  6. Utility of the Mayo-Portland adaptability inventory-4 for self-reported outcomes in a military sample with traumatic brain injury.

    PubMed

    Kean, Jacob; Malec, James F; Cooper, Douglas B; Bowles, Amy O

    2013-12-01

    To investigate the psychometric properties of the Mayo-Portland Adaptability Inventory-4 (MPAI-4) obtained by self-report in a large sample of active duty military personnel with traumatic brain injury (TBI). Consecutive cohort who completed the MPAI-4 as a part of a larger battery of clinical outcome measures at the time of intake to an outpatient brain injury clinic. Medical center. Consecutively referred sample of active duty military personnel (N=404) who suffered predominantly mild (n=355), but also moderate (n=37) and severe (n=12), TBI. Not applicable. MPAI-4 RESULTS: Initial factor analysis suggested 2 salient dimensions. In subsequent analysis, the ratio of the first and second eigenvalues (6.84:1) and parallel analysis indicated sufficient unidimensionality in 26 retained items. Iterative Rasch analysis resulted in the rescaling of the measure and the removal of 5 additional items for poor fit. The items of the final 21-item Mayo-Portland Adaptability Inventory-military were locally independent, demonstrated monotonically increasing responses, adequately fit the item response model, and permitted the identification of nearly 5 statistically distinct levels of disability in the study population. Slight mistargeting of the population resulted in the global outcome, as measured by the Mayo-Portland Adaptability Inventory-military, tending to be less reflective of very mild levels of disability. These data collected in a relatively large sample of active duty service members with TBI provide insight into the ability of patients to self-report functional impairment and the distinct effects of military deployment on outcome, providing important guidance for the meaningful measurement of outcome in this population. Copyright © 2013 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved.

  7. The windows of SETI--frequency and time in the search for extraterrestrial intelligence.

    PubMed

    Oliver, B M

    1987-01-01

    On Earth intelligent life evolved as a natural consequence of the events set in motion when the planet formed over 4 billion years ago. Since chemical evolution and solar-system formation appear to be occurring throughout the universe, we theorize that our universe may be rich with planets populated by intelligent beings who, like us, can search for evidence of other technological civilizations. Terrestrial civilization now has this capability. But if we do not begin the search soon, we'll lose the opportunity to do it from Earth as interfering signals of Earthly origin rapidly close the microwave window.

  8. Laser window with annular grooves for thermal isolation

    DOEpatents

    Warner, B.E.; Horton, J.A.; Alger, T.W.

    1983-07-13

    A laser window or other optical element which is thermally loaded, heats up and causes optical distortions because of temperature gradients between the center and the edge. A number of annular grooves, one to three or more, are formed in the element between a central portion and edge portion, producing a web portion which concentrates the thermal gradient and thermally isolates the central portion from the edge portion, producing a uniform temperature profile across the central portion and therefore reduce the optical distortions. The grooves are narrow and closely spaced with respect to the thickness of the element, and successive grooves are formed from alternate sides of the element.

  9. Telescope search for a 3-eV to 8-eV axion

    NASA Technical Reports Server (NTRS)

    Bershady, Matthew A.; Ressell, M. Ted; Turner, Michael S.

    1991-01-01

    Axions of mass 3-8 eV should have a cosmological abundance of about 50/cu cm and reside in rich clusters of galaxies. Their decays to two photons will produce a line at a wavelength of about 3100-8300 A. This effort has searched unsuccessfully for such a feature in the tergalactic light of three rich clusters, closing this 'window', and leaving open only the window from 10 to the -6th to 0.001 eV. This implies that if the axion exists, it likely comprises the dark matter. The present flux limits are of relevance to other relics whose decays produce monoenergetic photons.

  10. Suicidal hanging within an automobile.

    PubMed

    Blanco Pampin, J M; López-Abajo Rodriguez, B A

    2001-12-01

    Accidental asphyxia related to cars has been described in different reports, but suicidal hanging in an automobile is very unusual. Two cases of suicidal hanging inside an automobile are described, illustrating an unusual form of hanging. In one case, the deceased used his belt as a ligature, and the point of attachment was the window of the car. The second victim used the safety belt of the passenger seat. In both cases, the automobile engine was turned off, all the windows were closed, and the door locks were blocked. The medicolegal cause of hanging was based on the scene of the investigation, police and witness reports, social history, autopsy findings, and toxicologic examinations.

  11. Lafora disease offers a unique window into neuronal glycogen metabolism.

    PubMed

    Gentry, Matthew S; Guinovart, Joan J; Minassian, Berge A; Roach, Peter J; Serratosa, Jose M

    2018-05-11

    Lafora disease (LD) is a fatal, autosomal recessive, glycogen-storage disorder that manifests as severe epilepsy. LD results from mutations in the gene encoding either the glycogen phosphatase laforin or the E3 ubiquitin ligase malin. Individuals with LD develop cytoplasmic, aberrant glycogen inclusions in nearly all tissues that more closely resemble plant starch than human glycogen. This Minireview discusses the unique window into glycogen metabolism that LD research offers. It also highlights recent discoveries, including that glycogen contains covalently bound phosphate and that neurons synthesize glycogen and express both glycogen synthase and glycogen phosphorylase. © 2018 by The American Society for Biochemistry and Molecular Biology, Inc.

  12. KSC-03pd0913

    NASA Image and Video Library

    2003-03-29

    KENNEDY SPACE CENTER, FLA. - Workers begin closing the solar panels on the Mars Exploration Rover 2 (MER-2) for flight stow. Set to launch in Spring 2003, the MER Mission will consist of two identical rovers designed to cover roughly 110 yards each Martian day over various terrain. The rovers will be identical to each other, but will land at different regions of Mars. Each rover will carry five scientific instruments that will allow it to search for evidence of liquid water that may have been present in the planet's past. The first rover has a launch window opening May 30, and the second rover a window opening June 25.

  13. KSC-03pd0914

    NASA Image and Video Library

    2003-03-29

    KENNEDY SPACE CENTER, FLA. - After closing the solar panels for flight stow, workers examine the Mars Exploration Rover 2 (MER-2). Set to launch in Spring 2003, the MER Mission will consist of two identical rovers designed to cover roughly 110 yards each Martian day over various terrain. The rovers will be identical to each other, but will land at different regions of Mars. Each rover will carry five scientific instruments that will allow it to search for evidence of liquid water that may have been present in the planet's past. The first rover has a launch window opening May 30, and the second rover a window opening June 25.

  14. Mechanisms of Cochlear Stimulation Through the Round Window

    NASA Astrophysics Data System (ADS)

    Lukashkin, Andrei N.; Weddell, Thomas; Russell, Ian J.

    2011-11-01

    The round window membrane (RW) functions as a pressure relief valve in conventional hearing allowing structures of the middle ear to move. Investigations in recent years have shown that middle ear implants can be used to stimulate the cochlea via the RW. Isolated clinical uses of this technique have been applied but more thorough theoretical and empirical studies are required. Using guinea pigs as test subjects we have investigated physiological effects of RW stimulation using a simulation of active middle ear prosthesis, a cylindrical neodymium iron boron disk magnet placed upon the RW which can be stimulated by an electromagnetic coil positioned in close proximity to the magnet.

  15. Frequency of open windows in motor vehicles under varying temperature conditions: a videotape survey in Central North Carolina during 2001.

