Non-commercial surrogacy among close relatives in Vietnam: policy and ethical implications.

PubMed

Hibino, Yuri

2018-04-19

Altruistic surrogacy among close relatives has been legal in Vietnam since the beginning of 2015. Following the revision of the Marriage and Family Law, there have been dozens of cases of surrogacy, and instances of successful pregnancy and childbirth have also been reported. Although surrogacy was completely prohibited in 2003, numerous local brokers offered commercial surrogacy services. Today, surrogacy is permitted under very limited conditions, and commercial surrogacy is prohibited. However, brokers continue to offer illegal commercial surrogacy services, and some even present its incidence may be increasing. In terms of women's roles, Vietnamese society places the highest value on motherhood, and childless couples are stigmatized. Thus, the demand for surrogates is high in Vietnam, rendering it difficult for family members to meet the needs of all those seeking these services. This article considers the consequences and implications of the new surrogacy policy in Vietnam based on field research.

Entrepreneurship.

PubMed

Yetisen, Ali K; Volpatti, Lisa R; Coskun, Ahmet F; Cho, Sangyeon; Kamrani, Ehsan; Butt, Haider; Khademhosseini, Ali; Yun, Seok Hyun

2015-01-01

High-tech businesses are the driving force behind global knowledge-based economies. Academic institutions have positioned themselves to serve the high-tech industry through consulting, licensing, and university spinoffs. The awareness of commercialization strategies and building an entrepreneurial culture can help academics to efficiently transfer their inventions to the market to achieve the maximum value. Here, the concept of high-tech entrepreneurship is discussed from lab to market in technology-intensive sectors such as nanotechnology, photonics, and biotechnology, specifically in the context of lab-on-a-chip devices. This article provides strategies for choosing a commercialization approach, financing a startup, marketing a product, and planning an exit. Common reasons for startup company failures are discussed and guidelines to overcome these challenges are suggested. The discussion is supplemented with case studies of successful and failed companies. Identifying a market need, assembling a motivated management team, managing resources, and obtaining experienced mentors lead to a successful exit.

Eliminating malaria in Malaysia: the role of partnerships between the public and commercial sectors in Sabah.

PubMed

Sanders, Kelly C; Rundi, Christina; Jelip, Jenarun; Rashman, Yusof; Smith Gueye, Cara; Gosling, Roly D

2014-01-21

Countries in the Asia Pacific region have made great progress in the fight against malaria; several are rapidly approaching elimination. However, malaria control programmes operating in elimination settings face substantial challenges, particularly around mobile migrant populations, access to remote areas and the diversity of vectors with varying biting and breeding behaviours. These challenges can be addressed through subnational collaborations with commercial partners, such as mining or plantation companies, that can conduct or support malaria control activities to cover employees. Such partnerships can be a useful tool for accessing high-risk populations and supporting malaria elimination goals. This observational qualitative case study employed semi-structured key informant interviews to describe partnerships between the Malaysian Malaria Control Programme (MCP), and private palm oil, rubber and acacia plantations in the state of Sabah. Semi-structured interview guides were used to examine resource commitments, incentives, challenges, and successes of the collaborations. Interviews with workers from private plantations and the state of Sabah MCP indicated that partnerships with the commercial sector had contributed to decreases in incidence at plantation sites since 1991. Several plantations contribute financial and human resources toward malaria control efforts and all plantations frequently communicate with the MCP to help monitor the malaria situation on-site. Management of partnerships between private corporations and government entities can be challenging, as prioritization of malaria control may change with annual profits or arrival of new management. Partnering with the commercial sector has been an essential operational strategy to support malaria elimination in Sabah. The successes of these partnerships rely on a common understanding that elimination will be a mutually beneficial outcome for employers and the general public. Best practices included consistent communication, developing government-staffed subsector offices for malaria control on-site, engaging commercial plantations to provide financial and human resources for malaria control activities, and the development of new worker screening programmes. The successes and challenges associated with partnerships between the public and commercial sector can serve as an example for other malaria-eliminating countries with large plantation sectors, and may also be applied to other sectors that employ migrant workers or have commercial enterprises in hard to reach areas.

A cross-sectional ecological analysis of international and sub-national health inequalities in commercial geospatial resource availability.

PubMed

Dotse-Gborgbortsi, Winfred; Wardrop, Nicola; Adewole, Ademola; Thomas, Mair L H; Wright, Jim

2018-05-23

Commercial geospatial data resources are frequently used to understand healthcare utilisation. Although there is widespread evidence of a digital divide for other digital resources and infra-structure, it is unclear how commercial geospatial data resources are distributed relative to health need. To examine the distribution of commercial geospatial data resources relative to health needs, we assembled coverage and quality metrics for commercial geocoding, neighbourhood characterisation, and travel time calculation resources for 183 countries. We developed a country-level, composite index of commercial geospatial data quality/availability and examined its distribution relative to age-standardised all-cause and cause specific (for three main causes of death) mortality using two inequality metrics, the slope index of inequality and relative concentration index. In two sub-national case studies, we also examined geocoding success rates versus area deprivation by district in Eastern Region, Ghana and Lagos State, Nigeria. Internationally, commercial geospatial data resources were inversely related to all-cause mortality. This relationship was more pronounced when examining mortality due to communicable diseases. Commercial geospatial data resources for calculating patient travel times were more equitably distributed relative to health need than resources for characterising neighbourhoods or geocoding patient addresses. Countries such as South Africa have comparatively high commercial geospatial data availability despite high mortality, whilst countries such as South Korea have comparatively low data availability and low mortality. Sub-nationally, evidence was mixed as to whether geocoding success was lowest in more deprived districts. To our knowledge, this is the first global analysis of commercial geospatial data resources in relation to health outcomes. In countries such as South Africa where there is high mortality but also comparatively rich commercial geospatial data, these data resources are a potential resource for examining healthcare utilisation that requires further evaluation. In countries such as Sierra Leone where there is high mortality but minimal commercial geospatial data, alternative approaches such as open data use are needed in quantifying patient travel times, geocoding patient addresses, and characterising patients' neighbourhoods.

Impacts of Changing Racial Composition upon Commercial Land Use Succession and Commercial Structure: A Comparative Neighborhood Analysis.

ERIC Educational Resources Information Center

Schmidt, Charles G.; Lee, Yuk

1978-01-01

Three Denver neighborhoods are used in this comparative analysis to investigate the extent to which racial composition, population, or income influence commercial land use succession patterns and total business composition. (EB)

Using unassisted ecosystem development to restore marginal land case study of post mining areas

NASA Astrophysics Data System (ADS)

Frouz, Jan

2017-04-01

When we evaluate efficiency of individual restoration measures we typically compare individual restoration treatments or compare them with initial state or similar ecosystem in surrounding landscape. We argue that sensible way to show added value of restoration measure is to compare them with unassisted ecosystem development. Case study of ecosystem development in Sokolov post mining district (Czech Republic) show that spontaneous succession of ecosystem can be, in many parameters, comparable with various reclamation approaches. In suitable substrates the succession is driven mainly by site topography. In sites which were leveled grassy vegetation develops. In sites where original wave like topography was preserved the ecosystem develops towards forest. In forest sites the development on most of the investigated ecosystem parameters (cower, biomass soil developments, water holding capacity, carbon storage) in succession sites is little bit slower compare to reclaimed plantation during first 15-20 years. However in older sites differences disappear and succession sites show similarity with restored sites. Despite similarity in these ecosystem functions possibilities of spontaneous sites for commercial use has to be explored.

Commercial considerations in tissue engineering

PubMed Central

Mansbridge, Jonathan

2006-01-01

Tissue engineering is a field with immense promise. Using the example of an early tissue-engineered skin implant, Dermagraft, factors involved in the successful commercial development of devices of this type are explored. Tissue engineering has to strike a balance between tissue culture, which is a resource-intensive activity, and business considerations that are concerned with minimizing cost and maximizing customer convenience. Bioreactor design takes place in a highly regulated environment, so factors to be incorporated into the concept include not only tissue culture considerations but also matters related to asepsis, scaleup, automation and ease of use by the final customer. Dermagraft is an allogeneic tissue. Stasis preservation, in this case cryopreservation, is essential in allogeneic tissue engineering, allowing sterility testing, inventory control and, in the case of Dermagraft, a cellular stress that may be important for hormesis following implantation. Although the use of allogeneic cells provides advantages in manufacturing under suitable conditions, it raises the spectre of immunological rejection. Such rejection has not been experienced with Dermagraft. Possible reasons for this and the vision of further application of allogeneic tissues are important considerations in future tissue-engineered cellular devices. This review illustrates approaches that indicate some of the criteria that may provide a basis for further developments. Marketing is a further requirement for success, which entails understanding of the mechanism of action of the procedure, and is illustrated for Dermagraft. The success of a tissue-engineered product is dependent on many interacting operations, some discussed here, each of which must be performed simultaneously and well. PMID:17005024

Commercial considerations in tissue engineering.

PubMed

Mansbridge, Jonathan

2006-10-01

Tissue engineering is a field with immense promise. Using the example of an early tissue-engineered skin implant, Dermagraft, factors involved in the successful commercial development of devices of this type are explored. Tissue engineering has to strike a balance between tissue culture, which is a resource-intensive activity, and business considerations that are concerned with minimizing cost and maximizing customer convenience. Bioreactor design takes place in a highly regulated environment, so factors to be incorporated into the concept include not only tissue culture considerations but also matters related to asepsis, scaleup, automation and ease of use by the final customer. Dermagraft is an allogeneic tissue. Stasis preservation, in this case cryopreservation, is essential in allogeneic tissue engineering, allowing sterility testing, inventory control and, in the case of Dermagraft, a cellular stress that may be important for hormesis following implantation. Although the use of allogeneic cells provides advantages in manufacturing under suitable conditions, it raises the spectre of immunological rejection. Such rejection has not been experienced with Dermagraft. Possible reasons for this and the vision of further application of allogeneic tissues are important considerations in future tissue-engineered cellular devices. This review illustrates approaches that indicate some of the criteria that may provide a basis for further developments. Marketing is a further requirement for success, which entails understanding of the mechanism of action of the procedure, and is illustrated for Dermagraft. The success of a tissue-engineered product is dependent on many interacting operations, some discussed here, each of which must be performed simultaneously and well.

Implementation of the 2011 Therapeutic Activity Act: will commercialization improve the financial performance of Polish hospitals?

PubMed

Sagan, Anna; Sobczak, Alicja

2014-11-01

The Therapeutic Activity Act that came into force on 1 July 2011 was aimed at achieving a large-scale transformation of public hospitals into Commercial Code companies. The change of the legal form, from a public entity to a for-profit company, was expected to improve the poor economic efficiency of the public hospital sector. However, the mere change of the legal form does not guarantee a better financial performance of hospitals and thus the success of the Act. In many cases, deep internal changes are needed to achieve improvements in the financial performance of particular hospitals. In addition, a set of other measures at the national and regional levels, such as the mapping of health needs of the population, have to accompany the legal transformations in order to improve the efficiency of the hospital sector. The recent slowdown in the rate of the transformations is another factor that renders the success of the Act uncertain. Copyright © 2014. Published by Elsevier Ireland Ltd.

Successful management of ivermectin-induced blindness in an African lion (Panthera leo) by intravenous administration of a lipid emulsion.

PubMed

Saqib, Muhammad; Abbas, Ghazanfar; Mughal, Mudassar Niaz

2015-11-26

Ivermectin is widely used in veterinary practice for the treatment of ecto- and endo-parasites. In wildlife, an extra-label use this parasiticide is sometimes associated with toxicity. Different treatment regimens have been used in ivermectin toxicosis. The present report describes a successful reversal of ivermectin toxicity by intravenous administration of a commercially available lipid emulsion in a captive African lion (Panthera leo). A 2-year old captive African lion (Panthera leo) weighing ~130 kg was presented with acute neurological impairment and bilateral blindness that had developed 24 h after ivermectin exposure. The animal was treated with a commercially available lipid emulsion along with supportive therapy and experienced complete recovery. To our knowledge, this is the first case report of the use of lipid emulsion in the management of ivermectin induced blindness in an African lion and it appears that intravenous lipid emulsion may be an effective therapy in ivermectin toxicity in lions. Further testing in expanded clinical trials is clearly warranted.

On-site customization of silicone stents: towards optimal palliation of complex airway conditions.

PubMed

Breen, David P; Dutau, Hervé

2009-01-01

Stents may be indicated as treatment of benign and malignant conditions of the central airways. Occasionally, aberrant and/or distorted airways secondary to therapy or surgery may preclude the use of commercially manufactured stents. The customization of stents is well described for nonpulmonary diseases, but to date there are only limited data in the literature on prosthesis customization for airway disease. To review all the different techniques and indications of on-site silicone stent customizations and their related complications. A retrospective study was undertaken to identify all patients who underwent treatment with a silicone stent which was customized on site by the physician. The study included subjects treated during an 8-year period. Forty-nine on-site customizations were performed in 43 patients (34 males, mean age 63 +/- 5.2 years). Stent customization was performed in 5.4% of the cases. Stent customization was performed for malignant and benign disease in 35 (81.3%) and 8 (18.7%) cases, respectively. In all cases, the stent deployed successfully and performed well while in situ. Stent manipulation did not increase complications. Customization of airway stents by the physician can lead to successful stenting of difficult airway lesions with a good short-term safety profile. Standard commercially available stents may have resulted in suboptimal management of complex airway pathologies. A prospective study is warranted to further investigate the safety profile and complications associated with stent customization. Copyright 2009 S. Karger AG, Basel.

ELOPTA: a novel microcontroller-based operant device.

PubMed

Hoffman, Adam M; Song, Jianjian; Tuttle, Elaina M

2007-11-01

Operant devices have been used for many years in animal behavior research, yet such devices a regenerally highly specialized and quite expensive. Although commercial models are somewhat adaptable and resilient, they are also extremely expensive and are controlled by difficult to learn proprietary software. As an alternative to commercial devices, we have designed and produced a fully functional, programmable operant device, using a PICmicro microcontroller (Microchip Technology, Inc.). The electronic operant testing apparatus (ELOPTA) is designed to deliver food when a study animal, in this case a bird, successfully depresses the correct sequence of illuminated keys. The device logs each keypress and can detect and log whenever a test animal i spositioned at the device. Data can be easily transferred to a computer and imported into any statistical analysis software. At about 3% the cost of a commercial device, ELOPTA will advance behavioral sciences, including behavioral ecology, animal learning and cognition, and ethology.

Development of mobile laboratory for viral haemorrhagic fever detection in Africa.

PubMed

Weidmann, Manfred; Faye, Ousmane; Faye, Oumar; Abd El Wahed, Ahmed; Patel, Pranav; Batejat, Christophe; Manugerra, Jean Claude; Adjami, Aimee; Niedrig, Matthias; Hufert, Frank T; Sall, Amadou A

2018-06-15

In order to enable local response to viral haemorrhagic fever outbreaks a mobile laboratory transportable on commercial flights was developed. The development progressed from use of mobile real time RT-PCR to mobile Recombinase Polymerase Amplification (RT-RPA). The various stages of the mobile laboratory development are described. A brief overview of its deployments, which culminated in the first on site detection of Ebola virus disease (EVD) in March 2014 and a successful use in a campaign to roll back EVD cases in Conakry in the West-Africa Ebola virus outbreak are described. The developed mobile laboratory successfully enabled local teams to perform rapid viral haemorrhagic fever disgnostics.

Energy, mining, and the commercial success of the Newcomen "steam" engine

NASA Astrophysics Data System (ADS)

Murphy, John Paul

This dissertation is about energy; specifically how prime movers changed at the beginning of the Industrial Revolution. These power needs are explored via the history of the Newcomen atmospheric engine, as it was used in the 18th century to drive pumps in flooded mines. This approach examines society as an energy-converting phenomenon, and uses the concept of an energy rent. The dissertation seeks to reach past the 19th century's "high-pressure historiography" of the first engines powered by fire; instead, it traces the actual low-pressure atmospheric technology of the first commercially successful engines, and the surprising, rather than inevitable, transformation they engendered. The costs of fuel are shown to be an essential factor in the success or failure of the first Newcomen engines. Thomas Newcomen's failed first attempts in Cornwall (1710) are contrasted with success in collieries, located in the relatively distant region of the Midlands, only two years later. To test the suggestion that coal is needed for a Newcomen engine to be profitable, two detailed case histories compare 18th century engines, both fired using wood fuel, at iron ore mines. The first was a failed engine at Dannemora, Sweden (1728); the second a successful machine built by the Brown brothers at Cranston, Rhode Island (1783). The Brown engine's case history was based on extensive original archive research, and also provides a detailed history of the Hope Furnace, which used the ore from Cranston. Success for the Browns in Rhode Island is found to have been rooted in their careful planning for fuel needs. The two mines were also found to have significantly different construction of gender roles, suggesting the Rhode Island context had established more thoroughly capitalist relations. The work shows that the demand for more extensive power, which led to these engines, was propelled by the ability of the evolving commercial market place to convert energy profitably (16th and 17th centuries in Europe). The resulting pressure to expand society's energy envelope created this "need" for primary power, which was particularly acute at mining enterprises. A vocabulary for cross-comparing primary movers is developed. The Newcomen engine is found to have teetered on the border between negative and positive energy rents. The dissertation concludes that it tipped positive, when applied in an energy intensive environment, thus contributed to a divergence from the equilibrium of an advanced agricultural society.

Successes of Small Business Innovation Research at NASA Glenn Research Center

NASA Technical Reports Server (NTRS)

Kim, Walter S.; Bitler, Dean W.; Prok, George M.; Metzger, Marie E.; Dreibelbis, Cindy L.; Ganss, Meghan

2002-01-01

This booklet of success stories highlights the NASA Glenn Research Center's accomplishments and successes by the Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) Programs. These success stories are the results of selecting projects that support NASA missions and also have high commercialization potential. Each success story describes the innovation accomplished, commercialization of the technology, and further applications and usages. This booklet emphasizes the integration and incorporation of technologies into NASA missions and other government projects. The company name and the NASA contact person are identified to encourage further usage and application of the SBIR developed technologies and also to promote further commercialization of these products.

Eliminating malaria in Malaysia: the role of partnerships between the public and commercial sectors in Sabah

PubMed Central

2014-01-01

Background Countries in the Asia Pacific region have made great progress in the fight against malaria; several are rapidly approaching elimination. However, malaria control programmes operating in elimination settings face substantial challenges, particularly around mobile migrant populations, access to remote areas and the diversity of vectors with varying biting and breeding behaviours. These challenges can be addressed through subnational collaborations with commercial partners, such as mining or plantation companies, that can conduct or support malaria control activities to cover employees. Such partnerships can be a useful tool for accessing high-risk populations and supporting malaria elimination goals. Methods This observational qualitative case study employed semi-structured key informant interviews to describe partnerships between the Malaysian Malaria Control Programme (MCP), and private palm oil, rubber and acacia plantations in the state of Sabah. Semi-structured interview guides were used to examine resource commitments, incentives, challenges, and successes of the collaborations. Results Interviews with workers from private plantations and the state of Sabah MCP indicated that partnerships with the commercial sector had contributed to decreases in incidence at plantation sites since 1991. Several plantations contribute financial and human resources toward malaria control efforts and all plantations frequently communicate with the MCP to help monitor the malaria situation on-site. Management of partnerships between private corporations and government entities can be challenging, as prioritization of malaria control may change with annual profits or arrival of new management. Conclusions Partnering with the commercial sector has been an essential operational strategy to support malaria elimination in Sabah. The successes of these partnerships rely on a common understanding that elimination will be a mutually beneficial outcome for employers and the general public. Best practices included consistent communication, developing government-staffed subsector offices for malaria control on-site, engaging commercial plantations to provide financial and human resources for malaria control activities, and the development of new worker screening programmes. The successes and challenges associated with partnerships between the public and commercial sector can serve as an example for other malaria-eliminating countries with large plantation sectors, and may also be applied to other sectors that employ migrant workers or have commercial enterprises in hard to reach areas. PMID:24443824

Influences Determining European Coal Seam Gas Deliverability

NASA Astrophysics Data System (ADS)

Clark, G.

2009-04-01

Technically the coal basins of Europe have generated significant Gas In Place figures that has historically generated investor's interest in the development of this potential coal seam gas (CSG) resource. In the early 1980's, a wave of international, principally American, companies arrived, established themselves, drilled and then left with a poor record of success and disappointed investors. Recently a second wave of investment started after 2002, with the smaller companies leading the charge but have the lesson been learned from the past failures? To select a CSG investment project the common European approach has been to: 1. Find an old mining region; 2. Look to see if it had a coal mine methane gas problem; 3. Look for the non-mined coal seams; and 4. Peg the land. This method is perhaps the reason why the history of CSG exploration in Europe is such a disappointment as generally the coal mining regions of Europe do not have commercial CSG reservoir attributes. As a result, investors and governments have lost confidence that CSG will be a commercial success in Europe. New European specific principles for the determination of commercial CSG prospects have had to be delineated that allow for the selection of coal basins that have a strong technical case for deliverability. This will result in the return of investor confidence.

Using Monte Carlo Simulation To Improve Cargo Mass Estimates For International Space Station Commercial Resupply Flights

DTIC Science & Technology

2016-12-01

laboratory. The transition of this function to the commercial sector under Firm Fixed-Price contracting has forced both NASA and commercial providers to...adjust to make this effort successful. Improving bag-level cargo launch manifests delivered from NASA to the provider more than a year in advance is...contracting has forced both NASA and commercial providers to adjust to make this effort successful. Improving bag-level cargo launch manifests delivered from

Commercial integration and partnering at Savannah River Site

DOE Office of Scientific and Technical Information (OSTI.GOV)

Steele, J.R.; Babione, R.A.; Shikashio, L.A.

1994-06-01

Savannah River Site (SRS), particularly the Savannah River Technology Center (SRTC) with the experience from the first successful Integrated Technology Demonstration, can provide an excellent foundation for meeting DOE-EM`s objectives with the new DOE-EM five focus area approach. With this in mind, SRTC established an activity to pursue full commercialization of environmental technologies. This report is an assessment of the status of commercialization at SRS and provides recommendations for enhancement as well as some tools critical to implementation. A review was made of the current situation at SRS with regards to taking technology development to commercial fruition. This was donemore » from the perspective of comparing it to known commercialization models and processes. It was found that SRTC already works through many of the steps in these processes. With integration and action-oriented efforts of the inclusion of business and market factors, SRTC could become an aggressive, successful developer of commercialized technologies. Commercial success criteria tools were developed with regards to integrating them with SRTC selection criteria to ensure that all critical factors are covered in technology commercialization project evaluations. Private investors are very clear that their interest lies in funding commercial enterprises, not merely technologies. Mobilizing private capital is critical to real job growth and long-term economic development. Also, potential industry partners were identified that are willing to be involved with SRS` technology applications and regional development efforts. As another important component to success, regional support organizations were reviewed and evaluated.« less

A multi-institutional survey of interventional radiology for type II endoleaks after endovascular aortic repair: questionnaire results from the Japanese Society of Endoluminal Metallic Stents and Grafts in Japan.

PubMed

Ogawa, Yukihisa; Nishimaki, Hiroshi; Osuga, Keigo; Ikeda, Osamu; Hongo, Norio; Iwakoshi, Shinichi; Kawasaki, Ryota; Woodhams, Reiko; Yamaguchi, Masato; Kamiya, Mika; Kanematsu, Masayuki; Honda, Masanori; Kaminou, Toshio; Koizumi, Jun; Kichikawa, Kimihiko

2016-08-01

To investigate the current status of interventional radiology (IR) procedures for a type II endoleak (T2EL) in Japan, and to identify the technical aspects that affect treatment results. A retrospective survey was conducted by distributing questionnaires to 25 institutions. The eligibility criteria were endovascular aortic repair (EVAR) performed using commercial stent grafts and IR performed for T2EL between January 2007 and December 2013. Technical success was defined as disappearance of the EL on digital subtraction angiography immediately after embolization, and imaging success was defined as no EL on contrast-enhanced computed tomography within 6 months. Statistical comparisons of the number of involved branches, embolization level, embolic material, and changes in aneurysm size were made between the imaging success and imaging failure groups. The technical and imaging success rates were also compared between the initial therapy and repeat groups. A total of 166 cases were investigated. Initial therapy was performed in 147 cases (88.6 %), with repeat therapy in 19 cases (11.4 %). Transcatheter arterial embolization (TAE) was used most frequently, in 161 cases (97 %), with direct puncture (DP) used in 5 cases (3 %). Both coil embolization for the branches and NBCA embolization for the sac were frequently chosen. The technical success rate was 83.2 % (TAE group), and the imaging success rate was 46.5 % (TAE + DP groups). Branch + sac embolization was performed more frequently in the imaging success group. There was no significant difference in the number of involved branches or embolic material between the imaging success and imaging failure groups. Enlargement of the aneurysm was more frequently seen in the imaging failure group. There were no significant differences in the technical success and imaging success rates between the initial therapy and repeat groups. This is the first report of a multi-institutional questionnaire survey of IR procedures for T2EL after EVAR in Japan that was conducted to determine the current status. Enlargement of aneurysm size after embolization was more frequently seen in the imaging failure group. It is important to embolize both branch and sac to achieve imaging success, regardless of embolic material. Long-term outcomes need to be investigated.

Progress in terpene synthesis strategies through engineering of Saccharomyces cerevisiae.

PubMed

Paramasivan, Kalaivani; Mutturi, Sarma

2017-12-01

Terpenes are natural products with a remarkable diversity in their chemical structures and they hold a significant market share commercially owing to their distinct applications. These potential molecules are usually derived from terrestrial plants, marine and microbial sources. In vitro production of terpenes using plant tissue culture and plant metabolic engineering, although receiving some success, the complexity in downstream processing because of the interference of phenolics and product commercialization due to regulations that are significant concerns. Industrial workhorses' viz., Escherichia coli and Saccharomyces cerevisiae have become microorganisms to produce non-native terpenes in order to address critical issues such as demand-supply imbalance, sustainability and commercial viability. S. cerevisiae enjoys several advantages for synthesizing non-native terpenes with the most significant being the compatibility for expressing cytochrome P450 enzymes from plant origin. Moreover, achievement of high titers such as 40 g/l of amorphadiene, a sesquiterpene, boosts commercial interest and encourages the researchers to envisage both molecular and process strategies for developing yeast cell factories to produce these compounds. This review contains a brief consideration of existing strategies to engineer S. cerevisiae toward the synthesis of terpene molecules. Some of the common targets for synthesis of terpenes in S. cerevisiae are as follows: overexpression of tHMG1, ERG20, upc2-1 in case of all classes of terpenes; repression of ERG9 by replacement of the native promoter with a repressive methionine promoter in case of mono-, di- and sesquiterpenes; overexpression of BTS1 in case of di- and tetraterpenes. Site-directed mutagenesis such as Upc2p (G888A) in case of all classes of terpenes, ERG20p (K197G) in case of monoterpenes, HMG2p (K6R) in case of mono-, di- and sesquiterpenes could be some generic targets. Efforts are made to consolidate various studies (including patents) on this subject to understand the similarities, to identify novel strategies and to contemplate potential possibilities to build a robust yeast cell factory for terpene or terpenoid production. Emphasis is not restricted to metabolic engineering strategies pertaining to sterol and mevalonate pathway, but also other holistic approaches for elsewhere exploitation in the S. cerevisiae genome are discussed. This review also focuses on process considerations and challenges during the mass production of these potential compounds from the engineered strain for commercial exploitation.

A case study in the politics of free-market health care.

PubMed

Begun, J W; Lippincott, R C

1982-01-01

Historically, most health occupations have developed legal and ethical restrictions on price advertising and other characteristics of "commercial" practice. Many of these regulations recently have come under critical scrutiny, on the grounds that they inhibit free-market health care delivery, thus keeping prices high, and productivity and innovation low. To help inform current health policy deliberations, we analyze the political history of anticompetitive regulations in one health occupation, optometry. Restrictions on commercial practice arose as a result of professional optometry's purge of commercial elements in the 1930s. Optometry's success in achieving commercial-practice restrictions at the state level was determined by the economic structure of the ophthalmic goods and services industry in each state in the 1930s, and by the political resources and organization of the competing interest groups. Efforts to deregulate health occupations will precipate political conflict to the extent that economic interests are threatened. Opposition to deregulation will be based overtly on the grounds that quality of care will deteriorate, and a significant political investment by proponents of free-market health care will be required to overcome such opposition.

SBIR Success Stories at NASA Glenn Research Center

NASA Technical Reports Server (NTRS)

Kim, Walter S.; Bitler, Dean W.; Prok, George M.; Metzger, Marie E.; Dreibelbis, Cindy L.; Howe, Meghan R.; Novak, George D.

1999-01-01

This booklet of success stories summarizes the NASA Glenn Research Center's accomplishments and successes by the Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs. These success stories are the results of selecting projects that best support NASA missions and also have commercialization potential. Each success story describes the innovation accomplished, commercialization of the technology, and further applications and usages. The company name and the NASA contact person are identified to encourage further interest and communication to occur.

Issues in Designing Tutors for Games of Incomplete Information: a Bridge Case Study

NASA Astrophysics Data System (ADS)

Kemp, Ray; McKenzie, Ben; Kemp, Elizabeth

There are a number of commercial packages for playing the game of bridge, and even more papers on possible techniques for improving the quality of such systems. We examine some of the AI techniques that have proved successful for implementing bridge playing systems and discuss how they might be adapted for teaching the game. We pay particular attention to the issue of incomplete information and include some of our own research into the subject.

Preliminary Report on Floodplain Animals of the Upper Mississippi River and the Illinois Waterway Including Some Probable Impacts of Increased Commercial Traffic,

DTIC Science & Technology

1975-01-01

case of the canvasback, it is conceivable that a large oil spill in a concentration area during the peak migration period could destroy a substantial...winter crowned Lichtenstein secondary resident kinglet succession 123. Ruby-crowned Regulus calendula Statewide Statewide younger stand, C winter...Regulus calendula . Ruby-crowned Kinglet TV-c Family MOTACLLLIDAS - pipits Anthus spinoletta ’Water Pipit, TV-r Family BOHIYCILLIDAE - waxwings

Market Assessment of Forward-Looking Turbulence Sensing Systems

NASA Technical Reports Server (NTRS)

Kauffmann, Paul

2003-01-01

This viewgraph presentation provides a cost benefit analysis of three next-generation forward-looking turbulence sensing systems: X band turbulence radar system for convective turbulence, LIDAR based turbulence systems to sense clear air turbulence and a combined hybrid system. Parameters for the cost benefit analysis were established using a business model which considered injury rates, cost of injuries, indirect costs, market penetration rate estimates and product success characteristics. Topics covered include: study approach, business case equations, data acquisition, benchmark analysis. Data interpretation from the cost benefit analysis is presented. The researchers conclude that the market potential for these products is based primarily on injury cost reduction and that X band radar systems have the greatest chance for commercial success.

Philippine Islands: a tectonic railroad siding

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gallagher, J.J. Jr.

1984-09-01

In 1976, significant quantities of oil were discovered offshore northwest of Palawan Island by a Philippine-American consortium led by Philippines-Cities Service Inc. This was the first commercial oil found in the Philippine Islands. Other exploration companies had decided that there was no commercial oil in the Philippines. They fell prey to a situation Wallace E. Pratt, who began his career in 1909 in the Philippines, later described: There are many instances where our knowledge, supported in some cases by elaborate and detailed studies has convinced us that no petroleum resources were present in areas which subsequently became sites of importantmore » oil fields. Some explorers are blinded by the negative implications of the same knowledge that successful explorers use to find important oil fields. The Palawan discoveries are examples of successful use of knowledge. Recognition that the Philippine Islands are a tectonic railroad siding may be the key to future exploration success. These islands are continental fragments, each with its own individual geologic characteristics, that have moved from elsewhere to their present positions along a major strike-slip zone. Play concepts can be developed in the Philippines for continental fragments in each of the three major present-day tectono-stratigraphic systems that are dominated by strike-slip, but include subduction and extension tectonics, with both carbonate and clastic sediments.« less

Chapter 15: Discussion on Prior Commercial Wood Preservation Systems That Performed Less Well Than Expected

Treesearch

Tor P. Schultz; Darrel D. Nicholas; Patti Lebow

2014-01-01

This article reviews five prior commercial wood preservatives that had efficacy concerns. A common factor among all five systems was minimal or no field testing of the proposed system prior to commercialization. Also, the formulation of a successful preservative was twice changed, and one successful system was employed with a new wood species. There is no intent to...

Fuel Cell Electric Vehicles: Paving the Way to Commercial Success -

Science.gov Websites

emissions. Photo by Dennis Schroeder, NREL Fuel Cell Electric Vehicles: Paving the Way to Commercial Success advanced vehicle ride-and-drive event at the NREL Education Center. Photo by Dennis Schroeder, NREL "

The Academic Success of East Asian American Youth: The Role of Shadow Education

PubMed Central

Byun, Soo-yong; Park, Hyunjoon

2013-01-01

Using data from the Education Longitudinal Study, this study assessed the relevance of shadow education to the high academic performance of East Asian American students by examining how East Asian American students differed from other racial/ethnic students in the prevalence, purpose, and effects of using the two forms – commercial test preparation service and private one-to-one tutoring – of SAT coaching, defined as the American style of shadow education. East Asian American students were most likely to take a commercial SAT test preparation course for the enrichment purpose, and benefited most from taking this particular form of SAT coaching. However, this was not the case for private SAT one-to-one tutoring. While black students were most likely to utilize private tutoring for the remedial purpose, the impact of private tutoring was trivial for all racial/ethnic groups including East Asian American students. The authors discussed broader implications of the findings on racial/ethnic inequalities in educational achievement beyond the relevance of shadow education for the academic success of East Asian American students. PMID:24163483

Aerospace Technology Innovation. Volume 9

NASA Technical Reports Server (NTRS)

Turner, Janelle (Editor); Cousins, Liz (Editor)

2001-01-01

Commercializing technology is a daunting task. Of every 11 new product ideas, only one will successfully make it to the marketplace. Fully 46% of new product investment becomes sunk in cost. Yet, a few good companies consistently attain an 80% technology commercialization success rate and have lead the way in establishing best practices. The NASA Incubator program consists of nine incubators, each residing near a NASA research center. The purpose of the incubators is to use the best practices is to use the best practices of technology commercialization to help early stage businesses successfully launch new products that incorporate NASA technology.

This is Commercial Titan Inc.

NASA Astrophysics Data System (ADS)

Van Rensselaer, F. L.; Slovikoski, R. D.; Abels, T. C.

Out of a quarter-century heritage of eminently successful expendable launch vehicle history with the U.S. government, a commercial launch services enterprise which challenges the corporation as well as the competition has been launched within the Martin Marietta Corporation. This paper is an inside look at the philosophy, structure, and success of the new subsidiary, Commercial Titan Inc., which is taking on its U.S. and foreign rocket-making competitors to win a share of the international communication satellite market as well as the U.S. government commercial launch services market.

This is Commercial Titan, Inc

NASA Astrophysics Data System (ADS)

van Rensselaer, F. L.; Slovikoski, R. D.; Abels, T. C.

1989-10-01

Out of a quarter-century heritage of eminently successful expendable launch vehicle history with the U.S government, a commercial launch services enterprise which challenges the corporation as well as the competition has been launched within the Martin Marietta Corporation. This paper is an inside look at the philosophy, structure, and success of the new subsidiary, Commercial Titan, Inc., which is taking on its U.S. and foreign rocket-making competitors to win a share of the international communication satellite market as well as the U.S. government commercial launch services market.

Strategies to control a common carp population by pulsed commercial harvest

USGS Publications Warehouse

Colvin, Michael E.; Pierce, Clay; Stewart, Timothy W.; Grummer, Scott E.

2012-01-01

Commercial fisheries are commonly used to manage nuisance fishes in freshwater systems, but such efforts are often unsuccessful. Strategies for successfully controlling a nuisance population of common carp Cyprinus carpio by pulsed commercial harvest were evaluated with a combination of (1) field sampling, (2) population estimation and CPUE indexing, and (3) simulation using an exponential semidiscrete biomass dynamics model (SDBDM). The range of annual fishing mortalities (F) that resulted in successful control (F = 0.244–0.265) was narrow. Common carp biomass dynamics were sensitive to unintentional underharvest due to high rates of surplus production and a biomass doubling time of 2.7 years. Simulations indicated that biomanipulation never achieved successful control unless supplemental fishing mortality was imposed. Harvest of a majority of annual production was required to achieve successful control, as indicated by the ecotrophic coefficient (EC). Readily available biomass data and tools such as SDBDMs and ECs can be used in an adaptive management framework to successfully control common carp and other nuisance fishes by pulsed commercial fishing.

Commercial and home-made nitrogen modified titanias. A short reflection about the advantageous/disadvantageous properties of nitrogen doping in the frame of their applicability

NASA Astrophysics Data System (ADS)

Pap, Zs.; Mogyorósi, K.; Veréb, G.; Dombi, A.; Hernádi, K.; Danciu, V.; Baia, L.

2014-09-01

As visible light driven photocatalysis became more and more intensively studied, the first commercial products showed up on the market. Simultaneously controversial results appeared in the literature generating an intensive debate regarding the advantages and draw-backs of nitrogen doping of titania. Hence, the present work focuses on two commercially available and four sol-gel made nitrogen modified titania powders regarding their structure and activity. It is demonstrated that the interstitial nitrogen entities “leak out” from the catalysts if the material is irradiated with UV light, while substitutional nitrogen remains stable. However, the latter one was proven to be less important in the photocatalytic point of view. These observations were also valid in the case of sol-gel made nitrogen modified titanias. Furthermore, the results obtained after applying different spectroscopic methods (IR, XPS and DRS) shown that the yellow color of the titanias, does not necessary mean that a successful doping is achieved.

Commercialization of Plasma-Assisted Technologies: The Indian Experience

NASA Astrophysics Data System (ADS)

John, P. I.

The paper describes an initiative by the Institute for Plasma Research (IPR), India in establishing links with the Indian industry for developing and commercialising advanced plasma-based industrial technologies. This has culminated in the creation of a self-financing technology development, incubation, demonstration and delivery facility. A business plan for converting the knowledge base to commercially viable technologies conceived technology as a product and the industry as the market and addressed issues like resistance to new technologies, the key role of entrepreneur, thrust areas and the necessity of technology incubation and delivery. Success of this strategy is discussed in a few case studies. We conclude by identifying the cost, environmental, strategic and techno-economic aspects, which would be the prime drivers for plasma-assisted manufacturing technology in India.

Extemporaneous clobazam suspensions for paediatric use prepared from commercially available tablets and pure drug.

PubMed

Buontempo, F; Moretton, M A; Quiroga, E; Chiappetta, D A

2013-01-01

Two clobazam aqueous suspensions for paediatric oral usage (5 mg/ml) were investigated to determinate its physicochemical stability under different storage conditions. Formulations were stored at 4 and 25 °C and the clobazam content was determined by High Performance Liquid Chromatography. Each sample was analyzed by triplicate at different time points (0, 7, 14, 28 and 56 days). Liquid suspensions were successfully formulated from pure drug and commercially available tablets. In both cases, samples showed suitable physical stability. Clobazam was chemically stable in aqueous suspension during the 56 days of the study at the two storage temperatures. All the tried oral liquid formulations can be conserved at 4 and 25 °C at least 56-day period. Copyright © 2013 SEFH. Published by AULA MEDICA. All rights reserved.

Cadaveric Tissue Supply to the Commercial Sector For Research: Collaboration between NHS Pathology and NBS Tissue Services in the U.K., Extending the Options for Donors.

PubMed

Womack, C; Gray, N M; Pearson, J E; Fehily, D

2001-01-01

The Peterborough Hospital Human Tissue Bank (PHHTB) and National Blood Service Tissue Services (London and South East Zone) (NBSTS) operate within the U.K. National Health Service (NHS) and have a system in place to retrieve cadaveric tissues for commercial sector research. The collaboration meets the aims of PHHTB and NBSTS and is legal, ethical and safe. This paper presents the results of the first 20 successful retrievals referred from NBSTS to PHHTB. Cadaveric retrieval of tissue for research extends the options for donors and their relatives. The research option is particularly welcomed in cases where clinical retrieval for tissue transplantation is contraindicated. We believe the system is applicable to other centres.

Pre-colonial culture, post-colonial economic success? The Tswana and the African economic miracle.

PubMed

Hjort, Jonas

2010-01-01

Cultural explanations of economic phenomena have recently enjoyed a renaissance among economists. This article provides further evidence for the salience of culture through an in-depth case study of one of the fastest-growing economies in the world during the last 50 years-Botswana. The unique culture that developed among the Tswana before and during the early days of colonialism, which shared many features with those of western nation-states, appears to have contributed significantly to the factors widely seen as determinants of Botswana's post-colonial economic success: state legitimacy, good governance and democracy, commercial traditions, well-established property rights, and inter-ethnic unity. Neighbouring Southern African cultures typically did not exhibit these traits.

Commercial Titan program - Status and outlook

NASA Astrophysics Data System (ADS)

van Rensselaer, F. L.; Browne, E. M.

Out of a quarter-century heritage of eminently successful expendable launch vehicle history with the U.S. government, a commercial launch services enterprise which challenges the corporation as well as the competition has been launched within the Martin Marietta Corporation. This paper is an inside look at the philosophy, structure, and success of the new subsidiary, which is attempting to win a share of the international communication satellite market as well as the U.S. government commercial launch services market.

Behavioural factors related with successful weight loss 15 months post-enrolment in a commercial web-based weight-loss programme.

PubMed

Neve, Melinda J; Morgan, Philip J; Collins, Clare E

2012-07-01

As further understanding is required of what behavioural factors are associated with long-term weight-loss success, the aim of the present study was to determine the prevalence of successful weight loss 15 months post-enrolment in a commercial web-based weight-loss programme and which behavioural factors were associated with success. An online survey was completed 15 months post-enrolment in a commercial web-based weight-loss programme to assess weight-related behaviours and current weight. Participants were classified as successful if they had lost ≥5 % of their starting weight after 15 months. Commercial users of a web-based weight-loss programme. Participants enrolled in the commercial programme between August 2007 and May 2008. Six hundred and seventy-seven participants completed the survey. The median (interquartile range) weight change was -2·7 (-8·2, 1·6) % of enrolment weight, with 37 % achieving ≥5 % weight loss. Multivariate logistic regression analysis found success was associated with frequency of weight self-monitoring, higher dietary restraint score, lower emotional eating score, not skipping meals, not keeping snack foods in the house and eating takeaway foods less frequently. The findings suggest that individuals trying to achieve or maintain ≥5 % weight loss should be advised to regularly weigh themselves, avoid skipping meals or keeping snack foods in the house, limit the frequency of takeaway food consumption, manage emotional eating and strengthen dietary restraint. Strategies to assist individuals make these changes to behaviour should be incorporated within obesity treatments to improve the likelihood of successful weight loss in the long term.

Undersea applications of dexterous robotics

NASA Technical Reports Server (NTRS)

Gittleman, Mark M.

1994-01-01

The revolution and application of dexterous robotics in the undersea energy production industry and how this mature technology has affected planned SSF dexterous robotic tasks are examined. Undersea telerobotics, or Remotely Operated Vehicles (ROV's), have evolved in design and use since the mid-1970s. Originally developed to replace commercial divers for both planned and unplanned tasks, they are now most commonly used to perform planned robotic tasks in all phases of assembly, inspection, and maintenance of undersea structures and installations. To accomplish these tasks, the worksites, the tasks themselves, and the tools are now engineered with both the telerobot's and the diver's capabilities in mind. In many cases, this planning has permitted a reduction in telerobot system complexity and cost. The philosophies and design practices that have resulted in the successful incorporation of telerobotics into the highly competitive and cost conscious offshore production industry have been largely ignored in the space community. Cases where these philosophies have been adopted or may be successfully adopted in the near future are explored.

The UK clinical research network--has it been a success for dermatology clinical trials?

PubMed

Thomas, Kim S; Koller, Karin; Foster, Katharine; Perdue, Jo; Charlesworth, Lisa; Chalmers, Joanne R

2011-06-16

Following the successful introduction of five topic-specific research networks in the UK, the Comprehensive Local Research Network (CLRN) was established in 2008 in order to provide a blanket level of support across the whole country regardless of the clinical discipline. The role of the CLRN was to facilitate recruitment into clinical trials, and to encourage greater engagement in research throughout the National Health Service (NHS). This report evaluates the impact of clinical research networks in supporting clinical trials in the UK, with particular reference to our experiences from two non-commercial dermatology trials. It covers our experience of engaging with the CLRN (and other research networks) using two non-commercial dermatology trials as case studies. We present the circumstances that led to our approach to the research networks for support, and the impact that this support had on the delivery of these trials. In both cases, recruitment was boosted considerably following the provision of additional support, although other factors such as the availability of experienced personnel, and the role of advertising and media coverage in promoting the trials were also important in translating this additional resource into increased recruitment. Recruitment into clinical trials is a complex task that can be influenced by many factors. A world-class clinical research infrastructure is now in place in England (with similar support available in Scotland and Wales), and it is the responsibility of the research community to ensure that this unique resource is used effectively and responsibly.

Adapting Future Wireless Technologies

DTIC Science & Technology

2002-01-01

commercial satellite based systems remains to be proven. Even some of the more commercially successful satellite system (e.g.; the DirecTV direct...Space Data are all looking for private funds without much success . Once funded, estimated time frame for deploying first systems is minimum 3 to 4...of today. It is critical to the mission success that the terrestrial domain of the Army’s C4ISR is based on mobile, ad-hoc, self-healing wireless

Politics, profit, and psychiatric diagnosis: a case study of tobacco use disorder.

PubMed

Hirshbein, Laura D

2014-11-01

The idea of tobacco or nicotine dependence as a specific psychiatric diagnosis appeared in 1980 and has evolved through successive editions of the American Psychiatric Association's Diagnostic and Statistical Manual. Not surprisingly, the tobacco industry attempted to challenge this diagnosis through behind-the-scenes influence. But another entity put corporate muscle into supporting the diagnosis-the pharmaceutical industry. Psychiatry's ongoing professional challenges have left it vulnerable to multiple professional, social, and commercial forces. The example of tobacco use disorder illustrates that mental health concepts used to develop public health goals and policy need to be critically assessed. I review the conflicting commercial, professional, and political aims that helped to construct psychiatric diagnoses relating to smoking. This history suggests that a diagnosis regarding tobacco has as much to do with social and cultural circumstances as it does with science.

Lewis Research Center: Commercialization Success Stories

NASA Technical Reports Server (NTRS)

Heyward, Ann O.

1996-01-01

The NASA Lewis Research Center, located in Cleveland, Ohio, has a portfolio of research and technology capabilities and facilities that afford opportunities for productive partnerships with industry in a broad range of industry sectors. In response to the President's agenda in the area of technology for economic growth (Clinton/Gore 1993), the National Performance Review (1993), NASA's Agenda for Change (1994), and the needs of its customers, NASA Lewis Research Center has sought and achieved significant successes in technology transfer and commercialization. This paper discusses a sampling of Lewis Research Center's successes in this area, and lessons learned that Lewis Research Center is applying in pursuit of continuous improvement and excellence in technology transfer and commercialization.

Are good ideas enough? The impact of socio-economic and regulatory factors on GMO commercialisation.

PubMed

Vàzquez-Salat, Núria

2013-01-01

In recent years scientific literature has seen an increase in publications describing new transgenic applications. Although technically-sound, these promising developments might not necessarily translate into products available to the consumer. This article highlights the impact of external factors on the commercial viability of Genetically Modified (GM) animals in the pharmaceutical and food sectors. Through the division of the production chain into three Policy Domains -Science, Market and Public- I present an overview of the broad range of regulatory and socio-economic components that impacts on the path towards commercialisation of GM animals. To further illustrate the unique combination of forces that influence each application, I provide an in-depth analysis of two real cases: GM rabbits producing human polyclonal antibodies (pharmaceutical case study) and GM cows producing recombinant human lactoferrin (food case study). The inability to generalise over the commercial success of a given transgenic application should encourage researchers to perform these type of exercises early in the R & D process. Furthermore, through the analysis of these case studies we can observe a change in the biopolitics of Genetically Modified Organisms (GMOs). Contrary to the GM plant biopolitical landscape, developing states such as China and Argentina are placing themselves as global leaders in GM animals. The pro-GM attitude of these states is likely to cause a shift in the political evolution of global GMO governance.

Commercialization and the Commercial Internet Exchange: How the CIX Can Help Further the Commercialization of the Internet.

ERIC Educational Resources Information Center

Estrada, Susan

1992-01-01

To promote successful commercialization of the Internet, the Commercial Internet Exchange Association (CIX) acts on behalf of its members to increase cooperation and an open exchange of ideas regarding networking issues. Of concern are federal regulation, development of standards and pricing agreements, and the development of user friendly…

Atlas V Launch Incorporated NASA Glenn Thermal Barrier

NASA Technical Reports Server (NTRS)

Dunlap, Patrick H., Jr.; Steinetz, Bruce M.

2004-01-01

In the Spring of 2002, Aerojet experienced a major failure during a qualification test of the solid rocket motor that they were developing for the Atlas V Enhanced Expendable Launch Vehicle. In that test, hot combustion gas reached the O-rings in the nozzle-to-case joint and caused a structural failure that resulted in loss of the nozzle and aft dome sections of the motor. To improve the design of this joint, Aerojet decided to incorporate three braided carbon-fiber thermal barriers developed at the NASA Glenn Research Center. The thermal barriers were used to block the searing-hot 5500 F pressurized gases from reaching the temperature-sensitive O-rings that seal the joint. Glenn originally developed the thermal barriers for the nozzle joints of the space shuttle solid rocket motors, and Aerojet decided to use them on the basis of the results of several successful ground tests of the thermal barriers in the shuttle rockets. Aerojet undertook an aggressive schedule to redesign the rocket nozzle-to-case joint with the thermal barriers and to qualify it in time for a launch planned for the middle of 2003. They performed two successful qualification tests (Oct. and Dec. 2002) in which the Glenn thermal barriers effectively protected the O-rings. These qualification tests saved hundreds of thousands of dollars in development costs and put the Lockheed-Martin/Aerojet team back on schedule. On July 17, 2003, the first flight of an Atlas V boosted with solid rocket motors successfully launched a commercial satellite into orbit from Cape Canaveral Air Force Station. Aero-jet's two 67-ft solid rocket boosters performed flawlessly, with each providing thrust in excess of 250,000 lbf. Both motors incorporated three Glenn-developed thermal barriers in their nozzle-to-case joints. The Cablevision satellite launched on this mission will be used to provide direct-to-home satellite television programming for the U.S. market starting in late 2003. The Atlas V is a product of the military's Enhanced Expendable Launch Vehicle program designed to provide assured military access to space. It can lift payloads up to 19,100 lb to geosynchronous transfer orbit and was designed to meet Department of Defense, commercial, and NASA needs. The Atlas V and Delta IV are two launch systems being considered by NASA to launch the Orbital Space Plane/Crew Exploration Vehicle. The launch and rocket costs of this mission are valued at $250 million. Successful application of the Glenn thermal barrier to the Atlas V program was an enormous breakthrough for the program's technical and schedule success.

The Crowded Sea: Incorporating Multiple Marine Activities in Conservation Plans Can Significantly Alter Spatial Priorities

PubMed Central

Mazor, Tessa; Possingham, Hugh P.; Edelist, Dori; Brokovich, Eran; Kark, Salit

2014-01-01

Successful implementation of marine conservation plans is largely inhibited by inadequate consideration of the broader social and economic context within which conservation operates. Marine waters and their biodiversity are shared by a host of stakeholders, such as commercial fishers, recreational users and offshore developers. Hence, to improve implementation success of conservation plans, we must incorporate other marine activities while explicitly examining trade-offs that may be required. In this study, we test how the inclusion of multiple marine activities can shape conservation plans. We used the entire Mediterranean territorial waters of Israel as a case study to compare four planning scenarios with increasing levels of complexity, where additional zones, threats and activities were added (e.g., commercial fisheries, hydrocarbon exploration interests, aquaculture, and shipping lanes). We applied the marine zoning decision support tool Marxan to each planning scenario and tested a) the ability of each scenario to reach biodiversity targets, b) the change in opportunity cost and c) the alteration of spatial conservation priorities. We found that by including increasing numbers of marine activities and zones in the planning process, greater compromises are required to reach conservation objectives. Complex plans with more activities incurred greater opportunity cost and did not reach biodiversity targets as easily as simplified plans with less marine activities. We discovered that including hydrocarbon data in the planning process significantly alters spatial priorities. For the territorial waters of Israel we found that in order to protect at least 10% of the range of 166 marine biodiversity features there would be a loss of ∼15% of annual commercial fishery revenue and ∼5% of prospective hydrocarbon revenue. This case study follows an illustrated framework for adopting a transparent systematic process to balance biodiversity goals and economic considerations within a country's territorial waters. PMID:25102177

AED use in a passenger during a long-haul flight: repeated defibrillation with a successful outcome.

PubMed

Harve, Heini; Hämäläinen, Olavi; Kurola, Jouni; Silfvast, Tom

2009-04-01

Sudden cardiac arrest is one of the leading causes of death, and early defibrillation of ventricular fibrillation (VF) is the single most important intervention for improving survival. The automated external defibrillator (AED) and the concept of public access defibrillation provide a solution to shorten defibrillation delays. Commercial aircraft create a unique environment for the use of the AED since an emergency medical service system (EMS) response is not available. We review published studies on this subject and describe the case of a passenger who developed VF during an intercontinental flight and was successfully resuscitated despite recurrent episodes of VF. A 60-yr-old man developed VF during a flight from Tokyo to Helsinki. VF frequently recurred and shocks were delivered 21 times altogether. The aircraft was diverted to the city of Kuopio. When the local EMS crew encountered the patient 3 h after the onset of the cardiac arrest, the rhythm again converted to VF and three further shocks were delivered. The patient recovered, and 3 wk later he was transported to his home country, fully alert. There are three large studies reporting placing AEDs on commercial aircraft. No harm for co-passengers or malfunctions were reported. Survival rates have been higher than those obtained by well-performing EMS. According to previous studies, placing AEDs on commercial aircraft is also cost effective. The absence of a suitable diversion destination should not influence the rescuers' decision to attempt CPR on board.

Electromagnetic Launch Vehicle Fairing and Acoustic Blanket Model of Received Power Using FEKO

NASA Technical Reports Server (NTRS)

Trout, Dawn H.; Stanley, James E.; Wahid, Parveen F.

2011-01-01

Evaluating the impact of radio frequency transmission in vehicle fairings is important to sensitive spacecraft. This paper employees the Multilevel Fast Multipole Method (MLFMM) feature of a commercial electromagnetic tool to model the fairing electromagnetic environment in the presence of an internal transmitter. This work is an extension of the perfect electric conductor model that was used to represent the bare aluminum internal fairing cavity. This fairing model includes typical acoustic blanketing commonly used in vehicle fairings. Representative material models within FEKO were successfully used to simulate the test case.

R&D to Market Success: BTO-Supported Technologies Commercialized from 2010-2015

DOE Office of Scientific and Technical Information (OSTI.GOV)

None, None

2017-04-01

Technology commercialization plays an essential role in almost every facet of the U.S. economy. It spurs private sector funding that supports innovative breakthroughs, drives growth through increased productivity and product development, increases American competitiveness, and creates domestic jobs. The BTO Technology Commercialization report is an annual publication offering the latest information on successfully commercialized technologies resulting in part from BTO’s research partnerships. This report defines a “commercialized technology” as a process, technique, design, machine, tool, material, or software that was developed with funds provided at least in part by BTO, and that has resulted in domestic sales or is inmore » use in the U.S. This definition also applies to open-source software products developed with support from BTO, all of which are currently distributed freely but are actively used for commercial purposes.« less

Advanced Tissue Sciences Inc.: learning from the past, a case study for regenerative medicine.

PubMed

Pangarkar, Nitin; Pharoah, Marc; Nigam, Avinav; Hutmacher, Dietmar W; Champ, Simon

2010-09-01

On 31st March 2003 Advanced Tissue Sciences (ATS) was liquidated, with the effect that in excess of US$300 million of stakeholder financing was destroyed. Although successful in the development of breakthrough technologies in the regenerative medicine arena and the building of a substantial portfolio of patents, the company never made a profit. In this case study, ATS’ business strategy, market and competitive environment will be discussed in the context of the company’s historical development. A number of important lessons from this case are discussed. From a management perspective the most critical lesson is the importance of effective financial planning and management of costs, and in particular R&D costs, including the significant costs associated with clinical trials. In addition, a clear strategic focus is extremely important due to the significant resources required in the development of a new therapy. From an investor’s perspective the lessons to be gathered from the ATS case are related to the risk involved in investing in the field of regenerative medicine. This case indicates that both professional and private investors did not fully question the validity of ATS’ business strategy and financial forecasts. A clear and focused strategy based on long-term investor commitment is essential for the successful commercialization of regenerative medicine.

Informatics in radiology (infoRAD): Vendor-neutral case input into a server-based digital teaching file system.

PubMed

Kamauu, Aaron W C; DuVall, Scott L; Robison, Reid J; Liimatta, Andrew P; Wiggins, Richard H; Avrin, David E

2006-01-01

Although digital teaching files are important to radiology education, there are no current satisfactory solutions for export of Digital Imaging and Communications in Medicine (DICOM) images from picture archiving and communication systems (PACS) in desktop publishing format. A vendor-neutral digital teaching file, the Radiology Interesting Case Server (RadICS), offers an efficient tool for harvesting interesting cases from PACS without requiring modifications of the PACS configurations. Radiologists push imaging studies from PACS to RadICS via the standard DICOM Send process, and the RadICS server automatically converts the DICOM images into the Joint Photographic Experts Group format, a common desktop publishing format. They can then select key images and create an interesting case series at the PACS workstation. RadICS was tested successfully against multiple unmodified commercial PACS. Using RadICS, radiologists are able to harvest and author interesting cases at the point of clinical interpretation with minimal disruption in clinical work flow. RSNA, 2006

Purity assessment of commercial zein products after purification

USDA-ARS?s Scientific Manuscript database

Successful utilization of commercial zein products for certain food, pharmaceutical, cosmetic and medical applications requires a decolorized/deodorized zein of high purity. A zein protein product with those qualifications can be achieved by column filtration of commercial yellow zein solutions thro...

Sunlight-readable display technology: a dual-use case study

NASA Astrophysics Data System (ADS)

Blanchard, Randall D.

1996-05-01

This paper describes our vision of sunlight readable color display requirements, an alternate technology that offers a high level of performance, and how we implemented it for the military avionics display market. This knowledge base and product development experience was then applied with a comparable level of performance to commercial applications. The successful dual use of this technology for these two diverse markets is presented. Details of the technical commonality and a comparison of the design and performance differences are presented. A basis for specifying the required level of performance for a sunlight readable full color display is discussed. With the objective of providing a high level of image brightness and high ambient light rejection, a display architecture using collimated light is used. The resulting designs of two military cockpit display products, with contrast ratios above 20:1 in sunlight are shown. The performance of a commercial display providing several thousand foot- Lamberts of image brightness is presented.

Effects of microgravity on cognition: The case of mental imagery.

PubMed

Grabherr, Luzia; Mast, Fred W

2010-01-01

Human cognitive performance is an important factor for the successful and safe outcome of commercial and non-commercial manned space missions. This article aims to provide a systematic review of studies investigating the effects of microgravity on the cognitive abilities of parabolic or space flight participants due to the absence of the gravito-inertial force. We will focus on mental imagery: one of the best studied cognitive functions. Mental imagery is closely connected to perception and motor behavior. It aids important processes such as perceptual anticipation, problem solving and motor simulation, all of which are critical for space travel. Thirteen studies were identified and classified into the following topics: spatial representations, mental image transformations and motor imagery. While research on spatial representation and mental image transformation continues to grow and specific differences in cognitive functioning between 1 g and 0 g have been observed, motor imagery has thus far received little attention.

Politics, Profit, and Psychiatric Diagnosis: A Case Study of Tobacco Use Disorder

PubMed Central

2014-01-01

The idea of tobacco or nicotine dependence as a specific psychiatric diagnosis appeared in 1980 and has evolved through successive editions of the American Psychiatric Association’s Diagnostic and Statistical Manual. Not surprisingly, the tobacco industry attempted to challenge this diagnosis through behind-the-scenes influence. But another entity put corporate muscle into supporting the diagnosis—the pharmaceutical industry. Psychiatry’s ongoing professional challenges have left it vulnerable to multiple professional, social, and commercial forces. The example of tobacco use disorder illustrates that mental health concepts used to develop public health goals and policy need to be critically assessed. I review the conflicting commercial, professional, and political aims that helped to construct psychiatric diagnoses relating to smoking. This history suggests that a diagnosis regarding tobacco has as much to do with social and cultural circumstances as it does with science. PMID:25211741

Challenges to the introduction of new technologies to dental practice.

PubMed

Barnett, Michael L

2006-01-01

Despite promising breakthroughs in basic biomedical science, the pace at which innovative and disruptive new technologies are developed and introduced into dental practice lags behind that of medicine. This is largely a result of resource issues, both financial and human, as well as determinants in the marketplace. For example, the cost of developing a new drug or technology for dentistry and bringing it to market is often disproportionably high relative to the size of the dental market, thereby making it commercially unfeasible to pursue development. When a new technology is commercialized, its successful introduction can be facilitated by research that makes a compelling case for effective use. As our understanding of mechanisms of disease pathogenesis progresses, identifying compounds and technologies with applicability to both oral and systemic diseases could change the economics of dental product development and lead to additional innovative advances in our field.

Vibrio infections and surveillance in Maryland, 2002-2008.