    PubMed

    Long, Tom; Johnson, Ted; Ollison, Will

    2004-07-01

    Air pollution exposures in the motor vehicle cabin are significantly affected by air exchange rate, a function of vehicle speed, window position, vent status, fan speed, and air conditioning use. A pilot study conducted in Houston, Texas, during September 2000 demonstrated that useful information concerning the position of windows, sunroofs, and convertible tops as a function of temperature and vehicle speed could be obtained through the use of video recorders. To obtain similar data representing a wide range of temperature and traffic conditions, a follow-up study was conducted in and around Chapel Hill, North Carolina at five sites representing a central business district, an arterial road, a low-income commercial district, an interstate highway, and a rural road. Each site permitted an elevated view of vehicles as they proceeded through a turn, thereby exposing all windows to the stationary camcorder. A total of 32 videotaping sessions were conducted between February and October 2001, in which temperature varied from 41 degrees F to 93 degrees F and average vehicle speed varied from 21 to 77 mph. The resulting video tapes were processed to create a vehicle-specific database that included site location, date, time, vehicle type, vehicle color, vehicle age, window configuration, number of windows in each of three position categories (fully open, partially open, and closed), meteorological factors, and vehicle speed. Of the 4715 vehicles included in the database, 1905 (40.4%) were labeled as "open," indicating a window, sunroof, or convertible top was fully or partially open. Stepwise linear regression analyses indicated that "open" window status was affected by wind speed, relative humidity, vehicle speed, cloud cover, apparent temperature, day of week, time of day, vehicle type, vehicle age, vehicle color, number of windows, sunroofs, location, and air quality season. Open windows tended to occur less frequently when relative humidity was high, apparent temperature (a parameter incorporating wind chill and heat index) was below 50 degrees F, or the vehicle was relatively new. Although the effects of the identified parameters were relatively weak, they are statistically significant and should be considered by researchers attempting to model vehicle air exchange rates.

  16. Thermal damage study of beryllium windows used as vacuum barriers in synchrotron radiation beamlines

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Holdener, F.R.; Johnson, G.L.; Karpenko, V.P.

    An experimental study to investigate thermal-induced damage to SSRL-designed beryllium foil windows was performed at LLNL's Laser Welding Research Facility. The primary goal of this study was to determine the threshold at which thermal-stress-induced damage occurs in these commonly used vacuum barriers. An Nd:Yag pulsed laser with cylindrical optics and a carefully designed test cell provided a test environment that closely resembles the actual beamline conditions at SSRL. Tests performed on two beryllium window geometries, with different vertical aperture dimensions but equal foil thicknesses of 0.254 mm, resulted in two focused total-power thresholds at which incipient damage was determined. Formore » a beam spot size similar to that of the Beamline-X Wiggler Line, onset of surface damage for a 5-mm by 25-mm aperture window was observed at 170 W after 174,000 laser pulses (1.2-ms pulse at 100 pps). A second window with double the vertical aperture dimension (10 mm by 25 mm) was observed to have surface cracking after 180,000 laser pulses with 85 W impinging its front surface. It failed after approximately 1,000,000 pulses. Another window of the same type (10 mm by 25 mm) received 2,160,000 laser pulses at 74.4 W, and subsequent metallographic sectioning revealed no signs of through-thickness damage. Comparison of windows with equal foil thicknesses and aperture dimensions has effectively identified the heat flux limit for incipient failure. The data show that halving the aperture's vertical dimension allows doubling the total incident power for equivalent onsets of thermal-induced damage.« less

  17. Bringing human resources to the table: utilization of an HR balanced scorecard at Mayo Clinic.

    PubMed

    Fottler, Myron D; Erickson, Eric; Rivers, Patrick A

    2006-01-01

    Rather than viewing HR as a critical driver of organizational strategy and outcomes, most health care organizations see HR as a drain on the organization's bottom line. Only by aligning HR with the organizational strategy will HR leaders truly get a seat at the leadership table. HR professionals can overcome impediments and gain a seat at the table by learning the language of business and the ways in which organizational leaders use data to drive their decisions. This article shows how Mayo Clinic uses the popular Balanced Scorecard approach to align its measures of HR performance to the organization's strategic plan.

  18. Clinical Features, Etiologic Factors, Associated Disorders, and Treatment of Palmoplantar Pustulosis: The Mayo Clinic Experience, 1996-2013.

    PubMed

    Olazagasti, Jeannette M; Ma, Janice E; Wetter, David A

    2017-09-01

    To further characterize clinical characteristics, etiologic factors, associated disorders, and treatment of palmoplantar pustulosis (PPP). We conducted a retrospective review of patients with PPP at Mayo Clinic between January 1, 1996, and December 31, 2013. Of 215 patients with PPP identified, 179 (83%) were female, and the mean age at onset was 45.3 years. Most patients (n=165, 77%) were current or former smokers. At diagnosis, 15 patients (7%) had an anxiety diagnosis and 9 (4%) had an infection. Nineteen cases (9%) were drug induced. Comorbid conditions included thyroid disease in 18 patients (8%), gluten sensitivity in 3 (1%), and type 2 diabetes mellitus in 21 (10%). In all, 194 patients (90%) received topical corticosteroids, 55 (26%) received phototherapy, and 54 (25%) received systemic agents. More than three-fourths of the patients in this study had a history of smoking, which is considered a triggering or aggravating factor for PPP. Regarding comorbid conditions, gluten sensitivity and thyroid disease were found less frequently than previously reported in the literature. Treatment regimens and responses in this cohort varied considerably. Copyright © 2017 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc. All rights reserved.

  19. Prognostic significance of interventricular septal thickness in patients with AL amyloidosis.

    PubMed

    Cho, Hyunsoo; Kim, Soo-Jeong; Shim, Chi Young; Hong, Geu-Ru; Ha, Jong-Won; Kim, Yu Ri; Yang, Woo Ick; Chung, Haerim; Jang, Ji Eun; Cheong, June-Won; Min, Yoo Hong; Kim, Jin Seok

    2017-09-01

    The major prognostic determinant of immunoglobulin light chain (AL) amyloidosis is cardiac involvement. However, the role of interventricular septal thickness (IVST), which reflects the extent of cardiac involvement, remains unclear. Therefore, we analyzed 77 patients with newly diagnosed AL amyloidosis and evaluated the prognostic role of IVST. Fifty patients (64.9%) had cardiac involvement and 17 patients (22.1%) showed IVST >15mm. Among all patients, the revised Mayo Clinic Stage III-IV and IVST >15mm were independently associated with inferior overall survival (OS) in a multivariable analysis. IVST >15mm was also adversely prognostic for OS in a subgroup of advanced-stage (revised Mayo Clinic stage III-IV) patients in a multivariable analysis (P<0.001). Furthermore, advanced-stage patients with IVST >15mm did not show survival benefit from treatment with bortezomib-based regimens and/or autologous stem-cell transplantation (ASCT). Our study demonstrated that IVST >15mm is adversely prognostic independent of the revised Mayo Clinic staging system in patients with AL amyloidosis. In addition, the degree of IVST might be used as a useful prognostic indicator that can guide the management of patients with AL amyloidosis especially at an advanced stage. Copyright © 2017 Elsevier Ltd. All rights reserved.

  20. Gist: A scientific graphics package for Python

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Busby, L.E.

    1996-05-08

    {open_quotes}Gist{close_quotes} is a scientific graphics library written by David H. Munro of Lawrence Livermore National Laboratory (LLNL). It features support for three common graphics output devices: X Windows, (Color) PostScript, and ANSI/ISO Standard Computer Graphics Metafiles (CGM). The library is small (written directly to Xlib), portable, efficient, and full-featured. It produces X versus Y plots with {open_quotes}good{close_quotes} tick marks and tick labels, 2-dimensional quadrilateral mesh plots with contours, vector fields, or pseudo color maps on such meshes, with 3-dimensional plots on the way. The Python Gist module utilizes the new {open_quotes}Numeric{close_quotes} module due to J. Hugunin and others. It ismore » therefore fast and able to handle large datasets. The Gist module includes an X Windows event dispatcher which can be dynamically added (e.g., via importing a dynamically loaded module) to the Python interpreter after a simple two-line modification to the Python core. This makes fast mouse-controlled zoom, pan, and other graphic operations available to the researcher while maintaining the usual Python command-line interface. Munro`s Gist library is already freely available. The Python Gist module is currently under review and is also expected to qualify for unlimited release.« less

  1. 30 CFR 18.6 - Applications.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... metal and not have a compartment exceeding ten (10) feet in length. Glass or polycarbonate materials... polycarbonate windows and lenses shall not exceed 115 °C (240 °F), in normal operation. Other non-metallic... metallic conduit are not permitted. (H) Unused lead entrances shall be closed with a metal plug that is...

  2. 30 CFR 18.6 - Applications.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... metal and not have a compartment exceeding ten (10) feet in length. Glass or polycarbonate materials... polycarbonate windows and lenses shall not exceed 115 °C (240 °F), in normal operation. Other non-metallic... metallic conduit are not permitted. (H) Unused lead entrances shall be closed with a metal plug that is...

  3. 30 CFR 18.6 - Applications.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... metal and not have a compartment exceeding ten (10) feet in length. Glass or polycarbonate materials... polycarbonate windows and lenses shall not exceed 115 °C (240 °F), in normal operation. Other non-metallic... metallic conduit are not permitted. (H) Unused lead entrances shall be closed with a metal plug that is...

  4. 30 CFR 18.6 - Applications.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... metal and not have a compartment exceeding ten (10) feet in length. Glass or polycarbonate materials... polycarbonate windows and lenses shall not exceed 115 °C (240 °F), in normal operation. Other non-metallic... metallic conduit are not permitted. (H) Unused lead entrances shall be closed with a metal plug that is...

  5. 30 CFR 18.6 - Applications.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... metal and not have a compartment exceeding ten (10) feet in length. Glass or polycarbonate materials... polycarbonate windows and lenses shall not exceed 115 °C (240 °F), in normal operation. Other non-metallic... metallic conduit are not permitted. (H) Unused lead entrances shall be closed with a metal plug that is...

  6. Simple and effective method to lock buoy position to ocean currents

    NASA Technical Reports Server (NTRS)

    Vachon, W. A.; Dahlen, J. M.

    1975-01-01

    Window-shade drogue, used with drifting buoys to keep them moving with current at speed as close to that of current as possible, has drag coefficient of 1.93 compared to maximum of 1.52 for previous drogues. It is remarkably simple to construct, use, and store.

  7. A Coherent VLSI Design Environment.

    DTIC Science & Technology

    1985-09-30

    deviation were only a few percent. If the number of paths with a delay close to 9ns were large, even more statistical accuracy would be required to...Zippel, 1Capsules, IGPLAN Bulletn, vol. 18, no. 6, waveforms. In the bottom window, the currents into the pp. 164-169, 1983. depletion transitors are

  8. Location identification of closed crack based on Duffing oscillator transient transition

    NASA Astrophysics Data System (ADS)

    Liu, Xiaofeng; Bo, Lin; Liu, Yaolu; Zhao, Youxuan; Zhang, Jun; Deng, Mingxi; Hu, Ning

    2018-02-01

    The existence of a closed micro-crack in plates can be detected by using the nonlinear harmonic characteristics of the Lamb wave. However, its location identification is difficult. By considering the transient nonlinear Lamb under the noise interference, we proposed a location identification method for the closed crack based on the quantitative measurement of Duffing oscillator transient transfer in the phase space. The sliding short-time window was used to create a window truncation of to-be-detected signal. And then, the periodic extension processing for transient nonlinear Lamb wave was performed to ensure that the Duffing oscillator has adequate response time to reach a steady state. The transient autocorrelation method was used to reduce the occurrence of missed harmonic detection due to the random variable phase of nonlinear Lamb wave. Moreover, to overcome the deficiency in the quantitative analysis of Duffing system state by phase trajectory diagram and eliminate the misjudgment caused by harmonic frequency component contained in broadband noise, logic operation method of oscillator state transition function based on circular zone partition was adopted to establish the mapping relation between the oscillator transition state and the nonlinear harmonic time domain information. Final state transition discriminant function of Duffing oscillator was used as basis for identifying the reflected and transmitted harmonics from the crack. Chirplet time-frequency analysis was conducted to identify the mode of generated harmonics and determine the propagation speed. Through these steps, accurate position identification of the closed crack was achieved.

  9. How does ulnar shortening osteotomy influence morphologic changes in the triangular fibrocartilage complex?

    PubMed

    Yamanaka, Yoshiaki; Nakamura, Toshiyasu; Sato, Kazuki; Toyama, Yoshiaki

    2014-11-01

    Ulnar shortening osteotomy often is indicated for treatment of injuries to the triangular fibrocartilage complex (TFCC). However, the effect of ulnar shortening osteotomy on the changes in shape of the TFCC is unclear. In our study, quantitative evaluations were performed using MRI to clarify the effect of ulnar shortening on triangular fibrocartilage (TFC) thickness attributable to disc regeneration of the TFC and TFC angle attributable to the suspension effect of ulnar shortening on the TFC. The purposes of this study were (1) to compare preoperative and postoperative TFC thickness and TFC angle on MR images to quantitatively evaluate the effect of ulnar shortening osteotomy on disc regeneration and the suspension effect on the TFC; and (2) to assess whether changes in TFC thickness and TFC angle correlated with the Mayo wrist score. Between 1995 and 2008, 256 patients underwent ulnar shortening osteotomy for TFCC injuries. The minimum followup was 24 months (mean, 51 months; range, 24-210 months). A total of 79 patients (31%) with complete followup including preoperative and postoperative MR images and the Mayo wrist score was included in this retrospective study. Evaluation of the postoperative MR images and the Mayo wrist score were performed at the final followup. The remaining 177 patients did not undergo postoperative MRI, or they had a previous fracture, large tears of the disc proper, or were lost to followup. Two orthopaedists, one of whom performed the surgeries, measured the TFC thickness and the TFC angle on coronal MR images before and after surgery for each patient. Correlations of the percent change in the TFC thickness and the magnitude of TFC angle change with age, sex, postoperative MR images, extent of ulnar shortening, preoperative ulnar variance, and postoperative Mayo wrist score were assessed. Stepwise regression analysis showed a correlation between the percent change in TFC thickness and preoperative ulnar variance (R2=0.21; β=-0.33; 95% CI, -0.11 to 0.01; p=0.01) and between the magnitude of change in the TFC angle and the extent of ulnar shortening (R2=0.18; β=-0.29; 95% CI, -5.8 to 0.29; p=0.03). The Mayo wrist score was not correlated with the percent change in TFC thickness or the magnitude of change in the TFC angle. These results suggest that, in patients with TFCC injury with a smaller preoperative ulnar variance, a high residual potential for regeneration in the disc proper was seen after ulnar shortening osteotomy, and correlated with the extent of ulnar shortening and the suspension effect on TFC. However, there was no correlation between disc regeneration or the suspension effect on TFC and the Mayo wrist score. Level IV, therapeutic study. See the Instructions for Authors for a complete description of levels of evidence.

  10. Plan averaging for multicriteria navigation of sliding window IMRT and VMAT

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Craft, David, E-mail: dcraft@partners.org; Papp, Dávid; Unkelbach, Jan

    2014-02-15

    Purpose: To describe a method for combining sliding window plans [intensity modulated radiation therapy (IMRT) or volumetric modulated arc therapy (VMAT)] for use in treatment plan averaging, which is needed for Pareto surface navigation based multicriteria treatment planning. Methods: The authors show that by taking an appropriately defined average of leaf trajectories of sliding window plans, the authors obtain a sliding window plan whose fluence map is the exact average of the fluence maps corresponding to the initial plans. In the case of static-beam IMRT, this also implies that the dose distribution of the averaged plan is the exact dosimetricmore » average of the initial plans. In VMAT delivery, the dose distribution of the averaged plan is a close approximation of the dosimetric average of the initial plans. Results: The authors demonstrate the method on three Pareto optimal VMAT plans created for a demanding paraspinal case, where the tumor surrounds the spinal cord. The results show that the leaf averaged plans yield dose distributions that approximate the dosimetric averages of the precomputed Pareto optimal plans well. Conclusions: The proposed method enables the navigation of deliverable Pareto optimal plans directly, i.e., interactive multicriteria exploration of deliverable sliding window IMRT and VMAT plans, eliminating the need for a sequencing step after navigation and hence the dose degradation that is caused by such a sequencing step.« less

  11. Sensitivity and Specificity of Emergency Physicians and Trainees for Identifying Internally Concealed Drug Packages on Abdominal Computed Tomography Scan: Do Lung Windows Improve Accuracy?