PubMed

Jones, Erin H; Feldman, Katherine A; Palmer, Amanda; Butler, Erin; Blythe, David; Mitchell, Clifford S

2013-01-01

Vibrio is a naturally occurring waterborne pathogen with potential occupational, recreational, and commercial impacts. During the last 15 years in the U.S. and in Maryland, the incidence of vibriosis has increased. Due to the increase in cases in Maryland, warming water temperatures, and public concern about human health effects resulting from exposure to the Chesapeake Bay, we reviewed cases of vibriosis and evaluated the Vibrio surveillance system in Maryland for timeliness and data quality, attributes necessary for successful outbreak investigation and illness prevention. The evaluation included (1) informal qualitative surveys of state and local personnel who report and manage Vibrio cases and (2) a review of Vibrio surveillance data from 2002 through 2008 for data quality and timeliness of the system. From 2002 to 2008, 188 laboratory-confirmed cases of vibriosis were reported in Maryland with an annual average of 27 cases. The species of Vibrio that were most frequently responsible for infection, regardless of clinical presentation, were V. parahaemolyticus (43.6%), V. vulnificus (23.9%), V. alginolyticus (9.6%), and non-toxigenic V. cholerae (9.0%). The case fatality rate fluctuated during the study period, but the number of cases increased. The surveillance system in Maryland is flexible and captures cases of vibriosis where specimens were collected for testing; however, the system may not adequately capture mild, self-limiting infections. Better integration of data collection for clinical, laboratory, and environmental information and improved completion of variables for shellfish harvest or water exposure locations could improve the system. Quarterly meetings comprising surveillance, public health laboratory, and food-control personnel could direct and ensure the success of improvement efforts.

Why good ideas and good science do not always make it into the marketplace

Treesearch

Charles R. Frihart

2007-01-01

Good ideas and good science are not sufficient in and of themselves for successful commercialization of new technology. Understanding the barriers to commercialization so that ways around, under, over, or through them can be found is also crucial to success. Barriers can include market needs, technology push versus market pull, availability of a window of opportunity,...

Preventing Commercial Colonialism and Retaining Sovereignty Over National Policy and Military Strategy in Space

DTIC Science & Technology

2018-04-09

29 National Interests in Space – Commercial or State-Driven Celestial Expansion? ....... 31 Celestial Market Opportunities – When Will Commercial...Space Markets Open? ...... 38 Implications of Commercial Space Operations ............................................................ 45 Chapter 5...Successful development of competitiveness involves seeking to dominate or control an existing or emergent market . The development of market domination into

The cost of getting CCS wrong: Uncertainty, infrastructure design, and stranded CO 2

DOE PAGES

Middleton, Richard Stephen; Yaw, Sean Patrick

2018-01-11

Carbon capture, and storage (CCS) infrastructure will require industry—such as fossil-fuel power, ethanol production, and oil and gas extraction—to make massive investment in infrastructure. The cost of getting these investments wrong will be substantial and will impact the success of CCS technology. Multiple factors can and will impact the success of commercial-scale CCS, including significant uncertainties regarding capture, transport, and injection-storage decisions. Uncertainties throughout the CCS supply chain include policy, technology, engineering performance, economics, and market forces. In particular, large uncertainties exist for the injection and storage of CO 2. Even taking into account upfront investment in site characterization, themore » final performance of the storage phase is largely unknown until commercial-scale injection has started. We explore and quantify the impact of getting CCS infrastructure decisions wrong based on uncertain injection rates and uncertain CO 2 storage capacities using a case study managing CO 2 emissions from the Canadian oil sands industry in Alberta. We use SimCCS, a widely used CCS infrastructure design framework, to develop multiple CCS infrastructure scenarios. Each scenario consists of a CCS infrastructure network that connects CO 2 sources (oil sands extraction and processing) with CO 2 storage reservoirs (acid gas storage reservoirs) using a dedicated CO 2 pipeline network. Each scenario is analyzed under a range of uncertain storage estimates and infrastructure performance is assessed and quantified in terms of cost to build additional infrastructure to store all CO 2. We also include the role of stranded CO 2, CO 2 that a source was expecting to but cannot capture due substandard performance in the transport and storage infrastructure. Results show that the cost of getting the original infrastructure design wrong are significant and that comprehensive planning will be required to ensure that CCS becomes a successful climate mitigation technology. Here, we show that the concept of stranded CO 2 can transform a seemingly high-performing infrastructure design into the worst case scenario.« less

The cost of getting CCS wrong: Uncertainty, infrastructure design, and stranded CO 2

DOE Office of Scientific and Technical Information (OSTI.GOV)

Middleton, Richard Stephen; Yaw, Sean Patrick

Carbon capture, and storage (CCS) infrastructure will require industry—such as fossil-fuel power, ethanol production, and oil and gas extraction—to make massive investment in infrastructure. The cost of getting these investments wrong will be substantial and will impact the success of CCS technology. Multiple factors can and will impact the success of commercial-scale CCS, including significant uncertainties regarding capture, transport, and injection-storage decisions. Uncertainties throughout the CCS supply chain include policy, technology, engineering performance, economics, and market forces. In particular, large uncertainties exist for the injection and storage of CO 2. Even taking into account upfront investment in site characterization, themore » final performance of the storage phase is largely unknown until commercial-scale injection has started. We explore and quantify the impact of getting CCS infrastructure decisions wrong based on uncertain injection rates and uncertain CO 2 storage capacities using a case study managing CO 2 emissions from the Canadian oil sands industry in Alberta. We use SimCCS, a widely used CCS infrastructure design framework, to develop multiple CCS infrastructure scenarios. Each scenario consists of a CCS infrastructure network that connects CO 2 sources (oil sands extraction and processing) with CO 2 storage reservoirs (acid gas storage reservoirs) using a dedicated CO 2 pipeline network. Each scenario is analyzed under a range of uncertain storage estimates and infrastructure performance is assessed and quantified in terms of cost to build additional infrastructure to store all CO 2. We also include the role of stranded CO 2, CO 2 that a source was expecting to but cannot capture due substandard performance in the transport and storage infrastructure. Results show that the cost of getting the original infrastructure design wrong are significant and that comprehensive planning will be required to ensure that CCS becomes a successful climate mitigation technology. Here, we show that the concept of stranded CO 2 can transform a seemingly high-performing infrastructure design into the worst case scenario.« less

Commercial Buildings Partnerships - Overview of Higher education projects

DOE Office of Scientific and Technical Information (OSTI.GOV)

Parrish, Kristen; Robinson, Alastair; Regnier, Cindy

2013-02-01

The Commercial Building Partnership (CBP), a public/private, cost-shared program sponsored by the U.S. Department of Energy (DOE), paired selected commercial building owners and operators with representatives of DOE, its national laboratories, and private-sector technical experts. These teams explored energy-saving measures across building systems – including some considered too costly or technologically challenging – and used advanced energy modeling to achieve peak whole-building performance. Modeling results were then included in new construction or retrofit designs to achieve significant energy reductions. CBP design goals aimed to achieve 50 percent energy savings compared to ANSI/ASHRAE/IES Standard 90.1-2004 for new construction, while retrofits aremore » designed to consume at least 30 percent less energy than either Standard 90.1-2004 or current consumption. After construction and commissioning of the project, laboratory staff continued to work with partners to collect and analyze data for verification of the actual energy reduction. CBP projects represent diverse building types in commercial real estate, including lodging, grocery, retail, higher education, office, and warehouse/storage facilities. Partners also commit to replicating low-energy technologies and strategies from their CBP projects throughout their building portfolios. As a result of CBP projects, five sector overviews (Lodging, Food Sales, General Merchandise, Higher Education, Offices) were created to capture successful strategies and recommended energy efficiency measures that could broadly be applied across these sectors. These overviews are supplemented with individual case studies providing specific details on the decision criteria, modeling results, and lessons learned on specific projects. Sector overviews and CBP case studies will also be updated to reflect verified data and replication strategies as they become available.« less

Bypassing Bypass Surgery and Other Success Stories from the National Institutes of Health

PubMed Central

Nijhara, Ruchika; Tidwell, J. Lille; Ferguson, Steven; Balakrishnan, Krishna

2009-01-01

After a heart attack, patients often undergo a procedure to open up the clogged artery and install a tiny meshlike device called a stent to keep the artery propped open. In most cases, the body reacts to this foreign object with scar-tissue formation, and the artery narrows again. To combat this re-clogging process, National Institutes of Health inventors developed paclitaxel-coated stents and later licensed it to Angiotech. Approved by the Food and Drug Administration in March 2004, these stents are expected to substantially reduce the use of coronary artery bypass surgery, an expensive operation now performed annually on 350,000-plus Americans. This and three other examples of NIH licensing success stories are described in this paper: (a) Kepivance, which improves the quality of life for cancer patients by eliminating mouth sores, (b) AIDS drug ddI, an important component of many combination drug therapies, and (c) Vitravene, the first and only antisense drug to be approved by FDA. These four examples will illustrate the success not only of the NIH licensing program, but also the innovative approaches taken by NIH inventors and the persistence of its commercial partners. This paper also highlights the business and legal lessons learned from these four cases. PMID:23730679

DNA extraction and barcode identification of development stages of forensically important flies in the Czech Republic.

PubMed

Olekšáková, Tereza; Žurovcová, Martina; Klimešová, Vanda; Barták, Miroslav; Šuláková, Hana

2018-04-01

Several methods of DNA extraction, coupled with 'DNA barcoding' species identification, were compared using specimens from early developmental stages of forensically important flies from the Calliphoridae and Sarcophagidae families. DNA was extracted at three immature stages - eggs, the first instar larvae, and empty pupal cases (puparia) - using four different extraction methods, namely, one simple 'homemade' extraction buffer protocol and three commercial kits. The extraction conditions, including the amount of proteinase K and incubation times, were optimized. The simple extraction buffer method was successful for half of the eggs and for the first instar larval samples. The DNA Lego Kit and DEP-25 DNA Extraction Kit were useful for DNA extractions from the first instar larvae samples, and the DNA Lego Kit was also successful regarding the extraction from eggs. The QIAamp DNA mini kit was the most effective; the extraction was successful with regard to all sample types - eggs, larvae, and pupari.

Results from an exploratory study to identify the factors that contribute to success for UK medical device small- and medium-sized enterprises.

PubMed

Hourd, P C; Williams, D J

2008-07-01

This paper reports the results from an exploratory study that sets out to identify and compare the strategic approaches and patterns of business practice employed by 14 UK small- and medium-sized enterprises to achieve success in the medical device sector of the health-care industry. An interview-based survey was used to construct individual case studies of the medical device technology (MDT) companies. A cross-case analysis was performed to search for patterns and themes that cut across these individual cases. Exploratory results revealed the heterogeneity of MDT companies and the distinctive features of the MDT innovation process that emphasize the importance of a strategic approach for achieving milestones in the product development and exploitation process and for creating value for the company and its stakeholders. Recognizing the heterogeneity of MDT companies, these exploratory findings call for further investigation to understand better the influence of components of the MDT innovation process on the commercialization life cycle and value trajectory. This is required to assist start-up or spin-out MDT companies in the UK and worldwide to navigate the critical transitions that determine access to financial and consumer markets and enhance the potential to build a successful business. This will be important not only for bioscience-based companies but also for engineering-based companies aiming to convert their activities into medical devices and the health- and social-care market.

A hypertext system that learns from user feedback

NASA Technical Reports Server (NTRS)

Mathe, Nathalie

1994-01-01

Retrieving specific information from large amounts of documentation is not an easy task. It could be facilitated if information relevant in the current problem solving context could be automatically supplied to the user. As a first step towards this goal, we have developed an intelligent hypertext system called CID (Computer Integrated Documentation). Besides providing an hypertext interface for browsing large documents, the CID system automatically acquires and reuses the context in which previous searches were appropriate. This mechanism utilizes on-line user information requirements and relevance feedback either to reinforce current indexing in case of success or to generate new knowledge in case of failure. Thus, the user continually augments and refines the intelligence of the retrieval system. This allows the CID system to provide helpful responses, based on previous usage of the documentation, and to improve its performance over time. We successfully tested the CID system with users of the Space Station Freedom requirements documents. We are currently extending CID to other application domains (Space Shuttle operations documents, airplane maintenance manuals, and on-line training). We are also exploring the potential commercialization of this technique.

Law enforcement-applied tourniquets: a case series of life-saving interventions.

PubMed

Callaway, David W; Robertson, Joshua; Sztajnkrycer, Matthew D

2015-01-01

Although the epidemiology of civilian trauma is distinct from that encountered in combat, in both settings, extremity hemorrhage remains a major preventable cause of potential mortality. The current paper describes the largest case series in the literature in which police officers arriving prior to emergency medical services applied commercially available field tourniquets to civilian victims of violent trauma. Although all 3 patients with vascular injury arrived at the receiving emergency department in extremis, they were successfully resuscitated and survived to discharge without major morbidity. While this outcome is likely multifactorial and highlights the exceptional care delivered by the modern trauma system, tourniquet application appears to have kept critically injured patients alive long enough to reach definitive trauma care. No patient had a tourniquet-related complication. This case series suggests that law enforcement officers can effectively identify indications for tourniquets and rapidly apply such life-saving interventions.

Commercial Contributions to the Success of the HEDS Enterprise: A Working Model

NASA Technical Reports Server (NTRS)

Nall, Mark; Askew, Ray

2000-01-01

The future of NASA involves the exploration of space beyond the confines of orbit about the Earth. This includes robotic investigations and Human Exploration and Development of Space (HEDS). The HEDS Strategic Plan states: "HEDS will join with the private sector to stimulate opportunities for commercial development in space as a key to future settlement. Near-term efforts will emphasize joint pilot projects that provide clear benefit to Earth from the development of near-Earth space." In support of this endeavor, NASA has established the Commercial Development of Space as a prime goal and is exploring all the ways in which NASA might make contributions to this development. NASA has long supported the development of space for commercial use. In 1985 it formally established and provided funds to support a program which created a number of joint ventures between universities and industry for this purpose. These were known as Centers for the Commercial Development of Space (CCDS). In 1999 NASA established a broader policy on commercialization with the aim of encouraging near-term commercial investment in conjunction with the International Space Station. Joint pilot projects will be initiated to stimulate this near-term investment. The long-term development of commercial concepts utilizing space access continues through the activities of the Commercial Space Centers (CSC), a sub-set of the original CCDS group. These Centers primarily require access to space for the conduct of their work. The remainder of the initial Centers focus on the development of tools and infrastructure to support users of the space environment. It is in this arena that long term development for commercial use and infrastructure development will occur. This paper will provide a retrospective examination of the Commercial Centers, the variety of models employed, the lessons learned, and the progress to date. This review will provide the bases for how successful models can be employed to accelerate private investment in the development of the infrastructure necessary for the success of the HEDS enterprise.

Geographically widespread swordfish barcode stock identification: a case study of its application.

PubMed

Pappalardo, Anna Maria; Guarino, Francesca; Reina, Simona; Messina, Angela; De Pinto, Vito

2011-01-01

The swordfish (Xiphias gladius) is a cosmopolitan large pelagic fish inhabiting tempered and tropical waters and it is a target species for fisheries all around the world. The present study investigated the ability of COI barcoding to reliably identify swordfish and particularly specific stocks of this commercially important species. We applied the classical DNA barcoding technology, upon a 682 bp segment of COI, and compared swordfish sequences from different geographical sources (Atlantic, Indian Oceans and Mediterranean Sea). The sequences of the 5' hyper-variable fragment of the control region (5'dloop), were also used to validate the efficacy of COI as a stock-specific marker. This information was successfully applied to the discrimination of unknown samples from the market, detecting in some cases mislabeled seafood products. The NJ distance-based phenogram (K2P model) obtained with COI sequences allowed us to correlate the swordfish haplotypes to the different geographical stocks. Similar results were obtained with 5'dloop. Our preliminary data in swordfish Xiphias gladius confirm that Cytochrome Oxidase I can be proposed as an efficient species-specific marker that has also the potential to assign geographical provenance. This information might speed the samples analysis in commercial application of barcoding.

Two years' experience with Web-based teleconsulting in dermatology.

PubMed

Massone, C; Soyer, H P; Hofmann-Wellenhof, R; Di Stefani, A; Lozzi, G P; Gabler, G; Dong, H; Argenziano, G; Ozdemir, F; Fink-Puches, R; Salmhofer, W; Zalaudek, I; Nunzi, E; Kerl, H

2006-01-01

A non-commercial teledermatology network based on store-and-forward operation was established in April 2002. The aim was to create an easy-to-use platform for teleconsultation services, where physicians could seek diagnostic advice in dermatology from a pool of expert consultants and where they could present and discuss challenging dermatology cases with special emphasis on diagnosis and therapy. An online moderated discussion forum was added in October 2003. During the first two years, 348 health-care professionals from 45 countries registered to use the Website. A total of 783 requests for consultations were answered; 285 requests concerned pigmented skin lesions, 440 requests were from the whole range of clinical dermatology and 58 requests were about non-melanoma skin cancer. Of a total of 133 requests analysed, 80 (60%) were answered within one day, 47 (35%) within one week, five (4%) within two weeks and one (1%) consultation was answered in more than two weeks. Our experience with a discretionary, non-commercial, multilingual Website for open-access teleconsulting in dermatology appears to be successful. The Website represents an example of user-generated content, together with active interaction between users, who can present and discuss cases with remote colleagues.

Clinical Validation of Targeted Next Generation Sequencing for Colon and Lung Cancers

PubMed Central

D’Haene, Nicky; Le Mercier, Marie; De Nève, Nancy; Blanchard, Oriane; Delaunoy, Mélanie; El Housni, Hakim; Dessars, Barbara; Heimann, Pierre; Remmelink, Myriam; Demetter, Pieter; Tejpar, Sabine; Salmon, Isabelle

2015-01-01

Objective Recently, Next Generation Sequencing (NGS) has begun to supplant other technologies for gene mutation testing that is now required for targeted therapies. However, transfer of NGS technology to clinical daily practice requires validation. Methods We validated the Ion Torrent AmpliSeq Colon and Lung cancer panel interrogating 1850 hotspots in 22 genes using the Ion Torrent Personal Genome Machine. First, we used commercial reference standards that carry mutations at defined allelic frequency (AF). Then, 51 colorectal adenocarcinomas (CRC) and 39 non small cell lung carcinomas (NSCLC) were retrospectively analyzed. Results Sensitivity and accuracy for detecting variants at an AF >4% was 100% for commercial reference standards. Among the 90 cases, 89 (98.9%) were successfully sequenced. Among the 86 samples for which NGS and the reference test were both informative, 83 showed concordant results between NGS and the reference test; i.e. KRAS and BRAF for CRC and EGFR for NSCLC, with the 3 discordant cases each characterized by an AF <10%. Conclusions Overall, the AmpliSeq colon/lung cancer panel was specific and sensitive for mutation analysis of gene panels and can be incorporated into clinical daily practice. PMID:26366557

Successful commercialization of nanophotonic technology

NASA Astrophysics Data System (ADS)

Jaiswal, Supriya L.; Clarke, Roger B. M.; Hyde, Sam C. W.

2006-08-01

The exploitation of nanotechnology from proof of principle to realizable commercial applications encounters considerable challenges in regards to high volume, large scale, low cost manufacturability and social ethics. This has led to concerns over converting powerful intellectual property into realizable, industry attractive technologies. At The Technology Partnership we specifically address the issue of successful integration of nanophotonics into industry in markets such as biomedical, ophthalmic, energy, telecommunications, and packaging. In this paper we draw on a few examples where we have either developed industrial scale nanophotonic technology or engineering platforms which may be used to fortify nano/microphotonic technologies and enhance their commercial viability.

Entry order as a consideration for innovation strategies.

PubMed

Cohen, Fredric J

2006-04-01

Prior studies have defined an effect of market entry order on commercial success that depends on attributes of the underlying technology, the rate of change in technology improvement, consumer expectations of these attributes and the degree of unmet demand. Analyses of pharmaceutical sales data suggest that the commercial success of drugs is subject to similar forces. These findings have important implications for innovation strategies.

Women who sell sex in a Ugandan trading town: life histories, survival strategies and risk.

PubMed

Gysels, Marjolein; Pool, Robert; Nnalusiba, Betty

2002-01-01

Little is known about the background of commercial sex workers in Africa. This study investigated how women in a trading town on the trans-Africa highway in southwest Uganda become involved in commercial sex work, which factors contribute to their economic success or lack of success, and what effect life trajectories and economic success have on negotiating power and risk behaviour. Over the course of two years detailed life histories of 34 women were collected through recording open, in-depth interviews, the collection of sexual and income and expenditure diaries, visits to the women's native villages, and participant observation. The women share similar disadvantaged backgrounds and this has played a role in their move into commercial sex. They have divergent experiences, however, in their utilisation of opportunities and in the level of success they achieve. They have developed different life styles and a variety of ways of dealing with sexual relationships. Three groups of women were identified: (1) women who work in the back-street bars, have no capital of their own and are almost entirely dependent on selling sex for their livelihood; (2) waitresses in the bars along the main road who engage in a more institutionalised kind of commercial sex, often mediated by middlemen and (3) the more successful entrepreneurs who earn money from their own bars as well as from commercial sex. The three groups had different risk profiles. Due partly to their financial independence from men, women in the latter group have taken control of sexual relationships and can negotiate good sexual deals for themselves, both financially and in terms of safe sex. The poorer women were more vulnerable and less able to negotiate safer sex. A disadvantaged background and restricted access to economic resources are the major reasons for women gravitating to commercial sex work. Various aspects of personality play a role in utilising income from commercial sex to set up an economic basis that then makes the selling of sex unnecessary. This has implications for interventions, and part of the longer-term solution should lie in improving the economic position of women vis-à-vis men.

LULL(ed) into complacency: a perspective on licenses and stem cell translational science

PubMed Central

2013-01-01

The US has had a very successful model for facilitating the translation of a basic discovery to a commercial application. The success of the model has hinged on providing clarity on ownership of a discovery, facilitating the licensing process, providing adequate incentive to the inventors, and developing a self-sustaining model for reinvestment. In recent years, technological, political, and regulatory changes have put strains on this model and in some cases have hindered progress rather than facilitated it. This is particularly true for the nascent field of regenerative medicine. To illustrate this, I will describe the contributing practices of several different entities, including universities, repositories, patent trolls, and service providers. It is my hope that the scientific community will be motivated to coordinate efforts against these obstacles to translation. PMID:23953837

Intensification through diversified resource use: the human ecology of a successful agricultural industry in Indonesian Borneo

DOE Office of Scientific and Technical Information (OSTI.GOV)

Vondal, P.J.

1987-03-01

The success of an agricultural industry in commercial duck egg production in the swamplands of South Kalimantan (Borneo) is examined through the utilization of a human ecology framework. Seasonality of resource availability and human population growth are identified as two major constraints to production faced by farmers. Population increases in the urban sectors of southeastern Borneo also present economic opportunities for farmers because of the growing demand for poultry products. Farmers have responded by developing an intensification strategy in egg production based on the use of diversified resources for duck feed. The long-term consequences of these and other innovations inmore » duck farming are discussed; and diversity-stability theory is examined for its applicability to this case of agricultural development and for rural development theory and practice.« less

Acetylation of loofa (Luffa cylindrica) sponge as immobilization carrier for bioprocesses involving cellulase.

PubMed

Hideno, Akihiro; Ogbonna, James C; Aoyagi, Hideki; Tanaka, Hideo

2007-04-01

The feasibility of using loofa sponge for immobilization of cellulase-producing microorganisms was investigated by acetylating loofa sponge. Acetylation was achieved by autoclaving process of loofa sponge immersed in acetic anhydride at various temperatures for various times. The degree of acetylation, as inferred by the weight percentage gain (WPG), was enhanced by increasing both temperature and the duration of acetylation. The acetylation of a piece of loofa sponge in an autoclave at 120 degrees C for 20 min resulted in a WPG of about 8%, which was sufficient to protect the loofa sponge against cellulose degradation. The acetylated loofa sponge prepared under this condition was not decomposed by commercial cellulase and its structure was maintained for more than 720 h during repeated-batch treatments with commercial cellulase. A flocculating yeast (Saccharomyces cerevisiae IR-2) and a fungus (Trichoderma reesei QM9414) were successfully immobilized in the acetylated loofa sponge. In each case, the percentage of immobilized cells was as high as that obtained using nonacetylated loofa sponge. Acetylation had no adverse effects on cell growth and immobilization of T. reesei QM9414, as well as on cell growth and ethanol production by S. cerevisiae IR-2. T. reesei QM9414 immobilized on an acetylated loofa sponge was successfully used for repeated-batch cellulase production from commercial cellulose powder. Although the acetylated loofa sponge showed a slight weight loss, it was not disintegrated by activated sludge. The results obtained in this study showed that acetylated loofa sponge is suitable as an immobilization carrier for bioprocesses involving cellulase.

Let native species take their course: Ambrosia artemisiifolia replacement during natural or ;artificial; succession

NASA Astrophysics Data System (ADS)

Gentili, Rodolfo; Montagnani, Chiara; Gilardelli, Federica; Guarino, Maria Francesca; Citterio, Sandra

2017-07-01

Ambrosia artemisiifolia is able to dominate the early stages of vegetation succession in open/disturbed habitats, spreading out into available empty niches, after which it can be progressively replaced by perennial plants. In this study, we considered the time-span in which the species is suppressed during active (restoration actions) and passive (spontaneous) vegetation recovery. In particular, we envisaged that A. artemisiifolia growth and fitness may be strongly reduced and that the species may rapidly be suppressed within a short time during succession as a consequence of the increase of vegetation cover, both natural or artificially induced, in a disturbed area of northern Italy. Three different treatments were applied within an abandoned quarry area commonly invaded by A. artemisiifolia: (i) spontaneous succession i.e. (control), (ii) hayseed and (iii) a commercial seed mixture. We determined the effect of mixtures of grassland species, established from native hayseed or from a commercial seed mixture, on A. artemisiifolia growth and fitness traits over time in comparison to a non-seeded area left to spontaneous succession. The results demonstrated that, after the first growing season, compared with spontaneous succession, both commercial seed and hayseed resulted in a strong reduction of A. artemisiifolia abundance and growth rate, in terms of both vegetative and reproductive traits. After the second growing season, A. artemisiifolia was completely suppressed in the commercial seed treatment, and after the third growing season it was also suppressed in the spontaneous succession and hayseed treatments. This study indicated that both active and passive vegetation recovery (by niche filling and competitive exclusion) could be used as methods individually or in combination with other methods, such as mowing and biological control, to suppress A. artemisiifolia from anthropogenic habitats.

Agromining: farming for metals in the future?

PubMed

van der Ent, Antony; Baker, Alan J M; Reeves, Roger D; Chaney, Rufus L; Anderson, Christopher W N; Meech, John A; Erskine, Peter D; Simonnot, Marie-Odile; Vaughan, James; Morel, Jean Louis; Echevarria, Guillaume; Fogliani, Bruno; Rongliang, Qiu; Mulligan, David R

2015-04-21

Phytomining technology employs hyperaccumulator plants to take up metal in harvestable plant biomass. Harvesting, drying and incineration of the biomass generates a high-grade bio-ore. We propose that "agromining" (a variant of phytomining) could provide local communities with an alternative type of agriculture on degraded lands; farming not for food crops, but for metals such as nickel (Ni). However, two decades after its inception and numerous successful experiments, commercial phytomining has not yet become a reality. To build the case for the minerals industry, a large-scale demonstration is needed to identify operational risks and provide "real-life" evidence for profitability.

Advanced Transport Operating Systems Program

NASA Technical Reports Server (NTRS)

White, John J.

1990-01-01

NASA-Langley's Advanced Transport Operating Systems Program employs a heavily instrumented, B 737-100 as its Transport Systems Research Vehicle (TRSV). The TRSV has been used during the demonstration trials of the Time Reference Scanning Beam Microwave Landing System (TRSB MLS), the '4D flight-management' concept, ATC data links, and airborne windshear sensors. The credibility obtainable from successful flight test experiments is often a critical factor in the granting of substantial commitments for commercial implementation by the FAA and industry. In the case of the TRSB MLS, flight test demonstrations were decisive to its selection as the standard landing system by the ICAO.

Imiglucerase in the treatment of Gaucher disease: a history and perspective

PubMed Central

Deegan, Patrick B; Cox, Timothy M

2012-01-01

The scientific and therapeutic development of imiglucerase (Cerezyme®) by the Genzyme Corporation is a paradigm case for a critical examination of current trends in biotechnology. In this article the authors argue that contemporary interest in treatments for rare diseases by major pharmaceutical companies stems in large part from an exception among rarities: the astonishing commercial success of Cerezyme. The fortunes of the Genzyme Corporation, latterly acquired by global giant Sanofi SA, were founded on the evolution of a blockbuster therapy for a single but, as it turns out, propitious ultra-orphan disorder: Gaucher disease. PMID:22563238

Combinations of biocontrol agents for management of plant-parasitic nematodes and soilborne plant-pathogenic fungi.

PubMed

Meyer, Susan L F; Roberts, Daniel P

2002-03-01

Numerous microbes are antagonistic to plant-parasitic nematodes and soilborne plant-pathogenic fungi, but few of these organisms are commercially available for management of these pathogens. Inconsistent performance of applied biocontrol agents has proven to be a primary obstacle to the development of successful commercial products. One of the strategies for overcoming inconsistent performance is to combine the disease-suppressive activity of two (or more) beneficial microbes in a biocontrol preparation. Such combinations have potential for more extensive colonization of the rhizosphere, more consistent expression of beneficial traits under a broad range of soil conditions, and antagonism to a larger number of plant pests or pathogens than strains applied individually. Conversely, microbes applied in combination also may have antagonistic interactions with each other. Increased, decreased, and unaltered suppression of the target pathogen or pest has been observed when biocontrol microbes have been applied in combination. Unfortunately, the ecological basis for increased or decreased suppression has not been determined in many cases and needs further consideration. The complexity of interactions involved in the application of multiple organisms for biological control has slowed progress toward development of successful formulations. However, this approach has potential for overcoming some of the efficacy problems that occur with application of individual biocontrol agents.

Marking emergency exits and evacuation routes with sound beacons utilizing the precedence effect

NASA Astrophysics Data System (ADS)

van Wijngaarden, Sander J.; Bronkhorst, Adelbert W.; Boer, Louis C.

2004-05-01

Sound beacons can be extremely useful during emergency evacuations, especially when vision is obscured by smoke. When exits are marked with suitable sound sources, people can find these using only their capacity for directional hearing. Unfortunately, unless very explicit instructions were given, sound beacons currently commercially available (based on modulated noise) led to disappointing results during an evacuation experiment in a traffic tunnel. Only 19% out of 65 subjects were able to find an exit by ear. A signal designed to be more self-explanatory and less hostile-sounding (alternating chime signal and spoken message ``exit here'') increased the success rate to 86%. In a more complex environment-a mock-up of a ship's interior-routes to the exit were marked using multiple beacons. By applying carefully designed time delays between successive beacons, the direction of the route was marked, utilizing the precedence effect. Out of 34 subjects, 71% correctly followed the evacuation route by ear (compared to 24% for a noise signal as used in commercially available beacons). Even when subjects were forced to make a worst-case left-right decision at a T-junction, between two beacons differing only in arrival of the first wave front, 77% made the right decision.

Massive haematuria successfully managed by intravesical ankaferd in a haemodialysis patient complicated with disseminated intravascular coagulation

PubMed Central

Solak, Yalcin; Gaipov, Abduzhappar; Ozbek, Orhan; Hassan, Mustafa Aziz; Yeksan, Mehdi

2012-01-01

Massive haematuria is a life-threatening condition, demanding immediate management of bleeding. The mortality is very high in the case of delayed management of bleeding, especially in elderly patients with concomitant comorbidity. The treatment options of haematuria are wide, and depend on underlying conditions. However, therapeutic choices are limited in the presence of massive and intractable haematuria caused by disseminated intravascular coagulation (DIC). Ankaferd blood stopper (ABS) is a novel, commercially available, haemostatic agent, which has been approved by the Ministry of Health for local use in Turkey. Here, for the first time in the literature, we report a case of diffuse intravesical bleeding stopped by intravesical use of ABS in a 72-year-old man, haemodialysis patient complicated with sepsis and DIC. PMID:23266773

Approaches to reducing photon dose calculation errors near metal implants

DOE Office of Scientific and Technical Information (OSTI.GOV)

Huang, Jessie Y.; Followill, David S.; Howell, Reb

Purpose: Dose calculation errors near metal implants are caused by limitations of the dose calculation algorithm in modeling tissue/metal interface effects as well as density assignment errors caused by imaging artifacts. The purpose of this study was to investigate two strategies for reducing dose calculation errors near metal implants: implementation of metal-based energy deposition kernels in the convolution/superposition (C/S) dose calculation method and use of metal artifact reduction methods for computed tomography (CT) imaging. Methods: Both error reduction strategies were investigated using a simple geometric slab phantom with a rectangular metal insert (composed of titanium or Cerrobend), as well asmore » two anthropomorphic phantoms (one with spinal hardware and one with dental fillings), designed to mimic relevant clinical scenarios. To assess the dosimetric impact of metal kernels, the authors implemented titanium and silver kernels in a commercial collapsed cone C/S algorithm. To assess the impact of CT metal artifact reduction methods, the authors performed dose calculations using baseline imaging techniques (uncorrected 120 kVp imaging) and three commercial metal artifact reduction methods: Philips Healthcare’s O-MAR, GE Healthcare’s monochromatic gemstone spectral imaging (GSI) using dual-energy CT, and GSI with metal artifact reduction software (MARS) applied. For the simple geometric phantom, radiochromic film was used to measure dose upstream and downstream of metal inserts. For the anthropomorphic phantoms, ion chambers and radiochromic film were used to quantify the benefit of the error reduction strategies. Results: Metal kernels did not universally improve accuracy but rather resulted in better accuracy upstream of metal implants and decreased accuracy directly downstream. For the clinical cases (spinal hardware and dental fillings), metal kernels had very little impact on the dose calculation accuracy (<1.0%). Of the commercial CT artifact reduction methods investigated, the authors found that O-MAR was the most consistent method, resulting in either improved dose calculation accuracy (dental case) or little impact on calculation accuracy (spine case). GSI was unsuccessful at reducing the severe artifacts caused by dental fillings and had very little impact on calculation accuracy. GSI with MARS on the other hand gave mixed results, sometimes introducing metal distortion and increasing calculation errors (titanium rectangular implant and titanium spinal hardware) but other times very successfully reducing artifacts (Cerrobend rectangular implant and dental fillings). Conclusions: Though successful at improving dose calculation accuracy upstream of metal implants, metal kernels were not found to substantially improve accuracy for clinical cases. Of the commercial artifact reduction methods investigated, O-MAR was found to be the most consistent candidate for all-purpose CT simulation imaging. The MARS algorithm for GSI should be used with caution for titanium implants, larger implants, and implants located near heterogeneities as it can distort the size and shape of implants and increase calculation errors.« less

Turning Regenerative Medicine Breakthrough Ideas and Innovations into Commercial Products.

PubMed

Bayon, Yves; Vertès, Alain A; Ronfard, Vincent; Culme-Seymour, Emily; Mason, Chris; Stroemer, Paul; Najimi, Mustapha; Sokal, Etienne; Wilson, Clayton; Barone, Joe; Aras, Rahul; Chiesi, Andrea

2015-12-01

The TERMIS-Europe (EU) Industry committee intended to address the two main critical issues in the clinical/commercial translation of Advanced Therapeutic Medicine Products (ATMP): (1) entrepreneurial exploitation of breakthrough ideas and innovations, and (2) regulatory market approval. Since January 2012, more than 12,000 publications related to regenerative medicine and tissue engineering have been accepted for publications, reflecting the intense academic research activity in this field. The TERMIS-EU 2014 Industry Symposium provided a reflection on the management of innovation and technological breakthroughs in biotechnology first proposed to contextualize the key development milestones and constraints of allocation of financial resources, in the development life-cycle of radical innovation projects. This was illustrated with the biofuels story, sharing similarities with regenerative medicine. The transition was then ensured by an overview of the key identified challenges facing the commercialization of cell therapy products as ATMP examples. Real cases and testimonies were then provided by a palette of medical technologies and regenerative medicine companies from their commercial development of cell and gene therapy products. Although the commercial development of ATMP is still at the proof-of-concept stage due to technology risks, changing policies, changing markets, and management changes, the sector is highly dynamic with a number of explored therapeutic approaches, developed by using a large diversity of business models, both proposed by the experience, pitfalls, and successes of regenerative medicine pioneers, and adapted to the constraint resource allocation and environment in radical innovation projects.

Early Childhood Education and Adult-Oriented Advertising Discourse

ERIC Educational Resources Information Center

Constandinidou-Semoglou, Ourania

2007-01-01

Much of the advertising content children see is adult-oriented. However, research has focused on commercials designed for child audiences. Also, whether advertising is commercially successful or not, it constitutes a "form of acculturation". However, research is mainly focused on perception of the commercial dimension of advertising, and…

Technology Transfer Report

NASA Technical Reports Server (NTRS)

2000-01-01

Since its inception, Goddard has pursued a commitment to technology transfer and commercialization. For every space technology developed, Goddard strives to identify secondary applications. Goddard then provides the technologies, as well as NASA expertise and facilities, to U.S. companies, universities, and government agencies. These efforts are based in Goddard's Technology Commercialization Office. This report presents new technologies, commercialization success stories, and other Technology Commercialization Office activities in 1999.

NASA's Earth Observations Commercialization Applications Program: A model for government promotion of commercial space opportunities

NASA Technical Reports Server (NTRS)

Macauley, Molly K.

1995-01-01

The role of government in promoting space commerce is a topic of discussion in every spacefaring nation. This article describes a new approach to government intervention which, based on its five-year track record, appears to have met with success. The approach, developed in NASA's Earth Observations Commercialization Application Program (EOCAP), offer several lessons for effective government sponsorship of commercial space development in general and of commercial remote sensing in particular.

Thermal modeling of secondary lithium batteries for electric vehicle/hybrid electric vehicle applications

NASA Astrophysics Data System (ADS)

Al-Hallaj, Said; Selman, J. R.

A major obstacle to the development of commercially successful electric vehicles (EV) or hybrid electric vehicles (HEV) is the lack of a suitably sized battery. Lithium ion batteries are viewed as the solution if only they could be "scaled-up safely", i.e. if thermal management problems could be overcome so the batteries could be designed and manufactured in much larger sizes than the commercially available near-2-Ah cells. Here, we review a novel thermal management system using phase-change material (PCM). A prototype of this PCM-based system is presently being manufactured. A PCM-based system has never been tested before with lithium-ion (Li-ion) batteries and battery packs, although its mode of operation is exceptionally well suited for the cell chemistry of the most common commercially available Li-ion batteries. The thermal management system described here is intended specifically for EV/HEV applications. It has a high potential for providing effective thermal management without introducing moving components. Thereby, the performance of EV/HEV batteries may be improved without complicating the system design and incurring major additional cost, as is the case with "active" cooling systems requiring air or liquid circulation.

Comparison of two real-time PCR assays for the detection of malaria parasites from hemolytic blood samples - Short communication.

PubMed

Hagen, Ralf Matthias; Hinz, Rebecca; Tannich, Egbert; Frickmann, Hagen

2015-06-01

We compared the performance of an in-house and a commercial malaria polymerase chain reaction (PCR) assay using freeze-thawed hemolytic blood samples. A total of 116 freeze-thawed ethylenediamine tetraacetic acid (EDTA) blood samples of patients with suspicion of malaria were analyzed by an in-house as well as by a commercially available real-time PCR. Concordant malaria negative PCR results were reported for 39 samples and malaria-positive PCR results for 67 samples. The in-house assay further detected one case of Plasmodium falciparum infection, which was negative in the commercial assay as well as five cases of P. falciparum malaria and three cases of Plasmodium vivax malaria, which showed sample inhibition in the commercial assay. The commercial malaria assay was positive in spite of a negative in-house PCR result in one case. In all concordant results, cycle threshold values of P. falciparum-positive samples were lower in the commercial PCR than in the in-house assay. Although Ct values of the commercial PCR kit suggest higher sensitivity in case of concordant results, it is prone to inhibition if it is applied to hemolytic freeze-thawed blood samples. The number of misidentifications was, however, identical for both real-time PCR assays.

University of Utah, Energy Commercialization Center

DOE Office of Scientific and Technical Information (OSTI.GOV)

Thompson, James

During the Energy Commercialization Center’s (ECC) three years in operation, the only thing constant was change. The world of commercialization and cleantech evolved significantly during the time the ECC was formed and operating, including: the availability of cleantech funding lessoned, the growth of incubators and accelerators skyrocketed, the State of Utah created an office dedicated to energy development, the University of Utah was both praised and criticized for its success in commercialization, and the Federal government temporarily shut down. During the three-year grant there were three principle investigators on the grant, as well as three directors for the University’s Commercializationmore » Office. Change can be hard for an organization,but as we instruct the companies we support, “Fail fast and fail often, because it is the fastest path to success.” Although there were some unanticipated challenges along the way, the local ecosystem is stronger because of the ECC’s efforts. Perhaps the greatest lesson learned was the importance of aligned incentives between key stakeholders in the commercialization process and the need for resources at the company and individual entrepreneur levels. The universities have systems and incentives to commercialize technologies, but creating value and companies generally rest with the individuals and entrepreneurs. Unfortunately the ECC was unable to create a viable mechanism to transfer the commercialization process that successfully aligned incentives and achieve a more effective ecosystem within the Rocky Mountain West. However, the ECC was successful in adding value to the individual ecosystems, and connecting national resources to regional and local needs. Regarding the ECC’s effectiveness in developing a cleantech commercialization ecosystem, initial inroads and relationships were established with key stakeholders. However, incentives, perceived or real competition, differences in commercialization processes, and culture all played a role in inhibiting the development and distribution of a regional ecosystem and commercialization process. Had the University and the ECC been able to develop a software platform, some of these challenges may have been overcome, but without the final development and release of the Western Innovation Network, the ECC realistically could not scale and distribute a commercialization platform. Further, cleantech startups need to engage in a more intensive customer validation process, and establish strong community connections if they are to succeed in commercializing their products. The university system incentivizes research and access to research funding and risk capital is competitive, so by nature collaboration on commercialization was difficult. Each of the local ecosystems within the Rocky Mountain West was unique. Utah did not, and does not, have a system outside of the universities to support entrepreneurs and cleantech commercialization. Through the ECC’s efforts developing a regional ecosystem, it became clear that successful ecosystems had a community and associated mechanisms that supported local entrepreneurs and startups. Most importantly the ECC aided in the creation of Utah’s cleantech ecosystem, one that supports entrepreneurs and startup companies that need help and support in their efforts to commercialize clean technologies. The absence of support for clean tech from state government and local organizations was a significant impediment to cleantech commercialization. To overcome this challenge, the ECC has formed Sustainable Startups. Sustainable Startups is a new non-profit organization designed to build a culture and community in Utah that supports and understands the importance of cleantech and sustainable development. While the ECC generated mixed success in building a regional commercialization ecosystem for cleantech, the organization did provide tremendous benefit to startups and the broader public. Over 60 companies were given direct business development support by the ECC, many of whom then generated direct economic development impacts. In addition, the ECC served an important role as community convener, educator and relationship builder through hosting numerous public and private events including: Energize 2013; Millennial Train whistle stop; business plan competition supporter; Clean Tech Open Accelerator organizer; Sustainable Startups Series developer, and much more. While the ECC did not fully apply, develop, and transmit the University of Utah’s TCO commercialization model to cleantech, it nevertheless assisted numerous inventors, entrepreneurs and institutions in furthering the growth of clean energy and energy efficiency technologies. The TCO’s commercialization model was not applied to regional clean tech initiatives for several main reasons. First, flaws with the commercialization model were realized after the ECC’s formation. Second, leadership changes within the TCO and ECC hampered early organizational development and implementation initiatives. Third, misaligned incentives between the ECC, regional universities, institutions, and the State of Utah resulted in a lack of collaboration and knowledge transfer regarding commercialization. In principle, everyone was aligned and willing to collaborate, but reality was much different and challenging.« less

Pathways to Commercial Success: Technologies and Products Supported by the Fuel Cell Technologies Office - 2014

DOE Office of Scientific and Technical Information (OSTI.GOV)

None, None

This FY 2014 report updates the results of an effort to identify and characterize commercial and near-commercial (emerging) technologies and products that benefited from the support of the Fuel Cell Technologies Office and its predecessor programs within DOE's Office of Energy Efficiency and Renewable Energy.

Pathways to Commercial Success. Technologies and Products Supported by the Fuel Cell Technologies Program - 2012

DOE Office of Scientific and Technical Information (OSTI.GOV)

none,

This FY 2012 report updates the results of an effort to identify and characterize commercial and near-commercial (emerging) technologies and products that benefited from the support of the Fuel Cell Technologies Program and its predecessor programs within DOE's Office of Energy Efficiency and Renewable Energy.

Pathways to Commercial Success. Technologies and Products Supported by the Fuel Cell Technologies Program

DOE Office of Scientific and Technical Information (OSTI.GOV)

none,

This FY 2011 report updates the results of an effort to identify and characterize commercial and near-commercial (emerging) technologies and products that benefited from the support of the Fuel Cell Technologies Program and its predecessor programs within DOE's Office of Energy Efficiency and Renewable Energy.

Pathways to Commercial Success: Technologies and Products Supported by the Fuel Cell Technologies Office - 2013

DOE Office of Scientific and Technical Information (OSTI.GOV)

none,

This FY 2013 report updates the results of an effort to identify and characterize commercial and near-commercial (emerging) technologies and products that benefited from the support of the Fuel Cell Technologies Office and its predecessor programs within DOE's Office of Energy Efficiency and Renewable Energy.

The commercial campground industry in New Hampshire. A report on a 1971 campground census.

Treesearch

Wilbur F. LaPage; Paula L. Cormier; Steven C. Maurice; Steven C. Maurice

1972-01-01

The findings of a 1971 census of commercial camping enterprises in New Hampshire, including the growth of commercial camping enterprises during the period 1960-71, the average per-site costs and returns for operating a campground in 1970, and the characteristics of 78 successful and 89 unsuccessful camping enterprises.

Epidemiological investigations of the introduction of porcine reproductive and respiratory syndrome virus in Chile, 2013-2015

PubMed Central

Neira, Víctor; Mena, Juan; Culhane, Marie; Apel, Maria Ignacia; Max, Vanessa; Perez, Patricio; Moreno, Valentina; Mathieu, Christian; Johow, Magdalena; Badia, Catalina; Torremorell, Montserrat; Medina, Rafael; Ortega, Rene

2017-01-01

Porcine reproductive and respiratory syndrome (PRRS) is endemic in most pork producing countries. In Chile, eradication of PRRS virus (PRRSV) was successfully achieved in 2009 as a result of the combined efforts of producers and the animal health authorities. In October 2013, after several years without detecting PRRSV under surveillance activities, suspected cases were confirmed on a commercial swine farm. Here, we describe the PRRS epidemic in Chile between October 2013 and April 2015, and we studied the origins and spread of PRRSV throughout the country using official surveillance data and Bayesian phylogenetic analysis. Our results indicate that the outbreaks were caused by a PRRSV closely related to viruses present in swine farms in North America, and different from the strain that circulated in the country before 2009. Using divergence time estimation analysis, we found that the 2013–2015 PRRSV may have been circulating in Chile for at least one month before the first detection. A single strain of PRRSV spread into a limited number of commercial and backyard swine farms. New infections in commercial systems have not been reported since October 2014, and eradication is underway by clearing the disease from the few commercial and backyard farms that remain positive. This is one of the few documented experiences of PRRSV introduction into a disease-free country. PMID:28742879

Epidemiological investigations of the introduction of porcine reproductive and respiratory syndrome virus in Chile, 2013-2015.

PubMed

Neira, Víctor; Brito, Barbara; Mena, Juan; Culhane, Marie; Apel, Maria Ignacia; Max, Vanessa; Perez, Patricio; Moreno, Valentina; Mathieu, Christian; Johow, Magdalena; Badia, Catalina; Torremorell, Montserrat; Medina, Rafael; Ortega, Rene

2017-01-01

Porcine reproductive and respiratory syndrome (PRRS) is endemic in most pork producing countries. In Chile, eradication of PRRS virus (PRRSV) was successfully achieved in 2009 as a result of the combined efforts of producers and the animal health authorities. In October 2013, after several years without detecting PRRSV under surveillance activities, suspected cases were confirmed on a commercial swine farm. Here, we describe the PRRS epidemic in Chile between October 2013 and April 2015, and we studied the origins and spread of PRRSV throughout the country using official surveillance data and Bayesian phylogenetic analysis. Our results indicate that the outbreaks were caused by a PRRSV closely related to viruses present in swine farms in North America, and different from the strain that circulated in the country before 2009. Using divergence time estimation analysis, we found that the 2013-2015 PRRSV may have been circulating in Chile for at least one month before the first detection. A single strain of PRRSV spread into a limited number of commercial and backyard swine farms. New infections in commercial systems have not been reported since October 2014, and eradication is underway by clearing the disease from the few commercial and backyard farms that remain positive. This is one of the few documented experiences of PRRSV introduction into a disease-free country.

Balancing innovation with commercialization in NASA's Science Mission Directorate SBIR Program

NASA Astrophysics Data System (ADS)

Terrile, R. J.; Jackson, B. L.

The NASA Science Mission Directorate (SMD) administers a portion of the Small Business Innovative Research (SBIR) Program. One of the challenges of administrating this program is to balance the need to foster innovation in small businesses and the need to demonstrate commercialization by infusion into NASA. Because of the often risky nature of innovation, SBIR programs will tend to drift into a status that rewards proposals that promise to deliver a product that is exactly what was specified in the call. This often will satisfy the metric of providing a clear demonstration of infusion and thus also providing a publishable success story. However, another goal of the SBIR program is to foster innovation as a national asset. Even though data from commercially successful SMD SBIR tasks indicate a higher value for less innovative efforts, there are programmatic and national reasons to balance the program toward risking a portion of the portfolio on higher innovation tasks. Establishing this balance is made difficult because there is a reward metric for successful infusion and commercialization, but none for successful innovation. In general, the ultimate infusion and commercialization of innovative solutions has a lower probability than implementation of established ideas, but they can also have a much higher return on investment. If innovative ideas are valued and solicited in the SBIR program, then NASA technology requirements need to be specified in a way that defines the problem and possible solution, but will also allow for different approaches and unconventional methods. It may also be necessary to establish a guideline to risk a percentage of awards on these innovations.

NASA commercial technology. Agenda for change

NASA Technical Reports Server (NTRS)

1994-01-01

The essence of NASA's new way of doing business to support the agency's commercial technology mission objectives is described. A summary description of the various changes needed to successfully perform this mission is provided.

Sustainable Technologies: Finding Success the Second Time Around

DOE Office of Scientific and Technical Information (OSTI.GOV)

Walkowicz, Kevin

2016-03-03

Presentation provides background on how to identify and quantify improvements for advanced vehicle technology and commercial fleet operations. It gives examples of next generation technology improvements that have been implemented within commercial fleets.

Maritime security report. November 2000 [Commercial maritime drug smuggling

DOT National Transportation Integrated Search

2000-11-01

Port and security programs being implemented in Colombia's port facilities, maritime jurisdictions, and the marine intermodal shipping cycle are producing successful results against commercial maritime drug smuggling. This security reports examines t...

Defined PEG smears as an alternative approach to enhance the search for crystallization conditions and crystal-quality improvement in reduced screens

PubMed Central

Chaikuad, Apirat; Knapp, Stefan; von Delft, Frank

2015-01-01

The quest for an optimal limited set of effective crystallization conditions remains a challenge in macromolecular crystallography, an issue that is complicated by the large number of chemicals which have been deemed to be suitable for promoting crystal growth. The lack of rational approaches towards the selection of successful chemical space and representative combinations has led to significant overlapping conditions, which are currently present in a multitude of commercially available crystallization screens. Here, an alternative approach to the sampling of widely used PEG precipitants is suggested through the use of PEG smears, which are mixtures of different PEGs with a requirement of either neutral or cooperatively positive effects of each component on crystal growth. Four newly defined smears were classified by molecular-weight groups and enabled the preservation of specific properties related to different polymer sizes. These smears not only allowed a wide coverage of properties of these polymers, but also reduced PEG variables, enabling greater sampling of other parameters such as buffers and additives. The efficiency of the smear-based screens was evaluated on more than 220 diverse recombinant human proteins, which overall revealed a good initial crystallization success rate of nearly 50%. In addition, in several cases successful crystallizations were only obtained using PEG smears, while various commercial screens failed to yield crystals. The defined smears therefore offer an alternative approach towards PEG sampling, which will benefit the design of crystallization screens sampling a wide chemical space of this key precipitant. PMID:26249344

Defined PEG smears as an alternative approach to enhance the search for crystallization conditions and crystal-quality improvement in reduced screens.

PubMed

Chaikuad, Apirat; Knapp, Stefan; von Delft, Frank

2015-08-01

The quest for an optimal limited set of effective crystallization conditions remains a challenge in macromolecular crystallography, an issue that is complicated by the large number of chemicals which have been deemed to be suitable for promoting crystal growth. The lack of rational approaches towards the selection of successful chemical space and representative combinations has led to significant overlapping conditions, which are currently present in a multitude of commercially available crystallization screens. Here, an alternative approach to the sampling of widely used PEG precipitants is suggested through the use of PEG smears, which are mixtures of different PEGs with a requirement of either neutral or cooperatively positive effects of each component on crystal growth. Four newly defined smears were classified by molecular-weight groups and enabled the preservation of specific properties related to different polymer sizes. These smears not only allowed a wide coverage of properties of these polymers, but also reduced PEG variables, enabling greater sampling of other parameters such as buffers and additives. The efficiency of the smear-based screens was evaluated on more than 220 diverse recombinant human proteins, which overall revealed a good initial crystallization success rate of nearly 50%. In addition, in several cases successful crystallizations were only obtained using PEG smears, while various commercial screens failed to yield crystals. The defined smears therefore offer an alternative approach towards PEG sampling, which will benefit the design of crystallization screens sampling a wide chemical space of this key precipitant.

Spinoff 1998

NASA Technical Reports Server (NTRS)

1998-01-01

In 1958, a Congressional Mandate directed the National Aeronautics and Space Agency to ensure for the widest possible dissemination of its research and development results. Thus, the Scientific and Technical Information (STI) Program was born. While this program addressed mostly the timely dissemination of information to NASA, NASA contractors, other government agencies, and the public, technologies were identified that were clearly transferable and applicable to industry for additional use in the development of commercial products and services. Such considerations spun off the Technology Utilization Program. The very successful program went through several name changes and is today called the NASA Commercial Technology Program. The changes that have occurred over time are not only name changes, but program changes that have dramatically altered the philosophy, mission, and goal of the program. It has been identified that a more intense and proactive outreach effort within the program is necessary in order to make the newest and latest technologies available to industry now-at the time the technology is actually developed. The NASA Commercial Technology Network (NCTN), its interaction with industry at all levels through a large network of organizations and offices, is contributing to the success of small, medium, and large U.S. businesses to remain globally competitive. At the same time, new products and services derived from the transfer and application of NASA technology benefit everyone. This publication includes the following: Aerospace research and development - NASA headquarters and centers. Technology transfer and commercialization. Commercial benefits - spinoffs.NASA success and education. NASA commercial technology network.

An analysis of successful commercialization of federally funded R&D energy technologies

NASA Astrophysics Data System (ADS)

Asuquo, Gibson Esang

Several studies indicate that commercialization of federally funded R&D technologies to private sector remains low. In an extension of research demonstrating relative effectiveness of various technology-transfer mechanisms used by the Department of Energy (DOE) in transferring federally funded R&D technologies, this study quantitatively analyzed 52 Industrial Technology Program (ITP) funded R&D technologies, from 1993 through 2006, to understand commercialization success of DOE's funded R&D technologies, based on the correlative significance between independent variables (R&D durations and levels of funding) and dependent variable (technology commercialization output). No statistically significant linear relationship was found between the studied variables. The R2 (the coefficient of multiple determination) value indicates that only three percent (0.03) of the change in the output of commercialized technologies can be explained by the change in the two independent variables. The results of this study have led to an important conclusion that the research, development, and deployment (RD&D) of federally funded energy technologies is complex and a non-linear process. The problem requires a consideration of other factors and a research design that can accommodate the complexity involved. However, as determined by this study, the ITP technology commercialization output (success rate) of 22% is nearly two times as high as the 14% Booz-Allen estimate for the rest of U.S. industry. A quantitative research (such as this study) that attempts to understand the relative significance of correlational relationship between R&D variables appears to offer insufficient explanations as to why the federal government is not getting high technology commercialization output from its dollar investments in R&D. Some qualitative research approaches could move this important research to the next level in the future. Further research in this area should focus on causal effects between R&D variables. The study should attempt to identify the effect that could be caused by an early involvement of angel investors, venture capitalists, and end-users of technologies during RD&D. Successful commercialization of energy technologies requires targeting the most promising innovations that may be jointly supported by public and private sector. A few suggestions on how to improve commercialization of federally funded R&D are outlined in Section 10.3 of this study.

78 FR 300 - Change in Bank Control Notices; Acquisitions of Shares of a Bank or Bank Holding Company

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-03

... C. Davis Succession Trust; the Ricky J. Davis Succession Trust; and the Kenneth R. Davis Succession... Steven C. Davis Succession Trust, the Ricky J. Davis Succession Trust, and the Kenneth R. Davis Succession Trust, to become a part of the group acting in concert to acquire control of First Commercial...

Seasat-A ASVT: Commercial demonstration experiments. Results analysis methodology for the Seasat-A case studies

NASA Technical Reports Server (NTRS)

1979-01-01

The SEASAT-A commercial demonstration program ASVT is described. The program consists of a set of experiments involving the evaluation of a real time data distributions system, the SEASAT-A user data distribution system, that provides the capability for near real time dissemination of ocean conditions and weather data products from the U.S. Navy Fleet Numerical Weather Central to a selected set of commercial and industrial users and case studies, performed by commercial and industrial users, using the data gathered by SEASAT-A during its operational life. The impact of the SEASAT-A data on business operations is evaluated by the commercial and industrial users. The approach followed in the performance of the case studies, and the methodology used in the analysis and integration of the case study results to estimate the actual and potential economic benefits of improved ocean condition and weather forecast data are described.

Qualitative Analysis of Commercial Social Network Profiles

NASA Astrophysics Data System (ADS)

Melendez, Lester; Wolfson, Ouri; Adjouadi, Malek; Rishe, Naphtali

Social-networking sites have become an integral part of many users' daily internet routine. Commercial enterprises have been quick to recognize this and are subsequently creating profiles for many of their products and services. Commercial enterprises use social network profiles to target and interact with potential customers as well as to provide a gateway for users of the product or service to interact with each other. Many commercial enterprises use the statistics from their product or service's social network profile to tout the popularity and success of the product or service being showcased. They will use statistics such as number of friends, number of daily visits, number of interactions, and other similar measurements to quantify their claims. These statistics are often not a clear indication of the true popularity and success of the product. In this chapter the term product is used to refer to any tangible or intangible product, service, celebrity, personality, film, book, or other entity produced by a commercial enterprise.

NASA technology applications team: Applications of aerospace technology

NASA Technical Reports Server (NTRS)

1989-01-01

Two critical aspects of the Applications Engineering Program were especially successful: commercializing products of Application Projects; and leveraging NASA funds for projects by developing cofunding from industry and other agencies. Results are presented in the following areas: the excimer laser was commercialized for clearing plaque in the arteries of patients with coronary artery disease; the ultrasound burn depth analysis technology is to be licensed and commercialized; a phased commercialization plan was submitted to NASA for the intracranial pressure monitor; the Flexible Agricultural Robotics Manipulator System (FARMS) is making progress in the development of sensors and a customized end effector for a roboticized greenhouse operation; a dual robot are controller was improved; a multisensor urodynamic pressure catherer was successful in clinical tests; commercial applications were examined for diamond like carbon coatings; further work was done on the multichannel flow cytometer; progress on the liquid airpack for fire fighters; a wind energy conversion device was tested in a low speed wind tunnel; and the Space Shuttle Thermal Protection System was reviewed.

Efficacy of Candida sake CPA-1 formulation for controlling Penicillium expansum decay on pome fruit from different Mediterranean regions.

PubMed

Torres, R; Teixidó, N; Viñas, I; Mari, M; Casalini, L; Giraud, M; Usall, J

2006-11-01

The effectiveness of a formulated product of the yeast Candida sake CPA-1 for controlling postharvest diseases on pome fruits was demonstrated in laboratory, semicommercial, and commercial trials carried out in the major pome fruit producing region of the European Union. First, one wettable powder and seven liquid formulations were tested in laboratory trials that involved two varieties of apples and two varieties of pears. In all cases, an efficacy similar to that of fresh cells was demonstrated in the control of artificial Penicillium expansum infection. After these trials, the formulated product chosen for semicommercial and commercial trials was LF1, a liquid formulation that is particularly suitable for commercial applications. In semicommercial trials, LF1 showed a performance similar to fresh cells in most trials, and the population dynamics of both fresh and formulated cells were quite stable throughout the storage period. This indicates the high viability of C. sake CPA-1 in this formulation and the absence of adverse effects during the formulation of the product, which may significantly affect both its ability to grow on fruit and its antagonistic activity. We evaluated the control of natural infection after applying the formulated product in a commercial drencher in different packinghouses. A significant reduction in the incidence of diseases was observed with a recommended dose of around 10(7) CFU/ml when natural infections were greater than 1%. In general, large quantities of yeast were observed on the surface of unwounded fruits of different pome fruit cultivars. Moreover, populations of this biocontrol agent increased rapidly on fruit surfaces and remained quite stable for a long time under commercial storage conditions. Commercial practices used in packinghouses were therefore successfully applied for this formulated product.