    PubMed

    Asha, Stephen Edward; Cooke, Andrew

    2015-09-01

    Suspected body packers may be brought to emergency departments (EDs) close to international airports for abdominal computed tomography (CT) scanning. Senior emergency clinicians may be asked to interpret these CT scans. Missing concealed drug packages have important clinical and forensic implications. The accuracy of emergency clinician interpretation of abdominal CT scans for concealed drugs is not known. Limited evidence suggests that accuracy for identification of concealed packages can be increased by viewing CT images on "lung window" settings. To determine the accuracy of senior emergency clinicians in interpreting abdominal CT scans for concealed drugs, and to determine if this accuracy was improved by viewing scans on both abdominal and lung window settings. Emergency clinicians blinded to all patient identifiers and the radiology report interpreted CT scans of suspected body packers using standard abdominal window settings and then with the addition of lung window settings. The reference standard was the radiologist's report. Fifty-five emergency clinicians reported 235 CT scans. The sensitivity, specificity, and accuracy of interpretation using abdominal windows was 89.9% (95% confidence interval [CI] 83.0-94.7), 81.9% (95% CI 73.7-88.4), and 86.0% (95% CI 81.5-90.4), respectively, and with both window settings was 94.1% (95% CI 88.3-97.6), 76.7% (95% CI 68.0-84.1), 85.5% (95% CI 81.0-90.0), respectively. Diagnostic accuracy was similar regardless of the clinician's experience. Interrater reliability was moderate (kappa 0.46). The accuracy of interpretation of abdominal CT scans performed for the purpose of detecting concealed drug packages by emergency clinicians is not high enough to safely discharge these patients from the ED. The use of lung windows improved sensitivity, but at the expense of specificity. Crown Copyright © 2015. Published by Elsevier Inc. All rights reserved.

  12. Towards component-based validation of GATE: aspects of the coincidence processor

    PubMed Central

    Moraes, Eder R.; Poon, Jonathan K.; Balakrishnan, Karthikayan; Wang, Wenli; Badawi, Ramsey D.

    2014-01-01

    GATE is public domain software widely used for Monte Carlo simulation in emission tomography. Validations of GATE have primarily been performed on a whole-system basis, leaving the possibility that errors in one sub-system may be offset by errors in others. We assess the accuracy of the GATE PET coincidence generation sub-system in isolation, focusing on the options most closely modeling the majority of commercially available scanners. Independent coincidence generators were coded by teams at Toshiba Medical Research Unit (TMRU) and UC Davis. A model similar to the Siemens mCT scanner was created in GATE. Annihilation photons interacting with the detectors were recorded. Coincidences were generated using GATE, TMRU and UC Davis code and results compared to “ground truth” obtained from the history of the photon interactions. GATE was tested twice, once with every qualified single event opening a time window and initiating a coincidence check (the “multiple window method”), and once where a time window is opened and a coincidence check initiated only by the first single event to occur after the end of the prior time window (the “single window method”). True, scattered and random coincidences were compared. Noise equivalent count rates were also computed and compared. The TMRU and UC Davis coincidence generators agree well with ground truth. With GATE, reasonable accuracy can be obtained if the single window method option is chosen and random coincidences are estimated without use of the delayed coincidence option. However in this GATE version, other parameter combinations can result in significant errors. PMID:25240897

  13. Measuring and modeling air exchange rates inside taxi cabs in Los Angeles, California

    NASA Astrophysics Data System (ADS)

    Shu, Shi; Yu, Nu; Wang, Yueyan; Zhu, Yifang

    2015-12-01

    Air exchange rates (AERs) have a direct impact on traffic-related air pollutant (TRAP) levels inside vehicles. Taxi drivers are occupationally exposed to TRAP on a daily basis, yet there is limited measurement of AERs in taxi cabs. To fill this gap, AERs were quantified in 22 representative Los Angeles taxi cabs including 10 Prius, 5 Crown Victoria, 3 Camry, 3 Caravan, and 1 Uplander under realistic driving (RD) conditions. To further study the impacts of window position and ventilation settings on taxi AERs, additional tests were conducted on 14 taxis with windows closed (WC) and on the other 8 taxis with not only windows closed but also medium fan speed (WC-MFS) under outdoor air mode. Under RD conditions, the AERs in all 22 cabs had a mean of 63 h-1 with a median of 38 h-1. Similar AERs were observed under WC condition when compared to those measured under RD condition. Under WC-MFS condition, AERs were significantly increased in all taxi cabs, when compared with those measured under RD condition. A General Estimating Equation (GEE) model was developed and the modeling results showed that vehicle model was a significant factor in determining the AERs in taxi cabs under RD condition. Driving speed and car age were positively associated with AERs but not statistically significant. Overall, AERs measured in taxi cabs were much higher than typical AERs people usually encounter in indoor environments such as homes, offices, and even regular passenger vehicles.

  14. Maxillary sinus augmentation with a sonic handpiece for the osteotomy of the lateral window: a clinical report.

    PubMed

    Geminiani, Alessandro; Papadimitriou, Dimitrios E V; Ercoli, Carlo

    2011-11-01

    Several techniques have been proposed to manage patients with insufficient bone height for implant placement in the posterior maxilla. The lateral approach to sinus elevation is a successful procedure, with percentages of success close to 100%. Unfortunately, a frequent complication encountered during sinus elevation procedure is perforation of the Schneiderian membrane. In this clinical report, the authors present the application of a diamond coated sonic tip and an air-driven sonic instrument, commonly used in prosthodontics for the preparation of the lateral window osteotomy during sinus augmentation procedures. Copyright © 2011 The Editorial Council of the Journal of Prosthetic Dentistry. Published by Mosby, Inc. All rights reserved.

  15. Putting the pieces together: a crystal clear window into CLC anion channel regulation.

    PubMed

    Strange, Kevin

    2011-01-01

    CLC anion transport proteins function as Cl (-) channels and Cl (-) /H (+) exchangers and are found in all major groups of life including archaebacteria. Early electrophysiological studies suggested that CLC anion channels have two pores that are opened and closed independently by a "fast" gating process operating on a millisecond timescale, and a "common" or "slow" gate that opens and closes both pores simultaneously with a timescale of seconds (Figure 1A). Subsequent biochemical and molecular experiments suggested that CLC channels/transporters are homodomeric proteins ( 1-3) .

  16. The conversion to electronic hospital notes at Mayo Clinic. Overcoming barriers and challenges.

    PubMed

    Andreen, Debra L; Dobie, Linda J; Jasperson, Jan C; Lucas, Thomas A; Wubbenhorst, Cathryn L

    2010-01-01

    This article describes the conversion to electronic hospital notes at a large, multi-specialty group practice: Mayo Clinic in Rochester, Minnesota. Because of the size of the institution and the barriers to the adoption of electronic notes, the process was a gradual one that took several years. Making a convincing case for change to institutional leaders and maintaining their support was crucial to success. Equally vital was the careful investigation of user requirements and the development of software features that allowed providers to complete their notes quickly in the fast-paced hospital environment. Care providers discovered the value of having immediate access to legible hospital notes throughout the campus and from remote locations.

  17. Implementation of a care management model for depression at two primary care clinics.

    PubMed

    Williams, Mark; Angstman, Kurt; Johnson, Isaac; Katzelnick, David

    2011-01-01

    The Mayo clinic participated in the Depression Improvement Across Minnesota, Offering a New Direction model at two Mayo Family Clinics, that is, the Rochester Northwest and Northeast sites. Although the Northwest and Northeast clinics demonstrated the best 6-month remission rates in the state during the first year of implementation, they were retrospectively found to differ on several process issues and on measures related to the populations served. Six-month remission rates were significantly better at Northwest clinic; yet, Northeast clinic had more patient contacts. Differences in rates of activation into care management, care management accessibility, and differences in maintaining contact with patients at 6 months may explain some of these results.

  18. Who's Zooming Whom? Attunement to Animation in the Interface.

    ERIC Educational Resources Information Center

    Chui, Michael; Dillon, Andrew

    1997-01-01

    Two controlled experiments examined whether the animated zooming effect accompanying the opening or closing of a folder in the Apple Macintosh graphical user interface aids in the user's perception of which window corresponds to which folder. Results suggest users may become attuned to the informational content of the zooming effect with…

  19. Do Examinations Influence Student Evaluations?

    ERIC Educational Resources Information Center

    Arnold, Ivo J. M.

    2009-01-01

    This paper measures the impact of timing on student evaluations of teaching effectiveness, using a dataset of close to 3000 observations from Erasmus School of Economics. A special feature of the data is that students were able to complete on-line questionnaires during a time window ranging from one week "before" to one week "after" the final…

  20. Barratt closes Crew Lock of the A/L during EVA-3 Preparation

    NASA Image and Video Library

    2009-07-22

    S127-E-007704 (22 July 2009) --- Astronaut Mike Barratt, Expedition 20 flight engineer, looks at astronaut Dave Wolf through the hatch window just after "sending off" astronauts Wolf and Christopher Cassidy (out of frame) for Endeavour's third space walk of a scheduled five overall for this flight.

  1. Through the Bugscope

    ERIC Educational Resources Information Center

    Hadley, Kathryn; Korb, Michele

    2007-01-01

    The projection screen in the dimly lit auditorium was ready and an online chat window was open on the computer screen. Computer experts and entomologists were ready on the other end. One by one, students filled up the rows of seats eagerly anticipating what was going to happen next. Each student was asked to close their eyes. Ms. Hadley asked…

  2. Equity and Excellence in Education Reform: An Unfinished Agenda.

    ERIC Educational Resources Information Center

    Sadker, Myra; Sadker, David

    This paper argues that the recent wave of school reform literature has neglected females, thereby threatening to close already narrowing windows of opportunity for their advanced education beyond high school. A line-by-line content analysis of 138 articles on educational reform published in nine influential professional journals between 1983 and…

  3. Software Review: A program for testing capture-recapture data for closure

    USGS Publications Warehouse

    Stanley, Thomas R.; Richards, Jon D.

    2005-01-01

    Capture-recapture methods are widely used to estimate population parameters of free-ranging animals. Closed-population capture-recapture models, which assume there are no additions to or losses from the population over the period of study (i.e., the closure assumption), are preferred for population estimation over the open-population models, which do not assume closure, because heterogeneity in detection probabilities can be accounted for and this improves estimates. In this paper we introduce CloseTest, a new Microsoft® Windows-based program that computes the Otis et al. (1978) and Stanley and Burnham (1999) closure tests for capture-recapture data sets. Information on CloseTest features and where to obtain the program are provided.

  4. Complete wavelength mismatching effect in a Doppler broadened Y-type six-level EIT atomic medium

    NASA Astrophysics Data System (ADS)

    Bharti, Vineet; Wasan, Ajay

    We present a theoretical study of the Doppler broadened Y-type six-level atomic system, using a density matrix approach, to investigate the effect of varying control field wavelengths and closely spaced hyperfine levels in the 5P state of 87Rb. The closely spaced hyperfine levels in our six-level system affect the optical properties of Y-type system and cause asymmetry in absorption profiles. Depending upon the choices of π-probe, σ+-control and σ--control fields transitions, we consider three regimes: (i) perfect wavelength matching regime (λp=λ=λ), (ii) partial wavelength mismatching regime (λp≠λ=λ), and (iii) complete wavelength mismatching regime (λp≠λ≠λ). The complete wavelength mismatching regime is further distinguished into two situations, i.e., λ<λ and λ>λ. We have shown that in the room temperature atomic vapor, the asymmetric transparency window gets broadened in the partial wavelength mismatching regime as compared to the perfect wavelength matching regime. This broad transparency window also splits at the line center in the complete wavelength mismatching regime.

  5. Multiple capillary biochemical analyzer with barrier member

    DOEpatents

    Dovichi, N.J.; Zhang, J.Z.

    1996-10-22

    A multiple capillary biochemical analyzer is disclosed for sequencing DNA and performing other analyses, in which a set of capillaries extends from wells in a microtiter plate into a cuvette. In the cuvette the capillaries are held on fixed closely spaced centers by passing through a sandwich construction having a pair of metal shims which squeeze between them a rubber gasket, forming a leak proof seal for an interior chamber in which the capillary ends are positioned. Sheath fluid enters the chamber and entrains filament sample streams from the capillaries. The filament sample streams, and sheath fluid, flow through aligned holes in a barrier member spaced close to the capillary ends, into a collection chamber having a lower glass window. The filament streams are illuminated above the barrier member by a laser, causing them to fluoresce. The fluorescence is viewed end-on by a CCD camera chip located below the glass window. The arrangement ensures an equal optical path length from all fluorescing spots to the CCD chip and also blocks scattered fluorescence illumination, providing more uniform results and an improved signal-to-noise ratio. 12 figs.

  6. Multiple capillary biochemical analyzer with barrier member

    DOEpatents

    Dovichi, Norman J.; Zhang, Jian Z.

    1996-01-01

    A multiple capillary biochemical analyzer for sequencing DNA and performing other analyses, in which a set of capillaries extends from wells in a microtiter plate into a cuvette. In the cuvette the capillaries are held on fixed closely spaced centers by passing through a sandwich construction having a pair of metal shims which squeeze between them a rubber gasket, forming a leak proof seal for an interior chamber in which the capillary ends are positioned. Sheath fluid enters the chamber and entrains filament sample streams from the capillaries. The filament sample streams, and sheath fluid, flow through aligned holes in a barrier member spaced close to the capillary ends, into a collection chamber having a lower glass window. The filament streams are illuminated above the barrier member by a laser, causing them to fluoresce. The fluorescence is viewed end-on by a CCD camera chip located below the glass window. The arrangement ensures an equal optical path length from all fluorescing spots to the CCD chip and also blocks scattered fluorescence illumination, providing more uniform results and an improved signal to noise ratio.

  7. Solving Capacitated Closed Vehicle Routing Problem with Time Windows (CCVRPTW) using BRKGA with local search

    NASA Astrophysics Data System (ADS)

    Prasetyo, H.; Alfatsani, M. A.; Fauza, G.

    2018-05-01

    The main issue in vehicle routing problem (VRP) is finding the shortest route of product distribution from the depot to outlets to minimize total cost of distribution. Capacitated Closed Vehicle Routing Problem with Time Windows (CCVRPTW) is one of the variants of VRP that accommodates vehicle capacity and distribution period. Since the main problem of CCVRPTW is considered a non-polynomial hard (NP-hard) problem, it requires an efficient and effective algorithm to solve the problem. This study was aimed to develop Biased Random Key Genetic Algorithm (BRKGA) that is combined with local search to solve the problem of CCVRPTW. The algorithm design was then coded by MATLAB. Using numerical test, optimum algorithm parameters were set and compared with the heuristic method and Standard BRKGA to solve a case study on soft drink distribution. Results showed that BRKGA combined with local search resulted in lower total distribution cost compared with the heuristic method. Moreover, the developed algorithm was found to be successful in increasing the performance of Standard BRKGA.

  8. A pilot study using scripted ventilation conditions to identify key factors affecting indoor pollutant concentration and air exchange rate in a residence.

    PubMed

    Johnson, Ted; Myers, Jeffrey; Kelly, Thomas; Wisbith, Anthony; Ollison, Will

    2004-01-01

    A pilot study was conducted using an occupied, single-family test house in Columbus, OH, to determine whether a script-based protocol could be used to obtain data useful in identifying the key factors affecting air-exchange rate (AER) and the relationship between indoor and outdoor concentrations of selected traffic-related air pollutants. The test script called for hourly changes to elements of the test house considered likely to influence air flow and AER, including the position (open or closed) of each window and door and the operation (on/off) of the furnace, air conditioner, and ceiling fans. The script was implemented over a 3-day period (January 30-February 1, 2002) during which technicians collected hourly-average data for AER, indoor, and outdoor air concentrations for six pollutants (benzene, formaldehyde (HCHO), polycyclic aromatic hydrocarbons (PAH), carbon monoxide (CO), nitric oxide (NO), and nitrogen oxides (NO(x))), and selected meteorological variables. Consistent with expectations, AER tended to increase with the number of open exterior windows and doors. The 39 AER values measured during the study when all exterior doors and windows were closed varied from 0.36 to 2.29 h(-1) with a geometric mean (GM) of 0.77 h(-1) and a geometric standard deviation (GSD) of 1.435. The 27 AER values measured when at least one exterior door or window was opened varied from 0.50 to 15.8 h(-1) with a GM of 1.98 h(-1) and a GSD of 1.902. AER was also affected by temperature and wind speed, most noticeably when exterior windows and doors were closed. Results of a series of stepwise linear regression analyses suggest that (1) outdoor pollutant concentration and (2) indoor pollutant concentration during the preceding hour were the "variables of choice" for predicting indoor pollutant concentration in the test house under the conditions of this study. Depending on the pollutant and ventilation conditions, one or more of the following variables produced a small, but significant increase in the explained variance (R(2)-value) of the regression equations: AER, number and location of apertures, wind speed, air-conditioning operation, indoor temperature, outdoor temperature, and relative humidity. The indoor concentrations of CO, PAH, NO, and NO(x) were highly correlated with the corresponding outdoor concentrations. The indoor benzene concentrations showed only moderate correlation with outdoor benzene levels, possibly due to a weak indoor source. Indoor formaldehyde concentrations always exceeded outdoor levels, and the correlation between indoor and outdoor concentrations was not statistically significant, indicating the presence of a strong indoor source.