Spinoff 2002: Fortieth Anniversary Technology Utilization Program

NASA Technical Reports Server (NTRS)

2002-01-01

Since its inception 40 years ago, NASA's Technology Transfer Program has led the way for our nation to benefit from cutting-edge aerospace technologies. In addition to contributing to U.S. economic growth, these technologies are improving the quality of life on Earth while finding new ways to protect and preserve it. NASA's research and development efforts have advanced areas in medicine, communications, manufacturing, computer technology, and homeland security. These breakthroughs, translated into commercial products, are enhancing the lives of Americans everywhere. When a congressional mandate led NASA to develop the Scientific and Technical Information (STI) Program, the Agency began a wide dissemination of its research and development results. In doing so, NASA recognized that many of its technologies were transferable to industry for the development of commercial products. As a result, the Technology Utilization Program was born in 1962. The successful program went through several changes over the years, as its philosophy, mission, and goals adapted into the Technology Transfer Program we know today. The program strives to make the latest technologies available to industry as soon as they are developed. Each year, NASA's Spinoff publication showcases new products and services resulting from commercial partnerships between NASA and private industry. In the 2002 issue, the NASA field centers reflect upon the growth that has made these innovations available to the public. The Research and Development section examines past achievements, current successes, and future goals for each of the ten NASA centers. The Commercial Benefits section proudly highlights 51 new spinoff products, including a heart pump for patients needing a heart transplant, as well as an air purifier that destroys anthrax spores. The Technology Transfer and Outreach section describes the outreach achievements and educational successes made possible through the NASA Commercial Technology Network. Each section of Spinoff 2002 provides compelling evidence of the Technology Transfer Program's success and value. With commercial products and successes spanning from work on the Apollo missions to the International Space Station, the 40th anniversary of the Technology Transfer Program invites us to celebrate our history while planning the future.

Results from prototypes of environmental and health alarm devices based on gaseous detectors operating in air in counting mode

NASA Astrophysics Data System (ADS)

Charpak, G.; Benaben, P.; Breuil, P.; Martinengo, P.; Nappi, E.; Peskov, V.

2011-02-01

We have developed and successfully tested two prototypes of detectors of dangerous gases based on wire-type counters operating in air in avalanche mode: one is for radon (Rn) detection whereas the other one is for the detection of gases with an ionization potential less than the air components. Due to the operation in pulse counting mode these prototypes have sensitivities comparable to (in the case of the Rn detector) or much higher than (in the case of the detector for low ionization gases) the best commercial devices currently available on the market. We believe that due to their high sensitivity, simplicity and low cost such new detectors will find massive applications. One of them, discussed in this paper, could be the on-line monitoring of Rn for the prediction of earthquakes.

PRINCIPLES OF AFFINITY-BASED BIOSENSORS

EPA Science Inventory

Despite the amount of resources that have been invested by national and international academic, government, and commercial sectors to develop affinity-based biosensor products, little obvious success has been realized through commercialization of these devices for specific applic...

Photonics technology and university-driven business co-creation

NASA Astrophysics Data System (ADS)

Erland Østergaard, J.; Tanev, S.; Bue Andersen, T.; Bozhevolnyi, S. I.

2012-03-01

TEK-Momentum is the Business Innovation and Technology Department in the Faculty of Engineering at the University of Southern Denmark in Odense. Since its establishment in 2010 the Department has adopted an exploratory technology transfer, open business development and co-creation strategy that goes beyond traditional technology transfer activities. This is an emerging strategy that has been shaped for the last 5 years even before the formal establishment of TEKMomentum. It emerged out of multiple dialog-based interactions with small- and medium-sized companies by focusing on matching real life problems with potential problem solvers. The main priority of such strategy is maximizing the value of the potential contributions from the multiple stakeholders and not on the technology development issues per se. In this paper we will present an overview of TEK-Momentum's approach by using as case studies two recent successful projects. The first one focuses on the commercialization of an LED illumination system. The second one focuses on the commercialization of an optical ring resonator-based temperature sensor.

The availability of Landsat data: Past, present, and future

USGS Publications Warehouse

Draeger, W.C.; Holm, T.M.; Lauer, D.T.; Thompson, R.J.

1997-01-01

It has long been recognized that the success of the Landsat program would depend on an effective distribution of its data to a wide variety of users, worldwide, in a timely manner. Since 1972, nearly $250 million worth of data have been distributed by a network of ground stations around the world. The policies of the U.S. Government affecting the distribution, availability, and pricing of Landsat data have been controversial, and have been strongly affected by the attempts to commercialize the program. At the present time, data are being distributed in the U.S. by either government or commercial entities, depending on the date of acquisition of the data in question and whether or not the customer is affiliated with the Federal Government. Although the future distribution of Landsat data is currently under discussion, it seems likely that data distribution initially will be the responsibility of NOAA. In any case, the long-term archive and distribution of all Landsat data will be the responsibility of the Department of Interior's U.S. Geological Survey.

The state of genetically modified crop regulation in Canada

PubMed Central

Smyth, Stuart J

2014-01-01

Genetically modified (GM) crops were first commercialized in Canada in 1995 and the 2014 crop represents the 20th year of successful production. Prior to the first commercialization of GM crops, Canada reviewed its existing science-based regulatory framework and adapted the existing framework to allow for risk assessments on the new technology to be undertaken in a timely and efficient manner. The result has been the rapid and widespread adoption of GM varieties of canola, corn and soybeans. The first decade of GM crop production precipitated 2 landmark legal cases relating to patent infringement and economic liability, while the second decade witnessed increased political efforts to have GM crops labeled in Canada as well as significant challenges from the low level comingling of GM crops with non-GM commodities. This article reviews the 20 y of GM crop production in Canada from a social science perspective that includes intellectual property, consumer acceptance and low level presence. PMID:25437238

Automated, Parametric Geometry Modeling and Grid Generation for Turbomachinery Applications

NASA Technical Reports Server (NTRS)

Harrand, Vincent J.; Uchitel, Vadim G.; Whitmire, John B.

2000-01-01

The objective of this Phase I project is to develop a highly automated software system for rapid geometry modeling and grid generation for turbomachinery applications. The proposed system features a graphical user interface for interactive control, a direct interface to commercial CAD/PDM systems, support for IGES geometry output, and a scripting capability for obtaining a high level of automation and end-user customization of the tool. The developed system is fully parametric and highly automated, and, therefore, significantly reduces the turnaround time for 3D geometry modeling, grid generation and model setup. This facilitates design environments in which a large number of cases need to be generated, such as for parametric analysis and design optimization of turbomachinery equipment. In Phase I we have successfully demonstrated the feasibility of the approach. The system has been tested on a wide variety of turbomachinery geometries, including several impellers and a multi stage rotor-stator combination. In Phase II, we plan to integrate the developed system with turbomachinery design software and with commercial CAD/PDM software.

Photocatalytic treatment of bioaerosols: impact of the reactor design.

PubMed

Josset, Sébastien; Taranto, Jérôme; Keller, Nicolas; Keller, Valérie; Lett, Marie-Claire

2010-04-01

Comparing the UV-A photocatalytic treatment of bioaerosols contaminated with different airborne microorganisms such as L. pneumophila bacteria, T2 bacteriophage viruses and B. atrophaeus bacterial spores, pointed out a decontamination sensitivity following the bacteria > virus > bacterial spore ranking order, differing from that obtained for liquid-phase or surface UV-A photocatalytic disinfection. First-principles CFD investigation applied to a model annular photoreactor evidenced that larger the microorganism size, higher the hit probability with the photocatalytic surfaces. Applied to a commercial photocatalytic purifier case-study, the CFD calculations showed that the performances of the studied purifier could strongly benefit from rational reactor design engineering. The results obtained highlighted the required necessity to specifically investigate the removal of airborne microorganisms in terms of reactor design, and not to simply transpose the results obtained from studies performed toward chemical pollutants, especially for a successful commercial implementation of air decontamination photoreactors. This illustrated the importance of the aerodynamics in air decontamination, directly resulting from the microorganism morphology.

Information Privacy in the Marketspace: Implications for the Commercial Uses of Anonymity on the Web.

ERIC Educational Resources Information Center

Hoffman, Donna L.; Novak, Thomas P.; Peralta, Marcos A.

1999-01-01

Suggests that the primary barrier to successful commercial development of the Web is lack of consumer trust in the medium. Examines how customer concerns are affecting growth and development of consumeroriented commercial activity on the Web and investigates the implications of these concerns for potential industry response. Suggests that radical…

Market Access Advancements and Challenges in “Drug-Companion Diagnostic Test” Co-Development in Europe

PubMed Central

Akhmetov, Ildar; Ramaswamy, Rakshambikai; Akhmetov, Illias; Thimmaraju, Phani Kishore

2015-01-01

The pharma ecosphere is witnessing a measured transformation from the one-size-fits-all or blockbuster model of drugs to more informed and tailored personalized treatments that facilitate higher safety and efficacy for a relevant sub-population. However, with several breakthroughs still in a nascent stage, market access becomes a crucial factor for commercial success, especially when it comes to co-creating value for pertinent stakeholders. This article highlights diverse issues from stakeholder perspectives in Europe, specifically the ones which require immediate resolution. Furthermore, the article also discusses case studies articulating potential solutions for the issues discussed. PMID:26075972

Neat methanol fuel cell power plant

NASA Astrophysics Data System (ADS)

Abens, S.; Farooque, M.

1985-12-01

Attention is given to a fuel cell development effort which has been directed, by ease-of-supply, low weight, and low volume criteria toward the use of undiluted methanol. Partial oxidation and internal water recovery concepts are incorporated, allowing the onboard dilution of methanol fuel through mixing with exhaust-recovered water. This scheme is successfully demonstrated for the case of a 3 kW unit employing commercial cross flow heat exchangers, as well as for a 5 kW reformer flue exhaust water recovery design with U.S. Air force baseload stationary applications. The USAF powerplant has an overall thermal efficiency of 32 percent at rated load.

Commercialization of a DOE Laboratory

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stephenson, Barry A.

2008-01-15

On April 1, 1998, Materials and Chemistry Laboratory, Inc. (MCLinc) began business as an employee-owned, commercial, applied research laboratory offering services to both government and commercial clients. The laboratory had previously been a support laboratory to DoE's gaseous diffusion plant in Oak Ridge (K-25). When uranium enrichment was halted at the site, the laboratory was expanded to as an environmental demonstration center and served from 1992 until 1997 as a DOE Environmental User Facility. In 1997, after the laboratory was declared surplus, it was made available to the employee group who operated the laboratory for DOE as a government-owned, contractor-operatedmore » facility. This paper describes briefly the process of establishing the business. Attributes that contributed to the success of MCLinc are described. Some attention is given to lessons learned and to changes that could facilitate future attempts to make similar transitions. Lessons learnt: as with any business venture, operation over time has revealed that some actions taken by the laboratory founders have contributed to its successful operation while others were not so successful. Observations are offered in hopes that lessons learned may suggest actions that will facilitate future attempts to make similar transitions. First, the decision to vest significant ownership of the business in the core group of professionals operating the business is key to its success. Employee-owners of the laboratory have consistently provided a high level of service to its customers while conducting business in a cost-efficient manner. Secondly, an early decision to provide business support services in-house rather than purchasing them from support contractors on site have proven cost-effective. Laboratory employees do multiple tasks and perform overhead tasks in addition to their chargeable technical responsibilities. Thirdly, assessment of technical capabilities in view of market needs and a decision to offer these capabilities as a niche market play to success. The niche was further defined by preservation of the ability to handle samples contaminated with radiological materials and those with classification concerns. These decisions enabled early marketing plans to be built on existing clientele and provided an identifiable group to which future marketing could be expanded. Finally, recruitment of key players with commercial laboratory experience proved to be a key factor for success. This experience base was valuable in avoiding early mistakes in the laboratory startup phase and provided some connection to a commercial client base. As the business has grown, professionals with commercial laboratory experience have been recruited and offered ownership in the business as an incentive for joining the group. If the process were to be repeated, early involvement of an individual with commercial sales experience would be helpful in broadening the base of commercial clients. An increased emphasis on research funding such as funding received from Small Business Innovative Research (SBIR) sources would be used to form a portion of the economic base for the business. More partnerships with businesses whose services compliment those of the laboratory would expand available client base. More flexible staffing arrangements would be negotiated early on as a cost-control measure. In conclusion, the re-industrialization concept can be successful. Candidates for re-industrialization must be chosen by matching services to be offered to market needs. Implementation is best accomplished by entrepreneurs who personally profit from a successful operation of the business.« less

Evolutionary Aspects for Technology Policy: the Case of Galileo Public-Private Partnership

NASA Astrophysics Data System (ADS)

Zervos, Vasilis

2002-01-01

This paper examines the impact of strategic interactions on Private-Public Partnerships (PPPs) in space. Though there is substantial business and economics literature on PPPs, it is traditionally focused on the relationships within the partnerships (low level) and the respective factors affecting its success. The contribution of this paper is that it examines the political economy of PPPs, analysing how `high-level' strategic interactions across public-private sectors in Europe and the US determine their behaviour and success. Within this context, the European case of Galileo and other national space projects, such as the US plans for a space-based anti- missile defence, are each based on different types of PPPs, confined within the geographical borders of the two areas. The security and commercial benefits of such programmes for the respective space industries and economies have a direct impact on the other area's industry and sense of security. The paper shows that trans- Atlantic cooperation at public policy level is essential to allow the respective industries to explore the benefits of cross-border strategic research partnerships (SRPs). This will reduce the costs of the respective programmes, addressing security concerns.

Investigating a New Way To Teach Law: A Computer-based Commercial Law Course.

ERIC Educational Resources Information Center

Lloyd, Robert M.

2000-01-01

Describes the successful use of an interactive, computer-based format supplemented by online chats to provide a two-credit-hour commercial law course at the University of Tennessee College of Law. (EV)

Research and Energy Efficiency: Selected Success Stories

DOE R&D Accomplishments Database

Garland, P. W.; Garland, R. W.

1997-06-26

Energy use and energy technology play critical roles in the U.S. economy and modern society. The Department of Energy (DOE) conducts civilian energy research and development (R&D) programs for the purpose of identifying promising technologies that promote energy security, energy efficiency, and renewable energy use. DOE-sponsored research ranges from basic investigation of phenomena all the way through development of applied technology in partnership with industry. DOE`s research programs are conducted in support of national strategic energy objectives, however austere financial times have dictated that R&D programs be measured in terms of cost vs. benefit. In some cases it is difficult to measure the return on investment for the basic "curiosity-driven" research, however many applied technology development programs have resulted in measurable commercial successes. The DOE has published summaries of their most successful applied technology energy R&D programs. In this paper, we will discuss five examples from the Building Technologies area of the DOE Energy Efficiency program. Each story will describe the technology, discuss the level of federal funding, and discuss the returns in terms of energy savings, cost savings, or national economic impacts.

16 CFR 802.71 - Acquisitions by gift, intestate succession or devise, or by irrevocable trust.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 16 Commercial Practices 1 2013-01-01 2013-01-01 false Acquisitions by gift, intestate succession... IMPROVEMENTS ACT OF 1976 EXEMPTION RULES § 802.71 Acquisitions by gift, intestate succession or devise, or by irrevocable trust. Acquisitions resulting from a gift, intestate succession, testamentary disposition or...

16 CFR 802.71 - Acquisitions by gift, intestate succession or devise, or by irrevocable trust.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Acquisitions by gift, intestate succession... IMPROVEMENTS ACT OF 1976 EXEMPTION RULES § 802.71 Acquisitions by gift, intestate succession or devise, or by irrevocable trust. Acquisitions resulting from a gift, intestate succession, testamentary disposition or...

16 CFR 802.71 - Acquisitions by gift, intestate succession or devise, or by irrevocable trust.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 16 Commercial Practices 1 2014-01-01 2014-01-01 false Acquisitions by gift, intestate succession... IMPROVEMENTS ACT OF 1976 EXEMPTION RULES § 802.71 Acquisitions by gift, intestate succession or devise, or by irrevocable trust. Acquisitions resulting from a gift, intestate succession, testamentary disposition or...

16 CFR 802.71 - Acquisitions by gift, intestate succession or devise, or by irrevocable trust.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 16 Commercial Practices 1 2011-01-01 2011-01-01 false Acquisitions by gift, intestate succession... IMPROVEMENTS ACT OF 1976 EXEMPTION RULES § 802.71 Acquisitions by gift, intestate succession or devise, or by irrevocable trust. Acquisitions resulting from a gift, intestate succession, testamentary disposition or...

16 CFR 802.71 - Acquisitions by gift, intestate succession or devise, or by irrevocable trust.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 16 Commercial Practices 1 2012-01-01 2012-01-01 false Acquisitions by gift, intestate succession... IMPROVEMENTS ACT OF 1976 EXEMPTION RULES § 802.71 Acquisitions by gift, intestate succession or devise, or by irrevocable trust. Acquisitions resulting from a gift, intestate succession, testamentary disposition or...

Evaluation of a Commercial ELISA for the Detection of Antibodies to Sarcoptes scabiei in Wild Boar (Sus scrofa).

PubMed

Haas, Chloé; Rossi, Sophie; Meier, Roman; Ryser-Degiorgis, Marie-Pierre

2015-07-01

Sarcoptic mange occurs in free-ranging wild boar (Sus scrofa) but has been poorly described in this species. We evaluated the performance of a commercial indirect enzyme-linked immunosorbent assay (ELISA) for serodiagnosis of sarcoptic mange in domestic swine when applied to wild boar sera. We tested 96 sera from wild boar in populations without mange history ("truly noninfected") collected in Switzerland between December 2012 and February 2014, and 141 sera from free-ranging wild boar presenting mange-like lesions, including 50 live animals captured and sampled multiple times in France between May and August 2006 and three cases submitted to necropsy in Switzerland between April 2010 and February 2014. Mite infestation was confirmed by skin scraping in 20 of them ("truly infected"). We defined sensitivity of the test as the proportion of truly infected that were found ELISA-positive, and specificity as the proportion of truly noninfected that were found negative. Sensitivity and specificity were 75% and 80%, respectively. Success of antibody detection increased with the chronicity of lesions, and seroconversion was documented in 19 of 27 wild boar sampled multiple times that were initially negative or doubtful. In conclusion, the evaluated ELISA has been successfully applied to wild boar sera. It appears to be unreliable for early detection in individual animals but may represent a useful tool for population surveys.

Technical and economic assessments commercial success for IGCC technology in China

DOE Office of Scientific and Technical Information (OSTI.GOV)

Xiong, T.

1998-07-01

The experiences gained from several Integrated Gasification Combined Cycle (IGCC) demonstration plants operating in the US and Europe facilitate commercial success of this advanced coal-based power generation technology. However, commercialization of coal-based IGCC technology in the West, particularly in the US, is restricted due to the low price of natural gas. On the contrary, in China--the largest coal producer and consumer in the world--a lack of natural gas supply, strong demand for air pollution control and relatively low costs of manufacturing and construction provide tremendous opportunities for IGCC applications. The first Chinese IGCC demonstration project was initiated in 1994, andmore » other potential IGCC projects are in planning. IGCC applications in re-powering, fuel switching and multi-generation also show a great market potential in China. However, questions for IGCC development in China remain; where are realistic opportunities for IGCC projects and how can these opportunities be converted into commercial success? The answers to these questions should focus on the Chinese market needs and emphasize economic benefits, not just clean, or power. High price of imported equipment, high financing costs, and the technical risk of first-of-a-kind installation barricade IGCC development in China. This paper presents preliminary technical and economic assessments for four typical IGCC applications in the Chinese marketplace: central power station, fuel switching, re-powering, and multi-generation. The major factors affecting project economics--such as plant cost, financing, prices of fuel and electricity and operating capacity factor--are analyzed. The results indicate that well-proven technology for versatile applications, preferred financing, reduction of the plant cost, environmental superiority and appropriate project structure are the key for commercial success of IGCC in China.« less

Failure of molecular diagnostics of a keratitis-inducing Acanthamoeba strain.

PubMed

Scheid, Patrick L; Balczun, Carsten

2017-12-01

An otherwise healthy 49-year-old female patient presented at the local hospital with severe keratitis in both inflamed eyes. She was a contact lens wearer and had no history of a corneal trauma. In our laboratory for medical parasitology Acanthamoebae were detected microscopically from the cornea scraping and from the fluid of the contact lens storage case after xenical culture and showed the typical cyst morphology of Acanthamoebae group II. The diagnosis of "Acanthamoeba keratitis" was established and successful therapy was provided. While the morphological microscopic method led to the correct diagnosis in this case, an in-house multiplex qPCR and a commercial qPCR showed false negative results regarding Acanthamoeba sp. The subsequent sequencing revealed the Acanthamoeba genotype T4. In the present case report, the inability to detect Acanthamoebae using qPCR only is presented. Therefore, we recommend the utilization of combined different assays for optimal diagnostic purposes. Copyright © 2017 Elsevier Inc. All rights reserved.

The Conference Proceedings of the 2001 Air Transport Research Society (ATRS) of the WCTR Society. Volume 1

NASA Technical Reports Server (NTRS)

Lee, Yeong-Heok (Editor); Bowen, Brent D. (Editor); Tarry, Scott E. (Editor)

2001-01-01

The ATRS held its Annual conference at Jeju Island, Korea in July 2001. The conference was a success with nearly 140 participants including 70 presenters. This report contains presentations from Volume 1 on the following: Airline and Travel Agent Relationships in Asia;Benchmarking Aviation Safety in the Commercial Airline Industry;Impact of Frequent Flyer Program on the Demand for Air Travel; Application of Genetic Algorithm on Airline Schedule;The Effects of Dual Carrier Designation and Partial Liberalization: The Case of Canada;Defense of Air Carriers and Air Agencies in FAA Enforcement proceedin gs - Damage Control Before the Case Arises; Cost Incentives for Airline Mergers? - An examination on the cost impact of U.S. airline mergers and acquisitions;Airport Regulation, Airline Competition and Canada's Airport System; Airline Competition: The Case of Israel's Domestic Doupoly; Non-Financial Indicators of Airline Distress: A Conceptual Approach;and Airport Privatization: An Empirical Analysis of Financial and Operational Efficiency.

Space Product Development: NASA Partnering With Industry For Out of This World Results

NASA Technical Reports Server (NTRS)

Nall, Mark E.; Casas, Joe; Powers, Blake; Henderson, Robin N. (Technical Monitor)

2002-01-01

True space commercialization can only be achieved through having the broadest possible industrial participation. Commercial paradigms focused simply on commercial launch operations are not viable since there are limited payload launch opportunities in terms of satellites and similar vehicles, and there are not yet sufficient markets to support large-scale operations and innovation. What is required to expand commercial operations to the point of viability is a broad base of industry that understands the opportunities of commercial space and microgravity operations, and is eager to take advantage of it. Interesting non-aerospace companies in commercial space and microgravity research or operations is a major challenge, since these companies must be educated about the opportunities, introduced into the process in an effective and comfortable manner, and encouraged to continue and expand their work in this area. The NASA Space Product Development Program does this through fifteen Commercial Space Centers located across the United States, each focusing on a different area of interest to industry rather than of interest to NASA. These Centers serve as a consortium of industry, academia, and government, bringing the synergistic effects of membership to the benefit of all. This paper will discuss the guiding philosophies of this program, its organization, the successes obtained by industry in a variety of fields, and the success NASA is experiencing in building the broad base of industry needed to achieve true space commercialization.

Vaccines for fish in aquaculture.

PubMed

Sommerset, Ingunn; Krossøy, Bjørn; Biering, Eirik; Frost, Petter

2005-02-01

Vaccination plays an important role in large-scale commercial fish farming and has been a key reason for the success of salmon cultivation. In addition to salmon and trout, commercial vaccines are available for channel catfish, European seabass and seabream, Japanese amberjack and yellowtail, tilapia and Atlantic cod. In general, empirically developed vaccines based on inactivated bacterial pathogens have proven to be very efficacious in fish. Fewer commercially available viral vaccines and no parasite vaccines exist. Substantial efficacy data are available for new fish vaccines and advanced technology has been implemented. However, before such vaccines can be successfully commercialized, several hurdles have to be overcome regarding the production of cheap but effective antigens and adjuvants, while bearing in mind environmental and associated regulatory concerns (e.g., those that limit the use of live vaccines). Pharmaceutical companies have performed a considerable amount of research on fish vaccines, however, limited information is available in scientific publications. In addition, salmonids dominate both the literature and commercial focus, despite their relatively small contribution to the total volume of farmed fish in the world. This review provides an overview of the fish vaccines that are currently commercially available and some viewpoints on how the field is likely to evolve in the near future.

Safety And Promotion in the Federal Aviation Administration- Enabling Safe and Successful Commercial Space Transportation

NASA Astrophysics Data System (ADS)

Repcheck, Randall J.

2010-09-01

The United States Federal Aviation Administration’s Office of Commercial Space Transportation(AST) authorizes the launch and reentry of expendable and reusable launch vehicles and the operation of launch and reentry sites by United States citizens or within the United States. It authorizes these activities consistent with public health and safety, the safety of property, and the national security and foreign policy interests of the United States. In addition to its safety role, AST has the role to encourage, facilitate, and promote commercial space launches and reentries by the private sector. AST’s promotional role includes, among other things, the development of information of interest to industry, the sharing of information of interest through a variety of methods, and serving as an advocate for Commercial Space Transportation within the United States government. This dual safety and promotion role is viewed by some as conflicting. AST views these two roles as complementary, and important for the current state of commercial space transportation. This paper discusses how maintaining a sound safety decision-making process, maintaining a strong safety culture, and taking steps to avoid complacency can together enable safe and successful commercial space transportation.

WARM-LIQUID DEFROST FOR COMMERCIAL FOOD DISPLAY CASES: EXPERIMENTAL INVESTIGATION AT 32.2 DEGREES C CONDENSING

EPA Science Inventory

The paper gives results of an experimental investigation at 32.2 C condensing of warm-liquid defrost for commercial food display cases. A refrigeration test rig with two open cases and two reach-in cases was tested using warm-liquid defrost (WLD) at -34.4 C evaporating, 32.2 C co...

From clinical proof-of-concept to commercialization of CAR T cells.

PubMed

Calmels, Boris; Mfarrej, Bechara; Chabannon, Christian

2018-04-01

The development of CAR T cells currently represents an exciting opportunity to convert the already published clinical successes observed in clinical trials into commercially available efficient therapies. However, the path toward successful commercialization is still hindered by many hurdles. Here, we review such issues as: the need for structured collaborations between hospital collection and clinical facilities and industry manufacturing facilities to streamline the supply chain; necessity for uniform and efficient medical procedures to cope with severe toxicities associated with CAR T cells; and absolute need to define an economical and sustainable model for manufacturers and payers. The fast pace at which the field is evolving requires careful assessments for the benefit of patients. Copyright © 2018 Elsevier Ltd. All rights reserved.

Implications of previous space commercialization experiences for the reusable launch vehicle

NASA Astrophysics Data System (ADS)

Obermann, Richard M.; Williamson, Ray A.

2003-07-01

The United States' 1994 National Space Transportation Policy directed the National Aeronautics and Space Administration (NASA) to work with industry on the development of technologies required for a reusable launch vehicle (RLV). In the partnership that has evolved from that directive, NASA envisions its role as providing support for technological risk reduction and for developing space transportation to serve government needs. NASA officials assume that the development of an operational, commercial RLV will be carried out by the private sector without use of government funds. Under that scenario, the Federal government will simply become a customer for commercial RLV services. In evaluating the prospects for the development of a commercially viable RLV, it may be useful to examine "lessons learned" from previous space commercialization efforts—both those that succeeded and those that did not. It can be argued that several distinct streams of market and technological development may have to converge for successful commercialization of space systems to occur. Potential factors influencing the prospects for commercialization include the size and growth rate of the potential customer base, the extent to which a governmental customer exists to underpin the market, the development of associated "value-added" markets, the stability of governmental policies, the levels of technological and business risk, and the degree to which competitive markets exist. This paper examines two previous space commercialization experiences, evaluates the relative importance of the various factors that influence the prospects for success of commercialization efforts, and assesses the implications of those factors for the commercial viability of the proposed RLV.

Key Indicators of Successful Logging Jobs in the Northeast

Treesearch

Owen W. Herrick

1976-01-01

Uncertainty and inadequate information for prediction hinder attempts to judge the chances for success on logging jobs. In this study, variation in the success of commercial logging jobs in the Northeast was examined to relate the kinds of conditions present to the chances of logging being most successful under those conditions. Respondents rated half of the sample...

Do Universities Have "Successful" Brands?

ERIC Educational Resources Information Center

Chapleo, Chris

2005-01-01

Branding in universities is a topical issue, but arguably few UK universities have fully developed "successful" brands in the manner of commercial organizations. This qualitative paper explores the opinions of 40 opinion formers on which UK universities have successful brands and the associations these brands have. Current literature on…

The venture space alliance commercial application of microgravity research

NASA Astrophysics Data System (ADS)

Whitton, Dave

1999-01-01

The Venture Space Alliance is a Canadian commercial enterprise formed to develop a successful sustainable business, providing industrial and institutional clients with cost effective timely access to space and microgravity facilities for commercial and scientific benefit. The goal is to offer users a comprehensive and reliable set of products and services from the early stages of research, where access to short duration microgravity such as drop towers, aircraft and sub-orbital rockets is required, to more complex missions requiring free flyers, shuttle or Space Station. The service is designed to relieve the researcher from having to be concerned with the special processes associated with space flight, and to assist in the commercial application of their research through the development of business plans and investment strategy. Much of this research could lead to new and better medicines, high disease tolerant and more prolific agricultural products, new materials and alloys, and improvements in fundamental human health. This paper will describe the commercial successes derived from microgravity research, and the anticipated growth of this segment particularly with the completion of the International Space Station.

Automatic Commercial Permit Sets

DOE Office of Scientific and Technical Information (OSTI.GOV)

Grana, Paul

Final report for Folsom Labs’ Solar Permit Generator project, which has successfully completed, resulting in the development and commercialization of a software toolkit within the cloud-based HelioScope software environment that enables solar engineers to automatically generate and manage draft documents for permit submission.

Assessment of a High Purity Zein Product from Commercial Zein

USDA-ARS?s Scientific Manuscript database

Successful utilization of commercial zein products for food, pharmaceutical, cosmetic and medical applications requires a decolorized/deodorized zein that is substantially undenatured protein. A zein protein product with those qualifications has already been developed by a patent pending process. ...

Computer-generated hologram calculation for real scenes using a commercial portable plenoptic camera

NASA Astrophysics Data System (ADS)

Endo, Yutaka; Wakunami, Koki; Shimobaba, Tomoyoshi; Kakue, Takashi; Arai, Daisuke; Ichihashi, Yasuyuki; Yamamoto, Kenji; Ito, Tomoyoshi

2015-12-01

This paper shows the process used to calculate a computer-generated hologram (CGH) for real scenes under natural light using a commercial portable plenoptic camera. In the CGH calculation, a light field captured with the commercial plenoptic camera is converted into a complex amplitude distribution. Then the converted complex amplitude is propagated to a CGH plane. We tested both numerical and optical reconstructions of the CGH and showed that the CGH calculation from captured data with the commercial plenoptic camera was successful.

The commercial evolution of the Titan program

NASA Astrophysics Data System (ADS)

Isakowitz, Steven

1988-07-01

The present status evaluation of proprietary efforts to turn the once exclusively government-requirements-oriented Titan launch vehicle into a successful commercial competitor is divided into three phases. The first phase notes recent changes in U.S. space transportation policy and the Titan configurations evaluated for commercial feasibility. The second phase is a development history for the current vehicle's marketing organization and the right-to-use agreement for a launch site. Phase three projects the prospective marketing climate for a commercial Titan vehicle and its planned improvements.

Comparative studies on Aedes aegypti and Aedes albopictus adult females trespassing commercial nets.

PubMed

Andrade, Carlos F S; Cabrini, Isaías

2010-03-01

ABSTRACT. The abilities of Aedes aegypti and Ae. albopictus females in trespassing 5 different commercial nets, 2 nets impregnated with deltamethrin or permethrin and 3 non-impregnated nets (Guarany, Perame, and Ricca), were compared. The evaluating parameters were their percent trespassing success, the median trespassing time (TT50), and the relation between mosquito wing sizes and their trespassing success. Some mosquito behavioral traits were also observed. The trespassing success, directly related to opening areas, was found to be lower with impregnated nets for both species. The differences between the mosquito species were significant among all the nets except Ricca. Aedes albopictus showed a very high success rate in trespassing the non-impregnated Perame net and a lower success rate in trespassing Guarany. Aedes albopictus also showed a very high success rate in trespassing pyrethroid-impregnated nets. The TT50 values for the Ricca and Guarany nets were not significantly different between the species, but a significantly lower TT50 value was found for the net with the largest opening (Ricca). The smaller wingspan of Ae. albopictus seems to explain the higher trespassing success of this species.

Establishing a commercial building energy data framework for India

DOE Office of Scientific and Technical Information (OSTI.GOV)

Iyer, Maithili; Kumar, Satish; Mathew, Sangeeta

Buildings account for over 40% of the world’s energy consumption and are therefore a key contributor to a country’s energy as well as carbon budget. Understanding how buildings use energy is critical to understanding how related policies may impact energy use. Data enables decision making, and good quality data arms consumers with the tools to compare their energy performance to their peers, allowing them to differentiate their buildings in the real estate market on the basis of their energy footprint. Good quality data are also essential for policy makers to prioritize their energy saving strategies and track implementation. The Unitedmore » States’ Commercial Building Energy Consumption Survey (CBECS) is an example of a successful data framework that is highly useful for governmental and nongovernmental initiatives related to benchmarking energy forecasting, rating systems and metrics, and more. The Bureau of Energy Efficiency (BEE) in India developed the Energy Conservation Building Code (ECBC) and launched the Star Labeling program for a few energy-intensive building segments as a significant first step. However, a data driven policy framework for systematically targeting energy efficiency in both new construction and existing buildings has largely been missing. There is no quantifiable mechanism currently in place to track the impact of code adoption through regular reporting/survey of energy consumption in the commercial building stock. In this paper we present findings from our study that explored use cases and approaches for establishing a commercial buildings data framework for India.« less

Defined PEG smears as an alternative approach to enhance the search for crystallization conditions and crystal-quality improvement in reduced screens

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chaikuad, Apirat, E-mail: apirat.chaikuad@sgc.ox.ac.uk; Knapp, Stefan; Johann Wolfgang Goethe-University, Building N240 Room 3.03, Max-von-Laue-Strasse 9, 60438 Frankfurt am Main

An alternative strategy for PEG sampling is suggested through the use of four newly defined PEG smears to enhance chemical space in reduced screens with a benefit towards protein crystallization. The quest for an optimal limited set of effective crystallization conditions remains a challenge in macromolecular crystallography, an issue that is complicated by the large number of chemicals which have been deemed to be suitable for promoting crystal growth. The lack of rational approaches towards the selection of successful chemical space and representative combinations has led to significant overlapping conditions, which are currently present in a multitude of commercially availablemore » crystallization screens. Here, an alternative approach to the sampling of widely used PEG precipitants is suggested through the use of PEG smears, which are mixtures of different PEGs with a requirement of either neutral or cooperatively positive effects of each component on crystal growth. Four newly defined smears were classified by molecular-weight groups and enabled the preservation of specific properties related to different polymer sizes. These smears not only allowed a wide coverage of properties of these polymers, but also reduced PEG variables, enabling greater sampling of other parameters such as buffers and additives. The efficiency of the smear-based screens was evaluated on more than 220 diverse recombinant human proteins, which overall revealed a good initial crystallization success rate of nearly 50%. In addition, in several cases successful crystallizations were only obtained using PEG smears, while various commercial screens failed to yield crystals. The defined smears therefore offer an alternative approach towards PEG sampling, which will benefit the design of crystallization screens sampling a wide chemical space of this key precipitant.« less

Pathways to Commercial Success: Technologies and Products Supported by the Fuel Cell Technologies Office - 2015

DOE Office of Scientific and Technical Information (OSTI.GOV)

None, None

2016-01-08

This FY 2015 report updates the results of an effort to identify and document the commercial and emerging (projected to be commercialized within the next 3 to 5 years) hydrogen and fuel cell technologies and products that resulted from U.S. Department of Energy support through the Fuel Cell Technologies Office in the Office of Energy Efficiency and Renewable Energy.

Best practices for health and safety technology transfer in construction.

PubMed

Welch, Laura S; Russell, Dustin; Weinstock, Deborah; Betit, Eileen

2015-08-01

Construction continues to be a dangerous industry, yet solutions that would prevent injury and illness do exist. Prevention of injury and illness among construction workers requires dissemination, adoption, and implementation of these effective interventions, or "research to practice" (r2p). CPWR recruited participants with experience and insight into effective methods for diffusion of health and safety technologies in this industry for a symposium with 3 group sessions and 3 breakout groups. The organizers reviewed session notes and identified 141 recommendations, which were then assigned to 13 over-arching themes. Recommendations included a guide for researchers on patenting and licensing, a business case model, and in-depth case studies including development, testing, manufacturing, marketing, and diffusion. A more comprehensive understanding of the health and safety technology transfer landscape, the various actors, and their motivators and goals will help to foster the successful commercialization and diffusion of health and safety innovations. © 2015 Wiley Periodicals, Inc.

Advanced Commercial Buildings Initiative Final Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Roberts, Sydney G.

The Southface Advanced Commercial Buildings Initiative has developed solutions to overcome market barriers to energy reductions in small commercial buildings by building on the success of four local and Southeast regional energy efficiency deployment programs. These programs address a variety of small commercial building types, efficiency levels, owners, facility manager skills and needs for financing. The deployment programs also reach critical private sector, utility, nonprofit and government submarkets, and have strong potential to be replicated at scale. During the grant period, 200 small commercial buildings participated in Southface-sponsored energy upgrade programs, saving 166,736,703 kBtu of source energy.

Business in orbit - The commercial use of space

NASA Technical Reports Server (NTRS)

Gillam, I. T., IV

1985-01-01

Current and proposed business opportunities in space are discussed. The advantages offered by the zero gravity environment of space are examined. The roles of the Space Shuttle and the Space Station in space commercialization are described. International development and use of the Space Station is proposed. It is observed that the communications satellite industry is a successful space venture, and opportunities for materials processing and pharmaceuticals production in space are considered. The relationship between NASA's Office of Commercial Programs, which assists businesses in space commercialization, and industry is studied. The impact of space commercialization on the national economy and international trade is analyzed.

Commercial speech in crisis: Crisis Pregnancy Center regulations and definitions of commercial speech.

PubMed

Gilbert, Kathryn E

2013-02-01

Recent attempts to regulate Crisis Pregnancy Centers, pseudoclinics that surreptitiously aim to dissuade pregnant women from choosing abortion, have confronted the thorny problem of how to define commercial speech. The Supreme Court has offered three potential answers to this definitional quandary. This Note uses the Crisis Pregnancy Center cases to demonstrate that courts should use one of these solutions, the factor-based approach of Bolger v. Youngs Drugs Products Corp., to define commercial speech in the Crisis Pregnancy Center cases and elsewhere. In principle and in application, the Bolger factor-based approach succeeds in structuring commercial speech analysis at the margins of the doctrine.

"Think different": a qualitative assessment of commercial innovation for diabetes information technology programs.

PubMed

Rupcic, Sonia; Tamrat, Tigest; Kachnowski, Stan

2012-11-01

This study reviews the state of diabetes information technology (IT) initiatives and presents a set of recommendations for improvement based on interviews with commercial IT innovators. Semistructured interviews were conducted with 10 technology developers, representing 12 of the most successful IT companies in the world. Average interview time was approximately 45 min. Interviews were audio-recorded, transcribed, and entered into ATLAS.ti for qualitative data analysis. Themes were identified through a process of selective and open coding by three researchers. We identified two practices, common among successful IT companies, that have allowed them to avoid or surmount the challenges that confront healthcare professionals involved in diabetes IT development: (1) employing a diverse research team of software developers and engineers, statisticians, consumers, and business people and (2) conducting rigorous research and analytics on technology use and user preferences. Because of the nature of their respective fields, healthcare professionals and commercial innovators face different constraints. With these in mind we present three recommendations, informed by practices shared by successful commercial developers, for those involved in developing diabetes IT programming: (1) include software engineers on the implementation team throughout the intervention, (2) conduct more extensive baseline testing of users and monitor the usage data derived from the technology itself, and (3) pursue Institutional Review Board-exempt research.

Searching for Educational Content in the For-Profit Internet: Case Study and Analysis.

ERIC Educational Resources Information Center

Fabos, Bettina

This case study investigates the commercialized nature of Internet content and the ways educators and students negotiate and talk about such content. In factoring in the economic and historical context of educational Internet content, this case study also addresses educators' evolving attitudes towards commercialism in the classroom. A survey was…

Moving to alternative refrigerants. Ten case histories. Comfort coolers, industrial process, and commercial refrigeration. Stratospheric ozone protection

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1993-11-01

Table of Contents: Case Histories: Comfort Coolers; Coventry Management Systems - Texaco Heritage Plaza; New York Life Insurance Company; and Westinghouse Electric Corporation. Case Histories: Industrial Process: Eastman Chemical Company; and DuPont. Case Histories: Commercial Refrigeration: Market Basket Supermarkets; Jitney Jungle Stores of America; Furr's Supermarkets; Emil Villa's Hick'ry Pit Restaurants; and Wawa Convenience Stores.

Organ printing: from bioprinter to organ biofabrication line.

PubMed

Mironov, Vladimir; Kasyanov, Vladimir; Markwald, Roger R

2011-10-01

Organ printing, or the layer by layer additive robotic biofabrication of functional three-dimensional tissue and organ constructs using self-assembling tissue spheroid building blocks, is a rapidly emerging technology that promises to transform tissue engineering into a commercially successful biomedical industry. It is increasingly obvious that similar well-established industries implement automated robotic systems on the path to commercial translation and economic success. The use of robotic bioprinters alone however is not sufficient for the development of large industrial scale organ biofabrication. The design and development of a fully integrated organ biofabrication line is imperative for the commercial translation of organ printing technology. This paper presents recent progress and challenges in the development of the essential components of an organ biofabrication line. Copyright © 2011 Elsevier Ltd. All rights reserved.

Advanced Energy Retrofit Guide: Practical Ways to Improve Energy Performance; Grocery Stores (Revised) (Book)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hendron, B.

2013-07-01

The U.S. Department of Energy developed the Advanced Energy Retrofit Guides (AERGs) to provide specific methodologies, information, and guidance to help energy managers and other stakeholders successfully plan and execute energy efficiency improvements. Detailed technical discussion is fairly limited in these guides. Instead, we emphasize actionable information, practical methodologies, diverse case studies, and unbiased evaluations of the most promising retrofit measures for each building type. A series of AERGs is under development, addressing key segments of the commercial building stock. Grocery stores were selected as one of the highest priority sectors, because they represent one of the most energy-intensive marketmore » segments.« less

Microhole Coiled Tubing Bottom Hole Assemblies

DOE Office of Scientific and Technical Information (OSTI.GOV)

Don Macune

2008-06-30

The original objective of the project, to deliver an integrated 3 1/8-inch diameter Measurement While Drilling (MWD) and Logging While Drilling (LWD) system for drilling small boreholes using coiled tubing drilling, has been achieved. Two prototype systems have been assembled and tested in the lab. One of the systems has been successfully tested downhole in a conventional rotary drilling environment. Development of the 3 1/8-inch system has also lead to development and commercialization of a slightly larger 3.5-inch diameter system. We are presently filling customer orders for the 3.5-inch system while continuing with commercialization of the 3 1/8-inch system. Themore » equipment developed by this project will be offered for sale to multiple service providers around the world, enabling the more rapid expansion of both coiled tubing drilling and conventional small diameter drilling. The project was based on the reuse of existing technology whenever possible in order to minimize development costs, time, and risks. The project was begun initially by Ultima Labs, at the time a small company ({approx}12 employees) which had successfully developed a number of products for larger oil well service companies. In September, 2006, approximately 20 months after inception of the project, Ultima Labs was acquired by Sondex plc, a worldwide manufacturer of downhole instrumentation for cased hole and drilling applications. The acquisition provided access to proven technology for mud pulse telemetry, downhole directional and natural gamma ray measurements, and surface data acquisition and processing, as well as a global sales and support network. The acquisition accelerated commercialization through existing Sondex customers. Customer demand resulted in changes to the product specification to support hotter (150 C) and deeper drilling (20,000 psi pressure) than originally proposed. The Sondex acquisition resulted in some project delays as the resistivity collar was interfaced to a different MWD system and also as the mechanical design was revised for the new pressure requirements. However, the Sondex acquisition has resulted in a more robust system, secure funding for completion of the project, and more rapid commercialization.« less

Benefits of Integration of Aerojet Rocketdyne and RTI Advanced Gasification Technologies for Hydrogen-Rich Syngas Production

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gupta, Vijay; Denton, David; SHarma, Pradeep

The key objective for this project was to evaluate the potential to achieve substantial reductions in the production cost of H 2-rich syngas via coal gasification with near-zero emissions due to the cumulative and synergistic benefits realized when multiple advanced technologies are integrated into the overall conversion process. In this project, Aerojet Rocketdyne’s (AR’s) advanced gasification technology (currently being offered as R-GAS™) and RTI International’s (RTI’s) advanced warm syngas cleanup technologies were evaluated via a number of comparative techno-economic case studies. AR’s advanced gasification technology consists of a dry solids pump and a compact gasifier system. Based on the uniquemore » design of this gasifier, it has been shown to reduce the capital cost of the gasification block by between 40 and 50%. At the start of this project, actual experimental work had been demonstrated through pilot plant systems for both the gasifier and dry solids pump. RTI’s advanced warm syngas cleanup technologies consist primarily of RTI’s Warm Gas Desulfurization Process (WDP) technology, which effectively allows decoupling of the sulfur and CO 2 removal allowing for more flexibility in the selection of the CO 2 removal technology, plus associated advanced technologies for direct sulfur recovery and water gas shift (WGS). WDP has been demonstrated at pre-commercial scale using an activated amine carbon dioxide recovery process which would not have been possible if a majority of the sulfur had not been removed from the syngas by WDP. This pre-commercial demonstration of RTI’s advanced warm syngas cleanup system was conducted in parallel to the activities on this project. The technical data and cost information from this pre-commercial demonstration were extensively used in this project during the techno-economic analysis. With this project, both of RTI’s advanced WGS technologies were investigated. Because RT’s advanced fixed-bed WGS (AFWGS) process was successfully implemented in the WDP pre-commercial demonstration test mentioned above, this technology was used as part of RTI’s advanced warm syngas technology package for the techno-economic analyses for this project. RTI’s advanced transport-reactor-based WGS (ATWGS) process was still conceptual at the start of this project, but one of the tasks for this project was to evaluate the technical feasibility of this technology. In each of the three application-based comparison studies conducted as part of this project, the reference case was based on an existing Department of Energy National Energy Technology Laboratory (DOE/NETL) system study. Each of these references cases used existing commercial technology and the system resulted in > 90% carbon capture. In the comparison studies for the use of the hydrogen-rich syngas generated in either an Integrated Gasification Combined Cycle (IGCC) or a Coal-to-Methanol (CTM) plant, the comparison cases consisted of the reference case, a case with the integration of each individual advanced technology (either AR or RTI), and finally a case with the integration of all the advanced technologies (AR and RTI combined). In the Coal-to-Liquids (CTL) comparison study, the comparison study consisted of only three cases, which included a reference case, a case with just RTI’s advanced syngas cleaning technology, and a case with AR’s and RTI’s advanced technologies. The results from these comparison studies showed that the integration of the advanced technologies did result in substantial benefits, and by far the greatest benefits were achieved for cases integrating all the advanced technologies. For the IGCC study, the fully integrated case resulted in a 1.4% net efficiency improvement, an 18% reduction in capital cost per kW of capacity, a 12% reduction in the operating cost per kWh, and a 75–79% reduction in sulfur emissions. For the CTM case, the fully integrated plant resulted in a 22% reduction in capital cost, a 13% reduction in operating costs, a > 99% net reduction in sulfur emissions, and a reduction of 13–15% in CO 2 emissions. Because the capital cost represents over 60% of the methanol Required Selling Price (RSP), the significant reduction in the capital cost for the advanced technology case resulted in an 18% reduction in methanol RSP. For the CTL case, the fully integrated plant resulted in a 16% reduction in capital cost, which represented a 13% reduction in diesel RSP. Finally, the technical feasibility analysis of RTI’s ATWGS process demonstrated that a fluid-bed catalyst with sufficient attrition resistance and WGS activity could be made and that the process achieved about a 24% reduction in capital cost compared to a conventional fixed-bed commercial process.« less

In-flight automated external defibrillator use and consultation patterns

PubMed Central

Brown, AM; Rittenberger, JC; Ammon, CM; Harrington, S; Guyette, FX

2010-01-01

Background Limited information exists about the in-flight use and outcomes associated with automatic external defibrillators (AED) on commercial airlines. Methods We collected self-reported cases of AED use to an airline consultation service from three US airlines between May 2004 and March 2009. We reviewed all available data files, related consult forms, and recordings. For each case, demographics, initial rhythm, shock delivery/success, survival to admission, and ground medical consultation use were obtained. Success was defined as the return of a perfusing rhythm. Initial rhythms were classified as: sinus, heart block, SVT, atrial fibrillation/flutter, asystole, PEA and VF/VT. Results There were a total of 169 AED applications with 40 cardiac arrests. The mean ages were 58 years (SD 15) and 63 years (SD 12) respectively; both populations were 64% male. AEDs were applied for monitoring in 129 (76%) cases with initial rhythms of: sinus 114 (88%); atrial fibrillation/flutter 7 (5%); complete heart block 4 (3%); and SVT 4 (3%). Presenting rhythms among the cardiac arrest population were: asystole 16 (40%); ventricular fibrillation/ventricular tachycardia 10 (25%); and PEA 14 (35%). Fourteen patients were defibrillated including nine of the 10 patients with initial VF/VT and five for the presence of VF/VT after resuscitation for initial PEA/asystole. Defibrillation was advised but not performed in the remaining case of initial VF/VT and no medical consult was obtained. All five successful defibrillations occurred in patients with initial VF/VT. There were 6 (15%; 95% CI 3–27%) survivors with 5 occurring after successful defibrillation for initial VF/VT and one with return of a perfusing rhythm after CPR for a junctional rhythm. Survival in those with VF/VT was 5/10 (50%; 95% CI 14–86%). Medications were delivered twice. The median time to first shock was 19 (IQR 12–24) seconds from AED application. Medical consultation was obtained in 56 (33%) of the 169 AED cases and 14 (35%) of the cardiac arrests. Conclusion AEDs resulted in 50% survival among those with VT/VF in-flight and 14% overall survival for cardiac arrest. Survival is poor among patients presenting with non-shockable rhythms. AEDs are used extensively for in-flight monitoring with significant rhythms identified. Ground medical consultation is sought in only one-third of AED uses and cardiac arrests. PMID:20128705

Type C botulism in a commercial turkey farm: a case report.

PubMed

Popp, Christina; Hauck, Rüdiger; Gad, Wael; Hafez, Hafez M

2012-12-01

Botulism is an intoxication caused by exotoxins of Clostridium botulinum. The case of botulism described here occurred on a commercial meat turkey farm with two houses. Toms and hens were maintained in two separate houses, toms in house A and hens in house B. At 10 wk of age, an increase in mortality was observed in the toms located in house A. Clinically the animals presented with paralysis of the legs, wings, and neck. Affected birds were sitting and reluctant to move. Necropsy failed to find any specific lesions. In liver, heart, muscles, crop, and gizzard as well as in intestinal contents, DNA of C. botulinum type C was detected by PCR. The result was confirmed by a mouse lethality neutralization test. During the 2 wk after the onset of the clinical signs the mortality was about 12%. The hens kept in house B did not show any symptoms and remained healthy. Investigations of environmental samples to detect the source of the toxin were not successful. After 2 wk clinical signs and mortality abated. At 16 wk of age, toms again showed the same clinical signs accompanied by raised mortality. Again C. botulinum toxin type C was detected. Within 2 wk the total mortality reached roughly 50%. Based on the "precautionary principle" and in agreement with the local authorities, the birds were euthanatized using CO2 in order to not compromise food safety.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nabeel Riza

In this program, Nuonics, Inc. has studied the fundamentals of a new Silicon Carbide (SiC) materials-based optical sensor technology suited for extreme environments of coal-fired engines in power production. The program explored how SiC could be used for sensing temperature, pressure, and potential gas species in a gas turbine environment. The program successfully demonstrated the optical designs, signal processing and experimental data for enabling both temperature and pressure sensing using SiC materials. The program via its sub-contractors also explored gas species sensing using SiC, in this case, no clear commercially deployable method was proven. Extensive temperature and pressure measurement datamore » using the proposed SiC sensors was acquired to 1000 deg-C and 40 atms, respectively. Importantly, a first time packaged all-SiC probe design was successfully operated in a Siemens industrial turbine rig facility with the probe surviving the harsh chemical, pressure, and temperature environment during 28 days of test operations. The probe also survived a 1600 deg-C thermal shock test using an industrial flame.« less

First Amendment Limits on Compulsory Speech.

PubMed

Barrella, Nigel

Government-mandated labeling requirements have a long history, and are used extensively by FDA in regulating the industries under its jurisdiction. All such requirements can be characterized as a form of “compelled speech,” opening the door to First Amendment challenges. And some of these challenges, depending on the nature of the labeling requirement, have even been successful. Under Zauderer v. Office of Disciplinary Counsel of Supreme Court of Ohio, regulations that compel disclosure of information will, in many cases, merit only very limited First Amendment scrutiny—less, even, than most other regulations of commercial speech, which receive a type of “intermediate scrutiny.” The labeling requirement that can best avoid or overcome a First Amendment challenge, therefore, will follow the example of the regulation described in Zauderer. For example, Zauderer applied its lower scrutiny by noting that the compelled speech at issue was a disclosure of “purely factual and uncontroversial information.” Conversely, a successful First Amendment challenge to a labeling requirement will often involve an argument that the labeling requirement is outside the scope of what the Zauderer Court contemplated: so, for example, one may argue that a compelled disclosure is either “not factual” or else “controversial,” putting it beyond Zauderer’s reach. After briefly reviewing the major Supreme Court cases that establish the levels of scrutiny for commercial speech and compelled disclosures, the paper will discuss how the various elements of Zauderer have been analyzed by several lower courts, and how some courts have distinguished Zauderer in the context of labeling and other mandatory disclosure laws. In particular, the paper will focus on cases involving First Amendment challenges to food, tobacco, and drug labeling requirements—some successful, some not, and some ongoing—including cases challenging FDA, USDA, and state-level labeling requirements. The decided cases do not all agree on how to understand the elements of Zauderer—for example, must a disclosure be factually controversial to fall outside of Zauderer’s limited review, or may it be factually unquestionable but relating to a controversial topic? What role, if any, should public acceptance, knowledge, and history play? What sorts of interests may the government invoke to justify a labeling requirement? Although some courts have taken (or at least hinted at) strict limits on the meaning of Zauderer, most courts have read Zauderer as applying somewhat more expansively to circumstances beyond its facts. The paper concludes that generally, courts have read Zauderer more expansively in part because such a reading is consistent with existing, familiar labeling requirements, and a narrow reading of Zauderer limited to its facts would rest on a slippery slope to abolishing many accepted and historically unquestioned labeling requirements. Any future attempts to expand judicial review of labeling requirements would do well to highlight limiting principles that address such concerns.

Assessing the memorization of TV commercials with the use of high resolution EEG: a pilot study.

PubMed

Astolfi, L; Soranzo, R; Cincotti, F; Mattia, D; Scarano, G; Gaudiano, I; Marciani, M G; Salinari, S; De Vico Fallani, F; Babiloni, F

2008-01-01

The present work intends to evaluate the functional characteristics of the cerebral network during the successful memory encoding of TV commercials. We estimated the functional networks in the frequency domain from a set of high-resolution EEG data. High resolution EEG recordings were performed in a group of healthy subjects and the cortical activity during the observation of TV commercials was evaluated in several regions of interest coincident with the Brodmann areas (BAs). Summarizing the main results of the present study, a sign of the memorization of a particular set of TV commercials have been found in a group of investigated subjects with the aid of advanced modern tools for the acquisition and the processing of EEG data. The cerebral processes involved during the observation of TV commercials that were remembered successively by the population examined (RMB dataset) are generated by the posterior parietal cortices and the prefrontal areas, rather bilaterally and are irrespective of the frequency bands analyzed. Such results are compatible with previously results obtained from EEG recordings with superficial electrodes as well as with the brain activations observed with the use of MEG and fMRI devices.

Evaluation of commercial DNA and RNA extraction methods for high-throughput sequencing of FFPE samples.

PubMed

Kresse, Stine H; Namløs, Heidi M; Lorenz, Susanne; Berner, Jeanne-Marie; Myklebost, Ola; Bjerkehagen, Bodil; Meza-Zepeda, Leonardo A

2018-01-01

Nucleic acid material of adequate quality is crucial for successful high-throughput sequencing (HTS) analysis. DNA and RNA isolated from archival FFPE material are frequently degraded and not readily amplifiable due to chemical damage introduced during fixation. To identify optimal nucleic acid extraction kits, DNA and RNA quantity, quality and performance in HTS applications were evaluated. DNA and RNA were isolated from five sarcoma archival FFPE blocks, using eight extraction protocols from seven kits from three different commercial vendors. For DNA extraction, the truXTRAC FFPE DNA kit from Covaris gave higher yields and better amplifiable DNA, but all protocols gave comparable HTS library yields using Agilent SureSelect XT and performed well in downstream variant calling. For RNA extraction, all protocols gave comparable yields and amplifiable RNA. However, for fusion gene detection using the Archer FusionPlex Sarcoma Assay, the truXTRAC FFPE RNA kit from Covaris and Agencourt FormaPure kit from Beckman Coulter showed the highest percentage of unique read-pairs, providing higher complexity of HTS data and more frequent detection of recurrent fusion genes. truXTRAC simultaneous DNA and RNA extraction gave similar outputs as individual protocols. These findings show that although successful HTS libraries could be generated in most cases, the different protocols gave variable quantity and quality for FFPE nucleic acid extraction. Selecting the optimal procedure is highly valuable and may generate results in borderline quality specimens.

Pathways to Commercial Success: Technologies and Innovations Enabled by the U.S. Department of Energy Fuel Cell Technologies Office

DOE Office of Scientific and Technical Information (OSTI.GOV)

None, None

This report published in October 2017 updates the results of an effort to identify and document the commercial and emerging (projected to be commercialized within the next 3 to 5 years) hydrogen and fuel cell technologies and products that resulted from U.S. Department of Energy support through the Fuel Cell Technologies Office in the Office of Energy Efficiency and Renewable Energy.

The use of entomopathogenic nematodes in the US and issues related to genetic degradation

USDA-ARS?s Scientific Manuscript database

Research and commercial application of entomopathogenic nematodes in North America has a long history. In the pursuit of commercial viability, there have been a number of success stories, but also quite a number of dead ends. We provide insight into new opportunities for entomopathogenic nematodes...

Company's Unusual Plan to Package Commercial Software with Business Textbooks Produces a Measure of Success.

ERIC Educational Resources Information Center

Watkins, Beverly T.

1992-01-01

Course Technology Inc. has developed 10 products combining textbooks with commercial software for college accounting, business, computer science, and statistics courses. Five of the products use Lotus 1-2-3 spreadsheet software. The products have been positively received by teachers and students. (DB)

Response to House Joint Resolution #135, 1986 session requesting the Board of Education to evaluate the public and commercial school driver education programs.

DOT National Transportation Integrated Search

1986-01-01

The study analyzed the effectiveness of commercial school programs, concluded that students successfully completing their driving instruction at these schools had driving records worse than those for students completing their instruction in the publi...

School Food Service -- Three Points of View.

ERIC Educational Resources Information Center

Flambert, Richard

A food-systems consultant and designer advises school districts that want prosperous food service programs to adopt big-business methods. Successful commercial operations hire top food-service consultants and designers to get the most from their space, equipment, and labor. Commercial enterprises are concerned with efficient utilization of plant…

First Li-Ion Battery On-Board A Russian Commercial Geo Satellite

NASA Astrophysics Data System (ADS)

Masgrangeas, David; Lagattu, Benoit; Nesterishin, Michael; Krenko, Alexander

2011-10-01

This paper deals with the first integration of a Li-ion battery from a western company aboard a Russian commercial GEO satellite. State of the art electrochemistry allied with innovative battery design lead to successful contract for development, manufacturing and delivery of flight hardware. After several months of joint technical work, two batteries were delivered for integration and tested inside a GEO spacecraft. Delivery conditions of a Li-ion battery were also part of the challenge and were successfully filled by both parties. This paper presents the first results of interfacing batteries and spacecraft. Mechanical, thermal and electrical aspects are discussed as well as learned lessons. Beyond cultural and technical habits and despite language barriers, this contract was a true success story between two major companies, each leading its own market share.

Innovation in industry and the diffusion of technology.

PubMed

Utterback, J M

1974-02-15

The varied definitions used in the sources that have been discussed make any aggregate analysis difficult. A simple three-stage analysis of flows to, from, and within the firm was used to facilitate comparisons. Even so, each of the generalizations is drawn from relatively small and unrepresentative samples. Case studies may continue to be a source of ideas and hypotheses for further research, but do not appear to offer a means for deeper understanding of the innovation process. The retrospective nature of nearly all of the sources discussed probably means that the process has been viewed as much more rational and well-ordered than it is in fact. This failing is partially overcome in firsthand accounts such as those of Suites and Bueche (63) and Frey and Goldman (64). Each of these accounts involves a successful innovation according to technical or commercial criteria, or both. However, many of the characteristics of innovations that have failed commercially (10) appear to be similar to those of successful cases. The few longitudinal studies, and studies comparing more and less successful cases, do support the main conclusions drawn above (10, 32, 38). More serious problems are raised by the distinctly nonrepresentative nature of the samples used. There are few cases (17, 33, 65) in which the contributions of more than one organization, or details of interactions over a significant period of time, are discussed. There is a wide variation in the importance of the innovations included, ranging from those affecting the economy as a whole to cases involving production in a single firm, albeit with significant commercial results (66). In addition to questions of comparability and sampling, a central problem for further research on innovation will be to devise an operational model to account for interfirm and interindustry differences. Polar definitions used in past studies, "high technology" and "mature industry," for example, are insufficient. One possibility is to use the strategy for growth or competition evident in a firm or an industry, such as sales maximization (automotive), cost minimization (transportation, communications), performance maximization (aircraft, chemicals), or control of materials resources (mining, petroleum), as a basis for drawing distinctions (67). For example, in an industry that seeks to maximize sales, one would expect innovations that would be highly visible to consumers to be developed rapidly (68). In a cost-minimizing situation, production, as opposed to product technology, would be a major source of uncertainty, while the reverse might be the case in a performance-maximizing situation. Greater uncertainty arising from technical sources would imply greater sophistication in effective firms' product planning approaches, while a more stable technology would imply greater sophistication in market research and market-oriented strategies for innovation, and so forth. Much more work is needed along these lines if outcomes of interventions in the innovative process are to be predicted with any accuracy. Some implications for providing incentives and reducing barriers do seem clear from the work to date. Effective directions for federal action lie in strategies such as creating new markets through purchases or procurement policies; aggregating or focusing markets through regulation and other means; providing for market entry by contracts to smaller firms, venture capital, stronger patent protection, and so on; and providing for mobility and informal contacts within the technical community. Technology "push" strategies (such as tax incentives) to increase most research spending, prizes for new technology, and documentation and information retrieval systems would probably be less important in stimulating innovation. Definitive answers will require the most difficult kind of research-experiments in the field. Since the interventions required are difficult and expensive in most cases, they will not be under the researcher's control. Nor will the effect of policy changes be visible over a short period. Thus it seems imperative to take advantage of interventions that occur fortuitously to construct "quasi-experiments" (69) with as great a degree of control over other factors as possible. For example, have recent changes in policy regarding federally held patents increased the commercial use of these patents? Have changes in the capital gains laws retarded the development and growth of "spin-off" enterprises? Has the identification of technology gaps (3) and competitive opportunities stimulated innovation? The effects of such actions on technical innovation could be carefully observed with a modest but sustained research effort, which promises to yield valuable information beyond that available from largely historical sources.

Protein Engineering: Case Studies of Commercialized Engineered Products

ERIC Educational Resources Information Center

Walsh, Gary

2007-01-01

Programs in biochemistry invariably encompass the principles of protein engineering. Students often display increased understanding and enthusiasm when theoretical concepts are underpinned by practical example. Herein are presented five case studies, each focusing upon a commercial protein product engineered to enhance its application-relevant…

Commercialization Trends in Higher Education: The Costa Rican Case.

ERIC Educational Resources Information Center

Guido, Maria de Los Angeles

1999-01-01

This case study of the commercialized teaching profession in Costa Rican higher education urges circumspection; the term "efficient and productive change" camouflages the state-sanctioned commodification of the instructional enterprise. Courses are becoming proprietary courseware, machinery for selling intellectual capital is emerging,…

Ethical implications of medical crowdfunding: the case of Charlie Gard.

PubMed

Dressler, Gabrielle; Kelly, Sarah A

2018-05-04

Patients are increasingly turning to medical crowdfunding as a way to cover their healthcare costs. In the case of Charlie Gard, an infant born with encephalomyopathic mitochondrial DNA depletion syndrome, crowdfunding was used to finance experimental nucleoside therapy. Although this treatment was not provided in the end, we will argue that the success of the Gard family's crowdfunding campaign reveals a number of potential ethical concerns. First, this case shows that crowdfunding can change the way in which communal healthcare resources are allocated. Second, within the UK's National Health Service, healthcare is ostensibly not a market resource; thus, permitting crowdfunding introduces market norms that could commodify healthcare. Third, pressures inherent to receiving funds from external parties may threaten the ability of patients-cum-recipients to voluntarily consent to treatment. We conclude that while crowdfunding itself is not unethical, its use can have unforeseen consequences that may influence conceptions of healthcare and how it is delivered. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Development of a Cross-Flow Fan Rotor for Vertical Take-Off and Landing Aircraft

DTIC Science & Technology

2013-06-01

ANSYS CFX , along with the commercial computer-aided design software SolidWorks, was used to model and perform a parametric study on the number of rotor...the results found using ANSYS CFX . The experimental and analytical models were successfully compared at speeds ranging from 4,000 to 7,000 RPM...will make vertical take-off possible. The commercial computational fluid dynamics software ANSYS CFX , along with the commercial computer-aided design

Factors influencing nanotechnology commercialization: an empirical analysis of nanotechnology firms in South Korea

NASA Astrophysics Data System (ADS)

Lee, Cheol-Ju; Lee, SuKap; Jhon, Myung S.; Shin, Juneseuk

2013-02-01

Nanotechnology is a representative emerging technology in an embryonic stage. Due to the continuous support provided by both the public and private sectors of many countries, nanotechnologies have increasingly been commercialized in a wide array of industries, but also produce many commercialization failures. Tackling this problem, we investigate key factors affecting the commercialization of nanotechnologies. Identifying key factors of nanotechnology commercialization through literature review and interview with CEOs, we collected data of 206 Korean nanotechnology-based companies, and analyzed the causal relationship between key factors and financial performance. Logistic and Tobit regression models are used. Overall, companies achieving successful commercialization hold some common characteristics including consistent exploratory R&D, governmental funding, and nano-instrument/energy/environment-related products. Also, the use of potentially toxic materials makes commercialization difficult even if the products are not toxic.

Commercial UAV operations in civil airspace

NASA Astrophysics Data System (ADS)

Newcome, Laurence R.

2000-11-01

The Federal Aviation Administration is often portrayed as the major impediment to unmanned aerial vehicle expansion into civil government and commercial markets. This paper describes one company's record for successfully negotiating the FAA regulations and obtaining authorizations for several types of UAVs to fly commercial reconnaissance missions in civil airspace. The process and criteria for obtaining such authorizations are described. The mishap records of the Pioneer, Predator and Hunter UAVs are examined in regard to their impact on FAA rule making. The paper concludes with a discussion of the true impediments to UAV penetration of commercial markets to date.

Development of an Introductory Commercial Spanish Course: Collaboration of the Mead Packing Co. & Kennesaw College.

ERIC Educational Resources Information Center

Holzman, Judy Myers

A collaborative effort of the business community and Kennesaw College (Georgia) resulted in the development of and implementation of an introductory commercial Spanish course that has been successful in introducing students to business practices in a Spanish-speaking environment. Previously, a translation service had been developed by the…

Software Assurance Challenges for the Commercial Crew Program

NASA Technical Reports Server (NTRS)

Cuyno, Patrick; Malnick, Kathy D.; Schaeffer, Chad E.

2015-01-01

This paper will provide a description of some of the challenges NASA is facing in providing software assurance within the new commercial space services paradigm, namely with the Commercial Crew Program (CCP). The CCP will establish safe, reliable, and affordable access to the International Space Station (ISS) by purchasing a ride from commercial companies. The CCP providers have varying experience with software development in safety-critical space systems. NASA's role in providing effective software assurance support to the CCP providers is critical to the success of CCP. These challenges include funding multiple vehicles that execute in parallel and have different rules of engagement, multiple providers with unique proprietary concerns, providing equivalent guidance to all providers, permitting alternates to NASA standards, and a large number of diverse stakeholders. It is expected that these challenges will exist in future programs, especially if the CCP paradigm proves successful. The proposed CCP approach to address these challenges includes a risk-based assessment with varying degrees of engagement and a distributed assurance model. This presentation will describe NASA IV&V Program's software assurance support and responses to these challenges.

Recent advances in AM OLED technologies for application to aerospace and military systems

NASA Astrophysics Data System (ADS)

Sarma, Kalluri R.; Roush, Jerry; Chanley, Charles

2012-06-01

While initial AM OLED products have been introduced in the market about a decade ago, truly successful commercialization of OLEDs has started only a couple of years ago, by Samsung Mobile Display (SMD), with small high performance displays for smart phone applications. This success by Samsung has catalyzed significant interest in AM OLED technology advancement and commercialization by other display manufacturers. Currently, significant manufacturing capacity for AM OLED displays is being established by the industry to serve the growing demand for these displays. The current development in the AM OLED industry are now focused on the development and commercialization of medium size (~10") AM OLED panels for Tablet PC applications and large size (~55") panels for TV applications. This significant progress in commercialization of AM OLED technology is enabled by major advances in various enabling technologies that include TFT backplanes, OLED materials and device structures and manufacturing know-how. In this paper we will discuss these recent advances, particularly as they relate to supporting high performance applications such as aerospace and military systems, and then discuss the results of the OLED testing for aerospace applications.

Embolization of palpebral and orbito-frontal fistulas: technical and anatomical considerations in treating high-flow superficial skin lesions with liquid embolics.

PubMed

Samaniego, Edgar A; Fisher, Mark; Hasan, David; Guerrero, Waldo R; Fifi, Johanna T; Bottani, Laura; Ortega-Gutierrez, Santiago

2018-03-01

The treatment of palpebral and periorbital fistulas may be challenging due to the presence of multiple anastomosis with eloquent ophthalmic and intracranial vascular territories. Moreover, cosmetic and functional characteristics of this area pose unique challenges to open surgical approaches and endovascular therapy. We review the advantages and disadvantages of different liquid embolics in treating palpebral and periorbital fistulas as we describe three successfully treated cases. Moreover, we describe important anatomical landmarks that should be considered at the time of treatment of these lesions. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

The early career researcher's toolkit: translating tissue engineering, regenerative medicine and cell therapy products.

PubMed

Rafiq, Qasim A; Ortega, Ilida; Jenkins, Stuart I; Wilson, Samantha L; Patel, Asha K; Barnes, Amanda L; Adams, Christopher F; Delcassian, Derfogail; Smith, David

2015-11-01

Although the importance of translation for the development of tissue engineering, regenerative medicine and cell-based therapies is widely recognized, the process of translation is less well understood. This is particularly the case among some early career researchers who may not appreciate the intricacies of translational research or make decisions early in development which later hinders effective translation. Based on our own research and experiences as early career researchers involved in tissue engineering and regenerative medicine translation, we discuss common pitfalls associated with translational research, providing practical solutions and important considerations which will aid process and product development. Suggestions range from effective project management, consideration of key manufacturing, clinical and regulatory matters and means of exploiting research for successful commercialization.

Metal Injection Molding of Thin-Walled Titanium Glasses Arms: A Case Study

NASA Astrophysics Data System (ADS)

Ye, Shulong; Mo, Wei; Lv, Yonghu; Li, Xia; Kwok, Chi Tat; Yu, Peng

2018-02-01

Commercially pure titanium (CP Ti) and Ti-6Al-4V arms for a new brand of augmented reality smart glasses, which are over 170 mm in length, with thin wall structures and extremely complex surfaces, have been successfully fabricated via metal injection molding. After sintering, both the metal injection-molded (MIMed) CP Ti and Ti-6Al-4V can reach relative densities of over 95% with an oxygen content 2200 ppm, thus imparting mechanical properties comparable to cast alloys. The ductility of the MIMed CP Ti and Ti-6Al-4V are about 15% and 8%, respectively. This is a good example of applying metal injection molding to mass production of precise Ti alloy parts with complicated shapes.

Electromagnetic Launch Vehicle Fairing and Acoustic Blanket Model of Received Power Using FEKO

NASA Technical Reports Server (NTRS)

Trout, Dawn H.; Stanley, James E.; Wahid, Parveen F.

2011-01-01

Evaluating the impact of radio frequency transmission in vehicle fairings is important to electromagnetically sensitive spacecraft. This study employs the multilevel fast multipole method (MLFMM) from a commercial electromagnetic tool, FEKO, to model the fairing electromagnetic environment in the presence of an internal transmitter with improved accuracy over industry applied techniques. This fairing model includes material properties representative of acoustic blanketing commonly used in vehicles. Equivalent surface material models within FEKO were successfully applied to simulate the test case. Finally, a simplified model is presented using Nicholson Ross Weir derived blanket material properties. These properties are implemented with the coated metal option to reduce the model to one layer within the accuracy of the original three layer simulation.

Lorcaserin Use in the Management of Morbid Obesity in a Pre-Liver Transplant Patient.

PubMed

Gutierrez, Julio A; Landaverde, Carmen; Wells, Jennifer T; Poordad, Fred

2016-07-01

Management of obesity and decompensated cirrhosis in those requiring liver transplantation (LT) is a challenging dilemma. Because of concerns for perioperative complications, many centers avoid transplant in those with a body mass index (BMI) greater than 40 kg/m(2) . Bariatric surgery is associated with increased risk attributable to complications of portal hypertension, including variceal rupture. Therefore, weight loss and LT options are limited. Several new classes of weight loss drugs are commercially available, including the anoretic, lorcaserin. This case illustrates the successful use of lorcaserin in a morbidly obese individual with decompensated cirrhosis evaluated for LT listing. (Hepatology 2016;64:301-302). © 2016 by the American Association for the Study of Liver Diseases.

To give or sell human gametes--the interplay between pragmatics, policy and ethics.

PubMed

Daniels, K R

2000-06-01

The ever-growing acceptance and use of assisted human reproduction techniques has caused demand for "donated" sperm and eggs to outstrip supply. Medical professionals and others argue that monetary reward is the only way to recruit sufficient numbers of "donors". Is this a clash between pragmatics and policy/ethics? Where monetary payments are the norm, alternative recruitment strategies used successfully elsewhere may not have been considered, nor the negative consequences of commercialism on all participants thought through. Considerations leading some countries to ban the buying and selling of sperm, eggs and embryos are outlined and a case made that the collective welfare of all involved parties be the primary consideration in this, at times heated, debate.

Barriers and facilitators to learn and improve through morbidity and mortality conferences: a qualitative study.

PubMed

de Vos, Marit S; Hamming, Jaap F; Marang-van de Mheen, Perla J

2017-11-12

To explore barriers and facilitators to successful morbidity and mortality conferences (M&M), driving learning and improvement. This is a qualitative study with semistructured interviews. Inductive, thematic content analysis was used to identify barriers and facilitators, which were structured across a pre-existing framework for change in healthcare. Dutch academic surgical department with a long tradition of M&M. An interview sample of surgeons, residents and physician assistants (n=12). A total of 57 barriers and facilitators to successful M&M, covering 18 themes, varying from 'case type' to 'leadership', were perceived by surgical staff. While some factors related to M&M organisation, others concerned individual or social aspects. Eight factors, of which four were at the social level, had simultaneous positive and negative effects (eg, 'hierarchy' and 'team spirit'). Mediating pathways for M&M success were found to relate to available information , staff motivation and realisation processes. This study provides leads for improvement of M&M practice, as well as for further research on key elements of successful M&M. Various factors were perceived to affect M&M success, of which many were individual and social rather than organisational factors, affecting information and realisation processes but also staff motivation. Based on these findings, practical recommendations were formulated to guide efforts towards best practices for M&M. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Towards Dynamic Authentication in the Grid — Secure and Mobile Business Workflows Using GSet

NASA Astrophysics Data System (ADS)

Mangler, Jürgen; Schikuta, Erich; Witzany, Christoph; Jorns, Oliver; Ul Haq, Irfan; Wanek, Helmut

Until now, the research community mainly focused on the technical aspects of Grid computing and neglected commercial issues. However, recently the community tends to accept that the success of the Grid is crucially based on commercial exploitation. In our vision Foster's and Kesselman's statement "The Grid is all about sharing." has to be extended by "... and making money out of it!". To allow for the realization of this vision the trust-worthyness of the underlying technology needs to be ensured. This can be achieved by the use of gSET (Gridified Secure Electronic Transaction) as a basic technology for trust management and secure accounting in the presented Grid based workflow. We present a framework, conceptually and technically, from the area of the Mobile-Grid, which justifies the Grid infrastructure as a viable platform to enable commercially successful business workflows.

Development of optimized PPP insulated pipe-cable systems in the commercial voltage range

DOE Office of Scientific and Technical Information (OSTI.GOV)

Allam, E.M.; McKean, A.L.

1992-05-01

The primary objectives of this project included the development of an alternate domestic source of Paper-Polypropylene-Paper (PPP) laminate and the development of optimized designs for PPP-insulated pipe-type cable systems in the commercial voltage range. The development of a domestic source of PPP laminate was successfully completed. This laminate was utilized throughout the program for fabrication of full-size prototype cables submitted for laboratory qualification tests. Selected cables at rated voltages of 138, 230 and 345kV have been designed, fabricated and subjected to the series of qualification tests leading to full laboratory qualification. An optimized design of 2000 kcmil, 345kV cable insulatedmore » with 600 mils of domestic PPP laminate was fabricated and successfully passed all laboratory qualification tests. This cable design was subsequently installed at Waltz Mill to undergo the series of field tests leading to full commercial qualification.« less

Development of optimized PPP insulated pipe-cable systems in the commercial voltage range. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Allam, E.M.; McKean, A.L.

1992-05-01

The primary objectives of this project included the development of an alternate domestic source of Paper-Polypropylene-Paper (PPP) laminate and the development of optimized designs for PPP-insulated pipe-type cable systems in the commercial voltage range. The development of a domestic source of PPP laminate was successfully completed. This laminate was utilized throughout the program for fabrication of full-size prototype cables submitted for laboratory qualification tests. Selected cables at rated voltages of 138, 230 and 345kV have been designed, fabricated and subjected to the series of qualification tests leading to full laboratory qualification. An optimized design of 2000 kcmil, 345kV cable insulatedmore » with 600 mils of domestic PPP laminate was fabricated and successfully passed all laboratory qualification tests. This cable design was subsequently installed at Waltz Mill to undergo the series of field tests leading to full commercial qualification.« less

Customizing graphical user interface technology for spacecraft control centers

NASA Technical Reports Server (NTRS)

Beach, Edward; Giancola, Peter; Gibson, Steven; Mahmot, Ronald

1993-01-01

The Transportable Payload Operations Control Center (TPOCC) project is applying the latest in graphical user interface technology to the spacecraft control center environment. This project of the Mission Operations Division's (MOD) Control Center Systems Branch (CCSB) at NASA Goddard Space Flight Center (GSFC) has developed an architecture for control centers which makes use of a distributed processing approach and the latest in Unix workstation technology. The TPOCC project is committed to following industry standards and using commercial off-the-shelf (COTS) hardware and software components wherever possible to reduce development costs and to improve operational support. TPOCC's most successful use of commercial software products and standards has been in the development of its graphical user interface. This paper describes TPOCC's successful use and customization of four separate layers of commercial software products to create a flexible and powerful user interface that is uniquely suited to spacecraft monitoring and control.

A Critical View of Current State of Phytotechnologies to Remediate Soils: Still a Promising Tool?

PubMed Central

Conesa, Héctor M.; Evangelou, Michael W. H.; Robinson, Brett H.; Schulin, Rainer

2012-01-01

Phytotechnologies are often shown as an emerging tool to remediate contaminated soils. Research in this field has resulted in many important findings relating to plant and soil sciences. However, there have been scant private and public investments and little commercial success with this technology. Here, we investigate the barriers to the adoption of phytotechnologies and determine whether it is still a fertile area for future research. The terminology used in phytotechnologies includes a confusing mish-mash of terms relating to concepts and processes increasing the difficulty of developing a unique commercial image. We argue that the commercial success of phytotechnologies depends on the generation of valuable biomass on contaminated land, rather than a pure remediation technique that may not compare favourably with the costs of inaction or alternative technologies. Valuable biomass includes timber, bioenergy, feedstock for pyrolosis, biofortified products, or ecologically important species. PMID:22272168

77 FR 14480 - Defense Federal Acquisition Regulation Supplement: Commercial Determination Approval (DFARS Case...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-12

... acquisitions made pursuant to Federal Acquisition Regulation (FAR) 12.102(f)(1).'' This language clarifies that... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System 48 CFR Part 212 RIN 0750-AH61 Defense Federal Acquisition Regulation Supplement: Commercial Determination Approval (DFARS Case 2011-D041) AGENCY...

A Case Against First Amendment Protections for Commercial Advertising.

ERIC Educational Resources Information Center

Middleton, Kent R.

Although extending constitutional protection to commercial expression might benefit the consumer, the First Amendment is the wrong instrument for carrying out what are basically economic policies. While in most First Amendment cases the nature of the content determines whether it is constitutionally protected, advertising is distinct in that it…

The Commercial Speech Doctrine.

ERIC Educational Resources Information Center

Luebke, Barbara F.

In its 1942 ruling in the "Valentine vs. Christensen" case, the Supreme Court established the doctrine that commercial speech is not protected by the First Amendment. In 1975, in the "Bigelow vs. Virginia" case, the Supreme Court took a decisive step toward abrogating that doctrine, by ruling that advertising is not stripped of…

How Past Loss of Control Accidents May Inform Safety Cases for Advanced Control Systems on Commercial Aircraft

NASA Technical Reports Server (NTRS)

Holloway, C. M.; Johnson, C. W.

2008-01-01

This paper describes five loss of control accidents involving commercial aircraft, and derives from those accidents three principles to consider when developing a potential safety case for an advanced flight control system for commercial aircraft. One, among the foundational evidence needed to support a safety case is the availability to the control system of accurate and timely information about the status and health of relevant systems and components. Two, an essential argument to be sustained in the safety case is that pilots are provided with adequate information about the control system to enable them to understand the capabilities that it provides. Three, another essential argument is that the advanced control system will not perform less safely than a good pilot.

Nesting and foraging behavior of red-winged blackbirds in stormwater wetlands

USGS Publications Warehouse

Sparling, D.W.; Eisemann, J.; Kuenzel, W.

2007-01-01

Stormwater wetlands are a common part of urban and suburban landscapes. These constructed wetlands provide first-order treatment of effluent from roads, parking lots, lawns and other surfaces. They also provide habitat for wetland-associated birds. Thus, there is a concern that birds may be attracted to potentially toxic habitats. This study assesses nesting success and forging behavior of Red-winged Blackbirds (Agelaius phoeniceus) in retention stormwater wetlands based on drainage type. Drainage categories included residential, commercial, and highway sites. Commercial sites had the lowest nesting success and the lowest diversity of invertebrate foods. Mean nest success values for all three types of wetlands, especially for highway drainages, were comparable to published values from natural wetlands. Over two years of study highway ponds collectively served as source populations whereas residential and commercial sites were population sinks in one year and sources in the other. Red-wings using highway sites had the highest foraging efficiency as determined by the frequency and duration of forays. Residential sites had the greatest human disturbance and generally had intermediate-quality habitat and nesting success. We conclude that while stormwater wetlands collect run off and accompanying pollutants, they can still be valuable habitats for nesting birds in urban and suburban areas. We recommend a few management strategies that can increase avian use of these habitats. ?? Springer Science+Business Media, LLC 2007.

Managing a Safe and Successful Multi-User Spaceport

NASA Technical Reports Server (NTRS)

Dacko, Taylor; Ketterer, Kirk; Meade, Phillip

2016-01-01

Encouraged by the creation of the Office of Commercial Space Transportation within the U.S. Federal Aviation Administration (FAA) in 1984 and the Commercial Space Act of 1998, the National Aeronautics and Space Administration (NASA) now relies on an extensive network of support from commercial companies and organizations. At NASA's Kennedy Space Center (KSC), this collaboration opens competitive opportunities for launch providers, including repurposing underutilized Shuttle Program resources, constructing new facilities, and utilizing center services and laboratories. The resulting multi-user spaceport fosters diverse activity, though it engenders risk from hazards associated with various spaceflight processing activities. The KSC Safety & Mission Assurance (S&MA) Directorate, in coordination with the center's Spaceport Integration and Center Planning & Development organizations, has developed a novel approach to protect NASA's workforce, critical assets, and the public from hazardous, space-related activity associated with KSC's multi-user spaceport. For NASA KSC S&MA, the transformation to a multi-user spaceport required implementing methods to foster safe and successful commercial activity while resolving challenges involving: Retirement of the Space Shuttle program; Co-location of multiple NASA programs; Relationships between the NASA programs; Complex relationships between NASA programs and commercial partner operations in exclusive-use facilities; Complex relationships between NASA programs and commercial partner operations in shared-use facilities. NASA KSC S&MA challenges were met with long-term planning and solutions involving cooperation with the Spaceport Integration and Services Directorate. This directorate is responsible for managing active commercial partnerships with customer advocacy and services management, providing a dedicated and consistent level of support to a wide array of commercial operations. This paper explores these solutions, their relevance to the current commercial space industry, and the challenges that continue to drive improvement with a focus on areas of safety management and risk assessment that have been crucial in KSC's evolution into a multi-user spaceport. These solutions may be useful to government entities and private companies looking to partner with the commercial space industry.

U.S. commercial space policies - Implications for developing countries

NASA Technical Reports Server (NTRS)

Gillam, Isaac T., IV; Stone, Barbara A.

1987-01-01

Recent U.S. policy developments on the commercial use of space are summarized and their international implications are considered. Attention is given to successful applications of technology developed in space, including an implantable cancer medication system, an implantable defibrillator, an ultrasonic residual stress monitor, and aquaculture treatment techniques. NASA projects involving bioengineering and rehabilitation applications are summarized, and plans to investigate high-temperature superconductors in space are addressed. Recent agreements entred into by NASA for space commercial studies are reviewed.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gallaspy, D.T.

The purpose of this paper is to propose Asia as a focus market for commercialization of CCT`s; describe the principles for successful penetration of CCT`s in the international market; and summarize prospects for CCT`s in Asia and other international markets. The paper outlines the following: Southern Company`s clean coal commitment; acquisition of Consolidated Electric Power Asia (CEPA); the prospects for CCT`s internationally; requirements for CCT`s widespread commercialization; CEPA`s application of CCT`s; and gas turbine power plants as a perfect example of a commercialization driver.

Evaluation of single nucleotide polymorphisms in chromosomal regions impacting pregnancy status in cattle

USDA-ARS?s Scientific Manuscript database

Reproductive success is an important component of commercial beef cattle production, and identification of DNA markers with predictive merit for reproductive success would facilitate accurate prediction of mean daughter pregnancy rate, enabling effective selection of bulls to improve female fertilit...

Key factors of case management interventions for frequent users of healthcare services: a thematic analysis review.

PubMed

Hudon, Catherine; Chouinard, Maud-Christine; Lambert, Mireille; Diadiou, Fatoumata; Bouliane, Danielle; Beaudin, Jérémie

2017-10-22

The aim of this paper was to identify the key factors of case management (CM) interventions among frequent users of healthcare services found in empirical studies of effectiveness. Thematic analysis review of CM studies. We built on a previously published review that aimed to report the effectiveness of CM interventions for frequent users of healthcare services, using the Medline, Scopus and CINAHL databases covering the January 2004-December 2015 period, then updated to July 2017, with the keywords 'CM' and 'frequent use'. We extracted factors of successful (n=7) and unsuccessful (n=6) CM interventions and conducted a mixed thematic analysis to synthesise findings. Chaudoir's implementation of health innovations framework was used to organise results into four broad levels of factors: (1) ,environmental/organisational level, (2) practitioner level, (3) patient level and (4) programme level. Access to, and close partnerships with, healthcare providers and community services resources were key factors of successful CM interventions that should target patients with the greatest needs and promote frequent contacts with the healthcare team. The selection and training of the case manager was also an important factor to foster patient engagement in CM. Coordination of care, self-management support and assistance with care navigation were key CM activities. The main issues reported by unsuccessful CM interventions were problems with case finding or lack of care integration. CM interventions for frequent users of healthcare services should ensure adequate case finding processes, rigorous selection and training of the case manager, sufficient intensity of the intervention, as well as good care integration among all partners. Other studies could further evaluate the influence of contextual factors on intervention impacts. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Distraction systems for ankle arthroscopy.

PubMed

Palladino, S J

1994-07-01

It is clear that for most of the routine pathology addressed with ankle arthroscopy, including most talar dome transchondral fractures, manual distraction (or none at all) is all that is necessary to successfully complete the procedure. There is little need to add the expense and potential complications associated with some distraction systems. However, some cases involve pathology or surgical techniques that either would be better addressed with distraction or absolutely demand distraction. It is recommended that invasive ankle distraction be reserved for (1) cases in which noninvasive distraction has not yielded adequate field visualization or instrument maneuvering room, (2) cases of preoperatively documented pathology involving the posterior talar dome (including some medial talar dome fractures) or inferior tibial surface, or (3) arthroscopic ankle fusion. Consideration should be given to providing 6 to 12 weeks of protected function of the extremity to avoid delayed fracture presentation. In general, the invasive distraction system should be reserved for those cases that would not ordinarily be managed with aggressive rehabilitation and early return to activities. For those cases where the benefits of distraction are desired (some dome fractures, meniscoid lesions, gutter pathology, and adhesive capsulitis) and aggressive rehabilitation with early return to activities may be planned, noninvasive distraction systems are now available that offer a sustainable joint separation of good magnitude. With the growing availability and effectiveness of the commercial noninvasive ankle distractors, I do not disagree with Stone and Guhl98 when they advocate the use of noninvasive distraction for routine arthroscopic procedures, with conversion to invasive distraction should there be insufficient joint separation. In summary, providing optimal field visualization and maneuvering room for instrumentation is essential for the successful performance of arthroscopic ankle surgery. This article has discussed options available to the arthroscopist that can assist in achieving these objectives. The exact method of distraction selected for a given case may be determined by the arthroscopist by weighing the issues discussed in this article.

The path to successful commercialization of cell and gene therapies: empowering patient advocates.

PubMed

Bauer, Gerhard; Abou-El-Enein, Mohamed; Kent, Alastair; Poole, Brian; Forte, Miguel

2017-02-01

Often, novel gene and cell therapies provide hope for many people living with incurable diseases. To facilitate and accelerate a successful regulatory approval and commercialization path for effective, safe and affordable cell and gene therapies, the involvement of patient advocacy groups (PAGs) should be considered early in the development process. This report provides a thorough overview of the various roles PAGs play in the clinical translation of cell and gene therapies and how they can bring about positive changes in the regulatory process, infrastructure improvements and market stability. Copyright © 2017 International Society for Cellular Therapy. Published by Elsevier Inc. All rights reserved.

Tendon Tissue Engineering: Progress, Challenges, and Translation to the Clinic

PubMed Central

Shearn, Jason T.; Kinneberg, Kirsten R.C.; Dyment, Nathaniel A.; Galloway, Marc T.; Kenter, Keith; Wylie, Christopher; Butler, David L.

2013-01-01

The tissue engineering field has made great strides in understanding how different aspects of tissue engineered constructs (TECs) and the culture process affect final tendon repair. However, there remain significant challenges in developing strategies that will lead to a clinically effective and commercially successful product. In an effort to increase repair quality, a better understanding of normal development, and how it differs from adult tendon healing, may provide strategies to improve tissue engineering. As tendon tissue engineering continues to improve, the field needs to employ more clinically relevant models of tendon injury such as degenerative tendons. We need to translate successes to larger animal models to begin exploring the clinical implications of our treatments. By advancing the models used to validate our TECs, we can help convince our toughest customer, the surgeon, that our products will be clinically efficacious. As we address these challenges in musculoskeletal tissue engineering, the field still needs to address the commercialization of products developed in the laboratory. TEC commercialization faces numerous challenges because each injury and patient is unique. This review aims to provide tissue engineers with a summary of important issues related to engineering tendon repairs and potential strategies for producing clinically successful products. PMID:21625053

NASA's Commercial Space Centers: Bringing Together Government and Industry for "Out of this World" Benefits

NASA Technical Reports Server (NTRS)

Robinson, R. Keith; Henderson, Robin N. (Technical Monitor)

2002-01-01

The National Aeronautics and Space Administration (NASA) is making significant effort to accommodate commercial research in the utilization plans of the International Space Station (ISS)[1]. NASA is providing 30% of the research accommodations in the ISS laboratory modules to support commercial endeavors. However, the availability of resources alone does not necessarily translate into significant private sector participation in NASA's ISS utilization plans. Due to the efforts of NASA's Commercial Space Centers (CSC's), NASA has developed a very robust plan for involving the private sector in ISS utilization activities. Obtaining participation from the private sector requires a demonstrated capability for obtaining commercially significant research results. Since 1985, NASA CSC's have conducted over 200 commercial research activities aboard parabolic aircraft, sounding rockets, the Space Shuttle, and the ISS. The success of these activities has developed substantial investment from private sector companies in commercial space research.

Whales, science, and scientific whaling in the International Court of Justice.

PubMed

Mangel, Marc

2016-12-20

I provide a brief review of the origins of the International Convention on the Regulation of Whaling and the failure to successfully regulate whaling that led to the commercial moratorium in 1986. I then describe the Japanese Whale Research Programs Under Special Permit in the Antarctica (JARPA I, JARPA II) and the origins of the case Whaling in the Antarctic (Australia v. Japan: New Zealand Intervening) in the International Court of Justice. I explain that the International Court of Justice chose to conduct an objective review of JARPA II, the standard that it used for the review, and the pathway that it took to adjudicate the case without providing a definition of science to be used in international law. I conclude with a brief discussion of the implications of the Judgment for the International Convention on the Regulation of Whaling, and the International Whaling Commission in particular, for other international treaties, and for the interaction of science and law more generally.

Efficacy of oral vancomycin in recurrent primary sclerosing cholangitis following liver transplantation.

PubMed

Hey, Penelope; Lokan, Julie; Johnson, Paul; Gow, Paul

2017-09-25

Primary sclerosing cholangitis (PSC) is a liver disease that leads to progressive destruction and stricturing of the biliary tree. Unfortunately, apart from orthotopic liver transplantation (OLT), there are no universally accepted therapies to treat this disease. Even following transplantation, recurrence of PSC is seen in approximately one quarter of patients and leads to high rates of graft failure. Oral vancomycin, through possible immunomodulatory and anti-inflammatory mechanisms, has been shown in small-scale studies to be successful in improving liver function tests in patients with pretransplant PSC. We report the first case of an adult patient diagnosed with recurrent PSC 4 years after OLT who was treated with oral vancomycin leading to complete normalisation of his liver biochemistry. This case adds to the growing literature of a potential therapeutic role for this antibiotic in PSC and highlights interesting questions regarding mechanisms of disease. © BMJ Publishing Group Ltd (unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

In-flight automated external defibrillator use and consultation patterns.

PubMed

Brown, Aaron Michael; Rittenberger, Jon C; Ammon, Charles M; Harrington, Scott; Guyette, Francis X

2010-01-01

Limited information exists about the in-flight use and outcomes associated with automated external defibrillators (AEDs) on commercial airlines. To describe the characteristics and outcomes of AED use during in-flight emergencies including in-flight cardiac arrest and the associated ground medical consultation patterns. We collected cases of AED use that were self-reported to an airline consultation service from three U.S. airlines between May 2004 and March 2009. We reviewed all available data files, related consultation forms, and recordings. For each case, demographics, initial rhythm, shock delivery/success, survival to admission, and ground medical consultation use were obtained. Success was defined as the return of a perfusing rhythm. Initial rhythms were classified as sinus, heart block, supraventricular tachycardia (SVT), atrial fibrillation/flutter, asystole, pulseless electrical activity (PEA), and ventricular fibrillation (VF)/ventricular tachycardia (VT). There were a total of 169 AED applications with 40 cardiac arrests. The mean patient ages were 58 years (standard deviation [SD] 15) and 63 years (SD 12), respectively; both populations were 64% male. AEDs were applied for monitoring in 129 (76%) cases with the following initial rhythms: sinus, 114 (88%); atrial fibrillation/flutter, seven (5%); complete heart block, four (3%); and SVT, four (3%). Presenting rhythms among the cardiac arrest population were as follows: asystole, 16 (40%); VF/VT, 10 (25%); and PEA, 14 (35%). Fourteen patients were defibrillated, including nine of the 10 patients with initial VF/VT and five for the presence of VF/VT after resuscitation for initial PEA/asystole. Defibrillation was advised but not performed in the remaining case of initial VF/VT, and no medical consultation was obtained. All five successful defibrillations occurred in patients with initial VF/VT. There were six (15%; 95% confidence interval [CI] 3-27%) survivors, with five survivals occurring after successful defibrillation for initial VF/VT and one with return of a perfusing rhythm after cardiopulmonary resuscitation (CPR) for a junctional rhythm. Survival in those with VF/VT was five of 10 (50%; 95% CI 14-86%). Medications were delivered in two cases. The median time to first shock was 19 seconds (interquartile range [IQR] 12-24 seconds) after AED application. Medical consultation was obtained in 42 (33%) of the 129 AED monitoring cases and 14 (35%) of the 40 cardiac arrest cases. Use of AEDs resulted in 50% survival among those with VF/VT in flight and 15% overall survival for cardiac arrest. Survival is poor among patients presenting with nonshockable rhythms. AEDs are used extensively for in-flight monitoring, with significant rhythms identified. Ground medical consultation is sought in only one-third of AED uses and cardiac arrests.

ARPA-E: Guiding Technologies to Commercial Success

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tuttle, John; Aizenberg, Joanna; Madrone, Leila

ARPA-E’s Technology-to-Market Advisors work closely with each ARPA-E project team to develop and execute a commercialization strategy. ARPA-E requires our teams to focus on their commercial path forward, because we understand that to have an impact on our energy mission, technologies must have a viable path into the marketplace. ARPA-E Senior Commercialization Advisor Dr. John Tuttle discusses what this Tech-to-Market guidance in practice looks like with reference to two project teams. OPEN 2012 awardees from Harvard University and Sunfolding share their stories of how ARPA-E worked with their teams to analyze market conditions and identify commercial opportunities that ultimately convincedmore » them to pivot their technologies towards market applications with greater potential.« less

A Pragmatic Study on the Functions of Vague Language in Commercial Advertising

ERIC Educational Resources Information Center

Wenzhong, Zhu; Jingyi, Li

2013-01-01

Vagueness is one of the basic attributes of natural language. This is the same to advertising language. Vague language is a subject of increasing interest, and both foreign and domestic studies have attained success in it. Nevertheless, the study on the application of vague language in the context of English commercial advertising is relatively…

Cost Effectiveness of Natural Regeneration for Sustaining Production Continuity in Commercial Pine Plantations

Treesearch

T.R. Clason

2002-01-01

Reforestation is a key to production continuity in commercial pine plantations. Although natural and artificial regeneration methods have been used successfully for pine seedling establishment, it is seedling growth during early stage of plantation development that affects the financial potential of a pine plantation. A study was initiated to determine the effect of...

Chapter 25. Shrub and forb seed production

Treesearch

Gordon A. Van Epps; Richard Stevens

2004-01-01

The success or failure of range restoration and revegetation programs depends on procurement of an adequate supply of quality grass, forb, and shrub seed. Rangeland species seed is either grown commercially or collected from wildland stands. Commercially produced seed of numerous grass species is available (Asay and Knowles 1985b; Horton and others 1990; Sours 1983). A...

Putting School Commercialism in Context: A Global History of Junior Achievement Worldwide

ERIC Educational Resources Information Center

Sukarieh, Mayssoun; Tannock, Stuart

2009-01-01

The literature on school commercialism, despite a number of successes in battling advertising and marketing in schools, has often seemed to only scratch the surface of corporatization of K-12 education. While condemning corporations who seek to sell brand-name products to kids in schools is a relatively straightforward matter, critiquing corporate…

1994 Technology Applications Report

DTIC Science & Technology

1994-01-01

A Sunny Commercial Success Story 46 ■ Cleaner Battery To Provide Power For Global Communications 47 ■ Carbon Aerogels Empower Commercial Uses 48...identify certain characteristics, such as chemical composition or atomic energy levels. Researchers at IUSL (pictured above) have been using this...the composition , tem- perature, concen- tration, and dimen- sions of specific substances. Researchers at AFR recognized that the technology

Financial issues for commercial space ventures: Paying for the dreams

NASA Technical Reports Server (NTRS)

Egan, J. J.

1984-01-01

Various financial issues involved in commercial space enterprise are discussed. Particular emphasis is placed on the materials processing area: the current state of business plan and financial developments, what is needed for enhanced probability of success of future materials development efforts in attracting financial backing, and finally, the risks involved in this entire business area.

Integrating knowledge based functionality in commercial hospital information systems.

PubMed

Müller, M L; Ganslandt, T; Eich, H P; Lang, K; Ohmann, C; Prokosch, H U

2000-01-01

Successful integration of knowledge-based functions in the electronic patient record depends on direct and context-sensitive accessibility and availability to clinicians and must suit their workflow. In this paper we describe an exemplary integration of an existing standalone scoring system for acute abdominal pain into two different commercial hospital information systems using Java/Corba technolgy.

Measuring Vitamin C Content of Commercial Orange Juice Using a Pencil Lead Electrode

ERIC Educational Resources Information Center

King, David; Friend, Jeffrey; Kariuki, James

2010-01-01

A pencil lead successfully served as an electrode for the determination of ascorbic acid in commercial orange juice. Cyclic voltammetry was used as an electrochemical probe to measure the current produced from the oxidation of ascorbic acid with a variety of electrodes. The data demonstrate that the less expensive pencil lead electrode gives…

First Year Evaluation of the Mathematics Pilot Programs, Grades K-8, [and] Appendices. Evaluation Department Report No. 381.

ERIC Educational Resources Information Center

Tomblin, Elizabeth A.; And Others

The San Diego Board of Education requested that pilot programs be conducted with commercially developed (Grades K-8) mathematics textbooks and programs in order to determine which of the programs/texts were superior, and whether a district-developed program could successfully compete with commercially produced materials. The pilot program…

Is Privacy at Risk when Commercial Websites Target Primary School Children? A Case Study in Korea

ERIC Educational Resources Information Center

Kim, Sora; Yi, Soon-Hyung

2010-01-01

This study discusses privacy risk factors when commercial web sites target primary school children in Korea. Specifically, the authors examined types of personal information required for membership subscriptions and whether privacy policies at commercial sites for children abide by privacy guidelines. A total of 159 commercial sites targeting…

Spinoff 2001: Special Millennium Feature

NASA Technical Reports Server (NTRS)

2001-01-01

For the past 43 years, NASA has devoted its facilities, labor force, and expertise to sharing the abundance of technology developments used for its missions with the nation's industries. These countless technologies have not only successfully contributed to the growth of the U.S. economy, but also to the quality of life on Earth. For the past 25 years, NASA's Spinoff publication has brought attention to thousands of technologies, products, and services that were developed as a direct result of commercial partnerships between NASA and the private business sector. Many of these exciting technologies included advances in ceramics, computer technology, fiber optics, and remote sensing. New and ongoing research at the NASA field centers covers a full spectrum of technologies that will provide numerous advantages for the future, many of which have made significant strides in the commercial market. The NASA Commercial Technology Network plays a large role in transferring this progress. By applying NASA technologies such as data communication, aircraft de-icing technologies, and innovative materials to everyday functions, American consumers and the national economy benefit. Moving forward into the new millennium, these new technologies will further advance our country's position as the world leader in scientific and technical innovation. These cutting-edge innovations represent the investment of the U.S. citizen in the Space Program. Some of these technologies are highlighted in Spinoff 2001, an example of NASA's commitment to technology transfer and commercialization assistance. This year's issue spotlights the commercial technology efforts of NASA's John F. Kennedy Space Center. Kennedy's extensive network of commercial technology opportunities has enabled them to become a leader in technology transfer outreach. This kind of leadership is exemplified through Kennedy's recent partnership with the State of Florida, working toward the development of the Space Experiment Research and Processing Laboratory. The new laboratory is the first step toward the development of a proposed 400-acre Space Commerce Park, located at Kennedy Space Center. Spinoff, once again, successfully showcases the variety of commercial successes and benefits resulting from the transfer of NASA technology to private industry. It is with great pride and pleasure that we present Spinoff 2001 with a Special Millennium Feature. With help from U.S. industry and commercial technology programs, NASA will continue to assist in the presentation of innovative new products to our nation.

8 CFR 204.6 - Petitions for employment creation aliens.

Code of Federal Regulations, 2010 CFR

2010-01-01

... the new commercial enterprise. In the case of the Immigrant Investor Pilot Program, “employee” also... position that requires a minimum of 35 working hours per week. In the case of the Immigrant Investor Pilot... States dollars ($1,000,000). (g) Multiple investors—(1) General. The establishment of a new commercial...

Commercial flight and patients with intracranial mass lesions: a caveat. Report of two cases.

PubMed

Zrinzo, Ludvic U; Crocker, Matthew; Zrinzo, Laurence V; Thomas, David G T; Watkins, Laurence

2006-10-01

The authors report two cases of neurological deterioration following long commercial flights. Both individuals harbored intracranial space-occupying lesions. The authors assert that preexisting reduced intracranial compliance diminishes an individual's reserve to accommodate the physiological changes resulting from a commercial flight. Airline passengers are exposed to a mild degree of hypercapnia as well as conditions that simulate those of high-altitude ascents. High-altitude cerebral edema following an ascent to great heights is one facet of acute mountain sickness and can be life threatening in conditions similar to those present on commercial flights. Comparable reports documenting neurological deterioration at high altitudes in patients with coexisting space-occupying lesions were also reviewed.

The neurosurgeon as innovator and entrepreneur.

PubMed

Firlik, A D; Lowry, D W; Levy, A J; Hirsch, R C

2000-07-01

INNOVATION IS THE driving force behind progress in neurosurgery. Most significant innovations require commercialization to ensure appropriate development and ultimate distribution to patients. There are several key factors that determine whether a particular innovation is likely to be commercially successful. Relationships between academic neurosurgeons and industry are likely to increase in the future. Stronger and more productive relationships between academic neurosurgeons and commercial ventures will provide new opportunities for neurosurgeons to bring innovations to patients more effectively and efficiently. The transfer of innovation from the academic environment to the commercial setting is consistent with the academic mission and can increase funding for basic and clinical neuroscience research.

A perspective on early commercial applications of voice-processing technology for telecommunications and aids for the handicapped.

PubMed Central

Seelbach, C

1995-01-01

The Colloquium on Human-Machine Communication by Voice highlighted the global technical community's focus on the problems and promise of voice-processing technology, particularly, speech recognition and speech synthesis. Clearly, there are many areas in both the research and development of these technologies that can be advanced significantly. However, it is also true that there are many applications of these technologies that are capable of commercialization now. Early successful commercialization of new technology is vital to ensure continuing interest in its development. This paper addresses efforts to commercialize speech technologies in two markets: telecommunications and aids for the handicapped. PMID:7479814

India Commercial Buildings Data Framework: A Summary of Potential Use Cases

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mathew, Paul; Mathew, Sangeeta; Kumar, Satish

This report details a potential set of use cases for India’s Commercial Buildings Data Framework. The use cases are aimed at enabling data-driven, evidence-based policy making and at transforming the market for energy efficiency in the building sector by facilitating the adoption of (1) superior energy-efficient building design and operation and maintenance practices, and (2) better specification and procurement of end-use equipment and systems.

Fuel cell commercialization — beyond the 'Notice of Market Opportunity for Fuel Cells' (NOMO)

NASA Astrophysics Data System (ADS)

Serfass, J. A.; Glenn, D. R.

1992-01-01

The Notice of Market Opportunity for Fuel Cells (NOMO) was released in Oct. 1988 by the American Public Power Association. Its goal was to identify a manufacturer for commercializing a multi-megawatt fuel cell power plant with attractive cost and performance characteristics, supported by a realistic, yet aggressive commercialization plan, leading to mid-1990s application. Energy Research Corporation's program to commercialize its 2-MW internal-reforming carbonate fuel cell was selected. The program was refined in the development of the Principles and Framework for Commercializing Direct Fuel Cell Power Plants, which defines buyer responsibilities for promotion and coordination of information development, supplier responsibilities for meeting certain milestones and for sharing the results of success in a royalty agreement, and risk management features. Twenty-three electric and gas utilities in the US and Canada have joined the Fuel Cell Commercialization Group to support the buyers' obligations in this program. The City of Santa Clara, CA; Electric Power Research Institute; Los Angeles Department of Water and Power; Southern California Gas Company; Southern California Edison; National Rural Electric Cooperative Association; and Pacific Gas & Electric, have formed the Santa Clara Demonstration Group to build the first 2-MW power plant. The preliminary design for this demonstration is nearly complete. Integrated testing of a 20-kW stack with the complete balance-of-plant, has been successfully accomplished by Pacific Gas & Electric at its test facility in San Ramon, CA.

Using administrative claims to identify children with chronic conditions in a statewide immunization registry.

PubMed

Dombkowski, Kevin J; Costello, Lauren; Dong, Shiming; Clark, Sarah J

2014-05-01

To demonstrate the feasibility and utility of using administrative claims data from commercial health plans to establish a high-risk indicator in a statewide immunization registry for enrollees with chronic conditions. Retrospective cohort analysis. Administrative data were used to identify children with 1 or more chronic conditions enrolled in 2 commercial health plans during the 2008-2009 and 2009-2010 influenza seasons and matched with a statewide immunization registry. The proportion of cases that successfully matched and historical health services utilization, including influenza vaccinations and missed opportunities, were assessed. A total of 93% of children with chronic conditions identified through administrative claims were successfully matched with the statewide registry. Less than one-third of children received the seasonal influenza vaccine in either the 2008-2009 (29%) or 2009-2010 (32%) seasons; 30% of children received the H1N1 vaccination in 2009-2010. Most children in the 2008-2009 (63%) and 2009-2010 (63%) seasons had at least 1 missed opportunity for seasonal influenza vaccination. Younger children had the highest percentage of missed opportunities while adolescents had the lowest rate of missed opportunities for vaccination. Conclusions It is feasible to identify children with chronic conditions using administrative data and to link them with a statewide immunization registry. Low influenza vaccination rates and high occurrences of missed opportunities among children with chronic conditions suggest the utility of integrating administrative claims data with statewide registries to support various outreach mechanisms, including physician-focused and parent-targeted reminder/recall, based on target age to improve vaccination rates.

Performance Analysis of a Cost-Effective Electret Condenser Microphone Directional Array

NASA Technical Reports Server (NTRS)

Humphreys, William M., Jr.; Gerhold, Carl H.; Zuckerwar, Allan J.; Herring, Gregory C.; Bartram, Scott M.

2003-01-01

Microphone directional array technology continues to be a critical part of the overall instrumentation suite for experimental aeroacoustics. Unfortunately, high sensor cost remains one of the limiting factors in the construction of very high-density arrays (i.e., arrays containing several hundred channels or more) which could be used to implement advanced beamforming algorithms. In an effort to reduce the implementation cost of such arrays, the authors have undertaken a systematic performance analysis of a prototype 35-microphone array populated with commercial electret condenser microphones. An ensemble of microphones coupling commercially available electret cartridges with passive signal conditioning circuitry was fabricated for use with the Langley Large Aperture Directional Array (LADA). A performance analysis consisting of three phases was then performed: (1) characterize the acoustic response of the microphones via laboratory testing and calibration, (2) evaluate the beamforming capability of the electret-based LADA using a series of independently controlled point sources in an anechoic environment, and (3) demonstrate the utility of an electret-based directional array in a real-world application, in this case a cold flow jet operating at high subsonic velocities. The results of the investigation revealed a microphone frequency response suitable for directional array use over a range of 250 Hz - 40 kHz, a successful beamforming evaluation using the electret-populated LADA to measure simple point sources at frequencies up to 20 kHz, and a successful demonstration using the array to measure noise generated by the cold flow jet. This paper presents an overview of the tests conducted along with sample data obtained from those tests.

NREL Success Stories - Quest for Inexpensive Silicon Solar Cells

ScienceCinema

Branz, Howard

2017-12-09

Scientists at the National Renewable Energy Laboratory (NREL) share their story about a successful partnership with Oak Ridge National Laboratory and the Ampulse Corporation and how support from the US Department of Energy's Technology Commercialization & Deployment Fund has helped it and their silicon solar cell research thrive.

LANDSAT menhaden and thread herring resources investigation, Gulf of Mexico

NASA Technical Reports Server (NTRS)

Savastano, K. (Principal Investigator); Kemmerer, A. J.; Leming, T.; Holley, H.; Faller, K. H.

1977-01-01

The author has identified the following significant results. The most significant achievement thus far includes the successful charting of high probability fishing areas from LANDSAT MSS data and the successful simulation of an operational satellite system to provide tactical information for the commercial harvest of menhaden.

LANDSAT menhaden and thread herring resources investigation, Gulf of Mexico

NASA Technical Reports Server (NTRS)

Savastano, K. (Principal Investigator); Kemmerer, A. J.; Leming, T.; Holley, H.; Faller, K. H.

1976-01-01

The author has identified the following significant results. The most significant achievements thus far include the successful charting of high probability fishing areas from LANDSAT MSS data and the successful simulation of an operational satellite system to provide tactical information for the commercial harvest of menhaden.

Success Stories | NCI Technology Transfer Center | TTC

Cancer.gov

NIH’s world-class facilities, resources, and discoveries. Some of our partnerships have resulted in the commercialization of therapeutics, vaccines, diagnostics, medical devices and research tools that benefit patients worldwide. TTC is proud to share a few examples of our successful partnerships. | [google6f4cd5334ac394ab.html

Beyond Yellow Curry: Assessing Commercial Curcumin Absorption Technologies.

PubMed

Douglass, Brad J; Clouatre, Dallas L

2015-01-01

Few natural products have demonstrated the range of protective and therapeutic promise as have turmeric and its principal bioactive components: curcumin, demethoxycurcumin, and bisdemethoxycurcumin. Success in translating this potential into tangible benefits has been limited by inherently poor intestinal absorption, rapid metabolism, and limited systemic bioavailability. Seeking to overcome these limitations, food ingredient formulators have begun to employ a variety of approaches to enhance absorption and bioactivity. Many of these strategies improve upon the age-old practice of consuming turmeric in fat-based sauces, such as in a fat-rich yellow curry. However, there exists uncertainty as to how the various commercially available offerings compare to each other in terms of either uptake or efficacy, and this uncertainty leaves physicians and nutritionists with a dearth of data for making recommendations to interested patients and consumers. Further complicating the issue are recent data suggesting that formulation strategies may not equally enhance the absorption of individual curcuminoids, a significant issue in that these curcuminoids exhibit somewhat different physiologic properties. This review introduces needed order to the curcumin marketplace by examining bioavailability studies on a number of commercial curcumin ingredients and evaluating them on a level playing field. The comparative analysis includes standard pharmacokinetic parameters and a new metric, relative mass efficiency (E). Relative mass efficiency allows for the comparison of different formulations even in cases in which the weight percentage of curcuminoids is vastly different. A hydrophilic carrier dispersed curcuminoid formula exhibits 45.9 times the bioavailability of the standard purified 95 percent curcuminoid preparation and, based on relative mass efficiency, 1.5 times the bioavailability of the next best commercial ingredient, a cyclodextrin complex. Delivery strategies can significantly improve the bioavailability of curcuminoids. Total formula mass is important for making practical formulation decisions about dosing, cost and space.

Commercial vehicle fleet management and information systems. Technical memorandum 2 : summary of case study interviews

DOT National Transportation Integrated Search

1997-10-01

The FHWA has commissioned the Commercial Vehicle Fleet Management and Information Systems study to determine if there are fleet management needs that the public sector can address through the development of ITS for commercial vehicle operations. As p...

Malaria in tree crop plantations in south-eastern and western provinces of Thailand.

PubMed

Singhasivanon, P; Thimasarn, K; Yimsamran, S; Linthicum, K; Nualchawee, K; Dawreang, D; Kongrod, S; Premmanisakul, N; Maneeboonyang, W; Salazar, N

1999-09-01

During the past three decades almost half of the existing natural tropical forests in Thailand were destroyed and replaced by cash crops, rubber, coffee, fruit orchards (durian, rambutan, mangosteen) and other commercial plantations. In order to determine the proportion of malaria cases contracted from such commercial plantations, an epidemiological study was conducted between June 1996 to May 1997 in two districts, one in Pong Nam Ron, located in a south-eastern province near the Cambodian border and another in Sai Yok, in a western province along the Myanmar border. Data were collected by passive case detection from patients attending the existing malaria clinics and active case detection by monthly malariometric survey in selected villages. All malaria cases were thoroughly investigated and classified according to exposure to different ecotypes prior to onset of malaria symptoms in the preceding two weeks. Malaria cases acquired from commercial plantations accounted for 35.2% and 11.2% in Pong Nam Ron and in Sai Yok districts respectively. In such plantations, most of the malaria cases were contracted from fruit orchards and to a lesser extent from rubber and teak plantations. From this study it is evident that commercial plantations provide a significant site of malaria transmission in addition to the forest and foothills areas in Southeast Asia where efficient vectors such as An. dirus and An. minimus are prevalent and have adapted to such changed ecosystems.

Effect of dynamic temperature storage in retail display case on the quality and microbiota of packaged fresh-cut leafy greens

USDA-ARS?s Scientific Manuscript database

Commercial refrigeration equipment is projected to rise 5.2% annually to meet the consumer demand for fresh-cut produce items. The highly variable temperature conditions associated with storage of fresh-cuts in commercial open-refrigerated display cases dramatically affects the shelf-life and qualit...

Hydraulic Hybrid Parcel Delivery Truck Deployment, Testing & Demonstration

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gallo, Jean-Baptiste

2014-03-07

Although hydraulic hybrid systems have shown promise over the last few years, commercial deployment of these systems has primarily been limited to Class 8 refuse trucks. In 2005, the Hybrid Truck Users Forum initiated the Parcel Delivery Working Group including the largest parcel delivery fleets in North America. The goal of the working group was to evaluate and accelerate commercialization of hydraulic hybrid technology for parcel delivery vehicles. FedEx Ground, Purolator and United Parcel Service (UPS) took delivery of the world’s first commercially available hydraulic hybrid parcel delivery trucks in early 2012. The vehicle chassis includes a Parker Hannifin hydraulicmore » hybrid drive system, integrated and assembled by Freightliner Custom Chassis Corp., with a body installed by Morgan Olson. With funding from the U.S. Department of Energy, CALSTART and its project partners assessed the performance, reliability, maintainability and fleet acceptance of three pre-production Class 6 hydraulic hybrid parcel delivery vehicles using information and data from in-use data collection and on-road testing. This document reports on the deployment of these vehicles operated by FedEx Ground, Purolator and UPS. The results presented provide a comprehensive overview of the performance of commercial hydraulic hybrid vehicles in parcel delivery applications. This project also informs fleets and manufacturers on the overall performance of hydraulic hybrid vehicles, provides insights on how the technology can be both improved and more effectively used. The key findings and recommendations of this project fall into four major categories: -Performance, -Fleet deployment, -Maintenance, -Business case. Hydraulic hybrid technology is relatively new to the market, as commercial vehicles have been introduced only in the past few years in refuse and parcel delivery applications. Successful demonstration could pave the way for additional purchases of hydraulic hybrid vehicles throughout the trucking industry. By providing unbiased, third-party assessment of this “hybrid without batteries” technology, this report offers relevant, timely and valuable information to the industry.« less

Non-traditional Sensor Tasking for SSA: A Case Study

NASA Astrophysics Data System (ADS)

Herz, A.; Herz, E.; Center, K.; Martinez, I.; Favero, N.; Clark, C.; Therien, W.; Jeffries, M.

Industry has recognized that maintaining SSA of the orbital environment going forward is too challenging for the government alone. Consequently there are a significant number of commercial activities in various stages of development standing-up novel sensors and sensor networks to assist in SSA gathering and dissemination. Use of these systems will allow government and military operators to focus on the most sensitive space control issues while allocating routine or lower priority data gathering responsibility to the commercial side. The fact that there will be multiple (perhaps many) commercial sensor capabilities available in this new operational model begets a common access solution. Absent a central access point to assert data needs, optimized use of all commercial sensor resources is not possible and the opportunity for coordinated collections satisfying overarching SSA-elevating objectives is lost. Orbit Logic is maturing its Heimdall Web system - an architecture facilitating “data requestor” perspectives (allowing government operations centers to assert SSA data gathering objectives) and “sensor operator” perspectives (through which multiple sensors of varying phenomenology and capability are integrated via machine -machine interfaces). When requestors submit their needs, Heimdall’s planning engine determines tasking schedules across all sensors, optimizing their use via an SSA-specific figure-of-merit. ExoAnalytic was a key partner in refining the sensor operator interfaces, working with Orbit Logic through specific details of sensor tasking schedule delivery and the return of observation data. Scant preparation on both sides preceded several integration exercises (walk-then-run style), which culminated in successful demonstration of the ability to supply optimized schedules for routine public catalog data collection – then adapt sensor tasking schedules in real-time upon receipt of urgent data collection requests. This paper will provide a narrative of the joint integration process - detailing decision points, compromises, and results obtained on the road toward a set of interoperability standards for commercial sensor accommodation.

Analysis and characterization of the novel psychoactive drug 4-chloromethcathinone (clephedrone).

PubMed

Taschwer, Magdalena; Weiß, Jennifer A; Kunert, Olaf; Schmid, Martin G

2014-11-01

Novel psychoactive drugs, such as amphetamine-, cathinone-, benzofury- and tryptamine derivatives, gained high popularity on the global drug market in the last years. These drugs are sold via the Internet as for example "research chemicals", "room odorizers" or "lawn fertilizers" by different online suppliers. They are also known as "Legal Highs", among them, cathinone derivatives play an important role. Well known substituted cathinone derivatives are mephedrone, brephedrone and flephedrone. Since a couple of weeks, a chlorine substituted methcathinone derivative, namely clephedrone (4-chloromethcathinone), is commercially available via the Internet from www.deboralabs.com. The goal of this study was to confirm identity of this substance, which was done successfully by GC-MS and NMR. Since all cathinone derivatives are chiral, it was found out, whether the purchased sample was present as a racemic mixture. For this purpose, methods for enantioseparation by GC and CE were developed and applied successfully. In case of CE a chiral selector was added, whereas chiral separation with GC-MS was done indirectly, after derivatization of clephedrone with trifluoroacetyl-l-prolyl chloride. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

A scientific note on the comparison of airborne volatiles produced by commercial bumble bee (Bombus impatiens) and honey bee (Apis mellifera) colonies

USDA-ARS?s Scientific Manuscript database

Small hive beetles have been documented as being able to successfully invade commercial bumble bee colonies and find the hives through odors produced by the colonies. We tested the hypothesis that volatiles emanating from Bumble bee and Honeybee colonies were similar by collecting volatiles from wo...