  9. Carbon Nanofiber Nanoelectrodes for Neural Stimulation and Chemical Detection: The Era of "Smart" Deep Brain Stimulation

    NASA Technical Reports Server (NTRS)

    Koehne, Jessica E.

    2016-01-01

    A sensor platform based on vertically aligned carbon nanofibers (CNFs) has been developed. Their inherent nanometer scale, high conductivity, wide potential window, good biocompatibility and well-defined surface chemistry make them ideal candidates as biosensor electrodes. Here, we report two studies using vertically aligned CNF nanoelectrodes for biomedical applications. CNF arrays are investigated as neural stimulation and neurotransmitter recording electrodes for application in deep brain stimulation (DBS). Polypyrrole coated CNF nanoelectrodes have shown great promise as stimulating electrodes due to their large surface area, low impedance, biocompatibility and capacity for highly localized stimulation. CNFs embedded in SiO2 have been used as sensing electrodes for neurotransmitter detection. Our approach combines a multiplexed CNF electrode chip, developed at NASA Ames Research Center, with the Wireless Instantaneous Neurotransmitter Concentration Sensor (WINCS) system, developed at the Mayo Clinic. Preliminary results indicate that the CNF nanoelectrode arrays are easily integrated with WINCS for neurotransmitter detection in a multiplexed array format. In the future, combining CNF based stimulating and recording electrodes with WINCS may lay the foundation for an implantable smart therapeutic system that utilizes neurochemical feedback control while likely resulting in increased DBS application in various neuropsychiatric disorders. In total, our goal is to take advantage of the nanostructure of CNF arrays for biosensing studies requiring ultrahigh sensitivity, high-degree of miniaturization, and selective biofunctionalization.

  10. Carbon Nanofiber Nanoelectrodes for Neural Stimulation and Chemical Detection: The Era of Smart Deep Brain Stimulation

    NASA Technical Reports Server (NTRS)

    Koehne, Jessica E.

    2016-01-01

    A sensor platform based on vertically aligned carbon nanofibers (CNFs) has been developed. Their inherent nanometer scale, high conductivity, wide potential window, good biocompatibility and well-defined surface chemistry make them ideal candidates as biosensor electrodes. Here, we report two studies using vertically aligned CNF nanoelectrodes for biomedical applications. CNF arrays are investigated as neural stimulation and neurotransmitter recording electrodes for application in deep brain stimulation (DBS). Polypyrrole coated CNF nanoelectrodes have shown great promise as stimulating electrodes due to their large surface area, low impedance, biocompatibility and capacity for highly localized stimulation. CNFs embedded in SiO2 have been used as sensing electrodes for neurotransmitter detection. Our approach combines a multiplexed CNF electrode chip, developed at NASA Ames Research Center, with the Wireless Instantaneous Neurotransmitter Concentration Sensor (WINCS) system, developed at the Mayo Clinic. Preliminary results indicate that the CNF nanoelectrode arrays are easily integrated with WINCS for neurotransmitter detection in a multiplexed array format. In the future, combining CNF based stimulating and recording electrodes with WINCS may lay the foundation for an implantable "smart" therapeutic system that utilizes neurochemical feedback control while likely resulting in increased DBS application in various neuropsychiatric disorders. In total, our goal is to take advantage of the nanostructure of CNF arrays for biosensing studies requiring ultrahigh sensitivity, high-degree of miniaturization, and selective biofunctionalization.

  11. Replication of CLU, CR1, and PICALM associations with alzheimer disease.

    PubMed

    Carrasquillo, Minerva M; Belbin, Olivia; Hunter, Talisha A; Ma, Li; Bisceglio, Gina D; Zou, Fanggeng; Crook, Julia E; Pankratz, V Shane; Dickson, Dennis W; Graff-Radford, Neill R; Petersen, Ronald C; Morgan, Kevin; Younkin, Steven G

    2010-08-01

    To test for replication of the association between variants in the CLU, CR1, and PICALM genes with Alzheimer disease. Follow-up case-control association study. The Mayo Clinics at Jacksonville, Florida, and Rochester, Minnesota. Community-based patients of European descent with late-onset Alzheimer disease (LOAD) and controls without dementia who were seen at the Mayo clinics, and autopsy-confirmed cases and controls whose pathology was evaluated at the Mayo Clinic in Jacksonville. Additional samples were obtained from the National Cell Repository for Alzheimer Disease (NCRAD). A total of 1829 LOAD cases and 2576 controls were analyzed. The most significant single-nucleotide polymorphisms in CLU (rs11136000), CR1 (rs3818361), and PICALM (rs3851179) were tested for allelic association with LOAD. Main Outcome Measure Clinical or pathology-confirmed diagnosis of LOAD. Odds ratios for CLU, CR1, and PICALM were 0.82, 1.15, and 0.80, respectively, comparable in direction and magnitude with those originally reported. P values were 8.6 x 10(-5), .014, and 1.3 x 10(-5), respectively; they remain significant even after Bonferroni correction for the 3 single-nucleotide polymorphisms tested. These results show near-perfect replication and provide the first additional evidence that CLU, CR1, and PICALM are associated with the risk of LOAD.

  12. Cushing Syndrome in Carney Complex: Clinical, Pathologic, and Molecular Genetic Findings in the 17 Affected Mayo Clinic Patients.

    PubMed

    Lowe, Kathleen M; Young, William F; Lyssikatos, Charalampos; Stratakis, Constantine A; Carney, J Aidan

    2017-02-01

    Carney complex (CNC) is a rare dominantly inherited multiorgan tumoral disorder that includes Cushing syndrome (CS). To establish the Mayo Clinic experience with the CS component, including its clinical, laboratory, and pathologic findings, we performed a retrospective search of the patient and pathologic databases of Mayo Clinic in Rochester, MN, for patients with CNC and clinical or laboratory findings of CS. Thirty-seven patients with CNC were identified. Twenty-nine had clinical, pathologic, or laboratory evidence of an adrenocortical disorder. Seventeen had classic CS; 15 underwent bilateral, subtotal, or partial unilateral adrenalectomy, and 2 had no treatment. Pathologically, the glands were normal sized or slightly enlarged with multiple small (1 to 4 mm), brown, black, and yellow micronodules (primary pigmented nodular adrenocortical disease; PPNAD). Three glands each had a mass: a 2 cm adenoma, a 1.5 cm macronodule, and an unencapsulated 1.8 cm myelolipoma. Fourteen of the patients were alive at follow-up, and 3 were deceased; 2 of the latter had PPNAD at autopsy, and the third had PPNAD at surgery. Twelve patients without clinical features of classic CS had abnormal adrenocortical testing results; none developed classic CS during follow-up (mean, 10 y). Autopsy findings in 1 showed bilateral vacuolated cell cortical hyperplasia.

  13. Occupant Interactions and Effectiveness of Natural Ventilation Strategies in Contemporary New Housing in Scotland, UK.