Progress in chemical luminescence-based biosensors: A critical review.

PubMed

Roda, Aldo; Mirasoli, Mara; Michelini, Elisa; Di Fusco, Massimo; Zangheri, Martina; Cevenini, Luca; Roda, Barbara; Simoni, Patrizia

2016-02-15

Biosensors are a very active research field. They have the potential to lead to low-cost, rapid, sensitive, reproducible, and miniaturized bioanalytical devices, which exploit the high binding avidity and selectivity of biospecific binding molecules together with highly sensitive detection principles. Of the optical biosensors, those based on chemical luminescence detection (including chemiluminescence, bioluminescence, electrogenerated chemiluminescence, and thermochemiluminescence) are particularly attractive, due to their high-to-signal ratio and the simplicity of the required measurement equipment. Several biosensors based on chemical luminescence have been described for quantitative, and in some cases multiplex, analysis of organic molecules (such as hormones, drugs, pollutants), proteins, and nucleic acids. These exploit a variety of miniaturized analytical formats, such as microfluidics, microarrays, paper-based analytical devices, and whole-cell biosensors. Nevertheless, despite the high analytical performances described in the literature, the field of chemical luminescence biosensors has yet to demonstrate commercial success. This review presents the main recent advances in the field and discusses the approaches, challenges, and open issues, with the aim of stimulating a broader interest in developing chemical luminescence biosensors and improving their commercial exploitation. Copyright © 2015 Elsevier B.V. All rights reserved.

NASA Earth Science Partnerships - The Role and Value of Commercial and Non-Profit Partnerships with Government in the Earth Sciences

NASA Astrophysics Data System (ADS)

Favors, J.; Cauffman, S.; Ianson, E.; Kaye, J. A.; Friedl, L.; Green, D. S.; Lee, T. J.; Murphy, K. J.; Turner, W.

2017-12-01

NASA's Earth Science Division (ESD) seeks to develop a scientific understanding of the Earth as a dynamic, integrated system of diverse components that interact in complex ways - analogous to the human body. The Division approaches this goal through a coordinated series of satellite and airborne missions, sponsored basic and applied research, and technology development. Integral to this approach are strong collaborations and partnerships with a spectrum of organizations with technical and non-technical expertise. This presentation will focus on a new commercial and non-profit partnership effort being undertaken by ESD to integrate expertise unique to these sectors with expertise at NASA to jointly achieve what neither group could alone. Highlights will include case study examples of joint work with perspectives from both NASA and the partner, building interdisciplinary teams with diverse backgrounds but common goals (e.g., economics and Earth observations for valuing natural capital), partnership successes and challenges in the co-production of science and applications, utilizing partner networks to amplify project outcomes, and how involving partners in defining the project scope drives novel and unique scientific and decision-making questions to arise.

A simple solution to systematic errors in density determination by X-ray reflectivity: The XRR-density evaluation (XRR-DE) method

NASA Astrophysics Data System (ADS)

Bergese, P.; Bontempi, E.; Depero, L. E.

2006-10-01

X-ray reflectivity (XRR) is a non-destructive, accurate and fast technique for evaluating film density. Indeed, sample-goniometer alignment is a critical experimental factor and the overriding error source in XRR density determination. With commercial single-wavelength X-ray reflectometers, alignment is difficult to control and strongly depends on the operator. In the present work, the contribution of misalignment on density evaluation error is discussed, and a novel procedure (named XRR-density evaluation or XRR-DE method) to minimize the problem will be presented. The method allows to overcome the alignment step through the extrapolation of the correct density value from appropriate non-specular XRR data sets. This procedure is operator independent and suitable for commercial single-wavelength X-ray reflectometers. To test the XRR-DE method, single crystals of TiO 2 and SrTiO 3 were used. In both cases the determined densities differed from the nominal ones less than 5.5%. Thus, the XRR-DE method can be successfully applied to evaluate the density of thin films for which only optical reflectivity is today used. The advantage is that this method can be considered thickness independent.

Biotechnology and the transformation of vaccine innovation: The case of the hepatitis B vaccines 1968-2000.

PubMed

Huzair, Farah; Sturdy, Steve

2017-08-01

The approval, from 1986, of a series of recombinant hepatitis B vaccines was a landmark both in the growth of biotechnology and in the development of the vaccine innovation system. In this paper, we show how the early development of the hepatitis B vaccines was shaped by a political and economic context that newly favoured commercialisation of academic research, including the appropriation and management of intellectual property; we elucidate the contingent interests and motivations that led new biotechnology companies and established pharmaceutical businesses to invest in developing recombinant vaccines specifically against hepatitis B; and we show how these and other factors combined to make those vaccines an unexpected commercial success. Broadening the scope of our analysis to include not just North America and Europe but also low- and middle-income countries, we show how the development of the hepatitis B vaccines facilitated the emergence of a two-tier innovation system structured by tensions between the demands for commercial profitability on the one hand, and the expectation of public health benefit for low- and middle-income countries on the other. Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.

Commercializing a U.S. piezoceramic linear motor

NASA Astrophysics Data System (ADS)

Diehl, Rick W.

2000-06-01

A small low-cost piezoceramic linear motor has been developed in the US and is being commercialized by EDO Corporation, working with a leading motion control OEM and with a prominent US corporate research laboratory. First generation motor design has emphasized high displacement at up to 200mm per second velocity with 3.5 Newtons force with high resolution, short time constant and a 15 volt power supply at a cost of less than 100 dollars. Motor dimensions of 30 by 50 by 4 mm allow broad configuration choices, al hidden within the motion control slide. The EDO approach was to build on its core competence in high reliability electroceramic material engineering and production, and to use a strategy of back-integrating, or outsourcing of recent advances outside Edo in piezoceramics, while forward- integrating into specific emerging applications known intimately by the OEM in the market. The strategy provided design focus that has led to a cost-effective advance in 'solid-state actuation and control'. This is considered a classic case of successful industrial integration of an enabling technology across organizations in order to access the needed mix of technology for development of an innovative and competitive solution.

Industry perceptions of barriers to commercialization of regenerative medicine products in the UK.

PubMed

Plagnol, Anke C; Rowley, Emma; Martin, Paul; Livesey, Finbarr

2009-07-01

Regenerative medicine is an emerging field with the potential to provide widespread improvement in healthcare and patient wellbeing via the delivery of therapies that can restore, regenerate or repair damaged tissue. As an industry, it could significantly contribute to economic growth if products are successfully commercialized. However, to date, relatively few products have reached the market owing to a variety of barriers, including a lack of funding and regulatory hurdles. The present study analyzes industry perceptions of the barriers to commercialization that currently impede the success of the regenerative medicine industry in the UK. The analysis is based on 20 interviews with leading industrialists in the field. The study revealed that scientific research in regenerative medicine is thriving in the UK. Unfortunately, lack of access to capital, regulatory hurdles, lack of clinical evidence leading to problems with reimbursement, as well as the culture of the NHS do not provide a good environment for the commercialization of regenerative medicine products. Policy interventions, including increased translational government funding, a change in NHS and NICE organization and policies, and regulatory clarity, would likely improve the general outcomes for the regenerative medicine industry in the UK.

Managing design for manufacture and assembly in the development of MEMS-based products

NASA Astrophysics Data System (ADS)

Hsu, Hung-Yao; Narasimhan, Nachchinarkkinian; Hariz, Alex J.

2006-12-01

Design for manufacturability, assembly and reliability of MEMS products is being applied to a multitude of novel MEMS products to make up for the lack of "Standard Process for MEMS" concept. The latter has proved a major handicap in commercialization of MEMS devices when compared to integrated circuits products. Furthermore, an examination of recent engineering literature seems to suggest convergence towards the development of the design for manufacturability and reliability of MEMS products. This paper will highlight the advantages and disadvantages of conventional techniques that have been pursued up to this point to achieve commercialization of MEMS products, identify some of the problems slowing down development, and explore measures that could be taken to try to address those problems. Successful commercialization critically depends on packaging and assembly, manufacturability, and reliability for micro scale products. However, a methodology that appropriately shadows next generation knowledge management will undoubtedly address most of the critical problems that are hampering development of MEMS industries. Finally this paper will also identify contemporary issues that are challenging the industry in regards to product commercialization and will recommend appropriate measures based on knowledge flow to address those shortcomings and lay out plans to expedient and successful paths to market.

Moving Technologies from the Test Tube to Commercial Products

NASA Technical Reports Server (NTRS)

Bryant, Robert G.

2013-01-01

Successful technologies include objects, processes, and procedures that share a common theme; they are being used to generate new products that create economic growth. The foundation is the invention, but the invention is a small part of the overall effort. The pathway to success is understanding the competition, proper planning, record keeping, integrating a supply chain, understanding actual costs, intellectual property (IP), benchmarking, and timing. Additionally, there are obstacles that include financing, what to make, buy, and sell, and the division of labor i.e. recognizing who is best at what task. Over the past two decades, NASA Langley Research Center (LaRC) has developed several commercially available technologies. The approach to commercialization of three of these inventions; Langley Research Center-Soluble Imide (LaRC-SI, Imitec Inc.), the Thin Layer Unimorph Driver (THUNDER, FACE International), and the Macrofiber Composite (MFC, Smart Material Corp.) will be described, as well as some of the lessons learned from the process. What makes these three inventions interesting is that one was created in the laboratory; another was built using the previous invention as part of its process, and the last one was created by packaging commercial-off-the-shelf (COTS) materials thereby creating a new component.

Proceedings: pellet fuels conference

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1995-12-31

The conference brought together professionals from the process- engineered-fuels (PEF), utility, paper, plastics, and boiler industries. Although the last two decades have produced technical breakthroughs, efforts to advance PEF must now focus on increasing commercial breakthroughs. Successful commercialization will depend on increasing supplier, consumer, and regulator confidence and support by demonstrating the performance and value of PEF products. Speakers provided updates on how PEF technology is evolving with respect to technical, economic, and regulatory challenges. Actions critical toward full commercialization of PEF were then considered. Discussion groups addressed materials sourcing, fuel processing and transportation, combustion, and ash handling.

Commercial filming of prehospital patient care

PubMed Central

Godfrey, P D; Henning, J D

2007-01-01

Commercial filming of patients in the hospital and now the prehospital environment is becoming increasingly common. Television programmes that focus on medical emergencies with real footage of events remain highly successful and can make compelling viewing for both medical professionals and the general public alike. Recently several commentators have questioned the ethical aspects of filming in hospital emergency departments, and noted the lack of available evidence. This article reviews commercial filming and its impact in the prehospital environment and examines the ethical implications and current guidance in this unique setting. PMID:18029523

Commercial filming of prehospital patient care.

PubMed

Godfrey, P D; Henning, J D

2007-12-01

Commercial filming of patients in the hospital and now the prehospital environment is becoming increasingly common. Television programmes that focus on medical emergencies with real footage of events remain highly successful and can make compelling viewing for both medical professionals and the general public alike. Recently several commentators have questioned the ethical aspects of filming in hospital emergency departments, and noted the lack of available evidence. This article reviews commercial filming and its impact in the prehospital environment and examines the ethical implications and current guidance in this unique setting.

Trichinellosis surveillance - United States, 2002-2007.

PubMed

Kennedy, Erin D; Hall, Rebecca L; Montgomery, Susan P; Pyburn, David G; Jones, Jeffrey L

2009-12-04

Trichinellosis is a parasitic disease caused by roundworms of the Trichinella genus. Humans are incidental hosts who become infected after ingestion of raw or undercooked meat containing encysted larvae of Trichinella spp. Common signs and symptoms of trichinellosis include eosinophilia, abdominal pain, fever, periorbital edema, and myalgia. National surveillance has documented a decline in the reported incidence of trichinellosis in the United States since 1947, the first year nationwide data were collected systematically. The decreased incidence of trichinellosis has mirrored the decrease of Trichinella in commercial pork products as a result of changes in pork industry management standards and government regulations. In addition, an overall decrease has occurred in the number of cases of trichinellosis related to pork consumption. During 1997-2001, meats other than pork were the most common source of infection, and more cases were associated with home-raised pork than with store-bought pork. 2002-2007. Trichinellosis is a reportable disease in 48 states and has been a nationally notifiable disease since 1966. Cases are defined by clinical characteristics and the results of laboratory testing for evidence of Trichinella infection. States report cases to CDC through the National Notifiable Diseases Surveillance System. Reported cases are summarized weekly and yearly in MMWR. In addition, states are asked to submit a standardized case report form with supplementary case data to CDC's Division of Parasitic Diseases. During 2002-2007, a total of 66 cases of trichinellosis were reported to CDC. Those cases for which a supplementary case report form was not submitted or that did not meet the case definition were excluded from analysis. Of the 66 cases reported during 2002-2007, a total of 12 (18%) cases were excluded from analysis. Associated meat products were classified as either pork or meat products other than pork and were identified for 43 (80%) cases. Meat products other than pork were associated with 27 (50%) cases: 21 with bear meat, one with either bear or deer meat, one with cougar meat, one with deer meat, one with walrus or seal meat, and two with commercial beef. Pork was associated with 10 (19%) cases: seven with commercial pork, two with noncommercial pork, and one with an unspecified type of pork. Of the seven cases associated with consumption of commercial pork, five were linked to U.S. commercial pork, and two were attributed to pork ingested during travel in Asia. The two cases associated with noncommercial pork were attributed to wild boar meat; one case involved wild boar meat from a farm and the other wild boar meat from a farmers' market. Six patients reported consuming both pork and meat products other than pork, but the infected meat product could not be identified. The number of reported trichinellosis cases attributed to commercial pork consumption remains low. The greatest number of cases continues to be associated with consumption of meat other than pork, especially bear meat. For the incidence of trichinellosis in the United States to be reduced further, education regarding safe food preparation practices and prevention of trichinellosis should be targeted toward hunters and other consumers of wild game meat, especially bear.

Credit Enhancement Overview Guide

DOE Office of Scientific and Technical Information (OSTI.GOV)

Financing Solutions Working Group

2014-01-01

Provides considerations for state and local policymakers and energy efficiency program administrators designing and implementing successful credit enhancement strategies for residential and commercial buildings.

Plantform Bioreactor for Mass Micropropagation of Date Palm.

PubMed

Almusawi, Abdulminam H A; Sayegh, Abdullah J; Alshanaw, Ansam M S; Griffis, John L

2017-01-01

A novel protocol for the commercial production of date palm through micropropagation is presented. This protocol includes the use of a semisolid medium alternation or in combination with a temporary immersion system (TIS, Plantform bioreactor) in date palm micropropagation. The use of the Plantform bioreactor for date palm results in an improved multiplication rate, reduced micropropagation time, and improved weaning success. It also reduces the cost of saleable units and thus improves economic return for commercial micropropagation. The use of the Plantform bioreactor successfully addresses other hindrances that can occur during the scale-up of date palm micropropagation, including asynchrony of somatic embryos, limited maturation of somatic embryos, and highly variable germination frequencies of embryos.

Stakeholder requirements for commercially successful wave energy converter farms

DOE Office of Scientific and Technical Information (OSTI.GOV)

Babarit, Aurélien; Bull, Diana; Dykes, Katherine

2017-12-01

In this study, systems engineering techniques are applied to wave energy to identify and specify stakeholders' requirements for a commercially successful wave energy farm. The focus is on the continental scale utility market. Lifecycle stages and stakeholders are identified. Stakeholders' needs across the whole lifecycle of the wave energy farm are analyzed. A list of 33 stakeholder requirements are identified and specified. This list of requirements should serve as components of a technology performance level metric that could be used by investors and funding agencies to make informed decisions when allocating resources. It is hoped that the technology performance levelmore » metric will accelerate wave energy conversion technology convergence.« less

Second Generation Reusable Launch Vehicle Development and Global Competitiveness of US Space Transportation Industry: Critical Success Factors Assessment

NASA Technical Reports Server (NTRS)

Enyinda, Chris I.

2002-01-01

In response to the unrelenting call in both public and private sectors fora to reduce the high cost associated with space transportation, many innovative partially or fully RLV (Reusable Launch Vehicles) designs (X-34-37) were initiated. This call is directed at all levels of space missions including scientific, military, and commercial and all aspects of the missions such as nonrecurring development, manufacture, launch, and operations. According to Wertz, tbr over thirty years, the cost of space access has remained exceedingly high. The consensus in the popular press is that to decrease the current astronomical cost of access to space, more safer, reliable, and economically viable second generation RLVs (SGRLV) must be developed. Countries such as Brazil, India, Japan, and Israel are now gearing up to enter the global launch market with their own commercial space launch vehicles. NASA and the US space launch industry cannot afford to lag behind. Developing SGRLVs will immeasurably improve the US's space transportation capabilities by helping the US to regain the global commercial space markets while supporting the transportation capabilities of NASA's space missions, Developing the SGRLVs will provide affordable commercial space transportation that will assure the competitiveness of the US commercial space transportation industry in the 21st century. Commercial space launch systems are having difficulty obtaining financing because of the high cost and risk involved. Access to key financial markets is necessary for commercial space ventures. However, public sector programs in the form of tax incentives and credits, as well as loan guarantees are not yet available. The purpose of this paper is to stimulate discussion and assess the critical success factors germane for RLVs development and US global competitiveness.

Toxicity of naphthenic acid fraction components extracted from fresh and aged oil sands process-affected waters, and commercial naphthenic acid mixtures, to fathead minnow (Pimephales promelas) embryos.

PubMed

Marentette, Julie R; Frank, Richard A; Bartlett, Adrienne J; Gillis, Patricia L; Hewitt, L Mark; Peru, Kerry M; Headley, John V; Brunswick, Pamela; Shang, Dayue; Parrott, Joanne L

2015-07-01

Naphthenic acids (NAs) are constituents of oil sands process-affected water (OSPW). These compounds can be both toxic and persistent and thus are a primary concern for the ultimate remediation of tailings ponds in northern Alberta's oil sands regions. Recent research has focused on the toxicity of NAs to the highly vulnerable early life-stages of fish. Here we examined fathead minnow embryonic survival, growth and deformities after exposure to extracted NA fraction components (NAFCs), from fresh and aged oil sands process-affected water (OSPW), as well as commercially available NA mixtures. Commercial NA mixtures were dominated by acyclic O2 species, while NAFCs from OSPW were dominated by bi- and tricyclic O2 species. Fathead minnow embryos less than 24h old were reared in tissue culture plates terminating at hatch. Both NAFC and commercial NA mixtures reduced hatch success, although NAFCs from OSPW were less toxic (EC50=5-12mg/L, nominal concentrations) than commercial NAs (2mg/L, nominal concentrations). The toxicities of NAFCs from aged and fresh OSPW were similar. Embryonic heart rates at 2 days post-fertilization (dpf) declined with increasing NAFC exposure, paralleling patterns of hatch success and rates of cardiovascular abnormalities (e.g., pericardial edemas) at hatch. Finfold deformities increased in exposures to commercial NA mixtures, not NAFCs. Thus, commercial NA mixtures are not appropriate surrogates for NAFC toxicity. Further work clarifying the mechanisms of action of NAFCs in OSPW, as well as comparisons with additional aged sources of OSPW, is merited. Crown Copyright © 2015. Published by Elsevier B.V. All rights reserved.

An improved in-house lysis-filtration protocol for bacterial identification from positive blood culture bottles with high identification rates by MALDI-TOF MS.

PubMed

Tsuchida, Sachio; Murata, Syota; Miyabe, Akiko; Satoh, Mamoru; Takiwaki, Masaki; Matsushita, Kazuyuki; Nomura, Fumio

2018-05-01

Matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) is now a well-established method for identification of microorganisms from positive blood cultures. Pretreatments to effectively remove non-bacterial proteins are a prerequisite for successful identification, and a variety of protocols have been reported. Although commercially available kits, mainly the Sepsityper Kit, are increasingly used, the identification rates reported often are not satisfactory, particularly for Gram-positive isolates. We developed a new, in-house lysis-filtration protocol and prospectively evaluated its performance compared to the Sepsityper kit. The in-house protocol consists of three simple steps: lysis by ammonium chloride, aspiration with a syringe fitted with a 0.45-μm membrane, and centrifugation to collect microbes. The novel protocol requires only 20 min. Performance of the in-house protocol was evaluated using a total of 117 monomicrobial cases of positive blood culture. Medium from blood culture bottles was pretreated by the in-house protocol or the commercial kit, and isolated cells were subjected to direct identification by mass spectrometry fingerprinting in parallel with conventional subculturing for reference identification. The overall MALDI-TOF MS-based identification rates with score > 1.7 and > 2.0 obtained using the in-house protocol were 99.2% and 85.5%, respectively, whereas those obtained using the Sepsityper Kit were 85.4% and 61.5%, respectively. For Gram-positive cases, the in-house protocol yielded scores >1.7 and > 2.0 at 98.5% and 76.1%, respectively, whereas the commercial kit yielded these scores at 76.1% and 43.3%, respectively. Although these are preliminary results, these values suggest that this easy lysis-filtration protocol deserves assessment in a larger-scale test. Copyright © 2018 Elsevier B.V. All rights reserved.

Challenges facing academic research in commercializing event-detector implantable devices for an in-vivo biomedical subcutaneous device for biomedical analysis

NASA Astrophysics Data System (ADS)

Juanola-Feliu, E.; Colomer-Farrarons, J.; Miribel-Català, P.; Samitier, J.; Valls-Pasola, J.

2011-05-01

It is widely recognized that the welfare of the most advanced economies is at risk, and that the only way to tackle this situation is by controlling the knowledge economies and dealing with. To achieve this ambitious goal, we need to improve the performance of each dimension in the "knowledge triangle": education, research and innovation. Indeed, recent findings point to the importance of strategies of adding-value and marketing during R+D processes so as to bridge the gap between the laboratory and the market and so ensure the successful commercialization of new technology-based products. Moreover, in a global economy in which conventional manufacturing is dominated by developing economies, the future of industry in the most advanced economies must rely on its ability to innovate in those high-tech activities that can offer a differential added-value, rather than on improving existing technologies and products. It seems quite clear, therefore, that the combination of health (medicine) and nanotechnology in a new biomedical device is very capable of meeting these requisites. This work propose a generic CMOS Front-End Self-Powered In-Vivo Implantable Biomedical Device, based on a threeelectrode amperometric biosensor approach, capable of detecting threshold values for targeted concentrations of pathogens, ions, oxygen concentration, etc. Given the speed with which diabetes can spread, as diabetes is the fastest growing disease in the world, the nano-enabled implantable device for in-vivo biomedical analysis needs to be introduced into the global diabetes care devices market. In the case of glucose monitoring, the detection of a threshold decrease in the glucose level it is mandatory to avoid critic situations like the hypoglycemia. Although the case study reported in this paper is complex because it involves multiple organizations and sources of data, it contributes to extend experience to the best practices and models on nanotechnology applications and commercialization.

Inductive knowledge acquisition experience with commercial tools for space shuttle main engine testing

NASA Technical Reports Server (NTRS)

Modesitt, Kenneth L.

1990-01-01

Since 1984, an effort has been underway at Rocketdyne, manufacturer of the Space Shuttle Main Engine (SSME), to automate much of the analysis procedure conducted after engine test firings. Previously published articles at national and international conferences have contained the context of and justification for this effort. Here, progress is reported in building the full system, including the extensions of integrating large databases with the system, known as Scotty. Inductive knowledge acquisition has proven itself to be a key factor in the success of Scotty. The combination of a powerful inductive expert system building tool (ExTran), a relational data base management system (Reliance), and software engineering principles and Computer-Assisted Software Engineering (CASE) tools makes for a practical, useful and state-of-the-art application of an expert system.

Integration of a CAD System Into an MDO Framework

NASA Technical Reports Server (NTRS)

Townsend, J. C.; Samareh, J. A.; Weston, R. P.; Zorumski, W. E.

1998-01-01

NASA Langley has developed a heterogeneous distributed computing environment, called the Framework for Inter-disciplinary Design Optimization, or FIDO. Its purpose has been to demonstrate framework technical feasibility and usefulness for optimizing the preliminary design of complex systems and to provide a working environment for testing optimization schemes. Its initial implementation has been for a simplified model of preliminary design of a high-speed civil transport. Upgrades being considered for the FIDO system include a more complete geometry description, required by high-fidelity aerodynamics and structures codes and based on a commercial Computer Aided Design (CAD) system. This report presents the philosophy behind some of the decisions that have shaped the FIDO system and gives a brief case study of the problems and successes encountered in integrating a CAD system into the FEDO framework.

To give or sell human gametes - the interplay between pragmatics, policy and ethics

PubMed Central

Daniels, K

2000-01-01

The ever-growing acceptance and use of assisted human reproduction techniques has caused demand for "donated" sperm and eggs to outstrip supply. Medical professionals and others argue that monetary reward is the only way to recruit sufficient numbers of "donors". Is this a clash between pragmatics and policy/ethics? Where monetary payments are the norm, alternative recruitment strategies used successfully elsewhere may not have been considered, nor the negative consequences of commercialism on all participants thought through. Considerations leading some countries to ban the buying and selling of sperm, eggs and embryos are outlined and a case made that the collective welfare of all involved parties be the primary consideration in this, at times heated, debate. Key Words: Gametes • gifting • selling • ethics • policy PMID:10860215

Commercial aviation in-flight emergencies and the physician.

PubMed

Cocks, Robert; Liew, Michele

2007-02-01

Commercial aviation in-flight emergencies are relatively common, so it is likely that a doctor travelling frequently by air will receive a call for help at some stage in their career. These events are stressful, even for experienced physicians. The present paper reviews what is known about the incidence and types of in-flight emergencies that are likely to be encountered, the international regulations governing medical kits and drugs, and the liability, fitness and indemnity issues facing 'Good Samaritan' medical volunteers. The medical and aviation literature was searched, and information was collated from airlines and other sources regarding medical equipment available on board commercial aircraft. Figures for the incidence of significant in-flight emergencies are approximately 1 per 10-40 000 passengers, with one death occurring per 3-5 million passengers. Medically related diversion of an aircraft following an in-flight emergency may occur in up to 7-13% of cases, but passenger prescreening, online medical advice and on-board medical assistance from volunteers reduce this rate. Medical volunteers may find assisting with an in-flight emergency stressful, but should acknowledge that they play a vital role in successful outcomes. The medico-legal liability risk is extremely small, and various laws and industry indemnity practices offer additional protection to the volunteer. In addition, cabin crew receive training in a number of emergency skills, including automated defibrillation, and are one of several sources of help available to the medical volunteer, who is not expected to work alone.

DVB-S2 Experiment over NASA's Space Network

NASA Technical Reports Server (NTRS)

Downey, Joseph A.; Evans, Michael A.; Tollis, Nicholas S.

2017-01-01

The commercial DVB-S2 standard was successfully demonstrated over NASAs Space Network (SN) and the Tracking Data and Relay Satellite System (TDRSS) during testing conducted September 20-22nd, 2016. This test was a joint effort between NASA Glenn Research Center (GRC) and Goddard Space Flight Center (GSFC) to evaluate the performance of DVB-S2 as an alternative to traditional NASA SN waveforms. Two distinct sets of tests were conducted: one was sourced from the Space Communication and Navigation (SCaN) Testbed, an external payload on the International Space Station, and the other was sourced from GRCs S-band ground station to emulate a Space Network user through TDRSS. In both cases, a commercial off-the-shelf (COTS) receiver made by Newtec was used to receive the signal at White Sands Complex. Using SCaN Testbed, peak data rates of 5.7 Mbps were demonstrated. Peak data rates of 33 Mbps were demonstrated over the GRC S-band ground station through a 10MHz channel over TDRSS, using 32-amplitude phase shift keying (APSK) and a rate 89 low density parity check (LDPC) code. Advanced features of the DVB-S2 standard were evaluated, including variable and adaptive coding and modulation (VCMACM), as well as an adaptive digital pre-distortion (DPD) algorithm. These features provided additional data throughput and increased link performance reliability. This testing has shown that commercial standards are a viable, low-cost alternative for future Space Network users.

EDITORIAL: Commercial opportunities for neural engineers

NASA Astrophysics Data System (ADS)

Cavuoto, James

2008-03-01

Research and academic professionals in neural engineering know well the promise the field offers for advancing our understanding of basic neuroscience and devising new therapies for treating neurological diseases and disorders. But there is also considerable commercial opportunity for new start-up companies in several areas of neural engineering. The neurotechnology industry, which includes firms that manufacture neuromodulation devices, neural prostheses, neurorehabilitation systems, and neurosensing devices, is forecast to grow to grow from 3.6 billion this year to 8.8 billion in 2012, according to a recently published market research study from Neurotech Reports. In recent years, there have been several successful spinoffs of neurotechnology startup firms that originated with research at universities and clinical institutions. In many cases, the academic researchers who invented the new technology or product innovation have stayed on with their startup firms after receiving funding from venture capital firms, or after going public. Among the most successful neurotechnology industry spinoffs in recent years were: Cyberkinetics Inc., Foxborough, MA, a manufacturer of brain-computer interface devices based on research at Brown University. John Donoghue, a professor and chairman of the department of neuroscience at Brown University and executive director of the brain science program at Brown, founded the company in 2001 and remains on board as the chief scientific officer. Synapse Biomedical, Inc., Oberlin, OH, a manufacturer of diaphragm pacing systems, based on research at Case Western Reserve University. Raymond Onders, director of minimal invasive surgery and associate professor at University Hospital Case Medical Center in Cleveland, was the primary researcher. He was helped by J. Thomas Mortimer, professor emeritus of biomedical engineering at Case, and it was Mortimer who came up with the name NeuRx for the device. Onders performed his first surgical implant of the device in 2000. Anthony Ignagni, who worked with Mortimer and Onders as project director and chief biomedical engineer, became a co-founder of Synapse and is currently president and CEO. Afferent Corp., Providence, RI, a manufacturer of sensory stimulation systems based on research at Boston University, Afferent's technology is based on work by James Collins, professor of biomedical engineering at Boston University, who showed that low-level stochastic, or random, vibrations improved sense of touch. Collins went on to demonstrate that generating a subthreshold noise in the sensory pathways with a random electrical stimulation improves detectability of weak mechanical stimuli. In 1999 entrepreneur Jason Harry licensed the stochastic resonance technology from Boston University and received help from the Community Technology Fund-the university's technology transfer incubator. NeuroNexus Technologies, Inc., Ann Arbor, MI, a manufacturer of implanted neural probes, based on a program at the University of Michigan. NeuroNexus was spun out of UM's Center for Neural Communications Technology. Daryl Kipke, head of the Neural Engineering Laboratory at the university, started up NeuroNexus with several colleagues and currently serves as president and CEO. Commercialization issues were discussed recently at a preconference workshop at the 2007 meeting of the International Neuromodulation Society in Acapulco, Mexico. In the session, which was chaired by Chris Coburn of the Cleveland Clinic, neurotech entrepreneurs John Bowers from Northstar Neuroscience and Ben Pless, formerly of NeuroPace, shared their experiences bringing neuromodulation therapies to market. Coburn related his observations from the Cleveland Clinic, which has spun off 22 companies over the last five years. He cited several factors that would influence a neurotech startup's market potential, such as identifying the regulatory pathway, any predicate devices that exist, and the revenue potential for potential investors. Bowers cited several factors that would be critical for the growth of the industry, including reaching out to the 'influential implanters' and pushing reimbursement based on quality of life improvements, rather than mortality. Pless provided an overview of patent-related issues affecting neuromodulation devices. He noted that there have been 2000 issued patents for neuromodulation devices, most of them involving the peripheral nervous system. The example set by these companies and other startups in the neurotechnology industry should remind neural engineering researchers that there are plenty of opportunities for commercial success based on promising research at university and clinical research laboratories. Given the wide range of help and information that is available to potential entrepreneurs in this field, we expect to see many more examples of neurotechnology spinoffs in the years ahead.

A drunken search in crystallization space.

PubMed

Fazio, Vincent J; Peat, Thomas S; Newman, Janet

2014-10-01

The REMARK280 field of the Protein Data Bank is the richest open source of successful crystallization information. The REMARK280 field is optional and currently uncurated, so significant effort needs to be applied to extract reliable data. There are well over 15 000 crystallization conditions available commercially from 12 different vendors. After putting the PDB crystallization information and the commercial cocktail data into a consistent format, these data are used to extract information about the overlap between the two sets of crystallization conditions. An estimation is made as to which commercially available conditions are most appropriate for producing well diffracting crystals by looking at which commercial conditions are found unchanged (or almost unchanged) in the PDB. Further analyses include which commercial kits are the most appropriate for shotgun or more traditional approaches to crystallization screening. This analysis suggests that almost 40% of the crystallization conditions found currently in the PDB are identical or very similar to a commercial condition.

Maintenance and Safety Practices of Escalator in Commercial Buildings

NASA Astrophysics Data System (ADS)

Afida Isnaini Janipha, Nurul; Nur Aina Syed Alwee, Sharifah; Ariff, Raihan Mohd; Ismail, Faridah

2018-02-01

The escalator is very crucial to transport a person from one place to another. Nevertheless, there are many cases recorded the accidents in relation to escalator. These may occur due to lack of maintenance which leads to systems breakdown, poor safety practices, wear and tear, users’ negligence and others. Thus, proper maintenance systems need to be improvised to prevent and reduce escalator accident in future. This research was aimed to determine the escalator maintenance activities and safety practices in a commercial building. Three case studies were selected within Selangor area. Semi-structured interviews were conducted for collecting data from these three case studies. To achieve the aim of this research, the study was carried out on the maintenance activities, safety practices and cost related to escalator maintenance. As one of the important means of access in building, it is very crucial to increase effectiveness of escalator particularly in commercial building. It is expected that readers will get clear information on the maintenance activities and safety practices of escalator in commercial building.

Changes to dietary intake during a 12-week commercial web-based weight loss program: a randomized controlled trial.

PubMed

Hutchesson, M J; Collins, C E; Morgan, P J; Watson, J F; Guest, M; Callister, R

2014-01-01

The primary aim of this secondary analysis was to compare changes in dietary intake among participants randomized to two versions of a 12-week commercial web-based weight loss program (basic or enhanced) with a waiting-list control. An additional investigation compared changes in dietary intake of successful participants (weight loss ≥5%) with those not successful. Dietary intake was assessed at baseline and 12 weeks using a validated 120-item semiquantitative food frequency questionnaire. Adults (n=268, 60% female participants, body mass index 32.1 ± 3.9) classified as plausible reporters of energy intake were included in the analyses. Analysis of covariance with baseline observations carried forward for drop-outs (n=38) was used. The basic and enhanced groups significantly increased their percentage of energy contribution from fruits and reduced energy-dense, nutrient-poor foods compared with controls (P<0.001). Successful participants (n=49) reported superior improvements in dietary intake including greater reductions in the mean daily energy intake (P<0.001), the percentage of energy from energy-dense, nutrient-poor foods (-12.0% E vs -4.3% E, P<0.001) and greater increases in the energy contribution from fruits (P<0.001), vegetables (P=0.003) and breads/cereals (P=0.02). Use of a commercial web-based weight loss program facilitated some improvements in the dietary intake. The enhanced web-based tools appeared not to have generated greater improvements in reported dietary intake, compared with the basic or control groups. Those who achieved a weight loss of ≥5% improved their dietary intake in line with the program recommendations and dietary guidelines. Further research to determine web-based components that may improve success and the reasons why programs are successful for some participants is required.

Criteria for successful government-industry-academic partnerships

NASA Astrophysics Data System (ADS)

Brannon, David P.

1996-03-01

The mission of the Commercial Remote Sensing Program (CRSP) Office at NASA's John C. Stennis Space Center is to maximize U.S. industry's commercial use of remote sensing and related space-based technologies and to develop advanced technical responses to spatial information requirements. The CRSP Office carries out this mission by offering several commercial partnership programs that help companies to apply remote sensing technologies in business applications and to buy down the risk of bringing new or improved products and services to market. Through its commercial partnerships, the CRSP seeks to increase the market demand for remote sensing products and related advanced technologies, thus increasing the use and reducing the cost of spatial information.

Creating Processes Associated with Providing Government Goods and Services Under the Commercial Space Launch Act at Kennedy Space Center

NASA Technical Reports Server (NTRS)

Letchworth, Janet F.

2011-01-01

Kennedy Space Center (KSC) has decided to write its agreements under the Commercial Space Launch Act (CSLA) authority to cover a broad range of categories of support that KSC could provide to our commercial partner. Our strategy was to go through the onerous process of getting the agreement in place once and allow added specificity and final cost estimates to be documented on a separate Task Order Request (TOR). This paper is written from the implementing engineering team's perspective. It describes how we developed the processes associated with getting Government support to our emerging commercial partners, such as SpaceX and reports on our success to date.

Satisfactory short-term outcomes of the STABILISE technique for type B aortic dissection.

PubMed

Melissano, Germano; Bertoglio, Luca; Rinaldi, Enrico; Mascia, Daniele; Kahlberg, Andrea; Loschi, Diletta; De Luca, Monica; Monaco, Fabrizio; Chiesa, Roberto

2018-03-29

The aim of this study was to evaluate the perioperative and short-term results in a cohort of patients treated during the last year at our institution with the stent-assisted balloon-induced intimal disruption and relamination in aortic dissection repair (STABILISE) technique for acute complicated aortic dissection. Between June 2016 and June 2017, 10 patients (all male; mean age, 62.6 ± 7.4 years) received treatment for acute complicated aortic dissection with the STABILISE technique. After a standard provisional extension to induce complete attachment procedure using the commercially available endovascular dissection system (Cook Medical, Bloomington, Ind), the distal stent graft area and the bare stent area were ballooned to completely exclude the thoracic false lumen (FL) and to obtain a single-channeled abdominal aorta. Computed tomography was routinely performed within the first postoperative week before discharge and then at 3 months, at 6 months, and yearly thereafter. The technical and clinical success rates were analyzed. The 30-day technical and clinical success rates were 100%, with complete thrombosis of the thoracic FL and no type I endoleak. Malperfusion was resolved in all cases. No aortic ruptures were recorded, and no open conversion was required. One case of delayed spinal cord ischemia fully resolved within the discharge period. Predischarge computed tomography showed complete thrombosis of the thoracic FL in all cases. In two cases, some degree of patency of the abdominal FL was observed. At short-term follow-up, the overall aortic diameters remained stable with no further dilation. The STABILISE technique was safe and feasible in this cohort of patients, with complete thrombosis of the thoracic FL and creation of a single-channeled aorta in most cases. Further studies are needed to ascertain the long-term behavior of the treated aorta. Copyright © 2018 Society for Vascular Surgery. Published by Elsevier Inc. All rights reserved.

Identification of "Known Unknowns" Utilizing Accurate Mass Data and ChemSpider

NASA Astrophysics Data System (ADS)

Little, James L.; Williams, Antony J.; Pshenichnov, Alexey; Tkachenko, Valery

2012-01-01

In many cases, an unknown to an investigator is actually known in the chemical literature, a reference database, or an internet resource. We refer to these types of compounds as "known unknowns." ChemSpider is a very valuable internet database of known compounds useful in the identification of these types of compounds in commercial, environmental, forensic, and natural product samples. The database contains over 26 million entries from hundreds of data sources and is provided as a free resource to the community. Accurate mass mass spectrometry data is used to query the database by either elemental composition or a monoisotopic mass. Searching by elemental composition is the preferred approach. However, it is often difficult to determine a unique elemental composition for compounds with molecular weights greater than 600 Da. In these cases, searching by the monoisotopic mass is advantageous. In either case, the search results are refined by sorting the number of references associated with each compound in descending order. This raises the most useful candidates to the top of the list for further evaluation. These approaches were shown to be successful in identifying "known unknowns" noted in our laboratory and for compounds of interest to others.

[Local fixation of antibiotics by fibrin spray : In bone defects with soft tissue involvement].

PubMed

Janko, Maren; Nau, Christoph; Marzi, Ingo; Frank, Johannes

2017-02-01

In acute and chronic bone infections with concomitant soft tissue involvement the current gold standard is radical surgical debridement including explantation of the infected prosthetic devices. This is followed by initiation of systemic antibiotic therapy appropriate for the antibiogram. Several revision operations are often necessary to achieve complete healing. Additional treatment with local antibiotics or antibiotic-containing substances is routinely used in bone surgery. Apart from the typical procedures with commercially available products, we have conducted a study with 21 patients by application of local antibiotic treatment in combination with the fibrin glue spray technique and evaluated the results. Out of nine wounds of the lower extremities with bone involvement, total healing could be achieved in eight cases. We were also successful in two out of three very complex pelvic wounds; however, as expected the implant infections were complicated. Out of the seven desolate cases we were only able to achieve complete long-term healing in two cases. In the meantime we routinely use the described method in such special disastrous infection situations; however, this is carried out only in combination with established surgical procedures in sepsis surgery and anti-infection management.

Concise Review: Process Development Considerations for Cell Therapy

PubMed Central

Brieva, Thomas; Raviv, Lior; Rowley, Jon; Niss, Knut; Brandwein, Harvey; Oh, Steve; Karnieli, Ohad

2015-01-01

The development of robust and well-characterized methods of production of cell therapies has become increasingly important as therapies advance through clinical trials toward approval. A successful cell therapy will be a consistent, safe, and effective cell product, regardless of the cell type or application. Process development strategies can be developed to gain efficiency while maintaining or improving safety and quality profiles. This review presents an introduction to the process development challenges of cell therapies and describes some of the tools available to address production issues. This article will provide a summary of what should be considered to efficiently advance a cellular therapy from the research stage through clinical trials and finally toward commercialization. The identification of the basic questions that affect process development is summarized in the target product profile, and considerations for process optimization are discussed. The goal is to identify potential manufacturing concerns early in the process so they may be addressed effectively and thus increase the probability that a therapy will be successful. Significance The present study contributes to the field of cell therapy by providing a resource for those transitioning a potential therapy from the research stage to clinical and commercial applications. It provides the necessary steps that, when followed, can result in successful therapies from both a clinical and commercial perspective. PMID:26315572

Commercialization of LARC(TradeMark)-SI Polyimide Technology

NASA Technical Reports Server (NTRS)

Bryant, Robert G.

2008-01-01

LARC(TradeMark)-SI, Langley Research Center-Soluble Imide, was developed in 1992. This new polyimide won a 1995 Research and Development 100 Award, with the first patent issuing in 1997 and subsequent issued patents in 1998 and 2000. Currently, this polymer has been successfully licensed by NASA, and has generated revenues in excess of 1.4 million dollars. This might seem insignificant in comparison to industrially developed technology, where the customer is understood, technologies that use a novel assembly of commercial off the shelf (COTS) components, or software patents and "method based" innovations that do not require any material beyond labor, as examples. However, consider that LARC(TradeMark)-SI competes in areas currently dominated by traditional materials at a cost disadvantage ($350/lb) and that the physical-mechanical properties of LARC(TradeMark)-SI are similar to other high performance polymers. Indeed the success of this particular polymer was due to many factors and many lessons learned to the point that the invention was the most important, but least significant part in the commercialization of this material. This brief paper outlines the significant factors that occurred to make this technology available for the public access and application development that led to the licensing success of this material.

75 FR 51416 - Defense Federal Acquisition Regulation Supplement; Acquisition of Commercial Items

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-20

... be used for the acquisition of commercial items, and revised the language to address the conditions... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System 48 CFR Parts 202, 212, and 234 [DFARS Case 2008-D011] Defense Federal Acquisition Regulation Supplement; Acquisition of Commercial Items...

LANDSAT follow-on experiment: Gulf of Mexico menhaden and thread herring resources investigation. [Gulf of Mexico

NASA Technical Reports Server (NTRS)

Savastano, K. J. (Principal Investigator); Kemmerer, A. J.; Leming, T. D.; Holley, H.; Faller, K.

1976-01-01

The author has identified the following significant results. The most significant achievements realized thus far include the successful charting of high probability fishing areas from LANDSAT MSS data and the successful simulation of an operational satellite system to provide tactical information for the commercial harvest of menhaden.

"Sisters Under the Skin": Race and Gender in Zora Neale Hurston's "Tell My Horse."

ERIC Educational Resources Information Center

Meisenhelder, Susan

1995-01-01

No work by Zora Neale Hurston has received harsher critical evaluation than her anthropological study of Haiti and Jamaica, "Tell My Horse." Although her aim in part was to write a commercially successful popular book, she also aimed, with some success, to offer significant social commentary. (SLD)

Fully digital data processing during cardiovascular implantable electronic device follow-up in a high-volume tertiary center.

PubMed

Staudacher, Ingo; Nalpathamkalam, Asha Roy; Uhlmann, Lorenz; Illg, Claudius; Seehausen, Sebastian; Akhavanpoor, Mohammadreza; Buchauer, Anke; Geis, Nicolas; Lugenbiel, Patrick; Schweizer, Patrick A; Xynogalos, Panagiotis; Zylla, Maura M; Scholz, Eberhard; Zitron, Edgar; Katus, Hugo A; Thomas, Dierk

2017-10-11

Increasing numbers of patients with cardiovascular implantable electronic devices (CIEDs) and limited follow-up capacities highlight unmet challenges in clinical electrophysiology. Integrated software (MediConnect ® ) enabling fully digital processing of device interrogation data has been commercially developed to facilitate follow-up visits. We sought to assess feasibility of fully digital data processing (FDDP) during ambulatory device follow-up in a high-volume tertiary hospital to provide guidance for future users of FDDP software. A total of 391 patients (mean age, 70 years) presenting to the outpatient department for routine device follow-up were analyzed (pacemaker, 44%; implantable cardioverter defibrillator, 39%; cardiac resynchronization therapy device, 16%). Quality of data transfer and follow-up duration were compared between digital (n = 265) and manual processing of device data (n = 126). Digital data import was successful, complete and correct in 82% of cases when early software versions were used. When using the most recent software version the rate of successful digital data import increased to 100%. Software-based import of interrogation data was complete and without failure in 97% of cases. The mean duration of a follow-up visit did not differ between the two groups (digital 18.7 min vs. manual data transfer 18.2 min). FDDP software was successfully implemented into the ambulatory follow-up of patients with implanted pacemakers and defibrillators. Digital data import into electronic patient management software was feasible and supported the physician's workflow. The total duration of follow-up visits comprising technical device interrogation and clinical actions was not affected in the present tertiary center outpatient cohort.

[Characteristics of non-marital and non-commercial heterosexual transmission of HIV infection in Miao-Dong Autonomous prefecture of Qiandongnan].

PubMed

Yu, Q Y; Wang, F L; Xu, P; Wen, H J; Xiong, Y X; Yang, J; Long, Y; He, H J; Shi, J; Lyu, P

2017-11-06

Objective: The goal of this research was to understand the demographic distribution and related factors of non-marital and non-commercial heterosexual transmission (non-commercial transmission) for HIV/AIDS (human immunodeficiency virus/acquired immunodeficiency syndrome). Methods: Data related to HIV/AIDS infected by non-marital heterosexual transmission and whose present address was in Qian Dongnan, were collected from Information System on the HIV/AIDS Prevention and Control. Information included demographic characteristics, the members of non-marital sex partners, transmission path, detection source, CD4(+)T lymphocyte level, et al. cases belong to homosexual history, injective drug use or non-classified non-marital heterosexuality transmission were excluded, totally collect HIV/AIDS 919 cases. Multivariate logistic regressions were used to analyze potential factors associated with non-marital and non-commercial heterosexual transmission. In addition, in March and June 2017, using a convenience sampling, we conducted one-to-one interviews among 10 HIV/AIDS who were infected by non-marital heterosexuality and had non-marital and non-commercial heterosexual experience in Kaili Center for Disease Control and Prevention. The content of the interview included basic information, sexual orientation, the main place of making friends and sexual behavior, attitude to commercial heterosexuality and non-martial and non-commercial heterosexuality and so on. Results: Out of the 919 cases, 645 (70.2%) were male, the proportion of non-commercial transmission was 55.06% (506). The proportion of female HIV/AIDS with non-commercial transmission was 84.7% (232), which was higher than male (42.5%(274)) (χ(2)=138.35, P< 0.001). The proportion of Han HIV/AIDS with non-commercial transmission was 61.5% (275), which was higher than other religion (52.2%(412)) (χ(2)=6.32, P= 0.012). The proportion of HIV/AIDS with non-commercial transmission who had 0-5 non-marital sexual partners was 58.8% (498), which was higher than who had>5 non-marital sexual partners (11.1%(8)) (χ(2)=61.10, P< 0.001). The proportion of HIV/AIDS with non-commercial transmission who lived mobile was 72.9% (94), which was higher than who lived fixedly (52.2%(412)) (χ(2)=19.34, P< 0.001). Qualitative interviews results revealed that the age of the respondents were 22-69. Respondents whose ages are in 22-34 were more likely to use mobile phone (4/10) and respondents whose ages are in 35-69 were less likely to look partners through party and the context of working. Conclusion: The proportion of cases being infected by non-marital and non-commercial heterosexual transmission in Qian dongnan was higher than general national levels. The characteristics of sex, marriage status, migration, vocation, the members of non-marital sex partners were significant differed between commercial heterosexual transmission and non-marital and non-commercial heterosexual transmission.

Molecular Epidemiology of Streptococcus uberis Clinical Mastitis in Dairy Herds: Strain Heterogeneity and Transmission

PubMed Central

Leigh, J. A.; Bradley, A. J.; Archer, S. C.; Emes, R. D.; Green, M. J.

2015-01-01

Multilocus sequence typing was successfully completed on 494 isolates of Streptococcus uberis from clinical mastitis cases in a study of 52 commercial dairy herds over a 12-month period. In total, 195 sequence types (STs) were identified. S. uberis mastitis cases that occurred in different cows within the same herd and were attributed to a common ST were classified as potential transmission events (PTEs). Clinical cases attributed to 35 of the 195 STs identified in this study were classified PTE. PTEs were identified in 63% of the herds. PTE-associated cases, which include the first recorded occurrence of that ST in that herd (index case) and all persistent infections with that PTE ST, represented 40% of all the clinical mastitis cases and occurred in 63% of the herds. PTE-associated cases accounted for >50% of all S. uberis clinical mastitis cases in 33% of the herds. Nine STs (ST-5, -6, -20, -22, -24, -35, -233, -361, and -512), eight of which were grouped within a clonal complex (sharing at least four alleles), were statistically overrepresented (OVR STs). The findings indicate that 38% of all clinical mastitis cases and 63% of the PTEs attributed to S. uberis in dairy herds may be caused by the nine most prevalent strains. The findings suggest that a small subset of STs is disproportionally important in the epidemiology of S. uberis mastitis in the United Kingdom, with cow-to-cow transmission of S. uberis potentially occurring in the majority of herds in the United Kingdom, and may be the most important route of infection in many herds. PMID:26491180

Pre-Packaged Commercial PACE Financing Solutions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wallander, Michael

The objective of this project was to demonstrate a more streamlined method for facilitating commercial property assessed clean energy (PACE) retrofits. The Recipient aimed to prove that energy efficiency performance of simple, pre-packaged technologies (e.g., lighting and heating, ventilation and air conditioning (HVAC)) can be accurately estimated without the need for a detailed energy audit. A successful project would inspire consumer confidence in undertaking cost-effective retrofits.

Commercial and Institutional Case Studies

EPA Pesticide Factsheets

Throughout the country, commercial and institutional (CI) building owners and facility managers are taking actions to reduce their water use, implementing many of the operations and maintenance, retrofit, and replacement projects.

Strengthening Children's Advertising Defenses: The Effects of Forewarning of Commercial and Manipulative Intent.

PubMed

Rozendaal, Esther; Buijs, Laura; van Reijmersdal, Eva A

2016-01-01

This study investigated whether a forewarning of advertising's intent can increase children's (N = 159, 8-10 years old) defenses against television commercials to lower their desire for advertised products. Two different forewarnings were tested, one for advertising's commercial intent or warning for the promotional nature, and one for advertising's manipulative intent or warning for the deceptive nature. Results showed that only the warning of manipulative intent prior to advertising exposure was successful in increasing children's advertising defenses. This forewarning activated children's attitudinal advertising literacy (i.e., skepticism toward the commercial), which in turn led to lower advertised product desire. The forewarning of commercial intent was not effective in strengthening children's advertising defenses. These findings have important implications for interventions that aim to lower children's desire for (unhealthy) advertised products by activating their advertising literacy.

Commercial Orbital Transportation Services (COTS) Demonstrations

NASA Technical Reports Server (NTRS)

Lindenmoyer, Allan

2006-01-01

U.S. space policy directs pursuit of commercial opportunities for providing transportation and other services low Earth orbit and beyond. COTS Project established to implement policy. COTS strategy: Phase 1) Assist industry with system development/demonstrations (COTS Demos); Phase 2) Procure commercial services for ISS logistics support. COTS Demonstrations competition completed in 10 months. Two industry partners selected for funded Space Act Agreements: 1) SpaceX & Rocketplane-Kistler; and 2) Unfunded Space Act Agreements in work with other competitors. COTS budget of $500 M thru 2010, with pay for performance milestone approach. Cargo flight demonstrations planned for 2008 and 2009: Crew flight demonstration options for 2011-2012. Commercial cargo transportation services potentially available as early as 2009-2010. Successful COTS partners may open new space markets and provide reliable, cost effective cargo and crew transportation services, a new era for commercial space.

10 CFR 431.408 - Preemption of State regulations for covered equipment other than electric motors and commercial...

Code of Federal Regulations, 2014 CFR

2014-01-01

... conservation standard, or water conservation standard (in the case of commercial prerinse spray valves or... other than electric motors and commercial heating, ventilating, air-conditioning and water heating products. 431.408 Section 431.408 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ENERGY EFFICIENCY PROGRAM...

A Study of Fan Stage/Casing Interaction Models

NASA Technical Reports Server (NTRS)

Lawrence, Charles; Carney, Kelly; Gallardo, Vicente

2003-01-01

The purpose of the present study is to investigate the performance of several existing and new, blade-case interactions modeling capabilities that are compatible with the large system simulations used to capture structural response during blade-out events. Three contact models are examined for simulating the interactions between a rotor bladed disk and a case: a radial and linear gap element and a new element based on a hydrodynamic formulation. The first two models are currently available in commercial finite element codes such as NASTRAN and have been showed to perform adequately for simulating rotor-case interactions. The hydrodynamic model, although not readily available in commercial codes, may prove to be better able to characterize rotor-case interactions.

13 CFR 305.2 - Award requirements.

Code of Federal Regulations, 2011 CFR

2011-01-01

...) Acquisition, design and engineering, construction, rehabilitation, alteration, expansion, or improvement of... opportunities for the successful establishment or expansion of industrial or commercial plants or facilities in...

13 CFR 305.2 - Award requirements.

Code of Federal Regulations, 2014 CFR

2014-01-01

...) Acquisition, design and engineering, construction, rehabilitation, alteration, expansion, or improvement of... opportunities for the successful establishment or expansion of industrial or commercial plants or facilities in...

13 CFR 305.2 - Award requirements.

Code of Federal Regulations, 2010 CFR

2010-01-01

...) Acquisition, design and engineering, construction, rehabilitation, alteration, expansion, or improvement of... opportunities for the successful establishment or expansion of industrial or commercial plants or facilities in...

13 CFR 305.2 - Award requirements.

Code of Federal Regulations, 2012 CFR

2012-01-01

...) Acquisition, design and engineering, construction, rehabilitation, alteration, expansion, or improvement of... opportunities for the successful establishment or expansion of industrial or commercial plants or facilities in...

13 CFR 305.2 - Award requirements.

Code of Federal Regulations, 2013 CFR

2013-01-01

...) Acquisition, design and engineering, construction, rehabilitation, alteration, expansion, or improvement of... opportunities for the successful establishment or expansion of industrial or commercial plants or facilities in...

Titre distribution patterns of infectious haematopoietic necrosis virus in ovarian fluids of hatchery and feral salmon populations

USGS Publications Warehouse

Mulcahy, D.; Pascho, R.J.; Jenes, C.K.

1983-01-01

Infectious haematopoietic mecrosis virus (IHNV) is enzootic in virtually all populations of sockeye salmon, Oncorhynchus nerka (Walbaum), and in populations of chinook salmon, O. tshawytscha (Walbaum), of the Sacramento River drainage in California. This disease is an obstacle in hatcheries using brood stocks from these populations. However, naturally spawning sockeye salmon are highly successful and are the most important commercially fished salmon species in the United States. Most of the commercial landings of sockeye salmon are of feral fish originating in Alaska. The success of natural populations of salmon in which IHNV is enzootic, and the recurrent outbreaks of the disease in hatchery fish, led us to compare IHNW prevalence rates in hatchery and feral salmon populations.

NASA and COTS Electronics: Past Approach and Successes - Future Considerations

NASA Technical Reports Server (NTRS)

LaBel, Kenneth A.

2018-01-01

NASA has a long history of using commercial grade electronics in space. In this talk, a brief history of NASAâ's trends and approaches to commercial grade electronics focusing on processing and memory systems will be presented. This will include providing summary information on the space hazards to electronics as well as NASA mission trade space. We will also discuss developing recommendations for risk management approaches to Electrical, Electronic and Electromechanical (EEE) parts and reliability in space. The final portion of the talk will discuss emerging aerospace trends and the future for Commercial Off The Shelf (COTS) usage.

TechTracS: NASA's commercial technology management system

NASA Astrophysics Data System (ADS)

Barquinero, Kevin; Cannon, Douglas

1996-03-01

The Commercial Technology Mission is a primary NASA mission, comparable in importance to those in aeronautics and space. This paper will discuss TechTracS, NASA Commercial Technology Management System that has been put into place in FY 1995 to implement this mission. This system is designed to identify and capture the NASA technologies which have commercial potential into an off-the-shelf database application, and then track the technologies' progress in realizing the commercial potential through collaborations with industry. The management system consists of four stages. The first is to develop an inventory database of the agency's entire technology portfolio and assess it for relevance to the commercial marketplace. Those technologies that are identified as having commercial potential will then be actively marketed to appropriate industries—this is the second stage. The third stage is when a NASA-industry partnership is entered into for the purposes of commercializing the technology. The final stage is to track the technology's success or failure in the marketplace. The collection of this information in TechTracS enables metrics evaluation and can accelerate the establishment on direct contacts between and NASA technologist and an industry technologist. This connection is the beginning of the technology commercialization process.

Biosensor Regeneration: A Review of Common Techniques and Outcomes.

PubMed

Goode, J A; Rushworth, J V H; Millner, P A

2015-06-16

Biosensors are ideally portable, low-cost tools for the rapid detection of pathogens, proteins, and other analytes. The global biosensor market is currently worth over 10 billion dollars annually and is a burgeoning field of interdisciplinary research that is hailed as a potential revolution in consumer, healthcare, and industrial testing. A key barrier to the widespread adoption of biosensors, however, is their cost. Although many systems have been validated in the laboratory setting and biosensors for a range of analytes are proven at the concept level, many have yet to make a strong commercial case for their acceptance. Though it is true with the development of cheaper electrodes, circuits, and components that there is a downward pressure on costs, there is also an emerging trend toward the development of multianalyte biosensors that is pushing in the other direction. One way to reduce the cost that is suitable for certain systems is to enable their reuse, thus reducing the cost per test. Regenerating biosensors is a technique that can often be used in conjunction with existing systems in order to reduce costs and accelerate the commercialization process. This article discusses the merits and drawbacks of regeneration schemes that have been proven in various biosensor systems and indicates parameters for successful regeneration based on a systematic review of the literature. It also outlines some of the difficulties encountered when considering the role of regeneration at the point of use. A brief meta-analysis has been included in this review to develop a working definition for biosensor regeneration, and using this analysis only ∼60% of the reported studies analyzed were deemed a success. This highlights the variation within the field and the need to normalize regeneration as a standard process across the field by establishing a consensus term.

Effective strategies to reduce commercial tobacco use in Indigenous communities globally: A systematic review.

PubMed

Minichiello, Alexa; Lefkowitz, Ayla R F; Firestone, Michelle; Smylie, Janet K; Schwartz, Robert

2016-01-11

All over the world, Indigenous populations have remarkably high rates of commercial tobacco use compared to non-Indigenous groups. The high rates of commercial tobacco use in Indigenous populations have led to a variety of health issues and lower life expectancy than the general population. The objectives of this systematic review were to investigate changes in the initiation, consumption and quit rates of commercial tobacco use as well as changes in knowledge, prevalence, community interest, and smoke-free environments in Indigenous populations. We also aimed to understand which interventions had broad reach, what the common elements that supported positive change were and how Aboriginal self-determination was reflected in program implementation. We undertook a systematic review of peer-reviewed publications and grey literature selected from seven databases and 43 electronic sources. We included studies between 1994 and 2015 if they addressed an intervention (including provision of a health service or program, education or training programs) aimed to reduce the use of commercial tobacco use in Indigenous communities globally. Systematic cross-regional canvassing of informants in Canada and internationally with knowledge of Indigenous health and/or tobacco control provided further leads about commercial tobacco reduction interventions. We extracted data on program characteristics, study design and learnings including successes and challenges. In the process of this review, we investigated 73 commercial tobacco control interventions in Indigenous communities globally. These interventions incorporated a myriad of activities to reduce, cease or protect Indigenous peoples from the harms of commercial tobacco use. Interventions were successful in producing positive changes in initiation, consumption and quit rates. Interventions also facilitated increases in the number of smoke-free environments, greater understandings of the harms of commercial tobacco use and a growing community interest in addressing the high rates of commercial tobacco use. Interventions were unable to produce any measured change in prevalence rates. The extent of this research in Indigenous communities globally suggests a growing prioritization and readiness to address the high rates of commercial tobacco use through the use of both comprehensive and tailored interventions. A comprehensive approach that uses multiple activities, the centring of Aboriginal leadership, long term community investments, and the provision of culturally appropriate health materials and activities appear to have an important influence in producing desired change.

Heating systems to maximise efficiency.

PubMed

House, Jeff

2013-09-01

Jeff House, marketing and applications manager, Baxi Commercial, identifies some of the heating options available to the operators of healthcare facilities, and highlights practical examples of successful applications.

Better Buildings Neighborhood Program: BetterBuildings Lowell Final Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Heslin, Thomas

The City of Lowell set four goals at the beginning of the Better Buildings Neighborhood Program: 1. Improve the Downtown Historic Park District’s Carbon Footprint 2. Develop a sustainable and replicable model for energy efficiency in historic buildings 3. Create and retain jobs 4. Promote multi-stakeholder partnerships The City of Lowell, MA was awarded $5 million in May 2010 to conduct energy efficiency retrofits within the downtown National Historical Park (NHP). The City’s target was to complete retrofits in 200,000 square feet of commercial space and create 280 jobs, while adhering to the strict historical preservation regulations that govern themore » NHP. The development of a model for energy efficiency in historic buildings was successfully accomplished. BetterBuildings Lowell’s success in energy efficiency in historic buildings was due to the simplicity of the program. We relied strongly on the replacement of antiquated HVAC systems and air sealing and a handful of talented energy auditors and contractors. BetterBuildings Lowell was unique for the Better Buildings Neighborhood Program because it was the only program that focused solely on commercial properties. BetterBuildings Lowell did target multi-family properties, which were reported as commercial, but the majority of the building types and uses were commercial. Property types targeted were restaurants, office buildings, museums, sections of larger buildings, mixed use buildings, and multifamily buildings. This unique fabric of building type and use allows for a deeper understanding to how different properties use energy. Because of the National Historical Park designation of downtown Lowell, being able to implement energy efficiency projects within a highly regulated historical district also provided valuable research and precedent proving energy efficiency projects can be successfully completed in historical districts and historical buildings. Our program was very successful in working with the local Historic Board, which has jurisdiction in the NHP. The Historic Board was cooperative with any exterior renovations as long as they were not changing the existing aesthetics of the property. If we were replacing a rooftop condenser it needed to be placed where the existing rooftop condenser was located. Receiving proper approval from the Historic Board for any external energy conservation measures was known by all the participating contractors. One area of the retrofits that was contentious regarded venting of the new HVAC equipment. Installing external stacks was not allowed so the contractors had to negotiate with the Historic Board regarding the proper way to vent the equipment that met the needs mechanically and aesthetically. Overall BetterBuildings Lowell was successful at implementing energy and cost saving measures into 31 commercial properties located within the NHP. The 31 retrofits had 1,554,768 square feet of commercial and multifamily housing and a total predicted energy savings exceeding 22,869 a year. Overall the City of Lowell achieved its target goals and is satisfied with the accomplishments of the BetterBuildings program. The City will continue to pursue energy efficient programs and projects.« less

A Rapid Global Effects Capability

DTIC Science & Technology

2016-06-01

and costs to the U.S. government. Companies such as SpaceWorks, SpaceX , Blue Origin, and Masten Space Systems are conducting similar research and...Capability. In the commercial sector, SpaceX Designs is the most noticeable entity in the field of space exploration. They are focusing their research...colonization of Mars by humans. Recently, they have had quite a few important successes. In 2014, SpaceX and their “commercial space program got

FD-CHIRP: hosted payload system engineering lessons

NASA Astrophysics Data System (ADS)

Schueler, Carl F.

2012-10-01

The Commercially Hosted Infrared Payload (CHIRP) Flight Demonstration (FD-CHIRP) launched 21 Sept 2011 was designated a "resounding success" as the first Wide Field-of-View (WFOV) staring infrared (IR) sensor flown in geostationary earth orbit (GEO) with a primary mission of Missile Warning (MW). FD-CHIRP was an Air Force research and development project initiated in July 2008 via an unsolicited industry proposal aimed to mature and reduce the risk of WFOV sensors and ground processing technologies. Unlike the Defense Support Program (DSP) and the Space Based Infrared System (SBIRS) which were acquired via traditional integrated sensor and satellite design, FDCHIRP was developed using the "commercially hosted" approach. The FD-CHIRP host spacecraft and sensor were independently designed, creating significant development risk to the industry proposer, especially under a Firm Fixed Price contract. Yet, within 39 months of contract initiation, FD-CHIRP was launched and successfully operated in GEO to 30 June 2012 at a total cost of 111M including the 82.9M CHIRP commercial-hosting contract and a $28M sensor upgrade. The commercial-hosting contract included sensor and spacecraft modifications, integration and test, design and development of secure Mission Operations and Analysis Centers, launch, and nearly a year of GEO operations with 70 Mbps secure data acquisition. The Air Force extended the contract for six months to continue operations through the end of calendar 2012. This paper outlines system engineering challenges FD-CHIRP overcame and key lessons to smooth development of future commercially hosted missions.

Channeling Polyolefin Molecular Structure - Bulk Property Correlation Strategies for Industrial Applicability

NASA Astrophysics Data System (ADS)

Hule, Rohan; Thurman, Derek; Doufas, Antonios

Polyolefins occupy a significant volume of the polymer products portfolio in commodity and high value applications. Quantifying and optimizing structure-property relationships enables growth in new markets. It is well recognized that coupling lab-based, comprehensive methodologies with bulk properties of interest to industrial environments offer the greatest potential of technology advancement, ultimately leading to commercial success. It is imperative to recognize the existing gap of knowledge translation between lab measurements and industrial-scale operability. This study highlights experimental HDPEs synthesized from dual, single-site, co-supported catalysts that exhibit enhanced solid-state properties such as stiffness, impact and ESCR surpassing conventional trends. Commercial resins across distinct sub-families were included as well. Commonality amongst these resins is bimodality and broad MW distribution with well-defined splits and spreads. Investigations on commercially relevant parameters such as melt strength, melt elasticity and shear thinning established excellent performance for experimental bimodals, corroborating potential benefits compared to commercial HDPEs. To summarize, the effort highlights well-recognized pathways such as improvements in mechanical and melt properties that can be attributed to apposite tuning of polymer chain architecture and MW distribution with implications across myriad markets. Ultimately, this may serve as a pathway for producing innovative products that deliver business success and growth.

Translating cell-based regenerative medicines from research to successful products: challenges and solutions.

PubMed

Bayon, Yves; Vertès, Alain A; Ronfard, Vincent; Egloff, Matthieu; Snykers, Sarah; Salinas, Gabriella Franco; Thomas, Robert; Girling, Alan; Lilford, Richard; Clermont, Gaelle; Kemp, Paul

2014-08-01

The Tissue Engineering & Regenerative Medicine International Society-Europe (TERMIS-EU) Industry Committee as well as its TERMIS-Americas (AM) counterpart intend to address the specific challenges and needs facing the industry in translating academic research into commercial products. Over the last 3 years, the TERMIS-EU Industry Committee has worked with commercial bodies to deliver programs that encourage academics to liaise with industry in proactive collaborations. The TERMIS-EU 2013 Industry Symposium aimed to build on this commercial agenda by focusing on two topics: Operations Management (How to move a process into the good manufacturing practice [GMP] environment) and Clinical Translation (Moving a GMP process into robust trials). These topics were introduced by providing the synergistic business perspective of partnering between the multiple regenerative medicine stakeholders, throughout the life cycle of product development. Seven industry leaders were invited to share their experience, expertise, and strategies. Due to the complex nature of regenerative medicine products, partnering for their successful commercial development seems inevitable to overcome all obstacles by sharing experiences and expertise of all stakeholders. When ideally implemented, the "innovation quotient" of a virtual team resulting from the combination of internal and external project teams can be maximized through maximizing the three main dimensions: core competences, technology portfolio, and alliance management.

A Novel Method of Coating Orthodontic Archwires with Nanoparticles

PubMed Central

Syed, Shibli S; Kulkarni, Dinraj; Todkar, Rohit; Bagul, Ravikiran S; Parekh, Kreena; Bhujbal, Nikita

2015-01-01

Background: The major hazard to the orthodontic tooth movement is the friction developing at the bracket wire interface. In the past, there have been various attempts to reduce this friction. We believe that coating the commercially available orthodontic wires with nanoparticles can result in a successful reduction of this friction. The objective of this study is to develop a novel method of coating orthodontic archwires with nanoparticles. Materials and Methods: Stainless steel (Ormco, CA, USA), titanium molybdenum alloy (Ormco, CA, USA) and nickel-titanium (G and H Wire Company, USA) orthodontic wires with a rectangular cross-section dimension of 0.019”× 0.025”, were selected. The wires were later coated with a uniform and smooth nanoparticle film using 100 ml nanocremics. The coating procedure described in this article is a sol-gel thin film dip coating method. Results: The coating procedure was verified by comparing the surface topography of nanocoated archwires with the commercially available archwires in an environmental scanning electron microscope (ESEM). The ESEM images prove that the surface topography of the coated wires was found to be smoother with less surface deteriorations as compared to the commercially available wires. Conclusion: Commercially available orthodontic wires can be successfully coated using a novel method of sol-gel thin film dip coating method. PMID:26028899

Space technology: A study of the significance of recognition for innovators of spinoff technologies. 1993 activities/1994, 1995 plans

NASA Technical Reports Server (NTRS)

1994-01-01

During the past 30 years as NASA has conducted technology transfer programs, it has gained considerable experience - particularly pertaining to the processes. However, three areas have not had much scrutiny: the examination of the contributions of the individuals who have developed successful spinoffs, the commercial success of the spinoffs themselves, and the degree to which they are understood by the public. In short, there has been limited evaluation to measure the success of technology transfer efforts mandated by Congress. Research conducted during the first year of a three-year NASA grant to the United States Space Foundation has taken the initial steps toward measuring the success of methodologies to accomplish that Congressionally-mandated technology transfer. In particular, the US Space Foundation, in cooperation with ARAC, technology transfer experts; JKA, a nationally recognized themed entertainment design company; and top evaluation consultants, inaugurated and evaluated a fresh approach including commercial practices to encourage, motivate, and energize technology transfer by: recognizing already successful efforts (Space Technology Hall of Fame Award), drawing potential business and industrial players into the process (Space Commerce Expo), and informing and motivating the general public (Space Technology Hall of Fame public venues). The first year's efforts are documented and directions for the future are outlined.

Propagule pressure determines recruitment from a commercial shipping pier.

PubMed

Hedge, Luke H; Johnston, Emma L

2012-01-01

Artificial structures associated with shipping and boating activities provide habitats for a diverse suite of non-indigenous marine species. Little is known about the proportion of invader success in nearby waters that is attributable to these structures. Areas close to piles, wharves and piers are likely to be exposed to increasing levels of propagule pressure, enhancing the recruitment of non-indigenous species. Recruitment of non-indigenous and native marine biofouling taxa were evaluated at different distances from a large commercial shipping pier. Since artificial structures also represent a desirable habitat for fish, how predation on marine invertebrates influences the establishment of non-indigenous and native species was also evaluated. The colonisation of several non-indigenous marine species declined rapidly with distance from the structure. Little evidence was found to suggest that predators have much influence on the colonisation success of marine sessile invertebrate species, non-indigenous or otherwise. It is suggested that propagule pressure, not predation, more strongly predicts establishment success in these biofouling assemblages.

CVISN business case (commercial vehicle information systems and networks)

DOT National Transportation Integrated Search

2007-10-15

The objective was to evaluate economic justifications and institutional issues affecting motor carriers and State transportation agencies regarding the deployment of CVISN technologies. CVISN (Commercial Vehicle Information Systems and Networks) incl...

Highly pathogenic Eurasian H5N8 avian influenza outbreaks in two commercial poultry flocks in California

USDA-ARS?s Scientific Manuscript database

In January 2015, a highly pathogenic Eurasian lineage H5N8 avian influenza (AI) virus was detected in a commercial meat turkey flock in Stanislaus County, California. Approximately 3 weeks later, a similar case was diagnosed in commercial chickens from a different company located in Kings County, C...

Locating People Diagnosed With HIV for Public Health Action: Utility of HIV Case Surveillance and Other Data Sources.

PubMed

Padilla, Mabel; Mattson, Christine L; Scheer, Susan; Udeagu, Chi-Chi N; Buskin, Susan E; Hughes, Alison J; Jaenicke, Thomas; Wohl, Amy Rock; Prejean, Joseph; Wei, Stanley C

Human immunodeficiency virus (HIV) case surveillance and other health care databases are increasingly being used for public health action, which has the potential to optimize the health outcomes of people living with HIV (PLWH). However, often PLWH cannot be located based on the contact information available in these data sources. We assessed the accuracy of contact information for PLWH in HIV case surveillance and additional data sources and whether time since diagnosis was associated with accurate contact information in HIV case surveillance and successful contact. The Case Surveillance-Based Sampling (CSBS) project was a pilot HIV surveillance system that selected a random population-based sample of people diagnosed with HIV from HIV case surveillance registries in 5 state and metropolitan areas. From November 2012 through June 2014, CSBS staff members attempted to locate and interview 1800 sampled people and used 22 data sources to search for contact information. Among 1063 contacted PLWH, HIV case surveillance data provided accurate telephone number, address, or HIV care facility information for 239 (22%), 412 (39%), and 827 (78%) sampled people, respectively. CSBS staff members used additional data sources, such as support services and commercial people-search databases, to locate and contact PLWH with insufficient contact information in HIV case surveillance. PLWH diagnosed <1 year ago were more likely to have accurate contact information in HIV case surveillance than were PLWH diagnosed ≥1 year ago ( P = .002), and the benefit from using additional data sources was greater for PLWH with more longstanding HIV infection ( P < .001). When HIV case surveillance cannot provide accurate contact information, health departments can prioritize searching additional data sources, especially for people with more longstanding HIV infection.

NREL Quickens its Tech Transfer Efforts

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lammers, H.

2012-02-01

Innovations and 'aha' movements in renewable energy and energy efficiency, while exciting in the lab, only truly live up to their promise once they find a place in homes or business. Late last year President Obama issued a directive to all federal agencies to increase their efforts to transfer technologies to the private sector in order to achieve greater societal and economic impacts of federal research investments. The president's call to action includes efforts to establish technology transfer goals and to measure progress, to engage in efforts to increase the speed of technology transfer and to enhance local and regionalmore » innovation partnerships. But, even before the White House began its initiative to restructure the commercialization process, the National Renewable Energy Laboratory had a major effort underway designed to increase the speed and impact of technology transfer activities and had already made sure its innovations had a streamlined path to the private sector. For the last three years, NREL has been actively setting commercialization goals and tracking progress against those goals. For example, NREL sought to triple the number of innovations over a five-year period that began in 2009. Through best practices associated with inventor engagement, education and collaboration, NREL quadrupled the number of innovations in just three years. Similar progress has been made in patenting, licensing transactions, income generation and rewards to inventors. 'NREL is known nationally for our cutting-edge research and companies know to call us when they are ready to collaborate,' William Farris, vice president for commercialization and technology transfer, said. 'Once a team is ready to dive in, they don't want be mired in paperwork. We've worked to make our process for licensing NREL technology faster; it now takes less than 60 days for us to come to an agreement and start work with a company interested in our research.' While NREL maintains a robust patent portfolio, often companies are looking to do more than just license a technology. These relationships are invaluable in successfully moving technologies from NREL to the marketplace. 'We may generate new and potentially valuable innovations, but our commercialization partners do the heavy work of building a successful business around our technology,' Farris said. Tools such as CRADAs (Cooperative Research and Development Agreements) allow NREL to continue working with companies to refine and develop technologies. And, working with businesses is an area where NREL excels. NREL is responsible for one quarter of the CRADAs in the DOE system. 'When you look at the results of our CRADA program, you can demonstrate that we are actively engaged with companies in collaborating on research and moving technologies to market,' Farris said. NREL is first among DOE labs with 186 active CRADAs. And last year, NREL also was first with the number of new CRADAs signed. 'Part of the success in our working with industry goes back to NREL's mission to grow and support new industries,' Farris added. 'NREL has basic research capabilities, but we are never going to be the ultimate producer of a commercial product. That is the role of the private sector.' Farris also credits the advocacy and support that the Office of Energy Efficiency and Renewable Energy at DOE provides for these technology transfer activities. 'EERE's support is critical to our success,' Farris said. To assist the private sector in moving a technology from the lab to the manufacturing line, NREL has a number of programs in place to give that first, or even final, nudge toward commercialization. For instance, the Commercialization Assistance Program helps startups overcome technical barriers by granting free access to 40 hours of work at the lab. Through the Innovation and Entrepreneurship Center, NREL also helps clean energy businesses develop strong links with the financial community, as well as other key stakeholders in the commercialization process. In March, NREL formally opened the Colorado Center for Renewable Energy and Economic Development a cooperative program with the state of Colorado designed to bring together stakeholders and service providers that support the growth of cleantech companies. CREED currently is working with more than 25 stakeholders - governmental partners, universities, industry associations, venture capital organizations and small businesses - to improve the access these groups have to technologies developed at NREL and to provide services such as classes and workshops for entrepreneurs. When it comes to bringing together cleantech stakeholders, NREL's Industry Growth Forum is the marquee event. At the forum, clean energy entrepreneurs have the opportunity to present their business cases to an expert panel of investors and energy executives. Companies that have presented have raised $3.4 billion in funding to date.« less

Plan to procedure: combining 3D templating with rapid prototyping to enhance pedicle screw placement

NASA Astrophysics Data System (ADS)

Augustine, Kurt E.; Stans, Anthony A.; Morris, Jonathan M.; Huddleston, Paul M.; Matsumoto, Jane M.; Holmes, David R., III; Robb, Richard A.

2010-02-01

Spinal fusion procedures involving the implantation of pedicle screws have steadily increased over the past decade because of demonstrated improvement in biomechanical stability of the spine. However, current methods of spinal fusion carries a risk of serious vascular, visceral, and neurological injury caused by inaccurate placement or inappropriately sized instrumentation, which may lead to patient paralysis or even fatality. 3D spine templating software developed by the Biomedical Imaging Resource (BIR) at Mayo Clinic allows the surgeon to virtually place pedicle screws using pre-operative 3D CT image data. With the template plan incorporated, a patient-specific 3D anatomic model is produced using a commercial rapid prototyping system. The pre-surgical plan and the patient-specific model then are used in the procedure room to provide real-time visualization and quantitative guidance for accurate placement of each pedicle screw, significantly reducing risk of injury. A pilot study was conducted at Mayo Clinic by the Department of Radiology, the Department of Orthopedics, and the BIR, involving seven complicated pediatric spine cases. In each case, pre-operative 3D templating was carried out and patient specific models were generated. The plans and the models were used intra-operatively, providing precise pedicle screw starting points and trajectories. Postoperative assessment by the surgeon confirmed all seven operations were successful. Results from the study suggest that patient-specific, 3D anatomic models successfully acquired from 3D templating tools are valuable for planning and conducting pedicle screw insertion procedures.

Facile fabrication of ultrathin Pt overlayers onto nanoporous metal membranes via repeated Cu UPD and in situ redox replacement reaction.

PubMed

Liu, Pengpeng; Ge, Xingbo; Wang, Rongyue; Ma, Houyi; Ding, Yi

2009-01-06

Ultrathin Pt films from one to several atomic layers are successfully decorated onto nanoporous gold (NPG) membranes by utilizing under potential deposition (UPD) of Cu onto Au or Pt surfaces, followed by in situ redox replacement reaction (RRR) of UPD Cu by Pt. The thickness of Pt layers can be controlled precisely by repeating the Cu-UPD-RRR cycles. TEM observations coupled with electrochemical testing suggest that the morphology of Pt overlayers changes from an ultrathin epitaxial film in the case of one or two atomic layers to well-dispersed nanoislands in the case of four and more atomic layers. Electron diffraction (ED) patterns confirm that the as-prepared NPG-Pt membranes maintain a single-crystalline structure, even though the thickness of Pt films reaches six atomic layers, indicating the decorated Pt films hold the same crystallographic relationship to the NPG substrate during the entire fabrication process. Due to the regular modulation of Pt utilization, the electrocatalytic activity of NPG-Pt exhibits interesting surface structure dependence in methanol, ethanol, and CO electrooxidation reactions. These novel bimetallic nanocatalysts show excellent electrocatalytic activity and much enhanced poison tolerance as compared to the commercial Pt/C catalysts. The success in the fabrication of NPG-Pt-type materials provides a new path to prepare electrocatalysts with ultralow Pt loading and high Pt utilization, which is of great significance in energy-related applications, such as direct alcohol fuel cells (DAFCs).

Oesophageal stent placement to treat a massive iatrogenic duodenal defect after laparoscopic cholecystectomy.

PubMed

Greenbaum, Alissa; Parasher, Gulshan; Demarest, Gerald; Auyang, Edward

2017-05-05

Iatrogenic duodenal injury occurring during laparoscopic cholecystectomy (LC) is managed surgically, though rarely a large, persistent fistula is refractory to surgical interventions. We present the case of a 40-year-old woman transferred to our centre following elective LC for a reported perforated duodenal ulcer. An uncontained leak was found to originate from a 1.5 cm duodenal defect, with no evidence of ulceration. A duodenostomy tube was placed. One month after abdominal closure, the patient continued to have a persistent, large duodenal fistula. A through-the-scope covered oesophageal stent was placed under endoscopic and fluoroscopic guidance. Five weeks later, it was successfully retrieved and no subsequent extravasation of contrast from the duodenum was noted. Unrecognised iatrogenic duodenal injuries sustained during LC can be catastrophic. In cases of massive duodenal defects and high-output biliary fistula uncontrolled after surgical intervention, endoscopic-guided and fluoroscopic-guided placement of a fully covered oesophageal stent may be lifesaving. © BMJ Publishing Group Ltd (unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Water management challenges in the context of agricultural intensification and endemic fluorosis: the case of Yuanmou County.

PubMed

Fang, Jing; Wu, Xinan; Xu, Jianchu; Yang, Xuefei; Song, Xiaoxiao; Wang, Guangan; Yan, Maosheng; Yan, Mei; Wang, Danni

2011-12-01

Yuanmou County in Yunnan Province, China is situated in a dry hot valley where annual evaporation is almost six times the annual rainfall and thus the county suffers from chronic water shortages. Since the early 1980s the county has taken advantage of local warm climate and focused its economic development strategy on commercial vegetable plantations. This strategy successfully brings high income to the local government and farmers, but increases water consumption and adds an extra stressor to the already diminished water resources. Yuanmou County is one of the endemic fluorosis hotspots in China where both dental and skeletal fluorosis cases have been found among local villagers that were diagnosed as being water-borne. Despite measures to adapt to water shortages and control fluorosis taken by the local government and communities, new challenges are emerging. Herein, we describe the water management challenges facing the county as well as document the coping strategies adopted by the government and communities, analyze remaining and emerging challenges, and suggest an ecohealth framework for better management of water resources in Yuanmou.

Sustaining active-living communities over the decades: lessons from a 1930s Greenbelt town.

PubMed

Ahrentzen, Sherry

2008-06-01

Greendale, Wisconsin, was intentionally created with many of the design and planning principles that active-living advocates promote today. This case study examines the processes behind sustaining these particular planning and design principles over time in light of economic and regional challenges that have faced not just Greendale but most town centers over the last fifty years. Despite these challenges, the walkable nature of Greendale's center remains strong today, in terms of both activity and community identity. While many circumstances are specific to this particular town, useful lessons can be drawn for those new urbanist (NU) communities being developed in greenfields and suburbs today, many of which are strikingly similar to Greendale - relatively small, low density, and located within metropolitan areas. Greendale's success resulted from (1) attending to the retail/commercial product mix; (2) attracting nonresidents to use the community's retail and public space; and (3) capitalizing on community investment not simply from residents' organizing efforts but, more important in this case, from corporate community involvement by a Greendale business firm whose interests and values coincided with those of the community.

Microbubbles in macrocysts - Contrast-enhanced ultrasound assisted sclerosant therapy of a congenital macrocystic lymphangioma: a case report.

PubMed

Menendez-Castro, Carlos; Zapke, Maren; Fahlbusch, Fabian; von Goessel, Heiko; Rascher, Wolfgang; Jüngert, Jörg

2017-07-06

Congenital cystic lymphangiomas are benign malformations due to a developmental disorder of lymphatic vessels. Besides surgical excision, sclerosant therapy of these lesions by intracavitary injection of OK-432 (Picibanil®), a lyophilized mixture of group A Streptococcus pyogenes, is a common therapeutical option. For an appropriate application of OK-432, a detailed knowledge about the structure and composition of the congenital cystic lymphangioma is essential. SonoVue® is a commercially available contrast agent commonly used in sonography by intravenous and intracavitary application. Here we report the case of 2 month old male patient with a large thoracic congenital cystic lymphangioma. Preinterventional imaging of the malformation was performed by contrast-enhanced ultrasound after intracavitary application of SonoVue® immediately followed by a successful sclerotherapy with OK-432. Contrast agent-enhanced ultrasound imaging offers a valuable option to preinterventionally clarify the anatomic specifications of a congenital cystic lymphangioma in more detail than by single conventional sonography. By the exact knowledge about the composition and especially about the intercystic communications of the lymphangioma sclerosant therapy becomes safer and more efficient.

An Industrial Ecology Approach to Municipal Solid Waste ...

EPA Pesticide Factsheets

The organic fraction of municipal solid waste provides abundant opportunities for industrial ecology-based symbiotic use. Energy production, economics, and environmental aspects are analyzed for four alternatives based on different technologies: incineration with energy recovery, gasification, anaerobic digestion, and fermentation. In these cases electricity and ethanol are the products considered, but other products and attempts at symbiosis can be made. The four technologies are in various states of commercial development. To highlight their relative complexities some adjustable parameters which are important for the operability of each process are discussed. While these technologies need to be considered for specific locations and circumstances, generalized economic and environmental information suggests relative comparisons for newly conceptualized processes. The results of industrial ecology-based analysis suggest that anaerobic digestion may improve seven emission categories, while fermentation, gasification, and incineration successively improve fewer emissions. A conceptual level analysis indicates that gasification, anaerobic digestion, and fermentation alternatives lead to positive economic results. In each case the alternatives and their assumptions need further analysis for any particular community. Presents information useful for analyzing the sustainability of alternatives for the management of municipal solid waste.

A drunken search in crystallization space

PubMed Central

Fazio, Vincent J.; Peat, Thomas S.; Newman, Janet

2014-01-01

The REMARK280 field of the Protein Data Bank is the richest open source of successful crystallization information. The REMARK280 field is optional and currently uncurated, so significant effort needs to be applied to extract reliable data. There are well over 15 000 crystallization conditions available commercially from 12 different vendors. After putting the PDB crystallization information and the commercial cocktail data into a consistent format, these data are used to extract information about the overlap between the two sets of crystallization conditions. An estimation is made as to which commercially available conditions are most appropriate for producing well diffracting crystals by looking at which commercial conditions are found unchanged (or almost unchanged) in the PDB. Further analyses include which commercial kits are the most appropriate for shotgun or more traditional approaches to crystallization screening. This analysis suggests that almost 40% of the crystallization conditions found currently in the PDB are identical or very similar to a commercial condition. PMID:25286930

Amping it up on a small budget: Transforming inexpensive, commercial audio and video components into a useful charged particle spectrometer

NASA Astrophysics Data System (ADS)

Pallone, Arthur

Necessity often leads to inspiration. Such was the case when a traditional amplifier quit working during the collection of an alpha particle spectrum. I had a 15 battery-powered audio amplifier in my box of project electronics so I connected it between the preamplifier and the multichannel analyzer. The alpha particle spectrum that appeared on the computer screen matched expectations even without correcting for impedance mismatches. Encouraged by this outcome, I have begun to systematically replace each of the parts in a traditional charged particle spectrometer with audio and video components available through consumer electronics stores with the goal of producing an inexpensive charged particle spectrometer for use in education and research. Hopefully my successes, setbacks, and results to date described in this presentation will inform and inspire others.

Economic effects and spin-offs in a small space economy: the case of Canada.

PubMed

Amesse, Fernand; Cohendet, Patrick; Poirier, Alain; Chouinard, Jean-Marc

2002-12-01

Canada, through a well-focused space program (telecommunications, earth observation, robotics), has succeeded in developing a space industry largely based on SMEs. The result has been significant economic benefits and technological spin-offs. In this article, the results of two programs, the ESA (European Space Agency) and the STEAR (Strategic Technologies in Automation and Robotics), are compared. The ESA program has generated significant indirect effects and spin-offs for Canadian exports. ESA's reputation and network have enabled SMEs to increase export sales of both space products and other commercial products derived from space technologies. The STEAR program has been highly successful in promoting a new generation of SMEs for space robotics, encouraging both spin-in and spin-offs of technologies. The analysis highlights the complementarity of mission- and diffusion-oriented programs in the technology transfer process.

A preliminary cost analysis of the biotreatment of refinery spent-sulfidic caustic.

PubMed

Sublette, K L

1997-01-01

Caustics are used in petroleum refining to remove hydrogen sulfide from various hydrocarbon streams. Spent-sulfidic caustics from three refineries have been successfully biotreated on the bench and pilot scale, resulting in neutralization and removal of active Sulfides. Sulfides were completely oxidized to sulfate by Thiobacillus denitrificans strain F. Microbial oxidation of sulfide produced acid, which at least partially neutralized the caustic. A commercial-scale treatment system has been designed that features a bioreactor with a suspended culture of flocculated T. denitrificans, a settler and acid and nutrient storage and delivery systems. A cost analysis has been performed for nine cases representing a range of spent caustic sulfide and hydroxide concentrations at a base treatment rate of 10 gpm. This analysis shows that refinery spent-sulfidic caustic can be biotreated for 4-8.3 cent/gal.

Technology transfer from space to earth - The NASA Firefighter's Breathing System

NASA Technical Reports Server (NTRS)

Mclaughlan, P. B.; Anuskiewicz, T.; Keune, F. A.

1976-01-01

Responding to the recent demand of fire services for a better equipment, NASA has prepared two improved versions of Firefighter's Breathing System (FBS) by taking advantage of the spacesuit design. In the new FBS, the conventional oxygen tube is replaced by a 40% lighter air tube with twice as much pressure. The load is attached to a wide waist belt and distributed on the hips instead of the shoulder, thus making it easier to carry. The two versions of the FBS are essentially the same, the only difference being the capacities of the air tubes. Also the face mask used is smaller, lighter and provides better vision and mobility. The FBS had a notable impact, with the fire departments reporting improved efficiency. Unlike other technology transfer cases, the FBS concept is commercially successful in finding diverse fields of application.

Vented Launch Vehicle Adaptor for a Manned Spacecraft with "Pusher" Launch Abort System

NASA Technical Reports Server (NTRS)

Vandervort, Robert E. (Inventor)

2017-01-01

A system, method, and apparatus for a vented launch vehicle adaptor (LVA) for a manned spacecraft with a "pusher" launch abort system are disclosed. The disclosed LVA provides a structural interface between a commercial crew vehicle (CCV) crew module/service module (CM/SM) spacecraft and an expendable launch vehicle. The LVA provides structural attachment of the module to the launch vehicle. It also provides a means to control the exhaust plume from a pusher-type launch abort system that is integrated into the module. In case of an on-pad or ascent abort, which requires the module to jettison away from the launch vehicle, the launch abort system exhaust plume must be safely directed away from critical and dangerous portions of the launch vehicle in order to achieve a safe and successful jettison.

Strengthening Children’s Advertising Defenses: The Effects of Forewarning of Commercial and Manipulative Intent

PubMed Central

Rozendaal, Esther; Buijs, Laura; van Reijmersdal, Eva A.

2016-01-01

This study investigated whether a forewarning of advertising’s intent can increase children’s (N = 159, 8–10 years old) defenses against television commercials to lower their desire for advertised products. Two different forewarnings were tested, one for advertising’s commercial intent or warning for the promotional nature, and one for advertising’s manipulative intent or warning for the deceptive nature. Results showed that only the warning of manipulative intent prior to advertising exposure was successful in increasing children’s advertising defenses. This forewarning activated children’s attitudinal advertising literacy (i.e., skepticism toward the commercial), which in turn led to lower advertised product desire. The forewarning of commercial intent was not effective in strengthening children’s advertising defenses. These findings have important implications for interventions that aim to lower children’s desire for (unhealthy) advertised products by activating their advertising literacy. PMID:27551271

Crew Transportation System Design Reference Missions

NASA Technical Reports Server (NTRS)

Mango, Edward J.

2015-01-01

Contains summaries of potential design reference mission goals for systems to transport humans to andfrom low Earth orbit (LEO) for the Commercial Crew Program. The purpose of this document is to describe Design Reference Missions (DRMs) representative of the end-to-end Crew Transportation System (CTS) framework envisioned to successfully execute commercial crew transportation to orbital destinations. The initial CTS architecture will likely be optimized to support NASA crew and NASA-sponsored crew rotation missions to the ISS, but consideration may be given in this design phase to allow for modifications in order to accomplish other commercial missions in the future. With the exception of NASA’s mission to the ISS, the remaining commercial DRMs are notional. Any decision to design or scar the CTS for these additional non-NASA missions is completely up to the Commercial Provider. As NASA’s mission needs evolve over time, this document will be periodically updated to reflect those needs.

Detection of low frequency external electronic identification devices using commercial panel readers.

PubMed

Stewart, S C; Rapnicki, P; Lewis, J R; Perala, M

2007-09-01

The ability of a commercially available panel reader system to read International Standards Organization-compliant electronic identification devices under commercial dairy conditions was examined. Full duplex (FDX-B) and half-duplex (HDX) low frequency radio-frequency identification external ear tags were utilized. The study involved 498 Holstein cows in the final 6 wk of gestation. There were 516 total electronic identification devices (n = 334 HDX and n = 182 FDX-B). Eighteen FDX-B were replaced with HDX during the study due to repeated detection failure. There were 6,679 HDX and 3,401 FDX-B device detection attempts. There were 220 (2.2%) unsuccessful and 9,860 (97.8%) successful identification detection attempts. There were 9 unsuccessful detection attempts for HDX (6,670/6,679 = 99.9% successful detection attempts) and 211 unsuccessful detection attempts for FDX-B (3,190/3,401 = 93.8% successful detection attempts). These results demonstrate that this panel system can achieve high detection rates of HDX devices and meet the needs of the most demanding management applications. The FDX-B detection rate was not sufficient for the most demanding applications, requiring a high degree of detection by panel readers. The lower FDX-B rate may not be inherent in the device technology itself, but could be due to other factors, including the particular panel reader utilized or the tuning of the panel reader.

Commercialization of biopharmaceutical knowledge in Iran; challenges and solutions

PubMed Central

2014-01-01

Background The objective of this study was to investigate the application of the university research findings or commercialization of the biopharmaceutical knowledge in Iran and determine the challenges and propose some solutions. Results A qualitative study including 19 in-depth interviews with experts was performed in 2011 and early 2012. National Innovation System (NIS) model was employed as the study design. Thematic method was applied for the analysis. The results demonstrate that policy making, regulations and management development are considered as fundamental reasons for current commercialization practice pattern. It is suggested to establish foundation for higher level documents that would involve relating bodies and provide them operational guidelines for the implementation of commercialization incentives. Conclusions Policy, regulations and management as the most influential issue should be considered for successful commercialization. The present study, for the first time, attempts to disclose the importance of evidence input for measures in order to facilitate the commercialization process by the authorities in Iran. Overall, the NIS model should be considered and utilized as one of the effective solutions for commercialization. PMID:24568555

Injectable controlled release depots for large molecules

PubMed Central

Schwendeman, Steven P.; Shah, Ronak B.; Bailey, Brittany A.; Schwendeman, Anna S.

2014-01-01

Biodegradable, injectable depot formulations for long-term controlled drug release have improved therapy for a number of drug molecules and led to over a dozen highly successful pharmaceutical products. Until now, success has been limited to several small molecules and peptides, although remarkable improvements have been accomplished in some of these cases. For example, twice-a-year depot injections with leuprolide are available compared to the once-a-day injection of the solution dosage form. Injectable depots are typically prepared by encapsulation of the drug in poly(lactic-co-glycolic acid) (PLGA), a polymer that is used in children every day as a resorbable suture material, and therefore, highly biocompatible. PLGAs remain today as one of the few “real world” biodegradable synthetic biomaterials used in US FDA-approved parenteral long-acting-release (LAR) products. Despite their success, there remain critical barriers to the more widespread use of PLGA LAR products, particularly for delivery of more peptides and other large molecular drugs, namely proteins. In this review, we describe key concepts in the development of injectable PLGA controlled-release depots for peptides and proteins, and then use this information to identify key issues impeding greater widespread use of PLGA depots for this class of drugs. Finally, we examine important approaches, particularly those developed in our research laboratory, toward overcoming these barriers to advance commercial LAR development. PMID:24929039

DNA typing of Pakistani cattle breeds Tharparkar and Red Sindhi by microsatellite markers.

PubMed

Azam, Amber; Babar, Masroor Ellahi; Firyal, Sehrish; Anjum, Aftab Ahmad; Akhtar, Nabeela; Asif, Muhammad; Hussain, Tanveer

2012-02-01

Microsatellite markers are used for any individual identity and breed characterization in animals that is an efficient and successful way of investigation. They are used for multiple purposes as genetic detectors including, rapid mutation rate, high level of polymorphism, and range of variety of microsatellite markers available. A panel of 19 microsatellite markers was developed for breed characterization in Tharparkar and Red Sindhi breeds of cattle in Pakistan. Forty four blood samples of cattle (each breed) were collected from Department of Livestock Management, Sindh Agriculture University, Tandojam, Tando Qaiser, Tharparkar Cattle Farm Nabi sar Road, Umer Kot, Sindh, and Govt. Red Sindhi Cattle Breeding Farm, Tando Muhammad Khan Pakistan. Breed characterization was 100% successful. Average PIC, He and Power of Exclusion values were found to be 0.91, 0.62 and 13.28, respectively. Pattern of allelic frequencies of most of the microsatellite markers were clearly distinct between two breeds. As a result of present study a reliable, efficient and very informative panel of microsatellite markers was successfully developed which was capable to interpret individual identity, forensic cases and breed characterization in cattle. This facility is ready to be provided to local cattle breeder at commercial level for DNA testing of cattle. This study will also be highly helpful for breed conservation of cattle. In addition this study can also become a basis to open up new disciplines of animal forensics in Pakistan.

Harmonization based on regulatory science between scientific and commercial radio uses in a case of ultrawideband radio

NASA Astrophysics Data System (ADS)

Kohno, Ryuji; Iinatti, Jari; Sameshima, Keiko

2016-12-01

Harmonization for scientific and commercial radio uses is one of the unsolved problems in academia, industry, and regulatory bodies. The demands for commercial radio, mobile communications, and broadcasting have significantly increased over the past few decades; therefore, interference has become a major concern. There is an increasing need to prevent such interferences, for example, between commercial radio systems and other potentially sensitive radio systems such as those used for radio astronomy or studies. When discussing the fairness in resolving such conflicts, regulatory science may be a useful multidisciplinary approach as it scientifically investigates the advantages and disadvantages of a new application or technology for conflicts between different stakeholders through a mathematical analysis of risks versus benefits of the given technology. Such an analysis enables fair rules or regulations to be made. In this study, we apply the above-mentioned concept to harmonize the scientific and commercial uses of radio. After a brief introduction to regulatory science, a case study about the coexistence between ultrawideband commercial radio systems and radio astronomy is considered. Finally, a proposal by International Union of Radio Science, Japan, to the Science Council of Japan in the Cabinet Office to establish a "Center for Coexistence and Harmonization of Scientific and Commercial Uses of Radio Waves" is explained.

APRA-E: The First Seven Years: A Sampling of Project Outcomes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Williams, Ellen D.

2016-08-23

Since 2009, ARPA-E has funded over 500 potentially transformational energy technology projects. Many of these projects have already demonstrated early indicators of technical and commercial success. ARPA-E has begun the process of analyzing and cataloging some of the agency’s most successful projects. This document is a compilation of the first volume of these impactful technologies.

TENTACLE Multi-Camera Immersive Surveillance System Phase 2

DTIC Science & Technology

2015-04-16

successful in solving the most challenging video analytics problems and taking the advanced research concepts into working systems for end- users in both...commercial, space and military applications. Notable successes include winning the DARPA Urban Challenge , software autonomy to guide the NASA robots (spirit... challenging urban environments. CMU is developing a scalable and extensible architecture, improving search/pursuit/tracking capabilities, and addressing

Internal defect detection success story : industry taps into the Forest Products Laboratory's research capabilities-so can you

Treesearch

John Dramm; Bill Adam

2000-01-01

This presentation discusses a success story of cooperative research and development (R&D) and commercialization of ultrasonic detection technology for locating internal defects in lumber. The R&D work described in this paper is the result of a unique federal laboratory and private sector partnership between the USDA Forest Service, Forest Products Laboratory (...

Integration Methodology For Oil-Free Shaft Support Systems: Four Steps to Success

NASA Technical Reports Server (NTRS)

Howard, Samuel A.; DellaCorte, Christopher; Bruckner, Robert J.

2010-01-01

Commercial applications for Oil-Free turbomachinery are slowly becoming a reality. Micro-turbine generators, highspeed electric motors, and electrically driven centrifugal blowers are a few examples of products available in today's commercial marketplace. Gas foil bearing technology makes most of these applications possible. A significant volume of component level research has led to recent acceptance of gas foil bearings in several specialized applications, including those mentioned above. Component tests identifying such characteristics as load carrying capacity, power loss, thermal behavior, rotordynamic coefficients, etc. all help the engineer design foil bearing machines, but the development process can be just as important. As the technology gains momentum and acceptance in a wider array of machinery, the complexity and variety of applications will grow beyond the current class of machines. Following a robust integration methodology will help improve the probability of successful development of future Oil-Free turbomachinery. This paper describes a previously successful four-step integration methodology used in the development of several Oil-Free turbomachines. Proper application of the methods put forward here enable successful design of Oil-Free turbomachinery. In addition when significant design changes or unique machinery are developed, this four-step process must be considered.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Butler, Nicholas; Watson, Erica E.; Wright, Kyle A.

The Global Threat Reduction Initiative (GTRI) reduces and protects vulnerable nuclear and radiological material located at civilian sites worldwide from sabotage, theft or diversion. The GTRI program has worked successfully with foreign countries to remove and protect nuclear and radioactive materials including high-activity sources used in medical, commercial, and research applications. There are many barriers to successful bilateral cooperation that must be overcome including language, preconceived perceptions, long distances, and different views on the threat and protection requirements. Successful cooperation is often based on relationships and building trusting relationships takes time. In the case of Mexico, GTRI first made contactmore » in 2005. The project then lost momentum and stalled. At the same time, GTRI’s cooperation with the Republic of Colombia was a resounding success resulting in the securing of forty sites; the consolidation of numerous disused/orphan sources at a secure national storage facility; and, the development of a comprehensive approach to security including, inter alia, training and sustainability. The government of Colombia also showcased this comprehensive approach to thirteen Central American and Caribbean countries at a GTRI regional security conference held in Panama in October 2004. Representatives from the Colombian government were aware of GTRI’s interest in initiating cooperation with the Government of Mexico and to facilitate this cooperation, they offered to invite their Mexican counterparts to Colombia to observe its successful cooperation with GTRI. Shortly after that visit, the Government of Mexico agreed to move forward and requested that the cooperative efforts in Mexico be performed in a tripartite manner, leveraging the skills, experience, and resources of the Colombians. As a result, 22 of Mexico’s largest radioactive sites have had security upgrades in place within 18 months of cooperation.« less

Prosthetic Jamming Terminal Device: A Case Study of Untethered Soft Robotics

PubMed Central

Amend, John; Farrell, Todd; Latour, Debra; Martinez, Carlos; Johansson, Jen; McNicoll, Anthony; Wartenberg, Marek; Naseef, Samuel; Hanson, William; Culley, William

2016-01-01

Abstract This article illuminates the major and often overlooked challenge of untethering soft robotic systems through the context of recent work, in which soft robotic gripper technology enabled by jamming of granular media was applied to a prosthetic jamming terminal device (PJTD). The PJTD's technical and market feasibility was evaluated in a pilot study with two upper-limb amputees. A PJTD prototype was tested against a commercial device (Motion Control electric terminal service with a one degree-of-freedom pinching mechanism) using two existing hand function tests: the first quantified the device's speed in picking and placing small blocks and the second evaluated a person's ability to perform activities of daily living (ADLs). The PJTD prototype performed slightly slower than its commercial counterpart in the first test. While both participants successfully completed all the ADLs with both devices in the second test, the commercial device scored marginally higher. Results suggested that PJTD can have potential benefits over existing terminal devices, such as providing the capability to firmly grasp tools due to the ability of PJTD to conform to arbitrary surfaces and reducing compensatory shoulder movements due to its axisymmetric design. Some downsides were that users reported fatigue while operating the PJTD, as most operations require pushing the PJTD against target objects to adequately conform to them. The greatest drawback for the PJTD is also a major roadblock preventing a number of soft robotic research projects from making an impact in real-world applications: pneumatic technology required for operating the PJTD is currently too large and heavy to enable compact untethered operation. PMID:28078196

University Software Ownership and Litigation: A First Examination*

PubMed Central

Rai, Arti K.; Allison, John R.; Sampat, Bhaven N.

2013-01-01

Software patents and university-owned patents represent two of the most controversial intellectual property developments of the last twenty-five years. Despite this reality, and concerns that universities act as “patent trolls” when they assert software patents in litigation against successful commercializers, no scholar has systematically examined the ownership and litigation of university software patents. In this Article, we present the first such examination. Our empirical research reveals that software patents represent a significant and growing proportion of university patent holdings. Additionally, the most important determinant of the number of software patents a university owns is not its research and development (“R&D”) expenditures (whether computer science-related or otherwise) but, rather, its tendency to seek patents in other areas. In other words, universities appear to take a “one size fits all” approach to patenting their inventions. This one size fits all approach is problematic given the empirical evidence that software is likely to follow a different commercialization path than other types of invention. Thus, it is perhaps not surprising that we see a number of lawsuits in which university software patents have been used not for purposes of fostering commercialization, but instead, to extract rents in apparent holdup litigation. The Article concludes by examining whether this trend is likely to continue in the future, particularly given a 2006 Supreme Court decision that appears to diminish the holdup threat by recognizing the possibility of liability rules in patent suits, as well as recent case law that may call into question certain types of software patents. PMID:23750052

The feasibility study of corridor system in the commercial downtown area of winter cities based on behavioural architecture—A case study of Harbin Qiulin commercial area

NASA Astrophysics Data System (ADS)

Li, Lingling; Zhao, Jiaqi

2018-05-01

The commercial centre area is a critical part of urban land and it is public space which integrates shopping, leisure and entertainment. Due to the severe weather, winter cities have some problems such as inconvenient behaviours and lack of commercial vitality in winter. From the perspective of behavioural architecture, this paper adopts several methods of field observation, questionnaire survey, and instrumental measurement to study on the renovation design of Harbin Qiulin commercial area. Through this study, an implementable scheme for adding corridor system to activate commercial vitality in the commercial centre of winter cities has been obtained. It is expected to provide a reference for the commercial area design of winter cities in the future.

AJ26 engine test

NASA Image and Video Library

2011-03-19

A team of engineers from NASA's John C. Stennis Space Center, Orbital Sciences Corporation and Aerojet conduct a successful test of an Aerojet AJ26 rocket engine on March 19. Stennis is testing AJ26 engines for Orbital Sciences to power commercial cargo missions to the International Space Station. Orbital has partnered with NASA through the Commercial Orbital Transportation Services initiative to carry out eight cargo missions to the space station by 2015, using Taurus II rockets.

Titres and cross reactions of commercial antisera for the capsular typing of Klebsiella species.

PubMed Central

Casewell, M W

1975-01-01

Ninety commercially supplied sera for the capsular typing of Klebsiella species were tested in a full chequerboard against 72 type strains. Only four of 144 homologous reactions could not be detected. Of the 6336 possible heterologous reactions, 91 actual cross reactions were found. All positive reactions were titrated and working dilutions deduced. This provides essential information for the successful typing of unknown strains with these sera. PMID:1091662

Optimization of the cultivation conditions for mushroom production with European wild strains of Agaricus subrufescens and Brazilian cultivars.

PubMed

Llarena-Hernández, Carlos R; Largeteau, Michèle L; Ferrer, Nathalie; Regnault-Roger, Catherine; Savoie, Jean-Michel

2014-01-15

The almond mushroom Agaricus subrufescens (formerly Agaricus blazei or Agaricus brasiliensis) is cultivated at commercial level in Brazil and some Asian countries on local substrates and casing mixtures. Despite its tropical origin, A. subrufescens might be a seasonal option for mushroom growers in western countries, where some wild strains have been isolated. For this purpose, cultivation conditions were developed starting from the substrate and casing mixture commonly used for commercial production of the button mushroom Agaricus bisporus in France. The commercial compost, based on wheat straw and horse manure, used for A. bisporus and the casing mixture (peat and limestone) supplemented with fine sand proved efficient to grow A. subrufescens. Increasing the depth of the casing layer improved significantly the yield and time to fruiting. Daily variations in temperature did not markedly modify the yield. Significantly higher mushroom biomass was obtained with three wild European strains compared with three Brazilian cultivars. The very productive wild strain CA438-A gave mushrooms of size and dry matter content comparable to those of a cultivar. Commercial production of A. subrufescens can be developed in western countries on the wheat straw-based substrate commonly used for A. bisporus in these regions, by a simple modification of the casing mixture and maintaining the incubation temperature throughout the crop, which is expected to save energy during summer. Good yields were obtained cultivating European strains under optimised parameters. © 2013 Society of Chemical Industry.

Early access programs: Benefits, challenges, and key considerations for successful implementation

PubMed Central

Patil, Sanjaykumar

2016-01-01

Early access programs, (EAPs) are adopted by an increasing number of pharma companies due to several benefits offered by these programs. EAPs offer ethical, compliant, and controlled mechanisms of access to investigational drugs outside of the clinical trial space and before the commercial launch of the drug, to patients with life-threatening diseases having no treatment options available. In addition to the development of positive relationships with key opinion leaders (KOL), patients, advocacy groups and regulators, the data captured from the implementation of EAPs supports in the formulation of global commercialization strategies. This white paper outlines various circumstances to be considered for the implementation of EAPs named patient programs, the regulatory landscape, the benefits and challenges associated with implementing these programs and the key considerations for their successful implementation. PMID:26955570

Molecular Epidemiology of Streptococcus uberis Clinical Mastitis in Dairy Herds: Strain Heterogeneity and Transmission.

PubMed

Davies, P L; Leigh, J A; Bradley, A J; Archer, S C; Emes, R D; Green, M J

2016-01-01

Multilocus sequence typing was successfully completed on 494 isolates of Streptococcus uberis from clinical mastitis cases in a study of 52 commercial dairy herds over a 12-month period. In total, 195 sequence types (STs) were identified. S. uberis mastitis cases that occurred in different cows within the same herd and were attributed to a common ST were classified as potential transmission events (PTEs). Clinical cases attributed to 35 of the 195 STs identified in this study were classified PTE. PTEs were identified in 63% of the herds. PTE-associated cases, which include the first recorded occurrence of that ST in that herd (index case) and all persistent infections with that PTE ST, represented 40% of all the clinical mastitis cases and occurred in 63% of the herds. PTE-associated cases accounted for >50% of all S. uberis clinical mastitis cases in 33% of the herds. Nine STs (ST-5, -6, -20, -22, -24, -35, -233, -361, and -512), eight of which were grouped within a clonal complex (sharing at least four alleles), were statistically overrepresented (OVR STs). The findings indicate that 38% of all clinical mastitis cases and 63% of the PTEs attributed to S. uberis in dairy herds may be caused by the nine most prevalent strains. The findings suggest that a small subset of STs is disproportionally important in the epidemiology of S. uberis mastitis in the United Kingdom, with cow-to-cow transmission of S. uberis potentially occurring in the majority of herds in the United Kingdom, and may be the most important route of infection in many herds. Copyright © 2015 Davies et al.

Highly suspected cases of salmonellosis in two cats fed with a commercial raw meat-based diet: health risks to animals and zoonotic implications.

PubMed

Giacometti, Federica; Magarotto, Jacopo; Serraino, Andrea; Piva, Silvia

2017-07-24

Feeding raw meat-based diets (RMBD) to companion animals raises public health concerns for both animals and humans. While considerable attention has been paid to bacterial contamination of commercial pet food, few literature studies have investigated foodborne disease in companion animals. Salmonellosis is reported to be infrequent in cats but no known data or studies estimating feline salmonellosis are available or large-scale epidemiological studies assessing Salmonella risk factors. Two highly suspected cases of salmonellosis in two cats fed with a commercial frozen poultry RMBD are presented, for the first time from the same household. The clinical presentation, diagnostics, treatment and follow-up are reported and the zoonotic implications are discussed. This case highlights the health risks posed to both animals and owners by feeding RMBD to pets, and suggests that these risks should be considered by veterinary practitioners.

Sleepiness/fatigue and distraction/inattention as factors for fatal versus nonfatal commercial motor vehicle driver injuries.

PubMed

Bunn, T L; Slavova, S; Struttmann, T W; Browning, S R

2005-09-01

A retrospective population-based case-control study was conducted to determine whether driver sleepiness/fatigue and inattention/distraction increase the likelihood that a commercial motor vehicle collision (CVC) will be fatal. Cases were identified as CVC drivers who died (fatal) and controls were drivers who survived (nonfatal) an injury collision using the Kentucky Collision Report Analysis for Safer Highways (CRASH) electronic database from 1998-2002. Cases and controls were matched on unit type and roadway type. Conditional logistic regression was performed. Driver sleepiness/fatigue, distraction/inattention, age of 51 years of age and older, and nonuse of safety belts increase the odds that a CVC will be fatal. Primary safety belt law enactment and enforcement for all states, commercial vehicle driver education addressing fatigue and distraction and other approaches including decreased hours-of-service, rest breaks and policy changes, etc. may decrease the probability that a CVC will be fatal.

National Space Agencies vs. Commercial Space: Towards Improved Space Safety

NASA Astrophysics Data System (ADS)

Pelton, J.

2013-09-01

Traditional space policies as developed at the national level includes many elements but they are most typically driven by economic and political objectives. Legislatively administered programs apportion limited public funds to achieve "gains" that can involve employment, stimulus to the economy, national defense or other advancements. Yet political advantage is seldom far from the picture.Within the context of traditional space policies, safety issues cannot truly be described as "afterthoughts", but they are usually, at best, a secondary or even tertiary consideration. "Space safety" is often simply assumed to be "in there" somewhere. The current key question is can "safety and risk minimization", within new commercial space programs actually be elevated in importance and effectively be "designed in" at the outset. This has long been the case with commercial aviation and there is at least reasonable hope that this could also be the case for the commercial space industry in coming years. The cooperative role that the insurance industry has now played for centuries in the shipping industry and for decades in aviation can perhaps now play a constructive role in risk minimization in the commercial space domain as well. This paper begins by examining two historical case studies in the context of traditional national space policy development to see how major space policy decisions involving "manned space programs" have given undue primacy to "political considerations" over "safety" and other factors. The specific case histories examined here include first the decision to undertake the Space Shuttle Program (i.e. 1970-1972) and the second is the International Space Station. In both cases the key and overarching decisions were driven by political, schedule and cost considerations, and safety seems absence as a prime consideration. In publicly funded space programs—whether in the United States, Europe, Russia, Japan, China, India or elsewhere—it seems realistic to assume that thiscondition will not change. This seems particularly true for high profile, multi-billion dollar programs.The second part of the paper focuses on new commercial space programs that appear to be undertaken in a less restrictive manner; i.e. outside the constraints of politically-driven national space policies. Here the drivers—even within international consortia—seem to be on reliable performance and commercial return. Since sustained accident-free performance is critical to commercial programs very existence and profitability, the inherent role of safety in commercial space industry would seem clear. The question of prime interest for this paper is whether or not it might be possible for smaller and more focused commercial space entities, free from the constraints of space agency organizational and political constraints, to be more "risk adverse" and thus be more nimble in designing "safe" vehicles? If so how can this "safety first" corporate philosophy and management practice be detected and even objectively measured? Could, in the future, risk reduction at the level of design, quality verification, etc., be objectively measured?

On the way to commercializing plant cell culture platform for biopharmaceuticals: present status and prospect.

PubMed

Xu, Jianfeng; Zhang, Ningning

2014-12-01

Plant cell culture is emerging as an alternative bioproduction system for recombinant pharmaceuticals. Growing plant cells in vitro under controlled environmental conditions allows for precise control over cell growth and protein production, batch-to-batch product consistency and a production process aligned with current good manufacturing practices. With the recent US FDA approval and commercialization of the world's first plant cell-based recombinant pharmaceutical for human use, β-glucocerebrosidase for treatment of Gaucher's disease, a new era has come in which plant cell culture shows high potential to displace some established platform technologies in niche markets. This review updates the progress in plant cell culture processing technology, highlights recent commercial successes and discusses the challenges that must be overcome to make this platform commercially viable.

Amperometric IFN-γ immunosensors with commercially fabricated PCB sensing electrodes.

PubMed

Moschou, Despina; Greathead, Louise; Pantelidis, Panagiotis; Kelleher, Peter; Morgan, Hywel; Prodromakis, Themistoklis

2016-12-15

Lab-on-a-Chip (LoC) technology has the potential to revolutionize medical Point-of-Care diagnostics. Currently, considerable research efforts are focused on innovative production technologies that will make commercial upscaling of lab-on-chip products financially viable. Printed circuit board (PCB) manufacturing techniques have several advantages in this field. In this paper we focus on transferring a complete IFN-γ enzyme-linked immune-sorbent assay (ELISA) onto a commercial PCB electrochemical biosensing platform, We adapted a commercially available ELISA to detect the enzyme product TMB/H2O2 using amperometry, successfully reproducing the colorimetry-obtained ELISA standard curve. The results demonstrate the potential for the integration of these components into an automated, disposable, electronic ELISA Lab-on-PCB diagnostic platform. Copyright © 2016 Elsevier B.V. All rights reserved.

Aphrodisiac Use Associated with HIV Infection in Elderly Male Clients of Low-Cost Commercial Sex Venues in Guangxi, China: A Matched Case-Control Study

PubMed Central

Li, Guojian; Shen, Zhiyong; Zhang, Hongman; Lan, Guanghua; Feng, Xue; Lin, Rui; Abdullah, Abu S.; Wu, Zunyou; Shi, Cynthia X.

2014-01-01

Background Rising HIV infection rates have been observed among elderly people in Guangxi, China. Inexpensive aphrodisiacs are available for purchase in suburban and rural areas. This study aims to investigate the association between aphrodisiac use and increased HIV risk for middle-aged and elderly men in Guangxi. Methods A matched case-control study of aphrodisiac use-associated HIV infection was performed among male subjects over 50 years old who were clients of low-cost commercial sex venues in Guangxi. The cases were defined as clients who were HIV-positive and two controls were selected for each case. The cases and the controls were matched on the visited sex venue, age (±3 years), number of years of purchasing sex (±3 years), and educational attainment. Subjects were interviewed and tested for HIV. Paired t-test or McNemar Chi-squared test were used to compare the characteristics between the cases and controls. A stepwise conditional logistic regression was used to identify risk factors associated with HIV infection. Findings This study enrolled 103 cases and 206 controls. Aphrodisiac use (P = 0.02, odds ratio (OR) = 1.81, 95% CI = 1.08–3.04), never using condom during commercial sex encounter (P = 0.03, odds ratio (OR) = 1.82, 95% CI = 1.08–3.07), and lacking a stable partner (P = 0.03, odds ratio (OR) = 1.76, 95% CI = 1.05–2.98) were found to be risk factors for HIV infection among the study groups. For subjects reporting aphrodisiac use, the frequency of purchasing sex was positively correlated with the frequency of aphrodisiac use (r = 0.3; p = 0.02). Conclusions Aphrodisiac use was significantly associated with increased HIV infection risk in men over 50 years old who purchased commercial sex in the suburban and rural areas of Guangxi. Further research and interventions should address the links between aphrodisiac use, commercial sex work, condom use, and increased HIV transmission. PMID:25286369

Aphrodisiac use associated with HIV infection in elderly male clients of low-cost commercial sex venues in Guangxi, China: a matched case-control study.

PubMed

Tang, Zhenzhu; Wu, Xinghua; Li, Guojian; Shen, Zhiyong; Zhang, Hongman; Lan, Guanghua; Feng, Xue; Lin, Rui; Abdullah, Abu S; Wu, Zunyou; Shi, Cynthia X

2014-01-01

Rising HIV infection rates have been observed among elderly people in Guangxi, China. Inexpensive aphrodisiacs are available for purchase in suburban and rural areas. This study aims to investigate the association between aphrodisiac use and increased HIV risk for middle-aged and elderly men in Guangxi. A matched case-control study of aphrodisiac use-associated HIV infection was performed among male subjects over 50 years old who were clients of low-cost commercial sex venues in Guangxi. The cases were defined as clients who were HIV-positive and two controls were selected for each case. The cases and the controls were matched on the visited sex venue, age (±3 years), number of years of purchasing sex (±3 years), and educational attainment. Subjects were interviewed and tested for HIV. Paired t-test or McNemar Chi-squared test were used to compare the characteristics between the cases and controls. A stepwise conditional logistic regression was used to identify risk factors associated with HIV infection. This study enrolled 103 cases and 206 controls. Aphrodisiac use (P = 0.02, odds ratio (OR) = 1.81, 95% CI = 1.08-3.04), never using condom during commercial sex encounter (P = 0.03, odds ratio (OR) = 1.82, 95% CI = 1.08-3.07), and lacking a stable partner (P = 0.03, odds ratio (OR) = 1.76, 95% CI = 1.05-2.98) were found to be risk factors for HIV infection among the study groups. For subjects reporting aphrodisiac use, the frequency of purchasing sex was positively correlated with the frequency of aphrodisiac use (r = 0.3; p = 0.02). Aphrodisiac use was significantly associated with increased HIV infection risk in men over 50 years old who purchased commercial sex in the suburban and rural areas of Guangxi. Further research and interventions should address the links between aphrodisiac use, commercial sex work, condom use, and increased HIV transmission.