    PubMed

    Sharpe, Tim; Farren, Paul; Howieson, Stirling; Tuohy, Paul; McQuillan, Jonathan

    2015-07-21

    The need to reduce carbon emissions and fuel poverty has led to increased building envelope air tightness, intended to reduce uncontrolled ventilation heat losses. Ventilation strategies in dwellings still allow the use of trickle ventilators in window frames for background ventilation. The extent to which this results in "healthy" Indoor Air Quality (IAQ) in recently constructed dwellings was a concern of regulators in Scotland. This paper describes research to explore this. First a review of literature was conducted, then data on occupant interactions with ventilation provisions (windows, doors, trickle vents) gathered through an interview-based survey of 200 recently constructed dwellings, and measurements made on a sample of 40 of these. The main measured parameter discussed here is CO2 concentration. It was concluded after the literature review that 1000 ppm absolute was a reasonable threshold to use for "adequate" ventilation. The occupant survey found that there was very little occupant interaction with the trickle ventilators e.g., in bedrooms 63% were always closed, 28% always open, and in only 9% of cases occupants intervened to make occasional adjustments. In the measured dwellings average bedroom CO2 levels of 1520 ppm during occupied (night time) hours were observed. Where windows were open the average bedroom CO2 levels were 972 ppm. With windows closed, the combination of "trickle ventilators open plus doors open" gave an average of 1021 ppm. "Trickle ventilators open" gave an average of 1571 ppm. All other combinations gave averages of 1550 to 2000 ppm. Ventilation rates and air change rates were estimated from measured CO2 levels, for all dwellings calculated ventilation rate was less than 8 L/s/p, in 42% of cases calculated air change rate was less than 0.5 ach. It was concluded that trickle ventilation as installed and used is ineffective in meeting desired ventilation rates, evidenced by high CO2 levels reported across the sampled dwellings. Potential implications of the results are discussed.

  14. Direct and Indirect Effects of Tofacitinib on Treatment Satisfaction in Patients with Ulcerative Colitis.

    PubMed

    Panés, Julian; Su, Chinyu; Bushmakin, Andrew G; Cappelleri, Joseph C; Healey, Paul

    2016-11-01

    This mediation modelling analysis evaluated direct and indirect effects of tofacitinib, an oral, small molecule Janus kinase inhibitor under investigation for ulcerative colitis, on patient treatment satisfaction. Data from an 8-week randomized Phase 2 trial [NCT00787202] in adults with moderate-to-severe, active ulcerative colitis receiving twice-daily tofacitinib 0.5-15mg [n=146] or placebo [n=48] were analysed in patient-reported [n=149] and clinician-reported [n=170] outcomes-based mediation models. Binary predictor variable: Treatment [pooled active treatment vs placebo]. Eventual dependent variable: Week 8 patient treatment satisfaction [measured on a five-point Likert scale]. Mediators of treatment effect on satisfaction: Week 8 Inflammatory Bowel Disease Questionnaire domains [Bowel Symptoms, Emotional Health, Social Function and Systemic Symptoms] and Mayo scale domains [Stool Frequency, Rectal Bleeding, Physician's Global Assessment and Endoscopic Disease Activity] for patient-reported and clinician-reported models, respectively. Overall tofacitinib indirect effect on satisfaction via Inflammatory Bowel Disease Questionnaire domains was 40.5% [p<0.05] and via Mayo scale domains was 84.0% [p<0.01] for patient-reported and clinician-reported models, respectively. Bowel function had the most important indirect effect: of the total tofacitinib effect on satisfaction, 32.4% [p=0.05] was indirectly mediated via Bowel Symptoms; and 30.0% [p=0.04] via Stool Frequency. In total, 59.5% [p<0.01] and only 16.0% [p=0.56] of tofacitinib's effect on satisfaction was unrelated to Inflammatory Bowel Disease Questionnaire and Mayo scale domains in the patient-reported and clinician-reported models, respectively. Bowel function is an important factor for patient treatment satisfaction with tofacitinib. Treatment effect on patient satisfaction was almost completely mediated via improvement in Mayo scale domains. Copyright © 2016 European Crohn’s and Colitis Organisation (ECCO). Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oup.com.

  15. Evaluation of consumer drug information databases.

    PubMed

    Choi, J A; Sullivan, J; Pankaskie, M; Brufsky, J

    1999-01-01

    To evaluate prescription drug information contained in six consumer drug information databases available on CD-ROM, and to make health care professionals aware of the information provided, so that they may appropriately recommend these databases for use by their patients. Observational study of six consumer drug information databases: The Corner Drug Store, Home Medical Advisor, Mayo Clinic Family Pharmacist, Medical Drug Reference, Mosby's Medical Encyclopedia, and PharmAssist. Not applicable. Not applicable. Information on 20 frequently prescribed drugs was evaluated in each database. The databases were ranked using a point-scale system based on primary and secondary assessment criteria. For the primary assessment, 20 categories of information based on those included in the 1998 edition of the USP DI Volume II, Advice for the Patient: Drug Information in Lay Language were evaluated for each of the 20 drugs, and each database could earn up to 400 points (for example, 1 point was awarded if the database mentioned a drug's mechanism of action). For the secondary assessment, the inclusion of 8 additional features that could enhance the utility of the databases was evaluated (for example, 1 point was awarded if the database contained a picture of the drug), and each database could earn up to 8 points. The results of the primary and secondary assessments, listed in order of highest to lowest number of points earned, are as follows: Primary assessment--Mayo Clinic Family Pharmacist (379), Medical Drug Reference (251), PharmAssist (176), Home Medical Advisor (113.5), The Corner Drug Store (98), and Mosby's Medical Encyclopedia (18.5); secondary assessment--The Mayo Clinic Family Pharmacist (8), The Corner Drug Store (5), Mosby's Medical Encyclopedia (5), Home Medical Advisor (4), Medical Drug Reference (4), and PharmAssist (3). The Mayo Clinic Family Pharmacist was the most accurate and complete source of prescription drug information based on the USP DI Volume II and would be an appropriate database for health care professionals to recommend to patients.

  16. Fetoscopic Therapy for Severe Pulmonary Hypoplasia in Congenital Diaphragmatic Hernia: A First in Prenatal Regenerative Medicine at Mayo Clinic.

    PubMed

    Ruano, Rodrigo; Klinkner, Denise B; Balakrishnan, Karthik; Novoa Y Novoa, Victoria A; Davies, Norman; Potter, Dean D; Carey, William A; Colby, Christopher E; Kolbe, Amy B; Arendt, Katherine W; Segura, Leal; Sviggum, Hans P; Lemens, Maureen A; Famuyide, Abimbola; Terzic, Andre

    2018-05-15

    To introduce the prenatal regenerative medicine service at Mayo Clinic for fetal endoscopic tracheal occlusion (FETO) care for severe congenital diaphragmatic hernia (CDH). Two cases of prenatal management of severe CDH with FETO between January and August 2017 are reported. Per protocol, FETO was offered for life-threatening severe CDH at between 26 and 29 weeks' gestation. Regenerative outcome end point was fetal lung growth. Gestational age at procedure and maternal and perinatal outcomes were additional monitored parameters. Diagnosis by ultrasonography of severe CDH was based on extremely reduced lung size (observed-to-expected lung area to head circumference ratio [o/e-LHR], eg, o/e-LHR of 20.3% for fetus 1 and 23.0% for fetus 2) along with greater than one-third of the liver herniated into the chest in both fetuses. Both patients underwent successful FETO at 28 weeks. At the time of intervention, no maternal or fetal complications were observed. Postintervention, fetal lung growth was observed in both fetuses, reaching an o/e-LHR of 62.7% at 36 weeks in fetus 1 and 52.4% at 32 weeks in fetus 2. The balloons were removed successfully at 35 weeks and 4 days by ultrasound-guided puncture in the first patient and at 32 weeks and 3 days by ex utero intrapartum therapy-to-airway procedure in the second patient. Postnatal management followed standard of care with patch CDH therapy. At discharge, one patient was breathing normally, whereas the other required minimal nasal cannula oxygen support. The successful launch of the first fetoscopic therapy for CDH at Mayo Clinic reveals its feasibility and safety, with early signs of benefit documented by fetal lung growth and reversal of severe pulmonary hypoplasia. clinicaltrials.gov Identifier: G170062. Copyright © 2018 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc. All rights reserved.