Proceedings of the Second Annual Symposium on Industrial Involvement and Successes in Commercial Space

NASA Technical Reports Server (NTRS)

1991-01-01

The proceedings of the conference are presented. It is proposed that commercial development in space is an important element in the future competitive posture of the industrial nations of the world. The resources and characteristics of space will play a major role in opening a new economic frontier for all the spacefaring nations of the world. Some topics of discussion are as follow: NASA's mission and the role of CCD's; A balanced commercial access to space; Systems for COMET; SPACEHAB; Space Station Freedom; The center for macromolecular crystallography; Center for space power and advanced electronics; and The center for mapping.

Entrepreneurship for Creative Scientists

NASA Astrophysics Data System (ADS)

Parker, Dawood; Raghu, Surya; Brooks, Richard

2018-05-01

Through patenting and commercialization, scientists today can develop their work beyond a publication in a learned journal. Indeed, universities and governments are encouraging today's scientists and engineers to break their research out of the laboratory and into the commercial world. However, doing so is complicated and can be daunting for those more used to a research seminar than a board room. This book, written by experienced scientists and entrepreneurs, deals with businesses started by scientists based on innovation and sets out to clarify for scientists and engineers the steps necessary to take an idea along the path to commercialization and maximise the potential for success, regardless of the path taken.

Isolation and in vitro maintenance of trypanosomes from naturally infected and commercially important Brazilian fish.

PubMed

Lemos, Moara; Souto-Padrón, Thaïs

2014-10-01

Fish trypanosomes are widely distributed in commercially important fish, with high prevalence in some Brazilian species. This study provides the first record of the isolation and in vitro maintenance of trypanosomes from Brazilian fish. We produced 49 trypanosome isolates from naturally infected catfish (Hypostomus affinis and Hypostomus luetkeni), using 9 different culture media (out of 31 tested). Trypanosomes were maintained in culture for at least 15 mo and were successfully cryopreserved. Culture forms-epimastigotes and short trypomastigotes-were capable of dividing in vitro. Our study is an important step in the investigation of ultrastructure, taxonomy, and phylogeny of trypanosomes from commercially important Brazilian fish.

Modulatory Effect of Monochromatic Blue Light on Heat Stress Response in Commercial Broilers.

PubMed

Abdo, Safaa E; El-Kassas, Seham; El-Nahas, Abeer F; Mahmoud, Shawky

2017-01-01

In a novel approach, monochromatic blue light was used to investigate its modulatory effect on heat stress biomarkers in two commercial broiler strains (Ross 308 and Cobb 500). At 21 days old, birds were divided into four groups including one group housed in white light, a second group exposed to blue light, a 3rd group exposed to white light + heat stress, and a 4th group exposed to blue light + heat stress. Heat treatment at 33°C lasted for five h for four successive days. Exposure to blue light during heat stress reduced MDA concentration and enhanced SOD and CAT enzyme activities as well as modulated their gene expression. Blue light also reduced the degenerative changes that occurred in the liver tissue as a result of heat stress. It regulated, though variably, liver HSP70 , HSP90 , HSF1 , and HSF3 gene expression among Ross and Cobb chickens. Moreover, the Cobb strain showed better performance than Ross manifested by a significant reduction of rectal temperature in the case of H + B. Furthermore, a significant linear relationship was found between the lowered rectal temperature and the expression of all HSP genes. Generally, the performance of both strains by most assessed parameters under heat stress is improved when using blue light.

Modulatory Effect of Monochromatic Blue Light on Heat Stress Response in Commercial Broilers

PubMed Central

Abdo, Safaa E.; Mahmoud, Shawky

2017-01-01

In a novel approach, monochromatic blue light was used to investigate its modulatory effect on heat stress biomarkers in two commercial broiler strains (Ross 308 and Cobb 500). At 21 days old, birds were divided into four groups including one group housed in white light, a second group exposed to blue light, a 3rd group exposed to white light + heat stress, and a 4th group exposed to blue light + heat stress. Heat treatment at 33°C lasted for five h for four successive days. Exposure to blue light during heat stress reduced MDA concentration and enhanced SOD and CAT enzyme activities as well as modulated their gene expression. Blue light also reduced the degenerative changes that occurred in the liver tissue as a result of heat stress. It regulated, though variably, liver HSP70, HSP90, HSF1, and HSF3 gene expression among Ross and Cobb chickens. Moreover, the Cobb strain showed better performance than Ross manifested by a significant reduction of rectal temperature in the case of H + B. Furthermore, a significant linear relationship was found between the lowered rectal temperature and the expression of all HSP genes. Generally, the performance of both strains by most assessed parameters under heat stress is improved when using blue light. PMID:28698764

Mobile phone imaging and cloud-based analysis for standardized malaria detection and reporting.

PubMed

Scherr, Thomas F; Gupta, Sparsh; Wright, David W; Haselton, Frederick R

2016-06-27

Rapid diagnostic tests (RDTs) have been widely deployed in low-resource settings. These tests are typically read by visual inspection, and accurate record keeping and data aggregation remains a substantial challenge. A successful malaria elimination campaign will require new strategies that maximize the sensitivity of RDTs, reduce user error, and integrate results reporting tools. In this report, an unmodified mobile phone was used to photograph RDTs, which were subsequently uploaded into a globally accessible database, REDCap, and then analyzed three ways: with an automated image processing program, visual inspection, and a commercial lateral flow reader. The mobile phone image processing detected 20.6 malaria parasites/microliter of blood, compared to the commercial lateral flow reader which detected 64.4 parasites/microliter. Experienced observers visually identified positive malaria cases at 12.5 parasites/microliter, but encountered reporting errors and false negatives. Visual interpretation by inexperienced users resulted in only an 80.2% true negative rate, with substantial disagreement in the lower parasitemia range. We have demonstrated that combining a globally accessible database, such as REDCap, with mobile phone based imaging of RDTs provides objective, secure, automated, data collection and result reporting. This simple combination of existing technologies would appear to be an attractive tool for malaria elimination campaigns.

Mobile phone imaging and cloud-based analysis for standardized malaria detection and reporting

NASA Astrophysics Data System (ADS)

Scherr, Thomas F.; Gupta, Sparsh; Wright, David W.; Haselton, Frederick R.

2016-06-01

Rapid diagnostic tests (RDTs) have been widely deployed in low-resource settings. These tests are typically read by visual inspection, and accurate record keeping and data aggregation remains a substantial challenge. A successful malaria elimination campaign will require new strategies that maximize the sensitivity of RDTs, reduce user error, and integrate results reporting tools. In this report, an unmodified mobile phone was used to photograph RDTs, which were subsequently uploaded into a globally accessible database, REDCap, and then analyzed three ways: with an automated image processing program, visual inspection, and a commercial lateral flow reader. The mobile phone image processing detected 20.6 malaria parasites/microliter of blood, compared to the commercial lateral flow reader which detected 64.4 parasites/microliter. Experienced observers visually identified positive malaria cases at 12.5 parasites/microliter, but encountered reporting errors and false negatives. Visual interpretation by inexperienced users resulted in only an 80.2% true negative rate, with substantial disagreement in the lower parasitemia range. We have demonstrated that combining a globally accessible database, such as REDCap, with mobile phone based imaging of RDTs provides objective, secure, automated, data collection and result reporting. This simple combination of existing technologies would appear to be an attractive tool for malaria elimination campaigns.

Search for technological advantages and commercial success in sensor applications: lessons of industrial trials for fiber multianalyzer technology

NASA Astrophysics Data System (ADS)

McMillan, Norman D.; Baker, M.; O'Neill, M.; Smith, Stuart; Augousti, Andreas T.; Mason, Julian; Ryan, Bernard; Ryan, R. A.

1999-01-01

The multianalyzer is a powerful amplitude modulated fiber optic sensor which is perhaps quite typical of so many sensor innovations in that it is a technology looking for an application. Consequently, a series of collaborations with fruit juice, brewing, distilling, biotechnology and polymer industries were made with the objective of identifying potential applications of the multianalyzer. An assessment of these interactions is made for each of the industrial fields explored, by giving for each, just one positive result from the work. The results are then critically assessed. While these studies have illustrated the universal nature of the technology, in every case, lessons have been drawn of a general nature. This experience in particular underlined the difficulty in acceptance of a fiber based technology in industrial process monitoring, against the backdrop of the conservative practice of industry with long established instrumentation. The hard won experience of this product development has shown the vital important of technologists understanding the difference between the marketing concepts of features, benefits and advantages. Three categories of conclusions are drawn, the technical, the commercial, and finally, conclusions drawn from generalizations of the project by the Kingston partners based on their own independent experience in sensor development involving industrial and medical collaborations.

Wastewater treatment with submerged fixed bed biofilm reactor systems--design rules, operating experiences and ongoing developments.

PubMed

Schlegel, S; Koeser, H

2007-01-01

Wastewater treatment systems using bio-films that grow attached to a support media are an alternative to the widely used suspended growth activated sludge process. Different fixed growth biofilm reactors are commercially used for the treatment of municipal as well as industrial wastewater. In this paper a fairly new fixed growth biofilm system, the submerged fixed bed biofilm reactor (SFBBR), is discussed. SFBBRs are based on aerated submerged fixed open structured plastic media for the support of the biofilm. They are generally operated without sludge recirculation in order to avoid clogging of the support media and problems with the control of the biofilm. Reactor and process design considerations for these reactors are reviewed. Measures to ensure the development and maintenance of an active biofilm are examined. SFBBRs have been applied successfully to small wastewater treatment plants where complete nitrification but no high degree of denitrification is necessary. For the pre-treatment of industrial wastewater the use of SFBBRs is advantageous, especially in cases of wastewater with high organic loading or high content of compounds with low biodegradability. Performance data from exemplary commercial plants are given. Ongoing research and development efforts aim at achieving a high simultaneous total nitrogen (TN) removal of aerated SFBBRs and at improving the efficiency of TN removal in anoxic SFBBRs.

Trauma-Focused Cognitive Behavioral Therapy for Commercially Sexually Exploited Youth.

PubMed

Cohen, Judith A; Mannarino, Anthony P; Kinnish, Kelly

2017-06-01

Commercially sexually exploited children and adolescents ("commercially exploited youth")present numerous clinical challenges that have led some mental health providers to question whether current evidence-based treatments are adequate to address the needs of this population. This paper 1) addresses commonalities between the trauma experiences, responses and treatment challenges of commercially exploited youth and those of youth with complex trauma; 2) highlights the importance of careful assessment to guide case conceptualization and treatment planning for commercially exploited youth; and 3) describes strategies for implementing Trauma-Focused Cognitive Behavioral Therapy for complex trauma specific to these youth.

76 FR 21810 - Defense Federal Acquisition Regulation Supplement; Acquisition of Commercial Items (DFARS Case...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-19

... required to fully and adequately document the contract file regarding the market research performed by the... commercial determination is made before contract award. This determination is based on market research, an...

Advancing neurosurgery through translational research.

PubMed

Lacey, Claire; Sutherland, Garnette

2013-01-01

Every year, the number of published research articles increases significantly. However, many potentially useful ideas are lost in this flood of data. Translational research provides a framework through which investigators or laboratories can maximize the likelihood that the product of their research will be adopted in medical practice. There are 2 recognizable models of translation appropriate for the majority of research: investigator driven and industry enabled. Investigator-driven research has more range because it does not have to consider the profit margin of research, but it is a slow process. The industry-enabled model accelerates the translational research process through the power of industry funding but is interested primarily in products with potential for profit. Two cases are examined to illustrate different methods of partnering with industry. IMRIS is a company founded by investigators to distribute intraoperative magnetic resonance imaging technology based on a movable high-field magnet. It took 7 years for IMRIS to make its first sale, but it is now a successful company. With neuroArm, a surgical robot, investigators decided to sell the intellectual property to an established company to ensure successful global commercialization. Translational research advances medicine by creating and distributing effective solutions to contemporary problems.

[Misoprostol: pathways, mediation and social networks for access to abortion using medication in the context of illegality in the State of Sao Paulo].

PubMed

Arilha, Margareth Martha

2012-07-01

The scope of this article is to discuss the commercialization and use of misoprostol for abortion purposes in the illegal contexts that still persist in Brazil. The information presented was collected through case studies conducted with two young women who aborted using medication - one successfully and one unsuccessfully - and two adult women who have close ties with women who used misoprostol. The study confirms the hypothesis that the diffusion and expansion of the use of misoprostol outside the hospital context is associated with the decision of women who seek lower costs, lower risks to their health and privacy. It also permits examination of the interpretation that this increase in consumption is linked to the inclusion of the medication in a set of goods that are illegally traded in Brazil, in different ways and in different contexts. As a result, women are exposed to different degrees of vulnerability depending directly on the steps taken, types of mediation used and social networks they belong to. These are the ways in which women and men obtain access to the use of misoprostol for abortion, the outcome of which may be successful or not.

An Analysis of NASA Technology Transfer. Degree awarded by Pennsylvania State Univ.

NASA Technical Reports Server (NTRS)

Bush, Lance B.

1996-01-01

A review of previous technology transfer metrics, recommendations, and measurements is presented within the paper. A quantitative and qualitative analysis of NASA's technology transfer efforts is performed. As a relative indicator, NASA's intellectual property performance is benchmarked against a database of over 100 universities. Successful technology transfer (commercial sales, production savings, etc.) cases were tracked backwards through their history to identify the key critical elements that lead to success. Results of this research indicate that although NASA's performance is not measured well by quantitative values (intellectual property stream data), it has a net positive impact on the private sector economy. Policy recommendations are made regarding technology transfer within the context of the documented technology transfer policies since the framing of the Constitution. In the second thrust of this study, researchers at NASA Langley Research Center were surveyed to determine their awareness of, attitude toward, and perception about technology transfer. Results indicate that although researchers believe technology transfer to be a mission of the Agency, they should not be held accountable or responsible for its performance. In addition, the researchers are not well educated about the mechanisms to perform, or policies regarding, technology transfer.

Find and treat or find and lose? Tuberculosis treatment outcomes among screened newly arrived asylum seekers in Germany 2002 to 2014.

PubMed

Kuehne, Anna; Hauer, Barbara; Brodhun, Bonita; Haas, Walter; Fiebig, Lena

2018-03-01

BackgroundGermany has a low tuberculosis (TB) incidence. A relevant and increasing proportion of TB cases is diagnosed among asylum seekers upon screening. Aim: We aimed to assess whether cases identified by screening asylum seekers had equally successful and completely reported treatment outcomes as cases diagnosed by passive case finding and contact tracing in the general population. Methods: We analysed characteristics and treatment outcomes of pulmonary TB cases notified in Germany between 2002 and 2014, stratified by mode of case finding. We performed three multivariable analyses with different dependent variables: Model A: successful vs all other outcomes, Model B: successful vs documented non-successful clinical outcome and Model C: known outcome vs lost to follow-up. Results: TB treatment success was highest among cases identified by contact tracing (87%; 3,139/3,591), followed by passive case finding (74%; 28,804/39,019) and by screening asylum seekers (60%; 884/1,474). Cases identified by screening asylum seekers had 2.4 times higher odds of not having a successful treatment outcome as opposed to all other outcomes (A), 1.4 times higher odds of not having a successful treatment outcome as opposed to known non-successful outcomes (B) and 2.3 times higher odds of loss to follow-up (C) than cases identified by passive case finding. Conclusion: Screened asylum seekers had poorer treatment outcomes and were more often lost to follow-up. Linking patients to treatment facilities and investigating potential barriers to treatment completion are needed to secure screening benefits for asylum seekers and communities.

Succession of the turkey gastrointestinal bacterial microbiome related to weight gain.

PubMed

Danzeisen, Jessica L; Calvert, Alamanda J; Noll, Sally L; McComb, Brian; Sherwood, Julie S; Logue, Catherine M; Johnson, Timothy J

2013-12-23

Because of concerns related to the use of antibiotics in animal agriculture, antibiotic-free alternatives are greatly needed to prevent disease and promote animal growth. One of the current challenges facing commercial turkey production in Minnesota is difficulty obtaining flock average weights typical of the industry standard, and this condition has been coined "Light Turkey Syndrome" or LTS. This condition has been identified in Minnesota turkey flocks for at least five years, and it has been observed that average flock body weights never approach their genetic potential. However, a single causative agent responsible for these weight reductions has not been identified despite numerous efforts to do so. The purpose of this study was to identify the bacterial community composition within the small intestines of heavy and light turkey flocks using 16S rRNA sequencing, and to identify possible correlations between microbiome and average flock weight. This study also sought to define the temporal succession of bacteria occurring in the turkey ileum. Based upon 2.7 million sequences across nine different turkey flocks, dominant operational taxonomic units (OTUs) were identified and compared between the flocks studied. OTUs that were associated with heavier weight flocks included those with similarity to Candidatus division Arthromitus and Clostridium bartlettii, while these flocks had decreased counts of several Lactobacillus species compared to lighter weight flocks. The core bacterial microbiome succession in commercial turkeys was also defined. Several defining markers of microbiome succession were identified, including the presence or abundance of Candidatus division Arthromitus, Lactobacillus aviarius, Lactobacillus ingluviei, Lactobacillus salivarius, and Clostridium bartlettii. Overall, the succession of the ileum bacterial microbiome in commercial turkeys proceeds in a predictable manner. Efforts to prevent disease and promote growth in the absence of antibiotics could involve target dominant bacteria identified in the turkey ileum that are associated with increased weight gain.

Succession of the turkey gastrointestinal bacterial microbiome related to weight gain

PubMed Central

Danzeisen, Jessica L.; Calvert, Alamanda J.; Noll, Sally L.; McComb, Brian; Sherwood, Julie S.; Logue, Catherine M.

2013-01-01

Because of concerns related to the use of antibiotics in animal agriculture, antibiotic-free alternatives are greatly needed to prevent disease and promote animal growth. One of the current challenges facing commercial turkey production in Minnesota is difficulty obtaining flock average weights typical of the industry standard, and this condition has been coined “Light Turkey Syndrome” or LTS. This condition has been identified in Minnesota turkey flocks for at least five years, and it has been observed that average flock body weights never approach their genetic potential. However, a single causative agent responsible for these weight reductions has not been identified despite numerous efforts to do so. The purpose of this study was to identify the bacterial community composition within the small intestines of heavy and light turkey flocks using 16S rRNA sequencing, and to identify possible correlations between microbiome and average flock weight. This study also sought to define the temporal succession of bacteria occurring in the turkey ileum. Based upon 2.7 million sequences across nine different turkey flocks, dominant operational taxonomic units (OTUs) were identified and compared between the flocks studied. OTUs that were associated with heavier weight flocks included those with similarity to Candidatus division Arthromitus and Clostridium bartlettii, while these flocks had decreased counts of several Lactobacillus species compared to lighter weight flocks. The core bacterial microbiome succession in commercial turkeys was also defined. Several defining markers of microbiome succession were identified, including the presence or abundance of Candidatus division Arthromitus, Lactobacillus aviarius, Lactobacillus ingluviei, Lactobacillus salivarius, and Clostridium bartlettii. Overall, the succession of the ileum bacterial microbiome in commercial turkeys proceeds in a predictable manner. Efforts to prevent disease and promote growth in the absence of antibiotics could involve target dominant bacteria identified in the turkey ileum that are associated with increased weight gain. PMID:24432198

High success rates of sedation-free brain MRI scanning in young children using simple subject preparation protocols with and without a commercial mock scanner–the Diabetes Research in Children Network (DirecNet) experience

PubMed Central

Barnea-Goraly, Naama; Weinzimer, Stuart A.; Mauras, Nelly; Beck, Roy W.; Marzelli, Matt J.; Mazaika, Paul K.; Aye, Tandy; White, Neil H.; Tsalikian, Eva; Fox, Larry; Kollman, Craig; Cheng, Peiyao; Reiss, Allan L.

2013-01-01

Background The ability to lie still in an MRI scanner is essential for obtaining usable image data. To reduce motion, young children are often sedated, adding significant cost and risk. Objective We assessed the feasibility of using a simple and affordable behavioral desensitization program to yield high-quality brain MRI scans in sedation-free children. Materials and methods 222 children (4–9.9 years), 147 with type 1 diabetes and 75 age-matched non-diabetic controls, participated in a multi-site study focused on effects of type 1 diabetes on the developing brain. T1-weighted and diffusion-weighted imaging (DWI) MRI scans were performed. All children underwent behavioral training and practice MRI sessions using either a commercial MRI simulator or an inexpensive mock scanner consisting of a toy tunnel, vibrating mat, and video player to simulate the sounds and feel of the MRI scanner. Results 205 children (92.3%), mean age 7±1.7 years had high-quality T1-W scans and 174 (78.4%) had high-quality diffusion-weighted scans after the first scan session. With a second scan session, success rates were 100% and 92.5% for T1-and diffusion-weighted scans, respectively. Success rates did not differ between children with type 1 diabetes and children without diabetes, or between centers using a commercial MRI scan simulator and those using the inexpensive mock scanner. Conclusion Behavioral training can lead to a high success rate for obtaining high-quality T1-and diffusion-weighted brain images from a young population without sedation. PMID:24096802

Expandable metal stents for endoscopic bilateral stent-within-stent placement for malignant hilar biliary obstruction.

PubMed

Chahal, Prabhleen; Baron, Todd H

2010-01-01

Placement of biliary stents is effective for palliation of unresectable hilar malignant biliary obstruction. However, when bilateral self-expandable metal stents (SEMSs) are used, placement can be technically challenging. In many studies, side-by-side placement is performed, although it is unclear whether this is the most anatomical and functional approach. We sought to assess the technical feasibility and effectiveness of deploying bilateral SEMSs with a stent-within-stent approach using commercially available stents with a large cell width. Retrospective study. Tertiary care medical center. Patients with malignant biliary hilar obstruction referred for endoscopic palliation of obstructive jaundice. Technical success, ie, successful bilateral SEMS placement across the stricture; functional success, ie, decrease in pretreatment bilirubin level; early and late complications; and stent patency. Bilateral biliary drainage was attempted and successfully established in 21 patients with malignant hilar obstruction (15 men, 6 women; mean age 63.7 [standard deviation 13.9] years), resulting in clinical improvement of obstructive symptoms. Median follow-up was 6.14 months (interquartile range 3.5-9.5 months). There were 1 (5%) early and 7 (33%) late stent occlusions that required endoscopic reintervention. The 30-day mortality rate was 10% (2 deaths). Retrospective study of a series of cases treated at a tertiary care center by expert endoscopists. This simple technique was performed by using an open-cell expandable metal stent is technically feasible and easy and allows bilateral placement of SEMSs in patients with unresectable hilar malignancy. 2010 American Society for Gastrointestinal Endoscopy. Published by Mosby, Inc. All rights reserved.

Ablator Response Model Development: From Flight Data Back to Fundamental Experiments

NASA Technical Reports Server (NTRS)

Mansour, Nagi N.; Lachaud, Jean R.

2013-01-01

The successful Mars atmospheric entry by the Mars Science Laboratory (MSL-Curiosity) combined with the success of the Earth atmospheric entry by the Stardust capsule have established PICA as a major Thermal Protection Systems (TPS) material. We expect that this class of materials will be on the short list selected by NASA for any atmospheric entry missions and that it will be the lead of that list of materials in any planning, feasibility studies or flight readiness studies. In addition to NASAs successes, the Dragon capsule, the successful commercial space vehicle built by SpaceX, uses PICA-X, while the European Space Agency is considering ASTERM for its exploration missions that involve atmospheric entries, both of these materials are of the same family as PICA. In the talk, a high-fidelity model will be detailed and discussed. The model tracks the chemical composition of the gases produced during pyrolysis. As in the conventional models, it uses equilibrium chemistry to determine the recession rate at high temperatures but switches to in-volume finite-rate ablation for lower temperatures. It also tracks the time evolution of the porosity of the material. Progress in implementing this high-fidelity model in a code will be presented. In addition, a set of basic experimental data being supported for model validation will be summarized. The validation process for the model development will be discussed. Preliminary results will be presented for a case where detailed pyrolysis product chemistry is computed. Finally, a wish list for a set of validation experiments will be outlined and discussed.

Avenues and incentives for commercial use of a low-gravity environment

NASA Technical Reports Server (NTRS)

Brown, R. L.; Zoller, L. K.

1981-01-01

The scientific and commercial utilization of the low-g environments for materials research and for process and product development is considered. Any products of commercial interest which necessitate processing in space will probably be low volume, high value items. To encourage the commercialization of materials processing in low-g, NASA, in parallel with establishing and demonstrating the scientific/technological precepts for analyzing and using a low-g environment, is establishing the legal and management mechanisms to share in the cost and risk of early commercial ventures, and is now working with commercial firms on a case-by basis to explore applications of this new technology to specific needs of the company.

Equine Vaccines: How, When and Why? Report of the Vaccinology Session, French Equine Veterinarians Association, 2016, Reims.

PubMed

Paillot, Romain; Marcillaud Pitel, Christel; D'Ablon, Xavier; Pronost, Stéphane

2017-12-04

To date, vaccination is one of the most efficient methods of prevention against equine infectious diseases. The vaccinology session, which was organised during the annual meeting of the French Equine Veterinarians Association (AVEF) at Reims (France) in 2016, aimed to approach three subjects of importance for the equine industry. Vaccination against three major equine diseases were used as examples: equine influenza (equine influenza virus), rhinopneumonitis (equine herpes virus 1/4), and tetanus ( Clostridium tetani neuro-toxin). (1) Emergency vaccination: while it has been very successful to reduce the impact of equine influenza epizooties and it is also recommended for tetanus in case of surgery and accident, the benefit of emergency vaccination against equine herpes virus 1/4 remains arguable; (2) Compatibility of equine vaccines from different brands: despite being a frequent concerns for equine veterinarians, little information is available about the compatibility of equine vaccines from different commercial origins. The consequence of mixing different equine vaccines targeting the same disease is believed to be limited but scientific evidences are sparse; and, (3) Laps vaccination and vaccine shortage: they could have serious consequences in terms of protection and their impact should be evaluated on a case by case basis, taking into account the risk of contact with the pathogen and the effect on herd immunity.

Recent advances towards development and commercialization of plant cell culture processes for synthesis of biomolecules

PubMed Central

Wilson, Sarah A.; Roberts, Susan C.

2011-01-01

(1) Summary Plant cell culture systems were initially explored for use in commercial synthesis of several high value secondary metabolites, allowing for sustainable production that was not limited by the low yields associated with natural harvest or the high cost associated with complex chemical synthesis. Although there have been some commercial successes, most notably paclitaxel production from Taxus sp., process limitations exist with regards to low product yields and inherent production variability. A variety of strategies are being developed to overcome these limitations including elicitation strategies, in situ product removal and metabolic engineering with single genes and transcription factors. Recently, the plant cell culture production platform has been extended to pharmaceutically active heterologous proteins. Plant systems are beneficial because they are able to produce complex proteins that are properly glycosylated, folded and assembled without the risk of contamination by toxins that are associated with mammalian or microbial production systems. Additionally, plant cell culture isolates transgenic material from the environment, allows for more controllable conditions over field grown crops and promotes secretion of proteins to the medium, reducing downstream purification costs. Despite these benefits, the increase in cost of heterologous protein synthesis in plant cell culture as opposed to field grown crops is significant and therefore processes must be optimized with regards to maximizing secretion and enhancing protein stability in the cell culture media. This review discusses recent advancements in plant cell culture processing technology, focusing on progress towards overcoming the problems associated with commercialization of these production systems and highlighting recent commercial successes. PMID:22059985

Commercial tree species discrimination using airborne AISA Eagle hyperspectral imagery and partial least squares discriminant analysis (PLS-DA) in KwaZulu-Natal, South Africa

NASA Astrophysics Data System (ADS)

Peerbhay, Kabir Yunus; Mutanga, Onisimo; Ismail, Riyad

2013-05-01

Discriminating commercial tree species using hyperspectral remote sensing techniques is critical in monitoring the spatial distributions and compositions of commercial forests. However, issues related to data dimensionality and multicollinearity limit the successful application of the technology. The aim of this study was to examine the utility of the partial least squares discriminant analysis (PLS-DA) technique in accurately classifying six exotic commercial forest species (Eucalyptus grandis, Eucalyptus nitens, Eucalyptus smithii, Pinus patula, Pinus elliotii and Acacia mearnsii) using airborne AISA Eagle hyperspectral imagery (393-900 nm). Additionally, the variable importance in the projection (VIP) method was used to identify subsets of bands that could successfully discriminate the forest species. Results indicated that the PLS-DA model that used all the AISA Eagle bands (n = 230) produced an overall accuracy of 80.61% and a kappa value of 0.77, with user's and producer's accuracies ranging from 50% to 100%. In comparison, incorporating the optimal subset of VIP selected wavebands (n = 78) in the PLS-DA model resulted in an improved overall accuracy of 88.78% and a kappa value of 0.87, with user's and producer's accuracies ranging from 70% to 100%. Bands located predominantly within the visible region of the electromagnetic spectrum (393-723 nm) showed the most capability in terms of discriminating between the six commercial forest species. Overall, the research has demonstrated the potential of using PLS-DA for reducing the dimensionality of hyperspectral datasets as well as determining the optimal subset of bands to produce the highest classification accuracies.

Transportation Research | NREL

Science.gov Websites

successes and awards: batteries and energy storage | climate control | commercial vehicle technologies Energy Follow NREL × NREL Blows Up Batteries to Make the World Safer Learn More about NREL's Energy

Electronic credentialing for commercial vehicle operations : a cross-cutting analysis

DOT National Transportation Integrated Search

1999-06-10

This case study presents an analysis of how Maryland, Virginia, and Kentucky have used the Commercial Vehicle Information Systems & Networks (CVISN) Architecture to develop state CVISN systems designs for electronic credentialing. Focus is on the CVI...

[Study on HIV-1 subtype among elderly male clients and female sex workers of low-cost venues in Guangxi Zhuang Autonomous Region, China].

PubMed

Deng, Y Q; Li, J J; Fang, N Y; Wang, B; Wang, J W; Liang, S S; Shen, Z Y; Lan, G H; Zhang, H M; Wu, X H; Lu, H X; Ge, X M

2017-03-10

Objective: To understand HIV-1 subtype characteristics and transmission clusters in elderly male clients and female sex workers (FSWs) of low-cost commercial sex venues in Guangxi Zhuang Autonomous Region, China. Methods: A cross sectional survey was conducted in FSWs and elderly male clients (≥50 years) of low-cost commercial sex venues in 4 cities and 9 counties in Guangxi Zhuang Autonomous Region by convenient sampling in 2012. The blood sample was collected from each case for HIV-1 antibody detection. The pol gene fragments were amplified and sequenced from viral RNA template extracted from plasma samples. The phylogenetic tree was constructed and the subtypes were identified. Results: A total of 4 048 elderly male clients and 784 FSWs were surveyed, and 116 HIV-1 infections were detected, the positive rate was 2.5% (103/4 048) in the clients and 1.7% (13/784) in FSWs. The gene amplification and sequencing of HIV-1 detected in 84 blood samples indicated that 53 pol gene sequences were successfully determined (48 blood samples from elderly male clients and 5 blood samples from FSWs). Among 53 pol sequences, 48(90.6% ), 4(7.5% ), and 1(1.9% ) sequences were identified as CRF01_AE, CRF08_BC, and CRF07_BC, respectively. Two transmission clusters were identified among CRF01_AE, including 4 sub-clusters. One transmission cluster was identified among CRF08_BC. The transmission cluster or sub-cluster were from the infected individuals at same low-cost commercial sex venue, or different low-cost commercial sex venues in the same town, or same place, or adjacent villages and towns. Conclusions: CRF01_AE was the predominant HIV-1 subtype among elderly male clients and FSWs of low-cost commercial sex venues in Guangxi Zhuang Autonomous Region, circulating in same venue or adjacent villages and towns. The HIV-1 positive male clients and FSWs might play an important role in the spread of the strains.

Civil Servants and Contract Employees: Who Should Do What for the Federal Government?

DTIC Science & Technology

1981-06-19

they us Government employees to provide commercial services that contracto could provide in many cases at a lower cost . GAO recommends that the...copies of GAO reports should be sent to: U.S. General Accounting Office Document Handling and Information Services Facility P.O. Box 6015...commercial services that con- tractors could provide in many cases at a lower cost . Although it has been the executive branch’s general policy since 1955 to

WE-D-18A-01: Evaluation of Three Commercial Metal Artifact Reduction Methods for CT Simulations in Radiation Therapy Treatment Planning

DOE Office of Scientific and Technical Information (OSTI.GOV)

Huang, J; Kerns, J; Nute, J

Purpose: To evaluate three commercial metal artifact reduction methods (MAR) in the context of radiation therapy treatment planning. Methods: Three MAR strategies were evaluated: Philips O-MAR, monochromatic imaging using Gemstone Spectral Imaging (GSI) dual energy CT, and monochromatic imaging with metal artifact reduction software (GSIMARs). The Gammex RMI 467 tissue characterization phantom with several metal rods and two anthropomorphic phantoms (pelvic phantom with hip prosthesis and head phantom with dental fillings), were scanned with and without (baseline) metals. Each MAR method was evaluated based on CT number accuracy, metal size accuracy, and reduction in the severity of streak artifacts. CTmore » number difference maps between the baseline and metal scan images were calculated, and the severity of streak artifacts was quantified using the percentage of pixels with >40 HU error (“bad pixels”). Results: Philips O-MAR generally reduced HU errors in the RMI phantom. However, increased errors and induced artifacts were observed for lung materials. GSI monochromatic 70keV images generally showed similar HU errors as 120kVp imaging, while 140keV images reduced errors. GSI-MARs systematically reduced errors compared to GSI monochromatic imaging. All imaging techniques preserved the diameter of a stainless steel rod to within ±1.6mm (2 pixels). For the hip prosthesis, O-MAR reduced the average % bad pixels from 47% to 32%. For GSI 140keV imaging, the percent of bad pixels was reduced from 37% to 29% compared to 120kVp imaging, while GSI-MARs further reduced it to 12%. For the head phantom, none of the MAR methods were particularly successful. Conclusion: The three MAR methods all improve CT images for treatment planning to some degree, but none of them are globally effective for all conditions. The MAR methods were successful for large metal implants in a homogeneous environment (hip prosthesis) but were not successful for the more complicated case of dental artifacts.« less

Commercialization of microfluidic devices.

PubMed

Volpatti, Lisa R; Yetisen, Ali K

2014-07-01

Microfluidic devices offer automation and high-throughput screening, and operate at low volumes of consumables. Although microfluidics has the potential to reduce turnaround times and costs for analytical devices, particularly in medical, veterinary, and environmental sciences, this enabling technology has had limited diffusion into consumer products. This article analyzes the microfluidics market, identifies issues, and highlights successful commercialization strategies. Addressing niche markets and establishing compatibility with existing workflows will accelerate market penetration. Copyright © 2014 Elsevier Ltd. All rights reserved.

Marketing and commercialization of computational research services.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Toevs, J. W.

Physical and computational scientists and mathematicians in Russia's nuclear cities are turning their work toward generating profits from Western markets. Successful ventures require an understanding of the marketing of contract research as well as Western expectations regarding contract execution, quality, and performance. This paper will address fundamentals in business structure, marketing, and contract performance for organizations engaging in the marketing and commercialization of research services. Considerable emphasis will be placed on developing adequate communication within the organization.

Demonstration of Enabling Spar-Shell Cooling Technology in Gas Turbines

DOE Office of Scientific and Technical Information (OSTI.GOV)

Downs, James

2014-12-29

In this Advanced Turbine Program-funded Phase III project, Florida Turbine Technologies, Inc. (FTT) has developed and tested, at a pre-commercial prototypescale, spar-shell turbine airfoils in a commercial gas turbine. The airfoil development is based upon FTT’s research and development to date in Phases I and II of Small Business Innovative Research (SBIR) grants. During this program, FTT has partnered with an Original Equipment Manufacturer (OEM), Siemens Energy, to produce sparshell turbine components for the first pre-commercial prototype test in an F-Class industrial gas turbine engine and has successfully completed validation testing. This project will further the commercialization of this newmore » technology in F-frame and other highly cooled turbine airfoil applications. FTT, in cooperation with Siemens, intends to offer the spar-shell vane as a first-tier supplier for retrofit applications and new large frame industrial gas turbines. The market for the spar-shell vane for these machines is huge. According to Forecast International, 3,211 new gas turbines units (in the >50MW capacity size range) will be ordered in ten years from 2007 to 2016. FTT intends to enter the market in a low rate initial production. After one year of successful extended use, FTT will quickly ramp up production and sales, with a target to capture 1% of the market within the first year and 10% within 5 years (2020).« less

Beyond Yellow Curry: Assessing Commercial Curcumin Absorption Technologies

PubMed Central

Douglass, Brad J.; Clouatre, Dallas L.

2015-01-01

BACKGROUND: Few natural products have demonstrated the range of protective and therapeutic promise as have turmeric and its principal bioactive components: curcumin, demethoxycurcumin, and bisdemethoxycurcumin. Success in translating this potential into tangible benefits has been limited by inherently poor intestinal absorption, rapid metabolism, and limited systemic bioavailability. Seeking to overcome these limitations, food ingredient formulators have begun to employ a variety of approaches to enhance absorption and bioactivity. Many of these strategies improve upon the age-old practice of consuming turmeric in fat-based sauces, such as in a fat-rich yellow curry. However, there exists uncertainty as to how the various commercially available offerings compare to each other in terms of either uptake or efficacy, and this uncertainty leaves physicians and nutritionists with a dearth of data for making recommendations to interested patients and consumers. Further complicating the issue are recent data suggesting that formulation strategies may not equally enhance the absorption of individual curcuminoids, a significant issue in that these curcuminoids exhibit somewhat different physiologic properties. OBJECTIVE: This review introduces needed order to the curcumin marketplace by examining bioavailability studies on a number of commercial curcumin ingredients and evaluating them on a level playing field. METHODS: The comparative analysis includes standard pharmacokinetic parameters and a new metric, relative mass efficiency (E). Relative mass efficiency allows for the comparison of different formulations even in cases in which the weight percentage of curcuminoids is vastly different. RESULTS: A hydrophilic carrier dispersed curcuminoid formula exhibits 45.9 times the bioavailability of the standard purified 95 percent curcuminoid preparation and, based on relative mass efficiency, 1.5 times the bioavailability of the next best commercial ingredient, a cyclodextrin complex. CONCLUSIONS: Delivery strategies can significantly improve the bioavailability of curcuminoids. Total formula mass is important for making practical formulation decisions about dosing, cost and space. PMID:25856323

Utility of a Work Process Classification System for characterizing non-fatal injuries in the Alaskan commercial fishing industry

PubMed Central

Syron, Laura N.; Lucas, Devin L.; Bovbjerg, Viktor E.; Bethel, Jeffrey W.; Kincl, Laurel D.

2016-01-01

Background The US commercial fishing industry is hazardous, as measured by mortality data. However, research on non-fatal injuries is limited. Non-fatal injuries constitute the majority of occupational injuries and can result in workers’ lowered productivity and wages, lost quality of life, and disability. In the United States, a Work Process Classification System (WPCS) has previously been applied in Alaskan freezer-trawl and freezer-longline fleets to identify causes of injuries and specific hazards, but not to other fishing fleets. Objectives This descriptive epidemiologic study aimed to explore the application and modification of the WPCS in multiple Alaskan fleets, characterize non-fatal occupational injuries in these fleets, and identify work processes that could be targeted for further investigation and future injury prevention efforts. Design Traumatic, non-fatal injuries on-board Alaskan commercial fishing vessels were identified through United States Coast Guard investigative reports. Characteristics of injuries, as well as worker characteristics, were analysed. Injuries were coded using the WPCS. Results We successfully utilized the WPCS to code non-fatal injury cases (n = 136). The most frequent main work processes associated with non-fatal injuries included: on-board trawlers, handling frozen fish and processing the catch; on-board vessels using pot/trap gear, handling the gear and shooting/setting the gear; on-board longliners, traffic on board and hauling the gear; and on-board processor vessels, processing the catch, other work with the catch, and handling frozen fish. Conclusions The study confirmed that a WPCS can be applied to multiple Alaskan fleets to identify hazardous tasks. Hazards were unique for each vessel gear type. Future injury prevention efforts should target work processes associated with the most frequent and most severe injuries. Future studies should establish time estimates for work processes in order to determine risk estimates. Efforts to improve non-fatal injury reporting, especially on smaller commercial fishing vessels, should be undertaken. PMID:26782030

Utility of a Work Process Classification System for characterizing non-fatal injuries in the Alaskan commercial fishing industry.

PubMed

Syron, Laura N; Lucas, Devin L; Bovbjerg, Viktor E; Bethel, Jeffrey W; Kincl, Laurel D

2016-01-01

Background The US commercial fishing industry is hazardous, as measured by mortality data. However, research on non-fatal injuries is limited. Non-fatal injuries constitute the majority of occupational injuries and can result in workers' lowered productivity and wages, lost quality of life, and disability. In the United States, a Work Process Classification System (WPCS) has previously been applied in Alaskan freezer-trawl and freezer-longline fleets to identify causes of injuries and specific hazards, but not to other fishing fleets. Objectives This descriptive epidemiologic study aimed to explore the application and modification of the WPCS in multiple Alaskan fleets, characterize non-fatal occupational injuries in these fleets, and identify work processes that could be targeted for further investigation and future injury prevention efforts. Design Traumatic, non-fatal injuries on-board Alaskan commercial fishing vessels were identified through United States Coast Guard investigative reports. Characteristics of injuries, as well as worker characteristics, were analysed. Injuries were coded using the WPCS. Results We successfully utilized the WPCS to code non-fatal injury cases (n = 136). The most frequent main work processes associated with non-fatal injuries included: on-board trawlers, handling frozen fish and processing the catch; on-board vessels using pot/trap gear, handling the gear and shooting/setting the gear; on-board longliners, traffic on board and hauling the gear; and on-board processor vessels, processing the catch, other work with the catch, and handling frozen fish. Conclusions The study confirmed that a WPCS can be applied to multiple Alaskan fleets to identify hazardous tasks. Hazards were unique for each vessel gear type. Future injury prevention efforts should target work processes associated with the most frequent and most severe injuries. Future studies should establish time estimates for work processes in order to determine risk estimates. Efforts to improve non-fatal injury reporting, especially on smaller commercial fishing vessels, should be undertaken.

Utility of a Work Process Classification System for characterizing non-fatal injuries in the Alaskan commercial fishing industry.

PubMed

Syron, Laura N; Lucas, Devin L; Bovbjerg, Viktor E; Bethel, Jeffrey W; Kincl, Laurel D

2016-01-01

The US commercial fishing industry is hazardous, as measured by mortality data. However, research on non-fatal injuries is limited. Non-fatal injuries constitute the majority of occupational injuries and can result in workers' lowered productivity and wages, lost quality of life, and disability. In the United States, a Work Process Classification System (WPCS) has previously been applied in Alaskan freezer-trawl and freezer-longline fleets to identify causes of injuries and specific hazards, but not to other fishing fleets. This descriptive epidemiologic study aimed to explore the application and modification of the WPCS in multiple Alaskan fleets, characterize non-fatal occupational injuries in these fleets, and identify work processes that could be targeted for further investigation and future injury prevention efforts. Traumatic, non-fatal injuries on-board Alaskan commercial fishing vessels were identified through United States Coast Guard investigative reports. Characteristics of injuries, as well as worker characteristics, were analysed. Injuries were coded using the WPCS. We successfully utilized the WPCS to code non-fatal injury cases (n = 136). The most frequent main work processes associated with non-fatal injuries included: on-board trawlers, handling frozen fish and processing the catch; on-board vessels using pot/trap gear, handling the gear and shooting/setting the gear; on-board longliners, traffic on board and hauling the gear; and on-board processor vessels, processing the catch, other work with the catch, and handling frozen fish. The study confirmed that a WPCS can be applied to multiple Alaskan fleets to identify hazardous tasks. Hazards were unique for each vessel gear type. Future injury prevention efforts should target work processes associated with the most frequent and most severe injuries. Future studies should establish time estimates for work processes in order to determine risk estimates. Efforts to improve non-fatal injury reporting, especially on smaller commercial fishing vessels, should be undertaken.

Extra-rectal lymphogranuloma venereum in France: a clinical and molecular study.

PubMed

Desclaux, Arnaud; Touati, Arabella; Neau, Didier; Laurier-Nadalié, Cécile; Bébéar, Cécile; de Barbeyrac, Bertille; Cazanave, Charles

2018-02-01

To describe a series of extrarectal lymphogranuloma venereum (LGV) cases diagnosed in France. Consecutive LGV cases confirmed at the French Reference Centre for chlamydiae with an extrarectal sample from January 2010 to December 2015 were included. The first part of the study consisted of a retrospective case note review and analysis. In a second part, the complete omp A gene sequence of our samples was determined. There were 56 cases overall: 50 cases of genital LGV and six cases of pharyngeal LGV. Subjects were all men, median age 39 years, 27/53 were HIV-positive, 47/51 reported having sex with other men, 43/49 reported multiple sexual partners (a mean 25 in the last 6 months). Median time from symptom onset to diagnosis was 21 days. Subjects most commonly presented with inguinal adenopathy alone (19 of 50 genital cases) and adenopathy with genital ulcer (17 of 50). Three pharyngeal cases were symptomatic. Fever was reported in 11 cases. Inguinal abscess was reported in 22 of 42 cases presenting with lymphadenopathy. Co-infections were frequent: eight cases of syphilis, four non-LGV Chlamydia trachomatis infections, one case of gonorrhoea. Cure was always achieved with doxycycline therapy but prolonged treatment was necessary in eight cases with inguinal abscess. Genotyping according to omp A sequencing showed the co-circulation of genovars L2 (16 of 42 strains successfully typed) and L2b (24 of 42). There was no association between HIV status and disease severity or genovar distribution. In the span of 6 years, 56 extrarectal LGV cases were confirmed through genotyping in France. Extrarectal LGV seemed to share a common epidemiological background with rectal disease in terms of affected population and genovar distribution. HIV prevalence was lower than expected. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Listeria monocytogenes infection from foods prepared in a commercial establishment: a case-control study of potential sources of sporadic illness in the United States.

PubMed

Varma, Jay K; Samuel, Michael C; Marcus, Ruthanne; Hoekstra, Robert M; Medus, Carlota; Segler, Suzanne; Anderson, Bridget J; Jones, Timothy F; Shiferaw, Beletshachew; Haubert, Nicole; Megginson, Melanie; McCarthy, Patrick V; Graves, Lewis; Gilder, Thomas Van; Angulo, Frederick J

2007-02-15

Listeria monocytogenes has been estimated to cause >2500 illnesses and 500 deaths annually in the United States. Efforts to reduce foodborne listeriosis have focused on foods frequently implicated in outbreaks. Potential sources for L. monocytogenes infection not associated with outbreaks remain poorly understood. The Foodborne Diseases Active Surveillance Network conducts surveillance for culture-confirmed listeriosis at clinical laboratories in 9 states. After excluding outbreak-associated cases, we attempted to enroll eligible case patients with L. monocytogenes infection in a case-control study from 2000 through 2003. Control subjects were recruited through health care providers and were matched to case patients by state, age, and immunosuppression status. Data were collected about exposures occurring in the 4 weeks before specimen collection from the case patients. Of the 249 case patients with L. monocytogenes infection, only 12 (5%) had cases that were associated with outbreaks; 6 other patients were ineligible for other reasons. Of 231 eligible case patients, 169 (73%) were enrolled in the study. We classified 28 case patients as having pregnancy-associated cases. We enrolled 376 control subjects. In multivariable analysis, L. monocytogenes infection was associated with eating melons at a commercial establishment (odds ratio, 2.6; 95% confidence interval, 1.4-5.0) and eating hummus prepared in a commercial establishment (odds ratio, 5.7; 95% confidence interval, 1.7-19.1). Most cases of L. monocytogenes infection were not associated with outbreaks. Reducing the burden of foodborne listeriosis may require interventions directed at retail environments and at foods, such as melons and hummus, that are not commonly recognized as high risk. Because of the severity of listeriosis, pregnant women and other persons at risk may wish to avoid eating these newly implicated foods.

Economic Analysis and Business Case for Motor Carrier Industry Support of CVISN (Commercial Vehicle Information Systems and Networks)

DOT National Transportation Integrated Search

2007-10-02

The objective was to evaluate economic justifications for motor carriers to participate in CVISN deployment. CVISN (Commercial Vehicle Information Systems and Networks) includes: interstate credentials administration (registration and permitting), el...

Exogenous thyrotoxicosis in dogs attributable to consumption of all-meat commercial dog food or treats containing excessive thyroid hormone: 14 cases (2008-2013).

PubMed

Broome, Michael R; Peterson, Mark E; Kemppainen, Robert J; Parker, Valerie J; Richter, Keith P

2015-01-01

To describe findings in dogs with exogenous thyrotoxicosis attributable to consumption of commercially available dog foods or treats containing high concentrations of thyroid hormone. Retrospective and prospective case series. 14 dogs. Medical records were retrospectively searched to identify dogs with exogenous thyrotoxicosis attributable to dietary intake. One case was found, and subsequent cases were identified prospectively. Serum thyroid hormone concentrations were evaluated before and after feeding meat-based products suspected to contain excessive thyroid hormone was discontinued. Scintigraphy was performed to evaluate thyroid tissue in 13 of 14 dogs before and 1 of 13 dogs after discontinuation of suspect foods or treats. Seven samples of 5 commercially available products fed to 6 affected dogs were analyzed for thyroxine concentration; results were subjectively compared with findings for 10 other commercial foods and 6 beef muscle or liver samples. Total serum thyroxine concentrations were high (median, 8.8 μg/dL; range, 4.65 to 17.4 μg/dL) in all dogs at initial evaluation; scintigraphy revealed subjectively decreased thyroid gland radionuclide in 13 of 13 dogs examined. At ≥ 4 weeks after feeding of suspect food or treats was discontinued, total thyroxine concentrations were within the reference range for all dogs and signs associated with thyrotoxicosis, if present, had resolved. Analysis of tested food or treat samples revealed a median thyroxine concentration for suspect products of 1.52 μg of thyroxine/g, whereas that of unrelated commercial foods was 0.38 μg of thyroxine/g. Results indicated that thyrotoxicosis can occur secondary to consumption of meat-based products presumably contaminated by thyroid tissue, and can be reversed by identification and elimination of suspect products from the diet.

Rethinking antibiotic research and development: World War II and the penicillin collaborative.

PubMed

Quinn, Roswell

2013-03-01

Policy leaders and public health experts may be overlooking effective ways to stimulate innovative antibiotic research and development. I analyzed archival resources concerning the US government's efforts to produce penicillin during World War II, which demonstrate how much science policy can differ from present approaches. By contrast to current attempts to invigorate commercial participation in antibiotic development, the effort to develop the first commercially produced antibiotic did not rely on economic enticements or the further privatization of scientific resources. Rather, this extremely successful scientific and, ultimately, commercial endeavor was rooted in government stewardship, intraindustry cooperation, and the open exchange of scientific information. For policymakers facing the problem of stimulating antibiotic research and development, the origins of the antibiotic era offer a template for effective policy solutions that concentrate primarily on scientific rather than commercial goals.

On the way to commercializing plant cell culture platform for biopharmaceuticals: present status and prospect

PubMed Central

Xu, Jianfeng; Zhang, Ningning

2014-01-01

Plant cell culture is emerging as an alternative bioproduction system for recombinant pharmaceuticals. Growing plant cells in vitro under controlled environmental conditions allows for precise control over cell growth and protein production, batch-to-batch product consistency and a production process aligned with current good manufacturing practices. With the recent US FDA approval and commercialization of the world’s first plant cell-based recombinant pharmaceutical for human use, β-glucocerebrosidase for treatment of Gaucher’s disease, a new era has come in which plant cell culture shows high potential to displace some established platform technologies in niche markets. This review updates the progress in plant cell culture processing technology, highlights recent commercial successes and discusses the challenges that must be overcome to make this platform commercially viable. PMID:25621170

The translation of product concept to bone products: a partnership of therapeutic effectiveness and commercialization.

PubMed

Ratcliffe, Anthony

2011-12-01

The fields of tissue engineering and regenerative medicine have the capacity to substantially impact clinical care through the introduction of new products that can address unmet clinical needs, or significantly improve on present therapies. These products will be developed through the demonstration of therapeutic effectiveness, adequate safety, and meeting regulatory requirements. The technology used in the product will dictate the product development and manufacturing costs; the regulatory pathway; and the time taken to complete clinical trials, gain regulatory approval, and become commercialized. A comparison of the required investment of time and funds, with the potential revenue generated, allows for a determination of the likely commercialization opportunity. Ultimately, the long-term success of a product will be dependent on its clinical effectiveness and commercial viability. © Mary Ann Liebert, Inc.

Rethinking Antibiotic Research and Development: World War II and the Penicillin Collaborative

PubMed Central

2013-01-01

Policy leaders and public health experts may be overlooking effective ways to stimulate innovative antibiotic research and development. I analyzed archival resources concerning the US government’s efforts to produce penicillin during World War II, which demonstrate how much science policy can differ from present approaches. By contrast to current attempts to invigorate commercial participation in antibiotic development, the effort to develop the first commercially produced antibiotic did not rely on economic enticements or the further privatization of scientific resources. Rather, this extremely successful scientific and, ultimately, commercial endeavor was rooted in government stewardship, intraindustry cooperation, and the open exchange of scientific information. For policymakers facing the problem of stimulating antibiotic research and development, the origins of the antibiotic era offer a template for effective policy solutions that concentrate primarily on scientific rather than commercial goals. PMID:22698031

Feasibility of in utero telemetric fetal ECG monitoring in a lamb model.

PubMed

Hermans, Bart; Lewi, Liesbeth; Jani, Jacques; De Buck, Frederik; Deprest, Jan; Puers, Robert

2008-01-01

If fetal ECG (fECG) devices could be miniaturized sufficiently, one could consider their implantation at the time of fetal surgery to allow permanent monitoring of the fetus and timely intervention in the viable period. We set up an experiment to evaluate the feasibility of in utero direct fECG monitoring and telemetric transmission using a small implantable device in a lamb model. A 2-lead miniature ECG sensor (volume 1.9 cm(3); weight 3.9 g) was subcutaneously implanted in 2 fetal lambs at 122 days gestation (range 119-125; term 145 days). The ECG sensor can continuously register and transmit fECG. The signal is captured by an external receiving antenna taped to the maternal abdominal wall. We developed dedicated software running on a commercial laptop for on-line analysis of the transmitted fECG signal. This was a noninterventional study, i.e. daily readings of the fECG signal were done without clinical consequences to the observations. fECG could be successfully registered, transmitted by telemetry and analyzed from the moment of implantation till term birth in one case (24 days). In the second case, unexplained in utero fetal death occurred 12 days after implantation. In this subject, agonal fECG changes were recorded. An implanted miniature (<2 ml) ECG sensor can be used to retrieve, process and transmit continuously a qualitative fECG signal in third-trimester fetal lambs. The telemetric signal could be picked up by an external antenna located within a 20-cm range. In this experiment, this was achieved through taping the external receiver to the maternal abdomen. Any acquired signal could be transmitted to a commercially available laptop that could perform on-line analysis of the signal. (c) 2008 S. Karger AG, Basel.

Evaluations of UltraiQ software for objective ultrasound image quality assessment using images from a commercial scanner.

PubMed

Long, Zaiyang; Tradup, Donald J; Stekel, Scott F; Gorny, Krzysztof R; Hangiandreou, Nicholas J

2018-03-01

We evaluated a commercially available software package that uses B-mode images to semi-automatically measure quantitative metrics of ultrasound image quality, such as contrast response, depth of penetration (DOP), and spatial resolution (lateral, axial, and elevational). Since measurement of elevational resolution is not a part of the software package, we achieved it by acquiring phantom images with transducers tilted at 45 degrees relative to the phantom. Each measurement was assessed in terms of measurement stability, sensitivity, repeatability, and semi-automated measurement success rate. All assessments were performed on a GE Logiq E9 ultrasound system with linear (9L or 11L), curved (C1-5), and sector (S1-5) transducers, using a CIRS model 040GSE phantom. In stability tests, the measurements of contrast, DOP, and spatial resolution remained within a ±10% variation threshold in 90%, 100%, and 69% of cases, respectively. In sensitivity tests, contrast, DOP, and spatial resolution measurements followed the expected behavior in 100%, 100%, and 72% of cases, respectively. In repeatability testing, intra- and inter-individual coefficients of variations were equal to or less than 3.2%, 1.3%, and 4.4% for contrast, DOP, and spatial resolution (lateral and axial), respectively. The coefficients of variation corresponding to the elevational resolution test were all within 9.5%. Overall, in our assessment, the evaluated package performed well for objective and quantitative assessment of the above-mentioned image qualities under well-controlled acquisition conditions. We are finding it to be useful for various clinical ultrasound applications including performance comparison between scanners from different vendors. © 2018 The Authors. Journal of Applied Clinical Medical Physics published by Wiley Periodicals, Inc. on behalf of American Association of Physicists in Medicine.

DEFINING THE CHEMICAL SPACE OF PUBLIC GENOMIC DATA.

EPA Science Inventory

The pharmaceutical industry has demonstrated success in integrating of chemogenomic knowledge into predictive toxicological models, due in part to industry's access to large amounts of proprietary and commercial reference genomic data sets.

Applications of aerospace technology

NASA Technical Reports Server (NTRS)

Rouse, Doris J.

1984-01-01

The objective of the Research Triangle Institute Technology Transfer Team is to assist NASA in achieving widespread utilization of aerospace technology in terrestrial applications. Widespread utilization implies that the application of NASA technology is to benefit a significant sector of the economy and population of the Nation. This objective is best attained by stimulating the introduction of new or improved commercially available devices incorporating aerospace technology. A methodology is presented for the team's activities as an active transfer agent linking NASA Field Centers, industry associations, user groups, and the medical community. This methodology is designed to: (1) identify priority technology requirements in industry and medicine, (2) identify applicable NASA technology that represents an opportunity for a successful solution and commercial product, (3) obtain the early participation of industry in the transfer process, and (4) successfully develop a new product based on NASA technology.

If it Works, Will it Matter?

DOE Office of Scientific and Technical Information (OSTI.GOV)

Martin, Cheryl; Gerst, Kacy; Gould, Josh

Technical success is one thing, but commercial success is another. ARPA-E’s unique Technology-to-Market program was designed to help our awardees move their research out of the lab and into the market, accelerating the adoption of potentially game-changing technologies. The Technology-to-Market team is dedicated to the common goal of answering the fundamental question: if it works, will it matter? Featuring remarks from Cheryl Martin, ARPA-E’s Deputy Director for Commercialization, as well as interviews with three members of the Technology-to-Market team, this video demonstrates ARPA-E’s commitment to both the development and deployment of transformational energy technologies. The video also incorporates footage shotmore » on site with several ARPA-E awardees, much of which will be highlighted in other videos shown throughout the 2015 ARPA-E Energy Innovation Summit.« less

Propesticides and their use as agrochemicals.

PubMed

Jeschke, Peter

2016-02-01

The synthesis of propesticides is an important concept in design of modern agrochemicals with optimal efficacy, environmental safety, user friendliness and economic variability. Based on increasing knowledge of the biochemistry and genetics of major pest insects, weeds and agricultural pathogens, the search for selectivity has become an ever more important part of pesticide development and can be achieved by appropriate structural modifications of the active ingredient. Propesticides affect the absorption, distribution, metabolism and excretion parameters, which can lead to biological superiority of these modified active ingredients over their non-derivatised analogues. Various selected commercial propesticides testify to the successful utilisation of this concept in the design of agrochemicals. This review describes comprehensively the successful utilisation of propesticides and their role in syntheses of modern agrochemicals, exemplified by selected commercial products coming from different agrochemical areas. © 2015 Society of Chemical Industry.

If it Works, Will it Matter?

ScienceCinema

Martin, Cheryl; Gerst, Kacy; Gould, Josh; Babinec, Sue

2018-05-11

Technical success is one thing, but commercial success is another. ARPA-E’s unique Technology-to-Market program was designed to help our awardees move their research out of the lab and into the market, accelerating the adoption of potentially game-changing technologies. The Technology-to-Market team is dedicated to the common goal of answering the fundamental question: if it works, will it matter? Featuring remarks from Cheryl Martin, ARPA-E’s Deputy Director for Commercialization, as well as interviews with three members of the Technology-to-Market team, this video demonstrates ARPA-E’s commitment to both the development and deployment of transformational energy technologies. The video also incorporates footage shot on site with several ARPA-E awardees, much of which will be highlighted in other videos shown throughout the 2015 ARPA-E Energy Innovation Summit.

The biotechnology innovation machine: a source of intelligent biopharmaceuticals for the pharma industry--mapping biotechnology's success.

PubMed

Evens, R P; Kaitin, K I

2014-05-01

The marriage of biotechnology and the pharmaceutical industry (pharma) is predicated on an evolution in technology and product innovation. It has come as a result of advances in both the science and the business practices of the biotechnology sector in the past 30 years. Biotechnology products can be thought of as "intelligent pharmaceuticals," in that they often provide novel mechanisms of action, new approaches to disease control, higher clinical success rates, improved patient care, extended patent protection, and a significant likelihood of reimbursement. Although the first biotechnology product, insulin, was approved just 32 years ago in 1982, today there are more than 200 biotechnology products commercially available. Research has expanded to include more than 900 biotechnology products in clinical trials. Pharma is substantially engaged in both the clinical development of these products and their commercialization.

Influence of Nest Box Color and Release Sites on Osmia lignaria (Hymenoptera: Megachilidae) Reproductive Success in a Commercial Almond Orchard.

PubMed

Artz, Derek R; Allan, Matthew J; Wardell, Gordon I; Pitts-Singer, Theresa L

2014-12-01

Intensively managed, commercial orchards offer resources for managed solitary bees within agricultural landscapes and provide a means to study bee dispersal patterns, spatial movement, nest establishment, and reproduction. In 2012, we studied the impact of 1) the color of nest boxes covaried with four nest box density treatments and 2) the number of bee release sites covaried with two nest box density treatments on the reproductive success of Osmia lignaria Say in a California almond orchard pollinated by a mixture of O. lignaria and Apis mellifera L. Nest box color influenced the number of nests, total cells, and cells with male and female brood. More nests and cells were produced in light blue nest boxes than in orange or yellow nest boxes. The covariate nest box density also had a significant effect on brood production. The number of release sites did not affect O. lignaria nesting and reproduction, but the number of cavities in nest boxes influenced reproduction. Overall, the color of nest boxes and their distribution, but not the number of release sites, can greatly affect O. lignaria nest establishment and reproductive success in a commercial almond orchard. The ability to locate nesting sites in a homogenous, large orchard landscape may also be facilitated by the higher frequency of nest boxes with low numbers of cavities, and by the ability to detect certain nest box colors that best contrast with the blooming trees. © 2014 Entomological Society of America.

Profession, market and class: nurse migration and the remaking of division and disadvantage.

PubMed

Smith, Pam; Mackintosh, Maureen

2007-12-01

This article aims to analyse the part played by successive waves of nurse migration in changing patterns of division and disadvantage within nursing. We argue that migration has in part acted to reinforce disadvantage based on class and gender, race and ethnicity and identify the influence of changes in nursing structure and commercialization of care in these processes. BACKGROUND, DESIGN AND METHODS: The historical analysis of division within nursing and the impact of migration are based on secondary sources (literature review) and primary research undertaken by ourselves and colleagues. The paper develops a concept of 'remaking' disadvantage drawing on analysis in social history of the interplay between agency and economic position in the 'making' of class. It uses the extended case method to focus on the residential care sector, showing how global and national influences operate at the frontline of service delivery. We show how social class and gender, race and ethnicity have interacted and are reflected in the division of labour within nursing. We demonstrate how the employment conditions of nurse migrants have reinforced patterns of disadvantage. The case study of the residential care home sector deepens our analysis of intersecting sources of professional disadvantage including aspects of commercialization, in a sector where they have severe effects for vulnerable staff and patients. In the UK, migrant professional nurses have repeatedly acted both as a highly valued labour force on whom patients and clients rely and as involuntary contributors to remaking disadvantage. This situation is sustained by the current international labour market and rising commercialization which facilitate nurse migration and the segmentation of care work based on a 'pecking order' of specialties that reinforce existing divisions of social class, gender and race within nursing. Migrant nurses play a key role in the delivery of 'frontline' care to patients. The role many currently play reinforces disadvantage within nursing in ways that are problematic for the profession, patients and clients. The recognition and valuing of their skills is critical to the promotion of their own morale which in turn has an impact on their relationship with colleagues and the delivery of patient and client care.

Soft Robotics Commercialization: Jamming Grippers from Research to Product

PubMed Central

Cheng, Nadia; Fakhouri, Sami; Culley, Bill

2016-01-01

Abstract Recent work in the growing field of soft robotics has demonstrated a number of very promising technologies. However, to make a significant impact in real-world applications, these new technologies must first transition out of the laboratory through successful commercialization. Commercialization is perhaps the most critical future milestone facing the field of soft robotics today, and this process will reveal whether the apparent impact we now perceive has been appropriately estimated. Since 2012, Empire Robotics has been one of the first companies to attempt to reach this milestone through our efforts to commercialize jamming-based robotic gripper technology in a product called VERSABALL®. However, in spring 2016 we are closing our doors, having not been able to develop a sustainable business around this technology. This article presents some of the key takeaways from the technical side of the commercialization process and lessons learned that may be valuable to others. We hope that sharing this information will provide a frame of reference for technology commercialization that can help others motivate research directions and maximize research impact. PMID:28078197

Three near term commercial markets in space and their potential role in space exploration

NASA Astrophysics Data System (ADS)

Gavert, Raymond B.

2001-02-01

Independent market studies related to Low Earth Orbit (LEO) commercialization have identified three near term markets that have return-on-investment potential. These markets are: (1) Entertainment (2) Education (3) Advertising/sponsorship. Commercial activity is presently underway focusing on these areas. A private company is working with the Russians on a commercial module attached to the ISS that will involve entertainment and probably the other two activities as well. A separate corporation has been established to commercialize the Russian Mir Space Station with entertainment and promotional advertising as important revenue sources. A new startup company has signed an agreement with NASA for commercial media activity on the International Space Station (ISS). Profit making education programs are being developed by a private firm to allow students to play the role of an astronaut and work closely with space scientists and astronauts. It is expected that the success of these efforts on the ISS program will extend to exploration missions beyond LEO. The objective of this paper is to extrapolate some of the LEO commercialization experiences to see what might be expected in space exploration missions to Mars, the Moon and beyond. .

Space-Derived Imagery and a Commercial Remote Sensing Industry: Impossible Dream or Inevitable Reality?

NASA Astrophysics Data System (ADS)

Murray, Felsher

Landsat-1 was launched in 1972 as a research satellite. Many of us viewed this satellite as a precursor to remote sensing "commercialization." Indeed since that time, the birth, growth and maturation of a remote sensing "industry" has been an ongoing objective for much of the U.S. private sector engaged in space and ground-segment activities related to the acquisition, analysis, and dissemination of imagery. In September 1999 a U.S. commercial entity, Space Imaging, Inc. launched its 1-meter pan/4-meter multispectral IKONOS sensor. DigitalGlobe, Inc. (nee EarthWatch, Inc.) matched this feat in October 2001. Thus, a full 30 years later, we are finally on the brink of building a true remote sensing information industry based on the global availability of competitively-priced space- derived imagery of the Earth. The upcoming availability of similar imagery from non-U.S. sources as ImageSat and U.S. sources as ORBIMAGE will only strengthen that reality. However, a remote sensing industry can only grow by allowing these entities (in times of peace) unencumbered access to a world market. And that market continues to expand -- up 11% in 2001, with gross revenues of U.S. commercial remote sensing firms alone reaching 2.44 billion, according to a joint NASA/ASPRS industry survey. However, the 30-year gap between the research-labeled Landsat-1 and our current commercial successes was not technology-driven. That lacuna was purely political -- driven by valid concerns related to national security. Although the world's governments have cooperated thoroughly and completely in areas related to satellite telecommunications, cooperation in space-derived image information is still today done cautiously and on a case-by-case basis -- and then only for science- based undertakings. It is still a fact that, except for the United States, all other Earth-imaging satellites/sensors flying today are owned, operated, and their products disseminated, by national governments -- and not private sector entities. Will the template now fashioned by the U.S. -- that of licensing private industry to build, fly, and operate remote sensing satellites as well as to distribute their imagery worldwide -- be replicated by other nations? Eventually, yes. Availability of the World Wide Web is an international communications reality. Availability of world wide imaging will be just as real. And much of that imagery will be marketed, sold, and distributed via that same global Internet. I feel that as an expected outcome of our technological age, we can ensure not only our own national security but international security as well, by assuring worldwide accessibility to worldwide space- derived image information. This requires -- in fact demands -- the presence of a viable international remote sensing industry. It is not impossible; It is inevitable.

Quantifying factors for the success of stratified medicine.

PubMed

Trusheim, Mark R; Burgess, Breon; Hu, Sean Xinghua; Long, Theresa; Averbuch, Steven D; Flynn, Aiden A; Lieftucht, Alfons; Mazumder, Abhijit; Milloy, Judy; Shaw, Peter M; Swank, David; Wang, Jian; Berndt, Ernst R; Goodsaid, Federico; Palmer, Michael C

2011-10-31

Co-developing a drug with a diagnostic to create a stratified medicine - a therapy that is targeted to a specific patient population on the basis of a clinical characteristic such as a biomarker that predicts treatment response - presents challenges for product developers, regulators, payers and physicians. With the aim of developing a shared framework and tools for addressing these challenges, here we present an analysis using data from case studies in oncology and Alzheimer's disease, coupled with integrated computational modelling of clinical outcomes and developer economic value, to quantify the effects of decisions related to key issues such as the design of clinical trials. This illustrates how such analyses can aid the coordination of diagnostic and drug development, and the selection of optimal development and commercialization strategies. It also illustrates the impact of the interplay of these factors on the economic feasibility of stratified medicine, which has important implications for public policy makers.

Advanced Space Transportation Program (ASTP)

NASA Image and Video Library

2002-10-01

NASA's Marshall Space Flight Center in Huntsville, Alabama, manages the Space Launch Initiative (SLI), NASA's priority developmental program focused on empowering America's leadership in space. SLI includes commercial, higher education, and defense partnerships and contracts to offer widespread participation in both the risk and success of developing our nation's next-generation reusable launch vehicle. This photo depicts an artist's concept of a future second-generation launch vehicle. For the SLI, architecture definition includes all components of the next-generation reusable launch system: Earth-to-orbit vehicles (the Space Shuttle is the first generation earth-to-orbit vehicle), crew transfer vehicles, transfer stages, ground processing systems, flight operations systems, and development of business case strategies. Three contractor teams have each been funded to develop potential second- generation reusable launch system architectures: The Boeing Company of Seal Beach, California; Lockheed Martin Corporation of Denver, Colorado along with a team including Northrop Grumman of El Segundo, California; and Orbital Sciences Corporation of Dulles, Virginia.

Advanced Space Transportation Program (ASTP)

NASA Image and Video Library

2002-10-01

NASA's Marshall Space Flight Center in Huntsville, Alabama, manages the Space Launch Initiative (SLI), NASA's priority developmental program focused on empowering America's leadership in space. SLI includes commercial, higher education and defense partnerships and contracts to offer widespread participation in both the risk and success of developing our nation's next-generation reusable launch vehicle. This photo depicts an artist's concept of a future second-generation launch vehicle during separation of stages. For SLI, architecture definition includes all components of the next-generation reusable launch system: Earth-to-orbit vehicles (the Space Shuttle is the first-generation earth-to-orbit vehicle), crew transfer vehicles, transfer stages, ground processing systems, flight operations systems, and development of business case strategies. Three contractor teams have each been funded to develop potential second generation reusable launch system architectures: The Boeing Company of Seal Beach, California; Lockheed Martin Corporation of Denver, Colorado; a team including Northrop Grumman of El Segundo, California; and Orbital Sciences Corporation of Dulles, Virginia.

The political and social barriers for contraception in pest birds: a case study of Ovocontrol (nicarbazin).

PubMed

MacDonald, Alexander; Wolf, Erick

2013-12-01

In a joint program, Innolytics and the U.S. Department of Agriculture/Animal and Plant Health Inspection Service National Wildlife Research Center collaborated in the development of nicarbazin as an avian contraceptive, initially for resident Canada geese and subsequently for feral pigeons. Unfortunately, the introduction of the original goose product in 2005 was a commercial failure. Political and social barriers effectively thwarted attempts to establish the new technology with any meaningful market success. Although the market adoption of the pigeon contraceptive has been less difficult, the product still encounters significant social and political obstacles and opposition. Given the focus on instant results and gratification, the introduction of contraceptive technology for birds has been challenging and broad market acceptance remains elusive. Nevertheless, especially for short-lived and rapidly reproducing species, customers continue to replace outdated or ineffective techniques with the safer and more effective contraceptive tool.

The social comfort of wearable technology and gestural interaction.

PubMed

Dunne, Lucy E; Profita, Halley; Zeagler, Clint; Clawson, James; Gilliland, Scott; Do, Ellen Yi-Luen; Budd, Jim

2014-01-01

The "wearability" of wearable technology addresses the factors that affect the degree of comfort the wearer experiences while wearing a device, including physical, psychological, and social aspects. While the physical and psychological aspects of wearing technology have been investigated since early in the development of the field of wearable computing, the social aspects of wearability have been less fully-explored. As wearable technology becomes increasingly common on the commercial market, social wearability is becoming an ever-more-important variable contributing to the success or failure of new products. Here we present an analysis of social aspects of wearability within the context of the greater understanding of wearability in wearable technology, and focus on selected theoretical frameworks for understanding how wearable products are perceived and evaluated in a social context. Qualitative results from a study of social acceptability of on-body interactions are presented as a case study of social wearability.

Thin blue lines: product placement and the drama of pregnancy testing in British cinema and television.

PubMed

Olszynko-Gryn, Jesse

2017-09-01

This article uses the case of pregnancy testing in Britain to investigate the process whereby new and often controversial reproductive technologies are made visible and normalized in mainstream entertainment media. It shows how in the 1980s and 1990s the then nascent product placement industry was instrumental in embedding pregnancy testing in British cinema and television's dramatic productions. In this period, the pregnancy-test close-up became a conventional trope and the thin blue lines associated with Unilever's Clearblue rose to prominence in mainstream consumer culture. This article investigates the aestheticization of pregnancy testing and shows how increasingly visible public concerns about 'schoolgirl mums', abortion and the biological clock, dramatized on the big and small screen, propelled the commercial rise of Clearblue. It argues that the Clearblue close-up ambiguously concealed as much as it revealed; abstraction, ambiguity and flexibility were its keys to success.

Design of experimental setup for supercritical CO2 jet under high ambient pressure conditions

NASA Astrophysics Data System (ADS)

Shi, Huaizhong; Li, Gensheng; He, Zhenguo; Wang, Haizhu; Zhang, Shikun

2016-12-01

With the commercial extraction of hydrocarbons in shale and tight reservoirs, efficient methods are needed to accelerate developing process. Supercritical CO2 (SC-CO2) jet has been considered as a potential way due to its unique fluid properties. In this article, a new setup is designed for laboratory experiment to research the SC-CO2 jet's characteristics in different jet temperatures, pressures, standoff distances, ambient pressures, etc. The setup is composed of five modules, including SC-CO2 generation system, pure SC-CO2 jet system, abrasive SC-CO2 jet system, CO2 recovery system, and data acquisition system. Now, a series of rock perforating (or case cutting) experiments have been successfully conducted using the setup about pure and abrasive SC-CO2 jet, and the results have proven the great perforating efficiency of SC-CO2 jet and the applications of this setup.

Use of a Tourniquet by LIFE STAR Air Medical Crew: A Case Report.

PubMed

Jacobs, Lenworth M; Burns, Karyl J; Priest, Heather Standish; Muskett, William

2015-10-01

For many years tourniquets were perceived as dangerous due to the belief that they led to loss of limb because of ischemia. Their use in civilian and military environments was discouraged. Emergency medical responders were not taught about tourniquets and commercial tourniquets were not available. However, research by the United States military during the wars in Iraq and Afghanistan has demonstrated that tourniquets are safe life-saving devices. As a consequence, they have been widely deployed in combat situations and there are now calls for the use of tourniquets in the civilian prehospital setting. This article presents a report of the successful application of a tourniquet by the LIFE STAR crew to control bleeding that local emergency medical services (EMS) personnel could not control with direct pressure. Tourniquets should be readily available in public places and carried by all EMS.

Design of experimental setup for supercritical CO2 jet under high ambient pressure conditions.

PubMed

Shi, Huaizhong; Li, Gensheng; He, Zhenguo; Wang, Haizhu; Zhang, Shikun

2016-12-01

With the commercial extraction of hydrocarbons in shale and tight reservoirs, efficient methods are needed to accelerate developing process. Supercritical CO 2 (SC-CO 2 ) jet has been considered as a potential way due to its unique fluid properties. In this article, a new setup is designed for laboratory experiment to research the SC-CO 2 jet's characteristics in different jet temperatures, pressures, standoff distances, ambient pressures, etc. The setup is composed of five modules, including SC-CO 2 generation system, pure SC-CO 2 jet system, abrasive SC-CO 2 jet system, CO 2 recovery system, and data acquisition system. Now, a series of rock perforating (or case cutting) experiments have been successfully conducted using the setup about pure and abrasive SC-CO 2 jet, and the results have proven the great perforating efficiency of SC-CO 2 jet and the applications of this setup.

A qualitative examination of perceptions of physical activity guidelines and preferences for format.

PubMed

Berry, Tanya R; Witcher, Chad; Holt, Nicholas L; Plotnikoff, Ronald C

2010-11-01

A descriptive exploratory study was conducted to gain an understanding of public perceptions of physical activity guidelines and to discover what formats appeal to participants. Canada's Physical Activity Guide (CPAG) was used as an example of such guidelines. Data were collected from 22 participants in five focus groups (composed of female undergraduate students, female office workers, male office workers, participants in a Type II diabetes rehabilitation program, and participants in a cardiovascular rehabilitation program). Cross-case qualitative analyses were conducted. Six themes emerged under the general categories of familiarity and preferences for PA promotional materials. In terms of familiarity, participants lacked awareness of CPAG and criticized its format. In terms of preferences, participants encouraged the use of stylistically similar messaging to those used by commercial advertisers, wanted personal stories, Internet-based media, and the use of celebrities' success stories. There was little awareness of CPAG and the current format was unappealing.

Microbial synthesis gas utilization and ways to resolve kinetic and mass-transfer limitations.

PubMed

Yasin, Muhammad; Jeong, Yeseul; Park, Shinyoung; Jeong, Jiyeong; Lee, Eun Yeol; Lovitt, Robert W; Kim, Byung Hong; Lee, Jinwon; Chang, In Seop

2015-02-01

Microbial conversion of syngas to energy-dense biofuels and valuable chemicals is a potential technology for the efficient utilization of fossils (e.g., coal) and renewable resources (e.g., lignocellulosic biomass) in an environmentally friendly manner. However, gas-liquid mass transfer and kinetic limitations are still major constraints that limit the widespread adoption and successful commercialization of the technology. This review paper provides rationales for syngas bioconversion and summarizes the reaction limited conditions along with the possible strategies to overcome these challenges. Mass transfer and economic performances of various reactor configurations are compared, and an ideal case for optimum bioreactor operation is presented. Overall, the challenges with the bioprocessing steps are highlighted, and potential solutions are suggested. Future research directions are provided and a conceptual design for a membrane-based syngas biorefinery is proposed. Copyright © 2014 Elsevier Ltd. All rights reserved.

Formal verification of human-automation interaction

NASA Technical Reports Server (NTRS)

Degani, Asaf; Heymann, Michael

2002-01-01

This paper discusses a formal and rigorous approach to the analysis of operator interaction with machines. It addresses the acute problem of detecting design errors in human-machine interaction and focuses on verifying the correctness of the interaction in complex and automated control systems. The paper describes a systematic methodology for evaluating whether the interface provides the necessary information about the machine to enable the operator to perform a specified task successfully and unambiguously. It also addresses the adequacy of information provided to the user via training material (e.g., user manual) about the machine's behavior. The essentials of the methodology, which can be automated and applied to the verification of large systems, are illustrated by several examples and through a case study of pilot interaction with an autopilot aboard a modern commercial aircraft. The expected application of this methodology is an augmentation and enhancement, by formal verification, of human-automation interfaces.

D Modeling with Photogrammetry by Uavs and Model Quality Verification

NASA Astrophysics Data System (ADS)

Barrile, V.; Bilotta, G.; Nunnari, A.

2017-11-01

This paper deals with a test lead by Geomatics laboratory (DICEAM, Mediterranea University of Reggio Calabria), concerning the application of UAV photogrammetry for survey, monitoring and checking. The study case relies with the surroundings of the Department of Agriculture Sciences. In the last years, such area was interested by landslides and survey activities carried out to take the phenomenon under control. For this purpose, a set of digital images were acquired through a UAV equipped with a digital camera and GPS. Successively, the processing for the production of a 3D georeferenced model was performed by using the commercial software Agisoft PhotoScan. Similarly, the use of a terrestrial laser scanning technique allowed to product dense cloud and 3D models of the same area. To assess the accuracy of the UAV-derived 3D models, a comparison between image and range-based methods was performed.

SLI Artist's Concept

NASA Technical Reports Server (NTRS)

2002-01-01

NASA's Marshall Space Flight Center in Huntsville, Alabama, manages the Space Launch Initiative (SLI), NASA's priority developmental program focused on empowering America's leadership in space. SLI includes commercial, higher education, and defense partnerships and contracts to offer widespread participation in both the risk and success of developing our nation's next-generation reusable launch vehicle. This photo depicts an artist's concept of a future second-generation launch vehicle. For the SLI, architecture definition includes all components of the next-generation reusable launch system: Earth-to-orbit vehicles (the Space Shuttle is the first generation earth-to-orbit vehicle), crew transfer vehicles, transfer stages, ground processing systems, flight operations systems, and development of business case strategies. Three contractor teams have each been funded to develop potential second- generation reusable launch system architectures: The Boeing Company of Seal Beach, California; Lockheed Martin Corporation of Denver, Colorado along with a team including Northrop Grumman of El Segundo, California; and Orbital Sciences Corporation of Dulles, Virginia.

SLI Artist `s Launch Concept

NASA Technical Reports Server (NTRS)

2002-01-01

NASA's Marshall Space Flight Center in Huntsville, Alabama, manages the Space Launch Initiative (SLI), NASA's priority developmental program focused on empowering America's leadership in space. SLI includes commercial, higher education and defense partnerships and contracts to offer widespread participation in both the risk and success of developing our nation's next-generation reusable launch vehicle. This photo depicts an artist's concept of a future second-generation launch vehicle during launch. For SLI, architecture definition includes all components of the next-generation reusable launch system: Earth-to-orbit vehicles (the Space Shuttle is the first generation earth-to-orbit vehicle), crew transfer vehicles, transfer stages, ground processing systems, flight operations systems, and development of business case strategies. Three contractor teams have each been funded to develop potential second generation reusable launch system architectures: The Boeing Company of Seal Beach, California; Lockheed Martin Corporation of Denver, Colorado along with a team including Northrop Grumman of El Segundo, California; and Orbital Sciences Corporation of Dulles, Virginia.

SLI Artist's Concept-Stage Separation

NASA Technical Reports Server (NTRS)

2002-01-01

NASA's Marshall Space Flight Center in Huntsville, Alabama, manages the Space Launch Initiative (SLI), NASA's priority developmental program focused on empowering America's leadership in space. SLI includes commercial, higher education and defense partnerships and contracts to offer widespread participation in both the risk and success of developing our nation's next-generation reusable launch vehicle. This photo depicts an artist's concept of a future second-generation launch vehicle during separation of stages. For SLI, architecture definition includes all components of the next-generation reusable launch system: Earth-to-orbit vehicles (the Space Shuttle is the first-generation earth-to-orbit vehicle), crew transfer vehicles, transfer stages, ground processing systems, flight operations systems, and development of business case strategies. Three contractor teams have each been funded to develop potential second generation reusable launch system architectures: The Boeing Company of Seal Beach, California; Lockheed Martin Corporation of Denver, Colorado; a team including Northrop Grumman of El Segundo, California; and Orbital Sciences Corporation of Dulles, Virginia.

Evaluation of green building rating tools based on existing green building achievement in Indonesia using Life Cycle Assessment Method

NASA Astrophysics Data System (ADS)

Basten, Van; Latief, Yusuf; Berawi, Mohammed Ali; Budiman, Rachmat; Riswanto

2017-03-01

Total completed building construction value in Indonesia increased 116% during 2009 to 2011. That's followed by increasing 11% energy consumption in Indonesia in the last three years with 70% energy met to the electricity needs of commercial building. In addition, a few application of green building concept in Indonesia made the greenhouse gas emissions or CO2 amount increased by 25%. Construction, operation, and maintain of building cost consider relatively high. The evaluation in this research is used to improve the building performance with some of green concept alternatives. The research methodology is conducted by combination of qualitative and quantitative approaches through interview and case study. Assessing the successful of optimization functions in the existing green building is based on the operational and maintenance phase with the Life Cycle Assessment (LCA) Method. The result of optimization that is the largest efficiency and effective of building life cycle.

Algorithms Based on CWT and Classifiers to Control Cardiac Alterations and Stress Using an ECG and a SCR

PubMed Central

Villarejo, María Viqueira; Zapirain, Begoña García; Zorrilla, Amaia Méndez

2013-01-01

This paper presents the results of using a commercial pulsimeter as an electrocardiogram (ECG) for wireless detection of cardiac alterations and stress levels for home control. For these purposes, signal processing techniques (Continuous Wavelet Transform (CWT) and J48) have been used, respectively. The designed algorithm analyses the ECG signal and is able to detect the heart rate (99.42%), arrhythmia (93.48%) and extrasystoles (99.29%). The detection of stress level is complemented with Skin Conductance Response (SCR), whose success is 94.02%. The heart rate variability does not show added value to the stress detection in this case. With this pulsimeter, it is possible to prevent and detect anomalies for a non-intrusive way associated to a telemedicine system. It is also possible to use it during physical activity due to the fact the CWT minimizes the motion artifacts. PMID:23666135

Algorithms based on CWT and classifiers to control cardiac alterations and stress using an ECG and a SCR.

PubMed

Villarejo, María Viqueira; Zapirain, Begoña García; Zorrilla, Amaia Méndez

2013-05-10

This paper presents the results of using a commercial pulsimeter as an electrocardiogram (ECG) for wireless detection of cardiac alterations and stress levels for home control. For these purposes, signal processing techniques (Continuous Wavelet Transform (CWT) and J48) have been used, respectively. The designed algorithm analyses the ECG signal and is able to detect the heart rate (99.42%), arrhythmia (93.48%) and extrasystoles (99.29%). The detection of stress level is complemented with Skin Conductance Response (SCR), whose success is 94.02%. The heart rate variability does not show added value to the stress detection in this case. With this pulsimeter, it is possible to prevent and detect anomalies for a non-intrusive way associated to a telemedicine system. It is also possible to use it during physical activity due to the fact the CWT minimizes the motion artifacts.

The dark side of the immunohistochemical moon: industry.

PubMed

Kalyuzhny, Alexander E

2009-12-01

Modern biological research is dependent on tools developed and provided by commercial suppliers, and antibodies for immunohistochemistry are among the most frequently used of these tools. Not all commercial antibodies perform as expected, however; this problem leads researchers to waste time and money when using antibodies that perform inadequately. Different commercial suppliers offer antibodies of varying degrees of quality and, in some cases, are unable to provide expert technical support for the immunohistochemical use of their antibodies. This article briefly describes the production of commercial antibodies from the manufacturer's perspective and presents some guidelines for choosing appropriate commercial antibodies for immunohistochemistry. Additionally, the article suggests steps to establish mutually beneficial relationships between commercial antibody suppliers and researchers who use them.

Training and capacity building evaluation: Maximizing resources and results with Success Case Method.

PubMed

Medina, L; Acosta-Pérez, E; Velez, C; Martínez, G; Rivera, M; Sardiñas, L; Pattatucci, A

2015-10-01

This article describes the use of Success Case Method (Brinkerhoff, 2003) to evaluate health promotion and public health training programs. The goal of the Office Community Research and Engagement (OCRE) of the Puerto Rico Clinical and Translational Research Consortium (PRCTRC) is to establish a stable and sustainable translational research capacity. Early efforts toward achieving this goal included sponsoring two independent research training programs. A description of the implementation of the five step Success Case Method is presented. Results reveal that SCM would deem both trainings as highly successful, based upon the overall impact of a low number of success cases. However, a traditional summative evaluation would consider this disappointing. Strengths of SCM are discussed. It was concluded that the Success Case Method is a useful and valuable evaluative method for measuring the success of health promotion and public health training initiatives and provides sufficient information for decision-making processes. Copyright © 2015 Elsevier Ltd. All rights reserved.

Design of large format commercial display holograms

NASA Astrophysics Data System (ADS)

Perry, John F. W.

1989-05-01

Commercial display holography is approaching a critical stage where the ability to compete with other graphic media will dictate its future. Factors involved will be cost, technical quality and, in particular, design. The tenuous commercial success of display holography has relied heavily on its appeal to an audience with little or no previous experience in the medium. Well designed images were scarce, leading many commercial designers to avoid holography. As the public became more accustomed to holograms, the excitement dissipated, leaving a need for strong visual design if the medium is to survive in this marketplace. Drawing on the vast experience of TV, rock music and magazine advertising, competitive techniques such as video walls, mural duratrans, laser light shows and interactive videos attract a professional support structure far greater than does holography. This paper will address design principles developed at Holographics North for large format commercial holography. Examples will be drawn from a number of foreign and domestic corporate trade exhibitions. Recommendations will also be made on how to develop greater awareness of a holographic design.

Future trends in commercial and military systems

NASA Astrophysics Data System (ADS)

Bond, F. E.

Commercial and military satellite communication systems are addressed, with a review of current applications and typical communication characteristics of the space and earth segments. Drivers for the development of future commercial systems include: the pervasion of digital techniques and services, growing orbit and frequency congestion, demand for more entertainment, and the large potential market for commercial 'roof-top' service. For military systems, survivability, improved flexibility, and the need for service to small mobile terminals are the principal factors involved. Technical trends include the use of higher frequency bands, multibeam antennas and a significant increase in the application of onboard processing. Military systems will employ a variety of techniques to counter both physical and electronic threats. The use of redundant transmission paths is a particularly effective approach. Successful implementation requires transmission standards to achieve the required interoperability among the pertinent networks. For both the military and commercial sectors, the trend toward larger numbers of terminals and more complex spacecraft is still persisting.

Greater weight loss among men participating in a commercial weight loss program: a pooled analysis of 2 randomized controlled trials.

PubMed

Barraj, Leila M; Murphy, Mary M; Heshka, Stanley; Katz, David L

2014-02-01

Being overweight and obese are significant health concerns for men and women, yet despite comparable needs for effective weight loss and maintenance strategies, little is known about the success of commercial weight loss programs in men. This study tests the hypothesis that men participating in a commercial weight loss program (Weight Watchers) had significantly greater weight loss than men receiving limited support from health professionals for weight loss (controls). A pooled analysis of weight loss and related physiologic parameter data from 2 randomized clinical trials was conducted. After 12 months, analysis of covariance tests showed that men in the commercial program group (n = 85) lost significantly more weight (P < .01) than men in the control group (n = 84); similar significant differences were observed for body mass index and waist circumference. These results suggest that participation in a commercial weight loss program may be a more effective means to lose weight and maintain weight loss. Published by Elsevier Inc.

Green factory: plants as bioproduction platforms for recombinant proteins.

PubMed

Xu, Jianfeng; Dolan, Maureen C; Medrano, Giuliana; Cramer, Carole L; Weathers, Pamela J

2012-01-01

Molecular farming, long considered a promising strategy to produce valuable recombinant proteins not only for human and veterinary medicine, but also for agriculture and industry, now has some commercially available products. Various plant-based production platforms including whole-plants, aquatic plants, plant cell suspensions, and plant tissues (hairy roots) have been compared in terms of their advantages and limits. Effective recombinant strategies are summarized along with descriptions of scalable culture systems and examples of commercial progress and success. Copyright © 2011 Elsevier Inc. All rights reserved.

Optical microwave interactions in semiconductor devices

NASA Astrophysics Data System (ADS)

Figueroa, L.; Slayman, C. W.; Yen, H. W.

1980-11-01

The results of an extensive characterization of high speed analog modulation of (GaAl)As injection lasers, high speed optical detectors, and mode locking of (GaAl)As injection lasers are presented. Commercial injection lasers were successfully modulated up to 5 GHz. The 5 GHz value represents a practical upper limit to the modulation bandwith of existing commercial lasers. The laser equivalent circuit was characterized and the parasitics were found to play a significant role in the high speed modulation of the injection laser.

The role of the helicopter in transportation. [technology assessment for use in civil aviation

NASA Technical Reports Server (NTRS)

Dajani, J. S.; Warner, D.; Epstein, D.; Obrien, J.

1976-01-01

A general overview is presented of the role that the helicopter plays in the current aviation scene with special emphasis on its use in the airport access function. Technological problems of present-day aircraft are discussed along with some plausible solutions. The economic and regulatory aspects of commercial helicopter operations are presented. Finally six commercial operations utilizing helicopters are reviewed and conditions that enhance the success of the helicopter in the airport access function are proposed.

Cloud Computing for Complex Performance Codes.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Appel, Gordon John; Hadgu, Teklu; Klein, Brandon Thorin

This report describes the use of cloud computing services for running complex public domain performance assessment problems. The work consisted of two phases: Phase 1 was to demonstrate complex codes, on several differently configured servers, could run and compute trivial small scale problems in a commercial cloud infrastructure. Phase 2 focused on proving non-trivial large scale problems could be computed in the commercial cloud environment. The cloud computing effort was successfully applied using codes of interest to the geohydrology and nuclear waste disposal modeling community.

AdaNET research project

NASA Technical Reports Server (NTRS)

Digman, R. Michael

1988-01-01

The components necessary for the success of the commercialization of an Ada Technology Transition Network are reported in detail. The organizational plan presents the planned structure for services development and technical transition of AdaNET services to potential user communities. The Business Plan is the operational plan for the AdaNET service as a commercial venture. The Technical Plan is the plan from which the AdaNET can be designed including detailed requirements analysis. Also contained is an analysis of user fees and charges, and a proposed user fee schedule.

Physicochemical interactions in solid dosage forms.

PubMed

Narang, Ajit S; Desai, Divyakant; Badawy, Sherif

2012-10-01

Complete characterization and mechanistic understanding of physicochemical interactions in solid dosage forms are not only important for consistent manufacturability, stability, and bioavailability of the drug product, but are also expected under the quality-by-design paradigm of drug development. Lack of this understanding can impact successful and timely development, scale-up, and commercial manufacture of dosage forms. This article highlights the stability and bioavailability implications of physicochemical interactions in dosage forms citing a couple of examples where such interactions necessitated the recall of commercial drug products.

Ocean Observation Instrument

NASA Technical Reports Server (NTRS)

1993-01-01

The Airborne Ocean Color Imager (AOCI) was developed by Daedalus Enterprises, Inc. for Ames Research Center under a Small Business Innovation Research (SBIR) contract as a simulator for an advanced oceanographic satellite instrument. The instrument measures water temperature and detects water color in nine wavelengths. Water color indicates chlorophyll content or phytoplankton. After EOCAP assistance and technical improvements, the AOCI was successfully commercialized by Daedalus Enterprises, Inc. One version provides commercial fishing fleets with information about fish locations, and the other is used for oceanographic research.

Prepping Orbital Sciences? Cygnus commercial cargo spacecraft for undock

NASA Image and Video Library

2013-10-21

ISS037-E-016758 (21 Oct. 2013) --- European Space Agency astronaut Luca Parmitano, Expedition 37 flight engineer, gives a thumbs up signal after closing the hatch between the International Space Station’s Harmony node and the Orbital Sciences’ Cygnus commercial cargo spacecraft in preparation for its release after completing a successful demonstration mission to the space station. Cygnus delivered 1,300 pounds of gear on Sept. 29 when it arrived and was captured by Canadarm2 and berthed to the Harmony node.

Gravity-Dependent Transport in Industrial Processes

NASA Technical Reports Server (NTRS)

Ostrach, Simon; Kamotani, Yasuhiro

1996-01-01

Gravity dependent transport phenomena in various industrial processes are investigated in order to indicate new directions for micro-gravity research that enhance the commercial success of the space program. The present article describes the commercialization possibilities of such topics associated with physicochemical transport phenomena. The topics are: coating flow, rotating electrochemical system, and convection in low Plandtl number fluids. The present study is directed to understand these phenomena, and to develop a knowledge base for their applications with emphasis to a micro-gravity environment.

Preparation, characterization, physical testing and performance of fluorocarbon membranes and separators

NASA Technical Reports Server (NTRS)

Lagow, R. J.; Dumitru, E. T.

1982-01-01

The direct fluorination method of converting carefully selected hydrocarbon substrates to fluorinated membranes was successfully applied to produce promising, novel membranes for electrochemical devices. A family of polymer blends was identified which permits wide latitude in the concentration of both crosslinks and carboxyl groups in hydrocarbon membranes. These membranes were successfully fluorinated and are potentially competitive with commercial membranes in performance, and potentially much cheaper in price.

Scleral patch grafts in the management of uveal and ocular surface tumors.

PubMed

Barman, Manabjyoti; Finger, Paul T; Milman, Tatyana

2012-12-01

To evaluate the outcome of scleral patch grafts in a series of patients undergoing management for uveal and ocular surface tumors. Case series. Ten patients underwent scleral patch grafting. Five patients had uveal melanoma with extrascleral extension, 2 patients had scleromalacia secondary to plaque radiotherapy for uveal melanoma, 2 patients had suspicious uveoscleral nevi, and 1 patient had invasive conjunctival squamous cell carcinoma with scleral necrosis. Retrospective, interventional, noncomparative chart review of patients undergoing treatment for ocular tumors followed by scleral grafts in a tertiary eye care center in the United States between September 2003 and January 2011. Sclera was reconstructed with allogenic scleral grafts. Clinical observations were performed after grafting. Structural integrity, appearance, and stability of the grafts. Ten patients were reviewed. All melanoma cases received plaque radiotherapy with palladium 103. The cases with nevi and squamous cell carcinoma underwent local resection with cryotherapy as primary treatment. In 8 cases, scleral grafting was performed as part of the initial surgery. In all of these cases, satisfactory anatomic and functional outcomes were achieved. In 2 cases with scleromalacia secondary to radiotherapy for uveal melanoma, grafts were placed several years after the initial treatment. In these 2 cases, one showed signs of graft retraction, whereas another showed graft thinning. No patients experienced graft infection, rejection, or tumor recurrence. In this series, scleral grafts were well accepted when placed as part of the primary tumor management despite synchronous radiotherapy, scleral resection, or cryotherapy. Grafting was less successful when performed as a late procedure for radiation-induced scleromalacia. The author(s) have no proprietary or commercial interest in any materials discussed in this article. Copyright © 2012 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.

TS0-C142, Lithium Batteries (proposed)

DOT National Transportation Integrated Search

2000-01-01

Success in developing IVHS collision avoidance systems that are both commercially attractive and effective will depend in large part on how well product designers understand and accommodate human factors considerations in their designs. Help from the...

77 FR 33859 - Carbon Dioxide Fire Suppression Systems on Commercial Vessels

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-07

...-based systems under NFPA 12 and its wide and inexpensive availability. The success and availability of... because of the availability of better alternatives, and that we should ban gas- driven alarms and...

Low ground clearance vehicle detection and warning.

DOT National Transportation Integrated Search

2015-06-01

A Low Ground Clearance Vehicle Detection : System (LGCVDS) determines if a commercial : motor vehicle can successfully clear a highwayrail : grade crossing and notifies the driver when : his or her vehicle cannot safely traverse the : crossing. That ...

Modeling of short fiber reinforced injection moulded composite

NASA Astrophysics Data System (ADS)

Kulkarni, A.; Aswini, N.; Dandekar, C. R.; Makhe, S.

2012-09-01

A micromechanics based finite element model (FEM) is developed to facilitate the design of a new production quality fiber reinforced plastic injection molded part. The composite part under study is composed of a polyetheretherketone (PEEK) matrix reinforced with 30% by volume fraction of short carbon fibers. The constitutive material models are obtained by using micromechanics based homogenization theories. The analysis is carried out by successfully coupling two commercial codes, Moldflow and ANSYS. Moldflow software is used to predict the fiber orientation by considering the flow kinetics and molding parameters. Material models are inputted into the commercial software ANSYS as per the predicted fiber orientation and the structural analysis is carried out. Thus in the present approach a coupling between two commercial codes namely Moldflow and ANSYS has been established to enable the analysis of the short fiber reinforced injection moulded composite parts. The load-deflection curve is obtained based on three constitutive material model namely an isotropy, transversely isotropy and orthotropy. Average values of the predicted quantities are compared to experimental results, obtaining a good correlation. In this manner, the coupled Moldflow-ANSYS model successfully predicts the load deflection curve of a composite injection molded part.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fitzpatrick, Stephen W.

This project involved a three-year program managed by BioMetics, Inc. (Waltham, MA) to demonstrate the commercial feasibility of Biofine thermochemical process technology for conversion of cellulose-containing wastes or renewable materials into levulinic acid, a versatile platform chemical. The program, commencing in October 1995, involved the design, procurement, construction and operation of a plant utilizing the Biofine process to convert 1 dry ton per day of paper sludge waste. The plant was successfully designed, constructed, and commissioned in 1997. It was operated for a period of one year on paper sludge from a variety of source paper mills to collect datamore » to verify the design for a commercial scale plant. Operational results were obtained for four different feedstock varieties. Stable, continuous operation was achieved for two of the feedstocks. Continuous operation of the plant at demonstration scale provided the opportunity for process optimization, development of operational protocols, operator training and identification of suitable materials of construction for scale up to commercial operation . Separated fiber from municipal waster was also successfully processed. The project team consisted of BioMetics Inc., Great Lakes Chemical Corporation (West Lafayette, IN), and New York State Energy Research and Development Authority (Albany, NY).« less

A Y-chromosome STR marker should be added to commercial multiplex STR kits.

PubMed

Oz, Carla; Zaken, Neomi; Amiel, Merav; Zamir, Ashira

2008-07-01

Autosomal short tandem repeat (STR) analysis has become highly relevant in the identification of victims from mass disasters and terrorist attacks. In such events, gender misidentification can be of grave consequences, yet the list reporting amelogenin amplification failure using STR multiplex kits continues to grow. Presented here are three such examples. In the first case, we present two male suspects who demonstrated amelogenin Y-deficient results using two commercial kit procedures. The presence of their Y chromosomes was proven by obtaining a Y-haplotype. The second case demonstrated a profile from a third male suspect where only the Y homolog of the XY pair was amplified. In events such as mass disasters or terrorist attacks, timely and reliable high throughput DNA typing results are essential. As the number of reported cases of amplification failure at the amelogenin gene continues to grow, we suggest that the incorporation of a better gender identification tool in commercial kits is crucial.

Mining Health App Data to Find More and Less Successful Weight Loss Subgroups

PubMed Central

2016-01-01

Background More than half of all smartphone app downloads involve weight, diet, and exercise. If successful, these lifestyle apps may have far-reaching effects for disease prevention and health cost-savings, but few researchers have analyzed data from these apps. Objective The purposes of this study were to analyze data from a commercial health app (Lose It!) in order to identify successful weight loss subgroups via exploratory analyses and to verify the stability of the results. Methods Cross-sectional, de-identified data from Lose It! were analyzed. This dataset (n=12,427,196) was randomly split into 24 subsamples, and this study used 3 subsamples (combined n=972,687). Classification and regression tree methods were used to explore groupings of weight loss with one subsample, with descriptive analyses to examine other group characteristics. Data mining validation methods were conducted with 2 additional subsamples. Results In subsample 1, 14.96% of users lost 5% or more of their starting body weight. Classification and regression tree analysis identified 3 distinct subgroups: “the occasional users” had the lowest proportion (4.87%) of individuals who successfully lost weight; “the basic users” had 37.61% weight loss success; and “the power users” achieved the highest percentage of weight loss success at 72.70%. Behavioral factors delineated the subgroups, though app-related behavioral characteristics further distinguished them. Results were replicated in further analyses with separate subsamples. Conclusions This study demonstrates that distinct subgroups can be identified in “messy” commercial app data and the identified subgroups can be replicated in independent samples. Behavioral factors and use of custom app features characterized the subgroups. Targeting and tailoring information to particular subgroups could enhance weight loss success. Future studies should replicate data mining analyses to increase methodology rigor. PMID:27301853

Online Tutor 2.0: Methodologies and Case Studies for Successful Learning

ERIC Educational Resources Information Center

García-Peñalvo, Francisco José, Ed.; Seoane-Pardo, Antonio Miguel, Ed.

2014-01-01

After centuries of rethinking education and learning, the current theory is based on technology's approach to and affect on the planned interaction between knowledge trainers and trainees. "Online Tutor 2.0: Methodologies and Case Studies for Successful Learning" demonstrates, through the exposure of successful cases in online education…

[Establishment of A1E3 and B1C4 monoclonal antibody-based ELISA for detecting circulating antigen of Schistosoma japonicum and its preliminary application].

PubMed

Cai, Yu-Chun; Chen, Shao-Hong; Tian, Li-Guang; Chu, Yan-Hong; Lu, Yan; Chen, Mu-Xin; Ai, Lin; Zhou, Yang; Chen, Jia-Xu

2014-02-01

To establish A1E3 and B1C4 monoclonal antibody-based ELISA for detecting circulating antigen of Schistosoma japonicum and explore its application value in the field. The characteristics of A1E3 and B1C4 monoclonal antibodies were analyzed by SDS-PAGE and Western blotting. The SEA-based ELISA was used to evaluate the titers of A1E3 and B1C4. The orthogonal test was used to determine the best concentration of coating antibody B1C4 and optimal working concentration of A1E3-HRP. Under the optimal conditions, the serum samples of 20 acute schistosomiasis cases, 46 chronic schistosomiasis cases, and 20 control sera were tested to evaluate its detection sensitivity and specificity. Seventy-two antibody positive serum samples from Jiangling County of Hubei Province were detected and compared to a commercially available ELISA kit, to evaluate the detection effects of this method. The results of SDS-PAGE demonstrated that the purified A1E3 and B1C4 contained a clear heavy chain with molecular weight of 88,000 and 52,000 respectively and had the same light chain with molecular weight of 20,000; while Western blotting demonstrated that A1E3 and B1C4 could be recognized by SEA and serum samples of acute schistosomiasis cases. The SEA-based ELISA demonstrated the titers of B1C4 and A1E3 were 1:10(5) and 1:30,000, respectively. The serum samples from all the acute cases and 86.9% of the chronic cases showed a positive reaction. All of the control sera from healthy persons gave a negative response. The positive rates of the double monoclonal antibody ELISA and commercial ELISA for detecting the circulating antigen were 45.8% and 43.1% respectively, and there was no significant difference between the results of the two methods. A1E3 and B1C4 monoclonal antibody-based ELISA is established successfully. It exhibits a high sensitivity and specificity in detecting circulating antigen of Schistosoma japonicum.

Properties of a monopivot centrifugal blood pump manufactured by 3D printing.

PubMed

Nishida, Masahiro; Negishi, Takumi; Sakota, Daisuke; Kosaka, Ryo; Maruyama, Osamu; Hyakutake, Toru; Kuwana, Katsuyuki; Yamane, Takashi

2016-12-01

An impeller the same geometry as the impeller of a commercial monopivot cardiopulmonary bypass pump was manufactured using 3D printing. The 3D-printed impeller was integrated into the pump casing of the commercially available pump to form a 3D-printed pump model. The surface roughness of the impeller, the hydraulic performance, the axial displacement of the rotating impeller, and the hemolytic properties of the 3D-printed model were measured and compared with those of the commercially available model. Although the surface roughness of the 3D-printed model was significantly larger than that of the commercially available model, the hydraulic performance of the two models almost coincided. The hemolysis level of the 3D-printed model roughly coincided with that of the commercially available model under low-pressure head conditions, but increased greatly under high-pressure head conditions, as a result of the narrow gap between the rotating impeller and the pump casing. The gap became narrow under high-pressure head conditions, because the axial thrust applied to the impeller increased with increasing impeller rotational speed. Moreover, the axial displacement of the rotating impeller was twice that of the commercially available model, confirming that the elastic deformation of the 3D-printed impeller was larger than that of the commercially available impeller. These results suggest that trial models manufactured by 3D printing can reproduce the hydraulic performance of the commercial product. However, both the surface roughness and the deformation of the trial models must be considered to precisely evaluate the hemolytic properties of the model.

Compact Circuit Preprocesses Accelerometer Output

NASA Technical Reports Server (NTRS)

Bozeman, Richard J., Jr.

1993-01-01

Compact electronic circuit transfers dc power to, and preprocesses ac output of, accelerometer and associated preamplifier. Incorporated into accelerometer case during initial fabrication or retrofit onto commercial accelerometer. Made of commercial integrated circuits and other conventional components; made smaller by use of micrologic and surface-mount technology.

28 CFR 802.10 - Fee schedule.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Guidelines. They reflect direct costs for search, review (in the case of commercial requesters), and... term direct costs means those expenditures the agency actually makes in searching for, review (in the... searching for, reviewing, and duplicating the records sought. Commercial use requesters are not entitled to...

28 CFR 802.10 - Fee schedule.

Code of Federal Regulations, 2012 CFR

2012-07-01

... Guidelines. They reflect direct costs for search, review (in the case of commercial requesters), and... term direct costs means those expenditures the agency actually makes in searching for, review (in the... searching for, reviewing, and duplicating the records sought. Commercial use requesters are not entitled to...

28 CFR 802.10 - Fee schedule.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Guidelines. They reflect direct costs for search, review (in the case of commercial requesters), and... term direct costs means those expenditures the agency actually makes in searching for, review (in the... searching for, reviewing, and duplicating the records sought. Commercial use requesters are not entitled to...

28 CFR 802.10 - Fee schedule.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Guidelines. They reflect direct costs for search, review (in the case of commercial requesters), and... term direct costs means those expenditures the agency actually makes in searching for, review (in the... searching for, reviewing, and duplicating the records sought. Commercial use requesters are not entitled to...

28 CFR 802.10 - Fee schedule.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Guidelines. They reflect direct costs for search, review (in the case of commercial requesters), and... term direct costs means those expenditures the agency actually makes in searching for, review (in the... searching for, reviewing, and duplicating the records sought. Commercial use requesters are not entitled to...

NASA Technology Applications Team: Commercial applications of aerospace technology

NASA Technical Reports Server (NTRS)

1994-01-01

The Research Triangle Institute (RTI) Team has maintained its focus on helping NASA establish partnerships with U.S. industry for dual use development and technology commercialization. Our emphasis has been on outcomes, such as licenses, industry partnerships and commercialization of technologies, that are important to NASA in its mission of contributing to the improved competitive position of U.S. industry. The RTI Team has been successful in the development of NASA/industry partnerships and commercialization of NASA technologies. RTI ongoing commitment to quality and customer responsiveness has driven our staff to continuously improve our technology transfer methodologies to meet NASA's requirements. For example, RTI has emphasized the following areas: (1) Methodology For Technology Assessment and Marketing: RTI has developed and implemented effective processes for assessing the commercial potential of NASA technologies. These processes resulted from an RTI study of best practices, hands-on experience, and extensive interaction with the NASA Field Centers to adapt to their specific needs. (2) Effective Marketing Strategies: RTI surveyed industry technology managers to determine effective marketing tools and strategies. The Technology Opportunity Announcement format and content were developed as a result of this industry input. For technologies with a dynamic visual impact, RTI has developed a stand-alone demonstration diskette that was successful in developing industry interest in licensing the technology. And (3) Responsiveness to NASA Requirements: RTI listened to our customer (NASA) and designed our processes to conform with the internal procedures and resources at each NASA Field Center and the direction provided by NASA's Agenda for Change. This report covers the activities of the Research Triangle Institute Technology Applications Team for the period 1 October 1993 through 31 December 1994.

Simultaneous quantification of six alkaloid components from commercial stemonae radix by solid phase extraction-high-performance liquid chromatography coupled with evaporative light scattering detector

PubMed Central

Zhang, Rong-Rong; Lu, Dan-Yi; Yang, Zhen-Ya; Zhao, Wen; But, Paul Pui-Hay; Shaw, Pang-Chui; Jiang, Ren-Wang; Ma, Zhi-Guo

2015-01-01

Background: Stemonae radix has been applied in traditional Chinese medicine for centuries. Alkaloids are the main active ingredient in stemonae radix, so their composition and concentration levels are directly linked to clinic effects. Objective: The objective was to develop an analytical method with multiple markers for quality survey of commercial stemonae radix. Materials and Methods: A method for simultaneous determination of six compounds in commercial stemonae radix was performed using solid-phase extraction and high-performance liquid chromatography coupled with evaporative light scattering detector. The separation was carried out on an Agilent TC-C18 column with 0.1% acetonitrile solution of triethylamine aqueous solution and acetonitrile as the mobile phase under gradient elution within 70 min. The hierarchical clustering analysis (HCA) was successfully used to classify the samples in accordance with their chemical constituents. Results: Linearity (R2 > 0.9990), intra- and inter-day precision (relative standard deviations <4%), limit of detection (0.011–0.086 μg/mL), limit of quantification (0.033–0.259 μg/mL) of the six alkaloids were determined, and the recoveries were between 96.6% and 103.7%. The method was successfully applied to analysis 36 batches of commercial stemonae radix. All the samples could be classified into five clusters by HCA. Conclusion: This article provides an accurate and simple analytical method for quality survey of commercial stemonae radix. Because of the significant chemical variations, careful selection of Stemona sources with obvious antitussive value but devoid of croomine followed by good agricultural practice and good manufacturing practice process is suggested. PMID:25829776

Chemosensitization as a Means to Augment Commercial Antifungal Agents

PubMed Central

Campbell, Bruce C.; Chan, Kathleen L.; Kim, Jong H.

2012-01-01

Antimycotic chemosensitization and its mode of action are of growing interest. Currently, use of antifungal agents in agriculture and medicine has a number of obstacles. Foremost of these is development of resistance or cross-resistance to one or more antifungal agents. The generally high expense and negative impact, or side effects, associated with antifungal agents are two further issues of concern. Collectively, these problems are exacerbated by efforts to control resistant strains, which can evolve into a treadmill of higher dosages for longer periods. This cycle in turn, inflates cost of treatment, dramatically. A further problem is stagnation in development of new and effective antifungal agents, especially for treatment of human mycoses. Efforts to overcome some of these issues have involved using combinations of available antimycotics (e.g., combination therapy for invasive mycoses). However, this approach has had inconsistent success and is often associated with a marked increase in negative side effects. Chemosensitization by natural compounds to increase effectiveness of commercial antimycotics is a somewhat new approach to dealing with the aforementioned problems. The potential for safe natural products to improve antifungal activity has been observed for over three decades. Chemosensitizing agents possess antifungal activity, but at insufficient levels to serve as antimycotics, alone. Their main function is to disrupt fungal stress response, destabilize the structural integrity of cellular and vacuolar membranes or stimulate production of reactive oxygen species, augmenting oxidative stress and apoptosis. Use of safe chemosensitizing agents has potential benefit to both agriculture and medicine. When co-applied with a commercial antifungal agent, an additive or synergistic interaction may occur, augmenting antifungal efficacy. This augmentation, in turn, lowers effective dosages, costs, negative side effects and, in some cases, countermands resistance. PMID:22393330

Passive Leak Detection Using Commercial Hydrogen Colorimetric Indicator

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hartmann, Kevin; Buttner, William; Burgess, Robert

Element One, Inc. (www.elem.com), a small business with in Boulder, CO, has been developing hydrogen detection technology based upon a highly selective colorimetric indicator. In its native state, the indicator pigment is a pale gray color, but becomes black upon exposure to hydrogen. The colorimetric change can be readily observed by the naked eye without the need for supplemental electronics or other hardware. Recently, the colorimetric indicator was integrated into a pliable, self-adhesive tape that can readily wrap around pneumatic fittings to serve as a hydrogen leak detector. A prototype version of the Element One indicator tape was tested withinmore » an NREL hydrogen system and successfully identified the unexpected presence of a small leak; a summary document for this case study is presented in Appendix 1. The tape was subsequently configured into 10-foot rolls as a product prototype that has just recently been commercialized and marketed under the tradename DetecTape(R). Figure 1 shows the commercial version of DetecTape along with an indicator sample in its native state and one that had been exposed to hydrogen. DetecTape is a self-adhesive silicone-based tape impregnated with a proprietary hydrogen-sensitive indicator based on transition metal oxides. A length of the tape can be cut from the roll and stretched by a factor of two or three times around a fitting. Due to the self-adhesive property of the tape, this provides a tight seal around the fitting. The seal is not hermetic, and is not intended to prevent the release of a leaking gas. However, a portion of the hydrogen leaking from a wrapped fitting will pass through the tape and react with the active indicator impregnated within the tape, thereby inducing blackening.« less

Development of a Total Energy, Environment and Asset Management (TE2AM tm) Curriculum

DOE Office of Scientific and Technical Information (OSTI.GOV)

O'Leary, Phillip R.

2012-12-31

The University of Wisconsin Department of Engineering Professional Development (EPD) has completed the sponsored project entitled, Development of a Total Energy, Environment and Asset Management (TE2AM) Curriculum. The project involved the development of a structured professional development program to improve the knowledge, skills, capabilities, and competencies of engineers and operators of commercial buildings. TE2AM advances a radically different approach to commercial building design, operation, maintenance, and end of life disposition. By employing asset management principles to the lifecycle of a commercial building, owners and occupants will realize improved building performance, reduced energy consumption and positive environmental impacts. Through our commercializationmore » plan, we intend to offer TE2AM courses and certificates to the professional community and continuously improve TE2AM course materials. The TE2AM project supports the DOE Strategic Theme 1 Energy Security; and will further advance the DOE Strategic Goal 1.4 Energy Productivity. Through participation in the TE2AM curriculum, engineers and operators of commercial buildings will be eligible for a professional certificate; denoting the completion of a prescribed series of learning activities. The project involved a comprehensive, rigorous approach to curriculum development, and accomplished the following goals: 1. Identify, analyze and prioritize key learning needs of engineers, architects and technical professionals as operators of commercial buildings. 2. Design and develop TE2AM curricula and instructional strategies to meet learning needs of the target learning community. 3. Establish partnerships with the sponsor and key stakeholders to enhance the development and delivery of learning programs. 4. Successfully commercialize and sustain the training and certificate programs for a substantial time following the term of the award. The project team was successful in achieving the goals and deliverables set forth in the original proposal. Though attempts were made to adhere to the original project timeline, the team requested, and was granted a 6 month project extension, during which time the project was completed.« less

Geographic Variability in Geocoding Success for West Nile Virus Cases in South Dakota

PubMed Central

Wey, Christine L.; Griesse, Jennifer; Kightlinger, Lon; Wimberly, Michael C.

2009-01-01

Background Geocoding, the process of assigning each case a set of coordinates that closely approximates its true location, is an important component of spatial epidemiological studies. The failure to accurately geocode cases adversely affects the validity and strength of conclusions drawn from the analysis. We investigated whether there were differences among geographic locations and demographic classes in the ability to successfully geocode West Nile virus (WNV) cases in South Dakota. We successfully geocoded 1,354 cases (80.8%) to their street address locations and assigned all 1,676 cases to ZIP code tabulation areas (ZCTAs). Using spatial scan statistics, significant clusters of non-geocoded cases were identified in central and western South Dakota. Geocoding success rates were lower in areas of low population density and on Indian reservations than in other portions of the state. Geocoding success rates were lower for Native Americans than for other races. Spatial epidemiological studies should consider the potential biases that may result from excluding non-geocoded cases, particularly in rural portions of the Great Plains that contain large Native American populations. PMID:19577505

The ethics of commercial surrogate mothering: a response to Casey Humbyrd.

PubMed

Omonzejele, Peter F

2011-01-01

This article critically examines the argument advanced by Casey Humbyrd in support of international commercial surrogate mothering. It finds her arguments unconvincing especially at the point of implementation. This is because the author was unable to demonstrate how regulation and her notion offair compensation would not lead to undue inducement and exploitation in resource-poor settings where urgent needs often exist. In fact, the argument advanced in this article is that commercial surrogate mothering cannot but be exploitative in so far as urgent and compelling needs exist. To logically drive home this point, the elements of exploitation were discussed in order to show that regulation and fair compensation cannot prevent exploitative transaction in commercial surrogate mothering arrangements. This may happen in the same way as regulation and compensation framework have not been successful in preventing the allegations of exploitation in the research context especially where studies are conducted in resource-poor countries.

How Far Gender Role Is Successful in School Management? Cross Case Analysis from Pakistan

ERIC Educational Resources Information Center

Safdar, Qamar

2007-01-01

This article reports a case study research about the management of successful schools with special emphasis on female leadership, to prove that gender does matter in successful school management. A cross case analysis was conducted with three different school leaderships, especially with regard to their profiles, personal, academic and…

Cases on Global E-Learning Practices: Successes and Pitfalls

ERIC Educational Resources Information Center

Sharma, Ramesh C., Ed.; Mishra, Sanjaya, Ed.

2007-01-01

"Cases on Global E-Learning Practices: Successes and Pitfalls" looks into global practices of e-learning, examining the successes and failures of e-learning professionals. It provides a judicious mix of practical experiences and research in the form of case studies. Written by experts from all over the globe, this book shows how to…

Lunar COTS: An Economical and Sustainable Approach to Reaching Mars

NASA Technical Reports Server (NTRS)

Zuniga, Allison F.; Rasky, Daniel; Pittman, Robert B.; Zapata, Edgar; Lepsch, Roger

2015-01-01

The NASA COTS (Commercial Orbital Transportation Services) Program was a very successful program that developed and demonstrated cost-effective development and acquisition of commercial cargo transportation services to the International Space Station (ISS). The COTS acquisition strategy utilized a newer model than normally accepted in traditional procurement practices. This new model used Space Act Agreements where NASA entered into partnerships with industry to jointly share cost, development and operational risks to demonstrate new capabilities for mutual benefit. This model proved to be very beneficial to both NASA and its industry partners as NASA saved significantly in development and operational costs while industry partners successfully expanded their market share of the global launch transportation business. The authors, who contributed to the development of the COTS model, would like to extend this model to a lunar commercial services program that will push development of technologies and capabilities that will serve a Mars architecture and lead to an economical and sustainable pathway to transporting humans to Mars. Over the past few decades, several architectures for the Moon and Mars have been proposed and studied but ultimately halted or not even started due to the projected costs significantly exceeding NASA's budgets. Therefore a new strategy is needed that will fit within NASA's projected budgets and takes advantage of the US commercial industry along with its creative and entrepreneurial attributes. The authors propose a new COTS-like program to enter into partnerships with industry to demonstrate cost-effective, cis-lunar commercial services, such as lunar transportation, lunar ISRU operations, and cis-lunar propellant depots that can enable an economical and sustainable Mars architecture. Similar to the original COTS program, the goals of the proposed program, being notionally referred to as Lunar Commercial Orbital Transfer Services (LCOTS) program will be to: 1) reduce development and operational costs by sharing costs with industry; 2) create new markets in cis-lunar space to further reduce operational costs; and 3) enable NASA to develop an affordable and economical exploration Mars architecture. The paper will describe a plan for a proposed LCOTS program, its potential impact to an eventual Mars architecture and its many benefits to NASA, commercial space industry and the US economy.

36 CFR 1120.51 - Charges for services, generally.

Code of Federal Regulations, 2014 CFR

2014-07-01

... below, for searching for, reviewing (in the case of commercial use requesters only), and duplicating... the fee schedule set forth below, which recover the full direct costs of searching for, reviewing for... from a non-commercial scientific institution) research. (ii) Requesters eligible for free search must...