  17. Use of echocardiography in outpatients with chest pain and normal resting electrocardiograms referred to Mayo Clinic Rochester.

    PubMed

    Gibbons, Raymond J; Carryer, Damita; Liu, Hongfang; Brady, Peter A; Askew, John Wells; Hodge, David; Ammash, Naser; Ebbert, Jon O; Roger, Veronique L

    2018-02-01

    To determine how often unnecessary resting echocardiograms that are "not recommended" by clinical practice guidelines are performed in patients with stable chest pain and normal resting electrocardiograms (ECGs). There are scant data to indicate how often Class III recommendations are ignored in clinical practice. We searched electronically all medical records of referral outpatients seen at Mayo Clinic Rochester from January 1, 2010, through December 31, 2013, to identify patients with stable chest pain and known or suspected coronary artery disease who underwent resting echocardiography and had normal resting ECGs and no other indication for echocardiography. Of the 15,529 referral outpatients who were evaluated at Mayo Clinic Rochester with chest pain, 3976 (25.6%) had resting echocardiograms. Eight hundred seventy of these 3976 patients (21.9%) had normal resting ECGs. Six hundred nineteen of these 870 patients (71.1%) had other indications for echocardiography. The remaining 251 patients (6.3% of all echocardiograms and 1.6% of all patients) had normal resting ECGs and no other indication for echocardiography. Two hundred thirty-nine of these 251 patients (95.2%) had normal echocardiograms. Of the 12 abnormal echocardiograms, only 4 led to any change in clinical management. Sixty-one of these 251 echocardiograms (24.3%) were "preordered" before the provider (physicians, nurses, physician assistants) visit. Echocardiograms were performed in 1 in 4 referral outpatients with chest pain seen at Mayo Clinic Rochester. However, only 1 in 16 of these echocardiograms was performed in violation of the class III recommendation in the American College of Cardiology Foundation/American Heart Association guidelines for the management of stable angina. These unnecessary echocardiograms were almost always normal, and had little impact on clinical management. The rate of unnecessary echocardiograms could be decreased by eliminating preordering. Copyright © 2017 Elsevier Inc. All rights reserved.

  18. Design and characterization of a durable and highly efficient energy-harvesting electrochromic window

    NASA Astrophysics Data System (ADS)

    Amasawa, Eri

    With the growing global energy demands, electrochromic window (ECW) technology has attracted great attention for its ability to reversibly change the transmittance of incoming light through applied moderate potential. While ECW has a great potential to conserve energy from lighting and air conditioning in buildings, ECW still consumes energy; ECW should be self-powered for further energy conservation. In this study, a new design of energy-harvesting electrochromic window (EH-ECW) based on fusion of two technologies, organic electrochromic window and dye-sensitized solar cell (DSSC) is presented. Unlike other self-powered smart windows such as photoelectrochromic device that only contains two states (i.e. closed circuit colored state and open circuit bleaching state), EH-ECW allows active tuning of transmittance through varying applied potential and function as a photovoltaic cell based on DSSC. The resulting device demonstrates fast switching rate of 1 second in both bleaching and coloring process through the use of electrochromic polymer as a counter electrode layer. In order to increase the transmittance of the device, cobalt redox couple and light colored yet efficient organic dye are employed. The organic dye utilized contains polymeric structure, which contributes to high cyclic stability. The device exhibits power conversion efficiency (PCE) of 4.5 % under AM 1.5 irradiation (100 mW/cm2), change in transmittance (Delta T = Tmax - Tmin) of 34 % upon applied potential, and shows only 3 % degradation in PCE after 5000 cycles.

  19. Major clinical events, signs and severity assessment scores related to actual survival in patients who died from primary biliary cirrhosis. A long-term historical cohort study.

    PubMed

    van Dam, G M; Gips, C H; Reisman, Y; Maas, K W; Purmer, I M; Huizenga, J R; Verbaan, B W

    1999-01-01

    One of the prognostic methods for survival in primary biliary cirrhosis (PBC) is the Mayo model, with a time-scale limited to 7 years. The aim of our study was to assess how major clinical events, signs, several severity assessment methods and Mayo survival probabilities fit in with actual patient survival, by using yearly observations until 0.5 years before patient death from PBC. Data of 32 patients dying from PBC were collected prior to death at -0.5, -1, -2 etc. years (median: -5 years, range: -16 to -0.5 years). Major events registered were: first occurrence of ascites, upper gastrointestinal bleeding or manifest hepatic encephalopathy and signs, first observation of spider naevi or purpura. Severity assessment methods applied (all with scores and classes) were: Mayo (M), Child-Campbell (C), Pugh-Child (P), Pugh-Child-PBC (PP), 'Child-Pugh' (CP), and Ascites Nutritional State-Child (ANS). Fifty percent survival estimates were calculated from Mayo scores. Severity assessment method variables were: ascites (C, P, PP, CP, ANS), encephalopathy (C, P, PP, CP), nutritional state (C, ANS), edema (M), age (M), serum albumin (M, C, P, PP, CP), bilirubin (C, M, P, PP, CP), and prothrombin time (M, P, PP, CP). In 27 out of 32 patients a major event occurred, always between -6 and -0.5 years (median: -1 year) and, never between -16 and -7 years (p < 0.0001). A sign was first observed in 30/32 between -14 and -0.5 years (median: -2 years). Compared to the total population, a sign, and even more so, an event indicated a shorter survival (p = 0.004 and p = 0.0002, respectively). The median 50% estimated survival (predicted by the Mayo model) fitted the actual survival from -6 to -0.5 years (r = -0.7, p < 0.0001), but not from -16 to -7 years (r = -0.1, p = 0.4). All -6 to -0.5-year severity scores correlated (p < 0.0001) both with actual survival (M, C, P, PP, and CP r = 0.7; ANS r = 0.5) and with estimated M 50% survival (C, P, PP, CP r = -0.9; ANS r = -0.6; M score: -0.99), but none with actual survival from -16 to -7 years, except for M, slightly (r = -0.3, p = 0.04). A nomogram for mean C, CP, M and ANS scores related to actual survival was constructed for the -6 to -0.5-year period. The C and CP classes A, B, and C did not appear to distinguish sufficiently into actual survival, whereas the M classes did. The occurrence of a major event appeared to exclude survival over 6 years. In these final 6 years, Child-Campbell, Mayo and Pugh scores correlated equally well with actual survival and better than Ascites/Nutritional State score. In our PBC patients, Campbell was an excellent alternative for Pugh; for Pugh, the original Child-Turcotte variable limits were fully sufficient.

  20. Towards component-based validation of GATE: aspects of the coincidence processor.

    PubMed

    Moraes, Eder R; Poon, Jonathan K; Balakrishnan, Karthikayan; Wang, Wenli; Badawi, Ramsey D

    2015-02-01

    GATE is public domain software widely used for Monte Carlo simulation in emission tomography. Validations of GATE have primarily been performed on a whole-system basis, leaving the possibility that errors in one sub-system may be offset by errors in others. We assess the accuracy of the GATE PET coincidence generation sub-system in isolation, focusing on the options most closely modeling the majority of commercially available scanners. Independent coincidence generators were coded by teams at Toshiba Medical Research Unit (TMRU) and UC Davis. A model similar to the Siemens mCT scanner was created in GATE. Annihilation photons interacting with the detectors were recorded. Coincidences were generated using GATE, TMRU and UC Davis code and results compared to "ground truth" obtained from the history of the photon interactions. GATE was tested twice, once with every qualified single event opening a time window and initiating a coincidence check (the "multiple window method"), and once where a time window is opened and a coincidence check initiated only by the first single event to occur after the end of the prior time window (the "single window method"). True, scattered and random coincidences were compared. Noise equivalent count rates were also computed and compared. The TMRU and UC Davis coincidence generators agree well with ground truth. With GATE, reasonable accuracy can be obtained if the single window method option is chosen and random coincidences are estimated without use of the delayed coincidence option. However in this GATE version, other parameter combinations can result in significant errors. Copyright © 2014 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd. All rights reserved.

Some links on this page may take you to non-federal websites. Their policies may differ from this site.
Top